Utility of Social Modeling for Proliferation Assessment - Preliminary Assessment
Coles, Garill A.; Gastelum, Zoe N.; Brothers, Alan J.; Thompson, Sandra E.
2009-06-01
This Preliminary Assessment draft report will present the results of a literature search and preliminary assessment of the body of research, analysis methods, models and data deemed to be relevant to the Utility of Social Modeling for Proliferation Assessment research. This report will provide: 1) a description of the problem space and the kinds of information pertinent to the problem space, 2) a discussion of key relevant or representative literature, 3) a discussion of models and modeling approaches judged to be potentially useful to the research, and 4) the next steps of this research that will be pursued based on this preliminary assessment. This draft report represents a technical deliverable for the NA-22 Simulations, Algorithms, and Modeling (SAM) program. Specifically this draft report is the Task 1 deliverable for project PL09-UtilSocial-PD06, Utility of Social Modeling for Proliferation Assessment. This project investigates non-traditional use of social and cultural information to improve nuclear proliferation assessment, including nonproliferation assessment, proliferation resistance assessments, safeguards assessments and other related studies. These assessments often use and create technical information about the State’s posture towards proliferation, the vulnerability of a nuclear energy system to an undesired event, and the effectiveness of safeguards. This project will find and fuse social and technical information by explicitly considering the role of cultural, social and behavioral factors relevant to proliferation. The aim of this research is to describe and demonstrate if and how social science modeling has utility in proliferation assessment.
J. W. Li; G. P. Wang; J. Y. Fan; C. F. Chang; C. S. Xu
2011-12-01
Although it is known that hormones, growth factors and integrin promote hepatocyte proliferation in liver regeneration (LR) through ERK1/2 signalling pathway, reports about regulating processes of its intracellular paths in hepatocytes of LR are limited. This study aims at exploring which paths of ERK1/2 signalling pathway participate in the regulation of rat LR, especially in hepatocyte proliferation, and how they do so. In all, 14 paths and 165 genes are known to be involved in ERK1/2 signalling pathway. Of them, 161 genes are included in Rat Genome 230 2.0 Array. This array was used to detect expression changes of genes related to ERK1/2 signalling pathway in isolated hepatocytes of rat LR, showing that 60 genes were related to hepatocytes of LR. In addition, bioinformatics and systems biology methods were used to analyse the roles of 14 above paths in regenerating hepatocytes. We found that three paths, RTK → SHC → GRB2/SOS → RAS → RAF, Integrin → FAK → RAC → PAK → RAF and G → PI3K → RAC → PAK → RAF, promoted the G1 phase progression of hepatocytes by activating ERK1/2. A further four paths, Gq → PLC → PKC → SRC/PYK2 → GRB2/SOS → RAS → RAF, RTK → PLC → PKC → SRC/PYK2 → GRB2/SOS → RAS → RAF, Integrin → FAK/SRC → GRB2/SOS → RAS → RAF and Integrin → FAK → RAC → PAK → RAF, advanced the cell progression of S phase and G2/M checkpoint by activating ERK1/2, and so did PP1/2 → Mek1/2 by decreasing the negative influence on ERK1/2. At the late phase of LR, Gs → AC → EPAC → Rap1 → Raf blocked hepatocyte proliferation by decreasing the activity of ERK1/2 and so did PP1/2 → Mek1/2. In summary, 60 genes and 8 paths of ERK1/2 signalling pathway regulated hepatocyte proliferation in rat LR.
Strengthening the foundations of proliferation assessment tools.
Rexroth, Paul E.; Saltiel, David H.; Rochau, Gary Eugene; Cleary, Virginia D.; Ng, Selena (AREVA NC, Paris, France); Greneche, Dominique (AREVA NC, Paris, France); Giannangeli, Don (Texas A& M University, College Station, TX); Charlton, William S. (Texas A& M University, College Station, TX); Ford, David (Texas A& M University, College Station, TX)
2007-09-01
Robust and reliable quantitative proliferation assessment tools have the potential to contribute significantly to a strengthened nonproliferation regime and to the future deployment of nuclear fuel cycle technologies. Efforts to quantify proliferation resistance have thus far met with limited success due to the inherent subjectivity of the problem and interdependencies between attributes that lead to proliferation resistance. We suggest that these limitations flow substantially from weaknesses in the foundations of existing methodologies--the initial data inputs. In most existing methodologies, little consideration has been given to the utilization of varying types of inputs--particularly the mixing of subjective and objective data--or to identifying, understanding, and untangling relationships and dependencies between inputs. To address these concerns, a model set of inputs is suggested that could potentially be employed in multiple approaches. We present an input classification scheme and the initial results of testing for relationships between these inputs. We will discuss how classifying and testing the relationship between these inputs can help strengthen tools to assess the proliferation risk of nuclear fuel cycle processes, systems, and facilities.
Dynamic proliferation assessment in flow cytometry.
Diermeier-Daucher, Simone; Brockhoff, Gero
2010-09-01
Dynamic proliferation assessment via flow cytometry is legitimately supposed to be the most powerful tool for recording cell cycle kinetics in-vitro. The preeminent feature is a single cell-based multi-informative analysis by temporal high-resolution. Flow cytometric approaches are based on labeling of proliferating cells via thymidine substitution by a base analog (e.g., 5-bromo-2'-deoxyuridine, BrdU) that is added to cell cultures either for a short period of time (pulse labeling) or continuously until cell harvesting. This unit describes the alternative use of the thymidine analog 5-ethynyl-2'-deoxyuridine (EdU) in place of BrdU for three different applications: (1) dynamic proliferation assessment by EdU pulse cell labeling; (2) the same approach as (1) but in combination with live/dead cell discrimination; and (3) dynamic cell cycle analysis based on continuous cell labeling with EdU and Hoechst fluorochrome quenching. In contrast to the detection of BrdU incorporation, EdU-positive cells can be identified by taking advantage of click chemistry, which facilitates a simplified and fast cell preparation. Further analysis options but also limitations of the utilization of EdU are discussed.
Critical crack path assessments in failure investigations
Robert D. Caligiuri
2015-10-01
Full Text Available This paper presents a case study in which identification of the controlling crack path was critical to identifying the root cause of the failure. The case involves the rupture of a 30-inch (0.76 m natural gas pipeline in 2010 that tragically led to the destruction of a number of homes and the loss of life. The segment of the pipeline that ruptured was installed in 1956. The longitudinal seam of the segment that ruptured was supposed to have been fabricated by double submerged arc welding. Unfortunately, portions of the segment only received a single submerged arc weld on the outside, leaving unwelded areas on the inside diameter. Post-failure examination of the segment revealed that the rupture originated at one of these unwelded areas. Examination also revealed three additional crack paths or zones emanating from the unwelded area: a zone of ductile tearing, a zone of fatigue, and a zone of cleavage fracture, in that sequence. Initial investigators ignored the ductile tear, assumed the critical crack path was the fatigue component, and (incorrectly concluded that the root cause of the incident was the failure of the operator to hydrotest the segment after it was installed in 1956. However, as discussed in this paper, the critical path or mechanism was the ductile tear. Furthermore, it was determined that the ductile tear was created during the hydrotest at installation by a mechanism known as pressure reversal. Thus the correct root cause of the rupture was the hydrotest the operator subjected the segment to at installation, helping to increase the awareness of operators and regulators about the potential problems associated with hydrotesting.
Assessing the Learning Path Specification: a Pragmatic Quality Approach
Janssen, José; Berlanga, Adriana; Heyenrath, Stef; Martens, Harrie; Vogten, Hubert; Finders, Anton; Herder, Eelco; Hermans, Henry; Melero, Javier; Schaeps, Leon; Koper, Rob
2010-01-01
Janssen, J., Berlanga, A. J., Heyenrath, S., Martens, H., Vogten, H., Finders, A., Herder, E., Hermans, H., Melero Gallardo, J., Schaeps, L., & Koper, R. (2010). Assessing the Learning Path Specification: a Pragmatic Quality Approach. Journal of Universal Computer Science, 16(21), 3191-3209.
A Twenty Year Path: Learning about Assessment; Learning from Assessment
Debra L. Gilchrist
2010-03-01
Full Text Available This article reviews the development of educational assessment from the 1970’s to the present, including discussions of basic working definitions and models of assessment in information literacy. It reflects on what librarians have learned from assessment and about assessment, and how this information is being used to improve current and future assessment offerings.
Proliferation resistance assessment of high temperature gas reactors
Chikamatsu N, M. A. [Instituto Tecnologico y de Estudios Superiores de Monterrey, Campus Santa Fe, Av. Carlos Lazo No. 100, Santa Fe, 01389 Mexico D. F. (Mexico); Puente E, F., E-mail: midori.chika@gmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)
2014-10-15
The Generation IV International Forum has established different objectives for the new generation of reactors to accomplish. These objectives are focused on sustain ability, safety, economics and proliferation resistance. This paper is focused on how the proliferation resistance of the High Temperature Gas Reactors (HTGR) is assessed and the advantages that these reactors present currently. In this paper, the focus will be on explaining why such reactors, HTGR, can achieve the goals established by the GIF and can present a viable option in terms of proliferation resistance, which is an issue of great importance in the field of nuclear energy generation. The reason why the HTGR are being targeted in this writing is that these reactors are versatile, and present different options from modular reactors to reactors with the same size as the ones that are being operated today. Besides their versatility, the HTGR has designed features that might improve on the overall sustain ability of the nuclear reactors. This is because the type of safety features and materials that are used open up options for industrial processes to be carried out; cogeneration for instance. There is a small section that mentions how HTGR s are being developed in the international sector in order to present the current world view in this type of technology and the further developments that are being sought. For the proliferation resistance section, the focus is on both the intrinsic and the extrinsic features of the nuclear systems. The paper presents a comparison between the features of Light Water Reactors (LWR) and the HTGR in order to be able to properly compare the most used technology today and one that is gaining international interest. (Author)
Overview of DOE-NE Proliferation and Terrorism Risk Assessment
Sadasivan, Pratap [Los Alamos National Laboratory
2012-08-24
Research objectives are: (1) Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of current reactors; (2) Develop improvements in the affordability of new reactors to enable nuclear energy; (3) Develop Sustainable Nuclear Fuel Cycles; and (4) Understand and minimize the risks of nuclear proliferation and terrorism. The goal is to enable the use of risk information to inform NE R&D program planning. The PTRA program supports DOE-NE's goal of using risk information to inform R&D program planning. The FY12 PTRA program is focused on terrorism risk. The program includes a mix of innovative methods that support the general practice of risk assessments, and selected applications.
An Assessment of Energy-Related Career Paths of Senior Industrial Assessment Center Program Alumni
Martin, M.A.
2003-10-20
The purpose of this study was to assess the career paths of alumni from the U.S. Department of Energy's Industrial Assessment Center (IAC) program. IAC was originally named the Energy Analysis and Diagnostic Center (EADC) program when it began in association with four schools in 1976. The current IAC program provides funding to 26 engineering colleges, located in centers across the United States, to conduct energy, waste, and productivity assessments for small- to medium-sized manufacturing establishments within their respective regions. Through part-time employment with the university, students receive training and in turn conduct assessments for local manufacturers, under the direct supervision of engineering faculty. Annually, IAC participants conduct over 700 assessments, and each assessment generates recommendations for energy savings, energy cost savings, and waste and productivity cost savings customized for individual clients. An earlier study determined that energy savings could be attributed to alumni of the IAC program who take their IAC experiences with them to the professional workplace. During their careers, the alumni conduct additional energy assessments as well as influence energy efficiency through design, teaching and training, and other activities. Indeed, a significant level of program benefits can be attributed to the alumni. This project addressed such specific questions as: How many years after graduation are IAC alumni involved in energy-efficiency activities? What different methods do they use to influence energy-efficiency decisions? To answer these questions, the University of Tennessee, Knoxville (UT) surveyed IAC senior alumni, defined as those who graduated in 1995 or earlier. Section 2 describes the survey used in this research. The actual survey can be found in Appendix A. Section 3 describes our approach to data collection. Section 4 presents descriptive statistics about the senior alumni who responded to the survey. Section 5
Coles, Garill A.; Brothers, Alan J.; Gastelum, Zoe N.; Olson, Jarrod; Thompson, Sandra E.
2009-10-26
The Utility of Social Modeling for Proliferation Assessment project (PL09-UtilSocial) investigates the use of social and cultural information to improve nuclear proliferation assessments, including nonproliferation assessments, Proliferation Resistance (PR) assessments, safeguards assessments, and other related studies. These assessments often use and create technical information about a host State and its posture towards proliferation, the vulnerability of a nuclear energy system (NES) to an undesired event, and the effectiveness of safeguards. This objective of this project is to find and integrate social and technical information by explicitly considering the role of cultural, social, and behavioral factors relevant to proliferation; and to describe and demonstrate if and how social science modeling has utility in proliferation assessment. This report describes a modeling approach and how it might be used to support a location-specific assessment of the PR assessment of a particular NES. The report demonstrates the use of social modeling to enhance an existing assessment process that relies on primarily technical factors. This effort builds on a literature review and preliminary assessment performed as the first stage of the project and compiled in PNNL-18438. [ T his report describes an effort to answer questions about whether it is possible to incorporate social modeling into a PR assessment in such a way that we can determine the effects of social factors on a primarily technical assessment. This report provides: 1. background information about relevant social factors literature; 2. background information about a particular PR assessment approach relevant to this particular demonstration; 3. a discussion of social modeling undertaken to find and characterize social factors that are relevant to the PR assessment of a nuclear facility in a specific location; 4. description of an enhancement concept that integrates social factors into an existing, technically
Chang, H. L.; Ko, W. I.; Park, S. H.; Kim, H. D.; Park, G. I. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)
2015-10-15
To illustrate the proposed Prosta process, to demonstrate its usefulness, and to provide input to a revision of the INPRO manual in the area of proliferation resistance, a case study has been carried out with a conceptually designed sodium cooled fast reactor (SFR) metal fuel manufacturing facility (SFMF), representing novel technology still in the conceptual design phase. A coarse acquisition path analysis has been carried out of the SFMF to demonstrate the assessment process with identified different target materials. The case study demonstrates the usefulness of the proposed PROSA PR assessment process and the interrelationship of the PR assessment with the safeguards-by-design process, identifying potential R and D needs. The PROSA process has been applied to a conceptually designed SFMF, representing novel technology that is still in the conceptual design phase at KAERI. The case study demonstrated that the proposed PROSA process is simpler and easier to perform than the original INPRO methodology and can be applied from the early stage of design showing the relationship of PR assessment to the safeguard-by-design process. New evaluation questionnaire for UR1 is more logical and comprehensive, and provides the legal basis enabling the IAEA to achieve its safeguards objectives including the detection of undeclared nuclear materials and activities. NES information catalogue replacing UR2 was a useful modification and supports safeguardability assessment at the NES and facility level. The proposed PROSA process is also capable to identify strengths and weaknesses of a system in the area of proliferation resistance in a generally understandable form, including R and D gaps that need to be filled in order to meet the criteria for proliferation resistance of a nuclear energy system.
Noninvasive Assessment of Tumor Cell Proliferation in Animal Models
Matthias Edinger
1999-10-01
Full Text Available Revealing the mechanisms of neoplastic disease and enhancing our ability to intervene in these processes requires an increased understanding of cellular and molecular changes as they occur in intact living animal models. We have begun to address these needs by developing a method of labeling tumor cells through constitutive expression of an optical reporter gene, noninvasively monitoring cellular proliferation in vivo using a sensitive photon detection system. A stable line of HeLa cells that expressed a modified firefly luciferase gene was generated, proliferation of these cells in irradiated severe combined immunodeficiency (SCID mice was monitored. Tumor cells were introduced into animals via subcutaneous, intraperitoneal and intravenous inoculation and whole body images, that revealed tumor location and growth kinetics, were obtained. The number of photons that were emitted from the labeled tumor cells and transmitted through murine tissues was sufficient to detect 1×103 cells in the peritoneal cavity, 1×104 cells at subcutaneous sites and 1×106 circulating cells immediately following injection. The kinetics of cell proliferation, as measured by photon emission, was exponential in the peritoneal cavity and at subcutaneous sites. Intravenous inoculation resulted in detectable colonies of tumor cells in animals receiving more than 1×103 cells. Our demonstrated ability to detect small numbers of tumor cells in living animals noninvasively suggests that therapies designed to treat minimal disease states, as occur early in the disease course and after elimination of the tumor mass, may be monitored using this approach. Moreover, it may be possible to monitor micrometastases and evaluate the molecular steps in the metastatic process. Spatiotemporal analyses of neoplasia will improve the predictability of animal models of human disease as study groups can be followed over time, this method will accelerate development of novel therapeutic
2012-05-18
...: Population Assessment of Tobacco and Health (PATH) Study. Type of Information Collection Request: NEW. Need... mandate under the Family Smoking Prevention and Tobacco Control Act (FSPTCA) to regulate tobacco-product advertising, labeling, marketing, constituents, ingredients, and additives. These regulatory changes...
Molenaar, W M; Plaat, B E; Berends, E R; te Meerman, G J
2000-01-01
In hematoxylin-eosin-stained sections of 20 pediatric sarcomas the mitotic index was assessed by four experienced pathologists and four less-experienced observers without prior instructions. In adjacent sections immunolabeled for MIB-1, the proliferation index was assessed as the estimated percentag
1980-06-01
The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities.
Matisziw, Timothy C
2010-01-01
The maintenance of system flow is critical for effective network operation. Any type of disruption to network facilities (arcs/nodes) potentially risks loss of service, leaving users without access to important resources. It is therefore an important goal of planners to assess infrastructures for vulnerabilities, identifying those vital nodes/arcs whose debilitation would compromise the most source-sink (s-t) interaction or system flow. Due to the budgetary limitations of disaster management agencies, protection/fortification and planning for the recovery of these vital infrastructure facilities is a logical and efficient proactive approach to reducing worst-case risk of service disruption. Given damage to a network, evaluating the potential for flow between s-t pairs requires assessing the availability of an operational s-t path. Recent models proposed for identifying infrastructure vital to system flow have relied on enumeration of all s-t paths to support this task. This paper proposes an alternative model...
Complete Coverage Path Planning for a Multi-UAV Response System in Post-Earthquake Assessment
Arman Nedjati; Gokhan Izbirak; Bela Vizvari; Jamal Arkat
2016-01-01
This paper presents a post-earthquake response system for a rapid damage assessment. In this system, multiple Unmanned Aerial Vehicles (UAVs) are deployed to collect the images from the earthquake site and create a response map for extracting useful information. It is an extension of well-known coverage path problem (CPP) that is based on the grid pattern map decomposition. In addition to some linear strengthening techniques, two mathematic formulations, 4-index and 5-index models, are propos...
Utility of Social Modeling in Assessment of a State’s Propensity for Nuclear Proliferation
Coles, Garill A.; Brothers, Alan J.; Whitney, Paul D.; Dalton, Angela C.; Olson, Jarrod; White, Amanda M.; Cooley, Scott K.; Youchak, Paul M.; Stafford, Samuel V.
2011-06-01
This report is the third and final report out of a set of three reports documenting research for the U.S. Department of Energy (DOE) National Security Administration (NASA) Office of Nonproliferation Research and Development NA-22 Simulations, Algorithms, and Modeling program that investigates how social modeling can be used to improve proliferation assessment for informing nuclear security, policy, safeguards, design of nuclear systems and research decisions. Social modeling has not to have been used to any significant extent in a proliferation studies. This report focuses on the utility of social modeling as applied to the assessment of a State's propensity to develop a nuclear weapons program.
Novel T lymphocyte proliferation assessment using whole mouse cryo-imaging
Wuttisarnwattana, Patiwet; Raza, Syed A.; Eid, Saada; Cooke, Kenneth R.; Wilson, David L.
2014-03-01
New imaging technologies enable one to assess T-cell proliferation, an important feature of the immunological response. However, none of the traditional imaging modalities allow one to examine quantiatively T-cell function with microscopic resolution and single cell sensitivity over an entire mouse. To address this need, we established T-cells proliferation assays using 3D microscopic cryo-imaging. Assays include: (1) biodistribution of T-cells, (2) secondary lymphoid organ (SLO) volume measurement, (3) carboxyfluorescein succinimidyl ester (CFSE) dilution per cell as cells divide. To demonstrate the application, a graft-versus-host-disease (GVHD) model was used. 3D visualization show that T-cells specifically homed to the SLOs (spleen and lymph nodes) as well as GVHD target organs (such as GI-tract, liver, skin and thymus).The spleen was chosen as representative of the SLOs. For spleen size analysis, volumes of red and white pulp were measured. Spleen volumes of the allogeneic mice (with GVHD) were significantly larger than those of the syngeneic mice (without GVHD) at 72 to 120 hours post-transplant. For CFSE dilution approach, we employed color-coded volume rendering and probability density function (PDF) of single cell intensity to assess T-cell proliferation in the spleen. As compared to syngeneic T-cells, the allogeneic T-cells quickly aggregated in the spleen as indicated by increasing of CFSE signal over the first 48 hours. Then they rapidly proliferated as evidenced by reduced CFSE intensity (at 48-96 hours). Results suggest that assays can be used to study GVHD treatments using T-cell proliferation and biodistibution as assays. In summary, this is the first time that we are able to track and visualize T-cells in whole mouse with single cell sensitivity. We believe that our technique can be an alternative choice to traditional in vitro immunological proliferation assays by providing assessment of proliferation in an in vivo model.
Wood, Charles E; Hukkanen, Renee R; Sura, Radhakrishna; Jacobson-Kram, David; Nolte, Thomas; Odin, Marielle; Cohen, Samuel M
2015-08-01
Increased cell proliferation is a central key event in the mode of action for many non-genotoxic carcinogens, and quantitative cell proliferation data play an important role in the cancer risk assessment of many pharmaceutical and environmental compounds. Currently, there is limited unified information on assay standards, reference values, targeted applications, study design issues, and quality control considerations for proliferation data. Here, we review issues in measuring cell proliferation indices, considerations for targeted studies, and applications within current risk assessment frameworks. As the regulatory environment moves toward more prospective evaluations based on quantitative pathway-based models, standardization of proliferation assays will become an increasingly important part of cancer risk assessment. To help address this development, we also discuss the potential role for proliferation data as a component of alternative carcinogenicity testing models. This information should improve consistency of cell proliferation methods and increase efficiency of targeted testing strategies.
Sorority Affiliation and Sexual Assault Victimization: Assessing Vulnerability Using Path Analysis.
Franklin, Cortney A
2016-07-01
The current research used survey data from 282 college women to investigate the relationship between female Greek membership and sexual assault victimization. Drawing from routine activity theory, low self-control, and social learning theory, this study tested a theoretical model that identified pertinent factors present among sorority environments to determine the relationships between Greek affiliation and sexual assault. Path analyses revealed that sorority women reported consuming more alcohol and with greater frequency, increased risk-taking behavior, delayed assessments of threat and responses to risk, and increased contact with fraternity men-all of which significantly predicted sexual assault. Future theory, research, and policy directions are proposed.
Bari,R.
2008-03-01
This report describes a framework for proliferation resistance and physical protection evaluation for the fuel cycle systems envisioned in the expansion of nuclear power for electricity generation. The methodology is based on an approach developed as part of the Generation IV technical evaluation framework and on a qualitative evaluation approach to policy factors similar to those that were introduced in previous Nonproliferation Impact Assessments performed by DOE.
Cardiac cell proliferation assessed by EdU, a novel analysis of cardiac regeneration.
Zeng, Bin; Tong, Suiyang; Ren, Xiaofeng; Xia, Hao
2016-08-01
Emerging evidence suggests that mammalian hearts maintain the capacity for cardiac regeneration. Rapid and sensitive identification of cardiac cellular proliferation is prerequisite for understanding the underlying mechanisms and strategies of cardiac regeneration. The following immunologically related markers of cardiac cells were analyzed: cardiac transcription factors Nkx2.5 and Gata 4; specific marker of cardiomyocytes TnT; endothelial cell marker CD31; vascular smooth muscle marker smooth muscle myosin IgG; cardiac resident stem cells markers IsL1, Tbx18, and Wt1. Markers were co-localized in cardiac tissues of embryonic, neonatal, adult, and pathological samples by 5-ethynyl-2'-deoxyuridine (EdU) staining. EdU was also used to label isolated neonatal cardiomyocytes in vitro. EdU robustly labeled proliferating cells in vitro and in vivo, co-immunostaining with different cardiac cells markers. EdU can rapidly and sensitively label proliferating cardiac cells in developmental and pathological states. Cardiac cell proliferation assessed by EdU is a novel analytical tool for investigating the mechanism and strategies of cardiac regeneration in response to injury.
Avedon, Roger Edmond
This dissertation addresses the value of developing diversion- and theft-resistant nuclear power technology, given uncertain future demand for nuclear power, and uncertain risks of nuclear terrorism and of proliferation from the reprocessing of civilian plutonium. The methodology comprises four elements: Economics. An economic growth model coupled with market penetration effects for plutonium and for the hypothetical new technology provides a range of estimates for future nuclear demand. A flow model accounts for the longevity of capital assets (nuclear plants) over time. Terrorism. The commercial nuclear fuel cycle may provide a source of fissile material for terrorists seeking to construct a crude nuclear device. An option value model is used to estimate the effects of the hypothetical new technology on reducing the probability of theft. A game theoretic model is used to explore the deterrence value of physical security and then to draw conclusions about how learning on the part of terrorists or security forces might affect the theft estimate. The principal uncertainties in the theft model can be updated using Bayesian techniques as new data emerge. Proliferation. Access to fissile material is the principal technical impediment to a state's acquisition of nuclear weapons. A game theoretic model is used to determine the circumstances under which a state may proliferate via diversion. The model shows that the hypothetical new technology will have little value for counter-proliferation if diversion is not a preferred proliferation method. A technology policy analysis of the choice of proliferation method establishes that diversion is unlikely to be used because it has no constituency among the important parties to the decision, namely the political leadership, the scientific establishment, and the military. Value. The decision whether to develop a diversion- and theft-resistant fuel cycle depends on the perceived value of avoiding nuclear terrorism and proliferation
Complete Coverage Path Planning for a Multi-UAV Response System in Post-Earthquake Assessment
Arman Nedjati
2016-12-01
Full Text Available This paper presents a post-earthquake response system for a rapid damage assessment. In this system, multiple Unmanned Aerial Vehicles (UAVs are deployed to collect the images from the earthquake site and create a response map for extracting useful information. It is an extension of well-known coverage path problem (CPP that is based on the grid pattern map decomposition. In addition to some linear strengthening techniques, two mathematic formulations, 4-index and 5-index models, are proposed in the approach and coded in GAMS (Cplex solver. They are tested on a number of problems and the results show that the 5-index model outperforms the 4-index model. Moreover, the proposed system could be significantly improved by the solver-generated cuts, additional constraints, and the variable branching priority extensions.
Assessment of Hydrogen Sulfide Minimum Detection Limits of an Open Path Tunable Diode Laser
During June 2007, U.S. EPA conducted a feasibility study to determine whether the EPA OTM 10 measurement approach, also known as radial plume mapping (RPM), was feasible. A Boreal open-path tunable diode laser (OP-TDL) to collect path-integrated hydrogen sulfide measurements alon...
Englert, Matthias
2009-07-13
This thesis investigates the proliferation resistance of nuclear technologies on the basis of three case studies. After a brief description of the concept of proliferation resistance the utilized computer codes and methods are presented. The first case study investigates the potential of monolithic fuel for the conversion of one-fuel-element high-flux research reactors from highly enriched to low enriched uranium using the example of the german research reactor FRM-II. The second case study assesses the proliferation potential of future tokamak based fusion reactors by using neutronic simulations of a possible plutonium production. The third example investigates the proliferation potential of spallation neutron sources to produce nuclear weapon relevant material and the proliferation resistance of such facilities. (orig.)
Performance Assessment of a Gnss-Based Troposphere Path Delay Estimation Software
Mariotti, Gilles; Avanzi, Alessandro; Graziani, Alberto; Tortora, Paolo
2013-04-01
Error budgets of Deep Space Radio Science experiments are heavily affected by interplanetary and Earth transmission media, that corrupt, due to their non-unitary refraction index, the radiometric information of signals coming from the spacecraft. An effective removal of these noise sources is crucial to achieve the accuracy and signal stability levels required by radio science applications. Depending on the nature of these refractions, transmission media are divided into dispersive (that consists of ionized particles, i.e. Solar Wind and Ionosphere) and non-dispersive ones (the refraction is caused by neutral particles: Earth Troposphere). While dispersive noises are successfully removed by multifrequency combinations (as for GPS with the well-known ionofree combination), the most accurate estimation of tropospheric noise is obtained using microwave radiometers (MWR). As the use of MWRs suffers from strong operational limitations (rain and heavy clouds conditions), the GNSS-based processing is still widely adopted to provide a cost-effective, all-weather condition estimation of the troposphere path delay. This work describes the development process and reports the results of a GNSS analysis code specifically aimed to the estimation of the path delays introduced by the troposphere above deep space complexes, to be used for the calibration of Range and Doppler radiometric data. The code has been developed by the Radio Science Laboratory of the University of Bologna in Forlì, and is currently in the testing phase. To this aim, the preliminary output is compared to MWR measurements and IGS TropoSINEX products in order to assess the reliability of the estimate. The software works using ionofree carrier-phase observables and is based upon a double-difference approach, in which the GNSS receiver placed nearby the Deep Space receiver acts as the rover station. Several baselines are then created with various IGS and EUREF stations (master or reference stations) in order to
Trompezinski S
2016-08-01
Full Text Available Sandra Trompezinski,1 Sophie Weber,1 Benoît Cadars,2 Florence Larue,1 Nathalie Ardiet,1 Marlène Chavagnac-Bonneville,2 Michèle Sayag,2 Eric Jourdan2 1NAOS, Aix-en Provence, 2Direction Scientifique Bioderma (NAOS, Lyon, France Introduction: Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit triggered by Propionibacterium acnes. A bakuchiol, Ginkgo biloba extract, and mannitol (BGM complex has been developed to provide patients with acne with a specific dermocosmetic to be used adjunctively with conventional treatments. Objective: The aim of these studies was to assess the antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its individual compounds as well as its impact on sebum composition. Methods: The antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its compounds was assessed through in vitro, ex vivo, and clinical studies. The clinical benefit of BGM complex formulated in a cream was assessed in subjects prone to acne through sebum composition analysis and photometric assessments. Results: Results from the studies showed that the BGM complex has significant antibacterial, anti-inflammatory, and antioxidative properties. At similar concentrations, bakuchiol has up to twice the antioxidative potential than vitamin E. In subjects, BGM complex regulated the sebum composition in acne patients by increasing the level of sapienic and linolenic acid and reducing the level of oleic acid. The reduced number of porphyrins on the skin surface showed that it is also effective against P. acnes. Conclusion: BGM complex provides a complete adjunctive care in patients with acne by targeting etiopathogenic factors of acne: dysseborrhea, inflammation, and P. acnes proliferation. Keywords: acne, antibacterial, anti-inflammatory, antioxidation, cosmetics, sebum
Kim, Young In; Hahn, Do Hee; Won, Byung Chool; Lee, Dong Uk
2007-11-15
Using the INPRO methodology, the proliferation resistance of an innovative nuclear energy system(INS) defined as a closed nuclear fuel cycle system consisting of KALIMER and pyroprocessing, has been assessed. Considering a very early development stage of the INS concept, the PR assessment is carried out based on intrinsic features, if required information and data are not available. The PR assessment of KALIMER and JSFR using the INPRO methodology affirmed that an adequate proliferation resistance has been achieved in both INSs CNFC-SFR, considering the assessor's progress and maturity of design development. KALIMER and JSFR are developed or being developed conforming to the targets and criteria defined for developing Gen IV nuclear reactor system. Based on these assessment results, proliferation resistance and physical protection(PR and PP) of KALIMER and JSFR are evaluated from the viewpoint of requirements for future nuclear fuel cycle system. The envisioned INSs CNFC-SFR rely on active plutonium management based on a closed fuel cycle, in which a fissile material is recycled in an integrated fuel cycle facility within proper safeguards. There is no isolated plutonium in the closed fuel cycle. The material remains continuously in a sequence of highly radioactive matrices within inaccessible facilities. The proliferation resistance assessment should be an ongoing analysis that keeps up with the progress and maturity of the design of Gen IV SFR.
1979-12-01
This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP.
Mohammad Hajaghazadeh
2012-01-01
Full Text Available Aims: The aim of this study was the investigation of musculoskeletal disorders risk factors among building demolition workers. Materials and Methods: Posture, activity, tools, and handling (PATH method as a work sampling method was applied to record the postures, activities, and handling of building demolition workers in four tasks. The percentage of working time is reported for each item to compare the risk factors in tasks. Nordic musculoskeletal questionnaire also was used to study the prevalence of musculoskeletal disorders over 12 months. Results: Trunk, leg(s, and arm(s postures differed significantly among tasks. Neutral arm posture and non-neutral leg(s and trunk postures were observed frequently. Manual materials handling (MMH activities are distributed differently among tasks. Moving was the most observed (35% and carrying was the less observed (11.8% MMH activity. Gross grasp was the most observed (78.5% hand activity in building demolition workers. The most observed weight category was 0 kg≤load<5 kg. Low back had the highest prevalence of MSDs symptoms (91.1% and hip had the lowest prevalence of symptoms (6.7%. Conclusions: PATH is applicable to building demolition process. Ergonomic intervention is necessary in high prevalence body regions such as lower back and wrist to decrease the symptoms. With respect to the results of PATH method, ergonomic interventions for trunk and leg(s are necessary in all tasks, but only task #3 is in the priority of arm(s intervention.
Shaban parhani
2017-02-01
Full Text Available Construction workers experience a high risk of developing musculoskeletal disorders due to the nature of their jobs. This article aimed to evaluate the risk factors of musculoskeletal disorders among construction workers using Posture, Activity Tools and Handling (PATH. This is a sectional, descriptive-analytical study in a construction site in Tehran, Iran. Certain factors were identified namely body posture, weight of carried tools and objects, activities and tools, and their tasks and activities using PATH. PATH sheets were coded for a certain job. Descriptive data and Chi-square test were employed to analyze the data using SPSS.19. Identification and evaluation were performed in three most important stages of construction: foundation, carcass, finishing (elaborate work. The mean age was 33.08±8.97. Body posture included gentle bending posture (21.2%, severe bending (8.2%, bending and twisting (7% and 1.9%, respectively. Body positions, feet, hands, and weight of tools and objects were significantly different in the working stages (P
Assessment of the beam path deflection for a vertically installed microwave interferometer in SUNIST
Zhong, H.; Ling, B. L.; Tan, Y.; Gao, Z.
2016-08-01
Microwave interferometry has been widely employed to provide reliable line averaged electron density measurement on plasma devices. For a vertically installed interferometer on a tokamak, the refraction problem, which distorts the beam path and aggravates power loss at the receiving antenna, may become significant if taking the cross section shape into account. Increasing the frequency of the probing microwave can alleviate the distortion, but at the expense of losing the density resolution. To seek for an optimized frequency, previous calculations are mainly based on the cylindrical column geometry which grossly underestimates the deflection of the beam path induced by the plasma shape, and empirical suggestions indicating ne0/nc = 1/2 ˜ 1/3 may not always be the appropriate option. Here a single ray tracing method is applied to estimate the final horizontal deviation at the receiving antenna, which is supposed to represent the level of power loss. The calculation is carried out under the real tokamak geometry in Sino-UNIted Spherical Tokamak (SUNIST) with the cross section parameters obtained from the equilibrium reconstruction, and the result indicates that for a target density of 1.2 × 1019 m-3, a frequency of at least 100 GHz is desirable to reduce the power loss to an acceptable level. This would be helpful for the design of a vertically installed interferometer on SUNIST.
Lin, C.C.; Huang, S.J. [National Cheng Kung Univ., Tainan, Taiwan (China). Dept. of Electrical Engineering
2007-07-01
This paper proposed an algorithm to improve the power transmission network in Taiwan which has experienced increased competition since the addition of competitive local exchange carriers (CLEC) into the telecommunication market. Recently, the CLECs requested to rent pipelines from the original incumbent local exchange carriers (ILECs) and from the Taiwan Power Company. The Taiwan Power Company not only builds transmission lines, but also telecommunication networks using different kinds of fiber optic cables, including Optical Power Ground Wire (OPGW), All-Dielectric Self-Supporting (ADSS), and Wrapped types (WOC). This paper also discussed the integration of pipeline rent-out work with AM/FM/geographic information system software. The Java-based software determines a shortest path-planning method for the piping layout to help improve the pipeline system and the construction of an electricity network. The method is expected to increase the use of existing pipelines by improving the efficiency of network planning and maintenance. The method also reduces the potential for design faults and is easy to apply in the field due to the clear criteria. This paper described the proposed system architecture in detail and presented test results. It was shown that the use of a shortest path for the piping layout can reduce the distance between manholes in the huge network. According to test results, the proposed method is considered to be feasible. 11 refs., 2 tabs., 10 figs.
Mark Setterfield
2015-01-01
Path dependency is defined, and three different specific concepts of path dependency – cumulative causation, lock in, and hysteresis – are analyzed. The relationships between path dependency and equilibrium, and path dependency and fundamental uncertainty are also discussed. Finally, a typology of dynamical systems is developed to clarify these relationships.
Ren, Xi; Tapias, Luis F; Jank, Bernhard J; Mathisen, Douglas J; Lanuti, Michael; Ott, Harald C
2015-06-01
Decellularized organ scaffolds allow whole organ regeneration and study of cell behavior in three-dimensional culture conditions. Cell viability within the bio-engineered organ constructs is an essential parameter reflecting the performance of participating cells during long-term ex vivo culture, and is a prerequisite for further functional performance. Resazurin-based redox metabolic assays have been used to monitor cell viability in both two- and three-dimensional cell cultures. Here we developed a method for monitoring cell viability and proliferation in bio-engineered organ constructs using a resazurin perfusion assay. This method allows non-invasive, repetitive and rapid estimation of viable cell numbers during long-term ex vivo culture. As a proof-of-principle, we assessed the performance of two different endothelial sources and the impact of different perfusion programs on endothelial viability after re-endothelialization of decellularized lung scaffolds. The resazurin-based perfusion assay revealed changes in endothelial viability and proliferation during long-term ex vivo culture, which was consistent with histological assessment at different time points. Finally, we showed that this method could be used for assessment of proliferation and cytotoxicity after pharmacological treatment on a three-dimensional non-small cell lung cancer culture model.
Diermeier-Daucher, Simone; Clarke, Scott T; Hill, Dani; Vollmann-Zwerenz, Arabel; Bradford, Jolene A; Brockhoff, Gero
2009-06-01
Using the nucleoside analogue EdU (5-ethynyl-2'-deoxyuridine) for thymidine substitution instead of BrdU (5-bromo-2'-deoxyuridine) in cell proliferation assays has recently been proposed. However, the effect of EdU on cell viability, DNA synthesis, and cell cycle progression and consequently its usability for dynamic cell proliferation analysis in vitro has not been explored. We compared the effect of EdU and BrdU incorporation into SK-BR-3 and BT474 breast cancer cells and the impact on cell cycle kinetics, cell viability, and DNA damage. We found that EdU can be used not only for pulse but also for continuous cell labeling and henceforth in high resolution EdU/Hoechst quenching assays. BrdU and EdU proliferation assays based on click chemistry revealed comparable results. However, cell viability of SK-BR-3 breast cancer cells was highly affected by long term exposure to EdU. Both SK-BR-3 as well as BT474 cells show cell cycle arrests upon long term EdU treatment whereas only SK-BR-3 cells were driven into necrotic cell death by long term exposure to EdU. In contrast BT474 cells appeared essentially unharmed by EdU treatment in terms of viability. Consequently using EdU enables highly sensitive and quantitative detection of proliferating cells and facilitates even continuous cell cycle assessment. Nevertheless, potential cellular susceptibility needs to be individually evaluated.
Assessment of Newcastle Disease specific T cell proliferation in different inbred MHC chicken lines
Norup, Liselotte Rothmann; Dalgaard, Tina Sørensen; Pedersen, Asger Roer;
2011-01-01
In this study we have described the establishment of an antigen-specific T cell proliferation assay based on recall stimulation with Newcastle disease (ND) antigen; further, we have described the results obtained after recall stimulation of animals containing different Major Histocompatibility...
1980-06-01
The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations.
Current process and future path for health economic assessment of pharmaceuticals in France.
Toumi, Mondher; Rémuzat, Cécile; El Hammi, Emna; Millier, Aurélie; Aballéa, Samuel; Chouaid, Christos; Falissard, Bruno
2015-01-01
The Social Security Funding Law for 2012 introduced the Economic and Public Health Assessment Committee (Commission Evaluation Economique et de Santé Publique, or CEESP) in the Social Security Code as a specialised committee affiliated with the Haute Autorité de Santé in charge of providing recommendations and health economic opinions. This article provides an in-depth description of the CEESP's structure and working methods, and analyses the impact of health economic assessment on market access of drugs in France. It also points out the areas of uncertainty and the conflicting rules following the introduction of the health economic assessment in France. The authors also provide their personal opinion on the likely future of health economic assessment of drugs in France, including the possible merge of the CEESP and the Transparency Committee, the implementation of a French threshold, and the extension of health economic assessment to a larger number of products.
Malinger, Gustavo; Lev, Dorit; Lerman-Sagie, Tally
2003-01-01
A considerable number of central nervous system pathologies remain undiagnosed during the first two trimesters of pregnancy. This group of disorders includes anomalies of brain proliferation, migration and cortical organization. Due to the fact that a detailed ultrasound examination of the fetal brain is usually not performed during the third trimester the diagnosis of these disorders is usually only made in families with a previously affected child or in many cases be mere chance. In this article we review the feasibility of prenatal diagnosis of disorders of brain proliferation: microcephaly, macrocephaly, hemimegalencephaly and neoplastic and non-neoplastic abnormal cell types. We discuss the differential diagnosis and offer a stepwise approach to the diagnosis of the more common disorders. PMID:14617366
Lev Dorit
2003-11-01
Full Text Available Abstract A considerable number of central nervous system pathologies remain undiagnosed during the first two trimesters of pregnancy. This group of disorders includes anomalies of brain proliferation, migration and cortical organization. Due to the fact that a detailed ultrasound examination of the fetal brain is usually not performed during the third trimester the diagnosis of these disorders is usually only made in families with a previously affected child or in many cases be mere chance. In this article we review the feasibility of prenatal diagnosis of disorders of brain proliferation: microcephaly, macrocephaly, hemimegalencephaly and neoplastic and non-neoplastic abnormal cell types. We discuss the differential diagnosis and offer a stepwise approach to the diagnosis of the more common disorders.
Diffusion kurtosis imaging can efficiently assess the glioma grade and cellular proliferation
Jiang, Rifeng; Jiang, Jingjing; Zhao, Lingyun; Zhang, Jiaxuan; Zhang, Shun; Yao, Yihao; Yang, Shiqi; Shi, Jingjing; Shen, Nanxi; Su, Changliang; Zhang, Ju; Zhu, Wenzhen
2015-01-01
Conventional diffusion imaging techniques are not sufficiently accurate for evaluating glioma grade and cellular proliferation, which are critical for guiding glioma treatment. Diffusion kurtosis imaging (DKI), an advanced non-Gaussian diffusion imaging technique, has shown potential in grading glioma; however, its applications in this tumor have not been fully elucidated. In this study, DKI and diffusion weighted imaging (DWI) were performed on 74 consecutive patients with histopathologicall...
Assessing the Net Effects of Sanctions on the Proliferation of Weapons of Mass Destruction
2012-12-01
intelligence services to penetrate the IAEA in order to learn how to subvert the inspection process.218 Iraq continued to seek training and outside...2012, http://www.un.org/depts/unmovic/new/documents/resolutions/s-res-1762.pdf. 309Shashank Bengali , “Saddam-era U.N. Sanctions Lifted on Iraq After 20...Proliferation of Nuclear Weapons in the Middle East. Gainesville: Unviversity of Florida Press, 2007. Bengali Shashank, “Saddam-era U.N. Sanctions
Reliability assessment of power distribution systems using disjoint path-set algorithm
Bourezg, Abdrabbi; Meglouli, H.
2015-10-01
Finding the reliability expression of different substation configurations can help design a distribution system with the best overall reliability. This paper presents a computerized a nd implemented algorithm, based on Disjoint Sum of Product (DSOP) algorithm. The algorithm was synthesized and applied for the first time to the determination of reliability expression of a substation to determine reliability indices and costs of different substation arrangements. It deals with the implementation and synthesis of a new designed algorithm for DSOP implemented using C/C++, incorporating parallel problem solving capability and overcoming the disadvantage of Monte Carlo simulation which is the lengthy computational time to achieve satisfactory statistical convergence of reliability index values. The major highlight of this research being that the time consuming procedures of the DSOP solution generated for different substation arrangements using the proposed method is found to be significantly lower in comparison with the time consuming procedures of Monte Carlo-simulation solution or any other method used for the reliability evaluation of substations in the existing literature such as meta-heuristic and soft computing algorithms. This implementation gives the possibility of RBD simulation for different substation configurations in C/C++ using their path-set Boolean expressions mapped to probabilistic domain and result in simplest Sum of Disjoint Product which is on a one-to-one correspondence with reliability expression. This software tool is capable of handling and modeling a large, repairable system. Additionally, through its intuitive interface it can be easily used for industrial and commercial power systems. With simple Boolean expression for a configuration's RBD inputted, users can define a power system utilizing a RBD and, through a fast and efficient built-in simulation engine, the required reliability expressions and indices can be obtained. Two case studies
None
1979-12-01
The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations. While any final assessment of such measures and alternatives would have to examine the circumstances particular to each nation, it is hoped that the more generic assessments conducted here will be useful in suggesting guidelines for developing an improved nonproliferation regime which also helps to meet nuclear-energy needs. One chapter outlines the existing nonproliferation regime, including the Treaty for the Non-Proliferation of Nuclear Weapons (NPT), International Atomic Energy Agency (IAEA) safeguards, bilateral and multilateral requirements for agreements of cooperation and transfers of technology, and existing provisons for sanctions for violation of nonproliferation commitments. The chapter then proceeds to an assessment of various alternatives for providing assurance of fuel supply in light of this current regime. Another chapter examines a set of technical and institutional measures and alternatives for various components of once-through and closed fuel cycles. The components of the once-through fuel cycle assessed are enrichment services and spent-fuel management; the components of closed fuel cycles assessed are reprocessing and plutonium management and fast-breeder reactor (FBR) deployment.
Adopting the Educator’s Mindset: Charting New Paths in Curriculum and Assessment Mapping
Bethany Messersmith
2015-04-01
Full Text Available Throwback Thursday for June 18, 2015: In the Library with the Lead Pipe welcomes Bethany Messersmith to our Editorial Board! In honor of Throwback Thursday, we’re highlighting Bethany’s recent piece on curriculum and assessment mapping. In Brief: The greatest challenge that I faced in my role as Information Literacy Librarian occurred as a result […
Assessment of cell proliferation and prognostic factors in canine mammary gland tumors
A.P. Dutra; G.M. Azevedo Júnior; Schmitt, F. C.; G.D. Cassali
2008-01-01
Three methods for the analysis of cell proliferation, mitotic index/10 high-power fields (10 HPF), mitotic index/four sets of 10 HPF (40 HPF), and MIB-1 index were evaluated in a series of canine mammary gland tumors, as well as the possible correlation between them. Fifty-six canine mammary gland tumors, including 23 benign and 33 malignant, were studied. In addition, the prognostic impact of mitotic index/10 HPF, and histological malignancy grade were evaluated in 17 malignant tumors, being...
Aldemir, Tunc [Ohio State Univ., Columbus, OH (United States); Denning, Richard [Ohio State Univ., Columbus, OH (United States); Catalyurek, Umit [Ohio State Univ., Columbus, OH (United States); Yilmaz, Alper [Ohio State Univ., Columbus, OH (United States); Yue, Meng [Brookhaven National Lab. (BNL), Upton, NY (United States); Cheng, Lap-Yan [Brookhaven National Lab. (BNL), Upton, NY (United States)
2015-01-23
The framework for Proliferation Resistance and Physical Protection (PR & PP) evaluation is to define a set of challenges, to obtain the system responses, and to assess the outcomes. The assessment of outcomes heavily relies on pathways, defined as sequences of events or actions that could potentially be followed by a State or a group of individuals in order to achieve a proliferation objective, with the defined threats as initiating events. There may be large number of segments connecting pathway stages (e.g. acquisition, processing, and fabrication for PR) which can lead to even larger number of pathways or scenarios through possible different combinations of segment connections, each with associated probabilities contributing to the overall risk. Clustering of these scenarios in specified stage attribute intervals is important for their tractable analysis and outcome assessment. A software tool for scenario generation and clustering (OSUPR) is developed that utilizes the PRCALC code developed at the Brookhaven National Laboratory for scenario generation and the K- means, mean shift and adaptive mean shift algorithms as possible clustering schemes. The results of the study using the Example Sodium Fast Breeder as an example system show that clustering facilitates the probabilistic or deterministic analysis of scenarios to identify system vulnerabilities and communication of the major risk contributors to stakeholders. The results of the study also show that the mean shift algorithm has the most potential for assisting the analysis of the scenarios generated by PRCALC.
Pantea Carmen
2010-07-01
Full Text Available The email is a valuable marketing tool for conveying short, simple messages that call for action on behalf of the recipient. Usually companies develop email marketing campaigns for attracting new customers, persuading the existing customers to buy again, encourage customer loyalty, announce or remind about special offers or events. For an email marketing campaign to be efficient, it is wanted a greater number of responses from those in the target. The paper assesses in an exploratory manner the frequency in using the email accounts, the level of exposure to email marketing campaigns as well as the type of information wanted to be received by the Romanian users.
Coleman, Blair N; Rostron, Brian; Johnson, Sarah E; Ambrose, Bridget K; Pearson, Jennifer; Stanton, Cassandra A; Wang, Baoguang; Delnevo, Cristine; Bansal-Travers, Maansi; Kimmel, Heather L; Goniewicz, Maciej L; Niaura, Raymond; Abrams, David; Conway, Kevin P; Borek, Nicolette; Compton, Wilson M; Hyland, Andrew
2017-06-17
Electronic cigarette (e-cigarette) use in the USA is increasing. As such, it is critical to understand who uses e-cigarettes, how e-cigarettes are used and what types of products are prevalent. This study assesses patterns of current e-cigarette use among daily and non-daily adult users in the 2013-2014 Population Assessment of Tobacco and Health (PATH) Study. We examined the proportion of current adult e-cigarette users (n=3642) reporting infrequent use (use on 'some days' and use on 0-2 of the past 30 days), moderate use (use on 'some days' and use on >2 of the past 30 days) and daily use. We examined demographic characteristics, use of other tobacco products and e-cigarette product characteristics overall and by use category. Adjusted prevalence ratios (aPRs) were calculated using Poisson regression to assess correlates of daily e-cigarette use. Among the 5.5% of adult current e-cigarette users in the PATH Study, 42.2% reported infrequent use, 36.5% reported moderate use and 21.3% reported daily use. Cigarette smokers who quit in the past year were more likely to report daily e-cigarette use, compared with current smokers (aPR=3.21, 95% CI=2.75 to 3.76). Those who reported using rechargeable or refillable devices were more likely to report daily use compared with those who did not use these devices (aPR=1.95, 95% CI=1.44 to 2.65 and aPR=2.10, 95% CI=1.75 to 2.52, respectively). The majority of e-cigarette users in this study reported less than daily use. Compared with non-daily use, daily use was associated with being a former smoker; however, cross-sectional data limits our ability to establish the temporality or directionality of such associations. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Walker, Brent; Michaelides, Angelos
2010-11-01
The impact of quantum nuclear effects on hydrogen (H-) bond strength has been inferred in earlier work from bond lengths obtained from path integral molecular dynamics (PIMD) simulations. To obtain a direct quantitative assessment of such effects, we use constrained-centroid PIMD simulations to calculate the free energy changes upon breaking the H-bonds in dimers of HF and water. Comparing ab initio simulations performed using PIMD and classical nucleus molecular dynamics (MD), we find smaller dissociation free energies with the PIMD method. Specifically, at 50 K, the H-bond in (HF)2 is about 30% weaker when quantum nuclear effects are included, while that in (H2O)2 is about 15% weaker. In a complementary set of simulations, we compare unconstrained PIMD and classical nucleus MD simulations to assess the influence of quantum nuclei on the structures of these systems. We find increased heavy atom distances, indicating weakening of the H-bond consistent with that observed by direct calculation of the free energies of dissociation.
Crawford, Susan L.; Cinson, Anthony D.; MacFarlan, Paul J.; Hanson, Brady D.; Mathews, Royce
2012-08-01
The objective of this investigation was to evaluate the efficacy of ultrasonic testing (UT) for primary water leak path assessments of reactor pressure vessel (RPV) upper head penetrations. Operating reactors have experienced leakage when stress corrosion cracking of nickel-based alloy penetrations allowed primary water into the annulus of the interference fit between the penetration and the low-alloy steel RPV head. In this investigation, UT leak path data were acquired for an Alloy 600 control rod drive mechanism nozzle penetration, referred to as Nozzle 63, which was removed from the North Anna Unit 2 reactor when the RPV head was replaced in 2002. In-service inspection prior to the head replacement indicated that Nozzle 63 had a probable leakage path through the interference fit region. Nozzle 63 was examined using a phased-array UT probe with a 5.0-MHz, eight-element annular array. Immersion data were acquired from the nozzle inner diameter surface. The UT data were interpreted by comparing to responses measured on a mockup penetration with known features. Following acquisition of the UT data, Nozzle 63 was destructively examined to determine if the features identified in the UT examination, including leakage paths and crystalline boric acid deposits, could be visually confirmed. Additional measurements of boric acid deposit thickness and low-alloy steel wastage were made to assess how these factors affect the UT response. The implications of these findings for interpreting UT leak path data are described.
Ryschawy, J; Choisis, N; Choisis, J P; Gibon, A
2013-04-01
Mixed crop-livestock systems, combining livestock and cash crops at farm level, are considered to be suitable for sustainable intensification of agriculture. Ensuring the survival of mixed crop-livestock systems is a challenge for European agriculture: the number of European mixed crop-livestock farms has been decreasing since 1970. Analysis of farming system dynamics may elucidate past changes and the forces driving this decline. The objectives of this study were (i) to identify the diversity of paths that allowed the survival of mixed crop-livestock farming and (ii) to elucidate the driving forces behind such survival. We analysed the variety of farm trajectories from 1950 to 2005. We studied the entire farm population of a case study site, located in the 'Coteaux de Gascogne' region. In this less favoured area of south-western France, farmers have limited specialisation. Currently, half of the farms use mixed crop-livestock systems. The data set of 20 variables for 50 farms on the basis of six 10-year time steps was collected through retrospective surveys. We used a two-step analysis including (i) a visual assessment of the whole population of individual farm trajectories and (ii) a computer-based typology of farm trajectories on the basis of a series of multivariate analyses followed by automatic clustering. The European Common Agricultural Policy, market globalisation and decreasing workforce availability were identified as drivers of change that favoured the specialisation process. Nevertheless, farmers' choices and values have opposed against these driving forces, ensuring the survival of some mixed crop-livestock farming systems. The trajectories were clustered into five types, four of which were compatible with mixed crop-livestock systems. The first type was the maximisation of autonomy by combining crops and livestock. The second type was diversification of production to exploit economies of scope and protect the farm against market fluctuations. The
Mireille Bousquet-Mélou
2008-04-01
Full Text Available Let a and b be two positive integers. A culminating path is a path of ℤ 2 that starts from (0,0, consists of steps (1,a and (1,-b, stays above the x-axis and ends at the highest ordinate it ever reaches. These paths were first encountered in bioinformatics, in the analysis of similarity search algorithms. They are also related to certain models of Lorentzian gravity in theoretical physics. We first show that the language on a two letter alphabet that naturally encodes culminating paths is not context-free. Then, we focus on the enumeration of culminating paths. A step by step approach, combined with the kernel method, provides a closed form expression for the generating function of culminating paths ending at a (generic height k. In the case a = b, we derive from this expression the asymptotic behaviour of the number of culminating paths of length n. When a > b, we obtain the asymptotic behaviour by a simpler argument. When a < b, we only determine the exponential growth of the number of culminating paths. Finally, we study the uniform random generation of culminating paths via various methods. The rejection approach, coupled with a symmetry argument, gives an algorithm that is linear when a ≥ b, with no precomputation stage nor non-linear storage required. The choice of the best algorithm is not as clear when a < b. An elementary recursive approach yields a linear algorithm after a precomputation stage involving O (n 3 arithmetic operations, but we also present some alternatives that may be more efficient in practice.
赵著行; 闵应骅; 等
1997-01-01
For different delay models,the concept of sensitization can be very different.Traditonal concepts of sensitization cannot precisely describe circuit behavior when the input vectors change very fast.Using Boolean process aporoach,this paper presents a new definition of sensitization for arbitrary input waveforms.By this new concept it is found that if the inputs of a combinational circuit can change at any time,and each gate's delay varies within an interval (bounded gate delay model),then every path,which is not necessarily a single topological path,is sensitizable.From the experimental results it can be seen that,all nonsensitizable paths for traditional concepts actually can propagate transitions along them for some input waveforms.However,specified time between input transitions(STBIT) and minimum permissible pulse width(ε）are two major factors to make some paths non-sensitizable.
Aimran, Ahmad Nazim; Ahmad, Sabri; Afthanorhan, Asyraf; Awang, Zainudin
2017-05-01
Structural equation modeling (SEM) is the second generation statistical analysis technique developed for analyzing the inter-relationships among multiple variables in a model. Previous studies have shown that there seemed to be at least an implicit agreement about the factors that should drive the choice between covariance-based structural equation modeling (CB-SEM) and partial least square path modeling (PLS-PM). PLS-PM appears to be the preferred method by previous scholars because of its less stringent assumption and the need to avoid the perceived difficulties in CB-SEM. Along with this issue has been the increasing debate among researchers on the use of CB-SEM and PLS-PM in studies. The present study intends to assess the performance of CB-SEM and PLS-PM as a confirmatory study in which the findings will contribute to the body of knowledge of SEM. Maximum likelihood (ML) was chosen as the estimator for CB-SEM and was expected to be more powerful than PLS-PM. Based on the balanced experimental design, the multivariate normal data with specified population parameter and sample sizes were generated using Pro-Active Monte Carlo simulation, and the data were analyzed using AMOS for CB-SEM and SmartPLS for PLS-PM. Comparative Bias Index (CBI), construct relationship, average variance extracted (AVE), composite reliability (CR), and Fornell-Larcker criterion were used to study the consequence of each estimator. The findings conclude that CB-SEM performed notably better than PLS-PM in estimation for large sample size (100 and above), particularly in terms of estimations accuracy and consistency.
JPRS Report, Proliferation Issues
2016-03-24
TECHNICAL INFORMATION SERVICE SPRINGFIELD, VA 22161 PROLIFERATION ISSUES JPRS-TND-93-011 CONTENTS 23 April 1993 [This report contains foreign media ...likely after the U.N. Security [Text] Pyongyang, April 17 (KCNA)-Mass media of the Council adopts its first resolution against Pyongyang United States...his interview to the ARGUMENTY I FAKTY upon the path of confrontation and violence . We do not weekly President Leonid Kravchuk dismissed reports want
Madsen, Mogens Ove
Begrebet Path Dependence blev oprindelig udviklet inden for New Institutionel Economics af bl.a. David, Arthur og North. Begrebet har spredt sig vidt i samfundsvidenskaberne og undergået en udvikling. Dette paper propagerer for at der er sket så en så omfattende udvikling af begrebet, at man nu kan...... tale om 1. og 2. generation af Path Dependence begrebet. Den nyeste udvikling af begrebet har relevans for metodologi-diskusionerne i relation til Keynes...
Maul, B.A.
1979-09-01
The Non-Proliferation Alternative Systems Assessment Program (NASAP) computer code was developed to calculate the LWR and NASAP choice reactor cost through an arbitrary year T/sub N/. The final cost is arrived at by calculation of cost contributory factors for both LWR and NASAP choice reactors.
Kapil, Venkat; Ceriotti, Michele
2016-01-01
The quantum nature of light nuclei influences the structural and dynamic properties of matter up to room temperature and even above. The precise description of such effects in atomistic mod- elling is possible by employing path integral techniques, which involve a considerable computational overhead due to the need of simulating multiple replicas of the system. Many techniques have been suggested to reduce the required number of replicas, including high-order factorizations of the Boltzmann operator, that are particularly attractive for high-precision and low-temperature scenar- ios. Unfortunately, to date several technical challenges have prevented a widespread use of these approaches to study nuclear quantum effects in condensed-phase systems. Here we introduce an inexpensive molecular dynamics scheme that overcomes these limitations, thus making it possible to exploit the improved convergence of high-order path integrals without having to sacrifice the stability, convenience and flexibility of conventional...
Karnøe, Peter; Garud, Raghu
2012-01-01
This paper employs path creation as a lens to follow the emergence of the Danish wind turbine cluster. Supplier competencies, regulations, user preferences and a market for wind power did not pre-exist; all had to emerge in a tranformative manner involving multiple actors and artefacts. Competenc......This paper employs path creation as a lens to follow the emergence of the Danish wind turbine cluster. Supplier competencies, regulations, user preferences and a market for wind power did not pre-exist; all had to emerge in a tranformative manner involving multiple actors and artefacts....... Competencies emerged through processes and mechanisms such as co-creation that implicated multiple learning processes. The process was not an orderly linear one as emergent contingencies influenced the learning processes. An implication is that public policy to catalyse clusters cannot be based...
Rydzewski, J; Nowak, W
2016-04-12
In this work we propose an application of a nonlinear dimensionality reduction method to represent the high-dimensional configuration space of the ligand-protein dissociation process in a manner facilitating interpretation. Rugged ligand expulsion paths are mapped into 2-dimensional space. The mapping retains the main structural changes occurring during the dissociation. The topological similarity of the reduced paths may be easily studied using the Fréchet distances, and we show that this measure facilitates machine learning classification of the diffusion pathways. Further, low-dimensional configuration space allows for identification of residues active in transport during the ligand diffusion from a protein. The utility of this approach is illustrated by examination of the configuration space of cytochrome P450cam involved in expulsing camphor by means of enhanced all-atom molecular dynamics simulations. The expulsion trajectories are sampled and constructed on-the-fly during molecular dynamics simulations using the recently developed memetic algorithms [ Rydzewski, J.; Nowak, W. J. Chem. Phys. 2015 , 143 ( 12 ), 124101 ]. We show that the memetic algorithms are effective for enforcing the ligand diffusion and cavity exploration in the P450cam-camphor complex. Furthermore, we demonstrate that machine learning techniques are helpful in inspecting ligand diffusion landscapes and provide useful tools to examine structural changes accompanying rare events.
Saladino, G; Gauthier, L; Bianciotto, M; Gervasio, F L
2012-04-10
The accurate yet efficient evaluation of the free energy profiles of ligand-target association is a long sought goal in rational drug design. Methods that calculate the free energy along realistic association pathways, such as metadynamics, have been shown to provide reliable profiles, while accounting properly for solvation and target flexibility. However, these approaches usually require prohibitive computational resources and expert human intervention. Here, we show how multiple walkers metadynamics, when performed with optimal path collective variables (PCV), provides in a predetermined amount of computer time an accurate set of free energy profiles for a series of p38 inhibitors. The chosen test set, spanning a wide range of activity, is a challenging benchmark, both for computational methods and for human intuition, as the correct order for the binding affinity cannot be easily guessed. An excellent ranking of the ligands was obtained with minimal human assistance, an important step toward a fully automated pharmaceutical work-flow.
Wassenburg, Stephanie I; de Koning, Björn B; de Vries, Meinou H; van der Schoot, Menno
2016-01-01
Using a component processes task (CPT) that differentiates between higher-level cognitive processes of reading comprehension provides important advantages over commonly used general reading comprehension assessments. The present study contributes to further development of the CPT by evaluating the relative contributions of its components (text memory, text inferencing, and knowledge integration) and working memory to general reading comprehension within a single study using path analyses. Participants were 173 third- and fourth-grade children. As hypothesized, knowledge integration was the only component of the CPT that directly contributed to reading comprehension, indicating that the text-inferencing component did not assess inferential processes related to reading comprehension. Working memory was a significant predictor of reading comprehension over and above the component processes. Future research should focus on finding ways to ensure that the text-inferencing component taps into processes important for reading comprehension.
The need for efficient methods of screening chemicals for the potential to cause developmental neurotoxicity is paramount. We previously described optimization of an HCA assay for proliferation and apoptosis in ReNcell CX cells (ReN), identifying appropriate controls. Utility of ...
To assess the hazards and risks of possible endocrine active chemicals (EACs) there is a need for robust, validated test methods that detect perturbation of endocrine pathways of concern and provide insights reliable information as to assess to potential adverse effects on apical...
Serfontein, Dawid E., E-mail: Dawid.Serfontein@nwu.ac.za [School for Mechanical and Nuclear Engineering, North West University (PUK-Campus), PRIVATE BAG X6001 (Internal Post Box 360), Potchefstroom 2520 (South Africa); Mulder, Eben J. [School for Mechanical and Nuclear Engineering, North West University (South Africa); Reitsma, Frederik [Calvera Consultants (South Africa)
2014-05-01
The approximately 23.7 wt% {sup 240}Pu in reactor-grade plutonium denatures the {sup 239}Pu to the extent that it cannot fuel high yield nuclear weapons. {sup 240}Pu has a high spontaneous fission rate, which increases the spontaneous neutron flux within the fuel. When such a nuclear weapon is triggered, these neutrons cause the nuclear fission chain reaction to pre-detonate which blows the imploding fuel shell apart before the designed level of compression and reactivity could be attained, thereby greatly reducing the average energy yield of such “fizzle” bombs. Therefore reactor-grade plutonium is normally viewed as highly proliferation resistant. In this article the literature on the proliferation resistance of reactor-grade plutonium and on the mechanism and effect of fizzle bombs is reviewed in order to test this view. It is shown that even very low yield fizzle bombs, exploded in urban areas, would still cause serious blast damage as well as radioactive contamination. Combined with the high levels of induced terror, fizzle bombs might thus be attractive psychological weapons for terrorists. Therefore reactor-grade plutonium may not be sufficiently proliferation resistant against nuclear terrorism. However, denaturisation with more than 9% {sup 238}Pu produces high levels of decay heat which will melt or explode the high explosives around uncooled implosion type weapons, rendering them useless. Unfortunately, reactor-grade Pu contains only 2.7% {sup 238}Pu and is thus not sufficiently proliferation resistant in this respect. It is also shown that the associated neptunium poses a substantial proliferation risk. In the present study strong improvement of the proliferation resistance was demonstrated by simulation of incineration of reactor-grade plutonium in the 400 MW{sub th} Pebble Bed Modular Reactor Demonstration Power Plant. Results for modified fuel cycles, aimed at transmutating {sup 237}Np to {sup 238}Pu are also reported. However, these
Froebel, K S; Pakker, N G; Aiuti, F; Bofill, M; Choremi-Papadopoulou, H; Economidou, J; Rabian, C; Roos, M T; Ryder, L P; Miedema, F; Raab, G M
1999-07-30
Lymphocyte proliferation is a widely used technique to assess immune competence. However, the technique is subject to a large degree of variation, some biological and some technical. In this study, the components of variation in whole blood proliferation assays were analysed over time, using both antibody and mitogenic stimulants. The levels of variation within individual samples, between individuals and between groups of individuals over time were examined. A method of transforming the data is proposed which reduces the coefficients of variation to an acceptable level, and which expresses individual results as a standardised count. This method overcomes the problem of different levels of absolute counts, it corrects for time sensitive errors and allows data from multiple laboratories to be pooled.
Manning, Robert M.; Vyhnalek, Brian E.
2015-01-01
The values of the key atmospheric propagation parameters Ct2, Cq2, and Ctq are highly dependent upon the vertical height within the atmosphere thus making it necessary to specify profiles of these values along the atmospheric propagation path. The remote sensing method suggested and described in this work makes use of a rapidly integrating microwave profiling radiometer to capture profiles of temperature and humidity through the atmosphere. The integration times of currently available profiling radiometers are such that they are approaching the temporal intervals over which one can possibly make meaningful assessments of these key atmospheric parameters. Since these parameters are fundamental to all propagation conditions, they can be used to obtain Cn2 profiles for any frequency, including those for an optical propagation path. In this case the important performance parameters of the prevailing isoplanatic angle and Greenwood frequency can be obtained. The integration times are such that Kolmogorov turbulence theory and the Taylor frozen-flow hypothesis must be transcended. Appropriate modifications to these classical approaches are derived from first principles and an expression for the structure functions are obtained. The theory is then applied to an experimental scenario and shows very good results.
Vermeeren, Günter; Joseph, Wout; Martens, Luc
2013-04-01
Assessing the whole-body absorption in a human in a realistic environment requires a statistical approach covering all possible exposure situations. This article describes the development of a statistical multi-path exposure method for heterogeneous realistic human body models. The method is applied for the 6-year-old Virtual Family boy (VFB) exposed to the GSM downlink at 950 MHz. It is shown that the whole-body SAR does not differ significantly over the different environments at an operating frequency of 950 MHz. Furthermore, the whole-body SAR in the VFB for multi-path exposure exceeds the whole-body SAR for worst-case single-incident plane wave exposure by 3.6%. Moreover, the ICNIRP reference levels are not conservative with the basic restrictions in 0.3% of the exposure samples for the VFB at the GSM downlink of 950 MHz. The homogeneous spheroid with the dielectric properties of the head suggested by the IEC underestimates the absorption compared to realistic human body models. Moreover, the variation in the whole-body SAR for realistic human body models is larger than for homogeneous spheroid models. This is mainly due to the heterogeneity of the tissues and the irregular shape of the realistic human body model compared to homogeneous spheroid human body models. Copyright © 2012 Wiley Periodicals, Inc.
Rudolf M. Oosthuizen
2014-06-01
Full Text Available Orientation: Assessing and developing managerial decision-making capability in a complex and volatile marketplace is imperative for most South African businesses.Purpose: The objective of this study was to assess the test–retest reliability of the career path appreciation (CPA procedure in assessing current and potential levels of work decision-making capability. The study also explored whether different gender and race groups differed significantly in terms of these levels at two CPA assessments.Motivation for the study: Limited recent test–retest research has been done regarding the reliability of the CPA technique as a tool for measuring the work decision-making capability of professional and managerial talent in the South African context. Scholars and practitioners in the field of industrial psychology could therefore benefit from follow-up research into the reliability of CPA.Research approach, design and method: The research followed an ex post facto correlational design using longitudinal data of a non-probability purposive sample (N = 527 within the Bioss SA database.Main findings: The results showed that the participants’ first CPA assessment scores correlated significantly and positively with their second CPA assessment scores. Gender and race groups differed significantly in their levels of current work decision-making capability at both assessments.Practical/managerial implications: The CPA procedure can be used with confidence as an assessment tool in the selection, mentoring and development of high-potential managerial and professional talent for diverse gender and race groups.Contribution/value-add: These findings contribute valuable information regarding the reliability of CPA and the differences between race and gender groups in the South African context.
Coady, Katherine K.; Biever, Ronald C.; Denslow, Nancy D.
issue of significant concern to for current EACS screening/testing programs involves resources in regard such as to cost, time, trained personnel, and animal use. This is especially problematic when considering the number of chemicals that some regulatory authorities need to assess. One way to address......To assess the hazards and risks of possible endocrine active chemicals (EACs) there is a need for robust, validated test methods that detect perturbation of endocrine pathways of concern and provide insights reliable information as to assess to potential adverse effects on apical endpoints. One...... practices developed through recent experiences conducting EAC screening/testing. Additionally, the collective assessment of EAC screening and testing data (e.g. compilation of historical control data) can be leveraged to refine test designs and performance criteria to maximize the power and utility of EAC...
Wood, Nathan J.; Schmidtlein, Mathew C.
2012-01-01
Recent disasters highlight the threat that tsunamis pose to coastal communities. When developing tsunami-education efforts and vertical-evacuation strategies, emergency managers need to understand how much time it could take for a coastal population to reach higher ground before tsunami waves arrive. To improve efforts to model pedestrian evacuations from tsunamis, we examine the sensitivity of least-cost-distance models to variations in modeling approaches, data resolutions, and travel-rate assumptions. We base our observations on the assumption that an anisotropic approach that uses path-distance algorithms and accounts for variations in land cover and directionality in slope is the most realistic of an actual evacuation landscape. We focus our efforts on the Long Beach Peninsula in Washington (USA), where a substantial residential and tourist population is threatened by near-field tsunamis related to a potential Cascadia subduction zone earthquake. Results indicate thousands of people are located in areas where evacuations to higher ground will be difficult before arrival of the first tsunami wave. Deviations from anisotropic modeling assumptions substantially influence the amount of time likely needed to reach higher ground. Across the entire study, changes in resolution of elevation data has a greater impact on calculated travel times than changes in land-cover resolution. In particular areas, land-cover resolution had a substantial impact when travel-inhibiting waterways were not reflected in small-scale data. Changes in travel-speed parameters had a substantial impact also, suggesting the importance of public-health campaigns as a tsunami risk-reduction strategy.
Bellande, Bruce J; Winicur, Zev M; Cox, Kathleen M
2010-01-01
Traditional continuing medical education (CME), necessary for keeping physicians current and competent, is insufficient in translating physician practice into better patient outcomes. CME, then, must be transformed from a system of episodic interventions to a more personalized, contextual, flexible, and targeted process within a continuing professional development framework. The core of this transformation must be a formal process of physician self-assessment. Unfortunately, health care providers tend toward inaccurate self-assessment, regardless of training, specialty, or manner of self-assessment. Therefore, the development of an external validation system conducted by credible, informal peer review in a safe environment is essential. Clinicians must be able to access practice and patient data without concerns about accuracy, timeliness, confidentiality, attribution, or unintended consequences. New analytical tools are also needed to illuminate the data compilations and present them in compelling, individualized, and comparative formats. However, such developmental work will not be possible without strong community leadership coordinating a collaboration of resources and a sharing of data. Ensuring physician competence has long been an issue for medical societies, state licensing boards, and others invested in improving patient care. Now it's time to get serious. Current efforts at massive health care reform provide the perfect opportunity to fully integrate physician self-assessment and performance improvement into the larger health care system through a continuing professional development model. Practitioners in CME have been far too complacent with the current practices. A shift to a focused and dedicated sense of urgency must occur to ensure physicians' continuous learning and change.
Mochamad Lazuardi
2008-03-01
Full Text Available Herb medicine have an active substances that can dissolved on polar, semi polar and non polar liquid extract. The methanol and ethyl acetate as a polar and semi polar extract liquid were used to study of herb medicine such as Dendrophthoe species. Diethyl ether as a non polar liquid extract was never use to study the Dendrophthoe species. The aim of this study was to investigate the anti proliferation activity of Dendrophthoe species to myeloma culture cells after extracted by non-polar extract solution (diethyl ether. The post test only control group design was used for this research. A thirty six of microtiterplates wells were used for myeloma culture cells in RPMI medium. The wells were devided placing in two groups: treatment groups and controls groups. Each three wells of six treatment subgroups added with 100 µl of 1.1; 5.5; 11; 22; 33 and 44 µg/ml crude diethyl ether extract series. A RPMI solution at similar method and volume were used as control substances. The cells were assessed by inverted microscope in 200x magnified two days after. The cells were quantified analyzed for anti proliferation activity by using 1:1 methylene blue solution. The results showed that started from 11.0 µg/ml of crude diethyl ether extract of Dendrophthoe species have been anti proliferation abilities of myeloma culture cells (p<0.05. In conclusion, actives substances of Dendrophthoe species where dissolved in non polar liquid as diethyl ether has anti proliferation activities to cancer cell in vitro.
Feynman Path Integrals Over Entangled States
Green, A G; Keeling, J; Simon, S H
2016-01-01
The saddle points of a conventional Feynman path integral are not entangled, since they comprise a sequence of classical field configurations. We combine insights from field theory and tensor networks by constructing a Feynman path integral over a sequence of matrix product states. The paths that dominate this path integral include some degree of entanglement. This new feature allows several insights and applications: i. A Ginzburg-Landau description of deconfined phase transitions. ii. The emergence of new classical collective variables in states that are not adiabatically continuous with product states. iii. Features that are captured in product-state field theories by proliferation of instantons are encoded in perturbative fluctuations about entangled saddles. We develop a general formalism for such path integrals and a couple of simple examples to illustrate their utility.
Mathiassen, Svend Erik
2014-01-01
Objectives: Observational work sampling is often used in occupational studies to assess categorical biomechanical exposures and occurrence of specific work tasks. The statistical performance of data obtained by work sampling is, however, not well understood, impeding informed measurement strategy design. The purpose of this study was to develop a procedure for assessing the statistical properties of work sampling strategies evaluating categorical exposure variables and to illustrate the usefulness of this procedure to examine bias and precision of exposure estimates from samples of different sizes. Methods: From a parent data set of observations on 10 construction workers performing a single operation, the probabilities were determined for each worker of performing four component tasks and working in four mutually exclusive trunk posture categories (neutral, mild flexion, severe flexion, twisted). Using these probabilities, 5000 simulated data sets were created via probability-based resampling for each of six sampling strategies, ranging from 300 to 4500 observations. For each strategy, mean exposure and exposure variability metrics were calculated at both the operation level and task level and for each metric, bias and precision were assessed across the 5000 simulations. Results: Estimates of exposure variability were substantially more uncertain at all sample sizes than estimates of mean exposures and task proportions. Estimates at small sample sizes were also biased. With only 600 samples, proportions of the different tasks and of working with a neutral trunk posture (the most common) were within 10% of the true target value in at least 80% of all the simulated data sets; rarer exposures required at least 1500 samples. For most task-level mean exposure variables and for all operation-level and task-level estimates of exposure variability, performance was low, even with 4500 samples. In general, the precision of mean exposure estimates did not depend on the
Dianne Cmor
2010-03-01
Full Text Available Objective ‐ This study aims to assess student learning with respect to basic database searching at three different points within a required first year course.Methods ‐ Three methods were employed at three different points to identify evidence of successful learning:1. Analysis of in‐class exercises from the initial library workshop, e.g. how many students showed evidence of satisfactorily achieving the stated learning outcomes.2. Participant observation of student presentations, noting themes, strengths and weaknesses of student research strategy; written observation reports from librarians were coded and quantified to identify major themes.3. Interviews with course instructors responsible for grading the final submitted projects, focusing on both student achievement and instructor perceptions of the impact of library involvement.Results ‐ Though performance on in‐class exercises showed evidence of successful learning in over 70% of students, observational data indicated that very few students showed evidence of applying new knowledge and new search skills to their own topics two weeks later. Instructor interviews revealed a perception of similar difficulties in final project submissions, and instructors suggested that students did not appreciate the need for library resources.Conclusion ‐ In this study, students showed evidence of learning in a simulated environment, but were unable or unwilling to demonstrate this learning in authentic situations. Multiple assessment methods reveal a lack of student ability to apply search skills.
PATHS groundwater hydrologic model
Nelson, R.W.; Schur, J.A.
1980-04-01
A preliminary evaluation capability for two-dimensional groundwater pollution problems was developed as part of the Transport Modeling Task for the Waste Isolation Safety Assessment Program (WISAP). Our approach was to use the data limitations as a guide in setting the level of modeling detail. PATHS Groundwater Hydrologic Model is the first level (simplest) idealized hybrid analytical/numerical model for two-dimensional, saturated groundwater flow and single component transport; homogeneous geology. This document consists of the description of the PATHS groundwater hydrologic model. The preliminary evaluation capability prepared for WISAP, including the enhancements that were made because of the authors' experience using the earlier capability is described. Appendixes A through D supplement the report as follows: complete derivations of the background equations are provided in Appendix A. Appendix B is a comprehensive set of instructions for users of PATHS. It is written for users who have little or no experience with computers. Appendix C is for the programmer. It contains information on how input parameters are passed between programs in the system. It also contains program listings and test case listing. Appendix D is a definition of terms.
Coady, Katherine K.; Biever, Ronald C.; Denslow, Nancy D.
issue of significant concern to for current EACS screening/testing programs involves resources in regard such as to cost, time, trained personnel, and animal use. This is especially problematic when considering the number of chemicals that some regulatory authorities need to assess. One way to address......, statistical power to detect biologically significant adverse effects, delivery and analytical measurement of test substances, availability of technical expertise, and study interpretation, including linking mechanistic and apical effects. Some of these areas can be addressed by the lessons learned and best...... screening/testing. Finally, a number of recommendations are provided for longer term research to address areas of uncertainty, including identifying potentially sensitive species for which test methods currently do not exist (e.g., invertebrates) and key endocrine pathways in addition to estrogen, androgen...
Loucougaray, Grégory; Dobremez, Laurent; Gos, Pierre; Pauthenet, Yves; Nettier, Baptiste; Lavorel, Sandra
2015-11-01
Ecological intensification in grasslands can be regarded as a process for increasing forage production while maintaining high levels of ecosystem functions and biodiversity. In the mountain Vercors massif, where dairy cattle farming is the main component of agriculture, how to achieve forage autonomy at farm level while sustaining environmental quality for tourism and local dairy products has recently stimulated local debate. As specific management is one of the main drivers of ecosystem functioning, we assessed the response of forage production and environmental quality at grassland scale across a wide range of management practices. We aimed to determine which components of management can be harnessed to better match forage production and environmental quality. We sampled the vegetation of 51 grasslands stratified across 13 grassland types. We assessed each grassland for agronomic and environmental properties, measuring forage production, forage quality, and indices based on the abundance of particular plant species such as timing flexibility, apiarian potential, and aromatic plants. Our results revealed an expected trade-off between forage production and environmental quality, notably by stressing the contrasts between sown and permanent grasslands. However, strong within-type variability in both production and environmental quality as well as in flexibility of timing of use suggests possible ways to improve this trade-off at grassland and farm scales. As achieving forage autonomy relies on increasing both forage production and grassland resilience, our results highlight the critical role of the ratio between sown and permanent grasslands as a major path for ecological intensification in mountain grasslands.
Loucougaray, Grégory; Dobremez, Laurent; Gos, Pierre; Pauthenet, Yves; Nettier, Baptiste; Lavorel, Sandra
2015-11-01
Ecological intensification in grasslands can be regarded as a process for increasing forage production while maintaining high levels of ecosystem functions and biodiversity. In the mountain Vercors massif, where dairy cattle farming is the main component of agriculture, how to achieve forage autonomy at farm level while sustaining environmental quality for tourism and local dairy products has recently stimulated local debate. As specific management is one of the main drivers of ecosystem functioning, we assessed the response of forage production and environmental quality at grassland scale across a wide range of management practices. We aimed to determine which components of management can be harnessed to better match forage production and environmental quality. We sampled the vegetation of 51 grasslands stratified across 13 grassland types. We assessed each grassland for agronomic and environmental properties, measuring forage production, forage quality, and indices based on the abundance of particular plant species such as timing flexibility, apiarian potential, and aromatic plants. Our results revealed an expected trade-off between forage production and environmental quality, notably by stressing the contrasts between sown and permanent grasslands. However, strong within-type variability in both production and environmental quality as well as in flexibility of timing of use suggests possible ways to improve this trade-off at grassland and farm scales. As achieving forage autonomy relies on increasing both forage production and grassland resilience, our results highlight the critical role of the ratio between sown and permanent grasslands as a major path for ecological intensification in mountain grasslands.
Bölte, Sven; de Schipper, Elles; Holtmann, Martin; Karande, Sunil; de Vries, Petrus J; Selb, Melissa; Tannock, Rosemary
2014-12-01
In the study of health and quality of life in attention deficit/hyperactivity disorder (ADHD), it is of paramount importance to include assessment of functioning. The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive, universally accepted framework for the description of functioning in relation to health conditions. In this paper, the authors outline the process to develop ICF Core Sets for ADHD. ICF Core Sets are subgroups of ICF categories selected to capture the aspects of functioning that are most likely to be affected in specific disorders. The ICF categories that will be included in the ICF Core Sets for ADHD will be determined at an ICF Core Set Consensus Conference, wherein evidence from four preliminary studies (a systematic review, an expert survey, a patient and caregiver qualitative study, and a clinical cross-sectional study) will be integrated. Comprehensive and Brief ICF Core Sets for ADHD will be developed with the goal of providing useful standards for research and clinical practice, and to generate a common language for the description of functioning in ADHD in different areas of life and across the lifespan.
Behrsing, Holger; Raabe, Hans; Manuppello, Joseph; Bombick, Betsy; Curren, Rodger; Sullivan, Kristie; Sethi, Sanjay; Phipps, Richard; Tesfaigzi, Yohannes; Yan, Sherwin; D'Ruiz, Carl; Tarran, Robert; Constant, Samuel; Phillips, Gary; Gaça, Marianna; Hayden, Patrick; Cao, Xuefei; Mathis, Carole; Hoeng, Julia; Braun, Armin; Hill, Erin
2016-05-01
The Family Smoking Prevention and Tobacco Control Act of 2009 established the Food and Drug Administration Center for Tobacco Products (FDA-CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed 'modified risk'. On 8-10 December 2014, IIVS organised a workshop conference, entitled Assessment of In Vitro COPD Models for Tobacco Regulatory Science, to bring together stakeholders representing regulatory agencies, academia, industry and animal protection, to address the research priorities articulated by the FDA-CTP. Specific topics were covered to assess the status of current in vitro technologies as they are applied to understanding the adverse pulmonary events resulting from tobacco product exposure, and in particular, the progression of chronic obstructive pulmonary disease (COPD). The four topics covered were: a) Inflammation and Oxidative Stress; b) Ciliary Dysfunction and Ion Transport; c) Goblet Cell Hyperplasia and Mucus Production; and d) Parenchymal/Bronchial Tissue Destruction and Remodelling. The 2.5 day workshop included 18 expert speakers, plus poster sessions, networking and breakout sessions, which identified key findings and provided recommendations to advance the in vitro technologies and assays used to evaluate tobacco-induced disease etiologies. The workshop summary was reported at the 2015 Society of Toxicology Annual Meeting, and the recommendations led to an IIVS-organised technical workshop in June 2015, entitled Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays, to assess these assays and to conduct a proof-of-principle multi-laboratory exercise to determine their suitability for standardisation. Here, we report on the proceedings, recommendations and outcomes of the December 2014 workshop, including paths forward to continue the development of non-animal methods to evaluate tissue responses that model the disease processes that may lead to COPD, a
Chia-Hung Kao
Full Text Available Chitosan has been widely used in food industry as a weight-loss aid and a cholesterol-lowering agent. Previous studies have shown that chitosan affects metabolic responses and contributes to anti-diabetic, hypocholesteremic, and blood glucose-lowering effects; however, the in vivo targeting sites and mechanisms of chitosan remain to be clarified. In this study, we constructed transgenic mice, which carried the luciferase genes driven by peroxisome proliferator-activated receptor (PPAR, a key regulator of fatty acid and glucose metabolism. Bioluminescent imaging of PPAR transgenic mice was applied to report the organs that chitosan acted on, and gene expression profiles of chitosan-targeted organs were further analyzed to elucidate the mechanisms of chitosan. Bioluminescent imaging showed that constitutive PPAR activities were detected in brain and gastrointestinal tract. Administration of chitosan significantly activated the PPAR activities in brain and stomach. Microarray analysis of brain and stomach showed that several pathways involved in lipid and glucose metabolism were regulated by chitosan. Moreover, the expression levels of metabolism-associated genes like apolipoprotein B (apoB and ghrelin genes were down-regulated by chitosan. In conclusion, these findings suggested the feasibility of PPAR bioluminescent imaging-guided transcriptomic analysis on the evaluation of chitosan-affected metabolic responses in vivo. Moreover, we newly identified that downregulated expression of apoB and ghrelin genes were novel mechanisms for chitosan-affected metabolic responses in vivo.
Demitri, Christian; Grazia Raucci, Maria; Giuri, Antonella; De Benedictis, Vincenzo Maria; Giugliano, Daniela; Calcagnile, Paola; Sannino, Alessandro; Ambrosio, Luigi
2015-10-31
Physical foaming combined with microwave-induced curing was used in this study to develop an innovative device for bone tissue regeneration. In the first step of the process, a stable physical foaming was induced using a surfactant (i.e. pluronic) as blowing agent of a homogeneous blend of Sodium salt of carboxymethylcellulose (CMCNa) and polyethylene glycol diacrylate (PEGDA700) solution. In the second step, the porous structure of the scaffold was chemically stabilized by radical polymerization induced by a homogeneous rapid heating of the sample in a microwave reactor. In this step 2,2-Azobis[2-(2-imidazolin-2 yl)propane]Dihydrochloride was used as thermoinitiator (TI). CMCNa and PEGDA were mixed with different blends to correlate the properties of final product with the composition. The chemical properties of each sample were evaluated by spectroscopy analysis ATR-IR (before and after curing) in order to maximize reaction yield, and optimize kinetic parameters (i.e. time curing, microwave power). The stability of the materials was evaluated in vitro by degradation test in Phosphate Buffered Saline (PBS). Biological analyses were performed to evaluate the effect of scaffold materials on cellular behaviour in terms of proliferation and early osteogenic differentiation of human Mesenchymal Stem Cells (hMSC). This article is protected by copyright. All rights reserved.
1980-06-01
This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest.
Dalgaard, Tina; Norup, Liselotte Rothmann; Rubbenstroth, Dennis
2010-01-01
fetal calf serum with serum-free medium. It was rendered probable that antigen-specific cellular immunity can be assessed by this method as NDV-vaccinated chickens showed a significantly higher proliferative capacity than age-matched naïve controls. Furthermore it was shown that the recall stimulation...
de Visser, R; Blacquière, T
1984-07-01
The contribution of the alternative pathway in root respiration of Pisum sativum L. cv Rondo, Plantago lanceolata L., and Plantago major L. ssp major was determined by titration with salicylhydroxamate (SHAM) in the absence and presence of cyanide. SHAM completely inhibited the cyanide-resistant component of root respiration at 5 to 10 millimolar with an apparent K(i) of 600 micromolar. In contrast, SHAM enhanced pea root respiration by 30% at most, at concentrations below 15 millimolar. An unknown oxidase appeared to be responsible for this stimulation. Its maximum activity in the presence of low SHAM concentrations (1-5 millimolar) was 40% of control respiration rate in pea roots, since 25 millimolar SHAM resulted in 10% inhibition. In plantain roots, the maximum activity was found to be 15%. This hydroxamate-activated oxidase was distinct from the cytochrome path by its resistance to antimycin. The results of titrations with cyanide and antimycin indicated that high SHAM concentrations (up to 25 millimolar) block the hydroxamate-activated oxidase, but do not affect the cytochrome path and, therefore, are a reliable tool for estimating the activity of the alternative path in vivo. A considerable fraction of root respiration was mediated by the alternative path in plantain (45%) and pea (15%), in the latter because of the saturation of the cytochrome path.
Nadeem Akhtar ABBASI; Tariq PERVAIZ; Ishfaq Ahmed HAFIZ; Mehwish YASEEN; Azhar HUSSAIN
2013-01-01
In vitro cultures of loquat cultivar Mardan were established using shoot apices after treating with NaOCl (5％,7％,10％,12％,14％ (v/v)) for 12 min and HgCl2 (0.01％,0.05％,0.10％,0.20％,0.25％ (w/v)) for 2 min.A maximum survival rate of 70％ was recorded after surface sterilization with 10％ NaOCl.Caulogenic response was assessed on Murashige and Skoog (MS) medium fortified with assorted combinations of the cytokinins,benzylaminopurine (BAP),kinetin,and N6-(2-isopentyl)adenine (2iP).Treatment of BAP 1.5 mg/L combined with 2iP 9.0 mg/L and kinetin 1.5 mg/L was found to be optimum for shoot morphogenesis in terms of the number and subsequent growth of shoots,while the highest shoot length was yielded by the combination of BAP 0.5 mg/L,kinetin 0.5 mg/L,and 2iP 3 mg/L.Higher levels of cytokinins induced callogenesis,vitrification and stunted growth to some extent.For rhizogenesis,uniform sized micro-shoots were excised and transferred to half-strength MS medium containing auxins.The best rooting expression was observed with naphthaleneacetic acid (NAA) 1 mg/L combined with indole-3-butyric acid (IBA) 2 mg/L and paclobutrazol (PBZ) 1 mg/L.
Nuclear Proliferation Technology Trends Analysis
Zentner, Michael D.; Coles, Garill A.; Talbert, Robert J.
2005-10-04
A process is underway to develop mature, integrated methodologies to address nonproliferation issues. A variety of methodologies (both qualitative and quantitative) are being considered. All have one thing in common, a need for a consistent set of proliferation related data that can be used as a basis for application. One approach to providing a basis for predicting and evaluating future proliferation events is to understand past proliferation events, that is, the different paths that have actually been taken to acquire or attempt to acquire special nuclear material. In order to provide this information, this report describing previous material acquisition activities (obtained from open source material) has been prepared. This report describes how, based on an evaluation of historical trends in nuclear technology development, conclusions can be reached concerning: (1) The length of time it takes to acquire a technology; (2) The length of time it takes for production of special nuclear material to begin; and (3) The type of approaches taken for acquiring the technology. In addition to examining time constants, the report is intended to provide information that could be used to support the use of the different non-proliferation analysis methodologies. Accordingly, each section includes: (1) Technology description; (2) Technology origin; (3) Basic theory; (4) Important components/materials; (5) Technology development; (6) Technological difficulties involved in use; (7) Changes/improvements in technology; (8) Countries that have used/attempted to use the technology; (9) Technology Information; (10) Acquisition approaches; (11) Time constants for technology development; and (12) Required Concurrent Technologies.
González-Pier, Eduardo; Barraza-Lloréns, Mariana; Beyeler, Naomi; Jamison, Dean; Knaul, Felicia; Lozano, Rafael; Yamey, Gavin; Sepúlveda, Jaime
2016-10-01
The United Nations Sustainable Development Goal for health (SDG3) poses complex challenges for signatory countries that will require clear roadmaps to set priorities over the next 15 years. Building upon the work of the Commission on Investing in Health and published estimates of feasible global mortality SDG3 targets, we analysed Mexico's mortality to assess the feasibility of reducing premature (0-69 years) mortality and propose a path to meet SDG3. We developed a baseline scenario applying 2010 age-specific and cause-specific mortality rates from the Mexican National Institute of Statistics and Geography (INEGI) to the 2030 UN Population Division (UNPD) population projections. In a second scenario, INEGI age-specific and cause-specific trends in death rates from 2000 to 2014 were projected to 2030 and adjusted to match the UNPD 2030 mortality projections. A third scenario assumed a 40% reduction in premature deaths across all ages and causes. By comparing these scenarios we quantified shortfalls in mortality reductions by age group and cause, and forecasted life expectancy pathways for Mexico to converge to better performing countries. UNPD-projected death rates yield a 25·9% reduction of premature mortality for Mexico. Accelerated reductions in adult mortality are necessary to reach a 40% reduction by 2030. Mortality declines aggregated across all age groups mask uneven gains across health disorders. Injuries, particularly road traffic accidents and homicides, are the main health challenge for young adults (aged 20-49 years) whereas unabated diabetes mortality is the single most important health concern for older adults (aged 50-69 years). Urgent action is now required to control non-communicable diseases and reduce fatal injuries in Mexico, making a 40% reduction in premature mortality by 2030 feasible and putting Mexico back on a track of substantial life expectancy convergence with better performing countries. Our study provides a roadmap for setting
Vegetative treatment systems (VTSs) are one type of control structure that has shown potential to control runoff from open feedlots. To achieve maximum performance, sheet-flow over the width of the vegetative treatment area (VTA) is required. Tools, such as maps of flow paths through the VTA, are ne...
Hashmi, Maaz Maqsood; Frate, Ludovico; Nizami, Syed Moazzam; Carranza, Maria Laura
2017-09-07
Mountain environments in the world host highly specialized flora and fauna which are vulnerable because of land use and climate change. Transhumance and other land use traditional practices are present in most of the mountains of the world, and management tools able to cope with new socioeconomic settings and environmental changes are urgently needed. During past centuries, yak (Bos grunniens) herding in Northern Pakistan involved the migration of herds to high mountain international rangelands, but the recent establishment of international borders breaks the traditional transhumance paths, promoting several ecological problems. In this paper, we propose the use of least cost path (LCP) algorithm to identify the most efficient corridors of transhumance for yak herds on northern high altitudes of Pakistan. Specifically, LCP was implemented to identify the critical grazing areas and the connecting zones to be accounted in a new management plan for the yaks in the region. The LCP analysis showed that some grazing areas are connected with several paths, whereas other areas are connected to a lesser extent. The analyses identified a set of best minimum cost paths able to guarantee local connectivity. We also delineated several medium and low efficient paths that could play a crucial role for maintaining regional connectivity which is essential for reducing the isolation of herds and the consequent inbreeding problems. The analytical framework implemented in this study allowed to (1) provide valuable information concerning the movement of yak herds in Gilgit-Baltistan, (2) identify potential corridors that are able to promote herd movement between villages and high mountain rangelands, and (3) identify critical areas for the connectivity of yaks by ranking of the potential corridors according to their length and permeability. The analysis would be extended to other transhumant herds and high mountain areas that are facing sociopolitical transformations and environmental
Path Integrals and Hamiltonians
Baaquie, Belal E.
2014-03-01
1. Synopsis; Part I. Fundamental Principles: 2. The mathematical structure of quantum mechanics; 3. Operators; 4. The Feynman path integral; 5. Hamiltonian mechanics; 6. Path integral quantization; Part II. Stochastic Processes: 7. Stochastic systems; Part III. Discrete Degrees of Freedom: 8. Ising model; 9. Ising model: magnetic field; 10. Fermions; Part IV. Quadratic Path Integrals: 11. Simple harmonic oscillators; 12. Gaussian path integrals; Part V. Action with Acceleration: 13. Acceleration Lagrangian; 14. Pseudo-Hermitian Euclidean Hamiltonian; 15. Non-Hermitian Hamiltonian: Jordan blocks; 16. The quartic potential: instantons; 17. Compact degrees of freedom; Index.
Baras, John
2010-01-01
The algebraic path problem is a generalization of the shortest path problem in graphs. Various instances of this abstract problem have appeared in the literature, and similar solutions have been independently discovered and rediscovered. The repeated appearance of a problem is evidence of its relevance. This book aims to help current and future researchers add this powerful tool to their arsenal, so that they can easily identify and use it in their own work. Path problems in networks can be conceptually divided into two parts: A distillation of the extensive theory behind the algebraic path pr
Multi-Dimensional Path Queries
Bækgaard, Lars
1998-01-01
We present the path-relationship model that supports multi-dimensional data modeling and querying. A path-relationship database is composed of sets of paths and sets of relationships. A path is a sequence of related elements (atoms, paths, and sets of paths). A relationship is a binary path...... to create nested path structures. We present an SQL-like query language that is based on path expressions and we show how to use it to express multi-dimensional path queries that are suited for advanced data analysis in decision support environments like data warehousing environments...
Bessenrodt, Christine; Olsson, Jørn Børling; Sellers, James A.
2013-01-01
We give a complete classification of the unique path partitions and study congruence properties of the function which enumerates such partitions.......We give a complete classification of the unique path partitions and study congruence properties of the function which enumerates such partitions....
Garud, Raghu; Karnøe, Peter
the place of agency in these theories that take history so seriously. In the end, they are as interested in path creation and destruction as they are in path dependence. This book is compiled of both theoretical and empirical writing. It shows relatively well-known industries such as the automobile...
Assari, Amin; Mohammadi, Zargham
2017-09-01
Karst systems show high spatial variability of hydraulic parameters over small distances and this makes their modeling a difficult task with several uncertainties. Interconnections of fractures have a major role on the transport of groundwater, but many of the stochastic methods in use do not have the capability to reproduce these complex structures. A methodology is presented for the quantification of tortuosity using the single normal equation simulation (SNESIM) algorithm and a groundwater flow model. A training image was produced based on the statistical parameters of fractures and then used in the simulation process. The SNESIM algorithm was used to generate 75 realizations of the four classes of fractures in a karst aquifer in Iran. The results from six dye tracing tests were used to assign hydraulic conductivity values to each class of fractures. In the next step, the MODFLOW-CFP and MODPATH codes were consecutively implemented to compute the groundwater flow paths. The 9,000 flow paths obtained from the MODPATH code were further analyzed to calculate the tortuosity factor. Finally, the hydraulic conductivity values calculated from the dye tracing experiments were refined using the actual flow paths of groundwater. The key outcomes of this research are: (1) a methodology for the quantification of tortuosity; (2) hydraulic conductivities, that are incorrectly estimated (biased low) with empirical equations that assume Darcian (laminar) flow with parallel rather than tortuous streamlines; and (3) an understanding of the scale-dependence and non-normal distributions of tortuosity.
Free path groupoid grading on Leavitt path algebras
Goncalves, Daniel; Yoneda, Gabriela
2015-01-01
In this work we realize Leavitt path algebras as partial skew groupoid rings. This yields a free path groupoid grading on Leavitt path algebras. Using this grading we characterize free path groupoid graded isomorphisms of Leavitt path algebras that preserves generators.
高晓光; 李青原; 邸若海
2014-01-01
模型预测控制（model predictive control，MPC）路径规划算法适用于三维动态环境下的无人机（un-manned aerial vehicle，UAV）路径规划；动态贝叶斯网络（dynamic Bayesian network，DBN）能够有效推理战场态势，对无人机进行威胁评估。针对威胁尾随无人机时的路径规划问题，构建 DBN 威胁评估模型，将 UAV 在战场环境中的威胁态势用威胁等级概率表示，与 MPC 路径规划算法相结合，得到基于 DBN 威胁评估的 MPC UAV 路径规划算法。通过多组仿真分析表明，在三维动态环境下，特别是威胁尾随无人机时，基于 DBN 威胁评估的 MPC无人机路径规划算法可以得到有效的无人机路径。%The model predictive control (MPC)path planning algorithm can solve the problem of dynamic unmanned aerial vehicle (UAV)path planning.Dynamic Bayesian network (DBN)is an effective tool for rea-soning and threat assessment.Considering the problem of path planning when the dynamic threat tags the UAV,the MPC path planning algorithm combined with DBN threat assessment is presented,which used the threat lever probability to describe the threat situation.A group of simulations demonstrate the efficiency of MPC three-dimensional dynamic path planning algorithm for UAV based on DBN threat assessment especially when the dynamic threat tags the UAV.
McNab, W. W.; Ramirez, A. L.; Johnson, J.
2011-12-01
A Markov Chain Monte Carlo (MCMC) modeling approach has been developed to identify the distribution of key reactive mineral phases along a flow path between a CO2 injector well and a monitor well at the Weyburn-Midale field in Saskatchewan. The method entailed postulating a spatially-correlated mineral distribution, consisting of calcite, dolomite, anhydrite, and K-feldspar, with specified volume fractions and intrinsic dissolution rates, in contact with an ambient brine composition along a 1-D flow path. Multiple forward reactive transport simulations for the column were run (using PHREEQC for this particular application), with simulated changes in brine chemistry compared with controlled test problem output or real field data. A composite likelihood function was calculated for a set of geochemical parameters consisting of pH and the concentrations of Ca2+, Mg2+, and Si that serves as potential indicators of dissolution reactions along the flow path. New realizations were proposed by replacing a small contiguous section of the column with a new distribution of minerals, but one which was still spatially correlated with the remainder of the column. Proposed realizations were accepted when the ratio of the composite likelihood function value to that of the prior proposal was greater than that of a random number selected from a uniform distribution between 0 and 1 (the well-known Metropolis-Hastings acceptance criteria). If a proposal was accepted, the modified mineral distribution served as the basis for a new distribution, otherwise the modification was rejected as a non-improvement. Application of the inverse modeling approach to a synthetic problem demonstrated nearly complete recovery of a specified initial mineral distribution (i.e., "synthetic truth") along the flow path, provided that parameter data were utilized across the entire column. Partial recovery of the synthetic truth was still achievable as the amount of data available for inversion were reduced to
Path Creation, Path Dependence and Breaking Away from the Path
Wang, Jens Erik; Hedman, Jonas; Tuunainen, Virpi Kristiina
2016-01-01
The explanation of how and why firms succeed or fail is a recurrent research challenge. This is particularly important in the context of technological innovations. We focus on the role of historical events and decisions in explaining such success and failure. Using a case study of Nokia, we develop...... the importance of intermediate outcomes, which in the case of Nokia was the importance of software ecosystems and adaptable mobile devices. Furthermore, we show how the layers of path dependence mutually reinforce each other and become stronger....
Simons, Jacob V., Jr.
2017-01-01
The critical path method/program evaluation and review technique method of project scheduling is based on the importance of managing a project's critical path(s). Although a critical path is the longest path through a network, its location in large projects is facilitated by the computation of activity slack. However, logical fallacies in…
Fabrice, Antigny; Benoît, Ranchoux; Valérie, Nadeau; Lau, Edmund; Sébastien, Bonnet; Frédéric, Perros
2015-01-01
5-Ethynyl-2′-deoxyuridine (EdU) incorporation is becoming the gold standard method for in vitro and in vivo visualization of proliferating cells. The small size of the fluorescent azides used for detection results in a high degree of specimen penetration. It can be used to easily detect DNA replication in large tissue samples or organ explants with low proliferation and turnover of cells formerly believed to be in a “terminal” state of differentiation. Here we describe a protocol for the localization and identification of proliferating cells in quiescent or injured pulmonary vasculature, in a model of pulmonary veno-occlusive disease (PVOD). PVOD is an uncommon form of pulmonary hypertension characterized by progressive obstruction of small pulmonary veins. We previously reported that mitomycin-C (MMC) therapy is associated with PVOD in human. We demonstrated that MMC can induce PVOD in rats, which currently represents the sole animal model that recapitulates human PVOD lesions. Using the EdU assay, we demonstrated that MMC-exposed lungs displayed areas of exuberant microvascular endothelial cell proliferation which mimics pulmonary capillary hemangiomatosis, one of the pathologic hallmarks of human PVOD. In vivo pulmonary cell proliferation measurement represents an interesting methodology to investigate the potential efficacy of therapies aimed at normalizing pathologic angioproliferation. PMID:26345623
Fabrice, Antigny; Benoît, Ranchoux; Valérie, Nadeau; Lau, Edmund; Sébastien, Bonnet; Frédéric, Perros
2015-01-01
5-Ethynyl-2'-deoxyuridine (EdU) incorporation is becoming the gold standard method for in vitro and in vivo visualization of proliferating cells. The small size of the fluorescent azides used for detection results in a high degree of specimen penetration. It can be used to easily detect DNA replication in large tissue samples or organ explants with low proliferation and turnover of cells formerly believed to be in a "terminal" state of differentiation. Here we describe a protocol for the localization and identification of proliferating cells in quiescent or injured pulmonary vasculature, in a model of pulmonary veno-occlusive disease (PVOD). PVOD is an uncommon form of pulmonary hypertension characterized by progressive obstruction of small pulmonary veins. We previously reported that mitomycin-C (MMC) therapy is associated with PVOD in human. We demonstrated that MMC can induce PVOD in rats, which currently represents the sole animal model that recapitulates human PVOD lesions. Using the EdU assay, we demonstrated that MMC-exposed lungs displayed areas of exuberant microvascular endothelial cell proliferation which mimics pulmonary capillary hemangiomatosis, one of the pathologic hallmarks of human PVOD. In vivo pulmonary cell proliferation measurement represents an interesting methodology to investigate the potential efficacy of therapies aimed at normalizing pathologic angioproliferation.
Antigny Fabrice
2015-01-01
Full Text Available 5-Ethynyl-2′-deoxyuridine (EdU incorporation is becoming the gold standard method for in vitro and in vivo visualization of proliferating cells. The small size of the fluorescent azides used for detection results in a high degree of specimen penetration. It can be used to easily detect DNA replication in large tissue samples or organ explants with low proliferation and turnover of cells formerly believed to be in a “terminal” state of differentiation. Here we describe a protocol for the localization and identification of proliferating cells in quiescent or injured pulmonary vasculature, in a model of pulmonary veno-occlusive disease (PVOD. PVOD is an uncommon form of pulmonary hypertension characterized by progressive obstruction of small pulmonary veins. We previously reported that mitomycin-C (MMC therapy is associated with PVOD in human. We demonstrated that MMC can induce PVOD in rats, which currently represents the sole animal model that recapitulates human PVOD lesions. Using the EdU assay, we demonstrated that MMC-exposed lungs displayed areas of exuberant microvascular endothelial cell proliferation which mimics pulmonary capillary hemangiomatosis, one of the pathologic hallmarks of human PVOD. In vivo pulmonary cell proliferation measurement represents an interesting methodology to investigate the potential efficacy of therapies aimed at normalizing pathologic angioproliferation.
Security Guarantees and Nuclear Non-Proliferation
Bruno Tertrais
2011-07-01
The purpose of this paper is to discuss the value of 'security guarantees', that is, positive security assurances that include a formal or informal defense commitment, in preventing nuclear proliferation. It demonstrates that such guarantees have proven to be a very effective instrument in preventing States from going nuclear. It would thus seem logical to reinforce or extend them. However, this path is fraught with obstacles and dilemmas
Tortuous path chemical preconcentrator
Manginell, Ronald P.; Lewis, Patrick R.; Adkins, Douglas R.; Wheeler, David R.; Simonson, Robert J.
2010-09-21
A non-planar, tortuous path chemical preconcentrator has a high internal surface area having a heatable sorptive coating that can be used to selectively collect and concentrate one or more chemical species of interest from a fluid stream that can be rapidly released as a concentrated plug into an analytical or microanalytical chain for separation and detection. The non-planar chemical preconcentrator comprises a sorptive support structure having a tortuous flow path. The tortuosity provides repeated twists, turns, and bends to the flow, thereby increasing the interfacial contact between sample fluid stream and the sorptive material. The tortuous path also provides more opportunities for desorption and readsorption of volatile species. Further, the thermal efficiency of the tortuous path chemical preconcentrator is comparable or superior to the prior non-planar chemical preconcentrator. Finally, the tortuosity can be varied in different directions to optimize flow rates during the adsorption and desorption phases of operation of the preconcentrator.
Charkiewicz, A
2000-01-01
Before the Career Path system, jobs were classified according to grades with general statutory definitions, guided by the "Job Catalogue" which defined 6 evaluation criteria with example illustrations in the form of "typical" job descriptions. Career Paths were given concise statutory definitions necessitating a method of description and evaluation adapted to their new wider-band salary concept. Evaluations were derived from the same 6 criteria but the typical descriptions became unusable. In 1999, a sub-group of the Standing Concertation Committee proposed a new guide for describing Career Paths, adapted to their wider career concept by expanding the 6 evaluation criteria into 9. For each criterion several levels were established tracing the expected evolution of job level profiles and personal competencies over their longer salary ranges. While providing more transparency to supervisors and staff, the Guide's official use would be by services responsible for vacancy notices, Career Path evaluations and rela...
Deepak Goyal
2013-07-01
Full Text Available This paper addresses the malicious node detection and path optimization problem for wireless sensor networks. Malicious node detection in neighborhood is a needed because that node may cause incorrect decisions or energy depletion. In this paper APSO (combination of Artificial bee colony and particular swarm optimization is used to choose an optimized path. Through this improved version we will overcome the disadvantage of local optimal which comes when we use PSO approach.
Bondas, Terese
2006-07-01
The aim was to explore why nurses enter nursing leadership and apply for a management position in health care. The study is part of a research programme in nursing leadership and evidence-based care. Nursing has not invested enough in the development of nursing leadership for the development of patient care. There is scarce research on nurses' motives and reasons for committing themselves to a career in nursing leadership. A strategic sample of 68 Finnish nurse leaders completed a semistructured questionnaire. Analytic induction was applied in an attempt to generate a theory. A theory, Paths to Nursing Leadership, is proposed for further research. Four different paths were found according to variations between the nurse leaders' education, primary commitment and situational factors. They are called the Path of Ideals, the Path of Chance, the Career Path and the Temporary Path. Situational factors and role models of good but also bad nursing leadership besides motivational and educational factors have played a significant role when Finnish nurses have entered nursing leadership. The educational requirements for nurse leaders and recruitment to nursing management positions need serious attention in order to develop a competent nursing leadership.
Kasaj, A.; Willershausen, B.; Junker, R.; Stratul, S.I.; Schmidt, M.
2012-01-01
We determined the effects of soluble or coated nanocrystalline hydroxyapatite paste (nano-HA) and enamel matrix derivative (EMD) on proliferation, adhesion, and migration of periodontal ligament fibroblasts (PDLs). Cultured PDLs were stimulated with nano-HA paste or EMD in a soluble form or were
Schwichtenberg, Fabian; Callies, Ulrich; Groll, Nikolaus; Maßmann, Silvia
2016-06-01
Oil dispersed in the water column remains sheltered from wind forcing, so that an altered drift path is a key consequence of using chemical dispersants. In this study, ensemble simulations were conducted based on 7 years of simulated atmospheric and marine conditions, evaluating 2,190 hypothetical spills from each of 636 cells of a regular grid covering the inner German Bight (SE North Sea). Each simulation compares two idealized setups assuming either undispersed or fully dispersed oil. Differences are summarized in a spatial map of probabilities that chemical dispersant applications would help prevent oil pollution from entering intertidal coastal areas of the Wadden Sea. High probabilities of success overlap strongly with coastal regions between 10 m and 20 m water depth, where the use of chemical dispersants for oil spill response is a particularly contentious topic. The present study prepares the ground for a more detailed net environmental benefit analysis (NEBA) accounting also for toxic effects.
The effect of varying path properties in path steering tasks
Liu, L.; Liere, R. van
2010-01-01
Path steering is a primitive 3D interaction task that requires the user to navigate through a path of a given length and width. In a previous paper, we have conducted controlled experiments in which users operated a pen input device to steer a cursor through a 3D path subject to fixed path propertie
Shortest Paths in Microseconds
Agarwal, Rachit; Godfrey, P Brighten; Zhao, Ben Y
2013-01-01
Computing shortest paths is a fundamental primitive for several social network applications including socially-sensitive ranking, location-aware search, social auctions and social network privacy. Since these applications compute paths in response to a user query, the goal is to minimize latency while maintaining feasible memory requirements. We present ASAP, a system that achieves this goal by exploiting the structure of social networks. ASAP preprocesses a given network to compute and store a partial shortest path tree (PSPT) for each node. The PSPTs have the property that for any two nodes, each edge along the shortest path is with high probability contained in the PSPT of at least one of the nodes. We show that the structure of social networks enable the PSPT of each node to be an extremely small fraction of the entire network; hence, PSPTs can be stored efficiently and each shortest path can be computed extremely quickly. For a real network with 5 million nodes and 69 million edges, ASAP computes a short...
Williams, Virginia Vassilevska
2010-01-01
The replacement paths problem for directed graphs is to find for given nodes s and t and every edge e on the shortest path between them, the shortest path between s and t which avoids e. For unweighted directed graphs on n vertices, the best known algorithm runtime was \\tilde{O}(n^{2.5}) by Roditty and Zwick. For graphs with integer weights in {-M,...,M}, Weimann and Yuster recently showed that one can use fast matrix multiplication and solve the problem in O(Mn^{2.584}) time, a runtime which would be O(Mn^{2.33}) if the exponent \\omega of matrix multiplication is 2. We improve both of these algorithms. Our new algorithm also relies on fast matrix multiplication and runs in O(M n^{\\omega} polylog(n)) time if \\omega>2 and O(n^{2+\\eps}) for any \\eps>0 if \\omega=2. Our result shows that, at least for small integer weights, the replacement paths problem in directed graphs may be easier than the related all pairs shortest paths problem in directed graphs, as the current best runtime for the latter is \\Omega(n^{2.5...
Smoothing of Piecewise Linear Paths
Michel Waringo
2008-11-01
Full Text Available We present an anytime-capable fast deterministic greedy algorithm for smoothing piecewise linear paths consisting of connected linear segments. With this method, path points with only a small influence on path geometry (i.e. aligned or nearly aligned points are successively removed. Due to the removal of less important path points, the computational and memory requirements of the paths are reduced and traversing the path is accelerated. Our algorithm can be used in many different applications, e.g. sweeping, path finding, programming-by-demonstration in a virtual environment, or 6D CNC milling. The algorithm handles points with positional and orientational coordinates of arbitrary dimension.
TRACING EFFICIENT PATH USING WEB PATH TRACING
L.K. Joshila Grace
2014-01-01
Full Text Available In the fast improving society, people depend on online purchase of goods than spending time physically. So there are lots of resources emerged for this online buying and selling of materials. Efficient and attractive web sites would be the best to sell the goods to people. To know whether a web site is reaching the mind of the customers or not, a high speed analysis is done periodically by the web developers. This works helps for the web site developers in knowing the weaker and stronger section of their web site. Parameters like frequency and utility are used for quantitative and qualitative analysis respectively. Addition to this down loads, book marks and the like/dislike of the particular web site is also considered. A new web path trace tree structure is implemented. A mathematical implementation is done to predict the efficient pattern used by the web site visitors.
Li, Fajie
2011-01-01
This unique text/reference reviews algorithms for the exact or approximate solution of shortest-path problems, with a specific focus on a class of algorithms called rubberband algorithms. Discussing each concept and algorithm in depth, the book includes mathematical proofs for many of the given statements. Topics and features: provides theoretical and programming exercises at the end of each chapter; presents a thorough introduction to shortest paths in Euclidean geometry, and the class of algorithms called rubberband algorithms; discusses algorithms for calculating exact or approximate ESPs i
Proliferation Vulnerability Red Team report
Hinton, J.P.; Barnard, R.W.; Bennett, D.E. [and others
1996-10-01
This report is the product of a four-month independent technical assessment of potential proliferation vulnerabilities associated with the plutonium disposition alternatives currently under review by DOE/MD. The scope of this MD-chartered/Sandia-led study was limited to technical considerations that could reduce proliferation resistance during various stages of the disposition processes below the Stored Weapon/Spent Fuel standards. Both overt and covert threats from host nation and unauthorized parties were considered. The results of this study will be integrated with complementary work by others into an overall Nonproliferation and Arms Control Assessment in support of a Secretarial Record of Decision later this year for disposition of surplus U.S. weapons plutonium.
McGarvey, Lynn M.; Sterenberg, Gladys Y.; Long, Julie S.
2013-01-01
The authors elucidate what they saw as three important challenges to overcome along the path to becoming elementary school mathematics teacher leaders: marginal interest in math, low self-confidence, and teaching in isolation. To illustrate how these challenges were mitigated, they focus on the stories of two elementary school teachers--Laura and…
Reparametrizations of Continuous Paths
Fahrenberg, Uli; Raussen, Martin
2007-01-01
compare it to the distributive lattice of countable subsets of the unit interval. The results obtained are used to analyse the space of traces in a topological space, i.e., the space of continuous paths up to reparametrization equivalence. This space is shown to be homeomorphic to the space of regular...
Peter Juhasz
2017-03-01
Full Text Available While risk management gained popularity during the last decades even some of the basic risk types are still far out of focus. One of these is path dependency that refers to the uncertainty of how we reach a certain level of total performance over time. While decision makers are careful in accessing how their position will look like the end of certain periods, little attention is given how they will get there through the period. The uncertainty of how a process will develop across a shorter period of time is often “eliminated” by simply choosing a longer planning time interval, what makes path dependency is one of the most often overlooked business risk types. After reviewing the origin of the problem we propose and compare seven risk measures to access path. Traditional risk measures like standard deviation of sub period cash flows fail to capture this risk type. We conclude that in most cases considering the distribution of the expected cash flow effect caused by the path dependency may offer the best method, but we may need to use several measures at the same time to include all the optimisation limits of the given firm
Assessment of Surgical Path on Zygomatic Complex Fractures%颧骨复合体骨折手术路径探讨
尹刚
2012-01-01
Objective: To summarize the zygomatic complex fracture operation path and their operative effects. Methods: From 2005-11 to 2011-05, in our hospital and maxillofacial surgery department , 76 patients suffered zygomatic complex fractures with surgical reduction were retrospectively analyzed. The selection of incision path were as follows: 4 cases received temporal incision, 2 cases with vestibular sulcus incision, 26 cases with single coronal incision, 18 cases scalp coronal incision + subcilliary incision, 9 cases coronal incision + conjunctival incision, 5 cases scalp coronal incision + oral vestibule incision, 12 cases scalp coronal incision + oral vestibular incision + subciliary incision. Postoperative follow-up period was about 3 years (6-48 months ). Results: 61 cases (80.2% ) completed followed up period. The treatment effect of grade I was observed in 22 cases (36%), grade Ⅱ in 35 cases (57.3%), grade Ⅲ in 4 cases (6.3%). 55 cases (55/61, 90.1%) patients achieved good therapeutic effects. Conclusion: Coronary incision (addition with small incision if necessary), and small local incision alone may be indicated in surgical reduction and achieve satisfactory results.%目的:总结颧骨复合体骨折复位术的手术路径和效果.方法:对2005-11-2011-05在我院颌面外科救治的资料完整的76例颧骨复合体骨折手术病例的手术路径及治疗效果进行回顾性分析.在76例患者中,有4例颞部切口,有2例前庭沟切口,有26例单纯采用头皮冠状切口,有18例采取头皮冠状切口+下睑缘切口,有9例采取头皮冠状切口+结膜囊切口,有5例采取头皮冠状切口+口腔前庭沟切口,有12例采取头皮冠状切口+口腔前庭切口+下睑缘切口.术后随访平均3年(6～48个月).结果:76例患者中随访3年的有61例(80.2％),治疗效果Ⅰ级22例(占36.0％);Ⅱ级35例(占57.3％)；Ⅲ级4例(占6.3％).55例(55/61,90.1％)患者取得了良好的治疗效果.结论:冠状切口(必要
Mochamad Lazuardi
2008-01-01
Herb medicine have an active substances that can dissolved on polar, semi polar and non polar liquid extract. The methanol and ethyl acetate as a polar and semi polar extract liquid were used to study of herb medicine such as Dendrophthoe species. Diethyl ether as a non polar liquid extract was never use to study the Dendrophthoe species. The aim of this study was to investigate the anti proliferation activity of Dendrophthoe species to myeloma culture cells after extracted by non-polar extra...
S.I. Wassenburg (Stephanie); B.B. de Koning (Björn); de Vries, M.H. (Meinou H.); M. van der Schoot (Menno)
2016-01-01
textabstractUsing a component processes task (CPT) that differentiates between higher-level cognitive processes of reading comprehension provides important advantages over commonly used general reading comprehension assessments. The present study contributes to further development of the CPT by eval
Richardson, Emily; Frey, Ruth
2005-01-01
With a fifty-year history of commitment to serving adults, Widener University's University College recently volunteered to participate in CAEL's (Council for Adult and Experiential Learning) Adult Learning Focused Initiative (ALFI) by using the Institutional Self-Assessment Survey (ISAS) and the Adult Learner Inventory (ALI) from the ALFI…
S.I. Wassenburg (Stephanie); B.B. de Koning (Björn); de Vries, M.H. (Meinou H.); van der Schoot, M. (Menno)
2016-01-01
textabstractUsing a component processes task (CPT) that differentiates between higher-level cognitive processes of reading comprehension provides important advantages over commonly used general reading comprehension assessments. The present study contributes to further development of the CPT by eval
Proliferation resistance of small modular reactors fuels
Polidoro, F.; Parozzi, F. [RSE - Ricerca sul Sistema Energetico,Via Rubattino 54, 20134, Milano (Italy); Fassnacht, F.; Kuett, M.; Englert, M. [IANUS, Darmstadt University of Technology, Alexanderstr. 35, D-64283 Darmstadt (Germany)
2013-07-01
In this paper the proliferation resistance of different types of Small Modular Reactors (SMRs) has been examined and classified with criteria available in the literature. In the first part of the study, the level of proliferation attractiveness of traditional low-enriched UO{sub 2} and MOX fuels to be used in SMRs based on pressurized water technology has been analyzed. On the basis of numerical simulations both cores show significant proliferation risks. Although the MOX core is less proliferation prone in comparison to the UO{sub 2} core, it still can be highly attractive for diversion or undeclared production of nuclear material. In the second part of the paper, calculations to assess the proliferation attractiveness of fuel in typical small sodium cooled fast reactor show that proliferation risks from spent fuel cannot be neglected. The core contains a highly attractive plutonium composition during the whole life cycle. Despite some aspects of the design like the sealed core that enables easy detection of unauthorized withdrawal of fissile material and enhances proliferation resistance, in case of open Non-Proliferation Treaty break-out, weapon-grade plutonium in sufficient quantities could be extracted from the reactor core.
Chew, Geoffrey F
2008-01-01
Arrowed-time divergence-free rules or cosmological quantum dynamics are formulated through stepped Feynman paths across macroscopic slices of Milne spacetime. Slice boundaries house totally-relativistic rays representing elementary entities--preons. Total relativity and the associated preon Fock space, despite distinction from special relativity (which lacks time arrow), are based on the Lorentz group. Each path is a set of cubic vertices connected by straight, directed and stepped arcs that carry inertial, electromagnetic and gravitational action. The action of an arc step comprises increments each bounded by Planck's constant. Action from extremely-distant sources is determined by universe mean energy density. Identifying the arc-step energy that determines inertial action with that determining gravitational action establishes both arc-step length and universe density. Special relativity is accurate for physics at laboratory spacetime scales far below that of Hubble and far above that of Planck.
Nonadiabatic transition path sampling
Sherman, M. C.; Corcelli, S. A.
2016-07-01
Fewest-switches surface hopping (FSSH) is combined with transition path sampling (TPS) to produce a new method called nonadiabatic path sampling (NAPS). The NAPS method is validated on a model electron transfer system coupled to a Langevin bath. Numerically exact rate constants are computed using the reactive flux (RF) method over a broad range of solvent frictions that span from the energy diffusion (low friction) regime to the spatial diffusion (high friction) regime. The NAPS method is shown to quantitatively reproduce the RF benchmark rate constants over the full range of solvent friction. Integrating FSSH within the TPS framework expands the applicability of both approaches and creates a new method that will be helpful in determining detailed mechanisms for nonadiabatic reactions in the condensed-phase.
Path planning in dynamic environments
Berg, J.P. van den
2007-01-01
Path planning plays an important role in various fields of application, such as CAD design, computer games and virtual environments, molecular biology, and robotics. In its most general form, the path planning problem is formulated as finding a collision-free path for a moving entity between a start
Graph Coarsening for Path Finding in Cybersecurity Graphs
Hogan, Emilie A.; Johnson, John R.; Halappanavar, Mahantesh
2013-01-01
n the pass-the-hash attack, hackers repeatedly steal password hashes and move through a computer network with the goal of reaching a computer with high level administrative privileges. In this paper we apply graph coarsening in network graphs for the purpose of detecting hackers using this attack or assessing the risk level of the network's current state. We repeatedly take graph minors, which preserve the existence of paths in the graph, and take powers of the adjacency matrix to count the paths. This allows us to detect the existence of paths as well as find paths that have high risk of being used by adversaries.
The path exchange method for hybrid LCA.
Lenzen, Manfred; Crawford, Robert
2009-11-01
Hybrid techniques for Life-Cycle Assessment (LCA) provide a way of combining the accuracy of process analysis and the completeness of input-output analysis. A number of methods have been suggested to implement a hybrid LCA in practice, with the main challenge being the integration of specific process data with an overarching input-output system. In this work we present a new hybrid LCA method which works at the finest input-output level of detail: structural paths. This new Path Exchange method avoids double-counting and system disturbance just as previous hybrid LCA methods, but instead of a large LCA database it requires only a minimum of external information on those structural paths that are to be represented by process data.
Shortest Path Computation with No Information Leakage
Mouratidis, Kyriakos
2012-01-01
Shortest path computation is one of the most common queries in location-based services (LBSs). Although particularly useful, such queries raise serious privacy concerns. Exposing to a (potentially untrusted) LBS the client's position and her destination may reveal personal information, such as social habits, health condition, shopping preferences, lifestyle choices, etc. The only existing method for privacy-preserving shortest path computation follows the obfuscation paradigm; it prevents the LBS from inferring the source and destination of the query with a probability higher than a threshold. This implies, however, that the LBS still deduces some information (albeit not exact) about the client's location and her destination. In this paper we aim at strong privacy, where the adversary learns nothing about the shortest path query. We achieve this via established private information retrieval techniques, which we treat as black-box building blocks. Experiments on real, large-scale road networks assess the pract...
Sam Nicol,; Ruscena Wiederholt,; Diffendorfer, James E.; Brady Mattsson,; Thogmartin, Wayne E.; Semmens, Darius J.; Laura Lopez-Hoffman,; Ryan Norris,
2016-01-01
Mobile species with complex spatial dynamics can be difficult to manage because their population distributions vary across space and time, and because the consequences of managing particular habitats are uncertain when evaluated at the level of the entire population. Metrics to assess the importance of habitats and pathways connecting habitats in a network are necessary to guide a variety of management decisions. Given the many metrics developed for spatially structured models, it can be challenging to select the most appropriate one for a particular decision. To guide the management of spatially structured populations, we define three classes of metrics describing habitat and pathway quality based on their data requirements (graph-based, occupancy-based, and demographic-based metrics) and synopsize the ecological literature relating to these classes. Applying the first steps of a formal decision-making approach (problem framing, objectives, and management actions), we assess the utility of metrics for particular types of management decisions. Our framework can help managers with problem framing, choosing metrics of habitat and pathway quality, and to elucidate the data needs for a particular metric. Our goal is to help managers to narrow the range of suitable metrics for a management project, and aid in decision-making to make the best use of limited resources.
Benardini, James N; Venkateswaran, Kasthuri
2016-12-01
The National Aeronautics and Space Administration (NASA) measures and validates the biological cleanliness of spacecraft surfaces by counting endospores using the NASA standard assay (NSA). NASA has also approved an adenosine-5'-triphosphate (ATP)-based detection methodology as a means to prescreen surfaces for the presence of microbial contamination, prior to the spore assay. During Mars Science Laboratory (MSL) spacecraft assembly, test, and launch operations, 4853 surface samples were collected to verify compliance with the bioburden requirement at launch. A subset of these samples was measured for microbial cleanliness using both the NSA (n = 272) and ATP assay (n = 249). NSA results revealed that ~8% (22/272) of the samples showed the presence of at least one spore, whereas ATP assay measurements indicated that ~15% (35/249) of samples exceeded the "threshold cleanliness limit" of 2.3 × 10(-11) mmol ATP per 25 cm(2) used by MSL. Of the 22 NSA samples with a spore, 18% (4/22) were considered above the level of acceptance by both techniques. Based on post launch data analysis presented here, it was determined that this threshold cleanliness limit of 2.3 × 10(-11) mmol ATP per 25 cm(2) could be adopted as a benchmark for assessing spacecraft surface cleanliness. This study clearly demonstrates the value of using alternative methods to rapidly assess spacecraft cleanliness, and provides useful information regarding the process.
Schürmann, Carsten; Sarnat, Jeffrey
2009-01-01
Programming languages theory is full of problems that reduce to proving the consistency of a logic, such as the normalization of typed lambda-calculi, the decidability of equality in type theory, equivalence testing of traces in security, etc. Although the principle of transfinite induction...... an induction principle that combines the comfort of structural induction with the expressive strength of transfinite induction. Using lexicographic path induction, we give a consistency proof of Martin-Löf’s intuitionistic theory of inductive definitions. The consistency of Heyting arithmetic follows directly...
Mehhtz, Peter
2005-01-01
JPF is an explicit state software model checker for Java bytecode. Today, JPF is a swiss army knife for all sort of runtime based verification purposes. This basically means JPF is a Java virtual machine that executes your program not just once (like a normal VM), but theoretically in all possible ways, checking for property violations like deadlocks or unhandled exceptions along all potential execution paths. If it finds an error, JPF reports the whole execution that leads to it. Unlike a normal debugger, JPF keeps track of every step how it got to the defect.
Jamie Waters
2014-09-01
Full Text Available This project uses Newton’s Second Law of Motion, Euler’s method, basic physics, and basic calculus to model the flight path of a rocket. From this, one can find the height and velocity at any point from launch to the maximum altitude, or apogee. This can then be compared to the actual values to see if the method of estimation is a plausible. The rocket used for this project is modeled after Bullistic-1 which was launched by the Society of Aeronautics and Rocketry at the University of South Florida.
David Middleton
2005-01-01
Full Text Available The hillside’s tidal waves of yellow-green Break downward into full-grown stalks of wheat In which a peasant, shouldering his hoe Passes along a snaking narrow path -- A teeming place through which his hard thighs press And where his head just barely stays above The swaying grain, drunken in abundance, Farm buildings almost floating on the swells Beyond which sea gulls gliding white in air Fly down on out of sight to salty fields, Taking the channel fish off Normandy, A surfeit fit for Eden i...
Darpo, Borje; Garnett, Christine; Benson, Charles T; Keirns, James; Leishman, Derek; Malik, Marek; Mehrotra, Nitin; Prasad, Krishna; Riley, Steve; Rodriguez, Ignacio; Sager, Philip; Sarapa, Nenad; Wallis, Robert
2014-09-01
The International Conference on Harmonization E14 guidance for the clinical evaluation of QT/QTc interval prolongation requires almost all new drugs to undergo a dedicated clinical study, primarily in healthy volunteers, the so-called TQT study. Since 2005, when the E14 guidance was implemented in United States and Europe, close to 400 TQT studies have been conducted. In February 2012, the Cardiac Safety Research Consortium held a think tank meeting at Food and Drug Administration's White Oak campus to discuss whether "QT assessment" can be performed as part of routine phase 1 studies. Based on these discussions, a group of experts convened to discuss how to improve the confidence in QT data from early clinical studies, for example, the First-Time-in-Human trial, through collection of serial electrocardiograms and pharmacokinetic samples and the use of exposure response analysis. Recommendations are given on how to design such "early electrocardiogram assessment," and the limitation of not having a pharmacologic-positive control in these studies is discussed. A research path is identified toward collecting evidence to replace or provide an alternative to the dedicated TQT study.
Path to the Clinic: Assessment of iPSC-Based Cell Therapies In Vivo in a Nonhuman Primate Model
So Gun Hong
2014-05-01
Full Text Available Induced pluripotent stem cell (iPSC-based cell therapies have great potential for regenerative medicine but are also potentially associated with tumorigenic risks. Current rodent models are not optimal predictors of efficiency and safety for clinical application. Therefore, we developed a clinically relevant nonhuman primate model to assess the tumorigenic potential and in vivo efficacy of both undifferentiated and differentiated iPSCs in autologous settings without immunosuppression. Undifferentiated autologous iPSCs indeed form mature teratomas in a dose-dependent manner. However, tumor formation is accompanied by an inflammatory reaction. On the other hand, iPSC-derived mesodermal stromal-like cells form new bone in vivo without any evidence of teratoma formation. We therefore show in a large animal model that closely resembles human physiology that undifferentiated autologous iPSCs form teratomas, and that iPSC-derived progenitor cells can give rise to a functional tissue in vivo.
Wooster, M. J.; Freeborn, P. H.; Archibald, S.; Oppenheimer, C.; Roberts, G. J.; Smith, T. E. L.; Govender, N.; Burton, M.; Palumbo, I.
2011-11-01
Biomass burning emissions factors are vital to quantifying trace gas release from vegetation fires. Here we evaluate emissions factors for a series of savannah fires in Kruger National Park (KNP), South Africa using ground-based open path Fourier transform infrared (FTIR) spectroscopy and an IR source separated by 150-250 m distance. Molecular abundances along the extended open path are retrieved using a spectral forward model coupled to a non-linear least squares fitting approach. We demonstrate derivation of trace gas column amounts for horizontal paths transecting the width of the advected plume, and find for example that CO mixing ratio changes of ~0.01 μmol mol-1 [10 ppbv] can be detected across the relatively long optical paths used here. Though FTIR spectroscopy can detect dozens of different chemical species present in vegetation fire smoke, we focus our analysis on five key combustion products released preferentially during the pyrolysis (CH2O), flaming (CO2) and smoldering (CO, CH4, NH3) processes. We demonstrate that well constrained emissions ratios for these gases to both CO2 and CO can be derived for the backfire, headfire and residual smouldering combustion (RSC) stages of these savannah fires, from which stage-specific emission factors can then be calculated. Headfires and backfires often show similar emission ratios and emission factors, but those of the RSC stage can differ substantially. The timing of each fire stage was identified via airborne optical and thermal IR imagery and ground-observer reports, with the airborne IR imagery also used to derive estimates of fire radiative energy (FRE), allowing the relative amount of fuel burned in each stage to be calculated and "fire averaged" emission ratios and emission factors to be determined. These "fire averaged" metrics are dominated by the headfire contribution, since the FRE data indicate that the vast majority of the fuel is burned in this stage. Our fire averaged emission ratios and factors
M. J. Wooster
2011-11-01
Full Text Available Biomass burning emissions factors are vital to quantifying trace gas release from vegetation fires. Here we evaluate emissions factors for a series of savannah fires in Kruger National Park (KNP, South Africa using ground-based open path Fourier transform infrared (FTIR spectroscopy and an IR source separated by 150–250 m distance. Molecular abundances along the extended open path are retrieved using a spectral forward model coupled to a non-linear least squares fitting approach. We demonstrate derivation of trace gas column amounts for horizontal paths transecting the width of the advected plume, and find for example that CO mixing ratio changes of ~0.01 μmol mol^{−1} [10 ppbv] can be detected across the relatively long optical paths used here. Though FTIR spectroscopy can detect dozens of different chemical species present in vegetation fire smoke, we focus our analysis on five key combustion products released preferentially during the pyrolysis (CH_{2}O, flaming (CO_{2} and smoldering (CO, CH_{4}, NH_{3} processes. We demonstrate that well constrained emissions ratios for these gases to both CO_{2} and CO can be derived for the backfire, headfire and residual smouldering combustion (RSC stages of these savannah fires, from which stage-specific emission factors can then be calculated. Headfires and backfires often show similar emission ratios and emission factors, but those of the RSC stage can differ substantially. The timing of each fire stage was identified via airborne optical and thermal IR imagery and ground-observer reports, with the airborne IR imagery also used to derive estimates of fire radiative energy (FRE, allowing the relative amount of fuel burned in each stage to be calculated and "fire averaged" emission ratios and emission factors to be determined. These "fire averaged" metrics are dominated by the headfire contribution, since the FRE data indicate that the vast majority
Zeini, Miriam; Hortelano, Sonsoles; Través, Paqui G; Gómez-Valadés, Alicia G; Pujol, Anna; Perales, José C; Bartrons, Ramón; Boscá, Lisardo
2005-06-01
The role of hepatic nitric oxide (NO) in liver regeneration after partial hepatectomy (PH) was studied in animals carrying a nitric oxide synthase-2 transgene under the control of the phospho(enol)pyruvate carboxykinase promoter. These mice expressed NOS-2 in liver cells under fasting conditions. Liver mass recovery and molecular parameters related to cell proliferation were determined after PH. Preexisting hepatic NO synthesis, as well as NO delivery by NO-donors, impaired early signaling (for example, attenuated NF-kappaB activation and TNF-alpha and IL-6 release). The regenerative process was also impaired as a result of an insufficient proliferative response, but mouse survival after surgery was not compromised. However, NO exerted a protective role against apoptosis in transgenic hepatectomized mice. Local production of NO in liver cells, achieved by hydrodynamic-based transfection with a NOS-2-encoding plasmid, also resulted in delayed liver recovery after PH and also protected against Fas-mediated apoptosis. These data show that sustained presence of NO after PH exerts a dual role: attenuating liver regeneration while efficiently protecting against liver apoptosis.
Wooster, MJ
2011-01-01
Full Text Available path Fourier transform infrared (FTIR) spectroscopy and an infrared lamp separated by 150–250 m distance. Molecular abundances along the extended open path are retrieved using a spectral forward model coupled to a non-linear least squares fitting...
Romanenko, A.; Zaparin, W.; Vinnichenko, W.; Vozianov, A. (Academy of Medical Sciences of Ukraine, Kiev (Ukraine)); Lee, C.C.R.; Yamamoto, Shinji; Hori, Taka-aki; Wanibuchi, Hideki; Fukushima, Shoji
1999-02-01
During the 11-year period subsequent to the Chernobyl accident, the incidence of urinary bladder cancer in Ukraine has increased from 26.2 to 36.1 per 100,000 population. Cesium-137 ([sup 137]Cs) accounts for 80-90% of the incorporated radioactivity in this population, which has been exposed to long-term, low-dose ionizing radiation, and 80% of the more labile pool of cesium is excreted via the urine. The present study was performed to evaluate the histopathological features and the immunohistochemical status of p53, p21[sup WAF1/Cip1], cyclin D1 and PCNA (proliferating cell nuclear antigen) in urinary bladder mucosa of 55 males (49-92 years old) with benign prostatic hyperplasia who underwent surgery in Kiev, Ukraine, in 1995 and 1996. Group I (28 patients) inhabiting radiocontaminated areas of the country, group II (17 patients) from Kiev city with less radiocontamination and a control group III (10 patients) living in so-called ''clean'' areas of Ukraine were compared. In groups I and II, an increase in multiple areas of moderate or severe dysplasia or carcinoma in situ was seen in 42 (93%) of 45 cases. In addition, two small transitional cell carcinomas were found in one patient in each of groups I and II. Nuclear accumulation of p53, PCNA, cyclin D1, and to a lesser extent p21[sup WAF1/Cip1], was significantly increased in both groups I and II as compared with the control group III, indicating possible transformation events or enhancement of repair activities, that may precede the defect in the regulatory pathway itself, at least in the G1 phase of the cell cycle. Our results suggest that early malignant transformation is taking place in the bladder urothelium of people in the radiocontaminated areas of Ukraine and that this could possibly lead sometime in the future to an increased incidence of urinary bladder cancer. (author)
Path Integrals in Quantum Physics
Rosenfelder, R
2012-01-01
These lectures aim at giving graduate students an introduction to and a working knowledge of path integral methods in a wide variety of fields in physics. Consequently, the lecture notes are organized in three main parts dealing with non-relativistic quantum mechanics, many-body physics and field theory. In the first part the basic concepts of path integrals are developed in the usual heuristic, non-mathematical way followed by standard examples and special applications including numerical evaluation of (euclidean) path integrals by Monte-Carlo methods with a program for the anharmonic oscillator. The second part deals with the application of path integrals in statistical mechanics and many-body problems treating the polaron problem, dissipative quantum systems, path integrals over ordinary and Grassmannian coherent states and perturbation theory for both bosons and fermions. Again a simple Fortran program is included for illustrating the use of strong-coupling methods. Finally, in the third part path integra...
Shortest Paths and Vehicle Routing
Petersen, Bjørn
This thesis presents how to parallelize a shortest path labeling algorithm. It is shown how to handle Chvátal-Gomory rank-1 cuts in a column generation context. A Branch-and-Cut algorithm is given for the Elementary Shortest Paths Problem with Capacity Constraint. A reformulation of the Vehicle R...... Routing Problem based on partial paths is presented. Finally, a practical application of finding shortest paths in the telecommunication industry is shown.......This thesis presents how to parallelize a shortest path labeling algorithm. It is shown how to handle Chvátal-Gomory rank-1 cuts in a column generation context. A Branch-and-Cut algorithm is given for the Elementary Shortest Paths Problem with Capacity Constraint. A reformulation of the Vehicle...
Path integrals for awkward actions
Amdahl, David
2016-01-01
Time derivatives of scalar fields occur quadratically in textbook actions. A simple Legendre transformation turns the lagrangian into a hamiltonian that is quadratic in the momenta. The path integral over the momenta is gaussian. Mean values of operators are euclidian path integrals of their classical counterparts with positive weight functions. Monte Carlo simulations can estimate such mean values. This familiar framework falls apart when the time derivatives do not occur quadratically. The Legendre transformation becomes difficult or so intractable that one can't find the hamiltonian. Even if one finds the hamiltonian, it usually is so complicated that one can't path-integrate over the momenta and get a euclidian path integral with a positive weight function. Monte Carlo simulations don't work when the weight function assumes negative or complex values. This paper solves both problems. It shows how to make path integrals without knowing the hamiltonian. It also shows how to estimate complex path integrals b...
Krenn, Mario; Lahiri, Mayukh; Zeilinger, Anton
2016-01-01
Quantum entanglement is one of the most prominent features of quantum mechanics and forms the basis of quantum information technologies. Here we present a novel method for the creation of quantum entanglement in multipartite and high-dimensional photonic systems, exploiting an idea introduced by the group of Leonard Mandel 25 years ago. The two ingredients are 1) superposition of photon pairs with different origins and 2) aligning photon paths such that they emerge from the same output mode. We explain examples for the creation of various classes of multiphoton entanglement encoded in polarization as well as in high-dimensional Hilbert spaces -- starting only from separable (non-entangled) photon pairs. For two photons, we show how arbitrary high-dimensional entanglement can be created. Interestingly, a common source for two-photon polarization entanglement is found as a special case. We discovered the technique by analyzing the output of a computer algorithm designing quantum experiments, and generalized it ...
Li Jian
2016-01-01
Full Text Available The world has entered the information age, all kinds of information technologies such as cloud technology, big data technology are in rapid development, and the “Internet plus” appeared. The main purpose of “Internet plus” is to provide an opportunity for the further development of the enterprise, the enterprise technology, business and other aspects of factors combine. For enterprises, grasp the “Internet plus” the impact of the market economy will undoubtedly pave the way for the future development of enterprises. This paper will be on the innovation path of the enterprise management “Internet plus” era tied you study, hope to be able to put forward some opinions and suggestions.
Propagators and path integrals
Holten, J.W. van
1995-08-22
Path-integral expressions for one-particle propagators in scalar and fermionic field theories are derived, for arbitrary mass. This establishes a direct connection between field theory and specific classical point-particle models. The role of world-line reparametrization invariance of the classical action and the implementation of the corresponding BRST-symmetry in the quantum theory are discussed. The presence of classical world-line supersymmetry is shown to lead to an unwanted doubling of states for massive spin-1/2 particles. The origin of this phenomenon is traced to a `hidden` topological fermionic excitation. A different formulation of the pseudo-classical mechanics using a bosonic representation of {gamma}{sub 5} is shown to remove these extra states at the expense of losing manifest supersymmetry. (orig.).
Mignemi, S., E-mail: smignemi@unica.it [Dipartimento di Matematica e Informatica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); INFN, Sezione di Cagliari, Cittadella Universitaria, 09042 Monserrato (Italy); Štrajn, R. [Dipartimento di Matematica e Informatica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); INFN, Sezione di Cagliari, Cittadella Universitaria, 09042 Monserrato (Italy)
2016-04-29
The definition of path integrals in one- and two-dimensional Snyder space is discussed in detail both in the traditional setting and in the first-order formalism of Faddeev and Jackiw. - Highlights: • The definition of the path integral in Snyder space is discussed using phase space methods. • The same result is obtained in the first-order formalism of Faddeev and Jackiw. • The path integral formulation of the two-dimensional Snyder harmonic oscillator is outlined.
Path indexing for term retrieval
1992-01-01
Different methods for term retrieval in deduction systems have been introduced in literature. This report eviews the three indexing techniques discrimination indexing, path indexing, and abstraction tree indexing. A formal approach to path indexing is presented and algorithms as well as data structures of an existing implementation are discussed. Eventually, experiments will show that our implementation outperforms the implementation of path indexing in the OTTER theorem prover.
1980-06-01
The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates.
An introduction to critical paths.
Coffey, Richard J; Richards, Janet S; Remmert, Carl S; LeRoy, Sarah S; Schoville, Rhonda R; Baldwin, Phyllis J
2005-01-01
A critical path defines the optimal sequencing and timing of interventions by physicians, nurses, and other staff for a particular diagnosis or procedure. Critical paths are developed through collaborative efforts of physicians, nurses, pharmacists, and others to improve the quality and value of patient care. They are designed to minimize delays and resource utilization and to maximize quality of care. Critical paths have been shown to reduce variation in the care provided, facilitate expected outcomes, reduce delays, reduce length of stay, and improve cost-effectiveness. The approach and goals of critical paths are consistent with those of total quality management (TQM) and can be an important part of an organization's TQM process.
The nuclear proliferation; La proliferation nucleaire
Gere, F. [Ecole Polytechnique, 91 - Palaiseau (France)
1995-04-01
In this book is detailed the beginning of nuclear military power, with the first bomb of Hiroshima, the different ways of getting uranium 235 and plutonium 239, and how the first countries (Usa, Ussr, China, United kingdom, France) got nuclear weapons. Then the most important part is reviewed with the details of non-proliferation treaty and the creation of IAEA to promote civilian nuclear power in the world and to control the use of plutonium and uranium in nuclear power plants. The cases of countries who reached the atom mastery, such Israel, South Africa, Pakistan, Iraq, North Korea, Argentina, Brazil, Iran, Algeria, Taiwan and the reasons which they wanted nuclear weapon for or why they gave up, are exposed.
吕凌; 曾碧
2011-01-01
In order to efficiently solve the problem of mobile robot' s path planning in complex dynamic environment, proposed a new method which implemented parallel ant colony optimization algorithm based on assessment and division-cooperation of labor. This method consists of control center and independent process unit. Each process unit uses division-cooperation of labor ant colony to optimize the ant search in local and global aspect, and then sends the result to the control center. Control center was responsible for coordinating the result which got from each independent process unit and used the assessment mechanism to make final decision. Simulation result shows that this algorithm is feasible and effective.%针对复杂环境中移动机器人的导航中存在的问题,提出了一种适用于机器人路径规划的并行蚁群分工合作算法.该方法由控制中心和独立的运算单元组成,每个运算单元中使用分工合作的蚁群进行计算从而从局部和全局两个方面优化蚁群的路径搜索,并将计算发送给处于控制中心的计算机,控制中心则负责处理每个运算单元发送的阶段性的路径搜索结果并利用评估机制对每个计算机得出的结果做最后的决策.从仿真结果可以看出该算法是有效且可行的.
JPRS Report, Proliferation Issues
2016-03-24
1 Editorials on Faliero’s Parliamentary Address... Parliamentary Address dence-building measures it would promote in the region to realise the objective of non-proliferation. New Delhi Rejects U.S...takes about 250 tonnes of used at Manuguru in the face of advice from juniors that heavy water to run each nuclear reactor. But during the all but a
JPRS Report, Proliferation Issues
2016-03-24
All information has been obtained from foreign radio and television broadcasts, news agency transmissions, newspapers , books, and periodicals. Items...COMMERCE 8NATIONAL TECHNICAL INFORMATION SERVICE ’TIC Q.,’U ’ SPRINGFIELD, VA. 22161 PROLIFERATION ISSUES JPRS-TND-92-023 CONTENTS 16 July 1992 [This...Experts To Tour Azerbaijan ........................................................................................ 12 To Conduct Biochemical Analysis
Battling Nuclear Proliferation
2007-01-01
As the North Korean and Iranian nuclear issues develop and efforts to resolve them continue, global attention to anti-nuclear proliferation and the work of the International Atomic Energy Agency (IAEA) has become even more intense. Pang Sen, Chairman of
JPRS Report, Proliferation Issues
2016-03-24
competence in handling delicate and agricultral projects, medical research, sterilizing issues. tools, and digging oilfields. Electricity Minister Engineer ...CONTENTS 21 October 1992 [This report contains foreign media information on issues related to worldwide proliferation and transfer activities in nuclear...be built by shipping plutonium through the Strait of Malacca, For- the year 2006 to meet the soaring electricity demand, eign Ministry officials said
The Nightmare of Proliferation
PANG SEN; ZHOU WENYI
2010-01-01
@@ The year 2010 unfolded with conflicting developments in the arena of nuclear non-proliferation. Positive news foreshadowed the resumption of the once "dead" six-party talks regarding hostilities on the Korean Peninsula. On the other hand, the Iranian nuclear issue took a downward turn.
Chromatic roots and hamiltonian paths
Thomassen, Carsten
2000-01-01
We present a new connection between colorings and hamiltonian paths: If the chromatic polynomial of a graph has a noninteger root less than or equal to t(n) = 2/3 + 1/3 (3)root (26 + 6 root (33)) + 1/3 (3)root (26 - 6 root (33)) = 1.29559.... then the graph has no hamiltonian path. This result...
Two Generations of Path Dependence
Madsen, Mogens Ove
Even if there is no fully articulated and generally accepted theory of Path Dependence it has eagerly been taken up across a wide range of social sciences - primarily coming from economics. Path Dependence is most of all a metaphor that offers reason to believe, that some political, social...
Hiromi Yamamoto
2005-12-01
Full Text Available The uses of fossil fuels cause not only the resources exhaustion but also the environmental problems such as global warming. The purposes of this study are to evaluate paths toward sustainable energy systems and roles of each renewable. In order to realize the purposes, the authors developed the global land use and energy model that figured the global energy supply systems in the future considering the cost minimization. Using the model, the authors conducted a simulation in C30R scenario, which is a kind of strict CO2 emission limit scenarios and reduced CO2 emissions by 30% compared with Kyoto protocol forever scenario, and obtained the following results. In C30R scenario bioenergy will supply 33% of all the primary energy consumption. However, wind and photovoltaic will supply 1.8% and 1.4% of all the primary energy consumption, respectively, because of the limits of power grid stability. The results imply that the strict limits of CO2 emissions are not sufficient to achieve the complete renewable energy systems. In order to use wind and photovoltaic as major energy resources, we need not only to reduce the plant costs but also to develop unconventional renewable technologies.
Hard paths, soft paths or no paths? Cross-cultural perceptions of water solutions
Wutich, A.; White, A. C.; White, D. D.; Larson, K. L.; Brewis, A.; Roberts, C.
2014-01-01
In this study, we examine how development status and water scarcity shape people's perceptions of "hard path" and "soft path" water solutions. Based on ethnographic research conducted in four semi-rural/peri-urban sites (in Bolivia, Fiji, New Zealand, and the US), we use content analysis to conduct statistical and thematic comparisons of interview data. Our results indicate clear differences associated with development status and, to a lesser extent, water scarcity. People in the two less developed sites were more likely to suggest hard path solutions, less likely to suggest soft path solutions, and more likely to see no path to solutions than people in the more developed sites. Thematically, people in the two less developed sites envisioned solutions that involve small-scale water infrastructure and decentralized, community-based solutions, while people in the more developed sites envisioned solutions that involve large-scale infrastructure and centralized, regulatory water solutions. People in the two water-scarce sites were less likely to suggest soft path solutions and more likely to see no path to solutions (but no more likely to suggest hard path solutions) than people in the water-rich sites. Thematically, people in the two water-rich sites seemed to perceive a wider array of unrealized potential soft path solutions than those in the water-scarce sites. On balance, our findings are encouraging in that they indicate that people are receptive to soft path solutions in a range of sites, even those with limited financial or water resources. Our research points to the need for more studies that investigate the social feasibility of soft path water solutions, particularly in sites with significant financial and natural resource constraints.
1979-12-01
The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials.
2010-01-01
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Takeoff path. 23.57 Section 23.57... path. For each commuter category airplane, the takeoff path is as follows: (a) The takeoff path extends... completed; and (1) The takeoff path must be based on the procedures prescribed in § 23.45; (2) The...
XIANG; Kainan
2001-01-01
［1］ Cruzeiro, A. B., Malliavin, P., Renormalized differential geometry on path spaces: Structural equation, curvature, J. Funct. Anal., 1996, 139: 119-181.［2］ Stroock, D. W., Some thoughts about Riemannian structures on path spaces, preprint, 1996.［3］ Driver, B., A Cameron-Martin type quasi-invariance theorem for Brownian motion on a compact manifold, J. Funct. Anal., 1992, 109: 272-376.［4］ Enchev, O., Stroock, D. W., Towards a Riemannian geometry on the path space over a Riemannian manifold, J. Funct. Anal., 1995, 134: 392-416.［5］ Hsu, E., Quasi-invariance of the Wiener measure on the path space over a compact Riemannian manifold, J. Funct. Anal., 1995, 134: 417-450.［6］ Lyons, T. J., Qian, Z. M., A class of vector fields on path space, J.Funct. Anal., 1997, 145: 205-223.［7］ Li, X. D., Existence and uniqueness of geodesics on path spaces, J. Funct. Anal., to be published.［8］ Driver, B., Towards calculus and geometry on path spaces, in Proc. Symp. Pure and Appl. Math. 57 (ed. Cranston, M., Pinsky, M.), Cornell: AMS, 1993, 1995.
Piao Yunsong [College of Physical Sciences, Graduate School of Chinese Academy of Sciences, Beijing 100049 (China)], E-mail: yspiao@gucas.ac.cn
2009-06-15
In the contracting phase with w{approx_equal}0, the scale invariant spectrum of curvature perturbation is given by the increasing mode of metric perturbation. In this Letter, it is found that if the contracting phase with w{approx_equal}0 is included in each cycle of a cycle universe, since the metric perturbation is amplified on super horizon scale cycle by cycle, after each cycle the universe will be inevitably separated into many parts independent of one another, each of which corresponds to a new universe and evolves up to next cycle, and then is separated again. In this sense, a cyclic multiverse scenario is actually presented, in which the universe proliferates cycle by cycle. We estimate the number of new universes proliferated in each cycle, and discuss the implications of this result.
Preliminary calculation of proliferation resistance of Pyroprocess
Yeop, Joung Sung; Chang, Soon Heung [Korea Advanced Institute Science and Technology, Daejeon (Korea, Republic of)
2010-10-15
We measured the proliferation resistance of Pyroprocess by using multi-attribute utility analysis method. This methodology is intended to allow for the assessment of the effectiveness of safeguards implementation at facilities within a large-scale fuel cycle and allow for the ability to choose technologies based in part on their effectiveness to deter the proliferation of nuclear materials. Pyroprocess may be the part of new Fuel cycle that includes PWR, fuel storage facilities, Pryoprocessing facilities, SFR, fuel repository facilities. In this paper we only focused on Pyroprocessing facilities as a single process
Proliferation Persuasion. Coercive Bargaining with Nuclear Technology
Volpe, Tristan A. [George Washington Univ., Washington, DC (United States)
2015-08-31
Why do states wait for prolonged periods of time with the technical capacity to produce nuclear weapons? Only a handful of countries have ever acquired the sensitive nuclear fuel cycle technology needed to produce fissile material for nuclear weapons. Yet the enduring trend over the last five decades is for these states to delay or forgo exercising the nuclear weapons option provided by uranium enrichment or plutonium reprocessing capabilities. I show that states pause at this threshold stage because they use nuclear technology to bargain for concessions from both allies and adversaries. But when does nuclear latency offer bargaining benefits? My central argument is that challengers must surmount a dilemma to make coercive diplomacy work: the more they threaten to proliferate, the harder it becomes to reassure others that compliance will be rewarded with nuclear restraint. I identify a range of mechanisms able to solve this credibility problem, from arms control over breakout capacity to third party mediation and confidence building measures. Since each step towards the bomb raises the costs of implementing these policies, a state hits a sweet spot when it first acquires enrichment and/or reprocessing (ENR) technology. Subsequent increases in proliferation capability generate diminishing returns at the bargaining table for two reasons: the state must go to greater lengths to make a credible nonproliferation promise, and nuclear programs exhibit considerable path dependency as they mature over time. Contrary to the conventional wisdom about power in world politics, less nuclear latency thereby yields more coercive threat advantages. I marshal new primary source evidence from archives and interviews to identify episodes in the historical record when states made clear decisions to use ENR technology as a bargaining chip, and employ this theory of proliferation persuasion to explain how Japan, North Korea, and Iran succeeded and failed to barter concessions from the
Path integrals and quantum processes
Swanson, Marc S
1992-01-01
In a clearly written and systematic presentation, Path Integrals and Quantum Processes covers all concepts necessary to understand the path integral approach to calculating transition elements, partition functions, and source functionals. The book, which assumes only a familiarity with quantum mechanics, is ideal for use as a supplemental textbook in quantum mechanics and quantum field theory courses. Graduate and post-graduate students who are unfamiliar with the path integral will also benefit from this contemporary text. Exercise sets are interspersed throughout the text to facilitate self-
Path Integration in Conical Space
Inomata, Akira; Junker, Georg
2011-01-01
Quantum mechanics in conical space is studied by the path integral method. It is shown that the curvature effect gives rise to an effective potential in the radial path integral. It is further shown that the radial path integral in conical space can be reduced to a form identical with that in flat space when the discrete angular momentum of each partial wave is replaced by a specific non-integral angular momentum. The effective potential is found proportional to the squared mean curvature of ...
On the Reaction Path Hamiltonian
孙家钟; 李泽生
1994-01-01
A vector-fiber bundle structure of the reaction path Hamiltonian, which has been introduced by Miller, Handy and Adams, is explored with respect to molecular vibrations orthogonal to the reaction path. The symmetry of the fiber bundle is characterized by the real orthogonal group O(3N- 7) for the dynamical system with N atoms. Under the action of group O(3N- 7). the kinetic energy of the reaction path Hamiltonian is left invariant. Furthermore , the invariant behaviour of the Hamiltonian vector fields is investigated.
vanden-Eijnden, E.
The dynamical behavior of many systems arising in physics, chemistry, biology, etc. is dominated by rare but important transition events between long lived states. For over 70 years, transition state theory (TST) has provided the main theoretical framework for the description of these events [17,33,34]. Yet, while TST and evolutions thereof based on the reactive flux formalism [1, 5] (see also [30,31]) give an accurate estimate of the transition rate of a reaction, at least in principle, the theory tells very little in terms of the mechanism of this reaction. Recent advances, such as transition path sampling (TPS) of Bolhuis, Chandler, Dellago, and Geissler [3, 7] or the action method of Elber [15, 16], may seem to go beyond TST in that respect: these techniques allow indeed to sample the ensemble of reactive trajectories, i.e. the trajectories by which the reaction occurs. And yet, the reactive trajectories may again be rather uninformative about the mechanism of the reaction. This may sound paradoxical at first: what more than actual reactive trajectories could one need to understand a reaction? The problem, however, is that the reactive trajectories by themselves give only a very indirect information about the statistical properties of these trajectories. This is similar to why statistical mechanics is not simply a footnote in books about classical mechanics. What is the probability density that a trajectory be at a given location in state-space conditional on it being reactive? What is the probability current of these reactive trajectories? What is their rate of appearance? These are the questions of interest and they are not easy to answer directly from the ensemble of reactive trajectories. The right framework to tackle these questions also goes beyond standard equilibrium statistical mechanics because of the nontrivial bias that the very definition of the reactive trajectories imply - they must be involved in a reaction. The aim of this chapter is to
Scattering theory with path integrals
Rosenfelder, R. [Particle Theory Group, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)
2014-03-15
Starting from well-known expressions for the T-matrix and its derivative in standard nonrelativistic potential scattering, I rederive recent path-integral formulations due to Efimov and Barbashov et al. Some new relations follow immediately.
Scattering Theory with Path Integrals
Rosenfelder, R
2013-01-01
Starting from well-known expressions for the $T$-matrix and its derivative in standard nonrelativistic potential scattering I rederive recent path-integral formulations due to Efimov and Barbashov et al. Some new relations follow immediately.
The Internet's unexploited path diversity
Arjona-Villicaña, Pedro David; Stepanenko, Alexander S
2009-01-01
The connectivity of the Internet at the Autonomous System level is influenced by the network operator policies implemented. These in turn impose a direction to the announcement of address advertisements and, consequently, to the paths that can be used to reach back such destinations. We propose to use directed graphs to properly represent how destinations propagate through the Internet and the number of arc-disjoint paths to quantify this network's path diversity. Moreover, in order to understand the effects that policies have on the connectivity of the Internet, numerical analyses of the resulting directed graphs were conducted. Results demonstrate that, even after policies have been applied, there is still path diversity which the Border Gateway Protocol cannot currently exploit.
An Introduction to Path Analysis
Wolfe, Lee M.
1977-01-01
The analytical procedure of path analysis is described in terms of its use in nonexperimental settings in the social sciences. The description assumes a moderate statistical background on the part of the reader. (JKS)
Equivariant Localization of Path Integrals
Szabo, Richard J.
1996-01-01
We review equivariant localization techniques for the evaluation of Feynman path integrals. We develop systematic geometric methods for studying the semi-classical properties of phase space path integrals for dynamical systems, emphasizing the relations with integrable and topological quantum field theories. Beginning with a detailed review of the relevant mathematical background -- equivariant cohomology and the Duistermaat-Heckman theorem, we demonstrate how the localization ideas are relat...
Path Integrals in Quantum Physics
2012-01-01
These lectures aim at giving graduate students an introduction to and a working knowledge of path integral methods in a wide variety of fields in physics. Consequently, the lecture notes are organized in three main parts dealing with non-relativistic quantum mechanics, many-body physics and field theory. In the first part the basic concepts of path integrals are developed in the usual heuristic, non-mathematical way followed by standard examples and special applications including numerical ev...
Formal language constrained path problems
Barrett, C.; Jacob, R.; Marathe, M.
1997-07-08
In many path finding problems arising in practice, certain patterns of edge/vertex labels in the labeled graph being traversed are allowed/preferred, while others are disallowed. Motivated by such applications as intermodal transportation planning, the authors investigate the complexity of finding feasible paths in a labeled network, where the mode choice for each traveler is specified by a formal language. The main contributions of this paper include the following: (1) the authors show that the problem of finding a shortest path between a source and destination for a traveler whose mode choice is specified as a context free language is solvable efficiently in polynomial time, when the mode choice is specified as a regular language they provide algorithms with improved space and time bounds; (2) in contrast, they show that the problem of finding simple paths between a source and a given destination is NP-hard, even when restricted to very simple regular expressions and/or very simple graphs; (3) for the class of treewidth bounded graphs, they show that (i) the problem of finding a regular language constrained simple path between source and a destination is solvable in polynomial time and (ii) the extension to finding context free language constrained simple paths is NP-complete. Several extensions of these results are presented in the context of finding shortest paths with additional constraints. These results significantly extend the results in [MW95]. As a corollary of the results, they obtain a polynomial time algorithm for the BEST k-SIMILAR PATH problem studied in [SJB97]. The previous best algorithm was given by [SJB97] and takes exponential time in the worst case.
Asteroidal Quadruples in non Rooted Path Graphs
Gutierrez Marisa
2015-11-01
Full Text Available A directed path graph is the intersection graph of a family of directed subpaths of a directed tree. A rooted path graph is the intersection graph of a family of directed subpaths of a rooted tree. Rooted path graphs are directed path graphs. Several characterizations are known for directed path graphs: one by forbidden induced subgraphs and one by forbidden asteroids. It is an open problem to find such characterizations for rooted path graphs. For this purpose, we are studying in this paper directed path graphs that are non rooted path graphs. We prove that such graphs always contain an asteroidal quadruple.
Axonal lesion-induced microglial proliferation and microglial cluster formation in the mouse
Dissing-Olesen, L; Ladeby, R; Nielsen, Helle Hvilsted;
2007-01-01
Microglia are innate immune cells and form the first line of defense of the CNS. Proliferation is a key event in the activation of microglia in acute pathology, and has been extensively characterized in rats, but not in mice. In this study we investigated axonal-lesion-induced microglial...... proliferation and surface antigen expression in C57BL/6 mice. Transection of the entorhino-dentate perforant path projection results in an anterograde axonal and a dense terminal degeneration that induces a region-specific activation of microglia in the dentate gyrus. Time-course analysis showed activation...... and the proliferation marker bromodeoxyuridine, injected 1 h prior to perfusion, showed that lesion-reactive microglia accounted for the vast majority of proliferating cells. Microglia proliferated as soon as 24 h after lesion and 25% of all microglial cells were proliferating 3 days post-lesion. Immunofluorescence...
JPRS Report: Proliferation Issues
2016-03-24
Industry (MITI) plans to hold a seminar on arms export control as early as this fall in an Asian country. The countries include Indonesia, Malaysia ...NPT BK1703072393 Kuala Lumpur BERNAMA in English 0604 GMT 17 Mar 93 [Text] Kuala Lumpur, March 17 (OANA/ BERNAMA)— Malaysia Wednesday, expressed ...JPRS-TND-93-009 29 March 1993 !■■■■! FOREIGN BROADCAST INFORMATION SERVICE JPRS Report— Proliferation Issues Sapsevsd tea ßubSa t©l©ɛ
Anomalous paths in quantum mechanical path-integrals
Grimsmo, Arne L., E-mail: arne.grimsmo@ntnu.no [Department of Physics, The Norwegian University of Science and Technology, N-7491 Trondheim (Norway); Department of Physics, The University of Auckland, Private Bag 92019, Auckland (New Zealand); Klauder, John R., E-mail: klauder@phys.ufl.edu [Departments of Physics and Mathematics, University of Florida, Gainesville, FL 32611 (United States); Skagerstam, Bo-Sture K., E-mail: bo-sture.skagerstam@ntnu.no [Department of Physics, The Norwegian University of Science and Technology, N-7491 Trondheim (Norway); Kavli Institute for Theoretical Physics, Kohn Hall, University of California at Santa Barbara, CA 93106-4030 (United States); CREOL, The College of Optics and Photonics at the University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL 32816 (United States)
2013-11-25
We investigate modifications of the discrete-time lattice action, for a quantum mechanical particle in one spatial dimension, that vanish in the naïve continuum limit but which, nevertheless, induce non-trivial effects due to quantum fluctuations. These effects are seen to modify the geometry of the paths contributing to the path-integral describing the time evolution of the particle, which we investigate through numerical simulations. In particular, we demonstrate the existence of a modified lattice action resulting in paths with any fractal dimension, d{sub f}, between one and two. We argue that d{sub f}=2 is a critical value, and we exhibit a type of lattice modification where the fluctuations in the position of the particle becomes independent of the time step, in which case the paths are interpreted as superdiffusive Lévy flights. We also consider the jaggedness of the paths, and show that this gives an independent classification of lattice theories.
赵隆
2016-01-01
Under the impact of global warming and ice-melting, Arctic issue be-came with more effect of diffusion in recent years, the possible economical ad-vantage of Northern Sea Route (NSR) have been discussed broadly. In the context of internal and external demands, Russia has practiced selective compromise governance path based on the principle of limited opening, initiates proactive compromise on issues such as navigation rules and infrastructure building, us-ing the NSR as a response to external challenges and new growth-point of domes-tic demand. However, behind current limited data of NSR exists so called one-sidedness of shipping demands and economical hypothesis, which reflects lack of knowledge in climate change, hydrology and meteorology, maritime secu-rity, pollution control and other uncertain factors assessment, the commercial shipping and investment conditions of NSR in the short-terms are limited.%随着气候变暖及融冰加剧，近年来北极问题的影响逐步扩散，北方航道的预期经济性也引发关于大规模开发利用的讨论。在内外需求交织的背景下，俄罗斯以“有限开放”原则为基础采取“选择性妥协”治理路径，在航行规则和基础设施建设等问题上主动妥协，努力将北方航道作为应对外部挑战和国内发展需求的新增长点。北方航道有限的数据背后反映出航运需求和经济性预期的片面性，且缺乏对自然条件、航运安全、污染防控等多重不确定因素评估，在短期内尚不具备大规模商业通航和投资的条件。以季节性运输及试航积累冰区航行经验，以港口基建为路径配置资金技术输出，以航运企业为主体主动配合俄罗斯战略调整需求，或是我国参与北方航道事务的优选方案。
Initiatives for proliferation prevention
NONE
1997-04-01
Preventing the proliferation of weapons of mass destruction is a central part of US national security policy. A principal instrument of the Department of Energy`s (DOE`s) program for securing weapons of mass destruction technology and expertise and removing incentives for scientists, engineers and technicians in the newly independent states (NIS) of the former Soviet Union to go to rogue countries or assist terrorist groups is the Initiatives for Proliferation Prevention (IPP). IPP was initiated pursuant to the 1994 Foreign Operations Appropriations Act. IPP is a nonproliferation program with a commercialization strategy. IPP seeks to enhance US national security and to achieve nonproliferation objectives by engaging scientists, engineers and technicians from former NIS weapons institutes; redirecting their activities in cooperatively-developed, commercially viable non-weapons related projects. These projects lead to commercial and economic benefits for both the NIS and the US IPP projects are funded in Russian, Ukraine, Kazakhstan and Belarus. This booklet offers an overview of the IPP program as well as a sampling of some of the projects which are currently underway.
Discrete Coherent State Path Integrals
Marchioro, Thomas L., II
1990-01-01
The quantum theory provides a fundamental understanding of the physical world; however, as the number of degrees of freedom rises, the information required to specify quantum wavefunctions grows geometrically. Because basis set expansions mirror this geometric growth, a strict practical limit on quantum mechanics as a numerical tool arises, specifically, three degrees of freedom or fewer. Recent progress has been made utilizing Feynman's Path Integral formalism to bypass this geometric growth and instead calculate time -dependent correlation functions directly. The solution of the Schrodinger equation is converted into a large dimensional (formally infinite) integration, which can then be attacked with Monte Carlo techniques. To date, work in this area has concentrated on developing sophisticated mathematical algorithms for evaluating the highly oscillatory integrands occurring in Feynman Path Integrals. In an alternative approach, this work demonstrates two formulations of quantum dynamics for which the number of mathematical operations does not scale geometrically. Both methods utilize the Coherent State basis of quantum mechanics. First, a localized coherent state basis set expansion and an approximate short time propagator are developed. Iterations of the short time propagator lead to the full quantum dynamics if the coherent state basis is sufficiently dense along the classical phase space path of the system. Second, the coherent state path integral is examined in detail. For a common class of Hamiltonians, H = p^2/2 + V( x) the path integral is reformulated from a phase space-like expression into one depending on (q,dot q). It is demonstrated that this new path integral expression contains localized damping terms which can serve as a statistical weight for Monte Carlo evaluation of the integral--a process which scales approximately linearly with the number of degrees of freedom. Corrections to the traditional coherent state path integral, inspired by a
Uncertainties in Nuclear Proliferation Modeling
Kim, Chul Min; Yim, Man-Sung; Park, Hyeon Seok [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)
2015-05-15
There have been various efforts in the research community to understand the determinants of nuclear proliferation and develop quantitative tools to predict nuclear proliferation events. Such systematic approaches have shown the possibility to provide warning for the international community to prevent nuclear proliferation activities. However, there are still large debates for the robustness of the actual effect of determinants and projection results. Some studies have shown that several factors can cause uncertainties in previous quantitative nuclear proliferation modeling works. This paper analyzes the uncertainties in the past approaches and suggests future works in the view of proliferation history, analysis methods, and variable selection. The research community still lacks the knowledge for the source of uncertainty in current models. Fundamental problems in modeling will remain even other advanced modeling method is developed. Before starting to develop fancy model based on the time dependent proliferation determinants' hypothesis, using graph theory, etc., it is important to analyze the uncertainty of current model to solve the fundamental problems of nuclear proliferation modeling. The uncertainty from different proliferation history coding is small. Serious problems are from limited analysis methods and correlation among the variables. Problems in regression analysis and survival analysis cause huge uncertainties when using the same dataset, which decreases the robustness of the result. Inaccurate variables for nuclear proliferation also increase the uncertainty. To overcome these problems, further quantitative research should focus on analyzing the knowledge suggested on the qualitative nuclear proliferation studies.
Proliferation: myth or reality?; La proliferation: mythe ou realite?
NONE
2005-07-01
This article analyzes the proliferation approach, its technical condition and political motivation, and the share between the myth (political deception, assumptions and extrapolations) and the reality of proliferation. Its appreciation is complicated by the irrational behaviour of some political actors and by the significant loss of the non-use taboo. The control of technologies is an important element for proliferation slowing down but an efficient and autonomous intelligence system remains indispensable. (J.S.)
An optimization approach for mapping and measuring the divergence and correspondence between paths.
Mueller, Shane T; Perelman, Brandon S; Veinott, Elizabeth S
2016-03-01
Many domains of empirical research produce or analyze spatial paths as a measure of behavior. Previously, approaches for measuring the similarity or deviation between two paths have either required timing information or have used ad hoc or manual coding schemes. In this paper, we describe an optimization approach for robustly measuring the area-based deviation between two paths we call ALCAMP (Algorithm for finding the Least-Cost Areal Mapping between Paths). ALCAMP measures the deviation between two paths and produces a mapping between corresponding points on the two paths. The method is robust to a number of aspects in real path data, such as crossovers, self-intersections, differences in path segmentation, and partial or incomplete paths. Unlike similar algorithms that produce distance metrics between trajectories (i.e., paths that include timing information), this algorithm uses only the order of observed path segments to determine the mapping. We describe the algorithm and show its results on a number of sample problems and data sets, and demonstrate its effectiveness for assessing human memory for paths. We also describe available software code written in the R statistical computing language that implements the algorithm to enable data analysis.
New sufficient conditions for Hamiltonian paths.
Rahman, M Sohel; Kaykobad, M; Firoz, Jesun Sahariar
2014-01-01
A Hamiltonian path in a graph is a path involving all the vertices of the graph. In this paper, we revisit the famous Hamiltonian path problem and present new sufficient conditions for the existence of a Hamiltonian path in a graph.
Population Monotonic Path Schemes for Simple Games
Ciftci, B.B.; Borm, P.E.M.; Hamers, H.J.M.
2006-01-01
A path scheme for a simple game is composed of a path, i.e., a sequence of coalitions that is formed during the coalition formation process and a scheme, i.e., a payoff vector for each coalition in the path.A path scheme is called population monotonic if a player's payoff does not decrease as the pa
Zuk, J.
1976-01-01
Improved gas-path seals are needed for better fuel economy, longer performance retention, and lower maintenance, particularly in advanced, high-performance gas turbine engines. Problems encountered in gas-path sealing are described, as well as new blade-tip sealing approaches for high-pressure compressors and turbines. These include a lubricant coating for conventional, porous-metal, rub-strip materials used in compressors. An improved hot-press metal alloy shows promise to increase the operating surface temperatures of high-pressure-turbine, blade-tip seals to 1450 K (2150 F). Three ceramic seal materials are also described that have the potential to allow much higher gas-path surface operating temperatures than are possible with metal systems.
Rainbow paths with prescribed ends
Alishahi, Meysam; Taherkhani, Ali; Thomassen, Carsten
2011-01-01
It was conjectured in [S. Akbari, F. Khaghanpoor, and S. Moazzeni. Colorful paths in vertex coloring of graphs. Preprint] that, if G is a connected graph distinct from C-7, then there is a chi(G)-coloring of G in which every vertex v is an element of V(G) is an initial vertex of a path P with chi......(G) vertices whose colors are different. In[S. Akbari, V. Liaghat, and A. Nikzad. Colorful paths in vertex coloring of graphs. Electron. J. Combin. 18(1):P17, 9pp, 2011] this was proved with left perpendicular chi(G)/2right perpendicular vertices instead of chi(G) vertices. We strengthen this to chi(G) - 1...
Innovative development path of ethnomedicines: the interpretation of the path.
Zhu, Zhaoyun; Fu, Dehuan; Gui, Yali; Cui, Tao; Wang, Jingkun; Wang, Ting; Yang, Zhizhong; Niu, Yanfei; She, Zhennan; Wang, Li
2017-03-01
One of the primary purposes of the innovative development of ethnomedicines is to use their excellent safety and significant efficacy to serve a broader population. To achieve this purpose, modern scientific and technological means should be referenced, and relevant national laws and regulations as well as technical guides should be strictly followed to develop standards and to perform systemic research in producing ethnomedicines. Finally, ethnomedicines, which are applied to a limited extent in ethnic areas, can be transformed into safe, effective, and quality-controllable medical products to relieve the pain of more patients. The innovative development path of ethnomedicines includes the following three primary stages: resource study, standardized development research, and industrialization of the achievements and efforts for internationalization. The implementation of this path is always guaranteed by the research and development platform and the talent team. This article is based on the accumulation of long-term practice and is combined with the relevant disciplines, laws and regulations, and technical guidance from the research and development of ethnomedicines. The intention is to perform an in-depth analysis and explanation of the major research thinking, methods, contents, and technical paths involved in all stages of the innovative development path of ethnomedicines to provide useful references for the development of proper ethnomedicine use.
Path Decomposition of Graphs with Given Path Length
Ming-qing Zhai; Chang-hong Lü
2006-01-01
A path decomposition of a graph G is a list of paths such that each edge appears in exactly one path in the list. G is said to admit a {Pl}-decomposition if G can be decomposed into some copies of Pl, where Pl is a path of length ι - 1. Similarly, G is said to admit a {Pl, Pκ}-decomposition if G can be decomposed into some copies of Pl or Pκ. An κ-cycle, denoted by Cκ, is a cycle with κ vertices. An odd tree is a tree of which all vertices have odd degree. In this paper, it is shown that a connected graph G admits a {P3, P4}-decomposition if and only if G is neither a 3-cycle nor an odd tree. This result includes the related result of Yan, Xu and Mutu. Moreover, two polynomial algorithms are given to find {P3}-decomposition and {P3, P4}-decomposition of graphs, respectively. Hence, {P3}-decomposition problem and {P3, P4}-decomposition problem of graphs are solved completely.
Blue light inhibits proliferation of melanoma cells
Becker, Anja; Distler, Elisabeth; Klapczynski, Anna; Arpino, Fabiola; Kuch, Natalia; Simon-Keller, Katja; Sticht, Carsten; van Abeelen, Frank A.; Gretz, Norbert; Oversluizen, Gerrit
2016-03-01
Photobiomodulation with blue light is used for several treatment paradigms such as neonatal jaundice, psoriasis and back pain. However, little is known about possible side effects concerning melanoma cells in the skin. The aim of this study was to assess the safety of blue LED irradiation with respect to proliferation of melanoma cells. For that purpose we used the human malignant melanoma cell line SK-MEL28. Cell proliferation was decreased in blue light irradiated cells where the effect size depended on light irradiation dosage. Furthermore, with a repeated irradiation of the melanoma cells on two consecutive days the effect could be intensified. Fluorescence-activated cell sorting with Annexin V and Propidium iodide labeling did not show a higher number of dead cells after blue light irradiation compared to non-irradiated cells. Gene expression analysis revealed down-regulated genes in pathways connected to anti-inflammatory response, like B cell signaling and phagosome. Most prominent pathways with up-regulation of genes were cytochrome P450, steroid hormone biosynthesis. Furthermore, even though cells showed a decrease in proliferation, genes connected to the cell cycle were up-regulated after 24h. This result is concordant with XTT test 48h after irradiation, where irradiated cells showed the same proliferation as the no light negative control. In summary, proliferation of melanoma cells can be decreased using blue light irradiation. Nevertheless, the gene expression analysis has to be further evaluated and more studies, such as in-vivo experiments, are warranted to further assess the safety of blue light treatment.
Spin Observables and Path Integrals
López, J A
2000-01-01
We discuss the formulation of spin observables associated to a non-relativistic spinning particles in terms of grassmanian differential operators. We use as configuration space variables for the pseudo-classical description of this system the positions $x$ and a Grassmanian vector quantum amplitudes as path integrals in this superspace. We compute the quantum action necessary for this description including an explicit expression for the boundary terms. Finally we shown how for simple examples, the path integral may be performed in the semi-classical approximation, leading to the correct quantum propagator.
Paths of algebraic hyperbolic curves
Ya-juan LI; Li-zheng LU; Guo-zhao WANG
2008-01-01
Cubic algebraic hyperbolic (AH) Bezier curves and AH spline curves are defined with a positive parameter α in the space spanned by {1, t, sinht, cosht}. Modifying the value of α yields a family of AH Bezier or spline curves with the family parameter α. For a fixed point on the original curve, it will move on a defined curve called "path of AH curve" (AH Bezier and AH spline curves) when α changes. We describe the geometric effects of the paths and give a method to specify a curve passing through a given point.
Strings, paths, and standard tableaux
Dasmahapatra, S
1996-01-01
For the vacuum sectors of regime-III ABF models, we observe that two sets of combinatorial objects: the strings which parametrize the row-to-row transfer matrix eigenvectors, and the paths which parametrize the corner transfer matrix eigenvectors, can both be expressed in terms of the same set of standard tableaux. Furthermore, the momenta of the strings, the energies of the paths, and the charges of the tableaux are such that there is a weight-preserving bijection between the two sets of eigenvectors, wherein the tableaux play an interpolating role. This bijection is so natural, that we conjecture that it exists in general.
On the path to differentiation
Martinsen, Dorte Sindbjerg; Uygur, Ayca
2014-01-01
by examining the ‘path to differentiation’ within EU working time regulation as it has unfolded over time. It identifies the ‘opt-out’ as a means of differentiation adopted to overcome policy deadlocks within collective decision-making, albeit one with unforeseen consequences. In particular, the contribution...
Career Paths in Environmental Sciences
Career paths, current and future, in the environmental sciences will be discussed, based on experiences and observations during the author's 40 + years in the field. An emphasis will be placed on the need for integrated, transdisciplinary systems thinking approaches toward achie...
无
2001-01-01
On the path space over a compact Riemannian manifold, the global existence and the global uniqueness of the quasi-invariant geodesic flows with respect to a negative Markov connection are obtained in this paper. The results answer affirmatively a left problem of Li.
Path integral for inflationary perturbations
Prokopec, T.; Rigopoulos, G.
2010-01-01
The quantum theory of cosmological perturbations in single-field inflation is formulated in terms of a path integral. Starting from a canonical formulation, we show how the free propagators can be obtained from the well-known gauge-invariant quadratic action for scalar and tensor perturbations, and
Methodologies for tracking learning paths
Frølunde, Lisbeth; Gilje, Øystein; Lindstrand, Fredrik
2009-01-01
The article concerns the design of a collaborative research project (2008-09) entitled Making a Filmmaker, which examines how young Scandinavian filmmakers create their own learn- ing paths in formal and/or informal contexts. Our interest is how learning experiences and contexts motivate the young...
Determinants of weighted path matrices
Talaska, Kelli
2012-01-01
We find rational expressions for all minors of the weighted path matrix of a directed graph, generalizing the classical Lindstrom/Gessel-Viennot result for acyclic directed graphs. The formulas are given in terms of certain flows in the graph.
M. J. Wooster
2011-02-01
Full Text Available Biomass burning emissions factors are vital to quantifying trace gases releases from vegetation fires. Here we evaluate emissions factors for a series of savannah fires in Kruger National Park (KNP, South Africa using ground-based open path Fourier transform infrared (FTIR spectroscopy and an infrared lamp separated by 150–250 m distance. Molecular abundances along the extended open path are retrieved using a spectral forward model coupled to a non-linear least squares fitting approach. We demonstrate derivation of trace gas column amounts for horizontal paths transecting the width of the advected plume, and find, for example, that CO mixing ratio changes of ~0.001 μmol mol^{−1} (~10 ppbv can be detected across the relatively long optical paths used here. We focus analysis on five key compounds whose production is preferential during the pyrolysis (CH_{2}O, flaming (CO_{2} and smoldering (CO, CH_{4}, NH_{3} fire phases. We demonstrate that well constrained emissions ratios for these gases to both CO_{2} and CO can be derived for the backfire, headfire and residual smouldering combustion stages of these savannah fires, from which stage-specific emission factors can then be calculated. Headfires and backfires in general show similar emission ratios and emission factors, but those of the residual smouldering combustion stage can differ substantially (e.g., ER_{CH4/CO2} up to ~7 times higher than for the flaming stages. The timing of each fire stage was identified via airborne optical and thermal IR imagery and ground-observer reports, with the airborne IR imagery also used to derive estimates of fire radiative energy, thus allowing the relative amount of fuel burned in each stage to be calculated and the "fire averaged" emission ratios and emission factors to be determined. The derived "fire averaged" emission ratios are dominated by the headfire contribution, since
Optimal paths as correlated random walks
Perlsman, E.; Havlin, S.
2006-01-01
A numerical study of optimal paths in the directed polymer model shows that the paths are similar to correlated random walks. It is shown that when a directed optimal path of length t is divided into 3 segments whose length is t/3, the correlation between the transversal movements along the first and last path segments is independent of the path length t. It is also shown that the transversal correlations along optimal paths decrease as the paths approach their endpoints. The numerical results obtained for optimal paths in 1+4 dimensions are qualitatively similar to those obtained for optimal paths in lower dimensions, and the data supplies a strong numerical indication that 1+4 is not the upper critical dimension of this model, and of the associated KPZ equation.
Castilla, Carmen; McDonough, Patrick; Tumer, Gizem; Lambert, Peter C; Lambert, W Clark
2012-01-01
The degree of cell proliferation in a tumor is often associated with metastatic risk and mortality. Proliferating cell nuclear antigen (PCNA) and Ki-67 are proliferation markers that can be used to assess malignant potential in cutaneous lesions and pathological cell proliferation in psoriasis. These markers are elevated during periods of cell proliferation; however, they are also upregulated following UV irradiation. This upregulation may be problematic, as many skin lesions are subject to sun exposure in an everyday setting.
Janssen, José
2008-01-01
Jansen, J. (2008). Facilitating Description and Selection of Learning Paths: the learning path specification put to the test. Presentation at the Otec Colloquium. April, 2008, Heerlen, The Netherlands.
Janssen, José
2008-01-01
Jansen, J. (2008). Facilitating Description and Selection of Learning Paths: the learning path specification put to the test. Presentation at the Otec Colloquium. April, 2008, Heerlen, The Netherlands.
Adolescent Support Seeking as a Path to Adult Functional Independence
Szwedo, David E.; Hessel, Elenda T.; Loeb, Emily L.; Hafen, Christopher A.; Allen, Joseph P.
2017-01-01
The potential importance of depending on others during adolescence to establish independence in young adulthood was examined across adolescence to emerging adulthood. Participants included 184 teens (46% male; 42% non-White), their mothers, best friends, and romantic partners, assessed at ages 13-14, 18, 21-22, and 25. Path analyses showed that…
Shortest Paths With Side Sensors
Salaris, Paolo; Bicchi, Antonio
2011-01-01
We present a complete characterization of shortest paths to a goal position for a vehicle with unicycle kinematics and a limited range sensor, constantly keeping a given landmark in sight. Previous work on this subject studied the optimal paths in case of a frontal, symmetrically limited Field--Of--View (FOV). In this paper we provide a generalization to the case of arbitrary FOVs, including the case that the direction of motion is not an axis of symmetry for the FOV, and even that it is not contained in the FOV. The provided solution is of particular relevance to applications using side-scanning, such as e.g. in underwater sonar-based surveying and navigation.
Stochastic control with rough paths
Diehl, Joscha [University of California San Diego (United States); Friz, Peter K., E-mail: friz@math.tu-berlin.de [TU & WIAS Berlin (Germany); Gassiat, Paul [CEREMADE, Université Paris-Dauphine, PSL Research University (France)
2017-04-15
We study a class of controlled differential equations driven by rough paths (or rough path realizations of Brownian motion) in the sense of Lyons. It is shown that the value function satisfies a HJB type equation; we also establish a form of the Pontryagin maximum principle. Deterministic problems of this type arise in the duality theory for controlled diffusion processes and typically involve anticipating stochastic analysis. We make the link to old work of Davis and Burstein (Stoch Stoch Rep 40:203–256, 1992) and then prove a continuous-time generalization of Roger’s duality formula [SIAM J Control Optim 46:1116–1132, 2007]. The generic case of controlled volatility is seen to give trivial duality bounds, and explains the focus in Burstein–Davis’ (and this) work on controlled drift. Our study of controlled rough differential equations also relates to work of Mazliak and Nourdin (Stoch Dyn 08:23, 2008).
Levy Flights over Quantum Paths
Laskin, N
2005-01-01
An impact of integration over the paths of the Levy flights on the quantum mechanical kernel has been studied. Analytical expression for a free particle kernel has been obtained in terms of the Fox H-function. A new equation for the kernel of a partical in the box has been found. New general results include the well known quantum formulae for a free particle kernel and particle in box kernel.
CERN. Geneva
2017-01-01
Join the path of code linting and discover how it can help you reach higher levels of programming enlightenment. Today we will cover how to embrace code linters to offload cognitive strain on preserving style standards in your code base as well as avoiding error-prone constructs. Additionally, I will show you the journey ahead for integrating several code linters in the programming tools your already use with very little effort.
AFM's path to atomic resolution
2005-01-01
We review progress in improving the spatial resolution of atomic force microscopy (AFM) under vacuum. After an introduction to the basic imaging principle and a conceptual comparison to scanning tunneling microscopy (STM), we outline the main challenges of AFM as well as the solutions that have evolved in the first 20 years of its existence. Some crucial steps along AFM's path toward higher resolution are discussed, followed by an outlook on current and future applications.
Path planning under spatial uncertainty.
Wiener, Jan M; Lafon, Matthieu; Berthoz, Alain
2008-04-01
In this article, we present experiments studying path planning under spatial uncertainties. In the main experiment, the participants' task was to navigate the shortest possible path to find an object hidden in one of four places and to bring it to the final destination. The probability of finding the object (probability matrix) was different for each of the four places and varied between conditions. Givensuch uncertainties about the object's location, planning a single path is not sufficient. Participants had to generate multiple consecutive plans (metaplans)--for example: If the object is found in A, proceed to the destination; if the object is not found, proceed to B; and so on. The optimal solution depends on the specific probability matrix. In each condition, participants learned a different probability matrix and were then asked to report the optimal metaplan. Results demonstrate effective integration of the probabilistic information about the object's location during planning. We present a hierarchical planning scheme that could account for participants' behavior, as well as for systematic errors and differences between conditions.
Spreading paths in partially observed social networks
Onnela, Jukka-Pekka
2011-01-01
Understanding how far information, behaviors, or pathogens spread in social networks is an important problem, having implications for both predicting the size of epidemics, as well as for planning effective interventions. There are, however, two main challenges for inferring spreading path lengths in real-world networks. One is the practical difficulty of observing a dynamic process on a network, and the other is the typical constraint of only partially observing a network. Using a static, structurally realistic social network as a platform for simulations, we juxtapose three distinct paths: (1) the stochastic path taken by a simulated spreading process from source to target; (2) the topologically shortest path in the fully observed network, and hence the single most likely stochastic path, between the two nodes; and (3) the topologically shortest path in a partially observed network. In a sampled network, how closely does the partially observed shortest path (3) emulate the unobserved spreading path (1)? Alt...
Time optimal paths for high speed maneuvering
Reister, D.B.; Lenhart, S.M.
1993-01-01
Recent theoretical results have completely solved the problem of determining the minimum length path for a vehicle with a minimum turning radius moving from an initial configuration to a final configuration. Time optimal paths for a constant speed vehicle are a subset of the minimum length paths. This paper uses the Pontryagin maximum principle to find time optimal paths for a constant speed vehicle. The time optimal paths consist of sequences of axes of circles and straight lines. The maximum principle introduces concepts (dual variables, bang-bang solutions, singular solutions, and transversality conditions) that provide important insight into the nature of the time optimal paths. We explore the properties of the optimal paths and present some experimental results for a mobile robot following an optimal path.
Path-based Queries on Trajectory Data
Krogh, Benjamin Bjerre; Pelekis, Nikos; Theodoridis, Yannis
2014-01-01
a specific path by only retrieving data from the first and last edge in the path. To correctly answer strict path queries existing network-constrained trajectory indexes must retrieve data from all edges in the path. An extensive performance study of NETTRA using a very large real-world trajectory data set....... To efficiently support strict path queries, we present a novel NETwork-constrained TRAjectory index (NETTRA). This index enables very efficient retrieval of trajectories that follow a specific path, i.e., strict path queries. NETTRA uses a new path encoding scheme that can determine if a trajectory follows......, consisting of 1.7 million trajectories (941 million GPS records) and a road network with 1.3 million edges, shows a speed-up of two orders of magnitude compared to state-of-the-art trajectory indexes....
Multiresolution Path Planning for Mobile Robots,
1985-05-01
8217U’ MULTIRESOLUTION PATH PLANNING * . FOR MOBILE ROBOTS I Subbarao Kambhampati * -- Larry S. Davis Computer Vision Laboratory * Center for Automation...COUWEPARK MARVUM EP Vo Is- .. . .. CAR-TR-127 DAAK70-83-K--0018 CS-TR-1507 MAY 1085 MULTIRESOLUTION PATH PLANNING FOR MOBILE ROBOTS Subbarao Kambhampati...planning is central to mobile * robot applications. Path planning for mobile robots is in many ways different * from the more familiar case of path
Multiple Paths to Encephalization and Technical Civilizations
Schwartzman, David; Middendorf, George
2011-12-01
We propose consideration of at least two possible evolutionary paths for the emergence of intelligent life with the potential for technical civilization. The first is the path via encephalization of homeothermic animals; the second is the path to swarm intelligence of so-called superorganisms, in particular the social insects. The path to each appears to be facilitated by environmental change: homeothermic animals by decreased climatic temperature and for swarm intelligence by increased oxygen levels.
Path-Based Supports for Hypergraphs
Brandes, Ulrik; Cornelsen, Sabine; Pampel, Barbara; Sallaberry, Arnaud
A path-based support of a hypergraph H is a graph with the same vertex set as H in which each hyperedge induces a Hamiltonian subgraph. While it is NP-complete to compute a path-based support with the minimum number of edges or to decide whether there is a planar path-based support, we show that a path-based tree support can be computed in polynomial time if it exists.
Fundamental changes to EPA's research enterprise: the path forward.
Anastas, Paul T
2012-01-17
Environmental protection in the United States has reached a critical juncture. It has become clear that to address the complex and interrelated environmental challenges we face, we must augment our traditional approaches. The scientific community must build upon its deep understanding of risk assessment, risk management, and reductionism with tools, technologies, insights and approaches to pursue sustainability. The U.S. Environmental Protection Agency (EPA) has recognized this need for systemic change by implementing a new research paradigm called "The Path Forward." This paper outlines the principles of the Path Forward and the actions taken since 2010 to align EPA's research efforts with the goal of sustainability.
Da-lei ZHANG; Kai-ming WANG; Cai-qiao ZHANG
2009-01-01
The effect of ginsenosides on proliferation of type A spermatogonia was investigated in 7-day-old mice.Spermatogonia were characterized by c-kit expression and cell proliferation was assessed by immunocytochemical demonstration of proliferating cell nuclear antigen (PCNA).After 72-h culture,Sertoli cells formed a confluent monolayer to which numerous spermatogonial colonies attached.Spermatogonia were positive for c-kit staining and showed high proliferating activity by PCNA expression.Ginsenosides (1.0～10 μg/ml) significantly stimulated proliferation of spermatogonia.Activation of protein kinase C (PKC) elicited proliferation of spermatogonia at 10-8 to 107 mol/L and the PKC inhibitor H7 inhibited this effect.Likewise,ginsenosides-stimulated spermatogonial proliferation was suppressed by combined treatment of H7.These results indicate that the proliferating effect ofginsenosides on mouse type A spermatogonia might be mediated by a mechanism involving the PKC signal transduction pathway.
Partial Path Column Generation for the ESPPRC
Jepsen, Mads Kehlet; Petersen, Bjørn
This talk introduces a decomposition of the Elementary Shortest Path Problem with Resource Constraints(ESPPRC), where the path is combined by smaller sub paths. We show computational result by comparing different approaches for the decomposition and compare the best of these with existing...
Multi-level Indoor Path Planning Method
Xiong, Q.; Zhu, Q.; Zlatanova, S.; Du, Z.; Zhang, Y.; Zeng, L.
2015-01-01
Indoor navigation is increasingly widespread in complex indoor environments, and indoor path planning is the most important part of indoor navigation. Path planning generally refers to finding the most suitable path connecting two locations, while avoiding collision with obstacles. However, it is a
A SCALED CENTRAL PATH FOR LINEAR PROGRAMMING
Ya-xiang Yuan
2001-01-01
Interior point methods are very efficient methods for solving large scale linear programming problems. The central path plays a very important role in interior point methods. In this paper we propose a new central path, which scales the variables. Thus it has the advantage of forcing the path to have roughly the same distance from each active constraint boundary near the solution.
Luckow, Kasper Søe; Păsăreanu, Corina
2014-01-01
We describe Symbolic PathFinder v7 in terms of its updated design addressing the changes of Java PathFinder v7 and of its new optimization when computing path conditions. Furthermore, we describe the Symbolic Execution Tree Extension; a newly added feature that allows for outputting the symbolic ...
Classical and quantum dynamics from classical paths to path integrals
Dittrich, Walter
2016-01-01
Graduate students who want to become familiar with advanced computational strategies in classical and quantum dynamics will find here both the fundamentals of a standard course and a detailed treatment of the time-dependent oscillator, Chern-Simons mechanics, the Maslov anomaly and the Berry phase, to name a few. Well-chosen and detailed examples illustrate the perturbation theory, canonical transformations, the action principle and demonstrate the usage of path integrals. This new edition has been revised and enlarged with chapters on quantum electrodynamics, high energy physics, Green’s functions and strong interaction.
Cell proliferation in gastrointestinal mucosa.
Wong, W M; Wright, N A
1999-01-01
Gastrointestinal cell proliferation plays an important role in the maintenance of the integrity of the gastrointestinal system. The study of gastrointestinal proliferation kinetics allows a better understanding of the complexity of the system, and also has important implications for the study of gastrointestinal carcinogenesis. Gastrointestinal stem cells are shown to be pluripotential and to give rise to all cell lineages in the epithelium. Carcinogenesis in the colon occurs through sequenti...
Xia Bai; Jun-Ping Wang; Lan Ming; Ya-Jie Xu; Xia Sun
2016-01-01
Objective: To investigate the effect of the nursing path on postoperative complications after endoscopic submucosal dissection (ESD). Method: Patients' nursing paths for ESD were established based on a systematic analysis of relevant literature, previous clinical procedures and consultation with chief physicians from a gastroenterology department. Forty patients were divided into the observation or control group and were assigned to follow the nursing path or the conventional path after an ESD, respectively. Next, the incidence of postoperative complications of these two groups was measured, primarily assessing the occurrences of bleeding, perforation, infection, and anxiety. Results: The incidence of complications after ESD in the observation group was remarkably lower than that of the control group (P Conclusion: The nursing path for ESD has a positive role in reducing certain frequent complications that occur after ESD, particularly infection and anxiety;in addition, the nursing path optimizes nursing care in patients with gastrointestinal stromal tumor.
Seismic refraction analysis: the path forward
Haines, Seth S.; Zelt, Colin; Doll, William
2012-01-01
Seismic Refraction Methods: Unleashing the Potential and Understanding the Limitations; Tucson, Arizona, 29 March 2012 A workshop focused on seismic refraction methods took place on 29 May 2012, associated with the 2012 Symposium on the Application of Geophysics to Engineering and Environmental Problems. This workshop was convened to assess the current state of the science and discuss paths forward, with a primary focus on near-surface problems but with an eye on all applications. The agenda included talks on these topics from a number of experts interspersed with discussion and a dedicated discussion period to finish the day. Discussion proved lively at times, and workshop participants delved into many topics central to seismic refraction work.
Small Aircraft RF Interference Path Loss
Nguyen, Truong X.; Koppen, Sandra V.; Ely, Jay J.; Szatkowski, George N.; Mielnik, John J.; Salud, Maria Theresa P.
2007-01-01
Interference to aircraft radio receivers is an increasing concern as more portable electronic devices are allowed onboard. Interference signals are attenuated as they propagate from inside the cabin to aircraft radio antennas mounted on the outside of the aircraft. The attenuation level is referred to as the interference path loss (IPL) value. Significant published IPL data exists for transport and regional category airplanes. This report fills a void by providing data for small business/corporate and general aviation aircraft. In this effort, IPL measurements are performed on ten small aircraft of different designs and manufacturers. Multiple radio systems are addressed. Along with the typical worst-case coupling values, statistical distributions are also reported that could lead to better interference risk assessment.
Small Aircraft RF Interference Path Loss Measurements
Nguyen, Truong X.; Koppen, Sandra V.; Ely, Jay J.; Szatkowski, George N.; Mielnik, John J.; Salud, Maria Theresa P.
2007-01-01
Interference to aircraft radio receivers is an increasing concern as more portable electronic devices are allowed onboard. Interference signals are attenuated as they propagate from inside the cabin to aircraft radio antennas mounted on the outside of the aircraft. The attenuation level is referred to as the interference path loss (IPL) value. Significant published IPL data exists for transport and regional category airplanes. This report fills a void by providing data for small business/corporate and general aviation aircraft. In this effort, IPL measurements are performed on ten small aircraft of different designs and manufacturers. Multiple radio systems are addressed. Along with the typical worst-case coupling values, statistical distributions are also reported that could lead to more meaningful interference risk assessment.
Solar technologies and the soft path: an empirical examination
Lodwick, D.G.
1987-01-01
A US national probability sample of 2023 traditional energy users and a purposive sample of 3809 solar energy technology owners are compared to assess whether those who owned solar energy technologies in 1980 have more soft path preferences (SPP) (e.g., attitudes and behaviors compatible with soft energy path developments) than do those who did not own such technologies. It is suggested that SPP is a necessary but not sufficient condition for the social structural transformation of society to the soft energy path proposed by Amory Lovins. A soft-path preferences scale is developed. The scale values for solar and nonsolar homeowners, for active and passive solar technology owners, and for those owing the technologies for four different time periods are compared. The nonsolar homeowners, passive technology owners, and those who owned the technologies from one to five years have the highest SPP scores. The greatest differences were found in the dimension of natural resources conservation. Partial least squares structural equation modeling is used to examine an extension and specification of Lovins' theory of soft-energy-path development. A model is created which focuses on the process of SPP development. Energy vulnerability needs, contextual resources, type of solar technologies, technological problems, and evaluation are the independent variables of the model.
Relations between Coherence and Path Information.
Bagan, Emilio; Bergou, János A; Cottrell, Seth S; Hillery, Mark
2016-04-22
We find two relations between coherence and path information in a multipath interferometer. The first builds on earlier results for the two-path interferometer, which used minimum-error state discrimination between detector states to provide the path information. For visibility, which was used in the two-path case, we substitute a recently defined l_{1} measure of quantum coherence. The second is an entropic relation in which the path information is characterized by the mutual information between the detector states and the outcome of the measurement performed on them, and the coherence measure is one based on relative entropy.
Link prediction based on path entropy
Xu, Zhongqi; Yang, Jian
2015-01-01
Information theory has been taken as a prospective tool for quantifying the complexity of complex networks. In this paper, we first study the information entropy or uncertainty of a path using the information theory. Then we apply the path entropy to the link prediction problem in real-world networks. Specifically, we propose a new similarity index, namely Path Entropy (PE) index, which considers the information entropies of shortest paths between node pairs with penalization to long paths. Empirical experiments demonstrate that PE index outperforms the mainstream link predictors.
Strategic Path Reliability in Information Networks
Kannan, Rajgopal; Sarangi, Sudipta; Iyengar, Sundaraja Sitharama
2002-01-01
We consider a model of an information network where nodes can fail and transmission of information is costly. The formation of paths in such networks is modeled as the Nash equilibrium of an N player routing game. The task of obtaining this equilibrium is shown to be NP-Hard. We derive analytical results to identify conditions under which the equilibrium path is congruent to well known paths such as the most reliable or cheapest neighbor path. The issue of characterizing off-equilibrium paths...
Two Generations of Path Dependence in Economics?
Madsen, Mogens Ove
2010-01-01
Even if there is no fully articulated and generally accepted theory of Path Dependence it has eagerly been taken up across a wide range of social sciences – primarily coming from economics. Path Dependence is most of all a metaphor that offers reason to believe, that some political, social...... or economic processes have multiple possible paths of outcomes, rather than a unique path of equilibria. The selection among outcomes may depend on contingent choices or events – outcomes of path-dependent processes require a very relevant study – a perception of history....
Evaluation of guidewire path reproducibility.
Schafer, Sebastian; Hoffmann, Kenneth R; Noël, Peter B; Ionita, Ciprian N; Dmochowski, Jacek
2008-05-01
The number of minimally invasive vascular interventions is increasing. In these interventions, a variety of devices are directed to and placed at the site of intervention. The device used in almost all of these interventions is the guidewire, acting as a monorail for all devices which are delivered to the intervention site. However, even with the guidewire in place, clinicians still experience difficulties during the interventions. As a first step toward understanding these difficulties and facilitating guidewire and device guidance, we have investigated the reproducibility of the final paths of the guidewire in vessel phantom models on different factors: user, materials and geometry. Three vessel phantoms (vessel diameters approximately 4 mm) were constructed having tortuousity similar to the internal carotid artery from silicon tubing and encased in Sylgard elastomer. Several trained users repeatedly passed two guidewires of different flexibility through the phantoms under pulsatile flow conditions. After the guidewire had been placed, rotational c-arm image sequences were acquired (9 in. II mode, 0.185 mm pixel size), and the phantom and guidewire were reconstructed (512(3), 0.288 mm voxel size). The reconstructed volumes were aligned. The centerlines of the guidewire and the phantom vessel were then determined using region-growing techniques. Guidewire paths appear similar across users but not across materials. The average root mean square difference of the repeated placement was 0.17 +/- 0.02 mm (plastic-coated guidewire), 0.73 +/- 0.55 mm (steel guidewire) and 1.15 +/- 0.65 mm (steel versus plastic-coated). For a given guidewire, these results indicate that the guidewire path is relatively reproducible in shape and position.
Attention trees and semantic paths
Giusti, Christian; Pieroni, Goffredo G.; Pieroni, Laura
2007-02-01
In the last few decades several techniques for image content extraction, often based on segmentation, have been proposed. It has been suggested that under the assumption of very general image content, segmentation becomes unstable and classification becomes unreliable. According to recent psychological theories, certain image regions attract the attention of human observers more than others and, generally, the image main meaning appears concentrated in those regions. Initially, regions attracting our attention are perceived as a whole and hypotheses on their content are formulated; successively the components of those regions are carefully analyzed and a more precise interpretation is reached. It is interesting to observe that an image decomposition process performed according to these psychological visual attention theories might present advantages with respect to a traditional segmentation approach. In this paper we propose an automatic procedure generating image decomposition based on the detection of visual attention regions. A new clustering algorithm taking advantage of the Delaunay- Voronoi diagrams for achieving the decomposition target is proposed. By applying that algorithm recursively, starting from the whole image, a transformation of the image into a tree of related meaningful regions is obtained (Attention Tree). Successively, a semantic interpretation of the leaf nodes is carried out by using a structure of Neural Networks (Neural Tree) assisted by a knowledge base (Ontology Net). Starting from leaf nodes, paths toward the root node across the Attention Tree are attempted. The task of the path consists in relating the semantics of each child-parent node pair and, consequently, in merging the corresponding image regions. The relationship detected in this way between two tree nodes generates, as a result, the extension of the interpreted image area through each step of the path. The construction of several Attention Trees has been performed and partial
Communication path for extreme environments
Jorgensen, Charles C. (Inventor); Betts, Bradley J. (Inventor)
2010-01-01
Methods and systems for using one or more radio frequency identification devices (RFIDs), or other suitable signal transmitters and/or receivers, to provide a sensor information communication path, to provide location and/or spatial orientation information for an emergency service worker (ESW), to provide an ESW escape route, to indicate a direction from an ESW to an ES appliance, to provide updated information on a region or structure that presents an extreme environment (fire, hazardous fluid leak, underwater, nuclear, etc.) in which an ESW works, and to provide accumulated thermal load or thermal breakdown information on one or more locations in the region.
Uncommon paths in quantum physics
Kazakov, Konstantin V
2014-01-01
Quantum mechanics is one of the most fascinating, and at the same time most controversial, branches of contemporary science. Disputes have accompanied this science since its birth and have not ceased to this day. Uncommon Paths in Quantum Physics allows the reader to contemplate deeply some ideas and methods that are seldom met in the contemporary literature. Instead of widespread recipes of mathematical physics, based on the solutions of integro-differential equations, the book follows logical and partly intuitional derivations of non-commutative algebra. Readers can directly penetrate the
Gibbs Ensembles of Nonintersecting Paths
Borodin, Alexei
2008-01-01
We consider a family of determinantal random point processes on the two-dimensional lattice and prove that members of our family can be interpreted as a kind of Gibbs ensembles of nonintersecting paths. Examples include probability measures on lozenge and domino tilings of the plane, some of which are non-translation-invariant. The correlation kernels of our processes can be viewed as extensions of the discrete sine kernel, and we show that the Gibbs property is a consequence of simple linear relations satisfied by these kernels. The processes depend on infinitely many parameters, which are closely related to parametrization of totally positive Toeplitz matrices.
On the path to differentiation
Martinsen, Dorte Sindbjerg; Uygur, Ayca
2014-01-01
by examining the ‘path to differentiation’ within EU working time regulation as it has unfolded over time. It identifies the ‘opt-out’ as a means of differentiation adopted to overcome policy deadlocks within collective decision-making, albeit one with unforeseen consequences. In particular, the contribution...... investigates the causes and effects of differentiation by examining (1) its origin, (2) the ‘logic of variation’ or ‘opt-out spiral’ that spurs differentiation and (3) the implications of differentiation over time. We conclude that differentiation has dynamic and broad consequences that are likely to produce...
Path of Chinese institutional modernization
Sahoo, Ganeswar
2009-01-01
We see the progress today that China has developed a treasure of modernity in terms of its World figure both in economic development and its strong military power with countless path of ups and downs in the past. We are more concerned with the historical study of its institutional modernization than a mere philosophical debate over its development and can discuss its various levels of struggle for ‘Substitute Modernity’2 since mid-19th century(the two opium wars) to till date.
Paths and cycles of hypergraphs
王建方; Tony; T.Lee
1999-01-01
Hypergraphs are the most general structures in discrete mathematics. Acyclic hypergraphs have been proved very useful in relational databases. New systems of axioms for paths, connectivity and cycles of hypergraphs are constructed. The systems suit the structure properties of relational databases. The concepts of pseudo cycles and essential cycles of hypergraphs are introduced. They are relative to each other. Whether a family of cycles of a hypergraph is dependent or independent is defined. An enumeration formula for the maximum number of independent essential cycles of a hypergraph is given.
Physarum Can Compute Shortest Paths
Bonifaci, Vincenzo; Varma, Girish
2011-01-01
A mathematical model has been proposed by biologists to describe the feedback mechanism used by the Physarum Polycephalum slime mold to adapt its tubular channels while foraging two food sources $s_0$ and $s_1$. We give a proof of the fact that, under this model, the mass of the mold will eventually converge to the shortest $s_0$-$s_1$ path of the network that the mold lies on, independently of the structure of the network or of the initial mass distribution. This matches the experimental observations by the biologists and can be seen as an example of a "natural algorithm", that is, an algorithm developed by evolution over millions of years.
Deterministic Circular Self Test Path
WEN Ke; HU Yu; LI Xiaowei
2007-01-01
Circular self test path (CSTP) is an attractive technique for testing digital integrated circuits(IC) in the nanometer era, because it can easily provide at-speed test with small test data volume and short test application time. However, CSTP cannot reliably attain high fault coverage because of difficulty of testing random-pattern-resistant faults. This paper presents a deterministic CSTP (DCSTP) structure that consists of a DCSTP chain and jumping logic, to attain high fault coverage with low area overhead. Experimental results on ISCAS'89 benchmarks show that 100% fault coverage can be obtained with low area overhead and CPU time, especially for large circuits.
The Shortest Path with Intelligent Algorithm
Surachai Panich
2010-01-01
Full Text Available Problem statement: Path planning algorithms need to be developed and implemented in a suitable manner to give better understanding about the intelligent system and also stimulates technological supply to enormous demands in an intelligent vehicle industry. Approach: This study concerned with intelligent path planning using A* search algorithm. Results: This study introduced intelligent path planning with A* search algorithm, which use to generate the most efficient path to goal. The algorithm was tested on simulator. Conclusion: This study is an implementation of a path planning for an intelligent path planning. The implementations are tested and verified with the simulation software. The path planning algorithms were selected for the implementation and to verify them.
Longest-path attacks on complex networks
Pu, Cunlai
2014-01-01
We investigate the longest-path attacks on complex networks. Specifically, we remove approximately the longest simple path from a network iteratively until there are no paths left in the network. We propose two algorithms, the random augmenting approach (RPA) and the Hamilton-path based approach (HPA), for finding the approximately longest simple path in a network. Results demonstrate that steps of longest-path attacks increase with network density linearly for random networks, while exponentially increasing for scale-free networks. The more homogeneous the degree distribution is, the more fragile the network, which is totally different from the previous results of node or edge attacks. HPA is generally more efficient than RPA in the longest-path attacks of complex networks. These findings further help us understand the vulnerability of complex systems, better protect complex systems, and design more tolerant complex systems.
The Path to Deep Nuclear Reductions. Dealing with American Conventional Superiority
Gormley, D.M.
2009-07-01
The transformation of the U.S. conventional capabilities has begun to have a substantial and important impact on counter-force strike missions particularly as they affect counter-proliferation requirements. So too have improvements in ballistic missile defense programs, which are also critically central to U.S. counter-proliferation objectives. These improved conventional capabilities come at a time when thinking about the prospects of eventually achieving a nuclear disarmed world has never been so promising. Yet, the path toward achieving that goal, or making substantial progress towards it, is fraught with pitfalls, including domestic political, foreign, and military ones. Two of the most important impediments to deep reductions in U.S. and Russian nuclear arsenals - no less a nuclear disarmed world - are perceived U.S. advantages in conventional counter-force strike capabilities working in combination with even imperfect but growing missile defense systems. The Barack Obama administration has already toned down the George W. Bush administration's rhetoric surrounding many of these new capabilities. Nevertheless, it is likely to affirm that it is a worthy goal to pursue a more conventionally oriented denial strategy as America further weans itself from its reliance on nuclear weapons. The challenge is to do so in the context of a more multilateral or collective security environment in which transparency plays the role it once did during the Cold War as a necessary adjunct to arms control agreements. Considerable thought has already been devoted to assessing many of the challenges along the way to a nuclear-free world, including verifying arsenals when they reach very low levels, more effective management of the civilian nuclear programs that remain, enforcement procedures, and what, if anything, might be needed to deal with latent capacities to produce nuclear weapons.1 But far less thought has been expended on why Russia - whose cooperation is absolutely
Classical and quantum dynamics from classical paths to path integrals
Dittrich, Walter
2017-01-01
Graduate students who wish to become familiar with advanced computational strategies in classical and quantum dynamics will find in this book both the fundamentals of a standard course and a detailed treatment of the time-dependent oscillator, Chern-Simons mechanics, the Maslov anomaly and the Berry phase, to name just a few topics. Well-chosen and detailed examples illustrate perturbation theory, canonical transformations and the action principle, and demonstrate the usage of path integrals. The fifth edition has been revised and enlarged to include chapters on quantum electrodynamics, in particular, Schwinger’s proper time method and the treatment of classical and quantum mechanics with Lie brackets and pseudocanonical transformations. It is shown that operator quantum electrodynamics can be equivalently described with c-numbers, as demonstrated by calculating the propagation function for an electron in a prescribed classical electromagnetic field.
Integrated assignment and path planning
Murphey, Robert A.
2005-11-01
A surge of interest in unmanned systems has exposed many new and challenging research problems across many fields of engineering and mathematics. These systems have the potential of transforming our society by replacing dangerous and dirty jobs with networks of moving machines. This vision is fundamentally separate from the modern view of robotics in that sophisticated behavior is realizable not by increasing individual vehicle complexity, but instead through collaborative teaming that relies on collective perception, abstraction, decision making, and manipulation. Obvious examples where collective robotics will make an impact include planetary exploration, space structure assembly, remote and undersea mining, hazardous material handling and clean-up, and search and rescue. Nonetheless, the phenomenon driving this technology trend is the increasing reliance of the US military on unmanned vehicles, specifically, aircraft. Only a few years ago, following years of resistance to the use of unmanned systems, the military and civilian leadership in the United States reversed itself and have recently demonstrated surprisingly broad acceptance of increasingly pervasive use of unmanned platforms in defense surveillance, and even attack. However, as rapidly as unmanned systems have gained acceptance, the defense research community has discovered the technical pitfalls that lie ahead, especially for operating collective groups of unmanned platforms. A great deal of talent and energy has been devoted to solving these technical problems, which tend to fall into two categories: resource allocation of vehicles to objectives, and path planning of vehicle trajectories. An extensive amount of research has been conducted in each direction, yet, surprisingly, very little work has considered the integrated problem of assignment and path planning. This dissertation presents a framework for studying integrated assignment and path planning and then moves on to suggest an exact
Kinetic constrained optimization of the golf swing hub path.
Nesbit, Steven M; McGinnis, Ryan S
2014-12-01
This study details an optimization of the golf swing, where the hand path and club angular trajectories are manipulated. The optimization goal was to maximize club head velocity at impact within the interaction kinetic limitations (force, torque, work, and power) of the golfer as determined through the analysis of a typical swing using a two-dimensional dynamic model. The study was applied to four subjects with diverse swing capabilities and styles. It was determined that it is possible for all subjects to increase their club head velocity at impact within their respective kinetic limitations through combined modifications to their respective hand path and club angular trajectories. The manner of the modifications, the degree of velocity improvement, the amount of kinetic reduction, and the associated kinetic limitation quantities were subject dependent. By artificially minimizing selected kinetic inputs within the optimization algorithm, it was possible to identify swing trajectory characteristics that indicated relative kinetic weaknesses of a subject. Practical implications are offered based upon the findings of the study. Key PointsThe hand path trajectory is an important characteristic of the golf swing and greatly affects club head velocity and golfer/club energy transfer.It is possible to increase the energy transfer from the golfer to the club by modifying the hand path and swing trajectories without increasing the kinetic output demands on the golfer.It is possible to identify relative kinetic output strengths and weakness of a golfer through assessment of the hand path and swing trajectories.Increasing any one of the kinetic outputs of the golfer can potentially increase the club head velocity at impact.The hand path trajectory has important influences over the club swing trajectory.
Bench Testing Results for the Electrical PCM-Assisted Thermal Heating System (ePATHS)
LaClair, Tim J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gao, Zhiming [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Abdelaziz, Omar [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
2016-04-20
Bench testing of the Electrical PCM-Assisted Thermal Heating System (ePATHS) was completed at the Building Technologies Research and Integration Center (BTRIC) at the Oak Ridge National Laboratory (ORNL). The ePATHS is a thermal energy storage device designed to reduce the energy required from the battery for cabin heating of electric vehicles (EVs) and plug-in hybrid electric vehicles (PHEVs). ORNL s testing of the ePATHS assessed three main aspects of operation of the device: 1.ePATHS charging evaluation: measure the time to charge and the energy input needed to fully charge the PCM for a range of different ambient conditions. 2.ePATHS Discharge Evaluations: measure the energy provided by the PCM HX, both during mode 1 and mode 2 operation, and confirm the cabin heating duration that can be provided by the ePATHS. This is the primary evaluation to validate the system performance, and an array of multiple ambient conditions and operating scenarios were tested. 3.Evaluation of Thermal Losses from the ePATHS during Cold Soak: this test will evaluate the performance of the insulation system for the ePATHS. The charged ePATHS undergoes a long-term soak in cold ambient temperature conditions, and the heat losses will be evaluated to validate that the performance meets the maximum energy loss requirement.
Hierarchical path planning and control of a small fixed-wing UAV: Theory and experimental validation
Jung, Dongwon
2007-12-01
Recently there has been a tremendous growth of research emphasizing control of unmanned aerial vehicles (UAVs) either in isolation or in teams. As a matter of fact, UAVs increasingly find their way into military and law enforcement applications (e.g., reconnaissance, remote delivery of urgent equipment/material, resource assessment, environmental monitoring, battlefield monitoring, ordnance delivery, etc.). This trend will continue in the future, as UAVs are poised to replace the human-in-the-loop during dangerous missions. Civilian applications of UAVs are also envisioned such as crop dusting, geological surveying, search and rescue operations, etc. In this thesis we propose a new online multiresolution path planning algorithm for a small UAV with limited on-board computational resources. The proposed approach assumes that the UAV has detailed information of the environment and the obstacles only in its vicinity. Information about far-away obstacles is also available, albeit less accurately. The proposed algorithm uses the fast lifting wavelet transform (FLWT) to get a multiresolution cell decomposition of the environment, whose dimension is commensurate to the on-board computational resources. A topological graph representation of the multiresolution cell decomposition is constructed efficiently, directly from the approximation and detail wavelet coefficients. Dynamic path planning is sequentially executed for an optimal path using the A* algorithm over the resulting graph. The proposed path planning algorithm is implemented on-line on a small autopilot. Comparisons with the standard D*-lite algorithm are also presented. We also investigate the problem of generating a smooth, planar reference path from a discrete optimal path. Upon the optimal path being represented as a sequence of cells in square geometry, we derive a smooth B-spline path that is constrained inside a channel that is induced by the geometry of the cells. To this end, a constrained optimization
Extracting Critical Path Graphs from MPI Applications
Schulz, M
2005-07-27
The critical path is one of the fundamental runtime characteristics of a parallel program. It identifies the longest execution sequence without wait delays. In other words, the critical path is the global execution path that inflicts wait operations on other nodes without itself being stalled. Hence, it dictates the overall runtime and knowing it is important to understand an application's runtime and message behavior and to target optimizations. We have developed a toolset that identifies the critical path of MPI applications, extracts it, and then produces a graphical representation of the corresponding program execution graph to visualize it. To implement this, we intercept all MPI library calls, use the information to build the relevant subset of the execution graph, and then extract the critical path from there. We have applied our technique to several scientific benchmarks and successfully produced critical path diagrams for applications running on up to 128 processors.
Strategic Team AI Path Plans: Probabilistic Pathfinding
Tng C. H. John
2008-01-01
Full Text Available This paper proposes a novel method to generate strategic team AI pathfinding plans for computer games and simulations using probabilistic pathfinding. This method is inspired by genetic algorithms (Russell and Norvig, 2002, in that, a fitness function is used to test the quality of the path plans. The method generates high-quality path plans by eliminating the low-quality ones. The path plans are generated by probabilistic pathfinding, and the elimination is done by a fitness test of the path plans. This path plan generation method has the ability to generate variation or different high-quality paths, which is desired for games to increase replay values. This work is an extension of our earlier work on team AI: probabilistic pathfinding (John et al., 2006. We explore ways to combine probabilistic pathfinding and genetic algorithm to create a new method to generate strategic team AI pathfinding plans.
Path modeling and process control
Høskuldsson, Agnar; Rodionova, O.; Pomerantsev, A.
2007-01-01
and having three or more stages. The methods are applied to a process control of a multi-stage production process having 25 variables and one output variable. When moving along the process, variables change their roles. It is shown how the methods of path modeling can be applied to estimate variables...... of the next stage with the purpose of obtaining optimal or almost optimal quality of the output variable. An important aspect of the methods presented is the possibility of extensive graphic analysis of data that can provide the engineer with a detailed view of the multi-variate variation in data.......Many production processes are carried out in stages. At the end of each stage, the production engineer can analyze the intermediate results and correct process parameters (variables) of the next stage. Both analysis of the process and correction to process parameters at next stage should...
The Logic Behind Feynman's Paths
García Álvarez, Edgardo T.
The classical notions of continuity and mechanical causality are left in order to reformulate the Quantum Theory starting from two principles: (I) the intrinsic randomness of quantum process at microphysical level, (II) the projective representations of symmetries of the system. The second principle determines the geometry and then a new logic for describing the history of events (Feynman's paths) that modifies the rules of classical probabilistic calculus. The notion of classical trajectory is replaced by a history of spontaneous, random and discontinuous events. So the theory is reduced to determining the probability distribution for such histories accordingly with the symmetries of the system. The representation of the logic in terms of amplitudes leads to Feynman rules and, alternatively, its representation in terms of projectors results in the Schwinger trace formula.
Innovation paths in wind power
Lema, Rasmus; Nordensvärd, Johan; Urban, Frauke
Denmark and Germany both make substantial investments in low carbon innovation, not least in the wind power sector. These investments in wind energy are driven by the twin objectives of reducing carbon emissions and building up international competitive advantage. Support for wind power dates back...... between Denmark and Germany when it comes to innovation pathways, both in technological and organisational innovation. In turbine technology, the similarities are the constant increase in turbine size and quality. The key difference to be found is the relative importance of different turbine designs....... The ‘Danish Design’ remains the global standard. The direct drive design, while uncommon in Denmark, dominates the German installation base. Direct drive technology has thus emerged as a distinctly German design and sub-trajectory within the overall technological innovation path. When it comes to organising...
Li ZENG; Xiang-Tian KONG; Jin-Wei SU; Tong-Li XIA; Yan-Qun NA; Ying-Lu GUO
2001-01-01
To explore the usefulness of proliferating cell nuclear antigen proliferating index (PCNA PI) in the pathological diagnosis and treatment of male infertility. Methods: Testicular biopsy specimen obtained from 48 cases of male infertility and 2 normal controls were fixed and embedded. The sections were stained with anti-PCNA monoclonal antibodies or haematoxylin/eosin. Proliferating index (PI), expressed as the percentage of germ-cell nuclei positively stained with PCNA antibody, was assessed from more than 20 seminiferous tubules or 600 germ-cells. Results: The infertile patients were divided into 4 groups: Group 1, normal spermatogenesis ( 14 cases); Group 2, hypospermatogenesis (16 cases); Group 3, germinal arrest (10 cases); Group 4, Sertoli cell only syndrome (8 cases). The PCNA PI of normal control testis was 86.5% (mean value). Group 3 had a significantly lower PCNA PI (29.8%) than normal testis; Group 1 and 2 had similar Pis (82.3% and 82.3%, respectively) as the control testis. PI of the negative control (Group 4) was 0 as no germ-cells were found. Conclusion: PCNA PI is useful for assessing germ-cell kinetics, especially for pathological diagnosis of germinal arrest which is difficult to differentiate by routine HE staining technique. In germinal arrest, there is a significantly lowered PCNA PI, which is an indication of DNA synthesis deterioration, suggesting the use of therapies be different from those for hypospermatogenesis.
Design of active N-path filters
Darvishi, Milad; Zee, van der Ronan; Nauta, Bram
2013-01-01
A design methodology for synthesis of active N-path bandpass filters is introduced. Based on this methodology, a 0.1-to-1.2 GHz tunable 6th-order N-path channel-select filter in 65 nm LP CMOS is introduced. It is based on coupling N-path filters with gyrators, achieving a “flat” passband shape and h
Path Planning Control for Mobile Robot
Amenah A.H. Salih
2011-01-01
Full Text Available Autonomous motion planning is important area of robotics research. This type of planning relieves human operator from tedious job of motion planning. This reduces the possibility of human error and increase efficiency of whole process. This research presents a new algorithm to plan path for autonomous mobile robot based on image processing techniques by using wireless camera that provides the desired image for the unknown environment . The proposed algorithm is applied on this image to obtain a optimal path for the robot. It is based on the observation and analysis of the obstacles that lying in the straight path between the start and the goal point by detecting these obstacles, analyzing and studying their shapes, positions and points of intersection with the straight path to find the nearly optimal path which connects the start and the goal point.This work has theoretical part and experimental part. The theoretical part includes building a MATLAB program which is applied to environment image to find the nearly optimal path .MATLAB - C++.NET interface is accomplished then to supply the path information for C++.NET program which is done for programming the pioneer mobile robot to achieve the desired path. The experimental part includes using wireless camera that takes an image for the environment and send it to the computer which processes this image and sends ( by wireless connection the resulted path information to robot which programmed in C++.NET program to walk according to this path.So, the overall system can be represented by:Wireless camera computer wireless connection for the mobile robot .The experimental work including some experiments shows that the developed mobile robot (pioneer p3-dx travels successfully from the start point and reach the goal point across the optimal path (according to time and power which is obtained as result of the proposed path planning algorithm introduced in this paper.
A note on the path interval distance.
Coons, Jane Ivy; Rusinko, Joseph
2016-06-01
The path interval distance accounts for global congruence between locally incongruent trees. We show that the path interval distance provides a lower bound for the nearest neighbor interchange distance. In contrast to the Robinson-Foulds distance, random pairs of trees are unlikely to be maximally distant from one another under the path interval distance. These features indicate that the path interval distance should play a role in phylogenomics where the comparison of trees on a fixed set of taxa is becoming increasingly important.
Continuous-Discrete Path Integral Filtering
Bhashyam Balaji
2009-08-01
Full Text Available A summary of the relationship between the Langevin equation, Fokker-Planck-Kolmogorov forward equation (FPKfe and the Feynman path integral descriptions of stochastic processes relevant for the solution of the continuous-discrete filtering problem is provided in this paper. The practical utility of the path integral formula is demonstrated via some nontrivial examples. Specifically, it is shown that the simplest approximation of the path integral formula for the fundamental solution of the FPKfe can be applied to solve nonlinear continuous-discrete filtering problems quite accurately. The Dirac-Feynman path integral filtering algorithm is quite simple, and is suitable for real-time implementation.
Cooperative path planning of unmanned aerial vehicles
Tsourdos, Antonios; Shanmugavel, Madhavan
2010-01-01
An invaluable addition to the literature on UAV guidance and cooperative control, Cooperative Path Planning of Unmanned Aerial Vehicles is a dedicated, practical guide to computational path planning for UAVs. One of the key issues facing future development of UAVs is path planning: it is vital that swarm UAVs/ MAVs can cooperate together in a coordinated manner, obeying a pre-planned course but able to react to their environment by communicating and cooperating. An optimized path is necessary in order to ensure a UAV completes its mission efficiently, safely, and successfully.
Langevin equation path integral ground state.
Constable, Steve; Schmidt, Matthew; Ing, Christopher; Zeng, Tao; Roy, Pierre-Nicholas
2013-08-15
We propose a Langevin equation path integral ground state (LePIGS) approach for the calculation of ground state (zero temperature) properties of molecular systems. The approach is based on a modification of the finite temperature path integral Langevin equation (PILE) method (J. Chem. Phys. 2010, 133, 124104) to the case of open Feynman paths. Such open paths are necessary for a ground state formulation. We illustrate the applicability of the method using model systems and the weakly bound water-parahydrogen dimer. We show that the method can lead to converged zero point energies and structural properties.
Techniques and applications of path integration
Schulman, L S
2005-01-01
A book of techniques and applications, this text defines the path integral and illustrates its uses by example. It is suitable for advanced undergraduates and graduate students in physics; its sole prerequisite is a first course in quantum mechanics. For applications requiring specialized knowledge, the author supplies background material.The first part of the book develops the techniques of path integration. Topics include probability amplitudes for paths and the correspondence limit for the path integral; vector potentials; the Ito integral and gauge transformations; free particle and quadra
A.P. Dutra; G.M. Azevedo Júnior; Schmitt, F. C.; G.D. Cassali
2008-01-01
Three methods for the analysis of cell proliferation, mitotic index/10 high-power fields (10 HPF), mitotic index/four sets of 10 HPF (40 HPF), and MIB-1 index were evaluated in a series of canine mammary gland tumors, as well as the possible correlation between them. Fifty-six canine mammary gland tumors, including 23 benign and 33 malignant, were studied. In addition, the prognostic impact of mitotic index/10 HPF, and histological malignancy grade were evaluated in 17 malignant tumors, being...
Nuclear proliferation and national security in India and Pakistan
Joeck, N.H.A.
1986-01-01
This study develops an inventory of propositions from secondary literature about nuclear proliferation incentives and constraints. From this comprehensive inventory are derived eight dimensions of proliferation. Once a state has acquired the necessary technology and material to develop weapons, the critical factors that motivate proliferation are insecurity, alliance protection, and a threat of national extinction. The eight dimensions are then evaluated with respect to two critical states, India and Pakistan, both of which are on the brink of developing nuclear weapons. Extensive interviews were conducted in the United States, India, and Pakistan of senior Indian, Pakistani, and American military official, diplomats, politicians, scholars, and journalists. Based on these interviews, it is clear that Indians and Pakistanis feel themselves caught in a dilemma. Although the initial motivation for developing weapons was indeed found to be insecurity, as expected, it is generally assumed that the effect of proliferation will in fact be to render both states even less secure than they were before beginning their nuclear programs. India and Pakistan are a critical pair of states as they are in a position to assess the probable consequences of nuclear proliferation and back away from it. In so doing, they could set an example to other states of why nuclear proliferation is not in the security interest of nations.
Recombiant DNA and cell proliferation
Stein, G.S.; Stein, J.L.
1984-01-01
This book contains 13 chapters. Some of the chapter titles are: Expression of Dihydrofolate Reductase and Thymidylate Synthase Genes in Mammalian Cells; Expression of Histone Genes during the Cell Cycle in Human Cells; Regulation of Nonmuscle Actin Gene Expression during Early Development; and Recombinant DNA Approaches to Studying Control of Cell Proliferation: An Overview.
PMP27 PROMOTES PEROXISOMAL PROLIFERATION
MARSHALL, PA; KRIMKEVICH, YI; LARK, RH; DYER, JM; VEENHUIS, M; GOODMAN, JM; Krimkevich, Yelena I.; Lark, Richard H.; Dyer, John M.; Goodman, Joel M.
1995-01-01
Peroxisomes perform many essential functions in eukaryotic cells. The weight of evidence indicates that these organelles divide by budding from preexisting peroxisomes. This process is not understood at the molecular level. Peroxisomal proliferation can be induced in Saccharomyces cerevisiae by olea
Kaplan, Sigal; Prato, Carlo Giacomo
2010-01-01
A behavioural and a modelling framework are proposed for representing route choice from a path set that satisfies travellers’ spatiotemporal constraints. Within the proposed framework, travellers’ master sets are constructed by path generation, consideration sets are delimited according to spatio...... constraints are related to travellers’ socio-economic characteristics and that path choice is related to minimizing time and avoiding congestion....
White Noise Path Integrals in Stochastic Neurodynamics
Carpio-Bernido, M. Victoria; Bernido, Christopher C.
2008-06-01
The white noise path integral approach is used in stochastic modeling of neural activity, where the primary dynamical variables are the relative membrane potentials, while information on transmembrane ionic currents is contained in the drift coefficient. The white noise path integral allows a natural framework and can be evaluated explicitly to yield a closed form for the conditional probability density.
Cost allocation in shortest path games
Voorneveld, M.; Grahn, S.
2001-01-01
A class of cooperative games arising from shortest path problems is dened These shortest path games are shown to be totally balanced and allow a population monotonic allocation scheme Possible methods for obtaining core elements are indicated rst by relating to the allocation rules in taxation and b
The Path of Carbon in Photosynthesis VI.
Calvin, M.
1949-06-30
This paper is a compilation of the essential results of our experimental work in the determination of the path of carbon in photosynthesis. There are discussions of the dark fixation of photosynthesis and methods of separation and identification including paper chromatography and radioautography. The definition of the path of carbon in photosynthesis by the distribution of radioactivity within the compounds is described.
Collaborative path planning for a robotic wheelchair.
Zeng, Qiang; Teo, Chee Leong; Rebsamen, Brice; Burdet, Etienne
2008-11-01
Generating a path to guide a wheelchair's motion faces two challenges. First, the path is located in the human environment and that is usually unstructured and dynamic. Thus, it is difficult to generate a reliable map and plan paths on it by artificial intelligence. Second, the wheelchair, whose task is to carry a human user, should move on a smooth and comfortable path adapted to the user's intentions. To meet these challenges, we propose that the human operator and the robot interact to create and gradually improve a guide path. This paper introduces design tools to enable an intuitive interaction, and reports experiments performed with healthy subjects in order to investigate this collaborative path learning strategy. We analyzed features of the optimal paths and user evaluation in representative conditions. This was complemented by a questionnaire filled out by the subjects after the experiments. The results demonstrate the effectiveness of this approach, and show the utility and complementarity of the tools to design ergonomic guide paths.
Path Minima Queries in Dynamic Weighted Trees
Davoodi, Pooya; Brodal, Gerth Stølting; Satti, Srinivasa Rao
2011-01-01
In the path minima problem on a tree, each edge is assigned a weight and a query asks for the edge with minimum weight on a path between two nodes. For the dynamic version of the problem, where the edge weights can be updated, we give data structures that achieve optimal query time\\todo{what about...
Multi-block and path modelling procedures
Høskuldsson, Agnar
2008-01-01
The author has developed a unified theory of path and multi-block modelling of data. The data blocks are arranged in a directional path. Each data block can lead to one or more data blocks. It is assumed that there is given a collection of input data blocks. Each of them is supposed to describe one...
Two Generations of Path Dependence in Economics?
Madsen, Mogens Ove
2010-01-01
Even if there is no fully articulated and generally accepted theory of Path Dependence it has eagerly been taken up across a wide range of social sciences – primarily coming from economics. Path Dependence is most of all a metaphor that offers reason to believe, that some political, social...
Adaptively Ubiquitous Learning in Campus Math Path
Shih, Shu-Chuan; Kuo, Bor-Chen; Liu, Yu-Lung
2012-01-01
The purposes of this study are to develop and evaluate the instructional model and learning system which integrate ubiquitous learning, computerized adaptive diagnostic testing system and campus math path learning. The researcher first creates a ubiquitous learning environment which is called "adaptive U-learning math path system". This…
Graphic method for analyzing common path interferometers
Glückstad, J.
1998-01-01
Common path interferometers are widely used for visualizing phase disturbances and fluid flows. They are attractive because of the inherent simplicity and robustness in the setup. A graphic method will be presented for analyzing and optimizing filter parameters in common path interferometers....
Robot path planning using genetic algorithms
无
2001-01-01
Presents a strategy for soccer robot path planning using genetic algorithms for which, real number coding method is used, to overcome the defects of binary coding method, and the double crossover operation a dopted, to avoid the common defect of early convergence and converge faster than the standard genetic algo rithms concludes from simulation results that the method is effective for robot path planning.
Consistent Partial Least Squares Path Modeling
Dijkstra, Theo K.; Henseler, Jörg
2015-01-01
This paper resumes the discussion in information systems research on the use of partial least squares (PLS) path modeling and shows that the inconsistency of PLS path coefficient estimates in the case of reflective measurement can have adverse consequences for hypothesis testing. To remedy this, the
Inked Careers: Tattooing Professional Paths
Gabriela DeLuca
2016-12-01
Full Text Available The concept of career has an interdisciplinary and historical constitution, which includes persons, groups, organizations and society. Given that, we aim to deepen the interactionist notion of career from the understanding of a deviant path, supported by a theory and a method appropriated to the cited call for interdisciplinary approaches. Dilemmas (Hughes, 1958 and conflicts (Hughes, 1937 emerged as important analytical categories. Although necessary, these two concepts were not sufficient to contemplate analyses in their entirety. For this reason we conceptualized a third possibility of controversy during a career: the inquiries. The study followed the Narrative method to analyze objective and subjective changes during a tattoo artist’s career through interviews and informal conversations carried out over 22 months. The discussion presents three main contributions. Theoretically, a new understanding of the concept of careers, linking past, present and future and the idea of non-linearity of experienced and envisioned careers. Methodologically, suggesting orientations for future career studies such as the use of turning points as a methodological tool and the investigation of deviant fields. Finally, our defense of the interactionist perspective as suitable for career studies, since it allows the investigation of deviant elements.
Decision paths in complex tasks
Galanter, Eugene
1991-01-01
Complex real world action and its prediction and control has escaped analysis by the classical methods of psychological research. The reason is that psychologists have no procedures to parse complex tasks into their constituents. Where such a division can be made, based say on expert judgment, there is no natural scale to measure the positive or negative values of the components. Even if we could assign numbers to task parts, we lack rules i.e., a theory, to combine them into a total task representation. We compare here two plausible theories for the amalgamation of the value of task components. Both of these theories require a numerical representation of motivation, for motivation is the primary variable that guides choice and action in well-learned tasks. We address this problem of motivational quantification and performance prediction by developing psychophysical scales of the desireability or aversiveness of task components based on utility scaling methods (Galanter 1990). We modify methods used originally to scale sensory magnitudes (Stevens and Galanter 1957), and that have been applied recently to the measure of task 'workload' by Gopher and Braune (1984). Our modification uses utility comparison scaling techniques which avoid the unnecessary assumptions made by Gopher and Braune. Formula for the utility of complex tasks based on the theoretical models are used to predict decision and choice of alternate paths to the same goal.
Precision Cleaning - Path to Premier
Mackler, Scott E.
2008-01-01
ITT Space Systems Division s new Precision Cleaning facility provides critical cleaning and packaging of aerospace flight hardware and optical payloads to meet customer performance requirements. The Precision Cleaning Path to Premier Project was a 2007 capital project and is a key element in the approved Premier Resource Management - Integrated Supply Chain Footprint Optimization Project. Formerly precision cleaning was located offsite in a leased building. A new facility equipped with modern precision cleaning equipment including advanced process analytical technology and improved capabilities was designed and built after outsourcing solutions were investigated and found lacking in ability to meet quality specifications and schedule needs. SSD cleans parts that can range in size from a single threaded fastener all the way up to large composite structures. Materials that can be processed include optics, composites, metals and various high performance coatings. We are required to provide verification to our customers that we have met their particulate and molecular cleanliness requirements and we have that analytical capability in this new facility. The new facility footprint is approximately half the size of the former leased operation and provides double the amount of throughput. Process improvements and new cleaning equipment are projected to increase 1st pass yield from 78% to 98% avoiding $300K+/yr in rework costs. Cost avoidance of $350K/yr will result from elimination of rent, IT services, transportation, and decreased utility costs. Savings due to reduced staff expected to net $4-500K/yr.
Gerbertian paths for the Jubilee
Sigismondi, Costantino
2015-04-01
Gerbert before becoming Pope Sylvester II came several times in Rome, as reported in his Letters and in the biography of Richerus. Eight places in Rome can be connected with Gerbertian memories. 1. The Cathedral of St. John in the Lateran where the gravestone of his tumb is still preserved near the Holy Door; 2. the “Basilica Hierusalem” (Santa Croce) where Gerbert had the stroke on May 3rd 1003 which lead him to death on May 12th; 3. the Aventine hill, with the church of the Knights of Malta in the place where the palace of the Ottonian Emperors was located; 4. the church of St. Bartholomew in the Tiber Island built in 997 under Otto III; 5. the Obelisk of Augustus in Montecitorio to remember the relationship between Gerbert, Astronomy and numbers which led the birth of the legends on Gerbert magician; 6. St. Mary Major end of the procession of August 15, 1000; 7. St. Paul outside the walls with the iconography of the Popes and 8. St. Peter's tumb end of all Romaei pilgrimages. This Gerbertian path in Rome suggests one way to accomplish the pilgrimage suggested by Pope Francis in the Bulla Misericordiae Vultus (14) of indiction of the new Jubilee.
Critical Review of Path Integral Formulation
Fujita, Takehisa
2008-01-01
The path integral formulation in quantum mechanics corresponds to the first quantization since it is just to rewrite the quantum mechanical amplitude into many dimensional integrations over discretized coordinates $x_n$. However, the path integral expression cannot be connected to the dynamics of classical mechanics, even though, superficially, there is some similarity between them. Further, the field theory path integral in terms of many dimensional integrations over fields does not correspond to the field quantization. We clarify the essential difference between Feynman's original formulation of path integral in QED and the modern version of the path integral method prevailing in lattice field theory calculations, and show that the former can make a correct second quantization while the latter cannot quantize fields at all and its physical meaning is unknown.
Back-end of the fuel cycle and non-proliferation strategies
Chebeskov, A.N.; Oussanov, V.I.; Iougai, S.V.; Pshakin, G.M. [Institute of Physics and Power Engineering, State Scientific Center of Russian Federation, Obninsk (Russian Federation)
2001-07-01
The paper focuses on the problem of fissile materials proliferation risk estimation. Some methodological approaches to the solution of this task and results of their application for comparison of different nuclear fuel cycle strategies are discussed. The results of comparative assessment of non-proliferation aspects of plutonium utilization alternatives in Russia using system analysis approach are presented. (author)
Reaction path synthesis methodology for waste minimization
HU; Shanying; LI; Mingheng; LI; Yourun; SHEN; Jingzhu; LIU
2004-01-01
It is a key step for reducing waste generation in chemical processes to design optimal reaction paths. In this paper, methods of waste minimization for reaction path synthesis problems are proposed to realize eco-industrial production mode with minimum waste emission. A new conception of simple stoichiometric reaction is presented for reaction path synthesis problem. All simple stoichiometric reactions can be obtained by mathematical transformation for atom matrix of a reaction system. Based on the conception, a two-tier optimization method for complex reaction path synthesis problems is addressed. The first step is to determine the economic optimal overall reactions, and the second step to decompose each overall reaction into several sub-reactions and find out the best thermodynamic feasible reaction path. Further, a method of reaction path synthesis with waste closed-cycle is proposed based on simple stoichiometric reactions for achieving zero waste emission to poly-generation problem of multi-products. Case studies show that the proposed methods can efficiently solve practical reaction path synthesis problems.
Robot path planning using a genetic algorithm
Cleghorn, Timothy F.; Baffes, Paul T.; Wang, Liu
1988-01-01
Robot path planning can refer either to a mobile vehicle such as a Mars Rover, or to an end effector on an arm moving through a cluttered workspace. In both instances there may exist many solutions, some of which are better than others, either in terms of distance traversed, energy expended, or joint angle or reach capabilities. A path planning program has been developed based upon a genetic algorithm. This program assumes global knowledge of the terrain or workspace, and provides a family of good paths between the initial and final points. Initially, a set of valid random paths are constructed. Successive generations of valid paths are obtained using one of several possible reproduction strategies similar to those found in biological communities. A fitness function is defined to describe the goodness of the path, in this case including length, slope, and obstacle avoidance considerations. It was found that with some reproduction strategies, the average value of the fitness function improved for successive generations, and that by saving the best paths of each generation, one could quite rapidly obtain a collection of good candidate solutions.
Nonholonomic catheter path reconstruction using electromagnetic tracking
Lugez, Elodie; Sadjadi, Hossein; Akl, Selim G.; Fichtinger, Gabor
2015-03-01
Catheter path reconstruction is a necessary step in many clinical procedures, such as cardiovascular interventions and high-dose-rate brachytherapy. To overcome limitations of standard imaging modalities, electromagnetic tracking has been employed to reconstruct catheter paths. However, tracking errors pose a challenge in accurate path reconstructions. We address this challenge by means of a filtering technique incorporating the electromagnetic measurements with the nonholonomic motion constraints of the sensor inside a catheter. The nonholonomic motion model of the sensor within the catheter and the electromagnetic measurement data were integrated using an extended Kalman filter. The performance of our proposed approach was experimentally evaluated using the Ascension's 3D Guidance trakStar electromagnetic tracker. Sensor measurements were recorded during insertions of an electromagnetic sensor (model 55) along ten predefined ground truth paths. Our method was implemented in MATLAB and applied to the measurement data. Our reconstruction results were compared to raw measurements as well as filtered measurements provided by the manufacturer. The mean of the root-mean-square (RMS) errors along the ten paths was 3.7 mm for the raw measurements, and 3.3 mm with manufacturer's filters. Our approach effectively reduced the mean RMS error to 2.7 mm. Compared to other filtering methods, our approach successfully improved the path reconstruction accuracy by exploiting the sensor's nonholonomic motion constraints in its formulation. Our approach seems promising for a variety of clinical procedures involving reconstruction of a catheter path.
Using a reflection model for modeling the dynamic feedback path of digital hearing aids
Ma, Guilin; Gran, Fredrik; Jacobsen, Finn;
2010-01-01
Feedback whistling is one of the severe problems with hearing aids, especially in dynamic situations when the users hug, pick up a telephone, etc. This paper investigates the properties of the dynamic feedback paths of digital hearing aids and proposes a model based on a reflection assumption...... gain. The method is also extended to dual-microphone hearing aids to assess the possibility of relating the two dynamic feedback paths through the reflection model. However, it is found that in a complicated acoustic environment, the relation between the two feedback paths can be very intricate...
Aircraft Engine Gas Path Diagnostic Methods: Public Benchmarking Results
Simon, Donald L.; Borguet, Sebastien; Leonard, Olivier; Zhang, Xiaodong (Frank)
2013-01-01
Recent technology reviews have identified the need for objective assessments of aircraft engine health management (EHM) technologies. To help address this issue, a gas path diagnostic benchmark problem has been created and made publicly available. This software tool, referred to as the Propulsion Diagnostic Method Evaluation Strategy (ProDiMES), has been constructed based on feedback provided by the aircraft EHM community. It provides a standard benchmark problem enabling users to develop, evaluate and compare diagnostic methods. This paper will present an overview of ProDiMES along with a description of four gas path diagnostic methods developed and applied to the problem. These methods, which include analytical and empirical diagnostic techniques, will be described and associated blind-test-case metric results will be presented and compared. Lessons learned along with recommendations for improving the public benchmarking processes will also be presented and discussed.
Geoff Brindley
2005-01-01
@@ Introduction TERMINOLOGY AND KEY CONCEPTS The term assessment refers to a variety of ways of collecting information on a learner's language ability or achievement. Although testing and assessment are often used interchangeably, the latter is an umbrella term encompassing measurement instruments administered on a ‘one-off’ basis such as tests, as well as qualitative methods of monitoring and recording student learning such as observation, simulations of project work. Assessment is also distinguished from evaluation which is concerned with the overall language programme and not just with what individual students have learnt. Proficiency assessment refers to the assessment of general language abilities acquired by the learner independent of a course of study.This kind of assessment is often done through the administration of standardised commercial language-proficency tests. On the other hand, assessment of achievement aims to establish what a student had learned in relation to a particular course or curriculum (thus frequently carried out by the teacher) .Achievement assesssment may be based either on the specific content of the course or on the course objectives (Hughes 1989).
Fluctuating paths and fields Festschrift Kleinert (Hagen)
Bachmann, M; Schmidt, H J; Janke, W
2001-01-01
This volume covers the following fields: path integrals, quantum field theory, variational perturbation theory, phase transitions and critical phenomena, topological defects, strings and membranes, gravitation and cosmology. Contents: Path Integrals and Quantum Mechanics: Semiclassical Quantum Mechanics: A Path-Integral Approach (B R Holstein); Conjecture on the Reality of Spectra of Non-Hermitian Hamiltonians (C M Bender et al.); Time-Transformation Approach to q -Deformed Objects (A Inomata); Characterizing Volume Forms (P Cartier et al.); Vassiliev Invariants and Functional Integration (L H
Path integral representations on the complex sphere
Grosche, C. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik
2007-08-15
In this paper we discuss the path integral representations for the coordinate systems on the complex sphere S{sub 3C}. The Schroedinger equation, respectively the path integral, separates in exactly 21 orthogonal coordinate systems. We enumerate these coordinate systems and we are able to present the path integral representations explicitly in the majority of the cases. In each solution the expansion into the wave-functions is stated. Also, the kernel and the corresponding Green function can be stated in closed form in terms of the invariant distance on the sphere, respectively on the hyperboloid. (orig.)
Non Abelian Dual Maps in Path Space
Martin, I
1999-01-01
We study an extension of the procedure to construct duality transformations among abelian gauge theories to the non abelian case using a path space formulation. We define a pre-dual functional in path space and introduce a particular non local map among Lie algebra valued 1-form functionals that reduces to the ordinary Hodge-* duality map of the abelian theories. Further, we establish a full set of equations on path space representing the ordinary Yang Mills equations and Bianchi identities of non abelian gauge theories of 4-dimensional euclidean space.
Extending the application of critical path methods.
Coffey, R J; Othman, J E; Walters, J I
1995-01-01
Most health care organizations are using critical pathways in an attempt to reduce the variation in patient care, improve quality, enhance communication, and reduce costs. Virtually all of the critical path efforts to date have developed tables of treatments, medications, and so forth by day and have displayed them in a format known as a Gantt chart. This article presents a methodology for identifying the true "time-limiting" critical path, describes three additional methods for presenting the information--the network, precedent, and resource formats--and shows how these can significantly enhance current critical path efforts.
INVESTMENT DEVELOPMENT PATH – CONCEPT AND TERMS
Ovidiu Serafim TRUFIN
2015-04-01
Full Text Available This article aims to analyze and explain the traditional model of Investment Development Path with new teoretical approaches. Investment Develoment Path is the latest theory about foreign direct investment and explains the relationship between a country’s development level and international investment position of a country. It has become a necessity in this research field of Romanian economy to establish a idiosyncratic model for evolution of inflows and outflows of Foreign Direct Investments after 1990. Also, persistent confusion between static and dynamic nature in using appropriate economic Romanian terms is removed. General theoretical approach is enhanced with new elements of schematic theorizing of Stages of Investment Development Path.
Rotational path removable partial denture design.
Jacobson, T E; Krol, A J
1982-10-01
A detailed description of a rotational path of insertion design for removable partial dentures has been presented. By minimizing the use of conventional clasps, this technique offers some advantages. Rotational path designs may minimize adverse periodontal response to a removable partial denture by reducing plaque accumulation and may be applied in esthetically demanding situations. The design concept involves the use of rigid retentive components that gain access to undercut areas through a rotational path of insertion. These rigid components satisfy the basic requirements of conventional direct retained design.
Quantum Adiabatic Evolution Algorithms with Different Paths
Farhi, E; Gutmann, S; Farhi, Edward; Goldstone, Jeffrey; Gutmann, Sam
2002-01-01
In quantum adiabatic evolution algorithms, the quantum computer follows the ground state of a slowly varying Hamiltonian. The ground state of the initial Hamiltonian is easy to construct; the ground state of the final Hamiltonian encodes the solution of the computational problem. These algorithms have generally been studied in the case where the "straight line" path from initial to final Hamiltonian is taken. But there is no reason not to try paths involving terms that are not linear combinations of the initial and final Hamiltonians. We give several proposals for randomly generating new paths. Using one of these proposals, we convert an algorithmic failure into a success.
Test Derivation Through Critical Path Transitions
李卫东; 魏道政
1992-01-01
In this paper, a new technique called test derivation is presented,aiming at the promotion of the random testing efficiency for combinational circuits,Combined with a fault simulator based on critical path tracing method,we introduce the concept of seed test derivation and attempt to generate a group of new tests from the seed test by means of critical path transition.The neccessary conditions and efficient algorithms are proposed to guarantee the usefulness of the newly derived tests and the correctness of the critical path transitions.Also,examples are given to demonstrate the effectiveness of the technique.
A.P. Dutra
2008-12-01
Full Text Available Three methods for the analysis of cell proliferation, mitotic index/10 high-power fields (10 HPF, mitotic index/four sets of 10 HPF (40 HPF, and MIB-1 index were evaluated in a series of canine mammary gland tumors, as well as the possible correlation between them. Fifty-six canine mammary gland tumors, including 23 benign and 33 malignant, were studied. In addition, the prognostic impact of mitotic index/10 HPF, and histological malignancy grade were evaluated in 17 malignant tumors, being seven ductal and 10 metaplastic carcinomas. The three methods used to evaluate cell proliferation were correlated with the prognostic impact of mitotic index/10 HPF and histological malignancy grade. The results showed a strong association between mitotic figure counts and MIB-1 index (PAvaliaram-se três métodos de proliferação celular, índice mitótico/10 campos de grande aumento (10 CGA, quatro vezes 10 CGA (40 CGA e índice de marcação por MIB-1, em uma série de tumores mamários caninos, e as possíveis correlações entre estes métodos. Foram estudados 56 tumores mamários caninos, 23 benignos e 33 malignos. Foi também avaliado o impacto prognóstico do índice mitótico (10 CGA e o grau histológico maligno em 17 tumores malignos, sete carcinomas ductais e 10 carcinomas metaplásicos. A correlação entre os três métodos para avaliar a proliferação celular e o impacto prognóstico do índice mitótico por 10 CGA e o grau histológico maligno foi realizada. Os resultados mostraram que existe uma forte associação entre contagem de mitose e o índice de marcação por MIB-1(P<0,0001 e correlação entre contagem de mitoses em 40 CGA e índice de marcação por MIB-1 e entre índice mitótico em 10 CGA e 40 CGA (P<0,05. Observou-se correlação entre os três métodos de avaliação da proliferação celular e os fatores prognósticos semelhante aos estudos de câncer de mama humano.
Relationship between Cell Proliferation and Apoptosis in Cervical Carcinoma
无
2002-01-01
Objective To study the relationship between cell proliferation and apoptosis in cervical carcinoma and its clinical significance.Methods The cell proliferation and apoptosis of cervical epithelial cells in archival formalin-fixed,paraffin-embedded tissue sections of normal cervix ,cervical intraepithelial neoplasms(CN) and cervical squamous carcinoma were tested by using immunohistochemistry assay and DNA nick end-labeling technigue.The proliferation index(PI) and apoptosis index(AI) were calculated and their correlation with clinical and pathological data was analyzed. Results PI was gradually increased,but the AI and AI/PI ratio decreased from normal cervical epithelium,CIN to cervical carcinoma. There was no significant relationship among cell proliferation,apoptosis,clinical stages and pathological grades.High AI was always asso-ciated with a poor prognosis of the patients. Conclusion Cell proliferation and apoptosis allow to distinguish among normal epithelium,CIN and cervical carcinoma and are useful for the assessment of the malignant potential of tumor tissues.
Distributed multiple path routing in complex networks
Chen, Guang; Wang, San-Xiu; Wu, Ling-Wei; Mei, Pan; Yang, Xu-Hua; Wen, Guang-Hui
2016-12-01
Routing in complex transmission networks is an important problem that has garnered extensive research interest in the recent years. In this paper, we propose a novel routing strategy called the distributed multiple path (DMP) routing strategy. For each of the O-D node pairs in a given network, the DMP routing strategy computes and stores multiple short-length paths that overlap less with each other in advance. And during the transmission stage, it rapidly selects an actual routing path which provides low transmission cost from the pre-computed paths for each transmission task, according to the real-time network transmission status information. Computer simulation results obtained for the lattice, ER random, and scale-free networks indicate that the strategy can significantly improve the anti-congestion ability of transmission networks, as well as provide favorable routing robustness against partial network failures.
Local-time representation of path integrals.
Jizba, Petr; Zatloukal, Václav
2015-12-01
We derive a local-time path-integral representation for a generic one-dimensional time-independent system. In particular, we show how to rephrase the matrix elements of the Bloch density matrix as a path integral over x-dependent local-time profiles. The latter quantify the time that the sample paths x(t) in the Feynman path integral spend in the vicinity of an arbitrary point x. Generalization of the local-time representation that includes arbitrary functionals of the local time is also provided. We argue that the results obtained represent a powerful alternative to the traditional Feynman-Kac formula, particularly in the high- and low-temperature regimes. To illustrate this point, we apply our local-time representation to analyze the asymptotic behavior of the Bloch density matrix at low temperatures. Further salient issues, such as connections with the Sturm-Liouville theory and the Rayleigh-Ritz variational principle, are also discussed.
Riemann Curvature Tensor and Closed Geodesic Paths
Morganstern, Ralph E.
1977-01-01
Demonstrates erroneous results obtained if change in a vector under parallel transport about a closed path in Riemannian spacetime is made in a complete circuit rather than just half a circuit. (Author/SL)
Non-classical paths in interference experiments
Sawant, Rahul; Sinha, Aninda; Sinha, Supurna; Sinha, Urbasi
2014-01-01
In a double slit interference experiment, the wave function at the screen with both slits open is not exactly equal to the sum of the wave functions with the slits individually open one at a time. The three scenarios represent three different boundary conditions and as such, the superposition principle should not be applicable. However, most well known text books in quantum mechanics implicitly and/or explicitly use this assumption which is only approximately true. In our present study, we have used the Feynman path integral formalism to quantify contributions from non-classical paths in quantum interference experiments which provide a measurable deviation from a naive application of the superposition principle. A direct experimental demonstration for the existence of these non-classical paths is hard. We find that contributions from such paths can be significant and we propose simple three-slit interference experiments to directly confirm their existence.
Nonclassical Paths in Quantum Interference Experiments
Sawant, Rahul; Samuel, Joseph; Sinha, Aninda; Sinha, Supurna; Sinha, Urbasi
2014-09-01
In a double slit interference experiment, the wave function at the screen with both slits open is not exactly equal to the sum of the wave functions with the slits individually open one at a time. The three scenarios represent three different boundary conditions and as such, the superposition principle should not be applicable. However, most well-known text books in quantum mechanics implicitly and/or explicitly use this assumption that is only approximately true. In our present study, we have used the Feynman path integral formalism to quantify contributions from nonclassical paths in quantum interference experiments that provide a measurable deviation from a naive application of the superposition principle. A direct experimental demonstration for the existence of these nonclassical paths is difficult to present. We find that contributions from such paths can be significant and we propose simple three-slit interference experiments to directly confirm their existence.
Path Integral Approach to Atomic Collisions
Harris, Allison
2016-09-01
The Path Integral technique is an alternative formulation of quantum mechanics that is based on a Lagrangian approach. In its exact form, it is completely equivalent to the Hamiltonian-based Schrödinger equation approach. Developed by Feynman in the 1940's, following inspiration from Dirac, the path integral approach has been widely used in high energy physics, quantum field theory, and statistical mechanics. However, only in limited cases has the path integral approach been applied to quantum mechanical few-body scattering. We present a theoretical and computational development of the path integral method for use in the study of atomic collisions. Preliminary results are presented for some simple systems. Ultimately, this approach will be applied to few-body ion-atom collisions. Work supported by NSF grant PHY-1505217.
Predicting missing links via significant paths
Zhu, Xuzhen; Cai, Shimin; Huang, Junming; Zhou, Tao
2014-01-01
Link prediction plays an important role in understanding intrinsic evolving mechanisms of networks. With the belief that the likelihood of the existence of a link between two nodes is strongly related with their similarity, many methods have been proposed to calculate node similarity based on node attributes and/or topological structures. Among a large variety of methods that take into account paths connecting the target pair of nodes, most of which neglect the heterogeneity of those paths. Our hypothesis is that a path consisting of small-degree nodes provides a strong evidence of similarity between two ends, accordingly, we propose a so-called sig- nificant path index in this Letter to leverage intermediate nodes' degrees in similarity calculation. Empirical experiments on twelve disparate real networks demonstrate that the proposed index outperforms the mainstream link prediction baselines.
Aircraft Path Planning under Adverse Weather Conditions
Xie Z.
2016-01-01
Full Text Available In recent years, flight safety is still one of the main issues for all airlines. En route civil airplanes may encounter adverse weather conditions. Some fatal airplane accidents happened because of the weather disturbance. Moreover, we should also design path to avoid the prohibited area. Therefore a good path planning algorithm plays an increasingly important role in air traffic management. An efficient path planning algorithm can help the plane to avoid severe weather conditions, restricted areas and moving obstacles to ensure the safety of the cabin crews and passengers. Here, we build our algorithm based on the A* search algorithm. Moreover, our algorithm can also find the path with least energy costs. As a result, our algorithm can improve the safety operation of the airplanes and reduce the workload of pilots and air traffic controllers.
Path integration in relativistic quantum mechanics
Redmount, I H; Redmount, Ian H.; Suen, Wai-Mo
1993-01-01
The simple physics of a free particle reveals important features of the path-integral formulation of relativistic quantum theories. The exact quantum-mechanical propagator is calculated here for a particle described by the simple relativistic action proportional to its proper time. This propagator is nonvanishing outside the light cone, implying that spacelike trajectories must be included in the path integral. The propagator matches the WKB approximation to the corresponding configuration-space path integral far from the light cone; outside the light cone that approximation consists of the contribution from a single spacelike geodesic. This propagator also has the unusual property that its short-time limit does not coincide with the WKB approximation, making the construction of a concrete skeletonized version of the path integral more complicated than in nonrelativistic theory.
Path dependence and independent utility regulation
Ibsen, Christian Lyhne; Skovgaard Poulsen, Lauge
2007-01-01
The establishment of the Danish independent regulatory authorities for the energy and telecommunications sectors was based upon EU directives as part of their liberalisation process. Following the concepts of transaction costs and path dependency this article analyses differences in independence...
Northern Pintail - Flight Path Telemetry [ds117
California Department of Resources — North-south flight paths of radio-tagged female northern pintails were monitored in a section of Highway 152 near Los Banos, California during 4 and 11 November and...
Path integral distance for data interpretation
Volchenkov, D
2015-01-01
The process of data interpretation is always based on the implicit introduction of equivalence relations on the set of walks over the database. Every equivalence relation on the set of walks specifies a Markov chain describing the transitions of a discrete time random walk. In order to geometrize and interpret the data, we propose the new distance between data units defined as a "Feynman path integral", in which all possible paths between any two nodes in a graph model of the data are taken into account, although some paths are more preferable than others. Such a path integral distance approach to the analysis of databases has proven its efficiency and success, especially on multivariate strongly correlated data where other methods fail to detect structural components (urban planning, historical language phylogenies, music, street fashion traits analysis, etc. ). We believe that it would become an invaluable tool for the intelligent complexity reduction and big data interpretation.
Modeling DNA Dynamics by Path Integrals
Zoli, Marco
2013-01-01
Complementary strands in DNA double helix show temporary fluctuational openings which are essential to biological functions such as transcription and replication of the genetic information. Such large amplitude fluctuations, known as the breathing of DNA, are generally localized and, microscopically, are due to the breaking of the hydrogen bonds linking the base pairs (\\emph{bps}). I apply imaginary time path integral techniques to a mesoscopic Hamiltonian which accounts for the helicoidal geometry of a short circular DNA molecule. The \\emph{bps} displacements with respect to the ground state are interpreted as time dependent paths whose amplitudes are consistent with the model potential for the hydrogen bonds. The portion of the paths configuration space contributing to the partition function is determined by selecting the ensemble of paths which fulfill the second law of thermodynamics. Computations of the thermodynamics in the denaturation range show the energetic advantage for the equilibrium helicoidal g...
Noncommutative integrability, paths and quasi-determinants
Di Francesco, Philippe
2010-01-01
In previous work, we showed that the solution of certain systems of discrete integrable equations, notably $Q$ and $T$-systems, is given in terms of partition functions of positively weighted paths, thereby proving the positive Laurent phenomenon of Fomin and Zelevinsky for these cases. This method of solution is amenable to generalization to non-commutative weighted paths. Under certain circumstances, these describe solutions of discrete evolution equations in non-commutative variables: Examples are the corresponding quantum cluster algebras [BZ], the Kontsevich evolution [DFK09b] and the $T$-systems themselves [DFK09a]. In this paper, we formulate certain non-commutative integrable evolutions by considering paths with non-commutative weights, together with an evolution of the weights that reduces to cluster algebra mutations in the commutative limit. The general weights are expressed as Laurent monomials of quasi-determinants of path partition functions, allowing for a non-commutative version of the positiv...
Building a path in cell biology.
Voeltz, Gia; Cheeseman, Iain
2012-11-01
Setting up a new lab is an exciting but challenging prospect. We discuss our experiences in finding a path to tackle some of the key current questions in cell biology and the hurdles that we have encountered along the way.
A chemist building paths to cell biology.
Weibel, Douglas B
2013-11-01
Galileo is reported to have stated, "Measure what is measurable and make measurable what is not so." My group's trajectory in cell biology has closely followed this philosophy, although it took some searching to find this path.
Feasible Path Planning for Autonomous Vehicles
Vu Trieu Minh
2014-01-01
Full Text Available The objective of this paper is to find feasible path planning algorithms for nonholonomic vehicles including flatness, polynomial, and symmetric polynomial trajectories subject to the real vehicle dynamical constraints. Performances of these path planning methods are simulated and compared to evaluate the more realistic and smoother generated trajectories. Results show that the symmetric polynomial algorithm provides the smoothest trajectory. Therefore, this algorithm is recommended for the development of an automatic control for autonomous vehicles.
Competition for shortest paths on sparse graphs.
Yeung, Chi Ho; Saad, David
2012-05-18
Optimal paths connecting randomly selected network nodes and fixed routers are studied analytically in the presence of a nonlinear overlap cost that penalizes congestion. Routing becomes more difficult as the number of selected nodes increases and exhibits ergodicity breaking in the case of multiple routers. The ground state of such systems reveals nonmonotonic complex behaviors in average path length and algorithmic convergence, depending on the network topology, and densities of communicating nodes and routers. A distributed linearly scalable routing algorithm is also devised.
Dressed coordinates: The path-integral approach
Casana, R.; Flores-Hidalgo, G.; Pimentel, B. M.
2007-02-01
The recently introduced dressed coordinates are studied in the path-integral approach. These coordinates are defined in the context of a harmonic oscillator linearly coupled to massless scalar field and it is shown that in this model the dressed coordinates appear as a coordinate transformation preserving the path-integral functional measure. The analysis also generalizes the sum rules established in a previous work.
Create three distinct career paths for innovators.
O'Connor, Gina Colarelli; Corbett, Andrew; Pierantozzi, Ron
2009-12-01
Large companies say they Create Three Distinct want to be Career Paths for Innovators innovative, but they fundamentally mismanage their talent. Expecting innovators to grow along with their projects-from discovery to incubation to acceleration--sets them up to fail. Most people excel at one of the phases, not all three. By allowing innovation employees to develop career paths suited to their strengths, companies will create a sustainable innovation function.
The Feynman Path Goes Monte Carlo
Sauer, Tilman
2001-01-01
Path integral Monte Carlo (PIMC) simulations have become an important tool for the investigation of the statistical mechanics of quantum systems. I discuss some of the history of applying the Monte Carlo method to non-relativistic quantum systems in path-integral representation. The principle feasibility of the method was well established by the early eighties, a number of algorithmic improvements have been introduced in the last two decades.
A novel method for robot path planning
CAI Qiang; LI Hai-sheng; YANG Qin; LI Ji-gang
2009-01-01
Path planning is one of the most important problems in the design of a mobile robot. A novel approach called generalized Voronoi diagrams (GVD) may deal with this matter. First, a method was introduced to normalize the obstacles and present efficient techniques for generating GVDs. Then a best path searching algorithm was presented. Examples implemented were given to indicate the availability of the mentioned algorithms. The approaches in this paper can also be used in applications including visualization, spatial data manipulation, etc.
A Path Algorithm for Constrained Estimation.
Zhou, Hua; Lange, Kenneth
2013-01-01
Many least-square problems involve affine equality and inequality constraints. Although there are a variety of methods for solving such problems, most statisticians find constrained estimation challenging. The current article proposes a new path-following algorithm for quadratic programming that replaces hard constraints by what are called exact penalties. Similar penalties arise in l1 regularization in model selection. In the regularization setting, penalties encapsulate prior knowledge, and penalized parameter estimates represent a trade-off between the observed data and the prior knowledge. Classical penalty methods of optimization, such as the quadratic penalty method, solve a sequence of unconstrained problems that put greater and greater stress on meeting the constraints. In the limit as the penalty constant tends to ∞, one recovers the constrained solution. In the exact penalty method, squared penalties!are replaced by absolute value penalties, and the solution is recovered for a finite value of the penalty constant. The exact path-following method starts at the unconstrained solution and follows the solution path as the penalty constant increases. In the process, the solution path hits, slides along, and exits from the various constraints. Path following in Lasso penalized regression, in contrast, starts with a large value of the penalty constant and works its way downward. In both settings, inspection of the entire solution path is revealing. Just as with the Lasso and generalized Lasso, it is possible to plot the effective degrees of freedom along the solution path. For a strictly convex quadratic program, the exact penalty algorithm can be framed entirely in terms of the sweep operator of regression analysis. A few well-chosen examples illustrate the mechanics and potential of path following. This article has supplementary materials available online.
Decomposing Path : The Nanosyntax of Directional Expressions
Pantcheva, Marina Blagoeva
2011-01-01
In my thesis, I investigate directional expressions cross-linguistically. I examine the morpho-syntactic structure of expressions of Goal (to the house), Source (from the house), Route (through the house), non-transitional paths (towards the house) and, finally, delimited paths (up to the house). I conclude that all these types of directional expressions are of different syntactic complexity. Precisely, Source expressions (from) are formed on the basis of Goal expressions (to) and Route expr...
Dynamic Shortest Path Monitoring in Spatial Networks
Shuo Shang; Lisi Chen; Zhe-Wei Wei; Dan-Huai Guo; Ji-Rong Wen
2016-01-01
With the increasing availability of real-time traﬃc information, dynamic spatial networks are pervasive nowa-days and path planning in dynamic spatial networks becomes an important issue. In this light, we propose and investigate a novel problem of dynamically monitoring shortest paths in spatial networks (DSPM query). When a traveler aims to a des-tination, his/her shortest path to the destination may change due to two reasons: 1) the travel costs of some edges have been updated and 2) the traveler deviates from the pre-planned path. Our target is to accelerate the shortest path computing in dynamic spatial networks, and we believe that this study may be useful in many mobile applications, such as route planning and recommendation, car navigation and tracking, and location-based services in general. This problem is challenging due to two reasons: 1) how to maintain and reuse the existing computation results to accelerate the following computations, and 2) how to prune the search space effectively. To overcome these challenges, filter-and-refinement paradigm is adopted. We maintain an expansion tree and define a pair of upper and lower bounds to prune the search space. A series of optimization techniques are developed to accelerate the shortest path computing. The performance of the developed methods is studied in extensive experiments based on real spatial data.
*-Regular Leavitt Path Algebras of Arbitrary Graphs
Gonzalo ARANDA PINO; Kulumani RANGASWAMY; Lia VA(S)
2012-01-01
If K is a field with involution and E an arbitrary graph,the involution from K naturally induces an involution of the Leavitt path algebra LK(E).We show that the involution on LK(E) is proper if the involution on K is positive-definite,even in the case when the graph E is not necessarily finite or row-finite.It has been shown that the Leavitt path algebra LK(E) is regular if and only if E is acyclic.We give necessary and sufficient conditions for LK(E) to be *-regular (i.e.,regular with proper involution).This characterization of *-regularity of a Leavitt path algebra is given in terms of an algebraic property of K,not just a graph-theoretic property of E.This differs from the.known characterizations of various other algebraic properties of a Leavitt path algebra in terms of graphtheoretic properties of E alone.As a corollary,we show that Handelman's conjecture (stating that every *-regular ring is unit-regular) holds for Leavitt path algebras.Moreover,its generalized version for rings with local units also continues to hold for Leavitt path algebras over arbitrary graphs.
Intelligent Online Path Planning for UAVs in Adversarial Environments
Xingguang Peng
2012-03-01
Full Text Available Online path planning (OPP for unmanned aerial vehicles (UAVs is a basic issue of intelligent flight and is indeed a dynamic multi‐objective optimization problem (DMOP. In this paper, an OPP framework is proposed in the sense of model predictive control (MPC to continuously update the environmental information for the planner. For solving the DMOP involved in the MPC we propose a dynamic multi‐objective evolutionary algorithm based on linkage and prediction (LP‐DMOEA. Within this algorithm, the historical Pareto sets are collected and analysed to enhance the performance. For intelligently selecting the best path from the output of the OPP, the Bayesian network and fuzzy logic are used to quantify the bias to each optimization objective. The DMOEA is validated on three benchmark problems characterized by different changing types in decision and objective spaces. Moreover, the simulation results show that the LP‐DMOEA overcomes the restart method for OPP. The decision‐making method for solution selection can assess the situation in an adversarial environment and accordingly adapt the path planner.
Benchmarking Gas Path Diagnostic Methods: A Public Approach
Simon, Donald L.; Bird, Jeff; Davison, Craig; Volponi, Al; Iverson, R. Eugene
2008-01-01
Recent technology reviews have identified the need for objective assessments of engine health management (EHM) technology. The need is two-fold: technology developers require relevant data and problems to design and validate new algorithms and techniques while engine system integrators and operators need practical tools to direct development and then evaluate the effectiveness of proposed solutions. This paper presents a publicly available gas path diagnostic benchmark problem that has been developed by the Propulsion and Power Systems Panel of The Technical Cooperation Program (TTCP) to help address these needs. The problem is coded in MATLAB (The MathWorks, Inc.) and coupled with a non-linear turbofan engine simulation to produce "snap-shot" measurements, with relevant noise levels, as if collected from a fleet of engines over their lifetime of use. Each engine within the fleet will experience unique operating and deterioration profiles, and may encounter randomly occurring relevant gas path faults including sensor, actuator and component faults. The challenge to the EHM community is to develop gas path diagnostic algorithms to reliably perform fault detection and isolation. An example solution to the benchmark problem is provided along with associated evaluation metrics. A plan is presented to disseminate this benchmark problem to the engine health management technical community and invite technology solutions.
Human-machine teaming for effective estimation and path planning
McCourt, Michael J.; Mehta, Siddhartha S.; Doucette, Emily A.; Curtis, J. Willard
2016-05-01
While traditional sensors provide accurate measurements of quantifiable information, humans provide better qualitative information and holistic assessments. Sensor fusion approaches that team humans and machines can take advantage of the benefits provided by each while mitigating the shortcomings. These two sensor sources can be fused together using Bayesian fusion, which assumes that there is a method of generating a probabilistic representation of the sensor measurement. This general framework of fusing estimates can also be applied to joint human-machine decision making. In the simple case, binary decisions can be fused by using a probability of taking an action versus inaction from each decision-making source. These are fused together to arrive at a final probability of taking an action, which would be taken if above a specified threshold. In the case of path planning, rather than binary decisions being fused, complex decisions can be fused by allowing the human and machine to interact with each other. For example, the human can draw a suggested path while the machine planning algorithm can refine it to avoid obstacles and remain dynamically feasible. Similarly, the human can revise a suggested path to achieve secondary goals not encoded in the algorithm such as avoiding dangerous areas in the environment.
Survival paths through the forest
Mogensen, Ulla Brasch
in appropriate prevention programs it is important to assess the individual risk with high accuracy. Generally, genetic information plays an important role for many diseases and will help to improve the accuracy of existing risk prediction models. However, conventional regression models have several limitations....... In survival analysis with competing risks I present an extension of random forest using time-dependent pseudo-values to build event risk prediction models. This approach is evaluated with data from Copenhagen stroke study. Further, I will explain how to use the R-package "pec" to evaluate random forests using...
Parallel path planning in unknown terrains
Prassler, Erwin A.; Milios, Evangelos E.
1991-03-01
We present a parallel processing approach to path planning in unknown terrains which combines map-based and sensor-based techniques into a real-time capable navigation system. The method is based on massively parallel computations in a grid of simple processing elements denoted as cells. In the course of a relaxation process a potential distribution is created in the grid which exhibits a monotonous slope from a start cell to the cell corresponding to the robot''s goal position. A shortest path is determined by means of a gradient descent criterion which settles on the steepest descent in the potential distribution. Like high-level path planning algorithms our approach is capable of planning shortest paths through an arbitrarily cluttered large-scale terrain on the basis of its current internal map. Sequentially implemented its complexity is in the order of efficient classical path planning algorithms. Unlike these algorithms however the method is also highly responsive to new obstacles encountered in the terrain. By continuing the planning process during the robot''s locomotion information about previously unknown obstacles immediately affects further path planning without a need to interrupt the ongoing planning process. New obstacles cause distortions of the potential distribution which let the robot find proper detours. By ensuring a monotonous slope in the overall distribution we avoid local minimum effects which may trap a robot in the proximity of an obstacle configuration before it has reached its goal. 1 Until the recent past research on path planning in the presence of obstacles can be assigned to two major categories: map-based high-level planning approaches and sensor-based low-level conLrol approaches. In work such as 12 path planning is treated as a high-level planning task. Assuming that an (accnrae) precompiled map of the terrain is available high-level path planners provide paths which guarantee a collision-free locomotion through an arbitrary
Reliability Analysis of Random Vibration Transmission Path Systems
Wei Zhao
2017-01-01
Full Text Available The vibration transmission path systems are generally composed of the vibration source, the vibration transfer path, and the vibration receiving structure. The transfer path is the medium of the vibration transmission. Moreover, the randomness of transfer path influences the transfer reliability greatly. In this paper, based on the matrix calculus, the generalized second moment technique, and the stochastic finite element theory, the effective approach for the transfer reliability of vibration transfer path systems was provided. The transfer reliability of vibration transfer path system with uncertain path parameters including path mass and path stiffness was analyzed theoretically and computed numerically, and the correlated mathematical expressions were derived. Thus, it provides the theoretical foundation for the dynamic design of vibration systems in practical project, so that most random path parameters can be considered to solve the random problems for vibration transfer path systems, which can avoid the system resonance failure.
Comparison of flux measurement by open-path and close-path eddy covariance systems
SONG; Xia; YU; Guirui; LIU; Yunfen; SUN; Xiaomin; REN; Chua
2005-01-01
For flux measurement, the eddy covariance technique supplies a possibility to directly measure the exchange between vegetation and atmosphere; and there are two kinds of eddy covariance systems, open-path and close-path systems. For the system error, it may result in difference of flux measurements by two systems. Therefore, it is necessary to compare the measured results from them. ChinaFLUX covers of eight sites applied the micrometeorological method, in which Changbai Mountains (CBS) and Qianyanzhou (QYZ) carried out open-path eddy covariance (OPEC) and close-path eddy covariance (CPEC) measurements synchronously.In this paper the data sets of CBS and QYZ were employed. The delay time of close-path analyzer to the open-path analyzer was calculated; the spectra and cospectra of time-series data of OPEC and CPEC were analyzed; the open-path flux measurement was used as a standard comparison, the close-path flux measurement results were evaluated. The results show that, at two sites the delay time of CO2 density for close-path analyzer was about 7.0-8.0 s, H2O density about 8.0-9.0 s; the spectrum from the open-path, close-path and 3D sonic anemometer was consistent with the expected -2/3 slope (log-log plot), and the cospectra showed the expected slope of -4/3 in the internal subrange; the CO2 flux measured by the close-path sensor was about 84% of that of open-path measurement at QYZ, about 80% at CBS, and the latent heat flux was balanced for two systems at QYZ, 86% at CBS. From the flux difference between open-path and close-path analyzers, it could be inferred that the attenuation of turbulent fluctuations in flow through tube of CPEC affected H2O flux more significantly than CO2 flux. The gap between two systems was bigger at CBS than at QYZ; the diurnal variation in CO2 flux of two measurement systems was very consistent.
Distance comparisons in virtual reality: effects of path, context, and age
Ineke eVan Der Ham
2015-08-01
Full Text Available In this large scale, individual differences study (N=521, the effects of cardinal axes of an environment and the path taken between locations on distance comparisons were assessed. The main goal was to identify if and to what extent previous findings in simple 2D tasks can be generalized to a more dynamic, three-dimensional virtual reality environment. Moreover, effects of age and gender were assessed. After memorizing the locations of six objects in a circular environment, participants were asked to judge the distance between objects they encountered. Results indicate that categorization (based on the cardinal axes was present, as distances within one quadrant were judged as being closer together, even when no visual indication of the cardinal axes was given. Moreover, strong effects of the path taken between object locations were found; objects that were near on the path taken were perceived as being closer together than objects that were further apart on this path, regardless of the metric distance between the objects. Males outperformed females in distance comparison, but did not differ in the extent of the categorization and path effects. Age also affected performance; the categorization and path effects were highly similar across the age range tested, but the general ability to estimate distances does show a clear pattern increase during development and decrease with aging.
SHP: Smooth Hypocycloidal Paths with Collision-Free and Decoupled Multi-Robot Path Planning
Abhijeet Ravankar
2016-06-01
Full Text Available Generating smooth and continuous paths for robots with collision avoidance, which avoid sharp turns, is an important problem in the context of autonomous robot navigation. This paper presents novel smooth hypocycloidal paths (SHP for robot motion. It is integrated with collision-free and decoupled multi-robot path planning. An SHP diffuses (i.e., moves points along segments the points of sharp turns in the global path of the map into nodes, which are used to generate smooth hypocycloidal curves that maintain a safe clearance in relation to the obstacles. These nodes are also used as safe points of retreat to avoid collision with other robots. The novel contributions of this work are as follows: (1 The proposed work is the first use of hypocycloid geometry to produce smooth and continuous paths for robot motion. A mathematical analysis of SHP generation in various scenarios is discussed. (2 The proposed work is also the first to consider the case of smooth and collision-free path generation for a load carrying robot. (3 Traditionally, path smoothing and collision avoidance have been addressed as separate problems. This work proposes integrated and decoupled collision-free multi-robot path planning. ‵Node caching‵ is proposed to improve efficiency. A decoupled approach with local communication enables the paths of robots to be dynamically changed. (4 A novel ‵multi-robot map update‵ in case of dynamic obstacles in the map is proposed, such that robots update other robots about the positions of dynamic obstacles in the map. A timestamp feature ensures that all the robots have the most updated map. Comparison between SHP and other path smoothing techniques and experimental results in real environments confirm that SHP can generate smooth paths for robots and avoid collision with other robots through local communication.
Cellular proliferation and hypusine synthesis.
Torrelio, B M; Paz, M A; Gallop, P M
1984-10-01
Hypusine (N(-)-(4-amino-2-hydroxybutyl) lysine), a spermidine-dependent post-translational protein modification, is synthesized by various mammalian cells in culture. Experiments described in this paper demonstrated a relationship between rates of cellular growth and the synthesis of hypusine. Cells that divide at fast rates have a high rate of hypusine synthesis. In kinetic experiments, a positive relationship is evident between the rates of protein, DNA and hypusine synthesis. Cells seeded at high density, growing non-exponentially, synthesized less hypusine than logarithmically growing cells seeded at low density. Slowing the growth rate of cells by modification of the external milieu also results in a decreased rate of hypusine synthesis. These results provide additional evidence of the association of hypusine with cell proliferation in cultured cell lines and suggest a possible role for this unusual post-translational modification in the complex macromolecular events leading to cellular growth.
Proliferation resistance fuel cycle technology
Lee, J. S.; Ko, W. I
1999-02-01
The issues of dual use in nuclear technology are analysed for nuclear fuel cycle with special focus on uranium enrichment and spent fuel reprocessing which are considered as the most sensitive components in terms of vulnerability to diversion. Technical alternatives to mitigrate the vulnerability, as has been analysed in depth during the NASAP and INFCE era in the late seventies, are reviewed to characterize the DUPIC fuel cycle alternative. On the other hand, the new realities in nuclear energy including the disposition of weapon materials as a legacy of cold war are recast in an angle of nuclear proliferation resistance and safeguards with a discussion on the concept of spent fuel standard concept and its compliance with the DUPIC fuel cycle technology. (author)
Path Integral Techniques in Conformal Field Theory
Van Tonder, A J
2004-01-01
We present the theory of a two-dimensional conformal scalar field using path integral techniques. We derive the conformal anomaly using an adaptation of the method of Fujikawa, and compare the result with a derivation based on a Pauli-Villars measure, where the anomaly is shifted from the path integral measure to the energy-momentum trace. In the path integral approach the energy-momentum is a true coordinate-invariant tensor quantity, and we explain how it is related to the corresponding non-tensor object arising in the operator approach, obtaining an intuitive explanation within the context of the path integral approach for the anomalous transformation law and anomalous Ward identities of the latter. After carefully calculating nontrivial contact terms arising in certain energy-momentum products, we use these to provide a simple consistency check confirming the change of variables formula for the path integral and to review the relationship between the conformal anomaly and the energy-momentum two-point fun...
Accurate free energy calculation along optimized paths.
Chen, Changjun; Xiao, Yi
2010-05-01
The path-based methods of free energy calculation, such as thermodynamic integration and free energy perturbation, are simple in theory, but difficult in practice because in most cases smooth paths do not exist, especially for large molecules. In this article, we present a novel method to build the transition path of a peptide. We use harmonic potentials to restrain its nonhydrogen atom dihedrals in the initial state and set the equilibrium angles of the potentials as those in the final state. Through a series of steps of geometrical optimization, we can construct a smooth and short path from the initial state to the final state. This path can be used to calculate free energy difference. To validate this method, we apply it to a small 10-ALA peptide and find that the calculated free energy changes in helix-helix and helix-hairpin transitions are both self-convergent and cross-convergent. We also calculate the free energy differences between different stable states of beta-hairpin trpzip2, and the results show that this method is more efficient than the conventional molecular dynamics method in accurate free energy calculation.
Proliferation resistance: issues, initiatives and evaluation
Pilat, Joseph F [Los Alamos National Laboratory
2009-01-01
The vision of a nuclear renaissance has highlighted the issue of proliferation resistance. The prospects for a dramatic growth in nuclear power may depend on the effectiveness of, and the resources devoted to, plans to develop and implement technologies and approaches that strengthen proliferation resistance. The GenIV International Forum (GIF) and others have devoted attention and resources to proliferation resistance. However, the hope of finding a way to make the peaceful uses of nuclear energy resistant to proliferation has reappeared again and again in the history of nuclear power with little practical consequence. The concept of proliferation resistance has usually focused on intrinsic (technological) as opposed to extrinsic (institutional) factors. However, if there are benefits that may yet be realized from reactors and other facilities designed to minimize proliferation risks, it is their coupling with effective safeguards and other nonproliferation measures that likely will be critical. Proliferation resistance has also traditionally been applied only to state threats. Although there are no technologies that can wholly eliminate the risk of proliferation by a determined state, technology can play a limited role in reducing state threats and perhaps in eliminating many non-state threats. These and other issues are not academic. They affect efforts to evaluate proliferation resistance, including the methodology developed by GIF's Proliferation Resistance and Physical Protection (PR&PP) Working Group as well as the proliferation resistance initiatives that are being pursued or may be developed in the future. This paper will offer a new framework for thinking about proliferation resistance issues, including the ways the output of the methodology could be developed to inform the decisions that states, the International Atomic Energy (IAEA) and others will have to make in order to fully realize the promise of a nuclear renaissance.
Default Path and Dedicated Path: A New Approach to Realize IP Directly Over WDM
无
2000-01-01
Combining IP and WDM is an attractive direction for research. Instead the point to point linking method, this paper proposes a new approach to realize IP directly over WDM, called DPDP (default path and dedicated path), presents a conceivable architecture in detail and explains its working procedure. A lot of problems related with this design are also discussed.
14 CFR 23.61 - Takeoff flight path.
2010-01-01
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Takeoff flight path. 23.61 Section 23.61... flight path. For each commuter category airplane, the takeoff flight path must be determined as follows: (a) The takeoff flight path begins 35 feet above the takeoff surface at the end of the...
Path Analysis: A Link between Family Theory and Reseach.
Rank, Mark R.; Sabatelli, Ronald M.
This paper discusses path analysis and the applicability of this methodology to the field of family studies. The statistical assumptions made in path analysis are presented along with a description of the two types of models within path analysis, i.e., recursive and non-recursive. Methods of calculating in the path model and the advantages of…
Stealth-Based Path Planning using Corridor Maps
Geraerts, R.J.|info:eu-repo/dai/nl/304830291; Schager, E.
2010-01-01
A relatively new area within the field of path planning deals with computing a stealthy path for a character moving in a virtual environment. Besides efficiently obtaining a path that is collision-free, short and smooth, the added difficulty is that the path must have little or no exposure to observ
An Adaptive Path Planning Algorithm for Cooperating Unmanned Air Vehicles
Cunningham, C.T.; Roberts, R.S.
2000-09-12
An adaptive path planning algorithm is presented for cooperating Unmanned Air Vehicles (UAVs) that are used to deploy and operate land-based sensor networks. The algorithm employs a global cost function to generate paths for the UAVs, and adapts the paths to exceptions that might occur. Examples are provided of the paths and adaptation.
Zhang, Jihong; Yang, Yajuan; He, Tingting; Liu, Yunqing; Zhou, Yun; Chen, Yongkang; Xu, Cunshuan
2014-09-01
Erythropoietin (EPO) has a beneficial effect on hepatic cell proliferation during liver regeneration. However, the underlying mechanism has not yet been elucidated. To uncover the proliferation response of EPO in rat liver regeneration after partial hepatectomy (PH) at the cellular level, hepatocytes (HCs) were isolated using Percoll density gradient centrifugation. The genes of the EPO-mediated signaling pathway and the target genes of the transcription factor (TF) in the pathway were identified in a pathway and TF database search. Their expression profiles were then detected using Rat Genome 230 2.0 Microarray. The results indicated that the EPO-mediated signaling pathway is involved in 19 paths and that 124 genes participate, of which 32 showed significant changes and could be identified as liver regeneration-related genes. In addition, 443 targets regulated by the TFs of the pathway and 60 genes associated with cell proliferation were contained in the array. Subsequently, the synergetic effect of these genes in liver regeneration was analyzed using the E(t) mathematical model based on their expression profiles. The results demonstrated that the E(t) values of paths 3, 8, 12 and 14-17 were significantly strengthened in the progressing phase of liver regeneration through the RAS/MEK/ERK or PI3K/AκT pathways. The synergetic effect of the target genes, in parallel with target-related cell proliferation, was also enhanced 12-72 h after PH, suggesting a potential positive effect of EPO on HC proliferation during rat liver regeneration. These data imply that the EPO receptor may allow EPO to promote HC proliferation through paths 3, 8, 12 and 14-17, mediating the RAS/MEK/ERK and PI3K/AκT pathways in rat liver regeneration after PH.
Offer and demand: proliferation and survival of neurons in the dentate gyrus.
Lehmann, Konrad; Butz, Markus; Teuchert-Noodt, Gertraud
2005-06-01
The proliferation and survival of new cells in the dentate gyrus of mammals is a complex process that is subject to numerous influences, presenting a confusing picture. We suggest regarding these processes on the level of small networks, which can be simulated in silico and which illustrate in a nutshell the influences that proliferating cells exert on plasticity and the conditions they require for survival. Beyond the insights gained by this consideration, we review the available literature on factors that regulate cell proliferation and neurogenesis in the dentate gyrus in vivo. It turns out that the rate of cell proliferation and excitatory afferents via the perforant path interactively determine cell survival, such that the best network stability is achieved when either of the two is increased whereas concurrent activation of the two factors lowers cell survival rates. Consequently, the mitotic activity is regulated by systemic parameters in compliance with the hippocampal network's requirements. The resulting neurogenesis, in contrast, depends on local factors, i.e. the activity flow within the network. In the process of cell differentiation and survival, each cell's spectrum of afferent and efferent connections decides whether it will integrate into the network or undergo apoptosis, and it is the current neuronal activity which determines the synaptic spectrum. We believe that this framework will help explain the biology of dentate cell proliferation and provide a basis for future research hypotheses.
Self-calibrating common-path interferometry.
Porras-Aguilar, Rosario; Falaggis, Konstantinos; Ramirez-San-Juan, Julio C; Ramos-Garcia, Ruben
2015-02-09
A quantitative phase measuring technique is presented that estimates the object phase from a series of phase shifted interferograms that are obtained in a common-path configuration with unknown phase shifts. The derived random phase shifting algorithm for common-path interferometers is based on the Generalized Phase Contrast theory [pl. Opt.40(2), 268 (2001)10.1063/1.1404846], which accounts for the particular image formation and includes effects that are not present in two-beam interferometry. It is shown experimentally that this technique can be used within common-path configurations employing nonlinear liquid crystal materials as self-induced phase filters for quantitative phase imaging without the need of phase shift calibrations. The advantages of such liquid crystal elements compared to spatial light modulator based solutions are given by the cost-effectiveness, self-alignment, and the generation of diminutive dimensions of the phase filter size, giving unique performance advantages.
Approximate shortest homotopic paths in weighted regions
Cheng, Siuwing
2012-02-01
A path P between two points s and t in a polygonal subdivision T with obstacles and weighted regions defines a class of paths that can be deformed to P without passing over any obstacle. We present the first algorithm that, given P and a relative error tolerance ε (0, 1), computes a path from this class with cost at most 1 + ε times the optimum. The running time is O(h 3/ε 2kn polylog (k,n,1/ε)), where k is the number of segments in P and h and n are the numbers of obstacles and vertices in T, respectively. The constant in the running time of our algorithm depends on some geometric parameters and the ratio of the maximum region weight to the minimum region weight. © 2012 World Scientific Publishing Company.
Approximate Shortest Homotopic Paths in Weighted Regions
Cheng, Siu-Wing
2010-01-01
Let P be a path between two points s and t in a polygonal subdivision T with obstacles and weighted regions. Given a relative error tolerance ε ∈(0,1), we present the first algorithm to compute a path between s and t that can be deformed to P without passing over any obstacle and the path cost is within a factor 1 + ε of the optimum. The running time is O(h 3/ε2 kn polylog(k, n, 1/ε)), where k is the number of segments in P and h and n are the numbers of obstacles and vertices in T, respectively. The constant in the running time of our algorithm depends on some geometric parameters and the ratio of the maximum region weight to the minimum region weight. © 2010 Springer-Verlag.
Quickest Paths for Different Network Router Mechanisms
Rao, N.S.V.; Grimmell, W.C.; Radhakrishnan, S.; Bang, Y.C.
2000-06-01
The quickest path problem deals with the transmission of a message of size {sigma} from a source to a destination with the minimum end-to-end delay over a network with bandwidth and delay constraints on the links. The authors consider four basic modes and two variations for the message delivery at the nodes reflecting the mechanisms such as circuit switching, Internet protocol, and their combinations. For each of the first three modes, they present O(m{sup 2} + mn log n) time algorithm to compute the quickest path for a given message size {sigma}. For the last mode, the quickest path can be computed in O(m + n log n) time.
Quickest Paths in Simulations of Pedestrians
Kretz, Tobias; Hengst, Stefan; Kautzsch, Lukas; Pohlmann, Andrej; Vortisch, Peter
2011-01-01
This contribution proposes a method to make agents in a microscopic simulation of pedestrian traffic walk approximately along a path of estimated minimal remaining travel time to their destination. Usually models of pedestrian dynamics are (implicitly) built on the assumption that pedestrians walk along the shortest path. Model elements formulated to make pedestrians locally avoid collisions and intrusion into personal space do not produce motion on quickest paths. Therefore a special model element is needed, if one wants to model and simulate pedestrians for whom travel time matters most (e.g. travelers in a station hall who are late for a train). Here such a model element is proposed, discussed and used within the Social Force Model.
The thorny path linking cellular senescence to organismalaging
Patil, Christopher K.; Mian, Saira; Campisi, Judith
2005-08-09
Half a century is fast approaching since Hayflick and colleagues formally described the limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961). This finding--that normal somatic cells, in contrast to cancer cells, cannot divide indefinitely--challenged the prevailing idea that cells from mortal multicellular organisms were intrinsically ''immortal'' (Carrell, 1912). It also spawned two hypotheses, essential elements of which persist today. The first held that the restricted proliferation of normal cells, now termed cellular senescence, suppresses cancer (Hayflick, 1965; Sager, 1991; Campisi, 2001). The second hypothesis, as explained in the article by Lorenzini et al., suggested that the limited proliferation of cells in culture recapitulated aspects of organismal aging (Hayflick, 1965; Martin, 1993). How well have these hypotheses weathered the ensuing decades? Before answering this question, we first consider current insights into the causes and consequences of cellular senescence. Like Lorenzini et al., we limit our discussion to mammals. We also focus on fibroblasts, the cell type studied by Lorenzini et al., but consider other types as well. We suggest that replicative capacity in culture is not a straightforward assessment, and that it correlates poorly with both longevity and body mass. We speculate this is due to the malleable and variable nature of replicative capacity, which renders it an indirect metric of qualitative and quantitative differences among cells to undergo senescence, a response that directly alters cellular phenotype and might indirectly alter tissue structure and function.
Tornado intensity estimated from damage path dimensions.
Elsner, James B; Jagger, Thomas H; Elsner, Ian J
2014-01-01
The Newcastle/Moore and El Reno tornadoes of May 2013 are recent reminders of the destructive power of tornadoes. A direct estimate of a tornado's power is difficult and dangerous to get. An indirect estimate on a categorical scale is available from a post-storm survery of the damage. Wind speed bounds are attached to the scale, but the scale is not adequate for analyzing trends in tornado intensity separate from trends in tornado frequency. Here tornado intensity on a continuum is estimated from damage path length and width, which are measured on continuous scales and correlated to the EF rating. The wind speeds on the EF scale are treated as interval censored data and regressed onto the path dimensions and fatalities. The regression model indicates a 25% increase in expected intensity over a threshold intensity of 29 m s(-1) for a 100 km increase in path length and a 17% increase in expected intensity for a one km increase in path width. The model shows a 43% increase in the expected intensity when fatalities are observed controlling for path dimensions. The estimated wind speeds correlate at a level of .77 (.34, .93) [95% confidence interval] with a small sample of wind speeds estimated independently from a doppler radar calibration. The estimated wind speeds allow analyses to be done on the tornado database that are not possible with the categorical scale. The modeled intensities can be used in climatology and in environmental and engineering applications. Research is needed to understand the upward trends in path length and width.
Robust paths to realize nonadiabatic holonomic gates
Xu, G. F.; Zhao, P. Z.; Tong, D. M.; Sjöqvist, Erik
2017-05-01
To realize one desired nonadiabatic holonomic gate, various equivalent evolution paths can be chosen. However, in the presence of errors, these paths become inequivalent. In this paper we investigate the difference of these evolution paths in the presence of systematic Rabi-frequency errors and aim to find paths with optimal robustness to realize one-qubit nonadiabatic holonomic gates. We focus on three types of evolution paths in the Λ system: paths belonging to the original two-loop scheme [E. Sjöqvist et al., New J. Phys. 14, 103035 (2012), 10.1088/1367-2630/14/10/103035], the single-loop multiple-pulse scheme [E. Herterich and E. Sjöqvist, Phys. Rev. A 94, 052310 (2016), 10.1103/PhysRevA.94.052310], and the off-resonance single-shot scheme [G. F. Xu et al., Phys. Rev. Lett. 92, 052302 (2015), 10.1103/PhysRevLett.92.052302; E. Sjöqvist, Phys. Lett. A 380, 65 (2016), 10.1016/j.physleta.2015.10.006]. Whereas both the single-loop multiple-pulse and single-shot schemes aim to improve the robustness of the original two-loop scheme by shortening the exposure to decoherence, we find here that the two-loop scheme is more robust to systematic errors in the Rabi frequencies. More importantly, we derive conditions under which the resilience to this kind of error can be optimized, thereby strengthening the robustness of nonadiabatic holonomic gates.
Quantum cosmology based on discrete Feynman paths
Chew, Geoffrey F.
2002-10-10
Although the rules for interpreting local quantum theory imply discretization of process, Lorentz covariance is usually regarded as precluding time quantization. Nevertheless a time-discretized quantum representation of redshifting spatially-homogeneous universe may be based on discrete-step Feynman paths carrying causal Lorentz-invariant action--paths that not only propagate the wave function but provide a phenomenologically-promising elementary-particle Hilbert-space basis. In a model under development, local path steps are at Planck scale while, at a much larger ''wave-function scale'', global steps separate successive wave-functions. Wave-function spacetime is but a tiny fraction of path spacetime. Electromagnetic and gravitational actions are ''at a distance'' in Wheeler-Feynman sense while strong (color) and weak (isospin) actions, as well as action of particle motion, are ''local'' in a sense paralleling the action of local field theory. ''Nonmaterial'' path segments and ''trivial events'' collaborate to define energy and gravity. Photons coupled to conserved electric charge enjoy privileged model status among elementary fermions and vector bosons. Although real path parameters provide no immediate meaning for ''measurement'', the phase of the complex wave function allows significance for ''information'' accumulated through ''gentle'' electromagnetic events involving charged matter and ''soft'' photons. Through its soft-photon content the wave function is an ''information reservoir''.
Serotonin regulates osteoblast proliferation and function in vitro
Dai, S.Q.; Yu, L.P. [Department of Orthopedic Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu (China); Shi, X. [Department of Obstetrics and Gynecology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu (China); Wu, H. [Emergency Department, The First Affiliated Hospital, Soochow University, Suzhou (China); Shao, P.; Yin, G.Y.; Wei, Y.Z. [Department of Orthopedic Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu (China)
2014-08-01
The monoamine serotonin (5-hydroxytryptamine, 5-HT), a well-known neurotransmitter, also has important functions outside the central nervous system. The objective of this study was to investigate the role of 5-HT in the proliferation, differentiation, and function of osteoblasts in vitro. We treated rat primary calvarial osteoblasts with various concentrations of 5-HT (1 nM to 10 µM) and assessed the rate of osteoblast proliferation, expression levels of osteoblast-specific proteins and genes, and the ability to form mineralized nodules. Next, we detected which 5-HT receptor subtypes were expressed in rat osteoblasts at different stages of osteoblast differentiation. We found that 5-HT could inhibit osteoblast proliferation, differentiation, and mineralization at low concentrations, but this inhibitory effect was mitigated at relatively high concentrations. Six of the 5-HT receptor subtypes (5-HT{sub 1A}, 5-HT{sub 1B}, 5-HT{sub 1D}, 5-HT{sub 2A}, 5-HT{sub 2B}, and 5-HT{sub 2C}) were found to exist in rat osteoblasts. Of these, 5-HT{sub 2A} and 5-HT{sub 1B} receptors had the highest expression levels, at both early and late stages of differentiation. Our results indicated that 5-HT can regulate osteoblast proliferation and function in vitro.
Histamine inhibits adrenocortical cell proliferation but does not affect steroidogenesis.
Pagotto, Romina Maria; Pereyra, Elba Nora; Monzón, Casandra; Mondillo, Carolina; Pignataro, Omar Pedro
2014-04-01
Histamine (HA) is a neurotransmitter synthesized in most mammalian tissues exclusively by histidine decarboxylase enzyme. Among the plethora of actions mediated by HA, the modulatory effects on steroidogenesis and proliferation in Leydig cells (LCs) have been described recently. To determine whether the effects on LCs reported could be extrapolated to all steroidogenic systems, in this study, we assessed the effect of this amine on adrenal proliferation and steroidogenesis, using two adrenocortical cell lines as experimental models, murine Y1 cells and human NCI-H295R cells. Even when steroidogenesis was not modified by HA in adrenocortical cells, the biogenic amine inhibited the proliferation of H295R cells. This action was mediated by the activation of HRH1 subtype and an increase in the production of inositol phosphates as second messengers, causing cell-cycle arrest in the G2/M phase. These results indicate a new role for HA in the proliferation of human adrenocortical cells that could contribute to a better understanding of tumor pathology as well as to the development of new therapeutic agents.
Effect of Leptin on Cytotrophoblast Proliferation and Invasion
Haiyi LIU; Yuanyuan WU; Fuyuan QIAO; Xun GONG
2009-01-01
The effects of leptin on cytotrophoblast proliferation and invasion activity were investigated.Immunohistochemistry was used to determine the placental expression of leptin in first-trimester preg-nancy. By using RT-PCR and quantitative real-time PCR, the expression of leptin in cytotrophoblast and the effect of leptin on cytotrophoblast secretion were detected. The potential of cell proliferation, inva-siveness and migration was assessed by MTT, Transwell invasion assay and migration assay respec-tively when the cytotrophoblast was cultured with different concentrations of leptin. The results showed that: (1) Leptin was distributed diffusely around cell membrane, in cytoplasma, and on nuclear mem-brane of cytotrophoblast; (2) Leptin mRNA was expressed in cytotrophoblast. Ten ng/mL leptin could promote the secretion of cytotrophoblast significantly (P<0.01); (3) After culture with different concen-trations of leptin for 24 h or longer, the proliferation of cytotrophoblast was inhibited, while in 24 h leptin could promote cytotrophoblast invasion and migration. Leptin at a concentration of 500 ng/mL could promote cytotrophoblast invasiveness and migration significantly as compared with controls (P<0.05). It was suggested that leptin could inhibit cytotrophoblast proliferation, and promote cytotro-phoblast invasion and migration activity.
Path planning for everday robotics with SANDROS
Watterberg, P.; Xavier, P. [Sandia National Labs., Albuquerque, NM (United States); Hwang, Y. [Korea Inst. of Science and Technology, Seoul (Korea, Republic of)
1997-02-01
We discuss the integration of the SANDROS path planner into a general robot simulation and control package with the inclusion of a fast geometry engine for distance calculations. This creates a single system that allows the path to be computed, simulated, and then executed on the physical robot. The architecture and usage procedures are presented. Also, we present examples of its usage in typical environments found in our organization. The resulting system is as easy to use as the general simulation system (which is in common use here) and is fast enough (example problems are solved in seconds) to be used interactively on an everyday basis.
Airway Tree Extraction with Locally Optimal Paths
Lo, Pechin Chien Pau; Sporring, Jon; Pedersen, Jesper Johannes Holst
2009-01-01
This paper proposes a method to extract the airway tree from CT images by continually extending the tree with locally optimal paths. This is in contrast to commonly used region growing based approaches that only search the space of the immediate neighbors. The result is a much more robust method...... for tree extraction that can overcome local occlusions. The cost function for obtaining the optimal paths takes into account of an airway probability map as well as measures of airway shape and orientation derived from multi-scale Hessian eigen analysis on the airway probability. Significant improvements...
Field theory a path integral approach
Das, Ashok
2006-01-01
This unique book describes quantum field theory completely within the context of path integrals. With its utility in a variety of fields in physics, the subject matter is primarily developed within the context of quantum mechanics before going into specialized areas.Adding new material keenly requested by readers, this second edition is an important expansion of the popular first edition. Two extra chapters cover path integral quantization of gauge theories and anomalies, and a new section extends the supersymmetry chapter, where singular potentials in supersymmetric systems are described.
Determinants of Box Products of Paths
Pragel, Daniel
2011-01-01
Suppose that G is the graph obtained by taking the box product of a path of length n and a path of length m. Let M be the adjacency matrix of G. If n=m, H.M. Rara showed in 1996 that det(M)=0. We extend this result to allow n and m to be any positive integers, and show that, if gcd(n+1,m+1)>1, then det(M)=0; otherwise, if gcd(n+1,m+1)=1, then det(M)=(-1)^(nm/2).
Vessel tree extraction using locally optimal paths
Lo, Pechin Chien Pau; van Ginneken, Bram; de Bruijne, Marleen
2010-01-01
This paper proposes a method to extract vessel trees by continually extending detected branches with locally optimal paths. Our approach uses a cost function from a multi scale vessel enhancement filter. Optimal paths are selected based on rules that take into account the geometric characteristics...... of the vessel tree. Experiments were performed on 10 low dose chest CT scans for which the pulmonary vessel trees were extracted. The proposed method is shown to extract a better connected vessel tree and extract more of the small peripheral vessels in comparison to applying a threshold on the output...
Stability Analysis of Path-vector Routing
Dimitri, Papadimitriou
2012-01-01
Most studies on path-vector routing stability have been conducted empirically by means of ad-hoc analysis of BGP data traces. None of them consider prior specification of an analytic method including the use of stability measurement metrics for the systematic analysis of BGP traces and associated meta-processing for determining the local state of the routing system. In this paper, we define a set of metrics that characterize the local stability properties of path-vector routing such as BGP (Border Gateway Protocol). By means of these stability metrics, we propose a method to analyze the effects of BGP policy- and protocol-induced instability on local routers.
Analysis of Path-vector Routing Stability
Dimitri, Papadimitriou
2012-01-01
Most studies on path-vector routing stability have been conducted empirically by means of ad-hoc analysis of BGP data traces. None of them consider prior specification of an analytic method including the use of stability measurement metrics for the systematic analysis of BGP traces and associated meta-processing for determining the local state of the routing system. In this paper, we define a set of metrics that characterize the local stability properties of path-vector routing such as BGP (Border Gateway Protocol). By means of these stability metrics, we propose a method to analyze the effects of BGP policy- and protocol-induced instability on local routers.
Gas Path Sealing in Turbine Engines
Ludwig, L. P.
1978-01-01
A survey of gas path seals is presented with particular attention given to sealing clearance effects on engine component efficiency. The effects on compressor pressure ratio and stall margin are pointed out. Various case-rotor relative displacements, which affect gas path seal clearances, are identified. Forces produced by nonuniform sealing clearances and their effect on rotor stability are discussed qualitatively, and recent work on turbine-blade-tip sealing for high temperature is described. The need for active clearance control and for engine structural analysis is discussed. The functions of the internal-flow system and its seals are reviewed.
Flight Path Recovery System (FPRS) design study
1978-09-01
The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented.
Samuel Alpha Kamara
2015-09-01
Full Text Available Among other things, So the Path Does Not Die rekindles age-old themes such as tradition versus change; ethnicity, racism, sexism, and marginal identities; individual and institutional corruption; Diaspora and home; love and sacrifice; civil war and rehabilitation with fresh insights and focus. This article examines these themes in the novel's treatment of Talaba culture and its Musudugu myth.
Survey of Robot 3D Path Planning Algorithms
Liang Yang; Juntong Qi; Dalei Song; Jizhong Xiao; Jianda Han; Yong Xia
2016-01-01
Robot 3D (three-dimension) path planning targets for finding an optimal and collision-free path in a 3D workspace while taking into account kinematic constraints (including geometric, physical, and temporal constraints). The purpose of path planning, unlike motion planning which must be taken into consideration of dynamics, is to find a kinematically optimal path with the least time as well as model the environment completely. We discuss the fundamentals of these most successful robot 3D path...
Success of Path Dependence Through Perpetuation of Failure During Reform
E Kasabov
2010-01-01
The primary purpose of this paper is to extend current debates about path dependence and to contribute to scholarship by addressing inadequately researched aspects of path dependence: the role of individuals in sustaining long-standing 'inefficient' institutions; the balance of 'path following' and 'path violation'; and path dependent resource utilisation, not resource allocation. These matters are illustrated through and discussed in the context of 'asset-stripping' and 'rent-seeking' in the...
Proliferation after the Iraq war; La proliferation apres la guerre d'Irak
Daguzan, J.F
2004-09-15
This article uses the Iraq war major event to analyze the approach used by the US to fight against proliferation. It questions the decision and analysis process which has led to the US-British intervention and analyzes the consequences of the war on the proliferation of other countries and on the expected perspectives. Finally, the future of proliferation itself is questioned: do we have to fear more threat or is the virtuous circle of non-proliferation well started? (J.S.)
Kristi M Porter
Full Text Available Pulmonary Hypertension (PH is a progressive disorder characterized by endothelial dysfunction and proliferation. Hypoxia induces PH by increasing vascular remodeling. A potential mediator in hypoxia-induced PH development is arachidonate 5-Lipoxygenase (ALOX5. While ALOX5 metabolites have been shown to promote pulmonary vasoconstriction and endothelial cell proliferation, the contribution of ALOX5 to hypoxia-induced proliferation remains unknown. We hypothesize that hypoxia exposure stimulates HPAEC proliferation by increasing ALOX5 expression and activity. To test this, human pulmonary artery endothelial cells (HPAEC were cultured under normoxic (21% O2 or hypoxic (1% O2 conditions for 24-, 48-, or 72 hours. In a subset of cells, the ALOX5 inhibitor, zileuton, or the 5-lipoxygenase activating protein inhibitor, MK-886, was administered during hypoxia exposure. ALOX5 expression was measured by qRT-PCR and western blot and HPAEC proliferation was assessed. Our results demonstrate that 24 and 48 hours of hypoxia exposure have no effect on HPAEC proliferation or ALOX5 expression. Seventy two hours of hypoxia significantly increases HPAEC ALOX5 expression, hydrogen peroxide (H2O2 release, and HPAEC proliferation. We also demonstrate that targeted ALOX5 gene silencing or inhibition of the ALOX5 pathway by pharmacological blockade attenuates hypoxia-induced HPAEC proliferation. Furthermore, our findings indicate that hypoxia-induced increases in cell proliferation and ALOX5 expression are dependent on H2O2 production, as administration of the antioxidant PEG-catalase blocks these effects and addition of H2O2 to HPAEC promotes proliferation. Overall, these studies indicate that hypoxia exposure induces HPAEC proliferation by activating the ALOX5 pathway via the generation of H2O2.
Control of cell proliferation by Myc
Bouchard, C; Staller, P; Eilers, M
1998-01-01
Myc proteins are key regulators of mammalian cell proliferation. They are transcription factors that activate genes as part of a heterodimeric complex with the protein Max. This review summarizes recent progress in understanding how Myc stimulates cell proliferation and how this might contribute...
Corneal cellular proliferation and wound healing
Gan, Lisha
2000-01-01
Background. Cellular proliferation plays an important role in both physiological and pathological processes. Epithelial hyperplasia in the epithelium, excessive scar formation in retrocorneal membrane formation and neovascularization are examples of excessive proliferation of cornea cells. Lack of proliferative ability causes corneal degeneration. The degree of proliferative and metabolic activity will directly influence corneal transparency and very evidently refractive res...
Teaching Activities on Horizontal Nuclear Proliferation.
Zola, John
1990-01-01
Provides learning activities concerning the horizontal proliferation of nuclear weapons. Includes step-by-step directions for four activities: (1) the life cycle of nuclear weapons; (2) nuclear nonproliferation: pros and cons; (3) the nuclear power/nuclear weapons connection; and (4) managing nuclear proliferation. (NL)
Nuclear Proliferation as a Global Values Issue.
Nelson, Jack L.
1990-01-01
Presents a classroom activity designed to involve students in critical thinking and values inquiry concerning the horizontal nuclear proliferation. Provides a set of global values, explaining the conflict between them and nuclear proliferation. Uses indicators, hypothesis development, and testing. Provides sources for material evidence to use in…
Director`s series on proliferation
Bailey, K.C.; Price, M.E. [eds.
1995-11-17
This is an occasional publication of essays on the topics of nuclear, chemical, biological, and missile proliferation. The views represented are those of the author`s. Essay topics include: Nuclear Proliferation: Myth and Reality; Problems of Enforcing Compliance with Arms Control Agreements; The Unreliability of the Russian Officer Corps: Reluctant Domestic Warriors; and Russia`s Nuclear Legacy.
Director`s series on proliferation
Bailey, K.C.; Price, M.E. [eds.
1995-11-17
This is an occasional publication of essays on the topics of nuclear, chemical, biological, and missile proliferation. The views represented are those of the author`s. Essay topics include: Nuclear Proliferation: Myth and Reality; Problems of Enforcing Compliance with Arms Control Agreements; The Unreliability of the Russian Officer Corps: Reluctant Domestic Warriors; and Russia`s Nuclear Legacy.
The endocannabinoid system drives neural progenitor proliferation.
Aguado, Tania; Monory, Krisztina; Palazuelos, Javier; Stella, Nephi; Cravatt, Benjamin; Lutz, Beat; Marsicano, Giovanni; Kokaia, Zaal; Guzmán, Manuel; Galve-Roperh, Ismael
2005-10-01
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of marijuana-derived cannabinoids, act as neuromodulators via presynaptic CB1 receptors and also control neural cell death and survival. Here we show that progenitor cells express a functional endocannabinoid system that actively regulates cell proliferation both in vitro and in vivo. Specifically, NPs produce endocannabinoids and express the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase (FAAH). CB1 receptor activation promotes cell proliferation and neurosphere generation, an action that is abrogated in CB1-deficient NPs. Accordingly, proliferation of hippocampal NPs is increased in FAAH-deficient mice. Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain.
FLIGHT PATH CONTROL FOR UNMANNED AERIAL VEHICLE
M. A. Al-Mashhadani
2014-01-01
Full Text Available Studying the optimized control law specified criteria on UAV while hovering over a path defined by the reference points in the inertial frame. An illustrative example is the theoretical efficiency of the proposed provisions.
Stochastic Evolutionary Algorithms for Planning Robot Paths
Fink, Wolfgang; Aghazarian, Hrand; Huntsberger, Terrance; Terrile, Richard
2006-01-01
A computer program implements stochastic evolutionary algorithms for planning and optimizing collision-free paths for robots and their jointed limbs. Stochastic evolutionary algorithms can be made to produce acceptably close approximations to exact, optimal solutions for path-planning problems while often demanding much less computation than do exhaustive-search and deterministic inverse-kinematics algorithms that have been used previously for this purpose. Hence, the present software is better suited for application aboard robots having limited computing capabilities (see figure). The stochastic aspect lies in the use of simulated annealing to (1) prevent trapping of an optimization algorithm in local minima of an energy-like error measure by which the fitness of a trial solution is evaluated while (2) ensuring that the entire multidimensional configuration and parameter space of the path-planning problem is sampled efficiently with respect to both robot joint angles and computation time. Simulated annealing is an established technique for avoiding local minima in multidimensional optimization problems, but has not, until now, been applied to planning collision-free robot paths by use of low-power computers.
Path Planning in a Dynamic Environment
Mohamed EL KHAILI
2014-08-01
Full Text Available Path planning is an important area in the control of autonomous mobile robots. Recent work has focused on aspects reductions in processing time than the memory requirements. A dynamic environment uses a lot of memory and hence the processing time increases too. Our approach is to reduce the processing time by the use of a pictorial approach to reduce the number of data used. In this paper, we present a path planning approach that operates in three steps. First, a construction of the visibility tree is performed. The following treatments are not performed on the original image but on the result tree whose elements are specific points of the environment linked by the relationship of visibility. We construct thereafter a visibility graph which one seeks the shortest path. This approach has a great interest because of its fast execution speed. The path search is extended also for the case where obstacles can move. The moving obstacles may be other mobile robots whose trajectories and speeds are known initially. At the end, some applications are provided on solving similar problem such civil aviation in order to guide plane avoiding collisions.
Predictors of Retirement Satisfaction: A Path Model.
Kremer, Yael
1985-01-01
Examined adjustment to retirement among 310 former industrial and service workers. Respondents had come to terms with retirement and enjoyed their more relaxed lifestyle. Dominant variables in the path model were retirees' satisfaction with specific aspects of retirement: giving up work, activities with family and friends, rest, and free time. (BH)
Learning paths and OER: trends and opportunities
Janssen, José; Berlanga, Adriana; Koper, Rob
2013-01-01
Janssen, J., Berlanga, A. J., & Koper, R. (2013). Learning paths and OER: trends and opportunities. In R. Jacobi, H. Jelgerhuis, & N. van der Woert (Eds.), Trendreport Open Educational Resources 2013 (pp. 76-80). Utrecht: SURF Foundation - Special Interest Group Open Educational Resources SURF. Fina
Demixing light paths inside disordered metamaterials
Vellekoop, Ivo Micha; van Putten, E.G.; Putten, E.G.; Lagendijk, Aart; Mosk, Allard
2008-01-01
We experimentally demonstrate the first method to focus light inside disordered photonic metamaterials. In such materials, scattering prevents light from forming a geometric focus. Instead of geometric optics, we used multi-path interference to make the scattering process itself concentrate light on
Bead-Fourier path integral molecular dynamics
Ivanov, Sergei D.; Lyubartsev, Alexander P.; Laaksonen, Aatto
2003-06-01
Molecular dynamics formulation of Bead-Fourier path integral method for simulation of quantum systems at finite temperatures is presented. Within this scheme, both the bead coordinates and Fourier coefficients, defining the path representing the quantum particle, are treated as generalized coordinates with corresponding generalized momenta and masses. Introduction of the Fourier harmonics together with the center-of-mass thermostating scheme is shown to remove the ergodicity problem, known to pose serious difficulties in standard path integral molecular dynamics simulations. The method is tested for quantum harmonic oscillator and hydrogen atom (Coulombic potential). The simulation results are compared with the exact analytical solutions available for both these systems. Convergence of the results with respect to the number of beads and Fourier harmonics is analyzed. It was shown that addition of a few Fourier harmonics already improves the simulation results substantially, even for a relatively small number of beads. The proposed Bead-Fourier path integral molecular dynamics is a reliable and efficient alternative to simulations of quantum systems.
Unified classical path theories of pressure broadening.
Bottcher, C.
1971-01-01
Derivation of a unified classical path theory of pressure broadening, using only elementary concepts. It is shown that the theory of Smith, Cooper and Vidal (1969) is only correct at all frequencies to first order in the number density of perturbers.
Path-breaking books in regional science
Waldorf, BS
2004-01-01
This article presents a collection of regional science books that long-standing members of the Regional Science Association International (RSAI) identified as path-breaking books. The most frequently nominated books include the "classics" by Isard, the seminal books in urban economics by Alonso, Mut
Transition paths in molecules at finite temperature
Pinski, F. J.; Stuart, A. M.
2010-05-01
In the zero temperature limit, it is well known that in systems evolving via Brownian dynamics, the most likely transition path between reactant and product may be found as a minimizer of the Freidlin-Wentzell action functional. An analog for finite temperature transitions is given by the Onsager-Machlup functional. The purpose of this work is to investigate properties of Onsager-Machlup minimizers. We study transition paths for thermally activated molecules governed by the Langevin equation in the overdamped limit of Brownian dynamics. Using gradient descent in pathspace, we minimize the Onsager-Machlup functional for a range of model problems in one and two dimensions and then for some simple atomic models including Lennard-Jones seven-atom and 38-atom clusters, as well as for a model of vacancy diffusion in a planar crystal. Our results demonstrate interesting effects, which can occur at nonzero temperature, showing transition paths that could not be predicted on the basis of the zero temperature limit. However the results also demonstrate unphysical features associated with such Onsager-Machlup minimizers. As there is a growing literature that addresses transition path sampling by related techniques, these insights add a potentially useful perspective into the interpretation of this body of work.
Star-Paths, Stones and Horizon Astronomy
Brady, Bernadette
2015-05-01
Archaeoastronomers tend to approach ancient monuments focusing on the landscape and the horizon calendar events of sun and moon and, due to problems with precession, generally ignore the movement of the stars. However, locating the position of solar calendar points on the horizon can have other uses apart from calendar and/or cosmological purposes. This paper firstly suggests that the stars do not need to be ignored. By considering the evidence of the Phaenomena, a sky poem by Aratus of Soli, a third century BC Greek poet, and his use of second millennium BC star lore fragments, this paper argues that the stars were a part of the knowledge of horizon astronomy. Aratus' poem implied that the horizon astronomy of the late Neolithic and Bronze Age periods included knowledge of star-paths or 'linear constellations' that were defined by particular horizon calendar events and other azimuths. Knowledge of such star-paths would have enabled navigation and orientation, and by using permanent markers, constructed or natural, to define these paths, they were immune to precession as the stones could redefine a star-path for a future generation. Finally the paper presents other possible intentions behind the diverse orientation of passage tombs and some megalithic sites.
Demixing light paths inside disordered metamaterials
Vellekoop, I.M.; Putten, E.G.; Lagendijk, A.; Mosk, A.P.
2008-01-01
We experimentally demonstrate the first method to focus light inside disordered photonic metamaterials. In such materials, scattering prevents light from forming a geometric focus. Instead of geometric optics, we used multi-path interference to make the scattering process itself concentrate light on
Damage detection using frequency shift path
Wang, Longqi; Lie, Seng Tjhen; Zhang, Yao
2016-01-01
This paper introduces a novel concept called FREquency Shift (FRESH) path to describe the dynamic behavior of structures with auxiliary mass. FRESH path combines the effects of frequency shifting and amplitude changing into one space curve, providing a tool for analyzing structure health status and properties. A damage index called FRESH curvature is then proposed to detect local stiffness reduction. FRESH curvature can be easily adapted for a particular problem since the sensitivity of the index can be adjusted by changing auxiliary mass or excitation power. An algorithm is proposed to adjust automatically the contribution from frequency and amplitude in the method. Because the extraction of FRESH path requires highly accurate frequency and amplitude estimators; therefore, a procedure based on discrete time Fourier transform is introduced to extract accurate frequency and amplitude with the time complexity of O (n log n), which is verified by simulation signals. Moreover, numerical examples with different damage sizes, severities and damping are presented to demonstrate the validity of the proposed damage index. In addition, applications of FRESH path on two steel beams with different damages are presented and the results show that the proposed method is valid and computational efficient.
Quad-rotor flight path energy optimization
Kemper, Edward
Quad-Rotor unmanned areal vehicles (UAVs) have been a popular area of research and development in the last decade, especially with the advent of affordable microcontrollers like the MSP 430 and the Raspberry Pi. Path-Energy Optimization is an area that is well developed for linear systems. In this thesis, this idea of path-energy optimization is extended to the nonlinear model of the Quad-rotor UAV. The classical optimization technique is adapted to the nonlinear model that is derived for the problem at hand, coming up with a set of partial differential equations and boundary value conditions to solve these equations. Then, different techniques to implement energy optimization algorithms are tested using simulations in Python. First, a purely nonlinear approach is used. This method is shown to be computationally intensive, with no practical solution available in a reasonable amount of time. Second, heuristic techniques to minimize the energy of the flight path are tested, using Ziegler-Nichols' proportional integral derivative (PID) controller tuning technique. Finally, a brute force look-up table based PID controller is used. Simulation results of the heuristic method show that both reliable control of the system and path-energy optimization are achieved in a reasonable amount of time.
Path-breaking books in regional science
Waldorf, BS
2004-01-01
This article presents a collection of regional science books that long-standing members of the Regional Science Association International (RSAI) identified as path-breaking books. The most frequently nominated books include the "classics" by Isard, the seminal books in urban economics by Alonso, Mut
Path-breaking books in regional science
Waldorf, BS
This article presents a collection of regional science books that long-standing members of the Regional Science Association International (RSAI) identified as path-breaking books. The most frequently nominated books include the "classics" by Isard, the seminal books in urban economics by Alonso,
A path following algorithm for mobile robots
Bakker, T.; Asselt, van C.J.; Bontsema, J.; Müller, J.; Straten, van G.
2010-01-01
This paper considers path following control for a robotic platform. The vehicle used for the experiments is a specially designed robotic platform for performing autonomous weed control. The platform is four-wheel steered and four-wheel driven. A diesel engine powers the wheels via a hydraulic transm
Cutting Path Planning for Ruled Surface Impellers
Liang Quan; Wang Yongzhang; Fu Hongya; Han Zhenyu
2008-01-01
At present, most commercial computer-aided manufacturing (CAM) systems are deficient in efficiency and performances on generating tool path during machining impellers. To solve the problem, this article develops a special software to plan cutting path for ruled surface impellers. An approximation algorithm to generate cutting path for machining integral ruled surface impellers is proposed. By fitting sampling data points of an impeller blade into a curve, a model of ruled surface blade of an impeller is built up. Furthermore, by calculating the points where the cutter axis vector intersects the flee-form hub surface of an impeller, problems about, for instance, the ambiguity in calculation and machining the wide blade surface with a short flute cutter are solved. Finally, an integral impeller cutting path is planned by way of an integrated cutter location control algorithm. Simulation and machining tests with an impeller are performed on a 5-axis computer numerically controlled (CNC) mill machine, which shows the feasibility of the proposed algorithm.
Contracting Graphs to Paths and Trees
Heggernes, Pinar; Lévêque, Benjamin; Lokshtanov, Daniel; Paul, Christophe
2011-01-01
Vertex deletion and edge deletion problems play a central role in Parameterized Complexity. Examples include classical problems like Feedback Vertex Set, Odd Cycle Transversal, and Chordal Deletion. Interestingly, the study of edge contraction problems of this type from a parameterized perspective has so far been left largely unexplored. We consider two basic edge contraction problems, which we call Path-Contractibility and Tree-Contractibility. Both problems take an undirected graph $G$ and an integer $k$ as input, and the task is to determine whether we can obtain a path or an acyclic graph, respectively, by contracting at most $k$ edges of $G$. Our main contribution is an algorithm with running time $4^{k+O(\\log^2 k)} + n^{O(1)}$ for Path-Contractibility and an algorithm with running time $4.88^k n^{O(1)}$ for Tree-Contractibility, based on a novel application of the color coding technique of Alon, Yuster and Zwick. Furthermore, we show that Path-Contractibility has a kernel with at most $5k+3$ vertices, w...
Current Algebra in the Path Integral framework
Cardenas, V H; Saavedra, J
1998-01-01
In this letter we describe an approach to the current algebra based in the Path Integral formalism. We use this method for abelian and non-abelian quantum field theories in 1+1 and 2+1 dimensions and the correct expressions are obtained. Our results show the independence of the regularization of the current algebras.
2010-01-01
... height equal to its wing span. (e) For airplanes equipped with standby power rocket engines, the takeoff... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Takeoff path. 25.111 Section 25.111 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT...
Global Cloud Liquid Water Path Simulations(.
Lemus, Lilia; Rikus, Lawrie; Martin, C.; Platt, R.
1997-01-01
A new parameterization of cloud liquid water and ice content has been included in the Bureau of Meteorology Global Assimilation and Prediction System. The cloud liquid water content is derived from the mean cloud temperatures in the model using an empirical relationship based on observations. The results from perpetual January and July simulations are presented and show that the total cloud water path steadily decreases toward high latitudes, with two relative maxima at midlatitudes and a peak at low latitudes. To validate the scheme, the simulated fields need to be processed to produce liquid water paths that can be directly compared with the corresponding field derived from Special Sensor Microwave/Imager (SSM/I) data. This requires the identification of cloud ice water content within the parameterization and a prescription to account for the treatment of strongly precipitating subgrid-scale cloud. The resultant cloud liquid water paths agree qualitatively with the SSM/I data but show some systematic errors that are attributed to corresponding errors in the model's simulation of cloud amounts. Given that a more quantitative validation requires substantial improvement in the model's diagnostic cloud scheme, the comparison with the SSM/I data indicates that the cloud water path, derived from the cloud liquid water content parameterization introduced in this paper, is consistent with the observations and can be usefully incorporated in the prediction system.
Learning to improve path planning performance
Chen, Pang C.
1995-04-01
In robotics, path planning refers to finding a short. collision-free path from an initial robot configuration to a desired configuratioin. It has to be fast to support real-time task-level robot programming. Unfortunately, current planning techniques are still too slow to be effective, as they often require several minutes, if not hours of computation. To remedy this situation, we present and analyze a learning algorithm that uses past experience to increase future performance. The algorithm relies on an existing path planner to provide solutions to difficult tasks. From these solutions, an evolving sparse network of useful robot configurations is learned to support faster planning. More generally, the algorithm provides a speedup-learning framework in which a slow but capable planner may be improved both cost-wise and capability-wise by a faster but less capable planner coupled with experience. The basic algorithm is suitable for stationary environments, and can be extended to accommodate changing environments with on-demand experience repair and object-attached experience abstraction. To analyze the algorithm, we characterize the situations in which the adaptive planner is useful, provide quantitative bounds to predict its behavior, and confirm our theoretical results with experiments in path planning of manipulators. Our algorithm and analysis are sufficiently, general that they may also be applied to other planning domains in which experience is useful.
A path following algorithm for mobile robots
Bakker, T.; Asselt, van C.J.; Bontsema, J.; Müller, J.; Straten, van G.
2010-01-01
This paper considers path following control for a robotic platform. The vehicle used for the experiments is a specially designed robotic platform for performing autonomous weed control. The platform is four-wheel steered and four-wheel driven. A diesel engine powers the wheels via a hydraulic
Path integration in tactile perception of shapes.
Moscatelli, Alessandro; Naceri, Abdeldjallil; Ernst, Marc O
2014-11-01
Whenever we move the hand across a surface, tactile signals provide information about the relative velocity between the skin and the surface. If the system were able to integrate the tactile velocity information over time, cutaneous touch may provide an estimate of the relative displacement between the hand and the surface. Here, we asked whether humans are able to form a reliable representation of the motion path from tactile cues only, integrating motion information over time. In order to address this issue, we conducted three experiments using tactile motion and asked participants (1) to estimate the length of a simulated triangle, (2) to reproduce the shape of a simulated triangular path, and (3) to estimate the angle between two-line segments. Participants were able to accurately indicate the length of the path, whereas the perceived direction was affected by a direction bias (inward bias). The response pattern was thus qualitatively similar to the ones reported in classical path integration studies involving locomotion. However, we explain the directional biases as the result of a tactile motion aftereffect.
Preliminary analysis of alternative fuel cycles for proliferation evaluation
Steindler, M. J.; Ripfel, H. C.F.; Rainey, R. H.
1977-01-01
The ERDA Division of Nuclear Research and Applications proposed 67 nuclear fuel cycles for assessment as to their nonproliferation potential. The object of the assessment was to determine which fuel cycles pose inherently low risk for nuclear weapon proliferation while retaining the major benefits of nuclear energy. This report is a preliminary analysis of these fuel cycles to develop the fuel-recycle data that will complement reactor data, environmental data, and political considerations, which must be included in the overall evaluation. This report presents the preliminary evaluations from ANL, HEDL, ORNL, and SRL and is the basis for a continuing in-depth study. (DLC)
ENHANCING ADVANCED CANDU PROLIFERATION RESISTANCE FUEL WITH MINOR ACTINIDES
Gray S. Chang
2010-05-01
The advanced nuclear system will significantly advance the science and technology of nuclear energy systems and to enhance the spent fuel proliferation resistance. Minor actinides (MA) are viewed more as a resource to be recycled, and transmuted to less hazardous and possibly more useful forms, rather than simply disposed of as a waste stream in an expensive repository facility. MAs can play a much larger part in the design of advanced systems and fuel cycles, not only as additional sources of useful energy, but also as direct contributors to the reactivity control of the systems into which they are incorporated. In this work, an Advanced CANDU Reactor (ACR) fuel unit lattice cell model with 43 UO2 fuel rods will be used to investigate the effectiveness of a Minor Actinide Reduction Approach (MARA) for enhancing proliferation resistance and improving the fuel cycle performance. The main MARA objective is to increase the 238Pu / Pu isotope ratio by using the transuranic nuclides (237Np and 241Am) in the high burnup fuel and thereby increase the proliferation resistance even for a very low fuel burnup. As a result, MARA is a very effective approach to enhance the proliferation resistance for the on power refueling ACR system nuclear fuel. The MA transmutation characteristics at different MA loadings were compared and their impact on neutronics criticality assessed. The concept of MARA, significantly increases the 238Pu/Pu ratio for proliferation resistance, as well as serves as a burnable absorber to hold-down the initial excess reactivity. It is believed that MARA can play an important role in atoms for peace and the intermediate term of nuclear energy reconnaissance.
Global path planning of mobile robots using a memetic algorithm
Zhu, Zexuan; Wang, Fangxiao; He, Shan; Sun, Yiwen
2015-08-01
In this paper, a memetic algorithm for global path planning (MAGPP) of mobile robots is proposed. MAGPP is a synergy of genetic algorithm (GA) based global path planning and a local path refinement. Particularly, candidate path solutions are represented as GA individuals and evolved with evolutionary operators. In each GA generation, the local path refinement is applied to the GA individuals to rectify and improve the paths encoded. MAGPP is characterised by a flexible path encoding scheme, which is introduced to encode the obstacles bypassed by a path. Both path length and smoothness are considered as fitness evaluation criteria. MAGPP is tested on simulated maps and compared with other counterpart algorithms. The experimental results demonstrate the efficiency of MAGPP and it is shown to obtain better solutions than the other compared algorithms.
Guo-Hua Ma; Xue-Lin Huang; Bunn Eric
2006-01-01
We report the vegetative proliferation and new phenomenon of "secondary proliferated inflorescences" in the grass Ischaemum barbatum Retz, as determined by anatomical analysis of prepared sections of inflorescences. Leaves and shoots could be developed from the original spikelets of inflorescences and plantlets developed when these shoots were transplanted to moist soil. "Secondary proliferated inflorescences" is the first name here because some inflorescences that developed inadequacy are grown from the spikelet on the mother inflorescence. Our investigation showed that this form of vegetative proliferation and secondary proliferated inflorescences development of I. barbatum has arisen following late autumn fires of the previous year. It is suggested that the sudden onset of a fire could lead to a hormone imbalance or a chemical induction, which results in ephemeral vegetative proliferation even secondary proliferated inflorescences development in wild populations.
De Lillo, Carlo; Kirby, Melissa; Poole, Daniel
2016-01-01
Immediate serial spatial recall measures the ability to retain sequences of locations in short-term memory and is considered the spatial equivalent of digit span. It is tested by requiring participants to reproduce sequences of movements performed by an experimenter or displayed on a monitor. Different organizational factors dramatically affect serial spatial recall but they are often confounded or underspecified. Untangling them is crucial for the characterization of working-memory models and for establishing the contribution of structure and memory capacity to spatial span. We report five experiments assessing the relative role and independence of factors that have been reported in the literature. Experiment 1 disentangled the effects of spatial clustering and path-length by manipulating the distance of items displayed on a touchscreen monitor. Long-path sequences segregated by spatial clusters were compared with short-path sequences not segregated by clusters. Recall was more accurate for sequences segregated by clusters independently from path-length. Experiment 2 featured conditions where temporal pauses were introduced between or within cluster boundaries during the presentation of sequences with the same paths. Thus, the temporal structure of the sequences was either consistent or inconsistent with a hierarchical representation based on segmentation by spatial clusters but the effect of structure could not be confounded with effects of path-characteristics. Pauses at cluster boundaries yielded more accurate recall, as predicted by a hierarchical model. In Experiment 3, the systematic manipulation of sequence structure, path-length, and presence of path-crossings of sequences showed that structure explained most of the variance, followed by the presence/absence of path-crossings, and path-length. Experiments 4 and 5 replicated the results of the previous experiments in immersive virtual reality navigation tasks where the viewpoint of the observer changed
Carlo De Lillo
2016-11-01
Full Text Available Immediate serial spatial recall measures the ability to retain sequences of locations in short-term memory and is considered the spatial equivalent of digit span. It is tested by requiring participants to reproduce sequences of movements performed by an experimenter or displayed on a monitor. Different organizational factors dramatically affect serial spatial recall but they are often confounded or underspecified. Untangling them is crucial for the characterization of working-memory models and for establishing the contribution of structure and memory capacity to spatial span. We report five experiments assessing the relative role and independence of factors that have been reported in the literature. Experiment 1 disentangled the effects of spatial clustering and path-length by manipulating the distance of items displayed on a touchscreen monitor. Long-path sequences segregated by spatial clusters were compared with short-path sequences not segregated by clusters. Recall was more accurate for sequences segregated by clusters independently from path-length. Experiment 2 featured conditions where temporal pauses were introduced between or within cluster boundaries during the presentation of sequences with the same paths. Thus, the temporal structure of the sequences was either consistent or inconsistent with a hierarchical representation based on segmentation by spatial clusters but the effect of structure could not be confounded with effects of path-characteristics. Pauses at cluster boundaries yielded more accurate recall, as predicted by a hierarchical model. In Experiment 3, the systematic manipulation of sequence structure, path-length and presence of path-crossings of sequences showed that structure explained most of the variance, followed by the presence/absence of path-crossings, and path-length. Experiments 4 and 5 replicated the results of the previous experiments in immersive virtual reality navigation tasks where the viewpoint of the
Ethanol inhibits human bone cell proliferation and function in vitro
Friday, K.E.; Howard, G.A. (University of Washington, Seattle (USA))
1991-06-01
The direct effects of ethanol on human bone cell proliferation and function were studied in vitro. Normal human osteoblasts from trabecular bone chips were prepared by collagenase digestion. Exposure of these osteoblasts to ethanol in concentrations of 0.05% to 1% for 22 hours induced a dose-dependent reduction in bone cell DNA synthesis as assessed by incorporation of 3H-thymidine. After 72 hours of ethanol exposure in concentrations of 0.01% to 1%, protein synthesis as measured by 3H-proline incorporation into trichbroacetic acid (TCA)-precipitable material was reduced in a dose-dependent manner. Human bone cell protein concentrations and alkaline phosphatase total activity were significantly reduced after exposure to 1% ethanol for 72 hours, but not with lower concentrations of ethanol. This reduction in osteoblast proliferation and activity may partially explain the development of osteopenia in humans consuming excessive amounts of ethanol.
Interference factors regarding the path of insertion of rotational-path removable partial dentures
Chan-Te Huang; Fang-Chun Liu; Kwing-Chi Luk
2017-01-01
Background: The aims of this study were to evaluate the effect of the location of the rotational center and the morphology of teeth resulting in interference with the rotational path of insertion and to estimate...
A Path Space Extension for Robust Light Transport Simulation
Hachisuka, Toshiya; Pantaleoni, Jacopo; Jensen, Henrik Wann
2012-01-01
We present a new sampling space for light transport paths that makes it possible to describe Monte Carlo path integration and photon density estimation in the same framework. A key contribution of our paper is the introduction of vertex perturbations, which extends the space of paths with loosely...... coupled connections. The new framework enables the computation of path probabilities in the same space under the same measure, which allows us to use multiple importance sampling to combine Monte Carlo path integration and photon density estimation. The resulting algorithm, unified path sampling, can...
Strained tetragonal states and Bain paths in metals
Alippi, P; Scheffler, M
1996-01-01
Paths of tetragonal states between two phases of a material, such as bcc and fcc, are called Bain paths. Two simple Bain paths can be defined in terms of special imposed stresses, one of which applies directly to strained epitaxial films. Each path goes far into the range of nonlinear elasticity and reaches a range of structural parameters in which the structure is inherently unstable. In this paper we identify and analyze the general properties of these paths by density functional theory. Special examples include vanadium, cobalt and copper, and the epitaxial path is used to identify an epitaxial film as related uniquely to a bulk phase.
Harmine stimulates proliferation of human neural progenitors
Dakic, Vanja; Maciel, Renata de Moraes; Drummond, Hannah; Nascimento, Juliana M.; Trindade, Pablo
2016-01-01
Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive) derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A), which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY), and an irreversible selective inhibitor of monoamine oxidase (MAO) but not DYRK1A (pargyline). INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo. PMID:27957390
Harmine stimulates proliferation of human neural progenitors
Vanja Dakic
2016-12-01
Full Text Available Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A, which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY, and an irreversible selective inhibitor of monoamine oxidase (MAO but not DYRK1A (pargyline. INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo.
Mielke, Steven L; Truhlar, Donald G
2016-01-21
Using Feynman path integrals, a molecular partition function can be written as a double integral with the inner integral involving all closed paths centered at a given molecular configuration, and the outer integral involving all possible molecular configurations. In previous work employing Monte Carlo methods to evaluate such partition functions, we presented schemes for importance sampling and stratification in the molecular configurations that constitute the path centroids, but we relied on free-particle paths for sampling the path integrals. At low temperatures, the path sampling is expensive because the paths can travel far from the centroid configuration. We now present a scheme for importance sampling of whole Feynman paths based on harmonic information from an instantaneous normal mode calculation at the centroid configuration, which we refer to as harmonically guided whole-path importance sampling (WPIS). We obtain paths conforming to our chosen importance function by rejection sampling from a distribution of free-particle paths. Sample calculations on CH4 demonstrate that at a temperature of 200 K, about 99.9% of the free-particle paths can be rejected without integration, and at 300 K, about 98% can be rejected. We also show that it is typically possible to reduce the overhead associated with the WPIS scheme by sampling the paths using a significantly lower-order path discretization than that which is needed to converge the partition function.
Transition path time distribution and the transition path free energy barrier.
Pollak, Eli
2016-10-19
The recent experimental measurement of the transition path time distributions of proteins presents several challenges to theory. Firstly, why do the fits of the experimental data to a theoretical expression lead to barrier heights which are much lower than the free energies of activation of the observed transitions? Secondly, there is the theoretical question of determining the transition path time distribution, without invoking the Smoluchowski limit. In this paper, we derive an exact expression for a transition path time distribution which is valid for arbitrary memory friction using the normal mode transformation which underlies Kramers' rate theory. We then recall that for low barriers, there is a noticeable difference between the transition path time distribution obtained with absorbing boundary conditions and free boundary conditions. For the former, the transition times are shorter, since recrossings of the boundaries are disallowed. As a result, if one uses the distribution based on absorbing boundary conditions to fit the experimental data, one will find that the transition path barrier will be larger than the values found based on a theory with free boundary conditions. We then introduce the paradigm of a transition path barrier height, and show that one should always expect it to be much smaller than the activation energy.
Financial incentives for reducing proliferation risks
Weise, Rachel A.; Hund, Gretchen
2016-08-15
This article submitted for publication to the Bulletin of Atomic Scientists explains the possible financial incentives for financial institutions and large integrators to reduce nuclear proliferation risks by including anti-proliferation measures in their due diligence and requiring their suppliers to meet heightened compliance standards. Because manufacturers of dual-use nuclear goods are diverse and numerous outreach is difficult. However, financial institutions and large integrators work with nearly all dual-use manufacturers, making financial institutions and integrators well-positioned to increase awareness of proliferation and trafficking risks throughout the nuclear supply chain
Bautista, Alfredo; Brizuela, Bárbara M.; Glennie, Corinne R.; Caddle, Mary C.
2014-01-01
Professional development (PD) programs often evaluate their impact on teachers' learning by assessing teachers either individually or in groups. The goal of this paper is to illustrate the variety of paths teachers might follow as a result of working in groups within online PD settings. Data are drawn from a PD program for grades 5-9 mathematics…
The Accreditation Process for Science: The Path Leads to Unintended (Positive) Consequences
Kubitskey, Beth; Rutherford, Sandra; Wylo, Bonnie; Liggit, Peggy
2011-01-01
In this paper, we discuss how a community of scholars came together to create assessments across science departments for the initial teacher preparation program in secondary science teaching. The steps of the process taken to meet accreditation standards are described, as well as some surprising findings from our road trip down the path of…
Global path planning approach based on ant colony optimization algorithm
WEN Zhi-qiang; CAI Zi-xing
2006-01-01
Ant colony optimization (ACO) algorithm was modified to optimize the global path. In order to simulate the real ant colonies, according to the foraging behavior of ant colonies and the characteristic of food, conceptions of neighboring area and smell area were presented. The former can ensure the diversity of paths and the latter ensures that each ant can reach the goal. Then the whole path was divided into three parts and ACO was used to search the second part path. When the three parts pathes were adjusted,the final path was found. The valid path and invalid path were defined to ensure the path valid. Finally, the strategies of the pheromone search were applied to search the optimum path. However, when only the pheromone was used to search the optimum path, ACO converges easily. In order to avoid this premature convergence, combining pheromone search and random search, a hybrid ant colony algorithm(HACO) was used to find the optimum path. The comparison between ACO and HACO shows that HACO can be used to find the shortest path.
Phosphorothioate oligodeoxyribonucleotides induce in vitro proliferation of chicken B-cells.
Wattrang, Eva
2009-10-15
The study aimed to evaluate short synthetic oligodeoxyribonucleotides (ODN) as inducers of proliferation of chicken peripheral blood mononuclear cells (PBMC) and to identify the proliferating cells. A panel of different ODN; with phosphodiester and/or phosphorothioate backbone, with and without CpG-motifs, was therefore assessed for in vitro induction of proliferation. Six complete phosphorothioate ODN induced proliferation of PBMC while the complete phosphodiester or chimeric phosphodiester/phosphorohiate ODN did not. Moreover, CpG-motifs were not essential for induction of proliferation as responses to CpG-ODN were similar to those of their GpC controls. Two stimulatory phosphorothioate ODN were also used in phosphodiester form. In this comparison, only the phosphorothioate ODN were active despite the identical nucleotide sequences of their phosphodiester counterparts. In order to deliver DNA to the cytoplasm and decrease degradation of ODN by nucleases, stimulating as well as inactive ODN were treated with lipofectin prior to induction. However, proliferative responses were not influenced by lipofectin treatment and in analogy, none of the inactive ODN induced proliferation after lipofectin treatment. Among PBMC, ODN-responding cells were identified as predominantly Bu-1, immunoglobulin and major histocompatibility complex class II expressing cells, while CD3 expressing cells were not responding. Using magnetic cell separation of Bu-1 expressing cells prior to culture it was found that Bu-1 depleted cells did not proliferate upon ODN stimulation while the Bu-1 enriched cells were able to proliferate upon this stimulus. Taken together, among ODN in the present panel, only phosphorothioate ODN induced proliferation of PBMC. Responses were induced regardless of the presence of CpG-motifs and were not influenced by addition of lipofectin. Amid the chicken PBMC, predominantly cells of a B-cell phenotype proliferated in response to ODN stimulation and they were able
Vehicle path tracking by integrated chassis control
Saman Salehpour; Yaghoub Pourasad; Seyyed Hadi Taheri
2015-01-01
The control problem of trajectory based path following for passenger vehicles is studied. Comprehensive nonlinear vehicle model is utilized for simulation vehicle response during various maneuvers in MATLAB/Simulink. In order to follow desired path, a driver model is developed to enhance closed loop driver/vehicle model. Then, linear quadratic regulator (LQR) controller is developed which regulates direct yaw moment and corrective steering angle on wheels. Particle swam optimization (PSO) method is utilized to optimize the LQR controller for various dynamic conditions. Simulation results indicate that, over various maneuvers, side slip angle and lateral acceleration can be reduced by 10%and 15%, respectively, which sustain the vehicle stable. Also, anti-lock brake system is designed for longitudinal dynamics of vehicle to achieve desired slip during braking and accelerating. Proposed comprehensive controller demonstrates that vehicle steerability can increase by about 15% during severe braking by preventing wheel from locking and reducing stopping distance.
Broadband Phase Spectroscopy over Turbulent Air Paths.
Giorgetta, Fabrizio R; Rieker, Gregory B; Baumann, Esther; Swann, William C; Sinclair, Laura C; Kofler, Jon; Coddington, Ian; Newbury, Nathan R
2015-09-01
Broadband atmospheric phase spectra are acquired with a phase-sensitive dual-frequency-comb spectrometer by implementing adaptive compensation for the strong decoherence from atmospheric turbulence. The compensation is possible due to the pistonlike behavior of turbulence across a single spatial-mode path combined with the intrinsic frequency stability and high sampling speed associated with dual-comb spectroscopy. The atmospheric phase spectrum is measured across 2 km of air at each of the 70,000 comb teeth spanning 233 cm(-1) across hundreds of near-infrared rovibrational resonances of CO(2), CH(4), and H(2)O with submilliradian uncertainty, corresponding to a 10(-13) refractive index sensitivity. Trace gas concentrations extracted directly from the phase spectrum reach 0.7 ppm uncertainty, demonstrated here for CO(2). While conventional broadband spectroscopy only measures intensity absorption, this approach enables measurement of the full complex susceptibility even in practical open path sensing.
Quantum tunneling from paths in complex time
Bramberger, Sebastian F; Lehners, Jean-Luc
2016-01-01
We study quantum mechanical tunneling using complex solutions of the classical field equations. Simple visualization techniques allow us to unify and generalize previous treatments, and straightforwardly show the connection to the standard approach using Euclidean instanton solutions. We demonstrate that the negative modes of solutions along various contours in the complex time plane reveal which paths contribute to tunneling and which do not, and we provide a criterion for identifying the negative modes. Central to our approach is the solution of the background and perturbation equations not only along a single path, but over an extended region of the complex time plane. Our approach allows for a fully continuous and coherent treatment of classical evolution interspersed by quantum tunneling events, and is applicable in situations where singularities are present and also where Euclidean solutions might not exist.
Hamiltonian formalism and path entropy maximization
Davis, Sergio; González, Diego
2015-10-01
Maximization of the path information entropy is a clear prescription for constructing models in non-equilibrium statistical mechanics. Here it is shown that, following this prescription under the assumption of arbitrary instantaneous constraints on position and velocity, a Lagrangian emerges which determines the most probable trajectory. Deviations from the probability maximum can be consistently described as slices in time by a Hamiltonian, according to a nonlinear Langevin equation and its associated Fokker-Planck equation. The connections unveiled between the maximization of path entropy and the Langevin/Fokker-Planck equations imply that missing information about the phase space coordinate never decreases in time, a purely information-theoretical version of the second law of thermodynamics. All of these results are independent of any physical assumptions, and thus valid for any generalized coordinate as a function of time, or any other parameter. This reinforces the view that the second law is a fundamental property of plausible inference.
UAV Path Planning using MILP with Experiments
Anders Albert
2017-01-01
Full Text Available In this paper, we look at the problem of tracking icebergs using multiple Unmanned Aerial Vehicles (UAVs. Our solutions use combinatorial optimization for UAV path planning by formulating a mixed integer linear programing (MILP optimization problem. To demonstrate the approach, we present both a simulation and a practical experiment. The simulation demonstrates the possibilities of the MILP algorithm by constructing a case where three UAVs help a boat make a safe passage through an area with icebergs. Furthermore, we compare the performance of three against a single UAV. In the practical experiment, we take the first step towards full-scale experiments. We run the algorithm on a ground station and use it to set the path for a UAV tracking five simulated icebergs.
Path Integral Bosonization of Massive GNO Fermions
Park, Q H
1997-01-01
We show the quantum equivalence between certain symmetric space sine-Gordon models and the massive free fermions. In the massless limit, these fermions reduce to the free fermions introduced by Goddard, Nahm and Olive (GNO) in association with symmetric spaces $K/G$. A path integral formulation is given in terms of the Wess-Zumino-Witten action where the field variable $g$ takes value in the orthogonal, unitary, and symplectic representations of the group $G$ in the basis of the symmetric space. We show that, for example, such a path integral bosonization is possible when the symmetric spaces $K/G$ are $SU(N) the relation between massive GNO fermions and the nonabelian solitons, and explain the restriction imposed on the fermion mass matrix due to the integrability of the bosonic model.
Exploiting Deterministic TPG for Path Delay Testing
李晓维
2000-01-01
Detection of path delay faults requires two-pattern tests. BIST technique provides a low-cost test solution. This paper proposes an approach to designing a cost-effective deterministic test pattern generator (TPG) for path delay testing. Given a set of pre-generated test-pairs with pre-determined fault coverage, a deterministic TPG is synthesized to apply the given test-pair set in a limited test time. To achieve this objective, configurable linear feedback shift register (LFSR) structures are used. Techniques are developed to synthesize such a TPG, which is used to generate an unordered deterministic test-pair set. The resulting TPG is very efficient in terms of hardware size and speed performance. Simulation of academic benchmark circuits has given good results when compared to alternative solutions.
Strong path convergence from Loewner driving convergence
Sheffield, Scott
2010-01-01
We show that, under mild assumptions on the limiting curve, a sequence of simple chordal planar curves converges uniformly whenever certain Loewner driving functions converge. We extend this result to random curves. The random version applies in particular to random lattice paths that have chordal SLE as a scaling limit, with kappa less than 8 (non-space-filling). Existing SLE convergence proofs often begin by showing that the Loewner driving functions of these paths (viewed from infinity) converge to Brownian motion. Unfortunately, this is not sufficient, and additional arguments are required to complete the proofs. We show that driving function convergence is sufficient if it can be established for both parametrization directions and a generic target.
Families of graph-different Hamilton paths
Körner, János; Simonyi, Gábor
2011-01-01
Let D be an arbitrary subset of the natural numbers. For every n, let M(n;D) be the maximum of the cardinality of a set of Hamiltonian paths in the complete graph K_n such that the union of any two paths from the family contains a not necessarily induced cycle of some length from D. We determine or bound the asymptotics of M(n;D) in various special cases. This problem is closely related to that of the permutation capacity of graphs and constitutes a further extension of the problem area around Shannon capacity. We also discuss how to generalize our cycle-difference problems and present an example where cycles are replaced by 4-cliques. These problems are in a natural duality to those of graph intersection, initiated by Erd\\"os, Simonovits and S\\'os. The lack of kernel structure as a natural candidate for optimum makes our problems quite challenging.
Microstructural path analysis of martensite burst
Paulo Rangel Rios
2010-03-01
Full Text Available Modeling the martensite reaction requires reckoning with spatial aspects of the reaction. For that, we used formal kinetics, more specifically, the microstructural path method (MPM to analyze the microstructure observed in a burst. The microstructural path analysis revealed that the size of the spread cluster in extended space, characterized by the Vandermeer and Juul-Jensen's impingement compensated mean intercept length, λG, remained constant, independently of the parent austenite grain size. Moreover, current analysis introduced a purely formal description of the reaction progress by taking the parent austenite grain size as the progress variable. This description worked very well and resulted in a relationship between the volume fraction of partially transformed austenite, V VG, and austenite grain size, λG. The significance of these findings in the light of the advantages and disadvantages of formal kinetics is discussed.
Quantum gravitation the Feynman path integral approach
Hamber, Herbert W
2009-01-01
The book covers the theory of Quantum Gravitation from the point of view of Feynman path integrals. These provide a manifestly covariant approach in which fundamental quantum aspects of the theory such as radiative corrections and the renormalization group can be systematically and consistently addressed. The path integral method is suitable for both perturbative as well as non-perturbative studies, and is known to already provide a framework of choice for the theoretical investigation of non-abelian gauge theories, the basis for three of the four known fundamental forces in nature. The book thus provides a coherent outline of the present status of the theory gravity based on Feynman’s formulation, with an emphasis on quantitative results. Topics are organized in such a way that the correspondence to similar methods and results in modern gauge theories becomes apparent. Covariant perturbation theory are developed using the full machinery of Feynman rules, gauge fixing, background methods and ghosts. The ren...
Quantum Measurement and Extended Feynman Path Integral
文伟; 白彦魁
2012-01-01
Quantum measurement problem has existed many years and inspired a large of literature in both physics and philosophy, but there is still no conclusion and consensus on it. We show it can be subsumed into the quantum theory if we extend the Feynman path integral by considering the relativistic effect of Feynman paths. According to this extended theory, we deduce not only the Klein-Gordon equation, but also the wave-function-collapse equation. It is shown that the stochastic and instantaneous collapse of the quantum measurement is due to the ＂potential noise＂ of the apparatus or environment and ＂inner correlation＂ of wave function respectively. Therefore, the definite-status of the macroscopic matter is due to itself and this does not disobey the quantum mechanics. This work will give a new recognition for the measurement problem.
An alternative path integral for quantum gravity
Krishnan, Chethan; Kumar, K. V. Pavan; Raju, Avinash
2016-10-01
We define a (semi-classical) path integral for gravity with Neumann boundary conditions in D dimensions, and show how to relate this new partition function to the usual picture of Euclidean quantum gravity. We also write down the action in ADM Hamiltonian formulation and use it to reproduce the entropy of black holes and cosmological horizons. A comparison between the (background-subtracted) covariant and Hamiltonian ways of semi-classically evaluating this path integral in flat space reproduces the generalized Smarr formula and the first law. This "Neumann ensemble" perspective on gravitational thermodynamics is parallel to the canonical (Dirichlet) ensemble of Gibbons-Hawking and the microcanonical approach of Brown-York.
An Alternate Path Integral for Quantum Gravity
Krishnan, Chethan; Raju, Avinash
2016-01-01
We define a (semi-classical) path integral for gravity with Neumann boundary conditions in $D$ dimensions, and show how to relate this new partition function to the usual picture of Euclidean quantum gravity. We also write down the action in ADM Hamiltonian formulation and use it to reproduce the entropy of black holes and cosmological horizons. A comparison between the (background-subtracted) covariant and Hamiltonian ways of semi-classically evaluating this path integral in flat space reproduces the generalized Smarr formula and the first law. This "Neumann ensemble" perspective on gravitational thermodynamics is parallel to the canonical (Dirichlet) ensemble of Gibbons-Hawking and the microcanonical approach of Brown-York.
An alternative path integral for quantum gravity
Krishnan, Chethan; Kumar, K.V. Pavan; Raju, Avinash [Center for High Energy Physics, Indian Institute of Science,Bangalore 560012 (India)
2016-10-10
We define a (semi-classical) path integral for gravity with Neumann boundary conditions in D dimensions, and show how to relate this new partition function to the usual picture of Euclidean quantum gravity. We also write down the action in ADM Hamiltonian formulation and use it to reproduce the entropy of black holes and cosmological horizons. A comparison between the (background-subtracted) covariant and Hamiltonian ways of semi-classically evaluating this path integral in flat space reproduces the generalized Smarr formula and the first law. This “Neumann ensemble” perspective on gravitational thermodynamics is parallel to the canonical (Dirichlet) ensemble of Gibbons-Hawking and the microcanonical approach of Brown-York.
Dominating Sets and Domination Polynomials of Paths
Saeid Alikhani
2009-01-01
Full Text Available Let G=(V,E be a simple graph. A set S⊆V is a dominating set of G, if every vertex in V\\S is adjacent to at least one vertex in S. Let 𝒫ni be the family of all dominating sets of a path Pn with cardinality i, and let d(Pn,j=|𝒫nj|. In this paper, we construct 𝒫ni, and obtain a recursive formula for d(Pn,i. Using this recursive formula, we consider the polynomial D(Pn,x=∑i=⌈n/3⌉nd(Pn,ixi, which we call domination polynomial of paths and obtain some properties of this polynomial.
Constructing Sublinear Expectations on Path Space
Nutz, Marcel
2012-01-01
We provide a general construction of time-consistent sublinear expectations on the space of continuous paths. It yields the existence of the conditional G-expectation of a Borel-measurable (rather than quasi-continuous) random variable, a generalization of the random G-expectation, and an optional sampling theorem that holds without exceptional set. Our results also shed light on the inherent limitations to constructing sublinear expectations through aggregation.
Extreme paths in oriented 2D Percolation
Andjel, E. D.; Gray, L. F.
2014-01-01
A useful result about leftmost and rightmost paths in two dimensional bond percolation is proved. This result was introduced without proof in \\cite{G} in the context of the contact process in continuous time. As discussed here, it also holds for several related models, including the discrete time contact process and two dimensional site percolation. Among the consequences are a natural monotonicity in the probability of percolation between different sites and a somewhat counter-intuitive corr...
Path integral measure for gravitational interactions
Kazuo Fujikawa
1983-10-01
Full Text Available It is pointed out that the path-integral variables as well as the local measure for gravitational interactions are uniquely specified if one imposes the anomaly-free condition on the Becchi-Rouet-Stora supersymmetry associated with general coordinate transformations. This prescription is briefly illustrated for the Einstein gravity and supergravity in four space-time dimensions and the relativistic string theory in two dimensions.
A Path Integral Approach To Noncommutative Superspace
Chepelev, I; Chepelev, Iouri; Ciocarlie, Calin
2003-01-01
A path integral formula for the associative star-product of two superfields is proposed. It is a generalization of the Kontsevich-Cattaneo-Felder's formula for the star-product of functions of bosonic coordinates. The associativity of the star-product imposes certain conditions on the background of our sigma model. For generic background the action is not supersymmetric. The supersymmetry invariance of the action constrains the background and leads to a simple formula for the star-product.
Pedestrian traffic: on the quickest path
Kretz, Tobias
2009-03-01
When a large group of pedestrians moves around a corner, most pedestrians do not follow the shortest path, which is to stay as close as possible to the inner wall, but try to minimize the travel time. For this they accept to move on a longer path with some distance to the corner, to avoid large densities and by this succeed in maintaining a comparatively high speed. In many models of pedestrian dynamics the basic rule of motion is often either 'move as far as possible toward the destination' or—reformulated—'of all coordinates accessible in this time step move to the one with the smallest distance to the destination'. On top of this rule modifications are placed to make the motion more realistic. These modifications usually focus on local behavior and neglect long-ranged effects. Compared to real pedestrians this leads to agents in a simulation valuing the shortest path a lot better than the quickest. So, in a situation such as the movement of a large crowd around a corner, one needs an additional element in a model of pedestrian dynamics that makes the agents deviate from the rule of the shortest path. In this work it is shown how this can be achieved by using a flood fill dynamic potential field method, where during the filling process the value of a field cell is not increased by 1, but by a larger value, if it is occupied by an agent. This idea may be an obvious one: however, the tricky part—and therefore in a strict sense the contribution of this work—is (a) to minimize unrealistic artifacts, as naive flood fill metrics deviate considerably from the Euclidean metric and in this respect yield large errors, (b) do this with limited computational effort and (c) keep agents' movement at very low densities unaltered.
Bloch oscillations of path-entangled photons.
Bromberg, Yaron; Lahini, Yoav; Silberberg, Yaron
2010-12-31
We show that when photons in N-particle path-entangled |N,0)+|0,N) or N00N states undergo Bloch oscillations, they exhibit a periodic transition between spatially bunched and antibunched states. The period of the bunching-antibunching oscillation is N times faster than the period of the oscillation of the photon density, manifesting the unique coherence properties of N00N states. The transition occurs even when the photons are well separated in space.
Flux Control in Networks of Diffusion Paths
A. I. Zhmoginov and N. J. Fisch
2009-07-08
A class of optimization problems in networks of intersecting diffusion domains of a special form of thin paths has been considered. The system of equations describing stationary solutions is equivalent to an electrical circuit built of intersecting conductors. The solution of an optimization problem has been obtained and extended to the analogous electrical circuit. The interest in this network arises from, among other applications, an application to wave-particle diffusion through resonant interactions in plasma.
Civil Society and Paths to Abolition
Seymour DRESCHER
2015-12-01
Full Text Available Abstract Through a comparative analysis, this article aims to present an overview of British, French, Russian, American and Brazilian abolitionist action, between the late eighteenth century and throughout the nineteenth century. Indicating the struggles of pro-abolition civil associations, the paths taken in Britain, France, the US and Brazil are presented in parallel - either to emphasize approaches, either to highlight the undeniable peculiarities - revealing the marks of violence and negotiation present in the emancipation process.
Dynamic Shortest Path Algorithms for Hypergraphs
2012-01-01
Performance comparison of algorithms for the dynamic shortest path problem,” IEICE Transactions on Fundamentals of Electronics , Communications and...computation,” IEEE/ACM Transactions on Networking, vol. 8, no. 6, pp. 734–746, 2000. [8] G. Ramalingam and T. Reps, “An incremental algorithm for a...multihop performance,” IEEE Transactions on Mobile Computing, pp. 337–348, 2003. [17] S. Chachulski, M. Jennings, S. Katti, and D. Katabli, “Trading
Path description of coordinate-space amplitudes
Erdoǧan, Ozan; Sterman, George
2017-06-01
We develop a coordinate version of light-cone-ordered perturbation theory, for general time-ordered products of fields, by carrying out integrals over one light-cone coordinate for each interaction vertex. The resulting expressions depend on the lengths of paths, measured in the same light-cone coordinate. Each path is associated with a denominator equal to a "light-cone deficit," analogous to the "energy deficits" of momentum-space time- or light-cone-ordered perturbation theory. In effect, the role played by intermediate states in momentum space is played by paths between external fields in coordinate space. We derive a class of identities satisfied by coordinate diagrams, from which their imaginary parts can be derived. Using scalar QED as an example, we show how the eikonal approximation arises naturally when the external points in a Green function approach the light cone, and we give applications to products of Wilson lines. Although much of our discussion is directed at massless fields in four dimensions, we extend the formalism to massive fields and dimensional regularization.
Path Models of Vocal Emotion Communication.
Tanja Bänziger
Full Text Available We propose to use a comprehensive path model of vocal emotion communication, encompassing encoding, transmission, and decoding processes, to empirically model data sets on emotion expression and recognition. The utility of the approach is demonstrated for two data sets from two different cultures and languages, based on corpora of vocal emotion enactment by professional actors and emotion inference by naïve listeners. Lens model equations, hierarchical regression, and multivariate path analysis are used to compare the relative contributions of objectively measured acoustic cues in the enacted expressions and subjective voice cues as perceived by listeners to the variance in emotion inference from vocal expressions for four emotion families (fear, anger, happiness, and sadness. While the results confirm the central role of arousal in vocal emotion communication, the utility of applying an extended path modeling framework is demonstrated by the identification of unique combinations of distal cues and proximal percepts carrying information about specific emotion families, independent of arousal. The statistical models generated show that more sophisticated acoustic parameters need to be developed to explain the distal underpinnings of subjective voice quality percepts that account for much of the variance in emotion inference, in particular voice instability and roughness. The general approach advocated here, as well as the specific results, open up new research strategies for work in psychology (specifically emotion and social perception research and engineering and computer science (specifically research and development in the domain of affective computing, particularly on automatic emotion detection and synthetic emotion expression in avatars.
Isosynchronous paths on a rotating surface
Ashby, Neil
2014-01-01
In special relativity, clock networks may be self-consistently synchronized in an inertial frame by slowly transporting clocks, or by exchanging electromagnetic signals between network nodes. However, clocks at rest in a rotating coordinate system--such as on the surface of the rotating earth--cannot be self-consistently synchronized by such processes, due to the Sagnac effect. Discrepancies that arise are proportional to the area swept out by a vector from the rotation axis to the portable clock or electromagnetic pulse, projected onto a plane normal to the rotation axis. This raises the question whether paths of minimal or extremal length can be found, for which the Sagnac discrepancies are zero. This paper discusses the variational problem of finding such "isosynchronous" paths on rotating discs and rotating spheres. On a disc, the problem resembles the classical isoperimetric problem and the paths turn out to be circular arcs. On a rotating sphere, however, between any two endpoints there are an infinite ...
Purely geometric path integral for spin foams
Shirazi, Atousa Chaharsough
2013-01-01
Spin-foams are a proposal for defining the dynamics of loop quantum gravity via path integral. In order for a path integral to be at least formally equivalent to the corresponding canonical quantization, at each point in the space of histories it is important that the integrand have not only the correct phase -- a topic of recent focus in spin-foams -- but also the correct modulus, usually referred to as the measure factor. The correct measure factor descends from the Liouville measure on the reduced phase space, and its calculation is a task of canonical analysis. The covariant formulation of gravity from which spin-foams are derived is the Plebanski-Holst formulation, in which the basic variables are a Lorentz connection and a Lorentz-algebra valued two-form, called the Plebanski two-form. However, in the final spin-foam sum, one sums over only spins and intertwiners, which label eigenstates of the Plebanski two-form alone. The spin-foam sum is therefore a discretized version of a Plebanski-Holst path integ...
Path integrals for dimerized quantum spin systems
Foussats, Adriana, E-mail: afoussats@gmail.co [Facultad de Ciencias Exactas, Ingenieria y Agrimensura and Instituto de Fisica Rosario (UNR-CONICET), Av. Pellegrini 250, 2000 Rosario (Argentina); Greco, Andres [Facultad de Ciencias Exactas, Ingenieria y Agrimensura and Instituto de Fisica Rosario (UNR-CONICET), Av. Pellegrini 250, 2000 Rosario (Argentina); Muramatsu, Alejandro [Institut fuer Theoretische Physik III, Universitaet Stuttgart, Pfaffenwaldring 57, D-70550 Stuttgart (Germany)
2011-01-11
Dimerized quantum spin systems may appear under several circumstances, e.g. by a modulation of the antiferromagnetic exchange coupling in space, or in frustrated quantum antiferromagnets. In general, such systems display a quantum phase transition to a Neel state as a function of a suitable coupling constant. We present here two path-integral formulations appropriate for spin S=1/2 dimerized systems. The first one deals with a description of the dimers degrees of freedom in an SO(4) manifold, while the second one provides a path-integral for the bond-operators introduced by Sachdev and Bhatt. The path-integral quantization is performed using the Faddeev-Jackiw symplectic formalism for constrained systems, such that the measures and constraints that result from the algebra of the operators is provided in both cases. As an example we consider a spin-Peierls chain, and show how to arrive at the corresponding field-theory, starting with both an SO(4) formulation and bond-operators.
Free path lengths in quasi crystals
Wennberg, Bernt
2012-01-01
The Lorentz gas is a model for a cloud of point particles (electrons) in a distribution of scatterers in space. The scatterers are often assumed to be spherical with a fixed diameter $d$, and the point particles move with constant velocity between the scatterers, and are specularly reflected when hitting a scatterer. There is no interaction between point particles. An interesting question concerns the distribution of free path lengths, i.e. the distance a point particle moves between the scattering events, and how this distribution scales with scatterer diameter, scatterer density and the distribution of the scatterers. It is by now well known that in the so-called Boltzmann-Grad limit, a Poisson distribution of scatters leads to an exponential distribution of free path lengths, whereas if the scatterer distribution is periodic, the distribution of free path behaves asymptotically like a Cauchy distribution. This paper considers the case when the scatters are distributed on a quasi crystal, i.e. non periodica...
Analyzing Complex Reaction Mechanisms Using Path Sampling.
van Erp, Titus S; Moqadam, Mahmoud; Riccardi, Enrico; Lervik, Anders
2016-11-08
We introduce an approach to analyze collective variables (CVs) regarding their predictive power for a reaction. The method is based on already available path sampling data produced by, for instance, transition interface sampling or forward flux sampling, which are path sampling methods used for efficient computation of reaction rates. By a search in CV space, a measure of predictiveness can be optimized and, in addition, the number of CVs can be reduced using projection operations which keep this measure invariant. The approach allows testing hypotheses on the reaction mechanism but could, in principle, also be used to construct the phase-space committor surfaces without the need of additional trajectory sampling. The procedure is illustrated for a one-dimensional double-well potential, a theoretical model for an ion-transfer reaction in which the solvent structure can lower the barrier, and an ab initio molecular dynamics study of water auto-ionization. The analysis technique enhances the quantitative interpretation of path sampling data which can provide clues on how chemical reactions can be steered in desired directions.
Path integral quantization of parametrised field theory
Varadarajan, M
2004-01-01
Free scalar field theory on a flat spacetime can be cast into a generally covariant form known as parametrised field theory in which the action is a functional of the scalar field as well as the embedding variables which describe arbitrary, in general curved, foliations of the flat spacetime. We construct the path integral quantization of parametrised field theory in order to analyse issues at the interface of quantum field theory and general covariance in a path integral context. We show that the measure in the Lorentzian path integral is non-trivial and is the analog of the Fradkin- Vilkovisky measure for quantum gravity. We construct Euclidean functional integrals in the generally covariant setting of parametrised field theory using key ideas of Schleich and show that our constructions imply the existence of non-standard `Wick rotations' of the standard free scalar field 2 point function. We develop a framework to study the problem of time through computations of scalar field 2 point functions. We illustra...
All new custom path photo book creation
Wang, Wiley; Muzzolini, Russ
2012-03-01
In this paper, we present an all new custom path to allow consumers to have full control to their photos and the format of their books, while providing them with guidance to make their creation fast and easy. The users can choose to fully automate the initial creation, and then customize every page. The system manage many design themes along with numerous design elements, such as layouts, backgrounds, embellishments and pattern bands. The users can also utilize photos from multiple sources including their computers, Shutterfly accounts, Shutterfly Share sites and Facebook. The users can also use a photo as background, add, move and resize photos and text - putting what they want where they want instead of being confined to templates. The new path allows users to add embellishments anywhere in the book, and the high-performance platform can support up to 1,000 photos per book and up to 25 pictures per page. The path offers either Smart Autofill or Storyboard features allowing customers to populate their books with photos so they can add captions and customize the pages.
Discovering Attack Path Oriented-IP Traceback
Fu Jianming(傅建明); Zhu Fuxi; Peng Guojun
2003-01-01
The technique of IP traceback may effectively block DOS (Denial Of Service) and meet the requirement of the computer forensic, but its accuracy depends upon that condition that each node in the Internet must support IP packet marking or detected agents. So far, this requirement is not satisfied. On the basis of traditional traceroute,this paper investigates the efficiency of discovering path methods from aspects of the size and order of detecting packets, and the length of paths.It points out that the size of padding in probed packets has a slight effect on discovering latency, and the latency with the method of bulk sending-receiving is much smaller than one with the traditional traceroute. Moreover, the loss rate of packets with the technique of TTL (Time To Live) which increases monotonously is less than that with the technique of TTL which decreases monotonously. Lastly,OS (Operating System) passive fingerprint is used as heuristic to predict the length of the discovered path so as to reduce disturbance in network traffic.
Auditory perception of motor vehicle travel paths.
Ashmead, Daniel H; Grantham, D Wesley; Maloff, Erin S; Hornsby, Benjamin; Nakamura, Takabun; Davis, Timothy J; Pampel, Faith; Rushing, Erin G
2012-06-01
These experiments address concerns that motor vehicles in electric engine mode are so quiet that they pose a risk to pedestrians, especially those with visual impairments. The "quiet car" issue has focused on hybrid and electric vehicles, although it also applies to internal combustion engine vehicles. Previous research has focused on detectability of vehicles, mostly in quiet settings. Instead, we focused on the functional ability to perceive vehicle motion paths. Participants judged whether simulated vehicles were traveling straight or turning, with emphasis on the impact of background traffic sound. In quiet, listeners made the straight-or-turn judgment soon enough in the vehicle's path to be useful for deciding whether to start crossing the street. This judgment is based largely on sound level cues rather than the spatial direction of the vehicle. With even moderate background traffic sound, the ability to tell straight from turn paths is severely compromised. The signal-to-noise ratio needed for the straight-or-turn judgment is much higher than that needed to detect a vehicle. Although a requirement for a minimum vehicle sound level might enhance detection of vehicles in quiet settings, it is unlikely that this requirement would contribute to pedestrian awareness of vehicle movements in typical traffic settings with many vehicles present. The findings are relevant to deliberations by government agencies and automobile manufacturers about standards for minimum automobile sounds and, more generally, for solutions to pedestrians' needs for information about traffic, especially for pedestrians with sensory impairments.
Path Models of Vocal Emotion Communication.
Bänziger, Tanja; Hosoya, Georg; Scherer, Klaus R
2015-01-01
We propose to use a comprehensive path model of vocal emotion communication, encompassing encoding, transmission, and decoding processes, to empirically model data sets on emotion expression and recognition. The utility of the approach is demonstrated for two data sets from two different cultures and languages, based on corpora of vocal emotion enactment by professional actors and emotion inference by naïve listeners. Lens model equations, hierarchical regression, and multivariate path analysis are used to compare the relative contributions of objectively measured acoustic cues in the enacted expressions and subjective voice cues as perceived by listeners to the variance in emotion inference from vocal expressions for four emotion families (fear, anger, happiness, and sadness). While the results confirm the central role of arousal in vocal emotion communication, the utility of applying an extended path modeling framework is demonstrated by the identification of unique combinations of distal cues and proximal percepts carrying information about specific emotion families, independent of arousal. The statistical models generated show that more sophisticated acoustic parameters need to be developed to explain the distal underpinnings of subjective voice quality percepts that account for much of the variance in emotion inference, in particular voice instability and roughness. The general approach advocated here, as well as the specific results, open up new research strategies for work in psychology (specifically emotion and social perception research) and engineering and computer science (specifically research and development in the domain of affective computing, particularly on automatic emotion detection and synthetic emotion expression in avatars).
Adaptive path planning: Algorithm and analysis
Chen, Pang C.
1995-03-01
To address the need for a fast path planner, we present a learning algorithm that improves path planning by using past experience to enhance future performance. The algorithm relies on an existing path planner to provide solutions difficult tasks. From these solutions, an evolving sparse work of useful robot configurations is learned to support faster planning. More generally, the algorithm provides a framework in which a slow but effective planner may be improved both cost-wise and capability-wise by a faster but less effective planner coupled with experience. We analyze algorithm by formalizing the concept of improvability and deriving conditions under which a planner can be improved within the framework. The analysis is based on two stochastic models, one pessimistic (on task complexity), the other randomized (on experience utility). Using these models, we derive quantitative bounds to predict the learning behavior. We use these estimation tools to characterize the situations in which the algorithm is useful and to provide bounds on the training time. In particular, we show how to predict the maximum achievable speedup. Additionally, our analysis techniques are elementary and should be useful for studying other types of probabilistic learning as well.
Handbook for nuclear non-proliferation
Lee, Byung Wook; Oh, Keun Bae; Lee, Kwang Seok; Lee, Dong Jin; Ko, Han Seok
1997-05-01
This book analyzed international non-proliferation regime preventing from spread of nuclear weapon. This book took review from the historical background of non-proliferation regime to the recent changes and status. The regime, here, is divided into multilateral and bilateral regime. First of all, this book reports four multilateral treaties concluded for non-proliferation such as NPT, NWFZ, CTBT and others. Secondly, international organization and regimes concerned with non-proliferation are analyzed with emphasis of UN, IAEA, ZC and NSG, Regional Safeguards System and international conference. Finally, this book report the current circumstances of nuclear cooperation agreement related with Korea which is an important means for bilateral regime. (author). 13 tabs., 2 figs.
A Note on the Stochastic Nature of Feynman Quantum Paths
L. Botelho, Luiz C.
2016-06-01
We propose a Fresnel stochastic white noise framework to analyze the stochastic nature of the Feynman paths entering on the Feynman Path Integral expression for the Feynman Propagator of a particle quantum mechanically moving under a time-independent potential.
A Note on the Stochastic Nature of Feynman Quantum Paths
Botelho, Luiz C. L.
2016-11-01
We propose a Fresnel stochastic white noise framework to analyze the stochastic nature of the Feynman paths entering on the Feynman Path Integral expression for the Feynman Propagator of a particle quantum mechanically moving under a time-independent potential.
Technology Paths in Energy-Efficient and Sustainable Construction
2015-01-01
Various tehcnology paths and regimes, Building codes and standards in energy, eco and sustainable housing......Various tehcnology paths and regimes, Building codes and standards in energy, eco and sustainable housing...
Eosinophils induce airway smooth muscle cell proliferation.
Halwani, Rabih; Vazquez-Tello, Alejandro; Sumi, Yuki; Pureza, Mary Angeline; Bahammam, Ahmed; Al-Jahdali, Hamdan; Soussi-Gounni, Abdelillah; Mahboub, Bassam; Al-Muhsen, Saleh; Hamid, Qutayba
2013-04-01
Asthma is characterized by eosinophilic airway inflammation and remodeling of the airway wall. Features of airway remodeling include increased airway smooth muscle (ASM) mass. However, little is known about the interaction between inflammatory eosinophils and ASM cells. In this study, we investigated the effect of eosinophils on ASM cell proliferation. Eosinophils were isolated from peripheral blood of mild asthmatics and non-asthmatic subjects and co-cultured with human primary ASM cells. ASM proliferation was estimated using Ki-67 expression assay. The expression of extracellular matrix (ECM) mRNA in ASM cells was measured using quantitative real-time PCR. The role of eosinophil derived Cysteinyl Leukotrienes (CysLTs) in enhancing ASM proliferation was estimated by measuring the release of leukotrienes from eosinophils upon their direct contact with ASM cells using ELISA. This role was confirmed either by blocking eosinophil-ASM contact or co-culturing them in the presence of leukotrienes antagonist. ASM cells co-cultured with eosinophils, isolated from asthmatics, but not non-asthmatics, had a significantly higher rate of proliferation compared to controls. This increase in ASM proliferation was independent of their release of ECM proteins but dependent upon eosinophils release of CysLTs. Eosinophil-ASM cell to cell contact was required for CysLTs release. Preventing eosinophil contact with ASM cells using anti-adhesion molecules antibodies, or blocking the activity of eosinophil derived CysLTs using montelukast inhibited ASM proliferation. Our results indicated that eosinophils contribute to airway remodeling during asthma by enhancing ASM cell proliferation and hence increasing ASM mass. Direct contact of eosinophils with ASM cells triggers their release of CysLTs which enhance ASM proliferation. Eosinophils, and their binding to ASM cells, constitute a potential therapeutic target to interfere with the series of biological events leading to airway remodeling
Airway Epithelium Stimulates Smooth Muscle Proliferation
Malavia, Nikita K.; Raub, Christopher B.; Mahon, Sari B.; Brenner, Matthew; Reynold A Panettieri; George, Steven C.
2009-01-01
Communication between the airway epithelium and stroma is evident during embryogenesis, and both epithelial shedding and increased smooth muscle proliferation are features of airway remodeling. Hence, we hypothesized that after injury the airway epithelium could modulate airway smooth muscle proliferation. Fully differentiated primary normal human bronchial epithelial (NHBE) cells at an air–liquid interface were co-cultured with serum-deprived normal primary human airway smooth muscle cells (...
Effect of Loading Paths on HydroformingTubular Square Components
无
2001-01-01
The influence of loading path on tube hydroforming process is discussed in this paper with finiteelement simulation. Four different loading paths are utilized in simulating the forming process of square tubular component with hydroforming and the result of different loading path is presented. Among the result, the thickness distribution of bilinear loading path is the most uniform one. It shows that the increase of punch displacement in the stage of high pressure is beneficial to the forming of component for optimized stress condition.
Inversion of signature for paths of bounded variation
Lyons, Terry
2011-01-01
We develop two methods to reconstruct a path of bounded variation from its signature. The first method gives a simple and explicit expression of any axis path in terms of its signature, but it does not apply directlty to more general ones. The second method, based on an approximation scheme, recovers any tree-reduced path from its signature as the limit of a uniformly convergent sequence of lattice paths.
A Tool Path Generation Strategy for Sculptured Surfaces Machining
Chen Tao; Zhong Yifang; Zhou Ji
2001-01-01
This paper presents a strategy to generate interference-free tool paths for machiningsculptured surfaces. The strategy proposed here is first to determine the tool path topology. Thevalues of the step length and the path interval are then calculated based on the machining tolerancerequirements. After detecting and eliminating the tool interference, the interference-free tool path isgenerated. The effectiveness of the developed algorithm is demonstrated through simulation andactual cutting tests.
Managing Proliferation Issues with Iran
Nelson, C. Richard; Saltiel, David H.
2002-02-15
. Russian policy, in particular, will continue to play a vital role in determining the extent to which Iran is able to pursue WMD options. Without a fundamental change in the regional security environment, however, there is little reason to expect changes in Iranian WMD and missile policies, and the United States, acting alone and short of war, cannot prevent Iran from ultimately developing WMD and delivery systems. Furthermore, U.S. policies that take a tougher line with Russia, China and North Korea are not likely to lead to more restraint among these potential sources of WMD and missile technology. In the absence of engagement with Iran, unilateral U.S. economic sanctions will remain the principal, if flawed, U.S. policy tool for seeking to prevent Iran from acquiring WMD. The rationale is that by discouraging trade and investment, particularly in Iran's energy sector, the government of Iran will have less revenue to pursue proliferation. Without broad international support for economic isolation, however, such an effort may hinder Iran's WMD programs, though it cannot block them. Finally, options are needed to deal with major failures in nonproliferation efforts. These options include measures to deter Iranian use of WMD, to defend against their use if deterrence fails, and to destroy Iranian WMD capabilities should the need arise.
Erenel, Fahri
2015-01-01
Individuals who embraces one of the leadership styles of Path-Goal Leadership Theory which is one of the leadership theories, can be succesful at making the work group effective, for these leadership styles enables leaders to assess needs and clarify goals.Looking at studies in Turkish literature, it is noticed that leadership behaviours were examined in the terms of Path-Goal Leadership Theory however the relationship between leadership styles in this theory and work performance were not exa...
ERENEL, Fahri
2016-01-01
Individuals who embraces one of the leadership styles of Path-Goal Leadership Theory which is one of the leadership theories, can be succesful at making the work group effective, for these leadership styles enables leaders to assess needs and clarify goals.Looking at studies in Turkish literature, it is noticed that leadership behaviours were examined in the terms of Path-Goal Leadership Theory however the relationship between leadership styles in this theory and work performance were not exa...
Guo, Haipeng; Zhang, Xin [Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250012 (China); Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012 (China); Cui, Yuqian [Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012 (China); Deng, Wei [Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060 (China); Xu, Dachun [Department of Cardiology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai 200072 (China); Han, Hui; Wang, Hao [Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250012 (China); Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012 (China); Chen, Yuguo [Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012 (China); Li, Yu, E-mail: qlliyu@126.com [Department of Respiratory, Qilu Hospital of Shandong University, Jinan 250012 (China); Wu, Dawei, E-mail: wdwu55@163.com [Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250012 (China); Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan 250012 (China)
2014-07-18
Highlights: • We focus on PASMCs proliferation in the pathogenesis of PAH. • Isorhynchophylline inhibited PASMCs proliferation and alleviated PAH. • IRN blocked PDGF-Rβ phosphorylation and its downstream signal transduction. • IRN regulated cyclins and CDKs to arrest cell cycle in the G0/G1 phase. • We reported IRN has the potential to be a candidate for PAH treatment. - Abstract: Increased pulmonary arterial smooth muscle cells (PASMCs) proliferation is a key pathophysiological component of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH). Isorhynchophylline (IRN) is a tetracyclic oxindole alkaloid isolated from the Chinese herbal medicine Uncaria rhynchophylla. It has long been used clinically for treatment of cardiovascular and cerebrovascular diseases. However, very little is known about whether IRN can influence the development of PAH. Here we examined the effect of IRN on monocrotaline (MCT) induced PAH in rats. Our data demonstrated that IRN prevented MCT induced PAH in rats, as assessed by right ventricular (RV) pressure, the weight ratio of RV to (left ventricular + septum) and RV hypertrophy. IRN significantly attenuated the percentage of fully muscularized small arterioles, the medial wall thickness, and the expression of smooth muscle α-actin (α-SMA) and proliferating cell nuclear antigen (PCNA). In vitro studies, IRN concentration-dependently inhibited the platelet-derived growth factor (PDGF)-BB-induced proliferation of PASMCs. Fluorescence-activated cell-sorting analysis showed that IRN caused G0/G1 phase cell cycle arrest. IRN-induced growth inhibition was associated with downregulation of Cyclin D1 and CDK6 as well as an increase in p27Kip1 levels in PDGF-BB-stimulated PASMCs. Moreover, IRN negatively modulated PDGF-BB-induced phosphorylation of PDGF-Rβ, ERK1/2, Akt/GSK3β, and signal transducers and activators of transcription 3 (STAT3). These results demonstrate that IRN could inhibit PASMCs proliferation and
K shortest paths in stochastic time-dependent networks
Nielsen, Lars Relund; Pretolani, Daniele; Andersen, Kim Allan
2004-01-01
, finding the a priori shortest path is NP-hard, while the best time-adaptive strategy can be found in polynomial time. In this paper, we propose a solution method for the a priori shortest path problem, and we show that it can be easily adapted to the ranking of the first K shortest paths. Moreover, we...
14 CFR 25.115 - Takeoff flight path.
2010-01-01
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Takeoff flight path. 25.115 Section 25.115... STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight Performance § 25.115 Takeoff flight path. (a) The takeoff flight path shall be considered to begin 35 feet above the takeoff surface at the end of the...
Sub-optimality analysis of mobile robot rolling path planning
张纯刚; 席裕庚
2003-01-01
Rolling planning is an efficient method for path planning in uncertain environment. In this paper, the general principle and algorithm of mobile robot path planning based on rolling windows are studied. The sub-optimality of rolling path planning is analyzed in details and explained with a concrete example.
Generating Approximative Minimum Length Paths in 3D for UAVs
Schøler, Flemming; la Cour-Harbo, Anders; Bisgaard, Morten
2012-01-01
We consider the challenge of planning a minimum length path from an initial position to a desired position for a rotorcraft. The path is found in a 3-dimensional Euclidean space containing a geometric obstacle. We base our approach on visibility graphs which have been used extensively for path pl...