WorldWideScience

Sample records for program concerns specific

  1. Healthy me: A gender-specific program to address body image concerns and risk factors among preadolescents.

    Science.gov (United States)

    McCabe, Marita P; Connaughton, Catherine; Tatangelo, Gemma; Mellor, David; Busija, Lucy

    2017-03-01

    This study evaluated a gender-specific, school-based program to promote positive body image and address risk factors for body dissatisfaction. In total, 652 children aged 8-10 years participated (335 intervention, 317 wait-list control). Children participated in four 60min sessions and a recap session at three months post-intervention. The broad content areas were body image, peer relationships, media awareness, healthy diet, and exercise. The activities and examples for each session were gender specific. The recap session was an overview of the four sessions. Assessment measures were completed at pre-intervention, post-intervention, and after the recap. Boys and girls in the intervention demonstrated higher muscle esteem and vegetable intake at post-intervention, compared to children in the control condition. Boys and girls demonstrated higher body esteem, muscle esteem and fruit and vegetable intake at the recap. Boys in the intervention demonstrated less investment in masculine gender norms at post-intervention and at recap. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. International Students' Concerns: Directions for Supportive Programming.

    Science.gov (United States)

    Bontrager, Terry; And Others

    1990-01-01

    Questionnaire responses from over 75 international students from 40 nations revealed that newly arrived and continuing students had similar concerns. The concern that students ranked highest was finding or keeping a job. Homesickness and general worries ranked second, followed by time for recreational and artistic activities, a need for more…

  3. Military Space Programs: Issues Concerning DOD's SBIRS and STSS Programs

    National Research Council Canada - National Science Library

    Smith, Marcia S

    2006-01-01

    The Department of Defense's (DOD's) programs to develop new satellites to alert U.S. military commanders to foreign missile launches, and to support missile defense objectives, are controversial because of cost growth and schedule slippage...

  4. Military Space Programs: Issues Concerning DOD's SBIRS and STSS Programs

    National Research Council Canada - National Science Library

    Smith, Marcia S

    2005-01-01

    The Department of Defense's (DOD's) programs to develop new satellites to alert U.S. military commanders to foreign missile launches, and to support missile defense objectives, are controversial because of cost growth and schedule slippage...

  5. Military Space Programs: Issues Concerning DOD's SBIRS and STSS Programs

    National Research Council Canada - National Science Library

    Smith, Marcia S

    2003-01-01

    The Department of Defense's (DOD's) programs to develop new satellites to alert U.S. military commanders to foreign missile launches, and to support missile defense objectives, are controversial because of cost growth and schedule slippage...

  6. Dynamics of the public concern and risk communication program implementation.

    Science.gov (United States)

    Zaryabova, Victoria; Israel, Michel

    2015-09-01

    The public concern about electromagnetic field (EMF) exposure varies due to different reasons. A part of them are connected with the better and higher quality of information that people receive from science, media, Internet, social networks, industry, but others are based on good communication programs performed by the responsible institutions, administration and persons. Especially, in Bulgaria, public concern follows interesting changes, some of them in correlation with the European processes of concern, but others following the economic and political processes in the country. Here, we analyze the dynamics of the public concern over the last 10 years. Our explanation of the decrease of the people's complaints against EMF exposure from base stations for mobile communication is as a result of our risk communication program that is in implementation for >10 years.

  7. General versus program-specific welfare chauvinism

    DEFF Research Database (Denmark)

    Larsen, Christian Albrekt

    2017-01-01

    care, whereas permanent exclusion is favoured for other programs, e.g. child allowances given to children in country of origin. These findings support the thesis of program-specific welfare chauvinism and point to a political space for pragmatic adjustments of current EU rules. The article also finds......The article investigates how welfare chauvinism differs across various social benefits and services. The case is Danes’ attitudes towards granting social rights to Eastern European workers. For some programs a clear majority favours giving social rights immediately on arrival, e.g. rights to health...... similarity across programs. The Danish welfare chauvinist attitudes are in general fuelled by lack of shared identity with migrants and sociotropic concerns about the economic burden of migration. The article finds little evidence of narrow self-interest effects; with a notable exception of disability...

  8. The informal investment context: specific issues concerned with business angels

    Directory of Open Access Journals (Sweden)

    Jon Hoyos Iruarrizaga

    2013-01-01

    Full Text Available Informal investors play a key role to meet the financing needs of business projects in early stages. However, this is a group in which there are different kinds and ways of dealing with investment. One of these profiles is associated with the figure known as business angel, whose main distinguishing feature is its ability to add smart capital in the form of knowledge, experience and contacts. The aim of this paper is to determine to what extent the specific profile of business angels differ from the rest of informal investors. With a sample of over 800 informal investors in Spain, the empirical results of this study show that the higher income, skills and entrepreneurial training and the less family ties to the entrepreneur, the greater the probability of belonging to business angel investment group.

  9. 76 FR 62312 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Science.gov (United States)

    2011-10-07

    ... Animal and Plant Health Inspection Service 7 CFR Part 331 9 CFR Part 121 Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public Meeting AGENCIES: Animal and... biological agents and toxins, that a meeting will be held to provide specific regulatory guidance related to...

  10. 77 FR 48527 - National Customs Automation Program (NCAP) Test Concerning Automated Commercial Environment (ACE...

    Science.gov (United States)

    2012-08-14

    ... SECURITY U.S. Customs and Border Protection National Customs Automation Program (NCAP) Test Concerning...: General notice. SUMMARY: This notice announces modifications to the National Customs Automation Program...) National Customs Automation Program (NCAP) test concerning Automated Commercial Environment (ACE...

  11. 78 FR 75931 - National Customs Automation Program (NCAP) Test Concerning the Submission of Certain Data...

    Science.gov (United States)

    2013-12-13

    ... SECURITY U.S. Customs and Border Protection National Customs Automation Program (NCAP) Test Concerning the... Customs Automation Program (NCAP) test concerning transmission of electronic filings of certain... Customs Automation Program The National Customs Automation Program (NCAP) was established in Subtitle B of...

  12. Adolescent depressive symptoms and smoking behavior: The gender-specific role of weight concern and dieting

    NARCIS (Netherlands)

    Larsen, J.K.; Otten, R.; Engels, R.C.M.E.

    2009-01-01

    Objective - Increased weight concern and dieting are associated with both depression and smoking among adolescents, particularly girls. This cross-sectional study examined the gender-specific role of weight concerns and dieting on the adolescent depression–smoking association. Methods - Participants

  13. Case Based Specifications – reusing specifications, programs and proofs

    OpenAIRE

    Monahan, Rosemary; O'Donoghue, Diarmuid P.

    2012-01-01

    Many software verification tools use the design-by-contract approach to annotate programs with assertions so that tools, such as compilers, can generate the proof obligations required to verify that a program satisfies its specification. Theorem provers and SMT solvers are then used to, often automatically, discharge the proof obligations that have been generated.

  14. 32 CFR 724.224 - Court-martial specifications, presumption concerning.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Court-martial specifications, presumption...-martial specifications, presumption concerning. (a) Relevant and material facts stated in a court-martial... dismissal adjudged by a court-martial case tried under the Uniform Code of Military Justice, the action may...

  15. An introduction to programming with specifications

    CERN Document Server

    1991-01-01

    A feature of modern advanced computing is the functional approach to programming. In this book, the authors present an introduction to the mathematics which underline functional programming, emphasizing the understanding of definition and specification--a prerequisite of good programming and problem solving with a computer. The book is self-contained, requiring a low level of mathematical sophistication and may be used as an introduction to the mathematics of programming.Provides an introduction to the functional approach to programming**Emphasizes the problem to be solved, not the pro

  16. Observations concerning Research Literature on Neuro-Linguistic Programming.

    Science.gov (United States)

    Einspruch, Eric L.; Forman, Bruce D.

    1985-01-01

    Identifies six categories of design and methodological errors contained in the 39 empirical studies of neurolinguistic programming (NLP) documented through April 1984. Representative reports reflecting each category are discussed. Suggestions are offered for improving the quality of research on NLP. (Author/MCF)

  17. 76 FR 69755 - National Customs Automation Program Test Concerning Automated Commercial Environment (ACE...

    Science.gov (United States)

    2011-11-09

    ... SECURITY U.S. Customs and Border Protection National Customs Automation Program Test Concerning Automated... Protection's (CBP's) plan to conduct a National Customs Automation Program (NCAP) test concerning Automated..., at [email protected] . SUPPLEMENTARY INFORMATION: Background The National Customs Automation...

  18. Automatic program generation from specifications using PROLOG

    Science.gov (United States)

    Pelin, Alex; Morrow, Paul

    1988-01-01

    An automatic program generator which creates PROLOG programs from input/output specifications is described. The generator takes as input descriptions of the input and output data types, a set of transformations and the input/output relation. Abstract data types are used as models for data. They are defined as sets of terms satisfying a system of equations. The tests, the transformations and the input/output relation are also specified by equations.

  19. 77 FR 56845 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Science.gov (United States)

    2012-09-14

    ... HUMAN SERVICES Centers for Disease Control and Prevention Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public Webcast AGENCY: Centers for Disease Control and... (HHS) announces the notice of a public webcast concerning compliance with the Federal Select Agent...

  20. Making the "Child Safe" Environment "Adult Safe": Occupational Health and Safety Concerns for Child Care Programs.

    Science.gov (United States)

    Whitebook, Marcy; Ginsburg, Gerri

    Results of a nonrandom nationwide survey of 89 child care workers in 20 states concerning work-related health and safety conditions confirm that similar hazardous conditions exist in child care programs throughout the nation. Results also confirm that concern and anger about such conditions and their potential consequences are widespread among…

  1. 77 FR 20835 - National Customs Automation Program (NCAP) Test Concerning Automated Commercial Environment (ACE...

    Science.gov (United States)

    2012-04-06

    ... SECURITY U.S. Customs and Border Protection National Customs Automation Program (NCAP) Test Concerning.... Customs and Border Protection's (CBP's) plan to conduct a National Customs Automation Program (NCAP) test... at [email protected] . SUPPLEMENTARY INFORMATION: Background The National Customs Automation...

  2. The Effects of Peer Coaching on the Evaluation Knowledge, Skills, and Concerns of Gifted Program Administrators

    Science.gov (United States)

    Cotabish, Alicia; Robinson, Ann

    2012-01-01

    To increase knowledge and skills in program evaluation, a peer-coaching intervention provided one-on-one professional development to gifted program administrators. This randomized field study examined the effects of peer coaching on evaluation knowledge and skills and on administrators' concerns about implementing more rigorous program…

  3. Surviving colorectal cancer: long-term, persistent ostomy-specific concerns and adaptations.

    Science.gov (United States)

    Sun, Virginia; Grant, Marcia; McMullen, Carmit K; Altschuler, Andrea; Mohler, M Jane; Hornbrook, Mark C; Herrinton, Lisa J; Baldwin, Carol M; Krouse, Robert S

    2013-01-01

    The purpose of this article was to describe persistent ostomy-specific concerns and adaptations in long-term (>5 years) colorectal cancer survivors with ostomies. Thirty-three colorectal cancer survivors who participated in 8 gender- and health-related quality of life stratified focus groups and 130 colorectal cancer survivors who provided written comments to 2 open-ended questions on ostomy location and pouch problems participated in the study. Data were collected on health maintenance organization members in Oregon, southwestern Washington, and northern California. Qualitative data were analyzed for the 8 focus groups and written comments from 2 open-ended survey questions. Discussions from the focu s groups were recorded, transcribed, and analyzed using content analysis. Written content from the open-ended questions was derived from a mailed questionnaire on health-related quality of life in survivors with ostomies and analyzed using content analysis. Discussions related to persistent ostomy-related issues more than 5 years after formation were common. Persistent ostomy-related issues were focused on clothing restrictions and adaptations, dietary concerns, issues related to ostomy equipment and self-care, and the constant need to find solutions to adjust and readjust to living with an ostomy. Ostomy-specific concerns persist 5 years and more for long-term colorectal cancer survivors after initial ostomy formation. Adaptations tend to be individualized and based on trial and error. Findings underscore the need to develop long-term support mechanisms that survivors can access to promote better coping and adjustment to living with an ostomy.

  4. Surviving Colorectal Cancer: Long-Term, Persistent Ostomy-Specific Concerns and Adaptations

    Science.gov (United States)

    Sun, Virginia; Grant, Marcia; McMullen, Carmit K.; Altschuler, Andrea; Mohler, M. Jane; Hornbrook, Mark C.; Herrinton, Lisa J.; Baldwin, Carol M.; Krouse, Robert S.

    2012-01-01

    Purpose The purpose of this paper is to describe persistent ostomy-specific concerns and adaptations in long-term (> 5 years) colorectal cancer survivors with ostomies. Subjects and Settings Thirty three colorectal cancer survivors who participated in eight gender- and health related Quality of life (HRQOL) stratified focus groups and 130 colorectal cancer survivors who provided written comments to two open-ended questions on ostomy location and pouch problems participated in the study. Data were collected on health maintenance organization members in Oregon, southwestern Washington and northern California. Methods Qualitative data were analyzed for the 8 focus groups and written comments from 2 open-ended survey questions. Discussions from the focus groups were recorded, transcribed and analyzed using content analysis. Written content from the open-ended questions was derived from a mailed questionnaire on health related quality of life in survivors with ostomies and analyzed using content analysis. Results Discussions related to persistent ostomy-related issues more than 5 years after formation were common. Persistent ostomy-related issues were focused on clothing restrictions and adaptations, dietary concerns, issues related to ostomy equipment and self-care, and the constant need to find solutions to adjust and re-adjust to living with an ostomy. Conclusions Ostomy-specific concerns persist 5 years and more for long-term colorectal cancer survivors after initial ostomy formation. Adaptations tend to be individualized and based on trial and error. Findings underscore the need to develop long-term support mechanisms that survivors can access to promote better coping and adjustment to living with an ostomy. PMID:23222968

  5. The programming language HAL: A specification

    Science.gov (United States)

    1971-01-01

    HAL accomplishes three significant objectives: (1) increased readability, through the use of a natural two-dimensional mathematical format; (2) increased reliability, by providing for selective recognition of common data and subroutines, and by incorporating specific data-protect features; (3) real-time control facility, by including a comprehensive set of real-time control commands and signal conditions. Although HAL is designed primarily for programming on-board computers, it is general enough to meet nearly all the needs in the production, verification and support of aerospace, and other real-time applications.

  6. Selective memory biases for words reflecting sex-specific body image concerns.

    Science.gov (United States)

    Unterhalter, Gina; Farrell, Simon; Mohr, Christine

    2007-08-01

    Women show "fear of fatness" and men a "drive for muscularity." Moreover, women perceive themselves as larger and men more muscular than they actually are. We tested potential memory biases congruent with these sex-specific body image concerns. Free recall performance for weight-related and muscle-related positive and negative words was assessed in 40 healthy undergraduate students (20 men). Men revealed a recall advantage for positive muscle words, while women showed a general advantage for positive and negative weight-related words. Thus, men revealed a memory bias congruent with their personal preference (more muscular), while women showed a general memory bias for weight information independent of their personal preference of being thinner. The absence of a positive memory bias in women might explain the higher incidence of body dissatisfaction and eating disorders in this population.

  7. Refining System Requirements to Program Specifications

    DEFF Research Database (Denmark)

    Olderog, Ernst-Ruediger; Ravn, Anders P.; Skakkebæk, Jens Ulrik

    1996-01-01

    A coherent and mathematically well-founded approach to the design ofreal-time and hybrid systems is presented.It covers requirementsanalysis and specification, design of controlling automatasatisfying the requirements, and derivation ofoccam-like communicating programs from these automata.......The generalized railroad crossing due to Heitmeyer and Lynchillustrates the approach.Requirements are analyzed within aconventional dynamic systems model of a plant, where states arefunctions of the reals, representing time. The requirements arespecified in an assumption-commitment style using Duration Calculus......,a real-time interval logic. Controlling real-time automata arespecified in the same formalism by elementaryconstraints on the plant states for each control state or phase.The Duration Calculus is used to verify that the control design refinesthe requirements.The real-time automata map smoothly...

  8. 29 CFR 99.235 - Program-specific audits.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Program-specific audits. 99.235 Section 99.235 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 99.235 Program-specific audits. (a) Program-specific audit guide available. In many cases, a program...

  9. 75 FR 23223 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Science.gov (United States)

    2010-05-03

    ... Animal and Plant Health Inspection Service Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public Meeting AGENCY: Animal and Plant Health Inspection Service... individuals and entities possessing, using, or transferring biological agents and toxins listed in 7 CFR 331.3...

  10. 76 FR 14896 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Science.gov (United States)

    2011-03-18

    ... Animal and Plant Health Inspection Service Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public Meeting AGENCIES: Animal and Plant Health Inspection Service... individuals and entities possessing, using, or transferring federally listed biological agents and toxins...

  11. 76 FR 17617 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Science.gov (United States)

    2011-03-30

    ... Animal and Plant Health Inspection Service Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public Meeting AGENCY: Animal and Plant Health Inspection Service... individuals and entities possessing, using, or transferring federally listed biological agents and toxins...

  12. Online Certificate Program Moves Participants to Advanced Stages of Concern for Social Marketing

    Science.gov (United States)

    Chaudhary, Anil Kumar; Warner, Laura A.; Stofer, Kathryn A.

    2017-01-01

    Social marketing is an underused strategy that agricultural educators can employ to bring about behavior change. We designed an online certificate program for Extension professionals and other educators based on an identified need for social marketing professional development. The Concerns-Based Adoption Model (CBAM) served as the conceptual…

  13. Presenting concerns of emerging adults seeking treatment at an early intervention outpatient mood and anxiety program.

    Science.gov (United States)

    Arcaro, Justin; Summerhurst, Carolyn; Vingilis, Evelyn; Wammes, Michael; Osuch, Elizabeth

    2017-09-01

    This study examined presenting concerns and characteristics of emerging adults (EAs) seeking treatment at an early intervention program for mood and anxiety disorders to better understand presenting concerns when treatment is needed. During an intake assessment conducted by a social worker or clinical psychologist, participants (N = 548; 62% female, 38% male) reported their top three current life concerns, which were analyzed qualitatively using thematic analysis. Participants completed a battery of questionnaires assessing demographic information, symptomatology, and daily functioning. Females presented with significantly higher levels of anxiety, and both females and younger individuals (age 16-18) presented with significantly higher levels of depression compared to males and older individuals (age 19-26), respectively. The two most commonly reported presenting concerns were problems in interpersonal relationships and academics, and females were more likely to report academic concerns than males. The majority of participants reported seeking help for a wide range of problems commonly faced by EAs (83.7%), and participants rarely expressed concerns about particular symptoms of mood and/or anxiety disorders (16.3%). EAs and those supporting EAs may benefit from learning when psychosocial concerns are indicative of mental health challenges warranting professional attention.

  14. Privacy Concerns Related to the Collection of Personal Information Under the Personal Identify Verification (PIV) Program

    Science.gov (United States)

    2008-03-01

    identity documents will lead to government tracking of individual movements within and throughout buildings. Specific concern has been noted that...subsequently be used to track purchases, transactions, preferences, and movement . As discussed previously in regard to surveillance, some fear that...articleID=16091179 8 Laban , J. (1996). Privacy issues surrounding personal identification systems. State of Connecticut: Department of Social Services

  15. Patient self-reported concerns in inflammatory bowel diseases: A gender-specific subjective quality-of-life indicator.

    Directory of Open Access Journals (Sweden)

    Valérie Pittet

    Full Text Available Patient-reported disease perceptions are important components to be considered within a holistic model of quality of care. Gender may have an influence on these perceptions. We aimed to explore gender-specific concerns of patients included in a national bilingual inflammatory bowel disease cohort.Following a qualitative study, we built a questionnaire comprising 37 items of concern. Answers were collected on a visual analog scale ranging from 0 to 100. Principal axis factor analysis was used to explore concern domains. Linear multiple regressions were conducted to assess associations with patient characteristics.Of 1102 patients who replied to the survey, 54% were female and 54% had Crohn's disease. We identified six domains of concern: socialization and stigmatization, disease-related constraints and uncertainty, symptoms and their impact on body and mind, loss of body control (including sexuality, disease transmission, and long-term impact of the disease. Cancer concerns were among the highest scored by all patients (median 61.8. Severity of symptoms was the only factor associated with concerns, unrelated to dimension and gender (p40 years decreased disease-related constraints and uncertainty concerns, and being at home or unemployed increased them. Treatments were associated with increased socialization and stigmatization and with increased disease-related constraints and uncertainty concerns in men. Overall, psychosomatic characteristics were highly associated with concerns for both men and women. Depending on the concern dimensions, increased levels of concern were associated with the highest signs of anxiety in women or depression in men, as well as lower health-related quality of life in men.Patients have numerous concerns related to their illness that need to be reassessed regularly. Concerns differ between men and women, suggesting that information and communication about the disease should take gender differences and subjective

  16. Patient self-reported concerns in inflammatory bowel diseases: A gender-specific subjective quality-of-life indicator.

    Science.gov (United States)

    Pittet, Valérie; Vaucher, Carla; Froehlich, Florian; Burnand, Bernard; Michetti, Pierre; Maillard, Michel H

    2017-01-01

    Patient-reported disease perceptions are important components to be considered within a holistic model of quality of care. Gender may have an influence on these perceptions. We aimed to explore gender-specific concerns of patients included in a national bilingual inflammatory bowel disease cohort. Following a qualitative study, we built a questionnaire comprising 37 items of concern. Answers were collected on a visual analog scale ranging from 0 to 100. Principal axis factor analysis was used to explore concern domains. Linear multiple regressions were conducted to assess associations with patient characteristics. Of 1102 patients who replied to the survey, 54% were female and 54% had Crohn's disease. We identified six domains of concern: socialization and stigmatization, disease-related constraints and uncertainty, symptoms and their impact on body and mind, loss of body control (including sexuality), disease transmission, and long-term impact of the disease. Cancer concerns were among the highest scored by all patients (median 61.8). Severity of symptoms was the only factor associated with concerns, unrelated to dimension and gender (pwomen, being >40 years decreased disease-related constraints and uncertainty concerns, and being at home or unemployed increased them. Treatments were associated with increased socialization and stigmatization and with increased disease-related constraints and uncertainty concerns in men. Overall, psychosomatic characteristics were highly associated with concerns for both men and women. Depending on the concern dimensions, increased levels of concern were associated with the highest signs of anxiety in women or depression in men, as well as lower health-related quality of life in men. Patients have numerous concerns related to their illness that need to be reassessed regularly. Concerns differ between men and women, suggesting that information and communication about the disease should take gender differences and subjective

  17. How can clinician-educator training programs be optimized to match clinician motivations and concerns?

    Directory of Open Access Journals (Sweden)

    McCullough B

    2015-01-01

    Full Text Available Brendan McCullough, Gregory E Marton, Christopher J Ramnanan Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada Background: Several medical schools have implemented programs aimed at supporting clinician-educators with formal mentoring, training, and experience in undergraduate medical teaching. However, consensus program design has yet to be established, and the effectiveness of these programs in terms of producing quality clinician-educator teaching remains unclear. The goal of this study was to review the literature to identify motivations and perceived barriers to clinician-educators, which in turn will improve clinician-educator training programs to better align with clinician-educator needs and concerns. Methods: Review of medical education literature using the terms “attitudes”, “motivations”, “physicians”, “teaching”, and “undergraduate medical education” resulted in identification of key themes revealing the primary motivations and barriers involved in physicians teaching undergraduate medical students. Results: A synthesis of articles revealed that physicians are primarily motivated to teach undergraduate students for intrinsic reasons. To a lesser extent, physicians are motivated to teach for extrinsic reasons, such as rewards or recognition. The key barriers deterring physicians from teaching medical students included: decreased productivity, lack of compensation, increased length of the working day, patient concerns/ethical issues, and lack of confidence in their own ability. Conclusion: Our findings suggest that optimization of clinician-educator training programs should address, amongst other factors, time management concerns, appropriate academic recognition for teaching service, and confidence in teaching ability. Addressing these issues may increase the retention of clinicians who are active and proficient in medical education. Keywords: clinician-educators, teaching, undergraduate medical

  18. Specific electrophysiological components disentangle affective sharing and empathic concern in psychopathy.

    Science.gov (United States)

    Decety, Jean; Lewis, Kimberly L; Cowell, Jason M

    2015-07-01

    Empathic impairment is one of the hallmarks of psychopathy, a personality dimension associated with poverty in affective reactions, lack of attachment to others, and a callous disregard for the feelings, rights, and welfare of others. Neuroscience research on the relation between empathy and psychopathy has predominately focused on the affective sharing and cognitive components of empathy in forensic populations, and much less on empathic concern. The current study used high-density electroencephalography in a community sample to examine the spatiotemporal neurodynamic responses when viewing people in physical distress under two subjective contexts: one evoking affective sharing, the other, empathic concern. Results indicate that early automatic (175-275 ms) and later controlled responses (LPP 400-1,000 ms) were differentially modulated by engagement in affective sharing or empathic concern. Importantly, the late event-related potentials (ERP) component was significantly impacted by dispositional empathy and psychopathy, but the early component was not. Individual differences in dispositional empathic concern directly predicted gamma coherence (25-40 Hz), whereas psychopathy was inversely modulatory. Interestingly, significant suppression in the mu/alpha band (8-13 Hz) when perceiving others in distress was positively associated with higher trait psychopathy, which argues against the assumption that sensorimotor resonance underpins empathy. Greater scores on trait psychopathy were inversely related to subjective ratings of both empathic concern and affective sharing. Overall, the study demonstrates that neural markers of affective sharing and empathic concern to the same cues of another's distress can be distinguished at an electrophysiological level, and that psychopathy alters later time-locked differentiations and spectral coherence associated with empathic concern. Copyright © 2015 the American Physiological Society.

  19. Specification and verification of GPGPU programs.

    OpenAIRE

    Blom, Stefan; Huisman, Marieke; Mihelcic, M.

    2014-01-01

    Abstract Graphics Processing Units (GPUs) are increasingly used for general-purpose applications because of their low price, energy efficiency and enormous computing power. Considering the importance of GPU applications, it is vital that the behaviour of GPU programs can be specified and proven correct formally. This paper presents a logic to verify GPU kernels written in OpenCL, a platform-independent low-level programming language. The logic can be used to prove both data-race-freedom and f...

  20. Patient self-reported concerns in inflammatory bowel diseases: A gender-specific subjective quality-of-life indicator.

    OpenAIRE

    Pittet, V.; Vaucher, C.; F. Froehlich; B. Burnand; Michetti, P.; Maillard, M. H.

    2017-01-01

    Patient-reported disease perceptions are important components to be considered within a holistic model of quality of care. Gender may have an influence on these perceptions. We aimed to explore gender-specific concerns of patients included in a national bilingual inflammatory bowel disease cohort. Following a qualitative study, we built a questionnaire comprising 37 items of concern. Answers were collected on a visual analog scale ranging from 0 to 100. Principal axis factor analysis was u...

  1. Patient self-reported concerns in inflammatory bowel diseases: A gender-specific subjective quality-of-life indicator

    OpenAIRE

    Pittet, Val?rie; Vaucher, Carla; Froehlich, Florian; Burnand, Bernard; Michetti, Pierre; Maillard, Michel H.

    2017-01-01

    Background Patient-reported disease perceptions are important components to be considered within a holistic model of quality of care. Gender may have an influence on these perceptions. We aimed to explore gender-specific concerns of patients included in a national bilingual inflammatory bowel disease cohort. Methods Following a qualitative study, we built a questionnaire comprising 37 items of concern. Answers were collected on a visual analog scale ranging from 0 to 100. Principal axis facto...

  2. Very Early Signs of Autism Reported by Parents Include Many Concerns Not Specific to Autism Criteria

    Science.gov (United States)

    Guinchat, Vincent; Chamak, Brigitte; Bonniau, Beatrice; Bodeau, Nicolas; Perisse, Didier; Cohen, David; Danion, Anne

    2012-01-01

    This study assessed parents' first concerns about their autistic child. This information was categorized so that it could help healthcare professionals improve early detection of autism. We designed a questionnaire using an open-ended format, and 459 questionnaires were completed by parents to assess difficulties encountered in obtaining a…

  3. Nutrition Labelling is a Trade Policy Issue: Lessons From an Analysis of Specific Trade Concerns at the World Trade Organization

    OpenAIRE

    Hawkes, C; Thow, A. M.; Jones, A; Ali, I.; Labonte, R

    2017-01-01

    Interpretive nutrition labels provide simplified nutrient-specific text and/or symbols on the front of pre-packaged foods, to encourage and enable consumers to make healthier choices. This type of labelling has been proposed as part of a comprehensive policy response to the global epidemic of non-communicable diseases. However, regulation of nutrition labelling falls under the remit of not just the health sector but also trade. Specific Trade Concerns have been raised at the World Trade Organ...

  4. Transmission Control Protocol, DARPA Internet Program Protocol Specification

    Science.gov (United States)

    1981-09-01

    particular a source or destination of messages from the point of view of the communicatio network. identification An Internet Protocol field. This...15-( RFC- 793 "* •TRANSMISSION CONTROL PROTOCOL ’-v DARPA INTERNET PROGRAM PROTOCOL SPECIFICATION September 1981 S... INTERNET PROGRAM PROTOCOL SPECIFICATION 1. INTRODUCTION The Transmission Control Protocol (TCP) is intended for use as a highly reliable host-to-host

  5. Iron supplements: scientific issues concerning efficacy and implications for research and programs.

    Science.gov (United States)

    Allen, Lindsay H

    2002-04-01

    Iron supplementation remains an important strategy for the prevention and treatment of iron deficiency anemia and can produce substantial improvements in the functional performance of iron deficient individuals and populations. Many potential benefits of iron supplementation require further exploration, including its effect on vitamin A and iodine metabolism. There is strong evidence that vitamin A and riboflavin deficiencies affect iron utilization from supplements and are important on a global scale, but little evidence that folate and vitamin B-12 deficiencies play a major causal role in the global burden of anemia. The efficacy of multiple micronutrient supplements for the prevention and treatment of anemia must be further evaluated. Because weekly supplementation with iron is effective at improving iron status, this option should be thoroughly explored and evaluated in the context of programs for the prevention and the treatment of iron deficiency and anemia. More conformation is warranted concerning the number of tablets that must be consumed in different situations, and the efficacy of supplying other micronutrients weekly with iron. Weekly supplementation programs may improve the logistical and economic constraints that currently limit the provision of supplements to the many target population groups for whom they are recommended, but usually fail to reach. Further work is required to clarify the purpose, delivery and outcomes of iron supplementation programs.

  6. Nutrition labelling is a trade policy issue: lessons from an analysis of specific trade concerns at the World Trade Organization.

    Science.gov (United States)

    Thow, Anne Marie; Jones, Alexandra; Hawkes, Corinna; Ali, Iqra; Labonté, Ronald

    2017-01-12

    Interpretive nutrition labels provide simplified nutrient-specific text and/or symbols on the front of pre-packaged foods, to encourage and enable consumers to make healthier choices. This type of labelling has been proposed as part of a comprehensive policy response to the global epidemic of non-communicable diseases. However, regulation of nutrition labelling falls under the remit of not just the health sector but also trade. Specific Trade Concerns have been raised at the World Trade Organization's Technical Barriers to Trade Committee regarding interpretive nutrition labelling initiatives in Thailand, Chile, Indonesia, Peru and Ecuador. This paper presents an analysis of the discussions of these concerns. Although nutrition labelling was identified as a legitimate policy objective, queries were raised regarding the justification of the specific labelling measures proposed, and the scientific evidence for effectiveness of such measures. Concerns were also raised regarding the consistency of the measures with international standards. Drawing on policy learning theory, we identified four lessons for public health policy makers, including: strategic framing of nutrition labelling policy objectives; pro-active policy engagement between trade and health to identify potential trade issues; identifying ways to minimize potential 'practical' trade concerns; and engagement with the Codex Alimentarius Commission to develop international guidance on interpretative labelling. This analysis indicates that while there is potential for trade sector concerns to stifle innovation in nutrition labelling policy, care in how interpretive nutrition labelling measures are crafted in light of trade commitments can minimize such a risk and help ensure that trade policy is coherent with nutrition action. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. [Lesbian, gay & grey : Specific needs and concerns of elderly homosexual women and men].

    Science.gov (United States)

    Misoch, Sabina

    2017-04-01

    In 2050 society will face the challenge of the effects of demographic changes with approximately 30 % of the Swiss population aged 65 years and older. This change will also lead to a higher number of elderly persons who identify themselves as homosexual and who live together with a same sex partner. In the year 2050 approximately 90,000-300,000 homosexual persons who are 65 years and older will live in Switzerland. This article shows that the current state of research in gerontology is characterized by large gaps regarding homosexuals and research in homosexuality regarding ageing. With a focus on the third and fourth ages of life for homosexuals of both sexes and based on the latest international research data this article shows that elderly homosexual people face specific challenges and have specific needs, which should be taken into account in home care services and nursing homes. Due to their lifestyles elderly homosexuals are often single and live alone, have no biological children and are afraid of being discriminated or stigmatized particularly in the case of their need for nursing. As a further aggravating factor, studies have shown that elderly homosexuals have poorer health conditions than heterosexuals with an increased need for care at an earlier stage in life.

  8. Reduction of Shape and Weight Concern in Young Adolescents: A 30-Month Controlled Evaluation of a Media Literacy Program

    Science.gov (United States)

    Wilksch, Simon M.; Wade, Tracey D.

    2009-01-01

    The effectiveness of a media literacy program in preventing eating disorders among adolescents is studied. Media literacy can be effective in helping reduce shape and weight concern and other eating disorder risk factors in adolescents over the long term.

  9. Consumer of concern early entry program (C-CEEP): protecting against the biological suicidal warfare host

    Science.gov (United States)

    Fish, Janet D.

    2014-05-01

    Man has used poisons for assassination purposes ever since the dawn of civilization, not only against individual enemies but also occasionally against armies. According to (Frischknecht, 2003)11 article on the History of Biological Warfare, during the past century, more than 500 million people died of infectious diseases. Several tens of thousands of these deaths were due to the deliberate release of pathogens or toxins. Two international treaties outlawed biological weapons in 1925 and 1972, but they have largely failed to stop countries from conducting offensive weapons research and large-scale production of biological weapons. Before the 20th century, biological warfare took on three main forms: (1) deliberate poisoning of food and water with infectious material, (2) use of microorganisms or toxins in some form of weapon system, and (3) use of biologically inoculated fabrics (Dire, 2013)8. This action plan is aimed at the recognition of the lack of current processes in place under an unidentified lead agency to detect, identify, track, and contain biological agents that can enter into the United States through a human host. This action plan program has been identified as the Consumer of Concern Early Entry Program or a simpler title is C-CEEP.

  10. Closing the Gap Between Specification and Programming: VDM++ and SCALA

    Science.gov (United States)

    Havelund, Klaus

    2011-01-01

    We argue that a modern programming language such as Scala offers a level of succinctness, which makes it suitable for program and systems specification as well as for high-level programming. We illustrate this by comparing the language with the Vdm++ specification language. The comparison also identifies areas where Scala perhaps could be improved, inspired by Vdm++. We furthermore illustrate Scala's potential as a specification language by augmenting it with a combination of parameterized state machines and temporal logic, defined as a library, thereby forming an expressive but simple runtime verification framework.

  11. Yucca mountain project getter program results(year 1):I-129 and other anions of concern.

    Energy Technology Data Exchange (ETDEWEB)

    Krumhansl, James Lee; Pless, Jason; Chwirka, J. Benjamin

    2006-07-01

    Although high level nuclear wastes (HLW) contain a daunting array of radioisotopes, only a restricted number are long-lived enough to be problematic, and of these many are either effectively insoluble or are likely to be scavenged from solution by minerals indigenous to all aquifers. Those few constituents likely to travel significant distances through aquifers either form colloids (and travel as particulates) or anions--which are not sorbed onto the predominantly negatively charged mineral surfaces. Iodine ({sup 129}I) is one such constituent and may travel as either iodide (I{sup -}) or iodate (IO{sub 3}{sup -}) depending on whether conditions are mildly reducing or oxidizing. Conventionally, {sup 99}Tc (traveling as TcO{sub 4}{sup -}) is regarded as being of greater concern since it is both more abundant and has a shorter half life (e.g., has a higher specific activity). However, it is unclear whether TcO{sub 4}{sup -} will ever actually form in the mildly reducing environments thought likely within degrading HLW canisters. Instead, technetium may remain reduced as highly insoluble Tc(IV), in which case {sup 129}I might become a significant risk driver in performance assessment (PA) calculations. In the 2004-2005 time frame the US Department of Energy (DOE)--Office of Civilian Radioactive Waste Management (OCRUM), Office of Science and Technology International (S&T) funded a program to identify ''getters'' for possible placement in the invert beneath HLW packages in the repository being planned by the Yucca Mountain Project (YMP). This document reports on progress made during the first (and only) year of this activity. The problem is not a new one and the project did not proceed in a complete vacuum of information. Potential leads came from past studies directed at developing anion getters for a near surface low-level waste facility at Hanford, which suggested that both copper-containing compounds and hydrotalcite-group minerals might be

  12. 38 CFR 41.235 - Program-specific audits.

    Science.gov (United States)

    2010-07-01

    ... will be available to provide specific guidance to the auditor with respect to internal control, compliance requirements, suggested audit procedures, and audit reporting requirements. The auditor should... available. When a current program-specific audit guide is available, the auditor shall follow GAGAS and the...

  13. Culturally and linguistically diverse students in health professional programs: an exploration of concerns and needs.

    Science.gov (United States)

    Gilligan, C; Outram, S

    2012-07-01

    Cultural diversity among students in tertiary institutions in Australia and globally has increased rapidly in the last decade, and is continuing to do so. Focus groups were held at the University of Newcastle, NSW to: (1) examine the specific needs of international students in the Master of Pharmacy, Bachelor of Medicine and Bachelor of Nursing programs in relation to language and cultural considerations and (2) to understand the attitudes of domestic students to the cultural issues faced among their peers. The project explored these issues with the intention to inform curricula changes to accommodate the needs of culturally and linguistically diverse students. The key themes emerging from international students were: difficulties in spoken language, differences in professional roles and expectations, differences in methods of learning, inadequate social interaction outside the classroom and acceptance of differences in cultural and religious practices. The domestic student views reinforced the comments from international students both in regard to social interaction and in regard to participation in class discussions. Although local students were interested in learning from international students about their culture and religious beliefs, there were limited initiatives from both sides. There is a need for tertiary institutions that benefit economically from increasing the numbers of international students to help them to study and live in a new environment. Assistance needs to go beyond learning the English language to helping students understand its use in a professional context (health terminology and slang used by patients), the nuances of the health professional disciplines in a western society, the approach to study and problem-based learning styles and skills to assist with social interaction. The results of the present exploration have led to a series of proposed actions for the University of Newcastle. These recommendations are applicable to any "Western

  14. [Social concern and the present state of intergenerational programs. An analysis of newspaper articles and a survey of organizations].

    Science.gov (United States)

    Murayama, Yoh; Takeuchi, Rumi; Ohba, Hiromi; Yasunaga, Masashi; Kuraoka, Masataka; Nonaka, Kumiko; Fujiwara, Yoshinori

    2013-03-01

    The objectives of this study were (1) to clarify changes in social concern in intergenerational programs and (2) to determine the current state of and issues affecting intergenerational programs. Articles including the words "intergenerational programs" were selected from 3 major Japanese newspapers (Asahi Shimbun, Yomiuri Shimbun, and Mainichi Shimbun) using an online database (399 articles). Content analysis was conducted to check changes in the number and content of articles. A total of 56 cases of intergenerational programs were selected, and a questionnaire survey was conducted with the responsible organization. The problems were classified using cluster analysis. Content analysis revealed that the number of articles relating to this topic increased towards the end of the 1990s, which corresponds with a change in social policy. The questionnaire survey revealed that most of the intergenerational programs were either annual or periodic activities. Furthermore, it was shown that the 4 main issues facing current intergenerational programs were the intergenerational gap, operating problems, activity selection, and lack of participants. In summary, social concern regarding the intergenerational programs has increased. However, most intergenerational programs were infrequent and quite time-intensive. Furthermore, the 4 issues mentioned above must be addressed in order to create programs that have wide-ranging benefits for each community. Resolving the problem of compartmentalized administration and appointing local coordinators is necessary to solve these problems.

  15. Northwest Energy Efficient Manufactured Housing Program Specification Development

    Energy Technology Data Exchange (ETDEWEB)

    Hewes, Tom [Northwest Energy Works of the Building America Partnership for Improved Residential Construction (BA-PIRC), Corvallis, OR (United States); Peeks, Brady [Northwest Energy Works of the Building America Partnership for Improved Residential Construction (BA-PIRC), Corvallis, OR (United States)

    2013-02-01

    The DOE research team Building America Partnership for Improved Residential Construction (BA-PIRC), Bonneville Power Administration (BPA), and Northwest Energy Works (NEW), the current Northwest Energy Efficient Manufactured Home Program (NEEM) program administrator, collaborated to research a new specification that would reduce the energy requirements of a NEEM home.This research identified and developed combinations of cost-effective high performance building assemblies and mechanical systems that can readily can be deployed in the manufacturing setting that reduce energy used for space conditioning, water heating and lighting by 50% over the present NEEM specifications.

  16. Survey of body donation programs in the US concerning the use of donor personal information with medical students.

    Science.gov (United States)

    Gerwer, Johanna; Gest, Thomas R

    2017-05-01

    Body donor programs need to balance ethical concerns and educational needs. Among donor programs in the US, there is variability in the amount of donor personal information that is provided to medical students. This study assesses this variability and investigates the reasons for the variability among donor programs. Telephone interviews and email surveys were used to collect information concerning the provision and use of donor personal information with medical students. One hundred fifty-one donor programs in the US were contacted via email or telephone interview or both. Fifty-three donor programs responded to the survey or participated in the telephone interview. The survey results show variation, not only in the amount of donor personal information provided to medical students, but also in the attitudes and beliefs of the donor program personnel concerning donor personal information. This research documents the variability of the educational use of donor personal information. It is hoped that this description of the various approaches to using donor information will encourage the ethical use of donor information within the context of medical education. Clin. Anat. 30:445-449, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  17. A Review of Problems Concerning the Granting of Transfer of Credit for Undergraduate Study Abroad Programs.

    Science.gov (United States)

    Frey, James S.

    This review examines the various undergraduate study abroad programs and the problems involved in evaluating the programs for the granting of transfer credits. The five major factors influencing the credit evaluation decision are enumerated, and their importance is discussed. (MML)

  18. False-positive findings in mammography screening induces short-term distress - breast cancer-specific concern prevails longer

    DEFF Research Database (Denmark)

    Aro, A R; Pilvikki Absetz, S; van Elderen, T M

    2000-01-01

    -ups at 2 and 12 months postscreening. At 2 months, there was a moderate multivariate effect of group on distress; and intrusive thinking and worry about breast cancer, in particular, were most frequent amongst the false positives. Intrusive thinking still prevailed at 12 months, in addition to a higher...... findings (n=1407), false-positive findings (n=492) and referents from outside the screening programme (n=1718, age 48-49 years). Distress was measured as illness worry, anxiety, depression, cancer beliefs and early detection behaviour. Measurements were one month before screening invitation with follow...... perceived breast cancer risk and susceptibility. Distress related to screening and false-positive findings seems to be moderate, but prevailing cancer-specific concerns call for improvements in screening programmes....

  19. Irritating, shocking, and intolerable TV programs: Norms, values, and concerns of viewers in the Netherlands

    NARCIS (Netherlands)

    Heuvelman, A.; Peeters, A.L.; Dijk, J.A.G.M. van

    2005-01-01

    This study investigates the negative reactions of Dutch viewers to the content of television programs. The results show that a vast majority is sometimes irritated by TV programs, that a somewhat smaller majority is sometimes shocked by the programs, and that one fifth of the viewing population

  20. A Domain-Specific Programming Language for Secure Multiparty Computation

    DEFF Research Database (Denmark)

    Nielsen, Janus Dam; Schwartzbach, Michael Ignatieff

    2007-01-01

    We present a domain-specific programming language for Secure Multiparty Computation (SMC). Information is a resource of vital importance and considerable economic value to individuals, public administration, and private companies. This means that the confidentiality of information is crucial, but...... application development. The language is implemented in a prototype compiler that generates Java code exploiting a distributed cryptographic runtime....

  1. Development of synthetic analysis program concerning on the safety of energy resources

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S. H.; Choi, S. S.; Cheong, Y. H.; Ahn, S. H.; Chang, W. J. [Atomic Creative Technology, Daejeon (Korea, Republic of)

    2007-03-15

    Methodology development of synthetic analysis of energy resources: build system methodology of synthetic analysis of energy resources. Development of web-based enquete program, develop web-based enquete program to support synthetic analysis of energy resources. Aggregation Software development, develop AHP algorithm and aggregation software for the synthetic analysis of energy resources.

  2. Some Policy and Program Implications of an Overview of Research Concerning Adolescent Sexuality.

    Science.gov (United States)

    Chilman, Catherine S.

    There is great public concern about illegitimate births among adolescents. The consequences of this early illegitimate childbirth have been treated in a simplistic manner to date. Several causes of the problems are: (1) young adolescents fail to prevent pregnancy when they feel there is little future or reward for them in society; (2) teenagers…

  3. Integration of a specific nutrition program into a comprehensive program of therapeutic education

    OpenAIRE

    Trolonge, Stanislas; Idier, Laetitia; Larroumet, Nicole; Lespinasse, Lucille; Capdepon, Laurence; Dos Reis, Sandra; Chauveau, Philippe

    2012-01-01

    Nutritional education strategies should be included in a multidisciplinary team for therapeutic education (TPE). We conduct a comprehensive program of therapeutic education for out-center hemodialysis patients. 5 education workshops were performed during dialysis sessions, every 15 days: Illness experience (psychologist), vascular access (nurses), medication management (pharmacist), nutrition management (dietitian) and final evaluation. A specific program of nutrition (EDAM project: Educat...

  4. Mutant-specific gene programs in the zebrafish

    OpenAIRE

    Weber, Gerhard J.; Choe, Sung E; Dooley, Kimberly A.; Paffett-Lugassy, Noëlle N.; Zhou, Yi; Zon, Leonard I.

    2005-01-01

    Hematopoiesis involves the production of stem cells, followed by the orchestrated differentiation of the blood lineages. Genetic screens in zebrafish have identified mutants with defects that disrupt specific stages of hematopoiesis and vasculogenesis, including the cloche, spadetail (tbx16), moonshine (tif1g), bloodless, and vlad tepes (gata1) mutants. To better characterize the blood program, gene expression profiling was carried out in these mutants and in scl-morphants (scl mo). Distinct ...

  5. Toxicological benchmarks for screening potential contaminants of concern for effects on terrestrial plants. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Suter, G.W. II; Will, M.E.; Evans, C.

    1993-09-01

    One of the initial stages in ecological risk assessment for hazardous waste sites is the screening of contaminants to determine which of them are worthy of further consideration as ``contaminants of potential concern.`` This process is termed ``contaminant screening.`` It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to plants. This report presents a standard method for deriving benchmarks for this purpose (phytotoxicity benchmarks), a set of data concerning effects of chemicals in soil or soil solution on plants, and a set of phytotoxicity benchmarks for 34 chemicals potentially associated with US Department of Energy (DOE) sites. Chemicals that are found in soil at concentrations exceeding both the phytotoxicity benchmark and the background concentration for the soil type should be considered contaminants of potential concern. The purpose of this report is to present plant toxicity data and discuss their utility as benchmarks for determining the hazard to terrestrial plants caused by contaminants in soil. Benchmarks are provided for soils and solutions.

  6. Do universal media literacy programs have an effect on weight and shape concern by influencing media internalization?

    Science.gov (United States)

    Wade, Tracey D; Wilksch, Simon M; Paxton, Susan J; Byrne, Susan M; Austin, S Bryn

    2017-07-01

    The current study examined whether media internalization, found to mediate the relationship between selected prevention programs and outcomes, mediated the impact of two universal prevention programs that targeted risk factors for eating disorders and obesity, namely weight concern, and shape concern. Students randomized to a media literacy (Media Smart) program (N = 269, 65% females, mean age 12.97 years) and a healthy lifestyle (Life Smart) program (N = 347, 69% females, mean age 13.07 years) were included in the analyses. There were four waves of data (baseline, end of intervention, 6- and 12-month follow-up). Latent growth curve modeling was used to explore whether group assignment influenced levels of media internalization, and whether that in turn influenced change over time of our two outcome variables. Being randomly allocated to Media Smart as opposed to Life Smart resulted in less growth of both outcome variables through the influence on decreasing levels of media internalization. Findings provided support for the suggestion that media literacy programs exert an impact on outcomes related to eating disorder risk through changes to media internalization. Future research should examine whether these mechanisms of change differ between girls and boys. © 2017 Wiley Periodicals, Inc.

  7. Arkansas Principals' Attitudes Concerning the Program for Effective Teaching Model (Hunter Model).

    Science.gov (United States)

    Terry, Paul M.

    This study was conducted to compare the attitudes of Arkansas elementary and secondary school principals toward the Madeline Hunter clinical supervision model "Program for Effective Teaching (PET)." A survey instrument titled "Attitudes of Principals Toward PET" was mailed to every elementary and secondary public school…

  8. Perspectives and Future Directions Concerning Fresh, Whole Foods in Montana School Nutrition Programs

    Science.gov (United States)

    Stephens, Lacy; Byker Shanks, Carmen J.; Roth, Aubree; Bark, Katie

    2015-01-01

    Purpose/Objectives: To meet new USDA school meal standards, school nutrition programs may need to transition from a "heat and serve" meal preparation approach to increased scratch cooking and use of fresh, whole foods. This study aims to assess the attitudes, motivations, and barriers for Montana school nutrition professionals and key…

  9. Gene program-specific regulation of PGC-1{alpha} activity

    DEFF Research Database (Denmark)

    Schmidt, Søren F; Mandrup, Susanne

    2011-01-01

    Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1 α (PGC-1α) activation coordinates induction of the hepatic fasting response through coactivation of numerous transcription factors and gene programs. In the June 15, 2011, issue of Genes & Development, Lustig and colleagues (pp....... 1232-1244) demonstrated that phosphorylation of PGC-1α by the p70 ribosomal protein S6 kinase 1 (S6K1) specifically interfered with the interaction between PGC-1α and HNF4α in liver and blocked the coactivation of the gluconeogenic target genes. This demonstrates how independent fine-tuning of gene...

  10. Space Research and Technology Program: Program and specific objectives, document approval

    Science.gov (United States)

    1982-01-01

    A detailed view of the Space Research and Technology program work breakdown structure is provided down to the specific objective level. Goals or objectives at each of these levels are set forth. The specific objective narratives are structured into several parts. First, a short paragraph statement of the specific objective is given. This is followed by a list of subobjectives. A list of targets is then provided for those areas of the specific objective that are amenable to a quantitative description of technical accomplishment and schedule. Fluid and thermal physics, materials and structures, computer science and electronics, space energy conversion, multidisciplinary research, controls and human factors, chemical propulsion, spacecraft systems, transportation systems, platform systems, and spacecraft systems technology comprise the principal research programs.

  11. Constipation-related symptoms and bowel program concerning individuals with spinal cord injury.

    Science.gov (United States)

    Harari, D; Sarkarati, M; Gurwitz, J H; McGlinchey-Berroth, G; Minaker, K L

    1997-06-01

    To determine the prevalence of constipation-related symptoms in individuals with chronic spinal cord injury (SCI), to describe the bowel program as reported by patients and including use of bowel medications and evacuation techniques, and to examine the clinical, functional and pharmacological risks of difficulty with evacuation. This is a cross-sectional study of all in-patients at least 3 months beyond acute injury, on the West Roxbury/Brockton VAMC SCI Service, during a 10 month period (n = 197). Clinical, functional, and medication data were abstracted from medical and nursing records. Individual interviews were conducted with all available participants (n = 161, 82%) regarding bowel-related symptoms and treatment over the previous 1 month period. The study definition of difficulty with evacuation was spending more than 1 h per episode of bowel evacuation. Forty-one percent of the 161 interview responders spent more than 1 h on bowel evacuation, 50% reported abdominal distension and 38% reported abdominal pain, 27% reported headaches or sweats relieved by having a bowel movement, and 33% reported fecal incontinence at least once a month. The bisacodyl suppository was the most commonly used laxative agent, while docusate was the most popular oral agent. Subjects with difficulty with evacuation (n = 66) were compared with those who spent less than 1 h on evacuation (n = 95). Factors associated with difficulty with evacuation were tetraplegia, Frankel grade A/B, laxative use, polypharmacy, previous urinary outlet surgery, and symptoms of abdominal pain and distension. Constipation-related symptoms are highly prevalent in individuals with spinal cord injury, despite considerable laxative use. Our findings suggest that difficulty with evacuation can be predicted on the basis of a patient's clinical profile.

  12. Designing monitoring programs for chemicals of emerging concern in potable reuse ⋯ What to include and what not to include?

    KAUST Repository

    Drewes, Jorg

    2012-11-01

    This study discussed a proposed process to prioritize chemicals for reclaimed water monitoring programs, selection of analytical methods required for their quantification, toxicological relevance of chemicals of emerging concern regarding human health, and related issues. Given that thousands of chemicals are potentially present in reclaimed water and that information about those chemicals is rapidly evolving, a transparent, science-based framework was developed to guide prioritization of which compounds of emerging concern (CECs) should be included in reclaimed water monitoring programs. The recommended framework includes four steps: (1) compile environmental concentrations (e.g., measured environmental concentration or MEC) of CECs in the source water for reuse projects; (2) develop a monitoring trigger level (MTL) for each of these compounds (or groups thereof) based on toxicological relevance; (3) compare the environmental concentration (e.g., MEC) to the MTL; CECs with a MEC/MTL ratio greater than 1 should be prioritized for monitoring, compounds with a ratio less than \\'1\\' should only be considered if they represent viable treatment process performance indicators; and (4) screen the priority list to ensure that a commercially available robust analytical method is available for that compound. © IWA Publishing 2013.

  13. Reasons for non-participation in a parental program concerning underage drinking: a mixed-method study

    Directory of Open Access Journals (Sweden)

    Eriksson Charli

    2009-12-01

    Full Text Available Abstract Background Alcohol consumption among adolescents is a serious public health concern. Research has shown that prevention programs targeting parents can help prevent underage drinking. The problem is that parental participation in these kinds of interventions is generally low. Therefore, the aim of the present study is to examine non-participation in a parental support program aiming to prevent underage alcohol drinking. The Health Belief Model has been used as a tool for the analysis. Methods To understand non-participation in a parental program a quasi-experimental mixed-method design was used. The participants in the study were invited to participate in a parental program targeting parents with children in school years 7-9. A questionnaire was sent home to the parents before the program started. Two follow-up surveys were also carried out. The inclusion criteria for the study were that the parents had answered the questionnaire in school year 7 and either of the questionnaires in the two subsequent school years (n = 455. Multinomial logistic regression analysis was used to examine reasons for non-participation. The final follow-up questionnaire included an opened-ended question about reasons for non-participation. A qualitative content analysis was carried out and the two largest categories were included in the third model of the multinomial logistic regression analysis. Results Educational level was the most important socio-demographic factor for predicting non-participation. Parents with a lower level of education were less likely to participate than those who were more educated. Factors associated with adolescents and alcohol did not seem to be of significant importance. Instead, program-related factors predicted non-participation, e.g. parents who did not perceive any need for the intervention and who did not attend the information meeting were more likely to be non-participants. Practical issues, like time demands, also seemed to

  14. Developing Form Assembly Specifications for Exams with Multiple Choice and Constructed Response Items: Balancing Reliability and Validity Concerns

    Science.gov (United States)

    Hendrickson, Amy; Patterson, Brian; Ewing, Maureen

    2010-01-01

    The psychometric considerations and challenges associated with including constructed response items on tests are discussed along with how these issues affect the form assembly specifications for mixed-format exams. Reliability and validity, security and fairness, pretesting, content and skills coverage, test length and timing, weights, statistical…

  15. Vocational Education, a Current Concern.

    Science.gov (United States)

    Partridge, Susan

    Vocational education is needed for a strong economy, and the decline in vocational education enrollment is a serious concern. One recommendation is for more specific job training in the United States at the high school level, comparable to the apprenticeship programs in West Germany. Through the years, as certain needs have become apparent,…

  16. Fear, familiarity, and the perception of risk: a quantitative analysis of disaster-specific concerns of paramedics.

    Science.gov (United States)

    Smith, Erin C; Burkle, Frederick M; Archer, Frank L

    2011-03-01

    Paramedics play an integral role in the response to and management of disasters and mass casualty events. Providing a core component of the front line response to disasters, paramedics potentially expose themselves to a variety of health and safety risks, including physical injury, death, communicable disease, and psychological effects. The health and safety risks to emergency service personnel were highlighted by the deaths of firefighters, paramedics, and police during the September 11, 2001, terrorist attacks, and the infection, illness, and deaths of paramedics and emergency health care staff during the severe acute respiratory syndrome outbreak in 2003. Given that a willing and able prehospital workforce is a vital component of any successful response to a disaster situation, the present study explored paramedics' perception of risk and willingness to work, with a specific focus on identifying which type of disasters that paramedics associate with greater levels of fear, familiarity, and risk. A total of 175 paramedics completed a survey ranking 40 disaster scenarios for levels of fear and familiarity. The results indicate that paramedics ranked nuclear and radiological events and outbreaks of new and highly infectious disasters highest for fear and unfamiliarity. This has implications for preparedness, education, and training. ©2011 American Medical Association. All rights reserved.

  17. 47 CFR 76.75 - Specific EEO program requirements.

    Science.gov (United States)

    2010-10-01

    ... informing prospective employees that discrimination because of race, color, religion, national origin, age..., religion, age, or gender. (i) An employment unit shall use recruitment sources for each vacancy sufficient... programming distributor employment issues, including conventions, career days, workshops, and similar...

  18. Yucca Mountain Project Getter Program Results (Year 1) I-I29 and Other Anions of Concern

    Energy Technology Data Exchange (ETDEWEB)

    J.L. Krumhansl; J.D. Pless; J.B. Chwirka; K.C. Holt

    2006-07-17

    Although high level nuclear wastes (HLW) contain a daunting array of radioisotopes, only a restricted number are long-lived enough to be problematic, and of these many are either effectively insoluble or are likely to be scavenged from solution by minerals indigenous to all aquifers. Those few constituents likely to travel significant distances through aquifers either form colloids (and travel as particulates) or anions--which are not sorbed onto the predominantly negatively charged mineral surfaces. Iodine ({sup 129}I) is one such constituent and may travel as either iodide (I{sup -}) or iodate (IO{sub 3}{sup -}) depending on whether conditions are mildly reducing or oxidizing. Conventionally, {sup 99}Tc (traveling as TcO{sub 4}{sup 0}) is regarded as being of greater concern since it is both more abundant and has a shorter half life (e.g., has a higher specific activity). However, it is unclear whether TcO{sub 4}{sup -} will ever actually form in the mildly reducing environments thought likely within degrading HLW canisters. Instead, technetium may remain reduced as highly insoluble Tc(lV), in which case {sup 129}I might become a significant risk driver in performance assessment (PA) calculations. In the 2004-2005 time frame the US Department of Energy (DOE)--Office of Civilian Radioactive Waste Management (OCRUM), Office of Science and Technology International (S&T) funded a program to identify ''getters'' for possible placement in the invert beneath HLW packages in the repository being planned by the Yucca Mountain Project (YMP). This document reports on progress made during the first (and only) year of this activity. The problem is not a new one and the project did not proceed in a complete vacuum of information. Potential leads came from past studies directed at developing anion getters for a near surface low-level waste facility at Hanford, which suggested that both copper-containing compounds and hydrotalcite-group minerals might be

  19. Aeronautics research and technology program and specific objectives

    Science.gov (United States)

    1981-01-01

    Aeronautics research and technology program objectives in fluid and thermal physics, materials and structures, controls and guidance, human factors, multidisciplinary activities, computer science and applications, propulsion, rotorcraft, high speed aircraft, subsonic aircraft, and rotorcraft and high speed aircraft systems technology are addressed.

  20. Aeronautics Research and Technology Program and specific objectives, fiscal year 1982

    Science.gov (United States)

    Olstad, W. B.

    1981-01-01

    The Aeronautics Research and Technology program is broken down into two program areas (research and technology base, and systems technology programs) which are further broken down into succeedingly more detailed activities to form a work breakdown structure for the aeronautics program: program area, program/discipline objective, specific objective, and research and technology objective and plan (RTOP). A detailed view of this work breakdown structure down to the specific objective level is provided, and goals or objectives at each of these levels are set forth. What is to be accomplished and why are addressed, but not how. The letter falls within the domain of the RTOP.

  1. High Performance Computing - Power Application Programming Interface Specification.

    Energy Technology Data Exchange (ETDEWEB)

    Laros, James H.,; Kelly, Suzanne M.; Pedretti, Kevin; Grant, Ryan; Olivier, Stephen Lecler; Levenhagen, Michael J.; DeBonis, David

    2014-08-01

    Measuring and controlling the power and energy consumption of high performance computing systems by various components in the software stack is an active research area [13, 3, 5, 10, 4, 21, 19, 16, 7, 17, 20, 18, 11, 1, 6, 14, 12]. Implementations in lower level software layers are beginning to emerge in some production systems, which is very welcome. To be most effective, a portable interface to measurement and control features would significantly facilitate participation by all levels of the software stack. We present a proposal for a standard power Application Programming Interface (API) that endeavors to cover the entire software space, from generic hardware interfaces to the input from the computer facility manager.

  2. Northwest Energy Efficient Manufactured Housing Program Specification Development

    Energy Technology Data Exchange (ETDEWEB)

    Hewes, T.; Peeks, B.

    2013-02-01

    The Hood River Passive Project was developed by Root Design Build of Hood River Oregon using the Passive House Planning Package (PHPP) to meet all of the requirements for certification under the European Passive House standards. The Passive House design approach has been gaining momentum among residential designers for custom homes and BEopt modeling indicates that these designs may actually exceed the goal of the U.S. Department of Energy's (DOE) Building America program to reduce home energy use by 30%-50% (compared to 2009 energy codes for new homes). This report documents the short term test results of the Shift House and compares the results of PHPP and BEopt modeling of the project.

  3. A Functional-Notional Approach for English for Specific Purposes (ESP) Programs.

    Science.gov (United States)

    Kim, Young-Min

    English for Specific Purposes (ESP) programs, characterized by the special needs of the language learners, are described and a review of the literature on a functional-notional approach to the syllabus design of ESP programs is presented. It is suggested that effective ESP programs should teach the language skills necessary to function and perform…

  4. The Relationship between Institutional, Departmental and Program-Specific Variables and the Academic Performance of Division I FBS Football Programs

    Science.gov (United States)

    Eigenbrot, Steven C.

    2012-01-01

    This study investigated the connection between the academic evaluation of Division I FBS football programs and the various social settings that influenced these student-athletes. These social settings were classified as: institutional, departmental and program-specific. The experience of the student-athlete is thought to be impacted by all three…

  5. Residential Treatment Programs: Concerns Regarding Abuse and Death in Certain Programs for Troubled Youth. Testimony before the Committee on Education and Labor, House of Representatives. GAO-08-146T

    Science.gov (United States)

    Kutz, Gregory D.; O'Connell, Andy

    2007-01-01

    Residential treatment programs provide a range of services, including drug and alcohol treatment, confidence building, military-style discipline, and psychological counseling for troubled boys and girls with a variety of addiction, behavioral, and emotional problems. This testimony concerns programs across the country referring to themselves as…

  6. Construction and Verification of PLC LD-programs by LTL-specification

    Directory of Open Access Journals (Sweden)

    E. V. Kuzmin

    2013-01-01

    Full Text Available An approach to construction and verification of PLC LD-programs for discrete problems is proposed. For the specification of the program behavior, we use the linear-time temporal logic LTL. Programming is carried out in the LD-language (Ladder Diagram according to an LTL-specification. The correctness analysis of an LTL-specification is carried out by the symbolic model checking tool Cadence SMV. A new approach to programming and verification of PLC LD-programs is shown by an example. For a discrete problem, we give a LD-program, its LTL-specification and an SMV-model. The purpose of the article is to describe an approach to programming PLC, which would provide a possibility of LD-program correctness analysis by the model checking method. Under the proposed approach, the change of the value of each program variable is described by a pair of LTL-formulas. The first LTL-formula describes situations which increase the value of the corresponding variable, the second LTL-formula specifies conditions leading to a decrease of the variable value. The LTL-formulas (used for speci- fication of the corresponding variable behavior are constructive in the sense that they construct the PLC-program (LD-program, which satisfies temporal properties expressed by these formulas. Thus, the programming of PLC is reduced to the construction of LTLspecification of the behavior of each program variable. In addition, an SMV-model of a PLC LD-program is constructed according to LTL-specification. Then, the SMV-model is analysed by the symbolic model checking tool Cadence SMV.

  7. NASIS data base management system - IBM 360/370 OS MVT implementation. 4: Program design specifications

    Science.gov (United States)

    1973-01-01

    The design specifications for the programs and modules within the NASA Aerospace Safety Information System (NASIS) are presented. The purpose of the design specifications is to standardize the preparation of the specifications and to guide the program design. Each major functional module within the system is a separate entity for documentation purposes. The design specifications contain a description of, and specifications for, all detail processing which occurs in the module. Sub-modules, reference tables, and data sets which are common to several modules are documented separately.

  8. Afghan National Security Forces: Despite Reported Successes, Concerns Remain about Literacy Program Results, Contract Oversight, Transition, and Sustainment

    Science.gov (United States)

    2014-01-01

    Special Inspector General for Afghanistan Reconstruction (SIGAR), 1550 Crystal Drive, Suite 900 (Attn: Ms. Gabriele Tonsil ), Arlington, VA 22202...ACKNOWLEDGMENTS Gabriele Tonsil , Senior Audit Manager Clifton Spruill, Analyst-in-Charge Vicki McClure, Senior Program Analyst Donnalee Scharschmidt, Program

  9. 77 FR 4300 - Notice of Data Availability Concerning Renewable Fuels Produced From Palm Oil Under the RFS Program

    Science.gov (United States)

    2012-01-27

    ... the two types of biofuel shows that ] biodiesel and renewable diesel produced from palm oil have... Energy.\\13\\ It has been used to model land cover changes across the world in many different ecosystems... AGENCY Notice of Data Availability Concerning Renewable Fuels Produced From Palm Oil Under the RFS...

  10. Outcomes of three different models for sex education and citizenship programs concerning knowledge, attitudes, and behavior of Brazilian adolescents

    Directory of Open Access Journals (Sweden)

    Campos Márcia

    2005-01-01

    Full Text Available Three different school-based sex education and citizenship programs in public schools in Rio de Janeiro, Belo Horizonte, and Salvador, Brazil, were evaluated in a cross-sectional study comparing knowledge, attitudes, and practices in sexuality, citizenship, and gender issues among adolescents participating in the programs' activities as compared to adolescents enrolled in schools without such programs (controls. Results showed that Salvador's program achieved good results, with significant changes in knowledge on sexuality and reproductive physiology, attitudes regarding citizenship, and current use of modern contraceptives; Rio de Janeiro's program succeeded in improving students' knowledge of reproductive physiology and attitudes towards sexuality; Belo Horizonte's participants showed greater knowledge of reproductive physiology and STI/HIV prevention but had less positive attitudes towards gender issues, while reporting greater sexual activity. The main difference between Salvador's program and the others was the focus on creative and cultural activities; Belo Horizonte's main difference was its lack of interaction with health services and professionals. However, after the evaluation Belo Horizonte reframed its educational strategies and launched a scaling-up process in a joint effort with the health and school systems.

  11. Identifying and understanding the concerns of business: a systematic approach to the development of the Australian WorkHealth Program - Arthritis.

    Science.gov (United States)

    Reavley, Nicola; Livingston, Jenni; Buchbinder, Rachelle; Osborne, Richard

    2012-07-01

    The aim of the Australian WorkHealth Program - Arthritis was to develop and test an education program designed to minimise risk of arthritis and prevent or reduce absenteeism and presenteeism. The objective of the current study was to use a wide-ranging, multifaceted and interactive approach to engage with stakeholders in order to inform the content and delivery of the intervention. Methods used to inform program design included a concept mapping workshop, interviews, surveys, a steering committee and an industry advisory group. Engaging with a wide range of stakeholders in multiple ways early in program development allowed for the comparison and verification of data to obtain a better overall picture of the needs of participants. It also offered the opportunity to share 'ownership' of the program with stakeholders by generating a program that was tailored to their ethos and needs. The stakeholder engagement process was instrumental in building commitment to the program and establishing an overarching model of action. Interview and survey data indicated that awareness of arthritis was low and musculoskeletal disorders more generally were of greater concern. It was agreed that programs should be relevant, evidence-based, involve senior management education, incorporate a business case, and involve tailored implementation and marketing strategies. The qualitative preparatory phase as well as all the engagement work was key to informing program design. The approach taken in this study has the potential to inform a wide range of workplace interventions. Engaging with a wide range of stakeholders in multiple ways from program inception allowed for the comparison and verification of information to permit the generation of a model of intervention that had the highest possible chance of success. It offered the opportunity to not only define program content and implementation processes, but to build genuine 'ownership' of the program.

  12. HAL/SM language specification. [programming languages and computer programming for space shuttles

    Science.gov (United States)

    Williams, G. P. W., Jr.; Ross, C.

    1975-01-01

    A programming language is presented for the flight software of the NASA Space Shuttle program. It is intended to satisfy virtually all of the flight software requirements of the space shuttle. To achieve this, it incorporates a wide range of features, including applications-oriented data types and organizations, real time control mechanisms, and constructs for systems programming tasks. It is a higher order language designed to allow programmers, analysts, and engineers to communicate with the computer in a form approximating natural mathematical expression. Parts of the English language are combined with standard notation to provide a tool that readily encourages programming without demanding computer hardware expertise. Block diagrams and flow charts are included. The semantics of the language is discussed.

  13. The Rise of International Relations Programs in the Brazilian Federal Universities: Curriculum Specificities and Current Challenges

    Science.gov (United States)

    Ferreira, Marcos Alan S. V.

    2016-01-01

    The aim of this reflection is to study the new international relations (IR) programs introduced by Brazilian federal universities, looking comparatively at their curriculum specificities and current challenges. In recent years, Brazil has seen an increase of IR programs launched in several regions. Since 2003, the Ministry of Education is in the…

  14. Nurturing the Relationships of All Couples: Integrating Lesbian, Gay, and Bisexual Concerns into Premarital Education and Counseling Programs

    Science.gov (United States)

    Casquarelli, Elaine J.; Fallon, Kathleen M.

    2011-01-01

    Research shows that premarital counseling programs help engaged couples develop interpersonal and problem-solving skills that enhance their marital relationships. Yet, there are limited services for same-sex couples. This article assumes an integrated humanistic and social justice advocacy stance to explore the needs of lesbian, gay, and bisexual…

  15. Improved in silico prediction of carcinogenic potency (TD50) and the risk specific dose (RSD) adjusted Threshold of Toxicological Concern (TTC) for genotoxic chemicals and pharmaceutical impurities.

    Science.gov (United States)

    Contrera, Joseph F

    2011-02-01

    The Threshold of Toxicological Concern (TTC) is a level of exposure to a genotoxic impurity that is considered to represent a negligible risk to humans. The TTC was derived from the results of rodent carcinogenicity TD50 values that are a measure of carcinogenic potency. The TTC currently sets a default limit of 1.5 μg/day in food contact substances and pharmaceuticals for all genotoxic impurities without carcinogenicity data. Bercu et al. (2010) used the QSAR predicted TD50 to calculate a risk specific dose (RSD) which is a carcinogenic potency adjusted TTC for genotoxic impurities. This promising approach is currently limited by the software used, a combination of MC4PC (www.multicase.com) and a Lilly Inc. in-house software (VISDOM) that is not available to the public. In this report the TD50 and RSD were predicted using a commercially available software, SciQSAR (formally MDL-QSAR, www.scimatics.com) employing the same TD50 training data set and external validation test set that was used by Bercu et al. (2010). The results demonstrate the general applicability of QSAR predicted TD50 values to determine the RSDs for genotoxic impurities and the improved performance of SciQSAR for predicting TD50 values. Copyright © 2010 Elsevier Inc. All rights reserved.

  16. Going Concern eller Concerned Going

    DEFF Research Database (Denmark)

    Haraszuk, Anni; Hartmann, Stig

    2012-01-01

    Højsæsonen for revision af årsrapporter 2011 er på trapperne; men hvordan håndterer revisorer egentlig going concern i praksis - i en tid præget af stejle op- og nedture?......Højsæsonen for revision af årsrapporter 2011 er på trapperne; men hvordan håndterer revisorer egentlig going concern i praksis - i en tid præget af stejle op- og nedture?...

  17. A Method, Computer Program and System for Inferring Relations Between Cultural Specific Concepts in Two Cultures

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention relates to a method, computer program and system for inferring relations between cultural specific concepts (CSC) in two cultures at least comprising the steps of - extracting and listing said cultural specific concepts (CSCs) and features of said CSCs from at least a first...

  18. Computer Program Development Specification for IDAMST Operational Flight Programs. Addendum 1. Executive Software.

    Science.gov (United States)

    1976-11-01

    establishes the requirements for performance and design of the Executive Software for the Integrated Diqital Avionics for a Medium Short Takeoff and Landing...system design . a. System Specification for IDAMST, Type A (S1-1010), June 1976. b. Prime Item Development Specification, IDAMST Processor, Type Bl (Sl...This bit shall be set to logic 1, in Master Mooc onjy, cafer receiving an excepted, valid status word associzeo witn a Remote device in Transmit Mooe

  19. A Stochastic Programming Model for Decision-Making Concerning Medical Supply Location and Allocation in Disaster Management.

    Science.gov (United States)

    Barri Khojasteh, Samad; Macit, Irfan

    2017-06-05

    We propose a stochastic programming model as a solution for optimizing the problem of locating and allocating medical supplies used in disaster management. To prepare for natural disasters, we developed a stochastic optimization approach to select the storage location of medical supplies and determine their inventory levels and to allocate each type of medical supply. Our model also captures disaster elaborations and possible effects of disasters by using a new classification for major earthquake scenarios. We present a case study for our model for the preparedness phase. As a case study, we applied our model to earthquake planning in Adana, Turkey. The experimental evaluations showed that the model is robust and effective. (Disaster Med Public Health Preparedness. 2017;page 1 of 9).

  20. Helping concerned family members of individuals with substance use and concurrent disorders: An evaluation of a family member-oriented treatment program.

    Science.gov (United States)

    Denomme, William James; Benhanoh, Orry

    2017-08-01

    There is a growing body of research demonstrating that families of individuals with substance use and concurrent disorders (SUCD) experience a wide range of biopsychosocial problems that significantly impedes their quality of life and health. However, there has been a relative lack of treatment programs primarily focused on improving the well-being and quality of life of these family members. The current study assessed the efficacy of such a program at reducing stress, increasing perceived social support from family and friends, and increasing general, dyadic, and self-rated family functioning within these concerned family members. A sample of 125 family members of individuals with SUCDs was recruited, of which 97 participated in the treatment program and 28 were used as the comparison group. Results indicated that the treatment program significantly reduced stress, increased perceived social support from family and friends, and increased general, dyadic and self-rated family functioning. A perceived personal benefits questionnaire demonstrated that participants had a better understanding of SUCDs, better coping capabilities in regard to emotional difficulties, adopted stronger coping methods, participated in more leisure activities, and improved their relationship with the individual with a SUCD. The results of the current study further demonstrate the need to implement more of these family-member oriented psycho-educational treatment programs. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. NASA Broad Specification Fuels Combustion Technology program - Pratt and Whitney Aircraft Phase I results and status

    Science.gov (United States)

    Lohmann, R. P.; Fear, J. S.

    1982-01-01

    In connection with increases in the cost of fuels and the reduced availability of high quality petroleum crude, a modification of fuel specifications has been considered to allow acceptance of poorer quality fuels. To obtain the information upon which a selection of appropriate fuels for aircraft can be based, the Broad Specification Fuels Combustion Technology program was formulated by NASA. A description is presented of program-related investigations conducted by an American aerospace company. The specific objective of Phase I of this program has been to evaluate the impact of the use of broadened properties fuels on combustor design through comprehensive combustor rig testing. Attention is given to combustor concepts, experimental evaluation, results obtained with single stage combustors, the stage combustor concept, and the capability of a variable geometry combustor.

  2. A C++-embedded Domain-Specific Language for programming the MORA soft processor array

    OpenAIRE

    Vanderbauwhede, W.; Margala, M.; Chalamalasetti, S.R.; Purohit, S.

    2010-01-01

    MORA is a novel platform for high-level FPGA programming of streaming vector and matrix operations, aimed at multimedia applications. It consists of soft array of pipelined low-complexity SIMD processors-in-memory (PIM). We present a Domain-Specific Language (DSL) for high-level programming of the MORA soft processor array. The DSL is embedded in C++, providing designers with a familiar language framework and the ability to compile designs using a standard compiler for functional testing befo...

  3. Exploring Product-Specific Attributes of a Community Cardiac Rehabilitation Program in an Asian Urban City.

    Science.gov (United States)

    Kwan, Yu Heng; Yap, Angela Frances; Tay, Hung Yong; Lim, Cindy; Chan, Sui Yung; Fong, Warren

    2017-05-01

    Cardiac rehabilitation (CR) has been proven to improve long-term outcomes for patients. Despite its benefits, its uptake throughout the world is poor. Factors affecting the motivation and barriers impeding an individual from participating in a CR program have been extensively studied. Nevertheless, knowledge of product-specific factors in affecting participation is lacking. To find out cultural-specific product attributes that are important to those contemplating participation in a community-based CR program using Consolidated criteria for Reporting Qualitative research (COREQ) as an anchor. Participants were recruited from attendees of the CR program at the Singapore Heart Foundation. A literature review was done to identify product-specific attributes that affected participation in CR programs. An interview guide was developed on the basis of the list of product attributes. The analysis was done by two independent analysts using NVivo version 11 (QSR International, Melbourne, Australia) via an inductive approach. Data analysis was carried out with recruitment and interviews ongoing until thematic saturation was reached. In total, 13 male and 9 female participants (16 Chinese, 4 Indian, 1 Malay, and 1 Eurasian) aged between 47 and 89 years were interviewed. A total of 8 categories (System, Infrastructure, Environment, Monitoring, Activity, Program, Staff, and Companionship) with 30 subcategories were identified. New themes that have not been explored by previous studies were discovered under five different categories: System, Infrastructure, Environment, Program, and Companionship. This study allows a better understanding of product-specific factors affecting participation in CR programs and serves as a springboard for further research to improve participation in community-based CR programs. Copyright © 2017. Published by Elsevier Inc.

  4. SLS-SPEC-159 Cross-Program Design Specification for Natural Environments (DSNE) Revision D

    Science.gov (United States)

    Roberts, Barry C.

    2015-01-01

    This document is derived from the former National Aeronautics and Space Administration (NASA) Constellation Program (CxP) document CxP 70023, titled "The Design Specification for Natural Environments (DSNE), Revision C." The original document has been modified to represent updated Design Reference Missions (DRMs) for the NASA Exploration Systems Development (ESD) Programs. The DSNE completes environment-related specifications for architecture, system-level, and lower-tier documents by specifying the ranges of environmental conditions that must be accounted for by NASA ESD Programs. To assure clarity and consistency, and to prevent requirements documents from becoming cluttered with extensive amounts of technical material, natural environment specifications have been compiled into this document. The intent is to keep a unified specification for natural environments that each Program calls out for appropriate application. This document defines the natural environments parameter limits (maximum and minimum values, energy spectra, or precise model inputs, assumptions, model options, etc.), for all ESD Programs. These environments are developed by the NASA Marshall Space Flight Center (MSFC) Natural Environments Branch (MSFC organization code: EV44). Many of the parameter limits are based on experience with previous programs, such as the Space Shuttle Program. The parameter limits contain no margin and are meant to be evaluated individually to ensure they are reasonable (i.e., do not apply unrealistic extreme-on-extreme conditions). The natural environments specifications in this document should be accounted for by robust design of the flight vehicle and support systems. However, it is understood that in some cases the Programs will find it more effective to account for portions of the environment ranges by operational mitigation or acceptance of risk in accordance with an appropriate program risk management plan and/or hazard analysis process. The DSNE is not intended

  5. Energy star product specification development framework: Using data and analysis to make program decisions

    Energy Technology Data Exchange (ETDEWEB)

    McWhinney, Marla; Fanara, Andrew; Clark, Robin; Hershberg, Craig; Schmeltz, Rachel; Roberson, Judy

    2003-09-12

    The Product Development Team (PD) in the US Environmental Protection Agency's ENERGY STAR Labeling Program fuels the long-term market transformation process by delivering new specifications. PD's goal is to expand the reach and visibility of ENERGY STAR as well as the market for new energy-efficient products. Since 2000, PD has launched nine new ENERGY STAR specifications and continues to evaluate new program opportunities. To evaluate the ENERGY STAR carbon savings potential for a diverse group of products, PD prepared a framework for developing new and updating existing specifications that rationalizes new product opportunities and draws upon the expertise and resources of other stakeholders, including manufacturers, utilities, environmental groups and other government agencies. By systematically reviewing the potential of proposed product areas, PD makes informed decisions as to whether or not to proceed with developing a specification. In support of this strategy, PD ensures that new product specifications are consistent with the ENERGY STAR guidelines and that these guidelines are effectively communicated to stakeholders during the product development process. To date, the framework has been successful in providing consistent guidance on collecting the necessary information on which to base sound program decisions. Through the application of this framework, PD increasingly recognizes that each industry has unique market and product characteristics that can require reconciliation with the ENERGY STAR guidelines. The new framework allows PD to identify where reconciliation is needed to justify program decisions.

  6. Program-specific cost-effectiveness analysis: breast cancer screening policies for a safety-net program.

    Science.gov (United States)

    Melnikow, Joy; Tancredi, Daniel J; Yang, Zhuo; Ritley, Dominique; Jiang, Yun; Slee, Christina; Popova, Svetlana; Rylett, Phillip; Knutson, Kirsten; Smalley, Sherie

    2013-01-01

    Every Woman Counts (EWC), a California breast cancer screening program, faced challenging budget cutbacks and policy choices. A microsimulation model evaluated costs, outcomes, and cost-effectiveness of EWC program mammography policy options on coverage for digital mammography (which has a higher cost than film mammography but recent legislation allowed reimbursement at the lower film rate); screening eligibility age; and screening frequency. Model inputs were based on analyses of program claims data linked to California Cancer Registry data, Surveillance, Epidemiology, and End Results data, and the Medi-Cal literature. Outcomes included number of procedures, cancers, cancer deaths, costs, and incremental cost per life-year. Projected model outcomes matched program data closely. With restrictions on the number of clients screened, strategies starting screening at age 40 years were dominated (not cost-effective). This finding was highly robust in sensitivity analyses. Compared with no screening, biennial film mammography for women aged 50 to 64 years was projected to reduce 15-year breast cancer mortality by nearly 7.8% at $18,999 per additional life-year, annual film mammography was $106,428 per additional life-year, and digital mammography $180,333 per additional life-year. This more effective, more expensive strategy was projected to reduce breast cancer mortality by 8.6%. Under equal mammography reimbursement, biennial digital mammography beginning at age 50 years was projected to decrease 15-year breast cancer mortality by 8.6% at an incremental cost per additional life-year of $17,050. For the EWC program, biennial screening mammography starting at age 50 years was the most cost-effective strategy. The impact of digital mammography on life expectancy was small. Program-specific cost-effectiveness analysis can be completed in a policy-relevant time frame to assist policymakers faced with difficult program choices. Copyright © 2013, International Society for

  7. 75 FR 57973 - National Protection and Programs Directorate; Sector-Specific Agency Executive Management Office...

    Science.gov (United States)

    2010-09-23

    ... SECURITY National Protection and Programs Directorate; Sector-Specific Agency Executive Management Office... partners, both public and private. An SSA is responsible for leading a unified public-private sector effort... resiliency of the Nation by leading the unified public-private sector effort to ensure its assigned CIKR are...

  8. Separation of Concerns

    DEFF Research Database (Denmark)

    Ernst, Erik

    2003-01-01

    Separation of concerns is a crucial concept in discussions about software engineering consequences of programming language design decisions, especially in AOSD. This paper proposes a way to formalize this concept, and argues that the given formalization is useful even if it is used primarily...

  9. 25 CFR 39.137 - May schools operate a language development program without a specific appropriation from Congress?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false May schools operate a language development program... Formula Language Development Programs § 39.137 May schools operate a language development program without a specific appropriation from Congress? Yes, a school may operate a language development program...

  10. Gene-regulatory interactions in embryonic stem cells represent cell-type specific gene regulatory programs.

    Science.gov (United States)

    Ha, Misook; Hong, Soondo

    2017-10-13

    Pluripotency, the ability of embryonic stem cells to differentiate into specialized cell types, is determined by ESC-specific gene regulators such as transcription factors and chromatin modification factors. It is not well understood how ESCs are poised for differentiation, however, and methods are needed for prognosis of the molecular changes in the differentiation of ESCs into specific organs. We describe a new approach to infer cell-type specific gene regulatory programs based on gene regulatory interactions in ESCs. Our method infers the molecular logic of gene regulatory mechanisms by mapping the position-specific combinatory patterns of numerous regulators in ESCs into cell-type specific gene regulations. We validate the proposed approach by recapitulating the RNA-seq and microarray data of neuronal progenitor cells, adult liver cells, and ESCs from the integrated patterns of diverse gene regulators in ESCs. We find that the collective functions of diverse gene regulators in ESCs represent distinct gene regulatory programs in specialized cell types. Our new approach expands our understanding of the differential gene regulatory information in developments encoded in regulatory networks of ESCs. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  11. Program specific admission testing and dropout for sports science students: a prospective cohort study

    DEFF Research Database (Denmark)

    O'Neill, Lotte; Christensen, Mette Krogh; Vonsild, Maria Cecilie

    2014-01-01

    Recent research in medical education suggests that program specific admission testing could have a protective effect against early dropout. Little is known about the effect of program specific admission testing on dropout in other areas of higher education. The aim of this paper was to examine if......-based admission. This result may fit with elements of previous dropout theory, student-environment fit theory and perhaps also with self-efficacy theory....... was multivariate logistic regression and predictors examined were: admission group (grade-based or admission tested) as well as educational and socio-demographic variables. The outcome was dropout within 2 years of study start. Admission testing offered superior protection against dropout compared to grade...

  12. Human-Specific Bacterial Pore-Forming Toxins Induce Programmed Necrosis in Erythrocytes

    Science.gov (United States)

    LaRocca, Timothy J.; Stivison, Elizabeth A.; Hod, Eldad A.; Spitalnik, Steven L.; Cowan, Peter J.; Randis, Tara M.

    2014-01-01

    ABSTRACT A subgroup of the cholesterol-dependent cytolysin (CDC) family of pore-forming toxins (PFTs) has an unusually narrow host range due to a requirement for binding to human CD59 (hCD59), a glycosylphosphatidylinositol (GPI)-linked complement regulatory molecule. hCD59-specific CDCs are produced by several organisms that inhabit human mucosal surfaces and can act as pathogens, including Gardnerella vaginalis and Streptococcus intermedius. The consequences and potential selective advantages of such PFT host limitation have remained unknown. Here, we demonstrate that, in addition to species restriction, PFT ligation of hCD59 triggers a previously unrecognized pathway for programmed necrosis in primary erythrocytes (red blood cells [RBCs]) from humans and transgenic mice expressing hCD59. Because they lack nuclei and mitochondria, RBCs have typically been thought to possess limited capacity to undergo programmed cell death. RBC programmed necrosis shares key molecular factors with nucleated cell necroptosis, including dependence on Fas/FasL signaling and RIP1 phosphorylation, necrosome assembly, and restriction by caspase-8. Death due to programmed necrosis in RBCs is executed by acid sphingomyelinase-dependent ceramide formation, NADPH oxidase- and iron-dependent reactive oxygen species formation, and glycolytic formation of advanced glycation end products. Bacterial PFTs that are hCD59 independent do not induce RBC programmed necrosis. RBC programmed necrosis is biochemically distinct from eryptosis, the only other known programmed cell death pathway in mature RBCs. Importantly, RBC programmed necrosis enhances the growth of PFT-producing pathogens during exposure to primary RBCs, consistent with a role for such signaling in microbial growth and pathogenesis. PMID:25161188

  13. Spermatogenesis-specific features of the meiotic program in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Diane C Shakes

    2009-08-01

    Full Text Available In most sexually reproducing organisms, the fundamental process of meiosis is implemented concurrently with two differentiation programs that occur at different rates and generate distinct cell types, sperm and oocytes. However, little is known about how the meiotic program is influenced by such contrasting developmental programs. Here we present a detailed timeline of late meiotic prophase during spermatogenesis in Caenorhabditis elegans using cytological and molecular landmarks to interrelate changes in chromosome dynamics with germ cell cellularization, spindle formation, and cell cycle transitions. This analysis expands our understanding C. elegans spermatogenesis, as it identifies multiple spermatogenesis-specific features of the meiotic program and provides a framework for comparative studies. Post-pachytene chromatin of spermatocytes is distinct from that of oocytes in both composition and morphology. Strikingly, C. elegans spermatogenesis includes a previously undescribed karyosome stage, a common but poorly understood feature of meiosis in many organisms. We find that karyosome formation, in which chromosomes form a constricted mass within an intact nuclear envelope, follows desynapsis, involves a global down-regulation of transcription, and may support the sequential activation of multiple kinases that prepare spermatocytes for meiotic divisions. In spermatocytes, the presence of centrioles alters both the relative timing of meiotic spindle assembly and its ultimate structure. These microtubule differences are accompanied by differences in kinetochores, which connect microtubules to chromosomes. The sperm-specific features of meiosis revealed here illuminate how the underlying molecular machinery required for meiosis is differentially regulated in each sex.

  14. Towards Interactive Visual Exploration of Parallel Programs using a Domain-Specific Language

    KAUST Repository

    Klein, Tobias

    2016-04-19

    The use of GPUs and the massively parallel computing paradigm have become wide-spread. We describe a framework for the interactive visualization and visual analysis of the run-time behavior of massively parallel programs, especially OpenCL kernels. This facilitates understanding a program\\'s function and structure, finding the causes of possible slowdowns, locating program bugs, and interactively exploring and visually comparing different code variants in order to improve performance and correctness. Our approach enables very specific, user-centered analysis, both in terms of the recording of the run-time behavior and the visualization itself. Instead of having to manually write instrumented code to record data, simple code annotations tell the source-to-source compiler which code instrumentation to generate automatically. The visualization part of our framework then enables the interactive analysis of kernel run-time behavior in a way that can be very specific to a particular problem or optimization goal, such as analyzing the causes of memory bank conflicts or understanding an entire parallel algorithm.

  15. Protect your heart: a culture-specific multimedia cardiovascular health education program.

    Science.gov (United States)

    Shah, Amy; Clayman, Marla L; Glass, Sara; Kandula, Namratha R

    2015-04-01

    South Asians, the second fastest growing racial/ethnic minority in the United States, have high rates of coronary heart disease. Few coronary heart disease prevention efforts target this population. The authors developed and tested a culture-specific, multimedia coronary heart disease prevention education program in English and Hindi for South Asians. Participants were recruited from community organizations in Chicago, Illinois, between June and October of 2011. Bilingual interviewers used questionnaires to assess participants' knowledge and perceptions before and after the patient education program. The change from pretest score to posttest score was calculated using a paired t test. Linear regression was used to determine the association between posttest scores and education and language. Participants' (N = 112) average age was 41 years, 67% had more than a high school education, and 50% spoke Hindi. Participants' mean pretest score was 15 (SD = 4). After the patient education program, posttest scores increased significantly among all participants (posttest score = 24, SD = 4), including those with limited English proficiency. Lower education was associated with a lower posttest score (β = -2.2, 95% CI [-0.68, -3.83]) in adjusted regression. A culture-specific, multimedia patient education program significantly improved knowledge and perceptions about coronary heart disease prevention among South Asian immigrants. Culturally salient multimedia education may be an effective and engaging way to deliver health information to diverse patient populations.

  16. CASL - The CoFI Algebraic Specification Language (Tentative Design, version 0.95) - Language Summary, with annotations concerning the semantics of constructs

    DEFF Research Database (Denmark)

    Haxthausen, Anne

    1997-01-01

    This is version 0.95 of the official summary of the Tentative Design of CASL, the CoFI Algebraic Specification Language, annotated by the CoFI Semantics Task Group with suggestions for the semantics of constructs.......This is version 0.95 of the official summary of the Tentative Design of CASL, the CoFI Algebraic Specification Language, annotated by the CoFI Semantics Task Group with suggestions for the semantics of constructs....

  17. THE EFFECTIVENESS OF SPORTS SPECIFIC BALANCE TRAINING PROGRAM IN REDUCING RISK OF ANKLE SPRAIN IN BASKETBALL

    Directory of Open Access Journals (Sweden)

    Ai Choo LEE

    2016-12-01

    Full Text Available Background: To investigate the effectiveness of four weeks sports specific balance training program to improve balance, thus reducing the risk of ankle sprain among Sultan Idris Education University basketball players. Method: There were 20 males basketball players (aged 19-24 years volunteered in this study. After screening process, there were14 male players met the inclusion criteria. They were randomized into two groups i.e experimental group (EG: n=7 and control group (CG: n=7. The EG undergone the four weeks sports specific balance training program three times per week while the CG followed their normal standard basketball training program. Balance Error Scoring System (BESS was used to assess static balance while Star Excursion Balance Test (SEBT is utilized to examine the dynamic balance. Pretest and posttest of balance measures were recorded using BESS and SEBT for both EG and CG. The data were analyzed using independent sample t-test (p=0.05. Results: The study findings indicated that there were significant differences between EG and CG for the static balance on firm surface (t=-4.642, p=0.001 and on foam surface (t=-8.590, P=0.000 as well as dynamic balance on left leg stance (t=2.350, P=0.037 and on right leg stance (t=3.145, P=0.008. Conclusion: The study findings indicated that the four weeks sports specific balance training program could improve balance ability in male basketball players, thus may reducing the risk of ankle sprain.

  18. Automated size-specific CT dose monitoring program: assessing variability in CT dose.

    Science.gov (United States)

    Christianson, Olav; Li, Xiang; Frush, Donald; Samei, Ehsan

    2012-11-01

    The potential health risks associated with low levels of ionizing radiation have created a movement in the radiology community to optimize computed tomography (CT) imaging protocols to use the lowest radiation dose possible without compromising the diagnostic usefulness of the images. Despite efforts to use appropriate and consistent radiation doses, studies suggest that a great deal of variability in radiation dose exists both within and between institutions for CT imaging. In this context, the authors have developed an automated size-specific radiation dose monitoring program for CT and used this program to assess variability in size-adjusted effective dose from CT imaging. The authors radiation dose monitoring program operates on an independent health insurance portability and accountability act compliant dosimetry server. Digital imaging and communication in medicine routing software is used to isolate dose report screen captures and scout images for all incoming CT studies. Effective dose conversion factors (k-factors) are determined based on the protocol and optical character recognition is used to extract the CT dose index and dose-length product. The patient's thickness is obtained by applying an adaptive thresholding algorithm to the scout images and is used to calculate the size-adjusted effective dose (ED(adj)). The radiation dose monitoring program was used to collect data on 6351 CT studies from three scanner models (GE Lightspeed Pro 16, GE Lightspeed VCT, and GE Definition CT750 HD) and two institutions over a one-month period and to analyze the variability in ED(adj) between scanner models and across institutions. No significant difference was found between computer measurements of patient thickness and observer measurements (p = 0.17), and the average difference between the two methods was less than 4%. Applying the size correction resulted in ED(adj) that differed by up to 44% from effective dose estimates that were not adjusted by patient size

  19. DCD – a novel plant specific domain in proteins involved in development and programmed cell death

    Directory of Open Access Journals (Sweden)

    Doerks Tobias

    2005-07-01

    Full Text Available Abstract Background Recognition of microbial pathogens by plants triggers the hypersensitive reaction, a common form of programmed cell death in plants. These dying cells generate signals that activate the plant immune system and alarm the neighboring cells as well as the whole plant to activate defense responses to limit the spread of the pathogen. The molecular mechanisms behind the hypersensitive reaction are largely unknown except for the recognition process of pathogens. We delineate the NRP-gene in soybean, which is specifically induced during this programmed cell death and contains a novel protein domain, which is commonly found in different plant proteins. Results The sequence analysis of the protein, encoded by the NRP-gene from soybean, led to the identification of a novel domain, which we named DCD, because it is found in plant proteins involved in development and cell death. The domain is shared by several proteins in the Arabidopsis and the rice genomes, which otherwise show a different protein architecture. Biological studies indicate a role of these proteins in phytohormone response, embryo development and programmed cell by pathogens or ozone. Conclusion It is tempting to speculate, that the DCD domain mediates signaling in plant development and programmed cell death and could thus be used to identify interacting proteins to gain further molecular insights into these processes.

  20. An algorithm and program for finding sequence specific oligo-nucleotide probes for species identification

    Directory of Open Access Journals (Sweden)

    Tautz Diethard

    2002-03-01

    Full Text Available Abstract Background The identification of species or species groups with specific oligo-nucleotides as molecular signatures is becoming increasingly popular for bacterial samples. However, it shows also great promise for other small organisms that are taxonomically difficult to tract. Results We have devised here an algorithm that aims to find the optimal probes for any given set of sequences. The program requires only a crude alignment of these sequences as input and is optimized for performance to deal also with very large datasets. The algorithm is designed such that the position of mismatches in the probes influences the selection and makes provision of single nucleotide outloops. Program implementations are available for Linux and Windows.

  1. Is the Program-Specific Paragraph Responsible for Declining Application Numbers? A Commentary.

    Science.gov (United States)

    Kramer, Scott

    2018-02-01

    An alarming trend of declining applications to otolaryngology-head and neck surgery has surfaced over the past 3 years. There are many possible explanations for this decline, and a recent publication has implicated "impossible" qualifications as the reason for this decline. While these qualifications may deter a significant number of potential applicants, they have not changed significantly in the past 5 years and do not seem to explain a sudden decline. This commentary argues that the program-specific paragraph, which was introduced in 2015, may be at least in part responsible.

  2. Post-deepwater horizon blowout seafood consumption patterns and community-specific levels of concern for selected chemicals among children in Mobile County, Alabama.

    Science.gov (United States)

    Sathiakumar, Nalini; Tipre, Meghan; Turner-Henson, Anne; Chen, Ligong; Leader, Mark; Gohlke, Julia

    2017-01-01

    The goal of the study was to characterize risk pertaining to seafood consumption patterns following the Deepwater Horizon oil spill, among school children (K to 4th grade) residing in close proximity to the Gulf of Mexico in Mobile County, Alabama. Responses on seafood consumption pattern including the type of seafood and intake rate during the pre and post oil spill periods, from parents of 55 school children from three schools located <20mile radius from the Gulf of Mexico shoreline (coastal group) were compared with those from parents of 55 children from three schools located ≥20miles away from the shoreline (inland group). We also estimated levels of concern (LOCs) in seafood for selected chemicals found in crude oil including heavy metals, and polycyclic aromatic hydrocarbons (PAH), and dioctyl sodium sulfosuccinate (DOSS), the primary compound in dispersants. The coastal group ate more seafood consisting primarily of crustaceans (62% vs. 42%, p=0.04) and fin fish (78% vs. 58%, p=0.02) from the Gulf of Mexico compared to the inland group, while the inland group ate more fin fish not found in the Gulf of Mexico (62% vs. 33%, p<0.01). In the post-oil spill time period, both groups substantially reduced their consumption of sea food. On average, the coastal group ate ≥2 seafood meals per week, while the inland group ate ≤1 meal per week; these frequency patterns persisted in the post oil-spill period. Comparison of the estimated LOCs with contaminant levels detected in the seafood tested by the Food and Drug Administration and National Oceanic and Atmospheric Administration, post-oil spill, found that the levels of PAHs, arsenic, and DOSS in seafood were 1-2 orders of magnitude below the LOCs calculated in our study. Levels of methyl mercury (MeHg) in the seafood tested pre- and post- oil spill were higher than the estimated LOCs suggesting presence of higher levels of MeHg in seafood independent of the oil spill. In sum, the study found higher than average

  3. [Factors and prosesses associated with weight loss in male workers in a specific health guidance program. A qualitative analysis of in-depth interviews].

    Science.gov (United States)

    Hayashi, Fumi; Akamatsu, Rie; Ebina, Ryoko; Nishimura, Setsuko; Okuyama, Megumi; Matsuoka, Yukiyo; Nakamura, Masakazu; Sakane, Naoki; Adachi, Yoshiko; Takemi, Yukari

    2012-03-01

    A qualitative analysis was conducted to identify factors important for weight loss through a specific health guidance program and to understand the processes that were crucial in achieving success. Twenty-six male workers aged 41-59 years from five corporate health insurance societies in four prefectures who had lost > or = 4% weight by attending the six-month specific health guidance program were invited to participate in the in-depth interviews. Data were collected between October and December 2009. We audio taped the 30-minute interviews and performed qualitative analysis on the transcripts using a grounded theory. The discussion by the expert panel strengthened the validity of the analysis. The mean age was 49.9 +/- 5.6 years, and the average weight loss was 6.8 +/- 2.5%. All subjects were somewhat concerned about their health status and body shape before the first appointment, but two major prosesses, "critical feeling" and "sense of obligation," were identified after the first appointment. We also identified innovative efforts in all subjects during the process. Those who reported a "sense of obligation" at the beginning and those who had a negative perception during the program were found to have higher risks of weight rebound after the program was over. We considered personality, values, attitudes toward the program, and support from both family and workplace as the intervening conditions for behavior modification. Since everyone aged 40-74 years with a certain risk of metabolic syndromes is obligated by law to participate in the specific health guidance program, weight loss is challenging for those who are not motivated enough to change their behaviors. Therefore, the initial assessment of one's motivations, followed by interventions taken in consideration of one's lifestyle and social background, are crucial for the success of a weight loss program, as is the use of a client-centered approach.

  4. Flood Catastrophe Model for Designing Optimal Flood Insurance Program: Estimating Location-Specific Premiums in the Netherlands

    NARCIS (Netherlands)

    Ermolieva, T.; Filatova, Tatiana; Ermoliev, Y.; Obersteiner, M.; de Bruijn, K.M.; Jeuken, A.

    2017-01-01

    As flood risks grow worldwide, a well-designed insurance program engaging various stakeholders becomes a vital instrument in flood risk management. The main challenge concerns the applicability of standard approaches for calculating insurance premiums of rare catastrophic losses. This article

  5. Test methods concerning specifications for fly ash as a constituent of concrete. Metodos de ensayo, relativos a las especificaciones, aplicados a la cenizas volontes como componentes en el hormigon

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez de Rojas, M.I.; Luxan, M.P.; Frias, M.; Garcia, N. (Inst. cienc. coustruc. ' Eduardo Torroja' , Madrid (Spain))

    1991-01-01

    Flyash is used in the construction industry as an additive because of the favourable properties it imparts to concrete manufactured with it and because it reduces costs. The present article makes a critical analysis of established specifications describing test methods used and comparing the effectiveness of these methods with methods found in other standards studied. There was a notable similarity between the test methods and specifications used in international standards. This emphasises the concern of different countries to reach an agreement which would result in a common international standard and would make it possible to establish a 'single language' with regard to product quality. 7 refs., 5 figs.

  6. Abnormal lactate levels in patients with polymyositis and dermatomyositis: the benefits of a specific rehabilitative program.

    Science.gov (United States)

    Bertolucci, F; Neri, R; Dalise, S; Venturi, M; Rossi, B; Chisari, C

    2014-04-01

    Polymyositis (PM) and Dermatomyositis (DM) are chronic, inflammatory and autoimmune skeletal muscle disorders characterized by reduced muscle strength, fatigue and myalgia. While inflammation causes muscle damage in the early phase, metabolic alterations such as an impairment of oxidative metabolism seem to be responsible for the disability in the chronic phase of the disease. To assess muscle oxidative efficiency and to test the effect of aerobic training in a group of PM/DM patients. A case-control study and a within-group comparison. SETTING. Outpatients of the Unit of Neurorehabilitation of the University Hospital of Pisa. 20 patients with myositis (15 PM and 5 DM) and 15 healthy subjects as a control group. The test consisted of an incremental, sub-maximal aerobic exercise on a treadmill; haematic lactate was assessed at rest and after 1', 5', 10' and 30' minutes from the end of the exercise. A within-group comparison was conducted on four of the PM patients (P group). They were subjected to six weeks aerobic training. Lactate curve and functional tests were assessed before and after the treatment. A precocious fatigability and significantly higher values of lactate at rest and after the exercise were observed in patients. In the P group mean lactate levels were significantly decreased after the treatment and an improvement of muscle performance was observed. Abnormal blood lactate levels suggested an impaired muscle oxidative efficiency in PM/DM patients. A specific aerobic training program reduced lactate levels and relieved fatigue symptoms in a within-group of four of the PM patients. Such a specific aerobic training program could be introduced in everyday practice for the rehabilitative treatment of PM/DM patients.

  7. Sex-specific programming of offspring emotionality after stress early in pregnancy.

    Science.gov (United States)

    Mueller, Bridget R; Bale, Tracy L

    2008-09-03

    Prenatal stress is associated with an increased vulnerability to neurodevelopmental disorders, including autism and schizophrenia. To determine the critical time window when fetal antecedents may induce a disease predisposition, we examined behavioral responses in offspring exposed to stress during early, mid, and late gestation. We found that male offspring exposed to stress early in gestation displayed maladaptive behavioral stress responsivity, anhedonia, and an increased sensitivity to selective serotonin reuptake inhibitor treatment. Long-term alterations in central corticotropin-releasing factor (CRF) and glucocorticoid receptor (GR) expression, as well as increased hypothalamic-pituitary-adrenal (HPA) axis responsivity, were present in these mice and likely contributed to an elevated stress sensitivity. Changes in CRF and GR gene methylation correlated with altered gene expression, providing important evidence of epigenetic programming during early prenatal stress. In addition, we found the core mechanism underlying male vulnerability may involve sex-specific placenta responsivity, where stress early in pregnancy significantly increased expression of PPARalpha (peroxisome proliferator-activated receptor alpha), IGFBP-1 (insulin-like growth factor binding protein 1), HIF3alpha (hypoxia-inducible factor 3a), and GLUT4 (glucose transporter 4) in male placentas but not females. Examination of placental epigenetic machinery revealed basal sex differences, providing further evidence that sex-specific programming begins very early in pregnancy, and may contribute to the timing and vulnerability of the developing fetus to maternal perturbations. Overall, these results indicate that stress experience early in pregnancy may contribute to male neurodevelopmental disorders through impacts on placental function and fetal development.

  8. Outcomes of a headache-specific cross-sectional multidisciplinary treatment program.

    Science.gov (United States)

    Wallasch, Thomas-Martin; Angeli, Andreas; Kropp, Peter

    2012-01-01

    Chronic headache is a disabling disorder that is frequently poorly managed in general clinical practice. To investigate primary (headache frequency in days/month) and secondary (headache-related disability, lost work/school time, anxiety and depression, amount and intake frequency of acute medication) 12-month outcomes of a headache-specific cross-sectional outpatient and inpatient multidisciplinary treatment program using a dedicated computer system for data collection and corresponding between integrated care team in a tertiary headache center and practicing headache specialists. A need for integrated headache care using comprehensive and standardized assessment for diagnosis of headache, psychiatric comorbidity, and burden of disease exists. There are little published data on long-term efficacy of multidisciplinary treatment programs for chronic headache. A prospective, observational, 12-month, follow-up study. Prospectively recruited consecutive patients with frequent difficult-to-treat headaches (n = 201; 63 migraine, 11 tension-type headache, 59 combined migraine/tension-type headache, and 68 medication overuse headache) were enrolled. Outcome measures included prospective headache diaries, a medication survey, Migraine Disability Assessment, 12-item short form health survey, and the Hospital Anxiety and Depression Scale. The primary outcome of a reduction of ≥50% of headache frequency (days/month) was observed in 62.7%. Mean headache frequency decreased from 14.4 ± 8.2 to 7.6 ± 8.3 days/month, P work/school, and familiarity with progressive muscle relaxation therapy at baseline. The present analysis provided support for a cross-sectional multidisciplinary integrated headache-care program. © 2012 American Headache Society.

  9. Ski and snowboard school programs: Injury surveillance and risk factors for grade-specific injury.

    Science.gov (United States)

    Sran, R; Djerboua, M; Romanow, N; Mitra, T; Russell, K; White, K; Goulet, C; Emery, C; Hagel, B

    2017-12-19

    The objective of our study was to evaluate incidence rates and profile of school program ski and snowboard-related injuries by school grade group using a historical cohort design. Injuries were identified via Accident Report Forms completed by ski patrollers. Severe injury was defined as those with ambulance evacuation or recommending patient transport to hospital. Poisson regression analysis was used to examine the school grade group-specific injury rates adjusting for risk factors (sex, activity, ability, and socioeconomic status) and accounting for the effect of clustering by school. Forty of 107 (37%) injuries reported were severe. Adolescents (grades 7-12) had higher crude injury rates (91 of 10 000 student-days) than children (grades 1-3: 25 of 10 000 student-days; grades 4-6: 65 of 10 000 student-days). Those in grades 1-3 had no severe injuries. Although the rate of injury was lower in grades 1-3, there were no statistically significant grade group differences in adjusted analyses. Snowboarders had a higher rate of injury compared with skiers, while higher ability level was protective. Participants in grades 1-3 had the lowest crude and adjusted injury rates. Students in grades 7-12 had the highest rate of overall and severe injuries. These results will inform evidence-based guidelines for school ski/snowboard program participation by school-aged children. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. THE GAP BETWEEN LEARNING NEEDS AND ITS’ IMPLEMENTATION IN ENGLISH FOR HOSPITALITY SPECIFIC PURPOSES PROGRAM

    Directory of Open Access Journals (Sweden)

    Dian Kardijan

    2017-12-01

    Full Text Available This study is to reveal the gap between the English language communicative competence required by students of the hospitality department and English learning program provided at state of Vocational High School 1 Tasikmalaya, Indonesia, drawing through qualitative evaluation approach, including semi-structured interviews and observations. It explores how learning needs is implemented in teaching-learning process and the respondents’ description, what they saw and what they felt. Findings show inconsistency between learning needs in enrichment students’ English communicative competence and teaching-learning process. This prompts a re-instructional design of English learning for hospitality specific purposes program at this department currently. It provides to support of graduating required at hospitality industry workplace. Lead of recommendations, in terms of both the instructional design including materials development, teaching method usage and the professional development of ESP teachers, to address an understanding of the gap identified, so that students will enable to communicate more effectively with the English, in such contexts graduates can hire at the hospitality industry workplace.

  11. Addressing the Health Concerns of VA Women with Sexual Trauma

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-14-1-0368 TITLE: Addressing the Health Concerns of VA Women with Sexual Trauma PRINCIPAL INVESTIGATOR: Caron Zlotnick, PhD...develop and assess a computer-delivered intervention (Safety and Health Experiences Program; SHE) that will provide a screening and brief behavior...intervention for women veterans with any lifetime ST. More specifically, the intervention, SHE, will address interrelated health concerns for women

  12. Culture-specific programs for children and adults from minority groups who have asthma.

    Science.gov (United States)

    McCallum, Gabrielle B; Morris, Peter S; Brown, Ngiare; Chang, Anne B

    2017-08-22

    studies ranged from very low to low. For our primary outcome (asthma exacerbations during follow-up), the quality of evidence was low for all outcomes. In adults, use of a culture-specific programme, compared to generic programmes or usual care did not significantly reduce the number of participants from two studies with 294 participants for: exacerbations with one or more exacerbations during follow-up (odds ratio (OR) 0.80, 95% confidence interval (CI) 0.50 to 1.26), hospitalisations over 12 months (OR 0.83, 95% CI 0.31 to 2.22) and exacerbations requiring oral corticosteroids (OR 0.97, 95% CI 0.55 to 1.73). However, use of a culture-specific programme, improved asthma quality of life scores in 280 adults from two studies (mean difference (MD) 0.26, 95% CI 0.17 to 0.36) (although the MD was less then the minimal important difference for the score). In children, use of a culture-specific programme was superior to generic programmes or usual care in reducing severe asthma exacerbations requiring hospitalisation in two studies with 305 children (rate ratio 0.48, 95% CI 0.24 to 0.95), asthma control in one study with 62 children and QoL in three studies with 213 children, but not for the number of exacerbations during follow-up (OR 1.55, 95% CI 0.66 to 3.66) or the number of exacerbations (MD 0.18, 95% CI -0.25 to 0.62) among 100 children from two studies. The available evidence showed that culture-specific education programmes for adults and children from minority groups are likely effective in improving asthma-related outcomes. This review was limited by few studies and evidence of very low to low quality. Not all asthma-related outcomes improved with culture-specific programs for both adults and children. Nevertheless, while modified culture-specific education programs are usually more time intensive, the findings of this review suggest using culture-specific asthma education programmes for children and adults from minority groups. However, more robust RCTs are needed to

  13. Do Girls Profit More? Gender-Specific Effectiveness of a Life Skills Program against Alcohol Consumption in Early Adolescence

    Science.gov (United States)

    Weichold, Karina; Brambosch, Anett; Silbereisen, Rainer K.

    2012-01-01

    This study investigated the effectiveness of a life skills program with regard to alcohol consumption, life skills, knowledge, and school bonding for young adolescents. The focus was on the moderating role of gender, based on the assumption that life skills programs may address specific needs of adolescent girls better than those of boys. The…

  14. Legal and Definitional Issues Affecting the Identification and Education of Adults with Specific Learning Disabilities in Adult Education Programs

    Science.gov (United States)

    Taymans, Juliana M.

    2012-01-01

    Although the exact prevalence is not determined, a noticeable subset of individuals who enroll in adult education and training programs have either diagnosed or undiagnosed specific learning disabilities (SLD). Understanding SLD is important basic information for adult educators to inform program policies as well as determine effective…

  15. Can a Specific Neck Strengthening Program Decrease Cervical Spine Injuries in a Men's Professional Rugby Union Team? A Retrospective Analysis

    Science.gov (United States)

    Naish, Robert; Burnett, Angus; Burrows, Sally; Andrews, Warren; Appleby, Brendyn

    2013-01-01

    Cervical spine injuries in Rugby Union are a concerning issue at all levels of the game. The primary aim of this retrospective analysis conducted in a professional Rugby Union squad was to determine whether a 26-week isometric neck strengthening intervention program (13-week strengthening phase and 13-week maintenance phase) was effective in reducing the number and severity of cervical spine injuries. The secondary aim was to determine whether at week five, where the program had been the similar for all players, there was increased isometric neck strength. All 27 players who were common to both the 2007-2008 and 2008-2009 seasons were included in this analysis and data was extracted from a Sports Medicine/Sports Science database which included the squad's injury records. Primary outcome variables included; the number of cervical spine injuries and the severity of these injuries as determined by the total number of days lost from training and competition. Secondary outcome variables included isometric neck strength in flexion, extension and left and right lateral flexion. Using non-parametric statistical methods, no significant differences were evident for the total number of cervical spine injuries (n = 8 in 2007-2008, n = 6 in 2008-2009) or time loss due to these injuries (100 days in 2007-2008, 40 days in 2008-2009). However, a significant (p = 0.03) reduction in the number of match injuries was evident from 2007-2008 (n = 11) to 2008-09 (n = 2). Non-significant increases in isometric neck strength were found in all directions examined. A significant reduction in the number of match injuries was evident in this study. However, no other significant changes to primary outcome variables were achieved. Further, no significant increases in isometric neck strength were found in this well-trained group of professional athletes. Key Points While many authors have proposed that neck strengthening could be an effective strategy in preventing cervical spine injuries in

  16. RandSpg: An open-source program for generating atomistic crystal structures with specific spacegroups

    Science.gov (United States)

    Avery, Patrick; Zurek, Eva

    2017-04-01

    A new algorithm, RANDSPG, that can be used to generate trial crystal structures with specific space groups and compositions is described. The program has been designed for systems where the atoms are independent of one another, and it is therefore primarily suited towards inorganic systems. The structures that are generated adhere to user-defined constraints such as: the lattice shape and size, stoichiometry, set of space groups to be generated, and factors that influence the minimum interatomic separations. In addition, the user can optionally specify if the most general Wyckoff position is to be occupied or constrain select atoms to specific Wyckoff positions. Extensive testing indicates that the algorithm is efficient and reliable. The library is lightweight, portable, dependency-free and is published under a license recognized by the Open Source Initiative. A web interface for the algorithm is publicly accessible at http://xtalopt.openmolecules.net/randSpg/randSpg.html. RANDSPG has also been interfaced with the XTALOPT evolutionary algorithm for crystal structure prediction, and it is illustrated that the use of symmetric lattices in the first generation of randomly created individuals decreases the number of structures that need to be optimized to find the global energy minimum.

  17. Promotion Strategy Specific to Organizations Participating in “Back to School” Program

    Directory of Open Access Journals (Sweden)

    Irina SUSANU

    2009-01-01

    Full Text Available Romania’s stationery market records a growth rhythm of about 10-15percent per year. For the beginning of school year 2007-2008, organizations ofthe type forecast a growth of 25%. During the top period, stationery sales growgenerally with about 800-1000 % in comparison with a habitual period of theyear. For distributors, the season of school stationery lasts from July toSeptember, a period where it is accomplished 20-25% of the entire yearturnover. All these events unfold rapidly in a relatively short period of time, 2-3months for distributors and a month for retailers, producing a real storm in theframe of their management. In order to deal with “shopping fury” specific to thetime before the school beginning, organizations of the field are in the positionof applying a series of communication strategies. The purpose of this work is tohighlight a practical example of communication plan specific to organizationsinvolved in “back to school” program.

  18. Diabetes-specific nutrition algorithm: a transcultural program to optimize diabetes and prediabetes care.

    Science.gov (United States)

    Mechanick, Jeffrey I; Marchetti, Albert E; Apovian, Caroline; Benchimol, Alexander Koglin; Bisschop, Peter H; Bolio-Galvis, Alexis; Hegazi, Refaat A; Jenkins, David; Mendoza, Enrique; Sanz, Miguel Leon; Sheu, Wayne Huey-Herng; Tatti, Patrizio; Tsang, Man-Wo; Hamdy, Osama

    2012-04-01

    Type 2 diabetes (T2D) and prediabetes have a major global impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. To mitigate this disease burden, interventions of proven effectiveness must be used. Evidence shows that nutrition therapy improves glycemic control and reduces the risks of diabetes and its complications. Accordingly, diabetes-specific nutrition therapy should be incorporated into comprehensive patient management programs. Evidence-based recommendations for healthy lifestyles that include healthy eating can be found in clinical practice guidelines (CPGs) from professional medical organizations. To enable broad implementation of these guidelines, recommendations must be reconstructed to account for cultural differences in lifestyle, food availability, and genetic factors. To begin, published CPGs and relevant medical literature were reviewed and evidence ratings applied according to established protocols for guidelines. From this information, an algorithm for the nutritional management of people with T2D and prediabetes was created. Subsequently, algorithm nodes were populated with transcultural attributes to guide decisions. The resultant transcultural diabetes-specific nutrition algorithm (tDNA) was simplified and optimized for global implementation and validation according to current standards for CPG development and cultural adaptation. Thus, the tDNA is a tool to facilitate the delivery of nutrition therapy to patients with T2D and prediabetes in a variety of cultures and geographic locations. It is anticipated that this novel approach can reduce the burden of diabetes, improve quality of life, and save lives. The specific Southeast Asian and Asian Indian tDNA versions can be found in companion articles in this issue of Current Diabetes Reports.

  19. Existential Concerns About Death

    DEFF Research Database (Denmark)

    Moestrup, Lene; Hansen, Helle Ploug

    2014-01-01

    patients in Danish hospices. The main findings demonstrated how the patients faced the forthcoming death without being anxious of death but sorrowful about leaving life. Furthermore, patients expressed that they avoided thinking about death. However, some had reconstructed specific and positive ideas about...... psychology or Kübler-Ross’ theory about death stages. The complex concerns might be explained using Martin Heidegger’s phenomenological thinking. We aimed to illuminate dying patients´ existential concerns about the impending death through a descriptive analysis of semi-structured interviews with 17 cancer...... afterlife and made accurate decisions for practical aspects of their death. The patients wished to focus on positive aspects in their daily life at hospice. It hereby seems important to have ongoing reflections and to include different theoretical perspectives when providing existential support to dying...

  20. Existential Concerns About Death

    DEFF Research Database (Denmark)

    Moestrup, Lene; Hansen, Helle Ploug

    2015-01-01

    patients in Danish hospices. The main findings demonstrated how the patients faced the forthcoming death without being anxious of death but sorrowful about leaving life. Furthermore, patients expressed that they avoided thinking about death. However, some had reconstructed specific and positive ideas about...... psychology or Kübler-Ross’ theory about death stages. The complex concerns might be explained using Martin Heidegger’s phenomenological thinking. We aimed to illuminate dying patients´ existential concerns about the impending death through a descriptive analysis of semi-structured interviews with 17 cancer...... afterlife and made accurate decisions for practical aspects of their death. The patients wished to focus on positive aspects in their daily life at hospice. It hereby seems important to have ongoing reflections and to include different theoretical perspectives when providing existential support to dying...

  1. The Specification of Science Education Programs in the Local Public Library: Focusing on the Programs In G-city

    Directory of Open Access Journals (Sweden)

    In-Ja Ahn*

    2012-06-01

    Full Text Available The city of 'G' has been made a number of achievements with its science program as a part of public library's cultural program during the last 5 years. Recently, the national science centre has been established in the same city, the debate is now needed whether the science program in the public library have reasons to be maintained or to be reduced. The aim of this research is on the operating strategies of the science program in the public library. The research methods include case studies of operational strategies in domestic and foreign science centre, the level of satisfaction of local citizen on the science program, the vision of science program in the advancement of public library in the century. In results, the research proposes that the science program in public library should be maintained, but with locally characterised programs. In addition, the study also advised on the provision of scientific information, the strengthened search functions, and the development of user-centred services for those in science fields.

  2. Program specific admission testing and dropout for sports science students: a prospective cohort study.

    Directory of Open Access Journals (Sweden)

    Lotte Dyhrberg O'Neill

    2014-09-01

    Full Text Available Recent research in medical education suggests that program specific admission testing could have a protective effect against early dropout. Little is known about the effect of program specific admission testing on dropout in other areas of higher education. The aim of this paper was to examine if admission strategy was also independently associated with dropout for sports science students in a university setting. The study design was a prospective cohort study with a 2 year follow-up. The population was 449 sports science students admitted to a university in the years 2002-2007. The analysis used was multivariate logistic regression and the predictors examined were: admission group (grade-based or admission tested as well as educational and socio-demographic variables. The outcome was dropout within 2 years of study start. Admission testing offered superior protection against dropout compared to grade-based admission. This result may fit with elements of previous dropout theory, student-environment fit theory and perhaps also with self-efficacy theory. Nyere forskning inden for medicinsk uddannelse indikerer at uddannelsesspecifikke optagelsesprøver kan have en beskyttende effekt i forhold til tidligt studiefrafald, men for andre universitetsuddannelser end Medicin synes denne sammenhæng endnu ikke at være blevet grundigt belyst. Formålet med dette studie var derfor at undersøge, om optagelsesprøver også beskyttede mod tidligt frafald blandt idrætsstuderende på universitetet. Studiedesignet var et prospektivt kohortestudie med to års opfølgning. Populationen var 449 idrætsstuderende, som blev optaget på Syddansk Universitet i årene 2002-2007. Data blev analyseret med multivariat logistisk regression, og følgende typer af prædiktorer for frafald blev undersøgt: Optagelseskvote (kvote 1 eller kvote 2 udprøvede, andre uddannelsesrelaterede variable samt udvalgte socio-demografiske variable. Effektmålet var studiestatus (frafaldet

  3. Language-specific strategy for programming hearing aids - A double-blind randomized controlled crossover study.

    Science.gov (United States)

    Matsumoto, Nozomu; Suzuki, Nobuyoshi; Iwasaki, Satoshi; Ishikawa, Kazuha; Tsukiji, Hiroki; Higashino, Yoshie; Tabuki, Tomoko; Nakagawa, Takashi

    2017-11-17

    Voice-aligned compression (VAC) is a method used in Oticon's hearing aids to provide more comfortable hearing without sacrificing speech discrimination. The complex, non-linear compression curve for the VAC strategy is designed based on the frequency profile of certain spoken Western languages. We hypothesized that hearing aids could be further customized for Japanese-speaking users by modifying the compression curve using the frequency profile of spoken Japanese. A double-blind randomized controlled crossover study was performed to determine whether or not Oticon's modified amplification strategy (VAC-J) provides subjectively preferable hearing aids for Japanese-speaking hearing aid users compared to the same company's original amplification strategy (VAC). The participants were randomized to two groups. The VAC-first group received a pair of hearing aids programmed using the VAC strategy and wore them for three weeks, and then received a pair of hearing aids programmed using VAC-J strategy and wore them for three weeks. The VAC-J-first group underwent the same study, but they received hearing aids in the reverse sequence. A Speech, Spatial and Qualities (SSQ) questionnaire was administered before beginning to use the hearing aids, at the end of using the first pair of hearing aids, and at the end of using the second pair of hearing aids. Twenty-five participants that met the inclusion/exclusion criteria from January 1 to October 31, 2016, were randomized to two groups. Twenty-two participants completed the study. There were no statistically significant differences in the increment of SSQ scores between the participants when using the VAC- or the VAC-J-programmed hearing aids. However, participants preferred the VAC-J strategy to the VAC strategy at the end of the study, and this difference was statistically significant. Japanese-speaking hearing aid users preferred using hearing aids that were fitted with the VAC-J strategy. Our results show that the VAC strategy

  4. Wood combustion systems: status of environmental concerns

    Energy Technology Data Exchange (ETDEWEB)

    Dunwoody, J.E.; Takach, H.; Kelley, C.S.; Opalanko, R.; High, C.; Fege, A.

    1980-01-01

    This document addresses the uncertainties about environmental aspects of Wood Combustion Systems that remain to be resolved through research and development. The resolution of these uncertainties may require adjustments in the technology program before it can be commercialized. The impacts and concerns presented in the document are treated generically without reference to specific predetermined sites unless these are known. Hence, site-specific implications are not generally included in the assessment. The report consists of two main sections which describe the energy resource base involved, characteristics of the technology, and introduce the environmental concerns of implementing the technology; and which review the concerns related to wood combustion systems which are of significance for the environment. It also examines the likelihood and consequence of findings which might impede wood commercialization such as problems and uncertainties stemming from current or anticipated environmental regulation, or costs of potential environmental controls. This document is not a formal NEPA document. Appropriate NEPA documentation will be prepared after a formal wood combustion commercialization program is approved by DOE.

  5. The Influence of Commodity Programs on Acreage Response to Market Price: With an Illustration Concerning Rice Policy in the United States

    OpenAIRE

    Jeffrey D. McDonald; Daniel A. Sumner

    2003-01-01

    Farm programs influence the parameters of typically estimated supply functions. We develop and apply an approach that uses detailed information about farm program incentives and constraints to identify underlying structural acreage response parameters when the data reflect behavior under complex government commodity programs. We illustrate the approach with data on rice acreage response to market price in the United States. For U.S. rice, estimates that fail to appropriately incorporate the p...

  6. Survey of a community-based infusion program for Australian patients with rheumatoid arthritis requiring treatment with tocilizumab: patient characteristics and drivers of patient satisfaction and patient-perceived benefits and concerns

    Directory of Open Access Journals (Sweden)

    Voight L

    2012-04-01

    Full Text Available Louisa VoightCoast Joint Care, Maroochydore, Queensland, AustraliaBackground: Tocilizumab is an effective therapy for patients with moderate to severe rheumatoid arthritis that is administered by infusion over one hour every 4 weeks. The community-based infusion (ACTiv program was introduced to Australia in August 2010 to provide accessible and convenient treatment for patients with rheumatoid arthritis who require tocilizumab. The primary objectives of this study were to determine the characteristics of patients in the ACTiv program, patient satisfaction, and patient-perceived benefits and concerns with the ACTiv program, and drivers of patient satisfaction and patient-perceived benefits and concerns.Methods: A voluntary self-administered survey was given to all 608 patients in the ACTiv program between January 27, 2011 and March 31, 2011.Results: A total of 351 surveys were returned completed, giving a response rate of 58% (351/608. Most patients in the ACTiv program were women aged 40–64 years, with a mean disease duration of 13.7 years and moderate disability, who had been in the ACTiv program for ≥5 months. Most patients (88%, 302/342 were either very satisfied or satisfied with the ACTiv program and believed that they were very unlikely or somewhat unlikely to switch from the ACTiv program (64%, 214/335. The most important benefit was the reassurance of receiving treatment from a trained nurse in a professional medical environment (33%, 102/309. The most important concern was the fear of side effects (48%, 134/280. The main drivers of patient satisfaction and patient-perceived benefits and concerns of patients were health profile, previous medication experience, and length of treatment time in the program.Conclusion: The ACTiv program is used by patients of various ages, family life situations, and locations. Patient satisfaction with the program is high, which enables patients to benefit from long-term use of tocilizumab

  7. 78 FR 17943 - Draft Program-Specific Guidance About Fixed Gauge Licenses

    Science.gov (United States)

    2013-03-25

    ... safety culture, security of radioactive materials, protection of sensitive information, and changes in... Materials and Environmental Management Programs; U.S. Nuclear Regulatory Commission, Washington, DC 20555... Environmental Management Programs. BILLING CODE 7590-01-P ...

  8. A Preliminary Trial of a Prototype Internet Dissonance-Based Eating Disorder Prevention Program for Young Women with Body Image Concerns

    Science.gov (United States)

    Stice, Eric; Rohde, Paul; Durant, Shelley; Shaw, Heather

    2012-01-01

    Objective: A group dissonance-based eating disorder prevention program, in which young women critique the thin ideal, reduces eating disorder risk factors and symptoms, but it can be difficult to identify school clinicians with the time and expertise to deliver the intervention. Thus, we developed a prototype Internet version of this program and…

  9. High- and Low-Level Dissonance-Based Eating Disorder Prevention Programs with Young Women with Body Image Concerns: An Experimental Trial

    Science.gov (United States)

    McMillan, Whitney; Stice, Eric; Rohde, Paul

    2011-01-01

    Objective: As cognitive dissonance is theorized to contribute to the effects of dissonance-based eating disorder prevention programs, we evaluated a high-dissonance version of this program against a low-dissonance version and a wait-list control condition to provide an experimental test of the mechanism of intervention effects. Method: Female…

  10. An Experimental Evaluation of Programed Instruction as One of Two Review Techniques for Two-Year College Students Concerned with Solving Acid-Base Chemical Equilibrium Problems.

    Science.gov (United States)

    Sharon, Jared Bear

    The major purpose of this study was to design and evaluate a programed instructional unit for a first year college chemistry course. The topic of the unit was the categorization and solution of acid-base equilibria problems. The experimental programed instruction text was used by 41 students and the fifth edition of Schaum's Theory and Problems of…

  11. Recommendations for Guidelines for Environment-Specific Magnetic-Field Measurements, Rapid Program Engineering Project #2

    Energy Technology Data Exchange (ETDEWEB)

    Electric Research and Management, Inc.; IIT Research Institute; Magnetic Measurements; Survey Research Center, University of California; T. Dan Bracken, Inc.

    1997-03-11

    The purpose of this project was to document widely applicable methods for characterizing the magnetic fields in a given environment, recognizing the many sources co-existing within that space. The guidelines are designed to allow the reader to follow an efficient process to (1) plan the goals and requirements of a magnetic-field study, (2) develop a study structure and protocol, and (3) document and carry out the plan. These guidelines take the reader first through the process of developing a basic study strategy, then through planning and performing the data collection. Last, the critical factors of data management, analysis reporting, and quality assurance are discussed. The guidelines are structured to allow the researcher to develop a protocol that responds to specific site and project needs. The Research and Public Information Dissemination Program (RAPID) is based on exposure to magnetic fields and the potential health effects. Therefore, the most important focus for these magnetic-field measurement guidelines is relevance to exposure. The assumed objective of an environment-specific measurement is to characterize the environment (given a set of occupants and magnetic-field sources) so that information about the exposure of the occupants may be inferred. Ideally, the researcher seeks to obtain complete or "perfect" information about these magnetic fields, so that personal exposure might also be modeled perfectly. However, complete data collection is not feasible. In fact, it has been made more difficult as the research field has moved to expand the list of field parameters measured, increasing the cost and complexity of performing a measurement and analyzing the data. The guidelines address this issue by guiding the user to design a measurement protocol that will gather the most exposure-relevant information based on the locations of people in relation to the sources. We suggest that the "microenvironment" become the base unit of area in a study, with

  12. Lessons from the Arkansas Cash and Counseling program: how the experiences of diverse older consumers and their caregivers address family policy concerns.

    Science.gov (United States)

    San Antonio, Patricia; Simon-Rusinowitz, Lori; Loughlin, Dawn; Eckert, J Kevin; Mahoney, Kevin J; Ruben, Kathleen Ann Depretis

    2010-01-01

    This paper addresses four family policy questions that policy makers often ask about consumer-directed services, examining issues such as quality, suitability, and fraud and abuse. Responses to these questions evolved from the experiences of diverse elder consumers and their caregivers who participated in IndependentChoices, the Arkansas site of the Cash and Counseling Demonstration and Evaluation (CCDE) program. Building on CCDE evaluation survey data, this analysis of in-home interviews with participants discussing their experiences of receiving, giving, and managing care demonstrates how the program allows consumers choices so they receive the services they want. At the same time, program flexibility allows policy makers to safeguard both consumers and program resources through the use of supports such as representatives, state consultants, and fiscal intermediaries. This article demonstrates how the Cash and Counseling model can address the needs of both consumers with diverse disabilities and policy makers.

  13. Specification and Verification of GPGPU programs using Permission-based Separation logic

    OpenAIRE

    Huisman, Marieke; Mihelcic, M.

    2013-01-01

    Graphics Processing Units (GPUs) are increasingly used for general-purpose applications because of their low price, energy efficiency and enormous computing power. Considering the importance of GPU applications, it is vital that the behaviour of GPU programs can be specified and proven correct formally. This paper presents our ideas how to verify GPU programs written in OpenCL, a platform-independent low-level programming language. Our verification approach is modular, based on permission-bas...

  14. Exploring the Effects of Specific, Hands-On Interventions, on Environmental Science Topics in Teacher Education Programs

    Science.gov (United States)

    Bullock, S. M.; Hayhoe, D.

    2012-12-01

    With increased concern over the environment, all Ontario students now study soils, energy conservation, water systems, and climate change & the greenhouse effect in Grades 3, 5, 7, 8 and 10. Unfortunately, many prospective teachers at the elementary and intermediate levels come to teacher education programs with little or no formal science education beyond their own experiences as students in the K-12 system. We devised a series of concept tests (some binary choice, some multiple choice) designed to assess teacher candidates' conceptual understandings of soils, energy, water systems, and climate change and the greenhouse effect - the very content they are expected to teach their future students in the school system. We administered a pre-test to our students at two institutions to establish a baseline of their understanding. Then, we specifically devoted class time to exploring each of these themes in our science curriculum methods courses in order using research-based principles of teaching devoted to promoting conceptual change through the use of hands-on, inquiry approaches in science. After a few months had passed, we again administered the same tests to teacher candidates to measure candidates' conceptual gain. Some teacher candidates also participated in follow-up focus group interviews so that they could have the opportunity to articulate their understandings of concepts in environmental science using their own words. In this poster we will report on data collected for this project over the past two academic years. We have reached two broad conclusions. First, teacher candidates know a considerable amount about the four environmental topics that were selected, despite the fact that most participants in the research did not have post-secondary training in science. For example, participants tended to know that planting different crops on the soil in different years helps to maintain fertile soils and that warmer oceans will cause an increase in the severity of

  15. Beliefs and perceived norms concerning smoking cessation program recruitment among African American teen smokers: what appeals to youth and what turns them away.

    Science.gov (United States)

    Peters, Ronald J; Meshack, Angela; Kelder, Steven H; Springer, Andrew; Agurcia, Carolyn

    2011-01-01

    A qualitative approach was used to investigate the beliefs and perceived norms about participation in smoking cessation programs among a sample of African American alternative school students (N = 53), aged 14 to 18 years old, in the United States who were current smokers. The authors found that the majority of participants felt that smoking cessation programs were not effective, caused smoking, or lacked activities. Both boys and girls believed that communication sources that provided direct messages in real situations were the best motivators or incentives for African American youth recruitment into smoking cessation programs. These findings support research that African Americans are more attentive to communications that involve direct personal stimuli. In addition, African Americans place heavy emphasis on source and message style to determine credibility of the intervention strategy.

  16. A Guide to Educational Specifications for a Comprehensive Elementary Teacher Education Program.

    Science.gov (United States)

    Wiersma, William

    The teacher education model developed by the consortium of Ohio universities contains 818 specifications which include in excess of 2,000 behavioral objectives. Each specification identifies the behavioral objectives. Specifications were developed within five broad contexts and apply to one or more of the six target populations involved in…

  17. Experiences of Students with Specific Learning Disorder (Including ADHD) in Online College Degree Programs: A Phenomenological Study

    Science.gov (United States)

    Bunch, Seleta LeAnn

    2016-01-01

    Enrollment in online degree programs is rapidly expanding due to the convenience and affordability offered to students and improvements in technology. The purpose of this hermeneutical phenomenological study was to understand the shared experiences of students with documented specific learning disorders (including Attention-Deficit/Hyperactivity…

  18. Specific and Optional Curriculum: An Experience in the Undergraduate Program of Chemical Engineering in Cienfuegos University, Cuba

    Science.gov (United States)

    Martínez, Yolanda García; Velázquez, Claudia Alvarado; Castillo, Rolando Delgado

    2016-01-01

    This paper pursues to define the pillars for designing the specific (SC) and optional curricula (OC) of Unit Operations and Processes (UOP) Discipline in the Chemical Engineering Program. To achieve this objective a methodology was developed, which was characterized by the participation of every member in the educational process: professors,…

  19. A Practical Procedure for Instituting a Chore and Allowance Program for Grade School Children: Specific Guidelines for Clinicians.

    Science.gov (United States)

    Neul, Shari K. T.; Drabman, Ronald S.

    2001-01-01

    This article provides a use plan for instituting and maintaining a successful chore and allowance program for children. Specific guidelines are outlined regarding how to teach children basic money management skills. Explicit examples are offered for teaching these skills that can be easily adopted by parents and clinicians who specialize in…

  20. Empathic concern drives costly altruism

    OpenAIRE

    FeldmanHall, Oriel; Dalgleish, Tim; Evans, Davy; Mobbs, Dean

    2015-01-01

    Why do we self-sacrifice to help others in distress? Two competing theories have emerged, one suggesting that prosocial behavior is primarily motivated by feelings of empathic other-oriented concern, the other that we help mainly because we are egoistically focused on reducing our own discomfort. Here we explore the relationship between costly altruism and these two sub-processes of empathy, specifically drawing on the caregiving model to test the theory that trait empathic concern (e.g. gene...

  1. Insights from Smart Meters: Identifying Specific Actions, Behaviors, and Characteristics That Drive Savings in Behavior-Based Programs

    Energy Technology Data Exchange (ETDEWEB)

    Todd, A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Perry, M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Smith, B. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sullivan, M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Cappers, P. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldman, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-12-01

    In this report, we use smart meter data to analyze specific actions, behaviors, and characteristics that drive energy savings in a BB program. Specifically, we examine a Home Energy Report (HER) program. These programs typically obtain 1% to 3% annual savings, and recent studies have shown hourly savings of between 0.5% and 3%.1 But what is driving these savings? What types of households tend to be “high-savers,” and what behaviors are they adopting? There are several possibilities: one-time behaviors (e.g., changing thermostat settings), reoccurring habitual behaviors (e.g., turning off lights), and equipment purchase behaviors (e.g., energy efficient appliances); these may vary across households, regions, and over time.

  2. Insights from Smart Meters. Identifying Specific Actions, Behaviors and Characteristics that drive savings in Behavior-Based Programs

    Energy Technology Data Exchange (ETDEWEB)

    Todd, Annika [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Perry, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Smith, Brian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Pacific Gas & Electric, San Francisco, CA (United States); Sullivan, Michael [Nexant, San Francisco, CA (United States); Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldman, Charles A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2014-12-01

    In this report, we use smart meter data to analyze specific actions, behaviors, and characteristics that drive energy savings in a behavior-based (BB) program. Specifically, we examine a Home Energy Report (HER) program. These programs typically obtain 1% to 3% annual savings, and recent studies have shown hourly savings of between 0.5% and 3%. But what is driving these savings? What types of households tend to be “high-savers”, and what behaviors are they adopting? There are several possibilities: one-time behaviors (e.g., changing thermostat settings); reoccurring habitual behaviors (e.g., turning off lights); and equipment purchase behaviors (e.g., energy efficient appliances), and these may vary across households, regions, and over time.

  3. Parental vaccine concerns in Kentucky.

    Science.gov (United States)

    Smith, Michael J; Woods, Charles R; Marshall, Gary S

    2009-09-01

    An increasing number of parents are questioning the safety and necessity of routine childhood immunizations. Locally produced vaccine risk communication materials may be effective in reassuring these parents. However, little is known about specific vaccine safety concerns in the state of Kentucky. An Internet-based survey focusing on parental vaccine safety concerns and potential vaccine risk communication strategies was sent to all members of the Kentucky Chapter of the Amerian Academy of Pediatrics. There were 121 respondents who routinely administered childhood vaccines. Of these, 85% reported parental concern about the combined measles-mumps-rubella (MMR) vaccine. Concerns about the influenza and human papillomavirus (HPV) vaccines were also frequent. Of the respondents, 46% noted parental skepticism about all vaccines in general. However, refusal of all vaccines was uncommon in most practices (median 1%, interquartile range 1%-3%). The belief that vaccines cause autism was the most prevalent parental concern, reported by 70% of pediatricians. Physicians also reported that a list of reliable vaccine information Websites and pamphlets addressing common vaccine safety concerns would be the most helpful materials to use during their discussions with concerned parents. These findings suggest that specific information about the MMR, influenza, and HPV vaccines, as well as data refuting the putative link between vaccines and autism would be useful to physicians who administer vaccinations. Respondents were especially interested in reliable vaccine information on the Internet. The Websites listed below offer accurate scientific information about vaccines and the diseases they prevent.

  4. 76 FR 35319 - Competitive and Noncompetitive Non-Formula Federal Assistance Programs-Specific Administrative...

    Science.gov (United States)

    2011-06-17

    ... ranchers; innovative farm and ranch transfer strategies; entrepreneurship and business training; model land... Extension Directors (ASRED) and National Sustainable Agriculture Coalition (NSAC). ASRED provided two.... NSAC points to the success of the Sustainable Agriculture Research and Education (SARE) Program which...

  5. Program Specificity for Ptf1a in Pancreas versus Neural Tube Development Correlates with Distinct Collaborating Cofactors and Chromatin Accessibility

    Science.gov (United States)

    Meredith, David M.; Borromeo, Mark D.; Deering, Tye G.; Casey, Bradford H.; Savage, Trisha K.; Mayer, Paul R.; Hoang, Chinh; Tung, Kuang-Chi; Kumar, Manonmani; Shen, Chengcheng; Swift, Galvin H.

    2013-01-01

    The lineage-specific basic helix-loop-helix transcription factor Ptf1a is a critical driver for development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies for the program-specific functions of Ptf1a, we identified bound genomic regions in vivo during development of both tissues. Most regions bound by Ptf1a are specific to each tissue, lie near genes needed for proper formation of each tissue, and coincide with regions of open chromatin. The specificity of Ptf1a binding is encoded in the DNA surrounding the Ptf1a-bound sites, because these regions are sufficient to direct tissue-restricted reporter expression in transgenic mice. Fox and Sox factors were identified as potential lineage-specific modifiers of Ptf1a binding, since binding motifs for these factors are enriched in Ptf1a-bound regions in pancreas and neural tube, respectively. Of the Fox factors expressed during pancreatic development, Foxa2 plays a major role. Indeed, Ptf1a and Foxa2 colocalize in embryonic pancreatic chromatin and can act synergistically in cell transfection assays. Together, these findings indicate that lineage-specific chromatin landscapes likely constrain the DNA binding of Ptf1a, and they identify Fox and Sox gene families as part of this process. PMID:23754747

  6. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

    Science.gov (United States)

    Kløverpris, Henrik N.; McGregor, Reuben; McLaren, James E.; Ladell, Kristin; Stryhn, Anette; Koofhethile, Catherine; Brener, Jacqui; Chen, Fabian; Riddell, Lynn; Graziano, Luzzi; Klenerman, Paul; Leslie, Alasdair; Buus, Søren; Price, David A.; Goulder, Philip

    2014-01-01

    Objectives: Although CD8+ T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (PD-1), CD244 and lymphocyte activation gene-3 (LAG-3), which modulate the functional capabilities of CD8+ T cells. Design and methods: Here, we used an array of different human leukocyte antigen (HLA)-B∗15 : 03 and HLA-B∗42 : 01 tetramers to characterize inhibitory receptor expression as a function of differentiation on HIV-1-specific CD8+ T-cell populations (n = 128) spanning 11 different epitope targets. Results: Expression levels of PD-1, but not CD244 or LAG-3, varied substantially across epitope specificities both within and between individuals. Differential expression of PD-1 on T-cell receptor (TCR) clonotypes within individual HIV-1-specific CD8+ T-cell populations was also apparent, independent of clonal dominance hierarchies. Positive correlations were detected between PD-1 expression and plasma viral load, which were reinforced by stratification for epitope sequence stability and dictated by effector memory CD8+ T cells. Conclusion: Collectively, these data suggest that PD-1 expression on HIV-1-specific CD8+ T cells tracks antigen load at the level of epitope specificity and TCR clonotype usage. These findings are important because they provide evidence that PD-1 expression levels are influenced by peptide/HLA class I antigen exposure. PMID:24906112

  7. Giving voice to cancer patients: assessing non-specific effects of an integrative oncology therapeutic program via short patient narratives.

    Science.gov (United States)

    Keshet, Yael; Schiff, Elad; Samuels, Noah; Ben-Arye, Eran

    2015-02-01

    The aim of this study was to assess patient perspectives regarding non-specific effects of a complementary medicine (CM) consultation and intervention within an integrative oncology setting. Patients undergoing chemotherapy in a community-based oncology service were referred by oncology healthcare providers to an integrative oncology physician trained in CM-oriented supportive care. Assessment of concerns and well-being was made using the Measure Yourself Concerns and Wellbeing questionnaire, at baseline and after 3 months of CM treatments, which were designed to improve quality of life (QoL) outcomes. Patients were asked to describe the most important aspects of the integrative treatment process. Free-text narratives were examined using content analysis with ATLAS.Ti software for systematic coding. Of 152 patients' narratives analyzed, 44% reported an experience of patient-centered care, including CM practitioners' approach of togetherness, uniqueness, and the invoking of an internal process. CM practitioner approach was experienced within a context of an enhanced sense of confidence; gaining a different perspective; and acquiring emotional resilience and empowerment. Short patient narratives should be considered for patient-reported outcomes, expressing perspectives of both effects and experience of care. CM may promote patient QoL-related outcomes through non-specific effects, enhancing patient-centered care. The benefits of CM dependent on general therapeutic incidental aspects (i.e., common factors) warrant attention regarding non-specific components of treatment. Copyright © 2014 John Wiley & Sons, Ltd.

  8. International Code Assessment and Applications Program: Summary of code assessment studies concerning RELAP5/MOD2, RELAP5/MOD3, and TRAC-B. International Agreement Report

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, R.R. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1993-12-01

    Members of the International Code Assessment Program (ICAP) have assessed the US Nuclear Regulatory Commission (USNRC) advanced thermal-hydraulic codes over the past few years in a concerted effort to identify deficiencies, to define user guidelines, and to determine the state of each code. The results of sixty-two code assessment reviews, conducted at INEL, are summarized. Code deficiencies are discussed and user recommended nodalizations investigated during the course of conducting the assessment studies and reviews are listed. All the work that is summarized was done using the RELAP5/MOD2, RELAP5/MOD3, and TRAC-B codes.

  9. Specifications of the equations for LEAP Model 22C. [Long-Term Energy Analysis Program

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, M.; Alsmiller, R.G. Jr.; Barish, J.

    1981-03-01

    This report describes the equations implemented in the Long-Term Energy Analysis Program (LEAP) Model 22C. The equilibrium equations of each of the processes contained in the LEAP Model 22C are specified, and the interrelations of the various equations are discussed. No attempt is made to derive the equations or to discuss their validity from an economic point of view.

  10. GirlPOWER! Strengthening Mentoring Relationships through a Structured, Gender-Specific Program

    Science.gov (United States)

    Pryce, Julia M.; Silverthorn, Naida; Sanchez, Bernadette; DuBois, David L.

    2010-01-01

    The authors examine GirlPOWER! an innovative program that uses structure and group-based activities to enhance one-to-one mentoring relationships for young adolescent girls from the perspective of the focus, purpose, and authorship dimensions of mentoring relationships that Karcher and Nakkula described. The discussion draws on several sources of…

  11. Safety in the Chemical Laboratory: Safety in the Chemistry Laboratories: A Specific Program.

    Science.gov (United States)

    Corkern, Walter H.; Munchausen, Linda L.

    1983-01-01

    Describes a safety program adopted by Southeastern Louisiana University. Students are given detailed instructions on laboratory safety during the first laboratory period and a test which must be completely correct before they are allowed to return to the laboratory. Test questions, list of safety rules, and a laboratory accident report form are…

  12. Course Design and Delivery Specifications as a Tool for Ensuring Quality in an Online Training Program

    Science.gov (United States)

    Docq, Françoise

    2015-01-01

    This case discusses the design, implementation, and regulation of a hybrid training program (60 credits over two years) organised by three business schools in Europe, and stretching over a five-year period. Following an incremental design process, the design team faced multiple challenges, from finding the added value of hybridization to choosing…

  13. Productive High Performance Parallel Programming with Auto-tuned Domain-Specific Embedded Languages

    Science.gov (United States)

    2013-01-02

    http://dl.acm. org/citation.cfm?id=645980.674267. [93] Inc. PLT Scheme. The Racket Language. 2012. URL: http://racket-lang.org. [94] Sebastian Pop...URL: http://pypi.python.org/pypi. [100] Python Programming Language - Offical Website. 2012. URL: http://www.python.org. [101] Gabriel Rivera and Chau

  14. The broadened-specification fuels combustion technology program at Pratt and Whitney Aircraft

    Science.gov (United States)

    Lohmann, R. P.

    1980-01-01

    The impact of the use of broadened specification fuels on combustor design was investigated. Particular emphasis was placed on establishing the viability of various combustor modifications to permit the use of broadened specification fuels while meeting exhaust emissions and performance specifications and maintaining acceptable combustor operational and durability characteristics. Three different combustor concepts will be evaluated. Various design modifications on the operating capability of each of the combustor concepts with experimental referee broadened specification Fuel. The modifications that were evaluated included perturbations of the combustor airflow schedules to alter local stoichiometry and residence time histories revisions to the fuel injectors, and variations in liner cooling including the use of thermal barrier coatings and/or advanced cooling concepts.

  15. Simplifying the construction of domain-specific automatic programming systems: The NASA automated software development workstation project

    Science.gov (United States)

    Allen, Bradley P.; Holtzman, Peter L.

    1988-01-01

    An overview is presented of the Automated Software Development Workstation Project, an effort to explore knowledge-based approaches to increasing software productivity. The project focuses on applying the concept of domain specific automatic programming systems (D-SAPSs) to application domains at NASA's Johnson Space Flight Center. A version of a D-SAPS developed in Phase 1 of the project for the domain of space station momentum management is described. How problems encountered during its implementation led researchers to concentrate on simplifying the process of building and extending such systems is discussed. Researchers propose to do this by attacking three observed bottlenecks in the D-SAPS development process through the increased automation of the acquisition of programming knowledge and the use of an object oriented development methodology at all stages of the program design. How these ideas are being implemented in the Bauhaus, a prototype workstation for D-SAPS development is discussed.

  16. A Domain-Specific Language for Programming Self-Reconfigurable Robots

    DEFF Research Database (Denmark)

    Schultz, Ulrik Pagh; Christensen, David Johan; Støy, Kasper

    2007-01-01

    , self-reconfigurable robots, we have developed a declarative, role-based language that allows the programmer to define roles and behavior independently of the concrete physical structure of the robot. Roles are compiled to mobile code fragments that distribute themselves over the physical structure......A self-reconfigurable robot is a robotic device that can change its own shape. Self-reconfigurable robots are commonly built from multiple identical modules that can manipulate each other to change the shape of the robot. The robot can also perform tasks such as locomotion without changing shape....... Programming a modular, self-reconfigurable robot is however a complicated task: the robot is essentially a real-time, distributed embedded system, where control and communication paths often are tightly coupled to the current physical configuration of the robot. To facilitate the task of programming modular...

  17. Space Shuttle Program (SSP) Shock Test and Specification Experience for Reusable Flight Hardware Equipment

    Science.gov (United States)

    Larsen, Curtis E.

    2012-01-01

    As commercial companies are nearing a preliminary design review level of design maturity, several companies are identifying the process for qualifying their multi-use electrical and mechanical components for various shock environments, including pyrotechnic, mortar firing, and water impact. The experience in quantifying the environments consists primarily of recommendations from Military Standard-1540, Product Verification Requirement for Launch, Upper Stage, and Space Vehicles. Therefore, the NASA Engineering and Safety Center (NESC) formed a team of NASA shock experts to share the NASA experience with qualifying hardware for the Space Shuttle Program (SSP) and other applicable programs and projects. Several team teleconferences were held to discuss past experience and to share ideas of possible methods for qualifying components for multiple missions. This document contains the information compiled from the discussions

  18. Breast and cervical cancer screening among Latinas attending culturally specific educational programs.

    Science.gov (United States)

    Jandorf, Lina; Bursac, Zoran; Pulley, Leavonne; Trevino, Michelle; Castillo, Anabella; Erwin, Deborah O

    2008-01-01

    Latinas in the United States have higher morbidity and mortality rates for breast and cervical cancers (compared with non-Latina Whites), often due to lower screening rates. A community-based participatory research (CBPR) approach could help to improve screening rates by creating a culturally customized educational program for Latino men and women addressing low knowledge, gender roles, and spirituality. This study was designed to assess the effectiveness of a culturally customized program (Esperanza y Vida [Hope and Life]) in increasing breast and cervical cancer screening among Latinas, and to examine how screening rates related to changes in cancer knowledge, differences in ethnic origins, and geographic location. Participants were recruited to attend either a breast and cervical (intervention) or diabetes (control) education program, within a randomized plan. Sixty-nine programs (44 intervention; 25 control) were conducted in Arkansas (AR; n = 39) and New York City (NYC; n = 30) with a total of 847 Latino men and women. Telephone follow-up data were collected on 49% of the women who consented to being contacted 2 months postintervention. At the 2-month follow-up call, screening rates were significantly higher for the intervention versus the control group for clinical breast examination (CBE; 48% vs. 31%; adjusted odds ratio [aOR], 2.2; 95% confidence interval [CI], 1.1-4.2), breast self-examination (45% vs. 27%; aOR, 2.3; 95% CI, 1.1-5.0), and Pap testing (51% vs. 30%; aOR, 3.9; 95% CI, 1.1-14.1), but not for mammography (67% vs. 58%; aOR, 0.7; 95% CI, 0.1-3.6). The aORs accounted for the significant effects of study site (AR vs. NYC) and marital status. Esperanza y Vida has the potential to reduce health disparities in breast and cervical cancer morbidity and mortality rates through increasing cancer screening and thereby increasing early detection.

  19. Genomic selection needs to be carefully assessed to meet specific requirements in livestock breeding programs

    Science.gov (United States)

    Jonas, Elisabeth; de Koning, Dirk-Jan

    2015-01-01

    Genomic selection is a promising development in agriculture, aiming improved production by exploiting molecular genetic markers to design novel breeding programs and to develop new markers-based models for genetic evaluation. It opens opportunities for research, as novel algorithms and lab methodologies are developed. Genomic selection can be applied in many breeds and species. Further research on the implementation of genomic selection (GS) in breeding programs is highly desirable not only for the common good, but also the private sector (breeding companies). It has been projected that this approach will improve selection routines, especially in species with long reproduction cycles, late or sex-limited or expensive trait recording and for complex traits. The task of integrating GS into existing breeding programs is, however, not straightforward. Despite successful integration into breeding programs for dairy cattle, it has yet to be shown how much emphasis can be given to the genomic information and how much additional phenotypic information is needed from new selection candidates. Genomic selection is already part of future planning in many breeding companies of pigs and beef cattle among others, but further research is needed to fully estimate how effective the use of genomic information will be for the prediction of the performance of future breeding stock. Genomic prediction of production in crossbreeding and across-breed schemes, costs and choice of individuals for genotyping are reasons for a reluctance to fully rely on genomic information for selection decisions. Breeding objectives are highly dependent on the industry and the additional gain when using genomic information has to be considered carefully. This review synthesizes some of the suggested approaches in selected livestock species including cattle, pig, chicken, and fish. It outlines tasks to help understanding possible consequences when applying genomic information in breeding scenarios. PMID

  20. Genomic selection needs to be carefully assessed to meet specific requirements in livestock breeding programs

    Directory of Open Access Journals (Sweden)

    Elisabeth eJonas

    2015-02-01

    Full Text Available Genomic selection is a promising development in agriculture, aiming improved production by exploiting molecular genetic markers to design novel breeding programs and to develop new markers-based models for genetic evaluation. It opens opportunities for research, as novel algorithms and lab methodologies are developed. Genomic selection can be applied in many breeds and species. Further research on the implementation of genomic selection in breeding programs is highly desirable not only for the common good, but also the private sector (breeding companies. It has been projected that this approach will improve selection routines, especially in species with long reproduction cycles, late or sex-limited or expensive trait recording and for complex traits. The task of integrating genomic selection into existing breeding programs is, however, not straightforward. Despite successful integration into breeding programs for dairy cattle, it has yet to be shown how much emphasis can be given to the genomic information and how much additional phenotypic information is needed from new selection candidates. Genomic selection is already part of future planning in many breeding companies of pigs and beef cattle among others, but further research is needed to fully estimate how effective the use of genomic information will be for the prediction of the performance of future breeding stock. Genomic prediction of production in crossbreeding and across-breed schemes, costs and choice of individuals for genotyping are reasons for a reluctance to fully rely on genomic information for selection decisions. Breeding objectives are highly dependent on the industry and the additional gain when using genomic information has to be considered carefully. This review synthesizes some of the suggested approaches in selected livestock species including cattle, pig, chicken and fish. It outlines tasks to help understanding possible consequences when applying genomic information in

  1. An Analysis of Specific Cognizance Symbol Material in the Advanced Traceability and Control (ATAC) Program

    Science.gov (United States)

    1992-12-01

    100.00% 667 194 T-6: GOVERNMENT SCREENING TIMES AT THE SAN DIEGO HUB FOR 7E COG Cumuktlv Day Couna Poronld PorN .•_ 0.5 7 0.40% 0.40% 1.5 U 6.11% 6.50...PROGRAM . . - 11 1.NODEs ............ .................... .. 11 2. HUBs ............. .................... 13 3.Receiving, Screening, Processing...Packing, and Shipping at HUBs ........ .............. .. 13 III. RESEARCH METHODOLOGY ....... .............. .. 18 A.DATABASE

  2. Results of a Pilates exercise program in patients with chronic non-specific low back pain: a randomized controlled trial.

    Science.gov (United States)

    Valenza, M C; Rodríguez-Torres, J; Cabrera-Martos, I; Díaz-Pelegrina, A; Aguilar-Ferrándiz, M E; Castellote-Caballero, Y

    2017-06-01

    To investigate the effects of a Pilates exercise program on disability, pain, lumbar mobility, flexibility and balance in patients with chronic non-specific low back pain. Randomized controlled trial. University laboratory. A total of 54 patients with chronic non-specific low back pain. Patients were randomly allocated to an experimental group ( n=27) included in a Pilates exercise program or to a control group ( n=27) receiving information in a form of a leaflet. Disability (Roland-Morris Disability Questionnaire and Oswestry Disability Index), current, average and pain at it least and at its worst (Visual Analogue Scales), lumbar mobility (modified Shober test), flexibility (finger-to-floor test) and balance (single limb stance test) were measured at baseline and after the intervention. A between-group analysis showed significant differences in the intervention group compared to the control group for both disability scores, the Rolland-Morris questionnaire (mean change±standard deviation of 5.31±3.37 and 2.40±6.78 respectively and between-groups mean difference of 3.2 ± 4.12, p=0.003) and the Oswestry Disability Index ( ppain ( p=0.002) and pain at it least ( p=0.033), flexibility (0.032) and balance (0.043). An 8-week Pilates exercise program is effective in improving disability, pain, flexibility and balance in patients with chronic non-specific low back pain.

  3. Specific balance training included in an endurance-resistance exercise program improves postural balance in elderly patients undergoing haemodialysis.

    Science.gov (United States)

    Frih, Bechir; Mkacher, Wajdi; Jaafar, Hamdi; Frih, Ameur; Ben Salah, Zohra; El May, Mezry; Hammami, Mohamed

    2018-04-01

    The purpose of this study was to evaluate the effects of 6 months of specific balance training included in endurance-resistance program on postural balance in haemodialysis (HD) patients. Forty-nine male patients undergoing HD were randomly assigned to an intervention group (balance training included in an endurance-resistance training, n = 26) or a control group (resistance-endurance training only, n = 23). Postural control was assessed using six clinical tests; Timed Up and Go test, Tinetti Mobility Test, Berg Balance Scale, Unipodal Stance test, Mini-Balance Evaluation Systems Test and Activities Balance Confidence scale. All balance measures increased significantly after the period of rehabilitation training in the intervention group. Only the Timed Up and Go, Berg Balance Scale, Mini-Balance Evaluation Systems Test and Activities Balance Confidence scores were improved in the control group. The ranges of change in these tests were greater in the balance training group. In HD patients, specific balance training included in a usual endurance-resistance training program improves static and dynamic balance better than endurance-resistance training only. Implications for rehabilitation Rehabilitation using exercise in haemodialysis patients improved global mobility and functional abilities. Specific balance training included in usual endurance resistance training program could lead to improved static and dynamic balance.

  4. A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming.

    Directory of Open Access Journals (Sweden)

    Alejandro Colaneri

    Full Text Available Cell specific states of the chromatin are programmed during mammalian development. Dynamic DNA methylation across the developing embryo guides a program of repression, switching off genes in most cell types. Thus, the majority of the tissue specific differentially methylated sites (TS-DMS must be un-methylated CpGs.Comparison of expanded Methyl Sensitive Cut Counting data (eMSCC among four tissues (liver, testes, brain and kidney from three C57BL/6J mice, identified 138,052 differentially methylated sites of which 23,270 contain CpGs un-methylated in only one tissue (TS-DMS. Most of these CpGs were located in intergenic regions, outside of promoters, CpG islands or their shores, and up to 20% of them overlapped reported active enhancers. Indeed, tissue-specific enhancers were up to 30 fold enriched in TS-DMS. Testis showed the highest number of TS-DMS, but paradoxically their associated genes do not appear to be specific to the germ cell functions, but rather are involved in organism development. In the other tissues the differentially methylated genes are associated with tissue-specific physiological or anatomical functions. The identified sets of TS-DMS quantify epigenetic distances between tissues, generated during development. We applied this concept to measure the extent of reprogramming in the liver of mice exposed to in utero or early postnatal nutritional stress. Different protocols of food restriction reprogrammed the liver methylome in different but reproducible ways.Thus, each identified set of differentially methylated sites constituted an epigenetic signature that traced the developmental programing or the early nutritional reprogramming of each exposed mouse. We propose that our approach has the potential to outline a number of disease-associated epigenetic states. The composition of differentially methylated CpGs may vary with each situation, behaving as a composite variable, which can be used as a pre-symptomatic marker for

  5. Formal semantic specifications as implementation blueprints for real-time programming languages

    Science.gov (United States)

    Feyock, S.

    1981-01-01

    Formal definitions of language and system semantics provide highly desirable checks on the correctness of implementations of programming languages and their runtime support systems. If these definitions can give concrete guidance to the implementor, major increases in implementation accuracy and decreases in implementation effort can be achieved. It is shown that of the wide variety of available methods the Hgraph (hypergraph) definitional technique (Pratt, 1975), is best suited to serve as such an implementation blueprint. A discussion and example of the Hgraph technique is presented, as well as an overview of the growing body of implementation experience of real-time languages based on Hgraph semantic definitions.

  6. High Performance Computing - Power Application Programming Interface Specification Version 2.0.

    Energy Technology Data Exchange (ETDEWEB)

    Laros, James H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grant, Ryan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Levenhagen, Michael J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Olivier, Stephen Lecler [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pedretti, Kevin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ward, H. Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Younge, Andrew J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-03-01

    Measuring and controlling the power and energy consumption of high performance computing systems by various components in the software stack is an active research area. Implementations in lower level software layers are beginning to emerge in some production systems, which is very welcome. To be most effective, a portable interface to measurement and control features would significantly facilitate participation by all levels of the software stack. We present a proposal for a standard power Application Programming Interface (API) that endeavors to cover the entire software space, from generic hardware interfaces to the input from the computer facility manager.

  7. Cost Savings From the Provision of Specific Methods of Contraception in a Publicly Funded Program

    Science.gov (United States)

    Rostovtseva, Daria P.; Brindis, Claire D.; Biggs, M. Antonia; Hulett, Denis; Darney, Philip D.

    2009-01-01

    Objectives. We examined the cost-effectiveness of contraceptive methods dispensed in 2003 to 955 000 women in Family PACT (Planning, Access, Care and Treatment), California's publicly funded family planning program. Methods. We estimated the number of pregnancies averted by each contraceptive method and compared the cost of providing each method with the savings from averted pregnancies. Results. More than half of the 178 000 averted pregnancies were attributable to oral contraceptives, one fifth to injectable methods, and one tenth each to the patch and barrier methods. The implant and intrauterine contraceptives were the most cost-effective, with cost savings of more than $7.00 for every $1.00 spent in services and supplies. Per $1.00 spent, injectable contraceptives yielded savings of $5.60; oral contraceptives, $4.07; the patch, $2.99; the vaginal ring, $2.55; barrier methods, $1.34; and emergency contraceptives, $1.43. Conclusions. All contraceptive methods were cost-effective—they saved more in public expenditures for unintended pregnancies than they cost to provide. Because no single method is clinically recommended to every woman, it is medically and fiscally advisable for public health programs to offer all contraceptive methods. PMID:18703437

  8. Nonconventional amide bond formation catalysis: programming enzyme specificity with substrate mimetics

    Directory of Open Access Journals (Sweden)

    Bordusa F.

    2000-01-01

    Full Text Available This article reports on the design and characteristics of substrate mimetics in protease-catalyzed reactions. Firstly, the basis of protease-catalyzed peptide synthesis and the general advantages of substrate mimetics over common acyl donor components are described. The binding behavior of these artificial substrates and the mechanism of catalysis are further discussed on the basis of hydrolysis, acyl transfer, protein-ligand docking, and molecular dynamics studies on the trypsin model. The general validity of the substrate mimetic concept is illustrated by the expansion of this strategy to trypsin-like, glutamic acid-specific, and hydrophobic amino acid-specific proteases. Finally, opportunities for the combination of the substrate mimetic strategy with the chemical solid-phase peptide synthesis and the use of substrate mimetics for non-peptide organic amide synthesis are presented.

  9. Diabetes-Specific Nutrition Algorithm: A Transcultural Program to Optimize Diabetes and Prediabetes Care

    OpenAIRE

    Mechanick, Jeffrey I.; Marchetti, Albert E.; Apovian, Caroline; Benchimol, Alexander Koglin; Bisschop, Peter H.; Bolio-Galvis, Alexis; Hegazi, Refaat A.; Jenkins, David; Mendoza, Enrique; Sanz, Miguel Leon; Sheu, Wayne Huey-Herng; Tatti, Patrizio; Tsang, Man-Wo; Hamdy, Osama

    2012-01-01

    Type 2 diabetes (T2D) and prediabetes have a major global impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. To mitigate this disease burden, interventions of proven effectiveness must be used. Evidence shows that nutrition therapy improves glycemic control and reduces the risks of diabetes and its complications. Accordingly, diabetes-specific nutrition therapy should be incorporated into comprehensive patient managemen...

  10. Characterization of Factors Affecting Attainment of Glycemic Control in Asian Americans With Diabetes in a Culturally Specific Program

    Science.gov (United States)

    Le, Hung; Wong, Sophia; Iftikar, Tracy; Keenan, Hillary; King, George L.; Hsu, William C.

    2014-01-01

    Purpose The purpose of this study is to examine the effectiveness of a culturally specific pilot clinic for Asian Americans (AA) in reaching glycemic target and to characterize factors affecting the attainment of glycemic control in comparison with white counterparts. Methods This electronic health record review included all new AA patients with type 2 diabetes (n = 109) in a culturally specific program and a randomly selected sample of new white patients with type 2 diabetes (n = 218) in the adult clinic within the same time period and diabetes center. Results AA and whites had a comparable proportion of patients with A1C ≤7% (32.1%, 34.9%; P = .621) at baseline and after 12 months of care (48.6%, 56.0%; P = .210), with a similar A1C decline (−0.9% ± 1.6%, −0.8% ± 1.7%, P = .710) by 12 months. Factors associated with the lack of success in reaching target in AA but not in whites included older age, lower educational attainment, less likelihood of having health insurance, and a need for more educational visits. The percentage of AA reaching A1C ≤7%, as compared to whites, worsened among those with highest initial A1C when stratified by ascending quartiles (96.7% vs 85.2%, P = .101; 61.9% vs 58.9%, P = .813; 24.0% vs 37.7%, P = .230; 15.2% vs 35.4%, P = .044). Conclusion While a culturally specific diabetes program in a specialty setting achieved a similar glycemic outcome for AA compared with whites, reasons for not reaching glycemic target differed. The findings suggest that the elimination of diabetes disparities requires not only culturally and linguistically specific programs, but must also identify and address the socio-environmental differences unique to each population. PMID:23771841

  11. Efectos de un programa de alta precoz sobre las preocupaciones de los padres de niños prematuros (Effects on an early discharge program on the concerns of parents of preterm infants

    Directory of Open Access Journals (Sweden)

    Manuel Fernández-Alcántara

    2015-08-01

    Full Text Available The birth of a premature infant has a striking emotional impact on the parents, especially when the hospitalization period is long. Early discharge programs are an effective tool to facilitate the transition to home and have beneficial effects. However, few studies have investigated the effects of these programs on parents during the post-discharge period and how are they related to changes in family dynamics. This article explored the experiences and obstacles faced by parents of preterm infants after discharge. The study followed a qualitative design using a descriptive phenomenological approach. Purposive sampling was used and a total of 23 parents participated. Data collection ended when theoretical saturation was reached.The parents were assessed using semi-structured interviews. A thematic analysis was conducted, which identified three central themes: concerns of the parents, emotions after discharge, and changes in life. The results indicate the importance of the early discharge program, which is associated with many positive emotions in parents. Participation in the early discharge program was associated with increased confidence regarding caring and improved skills related to managing some of the complex emotions associated with discharge.

  12. High Performance Computing - Power Application Programming Interface Specification Version 1.4

    Energy Technology Data Exchange (ETDEWEB)

    Laros III, James H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); DeBonis, David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Grant, Ryan [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Kelly, Suzanne M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Levenhagen, Michael J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Olivier, Stephen Lecler [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pedretti, Kevin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-10-01

    Measuring and controlling the power and energy consumption of high performance computing systems by various components in the software stack is an active research area [13, 3, 5, 10, 4, 21, 19, 16, 7, 17, 20, 18, 11, 1, 6, 14, 12]. Implementations in lower level software layers are beginning to emerge in some production systems, which is very welcome. To be most effective, a portable interface to measurement and control features would significantly facilitate participation by all levels of the software stack. We present a proposal for a standard power Application Programming Interface (API) that endeavors to cover the entire software space, from generic hardware interfaces to the input from the computer facility manager.

  13. Wheelchair Propulsion Biomechanics in Junior Basketball Players: A Method for the Evaluation of the Efficacy of a Specific Training Program.

    Science.gov (United States)

    Bergamini, Elena; Morelli, Francesca; Marchetti, Flavia; Vannozzi, Giuseppe; Polidori, Lorenzo; Paradisi, Francesco; Traballesi, Marco; Cappozzo, Aurelio; Delussu, Anna Sofia

    2015-01-01

    As participation in wheelchair sports increases, the need of quantitative assessment of biomechanical performance indicators and of sports- and population-specific training protocols has become central. The present study focuses on junior wheelchair basketball and aims at (i) proposing a method to identify biomechanical performance indicators of wheelchair propulsion using an instrumented in-field test and (ii) developing a training program specific for the considered population and assessing its efficacy using the proposed method. Twelve athletes (10 M, 2 F, age = 17.1 ± 2.7 years, years of practice = 4.5 ± 1.8) equipped with wheelchair- and wrist-mounted inertial sensors performed a 20-metre sprint test. Biomechanical parameters related to propulsion timing, progression force, and coordination were estimated from the measured accelerations and used in a regression model where the time to complete the test was set as dependent variable. Force- and coordination-related parameters accounted for 80% of the dependent variable variance. Based on these results, a training program was designed and administered for three months to six of the athletes (the others acting as control group). The biomechanical indicators proved to be effective in providing additional information about the wheelchair propulsion technique with respect to the final test outcome and demonstrated the efficacy of the developed program.

  14. Wheelchair Propulsion Biomechanics in Junior Basketball Players: A Method for the Evaluation of the Efficacy of a Specific Training Program

    Directory of Open Access Journals (Sweden)

    Elena Bergamini

    2015-01-01

    Full Text Available As participation in wheelchair sports increases, the need of quantitative assessment of biomechanical performance indicators and of sports- and population-specific training protocols has become central. The present study focuses on junior wheelchair basketball and aims at (i proposing a method to identify biomechanical performance indicators of wheelchair propulsion using an instrumented in-field test and (ii developing a training program specific for the considered population and assessing its efficacy using the proposed method. Twelve athletes (10 M, 2 F, age = 17.1 ± 2.7 years, years of practice = 4.5 ± 1.8 equipped with wheelchair- and wrist-mounted inertial sensors performed a 20-metre sprint test. Biomechanical parameters related to propulsion timing, progression force, and coordination were estimated from the measured accelerations and used in a regression model where the time to complete the test was set as dependent variable. Force- and coordination-related parameters accounted for 80% of the dependent variable variance. Based on these results, a training program was designed and administered for three months to six of the athletes (the others acting as control group. The biomechanical indicators proved to be effective in providing additional information about the wheelchair propulsion technique with respect to the final test outcome and demonstrated the efficacy of the developed program.

  15. Wheelchair Propulsion Biomechanics in Junior Basketball Players: A Method for the Evaluation of the Efficacy of a Specific Training Program

    Science.gov (United States)

    Bergamini, Elena; Morelli, Francesca; Marchetti, Flavia; Vannozzi, Giuseppe; Polidori, Lorenzo; Paradisi, Francesco; Traballesi, Marco; Cappozzo, Aurelio

    2015-01-01

    As participation in wheelchair sports increases, the need of quantitative assessment of biomechanical performance indicators and of sports- and population-specific training protocols has become central. The present study focuses on junior wheelchair basketball and aims at (i) proposing a method to identify biomechanical performance indicators of wheelchair propulsion using an instrumented in-field test and (ii) developing a training program specific for the considered population and assessing its efficacy using the proposed method. Twelve athletes (10 M, 2 F, age = 17.1 ± 2.7 years, years of practice = 4.5 ± 1.8) equipped with wheelchair- and wrist-mounted inertial sensors performed a 20-metre sprint test. Biomechanical parameters related to propulsion timing, progression force, and coordination were estimated from the measured accelerations and used in a regression model where the time to complete the test was set as dependent variable. Force- and coordination-related parameters accounted for 80% of the dependent variable variance. Based on these results, a training program was designed and administered for three months to six of the athletes (the others acting as control group). The biomechanical indicators proved to be effective in providing additional information about the wheelchair propulsion technique with respect to the final test outcome and demonstrated the efficacy of the developed program. PMID:26543852

  16. Cell-Type-Specific Gene Programs of the Normal Human Nephron Define Kidney Cancer Subtypes.

    Science.gov (United States)

    Lindgren, David; Eriksson, Pontus; Krawczyk, Krzysztof; Nilsson, Helén; Hansson, Jennifer; Veerla, Srinivas; Sjölund, Jonas; Höglund, Mattias; Johansson, Martin E; Axelson, Håkan

    2017-08-08

    Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue samples to serve as a transcriptional reference. In this study, we performed in-depth analyses of normal kidney tissue transcriptomes from the TCGA and demonstrate that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between samples. This should be considered when comparing expression profiles of normal and cancerous kidney tissues. We exploited these differences to define renal-cell-specific gene signatures and used these as a framework to analyze renal cell carcinoma (RCC) ontogeny. Chromophobe RCCs express FOXI1-driven genes that define collecting duct intercalated cells, whereas HNF-regulated genes, specific for proximal tubule cells, are an integral part of clear cell and papillary RCC transcriptomes. These networks may be used as a framework for understanding the interplay between genomic changes in RCC subtypes and the lineage-defining regulatory machinery of their non-neoplastic counterparts. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  17. Impact of public programs on fertility and gender specific investment in human capital of children in rural India: cross sectional and time series analyses.

    Science.gov (United States)

    Duraisamy, P; Malathy, R

    1991-01-01

    Cross sectional and time series analyses are conducted with 1971 and 1981 rural district level data for India in order to estimate variations in program impacts on household decisionmaking concerning fertility, child mortality, and schooling; to analyze how the variation in public program subsidies and services influences sex specific investments in schooling; and to examine the bias in cross sectional estimates by employing fixed effects methodology. The theory of household production uses the framework development by Rosenzweig and Wolpin. The utility function is expressed as a function of families' desired number of children, sex specific investment in human capital of children measured by schooling of males and females, and a composite consumption good. Budget constraints are characterized in terms of the biological supply of births or natural fertility, the number of births averted by fertility control, exogenous money income, the prices of number of children, contraceptives, child schooling, and consumption of goods. Demand functions are constructed from maximizing the utility function subject to the budget constraint. Data constitute 40% of the total districts and 50% of the rural population. The empirical specification of the linear model and variable description are provided. Other explanatory variables included are adult educational attainment; % of scheduled castes and tribes and % Muslim; and % rural population. Estimation methods are described and justification is provided for the use of ordinary least squares and fixed effects methods. The results of the cross sectional analysis reveal that own-program effects of family planning and primary health centers reduced family size in 1971 and 81. The increase in secondary school enrollment is evidenced in only 1971. There is a significant effect of family planning (FP) clinics on the demand for surviving children only in 1971. The presence of a seconary school in a village reduces the demand for children in

  18. Mental Health of Adults Treated in Adolescence with Scoliosis-Specific Exercise Program or Observed for Idiopathic Scoliosis

    Directory of Open Access Journals (Sweden)

    Maciej Płaszewski

    2014-01-01

    Full Text Available Objective. To examine general mental health in adult males and females, who in adolescence participated in a scoliosis-specific therapeutic exercise program or were under observation due to diagnosis of scoliosis. Design. Registry-based, cross-sectional study with retrospective data collection. Methods. Sixty-eight subjects (43 women aged 30.10 (25–39 years, with mild or moderate scoliosis (11–36° Cobb angle, and 76 (38 women nonscoliotic subjects, aged 30.11 (24–38 years, participated. The time period since the end of the exercise or observation regimes was 16.5 (12-26 years. Beck Depression Inventory (BDI and General Health Questionnaire (GHQ-28 scores were analyzed with the χ2 and U tests. Multiple regression analyses for confounders were also performed. Results. Intergroup differences of demographic characteristics were nonsignificant. Scoliosis, gender, participation in the exercise program, employment, and marital status were associated with BDI scores. The presence of scoliosis and participation in the exercise program manifested association with the symptoms. Higher GHQ-28 “somatic symptoms” subscale scores interacted with the education level. Conclusions. Our findings correspond to the reports of a negative impact of the diagnosis of scoliosis and treatment on mental health. The decision to introduce a therapeutic program in children with mild deformities should be made with judgment of potential benefits, risks, and harm.

  19. Establishing an optimized patient-specific verification program for volumetric modulated arc therapy

    Energy Technology Data Exchange (ETDEWEB)

    Serna, Alfredo, E-mail: alfredo.serna@carm.es [Department of Medical Physics, Hospital Universitario Santa Lucía, Cartagena (Spain); Mata, Fernando; Puchades, Vicente [Department of Medical Physics, Hospital Universitario Santa Lucía, Cartagena (Spain)

    2013-10-01

    Quality assurance (QA) of volumetric modulated arc therapy (VMAT) increases the workload significantly. We compared the results from 4 verification methods to establish an efficient VMAT QA. Planning for VMAT treatments was carried out for 40 consecutive patients. Pretreatment verifications were carried out with ion chamber array Physikalish-Technische Werkstätten (PTW729), electronic portal dosimetry (EPID), ion chamber measurements, and independent dose calculation with Diamond program. 2D analyses were made using the gamma analysis (3 mm distance to agreement and 3% dose difference relative to maximum, 10% dose threshold). Average point dose difference calculated by Eclipse relative to ion chamber measurements and Diamond were 0.1%±0.9% and 0.6%±2.2%, respectively. Average pass rate for PTW729 was 99.2%±1.9% and 98.3%±1.3% for EPID. The total required time (linac occupancy time given in parentheses) for each QA method was: PTW729 43.5 minutes (26.5 minutes), EPID 14.5 minutes (2.5 minutes), ion chamber 34.5 minutes (26.5 minutes), and Diamond 12.0 minutes (0 minute). The results were consistent and allowed us to establish an optimized protocol, considering safety and accuracy as well as workload, consisting of 2 verification methods: EPID 2D analysis and independent dose calculation.

  20. Programming Pluripotent Precursor Cells Derived from Xenopus Embryos to Generate Specific Tissues and Organs

    Directory of Open Access Journals (Sweden)

    Annette Borchers

    2010-11-01

    Full Text Available Xenopus embryos provide a rich source of pluripotent cells that can be differentiated into functional organs. Since the molecular principles of vertebrate organogenesis appear to be conserved between Xenopus and mammals, this system can provide useful guidelines for the directional manipulation of human embryonic stem cells. Pluripotent Xenopus cells can be easily isolated from the animal pole of blastula stage Xenopus embryos. These so called “animal cap” cells represent prospective ectodermal cells, but give rise to endodermal, mesodermal and neuro-ectodermal derivatives if treated with the appropriate factors. These factors include evolutionary conserved modulators of the key developmental signal transduction pathways that can be supplied either by mRNA microinjection or direct application of recombinant proteins. This relatively simple system has added to our understanding of pancreas, liver, kidney, eye and heart development. In particular, recent studies have used animal cap cells to generate ectopic eyes and hearts, setting the stage for future work aimed at programming pluripotent cells for regenerative medicine.

  1. The Cost of Crime to Society: New Crime-Specific Estimates for Policy and Program Evaluation

    Science.gov (United States)

    French, Michael T.; Fang, Hai

    2010-01-01

    Estimating the cost to society of individual crimes is essential to the economic evaluation of many social programs, such as substance abuse treatment and community policing. A review of the crime-costing literature reveals multiple sources, including published articles and government reports, which collectively represent the alternative approaches for estimating the economic losses associated with criminal activity. Many of these sources are based upon data that are more than ten years old, indicating a need for updated figures. This study presents a comprehensive methodology for calculating the cost of society of various criminal acts. Tangible and intangible losses are estimated using the most current data available. The selected approach, which incorporates both the cost-of-illness and the jury compensation methods, yields cost estimates for more than a dozen major crime categories, including several categories not found in previous studies. Updated crime cost estimates can help government agencies and other organizations execute more prudent policy evaluations, particularly benefit-cost analyses of substance abuse treatment or other interventions that reduce crime. PMID:20071107

  2. High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring.

    Science.gov (United States)

    Tain, You-Lin; Lin, Yu-Ju; Sheen, Jiunn-Ming; Yu, Hong-Ren; Tiao, Mao-Meng; Chen, Chih-Cheng; Tsai, Ching-Chou; Huang, Li-Tung; Hsu, Chien-Ning

    2017-04-03

    Obesity and related disorders have increased concurrently with an increased consumption of saturated fatty acids. We examined whether post-weaning high fat (HF) diet would exacerbate offspring vulnerability to maternal HF-induced programmed hypertension and kidney disease sex-specifically, with a focus on the kidney. Next, we aimed to elucidate the gene-diet interactions that contribute to maternal HF-induced renal programming using the next generation RNA sequencing (NGS) technology. Female Sprague-Dawley rats received either a normal diet (ND) or HF diet (D12331, Research Diets) for five weeks before the delivery. The offspring of both sexes were put on either the ND or HF diet from weaning to six months of age, resulting in four groups of each sex (maternal diet/post-weaning diet; n = 5-7/group): ND/ND, ND/HF, HF/ND, and HF/HF. Post-weaning HF diet increased bodyweights of both ND/HF and HF/HF animals from three to six months only in males. Post-weaning HF diet increased systolic blood pressure in male and female offspring, irrespective of whether they were exposed to maternal HF or not. Male HF/HF offspring showed greater degrees of glomerular and tubular injury compared to the ND/ND group. Our NGS data showed that maternal HF diet significantly altered renal transcriptome with female offspring being more HF-sensitive. HF diet induced hypertension and renal injury are associated with oxidative stress, activation of renin-angiotensin system, and dysregulated sodium transporters and circadian clock. Post-weaning HF diet sex-specifically exacerbates the development of obesity, kidney injury, but not hypertension programmed by maternal HF intake. Better understanding of the sex-dependent mechanisms that underlie HF-induced renal programming will help develop a novel personalized dietary intervention to prevent obesity and related disorders.

  3. [Specifics of cognitive behavioral therapy in schizophrenia. Integrated program of psychological therapy].

    Science.gov (United States)

    Konen, A; Neis, L; Hodel, B; Brenner, H D

    1993-01-01

    According to the authors, information processing disorders contribute essentially to the vulnerability of the schizophrenic patient. Attentional/perceptual and cognitive disorders exert a pervasive influence on more complex levels of overt behavior in schizophrenia. Conversely, behavioral deficits influence cognitive functioning as well. Psychosocial rehabilitation of patients with schizophrenia must therefore address the impact of disordered attentional/perceptual and conceptual processes and their integrating organization on behavior as well as the effects of behavioral dysfunctions on cognition. The Integrated Psychological Treatment Program (IPT) for schizophrenic patients provides means of addressing these interactions. The designation "integrated" implies that the treatment is directed at cognitive disorders as well as behavioral/social deficits by using highly structured interventions, and is carried out with "reality-oriented" material. This treatment approach has been developed by Brenner and al., since 1976. The original IPT includes five subprograms: Cognitive Differentiation, Social Perception, Verbal Communication, Social Skills and Interpersonal Problem Solving. Patients first work on improving disordered basic cognitive functions in the Cognitive Differentiation subprogram. Exercises are directed at impairments in attentional/perceptual and conceptual processes. Mastery of this subprogram leads to the Social Perception subprogram, which aims at disturbances in processes of stimulus discrimination and interpretation on perceiving and assessing social interactions. The Verbal Communication subprogram follows successful completion of the previous subprograms and trains associative-semantic processes as well as basic skills necessary for conversation. In the Social Skills subprogram, interpersonal behaviors and self-instructions required for gaining instrumental and emotional aims are taught.(ABSTRACT TRUNCATED AT 250 WORDS)

  4. SP-Designer: a user-friendly program for designing species-specific primer pairs from DNA sequence alignments.

    Science.gov (United States)

    Villard, Pierre; Malausa, Thibaut

    2013-07-01

    SP-Designer is an open-source program providing a user-friendly tool for the design of specific PCR primer pairs from a DNA sequence alignment containing sequences from various taxa. SP-Designer selects PCR primer pairs for the amplification of DNA from a target species on the basis of several criteria: (i) primer specificity, as assessed by interspecific sequence polymorphism in the annealing regions, (ii) the biochemical characteristics of the primers and (iii) the intended PCR conditions. SP-Designer generates tables, detailing the primer pair and PCR characteristics, and a FASTA file locating the primer sequences in the original sequence alignment. SP-Designer is Windows-compatible and freely available from http://www2.sophia.inra.fr/urih/sophia_mart/sp_designer/info_sp_designer.php. © 2013 John Wiley & Sons Ltd.

  5. Positional Concerns and Institutions

    DEFF Research Database (Denmark)

    Landes, Xavier

    2013-01-01

    their implications for economics, positional concerns imply important normative dimensions. There have been presumed to be a symptom of envy, reduce people’s happiness, and create problems of social interaction or economic inefficiencies. Individuals are, for instance, prone to pick states of the world that improve...... that invoking envy or subjective well-being is not fully satisfying for regulating positional concerns. More compelling reasons seem, in complement with efficiency, to be related to considerations for equality. In other words, if institutions could have strong reasons to pay attention to and regulate positional...... concerns, it would be in virtue of their impact on the social product and individuals’ conditions of living....

  6. Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers.

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available BACKGROUND: Inadequate oxygen (hypoxia triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible factor (HIF, plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia among different cell types or how this variation might relate to tissue- and cell-specific diseases. METHODS AND FINDINGS: We analyzed the temporal changes in global transcript levels in response to hypoxia in primary renal proximal tubule epithelial cells, breast epithelial cells, smooth muscle cells, and endothelial cells with DNA microarrays. The extent of the transcriptional response to hypoxia was greatest in the renal tubule cells. This heightened response was associated with a uniquely high level of HIF-1alpha RNA in renal cells, and it could be diminished by reducing HIF-1alpha expression via RNA interference. A gene-expression signature of the hypoxia response, derived from our studies of cultured mammary and renal tubular epithelial cells, showed coordinated variation in several human cancers, and was a strong predictor of clinical outcomes in breast and ovarian cancers. In an analysis of a large, published gene-expression dataset from breast cancers, we found that the prognostic information in the hypoxia signature was virtually independent of that provided by the previously reported wound signature and more predictive of outcomes than any of the clinical parameters in current use. CONCLUSIONS: The transcriptional response to hypoxia varies among human cells. Some of this variation is traceable to variation in expression of the HIF1A gene. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis

  7. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.

    Directory of Open Access Journals (Sweden)

    Jen-Tsan Chi

    2006-03-01

    Full Text Available Inadequate oxygen (hypoxia triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible factor (HIF, plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein. Despite the ubiquity and importance of hypoxia responses, little is known about the variation in the global transcriptional response to hypoxia among different cell types or how this variation might relate to tissue- and cell-specific diseases.We analyzed the temporal changes in global transcript levels in response to hypoxia in primary renal proximal tubule epithelial cells, breast epithelial cells, smooth muscle cells, and endothelial cells with DNA microarrays. The extent of the transcriptional response to hypoxia was greatest in the renal tubule cells. This heightened response was associated with a uniquely high level of HIF-1alpha RNA in renal cells, and it could be diminished by reducing HIF-1alpha expression via RNA interference. A gene-expression signature of the hypoxia response, derived from our studies of cultured mammary and renal tubular epithelial cells, showed coordinated variation in several human cancers, and was a strong predictor of clinical outcomes in breast and ovarian cancers. In an analysis of a large, published gene-expression dataset from breast cancers, we found that the prognostic information in the hypoxia signature was virtually independent of that provided by the previously reported wound signature and more predictive of outcomes than any of the clinical parameters in current use.The transcriptional response to hypoxia varies among human cells. Some of this variation is traceable to variation in expression of the HIF1A gene. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and ovarian cancer.

  8. LGBT Caregiver Concerns

    Science.gov (United States)

    LGBT CAREGIVER CONCERNS IMPORTANT CONSIDERATIONS FOR LGBT CAREGIVERS LGBT CAREGIVER CONSIDERATIONS As a caregiver for someone with Alzheimer’s disease, you will face various challenges. Some are common among all ...

  9. Hydrologic Areas of Concern

    Data.gov (United States)

    University of New Hampshire — A Hydrologic Area of Concern (HAC) is a land area surrounding a water source, which is intended to include the portion of the watershed in which land uses are likely...

  10. Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection.

    Science.gov (United States)

    Abboud, Georges; Desai, Pritesh; Dastmalchi, Farhad; Stanfield, Jessica; Tahiliani, Vikas; Hutchinson, Tarun E; Salek-Ardakani, Shahram

    2016-12-12

    How tissue-specific anatomical distribution and phenotypic specialization are linked to protective efficacy of memory T cells against reinfection is unclear. Here, we show that lung environmental cues program recently recruited central-like memory cells with migratory potentials for their tissue-specific functions during lethal respiratory virus infection. After entering the lung, some central-like cells retain their original CD27hiCXCR3hi phenotype, enabling them to localize near the infected bronchiolar epithelium and airway lumen to function as the first line of defense against pathogen encounter. Others, in response to local cytokine triggers, undergo a secondary program of differentiation that leads to the loss of CXCR3, migration arrest, and clustering within peribronchoarterial areas and in interalveolar septa. Here, the immune system adapts its response to prevent systemic viral dissemination and mortality. These results reveal the striking and unexpected spatial organization of central- versus effector-like memory cells within the lung and how cooperation between these two subsets contributes to host defense. © 2016 Abboud et al.

  11. An evaluation study of a gender-specific smoking cessation program to help Hong Kong Chinese women quit smoking.

    Science.gov (United States)

    Li, Ho Cheung William; Chan, Sophia Siu Chee; Wan, Zoe Siu Fung; Wang, Man Ping; Lam, Tai Hing

    2015-09-29

    There is a lack of population-based smoking cessation interventions targeting woman smokers in Hong Kong, and in Asia generally. This study aimed to evaluate the effectiveness of a gender-specific smoking cessation program for female smokers in Hong Kong. To evaluate the effectiveness of the service, a total of 457 eligible smokers were recruited. After the baseline questionnaire had been completed, a cessation counseling intervention was given by a trained counselor according to the stage of readiness to quit. Self-reported seven-day point prevalence of abstinence and reduction of cigarette consumption (≥50 %) and self-efficacy in rejecting tobacco were documented at one week and at two, three and six months. The 7-day point prevalence quit rate was 28.4 % (130/457), and 21.9 % (100/457) had reduced their cigarette consumption by at least 50 % at the six-month follow-up. The average daily cigarette consumption was reduced from 8.3 at baseline to 6.3 at six months. Moreover, both internal and external stimuli of anti-smoking self-efficacy increased from baseline to six months. The study provides some evidence for the effectiveness of the gender-specific smoking cessation program for female smokers. Furthermore, helping smokers to improve their self-efficacy in resisting both internal and external stimuli of tobacco use can be a way of enhancing the effectiveness of a smoking cessation intervention.

  12. Consolidated guidance about materials licenses: Program-specific guidance about portable gauge licenses. Final report; Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Vacca, P.C.; Whitten, J.E.; Pelchat, J.M.; Arredondo, S.A.; Matson, E.R.; Lewis, S.H.; Collins, D.J.; Santiago, P.A. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Industrial and Medical Nuclear Safety; Tingle, W. [Dept. of Environment, Health, and Natural Resources, Raleigh, NC (United States). Div. of Radiation Protection

    1997-05-01

    As part of its redesign of the materials licensing process, NRC is consolidating and updating numerous guidance documents into a single comprehensive repository as described in NUREG-1539 and draft NUREG-1541. NUREG-1556, Vol. 1, is the first program-specific guidance developed for the new process and will serve as a template for subsequent program-specific guidance. This document is intended for use by applicants, licensees, and NRC staff and will also be available to Agreement States. This document supersedes the guidance previously found in draft Regulatory Guide DG-0008, ``Applications for the Use of Sealed Sources in Portable Gauging Devices,`` and in NMSs Policy and guidance Directive 2-07, ``Standard Review Plan for Applications for Use of Sealed Sources in Portable Gauging Devices.`` This final report takes a more risk-informed, performance-based approach to licensing portable gauges, and reduces the information(amount and level of detail) needed to support an application to use these devices. It incorporates many suggests submitted during the comment period on draft NUREG-1556, Volume 1. When published, this final report should be used in preparing portable gauge license applications. NRC staff will use this final report in reviewing these applications.

  13. Influence on Strength and Flexibility of a Swing Phase-Specific Hamstring Eccentric Program in Sprinters' General Preparation.

    Science.gov (United States)

    Guex, Kenny J; Lugrin, Véronique; Borloz, Stéphane; Millet, Grégoire P

    2016-02-01

    Hamstring injuries are common in sprinters and mainly occur during the terminal swing phase. Eccentric training has been shown to reduce hamstring injury rate by improving several risk factors. The aim of this study was to test the hypothesis that an additional swing phase-specific hamstring eccentric training in well-trained sprinters performed at the commencement of the winter preparation is more efficient to improve strength, ratio, optimum angle, and flexibility than a similar program without hamstring eccentric exercises. Twenty sprinters were randomly allocated to an eccentric (n = 10) or a control group (n = 10). Both groups performed their usual track and field training throughout the study period. Sprinters in the eccentric group performed an additional 6-week hamstring eccentric program, which was specific to the swing phase of the running cycle (eccentric high-load open-chain kinetic movements covering the whole hamstring length-tension relationship preformed at slow to moderate velocity). Isokinetic and flexibility measurements were performed before and after the intervention. The eccentric group increased hamstring peak torques in concentric at 60° · s(-1) by 16% (p training in sprinters seems to be crucial to address different risk factors for hamstring strain injuries, such as eccentric and concentric strength, hamstring-to-quadriceps ratio ratio, and flexibility.

  14. CAN A SPECIFIC NECK STRENGTHENING PROGRAM DECREASE CERVICAL SPINE INJURIES IN A MEN'S PROFESSIONAL RUGBY UNION TEAM? A RETROSPECTIVE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Robert Naish

    2013-09-01

    Full Text Available Cervical spine injuries in Rugby Union are a concerning issue at all levels of the game. The primary aim of this retrospective analysis conducted in a professional Rugby Union squad was to determine whether a 26-week isometric neck strengthening intervention program (13-week strengthening phase and 13-week maintenance phase was effective in reducing the number and severity of cervical spine injuries. The secondary aim was to determine whether at week five, where the program had been the similar for all players, there was increased isometric neck strength. All 27 players who were common to both the 2007-2008 and 2008-2009 seasons were included in this analysis and data was extracted from a Sports Medicine/Sports Science database which included the squad's injury records. Primary outcome variables included; the number of cervical spine injuries and the severity of these injuries as determined by the total number of days lost from training and competition. Secondary outcome variables included isometric neck strength in flexion, extension and left and right lateral flexion. Using non-parametric statistical methods, no significant differences were evident for the total number of cervical spine injuries (n = 8 in 2007-2008, n = 6 in 2008-2009 or time loss due to these injuries (100 days in 2007-2008, 40 days in 2008-2009. However, a significant (p = 0.03 reduction in the number of match injuries was evident from 2007-2008 (n = 11 to 2008-09 (n = 2. Non-significant increases in isometric neck strength were found in all directions examined. A significant reduction in the number of match injuries was evident in this study. However, no other significant changes to primary outcome variables were achieved. Further, no significant increases in isometric neck strength were found in this well-trained group of professional athletes

  15. Identification of H-Ras-Specific Motif for the Activation of Invasive Signaling Program in Human Breast Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Hae-Young Yong

    2011-02-01

    Full Text Available Increased expression and/or activation of H-Ras are often associated with tumor aggressiveness in breast cancer. Previously, we showed that H-Ras, but not N-Ras, induces MCF10A human breast epithelial cell invasion and migration, whereas both H-Ras and N-Ras induce cell proliferation and phenotypic transformation. In an attempt to determine the sequence requirement directing the divergent phenotype induced by H-Ras and N-Ras with a focus on the induction of human breast cell invasion, we investigated the structural and functional relationships between H-Ras and N-Ras using domain-swap and site-directed mutagenesis approaches. Here, we report that the hypervariable region (HVR, consisting of amino acids 166 to 189 in H-Ras, determines the invasive/migratory signaling program as shown by the exchange of invasive phenotype by swapping HVR sequences between H-Ras and N-Ras. We also demonstrate that the H-Ras-specific additional palmitoylation site at Cys184 is not responsible for the signaling events that distinguish between H-Ras and N-Ras. Importantly, this work identifies the C-terminal HVR, especially the flexible linker domain with two consecutive proline residues Pro173 and Pro174, as a critical domain that contributes to activation of H-Ras and its invasive potential in human breast epithelial cells. The present study sheds light on the structural basis for the Ras isoform-specific invasive program of breast epithelial cells, providing information for the development of agents that specifically target invasion-related H-Ras pathways in human cancer.

  16. Fairness and nanotechnology concern.

    Science.gov (United States)

    McComas, Katherine A; Besley, John C

    2011-11-01

    Research suggests that fairness perceptions matter to people who are asked to evaluate the acceptability of risks or risk management. Two separate national random surveys (n = 305 and n = 529) addressed Americans' concerns about and acceptance of nanotechnology risk management in the context of the degree to which they view scientists and risk managers as fair. The first survey investigated general views about scientists across four proposed dimensions of fairness (distributional, procedural, interpersonal, and informational). The results show that respondents who believe that the outcomes of scientific research tend to result in unequal benefits (distributional fairness) and that the procedures meant to protect the public from scientific research are biased (procedural fairness) were more concerned about nanotechnology. Believing scientists would treat them with respect (interpersonal fairness) and ensure access to information (informational fairness) were not significant predictors of concern. The second study also looked at these four dimensions of fairness but focused on perceptions of risk managers working for government, universities, and major companies. In addition to concern, it also examined acceptance of nanotechnology risk management. Study 2 results were similar to those of study 1 for concern; however, only perceived informational fairness consistently predicted acceptance of nanotechnology risk management. Overall, the study points to the value of considering fairness perceptions in the study of public perceptions of nanotechnology. © 2011 Society for Risk Analysis.

  17. Postural instability of extremely obese individuals improves after a body weight reduction program entailing specific balance training.

    Science.gov (United States)

    Maffiuletti, N A; Agosti, F; Proietti, M; Riva, D; Resnik, M; Lafortuna, C L; Sartorio, A

    2005-01-01

    The purposes of this study were to compare postural stability between obese and lean subjects and to investigate the effect of a 3-week body weight reduction (BWR) program entailing specific balance training on postural stability of extremely obese patients. Time of balance maintenance and mean error on the medial-lateral direction at the trunk and lower limb level were assessed during a single limb stance on a movable platform in 19 non-obese and in 20 extremely obese individuals (age range: 20-40 yr). Time of balance maintenance was shorter (obese: 21.1+/-7.7 vs lean: 27.3+/-3.1 sec) and medial-lateral sway of the trunk was larger in obese (5.4+/-3.2 degrees) than in lean (3.2+/-1.1 degrees) subjects (pprogram (energy-restricted diet, moderate physical exercise, nutritional education and psychological counselling) combined with or without 6 sessions of specific balance training on a movable platform. BWR plus specific balance training enhanced time of balance maintenance (pre: 23.8+/-7.2 vs post: 30.0+/-0.0 sec) and reduced the trunk sway (5.2+/-2.8 degrees vs 2.6+/-0.9 degrees ) more than BWR alone (pprogram. It was concluded that balance improvement is an important goal of rehabilitation, that would probably reduce the propensity of overweight individuals to fall while performing everyday activities.

  18. The effects of a four-semester pre-service secondary teacher education program on the perceptions and practices of pre-service science teachers concerning constructivist perspectives to teaching

    Science.gov (United States)

    Masene, Robert Sinvula

    This is an exploratory study that examines: (a) changes in pre-service teachers philosophical and pedagogical conceptions concerning teaching and learning, (b) changes in pre-service teachers' perceptions concerning the instruction they received in their methods courses, and (c) the relationships among pre-service teachers pedagogical and philosophical conceptions, perceptions about the methods course instruction and their own instructional practices, and their actual instructional practices as revealed on videotapes over a four-semester sequence. A sample of thirty-six pre-service teachers (18 males and 18 females) from the Iowa-SSTEP four-semester sequence volunteered to participate in the study. Three instruments were used to generate the main data to answer the research questions. The three instruments were: (a) Teachers Pedagogical and Philosophical Interview (TPPI), (b) Constructivist Learning Environment Survey (CLES), and (c) videotape portfolio evaluated with the Expert Science Teaching Evaluation Model (ESTEEM). Major results include the following: (1) As pre-service teachers enrolled in a four-semester sequence progressed through the teacher education program, their conceptions concerning teaching and learning became significantly and increasingly more student-centered in terms of what students need to do to enhance their understanding of science concepts and processes as well as in their espoused philosophies of teaching and learning. (2) Pre-service teachers integrated their newly acquired student-centered conceptions from their methods courses, with their previous teacher-centered conceptions to develop mixed conceptions about teaching and learning. (3) Pre-service teachers' espoused conceptions and their perceptions about classroom practices rarely align observed teaching practices in their classroom. (4) Pre-service teacher cohort level in the Iowa-SSTEP sequence proved to have a positive and significant effect on pre-service teachers

  19. Empathic concern drives costly altruism.

    Science.gov (United States)

    FeldmanHall, Oriel; Dalgleish, Tim; Evans, Davy; Mobbs, Dean

    2015-01-15

    Why do we self-sacrifice to help others in distress? Two competing theories have emerged, one suggesting that prosocial behavior is primarily motivated by feelings of empathic other-oriented concern, the other that we help mainly because we are egoistically focused on reducing our own discomfort. Here we explore the relationship between costly altruism and these two sub-processes of empathy, specifically drawing on the caregiving model to test the theory that trait empathic concern (e.g. general tendency to have sympathy for another) and trait personal distress (e.g. predisposition to experiencing aversive arousal states) may differentially drive altruistic behavior. We find that trait empathic concern--and not trait personal distress--motivates costly altruism, and this relationship is supported by activity in the ventral tegmental area, caudate and subgenual anterior cingulate, key regions for promoting social attachment and caregiving. Together, this data helps identify the behavioral and neural mechanisms motivating costly altruism, while demonstrating that individual differences in empathic concern-related brain responses can predict real prosocial choice. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Empathic concern drives costly altruism

    Science.gov (United States)

    FeldmanHall, Oriel; Dalgleish, Tim; Evans, Davy; Mobbs, Dean

    2015-01-01

    Why do we self-sacrifice to help others in distress? Two competing theories have emerged, one suggesting that prosocial behavior is primarily motivated by feelings of empathic other-oriented concern, the other that we help mainly because we are egoistically focused on reducing our own discomfort. Here we explore the relationship between costly altruism and these two sub-processes of empathy, specifically drawing on the caregiving model to test the theory that trait empathic concern (e.g. general tendency to have sympathy for another) and trait personal distress (e.g. predisposition to experiencing aversive arousal states) may differentially drive altruistic behavior. We find that trait empathic concern – and not trait personal distress – motivates costly altruism, and this relationship is supported by activity in the ventral tegmental area, caudate and subgenual anterior cingulate, key regions for promoting social attachment and caregiving. Together, this data helps identify the behavioral and neural mechanisms motivating costly altruism, while demonstrating that individual differences in empathic concern-related brain responses can predict real prosocial choice. PMID:25462694

  1. Cost and Impact of Voluntary Medical Male Circumcision in South Africa: Focusing the Program on Specific Age Groups and Provinces.

    Directory of Open Access Journals (Sweden)

    Katharine Kripke

    Full Text Available In 2012, South Africa set a goal of circumcising 4.3 million men ages 15-49 by 2016. By the end of March 2014, 1.9 million men had received voluntary medical male circumcision (VMMC. In an effort to accelerate progress, South Africa undertook a modeling exercise to determine whether circumcising specific client age groups or geographic locations would be particularly impactful or cost-effective. Results will inform South Africa's efforts to develop a national strategy and operational plan for VMMC.The study team populated the Decision Makers' Program Planning Tool, Version 2.0 (DMPPT 2.0 with HIV incidence projections from the Spectrum/AIDS Impact Module (AIM, as well as national and provincial population and HIV prevalence estimates. We derived baseline circumcision rates from the 2012 South African National HIV Prevalence, Incidence and Behaviour Survey. The model showed that circumcising men ages 20-34 offers the most immediate impact on HIV incidence and requires the fewest circumcisions per HIV infection averted. The greatest impact over a 15-year period is achieved by circumcising men ages 15-24. When the model assumes a unit cost increase with client age, men ages 15-29 emerge as the most cost-effective group. When we assume a constant cost for all ages, the most cost-effective age range is 15-34 years. Geographically, the program is cost saving in all provinces; differences in the VMMC program's cost-effectiveness across provinces were obscured by uncertainty in HIV incidence projections.The VMMC program's impact and cost-effectiveness vary by age-targeting strategy. A strategy focusing on men ages 15-34 will maximize program benefits. However, because clients older than 25 access VMMC services at low rates, South Africa could consider promoting demand among men ages 25-34, without denying services to those in other age groups. Uncertainty in the provincial estimates makes them insufficient to support geographic targeting.

  2. Traumatic brain injury rehabilitation, the programs applied in French UEROS units, and the specificity of the Limoges experience.

    Science.gov (United States)

    Hamonet-Torny, J; Fayol, P; Faure, P; Carrière, H; Dumond, J-J

    2013-04-01

    First created in 1996, the French evaluation, retraining, social and vocational orientation units (UEROS) now play a fundamental role in the social and vocational rehabilitation of patients with brain injury. As of today, there exist 30 UEROS centers in France. While their care and treatment objectives are shared, their means of assessment and retraining differ according to the experience of each one. The objective of this article is to describe the specific programs and the different tools put to work in the UEROS of Limoges. The UEROS of Limoges would appear to offer a form of holistic rehabilitation management characterized by the importance of psycho-education and its type of approach towards vocational reintegration. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  3. Near Term Hybrid Passenger Vehicle Development Program. Phase I, Final report. Appendix A: mission analysis and performance specification studies. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    Traversi, M.; Barbarek, L.A.C.

    1979-04-20

    Studies are described which were performed for the Near Term Hybrid Vehicle program to determine passenger car usage patterns and to correlate these trip mission characteristics with vehicle design and performance specifications. (LCL)

  4. Tagged vulture causes concerns

    African Journals Online (AJOL)

    2008-09-15

    Sep 15, 2008 ... student from the Department of Ecology,. Evolution and. Behaviour at the. Tagged vulture causes concerns. Hebrew University of Jerusalem, working under Professor Ran Nathan and studying the movement and ... in a proliferation of feral dogs, wolves and particularly Golden Jackals (which are extremely ...

  5. Integration of complementary and alternative medicine into cancer-specific supportive care programs in Australia: A scoping study.

    Science.gov (United States)

    Lim, Eunjin; Vardy, Janette L; Oh, Byeongsang; Dhillon, Haryana M

    2017-02-01

    The main aim of this research was to describe the availability and integration of supportive care programs (SCPs), particularly complementary and alternative medicine (CAM) services, for adults in Australian oncology treatment centers. We systematically searched 124 Australian hospitals listed as having an oncology department out of a total of 1157 hospitals listed in the Australian Hospitals and Aged Care Databases (2014), and assessed their website and relevant leaflets. Direct contact was made with a relevant staff member in each hospital. Data were collected regarding the range of SCP and CAM services available. Of the 124 hospitals, 89 (72%) provide nonspecific guidance to SCP or a staff member (e.g. social worker or care coordinator) who directs patients, advising them about SCP; 35 hospitals (28%) provide active referral to SCP, of which 24 of 35 (69%) include CAM in their service, with individual variation in how it is incorporated. Only 11 (46%) of these 24 CAM incorporated oncology centers in Australia provided systematically integrated CAM programs. The majority of Australian oncology departments do not have CAM incorporated into their services. In those that do, less than half had systemically integrated CAM. The types of CAM available, how they are accessed and how they are integrated varied across hospitals. Further research is required to understand how to successfully and systematically integrate cancer-specific supportive care such as CAM into Australian cancer services. © 2016 John Wiley & Sons Australia, Ltd.

  6. The Sensitivity, Specificity and Predictive Values of Snellen Chart Compared to the Diagnostic Test in Amblyopia Screening Program in Iran

    Directory of Open Access Journals (Sweden)

    Fatemeh Rivakani

    2015-12-01

    Full Text Available Introduction Amblyopia is a leading cause of visual impairment in both childhood and adult populations. Our aim in this study was to assess the epidemiological characteristics of the amblyopia screening program in Iran. Materials and Methods A cross-sectional study was done on a randomly selected sample of 4,636 Iranian children who were referred to screening program in 2013 were participated in validity study, too. From each provinces the major city were selected. Screening and diagnostic tests were done by instructors in first stage and optometrists in second stage, respectively. Finally data were analyzed by Stata version 13. Results The sensitivity was ranged from 74% to 100% among the various provinces such that Fars and Ardabil province had maximum and minimum values, respectively. The pattern of specificity was differ and ranged 44% to 84% among the provinces; Hormozgan and Fars had maximum and minimum values, respectively. The positive predictive value was also ranged from 35% to %81 which was assigned to Khuzestan and Ardabil provinces, respectively. The range of Negative Predictive value was 61% to 100% which was belonged to Ardabil and Fars provinces. Conclusion The total sensitivity (89% and negative predictive values (93% of screening test among children aged 3-6 years is acceptable, but only 51% of children refereed to second stage are true positive and this imposes considerable cost to health system.

  7. "It runs in the family": intergenerational transmission of historical trauma among urban American Indians and Alaska Natives in culturally specific sobriety maintenance programs.

    Science.gov (United States)

    Myhra, Laurelle L

    2011-01-01

    The aim of this exploratory study, which was informed by ethnographic principles, was to better understand the intergenerational transmission of historical trauma among urban American Indians/Alaska Natives (AI/ANs) in culturally specific sobriety maintenance programs. The results of the study were organized into 3 overarching categories, which included 10 themes that emerged contextually in relation to participants' lived experience of historical and associated traumas, substance abuse, and current involvement in a culturally specific sobriety maintenance program.

  8. Implementing an Audience-Specific Small-Group Gatekeeper Training Program to Respond to Suicide Risk among College Students: A Case Study

    Science.gov (United States)

    Cimini, M. Dolores; Rivero, Estela M.; Bernier, Joseph E.; Stanley, Judith A.; Murray, Andrea D.; Anderson, Drew A.; Wright, Heidi R.; Bapat, Mona

    2014-01-01

    Objective: This case study evaluated the effectiveness of an audience-specific, single-session, small-group interactive gatekeeper training program conducted at a large northeastern public university. Participants: Participants were 335 faculty, staff, and students completing gatekeeper training programs tailored to their group needs. Methods:…

  9. The short-term effects of a body awareness program : better self-management of health problems for individuals with chronic a-specific psychosomatic symptoms

    NARCIS (Netherlands)

    Landsman-Dijkstra, Jeanet J. A.; van Wijck, R; Groothoff, JW; Rispens, P

    2004-01-01

    A three-day residential Body Awareness Program (BAP) was developed to teach people with Chronic A-specific Psychosomatic Symptoms (CAPS) to react adequately to disturbances of the balance between a daily workload and the capacity to deal with it. The short-term effects of the program for people with

  10. Expression profiling of the wheat pathogen Zymoseptoria tritici reveals genomic patterns of transcription and host-specific regulatory programs.

    Science.gov (United States)

    Kellner, Ronny; Bhattacharyya, Amitava; Poppe, Stephan; Hsu, Tiffany Y; Brem, Rachel B; Stukenbrock, Eva H

    2014-05-14

    Host specialization by pathogens requires a repertoire of virulence factors as well as fine-tuned regulation of gene expression. The fungal wheat pathogen Zymoseptoria tritici (synonym Mycosphaerella graminicola) is a powerful model system for the discovery of genetic elements that underlie virulence and host specialization. We transcriptionally profiled the early stages of Z. tritici infection of a compatible host (wheat) and a noncompatible host (Brachypodium distachyon). The results revealed infection regulatory programs common to both hosts and genes with striking wheat-specific expression, with many of the latter showing sequence signatures of positive selection along the Z. tritici lineage. Genes specifically regulated during infection of wheat populated two large clusters of coregulated genes that may represent candidate pathogenicity islands. On evolutionarily labile, repeat-rich accessory chromosomes (ACs), we identified hundreds of highly expressed genes with signatures of evolutionary constraint and putative biological function. Phylogenetic analyses suggested that gene duplication events on these ACs were rare and largely preceded the diversification of Zymoseptoria species. Together, our data highlight the likely relevance for fungal growth and virulence of hundreds of Z. tritici genes, deepening the annotation and functional inference of the genes of this model pathogen. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  11. Binge Drinking in Female College Students: The Association of Physical Activity, Weight Concern, and Depressive Symptoms.

    Science.gov (United States)

    Vickers, Kristin S.; Patten, Christi A.; Bronars, Carrie; Lane, Kristi; Stevens, Susanna R.; Croghan, Ivana T.; Schroeder, Darrell R.; Clark, Matthew M.

    2004-01-01

    As an initial step in building gender-specific binge drinking intervention programs, the authors investigated the relation of potentially modifiable factors (physical activity level, weight concern, and depressive symptoms) to binge drinking while controlling for the effects of previously established correlates of binge drinking (tobacco and…

  12. Body Image Concerns

    DEFF Research Database (Denmark)

    El Ansari, Walid; Dibba, Emily; Stock, Christiane

    2014-01-01

    AIMS: This cross-sectional study aimed to determine the socio-demographic, lifestyle and well-being variables that are associated with body image concerns (BIC) and whether these associations differed between female and male students. METHODS: A cross-sectional survey; 3,706 undergraduate students...... (2,699 females, 765 males) from seven universities in the UK completed a self-administered questionnaire that assessed socio-demographic, lifestyle, well-being and BIC based on the Body Shape Questionnaire developed by Cooper et al. Multifactorial logistic regression analysis examined the odds ratios......, perceived health, depressive symptoms) on the other. RESULTS: More females (35%) than males (8%) reported being moderately or markedly concerned with their body image. For both genders, BIC was associated with a higher level of depressive symptoms and to variable extents, with nutrition and year...

  13. The Question Concerning Thinking

    DEFF Research Database (Denmark)

    Riis, Søren

    2008-01-01

    Martin Heidegger's thought-provoking essay "The Question Concerning Technology" (1977a) placed technology at the heart of philosophy. Heidegger tried to show that the essence of technology provokes humans to think about the world in a very dangerous way. Yet if we follow Heidegger's analysis...... of technology, what role does that ascribe to philosophy? To be able to understand the programmatic scope of Heidegger's question ‘concerning' technology, we need to see it as inseparable from his famous thesis about the end of philosophy (1977c) and what he considers to be the ideal kind of thinking. However......, by doing so, we will in the end realize two important things. First, that Heidegger's declaration of the end of philosophy in fact also means the end of anything we can meaningfully call thinking. Second, that Heidegger's own thinking is completely different from his own ideal of thinking. Our question...

  14. IMPORTANT CONCERN INVESTMENT MANAGEMENT

    Directory of Open Access Journals (Sweden)

    SINTEA (ANGHEL LUCICA

    2014-06-01

    Full Text Available The issue of probabilities, uncertainties and risks has concerned society since ancient times. By probability we can see the possible realization of an act or event under certain conditions. Uncertainty is caused by emotional status of the decision maker due to more subjective factors or to the knowledge to achieve an objective. Risk is a combination of the two elements characterized by a possible description of probabilities under insecurity uncertainty conditions.

  15. Altruism and Career Concerns

    OpenAIRE

    Shchetinin, Oleg

    2009-01-01

    The paper studies the impact of altruism on Agent’s motivation in the career concerns model. The paper shows the new channel of interaction between intrinsic and extrinsic motivation. The common point in the literature is that intrinsic motivation can be crowded out by the extrinsic incentives. My paper shows that crowding effect can go in the opposite direction: extrinsic incentives can be lessened for the intrinsically motivated agent. The analysis shows that altruism can decrea...

  16. The effectiveness of an aged care specific leadership and management program on workforce, work environment, and care quality outcomes: design of a cluster randomised controlled trial

    OpenAIRE

    Jeon, Yun-Hee; Simpson, Judy M; Chenoweth, Lynn; Cunich, Michelle; Kendig, Hal

    2013-01-01

    Background A plethora of observational evidence exists concerning the impact of management and leadership on workforce, work environment, and care quality. Yet, no randomised controlled trial has been conducted to test the effectiveness of leadership and management interventions in aged care. An innovative aged care clinical leadership program (Clinical Leadership in Aged Care − CLiAC) was developed to improve managers’ leadership capacities to support the delivery of quality care in Australi...

  17. Markets for Collective Concerns

    DEFF Research Database (Denmark)

    Frankel, Christian; Ossandón, José; Pallesen, Trine

    Despite the recent fall-out of finance, confidence in the market does not seem to be diminishing, but, on the contrary, market mechanisms are becoming key instruments to deal with core contemporary collective concerns, including global warming, education, environmental pollution, supply of energy......, quality of education, poverty and health care (Mirowski 2013). Recent research within STS has started to focus on such kind of arrangements and in this presentation we will critically engage with this literature. Our main results are twofold. On the one hand, we recognize there are important conceptual...

  18. Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner.

    Science.gov (United States)

    Lecoutre, Simon; Oger, Frederik; Pourpe, Charlène; Butruille, Laura; Marousez, Lucie; Dickes-Coopman, Anne; Laborie, Christine; Guinez, Céline; Lesage, Jean; Vieau, Didier; Junien, Claudine; Eberlé, Delphine; Gabory, Anne; Eeckhoute, Jérôme; Breton, Christophe

    2017-08-01

    According to the Developmental Origin of Health and Disease (DOHaD) concept, maternal obesity and accelerated growth in neonates predispose offspring to white adipose tissue (WAT) accumulation. In rodents, adipogenesis mainly develops during lactation. The mechanisms underlying the phenomenon known as developmental programming remain elusive. We previously reported that adult rat offspring from high-fat diet-fed dams (called HF) exhibited hypertrophic adipocyte, hyperleptinemia and increased leptin mRNA levels in a depot-specific manner. We hypothesized that leptin upregulation occurs via epigenetic malprogramming, which takes place early during development of WAT. As a first step, we identified in silico two potential enhancers located upstream and downstream of the leptin transcription start site that exhibit strong dynamic epigenomic remodeling during adipocyte differentiation. We then focused on epigenetic modifications (methylation, hydroxymethylation, and histone modifications) of the promoter and the two potential enhancers regulating leptin gene expression in perirenal (pWAT) and inguinal (iWAT) fat pads of HF offspring during lactation (postnatal days 12 (PND12) and 21 (PND21)) and in adulthood. PND12 is an active period for epigenomic remodeling in both deposits especially in the upstream enhancer, consistent with leptin gene induction during adipogenesis. Unlike iWAT, some of these epigenetic marks were still observable in pWAT of weaned HF offspring. Retained marks were only visible in pWAT of 9-month-old HF rats that showed a persistent "expandable" phenotype. Consistent with the DOHaD hypothesis, persistent epigenetic remodeling occurs at regulatory regions especially within intergenic sequences, linked to higher leptin gene expression in adult HF offspring in a depot-specific manner.

  19. Concerned for Humanity club

    CERN Multimedia

    Concerned for humanity club

    2010-01-01

    Join the Comité International de Soutien à Adlène Hicheur Since October 8, 2009 our colleague Adlène Hicheur, a French-Algerian physicist working in LHCb has been arrested and then held in a French prison under suspicion of terrorism linked with AQMI. No material proof has been presented, only exchanges of messages on some forum sites suspected of Islamism have been mentioned. Adlène has continuously denied any link with AQMI and lives in a Kafkaesque situation since 14 mois. His lawyer has several times asked for his release and these requests have been turned down. As Adlène’s colleagues, we have been chocked by his arrest and are deeply concerned by the prolongation of his detention for his future in particle physics, even if he will be recognized innocent. Few Concerned-club members and colleagues have created an International committee to support Adlène in his defense presently having 65 members. We invite you t...

  20. Possible effect of implementing a national query program on site-specific cancer mortality rates in Taiwan.

    Science.gov (United States)

    Lin, Ching-Yih; Cheng, Tain-Junn; Peng, Hua-Chun; Chen, Lea-Hua; Huang, Shiuh-Ming; Lu, Tsung-Hsueh

    2014-01-01

    This study aimed to examine possible effects of implementing a national query program on site-specific cancer mortality rates. A total of 2,874 query letters were sent out by the Department of Statistics, Ministry of Health and Welfare of Taiwan between January 2009 and December 2011 to medical certifiers who reported "neoplasm with uncertain nature" on the death certificate asking for more detailed information for coding. Of the 2,571 responses, in 1,398 cases (54%) medical certifiers were still unable to determine the nature of the neoplasm. There were four neoplasm sites for which more than 50% of the responses changed the category to malignant, the gastrointestinal system (73%), urinary system (60%), stomach (55%) and rectum (53%). The liver was the cancer site that showed the largest absolute increase in the number of deaths after the query; however, the brain showed the largest relative increase, at 12%. Different neoplasm sites showed different magnitudes of change in nature after the query. Brain cancer mortality rates exhibited the largest increase.

  1. The Effect of Neuro-Linguistic Programming (NLP on Reading Comprehension in English for Specific Purposes Courses

    Directory of Open Access Journals (Sweden)

    Fahimeh Farahani

    2018-01-01

    Full Text Available Neuro-Linguistic Programming (NLP has potential to help language learners; however, it has received scant attention. The present study was an attempt to investigate the effect of NLP techniques on reading comprehension of English as a Foreign Language (EFL learners at an English for Specific Purposes (ESP course. To achieve this goal, two intact classes of students were selected to form an experimental group (n=30 and a control group (n=30. A reading pretest (based on the course content was given to all participants. The sensory learning styles of the participants were diagnosed using Reid's (1987 leaning style questionnaire, and the participants in the experimental group were familiarized with NLP techniques to be able to implement these techniques in their reading. In the control group, the conventional approach to teach ESP reading was used. Considering the analysis of posttest results through ANCOVA, it was found that implementation of NLP techniques can have significant effect on reading comprehension of Iranian undergraduate EFL learners. Pedagogical implications are discussed.

  2. High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1.

    Directory of Open Access Journals (Sweden)

    Jennifer L Schehr

    Full Text Available Expression of programmed-death ligand 1 (PD-L1 in non-small cell lung cancer (NSCLC is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs may be a less invasive method to assay tumor cells for these purposes. These liquid biopsies rely on accurate identification of CTCs from the diverse populations in the blood, where some tumor cells share characteristics with normal blood cells. While many blood cells can be excluded by their high expression of CD45, neutrophils and other immature myeloid subsets have low to absent expression of CD45 and also express PD-L1. Furthermore, cytokeratin is typically used to identify CTCs, but neutrophils may stain non-specifically for intracellular antibodies, including cytokeratin, thus preventing accurate evaluation of PD-L1 expression on tumor cells. This holds even greater significance when evaluating PD-L1 in epithelial cell adhesion molecule (EpCAM positive and EpCAM negative CTCs (as in epithelial-mesenchymal transition (EMT.To evaluate the impact of CTC misidentification on PD-L1 evaluation, we utilized CD11b to identify myeloid cells. CTCs were isolated from patients with metastatic NSCLC using EpCAM, MUC1 or Vimentin capture antibodies and exclusion-based sample preparation (ESP technology.Large populations of CD11b+CD45lo cells were identified in buffy coats and stained non-specifically for intracellular antibodies including cytokeratin. The amount of CD11b+ cells misidentified as CTCs varied among patients; accounting for 33-100% of traditionally identified CTCs. Cells captured with vimentin had a higher frequency of CD11b+ cells at 41%, compared to 20% and 18% with MUC1 or EpCAM, respectively. Cells misidentified as CTCs ultimately skewed PD-L1 expression to varying degrees across patient samples.Interfering myeloid populations can be differentiated from true CTCs with additional staining criteria, thus improving the

  3. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

    DEFF Research Database (Denmark)

    Kløverpris, Henrik N; McGregor, Reuben; McLaren, James E

    2014-01-01

    ), CD244 and lymphocyte activation gene-3 (LAG-3), which modulate the functional capabilities of CD8+ T cells. DESIGN AND METHODS: Here, we used an array of different human leukocyte antigen(HLA)-B*15:03 and HLA-B*42:01 tetramers to characterize inhibitory receptor expression as a function...... by effector memory CD8+ T cells. CONCLUSION: Collectively, these data suggest that PD-1 expression on HIV-1-specific CD8+ T cells tracks antigen load at the level of epitope specificity and TCR clonotype usage. These findings are important because they provide evidence that PD-1 expression levels...

  4. Concerns About STEM Education Restructure

    Science.gov (United States)

    Showstack, Randy

    2013-05-01

    Several education experts told Eos that they generally favored some improvements in U.S. federal science, technology, engineering, and mathematics (STEM) education, but they also expressed concern about the Obama administration's proposed STEM reorganization plan as it affects the National Oceanic and Atmospheric Administration (NOAA). John Farrington, chair of the U.S. National Research Council (NRC) panel that issued a review of the NOAA education program in 2010, told Eos that he is confident that a considerable amount of thought went into this proposal to consolidate the K-12 STEM efforts, that consolidation could make for greater efficiencies, and that a positive aspect of having the Department of Education (ED) as a lead is that STEM education should not be considered as separate from the education of the student as a whole.

  5. Medical concerns of marathons.

    Science.gov (United States)

    Jaworski, Carrie A

    2005-06-01

    One must remember that the first marathon runner, Phidippides, collapsed and died at the finish of his race. Fortunately, death has been an infrequent occurrence in modern day marathons. However, the physical exertion required to complete a marathon coupled with exposure to often harsh environmental conditions and an increase in the number of novice participants makes injuries inevitable. The medical team's main goal is to implement strategies to prevent serious injury and illness through pre-event planning, race day preparedness, and postevent evaluations. The three general categories of injuries encountered with marathon participation include medical conditions, musculoskeletal injuries, and dermatologic complaints. The focus of this article is on the evaluation and management of the varied medical concerns encountered on race day along with the essentials in prerace planning and preparedness.

  6. Aesthetics of Concern

    DEFF Research Database (Denmark)

    Thorsen, Line Marie

    2013-01-01

    In the wake of Hurricane Katrina in 2005 and the tsunami that hit Japan in 2011, several artists turned  their  practices  towards  the  subject  of  disaster  support.  Drawing on the philosophy of Bruno Latour, I argue that these artistic practices come  to articulate and  represent the multitude of concerns interwoven with disaster.  ...

  7. [Unpublished documents concerning Dupuytren].

    Science.gov (United States)

    Boulinier, G

    1996-01-01

    In the present paper is proposed a first incursion in various archives - mainly notarial ones - concerning Dupuytren and his close relatives, investigated by the author. They will be more thoroughly dealt with in a forthcoming book. These documents give us a better knowledge of various events of Dupuytren's public and private life. They namely disclose the great challenge shown by the surgeon-in-chief of the Hôtel-Dieu in marrying his daughter Adeline in the midst of the Paris cholera epidemic in 1832. They show moreover in this unusual character the essential role continually played by some preoccupations such as nobility, power, religion and wealth, amidst a family of which he is the only member to have shown the ambition to become famous in the medical field.

  8. An Evaluation of the Effectiveness of Local Site-Specific Advisory Boards for US Department of Energy Environmental Restoration Programs

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, J.A.; Branch, K.M.

    1999-03-12

    In the early 1990s, the US Department of Energy (DOE) undertook a major new effort to involve community stakeholders in decisions that would affect them and their communities and interests. An important component of this effort was the establishment of local Site-Specific Advisory Boards (SSABs) at 12 DOE environmental remediation sites. These boards were a formal representation of a change in the way DOE conducts its missions, adding consideration of community concerns and values to the Department's decision-making processes. DOE's purpose in creating the SSAB Initiative was to obtain broadly based, independent, consensus advice and recommendations on issues that have the potential to affect communities surrounding DOE sites, so that it could formulate policies that could be implemented with community consent. Because the boards represented a significant commitment by DOE to change its relationships with community stakeholders, the Department has conducted several assessments of the boards. In 1996 and 1997 a survey was administered to board members and others involved in the work of the boards (DOE/EM 0311, 1996; DOE/EM, 1997). As part of the first survey, DOE and the boards established a set of performance criteria. The surveys provided data that revealed wide variations in board performance and significant change over time. To gain a better understanding of the factors affecting board performance, DOE initiated a more in-depth, qualitative study of nine of the boards across the complex. This study focused on identifying and analyzing the factors affecting board performance and presenting that information in a format that helped the boards and DOE gain insight into their strengths and weaknesses and learn from one another. This report presents the results of this in-depth study. It begins with an overview report that identifies and discusses the six factors that were found to affect board performance. The overview report provides the framework and

  9. global health concerns

    African Journals Online (AJOL)

    FEMALE GENITAL MUTILATION ing from difficult sexual encounters or from lack of arousal or pain experienced by their wives. Many frequently present with many unremitting non-specific urologic complaints. It is therefore imperative that urologists initiate discussions regarding sexual activity and potential risks to the patient ...

  10. Incidence and age-specific presentation of restrictive eating disorders in children: a Canadian Paediatric Surveillance Program study.

    Science.gov (United States)

    Pinhas, Leora; Morris, Anne; Crosby, Ross D; Katzman, Debra K

    2011-10-01

    To document and describe the incidence and age-specific presentation of early-onset restrictive eating disorders in children across Canada. Surveillance study. Cases were ascertained through the Canadian Paediatric Surveillance Program by surveying approximately 2453 Canadian pediatricians (a 95% participation rate) monthly during a 2-year period. Canadian pediatric practices. Pediatricians and pediatric subspecialists. A description of clinical presentations and characteristics of eating disorders in this population and the incidence of restrictive eating disorders in children. The incidence of early-onset restrictive eating disorders in children aged 5 to 12 years seen by pediatricians was 2.6 cases per 100 000 person-years. The ratio of girls to boys was 6:1, and 47.1% of girls and 54.5% of boys showed signs of growth delay. Forty-six percent of children were below the 10th percentile for body mass index, 34.2% were initially seen with unstable vital signs, and 47.2% required hospital admission. Only 62.1% of children met criteria for anorexia nervosa. Although children with anorexia nervosa were more likely to be medically compromised, some children who did not meet criteria for anorexia nervosa were equally medically unstable. Young children are seen with clinically significant restrictive eating disorders, with the incidence exceeding that of type 2 diabetes mellitus. These eating disturbances can result in serious medical consequences, ranging from growth delay to unstable vital signs, which can occur in the absence of weight loss or other restrictive eating disorder symptoms.

  11. Expression of Concern.

    Science.gov (United States)

    2017-11-01

    The Journal Editors hereby issue this note of an expression of concern for the following publication: Benjamin, A. J., Jr., Kepes, S., & Bushman, B. J. (2017). Effects of weapons on aggressive thoughts, angry feelings, hostile appraisals, and aggressive behavior: A meta-analytic review of the weapons effect literature. Personality and Social Psychology Review. Advance online publication. doi:10.1177/1088868317725419 The authors of this manuscript contacted the editors indicating they had discovered some errors in the computation of effect sizes in their meta-analysis. Initial reanalysis suggested that at least one of the substantive conclusions of the manuscript was affected by the error; the authors now urge greater caution in interpreting the effect size of weapons on aggressive behavioral outcomes. The authors will undertake a thorough reanalysis and will modify the results and interpretations accordingly, and this notice will be updated upon their completion of the modifications. The editorial staff appreciates the proactive efforts of the authors in this matter. The Editors and SAGE strive to uphold the very highest standards of publication ethics and are committed to supporting the high standards of integrity of Personality and Social Psychology Review. Authors, reviewers, editors, and interested readers should consult the ethics section of SAGE and the Committee on Publication Ethics (COPE) website for guidelines on publication ethics.

  12. Availability and Accessibility of Student-Specific Weight Loss Programs and Other Risk Prevention Health Services on College Campuses

    OpenAIRE

    Lynch, Sarah; Hayes, Sharon; Napolitano, Melissa; Hufnagel, Katrina

    2016-01-01

    Background More than one third of college students who are overweight or obese are in need of weight loss programs tailored to college students. However, the availability and accessibility of these programs is unknown. Objective The aim of this study is to examine the availability and ease of access to weight loss programs for students at 10 universities with the largest undergraduate enrollment. Methods The 10 public universities with the largest student bodies with a mean (SD) undergraduate...

  13. Appearance concerns in ophthalmic patients

    Science.gov (United States)

    James, H; Jenkinson, E; Harrad, R; Ezra, D G; Newman, S

    2011-01-01

    Aims This study aimed to determine the psychosocial and appearance-related concerns of a sample of ophthalmic patients by measuring a range of psychological, social, and demographic factors. Methods Standardized psychological measures including anxiety, depression, appearance-related distress, self-discrepancy, appearance salience and valence were administered to 98 participants attending ophthalmic outpatient clinics in either London, Bristol, Sheffield or Bradford. Differences between groups were explored using t-tests and ANOVA, relationships between all variables were investigated using Pearson's correlation coefficient. Results Although mean scores for psychological adjustment were within the normal range, some participants were experiencing considerable levels of generalized anxiety. Being older, male, and married or living with a partner was related to significantly better adjustment. Better adjustment was also related to a less visible area of concern, greater disguisability of the affected area, a more positive evaluation of their own appearance, less engagement in comparing themselves with others, greater feelings of being accepted by others, appearance being less important to their self-concept, and a smaller discrepancy between the persons ideal and actual appearance. Conclusions A majority of ophthalmic patients adjust positively to the demands placed on them. By identifying the variables that are associated with successful adaptation, the specific psychological interventions and appropriate systems of support can be put in place to help those who are adversely affected. PMID:21597486

  14. Looking to the Future--The Role of Master's Programs in Counseling Psychology: A Response to Quality of Master's Education: A Concern for Counseling Psychology?

    Science.gov (United States)

    Horne, Arthur M.

    2013-01-01

    The predoctoral relationship that counseling psychology programs have had with master's programs over the decades is being challenged in current times. A model that is developing is one that provides greater responsibility for program definition and then full faculty engagement from doctoral program faculty. With change occurring in training…

  15. The Concerns of Beginning Nursing Students.

    Science.gov (United States)

    Williams, Rhea P.

    1993-01-01

    A descriptive correlational study looked at the concerns of nursing students (n=245) as they began their nursing education program. Among the most stressful areas cited were academic work, long hours of study, lack of sufficient clinical knowledge and experience to complete the task, and relationship with faculty. (JOW)

  16. Lead toxicity: Current concerns

    Energy Technology Data Exchange (ETDEWEB)

    Goyer, R.A. (Univ. of Western Ontario, London (Canada))

    1993-04-01

    Over the 20-year period since the first issue of Environmental Health Perspectives was published, there has been considerable progress in the understanding of the potential toxicity of exposure to lead. Many of these advances have been reviewed in published symposia, conferences, and review papers in EHP. This brief review identifies major advances as well as a number of current concerns that present opportunities for prevention and intervention strategies. The major scientific advance has been the demonstration that blood lead (PbB) levels of 10-15 micrograms/dL in newborn and very young infants result in cognitive and behavioral deficits. Further support for this observation is being obtained by prospective or longitudinal studies presently in progress. The mechanism(s) for the central nervous system effects of lead is unclear but involve lead interactions within calcium-mediated intracellular messenger systems and neurotransmission. Effects of low-level lead exposure on blood pressure, particularly in adult men, may be related to the effect of lead on calcium-mediated control of vascular smooth muscle contraction and on the renin-angiotensin system. Reproductive effects of lead have long been suspected, but low-level effects have not been well studied. Whether lead is a carcinogen or its association with renal adenocarcinoma is a consequence of cystic nephropathy is uncertain. Major risk factors for lead toxicity in children in the United States include nutrition, particularly deficiencies of essential metals, calcium, iron, and zinc, and housing and socioeconomic status. A goal for the year 2000 is to reduce prevalence of blood lead levels exceeding 15 micrograms/dL. 97 refs.

  17. Math Instruction Is Not Universal: Language-Specific Pedagogical Knowledge in Korean/English Two-Way Immersion Programs

    Science.gov (United States)

    Lee, Wona; Lee, Jin Sook

    2017-01-01

    Two-Way Immersion (TWI) programs have demonstrated positive outcomes in students' academic achievement in English, yet less is known about content teaching and learning in the non-English language in these programs. This study uses math instruction as a lens to identify pedagogical strategies and challenges in the teaching of math in Korean to…

  18. Aspect-Oriented Programming

    Science.gov (United States)

    Elrad, Tzilla (Editor); Filman, Robert E. (Editor); Bader, Atef (Editor)

    2001-01-01

    Computer science has experienced an evolution in programming languages and systems from the crude assembly and machine codes of the earliest computers through concepts such as formula translation, procedural programming, structured programming, functional programming, logic programming, and programming with abstract data types. Each of these steps in programming technology has advanced our ability to achieve clear separation of concerns at the source code level. Currently, the dominant programming paradigm is object-oriented programming - the idea that one builds a software system by decomposing a problem into objects and then writing the code of those objects. Such objects abstract together behavior and data into a single conceptual and physical entity. Object-orientation is reflected in the entire spectrum of current software development methodologies and tools - we have OO methodologies, analysis and design tools, and OO programming languages. Writing complex applications such as graphical user interfaces, operating systems, and distributed applications while maintaining comprehensible source code has been made possible with OOP. Success at developing simpler systems leads to aspirations for greater complexity. Object orientation is a clever idea, but has certain limitations. We are now seeing that many requirements do not decompose neatly into behavior centered on a single locus. Object technology has difficulty localizing concerns invoking global constraints and pandemic behaviors, appropriately segregating concerns, and applying domain-specific knowledge. Post-object programming (POP) mechanisms that look to increase the expressiveness of the OO paradigm are a fertile arena for current research. Examples of POP technologies include domain-specific languages, generative programming, generic programming, constraint languages, reflection and metaprogramming, feature-oriented development, views/viewpoints, and asynchronous message brokering. (Czarneclu and

  19. Concerns about aging and caregiving among middle-aged and older lesbian and gay adults.

    Science.gov (United States)

    Czaja, Sara J; Sabbag, Samir; Lee, Chin Chin; Schulz, Richard; Lang, Samantha; Vlahovic, Tatiana; Jaret, Adrienne; Thurston, Catherine

    2016-11-01

    Despite the increasing number of lesbian and gay older adults, research geared towards health and well-being of this population is limited. Many lesbian and gay seniors experience health disparities and are at risk for poor health outcomes. The aims of this study were to gather in-depth information on the concerns of lesbian and gay elders with respect to aging and care needs. The sample included 124 gay men and lesbian women aged 50+ years. Data were gathered via focus groups and questionnaires. The focus groups addressed: (1) concerns about aging in the LGBT community, (2) barriers to needed support and services, (3) concerns about caregiving and (4) needed programs for lesbian and gay seniors. Concerns expressed about aging included: lack of financial security, lack of family or social support, fears about the lack of someone to provide needed care, and discrimination in healthcare or service communities. Participants also indicated concerns about being alone and vulnerable and a need for resources and support programs, specifically for lesbian and gay older adults and for lesbian and gay caregivers. These findings suggest needed areas of support and programs for older gay men and lesbian women. They also suggest that healthcare professionals might need more training regarding the particular needs and concerns of this community.

  20. 5 CFR 370.107 - Details to small business concerns.

    Science.gov (United States)

    2010-01-01

    ... INFORMATION TECHNOLOGY EXCHANGE PROGRAM § 370.107 Details to small business concerns. (a) The head of each... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Details to small business concerns. 370... organizations in each calendar year, at least 20 percent are to small business concerns, in accordance with 5 U...

  1. 42 CFR 422.2260 - Definitions concerning marketing materials.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Definitions concerning marketing materials. 422... HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Advantage Marketing Requirements § 422.2260 Definitions concerning marketing materials. As used in this subpart— Marketing...

  2. Program NetMoment; Simultaneous Calculation of Moment, Source Corner Frequency, and Site Specific t* from Network Recordings

    Energy Technology Data Exchange (ETDEWEB)

    Hutchings, L

    2001-12-12

    The purpose of computer program NetMoment (Appendix I) is to utilize fundamental knowledge of earthquake sources, propagation attenuation, and site response in a simultaneous inversion of network data to determine the moment and source corner frequency of earthquakes, and site specific t*. The source parameters are especially difficult to determine for small earthquakes. A fundamental problem in determining the source corner frequencies of small earthquakes is that site response can result in spectral corner frequencies in the range that may be expected from the earthquakes themselves. Several authors have identified this as fmax (Hanks, 1982), a constant corner frequency for small events so that below threshold moment (about 1.0 x 10{sup 21} dyne-cm) the corner frequency remains constant the size of events diminishes. Hutchings and Wu (1990) found that for the southern California region, events with moment less than about 1.5 x 10{sup 21} dyne-cm (about magnitude 3.4) show no source effect in their spectra. Hanks (1982) found the threshold to be about 1.0 x l0{sup 21} dyne-cm for other southern California sites. Baise et al. (2002) found borehole recordings on Yerba Buena Island, in San Francisco Bay, to have corner frequencies limited to about 3-5 Hz for M < 4.0 earthquakes in the region. Some authors have attributed this to a minimum source dimension for earthquakes, which results in a decrease in stress drop for smaller events (Archuleta et al., 1982; Papageorgiou and Aki, 1983). alternative explanation is that the constant corner frequencies result from whole path or near site attenuation and/or amplifications due to soil response. This is supported by a wide body of literature (Anderson and Hough, 1984, Hutchings and Wu, 1990, Blakeslee and Malin, 1991; Aster and Shearer, 1991; Abercrombie, 1995). Abercrombie, for example, estimated source corner frequencies from events recorded in granite at a depth of 2.5 Km in the Cajon Pass scientific drill hole and

  3. Policy gridlock in waste management: Balancing federal and state concerns

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, D.L. [Oak Ridge National Lab., TN (United States); Peretz, J.H.; Jendrucko, B.K. [Univ. of Tennessee, Knoxville, TN (United States)

    1993-12-31

    Current federal hazardous and low-level radioactive waste management policies fail to balance national concerns for policy consistency with state concerns for equity, discretion, and adequate resources. Failure to balance these competing values has resulted in {open_quotes}policy gridlock{close_quotes} - exemplified by conflicts over the Resource Conservation and Recovery Act and the Low-Level Radioactive Waste Policy Acts. Both conflicts have resulted in recent U.S. Supreme Court litigation. After reviewing federal-state conflict in hazardous and low-level radioactive waste management, we propose that the solution to gridlock lies in modifying conjoint federalism. Conjoint federalism allows for joint responsibility for waste policy between federal and state governments, with state programs meeting minimum standards set by federal programs. However, conjoint federalism does not currently allow for sufficient state discretion, which is paramount for successful waste management programs. Specifically, Congress should expand conjoint federalism, to allow states to charge differential fees on imported hazardous waste as is done for low-level radioactive waste. This expansion would encourage waste minimization and better interstate planning.

  4. The Retention Question in Context-Specific Teacher Education: Do Beginning Teachers and Their Program Leaders See Teachers' Future Career Eye to Eye

    Science.gov (United States)

    Tamir, Eran

    2010-01-01

    This paper discusses the challenge of retaining teachers in hard-to-staff schools by examining how it is addressed in three context specific teacher education programs, which prepare teachers to teach in urban public, urban Catholic, and Jewish Day Schools in U.S.A. The findings of this study suggest that counter to teaching force trends teachers…

  5. Effects of a Specifically Designed Physical Conditioning Program on the Load Carriage and Lifting Performance of Female Soldiers

    National Research Council Canada - National Science Library

    Harman, Everett

    1997-01-01

    Forty-six women were studied to determine whether their ability to perform 'very heavy' Army jobs could be improved by a specially designed 24-week physical training program administered within normal...

  6. Effects of a Specifically Designed Physical Conditioning Program on the Load Carriage and Lifting Performance of Female Soldiers

    National Research Council Canada - National Science Library

    Harman, Everett

    1997-01-01

    Forty-six women were studied to determine whether their ability to perform "very heavy" Army jobs could be improved by a specially designed 24-week physical training program administered within normal...

  7. Wheelchair Propulsion Biomechanics in Junior Basketball Players: A Method for the Evaluation of the Efficacy of a Specific Training Program

    National Research Council Canada - National Science Library

    Bergamini, Elena; Morelli, Francesca; Marchetti, Flavia; Vannozzi, Giuseppe; Polidori, Lorenzo; Paradisi, Francesco; Traballesi, Marco; Cappozzo, Aurelio; Delussu, Anna Sofia

    2015-01-01

      As participation in wheelchair sports increases, the need of quantitative assessment of biomechanical performance indicators and of sports- and population-specific training protocols has become central...

  8. Undergraduate Course on Global Concerns

    Science.gov (United States)

    Richard, G. A.; Weidner, D. J.

    2008-12-01

    GEO 311: Geoscience and Global Concerns is an undergraduate course taught at Stony Brook University during each fall semester. The class meets twice per week, with one session consisting of a lecture and the other, an interactive activity in a computer laboratory that engages the students in exploring real world problems. A specific concern or issue serves as a focus during each session. The students are asked to develop answers to a series of questions that engage them in identifying causes of the problem, connections with the Earth system, relationships to other problems, and possible solutions on both a global and local scale. The questions are designed to facilitate an integrated view of the Earth system. Examples of topics that the students explore during the laboratory sessions are: 1) fossil fuel reserves and consumption rates and the effect of their use on climate, 2) alternative sources of energy and associated technologies, such as solar photovoltaics, nuclear energy, tidal power, geothermal energy, and wind power, 3) effects of tsunamis and earthquakes on human populations and infrastructure, 4) climate change, and 5) hurricanes and storms. The selection and scheduling of topics often takes advantage of the occurrence of media attention or events that can serve as case studies. Tools used during the computer sessions include Google Earth, ArcGIS, spreadsheets, and web sites that offer data and maps. The students use Google Earth or ArcGIS to map events such as earthquakes, storms, tsunamis, and changes in the extent of polar ice. Spreadsheets are employed to discern trends in fossil fuel supply and consumption, and to experiment with models that make predictions for the future. We present examples of several of these activities and discuss how they facilitate an understanding of interrelationships within the Earth system.

  9. Concerns in Marine Renewable Energy Projects

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, Sharon; Previsic, Mirko; Nelson, Peter; Woo, Sheri

    2010-06-17

    To accelerate the adoption of these emerging marine hydrokinetic technologies, navigational and environmental issues and concerns must be identified and addressed. As hydrokinetic projects move forward, various stakeholders will need to be engaged; one of the key issues that project proponents face as they engage stakeholders is that many conflicting uses and environmental issues are not well-understood. Much of this lack of understanding comes from a limited understanding of the technologies themselves. To address this issue, in September 2008, RE Vision consulting, LLC, was selected by the Department of Energy, under their market acceleration program, to apply a scenario-based assessment approach to the emerging hydrokinetic technology sector. The goal was to improve understanding of potential environmental and navigation impacts of these technologies and focus stakeholders on the critical issues. To meet this goal, the study established baseline scenarios for wave and tidal power conversion at potential future deployment sites. The scenarios captured variations in technical approaches and deployment scales and thus grounded the analysis in realistic constraints. The work conducted under this award provides an important foundation to other market acceleration activities carried out by the DOE and other stakeholders in this sector. The scenarios were then evaluated using a framework developed by H.T. Harvey & Associates to identify and characterize key environmental concerns and uncertainties. In collaboration with PCCI and the U.S. Coast Guard, navigation issues were assessed and guidelines developed to assure the safe operation of these systems. Finally, the work highlights “next steps” to take to continue development and adoption of marine hydrokinetic energy. Throughout the project, close collaboration with device developers, project developers and regulatory stakeholders was pursued to ensure that assumptions and constraints are realistic. Results concur

  10. KEMAMPUAN SUBJECT SPECIFIC PEDAGOGY CALON GURU BIOLOGI PESERTA PROGRAM PENDIDIKAN PROFESIONAL GURU (PPG YANG BERLATAR BELAKANG BASIC SAINS PRA DAN POST WORKSHOP

    Directory of Open Access Journals (Sweden)

    Yenny Anwar

    2012-10-01

    Full Text Available Penelitian ini bertujuan untuk menggambarkan/mendeskripsikan kemampuan Subjek Spesifik Pedagogi mahasiswa calon guru biologi yang mengikuti program Pendidikan Profesional Guru (PPG angkatan 2012-2013 melalui pendekatan konsekutif.  Hasil sementara menunjukkan  bahwa Kemampuan Subject Specific Pedagogy mahasiswa calon guru biologi yang berlatar belakang Biologi murni program Basic Science masih minim, dapat dilihat dari hasil CoRes dan PaP-eRs buatan mereka sebelum mengikuti workshop. Setelah workshop semester I diperoleh hasil yang menunjukkan peningkatan yang cukup baik.   This study aimed to describe / describes the ability of prospective students Subject Specific Pedagogy biology teachers who follow the Professional Teacher Education Program (PTEP 2012-2013 armed consecutive approach. Preliminary results indicate that the ability of prospective students Subject Specific Pedagogy biology teacher who belongs to the pure Biology Basic Science program is minimal, it can be seen from the cores and pap-ers made ​​them before the workshop. After the workshop the first half of the obtained results that showed a pretty good improvement.

  11. Effectiveness of Back School program versus hydrotherapy in elderly patients with chronic non-specific low back pain: a randomized clinical trial.

    Science.gov (United States)

    Costantino, Cosimo; Romiti, Davide

    2014-06-24

    Chronic low back pain (CLBP) is a major cause of disability, for which clinical practice guidelines suggest exercise programs, such as Back School program (stretching and selective muscle reinforcement techniques) and Hydrotherapy technique, as an effective treatment to reduce pain intensity and disability. We enrolled 56 elderly individuals, affected by non-specific CLBP, whose pain had worsened in the last three months, which were randomly allocated to Back School (group A) or to Hydrotherapy program (group B). Each group underwent two one-hour-treatment sessions per week, over a 12-week period. Each patient was evaluated using the Roland Morris Disability Questionnaire (RMDQ) and the 36-Item Short Form Health Survey (SF-36) V2.0 at the beginning (T0), at the end of treatment (T1) and at the 3-month follow-up (T2). At T1 and T2 we observed a highly significant statistical difference in the values measured  in both groups: at T1 in group A RMDQ improvement of 3.26±1.02 (p<0.001) and SF-36 of 13.30±1.44 (p<0.001); in group B RMDQ improvement of 4.96±0.71 (p<0.001) and SF-36 of 14.19±1.98 (p<0.001). We have also evaluated the difference in effectiveness of the two programs and no significant statistical differences were found between the two groups. Back School program and Hydrotherapy could be valid treatment options in the rehabilitation of non-specific CLBP in elderly people. Both therapies proved to be effective and can be used in association with other rehabilitation programs. We believe that Back School program should be favored for its simplicity and the small number of resources required. 

  12. Ensuring protection for LGBTI Persons of Concern

    Directory of Open Access Journals (Sweden)

    Volker Türk

    2013-04-01

    Full Text Available Lesbian, gay, bisexual, transgender and intersex (LGBTI asylumseekers and refugees face a myriad of threats, risks and vulnerabilitiesthroughout all stages of the displacement cycle. There needs to begreater awareness not only of the specific protection concerns relatingto LGBTI individuals but also of related jurisprudence and guidanceavailable for UN staff, partners, state authorities and decision-makers.

  13. Multiple mediators of plant programmed cell death : interplay of conserved cell death mechanisms and plant-specific regulators

    NARCIS (Netherlands)

    Hoeberichts, F.A.; Woltering, E.J.

    2002-01-01

    Programmed cell death (PCD) is a process aimed at the removal of redundant, misplaced, or damaged cells and it is essential to the development and maintenance of multicellular organisms. In contrast to the relatively well-described cell death pathway in animals, often referred to as apoptosis,

  14. Maternal obesity programs increased leptin gene expression in rat male offspring via epigenetic modifications in a depot-specific manner

    Directory of Open Access Journals (Sweden)

    Simon Lecoutre

    2017-08-01

    Conclusions: Consistent with the DOHaD hypothesis, persistent epigenetic remodeling occurs at regulatory regions especially within intergenic sequences, linked to higher leptin gene expression in adult HF offspring in a depot-specific manner.

  15. Inconsistencies in Autism-Specific Emotion Interventions: Cause for Concern

    Science.gov (United States)

    Caldeira, Monica; Edmunds, Alan

    2012-01-01

    Precise educational interventions are the sine qua non of services for students with exceptionalities. Applying interventions riddled with inconsistencies, therefore, interferes with the growth and learning potential of students who need these interventions. This research synthesis documents the inconsistencies revealed during a critical analysis…

  16. Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1.

    Science.gov (United States)

    Yu, Xiaoliang; Li, Yun; Chen, Qin; Su, Chenhe; Zhang, Zili; Yang, Chengkui; Hu, Zhilin; Hou, Jue; Zhou, Jinying; Gong, Ling; Jiang, Xuejun; Zheng, Chunfu; He, Sudan

    2015-11-11

    Receptor-interacting protein kinase 3 (RIP3) and its substrate mixed-lineage kinase domain-like protein (MLKL) are core regulators of programmed necrosis. The elimination of pathogen-infected cells by programmed necrosis acts as an important host defense mechanism. Here, we report that human herpes simplex virus 1 (HSV-1) and HSV-2 had opposite impacts on programmed necrosis in human cells versus their impacts in mouse cells. Similar to HSV-1, HSV-2 infection triggered programmed necrosis in mouse cells. However, neither HSV-1 nor HSV-2 infection was able to induce programmed necrosis in human cells. Moreover, HSV-1 or HSV-2 infection in human cells blocked tumor necrosis factor (TNF)-induced necrosis by preventing the induction of an RIP1/RIP3 necrosome. The HSV ribonucleotide reductase large subunit R1 was sufficient to suppress TNF-induced necrosis, and its RIP homotypic interaction motif (RHIM) domain was required to disrupt the RIP1/RIP3 complex in human cells. Therefore, this study provides evidence that HSV has likely evolved strategies to evade the host defense mechanism of programmed necrosis in human cells. This study demonstrated that infection with HSV-1 and HSV-2 blocked TNF-induced necrosis in human cells while these viruses directly activated programmed necrosis in mouse cells. Expression of HSV R1 suppressed TNF-induced necrosis of human cells. The RHIM domain of R1 was essential for its association with human RIP3 and RIP1, leading to disruption of the RIP1/RIP3 complex. This study provides new insights into the species-specific modulation of programmed necrosis by HSV. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  17. WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the soil and sediment task. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Holt, V.L.; Burgoa, B.B.

    1993-12-01

    This document is a site-specific work plan/health and safety checklist (WP/HSC) for a task of the Waste Area Grouping 2 Remedial Investigation and Site Investigation (WAG 2 RI&SI). Title 29 CFR Part 1910.120 requires that a health and safety program plan that includes site- and task-specific information be completed to ensure conformance with health- and safety-related requirements. To meet this requirement, the health and safety program plan for each WAG 2 RI&SI field task must include (1) the general health and safety program plan for all WAG 2 RI&SI field activities and (2) a WP/HSC for that particular field task. These two components, along with all applicable referenced procedures, must be kept together at the work site and distributed to field personnel as required. The general health and safety program plan is the Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169). The WP/HSCs are being issued as supplements to ORNL/ER-169.

  18. Cumulative Poisson Distribution Program

    Science.gov (United States)

    Bowerman, Paul N.; Scheuer, Ernest M.; Nolty, Robert

    1990-01-01

    Overflow and underflow in sums prevented. Cumulative Poisson Distribution Program, CUMPOIS, one of two computer programs that make calculations involving cumulative Poisson distributions. Both programs, CUMPOIS (NPO-17714) and NEWTPOIS (NPO-17715), used independently of one another. CUMPOIS determines cumulative Poisson distribution, used to evaluate cumulative distribution function (cdf) for gamma distributions with integer shape parameters and cdf for X (sup2) distributions with even degrees of freedom. Used by statisticians and others concerned with probabilities of independent events occurring over specific units of time, area, or volume. Written in C.

  19. Concerning video game concerns: A collective approach to conceptually inquiring into their empirical complexity

    DEFF Research Database (Denmark)

    Chimiri, Niklas Alexander; Andersen, Mads Lund; Jensen, Tine

    2017-01-01

    and conceptual development. The complexity of video game concerns, for instance in terms of their digital-analogue entanglements and how these co-enact the effects and meaning of violent video gaming, is neither conceptually debated nor of concern. In DGS, on the other hand, such specificities and entanglements......Concerning video game concerns: A collective approach to conceptually inquiring into their empirical complexity Niklas Alexander Chimirri, Mads Lund Andersen, Tine Jensen, Dorte Marie Søndergaard, Anders Wulff Abstract This paper suggests a collectively developed qualitative approach into inquiring...... and thereby shedding unexpected light on common concerns as expressed in psychological research on video gaming. For years, “The Video Game War” has been reproducing polarized debates on whether games are harmful or not. The search for universal knowledge and unequivocal answers to individual gaming behavior...

  20. Seismic safety margins research program. Phase I. Project VII: systems analysis specifications of computational approach. [PWR; BWR

    Energy Technology Data Exchange (ETDEWEB)

    Collins, J.D.; Hudson, J.M.; Chrostowski, J.D.

    1979-02-01

    A computational methodology is presented for the prediction of core melt probabilities in a nuclear power plant due to earthquake events. The proposed model has four modules: seismic hazard, structural dynamic (including soil-structure interaction), component failure and core melt sequence. The proposed modules would operate in series and would not have to be operated at the same time. The basic statistical approach uses a Monte Carlo simulation to treat random and systematic error but alternate statistical approaches are permitted by the program design.

  1. Near-term hybrid vehicle program, phase 1. Appendix A: Mission analysis and performance specification studies report

    Science.gov (United States)

    1979-01-01

    Results of a study leading to the preliminary design of a five passenger hybrid vehicle utilizing two energy sources (electricity and gasoline/diesel fuel) to minimize petroleum usage on a fleet basis are presented. The study methodology is described. Vehicle characterizations, the mission description, characterization, and impact on potential sales, and the rationale for the selection of the reference internal combustion engine vehicle are presented. Conclusions and recommendations of the mission analysis and performance specification report are included.

  2. The effectiveness of an aged care specific leadership and management program on workforce, work environment, and care quality outcomes: design of a cluster randomised controlled trial.

    Science.gov (United States)

    Jeon, Yun-Hee; Simpson, Judy M; Chenoweth, Lynn; Cunich, Michelle; Kendig, Hal

    2013-10-25

    A plethora of observational evidence exists concerning the impact of management and leadership on workforce, work environment, and care quality. Yet, no randomised controlled trial has been conducted to test the effectiveness of leadership and management interventions in aged care. An innovative aged care clinical leadership program (Clinical Leadership in Aged Care--CLiAC) was developed to improve managers' leadership capacities to support the delivery of quality care in Australia. This paper describes the study design of the cluster randomised controlled trial testing the effectiveness of the program. Twenty-four residential and community aged care sites were recruited as managers at each site agreed in writing to participate in the study and ensure that leaders allocated to the control arm would not be offered the intervention program. Sites undergoing major managerial or structural changes were excluded. The 24 sites were randomly allocated to receive the CLiAC program (intervention) or usual care (control), stratified by type (residential vs. community, six each for each arm). Treatment allocation was masked to assessors and staff of all participating sites. The objective is to establish the effectiveness of the CLiAC program in improving work environment, workforce retention, as well as care safety and quality, when compared to usual care. The primary outcomes are measures of work environment, care quality and safety, and staff turnover rates. Secondary outcomes include manager leadership capacity, staff absenteeism, intention to leave, stress levels, and job satisfaction. Differences between intervention and control groups will be analysed by researchers blinded to treatment allocation using linear regression of individual results adjusted for stratification and clustering by site (primary analysis), and additionally for baseline values and potential confounders (secondary analysis). Outcomes measured at the site level will be compared by cluster

  3. The effectiveness of an aged care specific leadership and management program on workforce, work environment, and care quality outcomes: design of a cluster randomised controlled trial

    Science.gov (United States)

    2013-01-01

    Background A plethora of observational evidence exists concerning the impact of management and leadership on workforce, work environment, and care quality. Yet, no randomised controlled trial has been conducted to test the effectiveness of leadership and management interventions in aged care. An innovative aged care clinical leadership program (Clinical Leadership in Aged Care − CLiAC) was developed to improve managers’ leadership capacities to support the delivery of quality care in Australia. This paper describes the study design of the cluster randomised controlled trial testing the effectiveness of the program. Methods Twenty-four residential and community aged care sites were recruited as managers at each site agreed in writing to participate in the study and ensure that leaders allocated to the control arm would not be offered the intervention program. Sites undergoing major managerial or structural changes were excluded. The 24 sites were randomly allocated to receive the CLiAC program (intervention) or usual care (control), stratified by type (residential vs. community, six each for each arm). Treatment allocation was masked to assessors and staff of all participating sites. The objective is to establish the effectiveness of the CLiAC program in improving work environment, workforce retention, as well as care safety and quality, when compared to usual care. The primary outcomes are measures of work environment, care quality and safety, and staff turnover rates. Secondary outcomes include manager leadership capacity, staff absenteeism, intention to leave, stress levels, and job satisfaction. Differences between intervention and control groups will be analysed by researchers blinded to treatment allocation using linear regression of individual results adjusted for stratification and clustering by site (primary analysis), and additionally for baseline values and potential confounders (secondary analysis). Outcomes measured at the site level will be

  4. Ethnic-specific perceptions of altered control among American women: implications for health promotion programs after pregnancy.

    Science.gov (United States)

    Sterling, Bobbie; Fowles, Eileen; Kim, Sunghun; Latimer, Lara; Walker, Lorraine O

    2011-01-01

    This study describes some ethnically diverse psychosocial and behavioral contexts that influence low-income postpartum women's ability to focus on their health. Content analysis was conducted on data from ethnically concordant focus groups of low-income American Anglo, African American, and Hispanic women 12 to 24 months postpartum. All women described altered sense of "perceived control" as the context contributing to their postpartum health status, but sources and management of this perception varied by ethnicity. Effective health promotion interventions may include self-image building activities, stress management strategies and interventions that include family members but should address unique ethnic-specific contexts of low-income mothers.

  5. Parental concerns about complementary feeding

    DEFF Research Database (Denmark)

    Nielsen, Annemette; Michaelsen, Kim F.; Holm, Lotte

    2013-01-01

    of the family's food, and the mother's focus was on the immediate well-being and safety of the child. In the later phase, health concerns shifted towards a longer-term perspective, and the aim of integrating the child into the family's social world became as important as concerns about well-being and safety......Background/objectives:To investigate and analyze differences in parental concerns during earlier and later phases of complementary feeding.Subject/methods:Eight focus group interviews were conducted with 45 mothers of children aged 7 or 13 months. Deductive and inductive coding procedures were...

  6. Newton/Poisson-Distribution Program

    Science.gov (United States)

    Bowerman, Paul N.; Scheuer, Ernest M.

    1990-01-01

    NEWTPOIS, one of two computer programs making calculations involving cumulative Poisson distributions. NEWTPOIS (NPO-17715) and CUMPOIS (NPO-17714) used independently of one another. NEWTPOIS determines Poisson parameter for given cumulative probability, from which one obtains percentiles for gamma distributions with integer shape parameters and percentiles for X(sup2) distributions with even degrees of freedom. Used by statisticians and others concerned with probabilities of independent events occurring over specific units of time, area, or volume. Program written in C.

  7. Root exudation of phytochemicals in Arabidopsis follows specific patterns that are developmentally programmed and correlate with soil microbial functions.

    Directory of Open Access Journals (Sweden)

    Jacqueline M Chaparro

    Full Text Available Plant roots constantly secrete compounds into the soil to interact with neighboring organisms presumably to gain certain functional advantages at different stages of development. Accordingly, it has been hypothesized that the phytochemical composition present in the root exudates changes over the course of the lifespan of a plant. Here, root exudates of in vitro grown Arabidopsis plants were collected at different developmental stages and analyzed using GC-MS. Principle component analysis revealed that the composition of root exudates varied at each developmental stage. Cumulative secretion levels of sugars and sugar alcohols were higher in early time points and decreased through development. In contrast, the cumulative secretion levels of amino acids and phenolics increased over time. The expression in roots of genes involved in biosynthesis and transportation of compounds represented in the root exudates were consistent with patterns of root exudation. Correlation analyses were performed of the in vitro root exudation patterns with the functional capacity of the rhizosphere microbiome to metabolize these compounds at different developmental stages of Arabidopsis grown in natural soils. Pyrosequencing of rhizosphere mRNA revealed strong correlations (p<0.05 between microbial functional genes involved in the metabolism of carbohydrates, amino acids and secondary metabolites with the corresponding compounds released by the roots at particular stages of plant development. In summary, our results suggest that the root exudation process of phytochemicals follows a developmental pattern that is genetically programmed.

  8. Root Exudation of Phytochemicals in Arabidopsis Follows Specific Patterns That Are Developmentally Programmed and Correlate with Soil Microbial Functions

    Science.gov (United States)

    Sugiyama, Akifumi; Manter, Daniel K.; Vivanco, Jorge M.

    2013-01-01

    Plant roots constantly secrete compounds into the soil to interact with neighboring organisms presumably to gain certain functional advantages at different stages of development. Accordingly, it has been hypothesized that the phytochemical composition present in the root exudates changes over the course of the lifespan of a plant. Here, root exudates of in vitro grown Arabidopsis plants were collected at different developmental stages and analyzed using GC-MS. Principle component analysis revealed that the composition of root exudates varied at each developmental stage. Cumulative secretion levels of sugars and sugar alcohols were higher in early time points and decreased through development. In contrast, the cumulative secretion levels of amino acids and phenolics increased over time. The expression in roots of genes involved in biosynthesis and transportation of compounds represented in the root exudates were consistent with patterns of root exudation. Correlation analyses were performed of the in vitro root exudation patterns with the functional capacity of the rhizosphere microbiome to metabolize these compounds at different developmental stages of Arabidopsis grown in natural soils. Pyrosequencing of rhizosphere mRNA revealed strong correlations (proots at particular stages of plant development. In summary, our results suggest that the root exudation process of phytochemicals follows a developmental pattern that is genetically programmed. PMID:23383346

  9. The resistance evaluation: Effects of a specific training program on professional fire-fighter cardio-respiratory fitness

    Directory of Open Access Journals (Sweden)

    P.J. Mourão

    2008-01-01

    Full Text Available The fire-fighters have an increased risk for developing cardiac pathologies and also a higher index of premature death than other individuals that perform high risk jobs. In this way, low physical fitness obviously limits fire-fighter performance, as well as degrades their health. However this fact not only damages the individual fire-fighter but also the institution that he represents hence severely questioning property and general public safety. The cardio-respiratory fitness had been identify as the most important physical fitness component. In this way, we developed a 12 weeks training program, to improve the cardio-respiratory fitness in a Professional fire-fighters corporation. According to reference values, before training these fire-fighters did not have enough cardio-respiratory fitness to adequately perform their job requirements with efficacy and safety (VO2máx=44,17ml/kg/min. However after training there was great improvement (VO2máx=52,69 ml/kg/min, providing a safe and more qualified service for the general population.

  10. Consumer concerns: motivating to action.

    OpenAIRE

    Bruhn, C. M.

    1997-01-01

    Microbiologic safety is consumers' most frequently volunteered food safety concern. An increase in the level of concern in recent years suggests that consumers are more receptive to educational information. However, changing lifestyles have lessened the awareness of foodborne illness, especially among younger consumers. Failure to fully recognize the symptoms or sources of foodborne disease prevents consumers from taking corrective action. Consumer education messages should include the ubiqui...

  11. Women trafficking: causes, concerns, care!

    Science.gov (United States)

    Khowaja, Shaneela Sadaruddin; Tharani, Ambreen Jawed; Agha, Ajmal; Karamaliani, Rozina Sherali

    2012-08-01

    Pakistan is both a country of origin and destination as far as women trafficking is concerned. Poverty, gender discrimination, lack of education, and ignorance about legal rights are some of the underlying causes. Available data suggest several areas of concern, like, for instance: direct health effects, maladaptive coping leading to the use of illicit drugs, and inaccessibility to healthcare facilities. Therefore, numerous interventions would be required at three levels: the prevention of trafficking, the protection of victims and the prosecution of the traffickers.

  12. Course and prognosis of recovery for chronic non-specific low back pain: design, therapy program and baseline data of a prospective cohort study

    Directory of Open Access Journals (Sweden)

    Verkerk Karin

    2011-11-01

    Full Text Available Abstract Background There has been increasing focus on factors predicting the development of chronic musculoskeletal disorders. For patients already experiencing chronic non-specific low back pain it is also relevant to investigate which prognostic factors predict recovery. We present the design of a cohort study that aims to determine the course and prognostic factors for recovery in patients with chronic non-specific low back pain. Methods/Design All participating patients were recruited (Jan 2003-Dec 2008 from the same rehabilitation centre and were evaluated by means of (postal questionnaires and physical examinations at baseline, during the 2-month therapy program, and at 5 and 12 months after start of therapy. The therapy protocol at the rehabilitation centre used a bio-psychosocial approach to stimulate patients to adopt adequate (movement behaviour aimed at physical and functional recovery. The program is part of regular care and consists of 16 sessions of 3 hours each, over an 8-week period (in total 48 hours, followed by a 3-month self-management program. The primary outcomes are low back pain intensity, disability, quality of life, patient's global perceived effect of recovery, and participation in work. Baseline characteristics include information on socio-demographics, low back pain, employment status, and additional clinical items status such as fatigue, duration of activities, and fear of kinesiophobia. Prognostic variables are determined for recovery at short-term (5 months and long-term (12 months follow-up after start of therapy. Discussion In a routine clinical setting it is important to provide patients suffering from chronic non-specific low back pain with adequate information about the prognosis of their complaint.

  13. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.

    Directory of Open Access Journals (Sweden)

    Jen-Tsan Chi

    2007-09-01

    Full Text Available Smooth muscle is present in a wide variety of anatomical locations, such as blood vessels, various visceral organs, and hair follicles. Contraction of smooth muscle is central to functions as diverse as peristalsis, urination, respiration, and the maintenance of vascular tone. Despite the varied physiological roles of smooth muscle cells (SMCs, we possess only a limited knowledge of the heterogeneity underlying their functional and anatomic specializations. As a step toward understanding the intrinsic differences between SMCs from different anatomical locations, we used DNA microarrays to profile global gene expression patterns in 36 SMC samples from various tissues after propagation under defined conditions in cell culture. Significant variations were found between the cells isolated from blood vessels, bronchi, and visceral organs. Furthermore, pervasive differences were noted within the visceral organ subgroups that appear to reflect the distinct molecular pathways essential for organogenesis as well as those involved in organ-specific contractile and physiological properties. Finally, we sought to understand how this diversity may contribute to SMC-involving pathology. We found that a gene expression signature of the responses of vascular SMCs to serum exposure is associated with a significantly poorer prognosis in human cancers, potentially linking vascular injury response to tumor progression.

  14. Linking specification to differentiation

    Science.gov (United States)

    zur Lage, Petra I; Simpson, T Ian

    2011-01-01

    Much of developmental biology is concerned with the processes by which cells become committed to particular fates in a regulated fashion, whereas cell biology addresses, among other things, the variety of differentiated forms and functions that cells can acquire. One open question is how the regulators of the former process lead to attainment of the latter. “High-level” regulators of cell fate specification include the proneural factors, which drive cells to commit as precursors in the sensory nervous system. Recent research has concentrated on the gene expression events downstream of proneural factor function. Here we summarize this research and describe our own research that has provided clear links between a proneural factor, atonal and the cell biological program of ciliogenesis, which is a central aspect of sensory neuron differentiation. PMID:21558799

  15. Strategy and research programs on the long life high activity radioactive wastes management (concerning the article L542 of the environment code, of the law of the 30 December 1991). Knowledge and perspectives; Strategie et programmes des recherches sur la gestion des dechets radioactifs a haute activite et a vie longue (au titre de l'article L542 du code de l'environnement, issu de la loi du 30 decembre 1991). Acquis et perspectives

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    Describing the research strategy and the programs around the three axis, separation and transmutation - deep underground storage - conditioning and long time disposal, this document is a reference concerning the research programs of the law of the 30 December 1991. This 2004 edition presents the historical approach and the main context, the objectives, the methods and criteria followed, the research program organization and implemented coordination structures. It provides also the results of the last ten years. (A.L.B.)

  16. Measurement of functional capacity requirements to aid in development of an occupation-specific rehabilitation training program to help firefighters with cardiac disease safely return to work.

    Science.gov (United States)

    Adams, Jenny; Roberts, Joanne; Simms, Kay; Cheng, Dunlei; Hartman, Julie; Bartlett, Charles

    2009-03-15

    We designed a study to measure the functional capacity requirements of firefighters to aid in the development of an occupation-specific training program in cardiac rehabilitation; 23 healthy male firefighters with no history of heart disease completed a fire and rescue obstacle course that simulated 7 common firefighting tasks. They wore complete personal protective equipment and portable metabolic instruments that included a data collection mask. We monitored each subject's oxygen consumption (VO(2)) and working heart rate, then calculated age-predicted maximum heart rates (220 - age) and training target heart rates (85% of age-predicted maximum heart rate). During performance of the obstacle course, the subjects' mean working heart rates and peak heart rates were higher than the calculated training target heart rates (t(22) = 5.69 [working vs target, p <0.001] and t(22) = 15.14 [peak vs target, p <0.001]). These findings, with mean results for peak VO(2) (3,447 ml/min) and metabolic equivalents (11.9 METs), show that our subjects' functional capacity greatly exceeded that typically attained by patients in traditional cardiac rehabilitation programs (5 to 8 METs). In conclusion, our results indicate the need for intense, occupation-specific cardiac rehabilitation training that will help firefighters safely return to work after a cardiac event.

  17. Globalization and new policy concerns

    DEFF Research Database (Denmark)

    Daugbjerg, Carsten; Swinbank, Alan

    2015-01-01

    The transfer of some decision-making authority from the domestic to the supranational arena as a result of the establishment of the World Trade Organization (WTO) in 1995 potentially changed domestic policy dynamics. The WTO agreements reflect the trade policy concerns addressed in the Uruguay...... Round in the late 1980s and early 1990s. This article applies and adapts historical institutionalism to explain how international organizations may constrain and facilitate certain domestic policy options. It demonstrates that, while the WTO legal framework has become more receptive of environmental...... sustainability concerns, the social sustainability concerns that were increasingly entering the debate over biofuel policies were not easily accommodated, and this was seen as a constraint on the content of the European Union's (EU) policy adopted in 2009. Only the environmental dimension of a broader concept...

  18. Comparison of In-Season-Specific Resistance vs. A Regular Throwing Training Program on Throwing Velocity, Anthropometry, and Power Performance in Elite Handball Players.

    Science.gov (United States)

    Hermassi, Souhail; van den Tillaar, Roland; Khlifa, Riadh; Chelly, Mohamed Souhaiel; Chamari, Karim

    2015-08-01

    The purpose of this study was to compare the effect of a specific resistance training program (throwing movement with a medicine ball) with that of regular training (throwing with regular balls) on ball velocity, anthropometry, maximal upper-body strength, and power. Thirty-four elite male team handball players (age: 18 ± 0.5 years, body mass: 80.6 ± 5.5 kg, height: 1.80 ± 5.1 m, body fat: 13.4 ± 0.6%) were randomly assigned to 1 of the 3 groups: control (n = 10), resistance training group (n = 12), or regular throwing training group (n = 12). Over the 8-week in season, the athletes performed 3 times per week according to an assigned training program alongside their normal team handball training. One repetition maximum (1RM) bench press and 1RM pullover scores assessed maximal arm strength. Anthropometry was assessed by body mass, fat percentage, and muscle volumes of upper body. Handball throwing velocity was measured by a standing throw, a throw with run, and a jump throw. Power was measured by measuring total distance thrown by a 3-kg medicine ball overhead throw. Throwing ball velocity, maximal strength, power, and muscle volume increases for the specific resistance training group after the 8 weeks of training, whereas only maximal strength, muscle volume and power and in the jump throw increases were found for the regular throwing training group. No significant changes for the control group were found. The current findings suggest that elite male handball players can improve ball velocity, anthropometrics, maximal upper-body strength, and power during the competition season by implementing a medicine ball throwing program.

  19. Legal and social concerns to the development of bioremediation technologies

    Energy Technology Data Exchange (ETDEWEB)

    Bilyard, G.R.; McCabe, G.H.; White, K.A.; Gajewski, S.W.; Hendrickson, P.L.; Jaksch, J.A.; Kirwan-Taylor, H.A.; McKinney, M.D.

    1996-09-01

    The social and legal framework within which bioremediation technologies must be researched, developed, and deployed in the US are discussed in this report. Discussions focus on policies, laws and regulations, intellectual property, technology transfer, and stakeholder concerns. These discussions are intended to help program managers, scientists and engineers understand the social and legal framework within which they work, and be cognizant of relevant issues that must be navigated during bioremediation technology research, development, and deployment activities. While this report focuses on the legal and social environment within which the DOE operates, the laws, regulations and social processes could apply to DoD and other sites nationwide. This report identifies specific issues related to bioremediation technologies, including those involving the use of plants; native, naturally occurring microbes; non-native, naturally occurring microbes; genetically engineered organisms; and microbial products (e.g., enzymes, surfactants, chelating compounds). It considers issues that fall within the following general categories: US biotechnology policy and the regulation of field releases of organisms; US environmental laws and waste cleanup regulations; intellectual property and patenting issues; technology transfer procedures for commercializing technology developed through government-funded research; stakeholder concerns about bioremediation proposals; and methods for assuring public involvement in technology development and deployment.

  20. "Peer Pressure" and the Group Process: Building Cultures of Concern

    Science.gov (United States)

    Tate, Thomas F.; Copas, Randall L.

    2010-01-01

    Peer group treatment has been subject to two main lines of criticism. Some suggest any program which aggregates antisocial youth inevitably fosters negative peer influence. Others are concerned that certain peer programs are based on coercive peer confrontation. Positive Peer Culture [PPC] is an antidote to both of these varieties of toxic group…

  1. Erreichbarkeit Jugendlicher für ein Internet- und SMS-Programm zum Thema Alkohol [Accessibility of Adolescents for an Internet- and Text Message-Based Program Concerning Alcohol Abuse

    OpenAIRE

    Haug Severin; Paz Castro Raquel; Schaub Michael Patrick

    2015-01-01

    Abstract: Aims: Internet and text messaging based interventions open up the possibility to motivate adolescents via individually tailored messages to drink within low risk limits. The school setting is particularly suited for the recruitment of large populations of adolescents for such interventions. We investigated the influence of individual school class and school specific characteristics on participation in an internet and text messaging based intervention to reduce problem drinking. ...

  2. Can a disease-specific education program augment self-management skills and improve Health-Related Quality of Life in people with hip or knee osteoarthritis?

    Directory of Open Access Journals (Sweden)

    Buchbinder Rachelle

    2006-11-01

    Full Text Available Abstract Background Patient education and self-management programs are offered in many countries to people with chronic conditions such as osteoarthritis (OA. The most well-known is the disease-specific Stanford Arthritis Self-Management Program (ASMP. While Australian and international clinical guidelines promote the concept of self-management for OA, there is currently little evidence to support the use of the ASMP. Several meta-analyses have reported that arthritis self-management programs had minimal or no effect on reducing pain and disability. However, previous studies have had methodological shortcomings including the use of outcome measures which do not accurately reflect program goals. Additionally, limited cost-effectiveness analyses have been undertaken and the cost-utility of the program has not been explored. Methods/design This study is a randomised controlled trial to determine the efficacy (in terms of Health-Related Quality of Life and self-management skills and cost-utility of a 6-week group-based Stanford ASMP for people with hip or knee OA. Six hundred participants referred to an orthopaedic surgeon or rheumatologist for hip or knee OA will be recruited from outpatient clinics at 2 public hospitals and community-based private practices within 2 private hospital settings in Victoria, Australia. Participants must be 18 years or over, fluent in English and able to attend ASMP sessions. Exclusion criteria include cognitive dysfunction, previous participation in self-management programs and placement on a waiting list for joint replacement surgery or scheduled joint replacement. Eligible, consenting participants will be randomised to an intervention group (who receive the ASMP and an arthritis self-management book or a control group (who receive the book only. Follow-up will be at 6 weeks, 3 months and 12 months using standardised self-report measures. The primary outcome is Health-Related Quality of Life at 12 months, measured

  3. School Safety Concerns All Students.

    Science.gov (United States)

    Henderson, Megan

    1999-01-01

    Suggests that school safety is an issue that concerns all students. Discusses how the staff of the Rockwood South (Missouri) "RAMpage" covered the shootings at Columbine High School in a 14-page issue and in follow-up issues. Suggests that the student newspaper covered the controversial topic in an appropriate, tasteful manner. (RS)

  4. Privacy concerns in smart cities

    NARCIS (Netherlands)

    E.A. van Zoonen (Liesbet)

    2016-01-01

    textabstractIn this paper a framework is constructed to hypothesize if and how smart city technologies and urban big data produce privacy concerns among the people in these cities (as inhabitants, workers, visitors, and otherwise). The framework is built on the basis of two recurring dimensions in

  5. Preliminary recommendations on the design of the characterization program for the Hanford Site single-shell tanks: A system analysis. Volume 2, Closure-related analyte priorities, concentration thresholds, and detection limit goals based on public health concerns

    Energy Technology Data Exchange (ETDEWEB)

    Buck, J.W.; Peffers, M.S.; Hwang, S.T.

    1991-11-01

    The work described in this volume was conducted by Pacific Northwest Laboratory to provide preliminary recommendations on data quality objectives (DQOs) to support the Waste Characterization Plan (WCP) and closure decisions for the Hanford Site single-shell tanks (SSTs). The WCP describes the first of a two-phase characterization program that will obtain information to assess and implement disposal options for SSTs. This work was performed for the Westinghouse Hanford Company (WHC), the current operating contractor on the Hanford Site. The preliminary DQOs contained in this volume deal with the analysis of SST wastes in support of the WCP and final closure decisions. These DQOs include information on significant contributors and detection limit goals (DLGs) for SST analytes based on public health risk.

  6. 12 CFR 13.100 - Obligations concerning institutional customers.

    Science.gov (United States)

    2010-01-01

    ... experience of the institutional customer in financial markets and specific experience with the type of... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Obligations concerning institutional customers... GOVERNMENT SECURITIES SALES PRACTICES Interpretations § 13.100 Obligations concerning institutional customers...

  7. 12 CFR 208.101 - Obligations concerning institutional customers.

    Science.gov (United States)

    2010-01-01

    ... experience of the institutional customer in financial markets and specific experience with the type of... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Obligations concerning institutional customers...) Interpretations § 208.101 Obligations concerning institutional customers. (a) As a result of broadened authority...

  8. Electroconvulsive therapy teaching in Canada: cause for concern.

    Science.gov (United States)

    Patry, Simon; Graf, Peter; Delva, Nicholas John; Chan, Peter; Enns, Murray; Gilron, Ian; Gosselin, Caroline; Jewell, Mark; Lawson, James Stuart; Martin, Barry; Milev, Roumen

    2013-06-01

    The objective of this study was to present survey data on the teaching of electroconvulsive therapy (ECT) in health care centers across Canada. Of 1273 centers identified, 175 were found to practice ECT. These centers were asked to complete a questionnaire, and 107 (61%) of them answered 5 questions dealing specifically with ECT teaching. These questions were as follows: (1) Does your facility have an ECT teaching program for residents in psychiatry? (2) How is ECT taught to residents in psychiatry? (3) If direct supervision of the administration of ECT is a requirement of the psychiatry training program, is there a minimum number of supervised treatments or minimum duration of training period? (4) Do residents provide unsupervised ECT at your center? (5) Which other groups of learners, if any, are provided with orientation, teaching, or training in ECT? Sixty percent of respondents had no ECT teaching program for psychiatry residents. Pedagogical methods varied, ranging from direct observation of ECT treatments to directed readings. Few centers required a minimum number of supervised treatments. No resident-administered ECT is performed without direct supervision. Interestingly, various groups of health care professionals were often invited to participate in ECT training. The situation regarding ECT teaching continues to be a cause for concern given the noted absence of organized, structured, and mandatory programs. No resident administering ECT, however, goes unsupervised, which is in keeping with good practice. Electroconvulsive therapy is taught in many different ways, and teaching is accessible to different groups of health care professionals. However, much remains to be done to standardize ECT teaching to render this therapy available to all those who need it and to overcome the stigma and bias associated with it.

  9. Clinical status of a cohort of patients with type 1 diabetes diagnosed more than 2 decades before. Results of a specific clinical follow-up program.

    Science.gov (United States)

    Amor, Antonio J; Cabrer, Maria; Giménez, Marga; Vinagre, Irene; Ortega, Emilio; Conget, Ignacio

    2016-01-01

    The clinical course of type 1 diabetes mellitus (T1DM) has changed in recent decades. The aim of our study was to assess the long-term (> 20 years) clinical status of a patient cohort with T1DM under a specific treatment and follow-up program. A single center, observational, cross-sectional study was conducted of a patient cohort diagnosed with T1DM in the 1986-1994 period at our tertiary university hospital. Clinical characteristics, metabolic parameters, and occurrence of chronic complications and comorbidities after > 20 years of follow-up were collected. All subjects entered our specific program for patients with newly-diagnosed T1D and were followed up using the same clinical protocol. Data are shown as mean (standard deviation) or as number of patients and percentage. The appropriate test was used to compare quantitative and qualitative data. A P value <0.05 was considered statistically significant. A total of 279 patients were recorded, of whom 153 (53.6% women; mean age 46.6±8.6 years; age at onset 23.3±8.8 years; disease duration, 23.3±2.6 years) continued to attend our diabetes unit at the time of the analysis. Of these patients, 24.8% were administered continuous subcutaneous insulin infusion (CSII). Mean HbA1c in the past 5 years and in the last year were7.8±0.9% and 7.7±1.1% respectively (7.3±1.5% in those given CSII). Smoking was reported by 19.6% of patients, while 15.7% had high blood pressure and 37.9% dyslipidemia. Diabetic retinopathy was diagnosed in 20.4%, and 11.3% of the total cohort had nephropathy. Only 1.3% of our patients had a history of CVD. Data collected from a cohort of patients with T1DM for more than 2 decades regularly followed up with a specific program in a tertiary university hospital suggest a remarkably low prevalence of diabetic complications. Copyright © 2016 SEEN. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Montana National Wildlife Refuges: Contaminant issues of concern

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to: (1) identify specific contaminant issues of concern for each Montana refuge and wetland management district; (2) summarize the...

  11. Specification and resolution of complex manipulation tasks. Application to remote robots tele-programming; Specification et resolution de taches de manipulation complexes. Application a la teleprogrammation de robots distants

    Energy Technology Data Exchange (ETDEWEB)

    Piccin, O

    1995-11-15

    The work presented in this thesis comes within the scope of remote manipulation with restricted communication properties between the operator and the remote site. This context renders traditional tele-operation infeasible. To enhance the autonomy of the remote manipulator, it is necessary to reason on a model of the robot and its workspace. However, discrepancies between the real world and its representation require calibration capabilities to identify both position and size of objects interacting with the robot. Moreover, the non-repetitiveness and complexity of the tasks demand that the specification system remains easy to re-program and capable of treating a wide range of problems. The proposed constraint-based approach permits the specification of complex manipulation tasks in which tasks' objectives are expressed in terms of mobilities and contact relationships to achieve or maintain between parts. The resulting constraint relationships are then treated by a numerical solver based on a Newton-Raphson scheme. An enhanced robustness has been achieved through a dynamic management of equations' conditioning. This enables the system to choose automatically for the most appropriate resolution scenario. The first main class of applications is complex motion generation for any kind of robotic mechanisms possibly including redundancy. Constraints setting can also be exploited to realize local obstacle avoidance. The proposed approach makes it possible to deal with calibration tasks within the same framework. This constitutes an essential feature in the context of remote manipulation where models are un-precisely known. Lastly, a weld line inspection experiment performed on a real manipulator allows us to put forward a strategy for robotic task performance at a remote location. (author)

  12. Reputational concerns with altruistic providers.

    Science.gov (United States)

    Olivella, Pau; Siciliani, Luigi

    2017-09-01

    We study a model of reputational concerns when doctors differ in their degree of altruism and they can signal their altruism by their (observable) quality. When reputational concerns are high, following the introduction or enhancement of public reporting, the less altruistic (bad) doctor mimics the more altruistic (good) doctor. Otherwise, either a separating or a semi-separating equilibrium arises: the bad doctor mimics the good doctor with probability less than one. Pay-for-performance incentive schemes are unlikely to induce crowding out, unless some dimensions of quality are unobservable. Under the pooling equilibrium a purchaser can implement the first-best quality by appropriately choosing a simple payment scheme with a fixed price per unit of quality provided. This is not the case under the separating equilibrium. Therefore, policies that enhance public reporting complement pay-for-performance schemes. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Terrorism Risk Concern in Europe

    OpenAIRE

    Drakos, Konstantinos; Müller, Cathérine

    2010-01-01

    We explore whether differences of terrorism risk perception across all European countries reflect their underlying differences in terrorism risk, which we decompose into a long term and innovation component. We employ longitudinal country-level data on terrorism risk concern and our modeling approach is motivated by the Bayesian framework. We conclude that the observed risk perception variation is significantly explained by the long term terrorism countries face, while the cyclical part of te...

  14. The long-term lasting effectiveness on self-efficacy, attribution style, expression of emotions and quality of life of a body awareness program for chronic a-specific psychosomatic symptoms

    NARCIS (Netherlands)

    Landsman-Dijkstra, Jeanet J. A.; van Wijck, R; Groothoff, JW

    Objective: A 3-day residential body awareness program (BAP) was developed to teach people with chronic a-specific psychosomatic symptoms (CAPS) to react adequately to disturbances of the balance between a daily workload and the capacity to deal with it. The long-term effects of the program on body

  15. The effect of group mindfulness - based stress reduction program and conscious yoga on the fatigue severity and global and specific life quality in women with breast cancer.

    Science.gov (United States)

    Rahmani, Soheila; Talepasand, Siavash

    2015-01-01

    Cancer is not merely an event with a certain end, but it is a permanent and vague situation that is determined by delayed effects due to the disease, its treatment and its related psychological issues. The aim of this study was to examine the effectiveness of the mindfulness-based stress reduction program and conscious yoga on the mental fatigue severity and life quality of women with breast cancer. This was a quasi-experimental study with a pre-test, post-test and control group. In this study, 24 patients with the diagnosis of breast cancer were selected among the patients who referred to the Division of Oncology and Radiotherapy of Imam Hossein hospital in Tehran using available sampling method, and were randomly assigned into the experimental and control groups. All the participants completed the Fatigue Severity Scale, Global Life Quality of Cancer Patient and Specific Life Quality of Cancer Patient questionnaires. Data were analyzed by multivariate repeated measurement variance analysis model. Findings revealed that the mindfulness-based stress reduction treatment significantly improved the overall quality of life, role, cognitive, emotion, social functions and pain and fatigue symptoms in global life quality in the experimental group. It also significantly improved the body image, future functions and therapy side effects in specific life quality of the experimental group compared to the control group. In addition, fatigue severity caused by cancer was reduced significantly. The results showed that the mindfulness - based stress reduction treatment can be effective in improving global and specific life quality and fatigue severity in women with breast cancer.

  16. Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression.

    Science.gov (United States)

    Schwarz, Jaclyn M; Hutchinson, Mark R; Bilbo, Staci D

    2011-12-07

    A critical component of drug addiction research involves identifying novel biological mechanisms and environmental predictors of risk or resilience to drug addiction and associated relapse. Increasing evidence suggests microglia and astrocytes can profoundly affect the physiological and addictive properties of drugs of abuse, including morphine. We report that glia within the rat nucleus accumbens (NAcc) respond to morphine with an increase in cytokine/chemokine expression, which predicts future reinstatement of morphine conditioned place preference (CPP) following a priming dose of morphine. This glial response to morphine is influenced by early-life experience. A neonatal handling paradigm that increases the quantity and quality of maternal care significantly increases baseline expression of the anti-inflammatory cytokine IL-10 within the NAcc, attenuates morphine-induced glial activation, and prevents the subsequent reinstatement of morphine CPP in adulthood. IL-10 expression within the NAcc and reinstatement of CPP are negatively correlated, suggesting a protective role for this specific cytokine against morphine-induced glial reactivity and drug-induced reinstatement of morphine CPP. Neonatal handling programs the expression of IL-10 within the NAcc early in development, and this is maintained into adulthood via decreased methylation of the IL-10 gene specifically within microglia. The effect of neonatal handling is mimicked by pharmacological modulation of glia in adulthood with ibudilast, which increases IL-10 expression, inhibits morphine-induced glial activation within the NAcc, and prevents reinstatement of morphine CPP. Taken together, we have identified a novel gene × early-life environment interaction on morphine-induced glial activation and a specific role for glial activation in drug-induced reinstatement of drug-seeking behavior.

  17. Symmetry Concerns as a Symptom of Body Dysmorphic Disorder.

    Science.gov (United States)

    Hart, Ashley S; Phillips, Katharine A

    2013-07-01

    Symmetry obsessions are a common symptom of obsessive-compulsive disorder (OCD) and have several demographic and clinical correlates. Appearance-related symmetry concerns appear common in body dysmorphic disorder (BDD); however, no published studies have examined this topic. This study examined the clinical features, prevalence, and correlates of symmetry concerns involving physical appearance in two BDD samples (N=160 and N=115). More than 25% of participants in each sample reported symmetry concerns for a body part with which they were preoccupied (total of 18 body parts in sample 1 and 18 in sample 2). In sample 1, BDD participants with appearance-related symmetry concerns were older than those without appearance-related symmetry concerns. In sample 2, those with appearance-related symmetry concerns reported poorer mental health-related quality of life, were more likely to have experienced lifetime suicidal ideation, had better BDD-related insight, and were less likely to have a lifetime eating disorder. In both samples, participants with appearance-related symmetry concerns were more likely to have lifetime OCD but not OCD-related symmetry obsessions. Thus, symmetry is a common appearance concern in BDD that is associated with comorbid OCD but not with OCD symmetry concerns specifically, suggesting that symmetry concerns may have a different mechanism/pathophysiology in BDD versus OCD.

  18. Consumer concerns: motivating to action.

    Science.gov (United States)

    Bruhn, C. M.

    1997-01-01

    Microbiologic safety is consumers' most frequently volunteered food safety concern. An increase in the level of concern in recent years suggests that consumers are more receptive to educational information. However, changing lifestyles have lessened the awareness of foodborne illness, especially among younger consumers. Failure to fully recognize the symptoms or sources of foodborne disease prevents consumers from taking corrective action. Consumer education messages should include the ubiquity of microorganisms, a comprehensive description of foodborne illnesses, and prevention strategies. Product labels should contain food-handling information and warnings for special populations, and foods processed by newer safety-enhancing technologies should be more widely available. Knowledge of the consequences of unsafe practices can enhance motivation and adherence to safety guidelines. When consumers mishandle food during preparation, the health community, food industry, regulators, and the media are ultimately responsible. Whether inappropriate temperature control, poor hygiene, or another factor, the error occurs because consumers have not been informed about how to handle food and protect themselves. The food safety message has not been delivered effectively. PMID:9366604

  19. Measurement of functional capacity requirements of police officers to aid in development of an occupation-specific cardiac rehabilitation training program.

    Science.gov (United States)

    Adams, Jenny; Schneider, Jonna; Hubbard, Matthew; McCullough-Shock, Tiffany; Cheng, Dunlei; Simms, Kay; Hartman, Julie; Hinton, Paul; Strauss, Danielle

    2010-01-01

    This study was designed to measure the functional capacity of healthy subjects during strenuous simulated police tasks, with the goal of developing occupation-specific training for cardiac rehabilitation of police officers. A calibrated metabolic instrument and an oxygen consumption data collection mask were used to measure the oxygen consumption and heart rates of 30 Dallas Police Academy officers and cadets as they completed an 8-event obstacle course that simulated chasing, subduing, and handcuffing a suspect. Standard target heart rates (85% of age-predicted maximum heart rate, or 0.85 x [220 - age]) and metabolic equivalents (METs) were calculated; a matched-sample t test based on differences between target and achieved heart rate and MET level was used for statistical analysis. Peak heart rates during the obstacle course simulation were significantly higher than the standard target heart rates (those at which treadmill stress tests in physicians' offices are typically stopped) (t(29) = 12.81, P maximum of 150 beats/min during cardiac rehabilitation training (t(29) = 17.84, P < 0.001). Peak MET levels during the obstacle course simulation were also significantly higher than the goal level (8 METs) that patients typically achieve in a cardiac rehabilitation program (t(29) = 14.73, P < 0.001). We conclude that police work requires a functional capacity greater than that typically attained in traditional cardiac rehabilitation programs. Rehabilitation professionals should consider performing maximal stress tests and increasing the intensity of cardiac rehabilitation workouts to effectively train police officers who have had a cardiac event.

  20. Mental health concerns among African immigrants.

    Science.gov (United States)

    Venters, Homer; Adekugbe, Olayinka; Massaquoi, Jacob; Nadeau, Cheryl; Saul, Jack; Gany, Francesca

    2011-08-01

    African immigrants represent a rapidly expanding group of immigrants in the United States. In New York City, Africans constitute the fastest growing segment of immigrants but the needs and practices of African immigrants in the U.S. remain poorly understood. A community based organization (CBO) serving African immigrants in Staten Island, NY began a health screening program in 2008 with the goal of promoting access to primary care. Over 18 months, 296 visits were recorded at African Refuge health screenings, representing a total of 87 people who averaged just over 3 visits per person. The screenings identified mental health among the top three medical problems of clients but referral to mental health services was rare. Dedicated services are required to better screen for mental health concerns and refer African immigrants to mental health care.

  1. Space resources. Volume 4: Social concerns

    Science.gov (United States)

    Mckay, Mary Fae (Editor); Mckay, David S. (Editor); Duke, Michael B. (Editor)

    1992-01-01

    Space resources must be used to support life on the Moon and exploration of Mars. This volume, Social Concerns, covers some of the most important issues which must be addressed in any major program for the human exploration of space. The volume begins with a consideration of the economics and management of large scale space activities. Then the legal aspects of these activities are discussed, particularly the interpretation of treaty law with respect to the Moon and asteroids. The social and cultural issues of moving people into space are considered in detail, and the eventual emergence of a space culture different from the existing culture is envisioned. The environmental issues raised by the development of space settlements are faced. Some innovative approaches are proposed to space communities and habitats and self-sufficiency is considered along with human safety at a lunar base or outpost.

  2. Legal concerns in psychosomatic medicine.

    Science.gov (United States)

    Brendel, Rebecca W; Schouten, Ronald

    2007-12-01

    In the practice of psychosomatic medicine, the psychiatric consultant is likely to be confronted with questions at the interface of psychiatry and law. These issues generally emerge around questions of confidentiality and exceptions to confidentiality, assessments of a patient's ability to consent to and refuse treatment, and concerns about malpractice liability. Overall, psychiatrists should approach the care of patients clinically, while understanding the applicable laws and regulations of the jurisdictions in which they practice. In addition, clinicians should be aware of the legal and risk management resources available to them should a complex situation arise. Finally, the psychiatric consultant should make use of consultation when complex issues emerge at the interface of psychiatry and law.

  3. HERBAL SUPPLEMENTS: CAUSE FOR CONCERN?

    Directory of Open Access Journals (Sweden)

    Paolo Borrione

    2008-12-01

    Full Text Available More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996. Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. Ginko biloba, horse- chestnut, and only 10% of the herbs used in nutritional supplements are commonly present in the food (e.g. garlic, soy, blueberry, green the, ginger, curcuma (Eisenberg et al., 1993. There is much interest in "alternative natural approaches" in sport. It is appealing for athletes to use 'natural' substances with similar activity to 'pharmacological' ones in term of improving performance, are not considered doping, and are considered side-effects free (Table 1. Indeed, many herbal dietary supplements marketed on internet are presented as legal alternative to illicit drugs (Denneey et al., 2005. EcdysteroidsEcdysteroids are the steroid hormones of arthropods (Figure 1. They also occur in some plants, where they are known as phytoecdysteroids, and are believed to contribute to deter invertebrate predators. In insects, they regulate moulting and metamorphosis, may regulate reproduction and diapause. Most actions of ecdysteroids are mediated by intracellular receptor complexes, which regulate gene expression in a tissue- and development-specific manner (Lehmann et al 1989.Several phytoecdysteroids have anabolic growth-promoting effects on mice, rats, pigs and Japanese quails. Ecdysteroids stimulate muscle growth, and this anabolic effect promotes increased physical performance without training. Ecdysteroids are also able to increase muscle ATP content in vitamin D-deprived rats (Báthori, 2002. Ecdysteroids stimulate protein synthesis in the

  4. An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.

    Science.gov (United States)

    Oh, Hyunju; Grinberg-Bleyer, Yenkel; Liao, Will; Maloney, Dillon; Wang, Pingzhang; Wu, Zikai; Wang, Jiguang; Bhatt, Dev M; Heise, Nicole; Schmid, Roland M; Hayden, Matthew S; Klein, Ulf; Rabadan, Raul; Ghosh, Sankar

    2017-09-19

    Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-κB. In Tconv cells, NF-κB regulates expression of genes essential for T cell activation, proliferation, and function. However the role of NF-κB in Treg function remains unclear. We conditionally deleted canonical NF-κB members p65 and c-Rel in developing and mature Treg cells and found they have unique but partially redundant roles. c-Rel was critical for thymic Treg development while p65 was essential for mature Treg identity and maintenance of immune tolerance. Transcriptome and NF-κB p65 binding analyses demonstrated a lineage specific, NF-κB-dependent transcriptional program, enabled by enhanced chromatin accessibility. These dual roles of canonical NF-κB in Tconv and Treg cells highlight the functional plasticity of the NF-κB signaling pathway and underscores the need for more selective strategies to therapeutically target NF-κB. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Current Issues Concerning Korea’s Anti-Terrorism Programs

    Science.gov (United States)

    2011-06-10

    were held hostage.32 On 21 January 2011, Korean Navy special forces from the Cheonghae Naval Unit rescued the Samho Jewelry , an 11,500-ton Korean...legislate counterterrorism laws in search of a solution to contemporary terrorist threats, Korea also made strenuous efforts to prepare against

  6. Principles of Integrating Spiritual Concerns into Programs for the Aging.

    Science.gov (United States)

    Fahey, Charles J.; Lewis, Mary Ann

    1990-01-01

    A well-rounded congregational approach to the elderly should be based on three premises: (1) older persons can give as well as receive ministry; (2) ministry should assist with aging gracefully and supporting the frail, sick, and dependent; and (3) intergenerational solidarity is to be highly valued. (SK)

  7. Nuisance Odors: Is there a Concern - 12340

    Energy Technology Data Exchange (ETDEWEB)

    Brounstein, Robert A. [TerranearPMC, Los Alamos New Mexico 87544 (United States)

    2012-07-01

    Nuisance odors are generally thought of as just being annoying or unpleasant and not causing any physiological harm to our internal organs or other biologic systems. Yet during an excavation of buried animal remains, field workers experienced a multitude of symptoms that are associated with exposures to toxic materials. An examination of the decomposition process revealed that there is a potential off-gassing of a number of common, yet harmful chemicals including ammonia, mercaptans, hydrogen sulfide, butyric acid and phenol. In addition, other compounds, that have limited information such as established health data and occupational exposure limits, were also potential contaminants-of-concern. While a variety of monitoring and sampling techniques were used to assess worker exposures, all results indicated non-detectable airborne concentrations. Nevertheless, workers were experiencing such symptoms as nausea and headaches. As such, protective measures were necessary for field personnel to continue work while having confidence that the project was instituting sincere steps to ensure their health and safety. Researching the possible reasons for the causes of workers exhibiting adverse health effects from nuisance odors revealed that such exposures initiate electrochemical pathways, starting from the olfactory bulb to the brain, followed by a transfer of information to such biologic systems as the hypothalamus and pituitary gland. These systems, in turn, secrete hormones that cause a number of involuntary reactions; many of which are observed as typical adverse health effects, when in fact, they are merely reactions caused by the brain's memory; most likely created from previous experiences to unpleasant odors. The concern then focuses of how the Occupational Safety and Health community shall respond to such workplace exposures. Future work in this area may need to focus on the viability of current occupational exposure limits and the possibility of revising these

  8. Ombuds’ corner: Confidentiality concerning boards

    CERN Multimedia

    Vincent Vuillemin

    2011-01-01

    In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity.   Phil* was a candidate for a position in a different group from the one he had been working for. After his board had taken place, Phil asked for an appointment with the Ombuds. In his opinion, the interview went reasonably well. However Phil had some concerns as he had heard that there was no point in him applying as another candidate will get the position. He had decided to apply anyway, encouraged by other people, with the hope that he would get a good rating that could help him get a position in the future, if he didn't get present one. During the interview he was asked some questions that could only have been answered by candidates with  experience related ...

  9. Sustainability concern in discourse and practice

    DEFF Research Database (Denmark)

    Petersen, Lars Kjerulf; Ferrucci, Martina

    . These factors include (according to some analytical distinctions; see Shove) the embodied competences involved in performing all practices, the meanings, i.e. norms, engagements, world views, and orientations that saturate and guide them, and the materials, i.e. artefacts, infrastructures, technologies...... and human-material interfaces through which practices are constituted and maintained, and they can help identify some of those impulses though which practices may be reconfigured – or help reveal the marginal status of pro-environmental concerns in collective meanings. We furthermore propose to apply ANT...... practices (taking the train or the car), specific tropes (“get the growth going” or “we are using more than one Earth”) and various other discursive framings. The project seeks to identify such sustainability related in-text actors and follow them within as well as outside the text and into household...

  10. Data systems and computer science: Software Engineering Program

    Science.gov (United States)

    Zygielbaum, Arthur I.

    1991-01-01

    An external review of the Integrated Technology Plan for the Civil Space Program is presented. This review is specifically concerned with the Software Engineering Program. The goals of the Software Engineering Program are as follows: (1) improve NASA's ability to manage development, operation, and maintenance of complex software systems; (2) decrease NASA's cost and risk in engineering complex software systems; and (3) provide technology to assure safety and reliability of software in mission critical applications.

  11. School Transportation Issues, Laws and Concerns: Implications for Future Administrators

    Science.gov (United States)

    Durick, Jody M.

    2010-01-01

    Nearly all building administrators are confronted with a variety of transportation issues. Challenges, concerns and questions can arise from various aspects, including student misbehaviors, transportation laws and its implications at the school level, to importance and implementation of a school bus safety program. As new and upcoming future…

  12. Models of Vocational Development Revisited: Reflecting on Concerns.

    Science.gov (United States)

    James, Pauline

    1995-01-01

    A study of adult learners in a teacher-training internship program used concerns-based and critical reflection models to demonstrate that people become reflective when current actions become inappropriate, a supportive environment for acknowledging and addressing stress is created, and thinking is challenged. (SK)

  13. A Falls Concern Scale for people with spinal cord injury (SCI-FCS).

    Science.gov (United States)

    Boswell-Ruys, C L; Harvey, L A; Delbaere, K; Lord, S R

    2010-09-01

    Observational study and cross-sectional survey. To develop a scale assessing concern about falling in people with spinal cord injuries who are dependent on manual wheelchairs, and to evaluate psychometric properties of this new scale. Community and hospitals, Australia. The Spinal Cord Injury-Falls Concern Scale (SCI-FCS) was developed in consultation with SCI professionals. The SCI-FCS addressed concern about falling during 16 activities of daily living associated with falling and specific to people with SCI. One hundred and twenty-five people with either acute or chronic SCI who used manual wheelchairs were assessed on the SCI-FCS and asked questions related to their SCI and overall physical abilities. A subgroup of 20 people was reassessed on the SCI-FCS within 7 days. The SCI-FCS had excellent internal and test-retest reliability (Cronbach's alpha=0.92, intra-class correlation coefficient (ICC)=0.93). Factor analysis revealed three underlying dimensions of the SCI-FCS addressing concern about falling during activities that limit hand support and require movement of the body's centre of mass. The discriminative ability of the SCI-FCS between different diagnostic groups indicated good construct validity. Subjects with a high level of SCI, few previous falls, dependence in vertical transfers and poor perceived sitting ability demonstrated high levels of concern about falling. This study suggests that the SCI-FCS is a valid and reliable tool for assessing concern about falling in people with SCI dependent on manual wheelchairs. The SCI-FCS could also assist in determining the effectiveness of fall minimization programs.

  14. The polyadenylation factor subunit CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30: A key factor of programmed cell death and a regulator of immunity in arabidopsis

    KAUST Repository

    Bruggeman, Quentin

    2014-04-04

    Programmed cell death (PCD) is essential for several aspects of plant life, including development and stress responses. Indeed, incompatible plant-pathogen interactions are well known to induce the hypersensitive response, a localized cell death. Mutational analyses have identified several key PCD components, and we recently identified the mips1 mutant of Arabidopsis (Arabidopsis thaliana), which is deficient for the key enzyme catalyzing the limiting step of myoinositol synthesis. One of the most striking features of mips1 is the light-dependent formation of lesions on leaves due to salicylic acid (SA)-dependent PCD, revealing roles for myoinositol or inositol derivatives in the regulation of PCD. Here, we identified a regulator of plant PCD by screening for mutants that display transcriptomic profiles opposing that of the mips1 mutant. Our screen identified the oxt6 mutant, which has been described previously as being tolerant to oxidative stress. In the oxt6 mutant, a transfer DNA is inserted in the CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30 (CPSF30) gene, which encodes a polyadenylation factor subunit homolog. We show that CPSF30 is required for lesion formation in mips1 via SA-dependent signaling, that the prodeath function of CPSF30 is not mediated by changes in the glutathione status, and that CPSF30 activity is required for Pseudomonas syringae resistance. We also show that the oxt6 mutation suppresses cell death in other lesion-mimic mutants, including lesion-simulating disease1, mitogen-activated protein kinase4, constitutive expressor of pathogenesis-related genes5, and catalase2, suggesting that CPSF30 and, thus, the control of messenger RNA 3′ end processing, through the regulation of SA production, is a key component of plant immune responses. © 2014 American Society of Plant Biologists. All rights reserved.

  15. Public concern about industrial hazards

    Energy Technology Data Exchange (ETDEWEB)

    Stallen, P.J.M.; Tomas, A.

    1988-06-01

    In this paper the authors propose adopting a noncognitive perspective for the understanding of people's anxiety or, its opposite, feelings of security about living near hazardous industrial facilities. Results of their empirical investigations among residents of a heavily industrialized area indicate that at least four qualitatively different response patterns exist: the Secure, the Accepting, the Defensive, and the Vigilant response. In this order manifest anxiety increases, which increase is shown to be a function of the assessment of the threat, of the opportunities for personal control (specific), and of hope (generalized) to bring about a better environment by one's own action. As an application of the usefulness of this typology they discuss the various explanations for the often-observed male/female difference in anxiety regarding industrial threat.

  16. Impact of a school-based disordered eating prevention program in adolescent girls: general and specific effects depending on adherence to the interactive activities.

    Science.gov (United States)

    López-Guimerà, Gemma; Sánchez-Carracedo, David; Fauquet, Jordi; Portell, Mariona; Raich, Rosa M

    2011-05-01

    This study assessed the impact of a school-based program aimed at preventing disordered eating. The program was based on the media-literacy approach and has interactive format. The program was assessed under strong methodological conditions. Seven schools with 263 Spanish adolescent girls in the area of Barcelona, were randomly assigned to either the complete prevention program condition, the partial program condition or the non-treatment control condition, and assessed at pre, post and 6-month follow-up. The program was effective in generating positive changes at follow-up. The effects sizes (ES(d) = 0.29 to ES(d) = 0.38) were greater, on average, than that obtained up to now in selective-universal programs, and similar or greater than that achieved by targeted prevention programs. The results indicate a greater and relevant effect size of the intervention in those participants who completed the inter-session interactive activities (ES(d) = 0.29 to ES(d) = 0.45) although the differences were not significant. These results suggest the importance of monitoring adherence to the activities in all programs defined as "interactive". The implications and limitations of this study are discussed.

  17. Bilateral childhood visual impairment: child and parent concerns.

    Science.gov (United States)

    Liebermann, Laura; Leske, David A; Hatt, Sarah R; Castañeda, Yolanda S; Wernimont, Suzanne M; Cheng-Patel, Christina S; Birch, Eileen E; Holmes, Jonathan M

    2017-06-01

    To identify specific health-related quality of life and visual function concerns affecting children with bilateral visual impairment as expressed by children or one of their parents (proxy) and concerns affecting the parents themselves. A total of 37 children visual impairment (visual acuity worse than 20/70 in the better eye) and one parent for each child were prospectively enrolled. Semistructured individual interviews were performed with children 5-15 years of age (n = 16) and with one parent for each child (ages 0-15 years, N = 37). Interview transcripts were analyzed using NVivo software. Categories of concern were identified from both child and parent interviews, from which broad themes were identified. The frequencies of the themes and specific categories of concerns were calculated. Regarding the child's experience, categories of concern were grouped into 6 themes: visual function (expressed by 13 of 16 children [81%] and 33 of 37 parents [89%]), treatment (63% and 54%), emotions (50% and 68%), social (50% and 70%), physical discomfort (50% and 22%), and worry (38% and 8%). Concerns expressed regarding the parents' own experience were grouped into 5 themes: worry (100%), compensate-adjust for condition (89%), treatment (84%), emotions (81%), and affects family (46%). Individual interviews identified a wide spectrum of concerns in children with visual impairment and their parents, affecting functional, emotional, social and physical domains. Specific concerns will be used to develop patient-derived questionnaires for quantifying the effects of visual impairment on children and parents in everyday life. Copyright © 2017 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.

  18. Occupational health concerns in the welding industry.

    Science.gov (United States)

    Korczynski, R E

    2000-12-01

    The Workplace Safety and Health Branch initiated a proactive study in the welding industry in Manitoba. Eight welding companies participated in this study. Health concerns raised by welders were welders' flash, sore/red/teary eyes, headaches, nosebleeds, and a black mucous discharge from their nasal membrane. Most welders expressed concern regarding excessive smoke levels in the workplace and inadequate ventilation. Types of welding identified were MIG mild steel, MIG stainless steel, and TIG aluminum. Monitoring involved an assessment of noise levels, fume composition, and carbon monoxide and ozone concentrations. Metal analyses were according to National Institute for Occupational Safety and Health (NIOSH) Method 7300. Noise dosimeters used were the Quest model 100 and Micro 14 & 15. Carbon monoxide was monitored using the Gastech Model 4700 and ozone using the AID Portable Ozone Meter Model 560. In Manitoba, a hearing conservation program is required when the equivalent sound exposure level (normalized Lex 8-hr) exceeds 80 dBA-weighted. The American Conference of Governmental Industrial Hygienists' threshold limit value-time weighted average (ACGIH TLV-TWA) for iron is 5.0 mg/m3, manganese is 0.2 mg/m3, carbon monoxide is 25 ppm, and ozone is 0.05 ppm (heavy work), 0.08 ppm (moderate work), and 0.1 ppm (light work). Welders' personal exposures to manganese ranged from 0.01-4.93 mg/m3 (N = 42; AM = 0.5; GM = 0.2; SD +/- 0.9; GSD +/- 3.2) and to iron ranged from 0.04-16.29 mg/m3 (N = 42; AM = 3.0; GM = 1.4; SD +/- 3.5; GSD +/- 2.5). Noise exposures ranged from 79-98 dBA (N = 44; AM = 88.9; GM = 88.8; SD +/- 4.2; GSD +/- 1.0). Carbon monoxide levels were less than 5.0 ppm (at source) and ozone levels varied from 0.4-0.6 ppm (at source). Ventilation upgrades in the workplace were required in most welding shops. Only 7 percent of the welders wore respiratory protection. A hearing conservation program and hearing protection were required at all monitored workplaces.

  19. Zika Virus Infection: Current Concerns and Perspectives.

    Science.gov (United States)

    Maharajan, Mari Kannan; Ranjan, Aruna; Chu, Jian Feng; Foo, Wei Lim; Chai, Zhi Xin; Lau, Eileen YinYien; Ye, Heuy Mien; Theam, Xi Jin; Lok, Yen Ling

    2016-12-01

    The Zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect Zika virus, as it is often recognized as a mild disease without being identified. Many Zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical presentation. The aim of this review was to provide a critical and comprehensive overview of the published peer-reviewed evidence related to clinical presentations, various diagnostic methods and modes of transmission of Zika virus infection, as well as potential therapeutic targets to combat microcephaly. Zika virus is mainly transmitted through bites from Aedes aegypti mosquito. It can also be transmitted through blood, perinatally and sexually. Pregnant women are advised to postpone or avoid travelling to areas where active Zika virus transmission is reported, as this infection is directly linked to foetal microcephaly. Due to the high prevalence of Guillain-Barre syndrome and microcephaly in the endemic area, it is vital to confirm the diagnosis of Zika virus. Zika virus infection had been declared as a public health emergency and of international concern by the World Health Organisation. Governments and agencies should play an important role in terms of investing time and resources to fundamentally understand this infection so that a vaccine can be developed besides raising awareness.

  20. Programa único o diferenciado: especificidad curricular de la escuela rural uruguaya - Common or differentiated school programs: uruguayan rural school curriculum specificity

    Directory of Open Access Journals (Sweden)

    Limber Elbio Santos, Uruguay

    2014-05-01

    Full Text Available O artigo se refere ao fenômeno da especificidade curricular que as escolas rurais uruguaias têm tido durante mais de um século e à ruptura histórica registrada em 2009 quando se começou a aplicar uma estrutura curricular comum a escolas urbanas e rurais. Analisam-se as circunstâncias históricas da pedagogia rural e, em particular, uma de suas materialidades simbolicamente mais potentes constituída pelo Programa para Escolas Rurais de 1949. Assim mesmo, refere-se ao peso que essa pedagogia continua tendo atualmente e da maneira como influi na gestão curricular do programa único. As especificidades social e didática da escola rural têm efeitos evidentes sobre o programa curricular no seu sentido mais amplo, com alcances muito mais extensos que os relativos ao currículo prescrito. No entanto, o desafio da escola rural atual de abordar a nova estrutura curricular de caráter único não é tão diferente do que se registrou historicamente: dialogar com o meio de igual para igual e maximizar o potencial de aprendizagem proporcionado pela instituição educacional, pela comunidade e estrutura multidisciplinar do grupo.Palavras-chave: escola rural, currículo, programa, pedagogia rural. COMMON OR DIFFERENTIATED SCHOOL PROGRAMS: URUGUAYAN RURAL SCHOOL CURRICULUM SPECIFICITY AbstractThe paper refers to the phenomenon of the Curriculum specificity to which the Rural Schools had for more than a century inUruguayand to the historic rupture registered in 2009 when a common Curriculum for Rural and Urban schools was introduced. The paper analyses the historic circumstances of the Rural Pedagogy and, in particular, one of its most potent symbolic materiality constituted of the 1949 program for Rural Education. The analysis show that the challenge to current Rural Education is not that different to that registered historically: to dialogue with the environment and take maximum advantage of the potential to learn which is provided by the

  1. Addressing concerns and achieving expectations

    Energy Technology Data Exchange (ETDEWEB)

    Miller, C.L. [Dept. of Energy, Washington, DC (United States)

    1995-12-01

    Approximately 2-1/2 years ago many of us were gathered here in Prague at a similar conference with a similar name, {open_quotes}Energy and Environment: Transitions in Eastern Europe.{close_quotes} Over 300 professionals from 26 nations attended. The objective of the conference was to: Facilitate the Solution of Long and Short Term Energy and Environmental Problems in Eastern Europe by Bringing Together People, ideas and technologies which could be applied to specific problems in a logical step-by-step manner. It was conceded at the time that the long term solution would consist of thoughtfully integrated steps and that the conference was the first step. We are here in the Czech Republic again this week to continue what was started. As before, this conference continues to: (1) Provide a forum to identify and discuss cost-effective environmentally acceptable energy and environmental technology options and their associated socioeconomic issues. (2) Stimulate the Formation of business partnerships (3) Identify key barrier issues hindering technology applications and identify implementation pathways that eliminate or avoid obstacles to progress.

  2. The U.S. commercial air tour industry: a review of aviation safety concerns.

    Science.gov (United States)

    Ballard, Sarah-Blythe

    2014-02-01

    The U.S. Title 14 Code of Federal Regulations defines commercial air tours as "flight[s] conducted for compensation or hire in an airplane or helicopter where a purpose of the flight is sightseeing." The incidence of air tour crashes in the United States is disproportionately high relative to similar commercial aviation operations, and air tours operating under Part 91 governance crash significantly more than those governed by Part 135. This paper reviews the government and industry response to four specific areas of air tour safety concern: surveillance of flight operations, pilot factors, regulatory standardization, and maintenance quality assurance. It concludes that the government and industry have successfully addressed many of these tenet issues, most notably by: advancing the operations surveillance infrastructure through implementation of en route, ground-based, and technological surveillance methods; developing Aeronautical Decision Making and cue-based training programs for air tour pilots; consolidating federal air tour regulations under Part 136; and developing public-private partnerships for raising maintenance operating standards and improving quality assurance programs. However, opportunities remain to improve air tour safety by: increasing the number and efficiency of flight surveillance programs; addressing pilot fatigue with more restrictive flight hour limitations for air tour pilots; ensuring widespread uptake of maintenance quality assurance programs, especially among high-risk operators not currently affiliated with private air tour safety programs; and eliminating the 25-mile exception allowing Part 91 operators to conduct commercial air tours without the safety oversight required of Part 135 operators.

  3. Mental Health Concerns: Veterans & Active Duty

    Science.gov (United States)

    ... dialing 1-800-273-8255 and pressing 1. Mental Health Concerns There are three primary mental health concerns ... care or call 911. How Will Asking for Mental Health Treatment Affect My Career? Military personnel have always ...

  4. Concerns and Discomforts of Pregnancy - Varicose Veins

    Science.gov (United States)

    Concerns and Discomforts of Pregnancy - Varicose Veins Varicose veins are enlarged veins you may see on your legs. They can itch, ... Healthy Roads Media project www. healthyroadsmedia. org English - Concerns and Discomforts of Pregnancy (Varicose Veins) Last reviewed 2012

  5. Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

    Directory of Open Access Journals (Sweden)

    Robert J. Berry

    2011-03-01

    Full Text Available Periconceptional intake of folic acid is known to reduce a woman’s risk of having an infant affected by a neural tube birth defect (NTD. National programs to mandate fortification of food with folic acid have reduced the prevalence of NTDs worldwide. Uncertainty surrounding possible unintended consequences has led to concerns about higher folic acid intake and food fortification programs. This uncertainty emphasizes the need to continually monitor fortification programs for accurate measures of their effect and the ability to address concerns as they arise. This review highlights the history, effect, concerns, and future directions of folic acid food fortification programs.

  6. Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

    Science.gov (United States)

    Crider, Krista S.; Bailey, Lynn B.; Berry, Robert J.

    2011-01-01

    Periconceptional intake of folic acid is known to reduce a woman’s risk of having an infant affected by a neural tube birth defect (NTD). National programs to mandate fortification of food with folic acid have reduced the prevalence of NTDs worldwide. Uncertainty surrounding possible unintended consequences has led to concerns about higher folic acid intake and food fortification programs. This uncertainty emphasizes the need to continually monitor fortification programs for accurate measures of their effect and the ability to address concerns as they arise. This review highlights the history, effect, concerns, and future directions of folic acid food fortification programs. PMID:22254102

  7. Crosscutting concerns in J2EE applications

    NARCIS (Netherlands)

    A. Mesbah (Ali); A. van Deursen (Arie)

    2005-01-01

    textabstractWe explore the evolution benefits of adopting aspects in a J2EE setting by studying crosscutting concerns in a typical J2EE application. To identify these concerns, we take a top-down as well as a bottom-up approach. In the top-down view we focus on typical concerns that are known to be

  8. Crosscutting concerns in J2EE applications

    NARCIS (Netherlands)

    A. Mesbah (Ali); A. van Deursen (Arie)

    2005-01-01

    htmlabstract We explore the evolution benefits of adopting aspects in a J2EE setting by studying crosscutting concerns in a typical J2EE application. To identify these concerns, we take a top-down as well as a bottom-up approach. In the topdown view we focus on typical concerns that are known to be

  9. Writing Centre Tutoring Sessions: Addressing Students' Concerns

    Science.gov (United States)

    Winder, Roger; Kathpalia, Sujata S.; Koo, Swit Ling

    2016-01-01

    The guiding principle behind university writing centres is to focus on the process of writing rather than the finished product, prioritising higher order concerns related to organisation and argumentation of texts rather than lower order concerns of grammar and punctuation. Using survey-based data, this paper examines students' concerns regarding…

  10. The Sensitivity and Specificity of Using a Computer Aided Diagnosis Program for Automatically Scoring Chest X-Rays of Presumptive TB Patients Compared with Xpert MTB/RIF in Lusaka Zambia

    NARCIS (Netherlands)

    Muyoyeta, M.; Maduskar, P.; Moyo, M.; Kasese, N.; Milimo, D.; Spooner, R.; Kapata, N.; Hogeweg, L.; Ginneken, B. van; Ayles, H.

    2014-01-01

    To determine the sensitivity and specificity of a Computer Aided Diagnosis (CAD) program for scoring chest x-rays (CXRs) of presumptive tuberculosis (TB) patients compared to Xpert MTB/RIF (Xpert).Consecutive presumptive TB patients with a cough of any duration were offered digital CXR, and opt out

  11. Concerns and coping styles in adolescents from Lima

    Directory of Open Access Journals (Sweden)

    Patricia Martínez Uribe

    2001-12-01

    Full Text Available Combining qualitative and quantitative methodology, the study describes the main concerns of a group of adolescents and the strategies they use to cope with such concerns according to socio-demographic variables (age, sex and type of school. It is a descriptive study, with a transsectional design, of 413 adolescents from 13 to 18 years. The used instrument was the specific form of the Adolescent Coping Scale (ACS (Frydenberg & Lewis, 1997 that included oneopen question regarding their main concern. It was found that their major concerns are centeredin their future and school performance and that the most used coping strategies were Concernand Work Hard. It was found that socio-demographic variables make important differences among the different groups.

  12. Near Term Hybrid Passenger Vehicle Development Program. Phase I, Final report. Appendix A: mission analysis and performance specification studies. Volume II. Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Traversi, M.; Barbarek, L.A.C.

    1979-05-18

    These appendices to the mission analysis report for the Near Term Hybrid Vehicle program contain data on passenger vehicle usage by purpose, trip length, travel speed, vehicle age, vehicle ownership and fuel economy, and US demographics. (LCL)

  13. Big Opportunities and Big Concerns of Big Data in Education

    Science.gov (United States)

    Wang, Yinying

    2016-01-01

    Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

  14. Concepts Concerning 'Disease\\' Causation, Control, and the current ...

    African Journals Online (AJOL)

    There is an ethical necessity that doctors understand the complex social, political, environmental and economic dynamics involved in infectious disease outbreaks. This article discusses some important concepts concerning 'disease' causation and control with specific reference to the current cholera outbreak in Zimbabwe ...

  15. Occurrence of Medical Concerns in Psychiatric Outpatients with Intellectual Disabilities

    Science.gov (United States)

    Azimi, Kousha; Modi, Miti; Hurlbut, Janice; Lunsky, Yona

    2016-01-01

    Despite the fact that adults with both intellectual disabilities (ID) and psychiatric disorders are at increased risk for physical health problems, few studies have described their medical concerns specifically. This study reports on the rates of physical health issues and completion of recommended health screenings among 78 adult outpatients with…

  16. Specific Phobias

    Science.gov (United States)

    ... Health This information in Spanish ( en español ) Specific phobias Treatment More information on specific phobias A specific ... psychotherapy. Return to top More information on Specific phobias Explore other publications and websites Phobias (Copyright © Mayo ...

  17. Evaluation of pharmaceutical concerns in Germany: frequency and potential reasons.

    Science.gov (United States)

    Gradl, Gabriele; Krieg, Eva-Maria; Schulz, Martin

    2016-01-01

    Generic substitution can have unintended consequences. In Germany, brand name to generic or generic to generic switching is mainly driven by rebate contracts. Frequent switching may raise concerns about bio- and therapeutic equivalence. Expected patient confusion may result in compromised medication adherence or new onset of other drug-related problems. Since 2008, pharmacists are allowed to deviate from rebate contracts by denying substitution due to pharmaceutical concerns on an individual basis. To explore the frequency of documented pharmaceutical concerns in Germany between July 2011 and December 2013 and to identify the medicines most frequently related to pharmaceutical concerns in 2013. We analyzed documented pharmaceutical concerns in all prescribed drugs at the expense of any statutory health insurance company requiring pharmacies' generic substitution according to rebate contracts. Since July 2011, the frequency of documented pharmaceutical concerns in relation to prescribed drug products with rebate contracts requiring substitution increased consistently and doubled between July 2011 and July 2013. Overall in 2013, the trend of the two previous years continued and reached approximately 1.5%. The most affected drugs/drug classes were thyroid hormones (in particular combinations with iodide; 15.9%) followed by ondansetron (12.5%), and levothyroxine (11.3%). For all drugs/drug classes under investigation, product-, patient- or disease-related aspects could be identified which are potential reasons to deny substitution and to document pharmaceutical concerns. Although there is no electronic recording of the specific reasons for pharmaceutical concerns in claims data, our analyses support the assumption that pharmacists make use of this instrument based on individual clinical decisions and as required by contract. Pharmaceutical concerns are, therefore, an important instrument for pharmacies to refuse generic substitution. They are considered to prevent

  18. Evaluation of pharmaceutical concerns in Germany: frequency and potential reasons

    Directory of Open Access Journals (Sweden)

    Gradl G

    2016-09-01

    Full Text Available Background: Generic substitution can have unintended consequences. In Germany, brand name to generic or generic to generic switching is mainly driven by rebate contracts. Frequent switching may raise concerns about bio- and therapeutic equivalence. Expected patient confusion may result in compromised medication adherence or new onset of other drug-related problems. Since 2008, pharmacists are allowed to deviate from rebate contracts by denying substitution due to pharmaceutical concerns on an individual basis. Objectives: To explore the frequency of documented pharmaceutical concerns in Germany between July 2011 and December 2013 and to identify the medicines most frequently related to pharmaceutical concerns in 2013. Methods: We analyzed documented pharmaceutical concerns in all prescribed drugs at the expense of any statutory health insurance company requiring pharmacies’ generic substitution according to rebate contracts. Results: Since July 2011, the frequency of documented pharmaceutical concerns in relation to prescribed drug products with rebate contracts requiring substitution increased consistently and doubled between July 2011 and July 2013. Overall in 2013, the trend of the two previous years continued and reached approximately 1.5%. The most affected drugs/drug classes were thyroid hormones (in particular combinations with iodide; 15.9% followed by ondansetron (12.5%, and levothyroxine (11.3%. For all drugs/drug classes under investigation, product-, patient- or disease-related aspects could be identified which are potential reasons to deny substitution and to document pharmaceutical concerns. Conclusions: Although there is no electronic recording of the specific reasons for pharmaceutical concerns in claims data, our analyses support the assumption that pharmacists make use of this instrument based on individual clinical decisions and as required by contract. Pharmaceutical concerns are, therefore, an important instrument for

  19. Assessment of the Motivational Reactions of Teachers to a School-Based Performance Award Program.

    Science.gov (United States)

    Heneman, Herbert G., III

    1998-01-01

    Assessed teachers' motivational reactions to an award program in the Charlotte-Mecklenburg (North Carolina) schools and compared findings with those from a similar program in Kentucky. The goals were specific, understandable, focused and challenging, but teachers had concerns about meeting higher future goals. Monetary bonuses were less motivating…

  20. Community and species-specific responses of wild bees to insect pest control programs applied to a pollinator-dependent crop.

    Science.gov (United States)

    Tuell, Julianna K; Isaacs, Rufus

    2010-06-01

    Wild bee conservation is regarded as essential for sustainable production of pollinator-dependent crops, yet little is known about the effects on wild bee communities of typical insect pest management programs used postbloom. We developed an insecticide program risk (IPR) index to quantify the relative risk to wild bees of insecticide programs applied to blueberry fields. This was used to determine the relationship between IPR and the abundance, diversity, and richness of wild bee communities sampled during three successive flowering seasons. In 2 of 3 yr, bee abundance and species richness declined with increasing IPR. Bee diversity declined with IPR in one of 3 yr. These results indicate that wild bee communities are negatively affected by increasingly intensive chemical pest management activities in crop fields and that interyear variability in bee populations has the potential to mask such effects in short-term studies. When several wild bee species were analyzed separately, two of three solitary and one of three social blueberry-foraging species declined with increasing IPR values, suggesting that different life histories and nesting habits may help some bee populations escape the negative effects of insecticides applied after bloom. Pollinator conservation programs aimed strictly at reducing insecticide use may have varying success, depending on the biology of the target bee species. The IPR index provides a standard method to compare pest management programs for their potential effect on wild bee communities, with broad application for use in other agricultural systems.

  1. An online virtual-patient program to teach pharmacists and pharmacy students how to provide diabetes-specific medication therapy management.

    Science.gov (United States)

    Battaglia, Jessica N; Kieser, Mara A; Bruskiewitz, Ruth H; Pitterle, Michael E; Thorpe, Joshua M

    2012-09-10

    To develop, implement, and assess the effectiveness of an online medication therapy management (MTM) program to train pharmacists and pharmacy students in providing MTM services for patients with diabetes and to increase their intent to perform these services. An online program was created using an Internet-based learning platform to simulate 4 MTM meetings between a pharmacist and a virtual patient diagnosed with diabetes. Eighty students and 42 pharmacists completed the program. After completing the program, scores on post-intervention assessments showed significant improvement in 2 areas: control over performing MTM, and knowledge of how to perform MTM. Students had a significantly less-positive attitude about MTM and a decline in their perception of the social expectation that MTM is part of the practice of pharmacy, while pharmacists' attitudes did not change significantly in these areas. This online program using a virtual patient improved both participants' belief that they have control over performing MTM, and their knowledge of how to perform MTM for diabetic patients, which may increase the likelihood that pharmacists and pharmacy students will perform MTM in the future.

  2. Transient T wave Changes Concerning Arrhythmia

    Directory of Open Access Journals (Sweden)

    Hirofumi Tasaki, MD PhD

    2007-01-01

    Full Text Available T-wave changes are thought to be associated with the repolarization phase of myocardial action potential. Although it has been known that persistent T-wave change is associated with the heart disease or the prognosis, the sensitivity and the specificity are not necessarily satisfactory for clinical therapeutic strategy. Recent basic studies have shown that, in some kinds of pathological states, transient repolarization changes of myocardial action potential were associated with life-threatening arrhythmia. Also clinical studies are being conducted to elucidate the clinical implication of transient T-wave changes on electrocardiography (ECG in such an arrhythmia. Transient repolarization or T-wave change is thought to occur because of environmental or neurohumoral factors, circadian variation, stretching of myocardium or other triggers in daily life, resulting in fatal arrhythmia. Such fatal arrhythmias are thought to occur under restricted conditions even in the patients with serious heart disease. It is important to clarify and utilize the transient T-wave change directly associated with the fatal arrhythmia on a clinical basis. In this article, we first assess the mechanisms of transient repolarization or T-wave changes on ECG concerning fatal arrhythmia, and afterwards refer to possible attempts at clinical evaluation and application.

  3. Benchmarketing - Fashionable Term Concerning Traditional Processes

    Directory of Open Access Journals (Sweden)

    Mircea Udrescu

    2016-06-01

    Full Text Available Marketing is a major factor to boost the competitiveness of the firm in an environment which is more and more turbulent. It centers the company’s management as being the ideal satisfaction of the current and potential consumer. This is why, in our conception, the marketing’s management represents a subsystem of the company’s’ general management by which shall be administered to specific activities, and also designed to contour the company’s’ activity object. In this article, the intent is to highlight the fact that the benchmarketing has come loose from cultivating the traditional process to the innovative organizational culture product. In this paper, the authors consider benchmarketing as a process of qualitative organizational culture adaptation to market requirements, depending on the context, so as to ensure the improvement of the economic criteria of appreciation of the business lucrative activities. Based on direct observations concerning small firms, followed by analysis, comparison and synthesis, the authors suggest taking into consideration the theoretical and practical benchmarketings’ approach, as being the current strategy of acquiring and cultivating excellence, as initiation philosophy and business development.

  4. The role of parental alcohol-specific communication in early adolescents’ alcohol use

    NARCIS (Netherlands)

    Vorst, H. van der; Burk, W.J.; Engels, R.C.M.E.

    2010-01-01

    Many alcohol prevention programs advocate conversations about alcohol between parents and children because verbal communication is the most direct way for parents to express their thoughts, rules, and concerns about alcohol to their children, so called alcohol-specific communication. Nevertheless,

  5. Implementing Specification Freedoms.

    Science.gov (United States)

    1983-04-01

    Sheila Coyazo for editing the final draft. Portions of this report appeared in a paper of the same name published in Science of Computer Programming [21...University of Edinburgh, Technical Report DAI 54, 1978. 21. Feather, M. S., and P. E. London, "Implementing specification freedoms," Science of Computer Programming 2

  6. Predictors of Stature Concerns among Young Chinese Women and Men

    Directory of Open Access Journals (Sweden)

    Qingqing Sun

    2017-07-01

    Full Text Available Stature concerns are a prominent source of body dissatisfaction for Chinese teenagers and young adults, yet little is known about the psychological factors that account for it. Therefore, this study examined social cultural model and objectification theory as explanations for stature concerns in a sample of undergraduate men and women from a university in Henan, China. Given height is a salient physical attribute for Chinese adolescents and young adults, we extended past studies on objectification theory by adding separate measures for stature surveillance. Participants (231 men, 473 women completed a questionnaire assaying measures of sociocultural model features (appearance pressure from mass media and close interpersonal networks, appearance social comparisons, objectified body consciousness (body surveillance, body shame, stature surveillance, and stature concerns. In multiple regression models for each gender, appearance pressure from the mass media and stature surveillance were robust predictors of stature concerns for both genders, independent of reported height. Body surveillance predicted stature concerns for women but not men. These findings contribute to the broader field of multicultural body image research and may help to account for specific culturally salient appearance concerns within samples of young Chinese women and men.

  7. Summary proceedings of a workshop on Bioremediation and its Societal Implications and Concerns (BASIC)

    Energy Technology Data Exchange (ETDEWEB)

    Drell, D.W. [Department of Energy, Germantown, MD (United States). Office of Health and Environmental Research, Health Effects and Life Sciences Research Division; Metting, F.B. Jr. [Pacific Northwest National Lab., Richland, WA (United States); Wuy, L.D. [ed.] [Lawrence Berkeley National Lab., CA (United States)

    1996-11-01

    This document summarizes the proceedings of a workshop on Bioremediation and Its Societal Implications and Concerns (BASIC) held July 18-19, 1996 at the Airlie Center near Warrenton, Virginia. The workshop was sponsored by the Office of Health and Environmental Research (OHER), U.S. Department of Energy (DOE), as part of its fundamental research program in Natural and Accelerated Bioremediation Research (NABIR). The information summarized in these proceedings represents the general conclusions of the workshop participants, and not the opinions of workshop organizers or sponsors. Neither are they consensus opinions, as opinions differed among participants on a number of points. The general conclusions presented below were reached through a review, synthesis, and condensation of notes taken by NABIR Program Office staff and OHER program managers throughout the workshop. Specific contributions by participants during breakout sessions are recorded in bullet form in the appropriate sections, without attribution to the contributors. These contributions were transcribed as faithfully as possible from notes about the original discussions. They were edited only to make them grammatically correct, parallel in structure, and understandable to someone not familiar with the NABIR Program or BASIC element.

  8. 27 CFR 13.101 - Appeals concerning use of the term “organic.”

    Science.gov (United States)

    2010-04-01

    ... Agencies' Rules § 13.101 Appeals concerning use of the term “organic.” To appeal a determination that an organic claim on a label does not comply with the National Organic Program rules in 7 CFR part 205, contact the Program Manager, National Organic Program (NOP), Agricultural Marketing Service, United States...

  9. Concerns of anophthalmic patients wearing artificial eyes.

    Science.gov (United States)

    Pine, Keith; Sloan, Brian; Stewart, Joanna; Jacobs, Robert J

    2011-01-01

    To identify the concerns of experienced artificial eye wearers and investigate whether these had changed since they lost their eye. A retrospective study of private practice patients. Sixty-three experienced artificial eye wearers. An anonymous questionnaire was posted to participants. Paired Wilcoxon tests were used to investigate changes to concern levels over time. Ordinal logistic regression was used to investigate associations of demographic variables with concern levels. Changes in level of concern over time. At the time of initial eye loss, participants were mainly concerned about the health of their remaining eye, coping with monocularity and receiving good advice. Between initial eye loss and the present, reductions in concern occurred with judging distance, peripheral vision, appearance, receiving good advice, comfort, retention, colour and movement of the artificial eye, fullness of orbit, loss of balance and postoperative pain. Patients whose jobs involved the public were more concerned about appearance and reduced visual range than those in other occupations. Participants' chief present-day concerns were health of the remaining eye and watering, crusting and discharge. All results above had a probability vision and appearance all decrease over time may help clinicians in counselling these patients. Watering, crusting and discharge was the chief present-day concern after health of the remaining eye. © 2010 The Authors. Clinical and Experimental Ophthalmology © 2010 Royal Australian and New Zealand College of Ophthalmologists.

  10. A Learning Curriculum: Toward Student-Driven Pedagogy in the Context of Adult English for Academic Purposes, English for Specific Purposes, and Workplace English Programs

    Science.gov (United States)

    Ananyeva, Maria

    2014-01-01

    This article introduces the concept of a learning curriculum that places adult English as a second language (ESL) students' needs in the center and encourages the engagement of ESL learners in curriculum design. The study is based on contemporary research in the field of adult ESL program planning. It summarizes key components of a learning…

  11. Are All Program Elements Created Equal? Relations Between Specific Social and Emotional Learning Components and Teacher-Student Classroom Interaction Quality.

    Science.gov (United States)

    Abry, Tashia; Rimm-Kaufman, Sara E; Curby, Timothy W

    2017-02-01

    School-based social and emotional learning (SEL) programs are presented to educators with little understanding of the program components that have the greatest leverage for improving targeted outcomes. Conducted in the context of a randomized controlled trial, the present study used variation in treatment teachers' (N = 143) implementation of four core components of the Responsive Classroom approach to examine relations between each component and the quality of teachers' emotional, organizational, and instructional interactions in third, fourth, and fifth grade classrooms (controlling for pre-intervention interaction quality and other covariates). We also examined the extent to which these relations varied as a function of teachers' baseline levels of interaction quality. Indices of teachers' implementation of Morning Meeting, Rule Creation, Interactive Modeling, and Academic Choice were derived from a combination of teacher-reported surveys and classroom observations. Ratings of teacher-student classroom interactions were aggregated across five observations conducted throughout the school year. Structural path models indicated that teachers' use of Morning Meeting and Academic Choice related to higher levels of emotionally supportive interactions; Academic Choice also related to higher levels of instructional interactions. In addition, teachers' baseline interaction quality moderated several associations such that the strongest relations between RC component use and interaction quality emerged for teachers with the lowest baseline interaction quality. Results highlight the value of examining individual program components toward the identification of program active ingredients that can inform intervention optimization and teacher professional development.

  12. Food colors: Existing and emerging food safety concerns.

    Science.gov (United States)

    Oplatowska-Stachowiak, Michalina; Elliott, Christopher T

    2017-02-11

    Food colors are added to different types of commodities to increase their visual attractiveness or to compensate for natural color variations. The use of these additives is strictly regulated in the European Union, the United States, and many other countries worldwide. There is a growing concern about the safety of some commonly used legal food colorants and there is a trend to replace the synthetic forms with natural products. Additionally, a number of dyes with known or suspected genotoxic or carcinogenic properties have been shown to be added illegally to foods. Robust monitoring programs based on reliable detection methods are required to assure the food is free from harmful colors. The aim of this review is to present an up to date status of the various concerns arising from use of color additives in food. The most important food safety concerns in the field of food colors are lack of uniform regulation concerning legal food colors worldwide, possible link of artificial colors to hyperactive behavior, replacement of synthetic colors with natural ones, and the presence of harmful illegal dyes-both known but also new, emerging ones in food. The legal status of food color additives in the EU, United States, and worldwide is summarized. The reported negative health effects of both legal and illegal colors are presented. The European Rapid Alert System for Food and Feed notifications and US import alerts concerning food colors are analyzed and trends in fraudulent use of color additives identified. The detection methods for synthetic colors are also reviewed.

  13. Teacher Concerns Pertaining to Response to Intervention

    Science.gov (United States)

    Thompson, Leah J.; Fearrington, Jamie Yarbrough

    2013-01-01

    This article examines teacher concerns during the implementation of response to intervention at a small, rural elementary school. The Stages of Concern Questionnaire (George, Hall, & Stiegelbauer, 2008) was administered three times over the course of the academic year to 46 teachers and school staff. The hypothesis was that teacher concerns…

  14. Isolated thoughts and feelings and unsolved concerns

    DEFF Research Database (Denmark)

    Carstensøe-Seidenfaden, Pernille; Teilmann, Grete Katrine; Kensing, Finn

    2017-01-01

    , (2) striving for normality, (3) striving for independence and (4) worrying about future. Although adolescents and parents had same concerns and challenges living with type 1 diabetes, they were experienced differently. Their thoughts and feelings mostly remained isolated and their concerns...

  15. Addressing Teachers' Concerns about Teaching Evolution

    Science.gov (United States)

    Sanders, Martie; Ngxola, Nonyameko

    2009-01-01

    Evolution was introduced into the senior secondary school Life Sciences curriculum in South Africa for the first time in 2008. Research in other countries shows that evolution is an extremely controversial topic to teach, raising serious concerns for teachers. Curriculum change theory dealing with "stages of concern" suggests that…

  16. A review of IPv 6 security concerns

    CSIR Research Space (South Africa)

    Van Heerden, RP

    2012-08-01

    Full Text Available This study focuses on the security concerns of IPv 6. We make a broad introduction to IPv 6 then briefly look at the differences between the IPv 6 and IPv4 protocols, their known vulnerabilities and identify some security concerns when implementing IPv...

  17. Health Concern and Challenges Among School Adolescents

    African Journals Online (AJOL)

    Health Concern and Challenges Among School Adolescents Abebe G. et al 37. ORIGINAL „4 RTJ CLE. Health Concern and ... of adolescents behavioral, social and physical health problems should be given high priority; establishment of special ..... approach dealing with the full range of their health problems (7, 8, 21).

  18. Concerns about the implantable cardioverter defibrillator

    DEFF Research Database (Denmark)

    Pedersen, Susanne S.; van Domburg, Ron T; Theuns, Dominic A M J

    2005-01-01

    Patients with an implantable cardioverter defibrillator (ICD) are at increased risk of anxiety disorders. In turn, anxiety has been identified as a precipitant of ventricular arrhythmias. Anxiety may in part be attributed to concerns about the ICD firing, but the relationship between ICD concerns...

  19. Relation between humor and empathic concern.

    Science.gov (United States)

    Hampes, W P

    2001-02-01

    A series of studies have shown that humor is associated with close interpersonal relationships and effective in reducing stress, which in turn enhances empathy. Therefore, it was hypothesized that humor and empathic concern would be positively correlated. The Empathic Concern subscale of the Empathy Questionnaire, the Coping Humor Scale, the Multidimensional Sense of Humor Scale, and the Situational Humor Response Questionnaire were given to 124 subjects. Scores on the Empathic Concern subscale were significantly correlated with those on each of the humor scales. Types of humor may be an important variable in the relationship between empathic concern and humor. Both humor and empathic concern are associated for people with emotional intelligence who use these to interact effectively with other individuals. As such, it was suggested that exploration would yield a relation between humor and emotional self-awareness, which is also associated with emotional intelligence.

  20. Oak Ridge Reservation Federal Facility Agreement: Quarterly report for the Environmental Restoration Program. Volume 2, January--March 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    This report provides information about ER Program activities conducted on the Oak Ridge Reservation under the Federal Facility Agreement (FFA). Specifically, it includes information on milestones scheduled for completion during the reporting period as well as scheduled for completion during the next reporting period (quarter), accomplishments of the ER Program, concerns related to program work, and scheduled activities for the next quarter. It also provides a listing of the identity and assigned tasks of contractors performing ER Program work under the FFA.

  1. Low Levels of Empathic Concern Predict Utilitarian Moral Judgment

    Science.gov (United States)

    Gleichgerrcht, Ezequiel; Young, Liane

    2013-01-01

    Is it permissible to harm one to save many? Classic moral dilemmas are often defined by the conflict between a putatively rational response to maximize aggregate welfare (i.e., the utilitarian judgment) and an emotional aversion to harm (i.e., the non-utilitarian judgment). Here, we address two questions. First, what specific aspect of emotional responding is relevant for these judgments? Second, is this aspect of emotional responding selectively reduced in utilitarians or enhanced in non-utilitarians? The results reveal a key relationship between moral judgment and empathic concern in particular (i.e., feelings of warmth and compassion in response to someone in distress). Utilitarian participants showed significantly reduced empathic concern on an independent empathy measure. These findings therefore reveal diminished empathic concern in utilitarian moral judges. PMID:23593213

  2. Caregiver anxiety due to interstage feeding concerns.

    Science.gov (United States)

    Stewart, Jamie; Dempster, Robert; Allen, Robin; Miller-Tate, Holly; Dickson, Gabrielle; Fichtner, Samantha; Principe, Alex J; Fonseca, Rachel; Nicholson, Lisa; Cua, Clifford L

    2015-01-01

    Improved weight gain during the interstage (IS) period has been shown to improve overall outcomes in patients with single ventricle physiology (SVP). This emphasis on nutrition may have untoward effects, such as increasing anxiety/stress levels in caregivers, who are already known to be at risk for increased anxiety/stress levels. The goal of this study was to evaluate anxiety/stress levels of caregivers as it pertains to feeding during the IS period and to determine if certain characteristics were associated with higher anxiety/stress scores. Caregivers of children with SVP who completed the IS period, defined as the time between the first and second cardiac surgeries, were recruited. Baseline demographics were obtained. Anxiety/stress levels were measured via eight questions using a 0- to 10-point scale. Correlations were performed between demographic variables and anxiety/stress level scores. Fifty-six surveys were completed (39 males, 27 females) on 43 children. Fourteen children required tube feeds during the IS period. There were significant correlations between anxiety/stress scores and caregiver's gender, caregiver's age, caregiver's level of education, percent of time a caregiver spent feeding the child, if caregivers were taking medications for anxiety, and if the child was seen in the emergency room during the IS period. There were no correlation of anxiety/stress scores with caregiver's race, child's underlying cardiac diagnosis, age of child, route of feeding during the IS period, birth order of the child or number of children in the family, relationship status, or distance from the hospital. In general, caregivers of children with SVP experience anxiety/stress during the IS period specifically due to feeding concerns. Certain intrinsic and extrinsic characteristics were associated with higher anxiety/stress levels. Future studies are needed to determine how to minimize anxiety/stress levels during this stressful time period. © 2015 Wiley Periodicals

  3. Course and prognosis of recovery for chronic non-specific low back pain: Design, therapy program and baseline data of a prospective cohort study

    NARCIS (Netherlands)

    K. Verkerk (Karin); P.A.J. Luijsterburg (Pim); I. Ronchetti (Inge); H.S. Miedema (Harald); A.L. Pool-Goudzwaard (Annelies); J.-P. van Wingerden; B.W. Koes (Bart)

    2011-01-01

    textabstractBackground: There has been increasing focus on factors predicting the development of chronic musculoskeletal disorders. For patients already experiencing chronic non-specific low back pain it is also relevant to investigate which prognostic factors predict recovery. We present the design

  4. Are empathy and concern psychologically distinct?

    Science.gov (United States)

    Jordan, Matthew R; Amir, Dorsa; Bloom, Paul

    2016-12-01

    Researchers have long been interested in the relationship between feeling what you believe others feel-often described as empathy-and caring about the welfare of others-often described as compassion or concern. Many propose that empathy is a prerequisite for concern and is therefore the ultimate motivator of prosocial actions. To assess this hypothesis, the authors developed the Empathy Index, which consists of 2 novel scales, and explored their relationship to a measure of concern as well as to measures of cooperative and altruistic behavior. A series of factor analyses reveal that empathy and concern consistently load on different factors. Furthermore, they show that empathy and concern motivate different behaviors: concern for others is a uniquely positive predictor of prosocial action whereas empathy is either not predictive or negatively predictive of prosocial actions. Together these studies suggest that empathy and concern are psychologically distinct and empathy plays a more limited role in our moral lives than many believe. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  5. Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model.

    Science.gov (United States)

    Muralimanoharan, Sribalasubashini; Gao, Xiaoli; Weintraub, Susan; Myatt, Leslie; Maloyan, Alina

    2016-05-03

    The incidence of maternal obesity and its co-morbidities (diabetes, cardiovascular disease) continues to increase at an alarming rate, with major public health implications. In utero exposure to maternal obesity has been associated with development of cardiovascular and metabolic diseases in the offspring as a result of developmental programming. The placenta regulates maternal-fetal metabolism and shows significant changes in its function with maternal obesity. Autophagy is a cell-survival process, which is responsible for the degradation of damaged organelles and misfolded proteins. Here we show an activation of autophagosomal formation and autophagosome-lysosome fusion in placentas of males but not females from overweight (OW) and obese (OB) women vs. normal weight (NW) women. However, total autophagic activity in these placentas appeared to be decreased as it showed an increase in SQSTM1/p62 and a decrease in lysosomal biogenesis. A mouse model with a targeted deletion of the essential autophagy gene Atg7 in placental tissue showed significant placental abnormalities comparable to those seen in human placenta with maternal obesity. These included a decrease in expression of mitochondrial genes and antioxidants, and decreased lysosomal biogenesis. Strikingly, the knockout mice were developmentally programmed as they showed an increased sensitivity to high-fat diet-induced obesity, hyperglycemia, hyperinsulinemia, increased adiposity, and cardiac remodeling. In summary, our results indicate a sexual dimorphism in placental autophagy in response to maternal obesity. We also show that autophagy plays an important role in placental function and that inhibition of placental autophagy programs the offspring to obesity, and to metabolic and cardiovascular diseases.

  6. Recent developments concerning the fusion; Developpements recents sur la fusion

    Energy Technology Data Exchange (ETDEWEB)

    Jacquinot, J. [CEA/Cadarache, Dept. de Recherches sur la Fusion Controlee, DRFC, 13 - Saint Paul lez Durance (France); Andre, M. [CEA/DAM Ile de France, 91 - Bruyeres Le Chatel (France); Aymar, R. [ITER Joint Central Team Garching, Muenchen (Germany)] [and others

    2000-09-04

    Organized the 9 march 2000 by the SFEN, this meeting on the european program concerning the fusion, showed the utility of the exploitation and the enhancement of the actual technology (JET, Tore Supra, ASDEX) and the importance of the Europe engagement in the ITER program. The physical stakes for the magnetic fusion have been developed with a presentation of the progresses in the knowledge of the stability limits. A paper on the inertial fusion was based on the LMJ (Laser MegaJoule) project. The two blanket concepts chosen in the scope of the european program on the tritium blankets, have been discussed. These concepts will be validated by irradiation tests in the ITER-FEAT and adapted for a future reactor. (A.L.B.)

  7. Weight concerns, mood, and postpartum smoking relapse.

    Science.gov (United States)

    Levine, Michele D; Marcus, Marsha D; Kalarchian, Melissa A; Houck, Patricia R; Cheng, Yu

    2010-10-01

    The majority of women who quit smoking as a result of pregnancy will resume smoking during the first 6 months postpartum. Evidence suggests that changes in depressive symptoms, perceived stress, and concerns about weight may relate to postpartum smoking relapse. This study was designed to prospectively evaluate the relationship of mood and weight concerns to postpartum smoking among women who quit smoking during pregnancy. Pregnant women who had quit smoking (N=183) were recruited between February 2003 and November 2006. Women completed assessments of mood (depressive symptoms, perceived stress, positive and negative affect) and weight concerns during the third trimester of pregnancy and at 6, 12, and 24 weeks postpartum. Self-reported smoking status was verified by expired-air carbon monoxide and salivary cotinine at each assessment. Cox regression analyses in which mood and weight concerns were treated as time-dependent covariates were conducted in 2007 and 2009. By 24 weeks postpartum, 65% of women had resumed smoking. Smoking-related weight concerns increased risk of relapse, and positive affect and self-efficacy for weight management without smoking decreased risk of relapse postpartum. Moreover, after controlling for variables previously related to postpartum relapse, weight concerns remained significantly related to smoking relapse. Smoking-related weight concerns and positive affect increase the likelihood that a woman will resume smoking postpartum. Moreover, weight concerns appear to be salient even in the context of other factors shown to affect postpartum smoking. This study suggests that interventions may need to address women's weight concerns and mood to help sustain smoking abstinence after childbirth. Copyright © 2010 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  8. Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5.

    Directory of Open Access Journals (Sweden)

    Lin An

    Full Text Available Programmed cell death 5 (PDCD5 is a cytosolic protein suppressing growth of multiple types of cancer cells through activating p53. We hypothesized that PDCD5 plays an essential role in cardiac remodeling and function. PDCD5 was significantly up-regulated in the hearts from mice subjected to angiotensin II treatment or transverse aortic constriction. Thus, we generated transgenic mice over-expressing human PDCD5 under the control of alpha myosin heavy chain promoter to examine the role of PDCD5 in cardiac remodeling. Transgenic founder died spontaneously displayed enlarged heart. The high PDCD5 over-expressing line (10-fold showed reduced survival rate, increase in heart weight normalized to body weight. Real-Time RT-PCR analysis revealed fetal gene program was up-regulated. Echocardiography and histopathological examination showed characteristics of dilated cardiomyopathy and heart failure in transgenic mice. Western blot and immunohistochemistry analysis showed autophagy was dramatically increased in transgenic mice as compared to WT littermates control mice, while apoptosis remained unchanged. The enhanced autophagy in high over-expressing line was associated with significant increase in p53 activity and its downstream target damage-regulated autophagy modulator expression. The low over-expressing line (3.5-fold appeared normal, but was more susceptible to angiotensin II-induced cardiac hypertrophy. This study is the first providing evidence that PDCD5 plays an important role in cardiac remodeling.

  9. The More Things Change, the More They Are the Same: Continuing Concerns with the Special Olympics

    Science.gov (United States)

    Storey, Keith

    2008-01-01

    The Special Olympics has been a controversial program for persons with severe disabilities. There have been numerous discussion articles in the literature concerning pros and cons of the Special Olympics, and research has often found negative results concerning the Special Olympics. The purpose of this article is to review and to discuss concerns…

  10. 10 CFR 431.292 - Definitions concerning refrigerated bottled or canned beverage vending machines.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Definitions concerning refrigerated bottled or canned... EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL AND INDUSTRIAL EQUIPMENT Refrigerated Bottled or Canned Beverage Vending Machines § 431.292 Definitions concerning refrigerated bottled or canned beverage vending machines...

  11. Gender-Specific Barriers to Self-Sufficiency among Former Supplemental Security Income Drug Addiction and Alcoholism Beneficiaries: Implications for Welfare-To-Work Programs and Services.

    Science.gov (United States)

    Hogan, Sean R; Unick, George J; Speiglman, Richard; Norris, Jean C

    2011-01-01

    This study examines barriers to economic self-sufficiency among a panel of 219 former Supplemental Security Income (SSI) drug addiction and alcoholism (DA&A) recipients following elimination of DA&A as an eligibility category for SSI disability benefits. Study participants were comprehensively surveyed at six measurement points following the policy change. Generalized estimating equations were used to examine full-sample and gender-specific barriers to economic self-sufficiency. Results indicate that access to transportation, age, and time are the strongest predictors of achieving self-sufficiency for both men and women leaving the welfare system. Gender-specific barriers are also identified. Future research needs to assess the generalizability of these results to other public assistance recipients.

  12. Gender-Specific Barriers to Self-Sufficiency among Former Supplemental Security Income Drug Addiction and Alcoholism Beneficiaries: Implications for Welfare-To-Work Programs and Services

    Science.gov (United States)

    Hogan, Sean R; Unick, George J.; Speiglman, Richard; Norris, Jean C.

    2011-01-01

    This study examines barriers to economic self-sufficiency among a panel of 219 former Supplemental Security Income (SSI) drug addiction and alcoholism (DA&A) recipients following elimination of DA&A as an eligibility category for SSI disability benefits. Study participants were comprehensively surveyed at six measurement points following the policy change. Generalized estimating equations were used to examine full-sample and gender-specific barriers to economic self-sufficiency. Results indicate that access to transportation, age, and time are the strongest predictors of achieving self-sufficiency for both men and women leaving the welfare system. Gender-specific barriers are also identified. Future research needs to assess the generalizability of these results to other public assistance recipients. PMID:21625301

  13. Cluster Randomized Controlled Trial of An Aged Care Specific Leadership and Management Program to Improve Work Environment, Staff Turnover, and Care Quality.

    Science.gov (United States)

    Jeon, Yun-Hee; Simpson, Judy M; Li, Zhicheng; Cunich, Michelle M; Thomas, Tamsin H; Chenoweth, Lynn; Kendig, Hal L

    2015-07-01

    To evaluate the effectiveness of a leadership and management program in aged care. Double-blind cluster randomized controlled trial. Twelve residential and community-aged care sites in Australia. All care staff employed for 6 months or longer at the aged care sites were invited to participate in the surveys at 3 time points: baseline (time 1), 9 months from baseline (time 2), and 9 months after completion of time 2 (time 3) from 2011 to 2013. At each time point, at least 500 care staff completed a survey. At baseline (N = 503) the largest age group was 45 to 54 years (37%), and the majority of care staff were born in Australia (70%), spoke English (94%), and had at least completed secondary education (57%). A 12-month Clinical Leadership in Aged Care (CLiAC) program for middle managers, which aimed to further develop their leadership and management skills in creating positive workplace relationships and in enabling person-centered, evidence-based care. The primary outcomes were care staff ratings of the work environment, care quality and safety, and staff turnover rates. Secondary outcomes were care staff's intention to leave their employer and profession, workplace stress, job satisfaction, and cost-effectiveness of implementing the program. Absenteeism was excluded due to difficulty in obtaining reliable data. Managers' self-rated knowledge and skills in leadership and management are not included in this article, which focuses on care staff perceptions only. At 6 months after its completion, the CLiAC program was effective in improving care staff's perception of management support [mean difference 0.61, 95% confidence interval (CI) 0.04-1.18; P = .04]. Compared with the control sites, care staff at the intervention sites perceived their managers' leadership styles as more transformational (mean difference 0.30, 95% CI 0.09-0.51; P = .005), transactional (mean difference 0.22, 95% CI 0.05-0.39; P = .01), and less passive avoidant (mean difference 0.30, 95% CI 0

  14. The sensitivity and specificity of using a computer aided diagnosis program for automatically scoring chest X-rays of presumptive TB patients compared with Xpert MTB/RIF in Lusaka Zambia.

    Directory of Open Access Journals (Sweden)

    Monde Muyoyeta

    Full Text Available OBJECTIVE: To determine the sensitivity and specificity of a Computer Aided Diagnosis (CAD program for scoring chest x-rays (CXRs of presumptive tuberculosis (TB patients compared to Xpert MTB/RIF (Xpert. METHOD: Consecutive presumptive TB patients with a cough of any duration were offered digital CXR, and opt out HIV testing. CXRs were electronically scored as normal (CAD score ≤ 60 or abnormal (CAD score > 60 using a CAD program. All patients regardless of CAD score were requested to submit a spot sputum sample for testing with Xpert and a spot and morning sample for testing with LED Fluorescence Microscopy-(FM. RESULTS: Of 350 patients with evaluable data, 291 (83.1% had an abnormal CXR score by CAD. The sensitivity, specificity, positive predictive value (PPV and negative predictive value (NPV of CXR compared to Xpert were 100% (95%CI 96.2-100, 23.2% (95%CI 18.2-28.9, 33.0% (95%CI 27.6-38.7 and 100% (95% 93.9-100, respectively. The area under the receiver operator curve (AUC for CAD was 0.71 (95%CI 0.66-0.77. CXR abnormality correlated with smear grade (r = 0.30, p<0.0001 and with Xpert CT(r = 0.37, p<0.0001. CONCLUSIONS: To our knowledge this is the first time that a CAD program for TB has been successfully tested in a real world setting. The study shows that the CAD program had high sensitivity but low specificity and PPV. The use of CAD with digital CXR has the potential to increase the use and availability of chest radiography in screening for TB where trained human resources are scarce.

  15. The sensitivity and specificity of using a computer aided diagnosis program for automatically scoring chest X-rays of presumptive TB patients compared with Xpert MTB/RIF in Lusaka Zambia.

    Science.gov (United States)

    Muyoyeta, Monde; Maduskar, Pragnya; Moyo, Maureen; Kasese, Nkatya; Milimo, Deborah; Spooner, Rosanna; Kapata, Nathan; Hogeweg, Laurens; van Ginneken, Bram; Ayles, Helen

    2014-01-01

    To determine the sensitivity and specificity of a Computer Aided Diagnosis (CAD) program for scoring chest x-rays (CXRs) of presumptive tuberculosis (TB) patients compared to Xpert MTB/RIF (Xpert). Consecutive presumptive TB patients with a cough of any duration were offered digital CXR, and opt out HIV testing. CXRs were electronically scored as normal (CAD score ≤ 60) or abnormal (CAD score > 60) using a CAD program. All patients regardless of CAD score were requested to submit a spot sputum sample for testing with Xpert and a spot and morning sample for testing with LED Fluorescence Microscopy-(FM). Of 350 patients with evaluable data, 291 (83.1%) had an abnormal CXR score by CAD. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CXR compared to Xpert were 100% (95%CI 96.2-100), 23.2% (95%CI 18.2-28.9), 33.0% (95%CI 27.6-38.7) and 100% (95% 93.9-100), respectively. The area under the receiver operator curve (AUC) for CAD was 0.71 (95%CI 0.66-0.77). CXR abnormality correlated with smear grade (r = 0.30, p<0.0001) and with Xpert CT(r = 0.37, p<0.0001). To our knowledge this is the first time that a CAD program for TB has been successfully tested in a real world setting. The study shows that the CAD program had high sensitivity but low specificity and PPV. The use of CAD with digital CXR has the potential to increase the use and availability of chest radiography in screening for TB where trained human resources are scarce.

  16. Dealing with the problem of non-specific in situ mRNA hybridization signals associated with plant tissues undergoing programmed cell death

    Directory of Open Access Journals (Sweden)

    Jokela Anne

    2010-02-01

    Full Text Available Abstract Background In situ hybridization is a general molecular method typically used for the localization of mRNA transcripts in plants. The method provides a valuable tool to unravel the connection between gene expression and anatomy, especially in species such as pines which show large genome size and shortage of sequence information. Results In the present study, expression of the catalase gene (CAT related to the scavenging of reactive oxygen species (ROS and the polyamine metabolism related genes, diamine oxidase (DAO and arginine decarboxylase (ADC, were localized in developing Scots pine (Pinus sylvestris L. seeds. In addition to specific signals from target mRNAs, the probes continually hybridized non-specifically in the embryo surrounding region (ESR of the megagametophyte tissue, in the remnants of the degenerated suspensors as well as in the cells of the nucellar layers, i.e. tissues exposed to cell death processes and extensive nucleic acid fragmentation during Scots pine seed development. Conclusions In plants, cell death is an integral part of both development and defence, and hence it is a common phenomenon in all stages of the life cycle. Our results suggest that extensive nucleic acid fragmentation during cell death processes can be a considerable source of non-specific signals in traditional in situ mRNA hybridization. Thus, the visualization of potential nucleic acid fragmentation simultaneously with the in situ mRNA hybridization assay may be necessary to ensure the correct interpretation of the signals in the case of non-specific hybridization of probes in plant tissues.

  17. A Dutch day treatment program for anorexia and bulimia nervosa in comparison with internationally described programs.

    Science.gov (United States)

    Lammers, M W; Exterkate, C C; De Jong, C A J

    2007-03-01

    A Dutch day treatment program for patients with anorexia and bulimia nervosa is described and compared to intensive day treatment programs for patients with eating disorders outlined in international literature. The 5-day program is described in terms of its general characteristics, intended outcome and specific treatment interventions. Along these parameters it is compared to the programs found in a systematic literature search of day hospitalization programs for eating disorders. Global inspection shows a lot of similarities between all the programs. Looking more closely, also many important differences exist (concerning, e.g. treatment duration, intensity of treatment, theoretical orientation, goals of treatment and weight gain regime). Because of the differences, it is hard to compare outcome data between centres. Besides, on many of these dimensions, the literature does not yet tell us unambiguously what is best for our patients. Therefore, it is necessary to keep the dialogue between treatment centres going. 2007 John Wiley & Sons, Ltd and Eating Disorders Association

  18. Effectiveness of Selected Advanced Placement Programs on the Academic Performance and College Readiness of High School Students

    Science.gov (United States)

    Lewis, Traschell S.

    2012-01-01

    The purpose of this study was to examine the effectiveness of selected Advanced Placement (AP) programs on the academic performance and college readiness of high school students. Specifically, the researcher was concerned with ascertaining the effectiveness of social science, math, science, English, music/art and language AP programs on the…

  19. AN ANALYSIS OF CIVIL AERONAUTICS BOARD POLICY CONCERNING AIRLINE MERGERS.

    Science.gov (United States)

    The study determines and analyzes the Civil Aeronautics Board’s policy concerning airline mergers . This is accomplished by: (1) tracing the...evolution of statutory authority granted the Board to regulate airline mergers ; (2) analyzing specific decisions of the Board to determine Board policy...condition of the carriers involved in the mergers . Conclusions are that (1) the CAB was given statutory authority by Congress because of realization that

  20. Development of the body image concern inventory.

    Science.gov (United States)

    Littleton, Heather L; Axsom, Danny; Pury, Cynthia L S

    2005-02-01

    Development of the Body Image Concern Inventory (BICI), a measure designed to assess dysmorphic concern, is described. A panel of expert raters supported the construct validity of the measure, and four college student samples (Ns=184, 200, 56, 40) supported the internal consistency of the BICI. In addition, in studies 1 and 3, concurrent validity was established through comparison of the BICI to extant self-report and interview measures of dysmorphic symptomatology. Convergent validity patterns were assessed through comparison with measures of obsessive-compulsive and eating disorder symptomatology in studies 2 and 4. Finally, the results of study 4 supported that the BICI discriminated individuals with a diagnosis of Body Dysmorphic Disorder or bulimia (disorders that frequently involve high levels of dysmorphic concern) from those with subclinical symptoms. Results suggest that the BICI is a reliable, valid, and user-friendly tool for assessing dysmorphic concern, with utility in both research and clinical settings.

  1. The Auditor's Going-Concern Opinion Decision

    National Research Council Canada - National Science Library

    Tae G Ryu; Chul-Young Roh

    2007-01-01

    In this study, we expand on several previous studies related to the materiality judgments and the auditor's propensity to issue a going-concern opinion to financially troubled but non-bankrupt companies...

  2. Hand Swelling during Exercise: A Concern?

    Science.gov (United States)

    Hand swelling during exercise: A concern? What causes hand swelling during exercise? I walk several times a ... off. Answers from Edward R. Laskowski, M.D. Hand swelling during exercise is a fairly common problem. ...

  3. Community-based health insurance knowledge, concern ...

    African Journals Online (AJOL)

    Community-based health insurance knowledge, concern, preferences, and financial planning for health care among informal sector workers in a health district of Douala, Cameroon. JJN Noubiap, WYA Joko, JMN Obama, JJR Bigna ...

  4. Tourette Syndrome (TS): Other Concerns and Conditions

    Science.gov (United States)

    ... Conditions Language: English (US) Español (Spanish) Recommend on Facebook Tweet Share Compartir On This Page ADHD Obsessive-Compulsive Behaviors Behavior or Conduct Problems Anxiety Depression Other Health Concerns Educational Tourette Syndrome (TS) often ...

  5. Other Safety Concerns and Self-Neglect

    Science.gov (United States)

    ... Research Into Practice Exploitation Resources Webinars Core APS Competencies Technical Assistance Briefs Get Connected Join Now Annual ... Other Safety Concerns Case Study Code of Ethics Strategic Plan Board & Staff Committees Research Committee Partners Certificate ...

  6. Foot Swelling during Air Travel: A Concern?

    Science.gov (United States)

    ... concern? What causes leg and foot swelling during air travel? Answers from Sheldon G. Sheps, M.D. ... had major surgery or you take birth control pills, for example — consult your doctor before flying. He ...

  7. Going Concern i revisionsprocessen [del 1

    DEFF Research Database (Denmark)

    Hartmann, Stig; Haraszuk, Anni

    2012-01-01

    Nærværende artikel er den første af to planlagte, der vil blive bragt i Revision & Regnskabsvæsen. Det er artiklernes overordnede ide at besvare følgende spørgsmål: Hvad er nøgleelementerne i god revisorskik anno 2012 i forhold til Going Concern vurdering i revisionsprocessen? Hvordan eksekveres...... god revisorskik i forhold til Going Concern i 2012 samt 2013 og fremadrettet? Hvem er nøgleinteressenterne og hvilken roller spiller de i udviklingen af god revisorskik, indenfor Going Concern i erklæringer med høj grad af sikkerhed? Hvordan kan revisionsvirksomhedens interne kvalitetsstyringssystem...... designes i forhold til Going Concern for at leve op til god revisorskik, samtidigt med at revisor skal drive en fornuftig forretning?...

  8. Dissatisfied consumers' complaint behaviour concerning product ...

    African Journals Online (AJOL)

    BlignautAS

    Dissatisfied consumers' complaint behaviour concerning product failure of major ... for product performance with perceived product per- ... understanding of consumers' post-purchase behav- .... influenced consumers' intention to seek redress.

  9. Chronic Diarrhea: A Concern After Gallbladder Removal?

    Science.gov (United States)

    Chronic diarrhea: A concern after gallbladder removal? I had my gallbladder removed six months ago, and I'm ... Barkun A, et al. Bile acid malabsorption in chronic diarrhea: Pathophysiology and treatment. Canadian Journal of Gastroenterology. 2013; ...

  10. Environmental concerns of supply chain sustainability (SCS)

    Science.gov (United States)

    Mokhtar, Mohd Faiz; Omar, Badrul; Nor, Nik Hisyamudin Muhd; Pauzi, Nur Fazlinda Mohd; Hasan, Sulaiman; Mohamed, W. A. Wan

    2017-04-01

    Environment concern is one important aspect for supply chain sustainability (SCS). Nowadays, company's activities give a lot of impact on the environment. Through these activities, there are other SCS issue of environment were identified. In this paper, the proposed SCS issue of environmental concern will be determined from Corporate Sustainability Report (CSR). Using a total weightage of 0.333 (after dividing into three aspects of sustainability), each proposed issues will be classified according to the company activities in order to determined weightage for each issue. Those weightages then will be used in developing of score metric for SCS in design phase. Result shows that the carbon footprint is the major concern for SCS of environment while environmental management system is a lowest concern for SCS environment.

  11. Political, economic and environmental concerns: discussion

    Science.gov (United States)

    Skinner, Guy C. G.; Dear, Felicity F.

    2017-06-01

    This session concerned the political, economic and environmental impact on the hydrogen economy due to hydrogen embrittlement. This article is part of the themed issue 'The challenges of hydrogen and metals'.

  12. Master’s Students in an Information Studies Program Enter the Program with Excitement and Leave with Concerns about Professional Preparation for their Chosen Fields. A Review of: Cherry, J. M., Duff, W. M., Singh, N., & Freund, L. (2011. Student perceptions of the information professions and their master's program in information studies. Library & Information Science Research, 33(2, 120-131. doi:10.1016/j.lisr.2010.09.004

    Directory of Open Access Journals (Sweden)

    Christina E. Carter

    2011-01-01

    Full Text Available Objective – To assess master’s students’ perceptions of their information studies program with regard to the program’s academic quality and professional preparation as it moved to become an iSchool.Design – Longitudinal survey, employing both quantitative analysis of demographics and closed responses, and thematic analysis of open-ended responses.Setting – University of Toronto, Canada, Faculty of Information, Master of Information Studies (MISt ALA-accredited program.Subjects – Students enrolled in the MISt program from fall 2003 to spring 2007.Methods – Between 2003 and 2007, a self-administered confidential questionnaire was distributed eight times: a short version of the questionnaire to incoming students in the fall term over the four years, and a longer version to the entire MISt student body in the spring term of the four years. Thus, individual students participated in the survey multiple times. Survey questions fell into four categories: program assessment, perceptions on the information professions, career and personal achievements, and demographics. The first questionnaire was mailed in paper form; after that, Web-based questionnaires were used. Quantitative data collected was analyzed using SPSS, version 17, and open-ended responses were examined for recurring themes.Main Results – Across the four years of the survey, researchers obtained about 1,000 completed questionnaires. The response rate was always higher in the fall term than in the spring term, ranging from a high of 67% in fall 2003, to a low of 47% in spring 2007 which seemed to indicate “fatigue” with the study (p. 124. Respondents primarily were interested in the information professions and the majority planned to work in one of them (archives, library systems, or library and information science after graduating. No statistically significant differences relating to the year the survey was completed were found for student perceptions of career

  13. CONCERNING AGRICULTURAL EDUCATION PROGRESS IN RUSSIA

    Directory of Open Access Journals (Sweden)

    Elena N. Akhapkina

    2015-01-01

    Full Text Available The concept of a network of educational institutions as one of the causes that negatively aff ect the competitiveness of higher education inRussia, directly points to the narrow realm of training in a particular area. There is a danger of destruction of branch universities in the existing system of higher education. Meanwhile, studies of the real value of specialized higher education in our country, and the reasons for determining this value is not enough, and the available knowledge is fragmented. In the article on the example of high schools of the Ministry of Agriculture ofRussiaproved that a specialized education can become a decisive factor in improving the quality of human capital, the development of the industry areas of the state. There are at least several reasons that indicate the need to stimulate the development processes of every kind of agricultural universities. The first reason has to do with the movement of the world community towards the reorganization of the national systems of higher education, where the central place is given to the development of specialized training programs. It should be particularly emphasized that higher education around the world is no longer the subject of domestic policy. Universities are fighting for the education market, and the availability of specialized educational programs has a decisive importance in this struggle. In addition, the authors say, in the Russian context agrarian universities are able to become a guarantor of the development of rural areas, helping to overcome the social consequences of reform of the agricultural sector. Another reason is related to the specificity of the educational process in agricultural universities and answers the question why agricultural education is a special form of organization of educational process, which is closely related to the agricultural sector of the country. Studies conducted by the authors suggest that the destruction of the existing system of

  14. Derivation of sorting programs

    Science.gov (United States)

    Varghese, Joseph; Loganantharaj, Rasiah

    1990-01-01

    Program synthesis for critical applications has become a viable alternative to program verification. Nested resolution and its extension are used to synthesize a set of sorting programs from their first order logic specifications. A set of sorting programs, such as, naive sort, merge sort, and insertion sort, were successfully synthesized starting from the same set of specifications.

  15. Symptom specificity in the acute treatment of Major Depressive Disorder: a re-analysis of the treatment of depression collaborative research program.

    Science.gov (United States)

    Stewart, Jeremy G; Harkness, Kate L

    2012-03-01

    Antidepressant medications, Cognitive-Behavioral Therapy (CBT) and Interpersonal Psychotherapy (IPT) are equally efficacious in the acute treatment of Major Depressive Disorder (MDD). Nevertheless, remission rates remain unacceptably low. Examining the differential time course of remission of specific symptom clusters across treatments may provide a basis for assigning patients to treatments that have the highest chance of being effective. This study re-analyzed data from the NIMH Treatment of Depression Collaborative Research Project (TDCRP), which included 250 adult outpatients with MDD randomized to 16 weeks of CBT, IPT, imipramine+clinical management (IMI-CM), or pill placebo (PLA-CM). We derived four symptom factors from the 23-item Hamilton Depression Rating Scale, and three symptom factors from the Beck Depression Inventory. Within-subject hierarchical regression models were specified to examine the linear and quadratic patterns of symptom remission over five assessment points. IMI-CM produced a more rapid rate of remission than CBT or IPT for both the somatic/vegetative and cognitive-affective symptoms of MDD. There were no statistically significant differences in the rates of improvement of any of the symptom factors between the IMI-CM and PLA-CM groups. Some core symptoms of depression were excluded due to low factor loadings. Past research has argued that the CBT arm in the TDCRP may have been weak. We failed to find evidence that treatments act preferentially on specific symptom clusters. Therefore, the symptoms of MDD may be inter-dependent when it comes to their courses of remission in treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  16. Specificity of specific language impairment

    NARCIS (Netherlands)

    GoorhuisBrouwer, SM; WijnbergWilliams, BJ

    1996-01-01

    In children with specific language impairment (SLI) their problems are supposed to be specifically restricted to language. However, both on a theoretical basis as well as on a practical basis it is often difficult to make a sharp distinction between specific and nonspecific language disorders. In a

  17. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2009-01-01

    Make cool stuff. If you're a designer or artist without a lot of programming experience, this book will teach you to work with 2D and 3D graphics, sound, physical interaction, and electronic circuitry to create all sorts of interesting and compelling experiences -- online and off. Programming Interactivity explains programming and electrical engineering basics, and introduces three freely available tools created specifically for artists and designers: Processing, a Java-based programming language and environment for building projects on the desktop, Web, or mobile phonesArduino, a system t

  18. Alien Species of EU Concern in Romania

    Directory of Open Access Journals (Sweden)

    Anastasiu Paulina

    2017-07-01

    Full Text Available Of the 37 species of the European Union concern eight are already present and two present a future potential risk for Romania. This paper brings updated information regarding these species in Romania. The presence of eight invasive alien species of concern to the European Union have already been recorded in Romania: two plant species Cabomba caroliniana and Heracleum sosnowskyi, two crustaceans Orconectes limosus and Eriocheir sinensis, two fish species Pseudorasbora parva and Perccottus glenii, one reptile Trachemys scripta and one mammal Myocastor coypus. Other two species of Union concern (Lithobates catesbeianus and Procyon lotor may soon become invaders in Romania. We emphasize the urgent need to assess their current distribution and impact or potential to establish and possible impact at national level.

  19. Issues concerning the light-duty diesel

    Energy Technology Data Exchange (ETDEWEB)

    Clusen, Ruth C.

    1979-09-01

    The current reasons for concern about the diesel engine for light-duty vehicles are explained, and an overview of the major issues impacting upon future diesel-related policy considerations is presented. Light-duty diesels are of immediate concern because proposed environmental legislation could impact upon their market future as early as model year 1981. The environmental issues affecting these vehicles also have implications for other categories of diesels (heavy-duty mobile and stationary application). Part I presents background and overview information on the reasons for the diesel's emergence as a major concern in the regulatory area and Part II summarizes the issues surrounding the diesel in three major areas: protecting health and the environment; fuel conservation; and broad economic and programmaic trade-offs arising from the previous two areas.

  20. TSCA Section 5(b)(4) Concern List

    Science.gov (United States)

    EPA's existing chemicals programs address pollution prevention, risk assessment, hazard and exposure assessment and/or characterization, and risk management for chemicals substances in commercial use.

  1. 3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.

    Science.gov (United States)

    Konstantakou, Eumorphia G; Voutsinas, Gerassimos E; Velentzas, Athanassios D; Basogianni, Aggeliki-Stefania; Paronis, Efthimios; Balafas, Evangelos; Kostomitsopoulos, Nikolaos; Syrigos, Konstantinos N; Anastasiadou, Ema; Stravopodis, Dimitrios J

    2015-07-22

    Urinary bladder cancer is one of the most fatal and expensive diseases of industrialized world. Despite the strenuous efforts, no seminal advances have been achieved for its clinical management. Given the importance of metabolic reprogramming in cancer cell survival and growth, we have herein employed 3-BrPA, a halogenated derivative of pyruvate and historically considered inhibitor of glycolysis, to eliminate bladder cancer cells with highly oncogenic molecular signatures. Bladder cancer cells were exposed to 3-BrPA in the absence or presence of several specific inhibitors. Cell viability was determined by MTT and flow-cytometry assays; cell death, signaling activity and metabolic integrity by Western blotting and immunofluorescence; mutant-gene profiling by DNA sequencing; and gene expression by RT-sqPCR. 3-BrPA could activate dose-dependent apoptosis (type 1 PCD) and regulated necrosis (type 3 PCD) of T24 (grade III; H-Ras(G12V); p53(ΔY126)), but not RT4 (grade I), cells, with PARP, MLKL, Drp1 and Nec-7-targeted components critically orchestrating necrotic death. However, similarly to RIPK1 and CypD, p53 presented with non-essential contribution to 3-BrPA-induced cellular collapse, while reactivation of mutant p53 with PRIMA-1 resulted in strong synergism of the two agents. Given the reduced expression of MPC components (likely imposing mitochondrial dysfunction) in T24 cells, the suppression of constitutive autophagy (required by cells carrying oncogenic Ras; also, type 2 PCD) and derangement of glucose-homeostasis determinants by 3-BrPA critically contribute to drug-directed depletion of ATP cellular stores. This bioenergetic crisis is translated to severe dysregulation of Akt/FoxO/GSK-3, mTOR/S6, AMPK and MAPK (p44/42, p38 and SAPK/JNK) signaling pathways in 3-BrPA-treated T24 cells. Sensitivity to 3-BrPA (and tolerance to glucose deprivation) does not rely on B-Raf(V600E) or K-Ras(G13D) mutant oncogenic proteins, but partly depends on aberrant signaling

  2. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    To innovate, firms require their employees to develop novel ideas and to coordinate with each other to turn these ideas into products, services or business strategies. Because the quality of implemented designs that employees are associated with affects their labor market opportunities, career...... concerns arise that can both be ‘good’ (enhancing incentives for effort in developing ideas) and ‘bad’ (preventing voluntary coordination). Depending on the strength of career concerns, either group-based incentives or team production are optimal. This finding provides a possible link between the increased...... use of teams and changes in labor market returns to skills....

  3. Otologic and Audiology Concerns of Microtia Repair.

    Science.gov (United States)

    Ali, Kausar; Mohan, Kriti; Liu, Yi-Chun

    2017-08-01

    Microtia is a congenital auricular deformity that commonly presents with associated congenital aural atresia. The most acute concern in these patients is concomitant hearing loss at birth. A team-based approach by plastic surgeons and otologists is necessary to address both the otologic and audiologic concerns of microtia and atresia. Hearing rehabilitation is imperative; yet it should not compromise the aesthetic components of reconstruction and vice versa. Here, the authors propose a framework to evaluate and manage patients with microtia and atresia with the goal of optimizing functional and cosmetic outcomes.

  4. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    2010-01-01

    A firm's innovation process requires employees to develop novel ideas and to coordinate with each other to turn the tacit knowledge embodying these ideas into better products and services. Such work outcomes provide signals about employees' abilities to the labor market, and therefore career...... concerns arise. The effects of career concerns can both be 'good' (enhancing incentives for effort in developing ideas) and 'bad' (preventing voluntary coordination). Our model shows how a firm can take these conflicting forces into account through the design of its explicit incentive system and the way...

  5. Career concerns incentives: An experimental test

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht; Raab, Philippe

    2009-01-01

    Holmström's (1982/99) career concerns model has become a workhorse for analyzing agency issues in many elds. The underlying signal jamming argument requires players to use information in a Bayesian way, which is difficult to directly test with eld data: typically little is known about the informa......Holmström's (1982/99) career concerns model has become a workhorse for analyzing agency issues in many elds. The underlying signal jamming argument requires players to use information in a Bayesian way, which is difficult to directly test with eld data: typically little is known about...

  6. How specific are specific phobias?

    Science.gov (United States)

    Hofmann, S G; Lehman, C L; Barlow, D H

    1997-09-01

    To study the generality of fears among specific phobic individuals and controls, 31 individuals with a DSM-IV diagnosis of specific phobia (natural environmental type: n = 13; blood-injection-injury type: n = 10; and situational type: n = 8) and 33 never mentally ill control subjects participated in an interview and questionnaire study. Based on subjects' fear ratings on the Fear Survey Schedule, subjects were classified as either positive or negative with regard to fear categories that correspond to the five diagnostic subtypes of specific phobia. Phobics showed overall a more generalized form of fear than controls. Furthermore, situational fears were more common among specific phobics who did not meet criteria for specific phobia, situational type, than among controls. These results add to the literature on the functional relationship among different fears and suggest that specific phobias are not as "specific" as is implied by the current diagnostic system.

  7. Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other Gq-coupled receptors.

    Science.gov (United States)

    Becker, Jérôme A J; Mirjolet, Jean-François; Bernard, Jérôme; Burgeon, Emmanuel; Simons, Marie-Jeanne; Vassart, Gilbert; Parmentier, Marc; Libert, Frédérick

    2005-01-21

    GPR54 is a receptor for peptides derived from the metastasis suppressor gene KiSS-1. To investigate the intracellular mechanisms involved in the reduction of the metastatic potential of MDA-MB-435S cells expressing GPR54, a time course stimulation by kisspeptin-10 over a period of 25 h was performed using cDNA microarrays. Comparison with the bradykinin B(2) receptor revealed a distinct pattern of gene regulation despite a common coupling to the G(q/11) class of G-proteins. Inhibitors of PLC and PK-C abolished the transcriptional regulation of all tested genes, while an inhibitor of p42/44 affected a subset of genes controlled both by GPR54 and B(2). Among the genes specifically up-regulated by GPR54, we found several proapoptotic genes. Stimulation of GPR54 promoted apoptosis while no significant change was observed after B(2) receptor activation. Our results suggest that the metastasis suppressor properties of GPR54 are mediated in part by cell cycle arrest and induction of apoptosis in malignant cells.

  8. The long-term lasting effectiveness on self-efficacy, attribution style, expression of emotions and quality of life of a body awareness program for chronic a-specific psychosomatic symptoms.

    Science.gov (United States)

    Landsman-Dijkstra, Jeanet J A; van Wijck, Ruud; Groothoff, Johan W

    2006-01-01

    A 3-day residential body awareness program (BAP) was developed to teach people with chronic a-specific psychosomatic symptoms (CAPS) to react adequately to disturbances of the balance between a daily workload and the capacity to deal with it. The long-term effects of the program on body awareness, psychological factors, psychosomatic symptoms and quality of life for people with CAPS are presented in this study. A pre-post design is used with post-measures 2 and 12 months after the program, without controls (n = 122). Mean age is 42.5 (S.D. = 9.0) and 60% is female. The results showed an increase of body awareness, self-efficacy, expression of emotions and quality of life. Stress-related symptoms decreased and the attribution style was found to be less depressive. Participants achieved significantly higher levels of functioning at 2 months which increased significantly more at 12 months. The majority of the measured changes can be interpreted as clinically relevant outcomes with medium-to-large effect sizes. Spouses of the participants also confirm the found effects. Evaluation of the BAP gives evidence to conclude that this program leads to the theoretically expected long-term effects in CAPS. Participants react more adequately to disturbances between daily workload and the capacity to deal with this load. Two and 12 months after the 3-day program, they are more capable of self-management in coping with stress and psychosomatic symptoms. This article sheds new light on the difficulties that individuals with psychosomatic symptoms and their professional interventionists encounter when attempting to manage the chronicity of the problems. By paying more attention to learning self-management by increasing body awareness and self-efficacy, patient educators may be able to increase their effectiveness.

  9. 48 CFR 219.1203 - Incentive subcontracting with small disadvantaged business concerns.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Incentive subcontracting... BUSINESS PROGRAMS Small Disadvantaged Business Participation Program 219.1203 Incentive subcontracting with small disadvantaged business concerns. The contracting officer shall encourage increased subcontracting...

  10. Status of neotropical migrant landbirds in the Midwest: identifying species of management concern

    Science.gov (United States)

    Frank R. Thompson; Stephen J. Lewis; Janet D. Green; David N. Ewert

    1993-01-01

    We ranked species of neotropical migrant landbirds by decreasing management concern for their viability in the Midwest. This was part of a coordinated effort by regional working groups of the Partners In Flight Program, an interagency program for the conservation of neotropical migratory birds (NTMBs). Species were ranked by seven criteria, developed by working group...

  11. The kinetics of transcriptomic changes induced by cigarette smoke in rat lungs reveals a specific program of defense, inflammation, and circadian clock gene expression.

    Science.gov (United States)

    Gebel, Stephan; Gerstmayer, Bernhard; Kuhl, Peter; Borlak, Jürgen; Meurrens, Kris; Müller, Thomas

    2006-10-01

    Gene expression profiling in animal models exposed to cigarette mainstream smoke (CS) shapes up as a promising tool for investigating the molecular mechanisms involved in the onset and development of CS-related disease and may aid in the identification of disease candidate genes. Here we report on differential gene expression in lungs of rats exposed for 2, 7, and 13 weeks to 300 and 600 microg total particulate matter/l CS with sacrifice 2, 6, or 20 h after the last exposure. Regarding antioxidant and xenobiotic-metabolizing (phase I/II) enzymes, a stereotypic, mostly transient, expression pattern of differentially expressed genes was observed after each exposure period. The expression patterns were generally dose dependent for antioxidant and phase II genes and not dose dependent for phase I genes at the CS concentrations tested. However, with increasing length of exposure, there was a distinct, mostly sustained and dose-sensitive, expression of genes implicated in innate and adaptive immune responses, clearly pointing to an emerging inflammatory response. Notably, this inflammatory response included the expression of lung disease-related genes not yet linked to CS exposure, such as galectin-3, arginase 1, and chitinase, as well as genes encoding proteolytic enzymes. Finally, our experiments also revealed a CS exposure-dependent shift in the cyclical expression of genes involved in controlling the circadian rhythm. Altogether, these results provide further insight into the molecular mechanisms of CS-dependent disease onset and development and thus may also be useful for defining CS-specific molecular biomarkers of disease.

  12. Prostate-Specific Antigen testing in men between 40 and 70 years in Brazil: database from a check-up program

    Directory of Open Access Journals (Sweden)

    João Paulo Zambon

    2014-12-01

    Full Text Available Objectives To evaluate the PSA in a large population of Brazilian men undergone to check up, and correlate the PSA cutoffs with prostate size and urinary symptoms. Materials and Methods This is a cross sectional study performed with men between 40 and 70 years undergone to check-up. All men were undergone to urological evaluation, digital rectal examination, prostate-specific antigen, and ultrasonography The exclusion criteria were men who used testosterone in the last six months, or who were using 5 alpha-reductase inhibitors. Results A total of 5015 men with an average age of 49.0 years completed the study. Most men were white and asymptomatic. The PSA in the three different aging groups were 0.9 ± 0.7ng/dL for men between 40 and 50; 1.2 ± 0.5ng/dL for men between 50 and 60; and 1.7 ± 1.5ng/dL for men greater than 60 years (p=0.001. A total of 192 men had PSA between 2.5 and 4ng/ml. From these men 130 were undergone to prostate biopsy. The predictive positive value of biopsy was 25% (32/130. In the same way, 100 patients had PSA >4ng/mL. From these men, 80 were undergone to prostate biopsy. In this group, the predictive positive value of biopsy was 40% (32/100. The Gleason score was 6 in 19 men (60%, 7 in 10 men (31% and 8 in 3 men (9%. Conclusions The PSA level of Brazilian men undergone to check up was low. There was a positive correlation with aging, IPSS and prostate size.

  13. Health Occupations Education: A Survey of Concerns.

    Science.gov (United States)

    Shea, Mary Lou

    1983-01-01

    Employers from 13 different health care settings in Illinois responded to a questionnaire to identify major issues affecting health occupations education. The five major concerns of employers were the need for improved communication between educational and service institutions, improved understanding of roles, overspecialization, lack of regional…

  14. The Growing Concerns Regarding School Resource Officers

    Science.gov (United States)

    Ryan, Joseph B.; Katsiyannis, Antonis; Counts, Jennifer M.; Shelnut, Jill C.

    2018-01-01

    There have been an increasing number of incidents in which school resource officers (SRO) have been used to manage student disciplinary issues with disastrous results. Court cases brought by parents and advocacy groups claim SROs have traumatized and injured students. This article addresses several critical issues concerning SROs being used to…

  15. Modeling traceability of concerns in architectural views

    NARCIS (Netherlands)

    Tekinerdogan, B.; Hofmann, C.; Aksit, Mehmet

    2007-01-01

    Software architecture modeling includes the description of different views that represent the architectural concerns from different stakeholder perspectives. In case of evolution of the software system the related architectural views need to be adapted accordingly. For this it is necessary that the

  16. FACTORS INFLUENCING AUDITORS' GOING CONCERN OPINION

    Directory of Open Access Journals (Sweden)

    Hasnah Haron

    2009-01-01

    Full Text Available The main purpose of our study is to provide evidence the practically consideration of auditor judgement on going concern opinion. By using quasi experimental, we found strong evidence that auditors' judgement is affected by financial indicators, evidence, and disclosure. We have another finding that consensus among auditors' judgement and the interaction effects between the three independent variables is significant.

  17. Ethical Concerns: Negotiating Truth and Trust

    Science.gov (United States)

    McGarvey, Lynn M.; Sterenberg, Gladys

    2009-01-01

    Few studies in mathematics education explicitly address ethical issues arising from student interactions. The ethical concerns held by students are expressed in their words, actions, and interactions. The purpose of this article is to explore the ethical nature of copying as it arises in a mathematics classroom. We investigate the basis for…

  18. Future Concerns for Applied Sport Psychology.

    Science.gov (United States)

    Duda, Joan L.

    1982-01-01

    Several concerns should be addressed before the field of sport pschology can have its greatest impact: (1) careful study and evaluation in this new field; (2) broadening of field and its application to various physical settings and participants; and (3) roles of responsibility defined for coaches and sport psychologists in psychological…

  19. 78 FR 23247 - Policy Statement Concerning Assistance

    Science.gov (United States)

    2013-04-18

    .... \\25\\ In a liquidity crisis situation, the Corporation would work with the System banks to ensure the... CORPORATION Policy Statement Concerning Assistance AGENCY: Farm Credit System Insurance Corporation. ACTION: Policy statement. SUMMARY: The Farm Credit System Insurance Corporation (Corporation or FCSIC) announces...

  20. Adolescent Homosexuality and Concerns Regarding Disclosure.

    Science.gov (United States)

    Harrison, Therese W.

    2003-01-01

    With threats of being labeled abnormal or facing rejection, homosexual adolescents are pressured to hide their sexual identities. To provide optimal anticipatory guidance and support, professionals must understand the natural development of sexual attraction and the disclosure concerns and risks for developing homosexual adolescents (e.g., risk…

  1. Understanding Teachers' Concerns about Inclusive Education

    Science.gov (United States)

    Yadav, Monika; Das, Ajay; Sharma, Sushama; Tiwari, Ashwini

    2015-01-01

    This study examined the concerns of regular elementary school teachers in Gurgaon, India, in order to work with students with disabilities in inclusive education settings. A total of 175 teachers responded to a two-part questionnaire. Data were analyzed using descriptive and inferential statistics. The data indicated that the teachers in Gurgaon,…

  2. Environmental concern and environmentally responsible behaviour ...

    African Journals Online (AJOL)

    In this study, environmental concern has been conceptualised as the manifestation of attitudes that are directed at behavioural intentions of active personal involvement in caring about environmental matters. Based on a critique of theoretical approaches towards understanding the formation of environmental attitudes, ...

  3. Counseling Concerns for the Individual with Bulimia.

    Science.gov (United States)

    Leclair, Norma J; Berkowitz, Belinda

    1983-01-01

    Presents characteristics, medical concerns, treatment alternatives, and family issues for counselors working with nonhospitalized clients. Emphasis is placed on attending the interaction of the behavioral, cognitive, and affective domains in the client. Counselors should use interventions based on theory and research. (Author/JAC)

  4. The Philosopher's Concern with Language and Communication

    African Journals Online (AJOL)

    Ike Odimegwu

    ... a fellow Englishman, John. Locke, (better known for his theory of Social Contract). In his book, Essay Concerning Human Understanding (1990),. Locke articulated a far-reaching and ramified theory of logico-linguistic analysis geared towards efficient language and communication. In his logico-linguistic analysis, Locke.

  5. Health Needs and Concerns of Male Adolescents.

    Science.gov (United States)

    Pinch, Winifred J.; And Others

    1986-01-01

    Examined male college students' (N=159) concerns in the areas of alcohol and other drug use, automobile safety, weight and dieting, smoking, sexuality, coping and stress, and selection and utilization of health care services. Identified major problems with alcohol use, automobile safety, weight control, stress, and sexuality. Also identified…

  6. Software Architecture : Framing Stakeholders' Concerns introduction

    NARCIS (Netherlands)

    Lago, Patricia; Avgeriou, Paris; Hilliard, Rich

    2010-01-01

    As noted earlier, some stakeholder concerns are well-served today by available architecture viewpoints, frameworks, or ADLs, while others aren't expressible with available, off-the-shelf approaches. Hence the theme of this special issue: exploring the space of architecting in the face of multiple

  7. Concerns about Teaching Process: Student Teachers' Perspective

    Science.gov (United States)

    Cakmak, Melek

    2008-01-01

    The aim of this study is to determine the student teachers' concerns about the teaching process including the teaching profession, teaching methods, planning, instruction, evaluation and classroom management. A total of 156 student teachers from five departments in the Gazi faculty of education participated in the study. A questionnaire including…

  8. Flying blind in anesthesia: A safety concern.

    Science.gov (United States)

    Aqil, Mansoor; Khan, Mueenullah; Saeed, Abdulhamid Al; Alzahrani, Tariq

    2014-07-01

    We describe two cases of sudden loss of display of all the monitors of Zeus anesthesia work station during operation, which is a major safety concern. Flying blind in anesthesia could be devastating. These cases attempt to highlight the need for greater vigilance by anesthesiologists and have implications for improvement in technology.

  9. Flying blind in anesthesia: A safety concern

    Directory of Open Access Journals (Sweden)

    Mansoor Aqil

    2014-01-01

    Full Text Available We describe two cases of sudden loss of display of all the monitors of Zeus anesthesia work station during operation, which is a major safety concern. Flying blind in anesthesia could be devastating. These cases attempt to highlight the need for greater vigilance by anesthesiologists and have implications for improvement in technology.

  10. Systems Analysts in Higher Education: Some Concerns.

    Science.gov (United States)

    Alden, John W.

    This paper focuses on the concerns associated with the use of systems analysis in higher education. One fear is that systems analysis will increase the need for centralized authority and highly structured activity, thus contributing to further alienation and dehumanization. A second objection pertains to the increased requirement for specifying…

  11. Emergency Preparedness Concerns for Older Adults

    Centers for Disease Control (CDC) Podcasts

    2009-01-26

    This podcast discusses the special concerns many older adults face during a disaster. It is primarily targeted to public health and aging services professionals.  Created: 1/26/2009 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) and Coordinating Office for Terrorism Preparedness and Emergency Response (COTPER).   Date Released: 1/26/2009.

  12. Separation of Concerns and Then What?

    DEFF Research Database (Denmark)

    Ernst, Erik

    2000-01-01

    Separation of concerns by explicit aspectualization is but one tool in a more complex toolbox. In particular, integration of separately expressed aspects must also be considered, and this integration may be so tight that the aspects cannot be expressed fully independently in the rst place. This g...

  13. Behavior Analytic Consultation for Academic Referral Concerns

    Science.gov (United States)

    Dufrene, Brad A.; Zoder-Martell, Kimberly A.; Dieringe, Shannon Titus; Labrot, Zachary

    2016-01-01

    Applied behavior analysis provides a technology of human behavior that demonstrates great potential for improving socially important outcomes for individuals. School-based consultation may provide a vehicle for delivering applied behavior analysis services in schools to address academic referral concerns. In this article, we propose that…

  14. Online privacy concerns and legal assurance: A user perspective

    Directory of Open Access Journals (Sweden)

    Hanna Krasnova

    2013-02-01

    Full Text Available With the emergence of the internet vast amounts of information became available to a broad and growing interconnected public. While the ever increasing access to knowledge is certainly a laudable achievement of the World Wide Web, the unprecedented amount of data exchange, sharing and storage also brought about a whole new set of legal challenges, particularly with regards to data protection. Based on an online survey with 553 students and staff at a major German university, the following article sheds light on the question of how far users are informed and concerned about their privacy when surfing the web. More specifically, the article addresses the following three questions: what is the nature of users’ privacy concerns when using the internet in general and Facebook in particular? What are users’ attitudes towards legal assurances? And how willing are users to take a more active role in their privacy protection?

  15. Examining Influences on Environmental Concern and Career Choice among a Cohort of Environmental Scientists

    Science.gov (United States)

    Wright, Tarah S. A.; Wyatt, S. Lilith

    2008-01-01

    Although there is considerable literature discussing influence of environmental concern in the general population, and some literature specific to certain populations, to date there has not been a study that investigates the influences on environmental concern and career path for environmental scientists. With complex environmental issues becoming…

  16. Watchdog Audits Environmental Programs

    Science.gov (United States)

    Environmental Science and Technology, 1972

    1972-01-01

    Recent reorganization of the General Accounting Office is reviewed. With regard to environmental concerns it is aiming to see if federal environmental programs are meeting the congressionally mandated objectives of laws. Surveys and reviews are explained. (BL)

  17. Perceived coping & concern predict terrorism preparedness in Australia

    Directory of Open Access Journals (Sweden)

    Stevens Garry

    2012-12-01

    Full Text Available Abstract Background In the aftermath of major terrorist incidents research shows population shifts towards protective behaviours, including specific preparedness and avoidance responses. Less is known about individual preparedness in populations with high assumed threat but limited direct exposure, such as Australia. In this study we aimed to determine whether individuals with high perceived coping and higher concern would show greater preparedness to respond to terrorism threats. Methods Adults in New South Wales (NSW completed terrorism perception and response questions as part of computer assisted telephone interviews (CATI in 2010 (N=2038. Responses were weighted against the NSW population. Multiple logistic regression analyses were conducted to evaluate the relationship between personal coping/concern factors and terrorism-related preparedness and avoidance behaviours, and to control for potential confounders such as socio-demographic and threat perception factors. Results Increased vigilance for suspicious behaviours was the most commonly reported behavioural response to perceived terrorism threat. Multivariate analyses showed that the factor combination of high perceived coping and higher concern was the most consistent predictor of terrorism preparedness behaviours and evacuation intentions, including increased vigilance (Adjusted Odd Ratios (AOR=2.07, p=0.001 learning evacuation plans (AOR=1.61, p=0.05, establishing emergency contact plans (AOR=2.73, p Conclusion The findings of this study suggest that terrorism preparedness behaviours are strongly associated with perceived high coping but that this relationship is also mediated by personal concerns relating to this threat. Cognitive variables such as coping self-efficacy are increasingly targeted as part of natural hazard preparedness and are a viable intervention target for terrorism preparedness initiatives. Raising individual coping perceptions may promote greater general and

  18. Specification of Concurrent Objects

    DEFF Research Database (Denmark)

    Sørensen, Morten U.

    imperative programs as well as externally by formulas in an interval logic, and even in a combination of the two styles.Verification among the different specification styles is illustrated by a number of experiments using a small distributed data base as a common example. Also, experiments are made...

  19. Hopes and fears of teacher candidates concerning the teaching profession

    Directory of Open Access Journals (Sweden)

    Creţu Daniela

    2017-01-01

    Full Text Available Romanian university students have the opportunity to enroll in the education program for the teaching profession starting with their first year at the university. Most undergraduates choose the education program for the teaching profession, although some of them do not see themselves as teachers. The schooling experiences, the motivation for entering the teacher education programs, the initial teacher education experiences and their future plans can be important factors in considering the perspective of becoming a teacher or not. Focused on a future orientation, the goal of this study was to investigate teacher education candidates’ hopes and fears concerning a possible career as teacher. Using an open-ended questionnaire as a research tool, a qualitative analysis was made on the hopes and fears expressed by the teacher candidates. Our findings showed different categories of hopes and fears and generated an enriched understanding of teacher candidates’ views on this subject. The study can be a valuable support for teacher educators preoccupied to understand teacher candidates’ perceptions and to assist them in getting closer to their ideals by improving the education program.

  20. NASA's Technology Utilization Program.

    Science.gov (United States)

    Farley, C. F.

    1972-01-01

    NASA's Technology Utilization Program is described, illustrating how it can be useful in achieving improved productivity, providing more jobs, solving public sector challenges, and strengthening the international competitive situation. Underlying the program is the fact that research and development conducted in NASA's aeronautics and space programs have generated much technical information concerning processes, products, or techniques which may be useful to engineers, doctors, or to others. The program is based on acquisition and publication, working with the user, and applications engineering.

  1. Childhood obesity policies - mighty concerns, meek reactions

    DEFF Research Database (Denmark)

    Vallgårda, Signild

    2017-01-01

    Background: The increasing number of children defined as overweight or obeseis causing concern among politicians and health advocates; several countries havelaunched policies addressing the issue.Method: The paper presents an analysis of how the childhood obesity is defined,explained and suggested...... policies to address the problem from the WHO, the EU,Canada, England and New Zealand.Results: Considering the dramatic language used when describing childhood obe-sity, the proposed interventions are modest. Either the politicians do not considerthe problem that great after all, or other concerns...... by evidence, and the evidence cited is sometimesmisinterpreted or disregarded.Conclusion: There is a discrepancy between how the problem of childhood obe-sity is presented as alarming and the modest measures suggested.Keywords: Childhood obesity, evidence, policies, responsibility....

  2. Body Image and Body Dysmorphic Concerns.

    Science.gov (United States)

    Tomas-Aragones, Lucia; Marron, Servando E

    2016-08-23

    Most people would like to change something about their bodies and the way that they look, but for some it becomes an obsession. A healthy skin plays an important role in a person's physical and mental wellbeing, whereas a disfiguring appearance is associated with body image concerns. Skin diseases such as acne, psoriasis and vitiligo produce cosmetic disfigurement and patients suffering these and other visible skin conditions have an increased risk of depression, anxiety, feelings of stigmatization and self-harm ideation. Body image affects our emotions, thoughts, and behaviours in everyday life, but, above all, it influences our relationships. Furthermore, it has the potential to influence our quality of life. Promotion of positive body image is highly recommended, as it is important in improving people's quality of life, physical health, and health-related behaviors. Dermatologists have a key role in identifying body image concerns and offering patients possible treatment options.

  3. Childhood obesity policies - mighty concerns, meek reactions

    DEFF Research Database (Denmark)

    Vallgårda, Signild

    2018-01-01

    Background: The increasing number of children defined as overweight or obeseis causing concern among politicians and health advocates; several countries havelaunched policies addressing the issue.Method: The paper presents an analysis of how the childhood obesity is defined,explained and suggested...... policies to address the problem from the WHO, the EU,Canada, England and New Zealand.Results: Considering the dramatic language used when describing childhood obe-sity, the proposed interventions are modest. Either the politicians do not considerthe problem that great after all, or other concerns...... by evidence, and the evidence cited is sometimesmisinterpreted or disregarded.Conclusion: There is a discrepancy between how the problem of childhood obe-sity is presented as alarming and the modest measures suggested....

  4. POSITIONINGS AND DELIMITATIONS CONCERNING THE PERFORMANCE AUDIT

    Directory of Open Access Journals (Sweden)

    Victoria FIRESCU

    2014-12-01

    Full Text Available The objectives of the present research are related to the approaches concerning the “performance audit” concept in the specialized literature and practice as well as the clear delimitation of this concept of financial audit and internal audit. For a clear emphasis of the objectives and principles of the performance audit, I highlighted the similarities and differences among the three types of audit by means of several criteria such as: audit standards, audited subjects, nature of the audit evidence, manners of assessment. Within this basically predominant research, I used several research methods and techniques such as: the critical analysis of the bibliographic sources concerning the performance audit, the documentation related to the international audit standards, comparative studies.

  5. Career Concern and Tax Preparer Fraud

    OpenAIRE

    Chao Yang; Liansheng Wu; Xianhui Bo

    2010-01-01

    This paper focuses on the effects of career concern on fraud among tax return preparers. A two-stage model is built to ascertain whether the propensity of tax preparers to cooperate with taxpayers in underpaying tax can be decreased if the revealed fraud behavior increases the probability of being audited by the tax agency in the following period. After solving the unique SPNE, this effect is shown to exist.

  6. Overconfidence in a Career-Concerns Setting

    DEFF Research Database (Denmark)

    de la Rosa, Leonidas Enrique

    2008-01-01

    We study the effects of overconfidence in a two-period investment-decision agency setting. Under common priors, agent risk aversion implies inefficiently low first-period investment. In our model, principal and agent disagree about the profitability of the investment decision conditional on a given...... the agent’s career concerns, even though an overconfident agent bears more project and reputational risk in equilibrium....

  7. Environmental Concerns, Environmental Policy and Green Investment.

    Science.gov (United States)

    Gao, Xuexian; Zheng, Haidong

    2017-12-13

    Environmental regulators often use environmental policy to induce green investment by firms. However, if an environmental policy fails to exert a long-run effect on regulating the economic agents' behavior, it may be more reasonable to think of the firm as the leader in the game, since the investment in green technology is usually a strategic decision. In this paper, we consider a three-stage Stackelberg game to address the interaction between a profit-maximizing firm (Stackelberg leader) facing emission-dependent demand, and the environmental regulator (Stackelberg follower). The firm decides on the green technology level in the first stage of the game based on its understanding of the regulator's profits function, especially an environmental concern that is introduced as an exogenous variable. In the current research, we show that high levels of the regulator's environmental concerns do not necessarily lead to the choice of green technology by the firm, and green investment level depends on the combined effects of the market and operational factors for a given level of the regulator's environmental concerns. The result also shows that increasing environmental awareness amongst the consumers is an effective way to drive the firm's green investment.

  8. Environmental Concerns, Environmental Policy and Green Investment

    Directory of Open Access Journals (Sweden)

    Xuexian Gao

    2017-12-01

    Full Text Available Environmental regulators often use environmental policy to induce green investment by firms. However, if an environmental policy fails to exert a long-run effect on regulating the economic agents’ behavior, it may be more reasonable to think of the firm as the leader in the game, since the investment in green technology is usually a strategic decision. In this paper, we consider a three-stage Stackelberg game to address the interaction between a profit-maximizing firm (Stackelberg leader facing emission-dependent demand, and the environmental regulator (Stackelberg follower. The firm decides on the green technology level in the first stage of the game based on its understanding of the regulator’s profits function, especially an environmental concern that is introduced as an exogenous variable. In the current research, we show that high levels of the regulator’s environmental concerns do not necessarily lead to the choice of green technology by the firm, and green investment level depends on the combined effects of the market and operational factors for a given level of the regulator’s environmental concerns. The result also shows that increasing environmental awareness amongst the consumers is an effective way to drive the firm’s green investment.

  9. Concerns about numeracy skills of nursing students.

    Science.gov (United States)

    Jukes, Lisa; Gilchrist, Mollie

    2006-07-01

    Accurate mathematical calculation is a critical skill that nurses must demonstrate in order to administer medications safely. The ability of undergraduate nurses to calculate the correct dosage of medication consistently has been a concern of schools of nursing for a long time. This study explores the ability of a group of nursing students to calculate mathematical drug problems within an English University. A convenience sample of 37 second year nursing students volunteered to complete a 10-item drug calculation test, requiring understanding of simple division and multiplication, percentages, ratio and proportion, conversion of units and multiple-stage procedures. The students' median correct score was 6 out of 10 (range 0-9). No one achieved full marks. Only 3 were able to achieve 9 out of 10, indicating that, on average, students were unable to achieve 90% mastery. This finding supports past literature and is of concern. It is of concern that these student nurses did not have the ability to perform drug calculations at a 90% mastery level. It has been recommended that admission requirements be reviewed, and that students are tested throughout their programme and that skills are reinforced both in the classroom and practice setting. This could be achieved using a variety of methods, supporting a teaching and learning framework to integrate analytical and procedural competence underpinned by the creation of national standards. Also, both educators and practitioners must take responsibility for ensuring adequate support and guidance are available to student nurses.

  10. From theory to practice concerning air quality monitoring

    Science.gov (United States)

    Ionel, Ioana; Makra, László; Bisorca, Daniel; Calinoiu, Delia Gabriela; Balogh, Ramon-Mihai

    2017-01-01

    The paper focuses on air quality monitoring campaigns in the city of Timisoara, in Romania. The measurements occurred during representative episodes, in the Northern and Southern part of the city, and the results were concluded in graphs and figures, raising special concern about the pollution with particles. The applied methods were standard, achieved by an accredited mobile laboratory (www.mediu.ro), as required by ISO 17025, and refer to the species: PM10, NOx, SO2, VOC, ozone, and CO. Finally proposals for improving the levels of concentrations were indicated, in accordance to the state of art and specificity of the city.

  11. Specifying Specification.

    Science.gov (United States)

    Paulo, Norbert

    2016-03-01

    This paper tackles the accusation that applied ethics is no serious academic enterprise because it lacks theoretical bracing. It does so in two steps. In the first step I introduce and discuss a highly acclaimed method to guarantee stability in ethical theories: Henry Richardson's specification. The discussion shows how seriously ethicists take the stability of the connection between the foundational parts of their theories and their further development as well as their "application" to particular problems or cases. A detailed scrutiny of specification leads to the second step, where I use insights from legal theory to inform the debate around stability from that point of view. This view reveals some of specification's limitations. I suggest that, once specification is sufficiently specified, it appears astonishingly similar to deduction as used in legal theory. Legal theory also provides valuable insight into the functional range of deduction and its relation to other forms of reasoning. This leads to a richer understanding of stability in normative theories and to a smart division of labor between deduction and other forms of reasoning. The comparison to legal theory thereby provides a framework for how different methods such as specification, deduction, balancing, and analogy relate to one another.

  12. Specific Dyslexia.

    Science.gov (United States)

    Naidoo, Sandhya

    The investigation reported in this volume attempts to clarify some issues relating to the existence, nature, and causes of specific dyslexia. Based on an extended study of 98 boys of at least average intelligence with severe reading and spelling problems, the report provides detailed data relating to their developmental and perinatal histories,…

  13. The Domain-Specific Software Architecture Program

    Science.gov (United States)

    1992-06-01

    SEI-92-SR-9 49 Lke Eit imist Eroaa Zoab DAwtant= I recommend the following: CF Rating: 03 Embedded- cpu .3; 80386 ; 33 MHz 95 03 Embedded- cpu -6; 80386 ; 25... cpu -I Type: 80286 Speed: 20 MHz Memory: 8 Mb SWassignments: chief-of-section-DSS, ballistics, Ave. utilization: 92% Bus assignment: Main-bus Physical...Implementation: physlcal- cpu -14 Me&sage*: Select Advice for advice oan ahemate processove Figure 6-10 Script for Fix Shows Existing Processor Eft bit

  14. Job Skills Education Program. Design Specifications

    Science.gov (United States)

    1985-03-01

    second or less. Keyboard The keyboard shall be a full size "typewriter" style, QWERTY or DVORAK arrangement and will contain keys associated with a...include telling time on both types of clocks. Responses can be with numbers from the keyboard and with touch panel or light pen. Error responses should...touch titles and code numbers on the correct document. The computer was selected for its response modes (both touch or light pen) and keyboard

  15. Memory Loss, Alzheimer's Disease and General Anesthesia: A Preoperative Concern.

    Science.gov (United States)

    Thaler, Adam; Siry, Read; Cai, Lufan; García, Paul S; Chen, Linda; Liu, Renyu

    2012-02-20

    The long-term cognitive effects of general anesthesia are under intense scrutiny. Here we present 5 cases from 2 academic institutions to analyze some common features where the patient's or the patient family member has made a request to address their concern on memory loss, Alzheimer's disease and general anesthesia before surgery. Records of anesthesia consultation separate from standard preoperative evaluation were retrieved to identify consultations related to memory loss and Alzheimer's disease from the patient and/or patient family members. The identified cases were extensively reviewed for features in common. We used Google® (http://www. google.com/) to identify available online information using "anesthesia memory loss" as a search phrase. Five cases were collected as a specific preoperative consultation related to memory loss, Alzheimer's disease and general anesthesia from two institutions. All of the individuals either had perceived memory impairment after a prior surgical procedure with general anesthesia or had a family member with Alzheimer's disease. They all accessed public media sources to find articles related to anesthesia and memory loss. On May 2 nd , 2011, searching "anesthesia memory loss" in Google yielded 764,000 hits. Only 3 of the 50 Google top hits were from peer-reviewed journals. Some of the lay media postings made a causal association between general anesthesia and memory loss and/or Alzheimer's disease without conclusive scientific literature support. The potential link between memory loss and Alzheimer's disease with general anesthesia is an important preoperative concern from patients and their family members. This concern arises from individuals who have had history of cognitive impairment or have had a family member with Alzheimer disease and have tried to obtain information from public media. Proper preoperative consultation with the awareness of the lay literature can be useful in reducing patient and patient family member

  16. Pet Food Safety A Shared Concern

    Energy Technology Data Exchange (ETDEWEB)

    Buchanan, Robert L [University of Maryland; Baker, Robert C [Mars, Inc.; Charlton, Adrian J [UK Food and Environmental Research Agency, Sand Hutton, York, UK; Riviere, Jim E [North Carolina State University; Standaert, Robert F [ORNL

    2011-01-01

    The safety of the food supply is a subject of intense interest to consumers, particularly as a result of large scale outbreaks that involve hundreds and sometimes thousands of consumers. During the last decade this concern about food safety has expanded to include the diets of companion animals as a result of several incidences of chemical toxicities and infectious disease transmission. This has led to increased research into the causes and controls for these hazards for both companion animals and their owners. The following summary provides an introduction to the issues, challenges, and new tools being developed to ensure that commercial pet foods are both nutritious and safe.

  17. Pet food safety: a shared concern.

    Science.gov (United States)

    Buchanan, Robert L; Baker, Robert C; Charlton, Adrian J; Riviere, Jim E; Standaert, Robert

    2011-10-01

    The safety of the food supply is a subject of intense interest to consumers, particularly as a result of large-scale outbreaks that involve hundreds and sometimes thousands of consumers. During the last decade, this concern about food safety has expanded to include the diets of companion animals as a result of several incidences of chemical toxicities and infectious disease transmission. This has led to increased research into the causes and controls for these hazards for both companion animals and their owners. The following summary provides an introduction to the issues, challenges and new tools being developed to ensure that commercial pet foods are both nutritious and safe.

  18. Composite Overwrap Fragmentation Observations, Concerns, and Recommendations

    Science.gov (United States)

    Bangham, Mike; Hovater, Mary

    2017-01-01

    A series of test activities has raised some concerns about the generation of orbital debris caused by failures of composite overwrapped pressure vessels (COPVs). These tests have indicated that a large number of composite fragments can be produced by either pressure burst failures or by high-speed impacts. A review of prior high-speed tests with COPV indicates that other tests have produced large numbers of composite fragments. As was the case with the test referenced here, the tests tended to produce a large number of small composite fragments with relatively low velocities induced by the impact and or gas expansion.

  19. Issues and Concerns in Special Education Microcomputing.

    Science.gov (United States)

    Maddux, Cleborne D.

    1986-01-01

    Discussion of microcomputer use in public elementary schools focuses on the field of special education. Two main ways of using computers are described: (1) traditional uses, including administration, computer-assisted instruction, and assessment; and (2) new applications, including programming, word processing, simulations, and prosthetic aids…

  20. Understanding Trainees' Perception Concerning the Educational ...

    African Journals Online (AJOL)

    Background: Trainees' skills and the teaching process can be improved by consideration of candidates' views. Aim: To find out the trainees' perception and views about the features and teaching methods of the Family Practice Training Program (FPSTP) in Kuwait to upgrade its standard. Methods: The study design is cross ...

  1. Sex and Prevention Concerns for Positive People

    Science.gov (United States)

    ... care & treatment HIV cure advocacy HIV policy HIV prevention CONTRIBUTORS Project Inform Twitter Feed Project Inform ProjectInform ProjectInform #HARMREDnews : This needle exchange program fights the stigma of addiction. https://t.co/B5LJHD0YAO 3 days . reply . retweet . ...

  2. Fetal Alcohol Syndrome: An International Concern.

    Science.gov (United States)

    Asetoyer, Charon

    1987-01-01

    Describes Fetal Alcohol Effects (FAE) and Fetal Alcohol Syndrome (FAS) in infants, caused by mothers' consumption of alcohol during pregnancy. Both disabilities found in relatively high proportions of American Indian children. Discusses impact of disabilities on education. Discusses parent education programs in United States and abroad. (TES)

  3. A Survey of Associate of Arts and Associate of Science Degree Programs in 13 Western States.

    Science.gov (United States)

    Bekker, Gerald

    The Associate of Arts and Associate of Science degree programs offered by selected colleges and universities in 13 western states were examined to determine relevant information regarding the composition of the degrees offered. The study specifically concerned: the purpose of the degree, the title assigned to the degree, the length of time…

  4. Death concerns and psychological well-being in mothers of children with autism spectrum disorder.

    Science.gov (United States)

    Cox, Cathy R; Eaton, Sara; Ekas, Naomi V; Van Enkevort, Erin A

    2015-01-01

    Utilizing a terror management theory perspective, the present research examined whether having a child with autism spectrum disorder (ASD) is associated with underlying cognitions and explicit worries about death, and their roles in psychological well-being. 147 mothers of children with ASD (n=74) and typically developing children (n=73) completed a fear of death scale, as well as measures of death-thought accessibility, positive and negative affect, depression, and anxiety. Following previous research, mothers of children with ASD reported worse psychological health. Additionally, they evidenced greater death-thought accessibility compared to mothers of typically developing children, but did not differ in explicit worries about mortality. Greater death-thought accessibility, in turn, mediated the influence of ASD diagnosis on negative affect, depression, and anxiety. The current study offers an initial understanding of the association between mortality concerns and psychological health for mothers of children with ASD. Further, it underscores the importance of health care providers' efforts to attend to, and educate parents about, their thoughts of mortality, even if the parent does not acknowledge such concerns. The present study examined the impact of both implicit and explicit worries about death in parents of children with Autism Spectrum Disorder (ASD). Specifically, we were able to demonstrate that increased death-thought accessibility among mothers of children with ASD was associated with worse psychological health. While it is possible for parents of children with ASD to report conscious worries about death, there were no observed differences on this measure. As far as we know, this work is the first to empirically examine the prevalence of mortality-related concerns in this population and the subsequent effects of death-thought accessibility on psychological health. This is an important avenue of research as parents of children with ASD may experience

  5. Parental concerns in children requiring palliative care

    Directory of Open Access Journals (Sweden)

    Manjiri Dighe

    2008-01-01

    Full Text Available Children with advanced, life-limiting illness have unique needs which are different from those of adults. Pediatric palliative care is an under developed specialty. Aims : To identify concerns of parents of children with advanced, incurable cancers, and to elicit their attitudes toward revealing the diagnosis and prognosis to the sick child. Method : This study was carried out in a large tertiary cancer center in India. Parents of 20 pediatric palliative care patients attending the outpatient department were interviewed and emerging themes identified. Results : Parents showed varying degrees of anticipatory grief. Most families were financially strained. Most parents were reluctant to discuss disease and dying with the child. Siblings were rarely told or directly involved in care. There was resistance to allowing the palliative care team to communicate with the patient. Patients did not receive any formal support. Parents identified family and neighbors as the main sources of support. Conclusions : Parental attitudes hinder open communication with dying children in India. There is a need for research to explore the concerns of families of children with fatal illness. Specialist training is required for professionals working in pediatric palliative care to address this issue.

  6. Body image concern among Australian adolescent girls: the role of body comparisons with models and peers.

    Science.gov (United States)

    Carey, Renee N; Donaghue, Ngaire; Broderick, Pia

    2014-01-01

    This study investigated the potential mediating roles of body comparisons with peers and models in the relationship between the internalization of thinness norms and body image concern. A total of 224 Western Australian girls aged 14-15 completed questionnaires assessing their endorsement of thinness norms, body image concerns, and frequency of body comparisons with peers and with models. Both targets of body comparisons were found to significantly mediate the relationship between the endorsement of thinness norms and body image concern, with body comparison with peers a stronger mediator than comparison with models. These findings show that body comparison with peers, in particular, plays a significant role in the experience of body image concerns among adolescent girls, and should be given a higher profile in programs designed to prevent or reduce body image concern. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Lidar base specification

    Science.gov (United States)

    Heidemann, Hans Karl

    2012-01-01

    In late 2009, a $14.3 million allocation from the “American Recovery and Reinvestment Act” for new light detection and ranging (lidar) elevation data prompted the U.S. Geological Survey (USGS) National Geospatial Program (NGP) to develop a common base specification for all lidar data acquired for The National Map. Released as a draft in 2010 and formally published in 2012, the USGS–NGP “Lidar Base Specification Version 1.0” (now Lidar Base Specification) was quickly embraced as the foundation for numerous state, county, and foreign country lidar specifications. Prompted by a growing appreciation for the wide applicability and inherent value of lidar, a USGS-led consortium of Federal agencies commissioned a National Enhanced Elevation Assessment (NEEA) study in 2010 to quantify the costs and benefits of a national lidar program. A 2012 NEEA report documented a substantial return on such an investment, defined five Quality Levels (QL) for elevation data, and recommended an 8-year collection cycle of Quality Level 2 (QL2) lidar data as the optimum balance of benefit and affordability. In response to the study, the USGS–NGP established the 3D Elevation Program (3DEP) in 2013 as the interagency vehicle through which the NEEA recommendations could be realized. Lidar is a fast evolving technology, and much has changed in the industry since the final draft of the “Lidar Base Specification Version 1.0” was written. Lidar data have improved in accuracy and spatial resolution, geospatial accuracy standards have been revised by the American Society for Photogrammetry and Remote Sensing (ASPRS), industry standard file formats have been expanded, additional applications for lidar have become accepted, and the need for interoperable data across collections has been realized. This revision to the “Lidar Base Specification Version 1.0” publication addresses those changes and provides continued guidance towards a nationally consistent lidar dataset.

  8. Body Image concerns of Male Rugby Players, with specific focus on Muscularity and Body Fat

    OpenAIRE

    Mills, Claire D; Giles, G J

    2017-01-01

    Introduction: Despite the high numbers of participants in both rugby league and union, literature on body image of male rugby players is somewhat limited. However researchers have theorized that the exercise adopted by males may reflect different levels of dissatisfaction, especially in activities that require a large body build, or lean aesthetic physique [1]. Therefore, this study aimed to explore the prevalence of body (dis)satisfaction in terms of muscularity and body fat, and secondly to...

  9. ADHD and Female Specific Concerns: A Review of the Literature and Clinical Implications

    Science.gov (United States)

    Nussbaum, Nancy L.

    2012-01-01

    ADHD was once thought of as a predominantly male disorder. While this may be true for ADHD in childhood, extant research suggests that the number of women with ADHD may be nearly equal to that of men with the disorder (Faraone et al., 2000). There is accumulating research which clearly indicates subtle but important sex differences exist in the…

  10. [Multilingualism and specific language impairment].

    Science.gov (United States)

    Arkkila, Eva; Smolander, Sini; Laasonen, Marja

    2013-01-01

    Specific language impairment is one of the most common developmental disturbances in childhood. With the increase of the foreign language population group an increasing number of children assimilating several languages and causing concern in language development attend clinical examinations. Knowledge of factors underlying the specific language impairment and the specific impairment in general, special features of language development of those learning several languages, as well as the assessment and support of the linguistic skills of a multilingual child is essential. The risk of long-term problems and marginalization is high for children having specific language impairment.

  11. Aspects Concerning the Relationship between Internal Audit and Fraud Risk

    Directory of Open Access Journals (Sweden)

    Ioana Lupasc

    2016-07-01

    Full Text Available In the current economical situation, fraud cannot be regarded as an exception with random occurrence and limited effects on credit institution. Major fraud scandals that shook the financial markets required a rethinking of the organization and control of the banks to keep intact the trust of customers. Identifying and assessing risks is a concern not only for managers, but also for internal and external auditors. Management may implement programs or measures to limit the risks or deciding to accept some risks. In order to identify the main causes generating fraud risk and increasing the quality of banking activity we used a quantitative research method that was based on a questionnaire administered individually, using SPSS.

  12. Using Cost-Effectiveness Analysis to Address Health Equity Concerns.

    Science.gov (United States)

    Cookson, Richard; Mirelman, Andrew J; Griffin, Susan; Asaria, Miqdad; Dawkins, Bryony; Norheim, Ole Frithjof; Verguet, Stéphane; J Culyer, Anthony

    2017-02-01

    This articles serves as a guide to using cost-effectiveness analysis (CEA) to address health equity concerns. We first introduce the "equity impact plane," a tool for considering trade-offs between improving total health-the objective underpinning conventional CEA-and equity objectives, such as reducing social inequality in health or prioritizing the severely ill. Improving total health may clash with reducing social inequality in health, for example, when effective delivery of services to disadvantaged communities requires additional costs. Who gains and who loses from a cost-increasing health program depends on differences among people in terms of health risks, uptake, quality, adherence, capacity to benefit, and-crucially-who bears the opportunity costs of diverting scarce resources from other uses. We describe two main ways of using CEA to address health equity concerns: 1) equity impact analysis, which quantifies the distribution of costs and effects by equity-relevant variables, such as socioeconomic status, location, ethnicity, sex, and severity of illness; and 2) equity trade-off analysis, which quantifies trade-offs between improving total health and other equity objectives. One way to analyze equity trade-offs is to count the cost of fairer but less cost-effective options in terms of health forgone. Another method is to explore how much concern for equity is required to choose fairer but less cost-effective options using equity weights or parameters. We hope this article will help the health technology assessment community navigate the practical options now available for conducting equity-informative CEA that gives policymakers a better understanding of equity impacts and trade-offs. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  13. European contribution to heat exchanger design/performance: HTFS research and computer programs. Final report. [SCON4 and CEMP1

    Energy Technology Data Exchange (ETDEWEB)

    Lang, C.; Skrovanek, T.

    1979-01-01

    The performance of selected HTFS computer program in solving example heat exchanger design/performance situations is evaluated. In addition, the specific inputs required by the program are presented to give an idea of the amount of detail the user must supply concerning the heat transfer system. Comments on the versatility of each program and technical details necessary for running each program are also provided. The computer programs examined rate the performance of shell-and-tube type condensers and plate-fin heat exchangers.

  14. Research and Evaluation in Teacher Education: A Concern for Competent, Effective Teachers.

    Science.gov (United States)

    Dickson, George E.; Wiersma, William

    The College of Education of the University of Toledo designed a competency-based teacher education (CBTE) program in 1968-69 and began the implementation of that program in 1970. The total CBTE program is based upon a predetermined set of specific behaviors to be mastered, and includes a Teacher Education Center as a coordinating, materials and…

  15. Body weight concerns and antifat attitude in iranian children

    Directory of Open Access Journals (Sweden)

    Saideh Garousi

    2014-01-01

    Full Text Available Background: There is increasing evidence that children are showing body image issues in recent years. Body image disturbances in childhood must be taken seriously. The thin ideal is becoming more prominent in Asian countries; however, there is little research examining how this issue affects Iranian children. This study explores body weight concerns and associated factors among children in Iranian elementary schools. Methods: This study was conducted in 500 elementary schools. An assessment of body image and antifat attitudes was undertaken using the figure rating scale. In addition, body mass index (BMI and demographic variables were assessed. Results: Nearly, 27.4% of children were underweight, and 13.3% were obese. There was a significant difference between the mean score of body dissatisfaction (BD between boys and girls (P < 0.05. There were no differences between BD and education of parents, age, and academic grades. In girls, antifat attitudes were significantly related to BMI. Conclusions: The results of this study demonstrate the paramount importance of undertaking further research in order to identify the predictive factors of body concerns and its consequences among Iranian children. In addition, researchers must plan prevention and educational program for these children.

  16. Canadian pediatric gastroenterology workforce: Current status, concerns and future projections

    Science.gov (United States)

    Morinville, Véronique; Drouin, Éric; Lévesque, Dominique; Espinosa, Victor M; Jacobson, Kevan

    2007-01-01

    BACKGROUND: There is concern that the Canadian pediatric gastroenterology workforce is inadequate to meet health care demands of the pediatric population. The Canadian Association of Gastroenterology Pediatric Committee performed a survey to determine characteristics and future plans of the Canadian pediatric gastroenterology workforce and trainees. METHODS: Estimates of total and pediatric populations were obtained from the 2001 Census of Population, Statistics Canada (with estimates to July 1, 2005). Data on Canadian pediatric gastroenterologists, including clinical full-time equivalents, sex, work interests, opinions on workforce adequacy, retirement plans, fellowship training programs and future employment plans of fellows, were gathered through e-mail surveys and telephone correspondence in 2005 and 2006. RESULTS: Canada had an estimated population of 32,270,507 in 2005 (6,967,853 people aged zero to 17 years). The pediatric gastroenterology workforce was estimated at 9.2 specialists per million children. Women accounted for 50% of the workforce. Physician to pediatric population ratios varied, with Alberta demonstrating the highest and Saskatchewan the lowest ratios (1:69,404 versus 1:240,950, respectively). Between 1998 and 2005, Canadian pediatric gastroenterology fellowship programs trained 65 fellows (65% international trainees). Twenty-two fellows (34%) entered the Canadian workforce. CONCLUSIONS: The survey highlights the variable and overall low numbers of pediatric gastroenterologists across Canada, an increasingly female workforce, a greater percentage of part-time physicians and a small cohort of Canadian trainees. In conjunction with high projected retirement rates, greater demands on the work-force and desires to partake in nonclinical activities, there is concern for an increasing shortage of pediatric gastroenterologists in Canada in future years. PMID:17948136

  17. Comparative Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one. In the comp....... In the comparative approach the outcomes of different software tools are compared, while in the empirical approach the modelling results are compared with the results of experimental test cases. The comparative test cases include: ventilation, shading and geometry....

  18. Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one. I....... In the comparative approach the outcomes of different software tools are compared, while in the empirical approach the modelling results are compared with the results of experimental test cases....

  19. Fundamental studies concerning planetary quarantine in space.

    Science.gov (United States)

    Koike, J; Hori, T; Katahira, Y; Koike, K A; Tanaka, K; Kobayashi, K; Kawasaki, Y

    1996-01-01

    If there is a possibility that the organisms carried from Earth to space can live for a significant period on planets, the contamination of planets should be prevented for the purpose of future life-detection experiments. In connection with quarantine for interplanetary missions, we have examined the survivabilities of terrestrial microorganisms under simulated space conditions. In this study, examined the survivabilities of terrestrial organisms under simulated Mars conditions. The Mars conditions were simulated by ultraviolet (UV) and proton irradiation under low temperature, high vacuum, and simulated gaseous conditions. After exposure to the simulated Mars condition, the survivabilities of the organisms were examined. The spores of Bacillus subtilis and Aspergillus niger, some anaerobic bacterias and algaes, showed considerably high survivabilities even after UV and proton irradiation corresponding to 200 years on Mars. This subject is not restricted to academic curiosity but concerns problems involving the contamination of Mars with terrestrial organisms carried by space-probes.

  20. Pregnancy after renal transplantation: prospects and concerns.

    Science.gov (United States)

    Khedmat, Hossein; Alavian, Seyed Moayed; Taheri, Saeed

    2009-01-01

    The first child born to a renal transplant patient who was the first woman undergone a renal transplant from her identical twin celebrated his 53th birthday on March 10, 2009. Since this first experience, over 14,000 births among women with transplanted organs have been reported worldwide and several more also not reported. Pregnancy is now considered a frequent part of women after organ transplantation. However, substantial gaps remain in our knowledge about pregnancy in the transplant recipient and its effects on the mother and child. As well, several ethical concerns have been raised about the wisdom of pregnancy for a woman with a proportionally lower life span with expected medical complications. In this review article we tried to address all issues related to pregnancy after renal transplantation.