WorldWideScience

Sample records for proliferation path assessment

  1. Laser enrichment: a new path to proliferation

    International Nuclear Information System (INIS)

    Casper, B.M.

    1977-01-01

    The use of lasers to obtain enriched uranium is an easier and cheaper method than methods currently in use. The immediate concern is that it could promote easy access to nuclear weapons by countries that do not presently have them. Mr. Casper feels that the U.S. government is working against itself; while the State Department is seeking to block one path to proliferation, ERDA laboratories are developing new technology that could open another. The proliferation implications have not been factored in a serious way into the decisions to proceed with this research. It is also clear that the United States does not now have a comprehensive policy that deals with all potentially important paths to proliferation, including laser enrichment. Mr. Casper states that there is still time to stop and consider whether laser enrichment should be developed, in light of its broader consequences. But this will not happen if the decisions are left exclusively in the hands of those promoting the technology, the author says. It is just this sort of situation that prompted the creation of several government institutions to provide independent assessments of new technologies. The Office of Technology Assessment, the Nuclear Regulatory Commission, and the Arms Control and Disarmament Agency all have the authority to intervene. Laser enrichment provides a good test of these institutions and of the viability of the concept of technology assessment. The status, benefits and risks, and the policy needed on laser research are discussed

  2. Comparative analysis of proliferation resistance assessment methodologies

    International Nuclear Information System (INIS)

    Takaki, Naoyuki; Kikuchi, Masahiro; Inoue, Naoko; Osabe, Takeshi

    2005-01-01

    Comparative analysis of the methodologies was performed based on the discussions in the international workshop on 'Assessment Methodology of Proliferation Resistance for Future Nuclear Energy Systems' held in Tokyo, on March 2005. Through the workshop and succeeding considerations, it is clarified that the proliferation resistance assessment methodologies are affected by the broader nuclear options being pursued and also by the political situations of the state. Even the definition of proliferation resistance, despite the commonality of fundamental issues, derives from perceived threat and implementation circumstances inherent to the larger programs. Deep recognitions of the 'difference' among communities would help us to make further essential and progressed discussion with harmonization. (author)

  3. Energy efficiency and proliferation assessment factors

    International Nuclear Information System (INIS)

    1979-02-01

    The objective of INFCE is to evaluate the nuclear fuel cycles from the point of view of their ability to satisfy the worldwide nuclear energy needs, while minimizing the proliferation risks. Accordingly, the different working groups have to take into consideration as well the energy-efficiency and the proliferation-resistance of these nuclear fuel cycles. The present working paper is aimed at suggesting the main assessment factors which should be taken into consideration

  4. Utility of Social Modeling for Proliferation Assessment - Preliminary Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Coles, Garill A.; Gastelum, Zoe N.; Brothers, Alan J.; Thompson, Sandra E.

    2009-06-01

    This Preliminary Assessment draft report will present the results of a literature search and preliminary assessment of the body of research, analysis methods, models and data deemed to be relevant to the Utility of Social Modeling for Proliferation Assessment research. This report will provide: 1) a description of the problem space and the kinds of information pertinent to the problem space, 2) a discussion of key relevant or representative literature, 3) a discussion of models and modeling approaches judged to be potentially useful to the research, and 4) the next steps of this research that will be pursued based on this preliminary assessment. This draft report represents a technical deliverable for the NA-22 Simulations, Algorithms, and Modeling (SAM) program. Specifically this draft report is the Task 1 deliverable for project PL09-UtilSocial-PD06, Utility of Social Modeling for Proliferation Assessment. This project investigates non-traditional use of social and cultural information to improve nuclear proliferation assessment, including nonproliferation assessment, proliferation resistance assessments, safeguards assessments and other related studies. These assessments often use and create technical information about the State’s posture towards proliferation, the vulnerability of a nuclear energy system to an undesired event, and the effectiveness of safeguards. This project will find and fuse social and technical information by explicitly considering the role of cultural, social and behavioral factors relevant to proliferation. The aim of this research is to describe and demonstrate if and how social science modeling has utility in proliferation assessment.

  5. Proliferation resistance assessment of thermal recycle systems

    International Nuclear Information System (INIS)

    1979-02-01

    This paper examines the major proliferation aspects of thermal recycle systems and the extent to which technical or institutional measures could increase the difficulty or detectability of misuse of the system by would-be proliferators. It does this by examining the various activities necessary to acquire weapons-usable material using a series of assessment factors; resources required, time required, detectability. It is concluded that resistance to proliferation could be improved substantially by collecting reprocessing, conversion and fuel fabrication plants under multi national control and instituting new measures to protect fresh MOX fuel. Resistance to theft at sub-national level could be improved by co-location of sensitive facilities high levels of physical protection at plants and during transportation and possibly by adding a radiation barrier to MOX prior to shipment

  6. Proliferation resistance assessment of nuclear systems

    International Nuclear Information System (INIS)

    1978-09-01

    The paper focuses on examining the degree to which nuclear systems could be used to acquire nuclear weapons material. It establishes a framework for proliferation resistance assessment and illustrates its applicability through an analysis of reference systems for once-through cycles, breeder cycles and thermal recycle. On a more tentative basis, the approach is applied to various alternative technical and institutional measures. This paper was also submitted to Working Groups 5 and 8

  7. Proliferation resistance assessment of pyro processing

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, E. H.; Ko, W. I.; Kim, H. D. [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    In 2002, world experts gathered and defined the term proliferation resistance as 'the characteristic of a nuclear energy system that impedes the diversion or undeclared production of nuclear material, or misuse of technology, by State in order to acquire nuclear weapons or other nuclear explosive devices.' The same report also defines the following terms: Intrinsic barriers (technical features) of proliferation resistance are features that result from the technical design of nuclear energy systems, including those that facilitate the implementation of extrinsic measures. Extrinsic barriers (institutional measures) of proliferation resistance are features that result from the decisions and undertakings of states related to nuclear energy system. Intrinsic barriers are further divided into material barriers.the 'intrinsic, or inherent, qualities of materials that reduce the inherent desirability or attractiveness of the material as an explosive' and technical barriers. The 'intrinsic technical lements of the fuel cycle, its facilities, processes, and equipment that serve to make it difficult to gain access to materials and/or to use or misuse facilities to obtain weapons usable materials.' Material barriers include isotopic, chemical, radiological, mass and bulk, and detectability, whereas technical barriers include facility unattractiveness, accessibility, available fissile mass, detectability of and time required for diversion, and skills, expertise, and knowledge. Assessing the proliferation resistance of pyro processing is meaningful only when compared with other processes. This paper attempts to discuss the features of pyro processing by comparing it with direct disposal and aqueous separation processes from a proliferation resistance viewpoint.

  8. Proliferation resistance assessment of nuclear systems

    International Nuclear Information System (INIS)

    1978-09-01

    The first part of the present paper describes the basic assessment procedure that is adopted in the analysis of the three generic nuclear systems. Once-through, fast breeder, and thermal recycle systems are then treated in Sections II, III, and IV, respectively. In each of these sections, a reference system is examined, possible technical and institutional improvements are considered, and alternative system types are indicated. Section V then discusses the relative proliferation resistance of the three generic systems. Although this paper emphasizes the analysis and comparison of individual fuel cycle alternatives, Section V indicates briefly how these analyses then have to be considered in a broader context where systems coexist

  9. Utility of Social Modeling for Proliferation Assessment - Preliminary Findings

    International Nuclear Information System (INIS)

    Coles, Garill A.; Gastelum, Zoe N.; Brothers, Alan J.; Thompson, Sandra E.

    2009-01-01

    Often the methodologies for assessing proliferation risk are focused around the inherent vulnerability of nuclear energy systems and associated safeguards. For example an accepted approach involves ways to measure the intrinsic and extrinsic barriers to potential proliferation. This paper describes preliminary investigation into non-traditional use of social and cultural information to improve proliferation assessment and advance the approach to assessing nuclear material diversion. Proliferation resistance assessment, safeguard assessments and related studies typically create technical information about the vulnerability of a nuclear energy system to diversion of nuclear material. The purpose of this research project is to find ways to integrate social information with technical information by explicitly considering the role of culture, groups and/or individuals to factors that impact the possibility of proliferation. When final, this work is expected to describe and demonstrate the utility of social science modeling in proliferation and proliferation risk assessments.

  10. Critical crack path assessments in failure investigations

    Directory of Open Access Journals (Sweden)

    Robert D. Caligiuri

    2015-10-01

    Full Text Available This paper presents a case study in which identification of the controlling crack path was critical to identifying the root cause of the failure. The case involves the rupture of a 30-inch (0.76 m natural gas pipeline in 2010 that tragically led to the destruction of a number of homes and the loss of life. The segment of the pipeline that ruptured was installed in 1956. The longitudinal seam of the segment that ruptured was supposed to have been fabricated by double submerged arc welding. Unfortunately, portions of the segment only received a single submerged arc weld on the outside, leaving unwelded areas on the inside diameter. Post-failure examination of the segment revealed that the rupture originated at one of these unwelded areas. Examination also revealed three additional crack paths or zones emanating from the unwelded area: a zone of ductile tearing, a zone of fatigue, and a zone of cleavage fracture, in that sequence. Initial investigators ignored the ductile tear, assumed the critical crack path was the fatigue component, and (incorrectly concluded that the root cause of the incident was the failure of the operator to hydrotest the segment after it was installed in 1956. However, as discussed in this paper, the critical path or mechanism was the ductile tear. Furthermore, it was determined that the ductile tear was created during the hydrotest at installation by a mechanism known as pressure reversal. Thus the correct root cause of the rupture was the hydrotest the operator subjected the segment to at installation, helping to increase the awareness of operators and regulators about the potential problems associated with hydrotesting.

  11. Risk assessment of alternative proliferation routes

    International Nuclear Information System (INIS)

    Ahmed, S.; Husseiny, A.A.

    1982-01-01

    Multi-Attribute Decision Theory is applied to rank II alternative routes to nuclear proliferation in order of difficulty in acquiring nuclear weapons by nonnuclear countries. The method is based on reducing the various variables affecting the decision to a single function providing a measure for the proliferation route. The results indicate that the most difficult route to obtain atomic weapons is through nuclear power reactors, specifically the liquid-metal fast breeder reactor, heavy water Canada deuterium uranium reactor, and light water reactors such as boiling water and pressurized water reactors. The easiest routes are supercritical centrifuge isotope separation, laser isotope separation, and research reactor. However, nonnuclear routes available that result in substantial damage to life and property are easier than any nuclear route

  12. ASSESSING THE PROLIFERATION RESISTANCE OF INNOVATIVE NUCLEAR FUEL CYCLES

    International Nuclear Information System (INIS)

    BARI, R.; ROGLANS, J.; DENNING, R.; MLADINEO, S.

    2003-01-01

    The National Nuclear Security Administration is developing methods for nonproliferation assessments to support the development and implementation of U.S. nonproliferation policy. This paper summarizes the key results of that effort. Proliferation resistance is the degree of difficulty that a nuclear material, facility, process, or activity poses to the acquisition of one or more nuclear weapons. A top-level measure of proliferation resistance for a fuel cycle system is developed here from a hierarchy of metrics. At the lowest level, intrinsic and extrinsic barriers to proliferation are defined. These barriers are recommended as a means to characterize the proliferation characteristics of a fuel cycle. Because of the complexity of nonproliferation assessments, the problem is decomposed into: metrics to be computed, barriers to proliferation, and a finite set of threats. The spectrum of potential threats of nuclear proliferation is complex and ranges from small terrorist cells to industrialized countries with advanced nuclear fuel cycles. Two general categories of methods have historically been used for nonproliferation assessments: attribute analysis and scenario analysis. In the former, attributes of the systems being evaluated (often fuel cycle systems) are identified that affect their proliferation potential. For a particular system under consideration, the attributes are weighted subjectively. In scenario analysis, hypothesized scenarios of pathways to proliferation are examined. The analyst models the process undertaken by the proliferant to overcome barriers to proliferation and estimates the likelihood of success in achieving a proliferation objective. An attribute analysis approach should be used at the conceptual design level in the selection of fuel cycles that will receive significant investment for development. In the development of a detailed facility design, a scenario approach should be undertaken to reduce the potential for design vulnerabilities

  13. Assessing the Learning Path Specification: a Pragmatic Quality Approach

    NARCIS (Netherlands)

    Janssen, José; Berlanga, Adriana; Heyenrath, Stef; Martens, Harrie; Vogten, Hubert; Finders, Anton; Herder, Eelco; Hermans, Henry; Melero, Javier; Schaeps, Leon; Koper, Rob

    2010-01-01

    Janssen, J., Berlanga, A. J., Heyenrath, S., Martens, H., Vogten, H., Finders, A., Herder, E., Hermans, H., Melero Gallardo, J., Schaeps, L., & Koper, R. (2010). Assessing the Learning Path Specification: a Pragmatic Quality Approach. Journal of Universal Computer Science, 16(21), 3191-3209.

  14. Using proliferation assessment methodologies for Safeguards-by-Design

    International Nuclear Information System (INIS)

    Van der Meer, K.; Rossa, R.; Turcanu, C.; Borella, A.

    2013-01-01

    MYRRHA, an accelerator driven system (ADS) is designed as a proton accelerator coupled to a liquid Pb-Bi spallation target, surrounded by a Pb-Bi cooled sub-critical neutron multiplying medium in a pool type configuration. An assessment based on three methodologies was made of the proliferation risks of the MYRRHA ADS in comparison with the BR2 MTR, an existing research reactor at the Belgian Nuclear Research Centre SCK-CEN. The used methodologies were the TOPS (Technical Opportunities to Increase the Proliferation Resistance of Nuclear Power Systems), the PR-PP and the INPRO methodologies. The various features of the methodologies are described and the results of the assessments are given and discussed. It is concluded that it would be useful to define one single methodology with two options to perform a quick and a more detailed assessment. The paper is followed by the slides of the presentation

  15. Energy-efficiency and proliferation-resistance assessment factors

    International Nuclear Information System (INIS)

    1979-02-01

    Assessment factors suggested with regard to energy efficiency are: preservation of natural non-renewable resources: the degree of security of supply which can be achieved; the availability of necessary raw materials and technology; economic feasibility; and acceptability of a fuel cycle from environmental and safety views. In the area of proliferation resistance, it is suggested that the basic element is the political commitment by a Government not to use imported nuclear materials and equipment to manufacture nuclear explosives. 100% proliferation resistance is considered unattainable in practice. The role of international safeguards in detering possible diversion through the risk of early detection is described, and it is argued that efficient safeguards will force a Government willing to go nuclear to withdraw from its safeguards agreements. The second assessment factor, accordingly, is to consider different fuel cycles with regard to the efficient and rapid building up of a nuclear weapons capacity once the country has withdrawn from its safeguards commitments

  16. Assessment of proliferation resistance of thermal recycle systems

    International Nuclear Information System (INIS)

    1979-02-01

    An assessment is made of the proliferation resistance of thermal recycle systems. The safeguards aspects are not addressed. Three routes to the acquisition of materials for nuclear weapons are addressed namely; a deliberate political decision by a government involving the use of dedicated facilities, a deliberate political decision by government involving abuse of nuclear fuel cycle facilities and theft by a subnational group. The most sensitive parts of the reference fuel cycle and the alternative technical measures are examined to judge their relative sensitivity. This is done by examining the difference forms in which plutonium can exist in the fuel cycle. The role which different institutional arrangements can play is also evaluated. From this comparative assessment it is concluded that, taking into account the qualitative nature of the assessment, the different stages of development of the various fuel cycles, the various realizations possible in respect of the deployment of facilities within individual countries and the evolutionary nature of the technical and institutional improvements foreseeable no fuel cycle can be made completely free from abuse. Furthermore it appears that following progressive introduction of features that will improve proliferation resistance there will not be significant differences between the various fuel cycles when compared at the point in time when they are introduced into widespread use. Provided such features are developed and implemented there is no reason on proliferation grounds to prefer one cycle to another

  17. Proliferation Resistance and Safeguards by Design: The Safeguardability Assessment Tool Provided by the INPRO Collaborative Project ''INPRO'' (Proliferation Resistance and Safeguardability Assessment)

    International Nuclear Information System (INIS)

    Haas, E.; Chang, H.-L.; Phillips, J.R.; Listner, C.

    2015-01-01

    Since the INPRO Collaborative Project on Proliferation Resistance and Safeguardability Assessment Tools (PROSA) was launched in 2011, Member State experts have worked with the INPRO Section and the IAEA Department of Safeguards to develop a revised methodology for self-assessment of sustainability in the area of proliferation resistance of a nuclear energy system (NES). With the common understanding that there is ''no proliferation resistance without safeguards'' the revised approach emphasizes the evaluation of a new 'User Requirement' for ''safeguardability'', that combines metrics of effective and efficient implementation of IAEA Safeguards including ''Safeguards-by-Design'' principles. The assessment with safeguardability as the key issue has been devised as a linear process evaluating the NES against a ''Basic Principle'' in the area of proliferation resistance, answering fundamental questions related to safeguards: 1) Do a State's legal commitments, policies and practices provide credible assurance of the exclusively peaceful use of the NES, including a legal basis for verification activities by the IAEA? 2) Does design and operation of the NES facilitate the effective and efficient implementation of IAEA safeguards? To answer those questions, a questionnaire approach has been developed that clearly identifies gaps and weaknesses. Gaps include prospects for improvements and needs for research and development. In this context, the PROSA approach assesses the safeguardability of a NES using a layered ''Evaluation Questionnaire'' that defines Evaluation Parameters (EP), EP-related questions, Illustrative Tests and Screening Questions to present and structure the evidence of findings. An integral part of the assessment process is Safeguards-by-Design, the identification of potential diversion, misuse and concealment strategies (coarse diversion path

  18. Embalse refurbishment - aging, safety assessment, and the path forward

    International Nuclear Information System (INIS)

    Sainz, R.; Fornero, D.; Diaz, G.; Gold, R.; Dam, R.; McCrea, L.

    2009-01-01

    The Embalse Nuclear Power Station has been engaged in Pre-refurbishment activities for two years. The primary focus has been on the first phase Pre-Project Condition Assessment Program (PCAP). This phase of the Refurbishment and Life Extension (RLE) project consists of all preparatory activities that are required to define the refurbishment scope and costs, and for input into the utility business case for the RLE project. As part of an overall Plant Life Management (PLiM) program, the following activities have been performed: 1. Systematic and rigorous condition assessments / life assessments (including Health Prognosis and Recommendations); 2. Assessment of design and safety analysis features at Embalse, relative to current technology and licensing practices; 3. Pre-Project activities related to: Retube, Steam Generator replacement, and Digital Control Computer (DCC) replacement. The program has been a joint effort of Embalse NPS-NASA, AECL, ANSALDO and several other support organizations. Details of the planned program were addressed previously in a paper presented at the 28th CNS Conference (2007), entitled 'Embalse Refurbishment - Pre-Project Condition Assessment Phase 1'. Since that time, significant progress has been made towards completing the assessment program and planning for the next steps. This paper presents the progress of Refurbishment and Life Extension (RLE) Program at Embalse Nuclear Power Station with specific emphasis on the PCAP efforts. This includes a discussion of the benefits and lessons learned from RLE project's perspective, and an overview of some key conclusions of the aging assessments. Finally, this paper outlines the path forward. It should be noted that results of assessments presented in this paper are very conservative. This is driven largely by the fact that there are currently uncertainties in equipment condition that can be addressed through the activities recommended as an outcome of these assessments. (author)

  19. Development of proliferation resistance assessment methodology based on international standard

    International Nuclear Information System (INIS)

    Ko, W. I.; Chang, H. L.; Lee, Y. D.; Lee, J. W.; Park, J. H.; Kim, Y. I.; Ryu, J. S.; Ko, H. S.; Lee, K. W.

    2012-04-01

    Nonproliferation is one of the main requirements to be satisfied by the advanced future nuclear energy systems that have been developed in the Generation IV and INPRO studies. The methodologies to evaluate proliferation resistance has been developed since 1980s, however, the systematic evaluation approach has begun from around 2000. Domestically a study to develop national method to evaluate proliferation resistance (PR) of advanced future nuclear energy systems has started in 2007 as one of the long-term nuclear R and D subjects in order to promote export and international credibility and transparency of national nuclear energy systems and nuclear fuel cycle technology development program. In the first phase (2007-2010) development and improvement of intrinsic evaluation parameters for the evaluation of proliferation resistance, quantification of evaluation parameters, development of evaluation models, and development of permissible ranges of evaluation parameters have been carried out. In the second phase (2010-2012) generic principle of to evaluate PR was established, and techincal guidelines, nuclear material diversion pathway analysis method, and a method to integrate evaluation parameters have been developed. which were applied to 5 alternative nuclear fuel cycles to estimate their appicability and objectivity. In addition, measures to enhance PR of advanced future nuclear energy systems and technical guidelines of PR assessment using intrinsic PR evaluation parameters were developed. Lastly, requlatory requirements to secure nonproliferation requirements of nuclear energy systems from the early design stage, operation and to decommissioning which will support the export of newly developed advanced future nuclear energy system

  20. Proliferation resistance assessment of high temperature gas reactors

    Energy Technology Data Exchange (ETDEWEB)

    Chikamatsu N, M. A. [Instituto Tecnologico y de Estudios Superiores de Monterrey, Campus Santa Fe, Av. Carlos Lazo No. 100, Santa Fe, 01389 Mexico D. F. (Mexico); Puente E, F., E-mail: midori.chika@gmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    The Generation IV International Forum has established different objectives for the new generation of reactors to accomplish. These objectives are focused on sustain ability, safety, economics and proliferation resistance. This paper is focused on how the proliferation resistance of the High Temperature Gas Reactors (HTGR) is assessed and the advantages that these reactors present currently. In this paper, the focus will be on explaining why such reactors, HTGR, can achieve the goals established by the GIF and can present a viable option in terms of proliferation resistance, which is an issue of great importance in the field of nuclear energy generation. The reason why the HTGR are being targeted in this writing is that these reactors are versatile, and present different options from modular reactors to reactors with the same size as the ones that are being operated today. Besides their versatility, the HTGR has designed features that might improve on the overall sustain ability of the nuclear reactors. This is because the type of safety features and materials that are used open up options for industrial processes to be carried out; cogeneration for instance. There is a small section that mentions how HTGR s are being developed in the international sector in order to present the current world view in this type of technology and the further developments that are being sought. For the proliferation resistance section, the focus is on both the intrinsic and the extrinsic features of the nuclear systems. The paper presents a comparison between the features of Light Water Reactors (LWR) and the HTGR in order to be able to properly compare the most used technology today and one that is gaining international interest. (Author)

  1. Proliferation resistance assessment of high temperature gas reactors

    International Nuclear Information System (INIS)

    Chikamatsu N, M. A.; Puente E, F.

    2014-10-01

    The Generation IV International Forum has established different objectives for the new generation of reactors to accomplish. These objectives are focused on sustain ability, safety, economics and proliferation resistance. This paper is focused on how the proliferation resistance of the High Temperature Gas Reactors (HTGR) is assessed and the advantages that these reactors present currently. In this paper, the focus will be on explaining why such reactors, HTGR, can achieve the goals established by the GIF and can present a viable option in terms of proliferation resistance, which is an issue of great importance in the field of nuclear energy generation. The reason why the HTGR are being targeted in this writing is that these reactors are versatile, and present different options from modular reactors to reactors with the same size as the ones that are being operated today. Besides their versatility, the HTGR has designed features that might improve on the overall sustain ability of the nuclear reactors. This is because the type of safety features and materials that are used open up options for industrial processes to be carried out; cogeneration for instance. There is a small section that mentions how HTGR s are being developed in the international sector in order to present the current world view in this type of technology and the further developments that are being sought. For the proliferation resistance section, the focus is on both the intrinsic and the extrinsic features of the nuclear systems. The paper presents a comparison between the features of Light Water Reactors (LWR) and the HTGR in order to be able to properly compare the most used technology today and one that is gaining international interest. (Author)

  2. Overview of DOE-NE Proliferation and Terrorism Risk Assessment

    International Nuclear Information System (INIS)

    Sadasivan, Pratap

    2012-01-01

    Research objectives are: (1) Develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of current reactors; (2) Develop improvements in the affordability of new reactors to enable nuclear energy; (3) Develop Sustainable Nuclear Fuel Cycles; and (4) Understand and minimize the risks of nuclear proliferation and terrorism. The goal is to enable the use of risk information to inform NE R and D program planning. The PTRA program supports DOE-NE's goal of using risk information to inform R and D program planning. The FY12 PTRA program is focused on terrorism risk. The program includes a mix of innovative methods that support the general practice of risk assessments, and selected applications.

  3. Establishment of Assessment Methodology Improvement of IAEA INPRO Proliferation Resistance

    International Nuclear Information System (INIS)

    Park, J. H.; Yang, M. S.; Song, K. C.; Ko, W. I.; Kim, H. D.; Kim, Y. I.; Rhee, B. W.; Kim, H. T.

    2008-03-01

    For the development of assessment methodology of acquisition and diversion pathway of nuclear material, the PR assessment methodology which has been developed by GEN-IV PR and PP group was reviewed regarding the acquisition and diversion pathway of nuclear material and we proposed the research areas to develop the model of acquisition and diversion pathway of nuclear material including misuse of fuel cycle facilities and one of the IAEA INPRO CRPs which is aiming to develop its model. From the present study, its preliminary model for acquisition and diversion pathway of nuclear material was obtained. For preliminary evaluation of DUPIC system using methodology of acquisition/diversion pathway of nm and review of pyro-processing system characteristics, the research direction and work procedure was established to develop the assessment methodology of User Requirement 4 of INPRO PR by; 1) selection of the possible pathway to acquire and divert the nuclear material of DUPIC system, 2) the analysis of selected pathway, 3) the development of the assessment methodology of robustness and multiplicity of an INS. And, the PR characteristics and process/material flow analysis of the Pyro-processing system were preliminarily studied. For establishment of R and D direction for an INS and supporting international cooperation research, the collaborative research project titled as 'Acquisition and Diversion pathway analysis of Proliferation Resistance' as one of activities of IAEA INPRO was proposed, since Korean Government decided to actively support the IAEA INPRO. In order to review and clarify the Terms of Reference (TOR) of a Korean Proposed Collaborative Project (ROK1), two INPRO Consultancy Meetings were held. Its results were presented at two INPRO Steering Committees and the finalized TOR of Korean Proposal submit the 12-th INPRO Steering Committee Meeting which was held Dec. 3-5 2007. Four participants including USA, Canada, China and European Community (EC) have decided

  4. Establishment of Assessment Methodology Improvement of IAEA INPRO Proliferation Resistance

    Energy Technology Data Exchange (ETDEWEB)

    Park, J. H.; Yang, M. S.; Song, K. C.; Ko, W. I.; Kim, H. D.; Kim, Y. I.; Rhee, B. W.; Kim, H. T.

    2008-03-15

    For the development of assessment methodology of acquisition and diversion pathway of nuclear material, the PR assessment methodology which has been developed by GEN-IV PR and PP group was reviewed regarding the acquisition and diversion pathway of nuclear material and we proposed the research areas to develop the model of acquisition and diversion pathway of nuclear material including misuse of fuel cycle facilities and one of the IAEA INPRO CRPs which is aiming to develop its model. From the present study, its preliminary model for acquisition and diversion pathway of nuclear material was obtained. For preliminary evaluation of DUPIC system using methodology of acquisition/diversion pathway of nm and review of pyro-processing system characteristics, the research direction and work procedure was established to develop the assessment methodology of User Requirement 4 of INPRO PR by; 1) selection of the possible pathway to acquire and divert the nuclear material of DUPIC system, 2) the analysis of selected pathway, 3) the development of the assessment methodology of robustness and multiplicity of an INS. And, the PR characteristics and process/material flow analysis of the Pyro-processing system were preliminarily studied. For establishment of R and D direction for an INS and supporting international cooperation research, the collaborative research project titled as 'Acquisition and Diversion pathway analysis of Proliferation Resistance' as one of activities of IAEA INPRO was proposed, since Korean Government decided to actively support the IAEA INPRO. In order to review and clarify the Terms of Reference (TOR) of a Korean Proposed Collaborative Project (ROK1), two INPRO Consultancy Meetings were held. Its results were presented at two INPRO Steering Committees and the finalized TOR of Korean Proposal submit the 12-th INPRO Steering Committee Meeting which was held Dec. 3-5 2007. Four participants including USA, Canada, China and European Community (EC

  5. A Study on the Improvement of the INPRO Proliferation Resistance Assessment Methodology

    International Nuclear Information System (INIS)

    Ko, Won Il; Chang, Hong Lae

    2010-07-01

    Within the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO), a methodology for evaluating proliferation resistance (INPRO PR methodology) has been developed. However, User Requirement (UR) 4 regarding multiplicity and robustness of barriers against proliferation ('innovative nuclear energy systems should incorporate multiple proliferation resistance features and measures') remains to be developed. Because the development of a methodology for evaluating User Requirement 4 requires an acquisition/diversion pathway analysis, a systematic approach was developed for the identification and analysis of pathways for the acquisition of weapons-useable nuclear material. This approach was applied to the DUPIC fuel cycle which identified several proliferation target materials and plausible acquisition/diversion pathways. Based on these results, proliferation strategies that a proliferant State could adopt for undeclared removal of nuclear material from the DUPIC fuel cycle have been developed based on the objectives of the proliferation of the State, the quality and quantity of the target material, the time required to acquire the material for the proliferation, and the technical and financial capabilities of the potential proliferant State. The diversion pathway for fresh DUPIC fuel was analyzed using the INPRO User Requirements 1, 2 and 3, and based on these results an assessment procedure and metrics for evaluating the multiplicity and robustness of proliferation barriers has been developed. In conclusion, the multiplicity and robustness of proliferation barriers is not a function of the number of barriers, or of their individual characteristics but is an integrated function of the whole. The robustness of proliferation barriers is measured by determining whether the safeguards goals can be met. The harmonization of INPRO PR methodology with the GIF PR and PP methodology was also considered. It was suggested that, as also confirmed by IAEA

  6. Utility of Social Modeling for Proliferation Assessment - Enhancing a Facility-Level Model for Proliferation Resistance Assessment of a Nuclear Enegry System

    Energy Technology Data Exchange (ETDEWEB)

    Coles, Garill A.; Brothers, Alan J.; Gastelum, Zoe N.; Olson, Jarrod; Thompson, Sandra E.

    2009-10-26

    The Utility of Social Modeling for Proliferation Assessment project (PL09-UtilSocial) investigates the use of social and cultural information to improve nuclear proliferation assessments, including nonproliferation assessments, Proliferation Resistance (PR) assessments, safeguards assessments, and other related studies. These assessments often use and create technical information about a host State and its posture towards proliferation, the vulnerability of a nuclear energy system (NES) to an undesired event, and the effectiveness of safeguards. This objective of this project is to find and integrate social and technical information by explicitly considering the role of cultural, social, and behavioral factors relevant to proliferation; and to describe and demonstrate if and how social science modeling has utility in proliferation assessment. This report describes a modeling approach and how it might be used to support a location-specific assessment of the PR assessment of a particular NES. The report demonstrates the use of social modeling to enhance an existing assessment process that relies on primarily technical factors. This effort builds on a literature review and preliminary assessment performed as the first stage of the project and compiled in PNNL-18438. [ T his report describes an effort to answer questions about whether it is possible to incorporate social modeling into a PR assessment in such a way that we can determine the effects of social factors on a primarily technical assessment. This report provides: 1. background information about relevant social factors literature; 2. background information about a particular PR assessment approach relevant to this particular demonstration; 3. a discussion of social modeling undertaken to find and characterize social factors that are relevant to the PR assessment of a nuclear facility in a specific location; 4. description of an enhancement concept that integrates social factors into an existing, technically

  7. Noninvasive Assessment of Tumor Cell Proliferation in Animal Models

    Directory of Open Access Journals (Sweden)

    Matthias Edinger

    1999-10-01

    Full Text Available Revealing the mechanisms of neoplastic disease and enhancing our ability to intervene in these processes requires an increased understanding of cellular and molecular changes as they occur in intact living animal models. We have begun to address these needs by developing a method of labeling tumor cells through constitutive expression of an optical reporter gene, noninvasively monitoring cellular proliferation in vivo using a sensitive photon detection system. A stable line of HeLa cells that expressed a modified firefly luciferase gene was generated, proliferation of these cells in irradiated severe combined immunodeficiency (SCID mice was monitored. Tumor cells were introduced into animals via subcutaneous, intraperitoneal and intravenous inoculation and whole body images, that revealed tumor location and growth kinetics, were obtained. The number of photons that were emitted from the labeled tumor cells and transmitted through murine tissues was sufficient to detect 1×103 cells in the peritoneal cavity, 1×104 cells at subcutaneous sites and 1×106 circulating cells immediately following injection. The kinetics of cell proliferation, as measured by photon emission, was exponential in the peritoneal cavity and at subcutaneous sites. Intravenous inoculation resulted in detectable colonies of tumor cells in animals receiving more than 1×103 cells. Our demonstrated ability to detect small numbers of tumor cells in living animals noninvasively suggests that therapies designed to treat minimal disease states, as occur early in the disease course and after elimination of the tumor mass, may be monitored using this approach. Moreover, it may be possible to monitor micrometastases and evaluate the molecular steps in the metastatic process. Spatiotemporal analyses of neoplasia will improve the predictability of animal models of human disease as study groups can be followed over time, this method will accelerate development of novel therapeutic

  8. Proliferation Resistance and Safeguardability Assessment of a SFR Metal Fuel Manufacturing Facility (SFMF) using the INPRO Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H. L.; Ko, W. I.; Park, S. H.; Kim, H. D.; Park, G. I. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    To illustrate the proposed Prosta process, to demonstrate its usefulness, and to provide input to a revision of the INPRO manual in the area of proliferation resistance, a case study has been carried out with a conceptually designed sodium cooled fast reactor (SFR) metal fuel manufacturing facility (SFMF), representing novel technology still in the conceptual design phase. A coarse acquisition path analysis has been carried out of the SFMF to demonstrate the assessment process with identified different target materials. The case study demonstrates the usefulness of the proposed PROSA PR assessment process and the interrelationship of the PR assessment with the safeguards-by-design process, identifying potential R and D needs. The PROSA process has been applied to a conceptually designed SFMF, representing novel technology that is still in the conceptual design phase at KAERI. The case study demonstrated that the proposed PROSA process is simpler and easier to perform than the original INPRO methodology and can be applied from the early stage of design showing the relationship of PR assessment to the safeguard-by-design process. New evaluation questionnaire for UR1 is more logical and comprehensive, and provides the legal basis enabling the IAEA to achieve its safeguards objectives including the detection of undeclared nuclear materials and activities. NES information catalogue replacing UR2 was a useful modification and supports safeguardability assessment at the NES and facility level. The proposed PROSA process is also capable to identify strengths and weaknesses of a system in the area of proliferation resistance in a generally understandable form, including R and D gaps that need to be filled in order to meet the criteria for proliferation resistance of a nuclear energy system.

  9. Acquisition/Diversion Pathway Analysis for the Assessment of Proliferation Resistance

    International Nuclear Information System (INIS)

    Chang, Hong Lae; Ko, Won Il

    2009-01-01

    The INPRO methodology in the area of proliferation resistance (PR) has one basic principle and five user requirements with relevant criteria, indicators, evaluation parameters, etc. The two Korean case studies on proliferation resistance of the DUPIC fuel cycle during 2004 and 2005 and various consultancy meetings have contributed to the establishment of the assessment metrics and procedures for three user requirements regarding States' commitment, attractiveness of nuclear material and technology, and difficulty and detectability of diversion. However, the assessment indicators and procedure for user requirement 4 regarding multiplicity and robustness of barriers against proliferation still need to be developed. In this paper, a systematic approach to identify and analyze the acquisition/diversion pathways in a nuclear energy system is described, including follow-up R and D plans to assess the multiplicity and robustness of barriers against proliferation

  10. Neutronic simulation calculations to assess the proliferation resistance of nuclear technologies

    International Nuclear Information System (INIS)

    Englert, Matthias

    2009-01-01

    This thesis investigates the proliferation resistance of nuclear technologies on the basis of three case studies. After a brief description of the concept of proliferation resistance the utilized computer codes and methods are presented. The first case study investigates the potential of monolithic fuel for the conversion of one-fuel-element high-flux research reactors from highly enriched to low enriched uranium using the example of the german research reactor FRM-II. The second case study assesses the proliferation potential of future tokamak based fusion reactors by using neutronic simulations of a possible plutonium production. The third example investigates the proliferation potential of spallation neutron sources to produce nuclear weapon relevant material and the proliferation resistance of such facilities. (orig.)

  11. Development of Proliferation Resistance Assessment Methodology Based on International Standards

    International Nuclear Information System (INIS)

    Lee, Yong Deok; Lee, Jung Won; Lee, Kwang Seok

    2009-03-01

    Proliferation resistance is one of the requirement to be met in GEN IV and INPRO for next generation nuclear energy system. Internationally, the evaluation methodology on PR had been already initiated from 1980, but the systematic development was started at 2000s. In Korea, for the export of nuclear energy system and the increase of international credibility and transparence of domestic nuclear system and fuel cycle development, the independent development of PR evaluation methodology was started in 2007 as a nuclear long term R and D project and the development is being performed for the model of PR evaluation methodology. In 1st year, comparative study of GEN-IV/INPRO, PR indicator development, quantification of indicator and evaluation model development, analysis of technology system and international technology development trend had been performed. In 2nd year, feasibility study of indicator, allowable limit of indicator, review of technical requirement of indicator were done. The results of PR evaluation must be applied in the beginning of conceptual design of nuclear system. Through the technology development of PR evaluation methodology, the methodology will be applied in the regulatory requirement for authorization and permission to be developed

  12. Acquisition/Diversion Pathway Analysis of the DUPIC Fuel Cycle for the Assessment of Proliferation Resistance

    International Nuclear Information System (INIS)

    Chang, Hong Lae; Ko, Won Il

    2008-01-01

    Within the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) of the IAEA, a methodology for evaluating proliferation resistance (INPRO PR methodology) has been developed in order to provide guidance in using the INPRO methodology. However, it remains to develop the methodology to evaluate User Requirements (UR) 4 regarding multiplicity and robustness of barriers against proliferation (innovative nuclear energy systems should incorporate multiple proliferation resistance features and measures). To develop the assessment procedure and metrics for User Requirement 4 (UR4), the coarse acquisition/ diversion pathway analysis of the DUPIC Fuel Cycle has been performed. The most plausible pathways for the acquisition of weapons-usable nuclear material were identified and analyzed using a systematic approach herein, and future work to complete the assessment approach for the UR4 of the INPRO methodology regarding the multiplicity and robustness of barriers against proliferation are also proposed

  13. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume II. Proliferation resistance

    International Nuclear Information System (INIS)

    1980-06-01

    The purpose of this volume is limited to an assessment of the relative effects that particular choices of nuclear-power systems, for whatever reasons, may have on the possible spread of nuclear-weapons capabilities. This volume addresses the concern that non-nuclear-weapons states may be able to initiate efforts to acquire or to improve nuclear-weapons capabilities through civilian nuclear-power programs; it also addresses the concern that subnational groups may obtain and abuse the nuclear materials or facilities of such programs, whether in nuclear-weapons states (NWS's) or nonnuclear-weapons states (NNW's). Accordingly, this volume emphasizes one important factor in such decisions, the resistance of nuclear-power systems to the proliferation of nuclear-weapons capabilities

  14. MODIFIED PATH METHODOLOGY FOR OBTAINING INTERVAL-SCALED POSTURAL ASSESSMENTS OF FARMWORKERS.

    Science.gov (United States)

    Garrison, Emma B; Dropkin, Jonathan; Russell, Rebecca; Jenkins, Paul

    2018-01-29

    Agricultural workers perform tasks that frequently require awkward and extreme postures that are associated with musculoskeletal disorders (MSDs). The PATH (Posture, Activity, Tools, Handling) system currently provides a sound methodology for quantifying workers' exposure to these awkward postures on an ordinal scale of measurement, which places restrictions on the choice of analytic methods. This study reports a modification of the PATH methodology that instead captures these postures as degrees of flexion, an interval-scaled measurement. Rather than making live observations in the field, as in PATH, the postural assessments were performed on photographs using ImageJ photo analysis software. Capturing the postures in photographs permitted more careful measurement of the degrees of flexion. The current PATH methodology requires that the observer in the field be trained in the use of PATH, whereas the single photographer used in this modification requires only sufficient training to maintain the proper camera angle. Ultimately, these interval-scale measurements could be combined with other quantitative measures, such as those produced by electromyograms (EMGs), to provide more sophisticated estimates of future risk for MSDs. Further, these data can provide a baseline from which the effects of interventions designed to reduce hazardous postures can be calculated with greater precision. Copyright© by the American Society of Agricultural Engineers.

  15. Utility of Social Modeling in Assessment of a State's Propensity for Nuclear Proliferation

    International Nuclear Information System (INIS)

    Coles, Garill A.; Brothers, Alan J.; Whitney, Paul D.; Dalton, Angela C.; Olson, Jarrod; White, Amanda M.; Cooley, Scott K.; Youchak, Paul M.; Stafford, Samuel V.

    2011-01-01

    This report is the third and final report out of a set of three reports documenting research for the U.S. Department of Energy (DOE) National Security Administration (NASA) Office of Nonproliferation Research and Development NA-22 Simulations, Algorithms, and Modeling program that investigates how social modeling can be used to improve proliferation assessment for informing nuclear security, policy, safeguards, design of nuclear systems and research decisions. Social modeling has not to have been used to any significant extent in a proliferation studies. This report focuses on the utility of social modeling as applied to the assessment of a State's propensity to develop a nuclear weapons program.

  16. Utility of Social Modeling in Assessment of a State’s Propensity for Nuclear Proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Coles, Garill A.; Brothers, Alan J.; Whitney, Paul D.; Dalton, Angela C.; Olson, Jarrod; White, Amanda M.; Cooley, Scott K.; Youchak, Paul M.; Stafford, Samuel V.

    2011-06-01

    This report is the third and final report out of a set of three reports documenting research for the U.S. Department of Energy (DOE) National Security Administration (NASA) Office of Nonproliferation Research and Development NA-22 Simulations, Algorithms, and Modeling program that investigates how social modeling can be used to improve proliferation assessment for informing nuclear security, policy, safeguards, design of nuclear systems and research decisions. Social modeling has not to have been used to any significant extent in a proliferation studies. This report focuses on the utility of social modeling as applied to the assessment of a State's propensity to develop a nuclear weapons program.

  17. Novel T lymphocyte proliferation assessment using whole mouse cryo-imaging

    Science.gov (United States)

    Wuttisarnwattana, Patiwet; Raza, Syed A.; Eid, Saada; Cooke, Kenneth R.; Wilson, David L.

    2014-03-01

    New imaging technologies enable one to assess T-cell proliferation, an important feature of the immunological response. However, none of the traditional imaging modalities allow one to examine quantiatively T-cell function with microscopic resolution and single cell sensitivity over an entire mouse. To address this need, we established T-cells proliferation assays using 3D microscopic cryo-imaging. Assays include: (1) biodistribution of T-cells, (2) secondary lymphoid organ (SLO) volume measurement, (3) carboxyfluorescein succinimidyl ester (CFSE) dilution per cell as cells divide. To demonstrate the application, a graft-versus-host-disease (GVHD) model was used. 3D visualization show that T-cells specifically homed to the SLOs (spleen and lymph nodes) as well as GVHD target organs (such as GI-tract, liver, skin and thymus).The spleen was chosen as representative of the SLOs. For spleen size analysis, volumes of red and white pulp were measured. Spleen volumes of the allogeneic mice (with GVHD) were significantly larger than those of the syngeneic mice (without GVHD) at 72 to 120 hours post-transplant. For CFSE dilution approach, we employed color-coded volume rendering and probability density function (PDF) of single cell intensity to assess T-cell proliferation in the spleen. As compared to syngeneic T-cells, the allogeneic T-cells quickly aggregated in the spleen as indicated by increasing of CFSE signal over the first 48 hours. Then they rapidly proliferated as evidenced by reduced CFSE intensity (at 48-96 hours). Results suggest that assays can be used to study GVHD treatments using T-cell proliferation and biodistibution as assays. In summary, this is the first time that we are able to track and visualize T-cells in whole mouse with single cell sensitivity. We believe that our technique can be an alternative choice to traditional in vitro immunological proliferation assays by providing assessment of proliferation in an in vivo model.

  18. Approach to proliferation risk assessment based on multiple objective analysis framework

    Energy Technology Data Exchange (ETDEWEB)

    Andrianov, A.; Kuptsov, I. [Obninsk Institute for Nuclear Power Engineering of NNRU MEPhI (Russian Federation); Studgorodok 1, Obninsk, Kaluga region, 249030 (Russian Federation)

    2013-07-01

    The approach to the assessment of proliferation risk using the methods of multi-criteria decision making and multi-objective optimization is presented. The approach allows the taking into account of the specifics features of the national nuclear infrastructure, and possible proliferation strategies (motivations, intentions, and capabilities). 3 examples of applying the approach are shown. First, the approach has been used to evaluate the attractiveness of HEU (high enriched uranium)production scenarios at a clandestine enrichment facility using centrifuge enrichment technology. Secondly, the approach has been applied to assess the attractiveness of scenarios for undeclared production of plutonium or HEU by theft of materials circulating in nuclear fuel cycle facilities and thermal reactors. Thirdly, the approach has been used to perform a comparative analysis of the structures of developing nuclear power systems based on different types of nuclear fuel cycles, the analysis being based on indicators of proliferation risk.

  19. Approach to proliferation risk assessment based on multiple objective analysis framework

    International Nuclear Information System (INIS)

    Andrianov, A.; Kuptsov, I.

    2013-01-01

    The approach to the assessment of proliferation risk using the methods of multi-criteria decision making and multi-objective optimization is presented. The approach allows the taking into account of the specifics features of the national nuclear infrastructure, and possible proliferation strategies (motivations, intentions, and capabilities). 3 examples of applying the approach are shown. First, the approach has been used to evaluate the attractiveness of HEU (high enriched uranium)production scenarios at a clandestine enrichment facility using centrifuge enrichment technology. Secondly, the approach has been applied to assess the attractiveness of scenarios for undeclared production of plutonium or HEU by theft of materials circulating in nuclear fuel cycle facilities and thermal reactors. Thirdly, the approach has been used to perform a comparative analysis of the structures of developing nuclear power systems based on different types of nuclear fuel cycles, the analysis being based on indicators of proliferation risk

  20. An approach to quantitative assessment of relative proliferation risks from nuclear fuel cycles

    International Nuclear Information System (INIS)

    Silvennoinen, P.; Vira, J.

    1981-01-01

    Feasibility of quantitative assessments of the risk of nuclear weapons proliferation is discussed in this paper. The proliferation risk is defined as a combined utility of the different fuel cycle processes or materials for the proscribed acquisition of a nuclear weapon. Based on a set of selected weighted criteria, the process utilities are calculated employing utility functions or fuzzy expectation values. The methods are compared to each other. The scheme appears feasible in relative comparisons while certain leeway must still be retained for political judgement. (author)

  1. Assessment of proliferation resistances of aqueous reprocessing techniques using the TOPS methodology

    International Nuclear Information System (INIS)

    Åberg Lindell, M.; Grape, S.; Håkansson, A.; Jacobsson Svärd, S.

    2013-01-01

    Highlights: • Proliferation resistances of three possible LFR fuel cycles are assessed. • The TOPS methodology has been chosen for the PR assessment. • Reactor operation, reprocessing and fuel fabrication are examined. • Purex, Ganex, and a combination of Purex, Diamex and Sanex, are compared. • The safeguards analysis speaks in favor of Ganex as opposed to the Purex process. - Abstract: The aim of this study is to assess and compare the proliferation resistances (PR) of three possible Generation IV lead-cooled fast reactor fuel cycles, involving the reprocessing techniques Purex, Ganex and a combination of Purex, Diamex and Sanex, respectively. The examined fuel cycle stages are reactor operation, reprocessing and fuel fabrication. The TOPS methodology has been chosen for the PR assessment, and the only threat studied is the case where a technically advanced state diverts nuclear material covertly. According to the TOPS methodology, the facilities have been divided into segments, here roughly representing the different forms of nuclear material occurring in each examined fuel cycle stage. For each segment, various proliferation barriers have been assessed. The results make it possible to pinpoint where the facilities can be improved. The results show that the proliferation resistance of a fuel cycle involving recycling of minor actinides is higher than for the traditional Purex reprocessing cycle. Furthermore, for the purpose of nuclear safeguards, group actinide extraction should be preferred over reprocessing options where pure plutonium streams occur. This is due to the fact that a solution containing minor actinides is less attractive to a proliferator than a pure Pu solution. Thus, the safeguards analysis speaks in favor of Ganex as opposed to the Purex process

  2. DEVELOPMENT OF A METHODOLOGY TO ASSESS PROLIFERATION RESISTANCE AND PHYSICAL PROTECTION FOR GENERATION IV SYSTEMS

    International Nuclear Information System (INIS)

    Nishimura, R.; Bari, R.; Peterson, P.; Roglans-Ribas, J.; Kalenchuk, D.

    2004-01-01

    Enhanced proliferation resistance and physical protection (PR and PP) is one of the technology goals for advanced nuclear concepts, such as Generation IV systems. Under the auspices of the Generation IV International Forum, the Office of Nuclear Energy, Science and Technology of the U.S. DOE, the Office of Nonproliferation Policy of the National Nuclear Security Administration, and participating organizations from six other countries are sponsoring an international working group to develop an evaluation methodology for PR and PP. This methodology will permit an objective PR and PP comparison between alternative nuclear systems (e.g., different reactor types or fuel cycles) and support design optimization to enhance robustness against proliferation, theft and sabotage. The paper summarizes the proposed assessment methodology including the assessment framework, measures used to express the PR and PP characteristics of the system, threat definition, system element and target identification, pathway identification and analysis, and estimation of the measures

  3. Framework for Proliferation Resistance and Physical Protection for Nonproliferation Impact Assessments

    International Nuclear Information System (INIS)

    Bari, R.

    2008-01-01

    This report describes a framework for proliferation resistance and physical protection evaluation for the fuel cycle systems envisioned in the expansion of nuclear power for electricity generation. The methodology is based on an approach developed as part of the Generation IV technical evaluation framework and on a qualitative evaluation approach to policy factors similar to those that were introduced in previous Nonproliferation Impact Assessments performed by DOE

  4. Assessing the intersection/remagnetization puzzle with synthetic apparent polar wander paths

    Science.gov (United States)

    Pivarunas, Anthony F.; Meert, Joseph G.; Miller, Scott R.

    2018-05-01

    Paleomagnetic data are of variable quality. To assist in a systematic assessment of data, a set of seven quality criteria (VQ1 - VQ7) were introduced by Van der Voo (1990). The last of those criteria `VQ7' concerns the possibility of remagnetization when a particular paleomagnetic pole resembles a younger paleopole from the same stable region. While remagnetizations are often the culprit, the mere resemblance of an older pole to a younger pole does not a priori require that the rocks under investigation are remagnetized. Given that the Earth has a finite surface area; that apparent polar wander paths are represented as wide swathes rather than points, and that continental motion has taken place over several billion years, we ask the question `How likely is it for an apparent polar wander path to loop back on itself?' To answer this question, we constructed synthetic apparent polar wander paths (APWPs) in an effort to evaluate the likelihood of self-intersection. We find that given 500 Myr of apparent polar wander, ˜60 per cent of the synthetic APWPs show self-intersection. Given 1000 Myr of apparent polar wander, ˜95 per cent of the synthetic APWPs show self-intersection. These results show that resemblance to younger paleopoles, over the long term, may be governed by simple probability rather than only remagnetization. We recognize that remagnetization does occur, sometimes pervasively, and must be reckoned with in the assessment of paleomagnetic data. Perhaps VQ7 should be amended to the first sentence in the original discussion (Van der Voo, 1990), and focus on satisfying `No suspicion of remagnetization' via other means rather than solely a resemblance to younger poles.

  5. On the future of civilian plutonium: An assessment of technological impediments to nuclear terrorism and proliferation

    Science.gov (United States)

    Avedon, Roger Edmond

    This dissertation addresses the value of developing diversion- and theft-resistant nuclear power technology, given uncertain future demand for nuclear power, and uncertain risks of nuclear terrorism and of proliferation from the reprocessing of civilian plutonium. The methodology comprises four elements: Economics. An economic growth model coupled with market penetration effects for plutonium and for the hypothetical new technology provides a range of estimates for future nuclear demand. A flow model accounts for the longevity of capital assets (nuclear plants) over time. Terrorism. The commercial nuclear fuel cycle may provide a source of fissile material for terrorists seeking to construct a crude nuclear device. An option value model is used to estimate the effects of the hypothetical new technology on reducing the probability of theft. A game theoretic model is used to explore the deterrence value of physical security and then to draw conclusions about how learning on the part of terrorists or security forces might affect the theft estimate. The principal uncertainties in the theft model can be updated using Bayesian techniques as new data emerge. Proliferation. Access to fissile material is the principal technical impediment to a state's acquisition of nuclear weapons. A game theoretic model is used to determine the circumstances under which a state may proliferate via diversion. The model shows that the hypothetical new technology will have little value for counter-proliferation if diversion is not a preferred proliferation method. A technology policy analysis of the choice of proliferation method establishes that diversion is unlikely to be used because it has no constituency among the important parties to the decision, namely the political leadership, the scientific establishment, and the military. Value. The decision whether to develop a diversion- and theft-resistant fuel cycle depends on the perceived value of avoiding nuclear terrorism and proliferation

  6. Update of the INPRO Collaborative Project, Proliferation Resistance and Safeguard ability Assessment (Prosta) Tools

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H. L.; Kwon, E. H.; Ahn, S. K.; Ko, W. I.; Kim, H. D. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The objectives of the INPRO Collaborative Project, Proliferation Resistance and Safeguard ability Assessment (PROSA) Tools are to make the INPRO proliferation resistance (PR) assessment methodology simpler and easier to use, to allow for different users and depths of analysis, to demonstrate the value and its usefulness of the refined assessment methodology to potential users, through a test with a reference case, and to provide input to a revision of the INPRO PR assessment manual. A summary of the project is described herein, including the procedure of PR assessment process and a case study using a SFR metal fuel manufacturing facility (SFMF) which is currently in the conceptual design phase at KAERI. The PROSA process with questionnaire approach is simpler and easier to perform that the original INPRO PR methodology with qualitative scale from 'weak' to 'very strong' to be determined by expert judgment. The PROSA process can be applied from the early stage of design showing the relationship of PR assessment to the SBD process.

  7. Scientific and Regulatory Policy Committee (SRPC) Review: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment

    Science.gov (United States)

    Increased cell proliferation is a defining feature of carcinogenesis and a central key event in the mode of action for many non-genotoxic carcinogens. Quantitative cell proliferation data thus play an important role in the safety assessment of many pharmaceutical and environment...

  8. Neutronic simulation calculations to assess the proliferation resistance of nuclear technologies; Neutronenphysikalische Simulationsrechnungen zur Proliferationsresistenz nuklearer Technologien

    Energy Technology Data Exchange (ETDEWEB)

    Englert, Matthias

    2009-07-13

    This thesis investigates the proliferation resistance of nuclear technologies on the basis of three case studies. After a brief description of the concept of proliferation resistance the utilized computer codes and methods are presented. The first case study investigates the potential of monolithic fuel for the conversion of one-fuel-element high-flux research reactors from highly enriched to low enriched uranium using the example of the german research reactor FRM-II. The second case study assesses the proliferation potential of future tokamak based fusion reactors by using neutronic simulations of a possible plutonium production. The third example investigates the proliferation potential of spallation neutron sources to produce nuclear weapon relevant material and the proliferation resistance of such facilities. (orig.)

  9. Sensitivity study of optimal CO2 emission paths using a simplified structural integrated assessment model (SIAM)

    International Nuclear Information System (INIS)

    Hasselmann, K.; Hasselmann, S.; Giering, R.; Ocana, V.; Storch, H. von

    1997-01-01

    A structurally highly simplified, globally integrated coupled climate-economic costs model SIAM (Structural Integrated Assessment Model) is used to compute optimal paths of global CO 2 emissions that minimize the net sum of climate damage and mitigation costs. It studies the sensitivity of the computed optimal emission paths. The climate module is represented by a linearized impulse-response model calibrated against a coupled ocean-atmosphere general circulation climate model and a three-dimensional global carbon-cycle model. The cost terms are presented by expressions designed with respect to input assumptions. These include the discount rates for mitigation and damage costs, the inertia of the socio-economic system, and the dependence of climate damages on the changes in temperature and the rate of change of temperature. Different assumptions regarding these parameters are believed to cause the marked divergences of existing cost-benefit analyses. The long memory of the climate system implies that very long time horizons of several hundred years need to be considered to optimize CO 2 emissions on time scales relevant for a policy of sustainable development. Cost-benefit analyses over shorter time scales of a century or two can lead to dangerous underestimates of the long term climate impact of increasing greenhouse-gas emissions. To avert a major long term global warming, CO 2 emissions need to be reduced ultimately to very low levels. This may be done slowly but should not be interpreted as providing a time cushion for inaction: the transition becomes more costly the longer the necessary mitigation policies are delayed. However, the long time horizon provides adequate flexibility for later adjustments. Short term energy conservation alone is insufficient and can be viewed only as a useful measure in support of the necessary long term transition to carbon-free energy technologies. 46 refs., 9 figs., 2 tabs

  10. Assessment of Hydrogen Sulfide Minimum Detection Limits of an Open Path Tunable Diode Laser

    Science.gov (United States)

    During June 2007, U.S. EPA conducted a feasibility study to determine whether the EPA OTM 10 measurement approach, also known as radial plume mapping (RPM), was feasible. A Boreal open-path tunable diode laser (OP-TDL) to collect path-integrated hydrogen sulfide measurements alon...

  11. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    1980-06-01

    This NASAP assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improvng the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness

  12. Performance Assessment of a Gnss-Based Troposphere Path Delay Estimation Software

    Science.gov (United States)

    Mariotti, Gilles; Avanzi, Alessandro; Graziani, Alberto; Tortora, Paolo

    2013-04-01

    Error budgets of Deep Space Radio Science experiments are heavily affected by interplanetary and Earth transmission media, that corrupt, due to their non-unitary refraction index, the radiometric information of signals coming from the spacecraft. An effective removal of these noise sources is crucial to achieve the accuracy and signal stability levels required by radio science applications. Depending on the nature of these refractions, transmission media are divided into dispersive (that consists of ionized particles, i.e. Solar Wind and Ionosphere) and non-dispersive ones (the refraction is caused by neutral particles: Earth Troposphere). While dispersive noises are successfully removed by multifrequency combinations (as for GPS with the well-known ionofree combination), the most accurate estimation of tropospheric noise is obtained using microwave radiometers (MWR). As the use of MWRs suffers from strong operational limitations (rain and heavy clouds conditions), the GNSS-based processing is still widely adopted to provide a cost-effective, all-weather condition estimation of the troposphere path delay. This work describes the development process and reports the results of a GNSS analysis code specifically aimed to the estimation of the path delays introduced by the troposphere above deep space complexes, to be used for the calibration of Range and Doppler radiometric data. The code has been developed by the Radio Science Laboratory of the University of Bologna in Forlì, and is currently in the testing phase. To this aim, the preliminary output is compared to MWR measurements and IGS TropoSINEX products in order to assess the reliability of the estimate. The software works using ionofree carrier-phase observables and is based upon a double-difference approach, in which the GNSS receiver placed nearby the Deep Space receiver acts as the rover station. Several baselines are then created with various IGS and EUREF stations (master or reference stations) in order to

  13. Assessment of a new biological complex efficacy on dysseborrhea, inflammation, and Propionibacterium acnes proliferation

    Directory of Open Access Journals (Sweden)

    Trompezinski S

    2016-08-01

    Full Text Available Sandra Trompezinski,1 Sophie Weber,1 Benoît Cadars,2 Florence Larue,1 Nathalie Ardiet,1 Marlène Chavagnac-Bonneville,2 Michèle Sayag,2 Eric Jourdan2 1NAOS, Aix-en Provence, 2Direction Scientifique Bioderma (NAOS, Lyon, France Introduction: Acne vulgaris is a common chronic inflammatory disease of the pilosebaceous unit triggered by Propionibacterium acnes. A bakuchiol, Ginkgo biloba extract, and mannitol (BGM complex has been developed to provide patients with acne with a specific dermocosmetic to be used adjunctively with conventional treatments. Objective: The aim of these studies was to assess the antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its individual compounds as well as its impact on sebum composition. Methods: The antibacterial, anti-inflammatory, and antioxidative potential of BGM complex and its compounds was assessed through in vitro, ex vivo, and clinical studies. The clinical benefit of BGM complex formulated in a cream was assessed in subjects prone to acne through sebum composition analysis and photometric assessments. Results: Results from the studies showed that the BGM complex has significant antibacterial, anti-inflammatory, and antioxidative properties. At similar concentrations, bakuchiol has up to twice the antioxidative potential than vitamin E. In subjects, BGM complex regulated the sebum composition in acne patients by increasing the level of sapienic and linolenic acid and reducing the level of oleic acid. The reduced number of porphyrins on the skin surface showed that it is also effective against P. acnes. Conclusion: BGM complex provides a complete adjunctive care in patients with acne by targeting etiopathogenic factors of acne: dysseborrhea, inflammation, and P. acnes proliferation. Keywords: acne, antibacterial, anti-inflammatory, antioxidation, cosmetics, sebum

  14. Assessment of Proliferation Resistance of Closed Nuclear Fuel Cycle System with Sodium Cooled Fast Reactors Using INPRO Evaluation Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young In; Hahn, Do Hee; Won, Byung Chool; Lee, Dong Uk

    2007-11-15

    Using the INPRO methodology, the proliferation resistance of an innovative nuclear energy system(INS) defined as a closed nuclear fuel cycle system consisting of KALIMER and pyroprocessing, has been assessed. Considering a very early development stage of the INS concept, the PR assessment is carried out based on intrinsic features, if required information and data are not available. The PR assessment of KALIMER and JSFR using the INPRO methodology affirmed that an adequate proliferation resistance has been achieved in both INSs CNFC-SFR, considering the assessor's progress and maturity of design development. KALIMER and JSFR are developed or being developed conforming to the targets and criteria defined for developing Gen IV nuclear reactor system. Based on these assessment results, proliferation resistance and physical protection(PR and PP) of KALIMER and JSFR are evaluated from the viewpoint of requirements for future nuclear fuel cycle system. The envisioned INSs CNFC-SFR rely on active plutonium management based on a closed fuel cycle, in which a fissile material is recycled in an integrated fuel cycle facility within proper safeguards. There is no isolated plutonium in the closed fuel cycle. The material remains continuously in a sequence of highly radioactive matrices within inaccessible facilities. The proliferation resistance assessment should be an ongoing analysis that keeps up with the progress and maturity of the design of Gen IV SFR.

  15. Assessment of Proliferation Resistance of Closed Nuclear Fuel Cycle System with Sodium Cooled Fast Reactors Using INPRO Evaluation Methodology

    International Nuclear Information System (INIS)

    Kim, Young In; Hahn, Do Hee; Won, Byung Chool; Lee, Dong Uk

    2007-11-01

    Using the INPRO methodology, the proliferation resistance of an innovative nuclear energy system(INS) defined as a closed nuclear fuel cycle system consisting of KALIMER and pyroprocessing, has been assessed. Considering a very early development stage of the INS concept, the PR assessment is carried out based on intrinsic features, if required information and data are not available. The PR assessment of KALIMER and JSFR using the INPRO methodology affirmed that an adequate proliferation resistance has been achieved in both INSs CNFC-SFR, considering the assessor's progress and maturity of design development. KALIMER and JSFR are developed or being developed conforming to the targets and criteria defined for developing Gen IV nuclear reactor system. Based on these assessment results, proliferation resistance and physical protection(PR and PP) of KALIMER and JSFR are evaluated from the viewpoint of requirements for future nuclear fuel cycle system. The envisioned INSs CNFC-SFR rely on active plutonium management based on a closed fuel cycle, in which a fissile material is recycled in an integrated fuel cycle facility within proper safeguards. There is no isolated plutonium in the closed fuel cycle. The material remains continuously in a sequence of highly radioactive matrices within inaccessible facilities. The proliferation resistance assessment should be an ongoing analysis that keeps up with the progress and maturity of the design of Gen IV SFR

  16. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    1979-12-01

    This assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improving the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness. The objectives of this assessment are to identify when economic incentives to deploy advanced nuclear power systems might exist, to estimate the costs of using technologies that would reduce the risk of proliferation, to assess the impact of major economic uncertainties on the transition to new technologies, and to compare the investments required for alternative systems. This information can then be used to assess the potential economic benefits of alternative research, development, and demonstration programs and the timing of those programs

  17. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume V. Economics and systems analysis

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-12-01

    This assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improving the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness. The objectives of this assessment are to identify when economic incentives to deploy advanced nuclear power systems might exist, to estimate the costs of using technologies that would reduce the risk of proliferation, to assess the impact of major economic uncertainties on the transition to new technologies, and to compare the investments required for alternative systems. This information can then be used to assess the potential economic benefits of alternative research, development, and demonstration programs and the timing of those programs.

  18. Using the Curriculum Vita To Study the Career Paths of Scientists and Engineers: An Assessment.

    Science.gov (United States)

    Lane, Eliesh O'Neil; Dietz, James S.; Chompalov, Ivan; Bozeman, Barry; Park, Jongwon

    The usefulness of the curriculum vita (CV) as a data source for examining the career paths of scientists and engineers was studied. CVs were obtained in response to an e-mail message sent to researchers working in the area of biotechnology who were funded by the National Science Foundation (55 responses) or listed as authors (industry only) in the…

  19. Nuclear proliferation and civilian nuclear power: report of the nonproliferation alternative systems assessment program. Volume V. Economics and systems analysis

    International Nuclear Information System (INIS)

    1979-12-01

    This NASAP assessment considers the economics of alternative nuclear reactor and fuel-cycle systems in the light of possible patterns of uranium supply and energy demand, as well as the economic implications of improving the proliferation resistance of the various systems. The assessment focuses on the costs of alternative nuclear technologies and the possible timing of their implementation, based on their economic attractiveness. The objectives of this assessment are to identify when economic incentives to deploy advanced nuclear power systems might exist, to estimate the costs of using technologies that would reduce the risk of proliferation, to assess the impact of major economic uncertainties on the transition to new technologies, and to compare the investments required for alternative systems

  20. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP.

  1. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume 1. Program summary

    International Nuclear Information System (INIS)

    1979-12-01

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. This introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings and recommendations. Each of Volumes II-VII reports on an individual assessment (Volume II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

  2. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume I. Program summary

    International Nuclear Information System (INIS)

    1980-06-01

    This report summarizes the Nonproliferation Alternative Systems Assessment Program (NASAP): its background, its studies, and its results. The introductory chapter traces the growth of the issue of nuclear weapons proliferation and the organization and objectives of NASAP. Chapter 2 summarizes the program's assessments, findings, and recommendations. Each of Volumes II-VII reports on an individual assessment (Volumn II: Proliferation Resistance; Volume III: Resources and Fuel Cycle Facilities; Volume IV: Commercial Potential; Volume V: Economics and Systems Analysis; Volume VI: Safety and Environmental Considerations for Licensing; Volume VII: International Perspectives). Volume VIII (Advanced Concepts) presents a combined assessment of several less fully developed concepts, and Volume IX (Reactor and Fuel Cycle Descriptions) provides detailed descriptions of the reactor and fuel-cycle systems studied by NASAP

  3. Assessment of nuclear fuel cycles with respect to assurance of energy supply; economic aspects; environmental aspects; non-proliferation

    International Nuclear Information System (INIS)

    1979-01-01

    This paper, which was presented to all INFCE Working Groups gives a broad qualitative assessment in tabular form of the following five fuel cycles: LWR once-through, LWR with thermal recycle, HWR once-through, HTR with uranium recycle, fast breeder reactor. The assessment is given of the assurance of supply aspects, the macro- and micro-economic aspects, the environmental aspects, and the non-proliferation, including safeguards, aspects of each fuel cycle

  4. Path Dependency

    OpenAIRE

    Mark Setterfield

    2015-01-01

    Path dependency is defined, and three different specific concepts of path dependency – cumulative causation, lock in, and hysteresis – are analyzed. The relationships between path dependency and equilibrium, and path dependency and fundamental uncertainty are also discussed. Finally, a typology of dynamical systems is developed to clarify these relationships.

  5. Inter-rater reliability of PATH observations for assessment of ergonomic risk factors in hospital work.

    Science.gov (United States)

    Park, Jung-Keun; Boyer, Jon; Tessler, Jamie; Casey, Jeffrey; Schemm, Linda; Gore, Rebecca; Punnett, Laura

    2009-07-01

    This study examined the inter-rater reliability of expert observations of ergonomic risk factors by four analysts. Ten jobs were observed at a hospital using a newly expanded version of the PATH method (Buchholz et al. 1996), to which selected upper extremity exposures had been added. Two of the four raters simultaneously observed each worker onsite for a total of 443 observation pairs containing 18 categorical exposure items each. For most exposure items, kappa coefficients were 0.4 or higher. For some items, agreement was higher both for the jobs with less rapid hand activity and for the analysts with a higher level of ergonomic job analysis experience. These upper extremity exposures could be characterised reliably with real-time observation, given adequate experience and training of the observers. The revised version of PATH is applicable to the analysis of jobs where upper extremity musculoskeletal strain is of concern.

  6. Final Environmental Assessment for Shared Use Paths (SUP), Eglin Air Force Base, Florida

    Science.gov (United States)

    2011-07-01

    social effects...Use Path (SUP)Environmental AssesmentEglin Air Force Base, Florida "/ "/ "/ "/ "/ "/ "/ "/ "/ "/ "/ Eighth StEglin Blvd Memoria l Dr Griffin Way...StEglin Blvd Memoria l Dr Griffin Way Nomad Way Eglin B lvd FL HW Y 8 5 Chinquapin Dr Perimeter Rd VALPARISO Park Tunn el Taxiw ay PT A rea Com miss

  7. Assessment of Masonry Buildings Subjected to Landslide-Induced Settlements: From Load Path Method to Evolutionary Optimization Method

    Science.gov (United States)

    Palmisano, Fabrizio; Elia, Angelo

    2017-10-01

    One of the main difficulties, when dealing with landslide structural vulnerability, is the diagnosis of the causes of crack patterns. This is also due to the excessive complexity of models based on classical structural mechanics that makes them inappropriate especially when there is the necessity to perform a rapid vulnerability assessment at the territorial scale. This is why, a new approach, based on a ‘simple model’ (i.e. the Load Path Method, LPM), has been proposed by Palmisano and Elia for the interpretation of the behaviour of masonry buildings subjected to landslide-induced settlements. However, the LPM is very useful for rapidly finding the 'most plausible solution' instead of the exact solution. To find the solution, optimization algorithms are necessary. In this scenario, this article aims to show how the Bidirectional Evolutionary Structural Optimization method by Huang and Xie, can be very useful to optimize the strut-and-tie models obtained by using the Load Path Method.

  8. A Path Walkability Assessment Index Model for Evaluating and Facilitating Retail Walking Using Decision-Tree-Making (DTM Method

    Directory of Open Access Journals (Sweden)

    Ali Keyvanfar

    2018-03-01

    Full Text Available Transportation is the major contributor of ever-increasing CO2 and Greenhouse Gas emissions in cities. The ever-increasing hazardous emissions of transportation and energy consumption have persuaded transportation and urban planners to motivate people to non-motorized mode of travel, especially walking. Currently, there are several urban walkability assessment models; however, coping with a limited range of walkability assessment variables make these models not fully able to promote inclusive walkable urban neighborhoods. In this regard, this study develops the path walkability assessment (PWA index model which evaluates and analyzes path walkability in association with the pedestrian’s decision-tree-making (DTM. The model converts the pedestrian’s DTM qualitative data to quantifiable values. This model involves ninety-two (92 physical and environmental walkability assessment variables clustered into three layers of DTM (Layer 1: features; Layer 2: Criteria; and Layer 3: Sub-Criteria, and scoped to shopping and retail type of walking. The PWA model as a global decision support tool can be applied in any neighborhood in the world, and this study implements it at Taman Universiti neighborhood in Skudai, Malaysia. The PWA model has established the walkability score index which determines the grading rate of walkability accomplishment for each walkability variable of the under-survey neighborhood. Using the PWA grading index enables urban designers to manage properly the financial resource allocation for inspiring walkability in the targeted neighborhood.

  9. Assessment of the beryllium lymphocyte proliferation test using statistical process control.

    Science.gov (United States)

    Cher, Daniel J; Deubner, David C; Kelsh, Michael A; Chapman, Pamela S; Ray, Rose M

    2006-10-01

    Despite more than 20 years of surveillance and epidemiologic studies using the beryllium blood lymphocyte proliferation test (BeBLPT) as a measure of beryllium sensitization (BeS) and as an aid for diagnosing subclinical chronic beryllium disease (CBD), improvements in specific understanding of the inhalation toxicology of CBD have been limited. Although epidemiologic data suggest that BeS and CBD risks vary by process/work activity, it has proven difficult to reach specific conclusions regarding the dose-response relationship between workplace beryllium exposure and BeS or subclinical CBD. One possible reason for this uncertainty could be misclassification of BeS resulting from variation in BeBLPT testing performance. The reliability of the BeBLPT, a biological assay that measures beryllium sensitization, is unknown. To assess the performance of four laboratories that conducted this test, we used data from a medical surveillance program that offered testing for beryllium sensitization with the BeBLPT. The study population was workers exposed to beryllium at various facilities over a 10-year period (1992-2001). Workers with abnormal results were offered diagnostic workups for CBD. Our analyses used a standard statistical technique, statistical process control (SPC), to evaluate test reliability. The study design involved a repeated measures analysis of BeBLPT results generated from the company-wide, longitudinal testing. Analytical methods included use of (1) statistical process control charts that examined temporal patterns of variation for the stimulation index, a measure of cell reactivity to beryllium; (2) correlation analysis that compared prior perceptions of BeBLPT instability to the statistical measures of test variation; and (3) assessment of the variation in the proportion of missing test results and how time periods with more missing data influenced SPC findings. During the period of this study, all laboratories displayed variation in test results that

  10. Assessing the optimism-pessimism debate: Nuclear proliferation, nuclear risks, and theories of state action

    International Nuclear Information System (INIS)

    Busch, Nathan Edward

    2001-01-01

    This dissertation focuses on the current debate in international relations literature over the risks associated with the proliferation of nuclear weapons. On this subject, IR scholars are divided into roughly two schools: proliferation 'optimists,' who argue that proliferation can be beneficial and that its associated hazards are at least surmountable, and proliferation 'pessimists,' who believe the opposite. This debate centers upon a theoretical disagreement about how best to explain and predict the behavior of states. Optimists generally ground their arguments on rational deterrence theory and maintain that nuclear weapons can actually increase stability among states, while pessimists often ground their arguments on 'organization theory,' which contends that organizational, bureaucratic, and other factors prevent states from acting rationally. A major difficulty with the proliferation debate, however, is that both sides tend to advance their respective theoretical positions without adequately supporting them with solid empirical evidence. This dissertation detailed analyses of the nuclear programs in the United States, Russia, China, India, and Pakistan to determine whether countries with nuclear weapons have adequate controls over their nuclear arsenals and tissue material stockpiles (such as highly enriched uranium and plutonium). These case studies identify the strengths and weaknesses of different systems of nuclear controls and help predict what types of controls proliferating states are likely to employ. On the basis of the evidence gathered from these cases, this dissertation concludes that a further spread of nuclear weapons would tend to have seriously negative effects on international stability by increasing risks of accidental, unauthorized, or inadvertent use of nuclear weapons and risks of thefts of fissile materials for use in nuclear or radiological devices by aspiring nuclear states or terrorist groups. (author)

  11. Neutronics calculations for denatured molten salt reactors: Assessing resource requirements and proliferation-risk attributes

    International Nuclear Information System (INIS)

    Ahmad, Ali; McClamrock, Edward B.; Glaser, Alexander

    2015-01-01

    Highlights: • We study the proliferation-risk and resource attributes of denatured MSRs. • MSRs offer significantly better resource efficiency compared to light-water reactors. • Denatured single-fluid MSRs reactors offer promising non-proliferation attributes. - Abstract: Molten salt reactors (MSRs) are often advocated as a radical but worthwhile alternative to traditional reactor concepts based on solid fuels. This article builds upon the existing research into MSRs to model and simulate the operation of thorium-fueled single-fluid and two-fluid reactors. The analysis is based on neutronics calculations and focuses on denatured MSR systems. Resource utilization and basic proliferation-risk attributes are compared to those of standard light-water reactors. Depending on specific design choices, even fully denatured reactors could reduce uranium and enrichment requirements by a factor of 3–4. Overall, denatured single-fluid designs appear as the most promising candidate technology minimizing both design complexity and overall proliferation risks despite being somewhat less attractive from the perspective of resource utilization

  12. Assessment of the Dominant Path Model and Field Measurements for NLOS DTV Signal Propagation

    Science.gov (United States)

    Adonias, Geoflly L.; Carvalho, Joabson N.

    2018-03-01

    In Brazil, one of the most important telecommunications systems is broadcast television. Such relevance demands an extensive analysis to be performed chasing technical excellence in order to offer a better digital transmission to the user. Therefore, it is mandatory to evaluate the quality and strength of the Digital TV signal, through studies of coverage predictions models, allowing stations to be projected in a way that their respective signals are harmoniously distributed. The purpose of this study is to appraise measurements of digital television signal obtained in the field and to compare them with numerical results from the simulation of the Dominant Path Model. The outcomes indicate possible blocking zones and a low accumulated probability index above the reception threshold, as well as characterise the gain level of the receiving antenna, which would prevent signal blocking.

  13. A Review on Investigation and Assessment of Path Loss Models in Urban and Rural Environment

    Science.gov (United States)

    Maurya, G. R.; Kokate, P. A.; Lokhande, S. K.; Shrawankar, J. A.

    2017-08-01

    This paper aims at providing a clear knowledge of Path Loss (PL) to the researcher. The important data have been extracted from the papers and mentioned in clear and precise manner. The limited studies were based on identification of PL due to FM frequency. Majority of studies based on identification of PL considering telephonic frequency as a source. In this paper the PL in urban and rural areas of different places due to various factors like buildings, trees, antenna height, forest etc. have been studied. The common parameters like frequency, model and location based studies were done. The studies were segregated based on various parameters in tabular format and they were compared based on frequency, location and best fit model in that table. Scatter chart was drawn in order to make the things clearer and more understandable. However, location specific PL models are required to investigate the RF propagation in identified terrain.

  14. Fissile material proliferation risk

    International Nuclear Information System (INIS)

    Dreicer, J.S.; Rutherford, D.A.

    1996-01-01

    The proliferation risk of a facility depends on the material attractiveness, level of safeguards, and physical protection applied to the material in conjunction with an assessment of the impact of the socioeconomic circumstances and threat environment. Proliferation risk is a complementary extension of proliferation resistance. The authors believe a better determination of nuclear proliferation can be achieved by establishing the proliferation risk for facilities that contain nuclear material. Developing a method that incorporates the socioeconomic circumstances and threat environment inherent to each country enables a global proliferation assessment. To effectively reduce the nuclear danger, a broadly based set of criteria is needed that provides the capability to relatively assess a wide range of nuclear related sites and facilities in different countries and still ensure a global decrease in proliferation risk for fissile material (plutonium and highly enriched uranium)

  15. Bats Use Path Integration Rather Than Acoustic Flow to Assess Flight Distance along Flyways.

    Science.gov (United States)

    Aharon, Gal; Sadot, Meshi; Yovel, Yossi

    2017-12-04

    Navigation can be achieved using different strategies from simple beaconing to complex map-based movement [1-4]. Bats display remarkable navigation capabilities, ranging from nightly commutes of several kilometers and up to seasonal migrations over thousands of kilometers [5]. Many bats have been suggested to fly along fixed routes termed "flyways," when flying from their roost to their foraging sites [6]. Flyways commonly stretch along linear landscape elements such as tree lines, hedges, or rivers [7]. When flying along a flyway, bats must estimate the distance they have traveled in order to determine when to turn. This can be especially challenging when moving along a repetitive landscape. Some bats, like Kuhl's pipistrelles, which we studied here, have limited vision [8] and were suggested to rely on bio-sonar for navigation. These bats could therefore estimate distance using three main sensory-navigation strategies, all of which we have examined: acoustic flow, acoustic landmarks, or path integration. We trained bats to fly along a linear flyway and land on a platform. We then tested their behavior when the platform was removed under different manipulations, including changing the acoustic flow, moving the start point, and adding wind. We found that bats do not require acoustic flow, which was hypothesized to be important for their navigation [9-15], and that they can perform the task without landmarks. Our results suggest that Kuhl's pipistrelles use internal self-motion cues-also known as path integration-rather than external information to estimate flight distance for at least dozens of meters when navigating along linear flyways. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. A Comparison of the Safety Analysis Process and the Generation IV Proliferation Resistance/Physical Protection Assessment Methodology

    International Nuclear Information System (INIS)

    T. A. Bjornard; M. D. Zentner

    2006-01-01

    The Generation IV International Forum (GIF) is a vehicle for the cooperative international development of future nuclear energy systems. The Generation IV program has established primary objectives in the areas of sustainability, economics, safety and reliability, and Proliferation Resistance and Physical Protection (PR and PP). In order to help meet the latter objective a program was launched in December 2002 to develop a rigorous means to assess nuclear energy systems with respect to PR and PP. The study of Physical Protection of a facility is a relatively well established methodology, but an approach to evaluate the Proliferation Resistance of a nuclear fuel cycle is not. This paper will examine the Proliferation Resistance (PR) evaluation methodology being developed by the PR group, which is largely a new approach and compare it to generally accepted nuclear facility safety evaluation methodologies. Safety evaluation methods have been the subjects of decades of development and use. Further, safety design and analysis is fairly broadly understood, as well as being the subject of federally mandated procedures and requirements. It is therefore extremely instructive to compare and contrast the proposed new PR evaluation methodology process with that used in safety analysis. By so doing, instructive and useful conclusions can be derived from the comparison that will help to strengthen the PR methodological approach as it is developed further. From the comparison made in this paper it is evident that there are very strong parallels between the two processes. Most importantly, it is clear that the proliferation resistance aspects of nuclear energy systems are best considered beginning at the very outset of the design process. Only in this way can the designer identify and cost effectively incorporate intrinsic features that might be difficult to implement at some later stage. Also, just like safety, the process to implement proliferation resistance should be a dynamic

  17. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations.

  18. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    International Nuclear Information System (INIS)

    1980-06-01

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations

  19. Solution Monitoring Evaluated by Proliferation Risk Assessment and Fuzzy Optimization Analysis for Safeguards in a Reprocessing Process

    Directory of Open Access Journals (Sweden)

    Mitsutoshi Suzuki

    2013-01-01

    Full Text Available Solution monitoring (SM has been used in a nuclear reprocessing plant as an additional measure to provide assurance that the plant is operated as declared. The inline volume and density monitoring equipment with dip tubes is important for safety and safeguards purposes and is a typical example of safeguards by design (SBD. Recently safety, safeguards, and security by design (3SBD are proposed to promote an efficient and effective generation of nuclear energy. In 3SBD, proliferation risk assessment has the potential to consider likelihood of the incidence and proliferation risk in safeguards. In this study, risk assessment methodologies for safeguards and security are discussed and several mathematical methods are presented to investigate risk notion applied to intentional acts of facility misuse in an uncertainty environment. Proliferation risk analysis with the Markov model, deterrence effect with the game model, and SBD with fuzzy optimization are shown in feasibility studies to investigate the potential application of the risk and uncertainty analyses in safeguards. It is demonstrated that the SM is an effective measurement system using risk-informed and cost-effective SBD, even though there are inherent difficulties related to the possibility of operator’s falsification.

  20. AN ANALYTICAL FRAMEWORK FOR ASSESSING RELIABLE NUCLEAR FUEL SERVICE APPROACHES: ECONOMIC AND NON-PROLIFERATION MERITS OF NUCLEAR FUEL LEASING

    International Nuclear Information System (INIS)

    Kreyling, Sean J.; Brothers, Alan J.; Short, Steven M.; Phillips, Jon R.; Weimar, Mark R.

    2010-01-01

    The goal of international nuclear policy since the dawn of nuclear power has been the peaceful expansion of nuclear energy while controlling the spread of enrichment and reprocessing technology. Numerous initiatives undertaken in the intervening decades to develop international agreements on providing nuclear fuel supply assurances, or reliable nuclear fuel services (RNFS) attempted to control the spread of sensitive nuclear materials and technology. In order to inform the international debate and the development of government policy, PNNL has been developing an analytical framework to holistically evaluate the economics and non-proliferation merits of alternative approaches to managing the nuclear fuel cycle (i.e., cradle-to-grave). This paper provides an overview of the analytical framework and discusses preliminary results of an economic assessment of one RNFS approach: full-service nuclear fuel leasing. The specific focus of this paper is the metrics under development to systematically evaluate the non-proliferation merits of fuel-cycle management alternatives. Also discussed is the utility of an integrated assessment of the economics and non-proliferation merits of nuclear fuel leasing.

  1. Hindlimb unloading in rat decreases preosteoblast proliferation assessed in vivo with BrdU incorporation.

    Science.gov (United States)

    Barou, O; Palle, S; Vico, L; Alexandre, C; Lafage-Proust, M H

    1998-01-01

    Immobilization affects bone formation. However, the mechanisms regulating the decrease in osteoblast recruitment remain unclear. The aim of our study was to determine in vivo osteoblastic proliferation after short-term immobilization among the different bone compartments. Twelve Wistar 5-wk-old rats were assigned to two groups: six tail-suspended animals for 6 days and their six age-related controls. Osmotic minipumps, each containing 40 mg of bromodeoxyuridine (BrdU), were implanted intraperitoneally at day 4 until euthanasia. Histomorphometric measurements found a significantly lower bone volume in primary (ISP, -22%) and secondary spongiosa (IISP, -37%) in unloaded rats compared with their age-related controls. BrdU immunohistochemistry showed that the proliferation capacity of osteogenic precursors in ISP (-29%) and preosteoblasts in IISP (-80%) and in periosteum as well as bone marrow cells (-40%) was lowered by unloading. We demonstrated in vivo for the first time that 6-day tail suspension induced a significant decrease in proliferation of periosteal and trabecular preosteoblasts in ISP and IISP as well as in bone marrow cells.

  2. Path Expressions

    Science.gov (United States)

    1975-06-01

    Traditionally, synchronization of concurrent processes is coded in line by operations on semaphores or similar objects. Path expressions move the...discussion about a variety of synchronization primitives . An analysis of their relative power is found in [3]. Path expressions do not introduce yet...another synchronization primitive . A path expression relates to such primitives as a for- or while-statement of an ALGOL-like language relates to a JUMP

  3. The role of Ki67 proliferation assessment in predicting local control in bladder cancer patients treated by radical radiation therapy

    International Nuclear Information System (INIS)

    Lara, P.C.; Gonzalez, G.; Rey, A.; Apolinario, R.; Santana, C.; Afonso, J.L.; Diaz, J.M.

    1998-01-01

    Purpose: To assess whether tumour proliferation as measured by Ki67 immunostaining has any predictive value for local control in bladder cancer patients treated by radiotherapy. Patients and methods: Fifty-five patients suffering from infiltrating bladder carcinoma recommended for radical radiotherapy (66 Gy/6-7weeks) were included in this study. Paraffin-embedded pre-treatment tumour sections were stained with the Ki67 antibody. The percentage of Ki67-positive nuclei was correlated with established prognostic factors, local control and survival. Results27%) Ki67 expression indices (31.5%) (P<0.05; log-rank test). Conclusions: Ki67 immunostaining was a feasible method to estimate tumour proliferation. Patients with very low proliferating tumours seemed to achieve better local control after fractionated radiotherapy compared to other patients. Further studies are needed with a greater number of patients to accurately define the role of Ki67 expression in predicting tumour repopulation during fractionated radiotherapy. (Copyright (c) 1998 Elsevier Science B.V., Amsterdam. All rights reserved.)

  4. Assessing modelled spatial distributions of ice water path using satellite data

    Science.gov (United States)

    Eliasson, S.; Buehler, S. A.; Milz, M.; Eriksson, P.; John, V. O.

    2010-05-01

    The climate models used in the IPCC AR4 show large differences in monthly mean cloud ice. The most valuable source of information that can be used to potentially constrain the models is global satellite data. For this, the data sets must be long enough to capture the inter-annual variability of Ice Water Path (IWP). PATMOS-x was used together with ISCCP for the annual cycle evaluation in Fig. 7 while ECHAM-5 was used for the correlation with other models in Table 3. A clear distinction between ice categories in satellite retrievals, as desired from a model point of view, is currently impossible. However, long-term satellite data sets may still be used to indicate the climatology of IWP spatial distribution. We evaluated satellite data sets from CloudSat, PATMOS-x, ISCCP, MODIS and MSPPS in terms of monthly mean IWP, to determine which data sets can be used to evaluate the climate models. IWP data from CloudSat cloud profiling radar provides the most advanced data set on clouds. As CloudSat data are too short to evaluate the model data directly, it was mainly used here to evaluate IWP from the other satellite data sets. ISCCP and MSPPS were shown to have comparatively low IWP values. ISCCP shows particularly low values in the tropics, while MSPPS has particularly low values outside the tropics. MODIS and PATMOS-x were in closest agreement with CloudSat in terms of magnitude and spatial distribution, with MODIS being the best of the two. As PATMOS-x extends over more than 25 years and is in fairly close agreement with CloudSat, it was chosen as the reference data set for the model evaluation. In general there are large discrepancies between the individual climate models, and all of the models show problems in reproducing the observed spatial distribution of cloud-ice. Comparisons consistently showed that ECHAM-5 is the GCM from IPCC AR4 closest to satellite observations.

  5. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VII. International perspectives

    International Nuclear Information System (INIS)

    1979-12-01

    The purpose of this volume is to assess the proliferation vulnerabilities of the present deployment of civilian nuclear-power systems within the current nonproliferation regime and, in light of their prospective deployment, to consider technical and institutional measures and alternatives which may contribute to an improved regime in which nuclear power could play a significant part. An assessment of these measures must include consideration of their nonproliferation effectiveness as well as their bearing upon energy security, and their operational, economic, and political implications. The nature of these considerations can provide some measure of their likely acceptability to various nations. While any final assessment of such measures and alternatives would have to examine the circumstances particular to each nation, it is hoped that the more generic assessments conducted here will be useful in suggesting guidelines for developing an improved nonproliferation regime which also helps to meet nuclear-energy needs. One chapter outlines the existing nonproliferation regime, including the Treaty for the Non-Proliferation of Nuclear Weapons (NPT), International Atomic Energy Agency (IAEA) safeguards, bilateral and multilateral requirements for agreements of cooperation and transfers of technology, and existing provisons for sanctions for violation of nonproliferation commitments. The chapter then proceeds to an assessment of various alternatives for providing assurance of fuel supply in light of this current regime. Another chapter examines a set of technical and institutional measures and alternatives for various components of once-through and closed fuel cycles. The components of the once-through fuel cycle assessed are enrichment services and spent-fuel management; the components of closed fuel cycles assessed are reprocessing and plutonium management and fast-breeder reactor (FBR) deployment

  6. Pathway Aggregation in the Risk Assessment of Proliferation Resistance and Physical Protection (PR&PP) of Nuclear Energy Systems

    International Nuclear Information System (INIS)

    2015-01-01

    The framework for Proliferation Resistance and Physical Protection (PR & PP) evaluation is to define a set of challenges, to obtain the system responses, and to assess the outcomes. The assessment of outcomes heavily relies on pathways, defined as sequences of events or actions that could potentially be followed by a State or a group of individuals in order to achieve a proliferation objective, with the defined threats as initiating events. There may be large number of segments connecting pathway stages (e.g. acquisition, processing, and fabrication for PR) which can lead to even larger number of pathways or scenarios through possible different combinations of segment connections, each with associated probabilities contributing to the overall risk. Clustering of these scenarios in specified stage attribute intervals is important for their tractable analysis and outcome assessment. A software tool for scenario generation and clustering (OSUPR) is developed that utilizes the PRCALC code developed at the Brookhaven National Laboratory for scenario generation and the K- means, mean shift and adaptive mean shift algorithms as possible clustering schemes. The results of the study using the Example Sodium Fast Breeder as an example system show that clustering facilitates the probabilistic or deterministic analysis of scenarios to identify system vulnerabilities and communication of the major risk contributors to stakeholders. The results of the study also show that the mean shift algorithm has the most potential for assisting the analysis of the scenarios generated by PRCALC.

  7. Pathway Aggregation in the Risk Assessment of Proliferation Resistance and Physical Protection (PR&PP) of Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Aldemir, Tunc [Ohio State Univ., Columbus, OH (United States); Denning, Richard [Ohio State Univ., Columbus, OH (United States); Catalyurek, Umit [Ohio State Univ., Columbus, OH (United States); Yilmaz, Alper [Ohio State Univ., Columbus, OH (United States); Yue, Meng [Brookhaven National Lab. (BNL), Upton, NY (United States); Cheng, Lap-Yan [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-01-23

    The framework for Proliferation Resistance and Physical Protection (PR & PP) evaluation is to define a set of challenges, to obtain the system responses, and to assess the outcomes. The assessment of outcomes heavily relies on pathways, defined as sequences of events or actions that could potentially be followed by a State or a group of individuals in order to achieve a proliferation objective, with the defined threats as initiating events. There may be large number of segments connecting pathway stages (e.g. acquisition, processing, and fabrication for PR) which can lead to even larger number of pathways or scenarios through possible different combinations of segment connections, each with associated probabilities contributing to the overall risk. Clustering of these scenarios in specified stage attribute intervals is important for their tractable analysis and outcome assessment. A software tool for scenario generation and clustering (OSUPR) is developed that utilizes the PRCALC code developed at the Brookhaven National Laboratory for scenario generation and the K- means, mean shift and adaptive mean shift algorithms as possible clustering schemes. The results of the study using the Example Sodium Fast Breeder as an example system show that clustering facilitates the probabilistic or deterministic analysis of scenarios to identify system vulnerabilities and communication of the major risk contributors to stakeholders. The results of the study also show that the mean shift algorithm has the most potential for assisting the analysis of the scenarios generated by PRCALC.

  8. Acoustic assessment of wood quality of raw forest materials : a path to increased profitability

    Science.gov (United States)

    Xiping Wang; Peter Carter; Robert J. Ross; Brian K. Brashaw

    2007-01-01

    Assessment of the quality of raw wood materials has become a crucial issue in the operational value chain as forestry and the wood processing industry are increasingly under economic pressure to maximize extracted value. A significant effort has been devoted toward developing robust nondestructive evaluation (NDE) technologies capable of predicting the intrinsic wood...

  9. Scenario-based roadmapping assessing nuclear technology development paths for future nuclear energy system scenarios

    International Nuclear Information System (INIS)

    Van Den Durpel, Luc; Roelofs, Ferry; Yacout, Abdellatif

    2009-01-01

    Nuclear energy may play a significant role in a future sustainable energy mix. The transition from today's nuclear energy system towards a future more sustainable nuclear energy system will be dictated by technology availability, energy market competitiveness and capability to achieve sustainability through the nuclear fuel cycle. Various scenarios have been investigated worldwide each with a diverse set of assumptions on the timing and characteristics of new nuclear energy systems. Scenario-based roadmapping combines the dynamic scenario-analysis of nuclear energy systems' futures with the technology roadmap information published and analysed in various technology assessment reports though integrated within the nuclear technology roadmap Nuclear-Roadmap.net. The advantages of this combination is to allow mutual improvement of scenario analysis and nuclear technology roadmapping providing a higher degree of confidence in the assessment of nuclear energy system futures. This paper provides a description of scenario-based roadmapping based on DANESS and Nuclear-Roadmap.net. (author)

  10. Assessment of the proliferation status of glioblastoma cell and tumour tissue after nanoplatinum treatment

    DEFF Research Database (Denmark)

    Kutwin, Marta; Sawosz, Ewa; Jaworski, Slawomir

    2017-01-01

    nanoparticles (NP-Pt). The aim of the study was to evaluate and compare the antiproliferative properties of NP-Pt and cisplatin against U87 and U118 glioma cell lines and U87 tumour tissue. NP-Pt and cisplatin were incubated with U87 and U118 glioma cells or administered directly into glioma tumour tissue. Cell...... and the migration of cancer cells but also downregulated the level of PCNA protein expression in tumour tissue. Furthermore, NP-Pt caused oxidative DNA damage in tumour tissue to a higher degree than cisplatin. Consequently, NP-Pt can be considered as an effective inhibitor of glioblastoma tumour cell proliferation....... However, the mechanism of action and potential side effects need to be elucidated further...

  11. EMAIL MARKETING CAMPAIGNS: THE EASIEST PATH FROM ORGANIZATIONS TO CONSUMERS – AN EXPLORATORY ASSESSMENT

    Directory of Open Access Journals (Sweden)

    Pantea Carmen

    2010-07-01

    Full Text Available The email is a valuable marketing tool for conveying short, simple messages that call for action on behalf of the recipient. Usually companies develop email marketing campaigns for attracting new customers, persuading the existing customers to buy again, encourage customer loyalty, announce or remind about special offers or events. For an email marketing campaign to be efficient, it is wanted a greater number of responses from those in the target. The paper assesses in an exploratory manner the frequency in using the email accounts, the level of exposure to email marketing campaigns as well as the type of information wanted to be received by the Romanian users.

  12. Bridging the divide between theory and guidance in strategic environmental assessment: A path for Italian regions

    International Nuclear Information System (INIS)

    Baresi, Umberto; Vella, Karen J.; Sipe, Neil G.

    2017-01-01

    Clear and effective legislation is a requisite to bring sustainable development from theory into practice. This paper develops a methodology to investigate how Italian regional legislation disciplines the use of Strategic Environmental Assessment (SEA), the procedure used in the European Union (EU) to pursue sustainable development of policies, plans, and programs (PPPs). Our case study is the Italian regional level, examined to identify eventual flaws and areas for improvement for each regional legislative framework. For this purpose, this study refers to a selection of analytical criteria recurring in the international debate on sustainability assessments. Statistical multi-dimensional analysis is used to identify Italian regions with similar SEA legislation. We recognize four taxonomies, depending on the way regional legislation provides information about i) legislation and guidelines, ii) integration between SEA and PPPs, iii) sustainability goals, iv) technical organization, v) participatory organization, and vi) monitoring. The results suggest that Italian administrators should cooperate to improve legislation at the regional level. Acknowledging the institution-centred nature of SEA, this methodology could drive the EU to better support SEA development in countries with diversified traditions.

  13. Bridging the divide between theory and guidance in strategic environmental assessment: A path for Italian regions

    Energy Technology Data Exchange (ETDEWEB)

    Baresi, Umberto, E-mail: u.baresi@uq.edu.au [School of Geography, Planning and Environmental Management, The University of Queensland, Level 5, Building 35, The University of Queensland, Brisbane 4072 (Australia); Vella, Karen J., E-mail: karen.vella@qut.edu.au [School of Civil Engineering and Built Environment, Queensland University of Technology, Level 8, Block S, Queensland University of Technology, Brisbane 4000 (Australia); Sipe, Neil G., E-mail: n.sipe@uq.edu.au [School of Geography, Planning and Environmental Management, The University of Queensland, Level 5, Building 35, The University of Queensland, Brisbane 4072 (Australia)

    2017-01-15

    Clear and effective legislation is a requisite to bring sustainable development from theory into practice. This paper develops a methodology to investigate how Italian regional legislation disciplines the use of Strategic Environmental Assessment (SEA), the procedure used in the European Union (EU) to pursue sustainable development of policies, plans, and programs (PPPs). Our case study is the Italian regional level, examined to identify eventual flaws and areas for improvement for each regional legislative framework. For this purpose, this study refers to a selection of analytical criteria recurring in the international debate on sustainability assessments. Statistical multi-dimensional analysis is used to identify Italian regions with similar SEA legislation. We recognize four taxonomies, depending on the way regional legislation provides information about i) legislation and guidelines, ii) integration between SEA and PPPs, iii) sustainability goals, iv) technical organization, v) participatory organization, and vi) monitoring. The results suggest that Italian administrators should cooperate to improve legislation at the regional level. Acknowledging the institution-centred nature of SEA, this methodology could drive the EU to better support SEA development in countries with diversified traditions.

  14. Marijuana use among US tobacco users: Findings from wave 1 of the population assessment of tobacco health (PATH) study.

    Science.gov (United States)

    Strong, David R; Myers, Mark G; Pulvers, Kim; Noble, Madison; Brikmanis, Kristin; Doran, Neal

    2018-05-01

    With an increase in marijuana use among adults in the United States (US), understanding the potential impact of marijuana use on tobacco use and associated behavioral and health consequences, including respiratory conditions, is necessary. Survey responses from Wave 1 of the nationally representative Population Assessment of Tobacco and Health (PATH) Study were used to assess tobacco use and marijuana use among non-current tobacco users (n = 17,952) and current established tobacco-users classified as: cigarette only users (n = 8689), e-cigarette only users (n = 437), cigar only (traditional, cigarillo, or filtered) users (n = 706), hookah only users (n = 461), smokeless tobacco only users (n = 971), cigarette + e-cigarette users (n = 709), and users of multiple tobacco products (n = 2314). When compared to non-current tobacco users, each tobacco user group except smokeless only users had higher odds (odds ratios ranging from 3.86-8.07) of reporting current marijuana use. Among current tobacco users, higher levels of tobacco dependence did not explain the relationship between tobacco use and marijuana use. Additionally, concurrent marijuana use was associated with lower odds of attempts to quit tobacco (OR = 0.86, 95% CI = 0.79, 0.94, p users of tobacco and marijuana. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Ultrasonic Phased Array Assessment of the Interference Fit and Leak Path of the North Anna Unit 2 Control Rod Drive Mechanism Nozzle 63 with Destructive Validation

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Susan L.; Cinson, Anthony D.; MacFarlan, Paul J.; Hanson, Brady D.; Mathews, Royce

    2012-08-01

    The objective of this investigation was to evaluate the efficacy of ultrasonic testing (UT) for primary water leak path assessments of reactor pressure vessel (RPV) upper head penetrations. Operating reactors have experienced leakage when stress corrosion cracking of nickel-based alloy penetrations allowed primary water into the annulus of the interference fit between the penetration and the low-alloy steel RPV head. In this investigation, UT leak path data were acquired for an Alloy 600 control rod drive mechanism nozzle penetration, referred to as Nozzle 63, which was removed from the North Anna Unit 2 reactor when the RPV head was replaced in 2002. In-service inspection prior to the head replacement indicated that Nozzle 63 had a probable leakage path through the interference fit region. Nozzle 63 was examined using a phased-array UT probe with a 5.0-MHz, eight-element annular array. Immersion data were acquired from the nozzle inner diameter surface. The UT data were interpreted by comparing to responses measured on a mockup penetration with known features. Following acquisition of the UT data, Nozzle 63 was destructively examined to determine if the features identified in the UT examination, including leakage paths and crystalline boric acid deposits, could be visually confirmed. Additional measurements of boric acid deposit thickness and low-alloy steel wastage were made to assess how these factors affect the UT response. The implications of these findings for interpreting UT leak path data are described.

  16. The World Health Organization Performance Assessment Tool for Quality Improvement in Hospitals (PATH): an analysis of the pilot implementation in 37 hospitals

    NARCIS (Netherlands)

    Groene, Oliver; Klazinga, Niek; Kazandjian, Vahé; Lombrail, Pierre; Bartels, Paul

    2008-01-01

    OBJECTIVE: To evaluate the pilot implementation of the World Health Organization Performance Assessment Tool for Quality Improvement in hospitals (PATH). DESIGN: Semi-structured interviews with regional/country coordinators and Internet-based survey distributed to hospital coordinators. SETTING: A

  17. Path Dependence

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    Begrebet Path Dependence blev oprindelig udviklet inden for New Institutionel Economics af bl.a. David, Arthur og North. Begrebet har spredt sig vidt i samfundsvidenskaberne og undergået en udvikling. Dette paper propagerer for at der er sket så en så omfattende udvikling af begrebet, at man nu kan...... tale om 1. og 2. generation af Path Dependence begrebet. Den nyeste udvikling af begrebet har relevans for metodologi-diskusionerne i relation til Keynes...

  18. Assessments of proliferation capacity and viability of New Zealand rabbit peripheral blood endothelial progenitor cells labeled with superparamagnetic particles.

    Science.gov (United States)

    Mai, Xiao-Li; Ma, Zhan-Long; Sun, Jun-Hui; Ju, Sheng-Hong; Ma, Ming; Teng, Gao-Jun

    2009-01-01

    Magnetic resonance imaging (MRI) has proven to be effective in tracking the distribution of transplanted stem cells to target organs by way of labeling cells with superparamagnetic iron oxide particles (SPIO). However, the effect of SPIO upon labeled cells is still unclear on a cellular level. With this study, the proliferation and viability of New Zealand rabbit peripheral blood endothelial progenitor cells (EPCs) labeled with SPIO were evaluated and in vitro images were obtained using a 1.5 T MR scanner. Mononuclear cells (MNCs) were isolated from peripheral blood of the adult New Zealand rabbit and cultured in fibronectin-coated culture flasks, in which EPCs were identified from cell morphology, outgrowth characteristics, and internalization of DiI-Ac-LDL and binding to FITC-UEA I. EPCs were incubated with the self-synthesized poly-L-lysine-conjugated SPIO (PLL-SPIO) particles in a range of concentrations. The prevalence of iron-containing vesicles or endosomes in the cytoplasm of labeled cells was confirmed with Prussian blue staining and transmission electron microscopy. Tetrazolium salt (MTT) assay, cell apoptosis, and cycle detection were assessed to evaluate proliferation and function of various concentrations, magnetically labeled EPCs. The quantity of iron per cell was determined by atomic absorption spectrometry. The cells underwent MRI with different sequences. The result showed that rabbit EPCs were efficiently labeled with the home synthesized PLL-SPIO. There was found to be no statistically significant difference in the MTT values of light absorption measured on the third and fifth days. Between labeled and unlabeled cells, there were also no aberrations found in the cell cycles, apoptosis, or growth curves. The atomic absorption spectrophotometer showed that the intracellular content of Fe decreased as more time elapsed after labeling. The labeled EPCs demonstrated a loss of MRI signal intensity (SI) when compared with the SI of unlabeled cells

  19. Plutonium assessment modeling: government policy, non-proliferation, and the government fence

    International Nuclear Information System (INIS)

    Kurstedt, H.A. Jr.; Nachlas, J.A.

    1977-01-01

    Assessment modeling for the evaluation of plutonium as an energy resource is stressed, and generic mathematical model forms are outlined. Representative necessary objective functions are developed. Constraints and assumptions are listed. An example involving present-day light water reactor technology is demonstrated. Technical, environmental, and political implications are drawn. Specific new directions for analysis are suggested. The position of the boundary of government control and responsibility--the government exclusion fence--is shown to be a critical, but overlooked, constraint. Existing governmental uranium stockpiles may be an unmentioned, though important, constraint. Plutonium is the most abundant proven energy equivalent and most controversial energy resource. Plutonium results from an intermediate nuclear reactor processing stage starting with the raw material 238 U. Therefore, the plutonium resource differs from the 238 U resource only through minimal conversion losses and through the political and/or social will to perform the conversion. The relative abundance of 238 U, and therefore of plutonium is high. There is a great need to assess plutonium in relation to the potential available energy for a society in short supply

  20. Path Creation

    DEFF Research Database (Denmark)

    Karnøe, Peter; Garud, Raghu

    2012-01-01

    This paper employs path creation as a lens to follow the emergence of the Danish wind turbine cluster. Supplier competencies, regulations, user preferences and a market for wind power did not pre-exist; all had to emerge in a tranformative manner involving multiple actors and artefacts. Competenc......This paper employs path creation as a lens to follow the emergence of the Danish wind turbine cluster. Supplier competencies, regulations, user preferences and a market for wind power did not pre-exist; all had to emerge in a tranformative manner involving multiple actors and artefacts....... Competencies emerged through processes and mechanisms such as co-creation that implicated multiple learning processes. The process was not an orderly linear one as emergent contingencies influenced the learning processes. An implication is that public policy to catalyse clusters cannot be based...

  1. Can we predict nuclear proliferation

    International Nuclear Information System (INIS)

    Tertrais, Bruno

    2011-01-01

    The author aims at improving nuclear proliferation prediction capacities, i.e. the capacities to identify countries susceptible to acquire nuclear weapons, to interpret sensitive activities, and to assess nuclear program modalities. He first proposes a retrospective assessment of counter-proliferation actions since 1945. Then, based on academic studies, he analyzes what causes and motivates proliferation, with notably the possibility of existence of a chain phenomenon (mechanisms driving from one program to another). He makes recommendations for a global approach to proliferation prediction, and proposes proliferation indices and indicators

  2. Radiological criteria in assessing different types of proliferation in the mammary tissue with the help of microradiography

    International Nuclear Information System (INIS)

    Berger, M.S.

    1983-01-01

    26 tissue blocks of female patients with proliferating mastopathy were prepared as 2 mm-thick slices and a specimen radiogram was made of each. In all cases, the assessment of the histopathological examination lead to the result: benign. As complicated mastopathies must be regarded as risk factors with regard to later occurrence of a carcinoma, a microradiography of the sample tissue was made initially. This can help to show especially calcified micro spots in the tissue which might be an indication of malignant growth. Slices of 70 μm in thickness were taken pictures of in the microradiography chamber. The microcalcifications which could be recognized were compared to the results of the specimen radiography and the histological findings. In 15 cases, a far bigger number of micro-carlcifications (5 fold) could be established in the microradiogram; there were no such significant differences in the presentation of the calcifications in the other cases. As the tissue slice in specimen radiography is 2.5 times as thick, also the quantity of calcification must be correspondingly more. As, however, in 15 cases microradiography showed even more calcification than in the specimen radiogram, this proves the efficiency of microradiography for imaging microcalcifications. (orig./MG) [de

  3. 77 FR 48994 - Submission for OMB Review; Comment Request; Population Assessment of Tobacco and Health (PATH) Study

    Science.gov (United States)

    2012-08-15

    ... Institutes of Health (NIH) National Institute on Drug Abuse (NIDA) and in partnership with the Food and Drug... adults, the PATH study is designed to establish a population-based framework for monitoring and... the Family Smoking Prevention and Tobacco Control Act (FSPTCA) to regulate tobacco-product advertising...

  4. Assessing Receiving Water Quality Impacts due to Flow Path Alteration in Residential Catchments, using the Stormwater and Wastewater Management Model

    Science.gov (United States)

    Wolosoff, S. E.; Duncan, J.; Endreny, T.

    2001-05-01

    The Croton water supply system, responsible for supplying approximately 10% of New York City's water, provides an opportunity for exploration into the impacts of significant terrestrial flow path alteration upon receiving water quality. Natural flow paths are altered during residential development in order to allow for construction at a given location, reductions in water table elevation in low lying areas and to provide drainage of increased overland flow volumes. Runoff conducted through an artificial drainage system, is prevented from being attenuated by the natural environment, thus the pollutant removal capacity inherent in most natural catchments is often limited to areas where flow paths are not altered by development. By contrasting the impacts of flow path alterations in two small catchments in the Croton system, with different densities of residential development, we can begin to identify appropriate limits to the re-routing of runoff in catchments draining into surface water supplies. The Stormwater and Wastewater Management Model (SWMM) will be used as a tool to predict the runoff quantity and quality generated from two small residential catchments and to simulate the potential benefits of changes to the existing drainage system design, which may improve water quality due to longer residence times.

  5. Your choice MATor(s) : large-scale quantitative anonymity assessment of Tor path selection algorithms against structural attacks

    OpenAIRE

    Backes, Michael; Meiser, Sebastian; Slowik, Marcin

    2015-01-01

    In this paper, we present a rigorous methodology for quantifying the anonymity provided by Tor against a variety of structural attacks, i.e., adversaries that compromise Tor nodes and thereby perform eavesdropping attacks to deanonymize Tor users. First, we provide an algorithmic approach for computing the anonymity impact of such structural attacks against Tor. The algorithm is parametric in the considered path selection algorithm and is, hence, capable of reasoning about variants of Tor and...

  6. Waste management and proliferation: an assessment of technologies and policies relevant to nuclear power. Final report, June 1975--March 1977

    International Nuclear Information System (INIS)

    Goldstein, M.K.; Anderson, R.N.; Selvaduray, G.; Gangwer, T.; Braun, C.; Goellner, D.; Malone, R.; Sevian, W.A.; Lester, R.

    1977-01-01

    Some of the long-term hazards from radioactive waste management and the problems in safeguarding plutonium in a world moving toward a plutonium economy are presented. To ameliorate these problems, several alternative fuel cycle options are presented: homogeneous reactor, denatured thorium, open, tandem, accelerator-regenerative, co-processing, plutonium, spiking, and partitioning. An assessment is made of a variety of separation technologies applied to these options, including a review of 32 different reprocessing methods. The effects of these options on both U.S. and transnational policies regarding waste management and proliferation are examined. This study addresses the transnational environmental policy issues created by a worldwide nuclear industry and suggests the need for two international organizations: one to manage spent fuel and the breeder fuel cycle; the second to protect the global environment. Two photochemical schemes for improving existing reprocessing technology by reducing wastes and materials unaccounted for (MUF) are presented. The applicability of this technology, along with column chromatography, Talspeak, and other separation methods, is examined relative to various waste management alternatives including the partitioning and transmutation option. A computer model to determine the effectiveness of transmutation as a function of separation efficiency has been developed and employed. To estimate health impacts from various fuel cycle options, the Brookhaven energy system network simulator has been integrated with an atmospheric dispersion and pathway analysis model. Using revised 222 Rn emission data, it is estimated from the linear hypothesis that the number of excess cancers is slightly less for the open than for the closed cycle. More importantly, the number of excess cancers induced by mill and mine tailings is from one to two times that caused by the rest of the entire fuel cycle

  7. Path tortuosity in everyday movements of elderly persons increases fall prediction beyond knowledge of fall history, medication use, and standardized gait and balance assessments.

    Science.gov (United States)

    Kearns, William D; Fozard, James L; Becker, Marion; Jasiewicz, Jan M; Craighead, Jeffrey D; Holtsclaw, Lori; Dion, Charles

    2012-09-01

    We hypothesized that variability in voluntary movement paths of assisted living facility (ALF) residents would be greater in the week preceding a fall compared with residents who did not fall. Prospective, observational study using telesurveillance technology. Two ALFs. The sample consisted of 69 older ALF residents (53 female) aged 76.9 (SD ± 11.9 years). Daytime movement in ALF common use areas was automatically tracked using a commercially available ultra-wideband radio real-time location sensor network with a spatial resolution of approximately 20 cm. Movement path variability (tortuosity) was gauged using fractal dimension (fractal D). A logistic regression was performed predicting movement related falls from fractal D, presence of a fall in the prior year, psychoactive medication use, and movement path length. Fallers and non-fallers were also compared on activities of daily living requiring supervision or assistance, performance on standardized static and dynamic balance, and stride velocity assessments gathered at the start of a 1-year fall observation period. Fall risk due to cognitive deficit was assessed by the Mini Mental Status Examination (MMSE), and by clinical dementia diagnoses from participant's activities of daily living health record. Logistic regression analysis revealed odds of falling increased 2.548 (P = .021) for every 0.1 increase in fractal D, and having a fall in the prior year increased odds of falling by 7.36 (P = .006). There was a trend for longer movement paths to reduce the odds of falling (OR .976 P = .08) but it was not significant. Number of psychoactive medications did not contribute significantly to fall prediction in the model. Fallers had more variable stride-to-stride velocities and required more activities of daily living assistance. High fractal D levels can be detected using commercially available telesurveillance technologies and offers a new tool for health services administrators seeking to reduce falls at their

  8. Proliferation risks

    International Nuclear Information System (INIS)

    Carchon, R.

    1998-09-01

    The report gives an overview of different aspects related to safeguards of fissile materials. Existing treaties including the Non-Proliferation Treaty, and the Tlatelolco and the Rarotonga Treaties are discussed. An overview of safeguards systems for the control of fissile materials as well as the role of various authorities is given. An overall overview of proliferation risks, the physical protection of fissile materials and the trade in fissile materials is given. Finally, the status in problem countries and de facto nuclear weapon states is discussed

  9. Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation

    Energy Technology Data Exchange (ETDEWEB)

    Lecomte, Sylvain; Lelong, Marie; Bourgine, Gaëlle [Institut de Recherche en Santé-Environnement-Travail (IRSET), Inserm UMR 1085, Team Transcription, Environment and Cancer, University of Rennes 1, 9 Avenue du Pr Léon Bernard, 35000 Rennes (France); Efstathiou, Theo [Laboratoire Nutrinov, Technopole Atalante Champeaux, 8 rue Jules Maillard de la Gournerie, 35012 Rennes Cedex (France); Saligaut, Christian [Institut de Recherche en Santé-Environnement-Travail (IRSET), Inserm UMR 1085, Team Transcription, Environment and Cancer, University of Rennes 1, 9 Avenue du Pr Léon Bernard, 35000 Rennes (France); Pakdel, Farzad, E-mail: farzad.pakdel@univ-rennes1.fr [Institut de Recherche en Santé-Environnement-Travail (IRSET), Inserm UMR 1085, Team Transcription, Environment and Cancer, University of Rennes 1, 9 Avenue du Pr Léon Bernard, 35000 Rennes (France)

    2017-06-15

    Estrogen receptors (ERs) α and β are distributed in most tissues of women and men. ERs are bound by estradiol (E2), a natural hormone, and mediate the pleiotropic and tissue-specific effects of E2, such as proliferation of breast epithelial cells or protection and differentiation of neuronal cells. Numerous environmental molecules, called endocrine disrupting compounds, also interact with ERs. Phytoestrogens belong to this large family and are considered potent therapeutic molecules that act through their selective estrogen receptor modulator (SERM) activity. Using breast cancer cell lines as a model of estrogen-dependent proliferation and a stably ER-expressing PC12 cell line as a model of neuronal differentiating cells, we studied the SERM activity of major dietary compounds, such as apigenin, liquiritigenin, daidzein, genistein, coumestrol, resveratrol and zearalenone. The ability of these compounds to induce ER-transactivation and breast cancer cell proliferation and enhance Nerve Growth Factor (NGF) -induced neuritogenesis was assessed. Surprisingly, although all compounds were able to activate the ER through an estrogen responsive element reporter gene, they showed differential activity toward proliferation or differentiation. Apigenin and resveratrol showed a partial or no proliferative effect on breast cancer cells but fully contributed to the neuritogenesis effect of NGF. However, daidzein and zearalenone showed full effects on cellular proliferation but did not induce cellular differentiation. In summary, our results suggest that the therapeutic potential of phytoestrogens can diverge depending on the molecule and the phenotype considered. Hence, apigenin and resveratrol might be used in the development of therapeutics for breast cancer and brain diseases. - Highlights: • SERM activity of dietary compounds on proliferation and differentiation is studied. • All the dietary compounds tested transactivate estrogen receptors. • Apigenin and

  10. Using client-side event logging and path tracing to assess and improve the quality of web-based surveys.

    Science.gov (United States)

    White, Thomas M; Hauan, Michael J

    2002-01-01

    Web-based data collection has considerable appeal. However, the quality of data collected using such instruments is often questionable. There can be systematic problems with the wording of the surveys, and/or the means with which they are deployed. In unsupervised data collection, there are also concerns about whether subjects understand the questions, and wehther they are answering honestly. This paper presents a schema for using client-side timestamps and traces of subjects' paths through instruments to detect problems with the definition of instruments and their deployment. We discuss two large, anonymous, web-based, medical surveys as examples of the utility of this approach.

  11. Machine Learning Based Dimensionality Reduction Facilitates Ligand Diffusion Paths Assessment: A Case of Cytochrome P450cam.

    Science.gov (United States)

    Rydzewski, J; Nowak, W

    2016-04-12

    In this work we propose an application of a nonlinear dimensionality reduction method to represent the high-dimensional configuration space of the ligand-protein dissociation process in a manner facilitating interpretation. Rugged ligand expulsion paths are mapped into 2-dimensional space. The mapping retains the main structural changes occurring during the dissociation. The topological similarity of the reduced paths may be easily studied using the Fréchet distances, and we show that this measure facilitates machine learning classification of the diffusion pathways. Further, low-dimensional configuration space allows for identification of residues active in transport during the ligand diffusion from a protein. The utility of this approach is illustrated by examination of the configuration space of cytochrome P450cam involved in expulsing camphor by means of enhanced all-atom molecular dynamics simulations. The expulsion trajectories are sampled and constructed on-the-fly during molecular dynamics simulations using the recently developed memetic algorithms [ Rydzewski, J.; Nowak, W. J. Chem. Phys. 2015 , 143 ( 12 ), 124101 ]. We show that the memetic algorithms are effective for enforcing the ligand diffusion and cavity exploration in the P450cam-camphor complex. Furthermore, we demonstrate that machine learning techniques are helpful in inspecting ligand diffusion landscapes and provide useful tools to examine structural changes accompanying rare events.

  12. Assessment of 16 chemicals on proliferation and apoptosis in human neuroprogenitor cells using high-content image analysis (HCA).

    Science.gov (United States)

    The need for efficient methods of screening chemicals for the potential to cause developmental neurotoxicity is paramount. We previously described optimization of an HCA assay for proliferation and apoptosis in ReNcell CX cells (ReN), identifying appropriate controls. Utility of ...

  13. Nuclear proliferation

    International Nuclear Information System (INIS)

    Stencel, S.

    1978-01-01

    The terms and reactions to President Carter's nuclear policy, culminating in the 1978 Nuclear Non-Proliferation Act, are reviewed and analyzed. The new law increases restrictions on nuclear exports, encourages continued use of light water reactors in preference to plutonium-fueled reactors, and emphasizes technical solutions to proliferation problems. Critics of the law point out that it will hurt U.S. trade unfairly, that other countries do not have as many fuel options as the U.S. has, and that nuclear sales have as many political and economic as technical solutions. Compromise areas include new international safety guidelines, the possibility of an international nuclear fuel bank, and a willingness to consider each case on its merits. 21 references

  14. Assessment of helium effects on swelling by reirradiation in FFTF of Path A alloys previously irradiated in HFIR

    International Nuclear Information System (INIS)

    Maziasz, P.J.; Garner, F.A.; Brager, H.R.

    1985-01-01

    Specimens of the Path A Prime Candidate Alloys and of N-lot SS 316 were irradiated in HFIR at 400 to 600 0 C to fluences producing approximately 10 to 44 dpa and 500 to 3600 at. ppm He, in both the solution annealed and 20 to 25% cold-worked conditions. The cavity swelling and total microstructural evolution of most samples were observed via transmission electron microscopy on identical disks irradiated side by side in HFIR, and immersion densities were also measured prior to insertion into FFTF/MOTA (Materials Open Test Assembly of the Fast Flux Test Facility). These disks are being irradiated in the FFTF/MOTA (cycles 5 and 6), side by side with disks of the same materials which were not previously irradiated in HFIR. These specimens have been divided into two subsets for discharges after 30 and 60 dpa. 4 references, 1 table

  15. Using stable isotope tracers to assess hydrological flow paths, residence times and landscape influences in a nested mesoscale catchment

    Directory of Open Access Journals (Sweden)

    P. Rodgers

    2005-01-01

    Full Text Available δ18O measurements in precipitation and stream waters were used to investigate hydrological flow paths and residence times at nested spatial scales in the mesoscale (233 km2 River Feugh catchment in the northeast of Scotland over the 2001-2002 hydrological year. Precipitation δ18O exhibited strong seasonal variation, which although significantly damped within the catchment, was reflected in stream water at six sampling sites. This allowed δ18O variations to be used to infer the relative influence of soil-derived storm flows with a seasonally variable isotopic signature, and groundwater of apparently more constant isotopic composition. Periodic regression analysis was then used to examine the sub-catchment difference using an exponential flow model to provide indicative estimates of mean stream water residence times, which varied between approximately 3 and 14 months. This showed that the effects of increasing scale on estimated mean stream water residence time was minimal beyond that of the smallest (ca. 1 km2 headwater catchment scale. Instead, the interaction of catchment soil cover and topography appeared to be the dominant controlling influence. Where sub-catchments had extensive peat coverage, responsive hydrological pathways produced seasonally variable δ18O signatures in runoff with short mean residence times (ca. 3 months. In contrast, areas dominated by steeper slopes, more freely draining soils and larger groundwater storage in shallow valley-bottom aquifers, deeper flow paths allow for more effective mixing and damping of δ18O indicating longer residence times (>12 months. These insights from δ18O measurements extend the hydrological understanding of the Feugh catchment gained from previous geochemical tracer studies, and demonstrate the utility of isotope tracers in investigating the interaction of hydrological processes and catchment characteristics at larger spatial scales.

  16. Assessment of direct analgesic effect of duloxetine for chronic low back pain: post hoc path analysis of double-blind, placebo-controlled studies

    Directory of Open Access Journals (Sweden)

    Enomoto H

    2017-06-01

    Full Text Available Hiroyuki Enomoto,1 Shinji Fujikoshi,2 Jumpei Funai,3 Nao Sasaki,4 Michael H Ossipov,5 Toshinaga Tsuji,6 Levent Alev,7 Takahiro Ushida8 1Medical Science, Eli Lilly Japan K.K., Tokyo, 2Statistical Science, 3Science Communications, 4Medical Science, Eli Lilly Japan K.K., Kobe, Japan; 5Clinical Division, inVentiv Health, LLC, Blue Bell, PA, USA; 6Medical Affairs Department, Shionogi & Co., Ltd., Osaka, Japan; 7Medical Department, Lilly Turkey, Istanbul, Turkey; 8Multidisciplinary Pain Center, Aichi Medical University, Nagakute, Aichi, Japan Background: Comorbid depression and depressive symptoms are common in patients with chronic low back pain (CLBP. Duloxetine is clinically effective in major depressive disorder and several chronic pain states, including CLBP. The objective of this post hoc meta-analysis was to assess direct and indirect analgesic efficacy of duloxetine for patients with CLBP in previous clinical trials. Methods: Post hoc path analyses were conducted of 3 randomized, double-blind, clinical studies of patients receiving duloxetine or placebo for CLBP. The primary outcome measure for pain was the Brief Pain Inventory, average pain score. A secondary outcome measure, the Beck Depression Inventory-II, was used for depressive symptoms. The changes in score from baseline to endpoint were determined for each index. Path analyses were employed to calculate the proportion of analgesia that may be attributed to a direct effect of duloxetine on pain.Results: A total of 851 patients (400 duloxetine and 451 placebo were included in this analysis. Duloxetine significantly improved pain scores compared with placebo (p<0.001. It also significantly improved depressive scores compared with placebo (p=0.015. Path analyses showed that 91.1% of the analgesic effect of duloxetine could be attributed to a direct analgesic effect, and 8.9% to its antidepressant effect. Similar results were obtained when data were evaluated at weeks 4 and 7, and when

  17. Assessment and reduction of proliferation risk of reactor-grade plutonium regarding construction of ‘fizzle bombs’ by terrorists

    International Nuclear Information System (INIS)

    Serfontein, Dawid E.; Mulder, Eben J.; Reitsma, Frederik

    2014-01-01

    The approximately 23.7 wt% 240 Pu in reactor-grade plutonium denatures the 239 Pu to the extent that it cannot fuel high yield nuclear weapons. 240 Pu has a high spontaneous fission rate, which increases the spontaneous neutron flux within the fuel. When such a nuclear weapon is triggered, these neutrons cause the nuclear fission chain reaction to pre-detonate which blows the imploding fuel shell apart before the designed level of compression and reactivity could be attained, thereby greatly reducing the average energy yield of such “fizzle” bombs. Therefore reactor-grade plutonium is normally viewed as highly proliferation resistant. In this article the literature on the proliferation resistance of reactor-grade plutonium and on the mechanism and effect of fizzle bombs is reviewed in order to test this view. It is shown that even very low yield fizzle bombs, exploded in urban areas, would still cause serious blast damage as well as radioactive contamination. Combined with the high levels of induced terror, fizzle bombs might thus be attractive psychological weapons for terrorists. Therefore reactor-grade plutonium may not be sufficiently proliferation resistant against nuclear terrorism. However, denaturisation with more than 9% 238 Pu produces high levels of decay heat which will melt or explode the high explosives around uncooled implosion type weapons, rendering them useless. Unfortunately, reactor-grade Pu contains only 2.7% 238 Pu and is thus not sufficiently proliferation resistant in this respect. It is also shown that the associated neptunium poses a substantial proliferation risk. In the present study strong improvement of the proliferation resistance was demonstrated by simulation of incineration of reactor-grade plutonium in the 400 MW th Pebble Bed Modular Reactor Demonstration Power Plant. Results for modified fuel cycles, aimed at transmutating 237 Np to 238 Pu are also reported. However, these modifications increased the disloaded heavy metal

  18. Assessment and reduction of proliferation risk of reactor-grade plutonium regarding construction of ‘fizzle bombs’ by terrorists

    Energy Technology Data Exchange (ETDEWEB)

    Serfontein, Dawid E., E-mail: Dawid.Serfontein@nwu.ac.za [School for Mechanical and Nuclear Engineering, North West University (PUK-Campus), PRIVATE BAG X6001 (Internal Post Box 360), Potchefstroom 2520 (South Africa); Mulder, Eben J. [School for Mechanical and Nuclear Engineering, North West University (South Africa); Reitsma, Frederik [Calvera Consultants (South Africa)

    2014-05-01

    The approximately 23.7 wt% {sup 240}Pu in reactor-grade plutonium denatures the {sup 239}Pu to the extent that it cannot fuel high yield nuclear weapons. {sup 240}Pu has a high spontaneous fission rate, which increases the spontaneous neutron flux within the fuel. When such a nuclear weapon is triggered, these neutrons cause the nuclear fission chain reaction to pre-detonate which blows the imploding fuel shell apart before the designed level of compression and reactivity could be attained, thereby greatly reducing the average energy yield of such “fizzle” bombs. Therefore reactor-grade plutonium is normally viewed as highly proliferation resistant. In this article the literature on the proliferation resistance of reactor-grade plutonium and on the mechanism and effect of fizzle bombs is reviewed in order to test this view. It is shown that even very low yield fizzle bombs, exploded in urban areas, would still cause serious blast damage as well as radioactive contamination. Combined with the high levels of induced terror, fizzle bombs might thus be attractive psychological weapons for terrorists. Therefore reactor-grade plutonium may not be sufficiently proliferation resistant against nuclear terrorism. However, denaturisation with more than 9% {sup 238}Pu produces high levels of decay heat which will melt or explode the high explosives around uncooled implosion type weapons, rendering them useless. Unfortunately, reactor-grade Pu contains only 2.7% {sup 238}Pu and is thus not sufficiently proliferation resistant in this respect. It is also shown that the associated neptunium poses a substantial proliferation risk. In the present study strong improvement of the proliferation resistance was demonstrated by simulation of incineration of reactor-grade plutonium in the 400 MW{sub th} Pebble Bed Modular Reactor Demonstration Power Plant. Results for modified fuel cycles, aimed at transmutating {sup 237}Np to {sup 238}Pu are also reported. However, these

  19. Safety assessment for a potential SNF repository and its implication to the proliferation resistance nuclear fuel cycle

    International Nuclear Information System (INIS)

    Hwang, Y.; Jeong, M.S.; Seo, C.S.

    2007-01-01

    KAERI is developing the pyro-process technology to minimize the burden on permanent disposal of spent nuclear fuel. In addition, KAERI has developed the Korean Reference System for potential spent nuclear fuel disposal since 1997. The deep geologic disposal system is composed of a multi-barrier system in a crystalline rock to dispose of 36,000 MT of spent nuclear fuel (SNF) from a CANDU and a PWR. Quite recently, introduction of advanced nuclear fuel cycles such as pyro-processing is a big issue to solve the everlasting disposal problem and to assure the sustainable supply of fuel for reactors. To compare the effect of direct disposal of SNF with that of the high level waste disposal for waste generated from the advanced nuclear fuel cycles, the total system performance assessment for two different schemes is developed; one for direct disposal of SNF and the other for the introduction of the pyro-processing and direct disposal CANDU spent nuclear fuel. The safety indicators to assess the environmental friendliness of the disposal option are annual individual doses, toxicities and risks. Even though many scientists use the toxicity to understand the environmental friendliness of the disposal, scientifically the annual individual doses or risks are meaningful indicators for it. The major mechanisms to determine the doses and risks for direct disposal are as follows: (1) Dissolution mechanisms of uranium dioxides which control the dissolution of most nuclides such as TRU's and most parts of fission products. (2) Instant release fraction of highly soluble nuclides such as I-129, C-135, Tc-99, and others. (3) Retardation and dilution effect of natural and engineered barriers. (4) Dilution effect in the biosphere. The dominant nuclide is I-129 which follows both congruent and instantaneous release modes. Since its long half life associated with the instantaneous release I-129 is dominant well beyond one million. The impact of the TRU's is negligible until the significant

  20. Proliferation resistance modeling

    International Nuclear Information System (INIS)

    Bari, R.; Peterson, P.; Roglans, J.; Mladineo, S.; Nuclear Engineering Division; BNL; Univ. of California at Berkely; PNNL

    2004-01-01

    The National Nuclear Security Administration is developing methods for nonproliferation assessments. A working group on Nonproliferation Assessment Methodology (NPAM) assembled a toolbox of methods for various applications in the nonproliferation arena. One application of this methodology is to the evaluation of the proliferation resistance of Generation IV nuclear energy systems. This paper first summarizes the key results of the NPAM program and then provides results obtained thus far in the ongoing application, which is co-sponsored by the DOE Office of Nuclear Energy Science and Technology. In NPAM, a top-level measure of proliferation resistance for a fuel cycle system is developed from a hierarchy of metrics. The problem is decomposed into: metrics to be computed, barriers to proliferation, and a finite set of threats. The analyst models the process undertaken by the proliferant to overcome barriers to proliferation and evaluates the outcomes. In addition to proliferation resistance (PR) evaluation, the application also addresses physical protection (PP) evaluation against sabotage and theft. The Generation IV goal for future nuclear energy systems is to assure that they are very unattractive and the least desirable route for diversion or theft of weapons-usable materials, and provide increased physical protection against terrorism. An Expert Group, addressing this application, has identified six high-level measures for the PR goals (six measures have also been identified for the PP goals). Combined together, the complete set of measures provides information for program policy makers and system designers to compare specific system design features and integral system characteristics and to make choices among alternative options. The Group has developed a framework for a phased evaluation approach to analyzing PR and PP of system characteristics and to quantifying metrics and measures. This approach allows evaluations to become more detailed and representative

  1. Path Creation, Path Dependence and Breaking Away from the Path

    OpenAIRE

    Wang, Jens; Hedman, Jonas; Tuunainen, Virpi Kristiina

    2016-01-01

    The explanation of how and why firms succeed or fail is a recurrent research challenge. This is particularly important in the context of technological innovations. We focus on the role of historical events and decisions in explaining such success and failure. Using a case study of Nokia, we develop and extend a multi-layer path dependence framework. We identify four layers of path dependence: technical, strategic and leadership, organizational, and external collaboration. We show how path dep...

  2. An Introduction to The Interdisciplinary Concept of Risk-Informed Proliferation Resistance

    International Nuclear Information System (INIS)

    Gouveia, Fernando

    2010-01-01

    The nonproliferation community is rich in diverse attempts aimed at predicting and preventing attempts at nuclear proliferation. Such efforts, however, are rarely incorporated into a holistic approach well-suited to solving both existing and emerging proliferation dilemmas. This division is particularly apparent with respect to the partition that separates the socio-political and technical approaches to solving such problems, approaches which are very often developed and utilized in isolation. Complicating matters further, are the diverse positions taken by various entities as they relate to the secure implementation of nuclear energy world-wide. Such positions range from the obdurate belief in the supposed inherent proliferation resistance of traditional spent fuel, to those regarding all nuclear energy systems as inherently proliferation prone, given their core reliance on the sensitive technologies of enrichment and reprocessing. Accordingly, moderates have argued for a risk-informed approach to combat nuclear proliferation, combining institutional factors, such as IAEA safeguards, with innovative reactor and fuel designs to bring about an acceptable notion of proliferation resistance. To this end, methodologies have been developed, which seek to assess and score attained proliferation resistance. Most notably, these include, the Proliferation Resistance and Physical Protection (PR and PP) methodology prepared by the GEN-IV International Forum and the IAEA's International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). Such approaches have greatly advanced the concept of proliferation resistance; however, they remain limited by their exclusive concentration on the technological determinants of proliferation and non-consideration of other, equally important, socio-political determinants. This limitation is significant as numerous incidents have illustrated the ability of atypical states to find alternate paths to proliferation, for example

  3. Statistical multi-path exposure method for assessing the whole-body SAR in a heterogeneous human body model in a realistic environment.

    Science.gov (United States)

    Vermeeren, Günter; Joseph, Wout; Martens, Luc

    2013-04-01

    Assessing the whole-body absorption in a human in a realistic environment requires a statistical approach covering all possible exposure situations. This article describes the development of a statistical multi-path exposure method for heterogeneous realistic human body models. The method is applied for the 6-year-old Virtual Family boy (VFB) exposed to the GSM downlink at 950 MHz. It is shown that the whole-body SAR does not differ significantly over the different environments at an operating frequency of 950 MHz. Furthermore, the whole-body SAR in the VFB for multi-path exposure exceeds the whole-body SAR for worst-case single-incident plane wave exposure by 3.6%. Moreover, the ICNIRP reference levels are not conservative with the basic restrictions in 0.3% of the exposure samples for the VFB at the GSM downlink of 950 MHz. The homogeneous spheroid with the dielectric properties of the head suggested by the IEC underestimates the absorption compared to realistic human body models. Moreover, the variation in the whole-body SAR for realistic human body models is larger than for homogeneous spheroid models. This is mainly due to the heterogeneity of the tissues and the irregular shape of the realistic human body model compared to homogeneous spheroid human body models. Copyright © 2012 Wiley Periodicals, Inc.

  4. Preventing proliferation

    International Nuclear Information System (INIS)

    Rathjens, G.

    1983-01-01

    Challenging the argument that nuclear proliferation may be stabilizing, the author cites the Israeli attack on Iraq as evidence that emergent nuclear states may be moved to attack their adversaries.The larger the number of decision makers who can unleash nuclear weapons, the greater the liklihood of their use. Several reasons are cited for nations to seek nuclear capability: the accelerated spread of technology, the deterioration in US-Soviet relations and strength relative to their nations, the high cost of conventional weapons, and a loss of confidence in the international safeguards system. The imposition of constraints, such as a Comprehensive Test Ban Treaty, on nuclear trade and technology transfer are likely to have a high cost. The US position on this issue is likely to be determined by the balance of power with the Soviet Union. 5 references

  5. PATHS groundwater hydrologic model

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, R.W.; Schur, J.A.

    1980-04-01

    A preliminary evaluation capability for two-dimensional groundwater pollution problems was developed as part of the Transport Modeling Task for the Waste Isolation Safety Assessment Program (WISAP). Our approach was to use the data limitations as a guide in setting the level of modeling detail. PATHS Groundwater Hydrologic Model is the first level (simplest) idealized hybrid analytical/numerical model for two-dimensional, saturated groundwater flow and single component transport; homogeneous geology. This document consists of the description of the PATHS groundwater hydrologic model. The preliminary evaluation capability prepared for WISAP, including the enhancements that were made because of the authors' experience using the earlier capability is described. Appendixes A through D supplement the report as follows: complete derivations of the background equations are provided in Appendix A. Appendix B is a comprehensive set of instructions for users of PATHS. It is written for users who have little or no experience with computers. Appendix C is for the programmer. It contains information on how input parameters are passed between programs in the system. It also contains program listings and test case listing. Appendix D is a definition of terms.

  6. Indicators of dependence for different types of tobacco product users: Descriptive findings from Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) study.

    Science.gov (United States)

    Strong, David R; Pearson, Jennifer; Ehlke, Sarah; Kirchner, Thomas; Abrams, David; Taylor, Kristie; Compton, Wilson M; Conway, Kevin P; Lambert, Elizabeth; Green, Victoria R; Hull, Lynn C; Evans, Sarah E; Cummings, K Michael; Goniewicz, Maciej; Hyland, Andrew; Niaura, Raymond

    2017-09-01

    With no established standard for assessing tobacco dependence (TD) across tobacco products in surveys, the Population Assessment of Tobacco and Health (PATH) Study provides a unique platform for examining the psychometric properties and validity of multiple indicators of tobacco dependence across a range of tobacco products. A U.S. nationally representative sample from the 32,320 adult Wave 1 interviews with analyses focused on 14,287 respondents who were current established users of tobacco products. This analysis confirms a single primary latent construct underlying responses to TD indicators for cigarettes, e-cigarettes, cigars, hookah, and smokeless tobacco products. Mutually exclusive past year tobacco-user groups included: cigarette only (n=8689), e-cigarette only (n=437), cigar only (traditional, cigarillo, or filtered) (n=706), hookah only (n=461), smokeless tobacco only (n=971), cigarette plus e-cigarette (n=709), and multiple tobacco product users (n=2314). Differential Item Functioning (DIF) analyses supported use of 16 of the 24 examined TD indicators for comparisons across tobacco users. With cigarette users as a reference (mean=0.0, SD=1.0), we observed a range of TD with hookah (mean=-1.71) and cigar (mean=-1.92) only users being the lowest, and cigarette plus e-cigarette product users being the highest (mean=0.35). Regression models including sociodemographic factors supported concurrent validity with increased product use frequency and TD among cigarette-only (p<0.001), e-cigarette only (p<0.002), cigar (p<0.001), hookah only (p<0.001), and smokeless tobacco users (p<0.001). The PATH Study Adult Wave 1 Questionnaire provided psychometrically valid measures of TD that enables future regulatory investigations of nicotine dependence across tobacco products. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. The value of ultrasound contrast for assessing cancer cell proliferation and invasion function as well as angiogenesis in lesions of in patients with gastric cancer

    Directory of Open Access Journals (Sweden)

    Qin Yang

    2017-06-01

    Full Text Available Objective: To study the value of ultrasound contrast for assessing cancer cell proliferation and invasion as well as angiogenesis in lesions of in patients with gastric cancer. Methods: A total of 39 patients with gastric cancer and 48 patients with gastric ulcer who were treated in our hospital between August 2012 and May 2016 were included in gastric cancer group and gastric ulcer group respectively, and 50 healthy subjects who accepted gastroscopy in our hospital during the same period were included in normal control group. The day after admission, color Doppler diasonograph was used to test the gastric ultrasound contrast parameters; fluorescence quantitative PCR method was used to detect the proliferation and invasion gene mRNA expression in stomach tissue; enzyme-linked immunosorbent assay (ELISA was used to detect the serum angiogenesis index levels. Results: Ultrasound contrast parameters ET and TTP levels of gastric cancer group and gastric ulcer group were significantly lower than those of normal control group, and ultrasound contrast parameters ET and TTP levels of gastric cancer group were significantly lower than those of gastric ulcer group; Stat3, Survivin, Bcl-2, 毬-catenin, eIF4E, CD44, UHRF1 and c-met mRNA expression in tissue as well as VEGF, EGFR, HIF-毩 and Ang-2 levels in serum of gastric cancer group were higher than those of gastric ulcer group and normal control group while E-cadherin mRNA expression in tissue was lower than those of gastric ulcer group and normal control group; Spearman correlation analysis showed that ultrasound contrast parameters ET and TTP levels were correlated with the cancer cell proliferation and invasion function as well as angiogenesis indexes in lesions. Conclusion: Ultrasound contrast parameters can accurately assess the malignant degree of gastric cancer, and is expected to become the reliable means for early diagnosis and treatment guidance of gastric cancer in the future.

  8. Feynman's path integrals and Bohm's particle paths

    International Nuclear Information System (INIS)

    Tumulka, Roderich

    2005-01-01

    Both Bohmian mechanics, a version of quantum mechanics with trajectories, and Feynman's path integral formalism have something to do with particle paths in space and time. The question thus arises how the two ideas relate to each other. In short, the answer is, path integrals provide a re-formulation of Schroedinger's equation, which is half of the defining equations of Bohmian mechanics. I try to give a clear and concise description of the various aspects of the situation. (letters and comments)

  9. Path coupling and aggregate path coupling

    CERN Document Server

    Kovchegov, Yevgeniy

    2018-01-01

    This book describes and characterizes an extension to the classical path coupling method applied to statistical mechanical models, referred to as aggregate path coupling. In conjunction with large deviations estimates, the aggregate path coupling method is used to prove rapid mixing of Glauber dynamics for a large class of statistical mechanical models, including models that exhibit discontinuous phase transitions which have traditionally been more difficult to analyze rigorously. The book shows how the parameter regions for rapid mixing for several classes of statistical mechanical models are derived using the aggregate path coupling method.

  10. Current limitations and a path forward to improve testing for the environmental assessment of endocrine active substances

    DEFF Research Database (Denmark)

    Coady, Katherine K.; Biever, Ronald C.; Denslow, Nancy D.

    , statistical power to detect biologically significant adverse effects, delivery and analytical measurement of test substances, availability of technical expertise, and study interpretation, including linking mechanistic and apical effects. Some of these areas can be addressed by the lessons learned and best...... issue of significant concern to for current EACS screening/testing programs involves resources in regard such as to cost, time, trained personnel, and animal use. This is especially problematic when considering the number of chemicals that some regulatory authorities need to assess. One way to address...... practices developed through recent experiences conducting EAC screening/testing. Additionally, the collective assessment of EAC screening and testing data (e.g. compilation of historical control data) can be leveraged to refine test designs and performance criteria to maximize the power and utility of EAC...

  11. Source and path parameters determination based on data from the digital accelerometer and CALIXTO networks to assess the seismic hazard

    International Nuclear Information System (INIS)

    Radulian, M.; Anghel, M.; Ardeleanu, L.; Bazacliu, O.; Grecu, B.; Popa, M.; Popescu, E.; Rizescu, M.

    2002-01-01

    For any strategy of seismic risk mitigation, it is essential to have a realistic description of the seismic input that means of the source and structure parameters. The present project is focused on the problem of determining accurate source and structure parameters and to analyze the way these parameters influence the seismic hazard distribution. The main objectives of the project are: determination of seismic source parameters, scaling properties, database of recent earthquakes, seismic source effects on the seismic hazard distribution, seismic attenuation, site effects, realistic scenarios for Vrancea earthquakes. To this purpose, we valorize the data provided by the instruments installed recently on the Romanian territory, in the framework of multiple international cooperation programs. Thus, a new digital accelerometer network was installed between 1996 and 1999 in cooperation with the Institute of Geophysics of the University of Karlsruhe (Germany), and an ample tomography experiment deployed for a 6-month time window (May - November 1999).The results obtained up to now refer to the determination of seismic source parameters and scaling. The source parameters are constrained using the spectral ratio technique and the seismic moment tensor inversion. The spectral ratio method is efficient when pairs of co-located earthquakes recorded at common stations are available. In this case the spectral ratio depends essentially on source only, and corrections for path, local response and instrument are not required. Another advantage of the method is the possibility to determine simultaneously source parameters for both selected events of a pair, if the instrument has a broadband frequency response and the signal/noise ratio is sufficiently high in the frequency domain of interest. The spectral ratio method is applied for 37 events, occurred between 1996 and 2000, with magnitudes between 3.0 and 5.3 in the intermediate-depth range. Seismic moment, source dimension and

  12. Cellulose-based porous scaffold for bone tissue engineering applications: Assessment of hMSC proliferation and differentiation.

    Science.gov (United States)

    Demitri, Christian; Raucci, Maria Grazia; Giuri, Antonella; De Benedictis, Vincenzo Maria; Giugliano, Daniela; Calcagnile, Paola; Sannino, Alessandro; Ambrosio, Luigi

    2016-03-01

    Physical foaming combined with microwave-induced curing was used in this study to develop an innovative device for bone tissue regeneration. In the first step of the process, a stable physical foaming was induced using a surfactant (i.e. pluronic) as blowing agent of a homogeneous blend of Sodium salt of carboxymethylcellulose (CMCNa) and polyethylene glycol diacrylate (PEGDA700) solution. In the second step, the porous structure of the scaffold was chemically stabilized by radical polymerization induced by a homogeneous rapid heating of the sample in a microwave reactor. In this step 2,2-Azobis[2-(2-imidazolin-2 yl)propane]Dihydrochloride was used as thermoinitiator (TI). CMCNa and PEGDA were mixed with different blends to correlate the properties of final product with the composition. The chemical properties of each sample were evaluated by spectroscopy analysis ATR-IR (before and after curing) in order to maximize reaction yield, and optimize kinetic parameters (i.e. time curing, microwave power). The stability of the materials was evaluated in vitro by degradation test in Phosphate Buffered Saline. Biological analyses were performed to evaluate the effect of scaffold materials on cellular behavior in terms of proliferation and early osteogenic differentiation of human Mesenchymal Stem Cells. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 726-733, 2016. © 2015 Wiley Periodicals, Inc.

  13. Assessment of chitosan-affected metabolic response by peroxisome proliferator-activated receptor bioluminescent imaging-guided transcriptomic analysis.

    Directory of Open Access Journals (Sweden)

    Chia-Hung Kao

    Full Text Available Chitosan has been widely used in food industry as a weight-loss aid and a cholesterol-lowering agent. Previous studies have shown that chitosan affects metabolic responses and contributes to anti-diabetic, hypocholesteremic, and blood glucose-lowering effects; however, the in vivo targeting sites and mechanisms of chitosan remain to be clarified. In this study, we constructed transgenic mice, which carried the luciferase genes driven by peroxisome proliferator-activated receptor (PPAR, a key regulator of fatty acid and glucose metabolism. Bioluminescent imaging of PPAR transgenic mice was applied to report the organs that chitosan acted on, and gene expression profiles of chitosan-targeted organs were further analyzed to elucidate the mechanisms of chitosan. Bioluminescent imaging showed that constitutive PPAR activities were detected in brain and gastrointestinal tract. Administration of chitosan significantly activated the PPAR activities in brain and stomach. Microarray analysis of brain and stomach showed that several pathways involved in lipid and glucose metabolism were regulated by chitosan. Moreover, the expression levels of metabolism-associated genes like apolipoprotein B (apoB and ghrelin genes were down-regulated by chitosan. In conclusion, these findings suggested the feasibility of PPAR bioluminescent imaging-guided transcriptomic analysis on the evaluation of chitosan-affected metabolic responses in vivo. Moreover, we newly identified that downregulated expression of apoB and ghrelin genes were novel mechanisms for chitosan-affected metabolic responses in vivo.

  14. Assessing the Value of Housing Schemes through Sustainable Return on Investment: A Path towards Sustainability-Led Evaluations?

    Directory of Open Access Journals (Sweden)

    Kevin Dean

    2017-12-01

    Full Text Available The 2016 United Nations (UN New Urban Agenda clearly reaffirms the concept that sustainable cities require intertwined environmental and social sustainability. The United Nations Sustainable Development Goal (SDG 11—“Make cities inclusive, safe, resilient, and sustainable”—sets (as a primary target the provision of sufficient affordable housing. Despite the central role that housing plays in ensuring sustainability and the importance of both environmental and social pillars in ensuring sustainable development, current evaluative methods that support decision making on social housing interventions fail to capture all of the socio-environmental value contained in the UN SDG 11. This paper addresses the issue by demonstrating how Sustainable Return on Investment can successfully describe and analyse a range of externalities related to the sustainable value generated by social housing regeneration schemes. To achieve this goal, a single case study strategy has been chosen. Two extant projects—a high-rise housing scheme and an environmental-led program developed by City West Housing Trust (a nonprofit housing association based in the Manchester area—have been assessed in order to monetise their social and environmental value through different methods. The findings show that, historically, the environmental and social value of regeneration schemes have been largely disregarded because of a gap in the evaluation methods, and that there is room for significant improvement for future evaluation exercises.

  15. Acquisition Path Analysis for a SFR Fuel Manufacturing Facility

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H. L.; Kwon, E. H.; Ahn, S. K.; Ko, W. I.; Kim, H. D. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The coarse acquisition path analysis does not claim to be complete, but it identifies plausible acquisition paths detailed enough to show that the acquisition path analysis can provide reasonable insights regarding the safeguardability assessment, and demonstrates the availability of safeguards tools and measures, although not complete, required for the implementation of effective and efficient safeguards, including the coverage of the nuclear energy system (NES) by multiple intrinsic features and extrinsic measures. It also identifies strengths, weaknesses and gaps of a system in the area of proliferation resistance in a generally understandable form. The acquisition path analysis demonstrates that all acceptance limits for the safeguardability, in principle, are met although the acceptance limit for the efficiency of the IAEA safeguards can be answered only at the end of the Safeguards-by-Design process, including interaction with IAEA operations. However, procedures for destructive assay (DA) for the verification by the IAEA are not defined. Target values for non-destructive assay (NDA) for this type of nuclear material are also not defined. Therefore, there is a need to finish demonstrations of NDA measurements on novel material types and material flows. The acquisition path analysis also shows some concerns that need to be assured in the system design process: e. g., the ID number of all storage containers in all storage positions can be read or checked without moving the storage container, transfer of TRU fuel and heel/scrap (product stream) should be strictly separated from transfer routes for waste, to make the transfer of TRU fuel and heel/scrap into waste container impossible, etc.

  16. Assessing the Effects of Grassland Management on Forage Production and Environmental Quality to Identify Paths to Ecological Intensification in Mountain Grasslands.

    Science.gov (United States)

    Loucougaray, Grégory; Dobremez, Laurent; Gos, Pierre; Pauthenet, Yves; Nettier, Baptiste; Lavorel, Sandra

    2015-11-01

    Ecological intensification in grasslands can be regarded as a process for increasing forage production while maintaining high levels of ecosystem functions and biodiversity. In the mountain Vercors massif, where dairy cattle farming is the main component of agriculture, how to achieve forage autonomy at farm level while sustaining environmental quality for tourism and local dairy products has recently stimulated local debate. As specific management is one of the main drivers of ecosystem functioning, we assessed the response of forage production and environmental quality at grassland scale across a wide range of management practices. We aimed to determine which components of management can be harnessed to better match forage production and environmental quality. We sampled the vegetation of 51 grasslands stratified across 13 grassland types. We assessed each grassland for agronomic and environmental properties, measuring forage production, forage quality, and indices based on the abundance of particular plant species such as timing flexibility, apiarian potential, and aromatic plants. Our results revealed an expected trade-off between forage production and environmental quality, notably by stressing the contrasts between sown and permanent grasslands. However, strong within-type variability in both production and environmental quality as well as in flexibility of timing of use suggests possible ways to improve this trade-off at grassland and farm scales. As achieving forage autonomy relies on increasing both forage production and grassland resilience, our results highlight the critical role of the ratio between sown and permanent grasslands as a major path for ecological intensification in mountain grasslands.

  17. Fissile material disposition and proliferation risk

    Energy Technology Data Exchange (ETDEWEB)

    Dreicer, J.S.; Rutherford, D.A. [Los Alamos National Lab., NM (United States). NIS Div.

    1996-05-01

    The proliferation risk of a facility is dependent on the material attractiveness, level of safeguards, and physical protection applied to the material in conjunction with an assessment of the impact of the socioeconomic circumstances and threat environment. Proliferation risk is a complementary extension of proliferation resistance. The authors believe a better determination of nuclear material proliferation can be achieved by establishing the proliferation risk for facilities that contain nuclear material. Developing a method that incorporates the socioeconomic circumstances and threat environment inherent to each country enables a global proliferation assessment. In order to effectively reduce the nuclear danger, a broadly based set of criteria is needed that provides the capability to relatively assess a wide range of disposition options/facilities in different countries and still ensure a global decrease in proliferation risk for plutonium.

  18. Fissile material disposition and proliferation risk

    International Nuclear Information System (INIS)

    Dreicer, J.S.; Rutherford, D.A.

    1996-01-01

    The proliferation risk of a facility is dependent on the material attractiveness, level of safeguards, and physical protection applied to the material in conjunction with an assessment of the impact of the socioeconomic circumstances and threat environment. Proliferation risk is a complementary extension of proliferation resistance. The authors believe a better determination of nuclear material proliferation can be achieved by establishing the proliferation risk for facilities that contain nuclear material. Developing a method that incorporates the socioeconomic circumstances and threat environment inherent to each country enables a global proliferation assessment. In order to effectively reduce the nuclear danger, a broadly based set of criteria is needed that provides the capability to relatively assess a wide range of disposition options/facilities in different countries and still ensure a global decrease in proliferation risk for plutonium

  19. Proliferation assessment in breast carcinomas using digital image analysis based on virtual Ki67/cytokeratin double staining.

    Science.gov (United States)

    Røge, Rasmus; Riber-Hansen, Rikke; Nielsen, Søren; Vyberg, Mogens

    2016-07-01

    Manual estimation of Ki67 Proliferation Index (PI) in breast carcinoma classification is labor intensive and prone to intra- and interobserver variation. Standard Digital Image Analysis (DIA) has limitations due to issues with tumor cell identification. Recently, a computer algorithm, DIA based on Virtual Double Staining (VDS), segmenting Ki67-positive and -negative tumor cells using digitally fused parallel cytokeratin (CK) and Ki67-stained slides has been introduced. In this study, we compare VDS with manual stereological counting of Ki67-positive and -negative cells and examine the impact of the physical distance of the parallel slides on the alignment of slides. TMAs, containing 140 cores of consecutively obtained breast carcinomas, were stained for CK and Ki67 using optimized staining protocols. By means of stereological principles, Ki67-positive and -negative cell profiles were counted in sampled areas and used for the estimation of PIs of the whole tissue core. The VDS principle was applied to both the same sampled areas and the whole tissue core. Additionally, five neighboring slides were stained for CK in order to examine the alignment algorithm. Correlation between manual counting and VDS in both sampled areas and whole core was almost perfect (correlation coefficients above 0.97). Bland-Altman plots did not reveal any skewness in any data ranges. There was a good agreement in alignment (>85 %) in neighboring slides, whereas agreement decreased in non-neighboring slides. VDS gave similar results compared with manual counting using stereological principles. Introduction of this method in clinical and research practice may improve accuracy and reproducibility of Ki67 PI.

  20. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest.

  1. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    International Nuclear Information System (INIS)

    1980-06-01

    This volume of the Nonproliferation Alternative Systems Assessment Program (NASAP) report provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

  2. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IV. Commercial potential

    International Nuclear Information System (INIS)

    1979-12-01

    Volume IV provides time and cost estimates for positioning new nuclear power systems for commercial deployment. The assessment also estimates the rates at which the new systems might penetrate the domestic market, assuming the continuing viability of the massive light-water reactor network that now exists worldwide. This assessment does not recommend specific, detailed program plans and budgets for individual systems; however, it is clear from this analysis that any of the systems investigated could be deployed if dictated by national interest

  3. World nuclear energy paths

    International Nuclear Information System (INIS)

    Connolly, T.J.; Hansen, U.; Jaek, W.; Beckurts, K.H.

    1979-01-01

    In examing the world nuclear energy paths, the following assumptions were adopted: the world economy will grow somewhat more slowly than in the past, leading to reductions in electricity demand growth rates; national and international political impediments to the deployment of nuclear power will gradually disappear over the next few years; further development of nuclear power will proceed steadily, without serious interruption but with realistic lead times for the introduction of advanced technologies. Given these assumptions, this paper attempts a study of possible world nuclear energy developments, disaggregated on a regional and national basis. The scenario technique was used and a few alternative fuel-cycle scenarios were developed. Each is an internally consistent model of technically and economically feasible paths to the further development of nuclear power in an aggregate of individual countries and regions of the world. The main purpose of this modeling exercise was to gain some insight into the probable international locations of reactors and other nuclear facilities, the future requirements for uranium and for fuel-cycle services, and the problems of spent-fuel storage and waste management. The study also presents an assessment of the role that nuclear power might actually play in meeting future world energy demand

  4. Nuclear Proliferation Technology Trends Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Zentner, Michael D.; Coles, Garill A.; Talbert, Robert J.

    2005-10-04

    A process is underway to develop mature, integrated methodologies to address nonproliferation issues. A variety of methodologies (both qualitative and quantitative) are being considered. All have one thing in common, a need for a consistent set of proliferation related data that can be used as a basis for application. One approach to providing a basis for predicting and evaluating future proliferation events is to understand past proliferation events, that is, the different paths that have actually been taken to acquire or attempt to acquire special nuclear material. In order to provide this information, this report describing previous material acquisition activities (obtained from open source material) has been prepared. This report describes how, based on an evaluation of historical trends in nuclear technology development, conclusions can be reached concerning: (1) The length of time it takes to acquire a technology; (2) The length of time it takes for production of special nuclear material to begin; and (3) The type of approaches taken for acquiring the technology. In addition to examining time constants, the report is intended to provide information that could be used to support the use of the different non-proliferation analysis methodologies. Accordingly, each section includes: (1) Technology description; (2) Technology origin; (3) Basic theory; (4) Important components/materials; (5) Technology development; (6) Technological difficulties involved in use; (7) Changes/improvements in technology; (8) Countries that have used/attempted to use the technology; (9) Technology Information; (10) Acquisition approaches; (11) Time constants for technology development; and (12) Required Concurrent Technologies.

  5. Assessment of in vitro COPD models for tobacco regulatory science: Workshop proceedings, conclusions and paths forward for in vitro model use.

    Science.gov (United States)

    Behrsing, Holger; Raabe, Hans; Manuppello, Joseph; Bombick, Betsy; Curren, Rodger; Sullivan, Kristie; Sethi, Sanjay; Phipps, Richard; Tesfaigzi, Yohannes; Yan, Sherwin; D'Ruiz, Carl; Tarran, Robert; Constant, Samuel; Phillips, Gary; Gaça, Marianna; Hayden, Patrick; Cao, Xuefei; Mathis, Carole; Hoeng, Julia; Braun, Armin; Hill, Erin

    2016-05-01

    The Family Smoking Prevention and Tobacco Control Act of 2009 established the Food and Drug Administration Center for Tobacco Products (FDA-CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed 'modified risk'. On 8-10 December 2014, IIVS organised a workshop conference, entitled Assessment of In Vitro COPD Models for Tobacco Regulatory Science, to bring together stakeholders representing regulatory agencies, academia, industry and animal protection, to address the research priorities articulated by the FDA-CTP. Specific topics were covered to assess the status of current in vitro technologies as they are applied to understanding the adverse pulmonary events resulting from tobacco product exposure, and in particular, the progression of chronic obstructive pulmonary disease (COPD). The four topics covered were: a) Inflammation and Oxidative Stress; b) Ciliary Dysfunction and Ion Transport; c) Goblet Cell Hyperplasia and Mucus Production; and d) Parenchymal/Bronchial Tissue Destruction and Remodelling. The 2.5 day workshop included 18 expert speakers, plus poster sessions, networking and breakout sessions, which identified key findings and provided recommendations to advance the in vitro technologies and assays used to evaluate tobacco-induced disease etiologies. The workshop summary was reported at the 2015 Society of Toxicology Annual Meeting, and the recommendations led to an IIVS-organised technical workshop in June 2015, entitled Goblet Cell Hyperplasia, Mucus Production, and Ciliary Beating Assays, to assess these assays and to conduct a proof-of-principle multi-laboratory exercise to determine their suitability for standardisation. Here, we report on the proceedings, recommendations and outcomes of the December 2014 workshop, including paths forward to continue the development of non-animal methods to evaluate tissue responses that model the disease processes that may lead to COPD, a

  6. Theoretical Approaches to Nuclear Proliferation

    Directory of Open Access Journals (Sweden)

    Konstantin S. Tarasov

    2015-01-01

    Full Text Available This article analyses discussions between representatives of three schools in the theory of international relations - realism, liberalism and constructivism - on the driving factors of nuclear proliferation. The paper examines major theoretical approaches, outlined in the studies of Russian and foreign scientists, to the causes of nuclear weapons development, while unveiling their advantages and limitations. Much of the article has been devoted to alternative approaches, particularly, the role of mathematical modeling in assessing proliferation risks. The analysis also reveals a variety of different approaches to nuclear weapons acquisition, as well as the absence of a comprehensive proliferation theory. Based on the research results the study uncovers major factors both favoring and impeding nuclear proliferation. The author shows that the lack of consensus between realists, liberals and constructivists on the nature of proliferation led a number of scientists to an attempt to explain nuclear rationale by drawing from the insights of more than one school in the theory of IR. Detailed study of the proliferation puzzle contributes to a greater understating of contemporary international realities, helps to identify mechanisms that are most likely to deter states from obtaining nuclear weapons and is of the outmost importance in predicting short- and long-term security environment. Furthermore, analysis of the existing scientific literature on nuclear proliferation helps to determine future research agenda of the subject at hand.

  7. Fractional path planning and path tracking

    International Nuclear Information System (INIS)

    Melchior, P.; Jallouli-Khlif, R.; Metoui, B.

    2011-01-01

    This paper presents the main results of the application of fractional approach in path planning and path tracking. A new robust path planning design for mobile robot was studied in dynamic environment. The normalized attractive force applied to the robot is based on a fictitious fractional attractive potential. This method allows to obtain robust path planning despite robot mass variation. The danger level of each obstacles is characterized by the fractional order of the repulsive potential of the obstacles. Under these conditions, the robot dynamic behavior was studied by analyzing its X - Y path planning with dynamic target or dynamic obstacles. The case of simultaneously mobile obstacles and target is also considered. The influence of the robot mass variation is studied and the robustness analysis of the obtained path shows the robustness improvement due to the non integer order properties. Pre shaping approach is used to reduce system vibration in motion control. Desired systems inputs are altered so that the system finishes the requested move without residual vibration. This technique, developed by N.C. Singer and W.P.Seering, is used for flexible structure control, particularly in the aerospace field. In a previous work, this method was extended for explicit fractional derivative systems and applied to second generation CRONE control, the robustness was also studied. CRONE (the French acronym of C ommande Robuste d'Ordre Non Entier ) control system design is a frequency-domain based methodology using complex fractional integration.

  8. Association of Noncigarette Tobacco Product Use With Future Cigarette Smoking Among Youth in the Population Assessment of Tobacco and Health (PATH) Study, 2013-2015.

    Science.gov (United States)

    Watkins, Shannon Lea; Glantz, Stanton A; Chaffee, Benjamin W

    2018-02-01

    Approximately 90% of adult smokers first tried a cigarette by 18 years of age, and even infrequent smoking in adolescence is associated with established adult smoking. Noncigarette tobacco use is increasing and could stimulate subsequent conventional cigarette smoking in youths. To estimate the longitudinal association between noncigarette tobacco use and subsequent cigarette smoking initiation among US youth. In this prospective cohort study of the Population Assessment of Tobacco and Health (PATH) waves 1 (September 12, 2013, to December 14, 2014) and 2 (October 23, 2014, to October 30, 2015), a nationally representative sample of youths who never smoked a conventional cigarette at baseline and completed wave 2 follow-up (N = 10 384) was studied. PATH retention at follow-up was 87.9%. Ever use and past 30-day use of electronic cigarettes (e-cigarettes), hookah, noncigarette combustible tobacco, or smokeless tobacco at baseline. Ever use and past 30-day use of cigarettes at follow-up. The present analysis was based on the 10 384 PATH youth respondents who reported never having smoked a cigarette in wave 1 and whose cigarette ever or past 30-day use was reported in wave 2 (mean [SD] age, 14.3 [1.7] years; age range, 12-17 years; 5087 [49.1%] female; 4829 [52.5%] white). At 1-year follow-up, 469 (4.6%) of all baseline never-smoking youths had tried a cigarette and 219 (2.1%) had smoked a cigarette within the past 30 days. Cigarette ever use at follow-up was higher among youths who had ever used e-cigarettes (78 [19.1%]), hookah (60 [18.3%]), noncigarette combustible tobacco (45 [19.2%]), or smokeless tobacco (29 [18.8%]) at baseline. After adjusting for sociodemographic, environmental, and behavioral smoking risk factors and for baseline ever use of other tobacco products, the odds of past 30-day cigarette use at follow-up were approximately twice as high among baseline ever users of e-cigarettes (odds ratio [OR], 1.87; 95% CI, 1.15-3.05), hookah (OR, 1

  9. Assessment of estradiol-induced gene regulation and proliferation in an immortalized mouse immature Sertoli cell line.

    Science.gov (United States)

    Kumar, Narender; Srivastava, Swati; Burek, Malgorzata; Förster, Carola Y; Roy, Partha

    2016-03-01

    The number of Sertoli cells during proliferative phase determines the fate of the germ cells in male reproductive system. A well-characterized cell line may help in better understanding of Sertoli cell biology. Hence, the present study assessed estradiol signaling in a mouse immature Sertoli cell line (MSC-1) as an alternative model in place of primary culture of Sertoli cells. In this study, we used MSC-1 cell line, derived from 10-day old mice. The cell cycle parameters were assessed, and the expression and regulation of Sertoli cell-specific secretory genes (ABP; androgen-binding protein) and tight junction genes (claudin-5, occludin, and vimentin) in response to estradiol was studied. The results obtained suggested the presence of both estrogen receptors (ERα and ERβ) in MSC-1 cells. In vitro scratch assay and cell-cycle analysis suggested the proliferative effects of estradiol in both time- and dose-dependent manner. The gene expression profiles of ABP, claudin-5, and occludin showed biphasic regulation at low and high doses of estradiol. Analysis of signaling pathways suggested the activation of extracellular signal-regulated kinase (ERK) pathway with significantly increased pERK/ERK ratio (p<0.05). The results also suggested down regulation in the expression of mir-17 family members (mir-17, mir-20b, and mir-106a) (p<0.05). Considering the limited number of Sertoli cell lines and long-term survival inability of primary culture of Sertoli cells, MSC-1 cells could be a potential cell line for understanding the mechanisms of various cellular events in Sertoli cells. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Path-dependent functions

    International Nuclear Information System (INIS)

    Khrapko, R.I.

    1985-01-01

    A uniform description of various path-dependent functions is presented with the help of expansion of the type of the Taylor series. So called ''path-integrals'' and ''path-tensor'' are introduced which are systems of many-component quantities whose values are defined for arbitrary paths in coordinated region of space in such a way that they contain a complete information on the path. These constructions are considered as elementary path-dependent functions and are used instead of power monomials in the usual Taylor series. Coefficients of such an expansion are interpreted as partial derivatives dependent on the order of the differentiations or else as nonstandard cavariant derivatives called two-point derivatives. Some examples of pathdependent functions are presented.Space curvature tensor is considered whose geometrica properties are determined by the (non-transitive) translator of parallel transport of a general type. Covariant operation leading to the ''extension'' of tensor fiels is pointed out

  11. Iterated Leavitt Path Algebras

    International Nuclear Information System (INIS)

    Hazrat, R.

    2009-11-01

    Leavitt path algebras associate to directed graphs a Z-graded algebra and in their simplest form recover the Leavitt algebras L(1,k). In this note, we introduce iterated Leavitt path algebras associated to directed weighted graphs which have natural ± Z grading and in their simplest form recover the Leavitt algebras L(n,k). We also characterize Leavitt path algebras which are strongly graded. (author)

  12. Misperceptions of harm among Natural American Spirit smokers: results from wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013-2014).

    Science.gov (United States)

    Pearson, Jennifer L; Johnson, Amanda; Villanti, Andrea; Glasser, Allison M; Collins, Lauren; Cohn, Amy; Rose, Shyanika W; Niaura, Raymond; Stanton, Cassandra A

    2017-03-01

    This study estimated differences in cigarette harm perceptions among smokers of the Natural American Spirit (NAS) brand-marketed as 'natural', 'organic' and 'additive-free'-compared to other smokers, and examined correlates of NAS use. Data were drawn from wave 1 of the Population Assessment of Tobacco and Health (PATH) study, a nationally representative study of US adults (2013-2014). Weighted analyses using a subset of current adult smokers (n=10 565) estimated the prevalence of NAS use (vs all other brands) and examined associations between NAS use and sociodemographics, tobacco/substance use, tobacco harm perceptions, quit intentions, quit attempts and mental/behavioural health. Overall, 2.3% of adult smokers (920 000 people in the USA) reported NAS as their usual brand. Nearly 64% of NAS smokers inaccurately believed that their brand is less harmful than other brands compared to 8.3% of smokers of other brands, after controlling for potential confounders (aOR 22.82). Younger age (18-34 vs 35+; aOR 1.54), frequent thinking about tobacco harms (aOR 1.84), past 30-day alcohol use (aOR 1.57), past 30-day marijuana use (aOR 1.87) and sexual orientation (lesbian, gay, bisexual, 'other' or 'questioning' vs heterosexual; aOR 2.07) were also associated with increased odds of smoking NAS. The majority of NAS smokers inaccurately believes that their cigarettes are less harmful than other brands. Given the brand's rapid growth and its more common use in vulnerable groups (eg, young adults, lesbian, gay, bisexual, 'other' or 'questioning' adults), corrective messaging and enforcement action are necessary to correct harm misperceptions of NAS cigarettes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  13. Pulled Motzkin paths

    Energy Technology Data Exchange (ETDEWEB)

    Janse van Rensburg, E J, E-mail: rensburg@yorku.c [Department of Mathematics and Statistics, York University, Toronto, ON, M3J 1P3 (Canada)

    2010-08-20

    In this paper the models of pulled Dyck paths in Janse van Rensburg (2010 J. Phys. A: Math. Theor. 43 215001) are generalized to pulled Motzkin path models. The generating functions of pulled Motzkin paths are determined in terms of series over trinomial coefficients and the elastic response of a Motzkin path pulled at its endpoint (see Orlandini and Whittington (2004 J. Phys. A: Math. Gen. 37 5305-14)) is shown to be R(f) = 0 for forces pushing the endpoint toward the adsorbing line and R(f) = f(1 + 2cosh f))/(2sinh f) {yields} f as f {yields} {infinity}, for forces pulling the path away from the X-axis. In addition, the elastic response of a Motzkin path pulled at its midpoint is shown to be R(f) = 0 for forces pushing the midpoint toward the adsorbing line and R(f) = f(1 + 2cosh (f/2))/sinh (f/2) {yields} 2f as f {yields} {infinity}, for forces pulling the path away from the X-axis. Formal combinatorial identities arising from pulled Motzkin path models are also presented. These identities are the generalization of combinatorial identities obtained in directed paths models to their natural trinomial counterparts.

  14. Pulled Motzkin paths

    Science.gov (United States)

    Janse van Rensburg, E. J.

    2010-08-01

    In this paper the models of pulled Dyck paths in Janse van Rensburg (2010 J. Phys. A: Math. Theor. 43 215001) are generalized to pulled Motzkin path models. The generating functions of pulled Motzkin paths are determined in terms of series over trinomial coefficients and the elastic response of a Motzkin path pulled at its endpoint (see Orlandini and Whittington (2004 J. Phys. A: Math. Gen. 37 5305-14)) is shown to be R(f) = 0 for forces pushing the endpoint toward the adsorbing line and R(f) = f(1 + 2cosh f))/(2sinh f) → f as f → ∞, for forces pulling the path away from the X-axis. In addition, the elastic response of a Motzkin path pulled at its midpoint is shown to be R(f) = 0 for forces pushing the midpoint toward the adsorbing line and R(f) = f(1 + 2cosh (f/2))/sinh (f/2) → 2f as f → ∞, for forces pulling the path away from the X-axis. Formal combinatorial identities arising from pulled Motzkin path models are also presented. These identities are the generalization of combinatorial identities obtained in directed paths models to their natural trinomial counterparts.

  15. Pulled Motzkin paths

    International Nuclear Information System (INIS)

    Janse van Rensburg, E J

    2010-01-01

    In this paper the models of pulled Dyck paths in Janse van Rensburg (2010 J. Phys. A: Math. Theor. 43 215001) are generalized to pulled Motzkin path models. The generating functions of pulled Motzkin paths are determined in terms of series over trinomial coefficients and the elastic response of a Motzkin path pulled at its endpoint (see Orlandini and Whittington (2004 J. Phys. A: Math. Gen. 37 5305-14)) is shown to be R(f) = 0 for forces pushing the endpoint toward the adsorbing line and R(f) = f(1 + 2cosh f))/(2sinh f) → f as f → ∞, for forces pulling the path away from the X-axis. In addition, the elastic response of a Motzkin path pulled at its midpoint is shown to be R(f) = 0 for forces pushing the midpoint toward the adsorbing line and R(f) = f(1 + 2cosh (f/2))/sinh (f/2) → 2f as f → ∞, for forces pulling the path away from the X-axis. Formal combinatorial identities arising from pulled Motzkin path models are also presented. These identities are the generalization of combinatorial identities obtained in directed paths models to their natural trinomial counterparts.

  16. Characteristics of Hookah Tobacco Smoking Sessions and Correlates of Use Frequency Among US Adults: Findings From Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study.

    Science.gov (United States)

    Robinson, Joelle N; Wang, Baoguang; Jackson, Kia J; Donaldson, Elisabeth A; Ryant, Chase A

    2018-05-03

    Hookah tobacco smoking has increased in the United States. However, information on hookah use frequency and other characteristics of hookah use is limited. Investigators analyzed data from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative, longitudinal cohort study of US youth and adults. Our analysis draws on baseline data from adult (ages ≥18 years) ever (N = 10 624) and past year (n = 3947) hookah users. Bivariate and regression analyses were conducted to identify associations between demographics, use characteristics, and hookah use frequency. Overall, 16.4% of adults reported ever smoking tobacco from a hookah. Of those, 31.9% reported smoking hookah within the past year. Among 3947 past-year hookah tobacco smokers, 10.7% were daily/weekly users, 13.7% were monthly users, 42.1% smoked every couple of months, and 33.5% smoked about once a year. Among daily/weekly hookah users, 66% were young adults (ages 18-24 years). When comparing daily/weekly hookah users to those who smoked every couple of months, more frequent hookah use was associated with younger age, male gender, a greater number of times the hookah is refilled during a session, fewer people sharing, and hookah ownership. Although there were few demographic differences between daily/weekly users and less frequent hookah tobacco smokers, some notable differences in use behaviors exist among use frequency groups. Unlike other tobacco products, hookah is often smoked communally, over an extended time period. A detailed understanding of hookah user characteristics and experiences could inform hookah-specific measures, messaging, and regulations. To our knowledge, this is one of the first studies to characterize hookah use frequency, session length, and other hookah use experiences using a nationally representative sample of US adult hookah smokers. Understanding characteristics of hookah tobacco smokers, their use experiences, and patterns of hookah use

  17. Multi-Dimensional Path Queries

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    1998-01-01

    to create nested path structures. We present an SQL-like query language that is based on path expressions and we show how to use it to express multi-dimensional path queries that are suited for advanced data analysis in decision support environments like data warehousing environments......We present the path-relationship model that supports multi-dimensional data modeling and querying. A path-relationship database is composed of sets of paths and sets of relationships. A path is a sequence of related elements (atoms, paths, and sets of paths). A relationship is a binary path...

  18. Ductility behavior of irradiated path B alloys

    International Nuclear Information System (INIS)

    Yang, W.J.S.; Hamilton, M.L.

    1983-01-01

    The objective of this study was to assess the practicality of using five Path B alloys in their current form as structural materials in the Fusion First-Wall/Blanket by evaluating both their postirradiation ductility and the corresponding microstructures

  19. Unique Path Partitions

    DEFF Research Database (Denmark)

    Bessenrodt, Christine; Olsson, Jørn Børling; Sellers, James A.

    2013-01-01

    We give a complete classification of the unique path partitions and study congruence properties of the function which enumerates such partitions.......We give a complete classification of the unique path partitions and study congruence properties of the function which enumerates such partitions....

  20. Hamiltonian path integrals

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1982-01-01

    The properties of path integrals associated with the allowance for nonstandard terms reflecting the operator nature of the canonical variables are considered. Rules for treating such terms (''equivalence rules'') are formulated. Problems with a boundary, the behavior of path integrals under canonical transformations, and the problem of quantization of dynamical systems with constraints are considered in the framework of the method

  1. Noninvasive quantification of 18F-FLT human brain PET for the assessment of tumour proliferation in patients with high-grade glioma

    International Nuclear Information System (INIS)

    Backes, Heiko; Ullrich, Roland; Neumaier, Bernd; Kracht, Lutz; Wienhard, Klaus; Jacobs, Andreas H.

    2009-01-01

    Compartmental modelling of 3 ' -deoxy-3 ' -[ 18 F]-fluorothymidine ( 18 F-FLT) PET-derived kinetics provides a method for noninvasive assessment of the proliferation rate of gliomas. Such analyses, however, require an input function generally derived by serial blood sampling and counting. In the current study, 18 F-FLT kinetic parameters obtained from image-derived input functions were compared with those from input functions derived from arterialized blood samples. Based on the analysis of 11 patients with glioma (WHO grade II-IV) a procedure for the automated extraction of an input function from 18 F-FLT brain PET data was derived. The time-activity curve of the volume of interest with the maximum difference in 18 F-FLT uptake during the first 5 min after injection and the period from 60 to 90 min was corrected for partial-volume effects and in vivo metabolism of 18 F-FLT. For each patient a two-compartment kinetic model was applied to the tumour tissue using the image-derived input function. The resulting kinetic rate constants K 1 (transport across the blood-brain barrier) and K i (metabolic rate constant or net influx constant) were compared with those obtained from the same data using the input function derived from blood samples. Additionally, the metabolic rate constant was correlated with the frequency of tumour cells stained with Ki-67, a widely used immunohistochemical marker of cell proliferation. The rate constants from kinetic modelling were comparable when the blood sample-derived input functions were replaced by the image-derived functions (K 1,img and K 1,sample , r = 0.95, p -5 ; K i,img and K i,sample , r = 0.86, p 1,img and K 1,sample , p = 0.20; K i,img and K i,sample , p = 0.92). Furthermore, a significant correlation between K i,img and the percentage of Ki-67-positive cells was observed (r = 0.73, p = 0.01). Kinetic modelling of 18 F-FLT brain PET data using image-derived input functions extracted from human brain PET data with the practical

  2. The threat of proliferation

    International Nuclear Information System (INIS)

    Palme, Olof.

    1986-01-01

    The paper on the threat of proliferation, is a keynote speech delivered to the Colloquium on Nuclear War, Nuclear Proliferation and their Consequences, Geneva, 1985. Topics discussed in the address include: nuclear weapons, nuclear war, terrorists, Non-Proliferation Treaty, nuclear disarmament, and leadership in world affairs. (UK)

  3. Security Guarantees and Nuclear Non-Proliferation

    International Nuclear Information System (INIS)

    Bruno Tertrais

    2011-01-01

    The purpose of this paper is to discuss the value of 'security guarantees', that is, positive security assurances that include a formal or informal defense commitment, in preventing nuclear proliferation. It demonstrates that such guarantees have proven to be a very effective instrument in preventing States from going nuclear. It would thus seem logical to reinforce or extend them. However, this path is fraught with obstacles and dilemmas

  4. Security Guarantees and Nuclear Non-Proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Bruno Tertrais

    2011-07-01

    The purpose of this paper is to discuss the value of 'security guarantees', that is, positive security assurances that include a formal or informal defense commitment, in preventing nuclear proliferation. It demonstrates that such guarantees have proven to be a very effective instrument in preventing States from going nuclear. It would thus seem logical to reinforce or extend them. However, this path is fraught with obstacles and dilemmas

  5. Path integration quantization

    International Nuclear Information System (INIS)

    DeWitt-Morette, C.

    1983-01-01

    Much is expected of path integration as a quantization procedure. Much more is possible if one recognizes that path integration is at the crossroad of stochastic and differential calculus and uses the full power of both stochastic and differential calculus in setting up and computing path integrals. In contrast to differential calculus, stochastic calculus has only comparatively recently become an instrument of thought. It has nevertheless already been used in a variety of challenging problems, for instance in the quantization problem. The author presents some applications of the stochastic scheme. (Auth.)

  6. Two dimensional simplicial paths

    International Nuclear Information System (INIS)

    Piso, M.I.

    1994-07-01

    Paths on the R 3 real Euclidean manifold are defined as 2-dimensional simplicial strips which are orbits of the action of a discrete one-parameter group. It is proven that there exists at least one embedding of R 3 in the free Z-module generated by S 2 (x 0 ). The speed is defined as the simplicial derivative of the path. If mass is attached to the simplex, the free Lagrangian is proportional to the width of the path. In the continuum limit, the relativistic form of the Lagrangian is recovered. (author). 7 refs

  7. Zero-Slack, Noncritical Paths

    Science.gov (United States)

    Simons, Jacob V., Jr.

    2017-01-01

    The critical path method/program evaluation and review technique method of project scheduling is based on the importance of managing a project's critical path(s). Although a critical path is the longest path through a network, its location in large projects is facilitated by the computation of activity slack. However, logical fallacies in…

  8. Groebner Finite Path Algebras

    OpenAIRE

    Leamer, Micah J.

    2004-01-01

    Let K be a field and Q a finite directed multi-graph. In this paper I classify all path algebras KQ and admissible orders with the property that all of their finitely generated ideals have finite Groebner bases. MS

  9. Path planning in changeable environments

    NARCIS (Netherlands)

    Nieuwenhuisen, D.

    2007-01-01

    This thesis addresses path planning in changeable environments. In contrast to traditional path planning that deals with static environments, in changeable environments objects are allowed to change their configurations over time. In many cases, path planning algorithms must facilitate quick

  10. Assessing flow paths in a karst aquifer based on multiple dye tracing tests using stochastic simulation and the MODFLOW-CFP code

    Science.gov (United States)

    Assari, Amin; Mohammadi, Zargham

    2017-09-01

    Karst systems show high spatial variability of hydraulic parameters over small distances and this makes their modeling a difficult task with several uncertainties. Interconnections of fractures have a major role on the transport of groundwater, but many of the stochastic methods in use do not have the capability to reproduce these complex structures. A methodology is presented for the quantification of tortuosity using the single normal equation simulation (SNESIM) algorithm and a groundwater flow model. A training image was produced based on the statistical parameters of fractures and then used in the simulation process. The SNESIM algorithm was used to generate 75 realizations of the four classes of fractures in a karst aquifer in Iran. The results from six dye tracing tests were used to assign hydraulic conductivity values to each class of fractures. In the next step, the MODFLOW-CFP and MODPATH codes were consecutively implemented to compute the groundwater flow paths. The 9,000 flow paths obtained from the MODPATH code were further analyzed to calculate the tortuosity factor. Finally, the hydraulic conductivity values calculated from the dye tracing experiments were refined using the actual flow paths of groundwater. The key outcomes of this research are: (1) a methodology for the quantification of tortuosity; (2) hydraulic conductivities, that are incorrectly estimated (biased low) with empirical equations that assume Darcian (laminar) flow with parallel rather than tortuous streamlines; and (3) an understanding of the scale-dependence and non-normal distributions of tortuosity.

  11. Noninvasive assessment of cell proliferation in ovarian cancer using [18F] 3'deoxy-3-fluorothymidine positron emission tomography/computed tomography imaging

    International Nuclear Information System (INIS)

    Richard, Scott D.; Bencherif, Badreddine; Edwards, Robert P.; Elishaev, Esther; Krivak, Thomas C.; Mountz, James M.; DeLoia, Julie A.

    2011-01-01

    Introduction: Positron emission tomography (PET)/computed tomography (CT) imaging of suspected new and recurrent ovarian carcinoma was performed to assess the relationship between [ 18 F] 3'deoxy-3'fluorothymidine ( 18 FLT) uptake and histopathological tissue markers of cellular proliferation (Ki67) and thymidine kinase-1 (TK-1) expression. Methods: Six subjects were included in this pilot study. Subjects were injected with 5 mCi of 18 FLT prior to a planned surgery and then scanned on a GE Discovery-ST PET/CT scanner within an hour of injection. Regions of interest in tumor and control tissue were identified on the diagnostic CT scans and marked for later surgical biopsy. Surgery was performed within 2 days after the scan. At the time of surgery, the regions of interest identified on PET/CT were available to guide the surgeon to the tumor biopsy sites. Tissue from normal ovarian tissue control regions was also sampled. 18 FLT uptake in tumor and control tissue regions was calculated by measuring the maximum standardized uptake values (SUV max ). The excised tumor and normal ovarian tissue control tissues were analyzed by immunohistochemical staining for Ki67 and CD34. TK-1 messenger RNA expression was measured by real-time polymerase chain reaction. Results: 18 FLT uptake (SUV max ) was higher in malignant (mean 4.85/range 1.7-8.8) compared to benign (1.65/range 1.4-1.9) and normal ovarian control tissue (1.12/range 0.6-1.5). Mitotic index, as determined by Ki67 staining, was higher in malignant (18.89/range 11.97-27.19) compared to benign (0.59/range 0.23-0.95) and control tissue (0.45/range 0.06-1.20). TK-1 expression was also higher in malignant (35.52/range 5.21-106.62) compared to benign (8.71/range 4.74-12.67) and control tissue (9.79/range 0.85-39.46). An increasing trend between 18 FLT uptake and Ki67 mitotic index is seen in malignant tissue CD 34 staining between malignant, benign and control tissues was not qualitatively different. Conclusion: An

  12. Noninvasive assessment of cell proliferation in ovarian cancer using [{sup 18}F] 3'deoxy-3-fluorothymidine positron emission tomography/computed tomography imaging

    Energy Technology Data Exchange (ETDEWEB)

    Richard, Scott D. [Department of Obstetrics, Gynecology and Reproductive Services, Division of Gynecologic Oncology, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Bencherif, Badreddine, E-mail: bencherifbb@upmc.ed [Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Edwards, Robert P. [Department of Obstetrics, Gynecology and Reproductive Services, Division of Gynecologic Oncology, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Elishaev, Esther [Department of Obstetrics, Gynecology and Reproductive Services, Division of Gynecologic Oncology, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213 (United States); Krivak, Thomas C.; Mountz, James M. [Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213 (United States); DeLoia, Julie A. [Department of Obstetrics, Gynecology and Reproductive Services, Division of Gynecologic Oncology, University of Pittsburgh, Pittsburgh, PA 15213 (United States)

    2011-05-15

    Introduction: Positron emission tomography (PET)/computed tomography (CT) imaging of suspected new and recurrent ovarian carcinoma was performed to assess the relationship between [{sup 18}F] 3'deoxy-3'fluorothymidine ({sup 18}FLT) uptake and histopathological tissue markers of cellular proliferation (Ki67) and thymidine kinase-1 (TK-1) expression. Methods: Six subjects were included in this pilot study. Subjects were injected with 5 mCi of {sup 18}FLT prior to a planned surgery and then scanned on a GE Discovery-ST PET/CT scanner within an hour of injection. Regions of interest in tumor and control tissue were identified on the diagnostic CT scans and marked for later surgical biopsy. Surgery was performed within 2 days after the scan. At the time of surgery, the regions of interest identified on PET/CT were available to guide the surgeon to the tumor biopsy sites. Tissue from normal ovarian tissue control regions was also sampled. {sup 18}FLT uptake in tumor and control tissue regions was calculated by measuring the maximum standardized uptake values (SUV{sub max}). The excised tumor and normal ovarian tissue control tissues were analyzed by immunohistochemical staining for Ki67 and CD34. TK-1 messenger RNA expression was measured by real-time polymerase chain reaction. Results: {sup 18}FLT uptake (SUV{sub max}) was higher in malignant (mean 4.85/range 1.7-8.8) compared to benign (1.65/range 1.4-1.9) and normal ovarian control tissue (1.12/range 0.6-1.5). Mitotic index, as determined by Ki67 staining, was higher in malignant (18.89/range 11.97-27.19) compared to benign (0.59/range 0.23-0.95) and control tissue (0.45/range 0.06-1.20). TK-1 expression was also higher in malignant (35.52/range 5.21-106.62) compared to benign (8.71/range 4.74-12.67) and control tissue (9.79/range 0.85-39.46). An increasing trend between {sup 18}FLT uptake and Ki67 mitotic index is seen in malignant tissue CD 34 staining between malignant, benign and control tissues was not

  13. Proliferation: myth or reality?

    International Nuclear Information System (INIS)

    2005-01-01

    This article analyzes the proliferation approach, its technical condition and political motivation, and the share between the myth (political deception, assumptions and extrapolations) and the reality of proliferation. Its appreciation is complicated by the irrational behaviour of some political actors and by the significant loss of the non-use taboo. The control of technologies is an important element for proliferation slowing down but an efficient and autonomous intelligence system remains indispensable. (J.S.)

  14. Intelligence and Nuclear Proliferation: Lessons Learned

    International Nuclear Information System (INIS)

    Hansen, Keith A.

    2011-09-01

    Intelligence agencies play a fundamental role in the prevention of nuclear proliferation, as they help to understand other countries' intentions and assess their technical capabilities and the nature of their nuclear activities. The challenges in this area remain, however, formidable. Past experiences and the discoveries of Iraq's WMD programs, of North Korean nuclear weapon program, and of Iranian activities, have put into question the ability of intelligence to monitor small, clandestine proliferation activities from either states or non-state entities. This Proliferation Paper analyzes the complex challenges intelligence faces and the various roles it plays in supporting national and international nuclear non-proliferation efforts, and reviews its track record. In an effort to shed light on the role and contribution of intelligence in national and international efforts to halt, if not prevent, further nuclear weapon proliferation, this paper first analyzes the challenges intelligence faces in monitoring small, clandestine proliferation activities and the role it plays in supporting non-proliferation efforts. It then reviews the intelligence track record in monitoring proliferation including the lessons learned from Iraq. Finally, it addresses whether it is possible for intelligence to accurately monitor future clandestine proliferation efforts. (author)

  15. Quivers of Bound Path Algebras and Bound Path Coalgebras

    Directory of Open Access Journals (Sweden)

    Dr. Intan Muchtadi

    2010-09-01

    Full Text Available bras and coalgebras can be represented as quiver (directed graph, and from quiver we can construct algebras and coalgebras called path algebras and path coalgebras. In this paper we show that the quiver of a bound path coalgebra (resp. algebra is the dual quiver of its bound path algebra (resp. coalgebra.

  16. Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation.

    OpenAIRE

    Kubben, F J; Peeters-Haesevoets, A; Engels, L G; Baeten, C G; Schutte, B; Arends, J W; Stockbrügger, R W; Blijham, G H

    1994-01-01

    Immunohistochemistry of the S phase related proliferating cell nuclear antigen (PCNA) was studied as an alternative to ex-vivo bromodeoxyuridine (BrdU) immunohistochemistry for assessment of human colonic cell proliferation. From 16 subjects without colonic disease biopsy specimens were collected from five different sites along the colorectum and processed for BrdU and PCNA immunohistochemistry. The mean proliferation index of PCNA was significantly higher at 133% of the value obtained with B...

  17. Acquisition Path Analysis as a Collaborative Activity

    International Nuclear Information System (INIS)

    Nakao, A.; Grundule, R.; Gushchyn, K.; El Gebaly, A.; Higgy, R.; Tsvetkov, I.; Mandl, W.

    2015-01-01

    In the International Atomic Energy Agency, acquisition path analysis (APA) is indispensable to safeguards implementation. It is an integral part of both State evaluation process and the development of State level safeguards approaches, all performed through ongoing collaborative analysis of all available safeguards relevant information by State evaluation groups (SEG) with participation of other contributors, as required. To perform comprehensive State evaluation, to develop and revise State-level safeguards approaches, and to prepare annual implementation plans, the SEG in its collaborative analysis follows accepted safeguards methodology and guidance. In particular, the guide ''Performing Acquisition Path Analysis for the Development of a State-level Safeguards Approach for a State with a CSA'' is used. This guide identifies four major steps of the APA process: 1. Consolidating information about the State's past, present and planned nuclear fuel cycle-related capabilities and infrastructure; 2. Identifying and visually presenting technically plausible acquisition paths for the State; 3. Assessing acquisition path steps (State's technical capabilities and possible actions) along the identified acquisition paths; and 4. Assessing the time needed to accomplish each identified technically plausible acquisition path for the State. The paper reports on SEG members' and other contributors' experience with APA when following the above steps, including the identification of plausible acquisition pathways, estimation of time frames for all identified steps and determination of the time needed to accomplish each acquisition path. The difficulties that the SEG encountered during the process of performing the APA are also addressed. Feedback in the form of practical suggestions for improving the clarity of the acquisition path step assessment forms and a proposal for software support are also included. (author)

  18. Rheumatoid arthritis of the craniocervical region: assessment and characterization of inflammatory soft tissue proliferations with unenhanced and contrast-enhanced CT

    Energy Technology Data Exchange (ETDEWEB)

    Czerny, C.; Grampp, S.; Henk, C.B. [University Hospital Vienna (Austria). Dept. of Radiology; Neuhold, A. [Institute for Diagnostic Imaging, Hospital Rudolfinerhaus, Vienna (Austria); Stiskal, M. [Institute for Diagnostic Imaging, Hospital Lainz, Vienna (Austria); Smolen, J. [Department of Rheumatology, University Hospital Vienna (Austria)

    2000-09-01

    The aim of this study was to depict and characterize inflammatory soft tissue proliferations caused by rheumatoid arthritis (RA) in the craniocervical region by unenhanced and contrast-enhanced CT. Computed tomography of the craniocervical region was performed in 35 patients in the axial plane before and after the i. v. administration of contrast material. According to the densities and contrast enhancement of the inflammatory soft tissue proliferations, four groups were classified. Ancillary findings, such as a compression of the dural sac or spinal cord, erosions of the bony structures, and atlantoaxial subluxation, were also evaluated. Inflammatory soft tissue proliferations were depicted in 28 of 35 patients and could be differentiated by unenhanced and contrast-enhanced CT according to the above defined criteria: effusion in 6 patients (17 %); hypervascular pannus in 8 (23 %); hypovascular pannus in 5 (14 %); and fibrous tissue in 9 patients (26 %). A compression of the dural sac was seen in 11 (31 %) patients; 3 of these had neurological symptoms. Erosions of the odontoid process were found in 20 (57 %) patients; 16 (80 %) of these also showed erosions of the atlas. Atlantoaxial subluxation was seen in 11 (31 %) patients. Inflammatory soft tissue proliferations in the craniocervical region caused by RA can be reliably demonstrated and classified by unenhanced and contrast-enhanced CT, which can differentiate between joint effusion and various forms of pannus and depict ancillary findings. Computed tomography is an alternative method for patients unable to undergo an MRI examination. (orig.)

  19. Rheumatoid arthritis of the craniocervical region: assessment and characterization of inflammatory soft tissue proliferations with unenhanced and contrast-enhanced CT

    International Nuclear Information System (INIS)

    Czerny, C.; Grampp, S.; Henk, C.B.; Stiskal, M.; Smolen, J.

    2000-01-01

    The aim of this study was to depict and characterize inflammatory soft tissue proliferations caused by rheumatoid arthritis (RA) in the craniocervical region by unenhanced and contrast-enhanced CT. Computed tomography of the craniocervical region was performed in 35 patients in the axial plane before and after the i. v. administration of contrast material. According to the densities and contrast enhancement of the inflammatory soft tissue proliferations, four groups were classified. Ancillary findings, such as a compression of the dural sac or spinal cord, erosions of the bony structures, and atlantoaxial subluxation, were also evaluated. Inflammatory soft tissue proliferations were depicted in 28 of 35 patients and could be differentiated by unenhanced and contrast-enhanced CT according to the above defined criteria: effusion in 6 patients (17 %); hypervascular pannus in 8 (23 %); hypovascular pannus in 5 (14 %); and fibrous tissue in 9 patients (26 %). A compression of the dural sac was seen in 11 (31 %) patients; 3 of these had neurological symptoms. Erosions of the odontoid process were found in 20 (57 %) patients; 16 (80 %) of these also showed erosions of the atlas. Atlantoaxial subluxation was seen in 11 (31 %) patients. Inflammatory soft tissue proliferations in the craniocervical region caused by RA can be reliably demonstrated and classified by unenhanced and contrast-enhanced CT, which can differentiate between joint effusion and various forms of pannus and depict ancillary findings. Computed tomography is an alternative method for patients unable to undergo an MRI examination. (orig.)

  20. Paths correlation matrix.

    Science.gov (United States)

    Qian, Weixian; Zhou, Xiaojun; Lu, Yingcheng; Xu, Jiang

    2015-09-15

    Both the Jones and Mueller matrices encounter difficulties when physically modeling mixed materials or rough surfaces due to the complexity of light-matter interactions. To address these issues, we derived a matrix called the paths correlation matrix (PCM), which is a probabilistic mixture of Jones matrices of every light propagation path. Because PCM is related to actual light propagation paths, it is well suited for physical modeling. Experiments were performed, and the reflection PCM of a mixture of polypropylene and graphite was measured. The PCM of the mixed sample was accurately decomposed into pure polypropylene's single reflection, pure graphite's single reflection, and depolarization caused by multiple reflections, which is consistent with the theoretical derivation. Reflection parameters of rough surface can be calculated from PCM decomposition, and the results fit well with the theoretical calculations provided by the Fresnel equations. These theoretical and experimental analyses verify that PCM is an efficient way to physically model light-matter interactions.

  1. Leavitt path algebras

    CERN Document Server

    Abrams, Gene; Siles Molina, Mercedes

    2017-01-01

    This book offers a comprehensive introduction by three of the leading experts in the field, collecting fundamental results and open problems in a single volume. Since Leavitt path algebras were first defined in 2005, interest in these algebras has grown substantially, with ring theorists as well as researchers working in graph C*-algebras, group theory and symbolic dynamics attracted to the topic. Providing a historical perspective on the subject, the authors review existing arguments, establish new results, and outline the major themes and ring-theoretic concepts, such as the ideal structure, Z-grading and the close link between Leavitt path algebras and graph C*-algebras. The book also presents key lines of current research, including the Algebraic Kirchberg Phillips Question, various additional classification questions, and connections to noncommutative algebraic geometry. Leavitt Path Algebras will appeal to graduate students and researchers working in the field and related areas, such as C*-algebras and...

  2. Proliferation Vulnerability Red Team report

    Energy Technology Data Exchange (ETDEWEB)

    Hinton, J.P.; Barnard, R.W.; Bennett, D.E. [and others

    1996-10-01

    This report is the product of a four-month independent technical assessment of potential proliferation vulnerabilities associated with the plutonium disposition alternatives currently under review by DOE/MD. The scope of this MD-chartered/Sandia-led study was limited to technical considerations that could reduce proliferation resistance during various stages of the disposition processes below the Stored Weapon/Spent Fuel standards. Both overt and covert threats from host nation and unauthorized parties were considered. The results of this study will be integrated with complementary work by others into an overall Nonproliferation and Arms Control Assessment in support of a Secretarial Record of Decision later this year for disposition of surplus U.S. weapons plutonium.

  3. The Thinnest Path Problem

    Science.gov (United States)

    2016-07-22

    be reduced to TP in -D UDH for any . We then show that the 2-D disk hypergraph constructed in the proof of Theorem 1 can be modified to an exposed...transmission range that induces hy- peredge , i.e., (3) GAO et al.: THINNEST PATH PROBLEM 1181 Theorem 5 shows that the covered area of the path...representation of (the two hyperedges rooted at from the example given in Fig. 6 are illustrated in green and blue, respectively). step, we show in this

  4. Path dependence and creation

    DEFF Research Database (Denmark)

    Garud, Raghu; Karnøe, Peter

    This edited volume stems from a conference held in Copenhagen that the authors ran in August of 1997. The authors, aware of the recent work in evolutionary theory and the science of chaos and complexity, challenge the sometimes deterministic flavour of this work. They are interested in uncovering...... the place of agency in these theories that take history so seriously. In the end, they are as interested in path creation and destruction as they are in path dependence. This book is compiled of both theoretical and empirical writing. It shows relatively well-known industries such as the automobile...

  5. Reparametrization in the path integral

    International Nuclear Information System (INIS)

    Storchak, S.N.

    1983-01-01

    The question of the invariance of a measure in the n-dimensional path integral under the path reparametrization is considered. The non-invariance of the measure through the jacobian is suggeste. After the path integral reparametrization the representatioq for the Green's function of the Hamilton operator in terms of the path integral with the classical Hamiltonian has been obtained

  6. Director's series on proliferation

    International Nuclear Information System (INIS)

    Bailey, K.C.; Price, M.E.

    1995-01-01

    This is an occasional publication of essays on the topics of nuclear, chemical, biological, and missile proliferation. The views represented are those of the author's. Essay topics include: Nuclear Proliferation: Myth and Reality; Problems of Enforcing Compliance with Arms Control Agreements; The Unreliability of the Russian Officer Corps: Reluctant Domestic Warriors; and Russia's Nuclear Legacy

  7. Proliferation Networks and Financing

    International Nuclear Information System (INIS)

    Gruselle, Bruno

    2007-01-01

    The objective of this study is to propose practical solutions aimed at completing and strengthening the existing arrangement for the control of nuclear proliferation through a control of financial as well as material or immaterial flows. In a first part, the author proposes a systemic analysis of networks of suppliers and demanders. He notably evokes the Khan's network and the Iraqi acquisition network during the 1993-2001 period. He also proposes a modelling of proliferation networks (supplier networks and acquisition networks) and of their interactions. In a second part, the author examines possible means and policies aimed at neutralising proliferation networks: organisation, adaptation and improvement of intelligence tools in front of proliferation networks, and means, limitations and perspectives of network neutralisation. He also briefly addresses the possibility of military action to contain proliferation flows

  8. MEASURING PATH DEPENDENCY

    Directory of Open Access Journals (Sweden)

    Peter Juhasz

    2017-03-01

    Full Text Available While risk management gained popularity during the last decades even some of the basic risk types are still far out of focus. One of these is path dependency that refers to the uncertainty of how we reach a certain level of total performance over time. While decision makers are careful in accessing how their position will look like the end of certain periods, little attention is given how they will get there through the period. The uncertainty of how a process will develop across a shorter period of time is often “eliminated” by simply choosing a longer planning time interval, what makes path dependency is one of the most often overlooked business risk types. After reviewing the origin of the problem we propose and compare seven risk measures to access path. Traditional risk measures like standard deviation of sub period cash flows fail to capture this risk type. We conclude that in most cases considering the distribution of the expected cash flow effect caused by the path dependency may offer the best method, but we may need to use several measures at the same time to include all the optimisation limits of the given firm

  9. Proliferation resistance of small modular reactors fuels

    Energy Technology Data Exchange (ETDEWEB)

    Polidoro, F.; Parozzi, F. [RSE - Ricerca sul Sistema Energetico,Via Rubattino 54, 20134, Milano (Italy); Fassnacht, F.; Kuett, M.; Englert, M. [IANUS, Darmstadt University of Technology, Alexanderstr. 35, D-64283 Darmstadt (Germany)

    2013-07-01

    In this paper the proliferation resistance of different types of Small Modular Reactors (SMRs) has been examined and classified with criteria available in the literature. In the first part of the study, the level of proliferation attractiveness of traditional low-enriched UO{sub 2} and MOX fuels to be used in SMRs based on pressurized water technology has been analyzed. On the basis of numerical simulations both cores show significant proliferation risks. Although the MOX core is less proliferation prone in comparison to the UO{sub 2} core, it still can be highly attractive for diversion or undeclared production of nuclear material. In the second part of the paper, calculations to assess the proliferation attractiveness of fuel in typical small sodium cooled fast reactor show that proliferation risks from spent fuel cannot be neglected. The core contains a highly attractive plutonium composition during the whole life cycle. Despite some aspects of the design like the sealed core that enables easy detection of unauthorized withdrawal of fissile material and enhances proliferation resistance, in case of open Non-Proliferation Treaty break-out, weapon-grade plutonium in sufficient quantities could be extracted from the reactor core.

  10. Non-proliferation

    International Nuclear Information System (INIS)

    Manley, I.T.

    1981-01-01

    Proliferation is a problem that can only be solved when the political problems which lead countries to contemplate, the possession of nuclear weapons are solved; in the meantime it can only be managed. Non-proliferation policy has to deal both with the political and the technical aspects of proliferation. It must seek to buy time by addressing the reasons why nations feel the political need to construct nuclear weapons, as well as delaying the moment when such nations feel capable of doing so. The subject is examined and proposals made. (author)

  11. Getting serious about proliferation

    International Nuclear Information System (INIS)

    Leventhal, P.

    1984-01-01

    The US needs to give a higher priority to nuclear non-proliferation, but Reagan's policies assume that proliferation is inevitable and that it is more important to be a reliable supplier than to cause trade frictions by trading only with those nations which sign the non-proliferation treaty (NPT). This undercuts US leadership and the intent of the agreement. Several bills now before Congress could help to restore US leadership by tightening export restrictions and the use of plutonium from the US

  12. Nonadiabatic transition path sampling

    International Nuclear Information System (INIS)

    Sherman, M. C.; Corcelli, S. A.

    2016-01-01

    Fewest-switches surface hopping (FSSH) is combined with transition path sampling (TPS) to produce a new method called nonadiabatic path sampling (NAPS). The NAPS method is validated on a model electron transfer system coupled to a Langevin bath. Numerically exact rate constants are computed using the reactive flux (RF) method over a broad range of solvent frictions that span from the energy diffusion (low friction) regime to the spatial diffusion (high friction) regime. The NAPS method is shown to quantitatively reproduce the RF benchmark rate constants over the full range of solvent friction. Integrating FSSH within the TPS framework expands the applicability of both approaches and creates a new method that will be helpful in determining detailed mechanisms for nonadiabatic reactions in the condensed-phase.

  13. Nuclear proliferation and terrorism

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    This section of the book, Part III, has two chapters (9 and 10). Chapter 9, Nuclear Power and Proliferation of Nuclear Weapons, is disucssed under these subjects: nuclear nonproliferation: origins and status; requirements for nuclear weapons manufacture; current nuclear programs and proliferation capabilities; encouraging decisions to forego weapons; arms control; safeguards; attitudes and expectations. Chapter 10, Nuclear Terrorism, discusses these areas: theft of nuclear materials; attacks on nuclear reactors; responding to nuclear terrorism; security and civil liberties

  14. Shortest Paths and Vehicle Routing

    DEFF Research Database (Denmark)

    Petersen, Bjørn

    This thesis presents how to parallelize a shortest path labeling algorithm. It is shown how to handle Chvátal-Gomory rank-1 cuts in a column generation context. A Branch-and-Cut algorithm is given for the Elementary Shortest Paths Problem with Capacity Constraint. A reformulation of the Vehicle...... Routing Problem based on partial paths is presented. Finally, a practical application of finding shortest paths in the telecommunication industry is shown....

  15. Framework of Comprehensive Proliferation Resistance Evaluation Methodology

    International Nuclear Information System (INIS)

    Kim, Min Su; Jo, Seong Youn; Kim, Min Soo; Kim, Jae San; Lee, Hyun Kyung

    2007-01-01

    Civilian nuclear programs can be used as a pretext to acquire technologies, materials, equipment for military weapon programs. Consequently, international society has a strong incentive to develop a nuclear system more proliferation resistant to assure that the civilian nuclear energy system is an unattractive and least desirable route for diversion of weapon usable material. The First step developing a more proliferation resistant nuclear energy system is to develop a systematic and standardized evaluation methodology to ensure that any future nuclear energy system satisfies the proliferation resistance goals. Many attempts to develop systematic evaluation methodology have been proposed and many systems for assessing proliferation resistance have been previously studied. However, a comprehensive proliferation resistance evaluation can not be achieved by simply applying one method since complicated proliferation resistance characteristics, including inherent features and extrinsic features, should be completely evaluated. Therefore, it is necessary to develop one incorporated evaluation methodology to make up for weak points of each evaluation method. The objective of this study is to provide a framework of comprehensive proliferation resistance evaluation methodology by incorporating two generally used evaluation methods, attribute and scenario analysis

  16. Guidance for the application of an assessment methodology for innovative nuclear energy systems. INPRO manual - Proliferation resistance. Vol. 5 of the final report of phase 1 of the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO)

    International Nuclear Information System (INIS)

    2008-11-01

    The International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) was initiated in the year 2000, based on a resolution of the IAEA General Conference (GC(44)/RES/21). The main objectives of INPRO are (1) to help to ensure that nuclear energy is available to contribute in fulfilling energy needs in the 21st century in a sustainable manner, (2) to bring together both technology holders and technology users to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles; and (3) to create a forum to involve all relevant stakeholders that will have an impact on, draw from, and complement the activities of existing institutions, as well as ongoing initiatives at the national and international level. The INPRO manual is comprised of an overview volume (No. 1), and eight additional volumes covering the areas of economics (Volume 2), infrastructure (Volume 3), waste management (Volume 4), proliferation resistance (laid out in this report) (Volume 5), physical protection (Volume 6), environment (Volume 7), safety of nuclear reactors (Volume 8), and safety of nuclear fuel cycle facilities (Volume 9). This volume of the INPRO manual is based on the results of an INPRO study on proliferation resistance of the DUPIC fuel cycle performed by the Republic of Korea during 2005 and 2006, recommendations from IAEA consultancy meetings, and on a special service agreement with G. Pshakin (Russian Federation). The INPRO Manual starts with an introduction in Chapter 1. In Chapter 2, the necessary information is described to perform an INPRO assessment in the area of proliferation resistance. Explanatory notes on the INPRO basic principles (BP) and user requirements (UR) in the area of proliferation resistance, are reproduced in Chapter 3 to provide context for the assessor; additionally, background of each criterion (CR) and a corresponding procedure is described how to perform an INPRO assessment. The

  17. Does the component processes task assess text-based inferences important for reading comprehension? A path analysis in primary school children

    NARCIS (Netherlands)

    S.I. Wassenburg (Stephanie); B.B. de Koning (Björn); de Vries, M.H. (Meinou H.); M. van der Schoot (Menno)

    2016-01-01

    textabstractUsing a component processes task (CPT) that differentiates between higher-level cognitive processes of reading comprehension provides important advantages over commonly used general reading comprehension assessments. The present study contributes to further development of the CPT by

  18. Does the component processes task assess text-based inferences important for reading comprehension? A path analysis in primary school children

    NARCIS (Netherlands)

    Wassenburg, Stephanie I.; de Koning, Björn B.; de Vries, Meinou H.; van der Schoot, Menno

    2016-01-01

    Using a component processes task (CPT) that differentiates between higher-level cognitive processes of reading comprehension provides important advantages over commonly used general reading comprehension assessments. The present study contributes to further development of the CPT by evaluating the

  19. Rocket Flight Path

    Directory of Open Access Journals (Sweden)

    Jamie Waters

    2014-09-01

    Full Text Available This project uses Newton’s Second Law of Motion, Euler’s method, basic physics, and basic calculus to model the flight path of a rocket. From this, one can find the height and velocity at any point from launch to the maximum altitude, or apogee. This can then be compared to the actual values to see if the method of estimation is a plausible. The rocket used for this project is modeled after Bullistic-1 which was launched by the Society of Aeronautics and Rocketry at the University of South Florida.

  20. JAVA PathFinder

    Science.gov (United States)

    Mehhtz, Peter

    2005-01-01

    JPF is an explicit state software model checker for Java bytecode. Today, JPF is a swiss army knife for all sort of runtime based verification purposes. This basically means JPF is a Java virtual machine that executes your program not just once (like a normal VM), but theoretically in all possible ways, checking for property violations like deadlocks or unhandled exceptions along all potential execution paths. If it finds an error, JPF reports the whole execution that leads to it. Unlike a normal debugger, JPF keeps track of every step how it got to the defect.

  1. Hamiltonian path integrals

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1982-01-01

    Problems related to consideration of operator nonpermutability in Hamiltonian path integral (HPI) are considered in the review. Integrals are investigated using trajectories in configuration space (nonrelativistic quantum mechanics). Problems related to trajectory integrals in HPI phase space are discussed: the problem of operator nonpermutability consideration (extra terms problem) and corresponding equivalence rules; ambiguity of HPI usual recording; transition to curvilinear coordinates. Problem of quantization of dynamical systems with couplings has been studied. As in the case of canonical transformations, quantization of the systems with couplings of the first kind requires the consideration of extra terms

  2. Path to Prosperity

    OpenAIRE

    Wolfowitz,Paul

    2006-01-01

    Paul Wolfowitz, President of the World Bank, discussed Singapore's remarkable progress along the road from poverty to prosperity which has also been discovered by many other countries in East Asia and around the world. He spoke of how each country must find its own path for people to pursue the same dreams of the chance to go to school, the security of a good job, and the ability to provide a better future for their children. Throughout the world, and importantly in the developing world, ther...

  3. Nuclear non-proliferation

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    DOE's nuclear non-proliferation responsibilities are defined by the provisions of the Atomic Energy Act of 1954, as amended, and of the Nuclear Non-Proliferation Act of 1978 (NNPA). The Department's major responsibilities in this area are to: (1) provide technical assistance to the Department of State in negotiating agreements for civil cooperation in the peaceful uses of nuclear energy with other countries and international organizations; (2) join with other agencies to reach executive branch judgments with respect to the issuance of export licenses by the Nuclear Regulatory Commission; (3) be responsible for processing subsequent arrangements with other agencies as required by the Nuclear Non-Proliferation Act; (4) control the distribution of special nuclear materials, components, equipment, and nuclear technology exports; (5) participate in bilateral and multilateral cooperation with foreign governments and organizations to promote the peaceful uses of nuclear energy; and (6) act as a primary technical resource with respect to US participation in the International Atomic Energy Agency

  4. Dynamics of nuclear proliferation

    International Nuclear Information System (INIS)

    Meyer, S.M.

    1984-01-01

    This book looks beyond policy disputes to make a systematic examination of the assumptions and contending hypotheses that constitute contemporary thinking on nuclear proliferation. Rather than determine who is right or wrong, the intent is to develop a better picture by using the various schools of thought as analytic windows. A better understanding of how the process operates should offer better guidance for predicting future nuclear proliferation and, ultimately, for controlling it. Separate chapters deal with the contending views, the technological and motivational bases of nuclear proliferation, the presence of a technological imperative, testing the motivational hypothesis, the dynamics of the process, and forecasting. Four appendices present historical decisions, the technical model, cost-estimating procedures, and procedures for estimating nuclear propensities. 288 references, 17 figures, 26 tables

  5. MinePath: Mining for Phenotype Differential Sub-paths in Molecular Pathways

    Science.gov (United States)

    Koumakis, Lefteris; Kartsaki, Evgenia; Chatzimina, Maria; Zervakis, Michalis; Vassou, Despoina; Marias, Kostas; Moustakis, Vassilis; Potamias, George

    2016-01-01

    Pathway analysis methodologies couple traditional gene expression analysis with knowledge encoded in established molecular pathway networks, offering a promising approach towards the biological interpretation of phenotype differentiating genes. Early pathway analysis methodologies, named as gene set analysis (GSA), view pathways just as plain lists of genes without taking into account either the underlying pathway network topology or the involved gene regulatory relations. These approaches, even if they achieve computational efficiency and simplicity, consider pathways that involve the same genes as equivalent in terms of their gene enrichment characteristics. Most recent pathway analysis approaches take into account the underlying gene regulatory relations by examining their consistency with gene expression profiles and computing a score for each profile. Even with this approach, assessing and scoring single-relations limits the ability to reveal key gene regulation mechanisms hidden in longer pathway sub-paths. We introduce MinePath, a pathway analysis methodology that addresses and overcomes the aforementioned problems. MinePath facilitates the decomposition of pathways into their constituent sub-paths. Decomposition leads to the transformation of single-relations to complex regulation sub-paths. Regulation sub-paths are then matched with gene expression sample profiles in order to evaluate their functional status and to assess phenotype differential power. Assessment of differential power supports the identification of the most discriminant profiles. In addition, MinePath assess the significance of the pathways as a whole, ranking them by their p-values. Comparison results with state-of-the-art pathway analysis systems are indicative for the soundness and reliability of the MinePath approach. In contrast with many pathway analysis tools, MinePath is a web-based system (www.minepath.org) offering dynamic and rich pathway visualization functionality, with the

  6. Cell Proliferation in Neuroblastoma

    Science.gov (United States)

    Stafman, Laura L.; Beierle, Elizabeth A.

    2016-01-01

    Neuroblastoma, the most common extracranial solid tumor of childhood, continues to carry a dismal prognosis for children diagnosed with advanced stage or relapsed disease. This review focuses upon factors responsible for cell proliferation in neuroblastoma including transcription factors, kinases, and regulators of the cell cycle. Novel therapeutic strategies directed toward these targets in neuroblastoma are discussed. PMID:26771642

  7. Controlling nuclear proliferation

    International Nuclear Information System (INIS)

    Sweet, W.

    1981-01-01

    Nuclear non-proliferation policy depends on the 1968 Non-Proliferation Treaty, in which countries promise not to acquire nuclear weapons in exchange for open access to peaceful nuclear technology, and a system of international safeguards that are imposed on exported nuclear equipment and facilities operated by parties to the treaty. Critics have feared all along that non-nuclear countries might circumvent or exploit the system to obtain nuclear weapons and that the Atoms for Peace plan would spread the very technology it sought to control. The nuclear weapons states would like everyone else to believe that atomic bombs are undesirable, but they continue to rely on the bombs for their own defense. Israel's raid on Iraq's nuclear reactor focused world attention on the proliferation problem and helped to broaden and sterengthen its prospects. It also highlighted the weakness that there are no effective sanctions against violators. Until the international community can ageee on enforcement measures powerful enough to prevent nuclear proliferation, individual countries may be tempted to follow Israel's example, 19 references

  8. Paths of Cultural Systems

    Directory of Open Access Journals (Sweden)

    Paul Ballonoff

    2017-12-01

    Full Text Available A theory of cultural structures predicts the objects observed by anthropologists. We here define those which use kinship relationships to define systems. A finite structure we call a partially defined quasigroup (or pdq, as stated by Definition 1 below on a dictionary (called a natural language allows prediction of certain anthropological descriptions, using homomorphisms of pdqs onto finite groups. A viable history (defined using pdqs states how an individual in a population following such history may perform culturally allowed associations, which allows a viable history to continue to survive. The vector states on sets of viable histories identify demographic observables on descent sequences. Paths of vector states on sets of viable histories may determine which histories can exist empirically.

  9. Propagators and path integrals

    Energy Technology Data Exchange (ETDEWEB)

    Holten, J.W. van

    1995-08-22

    Path-integral expressions for one-particle propagators in scalar and fermionic field theories are derived, for arbitrary mass. This establishes a direct connection between field theory and specific classical point-particle models. The role of world-line reparametrization invariance of the classical action and the implementation of the corresponding BRST-symmetry in the quantum theory are discussed. The presence of classical world-line supersymmetry is shown to lead to an unwanted doubling of states for massive spin-1/2 particles. The origin of this phenomenon is traced to a `hidden` topological fermionic excitation. A different formulation of the pseudo-classical mechanics using a bosonic representation of {gamma}{sub 5} is shown to remove these extra states at the expense of losing manifest supersymmetry. (orig.).

  10. innovation path exploration

    Directory of Open Access Journals (Sweden)

    Li Jian

    2016-01-01

    Full Text Available The world has entered the information age, all kinds of information technologies such as cloud technology, big data technology are in rapid development, and the “Internet plus” appeared. The main purpose of “Internet plus” is to provide an opportunity for the further development of the enterprise, the enterprise technology, business and other aspects of factors combine. For enterprises, grasp the “Internet plus” the impact of the market economy will undoubtedly pave the way for the future development of enterprises. This paper will be on the innovation path of the enterprise management “Internet plus” era tied you study, hope to be able to put forward some opinions and suggestions.

  11. Supporting non proliferation and global security efforts

    International Nuclear Information System (INIS)

    Pochon, E.

    2013-01-01

    CEA contributes as a major actor of France's action against nuclear proliferation and to the strengthening of nuclear security at national level as European and International levels, in particular through the support of the IAEA activities in nuclear non proliferation with the French Support Programme for the IAEA safeguards system and security with the contribution to the IAEA Nuclear Security Plan and cooperation projects with the European Commission. The CEA is a French government funded technological research organization, organized around 5 branches: Nuclear Energy, Technological Researches, Defence (DAM), Material Sciences and Life Sciences. Within the scope of its activities, CEA covers most of the research areas and techniques in nuclear non-proliferation and security. The CEA is also the advisor of the French Government on nuclear policy. Treaty monitoring and the development and implementation of non proliferation and global security programs is an important mission of DAM which rely on nuclear weapons manufacture and past testing experience. The programmes on non proliferation and global security carried out to fulfil DAM's mission cover the following areas: development of monitoring and detection methods and equipments, country profiles and nuclear stockpiles assessment, arms control instruments, proliferation resistance of nuclear fuel cycle, monitoring of nuclear tests, operation and maintenance of national detection capabilities and contribution to CTBT verification systems. (A.C.)

  12. A management-oriented framework for selecting metrics used to assess habitat- and path-specific quality in spatially structured populations

    Science.gov (United States)

    Nicol, Sam; Wiederholt, Ruscena; Diffendorfer, James E.; Mattsson, Brady; Thogmartin, Wayne E.; Semmens, Darius J.; Laura Lopez-Hoffman,; Norris, Ryan

    2016-01-01

    Mobile species with complex spatial dynamics can be difficult to manage because their population distributions vary across space and time, and because the consequences of managing particular habitats are uncertain when evaluated at the level of the entire population. Metrics to assess the importance of habitats and pathways connecting habitats in a network are necessary to guide a variety of management decisions. Given the many metrics developed for spatially structured models, it can be challenging to select the most appropriate one for a particular decision. To guide the management of spatially structured populations, we define three classes of metrics describing habitat and pathway quality based on their data requirements (graph-based, occupancy-based, and demographic-based metrics) and synopsize the ecological literature relating to these classes. Applying the first steps of a formal decision-making approach (problem framing, objectives, and management actions), we assess the utility of metrics for particular types of management decisions. Our framework can help managers with problem framing, choosing metrics of habitat and pathway quality, and to elucidate the data needs for a particular metric. Our goal is to help managers to narrow the range of suitable metrics for a management project, and aid in decision-making to make the best use of limited resources.

  13. Path integral in Snyder space

    Energy Technology Data Exchange (ETDEWEB)

    Mignemi, S., E-mail: smignemi@unica.it [Dipartimento di Matematica e Informatica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); INFN, Sezione di Cagliari, Cittadella Universitaria, 09042 Monserrato (Italy); Štrajn, R. [Dipartimento di Matematica e Informatica, Università di Cagliari, Viale Merello 92, 09123 Cagliari (Italy); INFN, Sezione di Cagliari, Cittadella Universitaria, 09042 Monserrato (Italy)

    2016-04-29

    The definition of path integrals in one- and two-dimensional Snyder space is discussed in detail both in the traditional setting and in the first-order formalism of Faddeev and Jackiw. - Highlights: • The definition of the path integral in Snyder space is discussed using phase space methods. • The same result is obtained in the first-order formalism of Faddeev and Jackiw. • The path integral formulation of the two-dimensional Snyder harmonic oscillator is outlined.

  14. Path integral in Snyder space

    International Nuclear Information System (INIS)

    Mignemi, S.; Štrajn, R.

    2016-01-01

    The definition of path integrals in one- and two-dimensional Snyder space is discussed in detail both in the traditional setting and in the first-order formalism of Faddeev and Jackiw. - Highlights: • The definition of the path integral in Snyder space is discussed using phase space methods. • The same result is obtained in the first-order formalism of Faddeev and Jackiw. • The path integral formulation of the two-dimensional Snyder harmonic oscillator is outlined.

  15. Nuclear non-proliferation

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    This patent describes the treaty on the non-proliferation of nuclear weapons which is the corner-stone of an international non-proliferation regime which has grown to embrace the overwhelming majority of countries in the world in the period since the Treaty. The other elements of the regime include, first of all, the safeguards system of IAEA-which operates to prevent the diversion of nuclear materials to military or other prohibited activities and must be accepted by all non-nuclear-weapon parties to the Treaty and, secondly, the Antarctic Treaty, the Treaty for the Prohibition of Nuclear Weapons in Latin America (Treaty of Tlatelolco) and the south Pacific Nuclear Free zone Treaty (Treaty of Rarotonga)-which serve to extend the regime geographically. The last two Treaties require safeguards agreements with IAEA. In addition, the Treaty of Tlatelolco contains provisions establishing the agency for the Prohibition of Nuclear Weapons in Latin America and the Caribbean to ensure compliance

  16. Proliferation in cycle

    Energy Technology Data Exchange (ETDEWEB)

    Piao Yunsong [College of Physical Sciences, Graduate School of Chinese Academy of Sciences, Beijing 100049 (China)], E-mail: yspiao@gucas.ac.cn

    2009-06-15

    In the contracting phase with w{approx_equal}0, the scale invariant spectrum of curvature perturbation is given by the increasing mode of metric perturbation. In this Letter, it is found that if the contracting phase with w{approx_equal}0 is included in each cycle of a cycle universe, since the metric perturbation is amplified on super horizon scale cycle by cycle, after each cycle the universe will be inevitably separated into many parts independent of one another, each of which corresponds to a new universe and evolves up to next cycle, and then is separated again. In this sense, a cyclic multiverse scenario is actually presented, in which the universe proliferates cycle by cycle. We estimate the number of new universes proliferated in each cycle, and discuss the implications of this result.

  17. Proliferation in cycle

    International Nuclear Information System (INIS)

    Piao Yunsong

    2009-01-01

    In the contracting phase with w≅0, the scale invariant spectrum of curvature perturbation is given by the increasing mode of metric perturbation. In this Letter, it is found that if the contracting phase with w≅0 is included in each cycle of a cycle universe, since the metric perturbation is amplified on super horizon scale cycle by cycle, after each cycle the universe will be inevitably separated into many parts independent of one another, each of which corresponds to a new universe and evolves up to next cycle, and then is separated again. In this sense, a cyclic multiverse scenario is actually presented, in which the universe proliferates cycle by cycle. We estimate the number of new universes proliferated in each cycle, and discuss the implications of this result.

  18. Quantifying Detection Probabilities for Proliferation Activities in Undeclared Facilities

    International Nuclear Information System (INIS)

    Listner, C.; Canty, M.; Niemeyer, I.; Rezniczek, A.; Stein, G.

    2015-01-01

    International Safeguards is currently in an evolutionary process to increase effectiveness and efficiency of the verification system. This is an obvious consequence of the inability to detect the Iraq's clandestine nuclear weapons programme in the early 90s. By the adoption of the Programme 93+2, this has led to the development of Integrated Safeguards and the State-level concept. Moreover, the IAEA's focus was extended onto proliferation activities outside the State's declared facilities. The effectiveness of safeguards activities within declared facilities can and have been quantified with respect to costs and detection probabilities. In contrast, when verifying the absence of undeclared facilities this quantification has been avoided in the past because it has been considered to be impossible. However, when balancing the allocation of budget between the declared and the undeclared field, explicit reasoning is needed why safeguards effort is distributed in a given way. Such reasoning can be given by a holistic, information and risk-driven approach to Acquisition Path Analysis comprising declared and undeclared facilities. Regarding the input, this approach relies on the quantification of several factors, i.e., costs of attractiveness values for specific proliferation activities, potential safeguards measures and detection probabilities for these measures also for the undeclared field. In order to overcome the lack of quantification for detection probabilities in undeclared facilities, the authors of this paper propose a general verification error model. Based on this model, four different approaches are explained and assessed with respect to their advantages and disadvantages: the analogy approach, the Bayes approach, the frequentist approach and the process approach. The paper concludes with a summary and an outlook on potential future research activities. (author)

  19. Global proliferation concerns

    International Nuclear Information System (INIS)

    Simpkins, R.

    1978-01-01

    The Non-Proliferation Treaty and the IAGA Safeguards System are discussed. President Carter's program to defer commercial reprocessing and recycle, to restructure the breeder program, to develop alternative fuel cycles, to increase US uranium enrichment capability, to provide fuel assurance for consumer nations, to continue the embargo of sensitive technology and equipment and to develop the International Nuclear Fuel Cycle Evaluation Program is outlined

  20. Economic assessment of smart grids solutions. Analysis carried out by the distribution network operators. Executive Summary 2017. The new paths of electricity

    International Nuclear Information System (INIS)

    2017-05-01

    The economic viability of the Smart grids solutions is a key concern. This was highlighted in a letter from the ministries for the Environment, Sustainable Development and Energy and for the Economy, Industry and Digital Technology, which requested additional information regarding this question with regard to the distribution and transmission networks. Enedis and ADEeF (Association gathering electricity distributors in France), have realized a study on the economic assessment of smart grids solutions, in order to analyze associated costs and benefits. This study is part of a global approach conducted by the Ministries and in collaboration with ADEME and RTE. The functions featured in this study concern the transmission substation and MV network: Operational planning system, Extension of self-healing capabilities of the distribution network, Centralised dynamic voltage control, Self-adaptive reactive power control by MV producers, Active power curtailment of MV production, Use of flexibility for demand constraints. The results presented in this study are coherent with actual investment decisions and foreshadow future action plans

  1. Joint Community Health Needs Assessments as a Path for Coordinating Community-Wide Health Improvement Efforts Between Hospitals and Local Health Departments.

    Science.gov (United States)

    Carlton, Erik L; Singh, Simone Rauscher

    2018-05-01

    To examine the association between hospital-local health department (LHD) collaboration around community health needs assessments (CHNAs) and hospital investment in community health. We combined 2015 National Association of County and City Health Officials (NACCHO) Forces of Change, 2013 NACCHO Profile, and 2014-2015 Area Health Resource File data to identify a sample of LHDs (n = 439) across the United States. We included data on hospitals' community benefit from their 2014 tax filings (Internal Revenue Service Form 990, Schedule H). We used bivariate and multivariate regression analyses to examine LHDs' involvement in hospitals' CHNAs and implementation strategies and the relationship with hospital investment in community health. The LHDs that collaborated with hospitals around CHNAs were significantly more likely to be involved in joint implementation planning activities than were those that did not. Importantly, LHD involvement in hospitals' implementation strategies was associated with greater hospital investment in community health improvement initiatives. Joint CHNAs may improve coordination of community-wide health improvement efforts between hospitals and LHDs and encourage hospital investment in community health improvement activities. Public Health Implications. Policies that strengthen LHD-hospital collaboration around the CHNA may enhance hospital investments in community health.

  2. Practicality of diversion path analysis

    International Nuclear Information System (INIS)

    Murphey, W.M.; Schleter, J.C.

    1974-07-01

    One can define the safeguards system for nuclear material as the set of all protective actions taken to prevent or to deter attempts to divert nuclear material to unauthorized use. Maintenance of effective safeguards requires a program for routine assessment of plant safeguards systems in terms of their capabilities to satisfy safeguards aims. Plant internal control systems provide capabilities for detection of unprevented diversion and can provide assurance that diversion has not occurred. A procedure called Diversion Path Analysis (DPA) enables routine assessment of the capabilities of internal control systems in this regard and identification of safeguards problem areas in a plant. A framework for safeguards system design is also provided which will allow flexibility to accommodate individual plant circumstances while maintaining acceptable diversion detection capability. The steps of the procedure are described and the practicality of the analytical method is shown by referring to a demonstration test for a high throughput process where plant personnel were major participants. The boundary conditions for the demonstration case are given, along with some conclusions about the general procedure. (U.S.)

  3. Field determination of biomass burning emission ratios and factors via open-path FTIR spectroscopy and fire radiative power assessment: headfire, backfire and residual smouldering combustion in African savannahs

    Directory of Open Access Journals (Sweden)

    M. J. Wooster

    2011-11-01

    Full Text Available Biomass burning emissions factors are vital to quantifying trace gas release from vegetation fires. Here we evaluate emissions factors for a series of savannah fires in Kruger National Park (KNP, South Africa using ground-based open path Fourier transform infrared (FTIR spectroscopy and an IR source separated by 150–250 m distance. Molecular abundances along the extended open path are retrieved using a spectral forward model coupled to a non-linear least squares fitting approach. We demonstrate derivation of trace gas column amounts for horizontal paths transecting the width of the advected plume, and find for example that CO mixing ratio changes of ~0.01 μmol mol−1 [10 ppbv] can be detected across the relatively long optical paths used here. Though FTIR spectroscopy can detect dozens of different chemical species present in vegetation fire smoke, we focus our analysis on five key combustion products released preferentially during the pyrolysis (CH2O, flaming (CO2 and smoldering (CO, CH4, NH3 processes. We demonstrate that well constrained emissions ratios for these gases to both CO2 and CO can be derived for the backfire, headfire and residual smouldering combustion (RSC stages of these savannah fires, from which stage-specific emission factors can then be calculated. Headfires and backfires often show similar emission ratios and emission factors, but those of the RSC stage can differ substantially. The timing of each fire stage was identified via airborne optical and thermal IR imagery and ground-observer reports, with the airborne IR imagery also used to derive estimates of fire radiative energy (FRE, allowing the relative amount of fuel burned in each stage to be calculated and "fire averaged" emission ratios and emission factors to be determined. These "fire averaged" metrics are dominated by the headfire contribution, since the FRE data indicate that the vast majority

  4. Proliferation after the Iraq war

    International Nuclear Information System (INIS)

    Daguzan, J.F.

    2004-09-01

    This article uses the Iraq war major event to analyze the approach used by the US to fight against proliferation. It questions the decision and analysis process which has led to the US-British intervention and analyzes the consequences of the war on the proliferation of other countries and on the expected perspectives. Finally, the future of proliferation itself is questioned: do we have to fear more threat or is the virtuous circle of non-proliferation well started? (J.S.)

  5. Non-proliferation and nuclear disarmament

    International Nuclear Information System (INIS)

    Shea, M.

    2000-01-01

    Fissionable materials are common to all nuclear weapons and controls on the production, storage, processing and use of fissionable materials provides one means to address non-proliferation and disarmament. In this article, the relevance of such controls is examined and the current situation and future prospects are assessed. (authors)

  6. Luteoloside Inhibits Proliferation of Human Chronic Myeloid ...

    African Journals Online (AJOL)

    Purpose: To investigate the effects of luteoloside on the proliferation of human chronic myeloid leukemia K562 cells and whether luteoloside induces cell cycle arrest and apoptosis in K562 cells. Methods: Luteoloside's cytotoxicity was assessed using a cell counting kit. Cell cycle distribution was analysed by flow cytometry ...

  7. Two Generations of Path Dependence

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

      Even if there is no fully articulated and generally accepted theory of Path Dependence it has eagerly been taken up across a wide range of social sciences - primarily coming from economics. Path Dependence is most of all a metaphor that offers reason to believe, that some political, social...

  8. Chromatic roots and hamiltonian paths

    DEFF Research Database (Denmark)

    Thomassen, Carsten

    2000-01-01

    We present a new connection between colorings and hamiltonian paths: If the chromatic polynomial of a graph has a noninteger root less than or equal to t(n) = 2/3 + 1/3 (3)root (26 + 6 root (33)) + 1/3 (3)root (26 - 6 root (33)) = 1.29559.... then the graph has no hamiltonian path. This result...

  9. On Hilbert space of paths

    International Nuclear Information System (INIS)

    Exner, P.; Kolerov, G.I.

    1980-01-01

    A Hilbert space of paths, the elements of which are determined by trigonometric series, was proposed and used recently by Truman. This space is shown to consist precisely of all absolutely continuous paths ending in the origin with square-integrable derivatives

  10. Proliferation Persuasion. Coercive Bargaining with Nuclear Technology

    Energy Technology Data Exchange (ETDEWEB)

    Volpe, Tristan A. [George Washington Univ., Washington, DC (United States)

    2015-08-31

    Why do states wait for prolonged periods of time with the technical capacity to produce nuclear weapons? Only a handful of countries have ever acquired the sensitive nuclear fuel cycle technology needed to produce fissile material for nuclear weapons. Yet the enduring trend over the last five decades is for these states to delay or forgo exercising the nuclear weapons option provided by uranium enrichment or plutonium reprocessing capabilities. I show that states pause at this threshold stage because they use nuclear technology to bargain for concessions from both allies and adversaries. But when does nuclear latency offer bargaining benefits? My central argument is that challengers must surmount a dilemma to make coercive diplomacy work: the more they threaten to proliferate, the harder it becomes to reassure others that compliance will be rewarded with nuclear restraint. I identify a range of mechanisms able to solve this credibility problem, from arms control over breakout capacity to third party mediation and confidence building measures. Since each step towards the bomb raises the costs of implementing these policies, a state hits a sweet spot when it first acquires enrichment and/or reprocessing (ENR) technology. Subsequent increases in proliferation capability generate diminishing returns at the bargaining table for two reasons: the state must go to greater lengths to make a credible nonproliferation promise, and nuclear programs exhibit considerable path dependency as they mature over time. Contrary to the conventional wisdom about power in world politics, less nuclear latency thereby yields more coercive threat advantages. I marshal new primary source evidence from archives and interviews to identify episodes in the historical record when states made clear decisions to use ENR technology as a bargaining chip, and employ this theory of proliferation persuasion to explain how Japan, North Korea, and Iran succeeded and failed to barter concessions from the

  11. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle description

    International Nuclear Information System (INIS)

    1980-06-01

    The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates

  12. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle description

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    The Nonproliferation Alterntive Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates.

  13. Hard paths, soft paths or no paths? Cross-cultural perceptions of water solutions

    Science.gov (United States)

    Wutich, A.; White, A. C.; White, D. D.; Larson, K. L.; Brewis, A.; Roberts, C.

    2014-01-01

    In this study, we examine how development status and water scarcity shape people's perceptions of "hard path" and "soft path" water solutions. Based on ethnographic research conducted in four semi-rural/peri-urban sites (in Bolivia, Fiji, New Zealand, and the US), we use content analysis to conduct statistical and thematic comparisons of interview data. Our results indicate clear differences associated with development status and, to a lesser extent, water scarcity. People in the two less developed sites were more likely to suggest hard path solutions, less likely to suggest soft path solutions, and more likely to see no path to solutions than people in the more developed sites. Thematically, people in the two less developed sites envisioned solutions that involve small-scale water infrastructure and decentralized, community-based solutions, while people in the more developed sites envisioned solutions that involve large-scale infrastructure and centralized, regulatory water solutions. People in the two water-scarce sites were less likely to suggest soft path solutions and more likely to see no path to solutions (but no more likely to suggest hard path solutions) than people in the water-rich sites. Thematically, people in the two water-rich sites seemed to perceive a wider array of unrealized potential soft path solutions than those in the water-scarce sites. On balance, our findings are encouraging in that they indicate that people are receptive to soft path solutions in a range of sites, even those with limited financial or water resources. Our research points to the need for more studies that investigate the social feasibility of soft path water solutions, particularly in sites with significant financial and natural resource constraints.

  14. Proliferation resistance criteria for fissile material disposition

    International Nuclear Information System (INIS)

    Close, D.A.; Fearey, B.L.; Markin, J.T.; Rutherford, D.A.; Duggan, R.A.; Jaeger, C.D.; Mangan, D.L.; Moya, R.W.; Moore, L.R.; Strait, R.S.

    1995-04-01

    The 1994 National Academy of Sciences study open-quotes Management and Disposition of Excess Weapons Plutoniumclose quotes defined options for reducing the national and international proliferation risks of materials declared excess to the nuclear weapons program. This report proposes criteria for assessing the proliferation resistance of these options. The criteria are general, encompassing all stages of the disposition process from storage through intermediate processing to final disposition including the facilities, processing technologies and materials, the level of safeguards for these materials, and the national/subnational threat to the materials

  15. Evaluation of proliferation resistance using the INPRO methodology

    International Nuclear Information System (INIS)

    Yang, Myung Seung; Park, Joo Hwan; Ko, Won Il; Song, Kee Chan; Choi, Kun Mo; Kim, Jin Kyoung

    2007-01-01

    The IAEA launched the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) and developed the INPRO Methodology to provide guidelines and to assess the characteristics of a future innovative nuclear energy system in areas such as safety, economics, waste management, and proliferation resistance. The proliferation resistance area of the INPRO Methodology is reviewed here, and modifications for further improvements are proposed. The evaluation metrics including the evaluation parameters, evaluation scales and acceptance limits are developed for a practical application of the methodology to assess the proliferation resistance. The proliferation resistant characteristics of the DUPIC fuel cycle are assessed by applying the modified INPRO Methodology based on the developed evaluation metrics and acceptance criteria. The evaluation procedure and the metrics can be utilized as a reference for an evaluation of the proliferation resistance of a future innovative nuclear energy system

  16. Assessment of glucose metabolism and cellular proliferation in multiple myeloma: a first report on combined 18F-FDG and 18F-FLT PET/CT imaging.

    Science.gov (United States)

    Sachpekidis, C; Goldschmidt, H; Kopka, K; Kopp-Schneider, A; Dimitrakopoulou-Strauss, A

    2018-04-10

    Despite the significant upgrading in recent years of the role of 18 F-FDG PET/CT in multiple myeloma (MM) diagnostics, there is a still unmet need for myeloma-specific radiotracers. 3'-Deoxy-3'-[ 18 F]fluorothymidine ( 18 F-FLT) is the most studied cellular proliferation PET agent, considered a potentially new myeloma functional imaging tracer. The aim of this pilot study was to evaluate 18 F-FLT PET/CT in imaging of MM patients, in the context of its combined use with 18 F-FDG PET/CT. Eight patients, four suffering from symptomatic MM and four suffering from smoldering MM (SMM), were enrolled in the study. All patients underwent 18 F-FDG PET/CT and 18 F-FLT PET/CT imaging by means of static (whole body) and dynamic PET/CT of the lower abdomen and pelvis (dPET/CT) in two consecutive days. The evaluation of PET/CT studies was based on qualitative evaluation, semi-quantitative (SUV) calculation, and quantitative analysis based on two-tissue compartment modeling. 18 F-FDG PET/CT demonstrated focal, 18 F-FDG avid, MM-indicative bone marrow lesions in five patients. In contrary, 18 F-FLT PET/CT showed focal, 18 F-FLT avid, myeloma-indicative lesions in only two patients. In total, 48 18 F-FDG avid, focal, MM-indicative lesions were detected with 18 F-FDG PET/CT, while 17 18 F-FLT avid, focal, MM-indicative lesions were detected with 18 F-FLT PET/CT. The number of myeloma-indicative lesions was significantly higher for 18 F-FDG PET/CT than for 18 F-FLT PET/CT. A common finding was a mismatch of focally increased 18 F-FDG uptake and reduced 18 F-FLT uptake (lower than the surrounding bone marrow). Moreover, 18 F-FLT PET/CT was characterized by high background activity in the bone marrow compartment, further complicating the evaluation of bone marrow lesions. Semi-quantitative evaluation revealed that both SUV mean and SUV max were significantly higher for 18 F-FLT than for 18 F-FDG in both MM lesions and reference tissue. SUV values were higher in MM lesions than in

  17. Expression of MiR-9 promotes proliferation, migration and ...

    African Journals Online (AJOL)

    Purpose: To investigate the effect of miR-9 on the proliferation, differentiation and migration of human neural stem cells (NSCs). Methods: The expression of miR-9 was investigated by quantitative real-time polymerase chain reaction (RT-PCR). Cell proliferation was assessed by cell counting kit-8 (CCK8) assay, while cell ...

  18. Twenty years of the Non-proliferation Treaty

    International Nuclear Information System (INIS)

    Goldblat, Jozef.

    1990-01-01

    The report assesses the achievements of the Non-proliferation Treaty (NPT) and discusses ways in which the non-proliferation regime could be strenghtened. It recommends a series of measures to be taken by the parties of the Treaty, both nuclear and non-nuclear weapons states, with a view to reinforcing the Treaty and achieving its universality. 198 refs

  19. Optimal Paths in Gliding Flight

    Science.gov (United States)

    Wolek, Artur

    Underwater gliders are robust and long endurance ocean sampling platforms that are increasingly being deployed in coastal regions. This new environment is characterized by shallow waters and significant currents that can challenge the mobility of these efficient (but traditionally slow moving) vehicles. This dissertation aims to improve the performance of shallow water underwater gliders through path planning. The path planning problem is formulated for a dynamic particle (or "kinematic car") model. The objective is to identify the path which satisfies specified boundary conditions and minimizes a particular cost. Several cost functions are considered. The problem is addressed using optimal control theory. The length scales of interest for path planning are within a few turn radii. First, an approach is developed for planning minimum-time paths, for a fixed speed glider, that are sub-optimal but are guaranteed to be feasible in the presence of unknown time-varying currents. Next the minimum-time problem for a glider with speed controls, that may vary between the stall speed and the maximum speed, is solved. Last, optimal paths that minimize change in depth (equivalently, maximize range) are investigated. Recognizing that path planning alone cannot overcome all of the challenges associated with significant currents and shallow waters, the design of a novel underwater glider with improved capabilities is explored. A glider with a pneumatic buoyancy engine (allowing large, rapid buoyancy changes) and a cylindrical moving mass mechanism (generating large pitch and roll moments) is designed, manufactured, and tested to demonstrate potential improvements in speed and maneuverability.

  20. Perfect discretization of path integrals

    International Nuclear Information System (INIS)

    Steinhaus, Sebastian

    2012-01-01

    In order to obtain a well-defined path integral one often employs discretizations. In the case of General Relativity these generically break diffeomorphism symmetry, which has severe consequences since these symmetries determine the dynamics of the corresponding system. In this article we consider the path integral of reparametrization invariant systems as a toy example and present an improvement procedure for the discretized propagator. Fixed points and convergence of the procedure are discussed. Furthermore we show that a reparametrization invariant path integral implies discretization independence and acts as a projector onto physical states.

  1. Perfect discretization of path integrals

    Science.gov (United States)

    Steinhaus, Sebastian

    2012-05-01

    In order to obtain a well-defined path integral one often employs discretizations. In the case of General Relativity these generically break diffeomorphism symmetry, which has severe consequences since these symmetries determine the dynamics of the corresponding system. In this article we consider the path integral of reparametrization invariant systems as a toy example and present an improvement procedure for the discretized propagator. Fixed points and convergence of the procedure are discussed. Furthermore we show that a reparametrization invariant path integral implies discretization independence and acts as a projector onto physical states.

  2. Non-proliferation

    International Nuclear Information System (INIS)

    Deiseroth, D.; Gustafsson, S.

    1993-01-01

    The issue of Nuclear Non Proliferation has been moved to a leading place on the contemporary international security agenda. What about the situation of nuclear weapons and nuclear technology in Russia, Kazakhstan, Ukraine and Belorussia? Why did the IAEA-inspectors totally failed to discover any sign of Iraq's clandestine nuclear-weapon programme before the Gulf War? Do the NATO and their nuclear power states violate Art. VI of the Non-Proliferation-Treaty (NPT), because they are - despite the end of the cold war - not willing to renounce of the ''option of the first use of nuclear weapons''? Does the NPT establish a form of nuclear apartheid? What will be the situation if the NPT-Extension-Conference in 1995 will be unable to obtain a majority of the parties for any one extension proposal? Do we need a new international nuclear control agency with severe powers, a sort of nuclear Interpol? The Colloquium ''Saving NPT and abolishing Nuclear Weapons'', held in Stockholm in September 1992, organized by the Swedish and the German Sections of IALANA, tried to analyse some of the raised issues. (orig.) [de

  3. Non Proliferation of Nuclear

    International Nuclear Information System (INIS)

    Bambang S Irawan

    2004-01-01

    Non-Proliferation Treaty of Nuclear Weapons is the international community's efforts to maintain the security of the world, in order to prevent the spread of nuclear technology and the use of nuclear weapons, promoting cooperation for the use of nuclear peaceful purposes, build mutual trust (Confidence Building Measures) as well as to achieve the ultimate goal of disarmament overall (General and Complete Disarmament). Addressing the post-WTC tragedy, 11 September 2001, the Indonesian government should set up a National Measures (National Action Plan), among others formed the National Security Council and NBC Counter Proliferation Unit, or the National Authority for Nuclear Treaty, preparing national legislation, to prevent the abuse nuclear materials for terrorist acts, prevent Illicit Trafficking of Nuclear materials, developed a National Preparedness and Emergency Response Management in the event of a nuclear accident or attack by the use of nuclear terrorism. Importance of a National Action Plan meant the existence of a national commitment in the context of compliance with treaties and conventions which have been ratified relating to safety, security, safeguards towards a general and complete disarmament, to safeguard national security and maintain peace (safeguards) international

  4. Initiatives for proliferation prevention

    International Nuclear Information System (INIS)

    1997-04-01

    Preventing the proliferation of weapons of mass destruction is a central part of US national security policy. A principal instrument of the Department of Energy's (DOE's) program for securing weapons of mass destruction technology and expertise and removing incentives for scientists, engineers and technicians in the newly independent states (NIS) of the former Soviet Union to go to rogue countries or assist terrorist groups is the Initiatives for Proliferation Prevention (IPP). IPP was initiated pursuant to the 1994 Foreign Operations Appropriations Act. IPP is a nonproliferation program with a commercialization strategy. IPP seeks to enhance US national security and to achieve nonproliferation objectives by engaging scientists, engineers and technicians from former NIS weapons institutes; redirecting their activities in cooperatively-developed, commercially viable non-weapons related projects. These projects lead to commercial and economic benefits for both the NIS and the US IPP projects are funded in Russian, Ukraine, Kazakhstan and Belarus. This booklet offers an overview of the IPP program as well as a sampling of some of the projects which are currently underway

  5. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume III. Resources and fuel cycle facilities

    International Nuclear Information System (INIS)

    1980-06-01

    The ability of uranium supply and the rest of the nuclear fuel cycle to meet the demand for nuclear power is an important consideration in future domestic and international planning. Accordingly, the purpose of this assessment is to evaluate the adequacy of potential supply for various nuclear resources and fuel cycle facilities in the United States and in the world outside centrally planned economy areas (WOCA). Although major emphasis was placed on uranium supply and demand, material resources (thorium and heavy water) and facility resources (separative work, spent fuel storage, and reprocessing) were also considered

  6. Nuclear proliferation and civilian nuclear power. Report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    International Nuclear Information System (INIS)

    1980-06-01

    This volume of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power - generating capability and one without

  7. Separation of nuclear power from nuclear proliferation

    International Nuclear Information System (INIS)

    Starr, C.

    1978-01-01

    A successful development of the proposed combination of the Fast Breeder Reactor and the CIVEX fuel reprocessing facility would provide an economical nuclear power source for many centuries which inherently separates nuclear power from the issue of weapons material diversion and proliferation. Further, by so doing, it permits great flexibility in international and national planning for nuclear power, as the issues of fuel dependence and terrorist and subnational diversions disappear. In addition, the expansion of the FBR/CIVEX system would eat into the LWR spent fuel stockpile, diminishing steadily this relatively accessible plutonium source. And finally, a rapid development of the FBR/CIVEX for the above reasons would substantially reduce the worldwide concern as to the adequacy of uranium ore supply. From a historical view, it would restore fast reactor development to the path originally foreseen in the programs of worldwide nuclear energy authorities, including the Atomic Energy Commission during its first two decades of existence

  8. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials.

  9. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume IX. Reactor and fuel cycle descriptions

    International Nuclear Information System (INIS)

    1979-12-01

    The Nonproliferation Alternative Systems Assessment Program (NASAP) has characterized and assessed various reactor/fuel-cycle systems. Volume IX provides, in summary form, the technical descriptions of the reactor/fuel-cycle systems studied. This includes the status of the system technology, as well as a discussion of the safety, environmental, and licensing needs from a technical perspective. This information was then used in developing the research, development, and demonstration (RD and D) program, including its cost and time frame, to advance the existing technology to the level needed for commercial use. Wherever possible, the cost data are given as ranges to reflect the uncertainties in the estimates. Volume IX is divided into three sections: Chapter 1, Reactor Systems; Chapter 2, Fuel-Cycle Systems; and the Appendixes. Chapter 1 contains the characterizations of the following 12 reactor types: light-water reactor; heavy-water reactor; water-cooled breeder reactor; high-temperature gas-cooled reactor; gas-cooled fast reactor; liquid-metal fast breeder reactor; spectral-shift-controlled reactor; accelerator-driven reactor; molten-salt reactor; gaseous-core reactor; tokamak fusion-fisson hybrid reactor; and fast mixed-spectrum reactor. Chapter 2 contains similar information developed for fuel-cycle facilities in the following categories: mining and milling; conversion and enrichment; fuel fabrication; spent fuel reprocessing; waste handling and disposal; and transportation of nuclear materials

  10. User requirements for innovative nuclear reactors and fuel cycle technologies in the area of economics, environment, safety, waste management, proliferation resistance and cross cutting issues, and methodology for innovative technologies assessment

    International Nuclear Information System (INIS)

    Kupitz, Juergen; Depisch, Frank; Allan, Colin

    2003-01-01

    The IAEA General Conference in 2000 has invited ''all interested Member States to combine their efforts under the aegis of the Agency in considering the issues of the nuclear fuel cycle, in particular by examining innovative and proliferation-resistant nuclear technology''. In response to this invitation, the IAEA initiated an ''International Project on Innovative Nuclear Reactors and Fuel Cycles'', INPRO. The overall objectives of INPRO is to help to ensure that nuclear energy is available to contribute in fulfilling in a sustainable manner energy needs in the 21st century, and to bring together all interested Member States, both technology holders and technology users, to consider jointly the international and national actions required to achieve desired innovations in nuclear reactors and fuel cycles that use sound and economically competitive technology. Phase-I of INPRO was initiated in May 2001. During Phase-I, work was subdivided in two sub phase: Phase 1A (finished in June 2003) and Phase 1B (started in June 2003). Phase 1A dealt with the definition of Basic Principles, User Requirements and Criteria, and the development of a methodology for the evaluation of innovative nuclear technologies. In Phase 1A, task groups for several areas were established: (a) Prospects and Potentials of Nuclear Power, (b) Economics; (c) Sustainability and Environment, (d) Safety of Nuclear Installations, (e) Waste Management, (f) Proliferation Resistance, (g) Crosscutting issues and (h) for the Methodology for Assessment. In Phase-IB evaluations of innovative nuclear energy technologies will be performed by Member States against the INPRO Basic Principles, User Requirements and Criteria. This paper summarizes the results achieved in the Phase 1A of INPRO and is a cooperative effort of the INPRO team, consisting of all INPRO cost free experts and task managers. (author)

  11. Uncertainties in Nuclear Proliferation Modeling

    International Nuclear Information System (INIS)

    Kim, Chul Min; Yim, Man-Sung; Park, Hyeon Seok

    2015-01-01

    There have been various efforts in the research community to understand the determinants of nuclear proliferation and develop quantitative tools to predict nuclear proliferation events. Such systematic approaches have shown the possibility to provide warning for the international community to prevent nuclear proliferation activities. However, there are still large debates for the robustness of the actual effect of determinants and projection results. Some studies have shown that several factors can cause uncertainties in previous quantitative nuclear proliferation modeling works. This paper analyzes the uncertainties in the past approaches and suggests future works in the view of proliferation history, analysis methods, and variable selection. The research community still lacks the knowledge for the source of uncertainty in current models. Fundamental problems in modeling will remain even other advanced modeling method is developed. Before starting to develop fancy model based on the time dependent proliferation determinants' hypothesis, using graph theory, etc., it is important to analyze the uncertainty of current model to solve the fundamental problems of nuclear proliferation modeling. The uncertainty from different proliferation history coding is small. Serious problems are from limited analysis methods and correlation among the variables. Problems in regression analysis and survival analysis cause huge uncertainties when using the same dataset, which decreases the robustness of the result. Inaccurate variables for nuclear proliferation also increase the uncertainty. To overcome these problems, further quantitative research should focus on analyzing the knowledge suggested on the qualitative nuclear proliferation studies

  12. Proliferation: myth or reality?; La proliferation: mythe ou realite?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-07-01

    This article analyzes the proliferation approach, its technical condition and political motivation, and the share between the myth (political deception, assumptions and extrapolations) and the reality of proliferation. Its appreciation is complicated by the irrational behaviour of some political actors and by the significant loss of the non-use taboo. The control of technologies is an important element for proliferation slowing down but an efficient and autonomous intelligence system remains indispensable. (J.S.)

  13. An Introduction to Path Analysis

    Science.gov (United States)

    Wolfe, Lee M.

    1977-01-01

    The analytical procedure of path analysis is described in terms of its use in nonexperimental settings in the social sciences. The description assumes a moderate statistical background on the part of the reader. (JKS)

  14. Probabilistic simulation of fermion paths

    International Nuclear Information System (INIS)

    Zhirov, O.V.

    1989-01-01

    Permutation symmetry of fermion path integral allows (while spin degrees of freedom are ignored) to use in its simulation any probabilistic algorithm, like Metropolis one, heat bath, etc. 6 refs., 2 tabs

  15. Nuclear proliferation and civilian nuclear power: report of the Nonproliferation Alternative Systems Assessment Program. Volume VI. Safety and environmental considerations for licensing

    International Nuclear Information System (INIS)

    1979-12-01

    Volume 6 of the Nonproliferation Alternative Systems Assessment Program report addresses safety and environmental considerations in licensing the principal alternative nuclear reactors and fuel cycles in the United States for large-scale commercial nuclear power plants. In addition, this volume examines the safety and environmental considerations for licensing fuel service centers. These centers, which have been proposed for controlling sensitive fuel-cycle facilities and special nuclear materials, would contain a combination of such facilities as reprocessing plants, fabrication plants, and reactors. For this analysis, two fuel service center concepts were selected - one with power-generating capability and one without. This volume also provides estimates of the time required for development of large-scale commercial reactor systems to reach the construction permit application stage and for fuel-cycle facilities to reach the operating license application stage, which is a measure of the relative technical status of alternative nuclear systems

  16. Formal language constrained path problems

    Energy Technology Data Exchange (ETDEWEB)

    Barrett, C.; Jacob, R.; Marathe, M.

    1997-07-08

    In many path finding problems arising in practice, certain patterns of edge/vertex labels in the labeled graph being traversed are allowed/preferred, while others are disallowed. Motivated by such applications as intermodal transportation planning, the authors investigate the complexity of finding feasible paths in a labeled network, where the mode choice for each traveler is specified by a formal language. The main contributions of this paper include the following: (1) the authors show that the problem of finding a shortest path between a source and destination for a traveler whose mode choice is specified as a context free language is solvable efficiently in polynomial time, when the mode choice is specified as a regular language they provide algorithms with improved space and time bounds; (2) in contrast, they show that the problem of finding simple paths between a source and a given destination is NP-hard, even when restricted to very simple regular expressions and/or very simple graphs; (3) for the class of treewidth bounded graphs, they show that (i) the problem of finding a regular language constrained simple path between source and a destination is solvable in polynomial time and (ii) the extension to finding context free language constrained simple paths is NP-complete. Several extensions of these results are presented in the context of finding shortest paths with additional constraints. These results significantly extend the results in [MW95]. As a corollary of the results, they obtain a polynomial time algorithm for the BEST k-SIMILAR PATH problem studied in [SJB97]. The previous best algorithm was given by [SJB97] and takes exponential time in the worst case.

  17. Perfect discretization of path integrals

    OpenAIRE

    Steinhaus, Sebastian

    2011-01-01

    In order to obtain a well-defined path integral one often employs discretizations. In the case of General Relativity these generically break diffeomorphism symmetry, which has severe consequences since these symmetries determine the dynamics of the corresponding system. In this article we consider the path integral of reparametrization invariant systems as a toy example and present an improvement procedure for the discretized propagator. Fixed points and convergence of the procedure are discu...

  18. Path integration in conical space

    International Nuclear Information System (INIS)

    Inomata, Akira; Junker, Georg

    2012-01-01

    Quantum mechanics in conical space is studied by the path integral method. It is shown that the curvature effect gives rise to an effective potential in the radial path integral. It is further shown that the radial path integral in conical space can be reduced to a form identical with that in flat space when the discrete angular momentum of each partial wave is replaced by a specific non-integral angular momentum. The effective potential is found proportional to the squared mean curvature of the conical surface embedded in Euclidean space. The path integral calculation is compatible with the Schrödinger equation modified with the Gaussian and the mean curvature. -- Highlights: ► We study quantum mechanics on a cone by the path integral approach. ► The path integral depends only on the metric and the curvature effect is built in. ► The approach is consistent with the Schrödinger equation modified by an effective potential. ► The effective potential is found to be of the “Jensen–Koppe” and “da Costa” type.

  19. Path integrals on curved manifolds

    International Nuclear Information System (INIS)

    Grosche, C.; Steiner, F.

    1987-01-01

    A general framework for treating path integrals on curved manifolds is presented. We also show how to perform general coordinate and space-time transformations in path integrals. The main result is that one has to subtract a quantum correction ΔV ∝ ℎ 2 from the classical Lagrangian L, i.e. the correct effective Lagrangian to be used in the path integral is L eff = L-ΔV. A general prescription for calculating the quantum correction ΔV is given. It is based on a canonical approach using Weyl-ordering and the Hamiltonian path integral defined by the midpoint prescription. The general framework is illustrated by several examples: The d-dimensional rotator, i.e. the motion on the sphere S d-1 , the path integral in d-dimensional polar coordinates, the exact treatment of the hydrogen atom in R 2 and R 3 by performing a Kustaanheimo-Stiefel transformation, the Langer transformation and the path integral for the Morse potential. (orig.)

  20. Path-based Queries on Trajectory Data

    DEFF Research Database (Denmark)

    Krogh, Benjamin Bjerre; Pelekis, Nikos; Theodoridis, Yannis

    2014-01-01

    In traffic research, management, and planning a number of path-based analyses are heavily used, e.g., for computing turn-times, evaluating green waves, or studying traffic flow. These analyses require retrieving the trajectories that follow the full path being analyzed. Existing path queries cannot...... sufficiently support such path-based analyses because they retrieve all trajectories that touch any edge in the path. In this paper, we define and formalize the strict path query. This is a novel query type tailored to support path-based analysis, where trajectories must follow all edges in the path...... a specific path by only retrieving data from the first and last edge in the path. To correctly answer strict path queries existing network-constrained trajectory indexes must retrieve data from all edges in the path. An extensive performance study of NETTRA using a very large real-world trajectory data set...

  1. The nuclear proliferation

    International Nuclear Information System (INIS)

    Gere, F.

    1995-04-01

    In this book is detailed the beginning of nuclear military power, with the first bomb of Hiroshima, the different ways of getting uranium 235 and plutonium 239, and how the first countries (Usa, Ussr, China, United kingdom, France) got nuclear weapons. Then the most important part is reviewed with the details of non-proliferation treaty and the creation of IAEA to promote civilian nuclear power in the world and to control the use of plutonium and uranium in nuclear power plants. The cases of countries who reached the atom mastery, such Israel, South Africa, Pakistan, Iraq, North Korea, Argentina, Brazil, Iran, Algeria, Taiwan and the reasons which they wanted nuclear weapon for or why they gave up, are exposed

  2. Non-proliferation and nuclear cooperation - accomplishments and challenges

    International Nuclear Information System (INIS)

    Marshall, H.R. Jr.

    1983-01-01

    The purpose of this paper is to assess the accomplishments in non-proliferation and nuclear co-operation since the beginning of President Reagan's administration, and the challenges remaining to be met in those fields. (NEA) [fr

  3. Co-occurrence of tobacco product use, substance use, and mental health problems among adults: Findings from Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study.

    Science.gov (United States)

    Conway, Kevin P; Green, Victoria R; Kasza, Karin A; Silveira, Marushka L; Borek, Nicolette; Kimmel, Heather L; Sargent, James D; Stanton, Cassandra; Lambert, Elizabeth; Hilmi, Nahla; Reissig, Chad J; Jackson, Kia J; Tanski, Susanne E; Maklan, David; Hyland, Andrew J; Compton, Wilson M

    2017-08-01

    Although non-cigarette tobacco product use is increasing among U.S. adults, their associations with substance use and mental health problems are unclear. This study examined co-occurrence of tobacco use, substance use, and mental health problems, and its moderation by gender, among 32,202U.S. adults from Wave 1 (2013-2014) of the nationally representative longitudinal Population Assessment of Tobacco and Health (PATH) Study. Participants self-reported current cigarette, e-cigarette, traditional cigar, cigarillo, filtered cigar, hookah, smokeless tobacco and other tobacco product use; past year alcohol, marijuana, and other drug use; and past year substance use, internalizing and externalizing problems. Compared to non-current tobacco users, current users were more likely to report alcohol or drug use (adjusted odds ratio (AOR)=2.6; 95% confidence interval (CI): 2.3, 2.9), with the strongest associations observed for cigarillo and hookah users. Across all tobacco product groups, users were more likely to report internalizing (AOR=1.9; 95% CI: 1.7, 2.1), externalizing (AOR=1.6; 95% CI: 1.5, 1.8), and substance use (AOR=3.4; 95% CI: 2.9, 4.1) problems than non-users. Gender moderated many of these associations and, of these, all non-cigarette tobacco product associations were stronger among females. This nationally representative study of U.S. adults is the first to comprehensively document tobacco use, substance use, and mental health comorbidities across the range of currently available tobacco products, while also demonstrating that female tobacco users are at increased risk for substance use and mental health problems. These findings may point to gender differences in vulnerability and suggest that interventions incorporate gender-specific approaches. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Path integration on hyperbolic spaces

    Energy Technology Data Exchange (ETDEWEB)

    Grosche, C [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    1991-11-01

    Quantum mechanics on the hyperbolic spaces of rank one is discussed by path integration technique. Hyperbolic spaces are multi-dimensional generalisation of the hyperbolic plane, i.e. the Poincare upper half-plane endowed with a hyperbolic geometry. We evalute the path integral on S{sub 1} {approx equal} SO (n,1)/SO(n) and S{sub 2} {approx equal} SU(n,1)/S(U(1) x U(n)) in a particular coordinate system, yielding explicitly the wave-functions and the energy spectrum. Futhermore we can exploit a general property of all these spaces, namely that they can be parametrized by a pseudopolar coordinate system. This allows a separation in path integration over spheres and an additional path integration over the remaining hyperbolic coordinate, yielding effectively a path integral for a modified Poeschl-Teller potential. Only continuous spectra can exist in all the cases. For all the hyperbolic spaces of rank one we find a general formula for the largest lower bound (zero-point energy) of the spectrum which is given by E{sub O} = h{sup 2} /8m(m{sub {alpha}} +2m{sub 2} {alpha}){sup 2} (m {alpha} and m{sub 2}{alpha} denote the dimension of the root subspace corresponding to the roots {alpha} and 2{alpha}, respectively). I also discuss the case, where a constant magnetic field on H{sup n} is incorporated. (orig.).

  5. Path integration on hyperbolic spaces

    International Nuclear Information System (INIS)

    Grosche, C.

    1991-11-01

    Quantum mechanics on the hyperbolic spaces of rank one is discussed by path integration technique. Hyperbolic spaces are multi-dimensional generalisation of the hyperbolic plane, i.e. the Poincare upper half-plane endowed with a hyperbolic geometry. We evalute the path integral on S 1 ≅ SO (n,1)/SO(n) and S 2 ≅ SU(n,1)/S[U(1) x U(n)] in a particular coordinate system, yielding explicitly the wave-functions and the energy spectrum. Futhermore we can exploit a general property of all these spaces, namely that they can be parametrized by a pseudopolar coordinate system. This allows a separation in path integration over spheres and an additional path integration over the remaining hyperbolic coordinate, yielding effectively a path integral for a modified Poeschl-Teller potential. Only continuous spectra can exist in all the cases. For all the hyperbolic spaces of rank one we find a general formula for the largest lower bound (zero-point energy) of the spectrum which is given by E O = h 2 /8m(m α +2m 2 α) 2 (m α and m 2 α denote the dimension of the root subspace corresponding to the roots α and 2α, respectively). I also discuss the case, where a constant magnetic field on H n is incorporated. (orig.)

  6. Limiting Future Proliferation and Security Risks

    International Nuclear Information System (INIS)

    Bari, R.

    2011-01-01

    A major new technical tool for evaluation of proliferation and security risks has emerged over the past decade as part the activities of the Generation IV International Forum. The tool has been developed by a consensus group from participating countries and organizations and is termed the Proliferation Resistance and Physical Protection (PR and PP) Evaluation Methodology. The methodology defines a set of challenges, analyzes system response to these challenges, and assesses outcomes. The challenges are the threats posed by potential actors (proliferant states or sub-national adversaries). It is of paramount importance in an evaluation to establish the objectives, capabilities, resources, and strategies of the adversary as well as the design and protection contexts. Technical and institutional characteristics are both used to evaluate the response of the system and to determine its resistance against proliferation threats and robustness against sabotage and terrorism threats. The outcomes of the system response are expressed in terms of a set of measures, which thereby define the PR and PP characteristics of the system. This paper summarizes results of applications of the methodology to nuclear energy systems including reprocessing facilities and large and small modular reactors. The use of the methodology in the design phase a facility will be discussed as it applies to future safeguards concepts.

  7. Thalidomide increases human keratinocyte migration and proliferation.

    Science.gov (United States)

    Nasca, M R; O'Toole, E A; Palicharla, P; West, D P; Woodley, D T

    1999-11-01

    Thalidomide is reported to have therapeutic utility in the treatment of pyoderma gangrenosum, Behçet's disease, aphthous ulcers, and skin wounds. We investigated the effect of thalidomide on human keratinocyte proliferation and migration, two early and critical events in the re-epithelialization of skin wounds. Thalidomide at concentrations less than 1 microM did not affect keratinocyte viability. Using a thymidine incorporation assay, we found that thalidomide, at therapeutic concentrations, induced more than a 2. 5-fold increase in the proliferative potential of the cells. Keratinocyte migration was assessed by two independent motility assays: a colloidal gold assay and an in vitro scratch assay. At optimal concentrations, thalidomide increased keratinocyte migration on a collagen matrix more than 2-fold in the colloidal gold assay and more than 3-fold in the scratch assay over control. Although pro-migratory, thalidomide did not alter the level of metalloproteinase-9 secreted into culture medium. Thalidomide did, however, induce a 2-4-fold increase in keratinocyte-derived interleukin-8, a pro-migratory cellular autocrine factor. Human keratinocyte migration and proliferation are essential for re-epithelialization of skin wounds. Interleukin-8 increases human keratinocyte migration and proliferation and is chemotactic for keratinocytes. Therefore, thalidomide may modulate keratinocyte proliferation and motility by a chemokine-dependent pathway.

  8. Path-integral approach to resonant electron-molecule scattering

    International Nuclear Information System (INIS)

    Winterstetter, M.; Domcke, W.

    1993-01-01

    A path-integral formulation of resonant electron-molecule scattering is developed within the framework of the projection-operator formalism of scattering theory. The formation and decay of resonances is treated in real time as a quantum-mechanical electronic-tunneling process, modified by the coupling of the electronic motion with the nuclear degrees of freedom. It is shown that the electronic continuum can be summed over in the path-integral formulation, resulting formally in the path integral for an effective two-state system with coupling to vibrations. The harmonic-oscillator approximation is adopted for the vibrational motion in the present work. Approximation methods are introduced which render the numerical evaluation of the sum over paths feasible for up to ∼10 3 elementary time slices. The theory is numerically realized for simple but nontrivial models representing the 2 Π g d-wave shape resonance in e - +N 2 collisions and the 2 Σ u + p-wave shape resonance in e - +H 2 collisions, respectively. The accuracy of the path-integral results is assessed by comparison with exact numerical reference data for these models. The essential virtue of the path-integral approach is the fact that the computational effort scales at most linearly with the number of vibrational degrees of freedom. The path-integral method is thus well suited to treat electron collisions with polyatomic molecules and molecular aggregates

  9. Nuclear proliferation: linkages and solutions

    International Nuclear Information System (INIS)

    Quester, G.H.

    1979-01-01

    Nuclear proliferation must be periodically re-examined as a moral as well as a practical foreign policy dilemma. The question is asked whether proliferation precludes a safe and peaceful world, or if a halt to proliferation is adequate without other arms control. The moral dilemma in foreign policy arises over the need to make practical choices which often serve one goal while sacrificing another. The ramifications of nuclear proliferation are examined and the conclusions reached that it is not an acceptable option. It is also decided that, because general disarmament steps will be more difficult to achieve, the world may have to accept a small number of nuclear arsenals as the price of state sovereignties. A high priority for making the effort to prevent proliferation is advised. 8 references

  10. Path Integrals in Quantum Mechanics

    International Nuclear Information System (INIS)

    Louko, J

    2005-01-01

    Jean Zinn-Justin's textbook Path Integrals in Quantum Mechanics aims to familiarize the reader with the path integral as a calculational tool in quantum mechanics and field theory. The emphasis is on quantum statistical mechanics, starting with the partition function Tr exp(-β H) and proceeding through the diffusion equation to barrier penetration problems and their semiclassical limit. The 'real time' path integral is defined via analytic continuation and used for the path-integral representation of the nonrelativistic S-matrix and its perturbative expansion. Holomorphic and Grassmannian path integrals are introduced and applied to nonrelativistic quantum field theory. There is also a brief discussion of path integrals in phase space. The introduction includes a brief historical review of path integrals, supported by a bibliography with some 40 entries. As emphasized in the introduction, mathematical rigour is not a central issue in the book. This allows the text to present the calculational techniques in a very readable manner: much of the text consists of worked-out examples, such as the quartic anharmonic oscillator in the barrier penetration chapter. At the end of each chapter there are exercises, some of which are of elementary coursework type, but the majority are more in the style of extended examples. Most of the exercises indeed include the solution or a sketch thereof. The book assumes minimal previous knowledge of quantum mechanics, and some basic quantum mechanical notation is collected in an appendix. The material has a large overlap with selected chapters in the author's thousand-page textbook Quantum Field Theory and Critical Phenomena (2002 Oxford: Clarendon). The stand-alone scope of the present work has, however, allowed a more focussed organization of this material, especially in the chapters on, respectively, holomorphic and Grassmannian path integrals. In my view the book accomplishes its aim admirably and is eminently usable as a textbook

  11. From path integrals to anyons

    International Nuclear Information System (INIS)

    Canright, G.S.

    1992-01-01

    I offer a pedagogical review of the homotopy arguments for fractional statistics in two dimensions. These arguments arise naturally in path-integral language since they necessarily consider the properties of paths rather than simply permutations. The braid group replaces the permutation group as the basic structure for quantum statistics; hence properties of the braid group on several surfaces are briefly discussed. Finally, the question of multiple (real-space) occupancy is addressed; I suggest that the ''traditional'' treatment of this question (ie, an assumption that many-anyon wavefunctions necessarily vanish for multiple occupancy) needs reexamination

  12. Isomorphisms and traversability of directed path graphs

    NARCIS (Netherlands)

    Broersma, Haitze J.; Li, Xueliang; Li, X.

    1998-01-01

    The concept of a line digraph is generalized to that of a directed path graph. The directed path graph $\\forw P_k(D)$ of a digraph $D$ is obtained by representing the directed paths on $k$ vertices of $D$ by vertices. Two vertices are joined by an arc whenever the corresponding directed paths in $D$

  13. Thorium cycles and proliferation

    International Nuclear Information System (INIS)

    Lovins, A.B.

    1979-01-01

    This paper analyzes several prevalent misconceptions about nuclear fuel cycles that breed fissile uranium-233 from thorium. Its main conclusions are: U-233, despite the gamma radioactivity of associated isotopes, is a rather attractive material for making fission bombs, and is a credible material for subnational as well as national groups to use for this purpose; (2) pure thorium cycles, which in effect merely substitute U-233 for Pu, would take many decades and much U to establish, and offer no significant safeguards advantage over Pu, cycles; (3) denatured Th-U cycles, which dilute the U-233 with inert U-238 to a level not directly usable in bombs, are not an effective safeguard even against subnational bomb-making; (4) several other features of mixed Th-U cycles are rather unattractive from a safeguards point of view; (5) thus, Th cycles of any kind are not a technical fix for proliferation (national or subnational) and, though probably more safeguardable than Pu cycles, are less so than once-through U cycles that entail no reprocessing; (6) while thorium cycles have some potential technical advantages, including flexibility, they cannot provide major savings in nuclear fuel resources compared to simpler ways of saving neutrons and U; and (7) while advocates of nuclear power may find Th cycles worth exploring, such cycles do not differ fundamentally from U cycles in any of the respects--including safeguards and fuel resources--that are relevant to the broader nuclear debate, and should not be euphorically embraced as if they did

  14. Does nuclear proliferation in Asia threaten the future of the NPT?

    International Nuclear Information System (INIS)

    Vandier, Pierre

    2005-01-01

    Asia is a region which presents all kinds of situation with respect to nuclear proliferation: nuclear countries, proliferating countries, countries non members of the NPT, countries violating the NPT, pacifist countries, threshold countries, and so on. Through an assessment of nuclear proliferation in Asia, the author first outlines the weaknesses of the Non Proliferation Treaty (NPT), and then discusses origins of tensions which may re-launch a nuclear arms race. In a third part, the author assesses the future of the Treaty within the arrangement for the struggle against nuclear proliferation as its has been strengthened in 2005

  15. Nuclear non proliferation and disarmament

    International Nuclear Information System (INIS)

    2000-01-01

    In the framework of the publication of a document on the ''weapons mastership, disarmament and non proliferation: the french action'', by the ministry of Foreign Affairs and the ministry of Defense, the French Documentation organization presents a whole document. This document describes and details the following topics: the conference on the treaty of non proliferation of nuclear weapons, the France, Usa and Non Governmental Organizations position, the threats of the proliferation, the french actions towards the disarmament, the disarmament in the world, a chronology and some bibliographic resources. (A.L.B.)

  16. International proliferation on nuclear weapons

    International Nuclear Information System (INIS)

    Hill, J.

    1977-01-01

    The subject is dealt with under the following headings: introduction; routes to proliferation (preparation of U 235 , Pu 239 , U 233 ); nuclear power fuel cycles and proliferation; the fast reactor fuel cycle; security aspects of the existing fuel cycle; the IAEA and the nuclear non-proliferation treaty. It is concluded that 'the basis for sound international control exists, and taken together with the further technical steps which will be taken to make the existing fuel cycles more robust against the diversion of materials by terrorists and the abuse of civil nuclear power programmes by governments, we have good reason to proceed now with the orderly exploitation of ...nuclear energy...'. (U.K.)

  17. Ki67 and proliferation in breast cancer.

    Science.gov (United States)

    Pathmanathan, Nirmala; Balleine, Rosemary L

    2013-06-01

    New approaches to the prognostic assessment of breast cancer have come from molecular profiling studies. A major feature of this work has been to emphasise the importance of cancer cell proliferation as a key discriminative indicator of recurrence risk for oestrogen receptor positive breast cancer in particular. Mitotic count scoring, as a component of histopathological grade, has long formed part of a routine evaluation of breast cancer biology. However, there is an increasingly compelling case to include a specific proliferation score in breast cancer pathology reports based on expression of the cell cycle regulated protein Ki67. Immunohistochemical staining for Ki67 is a widely available and economical test with good tolerance of pre-analytical variations and staining conditions. However, there is currently no evidence based protocol established to derive a reliable and informative Ki67 score for routine clinical use. In this circumstance, pathologists must establish a standardised framework for scoring Ki67 and communicating results to a multidisciplinary team.

  18. DiversePathsJ: diverse shortest paths for bioimage analysis.

    Science.gov (United States)

    Uhlmann, Virginie; Haubold, Carsten; Hamprecht, Fred A; Unser, Michael

    2018-02-01

    We introduce a formulation for the general task of finding diverse shortest paths between two end-points. Our approach is not linked to a specific biological problem and can be applied to a large variety of images thanks to its generic implementation as a user-friendly ImageJ/Fiji plugin. It relies on the introduction of additional layers in a Viterbi path graph, which requires slight modifications to the standard Viterbi algorithm rules. This layered graph construction allows for the specification of various constraints imposing diversity between solutions. The software allows obtaining a collection of diverse shortest paths under some user-defined constraints through a convenient and user-friendly interface. It can be used alone or be integrated into larger image analysis pipelines. http://bigwww.epfl.ch/algorithms/diversepathsj. michael.unser@epfl.ch or fred.hamprecht@iwr.uni-heidelberg.de. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

  19. Non-proliferation and nuclear data

    International Nuclear Information System (INIS)

    Sowerby, M.G.

    1978-01-01

    A review is made of the problem of the proliferation of nuclear weapons with particular emphasis on proliferation and nuclear power. Some indications of the nuclear data requirements associated with methods of reducing proliferation risks are presented

  20. Spreading paths in partially observed social networks

    Science.gov (United States)

    Onnela, Jukka-Pekka; Christakis, Nicholas A.

    2012-03-01

    Understanding how and how far information, behaviors, or pathogens spread in social networks is an important problem, having implications for both predicting the size of epidemics, as well as for planning effective interventions. There are, however, two main challenges for inferring spreading paths in real-world networks. One is the practical difficulty of observing a dynamic process on a network, and the other is the typical constraint of only partially observing a network. Using static, structurally realistic social networks as platforms for simulations, we juxtapose three distinct paths: (1) the stochastic path taken by a simulated spreading process from source to target; (2) the topologically shortest path in the fully observed network, and hence the single most likely stochastic path, between the two nodes; and (3) the topologically shortest path in a partially observed network. In a sampled network, how closely does the partially observed shortest path (3) emulate the unobserved spreading path (1)? Although partial observation inflates the length of the shortest path, the stochastic nature of the spreading process also frequently derails the dynamic path from the shortest path. We find that the partially observed shortest path does not necessarily give an inflated estimate of the length of the process path; in fact, partial observation may, counterintuitively, make the path seem shorter than it actually is.

  1. Spreading paths in partially observed social networks.

    Science.gov (United States)

    Onnela, Jukka-Pekka; Christakis, Nicholas A

    2012-03-01

    Understanding how and how far information, behaviors, or pathogens spread in social networks is an important problem, having implications for both predicting the size of epidemics, as well as for planning effective interventions. There are, however, two main challenges for inferring spreading paths in real-world networks. One is the practical difficulty of observing a dynamic process on a network, and the other is the typical constraint of only partially observing a network. Using static, structurally realistic social networks as platforms for simulations, we juxtapose three distinct paths: (1) the stochastic path taken by a simulated spreading process from source to target; (2) the topologically shortest path in the fully observed network, and hence the single most likely stochastic path, between the two nodes; and (3) the topologically shortest path in a partially observed network. In a sampled network, how closely does the partially observed shortest path (3) emulate the unobserved spreading path (1)? Although partial observation inflates the length of the shortest path, the stochastic nature of the spreading process also frequently derails the dynamic path from the shortest path. We find that the partially observed shortest path does not necessarily give an inflated estimate of the length of the process path; in fact, partial observation may, counterintuitively, make the path seem shorter than it actually is.

  2. The experimental evaluation of the success path monitoring system

    International Nuclear Information System (INIS)

    Baker, S.C.; Marshall, E.C.; Reiersen, C.S.; Owre, F.; Gaudio, P.J. Jr.

    1988-01-01

    The Success Path Monitoring System (SPMS) is an advanced computer-based operator aid which is intended to enhance the operator's ability to handle plant disturbances effectively. It achieves this by providing an on-line assessment of both the status of critical safety functions and the status of appropriate success paths. A prototype version of SPMS has been implemented on the OECD Halden Project's PWR simulator, the objective being to test the SPMS in a realistic situation and to assess whether it performed in accordance with design expectations. 16 reactor operators were observed coping with complex transient scenarios both with, and without SPMS being available

  3. Nuclear proliferation and the near-nuclear countries

    International Nuclear Information System (INIS)

    Marwah, O.; Schulz, A.

    1975-01-01

    The process of nuclear proliferation and its consequences for the international political system is examined by focusing on the issues in the nuclear-strategic debate that divide first and second order states. Information is included on: the US-USSR arms race; SALT agreement; the Non-Proliferation Treaty; the nuclear aspirations and policies of India, Middle Eastern countries, South Africa, Japan, Brazil, and Argentina; and assessment of the risks related to the nuclear fuel cycle and nuclear weapons

  4. Stochastic control with rough paths

    International Nuclear Information System (INIS)

    Diehl, Joscha; Friz, Peter K.; Gassiat, Paul

    2017-01-01

    We study a class of controlled differential equations driven by rough paths (or rough path realizations of Brownian motion) in the sense of Lyons. It is shown that the value function satisfies a HJB type equation; we also establish a form of the Pontryagin maximum principle. Deterministic problems of this type arise in the duality theory for controlled diffusion processes and typically involve anticipating stochastic analysis. We make the link to old work of Davis and Burstein (Stoch Stoch Rep 40:203–256, 1992) and then prove a continuous-time generalization of Roger’s duality formula [SIAM J Control Optim 46:1116–1132, 2007]. The generic case of controlled volatility is seen to give trivial duality bounds, and explains the focus in Burstein–Davis’ (and this) work on controlled drift. Our study of controlled rough differential equations also relates to work of Mazliak and Nourdin (Stoch Dyn 08:23, 2008).

  5. Stochastic control with rough paths

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Joscha [University of California San Diego (United States); Friz, Peter K., E-mail: friz@math.tu-berlin.de [TU & WIAS Berlin (Germany); Gassiat, Paul [CEREMADE, Université Paris-Dauphine, PSL Research University (France)

    2017-04-15

    We study a class of controlled differential equations driven by rough paths (or rough path realizations of Brownian motion) in the sense of Lyons. It is shown that the value function satisfies a HJB type equation; we also establish a form of the Pontryagin maximum principle. Deterministic problems of this type arise in the duality theory for controlled diffusion processes and typically involve anticipating stochastic analysis. We make the link to old work of Davis and Burstein (Stoch Stoch Rep 40:203–256, 1992) and then prove a continuous-time generalization of Roger’s duality formula [SIAM J Control Optim 46:1116–1132, 2007]. The generic case of controlled volatility is seen to give trivial duality bounds, and explains the focus in Burstein–Davis’ (and this) work on controlled drift. Our study of controlled rough differential equations also relates to work of Mazliak and Nourdin (Stoch Dyn 08:23, 2008).

  6. Path modeling and process control

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar; Rodionova, O.; Pomerantsev, A.

    2007-01-01

    and having three or more stages. The methods are applied to a process control of a multi-stage production process having 25 variables and one output variable. When moving along the process, variables change their roles. It is shown how the methods of path modeling can be applied to estimate variables...... be performed regarding the foreseeable output property y, and with respect to an admissible range of correcting actions for the parameters of the next stage. In this paper the basic principles of path modeling is presented. The mathematics is presented for processes having only one stage, having two stages...... of the next stage with the purpose of obtaining optimal or almost optimal quality of the output variable. An important aspect of the methods presented is the possibility of extensive graphic analysis of data that can provide the engineer with a detailed view of the multi-variate variation in data....

  7. Factorization-algebraization-path integration

    International Nuclear Information System (INIS)

    Inomata, A.; Wilson, R.

    1986-01-01

    The authors review the method of factorization proposed by Schroedinger of a quantum mechanical second-order linear differential equation into a product of two first-order differential operators, often referred to as ladder operators, as well as the modifications made to Schroedinger's method by Infeld and Hull. They then review the group theoretical treatments proposed by Miller of the Schroedinger-Infeld-Hull factorizations and go on to demonstrate the application of dynamical symmetry to path integral calculations. 30 references

  8. The path of code linting

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Join the path of code linting and discover how it can help you reach higher levels of programming enlightenment. Today we will cover how to embrace code linters to offload cognitive strain on preserving style standards in your code base as well as avoiding error-prone constructs. Additionally, I will show you the journey ahead for integrating several code linters in the programming tools your already use with very little effort.

  9. Career path for operations personnel

    International Nuclear Information System (INIS)

    Asher, J.A.

    1985-01-01

    This paper explains how selected personnel can now obtain a Bachelor of Science degree in Physics with a Nuclear Power Operations option. The program went into effect the Fall of 1984. Another program was worked out in 1982 whereby students attending the Nuclear Operators Training Program could obtain an Associates of Science degree in Mechanical Engineering Technology at the end of two years of study. This paper presents tables and charts which describe these programs and outline the career path for operators

  10. Conditionally solvable path integral problems

    International Nuclear Information System (INIS)

    Grosche, C.

    1995-05-01

    Some specific conditionally exactly solvable potentials are discussed within the path integral formalism. They generalize the usually known potentials by the incorporation of a fractional power behaviour and strongly anharmonic terms. We find four different kinds of such potentials, the first is related to the Coulomb potential, the second is an anharmonic confinement potential, and the third and the fourth are related to the Manning-Rosen potential. (orig.)

  11. Path integrals in curvilinear coordinates

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1984-01-01

    Integration limits are studied for presenting the path integral curvilinear coordinates. For spherical (and topoloqically equivalent) coordinates it is shown that in formulas involving classical action in the exponent integration over all variables should be carried out within infinite limits. Another peculiarity is associated with appearance of the operator q which provides a complete definition of the wave functions out of the physical region. arguments are given upporting the validity of the cited statament in the general case

  12. Polygonal-path approximations on the path spaces of quantum-mechanical systems: properties of the polygonal paths

    International Nuclear Information System (INIS)

    Exner, P.; Kolerov, G.I.

    1981-01-01

    Properties of the subset of polygonal paths in the Hilbert space H of paths referring to a d-dimensional quantum-mechanical system are examined. Using the reproduction kernel technique we prove that each element of H is approximated by polygonal paths uniformly with respect to the ''norm'' of time-interval partitions. This result will be applied in the second part of the present paper to prove consistency of the uniform polygonal-path extension of the Feynman maps [ru

  13. Path Integrals in Quantum Mechanics

    International Nuclear Information System (INIS)

    Chetouani, L

    2005-01-01

    By treating path integrals the author, in this book, places at the disposal of the reader a modern tool for the comprehension of standard quantum mechanics. Thus the most important applications, such as the tunnel effect, the diffusion matrix, etc, are presented from an original point of view on the action S of classical mechanics while having it play a central role in quantum mechanics. What also emerges is that the path integral describes these applications more richly than are described traditionally by differential equations, and consequently explains them more fully. The book is certainly of high quality in all aspects: original in presentation, rigorous in the demonstrations, judicious in the choice of exercises and, finally, modern, for example in the treatment of the tunnel effect by the method of instantons. Moreover, the correspondence that exists between classical and quantum mechanics is well underlined. I thus highly recommend this book (the French version being already available) to those who wish to familiarize themselves with formulation by path integrals. They will find, in addition, interesting topics suitable for exploring further. (book review)

  14. Nonperturbative path integral expansion II

    International Nuclear Information System (INIS)

    Kaiser, H.J.

    1976-05-01

    The Feynman path integral representation of the 2-point function for a self-interacting Bose field is investigated using an expansion ('Path Integral Expansion', PIE) of the exponential of the kinetic term of the Lagrangian. This leads to a series - illustrated by a graph scheme - involving successively a coupling of more and more points of the lattice space commonly employed in the evaluation of path integrals. The values of the individual PIE graphs depend of course on the lattice constant. Two methods - Pade approximation and Borel-type extrapolation - are proposed to extract information about the continuum limit from a finite-order PIE. A more flexible PIE is possible by expanding besides the kinetic term a suitably chosen part of the interaction term too. In particular, if the co-expanded part is a mass term the calculation becomes only slightly more complicated than in the original formulation and the appearance of the graph scheme is unchanged. A significant reduction of the number of graphs and an improvement of the convergence of the PIE can be achieved by performing certain sums over an infinity of graph elements. (author)

  15. Distribution definition of path integrals

    International Nuclear Information System (INIS)

    Kerler, W.

    1979-01-01

    By starting from quantum mechanics it turns out that a rather general definition of quantum functional integrals can be given which is based on distribution theory. It applies also to curved space and provides clear rules for non-linear transformations. The refinements necessary in usual definitions of path integrals are pointed out. Since the quantum nature requires special care with time sequences, it is not the classical phase space which occurs in the phase-space form of the path integral. Feynman's configuration-space form only applies to a highly specialized situation, and therefore is not a very advantageous starting point for general investigations. It is shown that the commonly used substitutions of variables do not properly account for quantum effects. The relation to the traditional ordering problem is clarified. The distribution formulation has allowed to treat constrained systems directly at the quantum level, to complete the path integral formulation of the equivalence theorem, and to define functional integrals also for space translation after the transition to fields. (orig.)

  16. Removal of Legacy Low-Level Waste Reactor Moderator De-ionizer Resins Highly Contaminated with Carbon-14 from the 'Waste with no Path to Disposal List' Through Innovative Technical Analysis and Performance Assessment Techniques

    International Nuclear Information System (INIS)

    Goldston, W.T.; Hiergesell, R.A.; Kaplan, D.I.; Pope, H.L.

    2006-01-01

    At the Savannah River Site (SRS), nuclear production reactors used de-ionizers to control the chemistry of the reactor moderator during their operation to produce nuclear materials primarily for the weapons program. These de-ionizers were removed from the reactors and stored as a legacy waste and due to the relatively high carbon-14 (C-14) contamination (i.e., on the order of 740 giga becquerel (GBq) (20 curies) per de-ionizer) were considered a legacy 'waste with no path to disposal'. Considerable progress has been made in consideration of a disposal path for the legacy reactor de-ionizers. Presently, 48 - 50 de-ionizers being stored at SRS have 'no path to disposal' because the disposal limit for C-14 in the SRS's low-level waste disposal facility's Intermediate Level Vault (ILV) is only 160 GBq (4.2 curies) per vault. The current C-14 ILV disposal limit is based on a very conservative analysis of the air pathway. The paper will describe the alternatives that were investigated that resulted in the selection of a route to pursue. This paper will then describe SRS's efforts to reduce the conservatism in the analysis, which resulted in a significantly larger C-14 disposal limit. The work consisted of refining the gas-phase analysis to simulate the migration of C-14 from the waste to the ground surface and evaluated the efficacy of carbonate chemistry in cementitious environment of the ILV for suppressing the volatilization of C-14. During the past year, a Special Analysis was prepared for Department of Energy approval to incorporate the results of these activities that increased the C-14 disposal limits for the ILV, thus allowing for disposal of the Reactor Moderator De-ionizers. Once the Special Analysis is approved by DOE, the actual disposal would be dependent on priority and funding, but the de-ionizers will be removed from the 'waste with no path to disposal list'. (authors)

  17. Cell proliferation of Paramecium tetraurelia under simulated microgravity

    Science.gov (United States)

    Sawai, S.; Mogami, Y.; Baba, S. A.

    Paramecium is known to proliferate faster under microgravity in space and slower under hypergravity Experiments using axenic culture medium have demonstrated that the hypergravity affected directly on the proliferation of Paramecium itself Kato et al 2003 In order to assess the mechanisms underlying the physiological effects of gravity on cell proliferation Paramecium tetraurelia was grown under simulated microgravity performed by clinorotation and the time course of the proliferation was investigated in detail on the basis of the logistic analysis P tetraurelia was cultivated in a closed chamber in which cells were confined without air babbles reducing the shear stresses and turbulence under the rotation The chamber is made of quartz and silicone rubber film the former is for the optically-flat walls for the measurement of cell density by means of a non-invasive laser optical-slice method and the latter for gas exchange Because the closed chamber has an inner dimension of 3 times 3 times 60 mm Paramecium does not accumulate at the top of the chamber despite its negative gravitactic behavior We measured the cell density at regular time intervals without breaking the configuration of the chamber and analyzed the proliferation parameters by fitting the data to a logistic equation Clinorotation had the effects of reducing the proliferation of P tetraurelia It reduced both the saturation cell density and the maximum proliferation rate although it had little effect on the

  18. Future non-proliferation challenges

    International Nuclear Information System (INIS)

    Yelchenko, Volodymyr

    2008-01-01

    Having chaired the Second Session of the Preparatory Committee Mr. Volodymyr Yelchenko noted that the NPT States parties reaffirmed the important role of the Treaty as the cornerstone of the global non-proliferation regime. They stressed that non-compliance with the Treaty provisions by States parties undermined non-proliferation and placed emphasis on the mutually reinforcing nature of disarmament and non-proliferation, and due respect for the right of States parties to the peaceful use of nuclear energy in conformity with the treaty. They reaffirmed the importance of promoting the peaceful uses of nuclear energy and international nuclear cooperation for peaceful purposes in ways consistent with the non-proliferation goal of the Treaty. The universality aspect was brought to the front with the lack of progress in this area. States parties called upon India, Israel and Pakistan to accede to the Treaty as non-nuclear-weapons states, promptly and without conditions and to bring into force comprehensive safeguards agreements, together with Additional Protocols, for ensuring non-proliferation. There is concern that non-States actors could gain access to weapons of mass destruction. One of the underlying themes at the Second Prepcom was the total elimination of nuclear weapons as the only absolute guarantee against their proliferation. Negative consequences to nuclear non-proliferation were also mentioned in the context of the abrogation of the Anti-Ballistic Missile Treaty and the development of missile defense systems, with the risk of a new arms race on Earth and in outer space. The importance of the immediate commencement of negotiations in the Conference of Disarmament on a treaty concerning fissile material for nuclear weapons or other nuclear explosive devices and the urgent conclusion of such a treaty as a beneficial step towards non-proliferation was stressed. The NPT states parties reaffirmed the role of the IAEA as the sole competent authority responsible for

  19. Cooperative path planning of unmanned aerial vehicles

    CERN Document Server

    Tsourdos, Antonios; Shanmugavel, Madhavan

    2010-01-01

    An invaluable addition to the literature on UAV guidance and cooperative control, Cooperative Path Planning of Unmanned Aerial Vehicles is a dedicated, practical guide to computational path planning for UAVs. One of the key issues facing future development of UAVs is path planning: it is vital that swarm UAVs/ MAVs can cooperate together in a coordinated manner, obeying a pre-planned course but able to react to their environment by communicating and cooperating. An optimized path is necessary in order to ensure a UAV completes its mission efficiently, safely, and successfully. Focussing on the path planning of multiple UAVs for simultaneous arrival on target, Cooperative Path Planning of Unmanned Aerial Vehicles also offers coverage of path planners that are applicable to land, sea, or space-borne vehicles. Cooperative Path Planning of Unmanned Aerial Vehicles is authored by leading researchers from Cranfield University and provides an authoritative resource for researchers, academics and engineers working in...

  20. Electron Inelastic-Mean-Free-Path Database

    Science.gov (United States)

    SRD 71 NIST Electron Inelastic-Mean-Free-Path Database (PC database, no charge)   This database provides values of electron inelastic mean free paths (IMFPs) for use in quantitative surface analyses by AES and XPS.

  1. Time optimal paths for high speed maneuvering

    Energy Technology Data Exchange (ETDEWEB)

    Reister, D.B.; Lenhart, S.M.

    1993-01-01

    Recent theoretical results have completely solved the problem of determining the minimum length path for a vehicle with a minimum turning radius moving from an initial configuration to a final configuration. Time optimal paths for a constant speed vehicle are a subset of the minimum length paths. This paper uses the Pontryagin maximum principle to find time optimal paths for a constant speed vehicle. The time optimal paths consist of sequences of axes of circles and straight lines. The maximum principle introduces concepts (dual variables, bang-bang solutions, singular solutions, and transversality conditions) that provide important insight into the nature of the time optimal paths. We explore the properties of the optimal paths and present some experimental results for a mobile robot following an optimal path.

  2. Classical and quantum dynamics from classical paths to path integrals

    CERN Document Server

    Dittrich, Walter

    2016-01-01

    Graduate students who want to become familiar with advanced computational strategies in classical and quantum dynamics will find here both the fundamentals of a standard course and a detailed treatment of the time-dependent oscillator, Chern-Simons mechanics, the Maslov anomaly and the Berry phase, to name a few. Well-chosen and detailed examples illustrate the perturbation theory, canonical transformations, the action principle and demonstrate the usage of path integrals. This new edition has been revised and enlarged with chapters on quantum electrodynamics, high energy physics, Green’s functions and strong interaction.

  3. Path Integral Formulation of Anomalous Diffusion Processes

    OpenAIRE

    Friedrich, Rudolf; Eule, Stephan

    2011-01-01

    We present the path integral formulation of a broad class of generalized diffusion processes. Employing the path integral we derive exact expressions for the path probability densities and joint probability distributions for the class of processes under consideration. We show that Continuous Time Random Walks (CTRWs) are included in our framework. A closed expression for the path probability distribution of CTRWs is found in terms of their waiting time distribution as the solution of a Dyson ...

  4. User requirements and criteria for proliferation resistance in INPRO

    International Nuclear Information System (INIS)

    Choi, K.; Shea, T.E.; Hurt, R.D.; Nishimura, R.

    2004-01-01

    In designing future nuclear energy systems, it is important to consider the potential that such systems could be misused for the purpose of producing nuclear weapons. INPRO set out to provide guidance on incorporating proliferation resistance into innovative nuclear energy systems (INS). Generally two types of proliferation resistance measures are distinguished: intrinsic and extrinsic. Intrinsic features consist of technical design features that reduce the attractiveness of nuclear material for nuclear weapon program, or prevent the diversion of nuclear material or production of undeclared nuclear material for nuclear weapons. Extrinsic measures include commitments, obligations and policies of states such as the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and IAEA safeguards agreements. INPRO has produced five basic principles and five user requirements for INS. It emphasizes that INS must continue to be an unattractive means to acquire fissile material for a nuclear weapon program. It also addresses as user requirements: 1) a balanced and optimised combination of intrinsic features and extrinsic measures, 2) the development and implementation of intrinsic features, 3) an early consideration of proliferation resistance in the development of INS and 4) the utilization of intrinsic features to increase the efficiency of extrinsic measures. INPRO has also developed criteria, consisting of indicators and acceptance limits, which would be used by a state to assess how an INS satisfies those user requirements. For the first user requirement, the most important but complex one, INPRO provides a 3-layer hierarchy of indicators to assess how unattractive a specific INS would be as part of a nuclear weapon program. Attributes of nuclear material and facilities are used as indicators to assess intrinsic features. Extrinsic measures imposed on the system are also assessed. Indicators to assess defence in depth for proliferation resistance include the number and

  5. Data Science in Radiology: A Path Forward.

    Science.gov (United States)

    Aerts, Hugo J W L

    2018-02-01

    Artificial intelligence (AI), especially deep learning, has the potential to fundamentally alter clinical radiology. AI algorithms, which excel in quantifying complex patterns in data, have shown remarkable progress in applications ranging from self-driving cars to speech recognition. The AI application within radiology, known as radiomics, can provide detailed quantifications of the radiographic characteristics of underlying tissues. This information can be used throughout the clinical care path to improve diagnosis and treatment planning, as well as assess treatment response. This tremendous potential for clinical translation has led to a vast increase in the number of research studies being conducted in the field, a number that is expected to rise sharply in the future. Many studies have reported robust and meaningful findings; however, a growing number also suffer from flawed experimental or analytic designs. Such errors could not only result in invalid discoveries, but also may lead others to perpetuate similar flaws in their own work. This perspective article aims to increase awareness of the issue, identify potential reasons why this is happening, and provide a path forward. Clin Cancer Res; 24(3); 532-4. ©2017 AACR . ©2017 American Association for Cancer Research.

  6. Partial Path Column Generation for the ESPPRC

    DEFF Research Database (Denmark)

    Jepsen, Mads Kehlet; Petersen, Bjørn

    This talk introduces a decomposition of the Elementary Shortest Path Problem with Resource Constraints(ESPPRC), where the path is combined by smaller sub paths. We show computational result by comparing different approaches for the decomposition and compare the best of these with existing algorit...

  7. Strain path dependency in metal plasticity

    NARCIS (Netherlands)

    Viatkina, E.M.; Brekelmans, W.A.M.; Geers, M.G.D.

    2003-01-01

    A change in strain path has a significant effect on the mechanical response of metals. Strain path change effects physically originate from a complex microstructure evolution. This paper deals with the contribution of cell structure evolution to the strain path change effect. The material with cells

  8. Cell proliferation of Paramecium tetraurelia on a slow rotating clinostat

    Science.gov (United States)

    Sawai, Satoe; Mogami, Yoshihiro; Baba, Shoji A.

    Paramecium is known to proliferate faster under microgravity conditions, and slower under hypergravity. Experiments using axenic culture medium have demonstrated that hypergravity affected directly on the proliferation of Paramecium itself. In order to assess the mechanisms underlying the physiological effects of gravity on cell proliferation, Paramecium tetraurelia was grown under clinorotation (2.5 rpm) and the time course of the proliferation was investigated in detail on the basis of the logistic analysis. On the basis of the mechanical properties of Paramecium, this slow rate of the rotation appears to be enough to simulate microgravity in terms of the randomization of the cell orientation with respect to gravity. P. tetraurelia was cultivated in a closed chamber in which cells were confined without air bubbles, reducing the shear forces and turbulences under clinorotation. The chamber is made of quartz and silicone rubber film; the former is for the optically-flat walls for the measurement of cell density by means of a non-invasive laser optical-slice method, and the latter for gas exchange. Because of the small dimension for culture space, Paramecium does not accumulate at the top of the chamber in spite of its known negative gravitactic behavior. We measured the cell density at regular time intervals without breaking the configuration of the chamber, and analyzed the proliferation parameters by fitting the data to a logistic equation. As a result, P. tetraurelia showed reduced proliferation under slow clinorotation. The saturation of the cell density as well as the maximum proliferation rate decreased, although we found no significant changes on the half maximal time for proliferation. We also found that the mean swimming velocity decreased under slow clinorotation. These results were not consistent with those under microgravity and fast rotating clinostat. This may suggest that randomization of the cell orientation performed by slow rotating clinostat has

  9. Intermittent pressure decreases human keratinocyte proliferation in vitro.

    Science.gov (United States)

    Nasca, Maria R; Shih, Alan T; West, Dennis P; Martinez, Wanda M; Micali, Giuseppe; Landsman, Adam S

    2007-01-01

    The aim of this study was to investigate the correlation between pressure changes and keratinocyte proliferation by determining whether keratinocytes exposed to altered mechanical pressures would proliferate at different rates compared to control cells not subjected to pressure changes. Tissue culture flasks of human keratinocytes plated at an approximate density of 15,000 cells/cm(2) undergoing an intermittent cyclic pressure of 362 mm Hg at a frequency of 2.28 or 5.16 cycles/min (0.038 or 0.086 Hz) for 8 h were compared to control flasks grown at ambient room pressure. An in-line pressure transducer was used to monitor and adjust pressure within the cell chambers, using a solenoid valve. A thymidine incorporation assay assessed the amount of cell proliferation in each set of experiments. Differences in proliferation between keratinocytes subjected to cyclic pressure changes and control cells were found to be statistically significant (p < 0.05) in 4 out of 5 proliferation assays. Also, a higher frequency of pressure changes consistently generated a reduced proliferation rate compared to that seen in cells exposed to a lower frequency of pressure changes. These data indicate that keratinocytes undergoing intermittent pressure changes exhibit decreased proliferation rates compared to controls. Furthermore, an increased frequency rate seems to have a greater effect on proliferation than low-frequency rate pressure changes, suggesting that the stress caused by frequently changed pressure may play a greater role in reducing keratinocyte proliferation than the actual magnitude of load applied to the cells. Our results support the current treatment protocol of reducing speed and duration of walking on the site of the wound to promote healing of foot ulcers. (c) 2007 S. Karger AG, Basel.

  10. Nuclear proliferation and safeguards. Summary

    International Nuclear Information System (INIS)

    1982-03-01

    This comprehensive analysis of the technological, economic, and political factors affecting the potential spread of nuclear weapons proved useful in the congressional debate which culminated in the Nuclear Non-Proliferation Act of 1978. The report was subsequently published commercially and has been a frequently cited reference in the literature on proliferation and nuclear power. Despite developments since 1977, the information in the OTA report is still useful to those wishing to obtain an indepth understanding of the issues. Included is an analysis of why a nation might want nuclear weapons development program and the various sources of nuclear material are discussed. The control of proliferation is considered as well as its relation to the nuclear industry

  11. Domestic Politics and Nuclear Proliferation

    International Nuclear Information System (INIS)

    Kim, Chul Min; Yim, Man Sung

    2016-01-01

    The external security threat is known as the most important factor of nuclear weapons program, the domestic politics situation can also affect the nuclear proliferation decision of a country. For example, when a leader wants nuclear weapons as an ultimate weapon, the domestic politics situation can determine the effectiveness of the weapons program of a country. This study analyzes the current knowledge of the relationship between domestic politics and nuclear proliferation and suggests the main challenges of the quantitative models trying to calculate nuclear proliferation risk of countries. The domestic politics status is one of the most important indicators of nuclear program. However, some variables have never been used in quantitative analyses; for example, number of veto players and the public opinion on nuclear weapons; despite they are considered to be important in various qualitative studies. Future studies should focus on how should they be coded and how can they be linked with existing domestic politics variables

  12. Domestic Politics and Nuclear Proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chul Min; Yim, Man Sung [KAIST, Daejeon (Korea, Republic of)

    2016-05-15

    The external security threat is known as the most important factor of nuclear weapons program, the domestic politics situation can also affect the nuclear proliferation decision of a country. For example, when a leader wants nuclear weapons as an ultimate weapon, the domestic politics situation can determine the effectiveness of the weapons program of a country. This study analyzes the current knowledge of the relationship between domestic politics and nuclear proliferation and suggests the main challenges of the quantitative models trying to calculate nuclear proliferation risk of countries. The domestic politics status is one of the most important indicators of nuclear program. However, some variables have never been used in quantitative analyses; for example, number of veto players and the public opinion on nuclear weapons; despite they are considered to be important in various qualitative studies. Future studies should focus on how should they be coded and how can they be linked with existing domestic politics variables.

  13. Space charge models and PATH

    International Nuclear Information System (INIS)

    Wald, H.B.

    1990-01-01

    The 'PATH' codes are used to design magnetic optics subsystems for neutral particle beam systems. They include a 2-1/2D and three 3-D space charge models, two of which have recently been added. This paper describes the 3-D models and reports on preliminary benchmark studies in which these models are checked for stability as the cloud size is varied and for consistency with each other. Differences between the models are investigated and the computer time requirements for running these models are established

  14. Innovation paths in wind power

    DEFF Research Database (Denmark)

    Lema, Rasmus; Nordensvärd, Johan; Urban, Frauke

    Denmark and Germany both make substantial investments in low carbon innovation, not least in the wind power sector. These investments in wind energy are driven by the twin objectives of reducing carbon emissions and building up international competitive advantage. Support for wind power dates back....... The ‘Danish Design’ remains the global standard. The direct drive design, while uncommon in Denmark, dominates the German installation base. Direct drive technology has thus emerged as a distinctly German design and sub-trajectory within the overall technological innovation path. When it comes to organising...... global interconnectedness of wind technology markets and the role of emerging new players, such as China and India....

  15. Uncommon paths in quantum physics

    CERN Document Server

    Kazakov, Konstantin V

    2014-01-01

    Quantum mechanics is one of the most fascinating, and at the same time most controversial, branches of contemporary science. Disputes have accompanied this science since its birth and have not ceased to this day. Uncommon Paths in Quantum Physics allows the reader to contemplate deeply some ideas and methods that are seldom met in the contemporary literature. Instead of widespread recipes of mathematical physics, based on the solutions of integro-differential equations, the book follows logical and partly intuitional derivations of non-commutative algebra. Readers can directly penetrate the

  16. Ultracentrifuge and non-proliferation

    International Nuclear Information System (INIS)

    Voortman, A.J.

    1977-01-01

    The author states that there is no meaningful difference, from the point of view of proliferation between peaceful, civil, scientific application of nuclear fission, and the use of it in nuclear weapons. The proliferation of the nuclear technology for weapons appeared and appears to be closely connected with the spread of peaceful applications of nuclear technology. In connection with this, he discusses the Ultracentrifuge plant at Almelo (Netherlands) and the supply of nuclear technology by West-Germany especially to Brazil. Further the changed American policy and the possibility of an American/Russian deal to prevent the spread of the nuclear enrichment technology is discussed

  17. Fundamental changes to EPA's research enterprise: the path forward.

    Science.gov (United States)

    Anastas, Paul T

    2012-01-17

    Environmental protection in the United States has reached a critical juncture. It has become clear that to address the complex and interrelated environmental challenges we face, we must augment our traditional approaches. The scientific community must build upon its deep understanding of risk assessment, risk management, and reductionism with tools, technologies, insights and approaches to pursue sustainability. The U.S. Environmental Protection Agency (EPA) has recognized this need for systemic change by implementing a new research paradigm called "The Path Forward." This paper outlines the principles of the Path Forward and the actions taken since 2010 to align EPA's research efforts with the goal of sustainability.

  18. Simulation of car movement along circular path

    Science.gov (United States)

    Fedotov, A. I.; Tikhov-Tinnikov, D. A.; Ovchinnikova, N. I.; Lysenko, A. V.

    2017-10-01

    Under operating conditions, suspension system performance changes which negatively affects vehicle stability and handling. The paper aims to simulate the impact of changes in suspension system performance on vehicle stability and handling. Methods. The paper describes monitoring of suspension system performance, testing of vehicle stability and handling, analyzes methods of suspension system performance monitoring under operating conditions. The mathematical model of a car movement along a circular path was developed. Mathematical tools describing a circular movement of a vehicle along a horizontal road were developed. Turning car movements were simulated. Calculation and experiment results were compared. Simulation proves the applicability of a mathematical model for assessment of the impact of suspension system performance on vehicle stability and handling.

  19. Welding Robot Collision-Free Path Optimization

    Directory of Open Access Journals (Sweden)

    Xuewu Wang

    2017-02-01

    Full Text Available Reasonable welding path has a significant impact on welding efficiency, and a collision-free path should be considered first in the process of welding robot path planning. The shortest path length is considered as an optimization objective, and obstacle avoidance is considered as the constraint condition in this paper. First, a grid method is used as a modeling method after the optimization objective is analyzed. For local collision-free path planning, an ant colony algorithm is selected as the search strategy. Then, to overcome the shortcomings of the ant colony algorithm, a secondary optimization is presented to improve the optimization performance. Finally, the particle swarm optimization algorithm is used to realize global path planning. Simulation results show that the desired welding path can be obtained based on the optimization strategy.

  20. Integral transforms of the quantum mechanical path integral: Hit function and path-averaged potential

    Science.gov (United States)

    Edwards, James P.; Gerber, Urs; Schubert, Christian; Trejo, Maria Anabel; Weber, Axel

    2018-04-01

    We introduce two integral transforms of the quantum mechanical transition kernel that represent physical information about the path integral. These transforms can be interpreted as probability distributions on particle trajectories measuring respectively the relative contribution to the path integral from paths crossing a given spatial point (the hit function) and the likelihood of values of the line integral of the potential along a path in the ensemble (the path-averaged potential).

  1. Classical and quantum dynamics from classical paths to path integrals

    CERN Document Server

    Dittrich, Walter

    2017-01-01

    Graduate students who wish to become familiar with advanced computational strategies in classical and quantum dynamics will find in this book both the fundamentals of a standard course and a detailed treatment of the time-dependent oscillator, Chern-Simons mechanics, the Maslov anomaly and the Berry phase, to name just a few topics. Well-chosen and detailed examples illustrate perturbation theory, canonical transformations and the action principle, and demonstrate the usage of path integrals. The fifth edition has been revised and enlarged to include chapters on quantum electrodynamics, in particular, Schwinger’s proper time method and the treatment of classical and quantum mechanics with Lie brackets and pseudocanonical transformations. It is shown that operator quantum electrodynamics can be equivalently described with c-numbers, as demonstrated by calculating the propagation function for an electron in a prescribed classical electromagnetic field.

  2. Proliferating macrophages prevail in atherosclerosis.

    Science.gov (United States)

    Randolph, Gwendalyn J

    2013-09-01

    Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes.

  3. Irradiation response of rapidly solidified Path A type prime candidate alloys

    International Nuclear Information System (INIS)

    Imeson, E.; Tong, C.; Lee, M.; Vander Sande, J.B.; Harling, O.K.

    1981-01-01

    The objective of this study is to present a first assessment of the microstructural response to neutron irradiation shown by Path A alloys prepared by rapid solidification processing. To more fully demonstrate the potential of the method, alloys with increased titanium and carbon content have been used in addition to the Path A prime candidate alloy

  4. Integrated assignment and path planning

    Science.gov (United States)

    Murphey, Robert A.

    2005-11-01

    A surge of interest in unmanned systems has exposed many new and challenging research problems across many fields of engineering and mathematics. These systems have the potential of transforming our society by replacing dangerous and dirty jobs with networks of moving machines. This vision is fundamentally separate from the modern view of robotics in that sophisticated behavior is realizable not by increasing individual vehicle complexity, but instead through collaborative teaming that relies on collective perception, abstraction, decision making, and manipulation. Obvious examples where collective robotics will make an impact include planetary exploration, space structure assembly, remote and undersea mining, hazardous material handling and clean-up, and search and rescue. Nonetheless, the phenomenon driving this technology trend is the increasing reliance of the US military on unmanned vehicles, specifically, aircraft. Only a few years ago, following years of resistance to the use of unmanned systems, the military and civilian leadership in the United States reversed itself and have recently demonstrated surprisingly broad acceptance of increasingly pervasive use of unmanned platforms in defense surveillance, and even attack. However, as rapidly as unmanned systems have gained acceptance, the defense research community has discovered the technical pitfalls that lie ahead, especially for operating collective groups of unmanned platforms. A great deal of talent and energy has been devoted to solving these technical problems, which tend to fall into two categories: resource allocation of vehicles to objectives, and path planning of vehicle trajectories. An extensive amount of research has been conducted in each direction, yet, surprisingly, very little work has considered the integrated problem of assignment and path planning. This dissertation presents a framework for studying integrated assignment and path planning and then moves on to suggest an exact

  5. The Path to Deep Nuclear Reductions. Dealing with American Conventional Superiority

    Energy Technology Data Exchange (ETDEWEB)

    Gormley, D.M.

    2009-07-01

    The transformation of the U.S. conventional capabilities has begun to have a substantial and important impact on counter-force strike missions particularly as they affect counter-proliferation requirements. So too have improvements in ballistic missile defense programs, which are also critically central to U.S. counter-proliferation objectives. These improved conventional capabilities come at a time when thinking about the prospects of eventually achieving a nuclear disarmed world has never been so promising. Yet, the path toward achieving that goal, or making substantial progress towards it, is fraught with pitfalls, including domestic political, foreign, and military ones. Two of the most important impediments to deep reductions in U.S. and Russian nuclear arsenals - no less a nuclear disarmed world - are perceived U.S. advantages in conventional counter-force strike capabilities working in combination with even imperfect but growing missile defense systems. The Barack Obama administration has already toned down the George W. Bush administration's rhetoric surrounding many of these new capabilities. Nevertheless, it is likely to affirm that it is a worthy goal to pursue a more conventionally oriented denial strategy as America further weans itself from its reliance on nuclear weapons. The challenge is to do so in the context of a more multilateral or collective security environment in which transparency plays the role it once did during the Cold War as a necessary adjunct to arms control agreements. Considerable thought has already been devoted to assessing many of the challenges along the way to a nuclear-free world, including verifying arsenals when they reach very low levels, more effective management of the civilian nuclear programs that remain, enforcement procedures, and what, if anything, might be needed to deal with latent capacities to produce nuclear weapons.1 But far less thought has been expended on why Russia - whose cooperation is absolutely

  6. The Path to Deep Nuclear Reductions. Dealing with American Conventional Superiority

    International Nuclear Information System (INIS)

    Gormley, D.M.

    2009-01-01

    The transformation of the U.S. conventional capabilities has begun to have a substantial and important impact on counter-force strike missions particularly as they affect counter-proliferation requirements. So too have improvements in ballistic missile defense programs, which are also critically central to U.S. counter-proliferation objectives. These improved conventional capabilities come at a time when thinking about the prospects of eventually achieving a nuclear disarmed world has never been so promising. Yet, the path toward achieving that goal, or making substantial progress towards it, is fraught with pitfalls, including domestic political, foreign, and military ones. Two of the most important impediments to deep reductions in U.S. and Russian nuclear arsenals - no less a nuclear disarmed world - are perceived U.S. advantages in conventional counter-force strike capabilities working in combination with even imperfect but growing missile defense systems. The Barack Obama administration has already toned down the George W. Bush administration's rhetoric surrounding many of these new capabilities. Nevertheless, it is likely to affirm that it is a worthy goal to pursue a more conventionally oriented denial strategy as America further weans itself from its reliance on nuclear weapons. The challenge is to do so in the context of a more multilateral or collective security environment in which transparency plays the role it once did during the Cold War as a necessary adjunct to arms control agreements. Considerable thought has already been devoted to assessing many of the challenges along the way to a nuclear-free world, including verifying arsenals when they reach very low levels, more effective management of the civilian nuclear programs that remain, enforcement procedures, and what, if anything, might be needed to deal with latent capacities to produce nuclear weapons.1 But far less thought has been expended on why Russia - whose cooperation is absolutely

  7. Model for nuclear proliferation resistance analysis using decision making tools

    International Nuclear Information System (INIS)

    Ko, Won Il; Kim, Ho Dong; Yang, Myung Seung

    2003-06-01

    The nuclear proliferation risks of nuclear fuel cycles is being considered as one of the most important factors in assessing advanced and innovative nuclear systems in GEN IV and INPRO program. They have been trying to find out an appropriate and reasonable method to evaluate quantitatively several nuclear energy system alternatives. Any reasonable methodology for integrated analysis of the proliferation resistance, however, has not yet been come out at this time. In this study, several decision making methods, which have been used in the situation of multiple objectives, are described in order to see if those can be appropriately used for proliferation resistance evaluation. Especially, the AHP model for quantitatively evaluating proliferation resistance is dealt with in more detail. The theoretical principle of the method and some examples for the proliferation resistance problem are described. For more efficient applications, a simple computer program for the AHP model is developed, and the usage of the program is introduced here in detail. We hope that the program developed in this study could be useful for quantitative analysis of the proliferation resistance involving multiple conflict criteria

  8. Model for nuclear proliferation resistance analysis using decision making tools

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Won Il; Kim, Ho Dong; Yang, Myung Seung

    2003-06-01

    The nuclear proliferation risks of nuclear fuel cycles is being considered as one of the most important factors in assessing advanced and innovative nuclear systems in GEN IV and INPRO program. They have been trying to find out an appropriate and reasonable method to evaluate quantitatively several nuclear energy system alternatives. Any reasonable methodology for integrated analysis of the proliferation resistance, however, has not yet been come out at this time. In this study, several decision making methods, which have been used in the situation of multiple objectives, are described in order to see if those can be appropriately used for proliferation resistance evaluation. Especially, the AHP model for quantitatively evaluating proliferation resistance is dealt with in more detail. The theoretical principle of the method and some examples for the proliferation resistance problem are described. For more efficient applications, a simple computer program for the AHP model is developed, and the usage of the program is introduced here in detail. We hope that the program developed in this study could be useful for quantitative analysis of the proliferation resistance involving multiple conflict criteria.

  9. Path Creation, Path Dependence and Breaking Away from the Path: Re-Examining the Case of Nokia

    OpenAIRE

    Wang, Jens; Hedman, Jonas; Tuunainen, Virpi Kristiina

    2016-01-01

    The explanation of how and why firms succeed or fail is a recurrent research challenge. This is particularly important in the context of technological innovations. We focus on the role of historical events and decisions in explaining such success and failure. Using a case study of Nokia, we develop and extend a multi-layer path dependence framework. We identify four layers of path dependence: technical, strategic and leadership, organizational, and external collaboration. We show how path dep...

  10. Rainbow paths with prescribed ends

    DEFF Research Database (Denmark)

    Alishahi, Meysam; Taherkhani, Ali; Thomassen, Carsten

    2011-01-01

    vertices. We also prove that every connected graph with atleast one edge has a proper k-coloring (for some k) such that every vertex of color i has a neighbor of color i + 1 (mod k). C-5 shows that k may have to be greater than the chromatic number. However, if the graph is connected, infinite and locally...... finite, and has finite chromatic number, then the k-coloring exists for every k >= chi(G). In fact, the k-coloring can be chosen such that every vertex is a starting vertex of an infinite path such that the color increases by 1 (mod k) along each edge. The method is based on the circular chromatic number...... chi(c)(G). In particular, we verify the above conjecture for all connected graphs whose circular chromatic number equals the chromatic number....

  11. Counting paths with Schur transitions

    Energy Technology Data Exchange (ETDEWEB)

    Díaz, Pablo [Department of Physics and Astronomy, University of Lethbridge, Lethbridge, Alberta, T1K 3M4 (Canada); Kemp, Garreth [Department of Physics, University of Johannesburg, P.O. Box 524, Auckland Park 2006 (South Africa); Véliz-Osorio, Alvaro, E-mail: aveliz@gmail.com [Mandelstam Institute for Theoretical Physics, University of the Witwatersrand, WITS 2050, Johannesburg (South Africa); School of Physics and Astronomy, Queen Mary, University of London, Mile End Road, London E1 4NS (United Kingdom)

    2016-10-15

    In this work we explore the structure of the branching graph of the unitary group using Schur transitions. We find that these transitions suggest a new combinatorial expression for counting paths in the branching graph. This formula, which is valid for any rank of the unitary group, reproduces known asymptotic results. We proceed to establish the general validity of this expression by a formal proof. The form of this equation strongly hints towards a quantum generalization. Thus, we introduce a notion of quantum relative dimension and subject it to the appropriate consistency tests. This new quantity finds its natural environment in the context of RCFTs and fractional statistics; where the already established notion of quantum dimension has proven to be of great physical importance.

  12. Status of Methodology Development for the Evaluation of Proliferation Resistance

    International Nuclear Information System (INIS)

    Lee, Yong Deok; Ko, Won Il; Lee, Jung Won

    2010-01-01

    Concerning the increasing energy demand and green house effect, nuclear energy is now the most feasible option. Therefore, recently, oil countries even have a plan to build the nuclear power plant for energy production. If nuclear systems are to make a major and sustainable contribution to the worlds energy supply, future nuclear energy systems must meet specific requirements. One of the requirements is to satisfy the proliferation resistance condition in an entire nuclear system. Therefore, from the beginning of future nuclear energy system development, it is important to consider a proliferation resistance to prevent the diversion of nuclear materials. The misuse of a nuclear system must be considered as well. Moreover, in the import and export of nuclear system, the evaluation of the proliferation resistance on the nuclear system becomes a key factor The INPRO (International Project on Innovative Nuclear Reactors and Fuel Cycles) program initiated by the IAEA proposed proliferation resistance (PR) as a key component of a future innovative nuclear system (INS) with a sustainability, economics, safety of nuclear installation and waste management. The technical goal for Generation IV (Gen IV) nuclear energy systems (NESs) highlights a Proliferation Resistance and Physical Protection (PR and PP), sustainability, safety, reliability and economics as well. Based on INPRO and Gen IV study, the methodology development for the evaluation of proliferation resistance has been carried out in KAERI. Finally, the systematic procedure for methodology was setup and the indicators for the procedure were decided. The methodology involves the evaluation from total nuclear system to individual process. Therefore, in this study, the detailed procedure for the evaluation of proliferation resistance and the newly proposed additional indicators are described and several conditions are proposed to increase the proliferation resistance in the future nuclear system. The assessment of PR

  13. Strategic Team AI Path Plans: Probabilistic Pathfinding

    Directory of Open Access Journals (Sweden)

    Tng C. H. John

    2008-01-01

    Full Text Available This paper proposes a novel method to generate strategic team AI pathfinding plans for computer games and simulations using probabilistic pathfinding. This method is inspired by genetic algorithms (Russell and Norvig, 2002, in that, a fitness function is used to test the quality of the path plans. The method generates high-quality path plans by eliminating the low-quality ones. The path plans are generated by probabilistic pathfinding, and the elimination is done by a fitness test of the path plans. This path plan generation method has the ability to generate variation or different high-quality paths, which is desired for games to increase replay values. This work is an extension of our earlier work on team AI: probabilistic pathfinding (John et al., 2006. We explore ways to combine probabilistic pathfinding and genetic algorithm to create a new method to generate strategic team AI pathfinding plans.

  14. Tool path in torus tool CNC machining

    Directory of Open Access Journals (Sweden)

    XU Ying

    2016-10-01

    Full Text Available This paper is about tool path in torus tool CNC machining.The mathematical model of torus tool is established.The tool path planning algorithm is determined through calculation of the cutter location,boundary discretization,calculation of adjacent tool path and so on,according to the conversion formula,the cutter contact point will be converted to the cutter location point and then these points fit a toolpath.Lastly,the path planning algorithm is implemented by using Matlab programming.The cutter location points for torus tool are calculated by Matlab,and then fit these points to a toolpath.While using UG software,another tool path of free surface is simulated of the same data.It is drew compared the two tool paths that using torus tool is more efficient.

  15. Nuclear energy and proliferation: A longer perspective

    International Nuclear Information System (INIS)

    Weinberg, A.M.

    1985-01-01

    Nuclear power has expanded slowly; and it is largely based on reactors that require no recycle. The original basis for concern about proliferation - that nuclear power would be used very widely and that it would be based on systems that required reprocessing - has been shaken. The present world nuclear energy system, which is small and based on no-recycle reactors, is relatively resistant to proliferation via diversion from power reactors. Though worry about proliferation can never be eliminated, the perceived connection between power and bombs can be slowly reduced. The proposal to link fuel take-back with waste disposal poses a dilemma for the ''nuclear environmental'' activists. This group objects to nuclear power because, in their view, reactor wastes threaten the environment, and because bombs and reactors are connected. Both objections are held, often passionately; it would be difficult to assess which takes primacy. This proposal further breaks the ''Nuclear Connection,'' but at the expense of adding a little to the volume of wastes the United States would have to dispose of. We are in effect saying that the loosening of the nuclear connection through the take-back scheme should take precedence over the tiny environmental burden incurred by the addition of a few percent to the total wastes the U.S. already must dispose of. It is hoped that the nuclear environmental community will recognize this trade-off, and will help create the atmosphere of public understanding necessary if fuel take-back is to be accepted in the United States

  16. Design of Active N-path Filters

    NARCIS (Netherlands)

    Darvishi, M.; van der Zee, Ronan A.R.; Nauta, Bram

    2013-01-01

    A design methodology for synthesis of active N-path bandpass filters is introduced. Based on this methodology, a 0.1-to-1.2 GHz tunable 6th-order N-path channel-select filter in 65 nm LP CMOS is introduced. It is based on coupling N-path filters with gyrators, achieving a “flat‿ passband shape and

  17. Non proliferation of nuclear weapons?

    International Nuclear Information System (INIS)

    Le Guelte, Georges

    2015-10-01

    After having evoked the behaviour of nuclear countries regarding the development of nuclear weapons and uranium procurement, or nuclear programmes after the Second World War until nowadays, the author presents the non proliferation Treaty (NPT) as a construction at the service of super-powers. He comments and discusses the role of the IAEA control system and its evolutions: a control limited to declared installations, an export control with the spectre of plutonium, a control system thwarted by some technological innovations, information systems coming in, and an additional protocol related to the application of guarantees. He comments the evolution of the context from a bipolar world to a world without pole which raises the issue of how to have commitments respected: description of the role and practice of non proliferation during the Cold War, after the Cold War, and in a world without governance

  18. Status of the Gen-IV Proliferation Resistance and Physical Protection (PRPP) Evaluation Methodology

    International Nuclear Information System (INIS)

    Whitlock, J.; Bari, R.; Peterson, P.; Padoani, F.; Cojazzi, G.G.M.; Renda, G.; ); Cazalet, J.; Haas, E.; Hori, K.; Kawakubo, Y.; Chang, S.; Kim, H.; Kwon, E.-H.; Yoo, H.; Chebeskov, A.; Pshakin, G.; Pilat, J.F.; Therios, I.; Bertel, E.

    2015-01-01

    Methodologies have been developed within the Generation IV International Forum (GIF) to support the assessment and improvement of system performance in the areas safeguards, security, economics and safety. Of these four areas, safeguards and security are the subjects of the GIF working group on Proliferation Resistance and Physical Protection (PRPP). Since the PRPP methodology (now at Revision 6) represents a mature, generic, and comprehensive evaluation approach, and is freely available on the GIF public website, several non-GIF technical groups have chosen to utilize the PRPP methodology for their own goals. Indeed, the results of the evaluations performed with the methodology are intended for three types of generic users: system designers, programme policy makers, and external stakeholders. The PRPP Working Group developed the methodology through a series of demonstration and case studies. In addition, over the past few years various national and international groups have applied the methodology to inform nuclear energy system designs, as well as to support the development of approaches to advanced safeguards. A number of international workshops have also been held which have introduced the methodology to design groups and other stakeholders. In this paper we summarize the technical progress and accomplishments of the PRPP evaluation methodology, including applications outside GIF, and we outline the PRPP methodology's relationship with the IAEA's INPRO methodology. Current challenges with the efficient implementation of the methodology are outlined, along with our path forward for increasing its accessibility to a broader stakeholder audience - including supporting the next generation of skilled professionals in the nuclear non-proliferation field. (author)

  19. Nuclear power and weapons proliferation

    International Nuclear Information System (INIS)

    Greenwood, T.; Rathjens, C.W.; Ruina, J.

    1977-01-01

    The relationship between nuclear weapons development and nuclear electric power is examined. A brief description of nuclear weapons design is first given. This is then followed by a discussion of various aspects of nuclear power technology and of how they affect a nuclear weapon programme. These include fuel cycles, chemical reprocessing of spent fuel, uranium enrichment, and the control of dissemination of nuclear technology. In conclusion there is a discussion of possible political and institutional controls for limiting nuclear proliferation. (U.K.)

  20. CBRN and proliferation in Asia

    International Nuclear Information System (INIS)

    Brisset, Jean-Vincent

    2015-01-01

    The author proposes a brief overview of the history, evolution and status of military nuclear weapons and programmes as well as bacteriologic and chemical weapons (nuclear weapons, ballistic missile, and position with respect with the Conventions on chemical and bacteriologic weapons) in Asian countries (China, Japan, India, Pakistan, North Korea). In a second part, he discusses issues related to exports and possible proliferation from these countries

  1. Path integrals and geometry of trajectories

    International Nuclear Information System (INIS)

    Blau, M.; Keski-Vakkuri, E.; Niemi, A.J.

    1990-01-01

    A geometrical interpretation of path integrals is developed in the space of trajectories. This yields a supersymmetric formulation of a generic path integral, with the supersymmetry resembling the BRST supersymmetry of a first class constrained system. If the classical equation of motion is a Killing vector field in the space of trajectories, the supersymmetry localizes the path integral to classical trajectories and the WKB approximation becomes exact. This can be viewed as a path integral generalization of the Duistermaat-Heckman theorem, which states the conditions for the exactness of the WKB approximation for integrals in a compact phase space. (orig.)

  2. Path integrals for arbitrary canonical transformations

    International Nuclear Information System (INIS)

    Oliveira, L.A.R. de.

    1980-01-01

    Some aspects of the path integral formulation of quantum mechanics are studied. This formalism is generalized to arbitrary canonical transformations, by means of an association between path integral probalility amplitudes and classical generators of transformations, analogous to the usual Hamiltonian time development phase space expression. Such association turns out to be equivalent to the Weyl quantization rule, and it is also shown that this formalism furnishes a path integral representation for a Lie algebra of a given set of classical generators. Some physical considerations about the path integral quantization procedure and about the relationship between classical and quantum dynamical structures are also discussed. (Author) [pt

  3. Techniques and applications of path integration

    CERN Document Server

    Schulman, L S

    2005-01-01

    A book of techniques and applications, this text defines the path integral and illustrates its uses by example. It is suitable for advanced undergraduates and graduate students in physics; its sole prerequisite is a first course in quantum mechanics. For applications requiring specialized knowledge, the author supplies background material.The first part of the book develops the techniques of path integration. Topics include probability amplitudes for paths and the correspondence limit for the path integral; vector potentials; the Ito integral and gauge transformations; free particle and quadra

  4. Symbolic PathFinder v7

    DEFF Research Database (Denmark)

    Luckow, Kasper Søe; Păsăreanu, Corina

    2014-01-01

    We describe Symbolic PathFinder v7 in terms of its updated design addressing the changes of Java PathFinder v7 and of its new optimization when computing path conditions. Furthermore, we describe the Symbolic Execution Tree Extension; a newly added feature that allows for outputting the symbolic...... execution tree that characterizes the execution paths covered during symbolic execution. The new extension can be tailored to the needs of subsequent analyses/processing facilities, and we demonstrate this by presenting SPF-Visualizer, which is a tool for customizable visualization of the symbolic execution...

  5. Kinetic constrained optimization of the golf swing hub path.

    Science.gov (United States)

    Nesbit, Steven M; McGinnis, Ryan S

    2014-12-01

    This study details an optimization of the golf swing, where the hand path and club angular trajectories are manipulated. The optimization goal was to maximize club head velocity at impact within the interaction kinetic limitations (force, torque, work, and power) of the golfer as determined through the analysis of a typical swing using a two-dimensional dynamic model. The study was applied to four subjects with diverse swing capabilities and styles. It was determined that it is possible for all subjects to increase their club head velocity at impact within their respective kinetic limitations through combined modifications to their respective hand path and club angular trajectories. The manner of the modifications, the degree of velocity improvement, the amount of kinetic reduction, and the associated kinetic limitation quantities were subject dependent. By artificially minimizing selected kinetic inputs within the optimization algorithm, it was possible to identify swing trajectory characteristics that indicated relative kinetic weaknesses of a subject. Practical implications are offered based upon the findings of the study. Key PointsThe hand path trajectory is an important characteristic of the golf swing and greatly affects club head velocity and golfer/club energy transfer.It is possible to increase the energy transfer from the golfer to the club by modifying the hand path and swing trajectories without increasing the kinetic output demands on the golfer.It is possible to identify relative kinetic output strengths and weakness of a golfer through assessment of the hand path and swing trajectories.Increasing any one of the kinetic outputs of the golfer can potentially increase the club head velocity at impact.The hand path trajectory has important influences over the club swing trajectory.

  6. Neural control of colonic cell proliferation.

    Science.gov (United States)

    Tutton, P J; Barkla, D H

    1980-03-15

    The mitotic rate in rat colonic crypts and in dimethylhydrazine-induced colonic carcinomas was measured using a stathmokinetic technique. In sympathectomized animals cell proliferation was retarded in the crypts but not in the tumors, whereas in animals treated with Metaraminol, a drug which releases norepinephrine from nerve terminals, crypt cell but not tumor cell proliferation was accelerated. Blockade of alpha-adrenoceptors also inhibited crypt cell proliferation. However, stimulation of beta-adrenoceptors inhibited and blockade of beta-adrenoceptors accelerated tumor cell proliferation without influencing crypt cell proliferation. Injection of either serotonin or histamine stimulated tumor but not crypt cell proliferation and blockade or serotonin receptors or histamine H2-receptors inhibited tumor cell proliferation. It is postulated that cell proliferation in the colonic crypts, like that in the jejunal crypts, is under both endocrine and autonomic neural control whereas colonic tumor cell division is subject to endocrine regulation alone.

  7. Polyamines and post-irradiation cell proliferation

    International Nuclear Information System (INIS)

    Rosiek, O.; Wronowski, T.; Lerozak, K.; Kopec, M.

    1978-01-01

    The results of three sets of experiments will be presented. Firstly polyamines and DNA content was determined in bone marrow, mesenteric lymph nodes, spleen, liver and kidney of rabbits at the 1, 5, 10 and 20th day after exposure to 600 R of X-irradiation. Polyamine concentration in bone marrow, spleen and lymph nodes was found to be markedly increased during the period of postirradiation recovery. Secondly, effect of 10 -5 M methyl glyoxalbis, guanylhydrazone (MGBG), an inhibitor of spermidine and spermine synthesis, on multiplication of X-irradiated cultures of murine lymphoblaste L5178Y-S was assessed. MGBG-induced inhibition of cell proliferation could be prevented by concurrent administration of 10 -4 M spermidine. Thirdly the influence of putrescine on bone marrow cellularity and 3 H-thymidine incorporation into bone marrow cells was investigated in X-irradiated mice. The results obtained indicate close relation of polyamines to cell proliferation processes after irradiation. (orig./AJ) [de

  8. Non-proliferation of nuclear weapons

    International Nuclear Information System (INIS)

    Fischer, D.; Haeckel, E.; Haefele, W.; Lauppe, W.D.; Mueller, H.; Ungerer, W.

    1991-01-01

    During the turbulant transitional events in world politics in the nineties, the control of nuclear weapons plays a major role. While the superpowers are reducing their nuclear arsenal, the danger of nuclear anarchy in the world remains virulent. The NPT of 1968 is up for review soon. The falling apart of the former communist sphere of power, and the regions of conflict in the Third World present new risks for the proliferation of nuclear arms. For unified Germany, which explicitly renounced nuclear weapons, this situation presents difficult questions concerning national safety policies and international responsibility. This volume presents contributions which take a new look at topical and long-term problems of nuclear NP politics. The authors evaluate the conditions under which the NP regime came into being, and assess short- and long-term possibilities and risks. The following papers are included: 1.) Basic controversies during the negotiations concerning the Treaty on non-proliferation of nuclear weapons (Ungerer); 2.) Prologation of the NPT 1995 and appropriate problems concerning safety and control (Haefele/Lauppe); 3.) Consequences of the Iraq case for NP policy (Ficher); 4.) Problems of nuclear technology control (Mueller); 5.) Framework conditions of a nuclear world system (Haeckel). (orig./HP) [de

  9. Joint modeling of constrained path enumeration and path choice behavior: a semi-compensatory approach

    DEFF Research Database (Denmark)

    Kaplan, Sigal; Prato, Carlo Giacomo

    2010-01-01

    A behavioural and a modelling framework are proposed for representing route choice from a path set that satisfies travellers’ spatiotemporal constraints. Within the proposed framework, travellers’ master sets are constructed by path generation, consideration sets are delimited according to spatio...

  10. Hierarchical path planning and control of a small fixed-wing UAV: Theory and experimental validation

    Science.gov (United States)

    Jung, Dongwon

    2007-12-01

    Recently there has been a tremendous growth of research emphasizing control of unmanned aerial vehicles (UAVs) either in isolation or in teams. As a matter of fact, UAVs increasingly find their way into military and law enforcement applications (e.g., reconnaissance, remote delivery of urgent equipment/material, resource assessment, environmental monitoring, battlefield monitoring, ordnance delivery, etc.). This trend will continue in the future, as UAVs are poised to replace the human-in-the-loop during dangerous missions. Civilian applications of UAVs are also envisioned such as crop dusting, geological surveying, search and rescue operations, etc. In this thesis we propose a new online multiresolution path planning algorithm for a small UAV with limited on-board computational resources. The proposed approach assumes that the UAV has detailed information of the environment and the obstacles only in its vicinity. Information about far-away obstacles is also available, albeit less accurately. The proposed algorithm uses the fast lifting wavelet transform (FLWT) to get a multiresolution cell decomposition of the environment, whose dimension is commensurate to the on-board computational resources. A topological graph representation of the multiresolution cell decomposition is constructed efficiently, directly from the approximation and detail wavelet coefficients. Dynamic path planning is sequentially executed for an optimal path using the A* algorithm over the resulting graph. The proposed path planning algorithm is implemented on-line on a small autopilot. Comparisons with the standard D*-lite algorithm are also presented. We also investigate the problem of generating a smooth, planar reference path from a discrete optimal path. Upon the optimal path being represented as a sequence of cells in square geometry, we derive a smooth B-spline path that is constrained inside a channel that is induced by the geometry of the cells. To this end, a constrained optimization

  11. Decision paths in complex tasks

    Science.gov (United States)

    Galanter, Eugene

    1991-01-01

    Complex real world action and its prediction and control has escaped analysis by the classical methods of psychological research. The reason is that psychologists have no procedures to parse complex tasks into their constituents. Where such a division can be made, based say on expert judgment, there is no natural scale to measure the positive or negative values of the components. Even if we could assign numbers to task parts, we lack rules i.e., a theory, to combine them into a total task representation. We compare here two plausible theories for the amalgamation of the value of task components. Both of these theories require a numerical representation of motivation, for motivation is the primary variable that guides choice and action in well-learned tasks. We address this problem of motivational quantification and performance prediction by developing psychophysical scales of the desireability or aversiveness of task components based on utility scaling methods (Galanter 1990). We modify methods used originally to scale sensory magnitudes (Stevens and Galanter 1957), and that have been applied recently to the measure of task 'workload' by Gopher and Braune (1984). Our modification uses utility comparison scaling techniques which avoid the unnecessary assumptions made by Gopher and Braune. Formula for the utility of complex tasks based on the theoretical models are used to predict decision and choice of alternate paths to the same goal.

  12. Inked Careers: Tattooing Professional Paths

    Directory of Open Access Journals (Sweden)

    Gabriela DeLuca

    2016-12-01

    Full Text Available The concept of career has an interdisciplinary and historical constitution, which includes persons, groups, organizations and society. Given that, we aim to deepen the interactionist notion of career from the understanding of a deviant path, supported by a theory and a method appropriated to the cited call for interdisciplinary approaches. Dilemmas (Hughes, 1958 and conflicts (Hughes, 1937 emerged as important analytical categories. Although necessary, these two concepts were not sufficient to contemplate analyses in their entirety. For this reason we conceptualized a third possibility of controversy during a career: the inquiries. The study followed the Narrative method to analyze objective and subjective changes during a tattoo artist’s career through interviews and informal conversations carried out over 22 months. The discussion presents three main contributions. Theoretically, a new understanding of the concept of careers, linking past, present and future and the idea of non-linearity of experienced and envisioned careers. Methodologically, suggesting orientations for future career studies such as the use of turning points as a methodological tool and the investigation of deviant fields. Finally, our defense of the interactionist perspective as suitable for career studies, since it allows the investigation of deviant elements.

  13. Increase the glyde path diameter improves the centering ability of F6 Skytaper.

    Science.gov (United States)

    Troiano, Giuseppe; Dioguardi, Mario; Cocco, Armando; Zhurakivska, Khrystyna; Ciavarella, Domenico; Muzio, Lorenzo Lo

    2018-01-01

    The aim of this study was to assess the impact of glide path preparation, performed with PathGlider 0.15 (Komet Brasseler GmbH & Co., Lemgo, Germany) and PathGlider 0.20 (Komet Brasseler GmbH & Co., Lemgo, Germany), on the centering ability of 25-size F6 Skytaper in J-shape simulated root canals, compared with no glide path executed. Sixty J-shaped ISO 15 0.02 taper endo training blocks (Dentsply Maillefer) were assigned to three groups ( n = 20 for each group). Photographic images were taken on endoblocks before and after shaping procedures. After superimposition, the software AutoCAD 2013 (Autodesk Inc., San Rafael, USA) was used for record the centering and shaping ability at 9 different levels from the apex. Shaping procedures including the using of PathGlider 0.20 resulted in a lower amount of resin removed and in a clear improvement of centering ability of the Skytaper 0.25 at almost all reference point levels. Within the limitations of this study, it could be concluded that the glide path procedure, performed with the PathGlider 0.20 before the shaping with 25-size F6 Skytaper, might determine a lower amount of resin removed and a better centering ability compared with the groups without glide path procedure and those treated with PathGlider 0.15.

  14. Promotion of Nuclear Non-proliferation in East Asia

    International Nuclear Information System (INIS)

    Hwang, Yong Soo

    2009-07-01

    KAERI has jointly worked with Sandia National Laboratories for Nuclear Energy Non-proliferation in East Asia for the last five years. This project aims at support activities in this joint project between two states. The annual meetings were held during the project period, the 4th one in 2008 and the 5th one in 2009. In addition code comparison between KAERI and SNL's codes for assessing the back-end fuel cycle options was carried out. This project strongly enhances the close tie for the non-proliferation, transparency and safeguards among Korea Japan China Taiwan the United States Russia Malaysia Singapore Indonesia Thailand Vietnam and others for the project period

  15. Proliferation resistance criteria for fissile material disposition issues

    International Nuclear Information System (INIS)

    Rutherford, D.A.; Fearey, B.L.; Markin, J.T.; Close, D.A.; Tolk, K.M.; Mangan, D.L.; Moore, L.

    1995-01-01

    The 1994 National Acdaemy of Sciences study ''Management and Disposition of Excess Weapons Plutonium'' defined options for reducing the national and international proliferation risks of materials declared excess to the nuclear weapons program. This paper proposes criteria for assessing the proliferation resistance of these options as well defining the ''Standards'' from the report. The criteria are general, encompassing all stages of the disposition process from storage through intermediate processing to final disposition including the facilities, processing technologies and materials, the level of safeguards for these materials, and the national/subnational threat to the materials

  16. Two Generations of Path Dependence in Economics?

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2010-01-01

    Even if there is no fully articulated and generally accepted theory of Path Dependence it has eagerly been taken up across a wide range of social sciences – primarily coming from economics. Path Dependence is most of all a metaphor that offers reason to believe, that some political, social...

  17. Cooperative organic mine avoidance path planning

    Science.gov (United States)

    McCubbin, Christopher B.; Piatko, Christine D.; Peterson, Adam V.; Donnald, Creighton R.; Cohen, David

    2005-06-01

    The JHU/APL Path Planning team has developed path planning techniques to look for paths that balance the utility and risk associated with different routes through a minefield. Extending on previous years' efforts, we investigated real-world Naval mine avoidance requirements and developed a tactical decision aid (TDA) that satisfies those requirements. APL has developed new mine path planning techniques using graph based and genetic algorithms which quickly produce near-minimum risk paths for complicated fitness functions incorporating risk, path length, ship kinematics, and naval doctrine. The TDA user interface, a Java Swing application that obtains data via Corba interfaces to path planning databases, allows the operator to explore a fusion of historic and in situ mine field data, control the path planner, and display the planning results. To provide a context for the minefield data, the user interface also renders data from the Digital Nautical Chart database, a database created by the National Geospatial-Intelligence Agency containing charts of the world's ports and coastal regions. This TDA has been developed in conjunction with the COMID (Cooperative Organic Mine Defense) system. This paper presents a description of the algorithms, architecture, and application produced.

  18. Evaluation of Calcine Disposition Path Forward

    International Nuclear Information System (INIS)

    Birrer, S.A.; Heiser, M.B.

    2003-01-01

    This document describes an evaluation of the baseline and two alternative disposition paths for the final disposition of the calcine wastes stored at the Idaho Nuclear Technology and Engineering Center at the Idaho National Engineering and Environmental Laboratory. The pathways are evaluated against a prescribed set of criteria and a recommendation is made for the path forward

  19. Generalized measures and the Feynman path integral

    International Nuclear Information System (INIS)

    Maslov, V.P.; Chebotarev, A.M.

    1976-01-01

    Generalizations are obtained for the earlier results by the authors concerning the inclusion of the Feynmann path integral in the momentum representation into the general integration theory. Feynmann path integrals are considered which do not represent T-products. Generalized Feynmann measure in the configuration representation is introduced

  20. Approximate Shortest Homotopic Paths in Weighted Regions

    KAUST Repository

    Cheng, Siu-Wing; Jin, Jiongxin; Vigneron, Antoine; Wang, Yajun

    2010-01-01

    Let P be a path between two points s and t in a polygonal subdivision T with obstacles and weighted regions. Given a relative error tolerance ε ∈(0,1), we present the first algorithm to compute a path between s and t that can be deformed to P

  1. Paths and cycles in colored graphs

    NARCIS (Netherlands)

    Li, Xueliang; Zhang, Shenggui; Hurink, Johann L.; Pickl, Stefan; Broersma, Haitze J.; Faigle, U.

    2001-01-01

    Let G be an (edge-)colored graph. A path (cycle) is called monochromatic if all the edges of it have the same color, and is called heterochromatic if all the edges of it have different colors. In this note, some sufficient conditions for the existence of monochromatic and heterochromatic paths and

  2. Path Minima Queries in Dynamic Weighted Trees

    DEFF Research Database (Denmark)

    Davoodi, Pooya; Brodal, Gerth Stølting; Satti, Srinivasa Rao

    2011-01-01

    In the path minima problem on a tree, each edge is assigned a weight and a query asks for the edge with minimum weight on a path between two nodes. For the dynamic version of the problem, where the edge weights can be updated, we give data structures that achieve optimal query time\\todo{what about...

  3. Approximate shortest homotopic paths in weighted regions

    KAUST Repository

    Cheng, Siuwing; Jin, Jiongxin; Vigneron, Antoine E.; Wang, Yajun

    2012-01-01

    A path P between two points s and t in a polygonal subdivision T with obstacles and weighted regions defines a class of paths that can be deformed to P without passing over any obstacle. We present the first algorithm that, given P and a relative

  4. from synchronic variation to a grammaticalization path

    African Journals Online (AJOL)

    Kate H

    Abstract. The authors argue that the synchronic variation of cognate objects of weather verbs exhibited in six African languages of South Africa (Sepedi, Sesotho, Tshivenda, isiXhosa, Xitsonga, and. isiZulu) has a diachronic explanation, and may be represented as a grammaticalization path. This path gradually leads from ...

  5. Optimization of educational paths for higher education

    Science.gov (United States)

    Tarasyev, Alexandr A.; Agarkov, Gavriil; Medvedev, Aleksandr

    2017-11-01

    In our research, we combine the theory of economic behavior and the methodology of increasing efficiency of the human capital to estimate the optimal educational paths. We provide an optimization model for higher education process to analyze possible educational paths for each rational individual. The preferences of each rational individual are compared to the best economically possible educational path. The main factor of the individual choice, which is formed by the formation of optimal educational path, deals with higher salaries level in the chosen economic sector after graduation. Another factor that influences on the economic profit is the reduction of educational costs or the possibility of the budget support for the student. The main outcome of this research consists in correction of the governmental policy of investment in human capital based on the results of educational paths optimal control.

  6. The European dimension in non-proliferation

    International Nuclear Information System (INIS)

    Krause, J.

    1996-01-01

    Europe was for decades the focal point of efforts to prevent or constrain nuclear proliferation and the first region in which non-proliferation efforts failed. Paper deals with current proliferation problems in Europe, namely, diversion of weapons, diversion from dismantling, production over-capacity, security concerns. Legal instruments against proliferation in Europe described here include development of international norms; instruments of security assurance and cooperation; disarmament assistance; fissile material management; assistance in creating export control systems; improving and harmonizing export controls for dual-purpose items. Problems in implementing non-proliferation instruments are described separately

  7. The international nuclear non-proliferation system

    International Nuclear Information System (INIS)

    Simpson, J.; McGrew, T.

    1985-01-01

    This volume focuses upon the issues raised at this Conference, and attempts to address the international diplomatic, political and trading, rather than technical, questions which surround nuclear non-proliferation policies. It does so by bringing together chapters contributed by participants in non-proliferation diplomacy, those with experience in shaping International Atomic Energy Agency and national policies and academic observers of non-proliferation activities and the international nuclear industry. An analysis is provided of past non-proliferation policies and activities and current issues, and an attempt is made to offer ideas for new initiatives which may sustain the non-proliferation system in the future

  8. Accelerating Sequential Gaussian Simulation with a constant path

    Science.gov (United States)

    Nussbaumer, Raphaël; Mariethoz, Grégoire; Gravey, Mathieu; Gloaguen, Erwan; Holliger, Klaus

    2018-03-01

    Sequential Gaussian Simulation (SGS) is a stochastic simulation technique commonly employed for generating realizations of Gaussian random fields. Arguably, the main limitation of this technique is the high computational cost associated with determining the kriging weights. This problem is compounded by the fact that often many realizations are required to allow for an adequate uncertainty assessment. A seemingly simple way to address this problem is to keep the same simulation path for all realizations. This results in identical neighbourhood configurations and hence the kriging weights only need to be determined once and can then be re-used in all subsequent realizations. This approach is generally not recommended because it is expected to result in correlation between the realizations. Here, we challenge this common preconception and make the case for the use of a constant path approach in SGS by systematically evaluating the associated benefits and limitations. We present a detailed implementation, particularly regarding parallelization and memory requirements. Extensive numerical tests demonstrate that using a constant path allows for substantial computational gains with very limited loss of simulation accuracy. This is especially the case for a constant multi-grid path. The computational savings can be used to increase the neighbourhood size, thus allowing for a better reproduction of the spatial statistics. The outcome of this study is a recommendation for an optimal implementation of SGS that maximizes accurate reproduction of the covariance structure as well as computational efficiency.

  9. Nanoparticles for cells proliferation enhancement

    International Nuclear Information System (INIS)

    Popa, V.; Braniste, F.; Tiginyanu, I.M.; Lisii, C.; Nacu, V.

    2013-01-01

    The potential of semiconductor nanoparticles as stimulator for avian mesenchyme stem cells proliferation enhancement is demonstrated. The effect is related to nanoparticles polarization due to external ultrasound field resulting in local electrical stimulation. Our preliminary results demonstrates that the number of cells have been increased by 23 % ±2%) in cell cultures under the action of external ultrasound stimulation. Morphological analysis and viability shows no differences between the control group and the group studied. These results suggest the possibility for tissue regeneration enhancement by remote stimulation of implanted semiconductor nanoparticles. (authors)

  10. Internationalization: an alternative to nuclear proliferation

    International Nuclear Information System (INIS)

    Meller, E.

    1980-01-01

    Leading personalities in the field of nuclear energy worldwide assess possible improvements to the present nonproliferation regime and explore the possibilities for the internationalization of sensitive parts of the nuclear fuel cycle. Their studies address past and current nonproliferation policies, the current controversy between the United States and its European allies on the development of fast breeder reactors and plutonium recycling, implications of the recent US Non-Proliferation Act of 1978 upon US/Euratom relations, industrial government relationships, safety concerns, and the special needs of developing countries. Their conclusions stress the recognition of complex factors such as military security, technical competition, the spread of nuclear technology, and politics that will limit any mechanism to govern nonproliferation. They urge greater effort in educating the public to the political and economic complexities of nuclear power and recommend strengthening international agreements and other arrangements, including controls and safeguards, and the general rules for the international trade of nuclear fuel. 11 figures, 7 tables

  11. Neuronal migration and proliferation disorders: Radiologic findings

    International Nuclear Information System (INIS)

    Tampieri, D.; Melanson, D.; Ethier, R.

    1987-01-01

    Loss of control of normal neuronal migration and proliferation can cause a malformation in the central nervous system (CNS). Depending on its chronologic occurrence, the authors can distinguish different types of disorders characterized by a more or less diffuse involvement of the brain. Seven patients, aged 10 months to 18 years, with uncontrolled seizures underwent a complete clinical and radiological (skull radiography, CT, MR imaging) evaluation. In five patients surgery was performed. The aim of the study was to match the radiologic and the pathologic findings in order to establish a radiologic nomenclature. Three types of disorders were found: diffuse dysplasia (two cases), unilateral dysplasis (two cases), and focal cortical dysplasia (three cases). MR imaging, because of its superb ability to display anatomy and to distinguish between gray and white matter, is superior to CT as it allows the complete assessment of these rare cerebral disorders

  12. Back-end of the fuel cycle and non-proliferation strategies

    Energy Technology Data Exchange (ETDEWEB)

    Chebeskov, A.N.; Oussanov, V.I.; Iougai, S.V.; Pshakin, G.M. [Institute of Physics and Power Engineering, State Scientific Center of Russian Federation, Obninsk (Russian Federation)

    2001-07-01

    The paper focuses on the problem of fissile materials proliferation risk estimation. Some methodological approaches to the solution of this task and results of their application for comparison of different nuclear fuel cycle strategies are discussed. The results of comparative assessment of non-proliferation aspects of plutonium utilization alternatives in Russia using system analysis approach are presented. (author)

  13. Back-end of the fuel cycle and non-proliferation strategies

    International Nuclear Information System (INIS)

    Chebeskov, A.N.; Oussanov, V.I.; Iougai, S.V.; Pshakin, G.M.

    2001-01-01

    The paper focuses on the problem of fissile materials proliferation risk estimation. Some methodological approaches to the solution of this task and results of their application for comparison of different nuclear fuel cycle strategies are discussed. The results of comparative assessment of non-proliferation aspects of plutonium utilization alternatives in Russia using system analysis approach are presented. (author)

  14. The USA and proliferation in Northeast Asia

    International Nuclear Information System (INIS)

    Weeks, S.B.

    1995-01-01

    United States policy on proliferation in Northeast Asia poses a test of balance between general US global non-proliferation goals and specific US regional security goals for Northeast Asia. US policy on proliferation in Northeast Asia further poses a test of priorities for US bilateral relations with the key Northeast Asian states, as non-proliferation and regional security goals must be weighed against other (e.g., economic, human rights) declared US policy goals. The result is a US policy equation for Northeast Asia proliferation that is considerably more complex in execution than might be expected from the simple statement of the US goal to avoid nuclear proliferation in Northeast Asia. The question of security assurances - both negative and positive - may be closely related to US policies to avoid proliferation in Northeast Asia

  15. Suggested non-proliferation criteria for commercial nuclear fuel cycles

    International Nuclear Information System (INIS)

    Laney, R.V.; Heubotter, P.R.

    1978-01-01

    Based on the Administration's policy to prevent nuclear weapons proliferation through diversion of fuel from commercial reactor fuel cycles, a ''benchmark'' set of nonproliferation criteria was prepared for the commercial nuclear fuel cycle. These criteria should eliminate incremental risks of proliferation beyond those inherent in the present generation of low-enriched-uranium-fueled reactors operating in a once-through mode, with internationally safeguarded storage of spent fuel. They focus on the balanced application of technical constraints consistent with the state of the technology, with minimal requirements for institutional constraints, to provide a basis for assessing the proliferation resistance of proposed fission power systems. The paper contains: (1) our perception of the nuclear energy policy and of the baseline proliferation risk accepted under this policy; (2) objectives for a reactor and fuel cycle strategy which address the technical, political, and institutional aspects of diversion and proliferation and, at the same time, satisfy the Nation's needs for efficient, timely, and economical utilization of nuclear fuel resources; (3) criteria which are responsive to these objectives and can therefore be used to screen proposed reactor and fuel cycle strategies; and (4) a rationale for these criteria

  16. Technical features to enhance proliferation resistance of nuclear energy systems

    International Nuclear Information System (INIS)

    2010-01-01

    It is generally accepted that proliferation resistance is an essential issue for the continued development and sustainability of nuclear energy. Several comprehensive assessment activities on the proliferation resistance of the nuclear fuel cycle have previously been completed, notably the International Nuclear Fuel Cycle Evaluation (INFCE) carried out under the auspices of the IAEA, and the Non-proliferation Alternative Systems Assessment Program (NASAP) review carried out by the USA. There have been, however, relatively few comprehensive treatments of the issue following these efforts in the 1970s. However, interest in and concern about this issue have increased recently, particularly because of greater interest in innovative nuclear fuel cycles and systems. In 2000, the IAEA initiated the International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO) and the US Department of Energy initiated the Generation IV International Forum (GIF). These projects are aimed at the selection and development of concepts of innovative nuclear energy systems and fuel cycles. Proliferation resistance is one of the fundamental considerations for both projects. In this context, the IAEA in 2001 initiated a study entitled 'Technical Aspects of Increasing Proliferation Resistance of the Nuclear Fuel Cycle'. This task is not intended as an effort to assess the merits of a particular fuel cycle system for the future, but to describe a qualitative framework for an examination of the proliferation resistance provided by the intrinsic features of an innovative nuclear energy system and fuel cycle. This task also seeks to provide a high level survey of a variety of innovative nuclear energy systems and fuel cycles with respect to that framework. The concept of proliferation resistance is considered in terms of intrinsic features and extrinsic measures. The intrinsic features, sometimes referred to as the physical/technical aspects, are those features that result from the

  17. Non-proliferation and disarmament

    International Nuclear Information System (INIS)

    Ritter von Wagner, A.

    1993-01-01

    In 1995 the Conference on the prolongation of the Non-Proliferation Treaty will take place. Will it be extended for a long term, indefinitely or only for a fixed period? The Federal Government of Germany advocates an unlimited extension of the Non-Proliferation Treaty. Others have different ideas alleging that the Treaty is imperfect and discriminating. It is a thorn in the side of many States, in particular of the Third World, which no longer want to put up with being treated as second-class states. One argument which is considered especially embarrassing by developing countries as a visible expression of such discrimination, are the nuclear tests which are still carried out by nuclear weapon states. Is the political situation still such that one needs those weapons? Strategists gradually find it difficult to argument; over and over again they claim that an abandonment of nuclear weapons would make the world unsafer. But development has gradually passed over them. Nevertheless, one finds it hard to throw overboard considerations which for years have determined one's thinking. (orig./HSCH) [de

  18. Gas Centrifuges and Nuclear Proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Albright, David

    2004-09-15

    Gas centrifuges have been an ideal enrichment method for a wide variety of countries. Many countries have built gas centrifuges to make enriched uranium for peaceful nuclear purposes. Other countries have secretly sought centrifuges to make highly enriched uranium for nuclear weapons. In more recent times, several countries have secretly sought or built gas centrifuges in regions of tension. The main countries that have been of interest in the last two decades have been Pakistan, Iraq, Iran, and North Korea. Currently, most attention is focused on Iran, Pakistan, and North Korea. These states did not have the indigenous abilities to make gas centrifuges, focusing instead on illicit and questionable foreign procurement. The presentation covered the following main sections: Spread of centrifuges through illicit procurement; Role of export controls in stopping proliferation; Increasing the transparency of gas centrifuge programs in non-nuclear weapon states; and, Verified dismantlement of gas centrifuge programs. Gas centrifuges are important providers of low enriched uranium for civil nuclear power reactors. They also pose special nuclear proliferation risks. We all have special responsibilities to prevent the spread of gas centrifuges into regions of tension and to mitigate the consequences of their spread into the Middle East, South Asia, and North Asia.

  19. Multi-AGV path planning with double-path constraints by using an improved genetic algorithm.

    Directory of Open Access Journals (Sweden)

    Zengliang Han

    Full Text Available This paper investigates an improved genetic algorithm on multiple automated guided vehicle (multi-AGV path planning. The innovations embody in two aspects. First, three-exchange crossover heuristic operators are used to produce more optimal offsprings for getting more information than with the traditional two-exchange crossover heuristic operators in the improved genetic algorithm. Second, double-path constraints of both minimizing the total path distance of all AGVs and minimizing single path distances of each AGV are exerted, gaining the optimal shortest total path distance. The simulation results show that the total path distance of all AGVs and the longest single AGV path distance are shortened by using the improved genetic algorithm.

  20. Phages of life - the path to pharma.

    Science.gov (United States)

    Forde, Amanda; Hill, Colin

    2018-02-01

    Bacteriophage (phage) therapy has encountered both enthusiasm and scepticism in the past century. New antimicrobial strategies against lethal pathogens are now a top priority for the World Health Organization, and although compassionate use of phages recently met with significant success, regulated clinical interventions seem unlikely in the near future. The hundredth anniversary of their discovery seems an appropriate time for a revival of phage therapy, particularly as the dilemma of antibiotic resistance grows. Phages are ubiquitous in the environment, on our food and in and on our bodies. Their influence on human health is currently being evaluated, and in this mini-review, we examine data from recent metagenomic studies that propose a role for phages in the structure of the microbiome and in health and disease. We assess evidence for phages as vehicles for gene transfer in the context of antibiotic resistance and discuss challenges and opportunities along the critical path from phage discovery to a patient-focused pharmaceutical intervention. © 2017 The British Pharmacological Society.

  1. Ambivalent journey: Teacher career paths in Oman

    Science.gov (United States)

    Chapman, David W.; Al-Barwani, Thuwayba; Mawali, Fathiya Al; Green, Elizabeth

    2012-06-01

    This study investigated the career paths of 625 university graduates who prepared to be secondary school teachers in Oman, their assessment of their current work situation, and the extent to which their initial commitment to teaching was related to their subsequent career satisfaction and intention to remain in teaching. While nearly all graduates entered teaching, their decision was marked by ambivalence. Nearly half of the graduates reported being only somewhat or not at all committed to teaching as a career when they graduated. It also appears that initial commitment to teaching operates as an important lens through which teachers view their subsequent careers. Those initially more committed to teaching were more likely to be satisfied with the progress they made in their career, more likely to think that their current teaching position offered them opportunities for advancement, and more likely to want to remain in teaching than were graduates who had a lower initial commitment to teaching. The authors discuss both the theoretical and practical implications of these findings.

  2. Eyes On the Ground: Path Forward Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Brost, Randolph; Little, Charles Q.; peter-stein, natacha; Wade, James Rokwel

    2018-03-01

    A previous report assesses our progress to date on the Eyes On the Ground project, and reviews lessons learned [1]. In this report, we address the implications of those lessons in defining the most productive path forward for the remainder of the project. We propose two main concepts: Interactive Diagnosis and Model-Driven Assistance. Among these, the Model-Driven Assistance concept appears the most promising. The Model-Driven Assistance concept is based on an approximate but useful model of a facility, which provides a unified representation for storing, viewing, and analyzing data that is known about the facility. This representation provides value to both inspectors and IAEA headquarters, and facilitates communication between the two. The concept further includes a lightweight, portable field tool to aid the inspector in executing a variety of inspection tasks, including capture of images and 3-d scan data. We develop a detailed description of this concept, including its system components, functionality, and example use cases. The envisioned tool would provide value by reducing inspector cognitive load, streamlining inspection tasks, and facilitating communication between the inspector and teams at IAEA headquarters. We conclude by enumerating the top implementation priorities to pursue in the remaining limited time of the project. Approved for public release; further dissemination unlimited.

  3. Integrated path towards geological storage

    International Nuclear Information System (INIS)

    Bouchard, R.; Delaytermoz, A.

    2004-01-01

    Among solutions to contribute to CO 2 emissions mitigation, sequestration is a promising path that presents the main advantage of being able to cope with the large volume at stake when considering the growing energy demand. Of particular importance, geological storage has widely been seen as an effective solution for large CO 2 sources like power plants or refineries. Many R and D projects have been initiated, whereby research institutes, government agencies and end-users achieve an effective collaboration. So far, progress has been made towards reinjection of CO 2 , in understanding and then predicting the phenomenon and fluid dynamics inside the geological target, while monitoring the expansion of the CO 2 bubble in the case of demonstration projects. A question arises however when talking about sequestration, namely the time scale to be taken into account. Time is indeed of the essence, and points out the need to understand leakage as well as trapping mechanisms. It is therefore of prime importance to be able to predict the fate of the injected fluids, in an accurate manner and over a relevant period of time. On the grounds of geology, four items are involved in geological storage reliability: the matrix itself, which is the recipient of the injected fluids; the seal, that is the mechanistic trap preventing the injected fluids to flow upward and escape; the lower part of the concerned structure, usually an aquifer, that can be a migration way for dissolved fluids; and the man- made injecting hole, the well, whose characteristics should be as good as the geological formation itself. These issues call for specific competencies such as reservoir engineering, geology and hydrodynamics, mineral chemistry, geomechanics, and well engineering. These competencies, even if put to use to a large extent in the oil industry, have never been connected with the reliability of geological storage as ultimate goal. This paper aims at providing an introduction to these

  4. Steam Turbine Flow Path Seals (a Review)

    Science.gov (United States)

    Neuimin, V. M.

    2018-03-01

    Various types of shroud, diaphragm, and end seals preventing idle leak of working steam are installed in the flow paths of steam turbine cylinders for improving their efficiency. Widely known labyrinth seals are most extensively used in the Russian turbine construction industry. The category of labyrinth seals also includes seals with honeycomb inserts. The developers of seals with honeycomb inserts state that the use of such seals makes it possible to achieve certain gain due to smaller leaks of working fluid and more reliable operation of the system under the conditions in which the rotor rotating parts may rub against the stator elements. However, a positive effect can only be achieved if the optimal design parameters of the honeycomb structure are fulfilled with due regard to the specific features of its manufacturing technology and provided that this structure is applied in a goal-seeking manner in the seals of steam and gas turbines and compressors without degrading their vibration stability. Calculated and preliminary assessments made by experts testify that the replacement of conventional labyrinth seals by seals with honeycomb inserts alone, due to which the radial gaps in the shroud seal can be decreased from 1.5 to 0.5 mm, allows the turbine cylinder efficiency to be increased at the initial stage by approximately 1% with the corresponding gain in the turbine set power output. The use of rectangular-cellular seals may result, according to estimates made by their developers, in a further improvement of turbine efficiency by 0.5-1.0%. The labor input required to fabricate such seals is six to eight times smaller than that to fabricate labyrinth seals with honeycomb inserts. Recent years have seen the turbine construction companies of the United States and Germany advertising the use of abradable (sealing) coatings (borrowed from the gas turbine construction technology) in the turbine designs instead of labyrinth seals. The most efficient performance of

  5. Detection of cervical precancerous lesions with Aptima HPV assays using SurePath preservative fluid specimens

    Directory of Open Access Journals (Sweden)

    Max Chernesky

    2017-06-01

    Full Text Available SurePath specimens from women referred to colposcopy were treated with Aptima Transfer Solution (ATS before testing in Aptima HPV (AHPV and Aptima HPV 16, 18/45 (AHPV-GT assays. Untreated SurePath specimens were tested with the cobas HPV test. PreservCyt specimens were assessed for cytology and tested with AHPV. High-grade cervical intraepithelial neoplasia lesions served as the reference standard. Excellent agreement (95.5%; k=0.91 was observed for ATS-treated SurePath specimens between Tigris and Panther systems and between the PreservCyt and ATS-treated SurePath specimens (91.1%, k=0.81 with the AHPV assay on Tigris. Agreement between the AHPV and cobas assays with SurePath specimens was substantial (89.9%, k=0.80. AHPV sensitivity for CIN2+(n=147 was 91.2% for SurePath and PreservCyt. Cobas HPV sensitivity was 93.9% for SurePath specimens. AHPV testing of SurePath specimens was more specific (59.4% than cobas (54.7% (p<0.001. Detection and genotyping showed similar absolute and relative risks. ATS-treated SurePath specimens tested with AHPV and AHPV-GT assays showed similar performance with greater specificity than cobas HPV on SurePath specimens. Similar overall results were seen using a CIN3 disease endpoint. Keywords: Human papillomavirus, SurePath, PreservCyt, Cervical intraepithelial neoplasia, CIN2+, Aptima transfer solution (ATS

  6. Integrated robust controller for vehicle path following

    Energy Technology Data Exchange (ETDEWEB)

    Mashadi, Behrooz; Ahmadizadeh, Pouyan, E-mail: p-ahmadizadeh@iust.ac.ir; Majidi, Majid, E-mail: m-majidi@iust.ac.ir [Iran University of Science and Technology, School of Automotive Engineering (Iran, Islamic Republic of); Mahmoodi-Kaleybar, Mehdi, E-mail: m-mahmoodi-k@iust.ac.ir [Iran University of Science and Technology, School of Mechanical Engineering (Iran, Islamic Republic of)

    2015-02-15

    The design of an integrated 4WS+DYC control system to guide a vehicle on a desired path is presented. The lateral dynamics of the path follower vehicle is formulated by considering important parameters. To reduce the effect of uncertainties in vehicle parameters, a robust controller is designed based on a μ-synthesis approach. Numerical simulations are performed using a nonlinear vehicle model in MATLAB environment in order to investigate the effectiveness of the designed controller. Results of simulations show that the controller has a profound ability to making the vehicle track the desired path in the presence of uncertainties.

  7. Path integral for relativistic particle theory

    International Nuclear Information System (INIS)

    Fradkin, E.S.; Gitman, D.M.; Shvartsman, Sh.M.

    1990-06-01

    An action for a relativistic spinning particle interacting with external electromagnetic field is considered in reparametrization and local supergauge invariant form. It is shown that various path integral representations derived for the causal Green function correspond to the different forms of the relativistic particle action. The analogy of the path integral derived with the Lagrangian path integral of the field theory is discussed. It is shown that to obtain the causal propagator, the integration over the null mode of the Lagrangian multiplier corresponding to the reparametrization invariance, has to be performed in the (0,+infinity) limits. (author). 23 refs

  8. Integrated robust controller for vehicle path following

    International Nuclear Information System (INIS)

    Mashadi, Behrooz; Ahmadizadeh, Pouyan; Majidi, Majid; Mahmoodi-Kaleybar, Mehdi

    2015-01-01

    The design of an integrated 4WS+DYC control system to guide a vehicle on a desired path is presented. The lateral dynamics of the path follower vehicle is formulated by considering important parameters. To reduce the effect of uncertainties in vehicle parameters, a robust controller is designed based on a μ-synthesis approach. Numerical simulations are performed using a nonlinear vehicle model in MATLAB environment in order to investigate the effectiveness of the designed controller. Results of simulations show that the controller has a profound ability to making the vehicle track the desired path in the presence of uncertainties

  9. Path-Goal Theory of Leadership

    Science.gov (United States)

    1975-04-01

    Leadership and Turnover Among Managers ," Organization Behavior and Human Performance, 10(1973), pp. 184-200; R. J. House, "A Path-Goal Theory of...of Leadership ." 6R. J. House and G. Dessler, "Path-Goal Theory of Leadership " R. M. Stqg- dill. Managers , Employees, Organization (Ohio State...of Control." 23 R. J. House, "Notes on the Path-Goal Theory of Leadership " (University of Toronto, Faculty of Management Studies, May 1974). 24 R

  10. Path integral representations on the complex sphere

    Energy Technology Data Exchange (ETDEWEB)

    Grosche, C. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2007-08-15

    In this paper we discuss the path integral representations for the coordinate systems on the complex sphere S{sub 3C}. The Schroedinger equation, respectively the path integral, separates in exactly 21 orthogonal coordinate systems. We enumerate these coordinate systems and we are able to present the path integral representations explicitly in the majority of the cases. In each solution the expansion into the wave-functions is stated. Also, the kernel and the corresponding Green function can be stated in closed form in terms of the invariant distance on the sphere, respectively on the hyperboloid. (orig.)

  11. Path probabilities of continuous time random walks

    International Nuclear Information System (INIS)

    Eule, Stephan; Friedrich, Rudolf

    2014-01-01

    Employing the path integral formulation of a broad class of anomalous diffusion processes, we derive the exact relations for the path probability densities of these processes. In particular, we obtain a closed analytical solution for the path probability distribution of a Continuous Time Random Walk (CTRW) process. This solution is given in terms of its waiting time distribution and short time propagator of the corresponding random walk as a solution of a Dyson equation. Applying our analytical solution we derive generalized Feynman–Kac formulae. (paper)

  12. Path integral representations on the complex sphere

    International Nuclear Information System (INIS)

    Grosche, C.

    2007-08-01

    In this paper we discuss the path integral representations for the coordinate systems on the complex sphere S 3C . The Schroedinger equation, respectively the path integral, separates in exactly 21 orthogonal coordinate systems. We enumerate these coordinate systems and we are able to present the path integral representations explicitly in the majority of the cases. In each solution the expansion into the wave-functions is stated. Also, the kernel and the corresponding Green function can be stated in closed form in terms of the invariant distance on the sphere, respectively on the hyperboloid. (orig.)

  13. Positroids Induced by Rational Dyck Paths

    OpenAIRE

    Gotti, Felix

    2017-01-01

    A rational Dyck path of type $(m,d)$ is an increasing unit-step lattice path from $(0,0)$ to $(m,d) \\in \\mathbb{Z}^2$ that never goes above the diagonal line $y = (d/m)x$. On the other hand, a positroid of rank $d$ on the ground set $[d+m]$ is a special type of matroid coming from the totally nonnegative Grassmannian. In this paper we describe how to naturally assign a rank $d$ positroid on the ground set $[d+m]$, which we name rational Dyck positroid, to each rational Dyck path of type $(m,d...

  14. Unusual bond paths in organolithium compounds

    International Nuclear Information System (INIS)

    Bachrach, S.M.; Ritchie, J.P.

    1986-01-01

    We have applied the topological method to a number of organolithium compounds. The wavefunctions were determined with GAUSSIAN-82 using 3-21G basis set and fully optimized geometries. Gradient paths were obtained using the RHODER package and critical points were located using EXTREME. These results indicate the unusual nature of organolithium compounds. The strange bond paths arise mainly from the ionic nature of the C-Li interaction. We suggest that the term ''bond path'' may best be suited for covalent bonds. 4 figs., 1 tab

  15. New framework for the Feynman path integral

    International Nuclear Information System (INIS)

    Shaharir, M.Z.

    1986-01-01

    The well-known Fourier integral solution of the free diffusion equation in an arbitrary Euclidean space is reduced to Feynmannian integrals using the method partly contained in the formulation of the Fresnelian integral. By replacing the standard Hilbert space underlying the present mathematical formulation of the Feynman path integral by a new Hilbert space, the space of classical paths on the tangent bundle to the Euclidean space (and more general to an arbitrary Riemannian manifold) equipped with a natural inner product, we show that our Feynmannian integral is in better agreement with the qualitative features of the original Feynman path integral than the previous formulations of the integral

  16. Realizing spaces as path-component spaces

    OpenAIRE

    Banakh, Taras; Brazas, Jeremy

    2018-01-01

    The path component space of a topological space $X$ is the quotient space $\\pi_0(X)$ whose points are the path components of $X$. We show that every Tychonoff space $X$ is the path-component space of a Tychonoff space $Y$ of weight $w(Y)=w(X)$ such that the natural quotient map $Y\\to \\pi_0(Y)=X$ is a perfect map. Hence, many topological properties of $X$ transfer to $Y$. We apply this result to construct a compact space $X\\subset \\mathbb{R}^3$ for which the fundamental group $\\pi_1(X,x_0)$ is...

  17. Proliferation resistance fuel cycle technology

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. S.; Ko, W. I

    1999-02-01

    The issues of dual use in nuclear technology are analysed for nuclear fuel cycle with special focus on uranium enrichment and spent fuel reprocessing which are considered as the most sensitive components in terms of vulnerability to diversion. Technical alternatives to mitigrate the vulnerability, as has been analysed in depth during the NASAP and INFCE era in the late seventies, are reviewed to characterize the DUPIC fuel cycle alternative. On the other hand, the new realities in nuclear energy including the disposition of weapon materials as a legacy of cold war are recast in an angle of nuclear proliferation resistance and safeguards with a discussion on the concept of spent fuel standard concept and its compliance with the DUPIC fuel cycle technology. (author)

  18. Missile proliferation and missile defense

    International Nuclear Information System (INIS)

    Zarif, M. Javad

    2002-01-01

    The global security environment is becoming increasingly volatile and dangerous. A new arms race is looming in the horizon ... [Missiles have] become the strong weapon of the poor and the discriminated against who find themselves vulnerable to outside threat. They believe missiles may prove instrumental in deterring the enemy from beginning a full scale war ... the engagement of all states at the United Nations in the issue of missiles, through the panel of governmental experts, and the new idea of exploring the subject in the Conference on Disarmament do provide a dim light at the end of the tunnel. ... Efforts at non-proliferation of missiles are more likely to succeed when viewed as an integral part of a global and comprehensive negotiation and progress in other areas of disarmament. (author)

  19. Euclidean shortest paths exact or approximate algorithms

    CERN Document Server

    Li, Fajie

    2014-01-01

    This book reviews algorithms for the exact or approximate solution of shortest-path problems, with a specific focus on a class of algorithms called rubberband algorithms. The coverage includes mathematical proofs for many of the given statements.

  20. Northern Pintail - Flight Path Telemetry [ds117

    Data.gov (United States)

    California Natural Resource Agency — North-south flight paths of radio-tagged female northern pintails were monitored in a section of Highway 152 near Los Banos, California during 4 and 11 November and...

  1. AEDT sensor path methods using BADA4

    Science.gov (United States)

    2017-06-01

    This report documents the development and use of sensor path data processing in the Federal Aviation Administration's (FAAs) Aviation Environmental Design Tool (AEDT). The methods are primarily intended to assist analysts with using AEDT to determ...

  2. Modeling and Solving the Train Pathing Problem

    Directory of Open Access Journals (Sweden)

    Chuen-Yih Chen

    2009-04-01

    Full Text Available In a railroad system, train pathing is concerned with the assignment of trains to links and tracks, and train timetabling allocates time slots to trains. In this paper, we present an optimization heuristic to solve the train pathing and timetabling problem. This heuristic allows the dwell time of trains in a station or link to be dependent on the assigned tracks. It also allows the minimum clearance time between the trains to depend on their relative status. The heuristic generates a number of alternative paths for each train service in the initialization phase. Then it uses a neighborhood search approach to find good feasible combinations of these paths. A linear program is developed to evaluate the quality of each combination that is encountered. Numerical examples are provided.

  3. Search Path Evaluation Incorporating Object Placement Structure

    National Research Council Canada - National Science Library

    Baylog, John G; Wettergren, Thomas A

    2007-01-01

    This report describes a computationally robust approach to search path performance evaluation where the objects of search interest exhibit structure in the way in which they occur within the search space...

  4. Romania non-proliferation policy

    International Nuclear Information System (INIS)

    Biro, Lucian; Grama, Viviana

    2001-01-01

    Full text: Non-proliferation concept in Romania is based on the Treaty on the Non-proliferation of Nuclear Weapons, which was ratified in 1970. According to the Article III of the Treaty, Romania ratified in 1972, the Agreement between Romania and IAEA for the application of Safeguards in connection with the Treaty on the Non-proliferation of Nuclear Weapons. In 2000 Romania ratified the Additional Protocol to contribute through increased transparency, to confidence that no undeclared nuclear activities are concealed within the declared programme or make use of elements of that programme. Under the Additional Protocol Romania understands to increase the transparency of its nuclear activities lengthways fuel cycle. Romania has a strong legal framework to control nuclear material and nuclear activities. The Law 111/1996, republished is the Law on the safe deployment of nuclear activities. CNCAN issued National Regulations for Safeguards and Physical Protection. Prospecting for uranium in Romania was initiated in 1950. Between 1962 and 1978 all the uranium ore production was stockpiled at the mine sites. In 1978 the Feldioara Powder Plant was commissioned, since then both ore stockpiles and ore exploited have been processed to uranium chemical concentrates. The Powder Plant Feldioara was conceived and built following the necessity of milling and processing the uranium ore to UO 2 , in concordance with the national nuclear programme in order to produce electric energy from nuclear fuel. The Nuclear Fuel Plant has capability to manufacture CANDU-6 nuclear fuel. Nuclear Fuel Plant consists of two Production areas, the Quality Assurance and Engineering Departments. There are two Production Departments: Pelleting area including granulation, pressing, sintering, pellet grinding, uranium recycling and Assembling area including components fabrication, beryllium coating, brazing, graphite coating, fuel element and bundle assembly welding. Romania's Strategy for Energy Sector

  5. Multiagent path-finding in strategic games

    OpenAIRE

    Mihevc, Simon

    2014-01-01

    In this thesis I worked on creating, comparing and improving algorithms for multi-agent path planning on a domain typical for real-time strategy games. I implemented and compared Multiagent pathfinding using clearance and Multiagent pathfinding using independence detection and operator decomposition. I discovered that they had problems maintaining group compactness and took too long to calculate the path. I considerably improved the efficiency of both algorithms.

  6. Diversion Path Analysis Handbook. Volume 1. Methodology

    International Nuclear Information System (INIS)

    Goodwin, K.E.; Schleter, J.C.; Maltese, M.D.K.

    1978-11-01

    Diversion Path Analysis (DPA) is a safeguards evaluation tool which is used to determine the vulnerability of the Material Control and Material Accounting (MC and MA) Subsystems to the threat of theft of Special Nuclear Material (SNM) by a knowledgeable Insider. The DPA team should consist of two individuals who have technical backgrounds. The implementation of DPA is divided into five basic steps: Information and Data Gathering, Process Characterization, Analysis of Diversion Paths, Results and Findings, and Documentation

  7. Feasible Path Planning for Autonomous Vehicles

    Directory of Open Access Journals (Sweden)

    Vu Trieu Minh

    2014-01-01

    Full Text Available The objective of this paper is to find feasible path planning algorithms for nonholonomic vehicles including flatness, polynomial, and symmetric polynomial trajectories subject to the real vehicle dynamical constraints. Performances of these path planning methods are simulated and compared to evaluate the more realistic and smoother generated trajectories. Results show that the symmetric polynomial algorithm provides the smoothest trajectory. Therefore, this algorithm is recommended for the development of an automatic control for autonomous vehicles.

  8. A career path in clinical pathways.

    Science.gov (United States)

    Bower, K A

    1998-03-01

    Much like the development of a clinical path, the creation of a career path requires knowledge of patterns of behavior, needs for standardized education and skill development, along with variance analysis and individualized care. This nationally known nursing entrepreneur tells the story of her involvement in the development of case management and clinical pathways and how she turned that into a successful business that has changed how patient care is managed nationally and internationally.

  9. Lattice Paths and the Constant Term

    International Nuclear Information System (INIS)

    Brak, R; Essam, J; Osborn, J; Owczarek, A L; Rechnitzer, A

    2006-01-01

    We firstly review the constant term method (CTM), illustrating its combinatorial connections and show how it can be used to solve a certain class of lattice path problems. We show the connection between the CTM, the transfer matrix method (eigenvectors and eigenvalues), partial difference equations, the Bethe Ansatz and orthogonal polynomials. Secondly, we solve a lattice path problem first posed in 1971. The model stated in 1971 was only solved for a special case - we solve the full model

  10. China's position on nuclear non-proliferation

    International Nuclear Information System (INIS)

    Qian Jiadong.

    1986-01-01

    The paper discusses China's position on nuclear non-proliferation, in view of the fact that China does not subscribe to the Non-Proliferation Treaty (NPT). China refuses to accede to the NPT because it considers the treaty to be discriminatory, and reasons are given for this point of view. However its stand for nuclear disarmament and disapproval of nuclear proliferation are declared. Nuclear arms race, prevention of nuclear war, and nuclear disarmament are also considered. (UK)

  11. Nuclear power and nuclear-weapons proliferation

    International Nuclear Information System (INIS)

    Moniz, E.J.; Neff, T.L.

    1978-01-01

    Concern over the risk of nuclear proliferation has led to extensive reexamination of the technical, economic, and political assumptions underlying both national and international nuclear policies. An attempt is made in the present article to clarify the basic technical and political issues. The connections between various fuel cycles and their possible proliferation risks are discussed. As the resolution of the existing differing views on proliferation risks will be largely a political process, solutions to the problem are not proposed

  12. Nuclear energy and nuclear weapons proliferation

    International Nuclear Information System (INIS)

    1989-01-01

    A summary of the report dispatched in the middle of 1978 by the Atlantic Council of United States, organized by North American citizens, is presented. The report considers the relation between the production of nucleoelectric energy and the capacity of proliferation of nuclear weapons. The factors which affect the grade of proliferation risk represented by the use of nuclear energy in the world comparing this risk with the proliferation risks independently of nuclear energy, are examined. (M.C.K.) [pt

  13. Aircraft Engine Gas Path Diagnostic Methods: Public Benchmarking Results

    Science.gov (United States)

    Simon, Donald L.; Borguet, Sebastien; Leonard, Olivier; Zhang, Xiaodong (Frank)

    2013-01-01

    Recent technology reviews have identified the need for objective assessments of aircraft engine health management (EHM) technologies. To help address this issue, a gas path diagnostic benchmark problem has been created and made publicly available. This software tool, referred to as the Propulsion Diagnostic Method Evaluation Strategy (ProDiMES), has been constructed based on feedback provided by the aircraft EHM community. It provides a standard benchmark problem enabling users to develop, evaluate and compare diagnostic methods. This paper will present an overview of ProDiMES along with a description of four gas path diagnostic methods developed and applied to the problem. These methods, which include analytical and empirical diagnostic techniques, will be described and associated blind-test-case metric results will be presented and compared. Lessons learned along with recommendations for improving the public benchmarking processes will also be presented and discussed.

  14. Computing Diffeomorphic Paths for Large Motion Interpolation.

    Science.gov (United States)

    Seo, Dohyung; Jeffrey, Ho; Vemuri, Baba C

    2013-06-01

    In this paper, we introduce a novel framework for computing a path of diffeomorphisms between a pair of input diffeomorphisms. Direct computation of a geodesic path on the space of diffeomorphisms Diff (Ω) is difficult, and it can be attributed mainly to the infinite dimensionality of Diff (Ω). Our proposed framework, to some degree, bypasses this difficulty using the quotient map of Diff (Ω) to the quotient space Diff ( M )/ Diff ( M ) μ obtained by quotienting out the subgroup of volume-preserving diffeomorphisms Diff ( M ) μ . This quotient space was recently identified as the unit sphere in a Hilbert space in mathematics literature, a space with well-known geometric properties. Our framework leverages this recent result by computing the diffeomorphic path in two stages. First, we project the given diffeomorphism pair onto this sphere and then compute the geodesic path between these projected points. Second, we lift the geodesic on the sphere back to the space of diffeomerphisms, by solving a quadratic programming problem with bilinear constraints using the augmented Lagrangian technique with penalty terms. In this way, we can estimate the path of diffeomorphisms, first, staying in the space of diffeomorphisms, and second, preserving shapes/volumes in the deformed images along the path as much as possible. We have applied our framework to interpolate intermediate frames of frame-sub-sampled video sequences. In the reported experiments, our approach compares favorably with the popular Large Deformation Diffeomorphic Metric Mapping framework (LDDMM).

  15. Quantum cosmology based on discrete Feynman paths

    International Nuclear Information System (INIS)

    Chew, Geoffrey F.

    2002-01-01

    Although the rules for interpreting local quantum theory imply discretization of process, Lorentz covariance is usually regarded as precluding time quantization. Nevertheless a time-discretized quantum representation of redshifting spatially-homogeneous universe may be based on discrete-step Feynman paths carrying causal Lorentz-invariant action--paths that not only propagate the wave function but provide a phenomenologically-promising elementary-particle Hilbert-space basis. In a model under development, local path steps are at Planck scale while, at a much larger ''wave-function scale'', global steps separate successive wave-functions. Wave-function spacetime is but a tiny fraction of path spacetime. Electromagnetic and gravitational actions are ''at a distance'' in Wheeler-Feynman sense while strong (color) and weak (isospin) actions, as well as action of particle motion, are ''local'' in a sense paralleling the action of local field theory. ''Nonmaterial'' path segments and ''trivial events'' collaborate to define energy and gravity. Photons coupled to conserved electric charge enjoy privileged model status among elementary fermions and vector bosons. Although real path parameters provide no immediate meaning for ''measurement'', the phase of the complex wave function allows significance for ''information'' accumulated through ''gentle'' electromagnetic events involving charged matter and ''soft'' photons. Through its soft-photon content the wave function is an ''information reservoir''

  16. The handbook of nuclear non-proliferation

    International Nuclear Information System (INIS)

    Yang, M. H.; Lee, B. W.; Oh, K. B.; Lee, H. M.; Ko, H. S.; Ryu, J. S.; Lee, K. S.

    2003-07-01

    This report analyzed international non-proliferation regime preventing from spread of nuclear weapon. This report took review from the historical background of non-proliferation regime to the recent changes and current status. It is here divided into multilateral and bilateral regime. First of all, this report dealt four multilateral treaties concluded for international non-proliferation such as NPT, NWFZ, CTBT and others. And international organization and regimes concerned with non-proliferation are also analyzed focused on UN, IAEA, ZC and NSG, regional safeguards system and international conferences. In addition, this report reviewed the nuclear cooperation agreement related with Korea which is a important tool for bilateral regime

  17. Strengthening the non proliferation regime: French views

    International Nuclear Information System (INIS)

    Delaune, P.

    2013-01-01

    3 main issues can be identified in the French policy concerning the backing of non proliferation: 1) responding resolutely to proliferation crises, 2) reinforcing substantive efforts to prevent and impede proliferation, and 3) strengthening the non-proliferation regime. The first issue is very important because combating proliferation is vital to the security of all. Concerning the second issue, France attaches particular importance to strengthening specific measures to prevent and check proliferation. Let me mention a few proposals that we put forward: exports need to be controlled more effectively, proliferation activities have to be criminalized, or the development of proliferation-resistant technologies should be supported. Concerning the third issue it means the strengthening of the non-proliferation regime, France proposes several means: -) aiming at the universalization of the additional protocol; -) ensuring that the Agency continues to have sufficient human, financial and technical resources to fulfill its verification mission effectively; -) encouraging the IAEA to make full use of the authority available to it; -) enhancing the use of information relevant to the delivery of the IAEA mandate; and -) sharing more accurate information concerning the breaches of commitments that happen. The paper is followed by the slides of the presentation. (A.C.)

  18. A general native-state method for determination of proliferation capacity of human normal and tumor tissues in vitro

    International Nuclear Information System (INIS)

    Hoffman, R.M.; Connors, K.M.; Meerson-Monosov, A.Z.; Herrera, H.; Price, J.H.

    1989-01-01

    An important need in cancer research and treatment is a physiological means in vitro by which to assess the proliferation capacity of human tumors and corresponding normal tissue for comparison. The authors have recently developed a native-state, three-dimensional, gel-supported primary culture system that allows every type of human cancer to grow in vitro at more than 90% frequency, with maintenance of tissue architecture, tumor-stromal interaction, and differentiated functions. Here they demonstrate that the native-state culture system allows proliferation indices to be determined for all solid cancer types explanted directly from surgery into long-term culture. Normal tissues also proliferate readily in this system. The degree of resolution of measurement of cell proliferation by histological autoradiography within the cultured tissues is greatly enhanced with the use of epi-illumination polarization microscopy. The histological status of the cultured tissues can be assessed simultaneously with the proliferation status. Carcinomas generally have areas of high epithelial proliferation with quiescent stromal cells. Sarcomas have high proliferation of cells of mesenchymal organ. Normal tissues can also proliferate at high rates. An image analysis system has been developed to automate proliferation determination. The high-resolution physiological means described here to measure the proliferation capacity of tissues will be important in further understanding of the deregulation of cell proliferation in cancer as well as in cancer prognosis and treatment

  19. U.S. - India nuclear cooperation and non-proliferation

    International Nuclear Information System (INIS)

    Yash Thomas, Mannully

    2008-01-01

    The agreement for cooperation between the Government of the United States of America and the government of India concerning peaceful uses of nuclear energy (referred as 123 agreement) acknowledges a shift in international strategies and relations in both countries. As to India, it marks the end of nuclear isolation resulting from constraint, embargoes and controls and instead opens the path for nuclear commerce. With respect to the United States it entails a major geo strategic ally in the evolving South Asia region and promises large commercial benefits to the US nuclear sector. This is called 'nuclear deal' and constitutes one of the major political, economic and strategic relationship developing between the two countries since 2001. It will lead to the separation of military and civilian nuclear installations in India, the latter to be placed under the safeguards system of the International Atomic Energy Agency (IAEA). It thus, de facto accepts India in the club of nuclear weapon states within the meaning of the Treaty on the non-proliferation of nuclear weapons (NPT) although it is not party to this treaty, refuses adhering to it, officially possesses nuclear weapons and is not subject to a comprehensive system of safeguards. This article will examine the developments which led to the 123 agreement and its subsequent implementation in a wider context of international relations and non proliferation. First, the articles gives a brief introduction into the Indian nuclear programme, the legislative framework and the factors which necessitated nuclear cooperation between India and the United States. Secondly, it will address the implementation of the nuclear deal and subsequent developments. Finally, it will analyse the non proliferation issues related to the implementation of the agreement. (N.C.)

  20. Using a reflection model for modeling the dynamic feedback path of digital hearing aids

    DEFF Research Database (Denmark)

    Ma, Guilin; Gran, Fredrik; Jacobsen, Finn

    2010-01-01

    Feedback whistling is one of the severe problems with hearing aids, especially in dynamic situations when the users hug, pick up a telephone, etc. This paper investigates the properties of the dynamic feedback paths of digital hearing aids and proposes a model based on a reflection assumption...... gain. The method is also extended to dual-microphone hearing aids to assess the possibility of relating the two dynamic feedback paths through the reflection model. However, it is found that in a complicated acoustic environment, the relation between the two feedback paths can be very intricate...

  1. Survival paths through the forest

    DEFF Research Database (Denmark)

    Mogensen, Ulla Brasch

    in appropriate prevention programs it is important to assess the individual risk with high accuracy. Generally, genetic information plays an important role for many diseases and will help to improve the accuracy of existing risk prediction models. However, conventional regression models have several limitations...... when the information is high-dimensional e.g. when there are many thousands of genes or markers. In these situations machine learning methods such as the random forest can still be applied and provide reasonable prediction accuracy. The main focus in this talk is the performance of random forest...

  2. Brexit, Euratom and nuclear proliferation

    International Nuclear Information System (INIS)

    Soedersten, Anna

    2016-01-01

    One of the issues absent from the academic (and public) debate on the United Kingdom's (UK) referendum vote to withdraw from the European Union (EU) (commonly referred to as 'Brexit') is what will happen to the UK's membership in the European Atomic Energy Community (Euratom). The Euratom Treaty was signed in Rome in 1957, together with the European Economic Community (EEC) Treaty. It was concluded for an unlimited period and it establishes a Community that has a separate legal personality from the EU. Thus, the EU and Euratom form two separate, although closely linked entities. Euratom's principal mission is related to the economy, tasked with 'creating the conditions necessary for the speedy establishment and growth of nuclear industries'; in other words, to promote the nuclear industry. This reflects the high expectations for nuclear energy in the 1950's. Some even believed that the development of nuclear energy would trigger an industrial revolution; however, Euratom only came to play a minor role in the European integration process. Despite this, the Euratom Treaty has remained, almost unchanged, since its adoption and is still frequently applied, although it is unclear to what extent it has boosted the nuclear industry. This article has a two-fold purpose. The first purpose is to address the constitutional issue of 'partial membership'. All EU member states are also members of Euratom. It has always been assumed that with membership in the EU also comes a membership in Euratom. But, what about withdrawal? What are the arguments for 'partial membership'? The second purpose of this article is to shed light on some implications of Brexit as it relates to Euratom. The most serious consequences are perhaps found in the area of nuclear non-proliferation. The United Kingdom is one of two nuclear weapon states in the EU (France being the other one). Withdrawal from Euratom means withdrawal from its control system, the system of so-called nuclear safeguards. Under

  3. Mathematical optimization for planning and design of cycle paths

    Energy Technology Data Exchange (ETDEWEB)

    LiÑan Ruiz, R.J.; Perez Aracil, J.; Cabrera Cañizares, V.

    2016-07-01

    The daily need for citizens to move for different activities, whatever its nature, has been greatly affected by the changes. The advantages resulting from the inclusion of the bicycle as a mode of transport and the proliferation of its use among citizens are numerous and extend both in the field of urban mobility and sustainable development.Currently, there are a number of programs for the implementation, promotion or increased public participation related to cycling in cities. But ultimately, each and every one of these initiatives have the same goal, to create a mesh of effective, useful and cycling trails that allow the use of bicycles in preferred routes with high guarantees of security, incorporating bicycle model intermodal urban transport.With the gradual implementation of bike lanes, many people have begun to use them to get around the city. But everything again needs a period of adaptation, and the reality is that the road network for these vehicles is full of obstacles to the rider. The current situation has led to the proposal that many kilometers of cycle paths needed to supply the demand of this mode of transport and, if implemented and planned are correct and sufficient.This paper presents a mathematical programming model for optimal design of a network for cyclists is presented. Specifically, the model determines a network of bicycle infrastructure, appropriate to the characteristics of a network of existing roads.As an application of the proposed model, the result of these experiments give a number of useful conclusions for planning and designing networks of cycle paths from a social perspective, applied to the case in the city of Malaga. (Author)

  4. Proliferation after the Iraq war; La proliferation apres la guerre d'Irak

    Energy Technology Data Exchange (ETDEWEB)

    Daguzan, J.F

    2004-09-15

    This article uses the Iraq war major event to analyze the approach used by the US to fight against proliferation. It questions the decision and analysis process which has led to the US-British intervention and analyzes the consequences of the war on the proliferation of other countries and on the expected perspectives. Finally, the future of proliferation itself is questioned: do we have to fear more threat or is the virtuous circle of non-proliferation well started? (J.S.)

  5. Neuronal models for evaluation of proliferation in vitro using high content screening

    International Nuclear Information System (INIS)

    Mundy, William R.; Radio, Nicholas M.; Freudenrich, Theresa M.

    2010-01-01

    In vitro test methods can provide a rapid approach for the screening of large numbers of chemicals for their potential to produce toxicity (hazard identification). In order to identify potential developmental neurotoxicants, a battery of in vitro tests for neurodevelopmental processes such as cell proliferation, differentiation, growth, and synaptogenesis has been proposed. The development of in vitro approaches for toxicity testing will require choosing a model system that is appropriate to the endpoint of concern. This study compared several cell lines as models for neuronal proliferation. The sensitivities of neuronal cell lines derived from three species (PC12, rat; N1E-115, mouse; SH-SY5Y, human) to chemicals known to affect cell proliferation were assessed using a high content screening system. After optimizing conditions for cell growth in 96-well plates, proliferation was measured as the incorporation of 5-bromo-2'-deoxyuridine (BrdU) into replicating DNA during S phase. BrdU-labeled cells were detected by immunocytochemistry and cell counts were obtained using automated image acquisition and analysis. The three cell lines showed approximately 30-40% of the population in S phase after a 4 h pulse of BrdU. Exposure to the DNA polymerase inhibitor aphidicolin for 20 h prior to the 4 h pulse of BrdU significantly decreased proliferation in all three cell lines. The sensitivities of the cell lines were compared by exposure to eight chemicals known to affect proliferation (positive controls) and determination of the concentration inhibiting proliferation by 50% of control (I 50 ). PC12 cells were the most sensitive to chemicals; 6 out of 8 chemicals (aphidicolin, cadmium, cytosine arabinoside, dexamethasone, 5-fluorouracil, and methylmercury) inhibited proliferation at the concentrations tested. SH-SY5Y cells were somewhat less sensitive to chemical effects, with five out of eight chemicals inhibiting proliferation; dexamethasone had no effect, and cadmium

  6. Serotonin regulates osteoblast proliferation and function in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Dai, S.Q.; Yu, L.P. [Department of Orthopedic Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu (China); Shi, X. [Department of Obstetrics and Gynecology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu (China); Wu, H. [Emergency Department, The First Affiliated Hospital, Soochow University, Suzhou (China); Shao, P.; Yin, G.Y.; Wei, Y.Z. [Department of Orthopedic Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu (China)

    2014-08-01

    The monoamine serotonin (5-hydroxytryptamine, 5-HT), a well-known neurotransmitter, also has important functions outside the central nervous system. The objective of this study was to investigate the role of 5-HT in the proliferation, differentiation, and function of osteoblasts in vitro. We treated rat primary calvarial osteoblasts with various concentrations of 5-HT (1 nM to 10 µM) and assessed the rate of osteoblast proliferation, expression levels of osteoblast-specific proteins and genes, and the ability to form mineralized nodules. Next, we detected which 5-HT receptor subtypes were expressed in rat osteoblasts at different stages of osteoblast differentiation. We found that 5-HT could inhibit osteoblast proliferation, differentiation, and mineralization at low concentrations, but this inhibitory effect was mitigated at relatively high concentrations. Six of the 5-HT receptor subtypes (5-HT{sub 1A}, 5-HT{sub 1B}, 5-HT{sub 1D}, 5-HT{sub 2A}, 5-HT{sub 2B}, and 5-HT{sub 2C}) were found to exist in rat osteoblasts. Of these, 5-HT{sub 2A} and 5-HT{sub 1B} receptors had the highest expression levels, at both early and late stages of differentiation. Our results indicated that 5-HT can regulate osteoblast proliferation and function in vitro.

  7. The challenges of nuclear proliferation

    International Nuclear Information System (INIS)

    Le Guelte, Georges

    2015-01-01

    The author of this article first outlines that the Non Proliferation Treaty (NPT) is a tool of domination used by nuclear powers: they can keep and even develop their own nuclear arsenal, while other countries who sign this treaty commit themselves not to try to acquire nuclear weapons. The USA and USSR kept on persuading various countries to sign this treaty, but eventually let some countries develop their military nuclear programme (Israel, Pakistan, or India). He evokes technical difficulties in the application of the Treaty, notably for the control of centrifugation activities. He outlines that the USA have now a dominant position with respect to this Treaty and its application, but that the Treaty remains a major safety element for the world. He evokes more recent and negative evolutions: the withdrawal of North Korea from the Treaty, the destruction of an Iraqi nuclear reactor by Israel (i.e. the destruction of a nuclear installation belonging to a country who signed the NPT by a country who did not sign it). He proposes an overview of the Iranian issue (history of the Iranian nuclear programme, of the nuclear crisis, of the still going on negotiations), and describes what could be the worst possible scenario

  8. North Korea: a mercenary proliferator?

    International Nuclear Information System (INIS)

    Hemez, Remy

    2015-01-01

    After having recalled that North Korea possesses a rather advanced ballistic programme which has been started in the 1970 with the Chinese support, that North Korea is the fourth world producer of ballistic missiles, the author outlines that this country has become a major proliferator as it exports this production to different States and non-State actors. He recalls the long history of relationships between North Korea and terrorist organisations (even during the Cold War), comments the current and major support of North Korea to Hamas and Hezbollah in Gaza and in Lebanon. These relationships are then related with those these both organisations have with Syria and Iran who are in fact the relays between them and North Korea. The author explains why Hamas and Hezbollah must buy their weapons to such a far country: Iran is submitted to international sanctions, Iran and Syria want to avoid being banned from the international community for selling weapon to a terrorist (or so-said) organisation, and prices are rather competitive. If North Korea is also submitted to international sanctions, weapon smuggling seems to be institutional in this country. The author finally briefly evokes the issue of chemical weapons: North Korea possesses few thousand tonnes of these weapons, and could export them to non-state organisations

  9. Director`s series on proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, K.C.; Price, M.E. [eds.

    1995-11-17

    This is an occasional publication of essays on the topics of nuclear, chemical, biological, and missile proliferation. The views represented are those of the author`s. Essay topics include: Nuclear Proliferation: Myth and Reality; Problems of Enforcing Compliance with Arms Control Agreements; The Unreliability of the Russian Officer Corps: Reluctant Domestic Warriors; and Russia`s Nuclear Legacy.

  10. Cell proliferation and radiosensitivity of cow lymphocytes in culture

    International Nuclear Information System (INIS)

    Modave, C.; Fabry, L.; Leonard, A.

    1982-01-01

    The harlequin-staining technique has been used to study, after PHA-stimulation, the cell proliferation of cow lymphocytes in culture and to assess the radiosensitivity in first mitosis cells. At the 48 h fixation time, only 34% of the cells are in first mitosis whereas 55% are already in second and 11% in third mitosis. The exposure of cow lymphocytes to 200 rad X-rays result in the production of 16% dicentric chromosomes in first mitosis cells [fr

  11. Forces in Motzkin paths in a wedge

    International Nuclear Information System (INIS)

    Janse van Rensburg, E J

    2006-01-01

    Entropic forces in models of Motzkin paths in a wedge geometry are considered as models of forces in polymers in confined geometries. A Motzkin path in the square lattice is a path from the origin to a point in the line Y = X while it never visits sites below this line, and it is constrained to give unit length steps only in the north and east directions and steps of length √2 in the north-east direction. Motzkin path models may be generalized to ensembles of NE-oriented paths above the line Y = rX, where r > 0 is an irrational number. These are paths giving east, north and north-east steps from the origin in the square lattice, and confined to the r-wedge formed by the Y-axis and the line Y = rX. The generating function g r of these paths is not known, but if r > 1, then I determine its radius of convergence to be t r = min (r-1)/r≤y≤r/(r+1) [y y (1-r(1-y)) 1-r(1-y) (r(1-y)-y) r(1-y)-y ] and if r is an element of (0, 1), then t r = 1/3. The entropic force the path exerts on the line Y rX may be computed from this. An asymptotic expression for the force for large values of r is given by F(r) = log(2r)/r 2 - (1+2log(2r))/2r 3 + O (log(2r)/r 4 ). In terms of the vertex angle α of the r-wedge, the moment of the force about the origin has leading terms F(α) log(2/α) - (α/2)(1+2log(2/α)) + O(α 2 log(2/α)) as α → 0 + and F(α) = 0 if α is element of [π/4, π/2]. Moreover, numerical integration of the force shows that the total work done by closing the wedge is 1.085 07... lattice units. An alternative ensemble of NE-oriented paths may be defined by slightly changing the generating function g r . In this model, it is possible to determine closed-form expressions for the limiting free energy and the force. The leading term in an asymptotic expansions for this force agrees with the leading term in the asymptotic expansion of the above model, and the subleading term only differs by a factor of 2

  12. Association of manual or engine-driven glide path preparation with canal centring and apical transportation: a systematic review.

    Science.gov (United States)

    Hartmann, R C; Peters, O A; de Figueiredo, J A P; Rossi-Fedele, G

    2018-04-28

    The role and effect of glide path preparation in root canal treatment remain controversial. This systematic review aims to compare apical transportation and canal centring of different glide path preparation techniques, with or without subsequent engine-driven root canal preparation. A database search in PubMed, PubMed Central, Embase, Scopus, EBSCO Dentistry & Oral Sciences Source and Virtual Health Library was conducted, using appropriate key words to identify the effect of glide path preparation (or its absence) on apical transportation and canal centring. An assessment for the risk of bias in included studies was carried out. Amongst 2146 studies, 18 satisfied the inclusion criteria. Nine studies assessed glide path preparation per se, comparing apical transportation and canal centring of rotary systems and/or manual files; eleven further investigations examined the efficacy of the glide path prior to final canal preparation with different engine-driven systems. Risk of bias and other study design features with potential influence on study outcomes and clinical implications were assessed. Based on the available evidence, and within the limitation of the studies included, preparation of a glide path using rotary sequences performs similarly (in most of the component studies) or significantly better than manual preparation when assessing apical transportation or canal centring. When compared to the absence of a glide path, canal shaping following glide path preparation was of similar, or significantly better quality, in regard to apical transportation or canal centring. © 2018 International Endodontic Journal. Published by John Wiley & Sons Ltd.

  13. Path optimization method for the sign problem

    Directory of Open Access Journals (Sweden)

    Ohnishi Akira

    2018-01-01

    Full Text Available We propose a path optimization method (POM to evade the sign problem in the Monte-Carlo calculations for complex actions. Among many approaches to the sign problem, the Lefschetz-thimble path-integral method and the complex Langevin method are promising and extensively discussed. In these methods, real field variables are complexified and the integration manifold is determined by the flow equations or stochastically sampled. When we have singular points of the action or multiple critical points near the original integral surface, however, we have a risk to encounter the residual and global sign problems or the singular drift term problem. One of the ways to avoid the singular points is to optimize the integration path which is designed not to hit the singular points of the Boltzmann weight. By specifying the one-dimensional integration-path as z = t +if(t(f ϵ R and by optimizing f(t to enhance the average phase factor, we demonstrate that we can avoid the sign problem in a one-variable toy model for which the complex Langevin method is found to fail. In this proceedings, we propose POM and discuss how we can avoid the sign problem in a toy model. We also discuss the possibility to utilize the neural network to optimize the path.

  14. The formal path integral and quantum mechanics

    International Nuclear Information System (INIS)

    Johnson-Freyd, Theo

    2010-01-01

    Given an arbitrary Lagrangian function on R d and a choice of classical path, one can try to define Feynman's path integral supported near the classical path as a formal power series parameterized by 'Feynman diagrams', although these diagrams may diverge. We compute this expansion and show that it is (formally, if there are ultraviolet divergences) invariant under volume-preserving changes of coordinates. We prove that if the ultraviolet divergences cancel at each order, then our formal path integral satisfies a 'Fubini theorem' expressing the standard composition law for the time evolution operator in quantum mechanics. Moreover, we show that when the Lagrangian is inhomogeneous quadratic in velocity such that its homogeneous-quadratic part is given by a matrix with constant determinant, then the divergences cancel at each order. Thus, by 'cutting and pasting' and choosing volume-compatible local coordinates, our construction defines a Feynman-diagrammatic 'formal path integral' for the nonrelativistic quantum mechanics of a charged particle moving in a Riemannian manifold with an external electromagnetic field.

  15. Perfect discretization of reparametrization invariant path integrals

    International Nuclear Information System (INIS)

    Bahr, Benjamin; Dittrich, Bianca; Steinhaus, Sebastian

    2011-01-01

    To obtain a well-defined path integral one often employs discretizations. In the case of gravity and reparametrization-invariant systems, the latter of which we consider here as a toy example, discretizations generically break diffeomorphism and reparametrization symmetry, respectively. This has severe implications, as these symmetries determine the dynamics of the corresponding system. Indeed we will show that a discretized path integral with reparametrization-invariance is necessarily also discretization independent and therefore uniquely determined by the corresponding continuum quantum mechanical propagator. We use this insight to develop an iterative method for constructing such a discretized path integral, akin to a Wilsonian RG flow. This allows us to address the problem of discretization ambiguities and of an anomaly-free path integral measure for such systems. The latter is needed to obtain a path integral, that can act as a projector onto the physical states, satisfying the quantum constraints. We will comment on implications for discrete quantum gravity models, such as spin foams.

  16. Perfect discretization of reparametrization invariant path integrals

    Science.gov (United States)

    Bahr, Benjamin; Dittrich, Bianca; Steinhaus, Sebastian

    2011-05-01

    To obtain a well-defined path integral one often employs discretizations. In the case of gravity and reparametrization-invariant systems, the latter of which we consider here as a toy example, discretizations generically break diffeomorphism and reparametrization symmetry, respectively. This has severe implications, as these symmetries determine the dynamics of the corresponding system. Indeed we will show that a discretized path integral with reparametrization-invariance is necessarily also discretization independent and therefore uniquely determined by the corresponding continuum quantum mechanical propagator. We use this insight to develop an iterative method for constructing such a discretized path integral, akin to a Wilsonian RG flow. This allows us to address the problem of discretization ambiguities and of an anomaly-free path integral measure for such systems. The latter is needed to obtain a path integral, that can act as a projector onto the physical states, satisfying the quantum constraints. We will comment on implications for discrete quantum gravity models, such as spin foams.

  17. Increased synthesis of heparin affin regulatory peptide in the perforant path lesioned mouse hippocampal formation

    DEFF Research Database (Denmark)

    Poulsen, F R; Lagord, C; Courty, J

    2000-01-01

    Heparin affin regulatory peptide (HARP), also known as pleiotrophin or heparin-binding growth-associated molecule, is a developmentally regulated extracellular matrix protein that induces cell proliferation and promotes neurite outgrowth in vitro as well as pre- and postsynaptic developmental...... differentiation in vivo. Here we have investigated the expression of HARP mRNA and protein in the perforant path lesioned C57B1/6 mouse hippocampal formation from 1 to 35 days after surgery. This type of lesion induces a dense anterograde and terminal axonal degeneration, activation of glial cells, and reactive...... axonal sprouting within the perforant path zones of the fascia dentata and hippocampus as well as axotomy-induced retrograde neuronal degeneration in the entorhinal cortex. Analysis of sham- and unoperated control mice showed that HARP mRNA is expressed in neurons and white and gray matter glial cells...

  18. Combining control input with flight path data to evaluate pilot performance in transport aircraft.

    Science.gov (United States)

    Ebbatson, Matt; Harris, Don; Huddlestone, John; Sears, Rodney

    2008-11-01

    When deriving an objective assessment of piloting performance from flight data records, it is common to employ metrics which purely evaluate errors in flight path parameters. The adequacy of pilot performance is evaluated from the flight path of the aircraft. However, in large jet transport aircraft these measures may be insensitive and require supplementing with frequency-based measures of control input parameters. Flight path and control input data were collected from pilots undertaking a jet transport aircraft conversion course during a series of symmetric and asymmetric approaches in a flight simulator. The flight path data were analyzed for deviations around the optimum flight path while flying an instrument landing approach. Manipulation of the flight controls was subject to analysis using a series of power spectral density measures. The flight path metrics showed no significant differences in performance between the symmetric and asymmetric approaches. However, control input frequency domain measures revealed that the pilots employed highly different control strategies in the pitch and yaw axes. The results demonstrate that to evaluate pilot performance fully in large aircraft, it is necessary to employ performance metrics targeted at both the outer control loop (flight path) and the inner control loop (flight control) parameters in parallel, evaluating both the product and process of a pilot's performance.

  19. The thorny path linking cellular senescence to organismalaging

    Energy Technology Data Exchange (ETDEWEB)

    Patil, Christopher K.; Mian, Saira; Campisi, Judith

    2005-08-09

    Half a century is fast approaching since Hayflick and colleagues formally described the limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961). This finding--that normal somatic cells, in contrast to cancer cells, cannot divide indefinitely--challenged the prevailing idea that cells from mortal multicellular organisms were intrinsically ''immortal'' (Carrell, 1912). It also spawned two hypotheses, essential elements of which persist today. The first held that the restricted proliferation of normal cells, now termed cellular senescence, suppresses cancer (Hayflick, 1965; Sager, 1991; Campisi, 2001). The second hypothesis, as explained in the article by Lorenzini et al., suggested that the limited proliferation of cells in culture recapitulated aspects of organismal aging (Hayflick, 1965; Martin, 1993). How well have these hypotheses weathered the ensuing decades? Before answering this question, we first consider current insights into the causes and consequences of cellular senescence. Like Lorenzini et al., we limit our discussion to mammals. We also focus on fibroblasts, the cell type studied by Lorenzini et al., but consider other types as well. We suggest that replicative capacity in culture is not a straightforward assessment, and that it correlates poorly with both longevity and body mass. We speculate this is due to the malleable and variable nature of replicative capacity, which renders it an indirect metric of qualitative and quantitative differences among cells to undergo senescence, a response that directly alters cellular phenotype and might indirectly alter tissue structure and function.

  20. Paths to Licensure: Things Physicists Should Know

    Science.gov (United States)

    Stewart, Gay; Stewart, John

    2016-03-01

    The path to licensure can be quite complicated, and can thwart a physics department's efforts to produce more and better prepared high school physics teachers. Each state has different pathways to licensure. Acronyms like CAEP and SPA are not within the normal physicist's vocabulary. Some understanding of this topic can allow physics faculty advisers to help our students so that fewer are derailed on their path to the classroom, or take a path that will leave them less well prepared if they do find themselves there. Examples of different approaches that work within state licensure systems from two different states will be presented. Physics teacher preparation efforts in both Arkansas and West Virginia have been supported in part by the Physics Teacher Education Coalition (PhysTEC).

  1. A taxonomy of integral reaction path analysis

    Energy Technology Data Exchange (ETDEWEB)

    Grcar, Joseph F.; Day, Marcus S.; Bell, John B.

    2004-12-23

    W. C. Gardiner observed that achieving understanding through combustion modeling is limited by the ability to recognize the implications of what has been computed and to draw conclusions about the elementary steps underlying the reaction mechanism. This difficulty can be overcome in part by making better use of reaction path analysis in the context of multidimensional flame simulations. Following a survey of current practice, an integral reaction flux is formulated in terms of conserved scalars that can be calculated in a fully automated way. Conditional analyses are then introduced, and a taxonomy for bidirectional path analysis is explored. Many examples illustrate the resulting path analysis and uncover some new results about nonpremixed methane-air laminar jets.

  2. Path integral solution of the Dirichlet problem

    International Nuclear Information System (INIS)

    LaChapelle, J.

    1997-01-01

    A scheme for functional integration developed by Cartier/DeWitt-Morette is first reviewed and then employed to construct the path integral representation for the solution of the Dirichlet problem in terms of first exit time. The path integral solution is then applied to calculate the fixed-energy point-to-point transition amplitude both in configuration and phase space. The path integral solution can also be derived using physical principles based on Feynman close-quote s original reasoning. We check that the Fourier transform in energy of the fixed-energy point-to-point transition amplitude gives the well known time-dependent transition amplitude, and calculate the WKB approximation. copyright 1997 Academic Press, Inc

  3. Reaction path simulations in multicomponent materials

    International Nuclear Information System (INIS)

    Seifert, H.J.

    1999-01-01

    The CALPHAD (calculation of phase diagrams) method is used in combination with selected experimental investigations to derive reaction paths in multicomponent systems. The method is illustrated by applying computerized thermodynamic databases and suitable software to explain quantitatively the thermal degradation of precursor-derived Si-C-N ceramics and the nitridation of titanium carbide. Reaction sequences in the Si 3 N 4 -SiC-TiC x N l-x -C-N system are illustrated by graphical representation of compatibility regions and indicated reaction paths. From these results the experimentally known microstructure development of TiC reinforced Si 3 N 4 ceramics is explained and quantitative information is provided to optimize the microstructure of such materials. The concept of reaction paths for the understanding of rapid solidification processes is shown by the example of AZ type Mg casting alloys. (orig.)

  4. Approximate Shortest Homotopic Paths in Weighted Regions

    KAUST Repository

    Cheng, Siu-Wing

    2010-01-01

    Let P be a path between two points s and t in a polygonal subdivision T with obstacles and weighted regions. Given a relative error tolerance ε ∈(0,1), we present the first algorithm to compute a path between s and t that can be deformed to P without passing over any obstacle and the path cost is within a factor 1 + ε of the optimum. The running time is O(h 3/ε2 kn polylog(k, n, 1/ε)), where k is the number of segments in P and h and n are the numbers of obstacles and vertices in T, respectively. The constant in the running time of our algorithm depends on some geometric parameters and the ratio of the maximum region weight to the minimum region weight. © 2010 Springer-Verlag.

  5. Approximate shortest homotopic paths in weighted regions

    KAUST Repository

    Cheng, Siuwing

    2012-02-01

    A path P between two points s and t in a polygonal subdivision T with obstacles and weighted regions defines a class of paths that can be deformed to P without passing over any obstacle. We present the first algorithm that, given P and a relative error tolerance ε (0, 1), computes a path from this class with cost at most 1 + ε times the optimum. The running time is O(h 3/ε 2kn polylog (k,n,1/ε)), where k is the number of segments in P and h and n are the numbers of obstacles and vertices in T, respectively. The constant in the running time of our algorithm depends on some geometric parameters and the ratio of the maximum region weight to the minimum region weight. © 2012 World Scientific Publishing Company.

  6. Chronic hypoxia promotes pulmonary artery endothelial cell proliferation through H2O2-induced 5-lipoxygenase.

    Directory of Open Access Journals (Sweden)

    Kristi M Porter

    Full Text Available Pulmonary Hypertension (PH is a progressive disorder characterized by endothelial dysfunction and proliferation. Hypoxia induces PH by increasing vascular remodeling. A potential mediator in hypoxia-induced PH development is arachidonate 5-Lipoxygenase (ALOX5. While ALOX5 metabolites have been shown to promote pulmonary vasoconstriction and endothelial cell proliferation, the contribution of ALOX5 to hypoxia-induced proliferation remains unknown. We hypothesize that hypoxia exposure stimulates HPAEC proliferation by increasing ALOX5 expression and activity. To test this, human pulmonary artery endothelial cells (HPAEC were cultured under normoxic (21% O2 or hypoxic (1% O2 conditions for 24-, 48-, or 72 hours. In a subset of cells, the ALOX5 inhibitor, zileuton, or the 5-lipoxygenase activating protein inhibitor, MK-886, was administered during hypoxia exposure. ALOX5 expression was measured by qRT-PCR and western blot and HPAEC proliferation was assessed. Our results demonstrate that 24 and 48 hours of hypoxia exposure have no effect on HPAEC proliferation or ALOX5 expression. Seventy two hours of hypoxia significantly increases HPAEC ALOX5 expression, hydrogen peroxide (H2O2 release, and HPAEC proliferation. We also demonstrate that targeted ALOX5 gene silencing or inhibition of the ALOX5 pathway by pharmacological blockade attenuates hypoxia-induced HPAEC proliferation. Furthermore, our findings indicate that hypoxia-induced increases in cell proliferation and ALOX5 expression are dependent on H2O2 production, as administration of the antioxidant PEG-catalase blocks these effects and addition of H2O2 to HPAEC promotes proliferation. Overall, these studies indicate that hypoxia exposure induces HPAEC proliferation by activating the ALOX5 pathway via the generation of H2O2.

  7. The effect of solar and lunar currents on simultaneous phase path, group path and amplitude measurements

    International Nuclear Information System (INIS)

    Baulch, R.N.E.; Butcher, E.C.

    1984-01-01

    The solar and lunar variations in the phase path, group path and amplitude of a fixed frequency transmission were obtained at the September equinox over a slightly oblique path. The phase of the lunar semi-diurnal tide in the phase path and amplitude were similar, the maxima occurring near 0200 lunar time, whereas the group path had a maximum near 0800 lunar time. These results were compared with other results obtained near the same location. The results suggest a complex situation in the E-region, where the height of the lunar current depends on season, and also suggest that the location and distribution of the solar and lunar currents may be different. (author)

  8. The non-proliferation experiment

    Energy Technology Data Exchange (ETDEWEB)

    Hannon, W.J. [Lawrence Livermore National Lab., CA (United States)

    1994-12-31

    On September 22, 1993, the Department of Energy detonated more than 1.2 million kg of blasting agent in a tunnel in Rainier Mesa at the Nevada Test Site. The resulting explosion generated seismic, electromagnetic, and air pressure signals that were recorded on instruments deployed at distances ranging from a few meters to hundreds and, in some cases, thousands of kilometers. More than 12 organizations made measurements before, during, and after the explosions. The explosion and its associated experiments are known as the Non-Proliferation Experiment (NPE). Analyses of the measurements made during the NPE and comparisons with similar measurements made on previous nearly nuclear explosions and on a co-located smaller explosion detonated at the same site are providing basic phenomenological insights into what is potentially one of the comprehensive Test Ban Treaty (CTBT)-distinguishing between nuclear explosions and some of the many conventional explosions that occur each year. The NPE is also providing information on the use of chemical explosions to develop empirical discriminants in regions where no nuclear explosions have been recorded. In another verification application, several NPE projects are examining the utility of on-site, pre-shot, shot-time, and post-shot measurements of gas seepage, seismic activity, and other observables as a means of identifying the source of signals that appear like nuclear explosions at regional distances. Two related activities are being considered. First, challenge on-site inspections, conducted after an event has occurred, may be able to use the characteristics of phenomena that persist after the explosion to detect and identify the source of the signals that appeared ambiguous or explosion-like to remote sensors. Second, cooperative, on-site measurements made at the time of a pre-nounced conventional explosion may provide assurance that a nuclear explosion did not occur as part of or in place of the pre-announced explosion.

  9. Tornado intensity estimated from damage path dimensions.

    Directory of Open Access Journals (Sweden)

    James B Elsner

    Full Text Available The Newcastle/Moore and El Reno tornadoes of May 2013 are recent reminders of the destructive power of tornadoes. A direct estimate of a tornado's power is difficult and dangerous to get. An indirect estimate on a categorical scale is available from a post-storm survery of the damage. Wind speed bounds are attached to the scale, but the scale is not adequate for analyzing trends in tornado intensity separate from trends in tornado frequency. Here tornado intensity on a continuum is estimated from damage path length and width, which are measured on continuous scales and correlated to the EF rating. The wind speeds on the EF scale are treated as interval censored data and regressed onto the path dimensions and fatalities. The regression model indicates a 25% increase in expected intensity over a threshold intensity of 29 m s(-1 for a 100 km increase in path length and a 17% increase in expected intensity for a one km increase in path width. The model shows a 43% increase in the expected intensity when fatalities are observed controlling for path dimensions. The estimated wind speeds correlate at a level of .77 (.34, .93 [95% confidence interval] with a small sample of wind speeds estimated independently from a doppler radar calibration. The estimated wind speeds allow analyses to be done on the tornado database that are not possible with the categorical scale. The modeled intensities can be used in climatology and in environmental and engineering applications. Research is needed to understand the upward trends in path length and width.

  10. Tornado intensity estimated from damage path dimensions.

    Science.gov (United States)

    Elsner, James B; Jagger, Thomas H; Elsner, Ian J

    2014-01-01

    The Newcastle/Moore and El Reno tornadoes of May 2013 are recent reminders of the destructive power of tornadoes. A direct estimate of a tornado's power is difficult and dangerous to get. An indirect estimate on a categorical scale is available from a post-storm survery of the damage. Wind speed bounds are attached to the scale, but the scale is not adequate for analyzing trends in tornado intensity separate from trends in tornado frequency. Here tornado intensity on a continuum is estimated from damage path length and width, which are measured on continuous scales and correlated to the EF rating. The wind speeds on the EF scale are treated as interval censored data and regressed onto the path dimensions and fatalities. The regression model indicates a 25% increase in expected intensity over a threshold intensity of 29 m s(-1) for a 100 km increase in path length and a 17% increase in expected intensity for a one km increase in path width. The model shows a 43% increase in the expected intensity when fatalities are observed controlling for path dimensions. The estimated wind speeds correlate at a level of .77 (.34, .93) [95% confidence interval] with a small sample of wind speeds estimated independently from a doppler radar calibration. The estimated wind speeds allow analyses to be done on the tornado database that are not possible with the categorical scale. The modeled intensities can be used in climatology and in environmental and engineering applications. Research is needed to understand the upward trends in path length and width.

  11. Which coordinate system for modelling path integration?

    Science.gov (United States)

    Vickerstaff, Robert J; Cheung, Allen

    2010-03-21

    Path integration is a navigation strategy widely observed in nature where an animal maintains a running estimate, called the home vector, of its location during an excursion. Evidence suggests it is both ancient and ubiquitous in nature, and has been studied for over a century. In that time, canonical and neural network models have flourished, based on a wide range of assumptions, justifications and supporting data. Despite the importance of the phenomenon, consensus and unifying principles appear lacking. A fundamental issue is the neural representation of space needed for biological path integration. This paper presents a scheme to classify path integration systems on the basis of the way the home vector records and updates the spatial relationship between the animal and its home location. Four extended classes of coordinate systems are used to unify and review both canonical and neural network models of path integration, from the arthropod and mammalian literature. This scheme demonstrates analytical equivalence between models which may otherwise appear unrelated, and distinguishes between models which may superficially appear similar. A thorough analysis is carried out of the equational forms of important facets of path integration including updating, steering, searching and systematic errors, using each of the four coordinate systems. The type of available directional cue, namely allothetic or idiothetic, is also considered. It is shown that on balance, the class of home vectors which includes the geocentric Cartesian coordinate system, appears to be the most robust for biological systems. A key conclusion is that deducing computational structure from behavioural data alone will be difficult or impossible, at least in the absence of an analysis of random errors. Consequently it is likely that further theoretical insights into path integration will require an in-depth study of the effect of noise on the four classes of home vectors. Copyright 2009 Elsevier Ltd

  12. Path to a Research Plan

    Science.gov (United States)

    Chiaramonte, Fran

    2003-01-01

    working groups, the BPRAC subcommittees, and with the BPRAC. Recommendations from NRC past and current committees will be implemented whenever appropriate.Proposed theme element content will be "missionized" around planned content and potential new projects (facilities, modules, initiatives) on approximately a five-year horizon, with the approval of PSRD management. Center/science working group teams will develop descriptions of "mission" objectives, value, and requirements. Purpose is to create a competitive environment for concept development and to stimulate community ownership/advocacy. Proposed theme elements reviewed and approved by PSRD management. Strawman roadmaps for themes developed. Program budget and technology requirements verified. Theme elements are prioritized with the input of advisory groups. Integration into program themes (questions) and required technology investments are defined by science and technology roadmaps. Review and assessment by OBPR management.

  13. The transformation techniques in path integration

    International Nuclear Information System (INIS)

    Inomata, A.

    1989-01-01

    In this paper general remarks are made concerning the time transformation techniques in path integration and their implementations. Time transformations may be divided into two classes: global (integrable) time transformations and local (nonintegrable) time transformations. Although a brief account of global time transformations is given, attention is focused on local transformations. First, time transformations in the classical Kepler problem are reviewed. Then, problems encountered in implementing a local time transformation in quantum mechanics are analyzed. A several propositions pertinent to the implementation of local time transformations, particularly basic to the local time rescaling trick in a discretized path integral, are presented

  14. Flight Path Recovery System (FPRS) design study

    Energy Technology Data Exchange (ETDEWEB)

    1978-09-01

    The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented.

  15. Canonical transformations and hamiltonian path integrals

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1982-01-01

    Behaviour of the Hamiltonian path integrals under canonical transformations produced by a generator, is investigated. An exact form is determined for the kernel of the unitary operator realizing the corresponding quantum transformation. Equivalence rules are found (the Hamiltonian formalism, one-dimensional case) enabling one to exclude non-standard terms from the action. It is shown that the Hamiltonian path integral changes its form under cononical transformations: in the transformed expression besides the classical Hamiltonian function there appear some non-classical terms

  16. Flight Path Recovery System (FPRS) design study

    International Nuclear Information System (INIS)

    1978-09-01

    The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented

  17. Field theory a path integral approach

    CERN Document Server

    Das, Ashok

    2006-01-01

    This unique book describes quantum field theory completely within the context of path integrals. With its utility in a variety of fields in physics, the subject matter is primarily developed within the context of quantum mechanics before going into specialized areas.Adding new material keenly requested by readers, this second edition is an important expansion of the popular first edition. Two extra chapters cover path integral quantization of gauge theories and anomalies, and a new section extends the supersymmetry chapter, where singular potentials in supersymmetric systems are described.

  18. Cross-interference of two model peroxisome proliferators in peroxisomal and estrogenic pathways in brown trout hepatocytes.

    Science.gov (United States)

    Madureira, Tânia Vieira; Pinheiro, Ivone; Malhão, Fernanda; Lopes, Célia; Urbatzka, Ralph; Castro, L Filipe C; Rocha, Eduardo

    2017-06-01

    Peroxisome proliferators cause species-specific effects, which seem to be primarily transduced by peroxisome proliferator-activated receptor alpha (PPARα). Interestingly, PPARα has a close interrelationship with estrogenic signaling, and this latter has already been promptly activated in brown trout primary hepatocytes. Thus, and further exploring this model, we assess here the reactivity of two PPARα agonists in direct peroxisomal routes and, in parallel the cross-interferences in estrogen receptor (ER) mediated paths. To achieve these goals, three independent in vitro studies were performed using single exposures to clofibrate - CLF (50, 500 and 1000μM), Wy-14,643 - Wy (50 and 150μM), GW6471 - GW (1 and 10μM), and mixtures, including PPARα agonist or antagonist plus an ER agonist or antagonist. Endpoints included gene expression analysis of peroxisome/lipidic related genes (encoding apolipoprotein AI - ApoAI, fatty acid binding protein 1 - Fabp1, catalase - Cat, 17 beta-hydroxysteroid dehydrogenase 4 - 17β-HSD4, peroxin 11 alpha - Pex11α, PPARαBb, PPARαBa and urate oxidase - Uox) and those encoding estrogenic targets (ERα, ERβ-1 and vitellogenin A - VtgA). A quantitative morphological approach by using a pre-validated catalase immunofluorescence technique allowed checking possible changes in peroxisomes. Our results show a low responsiveness of trout hepatocytes to model PPARα agonists in direct target receptor pathways. Additionally, we unveiled interferences in estrogenic signaling caused by Wy, leading to an up-regulation VtgA and ERα at 150μM; these effects seem counteracted with a co-exposure to an ER antagonist. The present data stress the potential of this in vitro model for further exploring the physiological/toxicological implications related with this nuclear receptor cross-regulation. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Graphs with not all possible path-kernels

    DEFF Research Database (Denmark)

    Aldred, Robert; Thomassen, Carsten

    2004-01-01

    The Path Partition Conjecture states that the vertices of a graph G with longest path of length c may be partitioned into two parts X and Y such that the longest path in the subgraph of G induced by X has length at most a and the longest path in the subgraph of G induced by Y has length at most b...

  20. Nuclear proliferation: prospects, problems, and proposals

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    This issue of the ANNALS addresses itself to three aspects of nuclear proliferation: the prospect that new nuclear powers will come on the scene, the problems that their arrival may create, and ways of coping with those problems. In an introductory paper, ''Quo Vadimus,'' Joseph I. Coffey investigates the pros and cons of proliferation, concluding that it is not a question of whether there will be nuclear proliferation, but in what countries. Part I, Where We Are, contains five papers preceded by introductory comments by Joseph I. Coffey. The papers and their authors are: Why States Go--and Don't Go--Nuclear, William Epstein; How States Can ''Go Nuclear,'' Frank C. Barnaby; What Happens If. . .Terrorists, Revolutionaries, and Nuclear Weapons, David Kreiger; Safeguards Against Diversion of Nuclear Material: An Overview, Ryukichi Imai; and Reducing the Incentives to Proliferation, George H. Quester. Part II, And Where We May Go, again includes some introductory remarks by Joseph I. Coffey. The seven succeeding papers are: Nth Powers of the Future, Ashok Kapur; Nuclear Proliferation and World Politics, Lewis A. Dunn; Arms Control in a Nuclear Armed World, Colin Gray; The United Nations, the Superpowers, and Proliferation, Abraham Bargman; Proliferation and the Future: Destruction or Transformation, Frederick C. Thayer; Decision Making in a Nuclear Armed World, Michael Brenner; and The United States in a World of Nuclear Powers, Michael Nacht. This special report is concluded with a glossary

  1. Which future for nuclear counter-proliferation?

    International Nuclear Information System (INIS)

    Duval, M.

    2010-01-01

    Dealing with the case of nuclear weapons possessed by nuclear states (but not eventually by terrorists), the author first identifies the constants of counter-proliferation: it is linked to interest conflicts between those who try to preserve their monopoly and those who try to acquire a new weapon either because of a threat or for reasons of regional prestige, the evolution from use to deterrence, the appearance of new actors after the USA and Russia, the role of nuclear tactical weapons, and the future of Russian weapons and know-how. He presents the international counter-proliferation context: the Non Proliferation Treaty (NPT), the IAEA and its controls, the Nuclear Supplier Group (NSG), the nuclear-free zones, the Comprehensive Test Ban Treaty (CTBT), the Missile Technology Control Regime (MTCR). He describes how and why proliferation occurs: uranium enrichment and plutonium technology, political reasons in different parts of the world. Then, he gives an overview of the proliferation status by commenting the cases of Israel, Iraq, India, Pakistan, North Korea, and Iran. He discusses the future of proliferation (involved countries, existence of a nuclear black market) and of counter-proliferation as far as Middle-East and North Korea are concerned. He tries finally to anticipate the consequences for nuclear deterrence strategy, and more particularly for Europe and France

  2. Harmine stimulates proliferation of human neural progenitors

    Directory of Open Access Journals (Sweden)

    Vanja Dakic

    2016-12-01

    Full Text Available Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A, which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY, and an irreversible selective inhibitor of monoamine oxidase (MAO but not DYRK1A (pargyline. INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo.

  3. Walking path-planning method for multiple radiation areas

    International Nuclear Information System (INIS)

    Liu, Yong-kuo; Li, Meng-kun; Peng, Min-jun; Xie, Chun-li; Yuan, Cheng-qian; Wang, Shuang-yu; Chao, Nan

    2016-01-01

    Highlights: • Radiation environment modeling method is designed. • Path-evaluating method and segmented path-planning method are proposed. • Path-planning simulation platform for radiation environment is built. • The method avoids to be misled by minimum dose path in single area. - Abstract: Based on minimum dose path-searching method, walking path-planning method for multiple radiation areas was designed to solve minimum dose path problem in single area and find minimum dose path in the whole space in this paper. Path-planning simulation platform was built using C# programming language and DirectX engine. The simulation platform was used in simulations dealing with virtual nuclear facilities. Simulation results indicated that the walking-path planning method is effective in providing safety for people walking in nuclear facilities.

  4. A low complexity method for the optimization of network path length in spatially embedded networks

    International Nuclear Information System (INIS)

    Chen, Guang; Yang, Xu-Hua; Xu, Xin-Li; Ming, Yong; Chen, Sheng-Yong; Wang, Wan-Liang

    2014-01-01

    The average path length of a network is an important index reflecting the network transmission efficiency. In this paper, we propose a new method of decreasing the average path length by adding edges. A new indicator is presented, incorporating traffic flow demand, to assess the decrease in the average path length when a new edge is added during the optimization process. With the help of the indicator, edges are selected and added into the network one by one. The new method has a relatively small time computational complexity in comparison with some traditional methods. In numerical simulations, the new method is applied to some synthetic spatially embedded networks. The result shows that the method can perform competitively in decreasing the average path length. Then, as an example of an application of this new method, it is applied to the road network of Hangzhou, China. (paper)

  5. Non-proliferation and multinational enterprises

    International Nuclear Information System (INIS)

    1979-04-01

    The paper supplements CC/WG.2/9 in presenting the Japanese delegation's contribution in the areas of non-proliferation and multi-national enterprises. The paper questions whether multinational enrichment enterprises would constitute a significant non-proliferation factor, noting that the nature of the venture might create a potential for the dissemination of sensitive information. The paper also argues that a multi-national venture which was not economically competitive (with national facilities) would have questionable viability. The conclusion is that non-proliferation advantages, if any, would be a result, not an objective of such a venture

  6. On the structure of path-like trees

    OpenAIRE

    Muntaner Batle, Francesc Antoni; Rius Font, Miquel

    2007-01-01

    We study the structure of path-like trees. In order to do this, we introduce a set of trees that we call expandable trees. In this paper we also generalize the concept of path-like trees and we call such generalization generalized path-like trees. As in the case of path-like trees, generalized path-like trees, have very nice labeling properties.

  7. Preliminary analysis of alternative fuel cycles for proliferation evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M. J.; Ripfel, H. C.F.; Rainey, R. H.

    1977-01-01

    The ERDA Division of Nuclear Research and Applications proposed 67 nuclear fuel cycles for assessment as to their nonproliferation potential. The object of the assessment was to determine which fuel cycles pose inherently low risk for nuclear weapon proliferation while retaining the major benefits of nuclear energy. This report is a preliminary analysis of these fuel cycles to develop the fuel-recycle data that will complement reactor data, environmental data, and political considerations, which must be included in the overall evaluation. This report presents the preliminary evaluations from ANL, HEDL, ORNL, and SRL and is the basis for a continuing in-depth study. (DLC)

  8. Propagation Effects in Space/Earth Paths.

    Science.gov (United States)

    1980-08-01

    0 h In both integrals ds is a differential of curved ray path and includes refractive bending. In either integral, the factor aTar is, by the Rayleigh...interference. Ionospheric modification may also result from the emission of exhaust effluents from HLLV’s. The associated changes in ionospherio chemistry can

  9. Learning to improve path planning performance

    International Nuclear Information System (INIS)

    Chen, Pang C.

    1995-04-01

    In robotics, path planning refers to finding a short. collision-free path from an initial robot configuration to a desired configuratioin. It has to be fast to support real-time task-level robot programming. Unfortunately, current planning techniques are still too slow to be effective, as they often require several minutes, if not hours of computation. To remedy this situation, we present and analyze a learning algorithm that uses past experience to increase future performance. The algorithm relies on an existing path planner to provide solutions to difficult tasks. From these solutions, an evolving sparse network of useful robot configurations is learned to support faster planning. More generally, the algorithm provides a speedup-learning framework in which a slow but capable planner may be improved both cost-wise and capability-wise by a faster but less capable planner coupled with experience. The basic algorithm is suitable for stationary environments, and can be extended to accommodate changing environments with on-demand experience repair and object-attached experience abstraction. To analyze the algorithm, we characterize the situations in which the adaptive planner is useful, provide quantitative bounds to predict its behavior, and confirm our theoretical results with experiments in path planning of manipulators. Our algorithm and analysis are sufficiently, general that they may also be applied to other planning domains in which experience is useful

  10. Gender Differences in Career Paths in Banking.

    Science.gov (United States)

    Morgan, Sandra; And Others

    1993-01-01

    Analyzed career paths of middle managers in bank. Study of matched pairs found that men (n=25) advanced faster and reached middle management through fewer promotions and positions than did women (n=25). Men had significantly more work experience outside of banking. In banking careers, men held more jobs in lending, whereas women occupied more…

  11. Quad-rotor flight path energy optimization

    Science.gov (United States)

    Kemper, Edward

    Quad-Rotor unmanned areal vehicles (UAVs) have been a popular area of research and development in the last decade, especially with the advent of affordable microcontrollers like the MSP 430 and the Raspberry Pi. Path-Energy Optimization is an area that is well developed for linear systems. In this thesis, this idea of path-energy optimization is extended to the nonlinear model of the Quad-rotor UAV. The classical optimization technique is adapted to the nonlinear model that is derived for the problem at hand, coming up with a set of partial differential equations and boundary value conditions to solve these equations. Then, different techniques to implement energy optimization algorithms are tested using simulations in Python. First, a purely nonlinear approach is used. This method is shown to be computationally intensive, with no practical solution available in a reasonable amount of time. Second, heuristic techniques to minimize the energy of the flight path are tested, using Ziegler-Nichols' proportional integral derivative (PID) controller tuning technique. Finally, a brute force look-up table based PID controller is used. Simulation results of the heuristic method show that both reliable control of the system and path-energy optimization are achieved in a reasonable amount of time.

  12. Taking a Technological Path to Poetry Prewriting.

    Science.gov (United States)

    Roberts, Sherron Killingsworth

    2002-01-01

    Offers a strong rationale for the idea that the journey of writing good poetry begins on a path that infuses technology into the first stage of the writing process. Presents several ideas of ways to incorporate technology into the prewriting poetry experience. Concludes that by making technology an ingredient, the true potential for synergy…

  13. Unidirectional Motion of Vehicle on Sinusoidal Path

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 4. Unidirectional Motion of Vehicle on Sinusoidal Path: Can it Cause Illusory Forward and Backward Motion? Anuj Bhatnagar. Classroom Volume 17 Issue 4 April 2012 pp 387-392 ...

  14. Feynman path integral formulation of quantum mechanics

    International Nuclear Information System (INIS)

    Mizrahi, M.M.

    1975-01-01

    The subject of this investigation is Feynman's path integral quantization scheme, which is a powerful global formalism with great intuitive appeal. It stems from the simple idea that a probability amplitude for a system to make a transition between two states is the ''sum'' of the amplitudes for all the possible ways the transition can take place

  15. Path integral quantization of parametrized field theory

    International Nuclear Information System (INIS)

    Varadarajan, Madhavan

    2004-01-01

    Free scalar field theory on a flat spacetime can be cast into a generally covariant form known as parametrized field theory in which the action is a functional of the scalar field as well as the embedding variables which describe arbitrary, in general curved, foliations of the flat spacetime. We construct the path integral quantization of parametrized field theory in order to analyze issues at the interface of quantum field theory and general covariance in a path integral context. We show that the measure in the Lorentzian path integral is nontrivial and is the analog of the Fradkin-Vilkovisky measure for quantum gravity. We construct Euclidean functional integrals in the generally covariant setting of parametrized field theory using key ideas of Schleich and show that our constructions imply the existence of nonstandard 'Wick rotations' of the standard free scalar field two-point function. We develop a framework to study the problem of time through computations of scalar field two-point functions. We illustrate our ideas through explicit computation for a time independent (1+1)-dimensional foliation. Although the problem of time seems to be absent in this simple example, the general case is still open. We discuss our results in the contexts of the path integral formulation of quantum gravity and the canonical quantization of parametrized field theory

  16. Feature based omnidirectional sparse visual path following

    OpenAIRE

    Goedemé, Toon; Tuytelaars, Tinne; Van Gool, Luc; Vanacker, Gerolf; Nuttin, Marnix

    2005-01-01

    Goedemé T., Tuytelaars T., Van Gool L., Vanacker G., Nuttin M., ''Feature based omnidirectional sparse visual path following'', Proceedings IEEE/RSJ international conference on intelligent robots and systems - IROS2005, pp. 1003-1008, August 2-6, 2005, Edmonton, Alberta, Canada.

  17. Certified higher-order recursive path ordering

    NARCIS (Netherlands)

    Koprowski, A.; Pfenning, F.

    2006-01-01

    The paper reports on a formalization of a proof of wellfoundedness of the higher-order recursive path ordering (HORPO) in the proof checker Coq. The development is axiom-free and fully constructive. Three substantive parts that could be used also in other developments are the formalizations of the

  18. Path-breaking books in regional science

    NARCIS (Netherlands)

    Waldorf, BS

    This article presents a collection of regional science books that long-standing members of the Regional Science Association International (RSAI) identified as path-breaking books. The most frequently nominated books include the "classics" by Isard, the seminal books in urban economics by Alonso,

  19. Covariant path integrals on hyperbolic surfaces

    Science.gov (United States)

    Schaefer, Joe

    1997-11-01

    DeWitt's covariant formulation of path integration [B. De Witt, "Dynamical theory in curved spaces. I. A review of the classical and quantum action principles," Rev. Mod. Phys. 29, 377-397 (1957)] has two practical advantages over the traditional methods of "lattice approximations;" there is no ordering problem, and classical symmetries are manifestly preserved at the quantum level. Applying the spectral theorem for unbounded self-adjoint operators, we provide a rigorous proof of the convergence of certain path integrals on Riemann surfaces of constant curvature -1. The Pauli-DeWitt curvature correction term arises, as in DeWitt's work. Introducing a Fuchsian group Γ of the first kind, and a continuous, bounded, Γ-automorphic potential V, we obtain a Feynman-Kac formula for the automorphic Schrödinger equation on the Riemann surface ΓH. We analyze the Wick rotation and prove the strong convergence of the so-called Feynman maps [K. D. Elworthy, Path Integration on Manifolds, Mathematical Aspects of Superspace, edited by Seifert, Clarke, and Rosenblum (Reidel, Boston, 1983), pp. 47-90] on a dense set of states. Finally, we give a new proof of some results in C. Grosche and F. Steiner, "The path integral on the Poincare upper half plane and for Liouville quantum mechanics," Phys. Lett. A 123, 319-328 (1987).

  20. Directed paths in a layered environment

    International Nuclear Information System (INIS)

    Alvarez, J; Janse van Rensburg, E J

    2008-01-01

    A polymer in a layered environment is modeled as a directed path in a layered square lattice composed of alternating A-layers of width w a and B-layers of width w b . In this paper we consider general cases of this model, where edges in the path interact with the layers, and vertices in the path interact with interfaces between adjacent layers. The phase diagram exhibits different regimes. In particular, we found that the path may be localized to one layer, be adsorbed on an interface between two layers or be delocalized across layers. We examine special aspects of the model in detail: the asymptotic regimes of the models are examined, and entropic forces on the interfaces are determined. We focus on several different cases, including models with layers of equal or similar width. More general models of layers with different but finite widths, or with one layer of infinite width, are also examined in detail. Several of these models exhibit phase behavior which relate to well-studied polymer phase behavior such as adsorption at an impenetrable wall, pinning at an interface between two immiscible solvents, steric stabilization of colloidal particles and sensitized flocculation of colloidal particles by polymers

  1. Random paths with curvature dependent action

    International Nuclear Information System (INIS)

    Ambjoern, J.; Durhuus, B.

    1986-11-01

    We study discretized random paths with a curvature dependent action. The scaling limits of the corresponding statistical mechanical models can be constructed explicitly and are either usual Brownian motion or a theory where the correlations of tangents are nonzero and described by diffusion on the unit sphere. In the latter case the two point function has an anomalous dimension η = 1. (orig.)

  2. Comparison of classical reaction paths and tunneling paths studied with the semiclassical instanton theory.

    Science.gov (United States)

    Meisner, Jan; Markmeyer, Max N; Bohner, Matthias U; Kästner, Johannes

    2017-08-30

    Atom tunneling in the hydrogen atom transfer reaction of the 2,4,6-tri-tert-butylphenyl radical to 3,5-di-tert-butylneophyl, which has a short but strongly curved reaction path, was investigated using instanton theory. We found the tunneling path to deviate qualitatively from the classical intrinsic reaction coordinate, the steepest-descent path in mass-weighted Cartesian coordinates. To perform that comparison, we implemented a new variant of the predictor-corrector algorithm for the calculation of the intrinsic reaction coordinate. We used the reaction force analysis method as a means to decompose the reaction barrier into structural and electronic components. Due to the narrow energy barrier, atom tunneling is important in the abovementioned reaction, even above room temperature. Our calculated rate constants between 350 K and 100 K agree well with experimental values. We found a H/D kinetic isotope effect of almost 10 6 at 100 K. Tunneling dominates the protium transfer below 400 K and the deuterium transfer below 300 K. We compared the lengths of the tunneling path and the classical path for the hydrogen atom transfer in the reaction HCl + Cl and quantified the corner cutting in this reaction. At low temperature, the tunneling path is about 40% shorter than the classical path.

  3. Prognostic value of proliferation in pleomorphic soft tissue sarcomas

    DEFF Research Database (Denmark)

    Seinen, Jojanneke M; Jönsson, Mats; Bendahl, Pär-Ola O

    2012-01-01

    = 1.6-12.1), Top2a (hazard ratio = 2.2, CI = 1.2-3.5) and high S-phase fraction (hazard ratio = 1.8, CI = 1.2-3.7) significantly correlated with risk for metastasis. When combined with currently used prognostic factors, Ki-67, S-phase fraction and Top2a fraction contributed to refined identification...... of prognostic risk groups. Proliferation, as assessed by expression of Ki-67 and Top2a and evaluation of S-phase fraction and applied to statistical decision-tree models, provides prognostic information in soft tissue sarcomas of the extremity and trunk wall. Though proliferation contributes independently...... to currently applied prognosticators, its role is particularly strong when few other factors are available, which suggests a role in preoperative decision-making related to identification of high-risk individuals who would benefit from neoadjuvant therapy....

  4. Commercial Satellite Imagery Analysis for Countering Nuclear Proliferation

    Science.gov (United States)

    Albright, David; Burkhard, Sarah; Lach, Allison

    2018-05-01

    High-resolution commercial satellite imagery from a growing number of private satellite companies allows nongovernmental analysts to better understand secret or opaque nuclear programs of countries in unstable or tense regions, called proliferant states. They include North Korea, Iran, India, Pakistan, and Israel. By using imagery to make these countries’ aims and capabilities more transparent, nongovernmental groups like the Institute for Science and International Security have affected the policies of governments and the course of public debate. Satellite imagery work has also strengthened the efforts of the International Atomic Energy Agency, thereby helping this key international agency build its case to mount inspections of suspect sites and activities. This work has improved assessments of the nuclear capabilities of proliferant states. Several case studies provide insight into the use of commercial satellite imagery as a key tool to educate policy makers and affect policy.

  5. The Rarotonga treaty: regional approach to non-proliferation in the South Pacific

    International Nuclear Information System (INIS)

    Papadimitropulos, P.

    1988-01-01

    The regional approach to the problem of non-proliferation in the South-Pacific-the Rarotonga treaty - is discussed. The regional approach to the problem of non-proliferation is aimed in a wide sense at the assistance to detante in a certain region and the propagation of measures strengthening confidence there. On December 11, 1975 at the initiative of New Zealand and Fiji the UN General Assembly adopted a resolution on the nuclear-free zone in the South-Pacific. In compliance with the Rarotonga treaty a large nuclear-free zone is created. The participants of the Rarotonga Treaty assess the values of the Non-Proliferation Treaty

  6. A Path-Independent Forming Limit Criterion for Stamping Simulations

    International Nuclear Information System (INIS)

    Zhu Xinhai; Chappuis, Laurent; Xia, Z. Cedric

    2005-01-01

    Forming Limit Diagram (FLD) has been proved to be a powerful tool for assessing necking failures in sheet metal forming analysis for majority of stamping operations over the last three decades. However, experimental evidence and theoretical analysis suggest that its applications are limited to linear or almost linear strain paths during its deformation history. Abrupt changes or even gradual deviations from linear strain-paths will shift forming limit curves from their original values, a situation that occurs in vast majority of sequential stamping operations such as where the drawing process is followed by flanging and re-strike processes. Various forming limit models have been put forward recently to provide remedies for the problem, noticeably stress-based and strain gradient-based forming limit criteria. This study presents an alternative path-independent forming limit criterion. Instead of traditional Forming Limit Diagrams (FLD) which are constructed in terms of major - minor principal strains throughout deformation history, the new criterion defines a critical effective strain ε-bar* as the limit strain for necking, and it is shown that ε-bar* can be expressed as a function of current strain rate state and material work hardening properties, without the need of explicitly considering strain-path effects. It is given by ε-bar* = f(β, k, n) where β = (dε 2 /dε 1 ) at current deformation state, and k and n are material strain hardening parameters if a power law is assumed. The analysis is built upon previous work by Storen and Rice [1975] and Zhu et al [2002] with the incorporation of anisotropic yield models such as Hill'48 for quadratic orthotropic yield and Hill'79 for non-quadratic orthotropic yield. Effects of anisotropic parameters such as R-values and exponent n-values on necking are investigated in detail for a variety of strain paths. Results predicted according to current analysis are compared against experimental data gathered from literature

  7. Canada's nuclear non-proliferation policy

    International Nuclear Information System (INIS)

    1982-05-01

    Canada's non-proliferation safeguards policy has two objectives: 1) to promote a more effective and comprehensive international non-proliferation regime; and 2) to ensure that Canadian nuclear exports will not be used for any nuclear explosive purpose. By emphasizing the key role of the Non-Proliferation Treaty, promoting reliance upon and improvements in the IAEA safeguards system, treating nuclear weapon and non-weapon states alike, and working for new approaches covering reprocessing, Canada promotes attainment of the first objective. The second is served through the network of bilateral nuclear agreements that Canada has put into place with its partners. The Canadian objective in post-INFCE forums is to persuade the international community to devise a more effective and comprehensive non-proliferation regime into which Canada and other suppliers may subsume their national requirements

  8. Handbook for nuclear non-proliferation

    International Nuclear Information System (INIS)

    Lee, Byung Wook; Oh, Keun Bae; Lee, Kwang Seok; Lee, Dong Jin; Ko, Han Seok.

    1997-05-01

    This book analyzed international non-proliferation regime preventing from spread of nuclear weapon. This book took review from the historical background of non-proliferation regime to the recent changes and status. The regime, here, is divided into multilateral and bilateral regime. First of all, this book reports four multilateral treaties concluded for non-proliferation such as NPT, NWFZ, CTBT and others. Secondly, international organization and regimes concerned with non-proliferation are analyzed with emphasis of UN, IAEA, ZC and NSG, Regional Safeguards System and international conference. Finally, this book report the current circumstances of nuclear cooperation agreement related with Korea which is an important means for bilateral regime. (author). 13 tabs., 2 figs

  9. Nuclear experts and nuclear weapons proliferation

    International Nuclear Information System (INIS)

    Mueller, H.

    1979-01-01

    In Germany the issue of nuclear weapons proliferation has attracted scant attention. Most potential nuclear weapon states are important trade partners of the FRG and, since further proliferation of nuclear weapons could worsen conflicts involving these, it should be in the FRG's interest to limit proliferation. The security of the FRG is also dependent on the common interest of the great powers to avoid nuclear war. The contradictory positions of Usa and the USSR on nuclear weapons policy regarding themselves and non-nuclear weapon states encourages less developed countries to see nuclear weaponry as useful. The NPT and IAEA safeguards have only limited inhibiting effect. The nuclear export policy of the FRG has been dominated by short term economic advantage, neglecting the negative long term effects of decreased political stability. The FRG should formulate a policy based on self-restraint, positive stimuli and extension of controls, using its economic strength to deter proliferation. (JIW)

  10. Handbook for nuclear non-proliferation

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Wook; Oh, Keun Bae; Lee, Kwang Seok; Lee, Dong Jin; Ko, Han Seok

    1997-05-01

    This book analyzed international non-proliferation regime preventing from spread of nuclear weapon. This book took review from the historical background of non-proliferation regime to the recent changes and status. The regime, here, is divided into multilateral and bilateral regime. First of all, this book reports four multilateral treaties concluded for non-proliferation such as NPT, NWFZ, CTBT and others. Secondly, international organization and regimes concerned with non-proliferation are analyzed with emphasis of UN, IAEA, ZC and NSG, Regional Safeguards System and international conference. Finally, this book report the current circumstances of nuclear cooperation agreement related with Korea which is an important means for bilateral regime. (author). 13 tabs., 2 figs.

  11. The future of non-proliferation

    International Nuclear Information System (INIS)

    Gere, F.

    2000-01-01

    This paper comprises two parts. The first part makes a status of the non-proliferation policy: problems of ratification of Start 2 and CTBT treaties, nuclear tests in India and Pakistan in May 1998 etc. The second part makes a prospective reflexion on the evolution of the position of nuclearized countries at the 2015-2030 vista: role of Asia, nuclear perception, evolution of the US perception of non-proliferation, military strategy and European unification. (J.S.)

  12. Nuclear power and the proliferation issue

    International Nuclear Information System (INIS)

    Marshall, W.

    1978-02-01

    The purpose of the lecture is to discuss nuclear proliferation, analyse which problems are real and which are a misapprehension, and to suggest a way forward which retains the benefits of nuclear power while providing a more certain protection against undesirable proliferation. After an introductory section the lecture continues under the following headings: plutonium production and accessibility; the use of plutonium; fast reactor fuel; the interim period; conclusions. (U.K.)

  13. Panel on nuclear export and proliferation

    International Nuclear Information System (INIS)

    Kimel, W.R.

    1977-01-01

    Summaries of six panelists' remarks make the following points: one cannot suppress nuclear weapons by suppressing nuclear power; a proliferated world would be extremely dangerous; US supports IAEA safeguards; plutonium shouldn't be recycled in power reactors; and the problem of nonproliferation is a social and institutional problem, not a technological one. Viewographs showing the semantics of proliferation, ways to get nuclear weapons materials, etc. are included

  14. Russia and proliferation in Northeast Asia

    International Nuclear Information System (INIS)

    Ignatov, A.I.

    1995-01-01

    For Russia, security, including non-proliferation, in Northeast Asia means in particular the maintenance of stability. Progress in arms control and non-proliferation may enhance regional stability. A common regional approach is proposed. Russia recognizes the US alliances with Japan and republic of Korea and is searching for a new cooperation framework in the region, namely further development of relations with China and reasonable rapprochement with Japan

  15. Managing Proliferation Issues with Iran

    International Nuclear Information System (INIS)

    Nelson, C. Richard; Saltiel, David H.

    2002-01-01

    particular, will continue to play a vital role in determining the extent to which Iran is able to pursue WMD options. Without a fundamental change in the regional security environment, however, there is little reason to expect changes in Iranian WMD and missile policies, and the United States, acting alone and short of war, cannot prevent Iran from ultimately developing WMD and delivery systems. Furthermore, U.S. policies that take a tougher line with Russia, China and North Korea are not likely to lead to more restraint among these potential sources of WMD and missile technology. In the absence of engagement with Iran, unilateral U.S. economic sanctions will remain the principal, if flawed, U.S. policy tool for seeking to prevent Iran from acquiring WMD. The rationale is that by discouraging trade and investment, particularly in Iran's energy sector, the government of Iran will have less revenue to pursue proliferation. Without broad international support for economic isolation, however, such an effort may hinder Iran's WMD programs, though it cannot block them. Finally, options are needed to deal with major failures in nonproliferation efforts. These options include measures to deter Iranian use of WMD, to defend against their use if deterrence fails, and to destroy Iranian WMD capabilities should the need arise

  16. Strengthening the nuclear non-proliferation regime

    International Nuclear Information System (INIS)

    Carlson, J.

    2003-01-01

    Although the nuclear non-proliferation regime has enjoyed considerable success, today the regime has never been under greater threat. Three states have challenged the objectives of the NPT, and there is a technology challenge - the spread of centrifuge enrichment technology and know-how. A major issue confronting the international community is, how to deal with a determined proliferator? Despite this gloomy scenario, however, the non-proliferation regime has considerable strengths - many of which can be developed further. The regime comprises complex interacting and mutually reinforcing elements. At its centre is the NPT - with IAEA safeguards as the Treaty's verification mechanism. Important complementary elements include: restraint in the supply and the acquisition of sensitive technologies; multilateral regimes such as the CTBT and proposed FMCT; various regional and bilateral regimes; the range of security and arms control arrangements outside the nuclear area (including other WMD regimes); and the development of proliferation-resistant technologies. Especially important are political incentives and sanctions in support of non-proliferation objectives. This paper outlines some of the key issues facing the non-proliferation regime

  17. Path Integrals and Anomalies in Curved Space

    International Nuclear Information System (INIS)

    Louko, Jorma

    2007-01-01

    Bastianelli and van Nieuwenhuizen's monograph 'Path Integrals and Anomalies in Curved Space' collects in one volume the results of the authors' 15-year research programme on anomalies that arise in Feynman diagrams of quantum field theories on curved manifolds. The programme was spurred by the path-integral techniques introduced in Alvarez-Gaume and Witten's renowned 1983 paper on gravitational anomalies which, together with the anomaly cancellation paper by Green and Schwarz, led to the string theory explosion of the 1980s. The authors have produced a tour de force, giving a comprehensive and pedagogical exposition of material that is central to current research. The first part of the book develops from scratch a formalism for defining and evaluating quantum mechanical path integrals in nonlinear sigma models, using time slicing regularization, mode regularization and dimensional regularization. The second part applies this formalism to quantum fields of spin 0, 1/2, 1 and 3/2 and to self-dual antisymmetric tensor fields. The book concludes with a discussion of gravitational anomalies in 10-dimensional supergravities, for both classical and exceptional gauge groups. The target audience is researchers and graduate students in curved spacetime quantum field theory and string theory, and the aims, style and pedagogical level have been chosen with this audience in mind. Path integrals are treated as calculational tools, and the notation and terminology are throughout tailored to calculational convenience, rather than to mathematical rigour. The style is closer to that of an exceedingly thorough and self-contained review article than to that of a textbook. As the authors mention, the first part of the book can be used as an introduction to path integrals in quantum mechanics, although in a classroom setting perhaps more likely as supplementary reading than a primary class text. Readers outside the core audience, including this reviewer, will gain from the book a

  18. A study on the proliferation resistance evaluation methodology for nuclear energy system

    International Nuclear Information System (INIS)

    Kim, Min Su

    2007-02-01

    The framework of proliferation resistance evaluation methodology, based on attribute analysis and scenario analysis, for nuclear energy system is suggested in order to allow for the comprehensive assessment of proliferation resistance by addressing the intrinsic and extrinsic features of nuclear energy system. Proliferation resistance is viewed within the context of the success tree model of proliferator's diversion attempt and expressed by the value of top event probability of the success tree model. This study focused on the method that the value of top event is estimated. The methodology uses two different methods to quantify the likelihood of basic events constituting the top event. The likelihood of basic event success affected by intrinsic feature of nuclear energy system was assessed by using multi-attribute utility theory and likelihood of basic event related to the diversion detection measures was assessed by direct expert elicitation. The value of top event was calculated based on the intersection of probabilities of basic event success. Feasibility of the methodology was explored by applying it to selected reference nuclear energy systems. System-Integrated Modular Advanced Reactor (SMART) system and Light Water Reactor (LWR) were chosen as reference systems and the value proliferation resistance of SMART and LWR were evaluated. Characteristics of inherent features and hypothesized safeguards measures of both systems were identified and used as input data to evaluate proliferation resistance. The results and conclusions are applicable only within the context of subjectivity of this methodology

  19. Nuclear arbitration: Interpreting non-proliferation agreements

    International Nuclear Information System (INIS)

    Tzeng, Peter

    2015-01-01

    At the core of the nuclear non-proliferation regime lie international agreements. These agreements include, inter alia, the Nuclear Non-proliferation Treaty, nuclear co-operation agreements and nuclear export control agreements.1 States, however, do not always comply with their obligations under these agreements. In response, commentators have proposed various enforcement mechanisms to promote compliance. The inconvenient truth, however, is that states are generally unwilling to consent to enforcement mechanisms concerning issues as critical to national security as nuclear non-proliferation.3 This article suggests an alternative solution to the non-compliance problem: interpretation mechanisms. Although an interpretation mechanism does not have the teeth of an enforcement mechanism, it can induce compliance by providing an authoritative interpretation of a legal obligation. Interpretation mechanisms would help solve the non-compliance problem because, as this article shows, in many cases of alleged non-compliance with a non-proliferation agreement, the fundamental problem has been the lack of an authoritative interpretation of the agreement, not the lack of an enforcement mechanism. Specifically, this article proposes arbitration as the proper interpretation mechanism for non-proliferation agreements. It advocates the establishment of a 'Nuclear Arbitration Centre' as an independent branch of the International Atomic Energy Agency (IAEA), and recommends the gradual introduction of arbitration clauses into the texts of non-proliferation agreements. Section I begins with a discussion of international agreements in general and the importance of interpretation and enforcement mechanisms. Section II then discusses nuclear non-proliferation agreements and their lack of interpretation and enforcement mechanisms. Section III examines seven case studies of alleged non-compliance with non-proliferation agreements in order to show that the main problem in many cases

  20. Computing LS factor by runoff paths on TIN

    Science.gov (United States)

    Kavka, Petr; Krasa, Josef; Bek, Stanislav

    2013-04-01

    a part of the Atlas DMT software package. Starting points for the flow direction generation remain in regular grid (allowing easy contributing area assessment) while realistic direction paths are generated directly at TIN. It turns out that this procedure allows predicting actual runoff paths while ensuring the continuity of the potential runoff by sophisticated filling of sinks and flats. The algorithm is being implemented in a new USLE based erosion model ATLAS EROSION aiming to enhance designing of technical (morphological) soil erosion measures using detailed DEMs. The research has been supported by the research project No. TA02020647 " Atlas EROZE - a modern tool for soil erosion assessment".