WorldWideScience

Sample records for program announcements pas

  1. 75 FR 16072 - Fisheries Finance Program; Final Program Notice and Announcement of Availability of Federal...

    Science.gov (United States)

    2010-03-31

    .... Aquacultural facilities construction, reconstruction, reconditioning, and acquisition 2. Fisheries shoreside... National Oceanic and Atmospheric Administration RIN 0648-XV46 Fisheries Finance Program; Final Program Notice and Announcement of Availability of Federal Financial Assistance AGENCY: National Marine Fisheries...

  2. 77 FR 6113 - Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting

    Science.gov (United States)

    2012-02-07

    ... COMMISSION Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting... meeting of the Video Programming Accessibility Advisory Committee (``Committee'' or ``VPAAC''). The... description, access to emergency programming, and access to user interfaces, menus, and programming guides...

  3. 76 FR 57989 - Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting

    Science.gov (United States)

    2011-09-19

    ... COMMISSION Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting... meeting of the Video Programming Accessibility Advisory Committee (``Committee'' or ``VPAAC''). The..., and the delivery of video description, access to emergency programming, and the interoperability and...

  4. 76 FR 2686 - Video Programming and Emergency Access Advisory Committee; Announcement of Establishment and...

    Science.gov (United States)

    2011-01-14

    ... COMMISSION Video Programming and Emergency Access Advisory Committee; Announcement of Establishment and... Programming and Emergency Access Advisory Committee (``Committee'' or ``VPEAAC'') of the Federal... name to the Video Programming Accessibility Advisory Committee (``VPAAC''). The Commission further...

  5. 76 FR 19356 - Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting

    Science.gov (United States)

    2011-04-07

    ... COMMISSION Video Programming and Accessibility Advisory Committee; Announcement of Date of Next Meeting... meeting of the Video Programming Accessibility Advisory Committee (``Committee'' or ``VPAAC''). The meeting will address the provision of closed captioning of Internet programming previously captioned on...

  6. 77 FR 3269 - Loan Repayment Program for Repayment of Health Professions Educational Loans; Announcement Type...

    Science.gov (United States)

    2012-01-23

    ...] Loan Repayment Program for Repayment of Health Professions Educational Loans; Announcement Type... the IHS Loan Repayment Program (LRP) for health professional educational loans (undergraduate and..., nursing, public health nursing, dentistry, psychiatry, osteopathy, optometry, pharmacy, psychology, public...

  7. 77 FR 26245 - Household Water Well System Grant Program Announcement of Application Deadlines and Funding

    Science.gov (United States)

    2012-05-03

    ... with low to moderate incomes finance the costs of household water wells that they own or will own. The... Rural Utilities Service Household Water Well System Grant Program Announcement of Application Deadlines... in grant funds to be competitively awarded for the Household Water Well System (HWWS) Grant Program...

  8. Norway/United States Design Protective Aircraft Shelter (PAS) Quantity-Distance Program 1/3-Scale Test Series. Volume 3. Appendix B: PAS-3

    Science.gov (United States)

    1993-08-01

    38939 20350 50078 23.98 432 -2827 17753 20204 61.49 433 -2390 20698 22654 66.02 434 -3187 20337 22665 63.80 435 -1394 16189 18152 63.10 436 -278 17324...3232 15668 18614 57.32 443 32.4 -2677 9694 13569 45.59 444 35.5 -2231 9104 12836 45.18 435 41.4 -1394 16189 18152 63.10 436 43.2 -278 17324 18721 67.73...319.87 435 41.4 -1394 16189 18152 63.10 209 PAS- 3 CONCRETE DEBRIS COLLECTION SURVEY SORTED BY RANGE COORDINATES FROM GZ: I.D. MARK WEIGHT X Y RANGE

  9. 77 FR 10543 - Announcement of Funding Awards for the Capacity Building for Sustainable Communities Program for...

    Science.gov (United States)

    2012-02-22

    ... 2000, dba Envision 600,000 Utah, 254 South 600 East, Salt Lake City, UT Institute for Sustainable... URBAN DEVELOPMENT Announcement of Funding Awards for the Capacity Building for Sustainable Communities Program for Fiscal Year 2011 AGENCY: Office of Sustainable Housing and Communities, HUD. ACTION...

  10. 76 FR 66318 - Announcement of Funding Awards; Limited English Proficiency Initiative Program (LEPI), Fiscal...

    Science.gov (United States)

    2011-10-26

    ... URBAN DEVELOPMENT Announcement of Funding Awards; Limited English Proficiency Initiative Program (LEPI... funding under the Notice of Funding Availability (NOFA) for the Limited English Proficiency Initiative... INFORMATION: Executive Order 13166 signed in August 2000 requires all federal agencies to improve access to...

  11. 76 FR 68499 - Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement

    Science.gov (United States)

    2011-11-04

    ... and time. Water shortage and water-use conflicts have become more commonplace in many areas of the... Office of the Secretary Draft WaterSMART Cooperative Watershed Management Program Funding Opportunity Announcement AGENCY: Office of the Assistant Secretary for Water and Science, Interior. ACTION: Notice of...

  12. 76 FR 55084 - Announcement of Funding Awards for the Section 202 Supportive Housing for the Elderly Program...

    Science.gov (United States)

    2011-09-06

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Section 202 Supportive Housing for the Elderly... Availability (NOFA) for the Section 202 Supportive Housing for the Elderly Program. This announcement contains... Elderly Program is authorized by section 202 of the Housing Act of 1959 (12 U.S.C. 1701q), as amended by...

  13. 75 FR 62849 - Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program (SHOP) for...

    Science.gov (United States)

    2010-10-13

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program... Funding Availability (NOFA) for the Self-Help Homeownership Opportunity Program (SHOP). This announcement... nonprofit organizations and consortia that have experience in providing self-help housing. Grant funds are...

  14. 76 FR 67759 - Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program (SHOP) for...

    Science.gov (United States)

    2011-11-02

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program... Funding Availability (NOFA) for the Self-Help Homeownership Opportunity Program (SHOP). This announcement... organizations and consortia that have experience in providing self-help housing. Grant funds are used to...

  15. 77 FR 40892 - Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program (SHOP) for...

    Science.gov (United States)

    2012-07-11

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program... Funding Availability (NOFA) for the Self-Help Homeownership Opportunity Program (SHOP). This announcement... national and regional nonprofit organizations and consortia to undertake self-help homeownership housing...

  16. 76 FR 48876 - Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program (SHOP) for...

    Science.gov (United States)

    2011-08-09

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Self-Help Homeownership Opportunity Program... Funding Availability (NOFA) for the Self-Help Homeownership Opportunity Program (SHOP). This announcement... nonprofit organizations and consortia that have experience in providing self-help housing. Grant funds are...

  17. Ford Partnership for Advanced Studies (Ford PAS)

    Science.gov (United States)

    Carrier, Cheryl

    2006-01-01

    This article features the Ford Partnership for Advanced Studies (Ford PAS) program that helps students gain knowledge about real-life business issues. Ford PAS is an educational program that combines college-prep academics with the critical 21st century skills students will need to succeed in college and in the workplace. The Ford PAS program uses…

  18. 75 FR 21307 - Injury Prevention Program; Announcement Type: Cooperative Agreement

    Science.gov (United States)

    2010-04-23

    ...., pharmacy, physical therapy, dietitian, optometrist, etc); (2) an exercise program (senior centers, Health... will increase front seat passenger's safety belt use at Bob Cat Canyon community to 95% by January 2015... incentive programs (print, radio and video). The following costs are deemed unallowable costs--Equipment...

  19. Funding Opportunity Announcement: Pesticide Safety Education Funds Management Program

    Science.gov (United States)

    EPA is soliciting proposals from eligible applicants to establish and administer a national subaward program in support of pesticide applicator education and training for certified applicators of restricted use pesticides.

  20. FY 2016 Grant Announcement: FY 2016 Technical Analysis and Programmatic Evaluation Support to the Chesapeake Bay Program Partnership

    Science.gov (United States)

    The U.S. Environmental Protection Agency’s Chesapeake Bay Program Office is announcing a Request for Proposals for applicants to provide the Chesapeake Bay Program partners with a proposal(s) for providing technical analysis and programmatic evaluation

  1. 78 FR 56906 - Announcement of the Award of Three Single-Source Program Expansion Supplement Grants to National...

    Science.gov (United States)

    2013-09-16

    ... HUMAN SERVICES Administration for Children and Families Office of Refugee Resettlement Announcement of the Award of Three Single-Source Program Expansion Supplement Grants to National Human Trafficking... . SUPPLEMENTARY INFORMATION: The National Human Trafficking Victim Assistance Program (NHTVAP) provides funding...

  2. Effectiveness of a physical activity program on cardiovascular disease risk in adult primary health-care users: the "Pas-a-Pas" community intervention trial.

    Science.gov (United States)

    Arija, Victoria; Villalobos, Felipe; Pedret, Roser; Vinuesa, Angels; Timón, Mercé; Basora, Teresa; Aguas, Dolors; Basora, Josep

    2017-06-15

    Physical activity is a major, modifiable, risk factor for cardiovascular disease (CVD) that contributes to the prevention and management of CVD. The aim of this study was to assess the short- and medium-term effectiveness of 9 months of a supervised physical activity program, including sociocultural activities, on CVD risk in adults. Multicentered, randomized, controlled community intervention involving 364 patients in four primary care centers. The participants were randomly assigned to a Control Group (CG = 104) or Intervention Group (IG = 260); mean age 65.19 years; 76.8% women. The intervention consisted of 120 min/week walking (396 METs/min/week) and sociocultural gathering once a month. Clinical history, physical activity, dietary intake, CVD risk factors (smoking, systolic and diastolic blood pressure, weight, waist circumference, BMI, total cholesterol, LDL- and HDL-cholesterol, triglycerides, glycosylated hemoglobin and glucose) and global CVD risk were assessed at baseline and at the end of the intervention and multivariate models were applied to the data. Incidence of adverse cardiovascular events and continued adherence to the physical activity were assessed 2 years after intervention. At the end of the intervention period, in the IG relative to the CG group, there was a significant increase in physical activity (774.81 METs/min/week), a significant change during the intervention period in systolic blood pressure (-6.63 mmHg), total cholesterol (-10.12 mg/dL) and LDL-cholesterol (-9.05 mg/dL) even after adjustment for potential confounders. At 2 years after the intervention, in the IG, compared with the CG, tthe incidence of adverse cardiovascular events was significantly lower (2.5% vs. 10.5%) and the adherence to regular physical activity was higher (72.8% vs 27.2%) in IG compared to CG. This community-based physical activity program improved cardiovascular health in the short- as well as medium-term, and promoted regular physical activity

  3. Should we be worried about the green paradox? Announcement effects of the acid rain program

    Energy Technology Data Exchange (ETDEWEB)

    Di Maria, Corrado [Birmingham Univ. (United Kingdom); Lange, Ian [Stirling Univ. (United Kingdom); Werf, Edwin van der [Wageningen Univ. (Netherlands)

    2012-05-15

    This paper presents the first empirical test of the green paradox hypothesis, according to which well-intended but imperfectly implemented policies may lead to detrimental environmental outcomes due to supply side responses. We use the introduction of the Acid Rain Program in the U.S. as a case study. The theory predicts that owners of coal deposits, expecting future sales to decline, would supply more of their resource between the announcement of the Acid Rain Program and its implementation; moreover, the incentive to increase supply would be stronger for owners of high-sulfur coal. This would, all else equal, induce an increase in sulfur dioxide emissions. Using data on prices, heat input and sulfur content of coal delivered to U.S. power plants, we find strong evidence of a price decrease, some indication that the amount of coal used might have increased, and no evidence that the announcement of the Acid Rain Program lead the use of higher sulfur coal. Overall, our evidence suggests that while the mechanism indicated by the theory might be at work, market conditions and concurrent regulation prevented a green paradox from arising. These results have implications for the design of climate policies.

  4. 76 FR 59151 - Announcement of Funding Awards; HOPE VI Main Street Grant Program, Fiscal Year (FY) 2009

    Science.gov (United States)

    2011-09-23

    ... URBAN DEVELOPMENT Announcement of Funding Awards; HOPE VI Main Street Grant Program, Fiscal Year (FY..., Office of Public and Indian Housing, Department of Housing and Urban Development, 451 7th Street, SW..., 2009). The purpose of the HOPE VI Main Street program is to provide grants to small communities to...

  5. Complementary Public Service Announcements as a Strategy for Enhancing the Impact of Health-Promoting Messages in Fictional Television Programs.

    Science.gov (United States)

    Bavin, Lynda M; Owens, R Glynn

    2017-02-17

    Research suggests that health-promoting storylines in developed nations' fictional television programs can have a beneficial impact on viewers' beliefs, attitudes, intentions, or behaviors. The sizes of the effects are generally modest; however, the audience reach is substantial. Given that many fictional programs may hold the prolonged attention of millions of viewers, it is of value to examine potential strategies for enhancing the persuasive impact of their health-promoting storylines. Complementary public service announcements may be a promising strategy. This randomized experimental study (N = 310) examined the effects of viewing a complementary public service announcement after an organ donation story in an episode of Grey's Anatomy. Results indicated that the public service announcement enhanced the beneficial impact of the story on viewers' discussion behavior (about one's organ donor wishes), discussion intention, and perceived learning. This experimental study is the first to examine the effects of viewing a non-character public service announcement after a health-related storyline in a developed nation's fictional program compared to viewing the same episode of the program on its own. It is important for future research to examine whether these findings replicate for different health issues and with a nationally representative sample.

  6. 76 FR 67195 - Announcing the Award of a Single-Source Program Expansion Supplement Grant to the Johns Hopkins...

    Science.gov (United States)

    2011-10-31

    ... HUMAN SERVICES Administration for Children and Families Announcing the Award of a Single-Source Program... and Recovery Act of 2010 . SUMMARY: The Administration for Children and Families (ACF), Office of... technology architecture with ACF/Office of Information Services. The project will produce a solution that...

  7. 77 FR 19306 - Announcement of Funding Awards: Office of Healthy Homes and Lead Hazard Control Grant Programs...

    Science.gov (United States)

    2012-03-30

    ... URBAN DEVELOPMENT Announcement of Funding Awards: Office of Healthy Homes and Lead Hazard Control Grant Programs for Fiscal Year (FY) 2011 AGENCY: Office of Healthy Homes and Lead Hazard Control, HUD. ACTION... made by the Department in competitions for funding under the Office of Healthy Homes and Lead Hazard...

  8. 77 FR 5043 - Announcement of Funding Awards for the Brownfields Economic Development Initiative (BEDI) Program...

    Science.gov (United States)

    2012-02-01

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Brownfields Economic Development Initiative...) 2009 Notice of Funding Availability (NOFA) for the Brownfield Economic Development Initiative (BEDI... by HUD. FOR FURTHER INFORMATION CONTACT: David Kaminsky, Office of Economic Development Grants...

  9. 77 FR 5044 - Announcement of Funding Awards for the Brownfields Economic Development Initiative (BEDI) Program...

    Science.gov (United States)

    2012-02-01

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Brownfields Economic Development Initiative... (FLY) 2010 Notice of Funding Availability (NOFA) for the Brownfield Economic Development Initiative... available by HUD. FOR FURTHER INFORMATION CONTACT: David Kaminsky, Office of Economic Development Grants...

  10. EPA, the Mayor’s Office of Sustainability in Atlanta, Atlanta Workforce Development Agency and Local Partners Announce the Proctor Creek Trash Free Waters Community Workforce Program

    Science.gov (United States)

    EPA News Release: EPA, the Mayor’s Office of Sustainability in Atlanta, Atlanta Workforce Development Agency and Local Partners Announce the Proctor Creek Trash Free Waters Community Workforce Program

  11. News & Announcements

    Science.gov (United States)

    2000-01-01

    recipients in the 1999 fellowship programs. The names of those in chemistry or chemistry-related programs appear below. The complete list and background information about fellowship programs are available at http://national-academies.org. Information about the next (2000) competition can be obtained by contacting the Fellowship Office of the National Research Council, 2101 Constitution Avenue, NW, Washington, DC 20418; email: infofell@nas.edu; WWW: http://fellowships.nas.edu. 1999 Predoctoral Fellows Martin Elliott Hayes, Massachusetts Institute of Technology, Organic Chemistry 1999 Dissertation Fellows Robyn P. Hickerson, University of Utah, Chemistry 1999 Postdoctoral Fellows Luke Koenigs Lightning, University of California, San Francisco, Biochemistry Eric W. Wong, University of California, Los Angeles, Physical Chemistry University of Wisconsin System Award Alliant Energy has announced the recipient of its 1999 Underkofler Excellence in Teaching Award, to recognize and reward outstanding teachers at University of Wisconsin System institutions. Kim Kostka, University of Wisconsin-Rock County, Janesville, Wisconsin Kim is also the recipient of the 1999 Green Chemistry Challenge Award from the Environmental Protection Agency and the National Partnership for Reinventing Government. She is co-editor of the JCE feature column Teaching with Problems and Case Studies. Award Deadlines James Flack Norris Award The Northeastern Section of the American Chemical Society is receiving nominations for the 2000 James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry. The Norris Award, one of the oldest awards given by a Section of the American Chemical Society, is presented annually and consists of a certificate and an honorarium of 3,000. Nominees must have served with special distinction as teachers of chemistry at any level: secondary school, college, or graduate school. Since 1951, awardees have included eminent and less-widely-known but equally effective

  12. News & Announcements

    Science.gov (United States)

    1999-08-01

    Chicago Section's meeting in May 1999. Courses, Seminars, Meetings, Opportunities Grant Program for Senior Scientist Mentors The Camille and Henry Dreyfus Foundation announces a new initiative within its Special Grant Program in the Chemical Sciences: the Senior Scientist Mentors. Undergraduate participation in research is generally acknowledged to be one of the most effective ways for students to learn and appreciate chemistry. Key to a meaningful research experience is the advising and counseling a student can receive from leaders in chemical research. Application Details Emeritus faculty who maintain active research programs in the chemical sciences may apply for one of a limited number of awards that will allow undergraduates to do research under their guidance. Successful applicants, who are expected to be closely engaged in a mentoring relationship with the students, will receive grants of 10,000 annually for two years (20,000 total) for undergraduate stipends and modest research support. In approximately three pages, applicants should describe their ongoing research and the nature of the participation by undergraduates in the research activity. The role of the applicant as mentor should be clearly outlined. The application should also contain a curriculum vitae of no more than five pages that includes representative publications; a letter of support from the department chair that also commits appropriate space and facilities for the undergraduate participants; and a letter of support from a colleague (preferably from outside the department) who is familiar with the applicant's research and teaching. This initiative is open to all institutions that offer bachelor's or higher degrees in the chemical sciences. Use the standard cover page for the Special Grant Program in the Chemical Sciences, which is available at www.dreyfus.org. "Senior Scientist Mentors" should be entered as the project title. An original and five copies of the application are required

  13. 77 FR 60707 - National Toxicology Program Board of Scientific Counselors; Announcement of Meeting; Request for...

    Science.gov (United States)

    2012-10-04

    ... HUMAN SERVICES National Institutes of Health National Toxicology Program Board of Scientific Counselors... Toxicology Program (NTP) Board of Scientific Counselors (BSC). The NTP BSC, a federally chartered, external... authorities knowledgeable in fields such as toxicology, pharmacology, pathology, biochemistry, epidemiology...

  14. 78 FR 37821 - Tribal Self-Governance Program, Negotiation Cooperative Agreement, Announcement Type: New-Limited...

    Science.gov (United States)

    2013-06-24

    ... HUMAN SERVICES Indian Health Service Tribal Self-Governance Program, Negotiation Cooperative Agreement... (IHS) Office of Tribal Self-Governance (OTSG) is accepting limited competition Negotiation Cooperative Agreement applications for the Tribal Self-Governance Program (TSGP). This program is authorized under Title...

  15. 75 FR 64737 - Automated Commercial Environment (ACE): Announcement of a National Customs Automation Program...

    Science.gov (United States)

    2010-10-20

    ... National Customs Automation Program Test of Automated Manifest Capabilities for Ocean and Rail Carriers... Protection (CBP) will be conducting a National Customs Automation Program test concerning the transmission of...: Background The National Customs Automation Program (NCAP) was established in Subtitle B of Title VI--Customs...

  16. 76 FR 34246 - Automated Commercial Environment (ACE); Announcement of National Customs Automation Program Test...

    Science.gov (United States)

    2011-06-13

    ... National Customs Automation Program Test of Automated Procedures for In-Bond Shipments Transiting Through....S. Customs and Border Protection (CBP) plans to conduct a National Customs Automation Program ([email protected] . SUPPLEMENTARY INFORMATION: Background The National Customs Automation Program (NCAP) was...

  17. Differential effects of baseline drinking status : Effects of an alcohol prevention program targeting students and/or parents (PAS) among weekly drinking students

    NARCIS (Netherlands)

    Koning, Ina M.; Lugtig, Peter; Vollebergh, Wilma A M

    2014-01-01

    The effects of an intervention designed to prevent onset of weekly drinking in non drinking students (PAS) were investigated in the group of students that was already drinking at baseline. A cluster randomized trial was used including 3,490 Dutch early adolescents (M age. =. 12.66, SD=. 0.49)

  18. “Música em PAS”: music as an evaluation object of the program of serial university entrance examination of University of Brasília (PAS/UnB

    Directory of Open Access Journals (Sweden)

    Maria Cristina de C. C. de Azevedo

    2012-01-01

    Full Text Available This paper discusses the musical proposal to Program of Serial University Entrance Examination of University of Brasília (PAS/UnB. The discussion is based on author’s participation on elaboration, systematization, and review groups of 2001 and 2006 programs, as well her researches and her teacher training activities with PAS. The text presents the program, its evaluation conception and the music-pedagogical principles and purposes that guide the insertion of musical knowledge as compulsory evaluation’s object in the university entrance examination. The last program’s version has adopted an Evaluation’s Matrix with some music competences, abilities and evaluation’s objects. The development of music’s competences and abilities is oriented by a music repertoire that defi- nes the content and should be a way for development of musical practices and experiences (performance, improvisation and composition, reception (musical appraising and context. In this process, the schools and its music teachers are responsible for create learning and teaching situations where the musical experience could be celebrated in sense of to promote a musical significant learning experience and the student’s success in PAS/UnB exams.

  19. 75 FR 10496 - Tribal Self-Governance Program Planning Cooperative Agreement; Announcement Type: New Funding...

    Science.gov (United States)

    2010-03-08

    ... HUMAN SERVICES Indian Health Service Tribal Self-Governance Program Planning Cooperative Agreement... Self- Governance Program (TSGP), as authorized by Public Law 106-260, the Tribal Self-Governance... is designed to promote Self-Governance by enabling Tribes to assume control of Indian Health Service...

  20. 78 FR 24762 - National Toxicology Program Board of Scientific Counselors; Announcement of Meeting; Request for...

    Science.gov (United States)

    2013-04-26

    ... HUMAN SERVICES National Institutes of Health National Toxicology Program Board of Scientific Counselors... Toxicology Program (NTP) Board of Scientific Counselors (BSC). The NTP BSC, a federally chartered, external... quality. Its members are selected from recognized authorities knowledgeable in fields such as toxicology...

  1. 77 FR 67386 - Announcement of Funding Awards; Indian Community Development Block Grant Program; Fiscal Year 2012

    Science.gov (United States)

    2012-11-09

    ..., 523 Infrastructure. Ashmun Street, Sault Ste. Marie, MI 49783, (906) 635-6050. Seminole Nation... Native American Programs (ONAP) serving your area or Glenda Green, Director, Office of Native Programs, 451 7th Street SW., Washington, DC 20410, telephone number 202-402-6329. Hearing or speech-impaired...

  2. 75 FR 17745 - Tribal Management Grant Program; Announcement Type: New and Competing Continuation Discretionary...

    Science.gov (United States)

    2010-04-07

    ... Assistance Number(s): 93.228. Key Dates: Program Requirements Session: April 21-22 and May 5-6, 2010. Grant..., 2010. Receipt Date for Final Tribal Resolution: October 1, 2010. Review Date: October 4-8, 2010...-638, as amended. This program is described at 93.228 in the Catalog of Federal Domestic Assistance...

  3. News & Announcements

    Science.gov (United States)

    2000-02-01

    . Works well. Activity:CD Light: An Introduction to Spectroscopy. J. Chem. Educ. 1998, 75, 1568A (December 1998). Workshop?yes Booth?yes, with colored plastic onlynot solutions Notes:Can be difficult to measure and cut cardboard for spectroscope. Pre-made spectroscopes and partially constructed ones to show method could be provided. Needs good light source to work well. Activity:Cleaning Up with Chemistry: Investigating the Action of Zeolite in Laundry Detergent. J. Chem. Educ. 1999, 76, 1461A (October 1999). Workshop?yes Booth?could demonstrate tubes of soapy water with and without zeolite Notes:Need access to water. Quick and easy. More information about JCE Classroom Activities is available on JCE Online at: http://jchemed.chem.wisc.edu/AboutJCE/Features/JCE_CA/. Here you will find the notes described above and a list of all published Classroom Activities. The site is updated regularly. Awards Announced United Nations Environment Program The United Nations Environment Program (UNEP) has selected Mario J. Molina, professor of earth, atmosphere, and planetary sciences at Massachusetts Institute of Technology, as the winner of the 1999 UNEP Sasakawa Environment Prize. The prize, worth $200,000, is for his outstanding global contributions in the field of atmospheric chemistry. ACS Northeastern Section The Northeastern Section of the American Chemical Society has awarded the Henry A. Hill Award to Morton Z. Hoffman, professor of chemistry at Boston University. The award is given annually to a member of the section for outstanding service. Award Deadlines Mettler-Toledo Thermal Analysis Education Grant Mettler-Toledo has established a grant to honor Edith A. Turi of the Polymer Research Institute, Polytechnic University, Brooklyn, NY, for her lifelong contribution to the cause of thermal analysis education. The grant will be awarded on an annual basis to not-for-profit organizations in North America that confer degrees up to the Ph. D. level and provide or intend to provide

  4. 78 FR 55080 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to Massachusetts...

    Science.gov (United States)

    2013-09-09

    ... HUMAN SERVICES Administration for Children and Families Office of Refugee Resettlement Announcement of... Administration for Children and Families (ACF), Office of Refugee Resettlement (ORR) announces the award of a..., asylees, Amerasian Immigrants, Cuban and Haitian Entrants, Trafficking Victims and Iraqi/Afghani Special...

  5. 77 FR 65197 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the Research...

    Science.gov (United States)

    2012-10-25

    ... of Social Work, New York, NY AGENCY: Children's Bureau, Administration on Children, Youth and Families, Administration for Children and Families, Health and Human Services. ] ACTION: Announcement of... HUMAN SERVICES Administration for Children and Families Announcement of the Award of a Single-Source...

  6. 77 FR 38070 - Office of Refugee Resettlement; Announcing the Award of a Single-Source Program Expansion...

    Science.gov (United States)

    2012-06-26

    ... HUMAN SERVICES Administration for Children and Families Office of Refugee Resettlement; Announcing the... Shelter Care to Baptist Children and Family Services (BCFS) in San Antonio, TX AGENCY: Office of Refugee Resettlement, ACF, HHS. ACTION: The Office of Refugee Resettlement announces the award of a single-source...

  7. 78 FR 79477 - Announcement of Funding Awards, Choice Neighborhoods Grant Program, Fiscal Year 2013

    Science.gov (United States)

    2013-12-30

    ... program aims to transform neighborhoods of poverty into viable mixed-income neighborhoods with access to... Park--Broadway. Sacramento, 801 12th Street, Sacramento, CA 95814-2947. County of St. Louis, 41 South...

  8. Winners announced in Student Programs' sixth annual Home Sweet Home recipe contest

    OpenAIRE

    Dawson, Brandi

    2007-01-01

    Eight recipes were selected from the more than 250 submitted by students' family members during the sixth annual Home Sweet Home Recipe Contest sponsored by the Virginia Tech Office of Student Programs' Housing and Dining Services.

  9. 76 FR 21741 - Twenty-First Century Communications and Video Programming Accessibility Act; Announcement of Town...

    Science.gov (United States)

    2011-04-18

    ... Governmental Affairs Bureau, 202-418-2498 (voice), 202-418-1169 (TTY), or [email protected] (e-mail); or... gaps in video programming through the provision of video description on television and closed...

  10. 77 FR 5295 - Over-the-Road Bus Accessibility Program Announcement of Project Selections

    Science.gov (United States)

    2012-02-02

    ... Regional Office for grant-specific issues; or Blenda Younger, Office of Program Management, 202-366-4345... FTA's Transportation Electronic Awards Management System (TEAM) for the projects identified in Tables... under the Special Warranty Provisions of the Department of Labor Guidelines ``Section 5333(b), Federal...

  11. 78 FR 21395 - Announcement of Funding Awards, Choice Neighborhoods Grant Program, Fiscal Year 2012

    Science.gov (United States)

    2013-04-10

    ... community development centered on housing transformation. The program aims to transform neighborhoods of... (project is located in San Francisco, CA). City of Roanoke Redevelopment and 200,000 Lansdown Park and...; Croton Heights/Cottage Place Gardens of Yonkers, 1511 Central Park Avenue, neighborhood. Yonkers, NY...

  12. Should we be worried about the green paradox? Announcement effects of the Acid Rain Program

    NARCIS (Netherlands)

    Maria, di C.; Lange, Ian; Werf, van der E.

    2014-01-01

    This paper presents the first empirical test of the green paradox hypothesis, according to which well-intended but imperfectly implemented environmental policies may lead to detrimental outcomes due to supply side responses. We use the introduction of the Acid Rain Program in the U.S. as a case

  13. 78 FR 46339 - Medicare, Medicaid, and Children's Health Insurance Programs: Announcement of Temporary Moratoria...

    Science.gov (United States)

    2013-07-31

    ..., ``Health Care Fraud and Abuse Control Program Annual Report for Fiscal Year 2012.'' See http://oig.hhs.gov... surrounding counties to prevent and combat fraud, waste, and abuse. DATES: Effective Date: July 30, 2013. FOR... Secretary with new tools and resources to combat fraud, waste, and abuse in Medicare, Medicaid, and the...

  14. 77 FR 26751 - Integrated Risk Information System (IRIS); Announcement of 2012 Program

    Science.gov (United States)

    2012-05-07

    ... chemicals are withdrawn from the IRIS agenda: Chemical Cas No. alkylates various. bisphenol A 80-05-7. mirex... are nominated in the future, the IRIS Program will consider these nominations individually. Bisphenol A is withdrawn because EPA is awaiting further analysis and results from the U.S. Food and Drug...

  15. 77 FR 11127 - Medicaid Program; Announcement of Medicaid Recovery Audit Contractors (RACs) Contingency Fee Update

    Science.gov (United States)

    2012-02-24

    ..., for which Federal financial participation (FFP) will be available, that may be paid to Medicaid Recovery Audit Contractors (RAC) by State Medicaid programs as authorized by section 1902(a)(42)(B) of the Social Security Act (the Act), as amended by the Affordable Care Act, requiring States to establish...

  16. 76 FR 9789 - Office of Urban Indian Health Programs; Announcement Type: Limited Competition, Continuation...

    Science.gov (United States)

    2011-02-22

    ... benefits at lower costs. Medicare Part D is streamlined and improved to better connect people with their... therapy intervention counseling sessions, symptoms, incidence skills measure, peer and historical trauma... Indian Affairs (BIA) Relocation/Employment Assistance Programs (BIA Relocation) which enticed Indian...

  17. 78 FR 25291 - Announcement of Funding Awards; Section 3 Program Coordination and Implementation; Fiscal Year 2010

    Science.gov (United States)

    2013-04-30

    ... funding decisions made by the Department for funding under the Notice of Funding Availability (NOFA) for... under the Section 3 Program is 14.412.) Dated: April 18, 2013. John D. Trasvi a, Assistant Secretary for... Kansas City, 301 Valentine Reid, 816-777-2390. 7 50,000.00 East Armour Boulevard, Jackson, MO 64112-1254...

  18. 78 FR 8535 - Medicare Program: Comprehensive End-Stage Renal Disease Care Model Announcement

    Science.gov (United States)

    2013-02-06

    ... functional status, quality of life, and overall well-being, as well as increased beneficiary and caregiver... or enhancing the quality of care for Medicare, Medicaid, and Children's Health Insurance Program... an interdisciplinary care team that is led by a nephrologist, comprised of dialysis facilities...

  19. 77 FR 31618 - Medicaid Program; Announcement of Requirements and Registration for CMS Provider Screening...

    Science.gov (United States)

    2012-05-29

    ... identity and prior history of problems with Medicaid/CHIP or Medicare programs. d. Capability to identify... would be capable of risk scoring, credentialing validation, identity authentication, and sanction checks... estimate that the total prize amount for the competitions conducted as part of this Challenge will fall...

  20. Announcements of ECB unconventional programs: Implications for the sovereign risk of Italy

    OpenAIRE

    Falagiarda, Matteo; Reitz, Stefan

    2013-01-01

    This paper studies the effects of ECB communications about unconventional monetary policy operations on the perceived sovereign risk of Italy over the last five years. More than fifty events concerning non-standard operations are identified and classified with respect to the specific ECB program. The empirical results are derived from both an event-study analysis and a GARCH framework, which uses Italian long-term bond futures to disentangle expected from unexpected policy actions. We find th...

  1. News & Announcements

    Science.gov (United States)

    2001-08-01

    News from Journal House National Chemistry Week (NCW) right" alt="National Chemistry Week"> Celebrating Chemistry and Art is the theme of NCW 2001, to be held November 4-10, 2001. As you make plans for participating in the celebrations in your area, keep in mind that JCE is developing special materials on this theme, which will appear in our October issue: Classroom Activities, a comprehensive Illustrated Resource Paper, Report from Online, specially written brief articles illustrated in color, articles related to the theme, and CLIPs (Chemical Laboratory Information Profiles). Awards Announced Passer Award Passer Award recipients from the April 1 closing date are: George Bennett, Millikin University, Decatur, IL Daniel Berger, Bluffton College, Bluffton, OH Karen Dunlap, Sierra College, Rocklin, CA Myung-Hoon Kim, Georgia Perimeter College, Dunwoody, GA Cheryl Longfellow, Philadelphia University, Philadelphia, PA Jerry Maas, Oakton Community College, Des Plaines, IL Tim Royappa, University of West Florida, Pensacola, FL Visiting Scientist Award, Western Connecticut Section Diane Bunce, The Catholic University of America, has been selected as the 2001 Visiting Scientist of the Western Connecticut Section of the ACS. The award, presented annually since 1967, brings an outstanding chemical educator to visit high schools in Fairfield County, CT. In May, Bunce visited three high schools, Christian Heritage School, Fairfield High School, and Greenwich High School, where she interacted with teachers and students and presented lectures and demonstrations to several chemistry classes. She was also keynote speaker at the ACS local section's Education Night. The awardee is selected by a committee of university and high school teachers, industrial chemists, and the previous Visiting Scientist; there is an honorarium of 1500 plus expenses. Welch Award Roger D. Kornberg, a professor of structural biology at the Stanford University School of Medicine, received the 2001 Welch

  2. News & Announcements

    Science.gov (United States)

    1999-09-01

    Unification of Journal Options Beginning in 2000, the Journal subscription form will get much simpler and your Journal subscription will bring you even more than previously. Below is an outline of how the new system will work for individuals. Subscriptions for Individuals Beginning September 1, 1999, all Journal print subscriptionscurrent, continuing, new, and renewalwill bring you monthly print issues and give you full access to JCE Online+everything that we have online. If you don't want paper copy of your issue, there is a No-Print Optionwe donate your print copy to our Teacher Workshop Program and you have full access to everything online. If you do want both paper and online but don't want to keep back issuessaving storage spaceyou can purchase JCE CD each year. A chart illustrating this new system appears below. It lists all subscription choices for individuals in the U. S., for ACS Student Affiliates, and for non-U.S. individuals. Other Subscription Rates There are now two types of subscriptions for libraries. These are described under New IP-Address Option for Libraries, below. For information about Promotional (larger quantities for workshops, classes, etc.) or Gift Subscription Award Certificate rates, contact the Journal (jce@chem.wisc.edu); 1-800-991-5534 (U.S.) or 608/262-5153. Extensions for Current JCE Online Subscribers At present there are more than 1,000 subscribers to JCE Online+: we think of these as our technological pioneers. These subscribers will have their subscriptions automatically extended according to the scheme below. Online Subscription Expires JCE Subscriptions Extended By Sept. 1, 1999 - Feb. 29, 2000 3 months Mar. 1, 2000 - Aug. 31, 2000 6 months Sept. 1, 2000 - Feb. 28, 2001 9 months Mar. 1, 2001 - Aug. 31, 2001 12 months Sept. 1, 2001 - Feb. 28, 2002 15 months Mar. 1, 2002 - Aug. 31, 2002 18 months Sept. 1, 2002 - Feb. 28, 2003 21 months Easy Access to JCE Online For quick and easy access to JCE Online, do this. Get the carrier

  3. 47 CFR 11.46 - EAS public service announcements.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false EAS public service announcements. 11.46 Section...) Organization § 11.46 EAS public service announcements. EAS Participants may use Public Service Announcements or obtain commercial sponsors for announcements, infomercials, or programs explaining the EAS to the public...

  4. Publisher's Announcement

    Science.gov (United States)

    Scriven, Neil

    2003-12-01

    We are delighted to announce that the new Editor-in-Chief of Journal of Physics A: Mathematical and General for 2004 will be Professor Carl M Bender of Washington University, St. Louis. Carl will, with the help of his world class editorial board, maintain standards of scientific rigour whilst ensuring that research published is of the highest importance. Carl attained his first degree in physics at Cornell University before studying for his PhD at Harvard. He later worked at The Institute for Advanced Study in Princeton and at MIT before assuming his current position at Washington University, St Louis. He has been a visiting professor at Technion, Haifa, and Imperial College, London and a scientific consultant for Los Alamos National Laboratory. His main expertise is in using classical applied mathematics to solve a broad range of problems in high-energy theoretical physics and mathematical physics. Since the publication of his book Advanced Mathematical Methods for Scientists and Engineers, written with Steven Orszag, he has been regarded as an expert on the subject of asymptotic analysis and perturbative methods. `Carl publishes his own internationally-important research in the journal and has been an invaluable, energetic member of the Editorial Board for some time' said Professor Ed Corrigan, Carl's predecessor as Editor, `he will be an excellent Editor-in-Chief'. Our grateful thanks and best wishes go to Professor Corrigan who has done a magnificent job for the journal during his five-year tenure.

  5. 77 FR 38637 - Announcement of the Award of Single-Source Cooperative Agreement to Rubicon Programs, Inc., in...

    Science.gov (United States)

    2012-06-28

    ... designed to offer community-centered, pre- and post- release responsible fatherhood and supportive services... HUMAN SERVICES Administration for Children and Families Announcement of the Award of Single-Source... Richmond, CA, to support Community-Centered Responsible Fatherhood Ex-Prisoner Reentry activities to...

  6. 77 FR 65196 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the Tribal Law...

    Science.gov (United States)

    2012-10-25

    ... the Child and Family Services Improvement and Innovation Act (Pub. L. 112-34) and explore the need for... HUMAN SERVICES Administration for Children and Families Announcement of the Award of a Single-Source...: Children's Bureau, Administration on Children, Youth and Families, Administration for Children and Families...

  7. 77 FR 65197 - Announcement of the Award of a Single-Source Program Expansion Supplement Grant to the University...

    Science.gov (United States)

    2012-10-25

    ... HUMAN SERVICES Administration for Children and Families Announcement of the Award of a Single-Source... Database regulations effectively. SUMMARY: The Administration for Children and Families (ACF), Children's..., Administration on Children, Youth and Families, Administration for Children and Families, Health and Human...

  8. 77 FR 9955 - Announcement of Funding Awards for the Community Challenge Planning Grant Program for Fiscal Year...

    Science.gov (United States)

    2012-02-21

    ... Fiscal Year 2011 AGENCY: Office of Sustainable Housing and Communities, HUD. ACTION: Announcement of... Department in a competition for funding under the Fiscal Year 2011 (FY 2011) Notice of Funding Availability... Hampshire Housing Finance Authority, 32 Constitution 1,000,000 Drive, Bedford, NH: New Hampshire 03110-6000...

  9. Announcements to Attentive Agents

    DEFF Research Database (Denmark)

    Bolander, Thomas; van Ditmarsch, Hans; Herzig, Andreas

    2016-01-01

    In public announcement logic it is assumed that all agents pay attention to the announcement. Weaker observational conditions can be modelled in action model logic. In this work, we propose a version of public announcement logic wherein it is encoded in the states of the epistemic model which...... agents pay attention to the announcement. This logic is called attention-based announcement logic. We give an axiomatization of the logic and prove that complexity of satisfiability is the same as that of public announcement logic, and therefore lower than that of action model logic. An attention...

  10. PAs: Public awareness and the popular media.

    Science.gov (United States)

    Carter, Reginald D; Ballweg, Ruth

    2017-07-01

    From the very beginning, popular media has played an essential role in driving public awareness and recognition of physician assistants (PAs) as major contributors to healthcare. But for PAs, popular media can be a double-edged sword. Over time, the roles of PAs have evolved from bit players to leading characters on television medical dramas. Even so, on some occasions, the roles of PAs have been marginalized and misrepresented. In the future, the PA profession will need to remain vigilant about how PAs are portrayed in the popular media and must learn how to use the full benefit of the media to promote the profession's diversity, flexibility, collegiality, and civic-mindedness.

  11. A history of US Army PAs.

    Science.gov (United States)

    Chalupa, Robyn L; Marble, W Sanders

    2017-11-01

    The US military has a long tradition of using physician assistants (PAs). The Army began using PAs in 1971 in an effort to supplement the physicians and surgeons in the medical corps. As their numbers grew, PAs gradually replaced general medical officers assigned to battalions. Later, specialty positions developed in aviation medicine, orthopedics, and emergency medicine. The need for a PA serving as an adviser in the major commands slowly developed at all levels of leadership. In 2015, the Army removed limitations on female PAs assigned to combat units. PAs lead in tactical and clinical settings, filling command roles, senior clinical positions, and administrative leadership roles.

  12. 75 FR 16493 - Announcement of Funding Awards for the Public and Indian Housing Family Self-Sufficiency Program...

    Science.gov (United States)

    2010-04-01

    ...-Sufficiency Program Under the Resident Opportunity and Self-Sufficiency (ROSS) Program for Fiscal Year 2009...-Sufficiency Program under the Resident Opportunity and Self-Sufficiency (ROSS) Program for Fiscal Year 2009...: For questions concerning the FY 2009 Public and Indian Housing Family Self-Sufficiency Program under...

  13. Effectiveness of a physical activity program on cardiovascular disease risk in adult primary health-care users: the “Pas-a-Pas” community intervention trial

    Directory of Open Access Journals (Sweden)

    Victoria Arija

    2017-06-01

    Full Text Available Abstract Background Physical activity is a major, modifiable, risk factor for cardiovascular disease (CVD that contributes to the prevention and management of CVD. The aim of this study was to assess the short- and medium-term effectiveness of 9 months of a supervised physical activity program, including sociocultural activities, on CVD risk in adults. Methods Multicentered, randomized, controlled community intervention involving 364 patients in four primary care centers. The participants were randomly assigned to a Control Group (CG = 104 or Intervention Group (IG = 260; mean age 65.19 years; 76.8% women. The intervention consisted of 120 min/week walking (396 METs/min/week and sociocultural gathering once a month. Clinical history, physical activity, dietary intake, CVD risk factors (smoking, systolic and diastolic blood pressure, weight, waist circumference, BMI, total cholesterol, LDL- and HDL-cholesterol, triglycerides, glycosylated hemoglobin and glucose and global CVD risk were assessed at baseline and at the end of the intervention and multivariate models were applied to the data. Incidence of adverse cardiovascular events and continued adherence to the physical activity were assessed 2 years after intervention. Results At the end of the intervention period, in the IG relative to the CG group, there was a significant increase in physical activity (774.81 METs/min/week, a significant change during the intervention period in systolic blood pressure (−6.63 mmHg, total cholesterol (−10.12 mg/dL and LDL-cholesterol (−9.05 mg/dL even after adjustment for potential confounders. At 2 years after the intervention, in the IG, compared with the CG, tthe incidence of adverse cardiovascular events was significantly lower (2.5% vs. 10.5% and the adherence to regular physical activity was higher (72.8% vs 27.2% in IG compared to CG. Conclusions This community-based physical activity program improved cardiovascular health in the short

  14. Patient satisfaction with PAs in the Netherlands.

    Science.gov (United States)

    Meijer, Koos; Kuilman, Luppo

    2017-05-01

    Physician assistants (PAs) were introduced in the Netherlands in 2002 and are now widely deployed. However, little is known about patient satisfaction with Dutch PAs. A comparative study of patient satisfaction was undertaken in the primary care setting. Patients seen by general practitioners (GPs) and PAs were surveyed using the Consumer Quality Index, a European quality survey instrument. Quality of performance indicators included patient satisfaction, effectiveness of treatment, and safety of treatment. The results found that few differences emerged, and Dutch patients appear to be as satisfied with the care received by PAs as with GPs.

  15. The enhanced forest inventory and analysis program of the USDA forest service: historical perspective and announcements of statistical documentation

    Science.gov (United States)

    Ronald E. McRoberts; William A. Bechtold; Paul L. Patterson; Charles T. Scott; Gregory A. Reams

    2005-01-01

    The Forest Inventory and Analysis (FIA) program of the USDA Forest Service has initiated a transition from regional, periodic inventories to an enhanced national FIA program featuring annual measurement of a proportion of plots in each state, greater national consistency, and integration with the ground sampling component of the Forest Health Monitoring (FHM) program...

  16. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 2; Issue 1. Information and Announcements. Information and Announcements Volume 2 Issue 1 January 1997 pp 96-96. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/002/01/0096-0096. Resonance ...

  17. 77 FR 27475 - Announcement of Funding Awards; Choice Neighborhoods Grant Program for Fiscal Years (FY) 2010 and...

    Science.gov (United States)

    2012-05-10

    ... transformation. The program aims to transform neighborhoods of poverty into viable mixed-income neighborhoods.... Housing Authority of the City 170,000 Civic Park Apartments; of Salisbury, NC, 200 S. Westend neighborhood...; Mantua PA 19104-2047. neighborhood. Norfolk Redevelopment and 250,000 Tidewater Park Gardens; Housing...

  18. 77 FR 65895 - Announcement of the Award of Four Single-Source Program Expansion Supplement Grants To Support...

    Science.gov (United States)

    2012-10-31

    ... Program Expansion Supplement Grants To Support Activities Associated With the Tribal Early Learning... expansion supplement grants to Tribal Maternal, Infant, and Early Childhood Home Visiting (MIECHV) grantees to support their activities as participants in the Tribal Early Learning Initiative. SUMMARY: The...

  19. 76 FR 67194 - Administration on Children, Youth and Families Announces the Award of a Single-Source Program...

    Science.gov (United States)

    2011-10-31

    ... service agencies; so that they better serve victims of domestic violence and their children who are... Technical Assistance to the Pennsylvania Coalition Against Domestic Violence in Harrisburg, PA AGENCY... Program Expansion Supplement to Pennsylvania Coalition Against Domestic Violence, National Resource Center...

  20. 76 FR 45282 - Announcement of Funding Awards for the HUD-Veterans Affairs Supportive Housing (HUD-VASH) Program...

    Science.gov (United States)

    2011-07-28

    ... Street S Tacoma WA 98444 $179,013 25 SPOKANE HOUSING AUTHORITY 55 W Mission Avenue........ Spokane WA...-VASH) Program for Fiscal Years (FY) 2010 AGENCY: Office of Public and Indian Housing, HUD. ACTION..., Office of Public and Indian Housing, Department of Housing and Urban Development, 451 7th Street, SW...

  1. 77 FR 58403 - Announcing the Award of 24 Single-Source Program Expansion Supplement Grants Under the...

    Science.gov (United States)

    2012-09-20

    ... Supplement Grants Under the Unaccompanied Alien Children's Shelter Care Program AGENCY: Office of Refugee... grantees provide a range of custodial/residential shelter care and services for recently arrived... referrals within specified timeframes and ] provides a range of custodial/residential shelter care and...

  2. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 1. Science Academies' Refresher Course on Quantum Mechanics and Nuclear Physics. Information and Announcements Volume 21 Issue 1 January 2016 pp 105-105 ...

  3. News and Announcements

    Science.gov (United States)

    1999-06-01

    1999 EAS Awards The Eastern Analytical Symposium (EAS) announces the winners of their 1999 awards, which will be presented during their annual meeting, to be held November 14-19, 1999, at the Garden State Convention Center in Somerset, NJ. ACS Analytical Chemistry Division, Findeis Young Investigator Award David Clemmer, Indiana University EAS Award for Achievements in Separation Science Milton L. Lee, Brigham Young University EAS Award for Achievements in Near-Infrared Spectroscopy Phil Williams, Grain Research Laboratory, Winnipeg, Canada EAS Award for Achievements in Magnetic Resonance Frank A. L. Anet, University of California, Los Angeles (Emeritus) EAS Award for Outstanding Achievements in the Fields of Analytical Chemistry Catherine Fenselau, University of Maryland at College Park Galactic Industries Award for Achievements in Chemometrics Harald Martens, Norwegian University of Science and Technology Proposal Deadlines National Science Foundation Division of Undergraduate Education (DUE) Course, Curriculum, and Laboratory Improvement (CCLI) June 7, 1999 NSF Collaboratives for Excellence in Teacher Preparation (CETP) Preliminary proposals, Track 1 May 1, 1999 Formal proposals, Track 1 September 1, 1999 DUE online 1999 guidelines, NSF 99-53 available at http://www.nsf.gov/cgi-bin/getpub?nsf9953 For further information about NSF DUE programs consult the DUE Web site, http://www.ehr.nsf.gov/EHR/DUE/start.htm. Program deadlines are at http://www.ehr.nsf.gov/EHR/DUE/programs/programs.htm . To contact the DUE Information Center, phone: 703/306-1666; email: undergrad@nsf.gov. The Camille and Henry Dreyfus Foundation, Inc. Camille Dreyfus Teacher-Scholar Awards Program: November 16, 1998 Henry Dreyfus Teacher-Scholar Awards Program: July 1, 1999 New Faculty Awards Program: May 14, 1999 Faculty Start-up Grants for Undergraduate Institutions: May 14, 1999 Scholar/Fellow Program for Undergraduate Institutions: July 1, 1999 Special Grant Program in the Chemical Sciences

  4. Faux Pas Test in schizophrenic patients

    Directory of Open Access Journals (Sweden)

    Juliana Negrão

    2016-03-01

    Full Text Available ABSTRACT Objective The aim of this study is to validate the adult version of “Faux Pas Recognition Test” created by Stone and colleagues (1998 as a reliable instrument assess and discriminate social cognition among schizophrenia patients and healthy controls. Methods This is a cross-sectional study with a total of 196 participants (mean age = 26.45; CI (95% [25.10; 27.83] 51% male. From those, 44 (22.4% patients with schizophrenia and 152 (77.6% healthy controls. The participants answered a short version of the Faux Pas Recognition Test, composed by 10 stories. Results Significant differences were found between both groups regarding their scores on Faux Pas Recognition Test (p = 0.003. Patients with schizophrenia had lower score, compared to healthy controls. Story 14 was the best to distinguish both groups, and Story 16, the worst. Among the questions of Faux Pas stories, the one related to intuition presented the most significant difference between the groups (p = 0.001, followed by the one related to understanding (p = 0.003. Conclusion The Brazilian version of the Faux Pas Recognition Test is a valid test to assess social cognition in schizophrenia and can be an important instrument to be used on the clinical practice.

  5. Information and Announcement

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 7. Silver Jubilee Meetings of the Ethological Society of India and National Symposium on Behaviour, December 28-30, 1996. Information and Announcements Volume 1 Issue 7 July 1996 pp 96-96 ...

  6. Information and Announcements -90 ...

    Indian Academy of Sciences (India)

    Information and Announcements. India Wins 1 Gold, 3 Silver and 1 Bronze Medals at the 37th IMO ... such that. LAPB -LACB = LAPC -LABC. Let D, E be the incen tres of triangles AP B ,. APC respectively. Show that AP, BD and. CE meet at a point. (Canada). 3. Let S = {O, 1, 2, 3, ... } be the set of non-negative integers.

  7. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 12. Refresher Course in 'Topics in Mathematics and Physics'. Information and Announcements Volume 11 Issue 12 December 2006 pp 87-87. Fulltext. Click here to view fulltext PDF. Permanent link:

  8. Information and Announcements -96 ...

    Indian Academy of Sciences (India)

    Information and Announcements. Indian Team to the 38th International Mathematical Olympiad. As a result of continuous evaluation of the participants at the IMO Training Camp held from May 6 to June 2,1997 at the Homi Bhabha Centre for Science Education, Mumbai, the following students have been selected to ...

  9. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 23; Issue 1. Resonance congratulates the recipients of INSA Teachers Award 2017. Information and Announcements Volume 23 Issue 1 January 2018 pp 129-131. Fulltext. Click here to view fulltext PDF. Permanent link:

  10. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 3. Ramanujan Mathematical Society. Information and Announcements Volume 12 Issue 3 March 2007 pp 76-76. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/012/03/0076-0076. Resonance ...

  11. Information and Announcements

    Indian Academy of Sciences (India)

    IAS Admin

    2015-02-28

    Feb 28, 2015 ... RESONANCE | February 2015. 184. Information and Announcements. Science Academies' Seventieth Refresher Course in Experimental Physics at Department of Physics, Goa University, Goa. 13 to 28 May 2015. Sponsored by Indian Academy of Sciences, Bangalore, Indian National Science Academy,.

  12. Information and Announcements

    Indian Academy of Sciences (India)

    IAS Admin

    2015-03-15

    Mar 15, 2015 ... RESONANCE | March 2015. Information and Announcements ... 2: Angular momentum theory and identical particles and spin; Module 3: Perturbation theory (degenerate and non- degenerate) and scattering theory; Module 4: Quantum theory of radiation and Relativistic Quantum mechanics-. Klein-Gordon ...

  13. Information and Announcements

    Indian Academy of Sciences (India)

    [1] R Courant and H Robbins, What is Mathematics?, Second Edition. (revised by Ian Stewart), Oxford University Press, 1996. [2] A Sitaram, The isoperime-tric problem, Resonance, Vol. 2, No.9, pp. 65-68, 1997. Information and Announcements. Drosophila Stocks Available for Classroom Studies. Drosophila is one of the ...

  14. Information and Announcements

    Indian Academy of Sciences (India)

    Information and Announcements. Refresher Course in Theoretical Physics. Sponsored by. INDIAN ACADEMY OF SCIENCES, Bangalore. 49 Some Aspects of Convexity. V S Sunder. 60 The Importance of Systematics. T C Narendran. RESEARCH NEWS. 97 Amartya Sen and the Mathematics of. Collective Choice. Bhaskar ...

  15. Information and Announcements

    Indian Academy of Sciences (India)

    Information and Announcements. Refresher Course on Quantum Chemistry sponsored by Indian Academy of Sciences, ... Sen, E D Jemmis, M Durga Prasad, T P Radhakrishnan, University of Hyderabad, Hyderabad,. M V Rajasekharan, School of <;:hemistry, Indian Institute of Technology, Madras, S R Gadre, Department.

  16. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 22; Issue 3. Science Academies' Refresher Course on Statistical Physics and its Application. Information and Announcements Volume 22 Issue 3 March 2017 pp 327-327. Fulltext. Click here to view fulltext PDF. Permanent link:

  17. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 12. India to Host - International Chemistry Olympiad 2001. Arvind Kumar. Information and Announcements Volume 5 Issue 12 December 2000 pp 94-94. Fulltext. Click here to view fulltext PDF. Permanent link:

  18. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 21; Issue 10. Science Academies Refresher Course on Immunology Laboratory Techniques Using Fish Model at School of Life Sciences. Information and Announcements Volume 21 Issue 10 October 2016 pp 963-963 ...

  19. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 11. Nobel Prize 2009. Information and Announcements Volume 14 Issue 11 November 2009 pp 1132-1132. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/014/11/1132-1132. Resonance – Journal ...

  20. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 11. Nobel Prize 2008. Information and Announcements Volume 13 Issue 11 November 2008 pp 1087-1087. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/013/11/1087-1087. Resonance – Journal ...

  1. Information and Announcements

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 3. Refresher Course in Animal Tissue Culture. Information and Announcements Volume 14 Issue 3 March 2009 pp 307-307. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/014/03/0307-0307 ...

  2. 78 FR 19735 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in...

    Science.gov (United States)

    2013-04-02

    ... Employment and Training Administration. Announcement Regarding a Change in Eligibility for Unemployment...: Notice. SUMMARY: Announcement regarding a change in eligibility for Unemployment Insurance (UI) claimants..., South Carolina and Texas in the Emergency Unemployment Compensation 2008 (EUC08) Program, and the...

  3. Setting the PAS, the role of circadian PAS domain proteins during environmental adaptation in plants.

    Science.gov (United States)

    Vogt, Julia H M; Schippers, Jos H M

    2015-01-01

    The per-ARNT-sim (PAS) domain represents an ancient protein module that can be found across all kingdoms of life. The domain functions as a sensing unit for a diverse array of signals, including molecular oxygen, small metabolites, and light. In plants, several PAS domain-containing proteins form an integral part of the circadian clock and regulate responses to environmental change. Moreover, these proteins function in pathways that control development and plant stress adaptation responses. Here, we discuss the role of PAS domain-containing proteins in anticipation, and adaptation to environmental changes in plants.

  4. News and Announcements

    Science.gov (United States)

    1999-02-01

    News from Journal House Conceptual Questions and Challenge Problems Many readers are trying to modify the way they teach and in so doing are trying to write new types of questions and problems. The Journal has a new online resource, the JCE Internet Conceptual Questions and Challenge Problems Web site, http://jchemed.chem.wisc.edu/JCEWWW/Resources/CQandChP/index.html . The site is a source of questions and problems that can be used in teaching and assessing conceptual understanding and problem solving in chemistry. Here you can find a library of free-response and multiple-choice conceptual questions and challenge problems, tips for writing these questions and problems, and a discussion of types of concept questions. This site is intended to be a means of sharing conceptual questions and challenge problems among chemical educators. It will be as inclusive as possible, and to achieve this readers need to share their questions and alert the authors to references or Web sites. The screen captures shown below should provide a feeling for what you will find when you visit the site. The authors, William R. Robinson and Susan C. Nurrenbern, welcome additions to the library of conceptual questions or other comments or suggestions. Contact them by email, fax, or regular mail. William R. Robinson and Susan C. Nurrenbern, Department of Chemistry, Purdue University, West Lafayette, IN 47907-1393. Bill: phone: 765/494-5453; fax: 765/494-0239; email: wrrobin@purdue.edu. Sue: phone: 765/494-0823; fax: 765/494-0239; email: nurrenbe@purdue.edu. fax: 765/494-0239. 1998 Ford Foundation Fellowships The National Research Council has announced the recipients of the 1998 fellowships for minority scholars. Three categories of fellowships were awarded: 50 to beginning graduate students, 33 to students writing their dissertations, and 28 to recent Ph.D. recipients. There were about 1,000 applicants. For information about the next competition contact the Fellowship Office of the National

  5. The role of PAS kinase in PASsing the glucose signal.

    Science.gov (United States)

    Grose, Julianne H; Rutter, Jared

    2010-01-01

    PAS kinase is an evolutionarily conserved nutrient responsive protein kinase that regulates glucose homeostasis. Mammalian PAS kinase is activated by glucose in pancreatic beta cells, and knockout mice are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet. Yeast PAS kinase is regulated by both carbon source and cell integrity stress and stimulates the partitioning of glucose toward structural carbohydrate biosynthesis. In our current model for PAS kinase regulation, a small molecule metabolite binds the sensory PAS domain and activates the enzyme. Although bona fide PAS kinase substrates are scarce, in vitro substrate searches provide putative targets for exploration.

  6. News and Announcements

    Science.gov (United States)

    1999-05-01

    career, I have no illusions about the complexities involved in implementing change. Yet there is really no choice if we are to survive and thrive as a nation. We must shine a strong spotlight on education, with special and lasting emphasis on science and technology, and the real-world connections so apparent to us in chemistry and all the sciences. Lab Safety Training The Laboratory Safety Workshop announces laboratory safety training in six locations this summer. The 24-hour short courses are for secondary and college/university science educators. The dates and locations are: June 16-19: TBA, Minneapolis, MN June 23-26: Southwest Texas State Univ., San Marcos, TX July 7-10: University of Nevada-Reno, Reno, NV July 14-17: Northeastern University, Boston, MA August 3-6: College of Charleston, Charleston, SC August 16-19: TBA, Seattle, WA For further information contact Laboratory Safety Workshop, 192 Worcester Road, Natick, MA 01760-2552; phone: 508/647-1900; fax: 508/647-0062; email: lswpfm@aol.com. Proposal Deadlines National Science Foundation Division of Undergraduate Education (DUE) Course, Curriculum, and Laboratory Improvement (CCLI) June 7, 1999 NSF Collaboratives for Excellence in Teacher Preparation (CETP) Preliminary proposals, Track 1 May 1, 1999 Formal proposals, Track 1 September 1, 1999 DUE online 1999 guidelines, NSF 99-53 available at http://www.nsf.gov/cgi-bin/getpub?nsf9953 For further information about NSF DUE programs consult the DUE Web site at http://www.ehr.nsf.gov/EHR/DUE/start.htm. Program deadlines are at http://www.ehr.nsf.gov/EHR/DUE/programs/programs.htm . Contact the DUE Information Center at phone: 703/306-1666; email: undergrad@nsf.gov. The Camille and Henry Dreyfus Foundation, Inc. Camille Dreyfus Teacher-Scholar Awards Program: November 16, 1998 Henry Dreyfus Teacher-Scholar Awards Program: July 1, 1999 New Faculty Awards Program: May 14, 1999 Faculty Start-up Grants for Undergraduate Institutions: May 14, 1999 Scholar/Fellow Program for

  7. Manual for THOR-AirPAS - air pollution assessment system

    DEFF Research Database (Denmark)

    Jensen, Steen Solvang; Ketzel, Matthias; Brandt, Jørgen

    The report provides an outline of the THOR-AirPAS - air pollution assessment system and a brief manual for getting started with the air quality models and input data included in THOR-AirPAS.......The report provides an outline of the THOR-AirPAS - air pollution assessment system and a brief manual for getting started with the air quality models and input data included in THOR-AirPAS....

  8. Evolution of PAS domains and PAS-containing genes in eukaryotes.

    Science.gov (United States)

    Mei, Qiming; Dvornyk, Volodymyr

    2014-08-01

    The PAS domains are signal modules, which are widely distributed in proteins across all kingdoms of life. They are common in photoreceptors and transcriptional regulators of eukaryotic circadian clocks q(bHLH-PAS proteins and PER in animals; PHY and ZTL in plants; and WC-1, 2, and VVD in fungi) and possess mainly protein-protein interaction and light-sensing functions. We conducted several evolutionary analyses of the PAS superfamily. Although the whole superfamily evolved primarily under strong purifying selection (average ω ranges from 0.0030 to 0.1164), some lineages apparently experienced strong episodic positive selection at some periods of the evolution. Although the PAS domains from different proteins vary in sequence and length, but they maintain a fairly conserved 3D structure, which is determined by only eight residues. The WC-1 and WC- 2, bHLH-PAS, and P er genes probably originated in the Neoproterozoic Era (1000-542 Mya), plant P hy and ZTL evolved in the Paleozoic (541-252 Mya), which might be a result of adaptation to the major climate and global light regime changes having occurred in those eras.

  9. Le droit de ne pas croire

    Directory of Open Access Journals (Sweden)

    Pascal Engel

    2012-07-01

    Full Text Available Le principe des raisons suffisantesBertrand Russell écrit, non sans une sérieuse dose d’ironie :Je voudrais proposer à la considération bienveillante du lecteur une doctrine qui, je le crains, peut apparaître comme étant brutalement paradoxale et subversive. La doctrine en question est : il n’est pas souhaitable de croire une proposition quand on n’a aucune raison que ce soit de supposer qu’elle soit vraie. Je dois bien sûr admettre que si une telle opinion devenait commune, elle transformera...

  10. Faculty pilot sites announced.

    Science.gov (United States)

    2000-11-01

    From a total of 33 submissions, four pilot sites for the Faculty of Emergency Nursing have now been announced by the RCN A&E Nursing Association. They are the University of Hospital Wales, Cardiff, Royal Gwent Hospital, Newport, Neville Hall, Abergavenny, and Royal Glamorgan Hospital, Llantrisant (linked with University of Wales College of Medicine); City Hospital, Sunderland, Queen Elizabeth Hospital, Gateshead and Dryburn Hospital, Durham (linked with University of Sunderland); Altnagalvin Hospital Health and Social Services Trust, Belfast City Hospital, Craigavon Area Hospitals Trust, Royal Hospitals Trust, Belfast and Ulster Community and Hospitals Trust (linked with University of Ulster); and Bart's and London NHS Trust, Newham Healthcare and Homerton Hospital NHS Trust (linked with City University). Rob Crouch, Chair, Faculty Project Management Group said 'This is an exciting step for the Faculty concept where we can begin to turn the work of the last five years into reality'.

  11. News and Announcements

    Science.gov (United States)

    1999-04-01

    Biochemistry at the University of Colorado at Boulder are offering a three-day symposium on natural products which include pharmaceuticals, nutraceuticals, and consumer products, to be held May 19-21, 1999. For further information or to make arrangements to attend, contact University of Colorado at Boulder, Attn: Rosemary Trujillo, Campus Box 215, Boulder, CO 80309-0215; email: rosemary.trujillo@colorado.edu; fax: 303/492-0439. Workshops for Small-Scale Chemistry The Center for Science, Mathematics and Technology Education at Colorado State University announces two workshop programs for summer 1999. Interested community college faculty are invited to apply for the Small-Scale Chemistry for Pollution Prevention Summer Institute, June 7-18, 1999. The Institute features hands-on training in small-scale chemistry laboratory techniques. Travel to Fort Collins, CO, lodging, per diem, and classroom/laboratory materials are funded for selected participants with a grant from the U.S. Environmental Protection Agency in collaboration with the Partnership for Environmental Technology Education (PETE). For more information contact Barry Carroll by email: barry_carroll@csmate.colostate.edu; phone: 970/491-1700, or access http://www.csmate.colostate.edu/Programs/PETE_Page.html. Interested high school teachers are invited to apply for two one-week workshops in Small-Scale Chemistry Laboratory for the Regular Chemistry Course (June 21-25, 1999) and Small-Scale Chemistry Laboratory for Advanced Placement Chemistry (June 28-July 2, 1999). The workshops feature hands-on training in small-scale chemistry laboratory techniques. Classroom/laboratory materials, books, and two graduate credits are included in the $395 fee for each course. For more information contact Courtney Butler by email: courtney@ csmate.colostate.edu, phone: 970/491-1700, or access http://www.csmate.colostate.edu/. 16th BCCE: Call for Suggestions The 16th Biennial Conference on Chemical Education will be held at the University

  12. Spanish validation of the Premorbid Adjustment Scale (PAS-S).

    Science.gov (United States)

    Barajas, Ana; Ochoa, Susana; Baños, Iris; Dolz, Montse; Villalta-Gil, Victoria; Vilaplana, Miriam; Autonell, Jaume; Sánchez, Bernardo; Cervilla, Jorge A; Foix, Alexandrina; Obiols, Jordi E; Haro, Josep Maria; Usall, Judith

    2013-02-01

    The Premorbid Adjustment Scale (PAS) has been the most widely used scale to quantify premorbid status in schizophrenia, coming to be regarded as the gold standard of retrospective assessment instruments. To examine the psychometric properties of the Spanish version of the PAS (PAS-S). Retrospective study of 140 individuals experiencing a first episode of psychosis (n=77) and individuals who have schizophrenia (n=63), both adult and adolescent patients. Data were collected through a socio-demographic questionnaire and a battery of instruments which includes the following scales: PAS-S, PANSS, LSP, GAF and DAS-sv. The Cronbach's alpha was performed to assess the internal consistency of PAS-S. Pearson's correlations were performed to assess the convergent and discriminant validity. The Cronbach's alpha of the PAS-S scale was 0.85. The correlation between social PAS-S and total PAS-S was 0.85 (pPAS-S and total PAS-S it was 0.53 (pPAS-S scale, with a significance value less than 0.001. There was a relationship between negative symptoms and social PAS-S (0.20, pPAS-S (0.22, pPAS-S. However, there was a correlation between academic PAS-S and general subscale of the PANSS (0.19, pPAS-S was related to disability measures (DAS-sv); and academic PAS-S showed discriminant validity with most of the variables of social functioning. PAS-S did not show association with the total LSP scale (discriminant validity). The Spanish version of the Premorbid Adjustment Scale showed appropriate psychometric properties in patients experiencing a first episode of psychosis and who have a chronic evolution of the illness. Moreover, each domain of the PAS-S (social and academic premorbid functioning) showed a differential relationship to other characteristics such as psychotic symptoms, disability or social functioning after onset of illness. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. PUBLISHER'S ANNOUNCEMENT: Editorial developments

    Science.gov (United States)

    2009-01-01

    We are delighted to announce that from January 2009, Professor Murray T Batchelor of the Australian National University, Canberra will be the new Editor-in-Chief of Journal of Physics A: Mathematical and Theoretical. Murray Batchelor has been Editor of the Mathematical Physics section of the journal since 2007. Prior to this, he served as a Board Member and an Advisory Panel member for the journal. His primary area of research is the statistical mechanics of exactly solved models. He holds a joint appointment in mathematics and physics and has held visiting positions at the Universities of Leiden, Amsterdam, Oxford and Tokyo. We very much look forward to working with Murray to continue to improve the journal's quality and interest to the readership. We would like to thank our outgoing Editor-in-Chief, Professor Carl M Bender. Carl has done a magnificent job as Editor-in-Chief and has worked tirelessly to improve the journal over the last five years. Carl has been instrumental in designing and implementing strategies that have enhanced the quality of papers published and service provided by Journal of Physics A: Mathematical and Theoretical. Notably, under his tenure, we have introduced the Fast Track Communications (FTC) section to the journal. This section provides a venue for outstanding short papers that report new and timely developments in mathematical and theoretical physics and offers accelerated publication and high visibility for our authors. During the last five years, we have raised the quality threshold for acceptance in the journal and now reject over 60% of submissions. As a result, papers published in Journal of Physics A: Mathematical and Theoretical are amongst the best in the field. We have also maintained and improved on our excellent receipt-to-first-decision times, which now average less than 50 days for papers. We have recently announced another innovation; the Journal of Physics A Best Paper Prize. These prizes will honour excellent papers

  14. 76 FR 18513 - Announcement of Grant Application Deadlines and Funding Levels

    Science.gov (United States)

    2011-04-04

    ... Services Grant Program. Announcement Type: Initial announcement. Catalog of Federal Domestic Assistance... health care services; health education programs; health care job training programs; and for the... and teachers who are located in rural areas; or connect teachers and students, located in one rural...

  15. Suicide announcement on Facebook.

    Science.gov (United States)

    Ruder, Thomas D; Hatch, Gary M; Ampanozi, Garyfalia; Thali, Michael J; Fischer, Nadja

    2011-01-01

    The media and the Internet may be having an influence on suicidal behavior. Online social networks such as Facebook represent a new facet of global information transfer. The impact of these online social networks on suicidal behavior has not yet been evaluated. To discuss potential effects of suicide notes on Facebook on suicide prevention and copycat suicides, and to create awareness among health care professionals. We present a case involving a suicide note on Facebook and discuss potential consequences of this phenomenon based on literature found searching PubMed and Google. There are numerous reports of suicide notes on Facebook in the popular press, but none in the professional literature. Online social network users attempted to prevent planned suicides in several reported cases. To date there is no documented evidence of a copycat suicide, directly emulating a suicide announced on Facebook. Suicide notes on online social networks may allow for suicide prevention via the immediate intervention of other network users. But it is not yet clear to what extent suicide notes on online social networks actually induce copycat suicides. These effects deserve future evaluation and research.

  16. Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor PAS-A Domain

    Science.gov (United States)

    Wu, Dalei; Potluri, Nalini; Kim, Youngchang

    2013-01-01

    The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that binds to xenobiotics and responds by regulating the expression of gene programs required for detoxification and metabolism. AHR and its heterodimerization partner aryl hydrocarbon receptor nuclear translocator (ARNT) belong to the basic helix-loop-helix (bHLH)–PER-ARNT-SIM (PAS) family of transcription factors. Here we report the 2.55-Å-resolution crystal structure of the mouse AHR PAS-A domain, which represents the first AHR-derived protein structure. The AHR PAS-A domain forms a helix-swapped homodimer in the crystal and also in solution. Through a detailed mutational analysis of all interface residues, we identified several hydrophobic residues that are important for AHR dimerization and function. Our crystallographic visualization of AHR PAS-A dimerization leads us to propose a mode of heterodimerization with ARNT that is supported by both biochemical and cell-based data. Our studies also highlight the residues of other mammalian bHLH-PAS proteins that are likely involved in their homo- or heterodimerization. PMID:24001774

  17. PAS kinase: a nutrient sensing regulator of glucose homeostasis.

    Science.gov (United States)

    DeMille, Desiree; Grose, Julianne H

    2013-11-01

    Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease. © 2013 International Union of Biochemistry and Molecular Biology.

  18. Editor's Comment and Announcement.

    Science.gov (United States)

    Bortolussi, Robert

    2017-12-17

    It is hard to believe but Clinical and Investigative Medicine (CIM), the official journal of Canadian Society for Clinical Investigation (CSCI), will soon celebrate its 40th birthday!  Over these past four decades, CIM has been the premier journal for Canadian clinician scientists; publishing over 1,000 articles on breakthroughs and major advances from Canada and around the world.  We are listed on Medline, PubMed and the Library of Science. We have been, and will continue to be, an independent journal. To celebrate this auspicious occasion, we have plans to become an even bigger showpiece for national and international clinical advances. We want to connect more closely with Canadian clinician scientists and trainees and we particularly want to encourage more Canadian publications. Changes will soon be coming to CIM with several new features: Newsletter with announcements and news on activities of interest to clinician scientists and trainees; Focused Reviews on specific areas of research; Reflections on work and life experiences of trainees and senior clinician scientists; Methods Papers describing novel methods anticipated to be useful for others; and  Guidelines or Recommendations on clinical care that are endorsed by a Canadian Medical or Surgical Society. Starting in 2018, we will be publishing on a quarterly basis. This will help to ensure we will focus on important breakthroughs and commentaries. However, we are also planning a special edition in the autumn to commemorate the 40th birthday. Stay tuned! Of course CIM will continue to publish original papers on discoveries in pathophysiology, prevention, management, treatment and outcome of clinical problems confronting clinicians in Canada and around the world.  Please join us as we embark on these changes and a new era for CIM, Robert Bortolussi Clinical and Investigative Medicine (CIM) Editor in Chief.

  19. PAs in primary care: Current status and workforce implications.

    Science.gov (United States)

    Coplan, Bettie; Smith, Noel; Cawley, James F

    2017-09-01

    Understanding the PA primary care workforce is an initial step toward greater use of primary care PAs in new healthcare delivery models. This study sought to describe primary care PA practice as it compares with PA practice in other specialties. Data from two 2015 national American Academy of Physician Assistants surveys were analyzed using descriptive statistics. Statistically significant differences between primary care and specialty PAs were assessed using tests of column proportions and tests of column means. Compared with PAs in specialties, primary care PAs were older, saw more patients per week, and spent less time consulting with physicians. In addition, higher percentages were Hispanic, had a record of military service, and had plans to leave their specialty or retire. Primary care PAs appear to possess unique strengths; however, challenges to maintaining a primary care PA workforce are substantial.

  20. Evaluating the lifestyles of physicians and PAs in orthopedics.

    Science.gov (United States)

    Shannon, Katherine M; Merenstein, Daniel J

    2017-01-01

    Limited current research is available comparing job satisfaction and lifestyles of physicians and physician assistants (PAs). Given the professional similarities and the upward trend in employment for both professions, this research is important in educating future professionals and employers. This study examined job contentment among orthopedic physicians and PAs. A cross-sectional survey was designed to assess career and lifestyle satisfaction. The survey was e-mailed to orthopedic clinics across the United States. 27 PAs and 50 physicians completed the survey. Compared with physicians, PAs were more likely to recommend their career and to desire to switch specialties. Physicians reported a higher level of agreement that the professional schedule overshadows personal life, and that the stress and demand of the profession impair personal health. PAs in orthopedics self-reported a higher lifestyle satisfaction than physicians. One specialty was examined and larger, more diverse studies should be conducted.

  1. Pasca-Islamisme dalam PAS: Analisis terhadap Kesan Tahalluf Siyasi

    Directory of Open Access Journals (Sweden)

    MUHAMMAD FAIZ MUKMIN ABDUL MUTALIB

    2015-12-01

    Full Text Available This study discusses the impact of post-Islamism in the Parti Islam Se-Malaysia (PAS, specifically on tahalluf siyasi (political alliance with Pakatan Rakyat (People Coalition. Post Islamism is a contemporary Islamist school of thought with regard to politics. The characteristics of post-Islamism such as toleration, participation and inclusivism has greatly influenced the modus operandi of the Islamic movement including PAS. Inclusiveness in post-Islamism had motivated PAS in having political coalition with more liberal parties such as Parti Keadilan Rakyat (PKR and Democratic Action Party (DAP. Post-Islamism as popularised by Asef Bayat was established on Western knowledge narratives, therefore such study as this should be done in order to recognise its negative impacts. To achieve this objective, the researchers used qualitative method through the process of collecting by scrutinising and analysing related data on the discourse of post-Islamism. The result of the study shows that PAS has been affected by the post-Islamism. The impact of post-Islamism in PAS however shows that PAS did not play dominant role in the Coalition throughout the political alliance. Besides, PAS also compromised a lot with its principles including its Islamic principles. Post-Islamism had also affected PAS in reducing the Muslims vote to PAS because of their support for DAP. This study therefore exposed the negative sides of post-Islamism to Islamic movement. With current development in PAS, it is hoped that this exposure will consult the Islamic movements in critically weighing their support to any kind of ideas particularly from the West.

  2. Return on investment of advanced practice medical degrees: NPs vs. PAs.

    Science.gov (United States)

    Craig, Christopher K; Holmes, James H; Carter, Jeffery E

    2017-06-01

    As the United States faces a predicted physician shortage over the next 2 decades, physician assistants (PAs) and NPs are expected to fill the void. At the same time, because education is expensive, student loan and tuition increases have many potential applicants assessing differences in reimbursement and wondering about their return on investment (ROI). An analysis compared PA and NP salaries by incorporating national salary data, federal income tax, and student loans for a comparative analysis of each career pathway. Salaries were abstracted from the 2012 Bureau of Labor Statistics database. The net present value (NPV) of PA and NP salaries was calculated with a 5% discount rate. Principal and interest for student loans was calculated at a 6% interest fixed-rate loan over 30 years. NPVs were then compared with projected ROI at retirement age. Relative career values were also given to each career choice, based on a retirement age of 65 years, which translates to about 41 years of employment for both PAs and NPs. PAs' and NPs' educational loans both equalled $129,484 on total repayment. The median annual salary of a PA was $90,930 and $89,960 for an NP. PA data yielded a 5% NPV of $781,323 compared with $764,348 for NPs. Of note, the 5% NPV of a 4-year nursing degree is $728,436. PAs have a slightly higher ROI compared with NPs. These findings may change due to adjustments in nursing training models. Many PA programs allow matriculation immediately after obtaining a bachelor's degree. NP schools often require nursing experience before entering their program. Some schools are considering an accelerated NP program, allowing immediate matriculation after obtaining a bachelor's degree. Because many NP programs have become doctoral degrees, the increased duration of training, higher tuition, and fewer years worked before retirement lower the overall NP ROI. A similar reduction in ROI was considered marginal in PAs who attend residency programs-though these programs are

  3. PAS3, a Saccharomyces cerevisiae Gene Encoding a Peroxisomal Integral Membrane Protein Essential for Peroxisome Biogenesis

    NARCIS (Netherlands)

    Höhfeld, Jörg; Veenhuis, Marten; Kunau, Wolf-H.

    Saccharomyces cerevisiae pas3-mutants are described which conform the pas-phenotype recently reported for the peroxisomal assembly mutants pas1-1 and pas2 (Erdmann, R., M. Veenhuis, D. Mertens, and W.-H Kunau. 1989. Proc. Natl. Acad. Sci. USA. 86:5419-5423). The isolation of pas3-mutants enabled us

  4. Is macroeconomic announcement news priced?

    NARCIS (Netherlands)

    de Goeij, Peter; Hu, Jiehui; Werker, Bas

    2016-01-01

    We test whether news contained in macroeconomic announcements (MEAs) is priced in the cross-section of stock returns. When including news on a set of widely followed individual macroeconomic fundamentals in the cross-section of stock returns, estimates of their prices of risk are consistent with the

  5. Successful oral desensitization to i.v. para-aminosalicylic acid (PAS) using encapsulated PAS dry substance.

    Science.gov (United States)

    Vesenbeckh, S M; Becker, J; Huhnt, C; Karras, B; Bauer, T T; Mauch, H; Rüssmann, H; Schönfeld, N

    2012-04-01

    para-Aminosalicylic acid (PAS) is commonly used in the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis. Since its first use in the 1940s, hypersensitivity reactions frequently limit its use in clinical practice. Cases of successful desensitization against PAS using orally administered ascending doses are described in the literature. A 25-year-old patient with severe pulmonary multidrug-resistant tuberculosis developed drug fever with rash, acral cyanosis, and shivering immediately after the intravenous application of PAS. Hard gelatine capsules containing PAS dry substance were prepared in order to desensitize this patient. Encapsulated PAS was applied orally in rising doses starting with 10 mg/day and doubling the dose every 2 days until the half-maximal dose of 5,120 mg was reached. Desensitization covers a period of 21 days. Subsequent intravenous application of PAS at the full dose was well tolerated. In a 12-month follow-up period, no more allergic reactions appeared. PAS dry substance encapsulated in hard gelatine capsules and administered orally in rising concentrations may be useful to archive a successful desensitization for subsequent intravenous applications.

  6. Histopathological examination of nail clippings using PAS staining (HPE-PAS): gold standard in diagnosis of Onychomycosis.

    Science.gov (United States)

    Jeelani, Shazia; Ahmed, Qazi Masood; Lanker, Audil Mohmad; Hassan, Iffat; Jeelani, Nasir; Fazili, Tawheeda

    2015-01-01

    Onychomycosis is fungal infection of one or more of the nail units. However, because fungi cause only about half of all nail dystrophies, the use of appropriate diagnostic techniques is important to ensure correct diagnosis and treatment. Aim of the present study was to compare direct microscopy, culture and HPE-PAS for diagnosis of onychomycosis by evaluating their sensitivity and various other relevant statistical parameters. A prospective, hospital-based, cross-sectional study was conducted on 216 patients with a high degree of clinical suspicion of onychomycosis. Nail specimens were evaluated using three diagnostic methods, i.e. direct microscopy using 20% Potassium hydroxide (KOH) & 40% Di-methyl-suphoxide (DMSO), culture and histopathological examination using PAS stain (HPE-PAS). Of 216 patients direct microscopy was positive in 138 (63.9%), culture in 147 (68%) and HPE-PAS in 164 patients (76%). One hundred and seventy-nine patients fitted into the criteria set for confirmed diagnosis of onychomycosis. Using this as a denominator; direct microscopy, culture and HPE-PAS had sensitivities of 77.1%, 70% and 91.6% respectively. Also, HPE-PAS showed the highest sensitivity of 94.7% in 19 cases with prediagnostic antimycotic treatment compared to direct microscopy (42.1%) or culture (57.9%). HPE-PAS shows high sensitivity for diagnosis of onychomycosis and can be considered as a gold standard in the diagnosis of onychomycosis. © 2014 Blackwell Verlag GmbH.

  7. News and Announcements

    Science.gov (United States)

    1999-07-01

    the inside of meteorites. Zare and colleague Andrew Alexander are contributors to the Journal's Viewpoints series, sponsored by the Camille and Henry Dreyfus Foundation: "Anatomy of Elementary Chemical Reactions", JCE, 1998, 75, 1105. The Welch Award in Chemistry has been given by the Welch Foundation since 1972 to honor lifetime achievements in the field. Zare will be honored and presented with a $300,000 prize and gold medallion during the Foundation's annual award banquet held in Houston in October. NEACT Conference: Chemistry of Materials and Material Science The 61st Summer Conference of NEACT, the New England Association of Chemistry Teachers, will be held from Monday, August 9, through Thursday, August 12, at Massachusetts Institute of Technology in Cambridge, MA. The four-day conference will feature an exploration of the chemistry of materials and material science and effective methods of presenting these in the classroom and laboratory. The keynote address is "Teaching Solid State Chemistry at MIT" by Ron Latanision of MIT's Department of Material Science. Other presentations include "Driving Force", James Livingston; "The Colorful Nanoworld", Moungi Bawendi; "Molecular Wire-Based Amplification in Chemical Sensors", Timothy Swager; "Putting Solids in the Foundation", Arthur Ellis, George Lisensky, and Karen Nordell; "Miracle Materials", Valerie Wilcox; "Teaching About Polymers to Chemistry Students", Richard Stein; and "Using Software in Teaching About Polymers to Chemistry Students", William Vining. There will be a selection of workshops on the conference theme as well. The conference is open to all. The program chairperson is Peter J. Nassiff, Science Department Chairperson at Burlington High School. For further information contact Nassiff at 80 Gregory Road, Framingham, MA 01701; email: pnassiff@massed.net. Call for Symposia, Papers, & Workshops: 16th BCCE The Web site for the 16th Biennial Conference on Chemical Education, July 30-August 3, 2000, at the

  8. The role of Atg29 phosphorylation in PAS assembly.

    Science.gov (United States)

    Mao, Kai; Chew, Leon H; Yip, Calvin K; Klionsky, Daniel J

    2013-12-01

    Macroautophagy (hereafter autophagy) initiates at the phagophore assembly site (PAS), where most of the AuTophaGy-related (Atg) proteins are at least transiently localized. As the first protein complex targeted to the PAS, the Atg17-Atg31-Atg29 complex serves as the scaffold for other Atg proteins and plays a critical role for the organization of the PAS, and in autophagy initiation. We recently showed that this complex is constitutively formed and activated by the phosphorylation of Atg29 when autophagy is induced. Phosphorylation of Atg29 is required for its interaction with Atg11, another scaffold protein, and its function for promoting the proper assembly of the PAS. Single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends. This structural arrangement allows Atg29 to interact with Atg11, and is critical in the organization of the intact Atg1 complex.

  9. Space Launch System (SLS) Program Overview NASA Research Announcement (NRA) Advanced Booster (AB) Engineering Demonstration and Risk Reduction (EDRR) Industry Day

    Science.gov (United States)

    May, Todd A.

    2011-01-01

    SLS is a national capability that empowers entirely new exploration for missions of national importance. Program key tenets are safety, affordability, and sustainability. SLS builds on a solid foundation of experience and current capacities to enable a timely initial capability and evolve to a flexible heavy-lift capability through competitive opportunities: (1) Reduce risks leading to an affordable Advanced Booster that meets the evolved capabilities of SLS (2) Enable competition by mitigating targeted Advanced Booster risks to enhance SLS affordability and performance The road ahead promises to be an exciting journey for present and future generations, and we look forward to working with you to continue America fs space exploration.

  10. 20 CFR 615.13 - Announcement of the beginning and ending of Extended Benefit Periods.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Announcement of the beginning and ending of Extended Benefit Periods. 615.13 Section 615.13 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR EXTENDED BENEFITS IN THE FEDERAL-STATE UNEMPLOYMENT COMPENSATION PROGRAM § 615.13 Announcement of the beginning and ending...

  11. 77 FR 59986 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in New...

    Science.gov (United States)

    2012-10-01

    ... Employment and Training Administration Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in New York in the Emergency Unemployment Compensation 2008 (EUC08) Program and the...: Notice. SUMMARY: Announcement regarding a change in eligibility for Unemployment Insurance (UI) claimants...

  12. 76 FR 30369 - Announcement of the Award of a Replacement Grant

    Science.gov (United States)

    2011-05-25

    ... CONTACT: Thom Campbell, Program Manager, Office of Community Services, 901 D Street, SW., Washington, DC... Announcement of the Award of a Replacement Grant AGENCY: Office of Community Services (OCS), ACF, DHHS. ACTION: Announcement of the award of a replacement grant from the Office of Community Services to Humboldt State...

  13. Structural characterization of mammalian bHLH-PAS transcription factors.

    Science.gov (United States)

    Wu, Dalei; Rastinejad, Fraydoon

    2017-04-01

    The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1. Most bHLH-PAS proteins have been genetically linked to variety of diseases in humans, including cancers, metabolic syndromes and psychiatric conditions. To function as transcription factors, the bHLH-PAS proteins must form heterodimeric complexes. Recent crystallographic studies of HIF-α-ARNT and CLOCK-BMAL1 complexes have unveiled the organization of their multi-domain bHLH-PAS-A-PAS-B segments, revealing how these architectures can give rise to unique patterns of heterodimerization. As our structural understanding becomes better integrated with ligand-discovery and target gene identification, a more comprehensive picture of their architectural and functional properties will emerge. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. 7 CFR 29.80 - Announcing grades.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Announcing grades. 29.80 Section 29.80 Agriculture... INSPECTION Regulations Mandatory Inspection § 29.80 Announcing grades. The grade of each lot of tobacco as... waive the requirement of announcing grades in the auction if he finds it impractical for the...

  15. IBM announces global Grid computing solutions for banking, financial markets

    CERN Multimedia

    2003-01-01

    "IBM has announced a series of Grid projects around the world as part of its Grid computing program. They include IBM new Grid-based product offerings with business intelligence software provider SAS and other partners that address the computer-intensive needs of the banking and financial markets industry (1 page)."

  16. 76 FR 39880 - Announcement of a Grant Award

    Science.gov (United States)

    2011-07-07

    ... FURTHER INFORMATION CONTACT: James Gatz, Program Manager, Assets for Independence, Office of Community... Community Services, ACF, HHS. ACTION: Announcement of the Award of an Assets for Independence Grant to the... Assets for Independence Act in Title IV of the Community Opportunities, Accountability, and Training and...

  17. Does timing and announcement matter?

    DEFF Research Database (Denmark)

    Adams, Philip D; Andersen, Lill Thanning; Jacobsen, Lars Bo

    We address the issue of timing and announcement within a dynamic applied general equilibrium model of the Danish economy. Specifically we analyse the introduction of a quota on the production of pigs. Two scenarios are analysed, namely the introduction of a once-off quota without any previous...... to the method of implementation. In the long run we find that the alternative timing strategies lead to similar results....

  18. Structural properties of PAS domains from the KCNH potassium channels.

    Science.gov (United States)

    Adaixo, Ricardo; Harley, Carol A; Castro-Rodrigues, Artur F; Morais-Cabral, João H

    2013-01-01

    KCNH channels form an important family of voltage gated potassium channels. These channels include a N-terminal Per-Arnt-Sim (PAS) domain with unknown function. In other proteins PAS domains are implicated in cellular responses to environmental queues through small molecule binding or involvement in signaling cascades. To better understand their role we characterized the structural properties of several channel PAS domains. We determined high resolution structures of PAS domains from the mouse EAG (mEAG), drosophila ELK (dELK) and human ERG (hERG) channels and also of the hERG domain without the first nine amino acids. We analyzed these structures for features connected to ligand binding and signaling in other PAS domains. In particular, we have found cavities in the hERG and mEAG structures that share similarities with the ligand binding sites from other PAS domains. These cavities are lined by polar and apolar chemical groups and display potential flexibility in their volume. We have also found that the hydrophobic patch on the domain β-sheet is a conserved feature and appears to drive the formation of protein-protein contacts. In addition, the structures of the dELK domain and of the truncated hERG domain revealed the presence of N-terminal helices. These helices are equivalent to the helix described in the hERG NMR structures and are known to be important for channel function. Overall, these channel domains retain many of the PAS domain characteristics known to be important for cell signaling.

  19. Un petit chemin qui ne sent pas la noisette!

    CERN Multimedia

    2006-01-01

    Travelling gypsies settle very often in Echevenex. Due to the lack of toilettes, they use a nice shaded path to make their bodily needs... Sanitary problems appeared and the inhabitants of Echenevex announce their anger

  20. ProPAS: standalone software to analyze protein properties.

    Science.gov (United States)

    Wu, Songfeng; Zhu, Yunping

    2012-01-01

    Physicochemical properties of proteins/peptides are often used to separate proteins/peptides from complex biological samples in proteomics research, which is necessary for the further proteins/peptides identification. So, the analyses of these properties are very important for the design of proteomic experiments and the further analyses of identified results. Current available web-based tools are difficult to analyze large-scale datasets. Here we provide a standalone software ProPAS (Protein Properties Analyses Software) to calculate these properties in local computers. ProPAS could be used to calculate several physicochemical parameters of proteins/peptides, including the isoelectric point (pI), hydrophobicity (Hy) and mass weight (MW). Additionally, ProPAS provides the statistic results to get the number distribution along the parameter values. The results could be copied to other software such as Excel to get the distribution chart. The amino acid composition of all the input proteins/peptides could also be calculated from all input sequences. Detail description, updates and download link for ProPAS could be found at the website of http://bioinfo.hupo.org.cn/tools/ProPAS/propas.htm.

  1. PAS or plasma for storage of platelets? A concise review.

    Science.gov (United States)

    van der Meer, P F

    2016-10-01

    Platelet additive solutions (PASs) are becoming increasingly popular for storage of platelets, and PAS is steadily replacing plasma as the storage medium of platelets. PASs are electrolyte solutions intended for storage of platelets, and they are used to modulate the quality of the platelets by adding specific ingredients. All currently available PASs contain acetate. Acetate reduces the amount of glucose that is oxidised into lactic acid and thereby prevents the lowering of pH, which decreases platelet quality. Furthermore, the oxidation of acetate leads to the production of bicarbonate, which serves as buffer. The presence of potassium and magnesium in PAS prevents the lowering of pH and reduces the degree of spontaneous activation of the platelets during storage. In the hospital, platelets stored in PAS result in about half of the number of allergic transfusion reactions as compared with platelets in plasma. Recovery and survival after transfusion, as well as corrected count increments, are at least as good for platelets in PAS as for plasma, and recent data suggest they may even be better. Therefore, with the current generation of PASs, PAS should be preferred over the use of plasma for the storage of platelet concentrates. © 2016 British Blood Transfusion Society.

  2. Announcements

    NARCIS (Netherlands)

    NN,

    1998-01-01

    Dr. B.C. Tan at the National University of Singapore (SINU) is looking for good and enthusiastic graduate students, especially from ASEAN countries, to study bryophyte systematics for either a MSc or a PhD degree. SINU has good laboratory and library facilities for both classical and modern

  3. 78 FR 25756 - Announcement of Funding Awards for Office of Healthy Homes and Lead Hazard Control (OHHLHC) Grant...

    Science.gov (United States)

    2013-05-02

    ...] Announcement of Funding Awards for Office of Healthy Homes and Lead Hazard Control (OHHLHC) Grant Programs for...: Office of Healthy Homes and Lead Hazard Control, HUD. ACTION: Announcement of funding awards. SUMMARY: In... funding under the Office of Healthy Homes and Lead Hazard Control (OHHLHC) Grant Program Notices of...

  4. Extravehicular Activity (EVA) Power, Avionics, and Software (PAS) 101

    Science.gov (United States)

    Irimies, David

    2011-01-01

    EVA systems consist of a spacesuit or garment, a PLSS, a PAS system, and spacesuit interface hardware. The PAS system is responsible for providing power for the suit, communication of several types of data between the suit and other mission assets, avionics hardware to perform numerous data display and processing functions, and information systems that provide crewmembers data to perform their tasks with more autonomy and efficiency. Irimies discussed how technology development efforts have advanced the state-of-the-art in these areas and shared technology development challenges.

  5. La question pas si bête. Pourquoi les enfants n'aiment pas les légumes ?

    OpenAIRE

    2017-01-01

    Un gratin de salsifis, des endives rôties ou de bons épinards… Beaucoup de plats à base de légumes n’enchantent pas nos chères petites têtes blondes. Caprice ou réflexe ? Pourquoi les enfants rechignent-ils tant à manger des légumes ? Choux de Bruxelles, salsifis, endives… Faire manger des légumes aux enfants, c’est parfois compliqué. Pourtant, si les enfants ne sont pas fans des légumes du marché, ce n’est pas (seulement) pour faire tourner leurs parents en bourrique. Il s’agit même d’un...

  6. Ceux-ci ne sont pas : [luuletused] / Kalju Kruusa

    Index Scriptorium Estoniae

    Kruusa, Kalju, pseud., 1973-

    2003-01-01

    Sisu: Ceux-ci ne sont pas ; Köögivahet ; "Taara..." ; "Pakane pistab pisikesi ..." ; "Meri on kaet mattklaasiga ; Pydemise päivil ; "Toas muusika mängib ..." ; "Jäin juustu imetlema ; "Mu elu on mustikas ..." ; Hingepidetus ; ŁNo me gusta la cocina

  7. The PAS fold: A redefinition of the PAS domain based upon structural prediction. A large-scale homology modelling study

    NARCIS (Netherlands)

    Hefti, M.H.; Francoijs, C.J.J.; Vries, de S.C.; Dixon, R.; Vervoort, J.J.M.

    2004-01-01

    In the postgenomic era it is essential that protein sequences are annotated correctly in order to help in the assignment of their putative functions. Over 1300 proteins in current protein sequence databases are predicted to contain a PAS domain based upon amino acid sequence alignments. One of the

  8. Modified PAS stain: A new diagnostic method for onychomycosis.

    Science.gov (United States)

    Hajar, Tamar; Fernández-Martínez, Ramon; Moreno-Coutiño, Gabriela; Vásquez Del Mercado, Elsa; Arenas, Roberto

    2016-01-01

    Onychomycosis is the most common nail disease and represents around 50% of nail disorders. Accurate diagnosis with adequate evidence is ideal before starting any treatment. Current diagnostic methods offer low specificity and sensitivity. To create a new method for the diagnosis of onychomycosis, and to compare its sensitivity and specificity with the existing methods. One hundred and ninety-two samples with clinical suspicion of onychomycosis were included and underwent modified PAS stain (M-PAS), KOH/chlorazol black (KOH/CB) and culture testing. Sensitivity, specificity, positive and negative predictive values were calculated. In 152 out of 192 samples (79.2%) fungi structures were found in at least one of the three tests performed, and the patients were diagnosed with onychomycosis; 40 samples out of 192 (20.8%) were negative. Using M-PAS, filaments and/or spores were seen in 143 samples from the 152 positive (94%); 39 of them were negative to KOH/CB and positive to M-PAS (25.6%). With KOH/CB, filaments and/or spores were seen in 113 cases from the 152 positive samples (73.8% of the onychomycosis cases). Thirty-five cultures were positive, of which 77% were identified as Trichophyton rubrum; 117 onychomycosis cases were diagnosed despite the negative culture (76.9%). M-PAS showed 92.5% sensitivity and 55.55% specificity, a 67.5% positive predictive value and a 81.6% negative productive value. This procedure, a combination of the existing methods to diagnose onychomycosis, KOH/CB together with a nail clipping biopsy, proved to have high sensitivity, as well as being rapid, easy, inexpensive and readily available in most hospital settings. M-PAS allowed us to diagnose 39 cases (25.6% of the cases of onychomycosis) that were false negative using only KOH/CB and culture. Copyright © 2014 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

  9. Hans sidste ønske var et pas

    DEFF Research Database (Denmark)

    Sodemann, Morten

    2014-01-01

    Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk......Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk...

  10. Hans sidste ønske var et dansk pas

    DEFF Research Database (Denmark)

    Sodemann, Morten

    2014-01-01

    Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk......Selv med svære sygdomme, bunker af lægeerklæringer, ekspertvurderinger og værdig stædighed opnår flygtninge ikke at få et dansk pas. Justitsministeriet bagatelliserer lægernes oplysninger og holder ansøgere hen med ligegyldigheder, indtil de dør åndeligt eller fysisk...

  11. 75 FR 38145 - Announcing the New National Electronic Job Registry for Use in the H-2A Temporary Agricultural...

    Science.gov (United States)

    2010-07-01

    ... Employment and Training Administration Announcing the New National Electronic Job Registry for Use in the H-2A Temporary Agricultural Labor Certification Program AGENCY: Employment and Training Administration, Department of Labor. ACTION: Notice. SUMMARY: The Employment and Training Administration (ETA) is announcing...

  12. Twitter sentiment around the Earnings Announcement events.

    Science.gov (United States)

    Gabrovšek, Peter; Aleksovski, Darko; Mozetič, Igor; Grčar, Miha

    2017-01-01

    We investigate the relationship between social media, Twitter in particular, and stock market. We provide an in-depth analysis of the Twitter volume and sentiment about the 30 companies in the Dow Jones Industrial Average index, over a period of three years. We focus on Earnings Announcements and show that there is a considerable difference with respect to when the announcements are made: before the market opens or after the market closes. The two different timings of the Earnings Announcements were already investigated in the financial literature, but not yet in the social media. We analyze the differences in terms of the Twitter volumes, cumulative abnormal returns, trade returns, and earnings surprises. We report mixed results. On the one hand, we show that the Twitter sentiment (the collective opinion of the users) on the day of the announcement very well reflects the stock moves on the same day. We demonstrate this by applying the event study methodology, where the polarity of the Earnings Announcements is computed from the Twitter sentiment. Cumulative abnormal returns are high (2-4%) and statistically significant. On the other hand, we find only weak predictive power of the Twitter sentiment one day in advance. It turns out that it is important how to account for the announcements made after the market closes. These after-hours announcements draw high Twitter activity immediately, but volume and price changes in trading are observed only on the next day. On the day before the announcements, the Twitter volume is low, and the sentiment has very weak predictive power. A useful lesson learned is the importance of the proper alignment between the announcements, trading and Twitter data.

  13. CMS announces new payment model

    Directory of Open Access Journals (Sweden)

    Robbins RA

    2018-01-01

    Full Text Available No abstract available. Article truncated after 150 words. On Tuesday, 1/9/18, the Centers for Medicare and Medicaid (CMS announced a new voluntary bundled-payment model that will be considered an advanced alternative payment model under Medicare Access and CHIP Reauthorization Act of 2015 (MACRA (1. The new model is the first advanced Alternative Payment Model (APM to be introduced by the Trump administration. The Trump administration has been a vocal advocate of reducing administrative burden for clinicians and has touted voluntary models as a solution (2. The new, voluntary model comes less than two months after the CMS officially decided to eliminate two mandatory bundled-payment models created during the Obama administration. Under the model, clinician payment will be based on quality measures during a 90-day episode of care. Participants must select at least one of the 32 clinical episodes to apply to the model. The inpatient clinical episodes are listed in Table 1 (3. Table 1. Clinical inpatient episodes under …

  14. Start-up date announced

    CERN Multimedia

    7th August 2008. CERN has announced that the first attempt to circulate the beam in the LHC will be made on the 10th September. This news comes as the cool down phase of commissioning the accelerator reaches a successful conclusion.The next phase is the synchronization of the LHC with the SPS accelerator, the last link in the LHC’s injector chain. A first synchronization test is scheduled for the 9th August, for the clockwise circulating beam, with the second to follow over the coming weeks.Once stable circulating beams have been established in September they will be brought to collision, and the final step will be to commission the LHC’s acceleration system to boost the energy to 5 TeV, the target energy for 2008.“We’re finishing a marathon with a sprint”, said LHC project leader Lyn Evans. “It’s been a long haul, and we’re all eager to get the LHC research programme underway.”For more information, please see the recent press release at: http://press.web.cern.ch/press/PressReleases/Rele...

  15. 32 CFR 806b.11 - When to give Privacy Act Statements (PAS).

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false When to give Privacy Act Statements (PAS). 806b.11 Section 806b.11 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE... (PAS). (a) Give a PAS orally or in writing to the subject of the record when you are collecting...

  16. USAJOBS Job Opportunity Announcements (JOA) SOAP API

    Data.gov (United States)

    Office of Personnel Management — The purpose of the SOAP based API is to provide the full Federal Job Opportunity Announcement (JOA) content to the consumer. It is anticipated that this API will be...

  17. New Michigan Tiny House Community Announced

    National Research Council Canada - National Science Library

    Michael Chamernik

    2016-01-01

      A new tiny house community called Tiny House Estates has been announced and will be located at the northern end of Michigan's Lower Peninsula, at Traverse Bay Resort in Traverse City, near the shores of Lake Michigan...

  18. USAJOBS Job Opportunity Announcements (JOA) REST API

    Data.gov (United States)

    Office of Personnel Management — This REST-based API is designed to support lightweight Federal Job Opportunity Announcement (JOA) content consumption by consumers. It is anticipated that this API...

  19. Television as Textbook: "Cuéntame cómo pasó" in the Spanish (Literature) Classroom

    Science.gov (United States)

    Bartlett, Linda; Manyé, Lourdes

    2015-01-01

    The long-running Spanish television program "Cuéntame cómo pasó" represents not only a wildly successful series for Radio Televisión Española, but also an excellent example of the project of historical memory. Premiering in 2001 (but set, in the first season, in 1968), the story of the multigenerational Alcántara family forms a…

  20. A novel application of periodic acid-Schiff (PAS) staining and fluorescence imaging for analysing tapetum and microspore development.

    Science.gov (United States)

    Chawla, Mrinalini; Verma, Vibha; Kapoor, Meenu; Kapoor, Sanjay

    2017-01-01

    The precisely timed process of tapetum development and its degradation involving programmed cell death is an important molecular event during anther development. Through its degeneration, the tapetum not only provides nutritive substances to the developing microspores but also contributes to the pollen wall by way of sporopollenin, which is a complex mixture of biopolymers, containing long-chain fatty acids, phenylpropanoids, phenolics and traces of carotenoids. A number of dyes and staining methods have been used to visualize tapetal structure and its components by using light microscopy techniques, but none of these methods could differentially stain and thus distinguish tapetal cells from other cell types of anther wall. While analysing progression of tapetum development in different cell types in rice anthers, we discovered a unique property of periodic acid-Schiff (PAS) stain, which upon interaction with some specific component(s) in tapetal cells and developing microspores emits fluorescence at ~620 nm. In rice anthers, the PAS-associated fluorescence could be observed initially in tapetum and developing microspores, and subsequent to degeneration of tapetum, the fluorescence was found to emanate mainly from the pollen wall. We also show that PAS-dependent fluorescence in tapetal cells is distinct from the autofluorescence resulting from pollen wall components and is also not caused by interaction of PAS with pollen starch. Henceforth, this novel fluorescence property of PAS stain could prove to be a new tool in the toolkit of developmental biologists to analyse different aspects of tapetum development and its degeneration with little more ease and specificity.

  1. Delineating PAS-HAMP interaction surfaces and signalling-associated changes in the aerotaxis receptor Aer.

    Science.gov (United States)

    Garcia, Darysbel; Watts, Kylie J; Johnson, Mark S; Taylor, Barry L

    2016-04-01

    The Escherichia coli aerotaxis receptor, Aer, monitors cellular oxygen and redox potential via FAD bound to a cytosolic PAS domain. Here, we show that Aer-PAS controls aerotaxis through direct, lateral interactions with a HAMP domain. This contrasts with most chemoreceptors where signals propagate along the protein backbone from an N-terminal sensor to HAMP. We mapped the interaction surfaces of the Aer PAS, HAMP and proximal signalling domains in the kinase-off state by probing the solvent accessibility of 129 cysteine substitutions. Inaccessible PAS-HAMP surfaces overlapped with a cluster of PAS kinase-on lesions and with cysteine substitutions that crosslinked the PAS β-scaffold to the HAMP AS-2 helix. A refined Aer PAS-HAMP interaction model is presented. Compared to the kinase-off state, the kinase-on state increased the accessibility of HAMP residues (apparently relaxing PAS-HAMP interactions), but decreased the accessibility of proximal signalling domain residues. These data are consistent with an alternating static-dynamic model in which oxidized Aer-PAS interacts directly with HAMP AS-2, enforcing a static HAMP domain that in turn promotes a dynamic proximal signalling domain, resulting in a kinase-off output. When PAS-FAD is reduced, PAS interaction with HAMP is relaxed and a dynamic HAMP and static proximal signalling domain convey a kinase-on output. © 2015 John Wiley & Sons Ltd.

  2. Influence of PAS domain flanking regions on oligomerisation and redox signalling by NifL.

    Directory of Open Access Journals (Sweden)

    Richard Little

    Full Text Available Per-ARNT-Sim (PAS domains constitute a typically dimeric, conserved α/β tertiary fold of approximately 110 amino acids that perform signalling roles in diverse proteins from all kingdoms of life. The amino terminal PAS1 domain of NifL from Azotobacter vinelandii accommodates a redox-active FAD group; elevation of cytosolic oxygen concentrations result in FAD oxidation and a concomitant conformational re-arrangement that is relayed via a short downstream linker to a second PAS domain, PAS2. At PAS2, the signal is amplified and passed on to effector domains generating the 'on' (inhibitory state of the protein. Although the crystal structure of oxidised PAS1 reveals regions that contribute to the dimerisation interface, 21 amino acids at the extreme N-terminus of NifL, are unresolved. Furthermore, the structure and function of the linker between the two PAS domains has not been determined. In this study we have investigated the importance to signalling of residues extending beyond the core PAS fold. Our results implicate the N-terminus of PAS1 and the helical linker connecting the two PAS domains in redox signal transduction and demonstrate a role for these flanking regions in controlling the oligomerisation state of PAS1 in solution.

  3. Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides.

    Science.gov (United States)

    Heintz, Udo; Meinhart, Anton; Winkler, Andreas

    2014-03-01

    Per-ARNT-Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteins are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix-turn-helix DNA-binding motif. Here, crystal structures of two N-terminally and C-terminally truncated PpsR variants that comprise a single (PpsRQ-PAS1) and two (PpsRN-Q-PAS1) PAS domains, respectively, are presented and the multi-step strategy required for the phasing of a triple PAS domain construct (PpsRΔHTH) is illustrated. While parts of the biologically relevant dimerization interface can already be observed in the two shorter constructs, the PpsRΔHTH structure reveals how three PAS domains enable the formation of multiple oligomeric states (dimer, tetramer and octamer), highlighting that not only the PAS cores but also their α-helical extensions are essential for protein oligomerization. The results demonstrate that the long helical glutamine-rich linker of PpsR results from a direct fusion of the N-cap of the PAS1 domain with the C-terminal extension of the N-domain that plays an important role in signal transduction.

  4. 78 FR 37227 - Announcement of the Award of Single-Source Expansion Supplement Grants to Eight Personal...

    Science.gov (United States)

    2013-06-20

    ... following PREIS grantees: ] Supplement Grantee organization City State award amount Children's Hospital Los... HUMAN SERVICES Administration for Children and Families Announcement of the Award of Single-Source Expansion Supplement Grants to Eight Personal Responsibility Education Program Innovative Strategies (PREIS...

  5. 75 FR 74678 - Bureau for Democracy, Conflict and Humanitarian Assistance; Office of Food for Peace Announcement...

    Science.gov (United States)

    2010-12-01

    ... of Food for Peace Announcement of Request for Applications for Title II Non-Emergency Food Aid Programs; Notice Pursuant to the Food for Peace Act of 2008, notice is hereby given that the Request for... Aid Programs will be available via the Food for Peace Web site: http://www.usaid.gov/our_work...

  6. 76 FR 59718 - Announcement of Funding Awards Capital Fund Education and Training Community Facilities (CFCF...

    Science.gov (United States)

    2011-09-27

    ... URBAN DEVELOPMENT Announcement of Funding Awards Capital Fund Education and Training Community Facilities (CFCF) Program Fiscal Year 2010 AGENCY: Office of Public and Indian Housing, HUD. ACTION... INFORMATION: The CFCF program provides grants to Public Housing Agencies (PHAs) to develop facilities to...

  7. PAs in the ED: do physicians think they increase the malpractice risk?

    Science.gov (United States)

    Gifford, Alisa; Hyde, Mark; Stoehr, James D

    2011-06-01

    This study evaluates emergency physicians' perceptions of the malpractice risk posed by utilization of physician assistants (PAs) in emergency departments (EDs) in 2004 and again in 2009. A 16-question survey was mailed to a random sample of 1,000 active members of the American College of Emergency Physicians in 2004 and again in 2009. In both 2004 and 2009, 70% of the emergency physicians did not believe that PAs, when properly supervised, are more likely to commit malpractice than any other clinician. In both surveys, 80% of the respondents did not believe PAs were more likely to be sued for malpractice. A significant negative correlation was found between perceived risk of malpractice by PAs and the number of years physicians had worked with PAs or had worked in emergency medicine. From 2004 to 2009, the number of respondents practicing with PAs increased by 26%, the number directly supervising a PA in the ED increased by 19%, the number who thought PAs decreased patient wait times increased by 13%, and the number who reported that PAs increased patient satisfaction increased by 10%. As physicians gain clinical experience with PAs, their perceived risk of malpractice tends to decrease. These results may have implications for the utilization of PAs, particularly as EDs become more utilized for noncritical situations.

  8. A history of PAs in the US Public Health Service.

    Science.gov (United States)

    McKinnon, Mark F; Elizondo, Epifanio; Bonfiglio, Susan M; Hunter-Buskey, Robin N; Placide, Frances P; Bunnell, Rebecca A

    2016-12-01

    Since 1798, the men and women of the Commissioned Corps of the US Public Health Service (USPHS), one of the seven US uniformed services, have served on the front lines of public health. Two hundred years after the start of the USPHS, the first physician assistant (PA) entered the service to carry on the tradition of protecting, promoting, and advancing the health and safety of the nation. These dedicated clinicians are involved in healthcare delivery to underserved and vulnerable populations, disease control and prevention, biomedical research, food and drug regulation, and national and international response efforts for natural and man-made disasters. This article describes how PAs in the Commissioned Corps of the USPHS have impacted the health and safety of not only the United States but also the international community.

  9. Die dramatiese discours in Pas de deux van Hugo Claus

    Directory of Open Access Journals (Sweden)

    R. Vaughan

    1990-05-01

    Full Text Available Drama is action, verbal drama is speech action, and the dramatic text is subject to a similar set of rules as that governing the extra-literary communication situation. Dramatic irony, the very essence of drama itself, is generated by a dual, mutually interactive process of communication, whereby the audience is “written into” the text in a way distinguishing it from other literary genres, and by a systematic flouting of the rules governing communication. Pas de deux demonstrates the peculiar duality of dramatic discourse by its complex exploitation of the breakdown/non-breakdown of Grice’s Co-operative Principle-. communication/non-communication becomes reversible and, therefore, mutually constitutive concepts “releasing meaning” and conveying the “ideology” of this play.

  10. Les sciences cognitives ne sont pas des sciences humaines

    Directory of Open Access Journals (Sweden)

    Albert Ogien

    2011-10-01

    Full Text Available Cet article analyse les limites du naturalisme social que Laurence Kaufman et Laurent Cordonier proposent d’adopter dans cette même revue, en critiquant leur plaidoyer pour l’intégration des savoirs des sciences cognitives et des sciences humaines et sociales. Cette critique repose sur la réfutation de trois idées soutenues par les auteurs : 1 la description scientifique des mécanismes cognitifs élémentaires fournit une explication causale des conduites sociales qui doit se substituer à celles des sciences humaines et sociales ; 2 le recours au naturalisme permet de falsifier les préconceptions que ces dernières continuent à entretenir ; 3 le programme de naturalisation de l’esprit n’implique aucune forme de réductionnisme. Cette triple critique permet de rejeter leur appel en faveur d’un modèle intégré de la conduite humaine, en avançant un constat : dans la mesure où on ne sait pas comment combler le hiatus qui sépare les descriptions détaillées du cerveau au travail de l’explication des conduites des individus et de la manière dont ils en assurent la coordination dans le temps même où ils agissent en commun, les sciences humaines et sociales ont peu de choses à aller glaner du côté des sciences cognitives pour améliorer la manière dont elles analysent l’action. C’est que le travail de celles-ci se situe soit au niveau infra-humain du fonctionnement moléculaire, soit au niveau supra-humain de l’évolution ; et que seules les sciences humaines et sociales placent leurs analyses à un niveau simplement humain, en faisant des individus tels qu’ils vivent ensemble la mesure de toutes les choses qui les concernent. Ce qu’elles ne peuvent faire sur un mode naturaliste.Cognitive sciences are not social sciencesThis article examines the limits of the social naturalism proposed by Laurence Kauffman and Laurent Cordonier in this journal by criticizing their plea concerning knowledge integration of

  11. Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides

    Energy Technology Data Exchange (ETDEWEB)

    Heintz, Udo; Meinhart, Anton; Winkler, Andreas, E-mail: andreas.winkler@mpimf-heidelberg.mpg.de [Max Planck Institute for Medical Research, Heidelberg (Germany)

    2014-03-01

    Crystal structures of two truncated variants of the transcription factor PpsR from R. sphaeroides are presented that enabled the phasing of a triple PAS domain construct. Together, these structures reveal the importance of α-helical PAS extensions for multi-PAS domain-mediated protein oligomerization and function. Per–ARNT–Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few structures of multi-PAS proteins are known. Therefore, the molecular mechanism of multi-PAS domain-mediated protein oligomerization and function is poorly understood. The transcription factor PpsR from Rhodobacter sphaeroides is such a multi-PAS domain protein that, in addition to its three PAS domains, contains a glutamine-rich linker and a C-terminal helix–turn–helix DNA-binding motif. Here, crystal structures of two N-terminally and C-terminally truncated PpsR variants that comprise a single (PpsR{sub Q-PAS1}) and two (PpsR{sub N-Q-PAS1}) PAS domains, respectively, are presented and the multi-step strategy required for the phasing of a triple PAS domain construct (PpsR{sub ΔHTH}) is illustrated. While parts of the biologically relevant dimerization interface can already be observed in the two shorter constructs, the PpsR{sub ΔHTH} structure reveals how three PAS domains enable the formation of multiple oligomeric states (dimer, tetramer and octamer), highlighting that not only the PAS cores but also their α-helical extensions are essential for protein oligomerization. The results demonstrate that the long helical glutamine-rich linker of PpsR results from a direct fusion of the N-cap of the PAS1 domain with the C-terminal extension of the N-domain that

  12. Factor structure of the PAS-ADD Checklist with adults with intellectual disabilities.

    OpenAIRE

    Hatton, Chris; Taylor, John

    2008-01-01

    BACKGROUND: The PAS-ADD Checklist is designed to screen for likely mental health problems in people with intellectual disabilities (ID). The specificity of recommended subscales derived from diagnostic criteria is unclear. This paper therefore investigates the factor structure of the PAS-ADD Checklist to determine the adequacy of empirically derived subscales. \\ud METHOD: A total of 1,115 informants who had known service users for a median of 24 months completed the PAS-ADD Checklist on 1,155...

  13. Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA.

    Science.gov (United States)

    Winnen, Brit; Anderson, Eric; Cole, James L; King, Glenn F; Rowland, Susan L

    2013-05-01

    Histidine kinases are sophisticated molecular sensors that are used by bacteria to detect and respond to a multitude of environmental signals. KinA is the major histidine kinase required for initiation of sporulation upon nutrient deprivation in Bacillus subtilis. KinA has a large N-terminal region (residues 1 to 382) that is uniquely composed of three tandem Per-ARNT-Sim (PAS) domains that have been proposed to constitute a sensor module. To further enhance our understanding of this "sensor" region, we defined the boundaries that give rise to the minimal autonomously folded PAS domains and analyzed their homo- and heteroassociation properties using analytical ultracentrifugation, nuclear magnetic resonance (NMR) spectroscopy, and multiangle laser light scattering. We show that PAS(A) self-associates very weakly, while PAS(C) is primarily a monomer. In contrast, PAS(B) forms a stable dimer (K(d) [dissociation constant] of PAS domains revealed a critical role for PAS(B), but not PAS(A), in autophosphorylation of KinA. Our findings suggest that dimerization of PAS(B) is important for keeping the catalytic domain of KinA in a functional conformation. We use this information to propose a model for the structure of the N-terminal sensor module of KinA.

  14. Information and Announcements The Breakthrough Prize

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 10. Breakthrough Prize. B Sury Rajaram Nityananda Dipshikha Chakravortty. Information and Announcements Volume 19 Issue 10 October 2014 pp 966-969. Fulltext. Click here to view fulltext PDF. Permanent link:

  15. 76 FR 16630 - Announcement of an Award

    Science.gov (United States)

    2011-03-24

    ... Assistant Secretary and Inter-Departmental Liaison for Early Childhood Development announces the award of a..., Senior Policy Advisor for Early Childhood Health and Development, Office of the Deputy Assistant Secretary and Inter-Departmental Liaison for Early Childhood Development, 901 D Street, SW., Washington, DC...

  16. Information and Announcements Indian Academy of Sciences ...

    Indian Academy of Sciences (India)

    Information and Announcements. REFRESHER COURSE IN THEORETICAL PHYSICS sponsored by. Indian Academy of Sciences, Bangalore. A Refresher Course in Theoretical Physics, for College/University teachers, will be held at the Department of Physics, Bishop Moore. College, Mavelikara, Kerala during Novem-.

  17. 48 CFR 5.303 - Announcement of contract awards.

    Science.gov (United States)

    2010-10-01

    ... which synopsis was exempted under 5.202(a)(1). (b) Local announcement. Agencies may also release information on contract awards to the local press or other media. When local announcements are made for...

  18. 78 FR 34979 - Announcement of Grant Application Deadlines

    Science.gov (United States)

    2013-06-11

    ... and business customers located within the Proposed Funded Service Area; b. The improvement, expansion... Rural Utilities Service Announcement of Grant Application Deadlines AGENCY: Rural Utilities Service... Department of Agriculture's (USDA) Rural Utilities Service (RUS) announces its Community Connect Grant...

  19. Evolution, functional divergence and conserved exon-intron structure of bHLH/PAS gene family.

    Science.gov (United States)

    Yan, Jun; Ma, Zhaowu; Xu, Xiaopeng; Guo, An-Yuan

    2014-02-01

    bHLH/PAS genes encode a family of basic helix-loop-helix (bHLH) transcription factors with bHLH, PAS and PAS_3 domain. bHLH/PAS genes are involved in many essential physiological and developmental processes, such as hypoxic response neural development, the circadian clock, and learning ability. Despite their important functions, the origin and evolution of this bHLH/PAS gene family has yet to be elucidated. In this study, we aim to explore the origin, evolution, gene structure conservation of this gene family and provide a model to analyze the evolution of other gene families. Our results show that genes of the bHLH/PAS family only exist in metazoans. They may have originated from the common ancestor of metazoans and expanded into vertebrates. We identified bHLH/PAS genes in more than ten species representing the main lineages and constructed the phylogenetic trees (Beyasian, ML and NJ) to classify them into three groups. The exon-intron structure analysis revealed that a relatively conserved "1001-0210" eight-exon structure exists in most groups and lineages. In addition, we found the exon fusion pattern in several groups in this conserved eight-exon structure. Further analysis indicated that bHLH/PAS protein paralogs evolved from several gene duplication events followed by functional divergence and purifying selection. We presented a phylogenetic model to describe the evolutionary history of the exon structures of bHLH/PAS genes. Taken together, our study revealed the evolutionary model, functional divergence and gene structure conservation of bHLH/PAS genes. These findings provide clues for the functional and evolutionary mechanism of bHLH/PAS genes.

  20. Storage of apheresis platelet concentrates after manual replacement of >95% of plasma with PAS 5.

    Science.gov (United States)

    Morrison, A; McMillan, L; Radwanski, K; Blatchford, O; Min, K; Petrik, J

    2014-10-01

    Recently, a glucose- and bicarbonate-containing additive solution termed PAS 5 demonstrated acceptable 7-day platelet storage after >95% plasma replacement with PAS on the day of collection (Day 0). In this study, we examined platelet storage in >95% PAS 5 after manual washing of Day 1 apheresis platelets in plasma collected using either the Amicus or Trima plateletpheresis devices. Triple platelet donations in plasma were obtained from Amicus (n = 10) and Trima (n = 10) plateletpheresis devices and stored overnight before being centrifuged and manually processed into three units with the following storage media: 100% plasma, >95% PAS 5 or 65% PAS 5/35% plasma. Platelet units were sampled on Days 1, 5 and 7 of storage using a range of tests recommended by the UK guidelines. The majority of in vitro assay results for platelets in PAS 5 were similar to results in paired 100% plasma platelets (controls). The pH of PAS 5 stored platelet units was above the UK recommended guidelines of 7·4 by Day 5. PAS 5 platelets were no more activated than controls as evidenced by comparable soluble P-selectin levels and CD62p and CD42b expression. PAS 5 platelets also exhibited adhesion and aggregation profiles higher than (Day 1) or comparable to (Days 5 and 7) controls as measured by Impact R. The 7-day in vitro storage parameters investigated were comparable between >95% PAS 5 and 100% plasma platelets derived from both Amicus and Trima plateletpheresis devices, with the exception that lactose dehydrogenase release rate and pH were significantly higher in PAS 5 units. © 2014 International Society of Blood Transfusion.

  1. 75 FR 60779 - Announcement of Funding Awards for Fiscal Year 2010; Hispanic-Serving Institutions Assisting...

    Science.gov (United States)

    2010-10-01

    ... facilities, economic development, business entrepreneurship, and fair housing programs. The Catalog of... revitalization, housing and economic development, principally for persons of low-and moderate-income consistent... URBAN DEVELOPMENT Announcement of Funding Awards for Fiscal Year 2010; Hispanic- Serving Institutions...

  2. 75 FR 60778 - Announcement of Funding Awards for Fiscal Year 2010 Historically Black Colleges and Universities...

    Science.gov (United States)

    2010-10-01

    ..., public facilities, economic development, business entrepreneurship, a wide range of public service... URBAN DEVELOPMENT Announcement of Funding Awards for Fiscal Year 2010 Historically Black Colleges and Universities Program AGENCY: Office of the Assistant Secretary for Policy Development and Research, HUD. ACTION...

  3. 76 FR 40876 - Announcement of Grant Application Deadlines and Funding Levels

    Science.gov (United States)

    2011-07-12

    ... Type: Initial announcement. Catalog of Federal Domestic Assistance (CFDA) Number: 10.874. Due Date for...; health care job training programs; and for the development and expansion of public health-related... one area, whether rural or not, to students and teachers who are located in rural areas; or connect...

  4. 75 FR 51749 - Bureau for Democracy, Conflict and Humanitarian Assistance Office of Food for Peace Announcement...

    Science.gov (United States)

    2010-08-23

    ... Humanitarian Assistance Office of Food for Peace Announcement of Draft Request for Applications for Title II Non-Emergency Food Aid Programs; Notice Pursuant to the Food for Peace Act of 2008, notice is hereby... thirty days via the Food for Peace Web site: http://www.usaid.gov/our_work/humanitarian_assistance/ffp...

  5. 78 FR 51211 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in...

    Science.gov (United States)

    2013-08-20

    ... Employment and Training Administration Announcement Regarding a Change in Eligibility for Unemployment... Emergency Unemployment Compensation 2008 (EUC08) Program AGENCY: Employment and Training Administration... found at: http://ows.doleta.gov/unemploy/claims_arch.asp . The following changes have occurred since the...

  6. 77 FR 26241 - Announcement of Grant Application Deadlines and Funding Levels

    Science.gov (United States)

    2012-05-03

    ... agency #0;statements of organization and functions are examples of documents #0;appearing in this section...) announces its Community Connect Grant Program application window for Fiscal Year (FY) 2012. In addition, RUS... determine basic eligibility IV. Application and Submission Information: Where to get application materials...

  7. 77 FR 27015 - Announcement of Grant and Loan Application Deadlines and Funding Levels

    Science.gov (United States)

    2012-05-08

    ... need loan funds. Quantify the number of prospective borrowers or provide statistical or narrative... Rural Utilities Service Announcement of Grant and Loan Application Deadlines and Funding Levels AGENCY... establish a lending program for eligible entities. Eligible entities for the revolving loan fund will be the...

  8. 78 FR 16279 - HUD Healthcare Facility Documents: Notice Announcing Final Approved Documents and Assignment of...

    Science.gov (United States)

    2013-03-14

    ... . This notice published today announces that HUD has completed the notice and comment processes required... its assets to its landlord's loan liabilities. The commenter stated that these issues would be most... participate in HUD programs as a result. However, HUD has determined that, at this time, the need to establish...

  9. 76 FR 30094 - Announcement of Grant and Loan Application Deadlines and Funding Levels

    Science.gov (United States)

    2011-05-24

    ... promoting the safe and productive use of revolving funds. In describing what the project will achieve, you... Financing Water and Wastewater Projects (Revolving Fund Program (RFP)). Announcement Type: Funding Level...: Available funds, maximum amounts. III. Eligibility Information: Who is eligible, what kinds of projects are...

  10. Factor Structure of the PAS-ADD Checklist with Adults with Intellectual Disabilities

    Science.gov (United States)

    Hatton, Chris; Taylor, John J.

    2008-01-01

    Background: The PAS-ADD Checklist is designed to screen for likely mental health problems in people with intellectual disabilities (ID). The specificity of recommended subscales derived from diagnostic criteria is unclear. This paper therefore investigates the factor structure of the PAS-ADD Checklist to determine the adequacy of empirically…

  11. Screening for Psychiatric Symptoms: PAS-ADD Checklist Norms for Adults with Intellectual Disabilities

    Science.gov (United States)

    Taylor, J. L.; Hatton, C.; Dixon, L.; Douglas, C.

    2004-01-01

    The Psychiatric Assessment Schedule for Adults with Developmental Disabilities Checklist (PAS-ADD Checklist) is a screening instrument designed to help carers recognize likely mental health problems in people with intellectual disabilities (ID). To date there are no published PAS-ADD Checklist data on a large nonpsychiatric population of adults…

  12. Within-host competition between barley yellow dwarf-PAV and -PAS.

    Science.gov (United States)

    Hall, Gerod S; Little, Damon P

    2013-06-01

    The PAV and PAS species of barley yellow dwarf virus (Luteoviridae) share hosts, vectors, and have sympatric distributions. To better understand how competition between species influences virus growth within the host, transmission rate between hosts, and ultimately virus population structure two experiments were conducted. The first experiment varied the order of PAV and PAS inoculation and the time interval between the first and second inoculation. Relative virus concentration was measured at 8, 20, 33, and 45 days after primary virus inoculation (dpi). Regardless of the order of inoculation or the length of time between inoculations, PAV dominated the virus population by 33 dpi (PAV concentration ranged from 55% to 89%). The second experiment measured the rate of vector transmission from single and multiple infections. From single infections, the transmission rate was 67% for PAV and 60% for PAS. PAV had significantly greater odds of transmission for all competition treatments-except if PAS was given a 15-day head start before inoculation with PAV. In the latter treatment, PAS was transmitted with a greater frequency than PAV, but the difference was not statistically significant. Our data show persistent co-infection between PAV and PAS, but PAV is more likely to be transmitted from mixed infections. Thus, within-host interactions between PAV and PAS create conditions that promote both the competitive exclusion of PAS, as well as co-existence between species and the maintenance of genetic diversity in the host community. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Ligand binding PAS domains in a genomic, cellular, and structural context

    Science.gov (United States)

    Henry, Jonathan T.; Crosson, Sean

    2012-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains. PMID:21663441

  14. Ligand-binding PAS domains in a genomic, cellular, and structural context.

    Science.gov (United States)

    Henry, Jonathan T; Crosson, Sean

    2011-01-01

    Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins such as sensor histidine kinases, cyclic-di-GMP synthases/hydrolases, and methyl-accepting chemotaxis proteins. Although these domains are highly divergent at the primary sequence level, the structures of dozens of PAS domains across a broad section of sequence space have been solved, revealing a conserved three-dimensional architecture. An all-versus-all alignment of 63 PAS structures demonstrates that the PAS domain family forms structural clades on the basis of two principal variables: (a) topological location inside or outside the plasma membrane and (b) the class of small molecule that they bind. The binding of a chemically diverse range of small-molecule metabolites is a hallmark of the PAS domain family. PAS ligand binding either functions as a primary cue to initiate a cellular signaling response or provides the domain with the capacity to respond to secondary physical or chemical signals such as gas molecules, redox potential, or photons. This review synthesizes the current state of knowledge of the structural foundations and evolution of ligand recognition and binding by PAS domains.

  15. Does DSM-IV Have Equivalents for the Parental Alienation Syndrome (PAS) Diagnosis?

    Science.gov (United States)

    Gardner, Richard A.

    2003-01-01

    Child custody evaluators commonly find themselves confronted with resistance when they attempt to use the term parental alienation syndrome (PAS) in courts of law. The purpose of this article is to elucidate the reasons for the reluctance to use the PAS diagnosis and the applicability of parental alienation, as well as current DSM-IV substitute…

  16. An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.

    Science.gov (United States)

    Ortmayer, Mary; Lafite, Pierre; Menon, Binuraj R K; Tralau, Tewes; Fisher, Karl; Denkhaus, Lukas; Scrutton, Nigel S; Rigby, Stephen E J; Munro, Andrew W; Hay, Sam; Leys, David

    2016-11-24

    The universal Per-ARNT-Sim (PAS) domain functions as a signal transduction module involved in sensing diverse stimuli such as small molecules, light, redox state and gases. The highly evolvable PAS scaffold can bind a broad range of ligands, including haem, flavins and metal ions. However, although these ligands can support catalytic activity, to our knowledge no enzymatic PAS domain has been found. Here we report characterization of the first PAS enzyme: a haem-dependent oxidative N-demethylase. Unrelated to other amine oxidases, this enzyme contains haem, flavin mononucleotide, 2Fe-2S and tetrahydrofolic acid cofactors, and specifically catalyses the NADPH-dependent oxidation of dimethylamine. The structure of the α subunit reveals that it is a haem-binding PAS domain, similar in structure to PAS gas sensors. The dimethylamine substrate forms part of a highly polarized oxygen-binding site, and directly assists oxygen activation by acting as both an electron and proton donor. Our data reveal that the ubiquitous PAS domain can make the transition from sensor to enzyme, suggesting that the PAS scaffold can support the development of artificial enzymes.

  17. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus.

    Science.gov (United States)

    Shah, Neethu; Gaupp, Rosmarie; Moriyama, Hideaki; Eskridge, Kent M; Moriyama, Etsuko N; Somerville, Greg A

    2013-07-31

    The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequence similarity. To gain greater insight into the evolution of PDC/PAS domains present in the bacterial kingdom and staphylococci in specific, the PDC/PAS domains from the genomic sequences of 48 bacteria, representing 5 phyla, were identified using the sensitive search method based on HMM-to-HMM comparisons (HHblits). A total of 1,007 PAS domains and 686 PDC domains distributed over 1,174 proteins were identified. For 28 Gram-positive bacteria, the distribution, organization, and molecular evolution of PDC/PAS domains were analyzed in greater detail, with a special emphasis on the genus Staphylococcus. Compared to other bacteria the staphylococci have relatively fewer proteins (6-9) containing PDC/PAS domains. As a general rule, the staphylococcal genomes examined in this study contain a core group of seven PDC/PAS domain-containing proteins consisting of WalK, SrrB, PhoR, ArlS, HssS, NreB, and GdpP. The exceptions to this rule are: 1) S. saprophyticus lacks the core NreB protein; 2) S. carnosus has two additional PAS domain containing proteins; 3) S. epidermidis, S. aureus, and S. pseudintermedius have an additional protein with two PDC domains that is predicted to code for a sensor histidine kinase; 4) S. lugdunensis has an additional PDC containing protein predicted to be a sensor histidine kinase. This comprehensive analysis demonstrates that variation in PDC/PAS domains among bacteria has limited correlations to the genome size or pathogenicity; however, our analysis established that bacteria having a motile phase in their life cycle have significantly more PDC/PAS-containing proteins. In addition, our analysis revealed a tremendous amount of variation in the

  18. Observations of noise exposure through the use of headphones by radio announcers.

    Science.gov (United States)

    Williams, W; Presbury, J

    2003-01-01

    This study examined the potential risk of hearing loss by commercial radio announcers. This risk is developed through the regular use of headphones. These headphones are used to monitor broadcast transmission and communication information from program producers. To our knowledge there are no published studies of the noise exposure of radio announcers. The experimental method utilised a headphone parallel to the one in use mounted on a wideband, artificial ear. A Sound Level Meter was then used to measure the sound level and then calculate the exposure level. Depending on the feedback level applied to their headphones radio announcers are exposed to potentially damaging levels of noise. Levels measured correlate with results from other studies of long-term average speech spectrum and voice level measurements.

  19. Automated Announcements of Approaching Emergency Vehicles

    Science.gov (United States)

    Bachelder, Aaron; Foster, Conrad

    2006-01-01

    Street intersections that are equipped with traffic lights would also be equipped with means for generating audible announcements of approaching emergency vehicles, according to a proposal. The means to generate the announcements would be implemented in the intersection- based subsystems of emergency traffic-light-preemption systems like those described in the two immediately preceding articles and in "Systems Would Preempt Traffic Lights for Emergency Vehicles" (NPO-30573), NASA Tech Briefs, Vol. 28, No. 10 (October 2004), page 36. Preempting traffic lights is not, by itself, sufficient to warn pedestrians at affected intersections that emergency vehicles are approaching. Automated visual displays that warn of approaching emergency vehicles can be helpful as a supplement to preemption of traffic lights, but experience teaches that for a variety of reasons, pedestrians often do not see such displays. Moreover, in noisy and crowded urban settings, the lights and sirens on emergency vehicles are often not noticed until a few seconds before the vehicles arrive. According to the proposal, the traffic-light preemption subsystem at each intersection would generate an audible announcement for example, emergency vehicle approaching, please clear intersection whenever a preemption was triggered. The subsystem would estimate the time of arrival of an approaching emergency vehicle by use of vehicle identity, position, and time data from one or more sources that could include units connected to traffic loops and/or transponders connected to diagnostic and navigation systems in participating emergency vehicles. The intersection-based subsystem would then start the announcement far enough in advance to enable pedestrians to leave the roadway before any emergency vehicles arrive.

  20. Realized Bond-Stock Correlation: Macroeconomic Announcement Effects

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Ranaldo, Angelo

    2005-01-01

    We investigate the effects of macroeconomic announcements on the realized correlation between bond and stock returns. Our results deliver insights into the dominating drivers of bond-stock comovements. We find that it is not so much the surprise component of the announcement, but the mere fact...... that an announcement occurs that influences the realized bond-stock correlation. The impact of macroeconomic announcements varies across the business cycle. Announcement effects are highly dependent on the sign of the realized bond-stock correlation which has recently gone from positive to negative. Macroeconomic...

  1. OPENING THE SCHOOLHOUSE GATE: WHY THE SUPREME COURT SHOULD ADOPT THE STANDARD ANNOUNCED IN TATRO v. UNIVERSITY OF MINNESOTA TO PERMIT THE REGULATION OF CERTAIN NON-CURRICULAR STUDENT SPEECH IN PROFESSIONAL PROGRAMS

    National Research Council Canada - National Science Library

    Mark A Cloutier

    2014-01-01

    ... speech rights beyond them. This Note examines what happens when a student enrolled in a post-secondary program violates an established code of conduct or professional ethics using a non-curricular form of Internet communication...

  2. Bacterial growth kinetics in ACD-A apheresis platelets: comparison of plasma and PAS III storage.

    Science.gov (United States)

    Dumont, Larry J; Wood, Tammara A; Housman, Molly; Herschel, Louise; Brantigan, Barbara; Heber, Cheryl; Houghton, Jaime

    2011-05-01

    Our objective was to determine the growth kinetics of bacteria in leukoreduced apheresis platelets (LR-AP) in a platelet (PLT) additive solution (PAS; InterSol, Fenwal, Inc.) compared to LR-AP stored in plasma. Hyperconcentrated, double-dose LR-AP were collected from healthy donors with a separator (AMICUS, Fenwal, Inc.). LR-AP were evenly divided, InterSol was added to half (65% InterSol:35% plasma [PAS]), and PLTs in autologous plasma were used for a paired control (PL). Bacteria were inoculated into each LR-AP PAS/PL pair (0.5-1.6 colony-forming units [CFUs]/mL), and bacterial growth was followed for up to 7 days. Time to the end of the lag phase, doubling times, maximum concentration (conc-max), and time to maximum concentration (time-max) were estimated. Streptococcus viridans did not grow to detectable levels in either PAS or PL units. The other bacteria had no significant overall difference in the conc-max (p = 0.47) or time-max (p = 0.7) between PL and PAS LR-AP; PL had a 0.14 hours faster doubling rate (p = 0.023); and PAS had a 4.7 hours shorter lag time (p = 0.016). We observed that five index organisms will grow in LR-AP stored in a 35%:65% ratio of plasma to InterSol where initial bacterial concentrations are 0.5 to 1.6 CFUs/mL. The more rapid initiation of log-phase growth for bacteria within a PAS storage environment resulted in a bacterial concentration up to 4 logs higher in the PAS units compared to the plasma units at 24 hours, but with no difference in the conc-max. This may present an early bacterial detection advantage for PAS-stored PLTs. © 2010 American Association of Blood Banks.

  3. How electronic health records can unmask the hidden value of PAs.

    Science.gov (United States)

    Ogunfiditimi, Folusho; Sherry, Scott P; Foote, Monica; Christie, Sarah L; Shock, Lisa P; Cawley, James; Browne, Aaron

    2017-06-01

    The Fee for Value (FFV) Task Force, a subgroup of the American Academy of PAs' Research and Strategic Initiatives Commission, has examined tools and mechanisms aimed at better clarifying the volume and value of PA work and how that work contributes to improving access to high-quality care. Establishing the value of PAs has been a challenging task for many healthcare providers. Often, PA value has been defined by their clinical productivity, without any clear direction as to what constitutes value versus productivity. The objective of this article is to unmask the value of PAs through the role of electronic health records and highlight PAs' ability to produce services that are value-oriented and quantifiably productive.

  4. ON THE MYTH OF PARENTAL ALIENATION SYNDROME (PAS AND THE DSM-5

    Directory of Open Access Journals (Sweden)

    Ramón Vilalta

    2017-09-01

    Full Text Available This paper discusses the controversy over the existence of Parental Alienation Syndrome (PAS or any other name it may be given. The negative judgements regarding PAS are diverse in nature: from criticism about the personality of the term’s creator, to the most repeated criticism that PAS does not exist in the Diagnostic and Statistical Manual of Mental Disorders DSM-5. This paper analyzes some of these criticisms in the Spanish judicial context, especially those exposed in the Guidelines of the Group of Experts on the Fight against Domestic and Gender Violence of the General Council of the Judiciary (CGPJ, published in 2016. It is argued that PAS is widely recognized by the professional and scientific community and may be described and classified in the DSM-5 as a “Parent–Child Relational Problem V61.20 (Z62.820”.

  5. Form Quality in Rorschach Comprehensive System and R-PAS: Sample of Psychiatric Cases

    Directory of Open Access Journals (Sweden)

    Latife Yazigi

    2016-04-01

    Full Text Available Abstract The creation of the Rorschach Performance Assessment System (R-PAS requires research that allows its use in the Brazilian population. The Formal Quality (FQ category is essential both for clinic and research. The aim of this study was to compare form quality variables in Rorschach protocols from psychiatric patients and ratings coded in the Comprehensive System (CS and R-PAS. The sample comprised 206 Rorschach protocols from adult patients in psychiatric treatment, who were also assessed by SCID-I and SCID-II. Most protocols were administered in the CS and recoded according to the R-PAS. The kappa coefficient was calculated, and we compared the means of these variables in both systems. The kappa results varied from almost perfect to substantial consistency for all variables, however, the descriptive statistics confirmed that the R-PAS elicits more FQ Ordinary coding while the CS elicits more FQ minus coding.

  6. Periodic acid-Schiff (PAS) staining of immature platelets in donors.

    Science.gov (United States)

    Pogorelov, Valery M; Beskorovainova, Victoria Ju; Chanieva, Marem I; Dyagileva, Olga A; Naumova, Iren N; Skedina, Marina A

    2012-01-01

    Glycogen in platelets (PLTs) on smears of peripheral blood of 40 donors was investigated by the periodic acid-Schiff (PAS) method. Three groups were formed. Group 1 was consisted of 21 men undergoing the donor selection procedure. Additionally, 9 first-time donors undergoing plateletpheresis (Group 2) and 10 donors who frequently underwent platelet apheresis (Group 3) were studied as a model of relative thrombocytopenia. Cell sizes were measured with the use of a Image Analyzer "ASPBC" (Russia). The training procedure and classification of PAS-blood PLTs were made on the basis of expert evaluation. In this article, we have established three facts. First, the PAS-positive PLT area was larger than that of the PAS-negative cells (9.5 ± 3.6 sq.mkm vs. 3.9 ± 1.3 sq.mkm, p PAS-positivity of PLTs was 23.1 ± 9.2%. Second, the PAS-positivity correlated (r(S) = 0.63, p PAS positivity [r(S) = 0.5 (p = 0.14) and r(S) = 0.6 (p = 0.05)] which has a tendency to increase [Group 2: median PAS 24.3% (95% CI 14.8-26.2) vs. median PAS 30% (95% CI 21.6-34.2), p = 0.05 and Group 3: median PAS 31% (95% CI 19-36.4) vs. median PAS 27.4% (95% CI 18.7-34.9), p = 0.35] and correlated negatively with the decrease in the platelet count [Group 2: r(S) = -0.7 (p = 0.21) and Group 3: r(S) = -0.5 (p = 0.14)]. Our findings support the significance of platelet evaluation by light microscopy to understand why morphologic changes of thrombocytopoiesis may be expected in thrombocytopenia due to donation of platelets.

  7. Prevalence and factors determining psychoactive substance (PAS) use among Hawassa University (HU) undergraduate students, Hawassa Ethiopia.

    Science.gov (United States)

    Kassa, Andargachew; Taddesse, Fiker; Yilma, Aweke

    2014-10-07

    Use of psychoactive substances (PAS) early in school age implies drug dependence in later life. Although no studies have been conducted on undergraduate students of Hawassa University, a few studies in Ethiopia have reported that alcohol, khat, and cigarette are the commonly abused PASs among young high school/undergraduate university students. Therefore, this study was designed to establish the prevalence of and predictors for PAS use among undergraduate HU Students. An institution-based quantitative cross-sectional study using the self-administered WHO Model Core Questionnaire to collect information on use of various Psychoactive Substances (PASs) was conducted from June to July 2011. A multistage stratified sampling method was employed to select a total of 586 undergraduate HU students as study participants. Bivariate and multivariate logistic regression analysis were done to determine factors affecting PAS use. Lifetime, past 12 months, and current prevalence rate for overall PAS were 53.6%, 45.7%, and 35.5% respectively. The study depicted that in the past 12 months of the study period 40.8% used alcohol, 20.3% chewed khat, 11.9% smoked cigarettes, and 0.9% used marijuana. The prevalence of other illicit PASs such as Ecstasy, lysergic diethylamide (LSD), cocaine, crack, heroin, solvents or inhalants and un-prescribed psycho active medications was found zero percent (0%). Having family members who used PAS, peer influence, being male, and living alone during school age were found to be positively associated with overall PAS use in the past 12 months. The prevalence of PAS use among undergraduate HU students is high. Designing effective strategies to reduce PAS use should be everyone's priority.

  8. EGF increases expression and activity of PAs in preimplantation rat embryos and their implantation rate

    Directory of Open Access Journals (Sweden)

    Har-Vardi Iris

    2007-01-01

    Full Text Available Abstract Background Embryo implantation plays a major role in embryogenesis and the outcome of pregnancy. Plasminogen activators (PAs have been implicated in mammalian fertilization, early stages of development and embryo implantation. As in-vitro developing embryos resulted in lower implantation rate than those developed in-vivo we assume that a reduced PAs activity may be involved. In the present work we studied the effect of EGF on PAs activity, quantity and embryo implantation. Methods Zygotes were flushed from rat oviducts on day one of pregnancy and grown in-vitro in R1ECM supplemented with EGF (10 ng/ml and were grown up to the blastocyst stage. The control groups were grown in the same medium without EGF. The distribution and quantity of the PAs were examined using fluorescence immunohistochemistry followed by measurement of PAs activity using the chromogenic assay. Implantation rate was studied using the embryo donation model. Results PAs distribution in the embryos was the same in EGF treated and untreated embryos. Both PAs were localized in the blastocysts' trophectoderm, supporting the assumption that PAs play a role in the implantation process in rats. EGF increased the quantity of uPA at all stages studied but the 8-cell stage as compared with controls. The tissue type PA (tPA content was unaffected except the 8-cell stage, which was increased. The activity of uPA increased gradually towards the blastocyst stage and more so due to the presence of EGF. The activity of tPA did not vary with the advancing developmental stages although it was also increased by EGF. The presence of EGF during the preimplantation development doubled the rate of implantation of the treated group as compared with controls.

  9. Le potager n'est pas plus vert chez le voisin | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    8 sept. 2016 ... D'abord, un problème demarché, car les gens ne connaissaient pas les avantages alimentaires de ces légumes. Il y avait aussi un problème d'usage, car les gens ignoraient comment les préparer. Et, finalement, un problème d'ordre agronomique, c'est-à-dire que les agriculteurs ne savaient pas les ...

  10. Purification of the major group 1 allergen from Bahia grass pollen, Pas n 1.

    Science.gov (United States)

    Drew, Alexander C; Davies, Janet M; Dang, Thanh D; Rolland, Jennifer M; O'Hehir, Robyn E

    2011-01-01

    Group 1 grass pollen allergens are glycoproteins of the β-expansin family. They are a predominant component of pollen and are potent allergens with a high frequency of serum IgE reactivity in grass pollen-allergic patients. Bahia grass is distinct from temperate grasses and has a prolonged pollination period and wide distribution in warmer climates. Here we describe the purification of the group 1 pollen allergen, Pas n 1, from Bahia grass (Paspalum notatum), an important subtropical aeroallergen source. Pas n 1 was purified from an aqueous Bahia grass pollen extract by ammonium sulphate precipitation, hydrophobic interaction and size exclusion chromatography, and assessed by one- and two-dimensional gel electrophoresis, immunoblotting and ELISA. Pas n 1 was purified to a single 29-kDa protein band containing two dominant isoforms detected by an allergen-specific monoclonal antibody and serum IgE of a Bahia grass pollen-allergic donor. The frequency of serum IgE reactivity with purified Pas n 1 in 51 Bahia grass pollen-allergic patients was 90.6%. Serum IgE reactivity with purified Pas n 1 was highly correlated with serum IgE reactivity with Bahia grass pollen extract and recombinant Pas n 1 (r = 0.821 and 0.913, respectively). Pas n 1 is a major allergen reactive at high frequency with serum IgE of Bahia grass pollen-allergic patients. Purified natural Pas n 1 has utility for improved specific diagnosis and immunotherapy for Bahia grass pollen allergy. Copyright © 2010 S. Karger AG, Basel.

  11. Robustness and evolvability in the functional anatomy of a PER-ARNT-SIM (PAS) domain.

    Science.gov (United States)

    Philip, Andrew F; Kumauchi, Masato; Hoff, Wouter D

    2010-10-19

    The robustness of proteins against point mutations implies that only a small subset of residues determines functional properties. We test this prediction using photoactive yellow protein (PYP), a 125-residue prototype of the PER-ARNT-SIM (PAS) domain superfamily of signaling proteins. PAS domains are defined by a small number of conserved residues of unknown function. We report high-throughput biophysical measurements on a complete Ala scan set of purified PYP mutants. The dataset of 1,193 values on active site properties, functional kinetics, stability, and production level reveals that 124 mutants retain the characteristic photocycle of PYP, but that the majority of substitutions significantly alter functional properties. Only 35% of substitutions that strongly affect function are located at the active site. Unexpectedly, most PAS-conserved residues are required for maintaining protein production. PAS domain activation often involves conformational changes in α-helices linked to the PAS core. However, the mechanism of transmission and kinetic regulation of allosteric structural changes from the PAS domain to these helices is not clear. The Ala scan data reveal interactions governing allosteric switching in PYP. The photocycle kinetics is significantly altered by substitutions at 58 positions and spans a 3,000-fold range. Nine residues that dock the N-terminal α-helices of PYP to its PAS core regulate signaling kinetics. Ile39 and Asn43 are identified as part of a mechanism for regulating allosteric switching that is conserved among PAS domains. These results show that PYP combines robustness with a high degree of evolvability and imply production level as an important factor in protein evolution.

  12. PAS-cal: a generic recombinant peptide calibration standard for mass spectrometry.

    Science.gov (United States)

    Breibeck, Joscha; Serafin, Adam; Reichert, Andreas; Maier, Stefan; Küster, Bernhard; Skerra, Arne

    2014-08-01

    We describe the design, preparation, and mass-spectrometric characterization of a new recombinant peptide calibration standard with uniform biophysical and ionization characteristics for mass spectrometry. "PAS-cal" is an artificial polypeptide concatamer of peptide cassettes with varying lengths, each composed of the three small, chemically stable amino acids Pro, Ala, and Ser, which are interspersed by Arg residues to allow site-specific cleavage with trypsin. PAS-cal is expressed at high yields in Escherichia coli as a Small Ubiquitin-like MOdifier (SUMO) fusion protein, which is easily purified and allows isolation of the PAS-cal moiety after SUMO protease cleavage. Upon subsequent in situ treatment with trypsin, the PAS-cal polypeptide yields a set of four defined homogeneous peptides in the range from 2 to 8 kDa with equal mass spacing. ESI-MS analysis revealed a conveniently interpretable raw spectrum, which after deconvolution resulted in a very simple pattern of four peaks with similar ionization signals. MALDI-MS analysis of a PAS-cal peptide mixture comprising both the intact polypeptide and its tryptic fragments revealed not only the four standard peptides but also the singly and doubly charged states of the intact concatamer as well as di- and trimeric adduct ion species between the peptides, thus augmenting the observable m/z range. The advantageous properties of PAS-cal are most likely a result of the strongly hydrophilic and conformationally disordered PEG-like properties of the PAS sequences. Therefore, PAS-cal offers an inexpensive and versatile recombinant peptide calibration standard for mass spectrometry in protein/peptide bioanalytics and proteomics research, the composition of which may be further adapted to fit individual needs.

  13. Les scientifiques du CERN n'oublient pas l'Irak pour eux, les préoccupations humanitaires n'ont pas de passeport

    CERN Multimedia

    2003-01-01

    Scientists from the CERN club ConCERNed for Humanity have written to the Swiss Federal Councellor, Micheline Calmy-Rey, with 550 signatures on a petition "pas en notre nom" - not in our name - to ask her to do all that is in her capacity to end the conflict in Iraq (0.5 page)

  14. PAs in orthopedics in the VHA's community-based outpatient clinics.

    Science.gov (United States)

    Reed, Daniel O; Hooker, Roderick S

    2017-04-01

    In the Veterans Health Administration (VHA) system, most orthopedic care takes place in the VA medical centers (VAMCs). Because most patients receiving orthopedic care were referred by adult medicine providers, more widely deploying physician assistants (PAs) in orthopedic medicine might help offset this workload. An orthopedic medicine demonstration project recruited, trained, and positioned PAs in community-based outpatient clinics (CBOCs) to improve access to care. The project involved surgeons at the Houston VAMC instructing five newly employed PAs in a wide range of orthopedic evaluation and management strategies before their assignment to a CBOC. An administrative assessment compared encounter data pre- and postproject (2012 and 2014) to determine if this strategy modified orthopedic workload and improved patient access to care. By 2014, orthopedic patient visit volume had increased 31%-10% at the VAMC and 21% at the five CBOCs. Overall, the five deployed PAs managed 28% of all orthopedic encounters spread over 1 year and only 3.2% of visits required VAMC referral for further evaluation or treatment. During the project, the total volume of patient visits increased throughout the Houston VAMC region but access to care for this specialty service also increased, with more veteran musculoskeletal care being met at the five CBOCs, off-loading visit demand centrally. The adaptability and flexibility of new roles has been identified as one of the defining characteristics of PAs. That the VHA can take advantage of this role malleability suggests that employing PAs is useful in meeting medical service needs of veterans.

  15. Homodimerization of the PAS-B domains of hypoxia-inducible factors.

    Science.gov (United States)

    Zhu, Jing; Martinez-Yamout, Maria; Cardoso, Rosa; Yan, Jiangli; Love, Robert A; Grodsky, Neil; Brooun, Alexei; Dyson, H Jane

    2012-06-14

    The Per-Arnt-Sim (PAS) domains of hypoxia-inducible transcription factors (HIF) mediate heterodimer formation between the HIF-α forms that are induced in the event of cellular hypoxia and the constitutive HIF-β variants. Previous efforts toward structural characterization of the HIF-1α PAS domains were limited by protein stability. Using homology modeling based on the published crystal structure of the PAS-B domain of the homologous protein HIF-2α in complex with the partner HIF-β (also known as ARNT), we have identified a variant of HIF-1α with improved solubility, monodispersity, and stability. Purified solutions of the PAS-B domains of HIF-1α and HIF-2α differ in their propensity for homodimer formation. In an attempt to understand the structural basis for this difference, and to document the structural changes that accompany homodimer formation, we have undertaken a comparative NMR study of the PAS-B domains of HIF-1α and HIF-2α and mutants of HIF-1α that mimic the behavior of HIF-2α. The NMR spectra of all of these domains are very similar, consistent with the similarity of their amino acid sequences. However, the greater propensity of the HIF-1α PAS-B domain to form dimers as the concentration was increased allowed us to determine the site of homodimerization and pointed toward possible sequence changes in HIF-1α that might discourage the formation of homodimers.

  16. Solar lease grant program. Technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    Progress on a lease program for the installation of a solar water heater with no installation charge is reported. Information on the announcement of the program, the selection of participants, the contractural agreement, progress on installation of equipment, monitoring, and evaluation is summarized. The status of the budget concerned with the program is announced. Forms used for applications for the program and an announcement from Resource Alternatives for Cilco customers are presented.

  17. A STUDY OF ERROR ON ENGLISH SPEECH USED BY THE RADIO ANNOUNCER AT BRASS FM KEDIRI

    Directory of Open Access Journals (Sweden)

    Rino Sardanto

    2014-05-01

    Full Text Available Error is violation from the rule of English grammar. The purpose of this study is to describe the kinds of errors and to calculate the frequency of occurrences of the types of errors made by the announcer at Brass FM Kediri. The data in this study were obtained from the English conversation program at Brass FM Kediri. The data was collected by doing 2 week observation to investigate the process of English conversation between announcer and participants of Brass FM in English Corner program. The researcher used the recording to know the errors of English speaking made by the announcer. The errors found were analyzed using Surface Strategy Taxonomy from Dulay (1982 and were classified into errors of omission, errors of addition, errors of misformation, and errors of disordering. Based on the analysis, it is show that highest frequency of occurrence of the types of errors is misformation with the percentage 47.92 %, omission with the percentage 33.33 % then followed by addition with the percentage of 16.67%, and the last percentage disordering 2.08%. From the data above that the announcer still makes errors in using grammar especially in the use of plural –s/-es, pronoun and to be. Based on the result of the study, it can be concluded that the announcer of radio Brass FM in English Corner still has many problems in using grammar in conversation on English broadcast. It suggests that the language learner must study more about English grammar and not forget to pay attention the punctuation, conjunction, preposition and any kinds of tenses to make of English grammar mastery.

  18. MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.

    Science.gov (United States)

    Sullivan, Adrienne E; Peet, Daniel J; Whitelaw, Murray L

    2016-09-01

    Transcription factors of the basic helix-loop-helix (bHLH) PER-ARNT-SIM (PAS) family generally have critical and nonredundant biological roles, but some bHLH PAS proteins compete for common cofactors or recognise similar DNA elements. Identifying factors that regulate function of bHLH PAS proteins, particularly in cells where multiple family members are coexpressed, is important for understanding bHLH PAS factor biology. This study identifies and characterises a novel interaction between melanoma-associated antigen D1 (MAGED1) and select members of the bHLH PAS transcription factor family. MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AhR, HIF1α and ARNT. This interaction is mediated by PAS repeat regions which also form the interface for bHLH PAS dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS dimers. We show that MAGED1 does not affect bHLH PAS protein levels and cannot be acting as a coactivator of transcriptionally active heterodimers, but rather appears to interact with nascent bHLH PAS proteins in the cytoplasm to enhance their function prior to nuclear import. As a selective regulator, MAGED1 may play an important role in the biology of these specific factors and in general bHLH PAS protein dynamics. © 2016 Federation of European Biochemical Societies.

  19. Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes.

    Science.gov (United States)

    Upadhyay, Amit A; Fleetwood, Aaron D; Adebali, Ogun; Finn, Robert D; Zhulin, Igor B

    2016-04-01

    Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several transmembrane receptors. However, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domain models, and thus their distribution across the genomic landscape remains largely unknown. Here we show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which is homologous to, but distinct from the PAS superfamily. Our newly built computational models enabled identification of Cache domains in tens of thousands of signal transduction proteins including those from important pathogens and model organisms. Furthermore, we show that Cache domains comprise the dominant mode of extracellular sensing in prokaryotes.

  20. Hardware Interface Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio Ssystem (STRS) Radio

    Science.gov (United States)

    Shalkhauser, Mary Jo W.; Roche, Rigoberto

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

  1. Waveform Developer's Guide for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

    Science.gov (United States)

    Shalkhauser, Mary Jo W.; Roche, Rigoberto

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS-compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx(Trademark) ML605 Virtex(Trademark)-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek(Trademark) eBox 620-110-FL) running the Ubuntu 12.4 operating system. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications. The purpose of this document is to describe how to develop a new waveform using the RIACS platform and the Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) FPGA wrapper code and the STRS implementation on the Axiomtek processor.

  2. The Parkinson Anxiety Scale (PAS): development and validation of a new anxiety scale.

    Science.gov (United States)

    Leentjens, Albert F G; Dujardin, Kathy; Pontone, Gregory M; Starkstein, Sergio E; Weintraub, Daniel; Martinez-Martin, Pablo

    2014-07-01

    Existing anxiety rating scales have limited construct validity in patients with Parkinson's disease (PD). This study was undertaken to develop and validate a new anxiety rating scale, the Parkinson Anxiety Scale (PAS), that would overcome the limitations of existing scales. The general structure of the PAS was based on the outcome of a Delphi procedure. Item selection was based on a canonical correlation analysis and a Rasch analysis of items of the Hamilton Anxiety Rating Scale (HARS) and the Beck Anxiety Inventory (BAI) from a previously published study. Validation was done in a cross-sectional international multicenter study involving 362 patients with idiopathic PD. Patients underwent a single screening session in which the PAS was administered, along with the Hamilton Depression Rating Scale, the HARS, and the BAI. The Mini International Neuropsychiatric Interview was administered to establish Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnoses of anxiety and depressive disorders. The PAS is a 12-item observer or patient-rated scale with three subscales, for persistent, episodic anxiety and avoidance behavior. Properties for acceptability and reliability met predetermined criteria. The convergent and known groups validity was good. The scale has a satisfactory factorial structure. The area under the receiver operating characteristics curve and Youden index of the PAS are higher than that of existing anxiety rating scales. The PAS is a reliable and valid anxiety measure for use in PD patients. It is easy and brief to administer, and has better clinimetric properties than existing anxiety rating scales. The sensitivity to change of the PAS remains to be assessed. © 2014 International Parkinson and Movement Disorder Society.

  3. Evaluating the PAS-SIM model using a passive air sampler calibration study for pesticides.

    Science.gov (United States)

    Restrepo, Andrés Ramírez; Hayward, Stephen J; Armitage, James M; Wania, Frank

    2015-07-01

    The main objective of this study was to evaluate the performance of a model for simulating the uptake of various pesticides on passive air samplers (PAS). From 2006-2007 a series of PAS using XAD-resin were deployed at Egbert, a rural agricultural site in southern Ontario, Canada, to measure the uptake of pesticides for time periods ranging from two months to one year. A continuous increase in sequestered amounts was observed for most pesticides, except for trifluralin and pendimethalin, which could conceivably be subject to substantial degradation inside the sampler. Continuous low-volume active air samples taken during the same period, along with data on weather conditions, allowed for the simulation of the uptake of the pesticides using the model (PAS-SIM). The modelled accumulation of pesticides on the PAS over the deployment period was in good agreement with the experimental data in most cases (i.e., within a factor of two) providing insight into the uptake kinetics of this type of sampler in the field. Passive sampling rates (PSR, m(3) d(-1)) were determined from the empirical data generated for this study using three different methods and compared with the PSRs generated by the model. Overall, the PAS-SIM model, which is capable of accounting for the influence of temperature and wind variations on PSRs, provided reasonable results that range between the three empirical approaches employed and well-established literature values. Further evaluation and application of the PAS-SIM model to explore the potential spatial and temporal variability in PAS uptake kinetics is warranted, particularly for established monitoring sites where detailed meteorological data are more likely to be available.

  4. 78 FR 34395 - Announcement of Foreign-Trade Zones Test

    Science.gov (United States)

    2013-06-07

    ... SECURITY U.S. Customs and Border Protection Announcement of Foreign-Trade Zones Test AGENCY: U.S. Customs... announces U.S. Customs and Border Protection's (``CBP's'') plan to conduct a voluntary general test regarding certain foreign-trade zone (``FTZ'' or ``zone'') activities. Pursuant to the FTZ test, under...

  5. 75 FR 76056 - FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT:

    Science.gov (United States)

    2010-12-07

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Sunshine Act Meeting FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT: STATUS: Closed meeting. PLACE: 100 F Street, NE., Washington, DC. DATE AND TIME OF PREVIOUSLY ANNOUNCED MEETING: Thursday...

  6. Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review).

    Science.gov (United States)

    Li, Yumin; Wei, Yucai; Guo, Jiwu; Cheng, Yusheng; He, Wenting

    2015-07-01

    MicroRNAs (miRNAs) are recognized as an emerging class of master regulators that regulate human gene expression at the post-transcriptional level and are involved in many normal and pathological cellular processes. Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcriptional regulators that sense and respond to environmental signals (such as chemical pollutants) or to physiological signals (for instance hypoxia). In the normal state, bHLH-PAS proteins are responsible for multiple critical aspects of physiology to ensure the cell accurate homeostasis, but dysregulation of these proteins has been shown to contribute to carcinogenic events such as tumor initiation, promotion, and progression. Increasing epidemiological and experimental studies have shown that bHLH-PAS proteins regulate a panel of miRNAs, whereas some miRNAs also target bHLH-PAS proteins. The interaction between miRNAs and certain bHLH-PAS proteins [hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AHR)] is relevant to many vital events associated with tumorigenesis. This review will summarize recent findings on the interesting and complicated underlying mechanisms that miRNAs interact with HIFs or AHR in tumors, hopefully to benefit the discovery of novel drug-interfering targets for cancer therapy.

  7. The National Ambulatory Medical Care Survey: PAs and NPs in outpatient surgery.

    Science.gov (United States)

    Salibian, Ara A; Mahboubi, Hossein; Patel, Madhukar S; Kuan, Edward C; Malinoski, Darren J; Vagefi, Parsia A; Djalilian, Hamid R

    2016-05-01

    This study aimed to determine the prevalence and occupational characteristics of physician assistants (PAs) and nurse practitioners (NPs) in outpatient surgical subspecialty clinics. The 2007 and 2008 National Ambulatory Medical Care Survey (NAMCS) databases were queried for the number and characteristics of office visits seen by different provider types (PAs or NPs, physicians, or both) in various surgical subspecialties. More than 250 million weighted sample visits were analyzed. PAs or NPs were involved in 5.9% of visits, though the percentage of patients seen by them alone (1.1%) was significantly lower (PPAs and NPs were more likely to be involved in pre- or postoperative visits, and often saw the same diagnoses alone as physicians only. The most common procedures performed by PAs and NPs varied according to subspecialty. PAs and NPs have a minor prevalence in the ambulatory surgical workforce during the time period studied. Further integration of these providers into the outpatient setting may help optimize efficiency in ambulatory surgical care.

  8. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.

    Science.gov (United States)

    Hellhammer, J; Fries, E; Buss, C; Engert, V; Tuch, A; Rutenberg, D; Hellhammer, D

    2004-06-01

    Phosphatidylserine, derived from cow brains, has been shown previously to dampen the ACTH and cortisol response to physical stress. Further research investigated the influence of soy lecithin phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. In this study, we investigated the effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) supplementation on pituitary adrenal reactivity (ACTH, cortisol) and on the psychological response (Spielberger State Anxiety Inventory stress subscale) to a mental and emotional stressor. Four groups of 20 subjects were treated for three weeks with daily dosages of either 400 mg PAS, 600 mg PAS, 800 mg PAS, or placebo before exposure to the Trier Social Stress Test (TSST). Treatment with 400 mg PAS resulted in a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the TSST, but did not affect heart rate. The effect was not seen with larger doses of PAS. With regard to the psychological response, 400 mg PAS seemed to exert a specific positive effect on emotional responses to the TSST. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PAS showed decreased distress. These data provide initial evidence for a selective stress dampening effect of PAS on the pituitary-adrenal axis, suggesting the potential of PAS in the treatment of stress related disorders.

  9. 75 FR 42832 - Proposed Collection; Comment Request for Announcement 2004-46

    Science.gov (United States)

    2010-07-22

    ...(c)(2)(A)). Currently, the IRS is soliciting comments concerning Announcement 2004-4, Son of Boss...: Title: Son of Boss Settlement Initiative. OMB Number: 1545-1885. Announcement Number: Announcement 2004...

  10. Faux pas detection and intentional action in Asperger Syndrome. A replication on a French sample.

    Science.gov (United States)

    Zalla, Tiziana; Sav, Anca-Maria; Stopin, Astrid; Ahade, Sabrina; Leboyer, Marion

    2009-02-01

    In the present study, we investigated mind reading abilities in a group of adults with Asperger Syndrome (AS) by using the faux pas task, an advanced test of theory of mind (Baron-Cohen et al. (1999). Journal of Autism and Developmental Disorders, 29, 407-418). The faux pas is a particular case of a non-intentional action reflecting an involuntary socially inappropriate behavior. Here, individuals with AS over-detected faux pas stories, failed to provide correct justifications of the speaker's behavior and were unaware of the mistaken belief and of the resulting emotional impact, whereas they appeared to be responsive to social rule violations. We hypothesized that because of an impaired theory-of-mind, individuals with AS may develop compensatory cognitive strategies based on overlearned abstract knowledge about normative rules.

  11. Epitaxial nanowire formation in metamorphic GaAs/GaPAs short-period superlattices

    Science.gov (United States)

    Zheng, Nan; Ahrenkiel, S. Phillip

    2017-07-01

    Metamorphic growth presents routes to novel nanomaterials with unique properties that may be suitable for a range of applications. We discuss self-assembled, epitaxial nanowires formed during metalorganic chemical vapor deposition of metamorphic GaAs/GaPAs short-period superlattices. The heterostructures incorporate strain-engineered GaPAs compositional grades on 6°-B miscut GaAs substrates. Lateral diffusion within the SPS into vertically aligned, three-dimensional columns results in nanowires extending along A directions with a lateral period of 70-90 nm. The microstructure is probed by transmission electron microscopy to confirm the presence of coherent GaAs nanowires within GaPAs barriers. The compositional profile is inferred from analysis of {200} dark-field image contrast and lattice images.

  12. Criterion validity of the Physical Activity Scale (PAS2) in Danish adults

    DEFF Research Database (Denmark)

    Lunde Pedersen, Eva Sophie; Mortensen, L H; Brage, S

    2017-01-01

    and heart rate sensor for seven days. Average daily estimates from PAS2 were categorised into time spent in sedentary behaviour, light PA, moderate PA and vigorous PA and were compared to the objective measures. RESULTS: PAS2 accounted for 19.5 hours/day on average. Time spent in sedentary behaviour, light...... and moderate-intensity PA was weakly correlated with objective data (polychoric correlation coefficients (PCC): 0.18-0.20), whereas vigorous intensity PA was moderately correlated (PCC: 0.54, p = 0.04). Mean bias was -2.3 hours/day (95% limits of agreement (LoA): -9.04 to 4.34) for sedentary behaviour, 1....... CONCLUSIONS: PAS2 overestimated time spent on light, moderate and vigorous intensity PA and underestimated time spent on sedentary behaviour. Validity differed by key socio-demographic characteristics....

  13. Comparison of results of recording made with the use of the PAS-2 and WLIS equipment

    Energy Technology Data Exchange (ETDEWEB)

    Kornowski, J.; Mirek, A.; Wasko, A. (Glowny Instytut Gornictwa, Katowice (Poland))

    1990-07-01

    Deals with the applicability of rock burst hazard criteria used with the PAS-2 seismoacoustic equipment to results of seismoacoustic recordings obtained with the aid of the WLIS multichannel seismoacoustic pulse counter. Differences between the two equipment types are discussed. Number of pulses recorded was counted both in laboratory and during in situ tests in the Sosnica mine. The WLIS apparatus does not cause the rock burst hazard to be rated lower than the rating obtained with the PAS-2 equipment. At low hazard levels the results are practically the same. At high hazard levels the WLIS apparatus records more pulses, however both instruments produce high ratings. The conclusion is reached that the criteria used with the PAS-2 apparatus can be used unchanged with the WLIS equipment. The WLIS apparatus has a detection threshold that adapts automatically to the actual noise and interference level, thus it can be used in more difficult conditions.

  14. J-PAS: The Javalambre-Physics of the Accelerated Universe Astrophysical Survey

    OpenAIRE

    Benitez, N.; Dupke, R.; Moles, M.; Sodre, L.; Cenarro, J.; Marin-Franch, A.; Taylor, K.; Cristobal, D.; Fernandez-Soto, A.; de Oliveira, C. Mendes; Cepa-Nogue, J.; Abramo, L. R.; Alcaniz, J. S.; Overzier, R.; Hernandez-Monteagudo, C.

    2014-01-01

    The Javalambre-Physics of the Accelerated Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Observatory in Spain with a purpose-built, dedicated 2.5m telescope and a 4.7 sq.deg. camera with 1.2Gpix. Starting in late 2015, J-PAS will observe 8500sq.deg. of Northern Sky and measure $0.003(1+z)$ photo-z for $9\\times10^7$ LRG and ELG galaxies plus several million QSOs, sampling an effective volume of $\\sim 14$ Gpc$^3$...

  15. Correlating the content and context of PAS 55 with the ISO 55000 series

    Directory of Open Access Journals (Sweden)

    Van den Honert, A. F.

    2013-08-01

    Full Text Available The ISO 55000 series is soon to supersede PAS 55 as the most recognised international standard for asset management. A correlation of the content and context of PAS 55 with the ISO 55000 series is required to assist organisations with the transition. After analysis of the structures, similarities, differences, and omissions of the two standards, a map was created to correlate the summarised content and context. The map established that, although both sets of standards have a similar structural framework, the ISO 55000 series is a more comprehensive and detailed standard, creating a clearer way to implement an asset management system within an organisation.

  16. 77 FR 61416 - Announcement of the Award of Single-Source Expansion Supplement Grants to Nine Personal...

    Science.gov (United States)

    2012-10-09

    ...'s Hospital Los Angeles Los Angeles CA 92,000.00 Cicatelli Associates Inc New York NY 65,000.00... HUMAN SERVICES Administration for Children and Families Announcement of the Award of Single-Source Expansion Supplement Grants to Nine Personal Responsibility Education Program Innovative Strategies (PREIS...

  17. Architecture of the soluble receptor Aer2 indicates an in-line mechanism for PAS and HAMP domain signaling.

    Science.gov (United States)

    Airola, Michael V; Huh, Doowon; Sukomon, Nattakan; Widom, Joanne; Sircar, Ria; Borbat, Peter P; Freed, Jack H; Watts, Kylie J; Crane, Brian R

    2013-03-11

    Bacterial receptors typically contain modular architectures with distinct functional domains that combine to send signals in response to stimuli. Although the properties of individual components have been investigated in many contexts, there is little information about how diverse sets of modules work together in full-length receptors. Here, we investigate the architecture of Aer2, a soluble gas-sensing receptor that has emerged as a model for PAS (Per-Arnt-Sim) and poly-HAMP (histidine kinase-adenylyl cyclase-methyl-accepting chemotaxis protein-phosphatase) domain signaling. The crystal structure of the heme-binding PAS domain in the ferric, ligand-free form, in comparison to the previously determined cyanide-bound state, identifies conformational changes induced by ligand binding that are likely essential for the signaling mechanism. Heme-pocket alternations share some similarities with the heme-based PAS sensors FixL and EcDOS but propagate to the Iβ strand in a manner predicted to alter PAS-PAS associations and the downstream HAMP junction within full-length Aer2. Small-angle X-ray scattering of PAS and poly-HAMP domain fragments of increasing complexity allow unambiguous domain assignments and reveal a linear quaternary structure. The Aer2 PAS dimeric crystal structure fits well within ab initio small-angle X-ray scattering molecular envelopes, and pulsed dipolar ESR measurements of inter-PAS distances confirm the crystallographic PAS arrangement within Aer2. Spectroscopic and pull-down assays fail to detect direct interactions between the PAS and HAMP domains. Overall, the Aer2 signaling mechanism differs from the Escherichia coli Aer paradigm, where side-on PAS-HAMP contacts are key. We propose an in-line model for Aer2 signaling, where ligand binding induces alterations in PAS domain structure and subunit association that is relayed through the poly-HAMP junction to downstream domains. Copyright © 2012 Elsevier Ltd. All rights reserved.

  18. Announcement: UEDA Heart Award for 2016.

    Science.gov (United States)

    2016-01-01

    We are pleased to announce that the following 4 articles have been selected for the the UEDA Heart Awards for the Year 2016.First PlaceDelivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Pulmonary Arterial HypertensionSatoshi Akagi, Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Hiromi Matsubara, Aiko Ogawa, Tetsuya Matoba, Kensuke Egashira, Hiroshi ItoInt Heart J 2015 ; 56(3) : 354-359Second PlaceVasopressin V2 Receptor Antagonist Tolvaptan Is Effective in Heart Failure Patients With Reduced Left Ventricular Systolic Function and Low Blood PressureSatoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Yukihiko Abe, Tomiyoshi Saito, Takayuki Ohwada, Hitoshi Suzuki, Shu-ichi Saitoh, Isao Kubota, Yasuchika Takeishi, on behalf of the AVCMA investigatorsInt Heart J 2015 ; 56(2) : 213-218Third PlaceWaon Therapy Improves Quality of Life as Well as Cardiac Function and Exercise Capacity in Patients With Chronic Heart FailureMitsuo Sobajima, Takashi Nozawa, Yasutaka Fukui, Hiroyuki Ihori, Takashi Ohori, Nozomu Fujii, Hiroshi InoueInt Heart J 2015 ; 56(2) : 203-208Association of Fish Consumption-Derived Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids and Cardiovascular Risk With the Prevalence of Coronary Artery Disease : A Cross-Sectional Pilot StudyShigemasa Tani, Atsuhiko Takahashi, Ken Nagao, Atsushi HirayamaInt Heart J 2015 ; 56(3) : 260-268November 2016International Heart Journal Association.

  19. [Cultural management of diagnosis announcement in ophthalmology].

    Science.gov (United States)

    Mancel Salino, E H

    2010-01-01

    There are important differences in the way cultures conceive diseases. The intercultural approach of diseases can enhance the ability of the medical staff to understand the patients' problems within their culture, to communicate medical explanations to the patients for better mutual comprehension, to alleviate patient's sufferings, to ensure compliance to follow up and treatment. We report the case of a multicultural approach for the announcement of a diagnosis of blindness for a baby with multiple diseases, in the course of visual electrophysiology clinics. This case shows the different possibilities of intercultural approach of diseases, with three levels of implication. At the first level we may acquire the knowledge of ethnologic tools to understand disease representations, types and causes that can be very different from the Western ones, in the patient's community. At the second level we may integrate cultural consciousness in the management of clinics. At the third level we may proceed to the cultural mediation of diseases. Practicing this intercultural approach of the patient develops the ethical part of the therapeutic relationship, it also provides the patients and the physicians better comfort, and better efficiency for prevention campaigns. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

  20. Programmable Logic Device (PLD) Design Description for the Integrated Power, Avionics, and Software (iPAS) Space Telecommunications Radio System (STRS) Radio

    Science.gov (United States)

    Shalkhauser, Mary Jo W.

    2017-01-01

    The Space Telecommunications Radio System (STRS) provides a common, consistent framework for software defined radios (SDRs) to abstract the application software from the radio platform hardware. The STRS standard aims to reduce the cost and risk of using complex, configurable and reprogrammable radio systems across NASA missions. To promote the use of the STRS architecture for future NASA advanced exploration missions, NASA Glenn Research Center (GRC) developed an STRS compliant SDR on a radio platform used by the Advance Exploration System program at the Johnson Space Center (JSC) in their Integrated Power, Avionics, and Software (iPAS) laboratory. At the conclusion of the development, the software and hardware description language (HDL) code was delivered to JSC for their use in their iPAS test bed to get hands-on experience with the STRS standard, and for development of their own STRS Waveforms on the now STRS compliant platform.The iPAS STRS Radio was implemented on the Reconfigurable, Intelligently-Adaptive Communication System (RIACS) platform, currently being used for radio development at JSC. The platform consists of a Xilinx ML605 Virtex-6 FPGA board, an Analog Devices FMCOMMS1-EBZ RF transceiver board, and an Embedded PC (Axiomtek eBox 620-110-FL) running the Ubuntu 12.4 operating system. Figure 1 shows the RIACS platform hardware. The result of this development is a very low cost STRS compliant platform that can be used for waveform developments for multiple applications.The purpose of this document is to describe the design of the HDL code for the FPGA portion of the iPAS STRS Radio particularly the design of the FPGA wrapper and the test waveform.

  1. Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal PAS domain protein 2 (NPAS2): conversion from His119/Cys170 coordination to His119/His171 coordination.

    Science.gov (United States)

    Uchida, Takeshi; Sagami, Ikuko; Shimizu, Toru; Ishimori, Koichiro; Kitagawa, Teizo

    2012-03-01

    Neuronal PAS domain protein 2 (NPAS2), which is a CO-dependent transcription factor, consists of a basic helix-loop-helix domain (bHLH), and two heme-containing PAS domains (PAS-A and PAS-B). In our previous study on the isolated PAS-A domain, we concluded that His119 and Cys170 are the axial ligands of the ferric heme, while Cys170 is replaced by His171 upon reduction of heme (Uchida et al., J. Biol. Chem. 270, (2005) 21358-21368.). Recently, we characterized the PAS-A domain combined with the N-terminal bHLH domain, and found that some spectroscopic features were different from those of the isolated PAS-A domain (Mukaiyama et al., FEBS J. 273, (2006) 2528-2539.). Therefore, we reinvestigated the coordination structure of heme in the bHLH-PAS-A domain and prepared four histidine and one cysteine mutants. Resonance Raman spectrum of the Cys170Ala mutant is the same as that of wild type with a dominant 6-coordinate heme in the ferric form. In contrast, His119Ala and His171Ala mutants significantly increase amounts of the 5-coordinate species, indicating that His119 and His171, not Cys170, are axial ligands of the ferric heme in the bHLH-PAS-A domain. We had confirmed that the coordination structure of the isolated PAS-A domain is in equilibrium between Cys-Fe-His and His-Fe-His coordinated species but newly found that interaction of the PAS-A domain with the bHLH domain shifts the equilibrium toward the latter structure. Such flexibility in the heme coordination structure seems to be in favor of signal transduction in NPAS2. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Crystal structure of the PAS domain of the hEAG potassium channel.

    Science.gov (United States)

    Tang, Xue; Shao, Juan; Qin, Xiaohong

    2016-08-01

    KCNH voltage-gated potassium channels play critical roles in regulating cellular functions. The channel is composed of four subunits, each of which contains six transmembrane helices forming the central pore. The cytoplasmic parts of the subunits present a Per-Arnt-Sim (PAS) domain at the N-terminus and a cyclic nucleotide-binding homology domain at the C-terminus. PAS domains are conserved from prokaryotes to eukaryotes and are involved in sensing signals and cellular responses. To better understand the functional roles of PAS domains in KCNH channels, the structure of this domain from the human ether-à-go-go channel (hEAG channel) was determined. By comparing it with the structures of the Homo sapiens EAG-related gene (hERG) channel and the Drosophila EAG-like K(+) (dELK) channel and analyzing the structural features of the hEAG channel, it was identified that a hydrophobic patch on the β-sheet may mediate interaction between the PAS domain and other regions of the channel to regulate its functions.

  3. Psychometric Properties and Norms of the German ABC-Community and PAS-ADD Checklist

    Science.gov (United States)

    Zeilinger, Elisabeth L.; Weber, Germain; Haveman, Meindert J.

    2011-01-01

    Aim: The aim of the present study was to standardize and generate psychometric evidence of the German language versions of two well-established English language mental health instruments: the "Aberrant Behavior Checklist-Community" (ABC-C) and the "Psychiatric Assessment Schedule for Adults with Developmental Disabilities" (PAS-ADD) Checklist. New…

  4. Whole-genome sequence of Starmerella bacillaris PAS13, a nonconventional enological yeast with antifungal activity

    DEFF Research Database (Denmark)

    Lemos Junior, Wilson Jose Fernandes; Treu, Laura; Duarte, Vinicius da Silva

    2017-01-01

    Starmerella bacillaris is a fermentative yeast commonly found in vineyards. Here, we present the draft genome sequence of S. bacillaris PAS13, a nonconventional enological yeast with a potential role as a biocontrol agent. This gene sequence will provide insights into the genetic basis of yeast a...... activity against gray mold disease (Botrytis cinerea)....

  5. Peer Relations and the Understanding of Faux Pas: Longitudinal Evidence for Bidirectional Associations

    Science.gov (United States)

    Banerjee, Robin; Watling, Dawn; Caputi, Marcella

    2011-01-01

    Research connecting children's understanding of mental states to their peer relations at school remains scarce. Previous work by the authors demonstrated that children's understanding of mental states in the context of a faux pas--a social blunder involving unintentional insult--is associated with concurrent peer rejection. The present report…

  6. Test report for PAS-1 cask certification for shipping payload B

    Energy Technology Data Exchange (ETDEWEB)

    MERCADO, J.E.

    1998-10-13

    This test report documents the successful inspection and testing to certify two NuPac PAS-1 casks in accordance with US Department of Energy Certificate of Compliance (CoC) USA/9184/B(U). The primary and secondary containment vessels of each cask met the acceptance criteria defined in the CoC and the test plan.

  7. Neuchatel ne gardera pas le Palais de l'equilibre apres Expo.02

    CERN Multimedia

    2002-01-01

    "La ville de Neuchatel ne souhaite pas conserver le Palais de l'equilibre apres Expo.02. Par 24 voix contre 7, le Conseil general a rejete le plan special du Conseil communal qui proposait de transformer l'edifice en un centre de congres" (1/2 page).

  8. DANTE announces new research and education link to India

    CERN Multimedia

    2006-01-01

    "Research networking organization DANTE (Delivery of Advanced Network Technology to Europe) has announced that high-speed communication links for students and researchers between India and Europe are now live." (1 page)

  9. Center for Global Health announces grants to support portable technologies

    Science.gov (United States)

    NCI's Center for Global Health announced grants that will support the development and validation of low-cost, portable technologies. These technologies have the potential to improve early detection, diagnosis, and non-invasive or minimally invasive treatm

  10. Vehicular regulations announced for Back Bay National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is an announcement pertaining to regulations published in the Federal Register concerning the Back Bay National Wildlife Refuge. The regulations all...

  11. PPARC announces £30m for physics Grid

    CERN Multimedia

    Maddock, Julia

    2007-01-01

    "Science computing in the UK has been boosted with the announcement by the Particle Physics and Astronomy Research Council (PPARC) of £30m further funding for the UK's largest scientific Grid." (2/3 page)

  12. J-PAS: The Javalambre Physics of the Accelerated Universe Astrophysical Survey

    Science.gov (United States)

    Cepa, J.; Benítez, N.; Dupke, R.; Moles, M.; Sodré, L.; Cenarro, A. J.; Marín-Franch, A.; Taylor, K.; Cristóbal, D.; Fernández-Soto, A.; Mendes de Oliveira, C.; Abramo, L. R.; Alcaniz, J. S.; Overzier, R.; Hernández-Monteagudo, A.; Alfaro, E. J.; Kanaan, A.; Carvano, M.; Reis, R. R. R.; J-PAS Team

    2016-10-01

    The Javalambre Physics of the Accelerated Universe Astrophysical Survey (J-PAS) is a narrow band, very wide field Cosmological Survey to be carried out from the Javalambre Observatory in Spain with a purpose-built, dedicated 2.5 m telescope and a 4.7 sq.deg. camera with 1.2 Gpix. Starting in late 2016, J-PAS will observe 8500 sq.deg. of Northern Sky and measure Δz˜0.003(1+z) photo-z for 9× 107 LRG and ELG galaxies plus several million QSOs, sampling an effective volume of ˜ 14 Gpc3 up to z=1.3 and becoming the first radial BAO experiment to reach Stage IV. J-PAS will detect 7× 105 galaxy clusters and groups, setting constraints on Dark Energy which rival those obtained from its BAO measurements. Thanks to the superb characteristics of the site (seeing ˜ 0.7 arcsec), J-PAS is expected to obtain a deep, sub-arcsec image of the Northern sky, which combined with its unique photo-z precision will produce one of the most powerful cosmological lensing surveys before the arrival of Euclid. J-PAS's unprecedented spectral time domain information will enable a self-contained SN survey that, without the need for external spectroscopic follow-up, will detect, classify and measure σz˜ 0.5 redshifts for ˜ 4000 SNeIa and ˜ 900 core-collapse SNe. The key to the J-PAS potential is its innovative approach: a contiguous system of 54 filters with 145 Å width, placed 100 Å apart over a multi-degree FoV is a powerful redshift machine, with the survey speed of a 4000 multiplexing low resolution spectrograph, but many times cheaper and much faster to build. The J-PAS camera is equivalent to a 4.7 sq.deg. IFU and it will produce a time-resolved, 3D image of the Northern Sky with a very wide range of Astrophysical applications in Galaxy Evolution, the nearby Universe and the study of resolved stellar populations.

  13. Characterization of the PAS domain in the sensor-kinase BvgS: mechanical role in signal transmission.

    Science.gov (United States)

    Dupré, Elian; Wohlkonig, Alexandre; Herrou, Julien; Locht, Camille; Jacob-Dubuisson, Françoise; Antoine, Rudy

    2013-07-24

    In bacteria, signal-transduction two-component systems are major players for adaptation to environmental stimuli. The perception of a chemical or physical signal by a sensor-kinase triggers its autophosphorylation. The phosphoryl group is then transferred to the cognate response regulator, which mediates the appropriate adaptive response. Virulence of the whooping cough agent Bordetella pertussis is controlled by the two-component system BvgAS. Atypically, the sensor-kinase BvgS is active without specific stimuli at 37°C in laboratory conditions and is inactivated by the addition of negative chemical modulators. The structure of BvgS is complex, with two tandem periplasmic Venus flytrap domains and a cytoplasmic PAS domain that precedes the kinase domain, which is followed by additional phosphotransfer domains. PAS domains are small, ubiquitous sensing or regulatory domains. The function of the PAS domain in BvgS remains unknown. We showed that recombinant BvgS PAS proteins form dimers that are stabilized by α helical regions flanking the PAS core. A structural model of the PAS domain dimer was built and probed by site-directed mutagenesis and by biochemical and functional analyses. Although we found no ligands for the PAS domain cavity, its integrity is required for signaling. We also showed that the structural stability of the PAS core and its proper coupling to its flanking N- and C-terminal α helices are crucial for BvgS activity. We propose that a major function of the BvgS PAS domain is to maintain conformational signals arising from mechanical strain generated by the periplasmic domain. The tight structure of the PAS core and its connections with the upstream and downstream helices ensure signaling to the kinase domain, which determines BvgS activity. Many mild substitutions that map to the PAS domain keep BvgS active but make it unresponsive to negative modulators, supporting that modulation increases conformational strain in the protein.

  14. Share price reaction to earnings announcement on the JSE-ALtX: A ...

    African Journals Online (AJOL)

    efficient market hypothesis, earnings announcement, capital asset pricing model, post-earnings announcement drift, ... of testing this concept has been the observation of stock market reaction to corporate announcements. ..... that made multiple announcements during the 16-day event period are excluded from the sample.

  15. Does Faux Pas Detection in Adult Autism Reflect Differences in Social Cognition or Decision-Making Abilities?

    Science.gov (United States)

    Thiébaut, Flora I.; White, Sarah J.; Walsh, Annabel; Klargaard, Solja K.; Wu, Hsuan-Chen; Rees, Geraint; Burgess, Paul W.

    2016-01-01

    43 typically-developed adults and 35 adults with ASD performed a cartoon faux pas test. Adults with ASD apparently over-detected faux pas despite good comprehension abilities, and were generally slower at responding. Signal detection analysis demonstrated that the ASD participants had significantly greater difficulty detecting whether a cartoon…

  16. Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR

    Science.gov (United States)

    Hao, Nan; Whitelaw, Murray L.; Shearwin, Keith E.; Dodd, Ian B.; Chapman-Smith, Anne

    2011-01-01

    The basic helix–loop–helix (bHLH).PAS dimeric transcription factors have crucial roles in development, stress response, oxygen homeostasis and neurogenesis. Their target gene specificity depends in part on partner protein choices, where dimerization with common partner Aryl hydrocarbon receptor nuclear translocator (Arnt) is an essential step towards forming active, DNA binding complexes. Using a new bacterial two-hybrid system that selects for loss of protein interactions, we have identified 22 amino acids in the N-terminal PAS domain of Arnt that are involved in heterodimerization with aryl hydrocarbon receptor (AhR). Of these, Arnt E163 and Arnt S190 were selective for the AhR/Arnt interaction, since mutations at these positions had little effect on Arnt dimerization with other bHLH.PAS partners, while substitution of Arnt D217 affected the interaction with both AhR and hypoxia inducible factor-1α but not with single minded 1 and 2 or neuronal PAS4. Arnt uses the same face of the N-terminal PAS domain for homo- and heterodimerization and mutational analysis of AhR demonstrated that the equivalent region is used by AhR when dimerizing with Arnt. These interfaces differ from the PAS β-scaffold surfaces used for dimerization between the C-terminal PAS domains of hypoxia inducible factor-2α and Arnt, commonly used for PAS domain interactions. PMID:21245039

  17. Dose regimen of para-aminosalicylic acid gastro-resistant formulation (PAS-GR) in multidrug-resistant tuberculosis.

    Science.gov (United States)

    Kibleur, Yves; Brochart, Hervé; Schaaf, Hendrik S; Diacon, Andre H; Donald, Peter R

    2014-04-01

    Resurgence of multidrug-resistant tuberculosis (MDR-TB) has raised a renewed interest in para-aminosalicylic acid (PAS) and other efficacious drugs. A gastro-resistant granule formulation (PAS-GR) was designed to be better tolerated than earlier forms of PAS, with fewer adverse effects from reduced production of meta-aminophenol. PAS release from PAS-GR granules is slower than with earlier formulations. Pharmacokinetic data are, however, limited and only a few studies have assisted in defining the best PAS-GR dose regimen. Interest in refining the latter continues and recent data contributed in better defining the optimal PAS-GR dose regimen in adults and children. The present paper draws on these recent studies, synthesizes pharmacokinetic results from different population groups, and draws comparisons with in vitro data and the results of earlier pharmacokinetic studies in order to discuss the most appropriate dosing regimen for PAS-GR. A comparative in vitro dissolution study was carried out with a 1 g acid PAS equivalent of various formulations of PAS and PAS-GR and in vitro-in vivo correlations. Retrospective comparisons between recent and earlier clinical studies were also gathered to clarify the dose regimen of PAS-GR in adults and children. Exposure after a 4 g twice- or three times daily dose regimen in adult MDR-TB patients confirmed that both dose regimens can be used. The twice-daily dose regimen does not, however, confer any safety margin over the potentiality of "too" high plasma concentrations after a three times daily dose regimen and may lead to under-dosage when a dose is missed, as compliance often decreases over time. Based on available data and practical considerations, a 4 g three times daily dose regimen of PAS-GR should be the preferred dose in hospital settings, where it remains the best regimen to cover the around-the-clock suppression of mycobacteria based on the minimal inhibitory concentration for PAS. In MDR-TB adults and in hospital

  18. 76 FR 47296 - Transit Asset Management (TAM) Pilot Program Funds

    Science.gov (United States)

    2011-08-04

    ... Federal Transit Administration Transit Asset Management (TAM) Pilot Program Funds AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Transit Asset Management Pilot Program Announcement of Project Selections... the Transit Asset Management (TAM) Pilot Program, which was announced in the TAM Program Notice of...

  19. SELECTED REQUIREMENTS OF INTEGRATED MANAGEMENT SYSTEMS BASED ON PAS 99 SPECIFICATION

    Directory of Open Access Journals (Sweden)

    Paweł Nowicki

    2013-03-01

    Full Text Available The aim this research was to analyze the ways of integration of management systems in food sector. The study involved the documentation, audits, corrective and preventive actions and management's review phases described in the specification PAS 99, which is one of common elements of integrated management systems. Four organizations were selected for the study. The organizations had introduced and certified at least two standardized management systems. It was assumed that the investigated organizations should have implemented the HACCP system. Studies were conducted as a case study. The employees responsible for the functioning of management systems were interviewed in all four organizations. The study was conducted in the form of in-depth interviews based on pre-prepared script. The scenario was developed based on the PAS 99 guideline. The process of integration of management systems implemented in the studied companies reveals the full compliance of an integrated management system with PASS 99 in the policy area.

  20. Balanced ScoreCard Y las Normas de Integración PAS 99:2006

    Directory of Open Access Journals (Sweden)

    Soler González, Rafael H.

    2013-12-01

    Full Text Available For the development of this work the authors used the Norton & Kaplan recommendations for the implementation of the Balanced Scorecard (BSC, and novel diagnostic tools as SISTRAT, strategy maps software for LINUX UBUNTU DC Map.xls and development of Box Mando. Once the BSC was implemented, a longitudinal study of data in the scorecard was carried out in order to analyze to what extent the implementation of the BSC in the Design and Engineering Company (EDIN coincided with the seven principles of integration standards PAS 99:2006. For this comparison Hamming´s relative distances were used as a measurement tool. Respective analyzes were performed to the extent that the relative distances were declining which showed that the BSC implemented in EDIN was consistent with PAS 99:2006.

  1. 1 1) Pourquoi est-ce que je ne parviens pas à ouvrir les formulaires ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    compte des questions comme celles de l'utilisation et des pratiques sont les bienvenues. e) La troisième incidence visée par les Partenariats canadiens ayant trait à l'apprentissage, le programme invite les candidats à sortir de leur zone de confort lorsqu'ils réfléchiront à cet aspect. Il n'est pas question ici des constatations ...

  2. , TOUCHE PAS À MA TERRE, I ! ' C'EST MA VIE !

    International Development Research Centre (IDRC) Digital Library (Canada)

    ce phénomène sur les sociétés locales, à savoir, les risques de multiplication des conflits dans les zones touchées, la perte des moyens de subsistance des populations riveraines et la perturbation de la vie socio-économique et culturelle. C'est suite à ces constats qu'est né le slogan : «Touche pas à ma terre, c'est ma vie !

  3. Pied de Charcot: un diagnostic à ne pas méconnaitre | Khammassi ...

    African Journals Online (AJOL)

    A l'examen clinique on notait un pied droit déformé, indolore, tuméfié dans sa globalité avec une augmentation importante du son volume et un lymphoedème de la jambe. Par ailleurs il n'y avait pas de signes inflammatoires ni fluctuation. La biologie montrait une glycémie élevée (entre 3 et 4 g/l) sans syndrome ...

  4. Practical Analysis of materials with depth varying compositions using FT-IR photoacoustic spectroscopy (PAS)

    Energy Technology Data Exchange (ETDEWEB)

    J.F. McClelland; R.W. Jones; Siquan Luo

    2004-09-30

    FT-IR photoacoustic spectroscopy (PAS) is discussed as a nondestructive method to probe the molecular composition of materials versus depth on the basis of the analysis of layers of experimentally controllable thickness, which are measured from the sample surface to depths of some tens of micrometers, depending on optical and thermal properties. Computational methods are described to process photoacoustic amplitude and phase spectra for both semi-quantitative and quantitative depth analyses. These methods are demonstrated on layered and gradient samples.

  5. A study on N2O measurement characteristics using photoacoustic spectroscopy (PAS).

    Science.gov (United States)

    Kang, Soyoung; Kim, Seoungjin; Kang, Seongmin; Lee, Jeongwoo; Cho, Chang-Sang; Sa, Jea-Hwan; Jeon, Eui-Chan

    2014-08-07

    N2O, which is emitted mainly from nitrogen decomposition via bacteria, livestock manure, agricultural fertilizer use, fossil fuel combustion and waste incineration, is classified as a substance that causes significant destruction of the ozone layer. The N2O measurement methods for these emission sources may be divided into chromatography, optical, and electrical current measurements. Chromatography has been widely utilized for analyzing N2O. However, up until now, few studies have been conducted on N2O using photoacoustic spectroscopy. Therefore, this study aimed to evaluate performance of photoacoustic spectroscopy in this regard based on laboratory and field test results. The repeatability of photoacoustic spectroscopy was measured at 1.12%, which is lower than the repeatability of 3.0% suggested by the ISO 1564 standard, so, it has shown an excellent repeatability. The detection limit was determined to be 0.025 ppm, and the response time was confirmed to be 3 min and 26 s. The results of comparison between these measurements and GC show that the latter has superior accuracy, but mobility and convenience are superior for PAS. On the contrary, GC has a continuous measurement limitation, but PAS makes it possible to conduct continuous measurements. Therefore, PAS can be extremely useful to confirm the characteristics of N2O emissions and to quantify their amount.

  6. A Study on N2O Measurement Characteristics Using Photoacoustic Spectroscopy (PAS

    Directory of Open Access Journals (Sweden)

    Soyoung Kang

    2014-08-01

    Full Text Available N2O, which is emitted mainly from nitrogen decomposition via bacteria, livestock manure, agricultural fertilizer use, fossil fuel combustion and waste incineration, is classified as a substance that causes significant destruction of the ozone layer. The N2O measurement methods for these emission sources may be divided into chromatography, optical, and electrical current measurements. Chromatography has been widely utilized for analyzing N2O. However, up until now, few studies have been conducted on N2O using photoacoustic spectroscopy. Therefore, this study aimed to evaluate performance of photoacoustic spectroscopy in this regard based on laboratory and field test results. The repeatability of photoacoustic spectroscopy was measured at 1.12%, which is lower than the repeatability of 3.0% suggested by the ISO 1564 standard, so, it has shown an excellent repeatability. The detection limit was determined to be 0.025 ppm, and the response time was confirmed to be 3 min and 26 s. The results of comparison between these measurements and GC show that the latter has superior accuracy, but mobility and convenience are superior for PAS. On the contrary, GC has a continuous measurement limitation, but PAS makes it possible to conduct continuous measurements. Therefore, PAS can be extremely useful to confirm the characteristics of N2O emissions and to quantify their amount.

  7. A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues

    Science.gov (United States)

    Mann, Thomas H.; Seth Childers, W.; Blair, Jimmy A.; Eckart, Michael R.; Shapiro, Lucy

    2016-01-01

    All cells must integrate sensory information to coordinate developmental events in space and time. The bacterium Caulobacter crescentus uses two-component phospho-signalling to regulate spatially distinct cell cycle events through the master regulator CtrA. Here, we report that CckA, the histidine kinase upstream of CtrA, employs a tandem-PAS domain sensor to integrate two distinct spatiotemporal signals. Using CckA reconstituted on liposomes, we show that one PAS domain modulates kinase activity in a CckA density-dependent manner, mimicking the stimulation of CckA kinase activity that occurs on its transition from diffuse to densely packed at the cell poles. The second PAS domain interacts with the asymmetrically partitioned second messenger cyclic-di-GMP, inhibiting kinase activity while stimulating phosphatase activity, consistent with the selective inactivation of CtrA in the incipient stalked cell compartment. The integration of these spatially and temporally regulated signalling events within a single signalling receptor enables robust orchestration of cell-type-specific gene regulation. PMID:27117914

  8. [Parental alienation syndrome (PAS): unknown in medical settings, endemic in courts].

    Science.gov (United States)

    Pignotti, Maria Serenella

    2013-02-01

    A purposed syndrome of so-called parental alienation (PAS), unsupported by any evidence-based data, unknown in medical settings, unquoted in medical books, absent in DSM and ICD, never demonstrated by controlled studies published in high scientific level journals, is rampant in Courts where it can lead to loose parental custody. During a divorce trial, almost always the mothers and the children, become joint in a sort of folie au deux, in a denigration campaign of ex-husband/father. From a review on this issue it seems evident its theoretical roots lie on a theory that justify gender violence and children sexual abuse. The bias that both of them are layers and that he children have not autonomy block their possibility of any defence in front of a Court. In severe cases, PAS becomes a new and efficient tool of intra-familiar violence. The treatment of severe cases is to stop any contact between mother and children. The resort to PAS in Courts must be strongly rejected.

  9. Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain.

    Science.gov (United States)

    Harley, Carol A; Starek, Greg; Jones, David K; Fernandes, Andreia S; Robertson, Gail A; Morais-Cabral, João H

    2016-08-30

    The human human ether-à-go-go-related gene (hERG) potassium channel plays a critical role in the repolarization of the cardiac action potential. Changes in hERG channel function underlie long QT syndrome (LQTS) and are associated with cardiac arrhythmias and sudden death. A striking feature of this channel and KCNH channels in general is the presence of an N-terminal Per-Arnt-Sim (PAS) domain. In other proteins, PAS domains bind ligands and modulate effector domains. However, the PAS domains of KCNH channels are orphan receptors. We have uncovered a family of positive modulators of hERG that specifically bind to the PAS domain. We generated two single-chain variable fragments (scFvs) that recognize different epitopes on the PAS domain. Both antibodies increase the rate of deactivation but have different effects on channel activation and inactivation. Importantly, we show that both antibodies, on binding to the PAS domain, increase the total amount of current that permeates the channel during a ventricular action potential and significantly reduce the action potential duration recorded in human cardiomyocytes. Overall, these molecules constitute a previously unidentified class of positive modulators and establish that allosteric modulation of hERG channel function through ligand binding to the PAS domain can be attained.

  10. Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

    Science.gov (United States)

    Partch, Carrie L; Gardner, Kevin H

    2011-05-10

    Hypoxia-inducible factor (HIF) is the key transcriptional effector of the hypoxia response in eukaryotes, coordinating the expression of genes involved in oxygen transport, glycolysis, and angiogenesis to promote adaptation to low oxygen levels. HIF is a basic helix-loop-helix (bHLH)-PAS (PER-ARNT-SIM) heterodimer composed of an oxygen-labile HIF-α subunit and a constitutively expressed aryl hydrocarbon receptor nuclear translocator (ARNT) subunit, which dimerize via basic helix-loop-helix and PAS domains, and recruit coactivators via HIF-α C-terminal transactivation domains. Here we demonstrate that the ARNT PAS-B domain provides an additional recruitment site by binding the coactivator transforming acidic coiled-coil 3 (TACC3) in a step necessary for transcriptional responses to hypoxia. Structural insights from NMR spectroscopy illustrate how this PAS domain simultaneously mediates interactions with HIF-α and TACC3. Finally, mutations on ARNT PAS-B modulate coactivator selectivity and target gene induction by HIF in vivo, demonstrating a bifunctional role for transcriptional regulation by PAS domains within bHLH-PAS transcription factors.

  11. Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1.

    Science.gov (United States)

    Etto, Tamara; de Boer, Carmela; Prickett, Sara; Gardner, Leanne M; Voskamp, Astrid; Davies, Janet M; O'Hehir, Robyn E; Rolland, Jennifer M

    2012-01-01

    Bahia grass pollen (BaGP) is a major cause of allergic rhinitis. Subcutaneous allergen-specific immunotherapy is effective for grass pollen allergy, but is unsuitable for patients with moderate to severe asthma due to the risk of anaphylaxis. T cell-reactive but IgE nonreactive peptides provide a safer treatment option. This study aimed to identify and characterize dominant CD4(+) T cell epitope peptides of the major BaGP allergen, Pas n 1. Pas n 1-specific T cell lines generated from the peripheral blood of BaGP-allergic subjects were tested for proliferative and cytokine response to overlapping 20-mer Pas n 1 peptides. Cross-reactivity to homologous peptides from Lol p 1 and Cyn d 1 of Ryegrass and Bermuda grass pollen, respectively, was assessed using Pas n 1 peptide-specific T cell clones. MHC class II restriction of Pas n 1 peptide T cell recognition was determined by HLA blocking assays and peptide IgE reactivity tested by dot blotting. Three Pas n 1 peptides showed dominant T cell reactivity; 15 of 18 (83%) patients responded to one or more of these peptides. T cell clones specific for dominant Pas n 1 peptides showed evidence of species-specific T cell reactivity as well as cross-reactivity with other group 1 grass pollen allergens. The dominant Pas n 1 T cell epitope peptides showed HLA binding diversity and were non-IgE reactive. The immunodominant T cell-reactive Pas n 1 peptides are candidates for safe immunotherapy for individuals, including those with asthma, who are allergic to Bahia and possibly other grass pollens. Copyright © 2012 S. Karger AG, Basel.

  12. Patency of Saphenous Vein Grafts Using the PAS-Port System During Coronary Artery Bypass Surgery.

    Science.gov (United States)

    Kubota, Hiroshi; Endo, Hidehito; Ishii, Hikaru; Tsuchiya, Hiroshi; Takahashi, Yu; Inaba, Yusuke; Noma, Mio; Yoshimoto, Akihiro; Higuchi, Satoshi; Kohshoh, Hideyasu; Taniai, Seiichi; Ishiguro, Haruhisa; Yoshino, Hideaki; Sudo, Kenichi

    2017-08-01

    Several proximal anastomosis devices have been developed to shorten the time required for a proximal anastomosis and to avoid aortic cross-/side-clamping during coronary artery bypass grafting. This study retrospectively examined the patency of saphenous vein grafts (SVGs) using the PAS-Port System (Cardia Inc, Redwood City, CA). From 2004 to 2014, 451 patients underwent coronary artery bypass graft operations requiring at least 1 proximal anastomosis using a PAS-Port device. A total of 802 PAS-Port devices were used, and 95.0% (762 of 802) were implanted successfully. Among the successfully implanted anastomoses, 76.8% (585 of 762) were evaluated using coronary angiography or multidimensional computed tomography, or both. The evaluations were performed between postoperative days 4 and 3,182 (mean, 319 ± 624 days). The early (1 to 365 days) and the midterm to long-term (more than 366 days) occlusion rates were examined. A complete postoperative clinical course was recorded for 70.7% of the patients. Overall, 93.8% (549 of 585) of the device-dependent SVGs were patent. The patency rates of device-dependent SVGs that were 1, 2, 3, 4, 5, 6, 7, and 8 years old were 90.1% ± 1.8%, 87.1% ± 2.3%, 86.1% ± 2.5%, 82.9% ± 3.3%, 80.6% ± 3.9%, 77.2% ± 5.0%, 77.2% ± 5.0%, and 70.2% ± 8.1%, respectively. The longest follow-up period was 3,182 days (8.7 years). The occlusion rate for device-dependent SVGs tended to decrease as the number of patients accumulated. The PAS-Port system provided acceptable SVG patency and clinical outcome for the early and midterm to long-term. There may be a learning curve for the use of PAS-Port device that affects the device-dependent SVG patency. Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  13. Existence Conditions and Formation Process of Second Type of Spiral Loop Particle Accumulation Structure (SL-2 PAS) in Half-zone Liquid Bridge

    Science.gov (United States)

    Toyama, A.; Gotoda, M.; Kaneko, T.; Ueno, I.

    2017-08-01

    We focus on unique phenomena known as particle accumulation structure (PAS), especially on the conditions of the existence for second-type spiral loop PAS (SL-2 PAS) and on their formation processes under normal gravity. We investigate the existence conditions as functions the aspect ratio of the liquid bridge and the Marangoni number, the intensity of the thermocapillary effect. We discuss the differences among SL-1 PAS, SL-2 PAS and the flow field without PAS through observation of the solid-like structures of the PAS in a rotating frame of reference with the hydrothermal wave, and through monitoring of the surface temperature by infrared camera. We evaluate the formation time of PAS by employing a modified accumulation measure by considering the effect of the particles' size.

  14. Standardized staining methods: Feulgen-Rossenbeck reaction for desoxyribonucleic acid and periodic acid-Schiff (PAS) procedure

    DEFF Research Database (Denmark)

    Lyon, H O; Schulte, E K; Prento, P

    2002-01-01

    A project group working under the European Confederation of Laboratory Medicine (ECLM) presents recommendations for standardized procedures for the Feulgen-Rossenbeck-Schiff and the periodic acid-Schiff (PAS) reactions on cytological and histological material. The advantages and disadvantages...

  15. Lord Sainsbury announces outcome of Research Council review

    CERN Multimedia

    Dept. Trade & Industry

    2002-01-01

    Science and Innovation Minister, Lord Sainsbury, today announced the outcome of a review of the Council for the Central Laboratory of the Research Councils (CCLRC). The report is the second stage of a five-yearly review, which outlines ways to strengthen and promote greater value for money from the UK's investment in science (1 page).

  16. ATLAS Collaboration Reaction to 2013 Physics Nobel Prize Announcement

    CERN Multimedia

    Abdeslam Hoummada

    2013-01-01

    Physicists from ATLAS took a brief time out from their collaboration week in Marrakech, Morocco to watch the announcement of the Nobel Prize in Physics for 2013. To their delight, it was awarded to Francois Englert and Peter Higgs for their pioneering work on the electroweak-symmetry-breaking mechanism in 1964.

  17. An analysis of flight announcers' language at the Murtala ...

    African Journals Online (AJOL)

    Output of the reading test was recorded, phonetically transcribed and analyzed using descriptive statistics. The result showed that exposure to native speakers, age of respondents and years of working experience, affects correct pronunciation. It also showed that most flight announcers approximate the English phonemes ...

  18. Oracle announces increased uptake of Oracle9i Application Server

    CERN Multimedia

    2002-01-01

    Oracle Europe this week announced that increasingly, companies in the region are selecting the Oracle9i Application Server (Oracle9iAS) to develop and deploy web-based business application. CERN is one of its customers (1/2 page).

  19. Evaluating impact of truck announcements on container stacking efficiency

    NARCIS (Netherlands)

    E. van Asperen (Eelco); B. Borgman (Bram); R. Dekker (Rommert)

    2013-01-01

    textabstractContainer stacking rules are an important factor in container terminal efficiency. We build on prior research and use a discrete-event simulation model to evaluate the impact of a truck announcement system on the performance of online container stacking rules. The information that is

  20. Information and Announcements Science Academies 81st Refresher ...

    Indian Academy of Sciences (India)

    IAS Admin

    2016-09-25

    Sep 25, 2016 ... ANN. RESONANCE | September 2016. Information and Announcements. Science Academies 81st Refresher Course on. Experimental Physics. 3–18, November 2016. Goa University, Goa. A Refresher Course in Experimental Physics will be held at Goa University, Goa from 03 to 18 November 2016 for.

  1. Information and Announcements Refresher Course in 'Topics in ...

    Indian Academy of Sciences (India)

    Information and Announcements. Refresher Course in 'Topics in. Mathematics and Physics'. May 14-26,2007 sponsored by Indian ... transforms; probability theory, random walks, and statistics; topics in diffusion, electromag- netism, and mechanics; and topics in statistical mechanics, quantum mechanics, and thermo-.

  2. 76 FR 16409 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-03-23

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Lock+ Hydro Friends Fund XXXIV... random drawing to determine the filing priority of the applicants identified in this notice. The...\\ The priority established by this drawing will be used to determine which applicant, among those with...

  3. 77 FR 9915 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2012-02-21

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Lock+ Hydro Friends Fund XLI... conduct a random drawing to determine the filing priority of the applicants identified in this notice. The...\\ The priority established by this drawing will be used to determine which applicant, among those with...

  4. 76 FR 16408 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-03-23

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Lock+ Hydro Friends Fund XXXVII... Secretary of the Commission, or her designee, will conduct a random drawing to determine the filing priority... applications as provided in section 4.37 of its regulations.\\2\\ The priority established by this drawing will...

  5. 77 FR 24197 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2012-04-23

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Mississippi 8 Hydro, LLC... drawing to determine the filing priority of the applicants identified in this notice. The Commission will... priority established by this drawing will be used to determine which applicant, among those with identical...

  6. 76 FR 16406 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-03-23

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing ] Lock+ Hydro Friends Fund... random drawing to determine the filing priority of the applicants identified in this notice. The...\\ The priority established by this drawing will be used to determine which applicant, among those with...

  7. 76 FR 4894 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-01-27

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing January 20, 2011. Lock Hydro... Commission, or her designee, will, by random drawing, determine the filing priority for the two applicants identified in this notice. The drawing is open to the public and will be held in room 2C, the Commission...

  8. 75 FR 32459 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2010-06-08

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing May 28, 2010. In the matter of... Commission, or her designee, will, by random drawing, determine the filing priority for the two applicants identified in this notice. The drawing is open to the public and will be held in room 2C, the Commission...

  9. 76 FR 4893 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-01-27

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing January 20, 2011. Lock Hydro..., at 10 a.m. (eastern time), the Secretary of the Commission, or her designee, will, by random drawing, determine the filing priority for the three applicants identified in this notice. The drawing is open to the...

  10. 76 FR 15972 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-03-22

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Project No. Lock+ Hydro Friends... designee, will conduct a random drawing to determine the filing priority of the applicants identified in... of its regulations.\\2\\ The priority established by this drawing will be used to determine which...

  11. 76 FR 16407 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2011-03-23

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Lock+ Hydro Friends Fund XLVI... random drawing to determine the filing priority of the applicants identified in this notice. The...\\ The priority established by this drawing will be used to determine which applicant, among those with...

  12. 77 FR 10739 - Notice Announcing Preliminary Permit Drawing

    Science.gov (United States)

    2012-02-23

    ... Energy Regulatory Commission Notice Announcing Preliminary Permit Drawing Project No. FFP Project 91, LLC... Secretary of the Commission, or her designee, will conduct a random drawing to determine the filing priority... applications as provided in section 4.37 of its regulations.\\2\\ The priority established by this drawing will...

  13. 48 CFR 2035.71 - Broad agency announcements.

    Science.gov (United States)

    2010-10-01

    ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.71 Broad agency announcements. (a..., approaches, or concepts demonstrated by the proposal. (2) Overall scientific, technical, or economic merits... unique combinations of these which are integral factors for achieving the proposal objectives. (4) The...

  14. 77 FR 67439 - Fiscal Year 2013 Public Transportation on Indian Reservations Program

    Science.gov (United States)

    2012-11-09

    ... Federal Transit Administration Fiscal Year 2013 Public Transportation on Indian Reservations Program.... SUMMARY: This notice announces changes in the Public Transportation on Indian Reservations program (Tribal... Public Transportation on Indian Reservations Program (Tribal Transit Program). The program authorized...

  15. JPCam: Status of the 1.2Gpixel camera for the J-PAS survey.

    Science.gov (United States)

    Taylor, Keith; Marín-Franch, Antonio; Santoro, Fernando; Mendes de Oliveira, Claudia; Dupke, Renato

    2015-08-01

    JPCam is a 14-CCD mosaic camera, using the new e2v 9k-by-9k, 10 micron pixel detectors, to be deployed on the JST/T250, a dedicated 2.55m wide-field telescope at the OAJ (Observatorio Astrofísico de Javalambre) in Teruel, Spain. The camera is designed to perform the J-PAS, a BAO survey of the northern sky. The J-PAS survey strategy will use 59 filters, 56 relatively narrow-band (14.5nm) filters equi-spaced between 350 and 1000nm plus 3 broad-band filters to achieve unprecedented photometric red-shift accuracies for faint galaxies over 8000 square degrees of sky. The cryostat, detector mosaic and read electronics is being supplied by e2v. Each science detector is read from 16 ports simultaneously, allowing read times of 14s with a typical read noise of 5e- (rms). The JPCam focal plane will be complemented with 4 autoguiding and 8 wavefront sensing CCDs. Image quality over the whole CCD mosaic will be maintained by applying the required, close loop, focus, tilt and rotation adjustments to the focal plane through the JPCam hexapod actuator system, manufactured by NTE-Sener. The filter unit has been designed to admit 5 filter trays, each mounting 14 filters corresponding to the 14 CCDs of the mosaic. Each CCD will view only its corresponding filter avoiding optical cross-talk from their neighbors. With this configuration, JPCam will cover 4.7 square degrees with a plate scale of 0.2267 arcsec/pix and will allow all the J-PAS filters to be permanently installed on the camera. The massive 525mm aperture shutter is supplied by Bonn-Shutter UG.

  16. Le big bang n'est pas une théorie comme les autres

    CERN Document Server

    Bonnet-Bidaud, Jean-Marc; Leglu, Dominique; Reinisch, Gilbert

    2009-01-01

    Le big bang n'est pas une théorie comme les autres. Ce n'est d'ailleurs pas une théorie physique au sens propre du terme, mais un scénario cosmologique issu des équations de la relativité générale. Il est le modèle qui s'ajuste le mieux aux observations actuelles, mais à quel prix ? Il nous livre un Univers composé à 96 % de matière et d'énergie noires inconnues. C'est donc un euphémisme que de dire que le big bang semble poser autant - sinon plus - de questions qu'il n'en résout. En ce sens, le big bang apparaît davantage comme une paramétrisation de notre ignorance plutôt que comme une modélisation d'un phénomène. Pourtant, le succès du big bang et l'adhésion qu'il suscite, tant dans la sphère scientifique que dans la sphère médiatique, ne se démentent pas. Surmédiatisé, son statut dépasse celui de modèle théorique, et la simple évocation de son nom suffit pour justifier des opérations de marketing scientifique ou rejeter des cosmologies alternatives. Pour éclaircir les pr...

  17. Second Annual Maintenance, Inspection, and Test Report for PAS-1 Cask Certification for Shipping Payload B

    Energy Technology Data Exchange (ETDEWEB)

    KELLY, D.J.

    2000-10-09

    The Nuclear Packaging, Inc. (NuPac), PAS-1 cask is required to undergo annual maintenance and inspections to retain certification in accordance with U.S. Department of Energy (DOE) Certificate of Compliance USA/9184B(U) (Appendix A). The packaging configuration being tested and maintained is the NuPac PAS-1 cask for Payload B. The intent of the maintenance and inspections is to ensure the packaging remains in unimpaired physical condition. Two casks, serial numbers 2162-026 and 2162-027, were maintained, inspected, and tested at the 306E Development, Fabrication, and Test Laboratory, located at the Hanford Site's 300 Area. Waste Management Federal Services, Inc. (WMFS), a subsidiary of GTS Duratek, was in charge of the maintenance and testing. Cogema Engineering Corporation (Cogema) directed the operations in the test facility. The maintenance, testing, and inspections were conducted successfully with both PAS-1 casks. The work conducted on the overpacks included weighing, gasket replacement, and plastic pipe plug and foam inspections. The work conducted on the secondary containment vessel (SCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, and a helium leak test. The work conducted on the primary containment vessel (PCV) consisted of visual inspection of the vessel and threaded parts (i.e., fasteners), visual inspection of sealing surfaces, replacement of O-ring seals, dimensional inspection of the vessel bottom, a helium leak test, and dye penetrant inspection of the welds. The vermiculite material used in the cask rack assembly was replaced.

  18. Spanish validation of the PAS-ADD Checklist Questionnaire for people with intellectual disabilities for Spanish population.

    Science.gov (United States)

    Martorell, A; González, M C; Gutiérrez, P; Rincón, F; Núñez-Polo, M H

    2017-10-01

    The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) is an international reference tool for the diagnosis and assessment of mental health problems and behavioural disorders among people with intellectual disabilities. Although the original PAS-ADD instrument has been validated in the Spanish language, the shorter PAS-ADD Checklist has yet not been validated. The aim of this study is to validate the PAS-ADD Checklist for the Spanish population. The PAS-ADD Checklist Questionnaire was administered to 208 adults with intellectual disabilities at a vocational centre in Madrid, Spain. The psychometric analyses included internal consistency, inter-rater and test-retest reliability, Varimax rotation factor analysis for construct validity, criterion validity and feasibility. The Cronbach's alpha was 0.80 for the overall questionnaire and between 0.40 and 0.79 for the subscales. The Kappa coefficients for test-retest and inter-rater reliability were between 0.66 and 0.80. Varimax rotation factor analysis showed five well-defined factors. The Kappa coefficients for criterion validity were between 0.30 and 0.70. Feasibility was also good. The PAS-ADD Checklist is a feasible and reliable instrument for carrying out initial assessment of the mental health status of adults with intellectual disabilities, referring cases to more specialised diagnosis and treatment. © 2017 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

  19. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Marreilha dos Santos, A.P., E-mail: apsantos@ff.ul.pt [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal); Lucas, Rui L.; Andrade, Vanda; Mateus, M. Luísa [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal); Milatovic, Dejan; Aschner, Michael [Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 (United States); Batoreu, M. Camila [I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon (Portugal)

    2012-02-01

    Chronic, excessive exposure to manganese (Mn) may induce neurotoxicity and cause an irreversible brain disease, referred to as manganism. Efficacious therapies for the treatment of Mn are lacking, mandating the development of new interventions. The purpose of the present study was to investigate the efficacy of ebselen (Ebs) and para-aminosalicylic acid (PAS) in attenuating the neurotoxic effects of Mn in an in vivo rat model. Exposure biomarkers, inflammatory and oxidative stress biomarkers, as well as behavioral parameters were evaluated. Co-treatment with Mn plus Ebs or Mn plus PAS caused a significant decrease in blood and brain Mn concentrations (compared to rats treated with Mn alone), concomitant with reduced brain E{sub 2} prostaglandin (PGE{sub 2}) and enhanced brain glutathione (GSH) levels, decreased serum prolactin (PRL) levels, and increased ambulation and rearing activities. Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity. -- Highlights: ► The manuscript is unique in its approach to the neurotoxicity of Mn. ► The manuscript incorporates molecular, cellular and functional (behavioral) analyses. ► Both PAS and Ebs are effective in restoring Mn behavioral function. ► Both PAS and Ebs are effective in reducing Mn-induced oxidative stress. ► Both PAS and Ebs led to a decrease in Mn-induced neuro-inflammation.

  20. [Gardner syndrome--parent alienation syndrome (PAS). Diagnosis or family reality?].

    Science.gov (United States)

    Namysłowska, Irena; Heitzman, Janusz; Siewierska, Anna

    2009-01-01

    The authors present characteristics of Parental Alienation Syndrome (PAS) proposed by Gardner as well as data, which may help to differentiate that syndrome with real psychological, physical and sexual abuse. The consequences of Gardner Syndrome for legal decisions in the court cases of child custody and the critique of this syndrome in forensic and psychiatric literature are also discussed, and several questions posed. Authors propose to treat Gardner Syndrome not as as a child disorder but as a specific, dynamic family situation, which occurs sometimes, during divorce and fight about child custody.

  1. 76 FR 1663 - Announcement of a Meeting of the International Telecommunication Advisory Committee

    Science.gov (United States)

    2011-01-11

    ... Announcement of a Meeting of the International Telecommunication Advisory Committee SUMMARY: This notice announces a meeting of the International Telecommunication Advisory Committee (ITAC) to prepare for the International Telecommunication Union (ITU) World Conference on International Telecommunications, as well as for...

  2. 75 FR 10860 - Announcement of a Meeting of the International Telecommunication Advisory Committee

    Science.gov (United States)

    2010-03-09

    ... Announcement of a Meeting of the International Telecommunication Advisory Committee SUMMARY: This notice announces a meeting of the International Telecommunication Advisory Committee (ITAC) to prepare for an April 19- 30 meeting of International Telecommunication Union (ITU) Telecommunication Standardization...

  3. 76 FR 18292 - Announcement of a Meeting of the International Telecommunication Advisory Committee

    Science.gov (United States)

    2011-04-01

    ... Announcement of a Meeting of the International Telecommunication Advisory Committee SUMMARY: This notice announces a meeting of the International Telecommunication Advisory Committee (ITAC) to prepare for the International Telecommunication Union (ITU) World Radiocommunication Conference and the Radiocommunication...

  4. 75 FR 35122 - Announcement of Meetings of the International Telecommunication Advisory Committee

    Science.gov (United States)

    2010-06-21

    ... Announcement of Meetings of the International Telecommunication Advisory Committee Summary: This notice announces meetings of the International Telecommunication Advisory Committee (ITAC) to start preparations for the 2010 Plenipotentiary Conference of the International Telecommunication Union (ITU) and the...

  5. 76 FR 48939 - Announcement of Meeting of the International Telecommunication Advisory Committee

    Science.gov (United States)

    2011-08-09

    ... Announcement of Meeting of the International Telecommunication Advisory Committee SUMMARY: This notice announces a meeting of the International Telecommunication Advisory Subcommittees (ITAC) on August 22, 2011... advice from the telecommunications industry on: (a) The consultation of International Telecommunication...

  6. Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are located predominantly in the PAS domains.

    Science.gov (United States)

    Greb-Markiewicz, Beata; Orłowski, Marek; Dobrucki, Jerzy; Ożyhar, Andrzej

    2011-10-15

    Methoprene-tolerant protein (MET) is a key mediator of antimetamorphic signaling in insects. MET belongs to the family of bHLH-PAS transcription factors which regulate gene expression and determine essential physiological and developmental processes. The ability of many bHLH-PAS proteins to carry out their functions is related to the patterns of intracellular trafficking, which are determined by specific sequences and indicate that a nuclear localization signal (NLS) or a nuclear export signal (NES) is present and active. Therefore, the identification of NLS and NES signals is fundamental in order to understand the intracellular signaling role of MET. Nevertheless, data on the intracellular trafficking of MET are inconsistent, and until now there hasn't been any data on potential NLS and NES sequences. To analyze the trafficking of MET we designed a number of expression vectors encoding full-length MET, as well as various derivatives, that were fused to yellow fluorescent protein (YFP). Confocal microscopy analysis of the subcellular distribution of YFP-MET indicated that while this protein was localized mainly in the nucleus, it was also observed in the cytoplasm. This suggested the presence of both an NLS and NES in MET. Our work has shown that each of the two PAS domains of MET (PAS-A and PAS-B, respectively) contain one NLS and one NES sequence. Additional NES activity was present in the C-terminal fragment. The NLS activity located in PAS-B was dependent on the presence of juvenile hormone (JH), the potential ligand for MET. In contrast to this, JH didn't seem to be required for the NLS in PAS-A to be active. However, on the basis of current knowledge about the function of PAS-A in other bHLH-PAS proteins, we suggest there might be other proteins that control the activity of the NLS and possibly the NES located in the PAS-A of MET. Thus, the intracellular trafficking of MET seems to be regulated by a rather complicated network of different factors. Copyright

  7. Piraterie maritime: pas d’«internationalisation» de la fonction juridictionnelle

    Directory of Open Access Journals (Sweden)

    Jean-Marc Thouvenin

    2013-01-01

    Full Text Available La crise de la piraterie maritime qui a longuement sévi au large de la Somalie est en voie de résorption, mais les pirates n’ont pas cessé leurs ataques qui se produisent désormais dans les eaux de l’Afrique de l’ouest. Pour y faire face, et traduire les pirates en justice, la Communauté internationale s’est rapidement appuyée sur les tribunaux des États de la région, tout en exigeant d’eux le respect des standards du procès équitable ainsi que des droits de l’homme. Elle s’est engagée dans un fort soutien, à la fois technique, financier et juridique, à leur action. Les résultats n’ayant pas été immédiats, l’idée de créer une juridiction internationale, ou internationalisée, a été évoquée par le Conseil de sécurité des Nations Unies. Elle a finalement été rejetée, au profit d’un renforcement de l’action en faveur des processus judiciaires nationaux de lutte contre la piraterie.

  8. JPCam: Development of a 1.2 Gpixel Camera for the J-PAS Survey

    Science.gov (United States)

    Marín-Franch, A.; Taylor, K.; Santoro, F. G.; Laporte, R.; Cepa, J.; Lasso-Cabrera, N.; Yanes-Díaz, A.; Cenarro, A. J.; Cristobal-Hornillos, D.; Ederoclite, A.; Moles, M.; Varela, J.; Vázquez-Ramió, H.; Antón, J. L.; Bello, R.; Civera, T.; Castillo, J.,; Chueca, S.; Guillén-Civera, L.; Hernández-Fuertes, J.; Igual, R.; Íniguez, C.; López-Alegre, G.; López-Sainz, A.; Nevot, C.; Milla, R.; Muniesa, D.; Pe, A.; Rueda-Teruel, R.; Rueda-Teruel, F.; Sánchez, J.; Benitez, N.; Dupke, R.; Fernández-Soto, A.; Mendes de Oliveira, C.; Sodré, L.

    2017-03-01

    To carry out J-PAS survey, the JST/T250 telescope at the Observatorio Astrofósico de Javalambre (OAJ) is equipped with JPCam, a panoramic camera designed to exploit survey capabilities of the telescope. JPCam is a direct imaging instrument designed to work in a fast convergent beam at the telescope’s Cassegrain focus. It is based on state-of-the-art, high efficiency, low noise 9.2k-by-9.2k, 10μm pixel CCDs specially developed by e2v for JPCam. The instrument is equipped with a 1.2Gpixel mosaic of 14 CCDs providing a useful FoV of 4.7 deg2 (67% focal plane coverage) with a plate scale of 0.2267 arcsec/pix. Moreover, JPCam includes 12 auxiliary detectors for auto-guiding and wave front sensing purposes. JPCam is completed with an innovative set of 59 optical filters specifically designed to perform accurate BAO measurements, main science driver of J-PAS.

  9. Meeting with Jean-Yves Le Meur, author of "Faux Pas"

    CERN Multimedia

    2008-01-01

    A CERN engineer and an accomplished sportsman, Jean-Yves Le Meur (IT Department) has recently published his first book "Faux pas". Meet him and hear about his exceptional life on 23 April 2008 in the Globe. An accident cost him his legs when he was young, and it was sheer force of character and a passion for the mountains that carried Jean-Yves Le Meur, with one artificial leg and crutches to stay upright, to the very summit of the Mont-Blanc. In his book, Jean-Yves, a computer engineer at CERN, recounts with detachment his personal battle to win back his life and make this impossible ascent. "Faux Pas" depicts a series of encounters and people, and recreates the extreme emotions of a man who reconstructed his life and pushed himself beyond his limits. It is a moving personal account, whose message is universal. The question-and-answer session with the author will be preceded by the projection of "4810M, CAHIN-CAHA",...

  10. Application of FTIR-PAS and Raman spectroscopies for the determination of organic matter in farmland soils.

    Science.gov (United States)

    Xing, Zhe; Du, Changwen; Tian, Kang; Ma, Fei; Shen, Yazhen; Zhou, Jianmin

    2016-09-01

    In soil analysis, Raman spectroscopy is not as widely used as infrared spectroscopy mainly owing to fluorescence interferences. This paper investigated the feasibility of Fourier-transform infrared photoacoustic (FTIR-PAS) and Raman spectroscopies for predicting soil organic matter (SOM) using partial least squares regression (PLSR) analysis. 194 farmland soil samples were collected and scanned with FTIR and Raman spectrometers in the spectral range of 4000-400cm(-1) and 180-3200cm(-1), respectively. For the PLSR models, the combined dataset was split into 146 samples as the calibration set (75%) and 48 samples as the validation set (25%). The optimal number of analytical factors was determined using a leave-one-out cross-validation. The results showed that SOM could be predicted using FTIR-PAS and Raman spectroscopies independently, with R(2)>0.70 and RPD>1.8 for the validation sets. In comparison to the single applications of FTIR-PAS and Raman spectroscopies, accurate prediction of SOM was made by combining FTIR-PAS and Raman spectroscopies, with R(2)=0.81 and RPD=2.18 for the validation sets. By statistically assessing large amounts of PLS models, model-population analysis confirmed that the accuracy of the PLS model can be increased by combining FTIR-PAS and Raman spectroscopies. In conclusion, the combination of FTIR-PAS and Raman spectroscopies is a promising alternative for soil characterization, especially for the prediction of SOM, owing to the availability of complementary information from both FTIR-PAS (polar vibrations) and Raman spectroscopy (non-polar vibrations). Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy.

    Science.gov (United States)

    Pascarella, Angelo; Terracciano, Chiara; Farina, Olimpia; Lombardi, Luca; Esposito, Teresa; Napolitano, Filomena; Franzese, Giuseppina; Panella, Giovanni; Tuccillo, Francesco; la Marca, Giancarlo; Bernardini, Sergio; Boffo, Silvia; Giordano, Antonio; Melone, Mariarosa Anna Beatrice; Di Iorio, Giuseppe; Sampaolo, Simone

    2017-12-07

    Autosomal recessive Pompe disease is a lysosomal disorder caused by mutations of the acid-α-glucosidase (GAA) gene. Deficiency of GAA enzyme leads to glycogen accumulation and autophagy impairment in cardiac and skeletal muscles, but also in lymphocytes. Since an effective therapy is available, a rapid, sensitive and specific test is crucial to early identify affected subjects. Number of lymphocytes containing PAS-positive vacuoles was evaluated on blood films from 72 consecutive adult patients with hyperckemia and/or muscle weakness, 13 genetically confirmed late-onset-Pompe-disease (LOPD) and 13 of their offspring. GAA activity, measured on dried blood spot (DBS) in all patients inversely correlated with number of PAS-positive lymphocytes. More than 4 PAS-positive lymphocytes were found in 11 out of the 72 patients (6 new diagnosis of LOPD, 3 different glycogen storage myopathies, 1 glucose-6-phosphate dehydrogenase deficiency, 1 caveolinopathy), in all 13 LOPD patients and in the 13 LOPD offspring. These latter resulted to have all a single GAA mutation but low GAA levels. Immunostaining with the autophagy markers LC3 and p62 confirmed the autophagic nature of lymphocytes vacuoles. ROC curve assessment of PAS-positive lymphocytes disclosed 100% of sensitivity and 94% of specificity in recognizing both compound heterozygous and heterozygous GAA carriers. The other myopathies with more than 4 PAS-positive lymphocytes appeared to be all related to impaired autophagy, which seems to be responsible of PAS-positive vacuolated lymphocytes formation. Quantification of PAS-positive lymphocytes in blood films is useful to identify autophagic vacuolar myopathies and should be routinely used as first level test for Pompe disease. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Dante n’est pas uniquement sévère (Dante no es únicamente severo ou comment ne pas raconter une histoire

    Directory of Open Access Journals (Sweden)

    Jean-Paul Aubert

    2011-01-01

    Full Text Available Dante no es únicamente severo [Dante n’est pas uniquement sévère], un film de Joaquín Jordà et Jacinto Esteva, s’est voulu une vitrine de l’Ecole de Barcelone. Ce courant cinématographique actif à partir de 1965 et jusqu’au début des années soixante-dix, s’est notamment distingué par son refus de l’orthodoxie du récit. A ce titre, il a pu apparaître comme un avatar des cinémas de la modernité. Mais, l’Ecole de Barcelone et ce film qui en synthétise les principes doivent être envisagés dans le contexte particulier de l’Espagne sous le franquisme. La contestation du récit y acquiert une dimension politique et éthique.Dante no es únicamente severo, una película de Joaquín Jordà y Jacinto Esteva, pretende hacer la síntesis del proyecto estético de la Escuela de Barcelona (una corriente cinematográfica activa desde del año 1965 y hasta principios de la década de los setenta. Por su rechazo de la ortodoxia del relato la Escuela de Barcelona se sitúa en la continuidad de los cines de la modernidad. Sin embargo, conviene examinar esta corriente y este film, en particular, en el contexto particular de la España franquista, donde el rechazo del relato abarca dimensiones política y éticas.

  13. Global capacity announcement of electrical distribution systems: A pragmatic approach

    OpenAIRE

    Cornélusse, Bertrand; Vangulick, David; Glavic, Mevludin; Ernst, Damien

    2015-01-01

    We propose a pragmatic procedure to facilitate the connection process of Distributed Generation (DG) with reference to the European regulatory framework where Distribution System Operators (DSOs) are, except in specific cases, not allowed to own their generation. The procedure is termed Global Capacity ANnouncement (GCAN) and is intended to compute the estimates of maximum generation connection amount at appropriate substations in a distribution system, to help generation connection decisions...

  14. An Interrater Reliability Study of Rorschach Performance Assessment System (R-PAS) Raw and Complexity-Adjusted Scores.

    Science.gov (United States)

    Pignolo, Claudia; Giromini, Luciano; Ando', Agata; Ghirardello, Davide; Di Girolamo, Marzia; Ales, Francesca; Zennaro, Alessandro

    2017-01-01

    Recently, the Rorschach Performance Assessment System (R-PAS; Meyer, Viglione, Mihura, Erard, & Erdberg, 2011 ) was introduced to overcome some possible limitations of the Comprehensive System (CS; Exner, 2003 ) while continuing its efforts to link Rorschach inferences to their evidence base. An important, technical modification to the scoring system is that R-PAS interpretations are based on both standard scores and complexity-adjusted scores. Two previous U.S. studies reported good to excellent interrater reliability (IRR) for the great majority of R-PAS variables; however, IRR of complexity-adjusted scores has never been investigated. Furthermore, no studies have yet investigated R-PAS IRR in Europe. To extend this literature, we examined R-PAS IRR of Page 1 and Page 2 raw and complexity-adjusted scores with 112 Italian Rorschach protocols. We collected a large sample of both clinical and nonclinical Rorschach protocols, each of which was coded separately by 2 independent raters. Results demonstrated a mean intraclass correlation of .78 (SD = .14) for raw scores and.74 (SD = .14) for complexity-adjusted scores. Overall, for both raw and complexity-adjusted values, most of the variables were characterized by good to excellent IRR.

  15. The polypeptide biophysics of proline/alanine-rich sequences (PAS): Recombinant biopolymers with PEG-like properties.

    Science.gov (United States)

    Breibeck, Joscha; Skerra, Arne

    2017-10-27

    PAS polypeptides comprise long repetitive sequences of the small L-amino acids proline, alanine and/or serine that were developed to expand the hydrodynamic volume of conjugated pharmaceuticals and prolong their plasma half-life by retarding kidney filtration. Here, we have characterized the polymer properties both of the free polypeptides and in fusion with the biopharmaceutical IL-1Ra. Data from size exclusion chromatography, dynamic light scattering, circular dichroism spectroscopy and quantification of hydrodynamic and polar properties demonstrate that the biosynthetic PAS polypeptides exhibit random coil behavior in aqueous solution astonishingly similar to the chemical polymer poly-ethylene glycol (PEG). The solvent-exposed PAS peptide groups, in the absence of secondary structure, account for strong hydrophilicity, with negligible contribution by the Ser side chains. Notably, PAS polypeptides exceed PEG of comparable molecular mass in hydrophilicity and hydrodynamic volume while exhibiting lower viscosity. Their uniform monodisperse composition as genetically encoded polymers and their biological nature, offering biodegradability, render PAS polypeptides a promising PEG mimetic for biopharmaceutical applications. © 2017 The Authors Biopolymers Published by Wiley Periodicals, Inc.

  16. « Y être ou pas ? » Le mystère Dylan

    Directory of Open Access Journals (Sweden)

    Christophe Lebold

    2009-09-01

    Full Text Available Fidèle à ses rendez-vous annuels que ses aficionados appellent depuis vingt ans "la tournée sans fin", Bob Dylan est revenu en France. Au mois de juin 2008, tout juste de retour d’une tournée en Amérique du Sud et d’un passage éclair en Nouvelle Angleterre, récemment couronné d’un prix Pulitzer, il a donné deux nouveaux concerts, l’un à Toulouse, l’autre à Grenoble. Pour une fois, je n’y étais pas, occupé à suivre en Europe une autre icône de la chanson, Leonard Cohen. Mais je sais cependant ...

  17. [Evaluation of the website of the Nord-Pas-de-Calais regional pharmacovigilance center].

    Science.gov (United States)

    Rochoy, Michaël; Béné, Johana; Messaadi, Nassir; Auffret, Marine; Gautier, Sophie

    2016-06-01

    We posted the Nord-Pas-de-Calais regional pharmacovigilance center website and distributed a survey to its potential users between August 2014 and October 2014 (135 general practitioners, 45 pharmacists, 14 patients). Satisfaction was 7.3±1.6 out of 10 points for the visual aspect, 7.8±1.5 out of 10 points for navigation and 7.6±1.4 out of 10 points for content. The website was declared useful by 98% respondents, particularly for the reporting of adverse drugs reactions (89%). Copyright © 2016 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

  18. Facteur 4 en Nord-Pas de Calais : impacts socio-économiques

    Directory of Open Access Journals (Sweden)

    Nicolas Houdant

    2011-03-01

    Full Text Available L’objectif de division par quatre des émissions de gaz à effet de serre à l’horizon 2050 aura des conséquences majeures sur les territoires, les ménages, les entreprises. Si l’objectif est global, les conséquences des changements drastiques nécessaires pour y parvenir seront localisées. Nous avons étudié les conséquences de la réduction forte des émissions de gaz à effet de serre dans la région Nord Pas de Calais à l’horizon 2020-2050, notamment pour la réhabilitation du logement et le transport des personnes. Une quantification des conséquences budgétaires de ces politiques incontournables montre que la contrainte devient forte voire insoutenable pour la majorité des ménages. Ces résultats conduisent à dresser une déclinaison des enjeux et des politiques sur le territoire régional.Cutting the greenhouse gas emissions by four by 2050 will have major consequences on local economies, households and policies. This objective is global, however, consequences will have to be faced and dealt with locally. We have studied the consequences of deep reductions of greenhouse gas emissions in the Nord Pas-de-Calais region by 2020-2050, in particular regarding housing renovation and mobility. Modelling the financial consequences of these necessary policies show that constraints become strong and even unbearable for a majority of household. These results call for well-informed and locally-based policies.

  19. Linking mineral deposits to speleogenetic processes in Cova des Pas de Vallgornera (Mallorca, Spain

    Directory of Open Access Journals (Sweden)

    Bogdan P. Onac

    2014-05-01

    Full Text Available Cova des Pas de Vallgornera (CPV is the premier cave of the Balearic Archipelago. Over 74 km of passages develop within two carbonate lithofacies (reef front and back reef, which ultimately control the patterns of the cave and to some degree its mineral infilling. The diversity of speleothem-forming minerals is four times greater around or within hypogene-related features (vents, rims, cupolas, compared to any other vadose passages in the cave. The mineralogy of speleothems (crusts, nodules, crystals, earthy masses associated with hypogene features in the seaward upper maze of Sector F is characterized by the presence of aragonite, ankerite, huntite, clay minerals, and quartz. In the Tragus and Nord sectors, however, the dominant mineral is dolomite, along with aragonite, celestine, huntite, clay minerals, and quartz. Calcite is by far the most ubiquitous mineral throughout the cave. Detailed macroscopic and scanning electron microanalysis and imaging have permitted the investigation of textural relationships between the minerals associated with vents, rims, and vent’s roof and walls. These studies along with morphological and stable isotope analyses confirm that not all minerals are connected with a hypogene stage in the cave evolution, and furthermore, none of them appears to be sulfuric acid by-products. Instead, the mineral assemblages documented in speleothems from CPV clearly support at least three speleogenetic pathways, namely seacoast mixing, ascending of warm groundwaters, and meteoric recharge (vadose. Thus, cave minerals in Cova des Pas de Vallgornera hold the keys to reconstruction and understanding of processes and conditions under which they precipitated, allowing to establish their relationship with various speleogenetic pathways.

  20. J-PAS and J-PLUS: large sky multi-filter surveys from the Observatorio Astrofisico de Javalambre

    Science.gov (United States)

    Cenarro, A. J.; J-PAS Collaboration; J-PLUS Collaboration

    2017-03-01

    During the first years of operation, the Observatorio Astrofísico de Javalambre, in Teruel, is mostly devoted to conduct two large sky multi-filter surveys making use of two telescopes of large field of view, JST/T250 and JAST/T80, and their respective panoramic instrumentation, JPCam and T80Cam. These surveys, managed and developed within a long-term Spanish-Brazilian collaboration of astronomers who cover most fields in Astronomy and Cosmology, are the Javalambre Physics of the Accelerating Universe Astrophysical Survey (J-PAS) and the Javalambre Photometric Local Universe Survey (J-PLUS). J-PAS will observe 8500 deg^2 of the sky visible from Javalambre with a set of 54 narrow-band contiguous optical filters plus 5 broader ones, performing in the end as a low resolution integral field unit for the Northern hemisphere. It will provide unprecedented spectral energy distributions for every pixel of the sky, and ultimately for more than 200 million galaxies and stars. In advance, J-PLUS has started to observe the same sky area of J-PAS with 12 narrow, intermediate and broad-band filters aimed to provide the photometric calibration of J-PAS, and unprecedented multicolor data for many fields of the Astrophysics. Both J-PAS and J-PLUS will provide powerful 3D views of the Universe that will be made publicly available to the community as legacy projects. This proceeding is aimed to present the origin, motivation, characteristics and main scientific goals of the J-PAS and J-PLUS projects as well as the Spanish-Brazilian collaboration making them happen.

  1. Utility of PAS and β-catenin staining in histological categorisation and prediction of prognosis of hepatoblastomas.

    Science.gov (United States)

    Bera, Goutam; Das, Ram Narayan; Roy, Paromita; Ghosh, Ranajoy; Islam, Nelofar; Mishra, Prafulla Kumar; Chatterjee, Uttara

    2017-06-19

    The aim of this study was to assess the usefulness of PAS, β-catenin and Ki-67 in categorising hepatoblastomas (HBs) and their significance in predicting prognosis. In addition, we have also documented the various chemotherapy induced histologic changes in HBs. In this retrospective observational study of 29 cases of hepatoblastomas, 27 cases were considered for statistical analysis, excluding two cases of diagnostic core biopsies. All clinicopathological parameters and follow up data were collected. All HB cases including the mixed epithelial and mesenchymal HBs were classified into two groups: fetal predominant and embryonal predominant type according to the predominant epithelial component. PAS, β-catenin and Ki-67 staining were done and their correlation with histologic subtypes was assessed. Kaplan-Meier survival analysis was performed in relation to histology, PAS, β-catenin and Ki-67 staining characteristics. Diffuse nuclear staining of β-catenin was significantly more common in embryonal predominant type (p = 0.036), whereas strong PAS positivity was significantly associated with fetal predominant type (p = 0.002). But no significant correlation was seen between histologic type and Ki-67 staining (p = 0.42). Survival analysis showed cases with diffuse PAS positivity, focal nuclear β-catenin staining and low Ki-67 LI had better survival. PAS is a simple stain and can be utilised in histological categorisation of HB and also predicting its outcome. Nuclear β-catenin staining which is significantly common in embryonal elements in HB predicts shorter survival.

  2. Protein Alpha Shape (PAS) Dock: a new gaussian-based score function suitable for docking in homology modelled protein structures.

    Science.gov (United States)

    Tøndel, Kristin; Anderssen, Endre; Drabløs, Finn

    2006-03-01

    Protein Alpha Shape (PAS) Dock is a new empirical score function suitable for virtual library screening using homology modelled protein structures. Here, the score function is used in combination with the geometry search method Tabu search. A description of the protein binding site is generated using gaussian property fields like in Protein Alpha Shape Similarity Analysis (PASSA). Gaussian property fields are also used to describe the ligand properties. The overlap between the receptor and ligand hydrophilicity and lipophilicity fields is maximised, while minimising steric clashes. Gaussian functions introduce a smoothing of the property fields. This makes the score function robust against small structural variations, and therefore suitable for use with homology models. This also makes it less critical to include protein flexibility in the docking calculations. We use a fast and simplified version of the score function in the geometry search, while a more detailed version is used for the final prediction of the binding free energies. This use of a two-level scoring makes PAS-Dock computationally efficient, and well suited for virtual screening. The PAS-Dock score function is trained on 218 X-ray structures of protein- ligand complexes with experimental binding affinities. The performance of PAS-Dock is compared to two other docking methods, AutoDock and MOE-Dock, with respect to both accuracy and computational efficiency. According to this study, PAS-Dock is more computationally efficient than both AutoDock and MOE-Dock, and gives a better prediction of the free energies of binding. PAS-Dock is also more robust against structural variations than AutoDock.

  3. Television and Nostalgia. The Wonder Years and Cuéntame cómo pasó/ Televisión y nostalgia. The Wonder Years y Cuéntame cómo pasó

    Directory of Open Access Journals (Sweden)

    Dra. Amparo Guerra Gómez; aguerrag@ccinf.ucm.es, amparoguerragomez@yahoo.es

    2009-01-01

    Full Text Available From the start historical fiction had been functioning as a worldwide resource for television programming and contents. Concerning to dynamics and diachronic ways of development a couple of trends can be observed in re-constructions of the past of this sort. On a hand, visual resources tend to be represented by characters and scenes in the form of a diverse but affluent model that prevails in universal television products. On the other, formats show a clear confluence in terms of specific social and cultural treatment, local or national. This paper explores two representative examples of historical family television series: the American The Wonder Years (1988-1993, and the more recent Spanish one Cuéntame como pasó (2001…-. In the pages that follow contents and profiles of each fiction will be analyzed from a theoretical point of view and a methodology that remarks proper issues and topics in order to establish historical events in which narrative is supported. Both sharing nostalgia and empathy as key forms of identification in television evocative stories and ways of approaching to different audiences, each one refered to distant geographical and social contexts. La ficción histórica constituye un recurso característico en la programación televisiva internacional. En su desarrollo diacrónico pueden resaltarse dos dinámicas confluyentes: la derivada de la internacionalización de propuestas y formatos, y la referida a su adecuación a coordenadas socioculturales, mucho más específicas, de carácter nacional o local.Estos programas se han ambientado en escenarios históricos diversos. En lo que respecta a su emplazamiento en períodos relativamente próximos, con frecuencia han apelado a claves de reconocimiento nostálgico, implicadas con la memoria personal de un grueso de espectadores.Este trabajo se aproxima a dos ejemplos bien definidos de ficción histórica televisiva: la serie estadounidense The Wonder Years (1988-1993, y la

  4. 75 FR 7370 - Closed Captioning of Video Programming; Closed Captioning Requirements for Digital Television...

    Science.gov (United States)

    2010-02-19

    ... Television Receivers AGENCY: Federal Communications Commission. ACTION: Final rule; announcement of effective... Closed Captioning of Video Programming; Closed Captioning Requirements for Digital Television Receivers...

  5. 78 FR 71619 - Medicare and Medicaid Programs; Continued Approval of American Osteopathic Association/Healthcare...

    Science.gov (United States)

    2013-11-29

    ... Approval of American Osteopathic Association/Healthcare Facilities Accreditation Program's Critical Access.... SUMMARY: This final notice announces our decision to approve the American Osteopathic Association...

  6. Immunosuppressive PAS-1 is an excretory/secretory protein released by larval and adult worms of the ascarid nematode Ascaris suum.

    Science.gov (United States)

    Antunes, M F P; Titz, T O; Batista, I F C; Marques-Porto, R; Oliveira, C F; Alves de Araujo, C A; Macedo-Soares, M F

    2015-05-01

    Helminths use several strategies to evade and/or modify the host immune response, including suppression or inactivation of the host antigen-specific response. Several helminth immunomodulatory molecules have been identified. Our studies have focused on immunosuppression induced by the roundworm Ascaris suum and an A. suum-derived protein named protein 1 from A. suum (PAS-1). Here we assessed whether PAS-1 is an excretory/secretory (E/S) protein and whether it can suppress lipopolysaccharide-induced inflammation. Larvae from infective eggs were cultured in unsupplemented Dulbecco's modified Eagle medium (DMEM) for 2 weeks. PAS-1 was then measured in the culture supernatants and in adult A. suum body fluid at different time points by enzyme-linked immunosorbent assay (ELISA) with the monoclonal antibody MAIP-1. Secreted PAS-1 was detected in both larval culture supernatant and adult body fluid. It suppressed lipopolysaccharide (LPS)-induced leucocyte migration and pro-inflammatory cytokine production, and stimulated interleukin (IL)-10 secretion, indicating that larval and adult secreted PAS-1 suppresses inflammation in this model. Moreover, the anti-inflammatory activity of PAS-1 was abolished by treatment with MAIP-1, a PAS-1-specific monoclonal antibody, confirming the crucial role of PAS-1 in suppressing LPS-induced inflammation. These findings demonstrate that PAS-1 is an E/S protein with anti-inflammatory properties likely to be attributable to IL-10 production.

  7. Austria announces new money for research infrastructure and social sciences

    CERN Multimedia

    2008-01-01

    Austria's Minister for Science and Research, Johannes Hahn, has announced funding for research infrastructures and the social sciences, amounting to EUR 6.9 million in total. The largest chunk of the money will go to a new data processing centre for the analysis of data from the European Organisation for Nuclear Research (CERN). The idea is that the new centre will provide Austria with access to the key technology for solving highly complex scientific and technological problems, while strengthening Austria's domestic research infrastructure in the field of 'advanced communication networks'.

  8. The Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD) Checklist: Reliability and Validity of French Version

    Science.gov (United States)

    Gerber, F.; Carminati, G. Galli

    2013-01-01

    Background: The lack of psychometric measures of psychopathology especially in intellectual disabilities (ID) population was addressed by creation of the Psychiatric Assessment Schedule for Adult with Developmental Disability (PAS-ADD-10) in Moss et?al. This schedule is a structured interview designed for professionals in psychopathology. The…

  9. Morphological Evaluation of Proximal Anastomosis by PAS-Port(®) System in Patients with Long-Term Patent Grafts.

    Science.gov (United States)

    Kawasaki, Muneyasu; Fujii, Takeshiro; Hara, Masanori; Sasaki, Yuki; Katayanagi, Tomoyuki; Okuma, Shinnosuke; Watanabe, Yoshinori

    2015-01-01

    We examined grafts employing for morphological analysis of early and long-term results on proximal anastomosis with the PAS-Port(®). One hundred and four patients treated by OPCAB with PAS-Port(®) were performed postoperative MDCT. Morphological evaluation of the proximal anastomotic region was classified into three groups (A; graft was anastomosed almost perpendicularly to the aortic wall, B; graft was same type A, but subsequently curved to form an acute angle with the aortic wall, C; graft take off acute angle with the aortic wall) evaluated on planar and sagittal sections. One hundred twenty-six PAS-Port(®) were used. Patency rate was 99.0% at discharge, 94.7% at 1 year, and no blockages were detected thereafter in patients examined. The morphology rate was A 50.6%, B 15.3% and C 34.1% on planar sections, and A 58.8%, B 10.6% and C 30.6% on sagittal sections. The morphological evaluation of grafts revealed the degree of freedom in graft design to be relatively high and long-term patency posed no particular problem even if the layout of the proximal anastomotic region involved a relatively acute angle. The PAS-Port(®) was considered to be a highly reliable device which performed appropriate proximal anastomosis and improved the patency of vein grafting to the aortic wall.

  10. 47 CFR Appendix B to Part 64 - Priority Access Service (PAS) for National Security and Emergency Preparedness (NSEP)

    Science.gov (United States)

    2010-10-01

    .... 64, App. B Appendix B to Part 64—Priority Access Service (PAS) for National Security and Emergency...; (d) National Coordinating Center; (e) National Security Emergency Preparedness (NSEP... and control functions critical to management of and response to national security and emergency...

  11. Rorschach Performance Assessment System (R-PAS) and vulnerability to stress: A preliminary study on electrodermal activity during stress.

    Science.gov (United States)

    Giromini, Luciano; Ando', Agata; Morese, Rosalba; Salatino, Adriana; Di Girolamo, Marzia; Viglione, Donald J; Zennaro, Alessandro

    2016-12-30

    This study investigated the predictive validity of the ten Rorschach Performance Assessment System (R-PAS) variables from the Stress and Distress domain, by testing whether they predicted increased sympathetic reactivity to a mild, laboratory-induced stress, occurred one week after Rorschach administration. A relatively small student sample (N=52) contributed to this research: During a first meeting (T1) participants were administered the Rorschach task according to R-PAS guidelines; about one week later (T2) their electrodermal activity (EDA) was recorded during exposure to a mild laboratory stress-inducing task. Based on literature indicating that exposure to stress tends to increase physiological vulnerability/reactivity to stressful situations, we anticipated that Stress and Distress R-PAS variables measured at T1 would positively correlate with increased sympathetic reactivity to stress at T2, as indicated by greater EDA changes from baseline to stress and recovery. Results partially confirmed our hypotheses: (a) the mean of and (b) the majority of the Stress and Distress R-PAS variables were significantly correlated, in the expected direction, with medium and medium to large effect sizes. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  12. HIF has Biff - Crosstalk between HIF1a and the family of bHLH/PAS proteins.

    Science.gov (United States)

    Button, Emily L; Bersten, David C; Whitelaw, Murray L

    2017-07-15

    Two decades of research into functions of the ubiquitous transcription factor HIF have revealed pervasive roles in development, oxygen homeostasis, metabolism, cancer and responses to ischemia. Unsurprisingly, HIF activities impinge on many pathologies, for which underlying molecular mechanisms are actively sought. HIF is a member of the heterodimeric bHLH/PAS family of transcription factors, a set of proteins that commonly function in developmental pathways and adaptive responses to environmental or physiological stress. Similarities in the mechanisms that regulate gene targeting by these transcription factors create opportunities for extensive crosstalk between family members. Data supporting pathway interactions between HIF1a and other bHLH/PAS factors, both collaborative and antagonistic, is beginning to surface in the areas of cancer, circadian rhythm, and immune responses. This review summarises the status of HIF1a-bHLH/PAS protein crosstalk and is dedicated to the memory of Lorenz Poellinger, a pioneer investigator into the molecular mechanisms of HIF, AHR, and ARNT bHLH/PAS factors. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  13. Biological control of Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) using Aeromonas phage PAS-1.

    Science.gov (United States)

    Kim, J H; Choresca, C H; Shin, S P; Han, J E; Jun, J W; Park, S C

    2015-02-01

    The potential control efficacy of Aeromonas phage PAS-1 was evaluated against Aeromonas salmonicida subsp. salmonicida infection in rainbow trout (Oncorhynchus mykiss) model in this study. The phage was co-cultured with the virulent A. salmonicida subsp. salmonicida strain AS05 that possesses the type III secretion system (TTSS) ascV gene, and efficient bacteriolytic activity was observed against the bacteria. The administration of PAS-1 in rainbow trout demonstrated that the phage was cleared from the fish within 200 h post-administration, and a temporal neutralizing activity against the phage was detected in the sera of phage-administrated fish. The administration of PAS-1 (multiplicity of infection: 10 000) in A. salmonicida subsp. salmonicida infected rainbow trout model showed notable protective effects, with increased survival rates and mean times to death. These results demonstrated that Aeromonas phage PAS-1 could be considered as an alternative biological control agent against A. salmonicida subsp. salmonicida infections in rainbow trout culture. © 2013 Blackwell Verlag GmbH.

  14. Recognition of Faux Pas by Normally Developing Children and Children with Asperger Syndrome or High-Functioning Autism.

    Science.gov (United States)

    Baron-Cohen, Simon; O'Riordan, Michelle; Stone, Valerie; Jones, Rosie; Plaisted, Kate

    1999-01-01

    This article describes a test of theory of mind for children, ages 7-11, that involved recognition of faux pas. Three studies used the test with children with high functioning autism (HFA) or Asperger syndrome (AS). Results indicated that children with HFA or AS were significantly impaired on this task when compared to normally developing…

  15. Qu'en est-il des élèves qui ne travaillent pas à la maison ?

    OpenAIRE

    Brès, Jean-Claude; Capitanescu Benetti, Andreea; Vellas, Etiennette

    2017-01-01

    Ce n’est pas parce que le travail à la maison est différent que tous les élèves le font. À partir d’échanges avec des enseignants pratiquant la classe inversée, les auteurs nous proposent des éléments de réflexion sur cette question.

  16. Toxins vapC and pasB from prokaryotic TA modules remain active in mammalian cancer cells.

    Science.gov (United States)

    Wieteska, Łukasz; Skulimowski, Aleksander; Cybula, Magdalena; Szemraj, Janusz

    2014-09-30

    Among the great number of addictive modules which have been discovered, only a few have been characterized. However, research concerning the adoption of toxins from these systems shows their great potential as a tool for molecular biology and medicine. In our study, we tested two different toxins derived from class II addictive modules, pasAB from plasmid pTF-FC2 (Thiobacillus ferrooxidans) and vapBC 2829Rv (Mycobacterium tuberculosis), in terms of their usefulness as growth inhibitors of human cancer cell lines, namely KYSE 30, MCF-7 and HCT 116. Transfection of the pasB and vapC genes into the cells was conducted with the use of two different expression systems. Cellular effects, such as apoptosis, necrosis and changes in the cell cycle, were tested by applying flow cytometry with immunofluorescence staining. Our findings demonstrated that toxins VapC and PasB demonstrate proapoptotic activity in the human cancer cells, regardless of the expression system used. As for the toxin PasB, observed changes were more subtle than for the VapC. The level of expression for both the genes was monitored by QPCR and did not reveal statistically significant differences within the same cell line.

  17. Partai Islam Se-Malaysia (PAS dan Partai Keadilan Sejahtera (PKS sebagai Partai Islam Pendukung Demokrasi PKS Pada Pemilu

    Directory of Open Access Journals (Sweden)

    Ahmad Ali Nurdin

    2015-11-01

    Full Text Available The article compares the achievement of Partai Islam se-Malaysia (PAS and Partai Keadilan Sejahtera (PKS in the latest general election held in 2013 in Malaysia and in 2014 in Indonesia. The writer finds that the political performance of PAS and PKS has indicated differently contrast results. While political electability of PAS in the 2013 Malaysia’s general election has disappointed this party, PKS has successfully proved that surveys held by a number of survey institutes—predicting that the party would cease within the 2014 Indonesia’s national election—were totally false. Many political figures of PAS have failed to gain positions in the legislative assembly. Meanwhile, in viewing PKS’s political performance during the 2014 national election, one may assume that this party was luckily survive. This is because, a number of surveys conducted before the election had predicted that PKS could be considered lucky when it was able to gain five percent of vote, as its former president has been suspected of being corrupt for his involvement in cows import. However, the fact shows that PKS has not only magnificently survived but it was even able to gain almost seven percent of voters’ vote. Unfortunately, PKS was unsuccessful to achieve its political target to be the biggest three of national vote.

  18. Crystallization and preliminary crystallographic data of the PAS domain of the NifL protein from Azotobacter vinelandii.

    NARCIS (Netherlands)

    Hefti, M.H.; Hendle, J.; Enroth, C.; Vervoort, J.J.M.; Tucker, P.A.

    2001-01-01

    The Azotobacter vinelandii NifL protein is a redox-sensing flavoprotein which inhibits the activity of the nitrogen-specific transcriptional activator NifA. The N-terminal PAS domain has been overexpressed in Escherichia coli and crystallized by the hanging-drop vapour-diffusion method. The crystal

  19. Gas Sensing and Signaling in the PAS-Heme Domain of the Pseudomonas aeruginosa Aer2 Receptor.

    Science.gov (United States)

    Garcia, Darysbel; Orillard, Emilie; Johnson, Mark S; Watts, Kylie J

    2017-09-15

    The Aer2 chemoreceptor from Pseudomonas aeruginosa contains a PAS sensing domain that coordinates b-type heme and signals in response to the binding of O2, CO, or NO. PAS-heme structures suggest that Aer2 uniquely coordinates heme via a His residue on a 310 helix (H234 on Eη), stabilizes O2 binding via a Trp residue (W283), and signals via both W283 and an adjacent Leu residue (L264). Ligand binding may displace L264 and reorient W283 for hydrogen bonding to the ligand. Here, we clarified the mechanisms by which Aer2-PAS binds heme, regulates ligand binding, and initiates conformational signaling. H234 coordinated heme, but additional hydrophobic residues in the heme cleft were also critical for stable heme binding. O2 appeared to be the native Aer2 ligand (dissociation constant [Kd ] of 16 μM). With one exception, mutants that bound O2 could signal, whereas many mutants that bound CO could not. W283 stabilized O2 binding but not CO binding, and it was required for signal initiation; W283 mutants that could not stabilize O2 were rapidly oxidized to Fe(III). W283F was the only Trp mutant that bound O2 with wild-type affinity. The size and nature of residue 264 was important for gas binding and signaling: L264W blocked O2 binding, L264A and L264G caused O2-mediated oxidation, and L264K formed a hexacoordinate heme. Our data suggest that when O2 binds to Aer2, L264 moves concomitantly with W283 to initiate the conformational signal. The signal then propagates from the PAS domain to regulate the C-terminal HAMP and kinase control domains, ultimately modulating a cellular response.IMPORTANCEPseudomonas aeruginosa is a ubiquitous environmental bacterium and opportunistic pathogen that infects multiple body sites, including the lungs of cystic fibrosis patients. P. aeruginosa senses and responds to its environment via four chemosensory systems. Three of these systems regulate biofilm formation, twitching motility, and chemotaxis. The role of the fourth system, Che2, is

  20. A novel signal transduction protein: Combination of solute binding and tandem PAS-like sensor domains in one polypeptide chain.

    Science.gov (United States)

    Wu, R; Wilton, R; Cuff, M E; Endres, M; Babnigg, G; Edirisinghe, J N; Henry, C S; Joachimiak, A; Schiffer, M; Pokkuluri, P R

    2017-04-01

    We report the structural and biochemical characterization of a novel periplasmic ligand-binding protein, Dret_0059, from Desulfohalobium retbaense DSM 5692, an organism isolated from Lake Retba, in Senegal. The structure of the protein consists of a unique combination of a periplasmic solute binding protein (SBP) domain at the N-terminal and a tandem PAS-like sensor domain at the C-terminal region. SBP domains are found ubiquitously, and their best known function is in solute transport across membranes. PAS-like sensor domains are commonly found in signal transduction proteins. These domains are widely observed as parts of many protein architectures and complexes but have not been observed previously within the same polypeptide chain. In the structure of Dret_0059, a ketoleucine moiety is bound to the SBP, whereas a cytosine molecule is bound in the distal PAS-like domain of the tandem PAS-like domain. Differential scanning flourimetry support the binding of ligands observed in the crystal structure. There is significant interaction between the SBP and tandem PAS-like domains, and it is possible that the binding of one ligand could have an effect on the binding of the other. We uncovered three other proteins with this structural architecture in the non-redundant sequence data base, and predict that they too bind the same substrates. The genomic context of this protein did not offer any clues for its function. We did not find any biological process in which the two observed ligands are coupled. The protein Dret_0059 could be involved in either signal transduction or solute transport. © 2017 The Protein Society.

  1. Introduction to Nematode Genome and Transcriptome Announcements in the Journal of Nematology.

    Science.gov (United States)

    Denver, Dee R; Ragsdale, Erik J; Thomas, W Kelley; Zasada, Inga A

    2017-06-01

    The Journal of Nematology now offers publication of Nematode Genome Announcements (NGA) and Nematode Transcriptome Announcements (NTA). These brief reports announce the sequencing and assembly of a nematode genome or transcriptome resource, along with basic technical information on DNA sequencing and bioinformatic methods used. This publishing initiative offers a new avenue to openly and concisely communicate the availability and relevance of genome and transcriptome sequence resources to the broader scientific community.

  2. Introduction to Nematode Genome and Transcriptome Announcements in the Journal of Nematology

    OpenAIRE

    Denver, Dee R.; Ragsdale, Erik J.; Thomas, W. Kelley; ZASADA, INGA A

    2017-01-01

    The Journal of Nematology now offers publication of Nematode Genome Announcements (NGA) and Nematode Transcriptome Announcements (NTA). These brief reports announce the sequencing and assembly of a nematode genome or transcriptome resource, along with basic technical information on DNA sequencing and bioinformatic methods used. This publishing initiative offers a new avenue to openly and concisely communicate the availability and relevance of genome and transcriptome sequence resources to the...

  3. The neuronal PAS domain protein 4 (Npas4 is required for new and reactivated fear memories.

    Directory of Open Access Journals (Sweden)

    Jonathan E Ploski

    Full Text Available The Neuronal PAS domain protein 4 (Npas4 is a neuronal activity-dependent immediate early gene that has recently been identified as a transcription factor which regulates the transcription of genes that control inhibitory synapse development and synaptic plasticity. The role Npas4 in learning and memory, however, is currently unknown. Here, we systematically examine the role of Npas4 in auditory Pavlovian fear conditioning, an amygdala-dependent form of emotional learning. In our first series of experiments, we show that Npas4 mRNA and protein are regulated in the rat lateral nucleus of the amygdala (LA in a learning-dependent manner. Further, knockdown of Npas4 protein in the LA via adeno-associated viral (AAV mediated gene delivery of RNAi was observed to impair fear memory formation, while innate fear and the expression of fear memory were not affected. In our second series of experiments, we show that Npas4 protein is regulated in the LA by retrieval of an auditory fear memory and that knockdown of Npas4 in the LA impairs retention of a reactivated, but not a non-reactivated, fear memory. Collectively, our findings provide the first comprehensive look at the functional role of Npas4 in learning and memory.

  4. Fossil Vertebrate Database from Cova des Pas de Vallgornera (Llucmajor, Mallorca

    Directory of Open Access Journals (Sweden)

    Anna Díaz

    2014-05-01

    Full Text Available The data set presented in this paper includes the fossil fauna collected in the cave named Cova des Pas de Vallgornera (CPV, located on the southern coast of Mallorca (Balearic Islands, Spain. It holds 1481 catalogued items, 97.5% identified at species level. Mammalia, Aves, Reptilia, and Amphibia are represented in the Database. The fauna collected in the cave includes the three endemic mammals present on Mallorca during the Early Pleistocene (Myotragus aff. kopperi, Hypnomys onicensis, and Nesiotites aff. ponsi. There are also represented two taxa of Chiroptera (Rhinolophus aff. mehelyi and Pipistrellus sp., 16 taxa of birds (6 of them identified at species level, one Reptilian taxon (Podarcis sp. and one Amphibian taxon (Discoglossus sp.. Most of fossils were collected during a single excavation campaign of 3 days (28-30th May, 2010. A few remains were obtained in two previous visits to the cave, in 2006 and 2009. All the specimens are curated and documented at the Vertebrate Collection of the IMEDEA [Institut Mediterrani d'Estudis Avançats (CSIC-UIB]. The assemblage of CPV fossils is a part of the paleontological collection IMEDEA-PALEOVERT, included at the GBIF portal.

  5. Innovative Molecular Analysis Technologies Program Funding Opportunities | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The NCI is very pleased to announce that the Innovative Molecular Analysis Technologies (IMAT) program funding opportunity announcements have been posted for calendar year (CY) 2013. Please visit this website for more information on these announcements. For your convenience, a link to each solicitation is provided below with associated submission deadlines for new applications and resubmissions. Please contact the NCI IMAT program director, Dr.

  6. Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

    Science.gov (United States)

    Ke, Ying; Ng, Chai Ann; Hunter, Mark J; Mann, Stefan A; Heide, Juliane; Hill, Adam P; Vandenberg, Jamie I

    2013-08-15

    Loss of Kv11.1 potassium channel function is the underlying cause of pathology in long-QT syndrome type 2, one of the commonest causes of sudden cardiac death in the young. Previous studies have identified the cytosolic PAS (Per/Arnt/Sim) domain as a hotspot for mutations that cause Kv11.1 trafficking defects. To investigate the underlying basis of this observation, we have quantified the effect of mutants on domain folding as well as interactions between the PAS domain and the remainder of the channel. Apart from R56Q, all mutants impaired the thermostability of the isolated PAS domain. Six mutants, located in the vicinity of a hydrophobic patch on the PAS domain surface, also affected binding of the isolated PAS domain to an N-terminal truncated hERG (human ether-a-go-go-related gene) channel. Conversely, four other surface mutants (C64Y, T65P, A78P and I96T) and one buried mutant (L86R) did not prevent the isolated PAS domain binding to the truncated channels. Our results highlight a critical role for interactions between the PAS domain and the remainder of the channel in the hERG assembly and that mutants that affect PAS domain interactions with the remainder of the channel have a more severe trafficking defect than that caused by domain unfolding alone.

  7. Power of the policy: how the announcement of high-stakes clinical examination altered OSCE implementation at institutional level

    Directory of Open Access Journals (Sweden)

    Lin Chi-Wei

    2013-01-01

    Full Text Available Abstract Background The Objective Structured Clinical Examination (OSCE has been widely applied as a high-stakes examination for assessing physicians’ clinical competency. In 1992, OSCE was first introduced in Taiwan, and the authorities announced that passing the OSCE would be a prerequisite for step-2 medical licensure examination in 2013. This study aimed to investigate the impacts of the announced national OSCE policy on implementation of OSCE at the institutional level. Further, the readiness and the recognition of barriers toward a high-stakes examination were explored. Methods In 2007 and 2010, the year before and after the announcement of high-stakes OSCE policy in 2008, respectively, questionnaires on the status of OSCE implementation were distributed to all hospitals with active OSCE programs in Taiwan. Information on OSCE facilities, equipment, station length, number of administrations per year, and the recognition of barriers to the success of implementing an OSCE were collected. The missing data were completed by telephone interviews. The OSCE format, administration, and facilities before and after the announcement of the nationwide OSCE policy were compared. Results The data were collected from 17 hospitals in 2007 and 21 in 2010. Comparing the OSCE formats between 2007 and 2010, the number of stations increased and the station length decreased. The designated space and the equipment for OSCE were also found to have been improved. As for the awareness of OSCE implementation barriers, the hospital representatives concerned mostly about the availability and quality of standardized patients in 2007, as well as space and facilities in 2010. Conclusions The results of this study underscored an overall increase in the number of OSCE hospitals and changes in facilities and formats. While recruitment and training of standardized patients were the major concerns before the official disclosure of the policy, space and facilities became the

  8. 76 FR 12127 - Emergency Homeowners' Loan Program: Announcement of Activation of Program and Availability of...

    Science.gov (United States)

    2011-03-04

    ... note,\\1\\ must have a total pre-Event income equal to, or less than, 120 percent of the area median..., interest, taxes, insurance, and revolving and fixed installment debt divided by total monthly income). For... relocation expenses. Net proceeds shall go towards satisfying the EHLP Note. In the event that net proceeds...

  9. 77 FR 48527 - National Customs Automation Program (NCAP) Test Concerning Automated Commercial Environment (ACE...

    Science.gov (United States)

    2012-08-14

    ... SECURITY U.S. Customs and Border Protection National Customs Automation Program (NCAP) Test Concerning...: General notice. SUMMARY: This notice announces modifications to the National Customs Automation Program...) National Customs Automation Program (NCAP) test concerning Automated Commercial Environment (ACE...

  10. [Alcohol and psychotropic drugs in fatal traffic accidents (the Nord-Pas-de-Calais region, France)].

    Science.gov (United States)

    Deveaux, M; Marson, J C; Goldstein, P; Lhermitte, M; Gosset, D; Muller, P H

    1990-01-01

    Consumption of alcohol and tranquilizers reaches a very high level in France. Studies about simultaneous alcohol and psychotropic drugs involvement in motor related fatalities have never been described in this country. A retrospective study was done on 482 fatalities broken down by drivers and pedestrians within one year (1987) in Région Nord-Pas de Calais (France). 132 cases met the criteria for complete study. Blood samples obtained at the time of death were analysed for alcohol (BAC) by gas-chromatography and assayed for barbiturates (BA), benzodiazepines (BE) and tricyclic antidepressants (TA) by Emit. Out of 132 fatalities there were 86% men (mean age 38.5 years) and 14% women (mean age 46 years). 57% belonged to the working population. Of the fatalities, 38% occurred from Friday 8 p.m. to Sunday 12 p.m. We distinguished 3 categories: pedestrians (18.2%), 2-wheel vehicles (19%) and 4-wheel vehicles (62.8%). Alcohol involvement is given in Table 2. [table: see text] Notice that 53% were above the legal limit (0.8 g/l) and 34.8% had no alcohol. Psychotropic drugs were detected in 10.6% of the cases (Table 3). [table: see text] BZ were found in 50% of men and 100% of women. drugs and alcohol were present simultaneously in 8.3% of the individuals. Results are in % of total in Table 4: [table: see text] Positive BAC and positive drugs are not related. No significant difference was found in the distribution of alcohol between positive or negative drugs findings. Our results are consistent with those described by North-American authors, but largely superior to those from French or other studies done only on injured persons.

  11. Announcing the Sociation Today Urban Sociology and Reprint Collection Series

    Directory of Open Access Journals (Sweden)

    George H. Conklin

    2007-11-01

    Full Text Available "Sociation Today" is happy to announce the Urban Sociology Reprint Series. Other reprints will be focused on DuBois and his work available on-line, while the Max Weber video now has its own page. Articles printed in the current and past issues of Sociation Today have been gathered together in one place so they can be viewed conviently. The MENU link to the left will direct you to the proper place, as will the link above (for the urban reprints. The files will enable you to see the articles on a specific topic in one place, and also will enable the professor to assign the articles easily in classes. As an open access journal, Sociation Today's goal remains to provide scholars, the public and students with refereed articles exploring the nature of society and its interactions at no charge, unlike traditional journals and JSTOR.

  12. Effects of frequent announced parasitology quizzes on the academic achievement.

    Directory of Open Access Journals (Sweden)

    Ghasem Zamini

    2013-12-01

    Full Text Available The effect of frequent examinations on the students' learning has had inconsistent results. This study aimed to assess the effectiveness of frequent announced quizzes on the learning of a representative sample of Iranian medical students.This experimental study was conducted among 37 fifth semester medical students who had taken the course in Protozoology and Helminthology, in which the same basic information were provided about different types of protozoa and worms. Initially, in the teaching of helminthology, ten routine sessions were handled with lectures and interactive questions and answers. Then at the beginning of the protozoology topic in the beginning of all of the next 9 sessions, the students were informed that they will have a quiz at the end of each session. At the end of the semester, the total scores of quizzes were compared with the mean final scores of protozoology and helminthology using paired t and repeated measure tests.The mean final scores of the protozoology lesson were not significantly different from that of the helminthology (10.45 ± 2.75 vs.11.25 ± 2.56 on the scale of 20, respectively, P=0.13. There was no significant difference in the mean score of the five quizzes compared with the mean final term score of protozoology. The overall mean scores in the helminthology lesson (11.25±2.56, protozoology lesson (10.45±2.75, and the quizzes (9.16 ± 3.55 were significantly different (P <0.0001.Frequent announced quizzes were not effective on increasing the medical students' motivation and learning.

  13. 76 FR 58332 - Announcement of Meeting of the International Telecommunication Advisory Committee

    Science.gov (United States)

    2011-09-20

    ... Announcement of Meeting of the International Telecommunication Advisory Committee Summary: This notice announces a meeting of the International Telecommunication Advisory Subcommittees (ITAC) on October 6, 2011... advice from the telecommunications industry on (a) whether the U.S. should agree that Study Group 15's...

  14. 7 CFR 1124.53 - Announcement of class prices, component prices, and advanced pricing factors.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Announcement of class prices, component prices, and advanced pricing factors. 1124.53 Section 1124.53 Agriculture Regulations of the Department of Agriculture... Announcement of class prices, component prices, and advanced pricing factors. See § 1000.53. ...

  15. 20 CFR 625.17 - Announcement of the beginning of a Disaster Assistance Period.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Announcement of the beginning of a Disaster Assistance Period. 625.17 Section 625.17 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR DISASTER UNEMPLOYMENT ASSISTANCE § 625.17 Announcement of the beginning of a Disaster Assistance Period. Whenever a major disaste...

  16. 77 FR 9889 - Black Hills National Forest Advisory Board Public Meeting Dates Announced

    Science.gov (United States)

    2012-02-21

    ... Forest Service Black Hills National Forest Advisory Board Public Meeting Dates Announced AGENCY: Forest...) has announced its meeting dates for 2012. These meetings are open to the public, and public comment is... meeting, limited to three (3) minutes per person for oral comments. Meeting dates are the third Wednesday...

  17. 75 FR 78209 - Black Hills National Forest Advisory Board Public Meeting Dates Announced

    Science.gov (United States)

    2010-12-15

    ... Forest Service Black Hills National Forest Advisory Board Public Meeting Dates Announced AGENCY: Forest...) has announced its meeting dates for 2011. These meetings are open to the public, and public comment is... meeting, limited to three (3) minutes per person for oral comments. Meeting dates are the third Wednesday...

  18. Perceived Effectiveness of Weekly Announcements in Provision of Learning Support to Sociology Students

    Science.gov (United States)

    Jabeen, Sadia

    2015-01-01

    Announcements are considered as important source in provision of academic support to the students. Announcements assist students to get information about the university learning mechanisms, courses and other time management skills, which may help them to make their learning smooth and pleasant. In this context present study documents the perceived…

  19. 75 FR 76982 - Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches...

    Science.gov (United States)

    2010-12-10

    ... AGENCY Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches for... literature searches for IRIS assessments; request for information. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing the availability of literature searches for four IRIS assessments...

  20. 76 FR 13402 - Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches...

    Science.gov (United States)

    2011-03-11

    ... AGENCY Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches for... literature searches for IRIS assessments; request for information. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing the availability of literature searches for cobalt (CASRN 7440-48-4) and...

  1. 75 FR 25239 - Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches...

    Science.gov (United States)

    2010-05-07

    ... AGENCY Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches for... of literature searches for IRIS assessments; request for information. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing the availability of literature searches for four IRIS assessments and...

  2. 77 FR 41784 - Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches...

    Science.gov (United States)

    2012-07-16

    ... AGENCY Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches for... literature search for benzo(a)pyrene; request for information. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing the availability of a literature search for benzo(a)pyrene (CASRN 50- 32-8...

  3. 77 FR 20817 - Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches...

    Science.gov (United States)

    2012-04-06

    ... AGENCY Integrated Risk Information System (IRIS); Announcement of Availability of Literature Searches for... literature searches for IRIS assessments; request for information. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing the availability of literature searches for acetaldehyde (75-07-0) and 1,2,3...

  4. 77 FR 58511 - Announcement of Competition Under the America COMPETES Reauthorization Act of 2011

    Science.gov (United States)

    2012-09-21

    ... visualization competition will receive one thousand dollars as a prize. (c) The evaluation metric that forms the... Bureau of the Census Announcement of Competition Under the America COMPETES Reauthorization Act of 2011 AGENCY: Bureau of the Census, Commerce. ACTION: Notice of competition announcement. SUMMARY: The Census...

  5. 75 FR 62684 - Health Insurance Reform; Announcement of Maintenance Changes to Electronic Data Transaction...

    Science.gov (United States)

    2010-10-13

    ... HUMAN SERVICES Office of the Secretary 45 CFR Part 162 RIN 0938-AM50 Health Insurance Reform; Announcement of Maintenance Changes to Electronic Data Transaction Standards Adopted Under the Health Insurance...: This document announces maintenance changes to some of the Health Insurance Portability and...

  6. 47 CFR 61.193 - Vacation of suspension order; supplements announcing same; etc.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Vacation of suspension order; supplements announcing same; etc. 61.193 Section 61.193 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED...; supplements announcing same; etc. If the Commission vacates a suspension order, the affected carrier must...

  7. 76 FR 65743 - Announcement of Funding Awards; Capital Fund Education and Training Community Facilities (CFCF...

    Science.gov (United States)

    2011-10-24

    ... URBAN DEVELOPMENT Announcement of Funding Awards; Capital Fund Education and Training Community... the Department of Housing and Urban Development Reform Act of 1989, this announcement notifies the... of Public Housing, Department of Housing and Urban Development, 451 7th Street, SW., Room 4130...

  8. 48 CFR 1805.303 - Announcement of contract awards. (NASA supplements paragraph (a))

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Announcement of contract awards. (NASA supplements paragraph (a)) 1805.303 Section 1805.303 Federal Acquisition Regulations System... ACTIONS Synopses of Contract Awards 1805.303 Announcement of contract awards. (NASA supplements paragraph...

  9. 76 FR 17626 - National Climate Assessment Development and Advisory Committee; Announcement of Time Change and...

    Science.gov (United States)

    2011-03-30

    ... announces a change in the start time and provides the location of the meeting of the National Climate... National Oceanic and Atmospheric Administration National Climate Assessment Development and Advisory Committee; Announcement of Time Change and Meeting Location AGENCY: National Oceanic and Atmospheric...

  10. 78 FR 12063 - Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge; Correction

    Science.gov (United States)

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge... Register of December 6, 2012, announcing the requirements and criteria for the healthfinder.gov Mobile App...

  11. A Job Announcement Analysis of Educational Technology Professional Positions: Knowledge, Skills, and Abilities

    Science.gov (United States)

    Kang, YoungJu; Ritzhaupt, Albert D.

    2015-01-01

    The purpose of this research was to identify the competencies of an educational technologist via a job announcement analysis. Four hundred job announcements were collected from a variety of online job databases over a 5-month period. Following a systematic process of collection, documentation, and analysis, we derived over 150 knowledge, skill,…

  12. 77 FR 26511 - Announcing a National Cybersecurity Center of Excellence (NCCoE) Workshop

    Science.gov (United States)

    2012-05-04

    ... National Institute of Standards and Technology Announcing a National Cybersecurity Center of Excellence.... ACTION: Notice of initial public workshop. SUMMARY: NIST announces a National Cybersecurity Center of... integrated cybersecurity tools and technologies. The NCCoE will bring together experts from industry...

  13. 75 FR 76009 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2010-12-07

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Announcement of Office of Management and Budget Approval; Electronic Products--General Requirements AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that a...

  14. Molecular Mechanisms of Transcription Activation by Juvenile Hormone: A Critical Role for bHLH-PAS and Nuclear Receptor Proteins

    Directory of Open Access Journals (Sweden)

    Edward B. Dubrovsky

    2012-03-01

    Full Text Available Juvenile hormone (JH is responsible for controlling many biological processes. In several insect species JH has been implicated as a key regulator of developmental timing, preventing the premature onset of metamorphosis during larval growth periods. However, the molecular basis of JH action is not well-understood. In this review, we highlight recent advances which demonstrate the importance of transcription factors from the bHLH-PAS and nuclear receptor families in mediating the response to JH.

  15. A Comparative Analysis between GaN-Based Current and Voltage Mode Class-D and E PAs for Communications

    Science.gov (United States)

    2017-03-01

    A Comparative Analysis between GaN-Based Current and Voltage Mode Class-D and E PAs for Communications Shishir Shukla and Jennifer Kitchen...programmability and efficiency. Radar and imaging systems that use constant envelope waveforms may exploit the advantages of highly nonlinear, or switched...709–717, Dec 2005. 7. T. Suetsugu and M. K. Kazimierczuk, “Off-Nominal Operation of Class-E Amplifier at Any Duty Ratio ,” IEEE Transactions on

  16. 76 FR 64043 - Iowa Regulatory Program

    Science.gov (United States)

    2011-10-17

    ... Office of Surface Mining Reclamation and Enforcement 30 CFR Part 915 Iowa Regulatory Program AGENCY...), are announcing receipt of a proposed amendment to the Iowa regulatory program (Iowa program) under the... regulatory program by updating its adoption by reference of applicable portions of the Code of Federal...

  17. 76 FR 21753 - Site Tours Program

    Science.gov (United States)

    2011-04-18

    ... HUMAN SERVICES Food and Drug Administration Site Tours Program AGENCY: Food and Drug Administration, HHS... announcing a notice for participation in its Site Tours Program. This program is intended to give CTP staff... parties interested in participating in the Site Tours Program to submit requests to CTP. DATES: Interested...

  18. All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes.

    Science.gov (United States)

    Sabatini, Paul V; Lynn, Francis C

    2015-01-01

    As a sensory micro-organ, pancreatic β-cells continually respond to nutritional signals and neuroendocrine input from other glucoregulatory organs. This sensory ability is essential for normal β-cell function and systemic glucose homeostasis. Period circadian protein (Per)-aryl hydrocarbon receptor nuclear translocator protein (Arnt)-single-minded protein (Sim) (PAS) domain proteins have a conserved role as sensory proteins, critical in adaptation to changes in voltage, oxygen potential, and xenobiotics. Within β-cells, PAS domain proteins such as hypoxia inducible factor 1α (Hif1α), Arnt, PAS kinase, Bmal1, and Clock respond to disparate stimuli, but act in concert to maintain proper β-cell function. Elucidating the function of these factors in islets offers a unique insight into the sensing capacity of β-cells, the consequences of impaired sensory function, and the potential to develop novel therapeutic targets for preserving β-cell function in diabetes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Mapping potential freshwater services, and their representation within Protected Areas (PAs, under conditions of sparse data. Pilot implementation for Cambodia

    Directory of Open Access Journals (Sweden)

    Leonardo Sáenz

    2016-07-01

    Full Text Available Freshwater is arguably one of Earth’s most threatened natural resources, on which more than 7 billion people depend. Pressures on freshwater resources from infrastructure, resource development, agricultural pollution and deforestation are mounting, particularly in developing countries. To date, conservation responses such as Protected Areas (PAs have not typically targeted freshwater ecosystems and their services, and thus little is known about the effectiveness of these efforts in protecting them. This paper proposes and pilots an innovative freshwater services metrics framework to quantify the representation of potential freshwater services in PAs under conditions of scarce data, with a pilot application for Cambodia. Our results indicate that conservation actions have more effectively represented potential freshwater regulation services than potential freshwater provisioning services, with major rivers remaining generally unprotected. Results from the framework are then used to propose a series of context and region specific management options to improve the conservation of freshwater services in Cambodia. There is an acute need for such management options, as the country’s food security depends largely on important freshwater ecosystems such as the Tonle Sap Lake and the deep water pools systems of the Mekong River. The framework proposed can be applied in other countries or large river basins to explore the degree of representation of freshwater services within PAs systems, under conditions of sparse data.

  20. Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.

    Science.gov (United States)

    Militi, Stefania; Maywood, Elizabeth S; Sandate, Colby R; Chesham, Johanna E; Barnard, Alun R; Parsons, Michael J; Vibert, Jennifer L; Joynson, Greg M; Partch, Carrie L; Hastings, Michael H; Nolan, Patrick M

    2016-03-08

    The suprachiasmatic nucleus (SCN) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation of Per (period) and Cry (cryptochrome) genes by BMAL1-CLOCK complexes is suppressed by PER-CRY complexes. The molecular/structural basis of how circadian protein complexes function is poorly understood. We describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324N) that accelerates the circadian clock of Per2(Edo/Edo) mice by 1.5 h. Structural and biophysical analyses revealed that Edo alters the packing of the highly conserved interdomain linker of the PER2 PAS core such that, although PER2(Edo) complexes with clock proteins, its vulnerability to degradation mediated by casein kinase 1ε (CSNK1E) is increased. The functional relevance of this mutation is revealed by the ultrashort (Edo/Edo); Csnk1e(Tau/Tau) mice and the SCN. These periods are unprecedented in mice. Thus, Per2(Edo) reveals a direct causal link between the molecular structure of the PER2 PAS core and the pace of SCN circadian timekeeping.

  1. Your Way to a Better Theory of Mind: A Healthy Diet Relates to Better Faux Pas Recognition in Older Adults.

    Science.gov (United States)

    Ruffman, Ted; Zhang, Julie; Taumoepeau, Mele; Skeaff, Sheila

    2016-01-01

    Aging is characterized by a well-documented worsening of general cognition, and also a decline in social understanding such as the ability to recognize emotions or detect socially inappropriate behavior (faux pas). Several studies have demonstrated that lifestyle factors (diet, exercise, social integration, smoking) tend to offset general cognitive decline, and we examined whether they also help to offset age-related declines in social cognition. There were 56 participants aged 60 years or over. General cognition was measured using a matrices task and the Mini-Mental State Examination (MMSE). Emotion recognition was measured by the matching of faces to emotion sounds and bodies to sounds. Faux pas recognition was measured by 16 videos, examining participants' ability to differentiate appropriate and inappropriate social behavior. Diet, exercise, social integration, and smoking habits were measured via questionnaires. For general cognition, diet, pr = .32, p diet explained independent variance in the ability to identify appropriate social behavior, pr = .29, p = .04. We replicated previous research in finding that lifestyle factors were related to fluid intelligence. In addition, we obtained the novel finding that a healthy diet is associated with better recognition of faux pas in older adults, likely acting through facilitation of brain health, and providing initial support for a means of enhancing social functioning and well-being in old age.

  2. Interservice Physician Assistant Program: Educators for an Expanding Profession.

    Science.gov (United States)

    Brock, Douglas M; Orrahood, Scott A; Cooper, Christopher K; Alvitre, John J; Tozier, William

    2017-10-01

    The number of physician assistant (PA) programs has increased exponentially across the past decade, and the demand for PAs will likely remain strong through 2025. Because of this rapid growth, both new and established PA programs face significant challenges in recruiting experienced educators. We describe the value of using PAs trained through the Interservice Physician Assistant Program (IPAP) as civilian PA educators. The literature on IPAP and its graduates proved too limited to conduct a formal systematic review. We searched the PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases for works speaking to the value that IPAP-trained PAs may bring to civilian PA training. Those findings were supplemented with informal conversations with IPAP-trained PAs currently employed in the military and those working in civilian PA education. Themes were identified supporting the potential value of IPAP-trained PAs in civilian training. Military PAs work within hierarchical organizations and may transition easily to academic settings. They leave military service not only as highly trained and proficient primary care providers but also as experienced educators. Military PAs must demonstrate professionalism across their entire military careers. They serve as leaders and work in teams, but they are also experienced in negotiating up chains of command. They are trained in and apply the latest innovations in health care delivery and have provided care with a degree of autonomy uncommon in civilian PA practice. The PAs trained through IPAP leave the service with skills and experiences valuable to civilian PA training. Employing these PAs in civilian education honors their service contributions while addressing emerging PA educator workforce demands.

  3. Role of the Cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) Domain in Trafficking and Stabilization of Kv11.1 Channels*

    Science.gov (United States)

    Ke, Ying; Hunter, Mark J.; Ng, Chai Ann; Perry, Matthew D.; Vandenberg, Jamie I.

    2014-01-01

    The N-terminal cytoplasmic region of the Kv11.1a potassium channel contains a Per-Arnt-Sim (PAS) domain that is essential for the unique slow deactivation gating kinetics of the channel. The PAS domain has also been implicated in the assembly and stabilization of the assembled tetrameric channel, with many clinical mutants in the PAS domain resulting in reduced stability of the domain and reduced trafficking. Here, we use quantitative Western blotting to show that the PAS domain is not required for normal channel trafficking nor for subunit-subunit interactions, and it is not necessary for stabilizing assembled channels. However, when the PAS domain is present, the N-Cap amphipathic helix must also be present for channels to traffic to the cell membrane. Serine scan mutagenesis of the N-Cap amphipathic helix identified Leu-15, Ile-18, and Ile-19 as residues critical for the stabilization of full-length proteins when the PAS domain is present. Furthermore, mutant cycle analysis experiments support recent crystallography studies, indicating that the hydrophobic face of the N-Cap amphipathic helix interacts with a surface-exposed hydrophobic patch on the core of the PAS domain to stabilize the structure of this critical gating domain. Our data demonstrate that the N-Cap amphipathic helix is critical for channel stability and trafficking. PMID:24695734

  4. Comparison of haemostatic function of PAS-C-platelets vs. plasma-platelets in reconstituted whole blood using impedance aggregometry and thromboelastography.

    Science.gov (United States)

    van Hout, F M A; Bontekoe, I J; de Laleijne, L A E; Kerkhoffs, J-L; de Korte, D; Eikenboom, J; van der Bom, J G; van der Meer, P F

    2017-08-01

    There are concerns about the haemostatic function of platelets stored in platelet additive solution (PAS). Aim of this study was to compare the haemostatic function of PAS-C-platelets to plasma-platelets in reconstituted whole blood. In our experiment, whole blood was reconstituted with red blood cells, solvent-detergent (SD) plasma and either PAS-C-platelets or plasma-platelets (n = 7) in a physiological ratio. On storage days 2, 5, 8 and 13, the agonist-induced aggregation (multiple electrode aggregometry), clot formation (thromboelastography) and agonist-induced CD62P responsiveness (flow cytometry) were measured. Samples with PAS-C-platelets showed significantly lower aggregation than plasma-platelets when induced with adenosine diphosphate, -6 U (95% confidence interval: -8; -4) or thrombin receptor-activating protein, -15 U (-19; -10). Also when activated with collagen and ristocetin, the PAS-C-platelets showed less aggregation, although not statistically significant. All samples with PAS-C-platelets showed significantly lower agonist-induced CD62P responsiveness than samples with plasma-platelets. However, there was no difference regarding all TEG parameters. Our findings demonstrate that the function - aggregation and CD62P responsiveness - of PAS-C-platelets in reconstituted whole blood is inferior to that of plasma-platelets, which may have implications in the setting of massive transfusions. © 2017 International Society of Blood Transfusion.

  5. Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.

    Science.gov (United States)

    Ke, Ying; Hunter, Mark J; Ng, Chai Ann; Perry, Matthew D; Vandenberg, Jamie I

    2014-05-16

    The N-terminal cytoplasmic region of the Kv11.1a potassium channel contains a Per-Arnt-Sim (PAS) domain that is essential for the unique slow deactivation gating kinetics of the channel. The PAS domain has also been implicated in the assembly and stabilization of the assembled tetrameric channel, with many clinical mutants in the PAS domain resulting in reduced stability of the domain and reduced trafficking. Here, we use quantitative Western blotting to show that the PAS domain is not required for normal channel trafficking nor for subunit-subunit interactions, and it is not necessary for stabilizing assembled channels. However, when the PAS domain is present, the N-Cap amphipathic helix must also be present for channels to traffic to the cell membrane. Serine scan mutagenesis of the N-Cap amphipathic helix identified Leu-15, Ile-18, and Ile-19 as residues critical for the stabilization of full-length proteins when the PAS domain is present. Furthermore, mutant cycle analysis experiments support recent crystallography studies, indicating that the hydrophobic face of the N-Cap amphipathic helix interacts with a surface-exposed hydrophobic patch on the core of the PAS domain to stabilize the structure of this critical gating domain. Our data demonstrate that the N-Cap amphipathic helix is critical for channel stability and trafficking. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. Low-dose radiation pretreatment improves survival of human ceiling culture-derived proliferative adipocytes (ccdPAs) under hypoxia via HIF-1 alpha and MMP-2 induction

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Naoki [Department of Plastic Surgery, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-city, Chiba, #260-8677 (Japan); Kubota, Yoshitaka, E-mail: kubota-cbu@umin.ac.jp [Department of Plastic Surgery, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-city, Chiba, #260-8677 (Japan); Kosaka, Kentarou; Akita, Shinsuke; Sasahara, Yoshitarou; Kira, Tomoe [Department of Plastic Surgery, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-city, Chiba, #260-8677 (Japan); Kuroda, Masayuki [Center for Advanced Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-city, Chiba, #260-8677 (Japan); Mitsukawa, Nobuyuki [Department of Plastic Surgery, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-city, Chiba, #260-8677 (Japan); Bujo, Hideaki [Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University, Sakura Medical Center, 564-1 Shimoshizu, Sakura-shi, Chiba, #285-8741 (Japan); Satoh, Kaneshige [Department of Plastic Surgery, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-city, Chiba, #260-8677 (Japan)

    2015-08-07

    Poor survival is a major problem of adipocyte transplantation. We previously reported that VEGF and MMPs secreted from transplanted adipocytes are essential for angiogenesis and adipogenesis. Pretreatment with low-dose (5 Gy) radiation (LDR) increased VEGF, MMP-2, and HIF-1 alpha mRNA expression in human ceiling culture-derived proliferative adipocytes (hccdPAs). Gene expression after LDR differed between adipose-derived stem cells (hASCs) and hccdPAs. Pretreatment with LDR improved the survival of hccdPAs under hypoxia, which is inevitable in the early stages after transplantation. Upregulation of VEGF and MMP-2 after LDR in hccdPAs is mediated by HIF-1 alpha expression. Our results suggest that pretreatment with LDR may improve adipocyte graft survival in a clinical setting through upregulation of VEGF and MMP-2 via HIF-1 alpha. - Highlights: • Ceiling culture-derived proliferative adipocytes (ccdPAs) react to radiation. • Low-dose radiation (LDR) pretreatment improves survival of ccdPAs under hypoxia. • Gene expression after LDR differs between ccdPAs and adipose-derived stem cells. • LDR-induced increase in MMP-2 and VEGF is dependent on HIF-1 alpha induction. • LDR pretreatment may improve the adipocyte graft survival rate in clinical settings.

  7. The PAS Domain-Containing Protein HeuR Regulates Heme Uptake in Campylobacter jejuni.

    Science.gov (United States)

    Johnson, Jeremiah G; Gaddy, Jennifer A; DiRita, Victor J

    2016-11-15

    Campylobacter jejuni is a leading cause of bacterially derived gastroenteritis. A previous mutant screen demonstrated that the heme uptake system (Chu) is required for full colonization of the chicken gastrointestinal tract. Subsequent work identified a PAS domain-containing regulator, termed HeuR, as being required for chicken colonization. Here we confirm that both the heme uptake system and HeuR are required for full chicken gastrointestinal tract colonization, with the heuR mutant being particularly affected during competition with wild-type C. jejuni Transcriptomic analysis identified the chu genes-and those encoding other iron uptake systems-as regulatory targets of HeuR. Purified HeuR bound the chuZA promoter region in electrophoretic mobility shift assays. Consistent with a role for HeuR in chu expression, heuR mutants were unable to efficiently use heme as a source of iron under iron-limiting conditions, and mutants exhibited decreased levels of cell-associated iron by mass spectrometry. Finally, we demonstrate that an heuR mutant of C. jejuni is resistant to hydrogen peroxide and that this resistance correlates to elevated levels of catalase activity. These results indicate that HeuR directly and positively regulates iron acquisition from heme and negatively impacts catalase activity by an as yet unidentified mechanism in C. jejuni IMPORTANCE: Annually, Campylobacter jejuni causes millions of gastrointestinal infections in the United States, due primarily to its ability to reside within the gastrointestinal tracts of poultry, where it can be released during processing and contaminate meat. In the developing world, humans are often infected by consuming contaminated water or by direct contact with livestock. Following consumption of contaminated food or water, humans develop disease that is characterized by mild to severe diarrhea. There is a need to understand both colonization of chickens, to make food safer, and colonization of humans, to better

  8. An immunodiagnostic assay for quantitation of specific IgE to the major pollen allergen component, Pas n 1, of the subtropical Bahia grass.

    Science.gov (United States)

    Timbrell, Victoria L; Riebelt, Lindsay; Simmonds, Claire; Solley, Graham; Smith, William B; Mclean-Tooke, Andrew; van Nunen, Sheryl; Smith, Peter K; Upham, John W; Langguth, Daman; Davies, Janet M

    2014-01-01

    Pollens of the Panicoideae subfamily of grasses including Bahia (Paspalum notatum) are important allergen sources in subtropical regions of the world. An assay for specific IgE to the major molecular allergenic component, Pas n 1, of Bahia grass pollen (BaGP) would have immunodiagnostic utility for patients with pollen allergy in these regions. Biotinylated Pas n 1 purified from BaGP was coated onto streptavidin ImmunoCAPs. Subjects were assessed by clinical history of allergic rhinitis and skin prick test (SPT) to aeroallergens. Serum total, BaGP-specific and Pas n 1-specific IgE were measured. Pas n 1 IgE concentrations were highly correlated with BaGP SPT (r = 0.795, p Pas n 1 IgE, the diagnostic sensitivity (92.4%) and specificity (93.1%) for the detection of BaGP allergy was high (area under receiver operator curve 0.960, p Pas n 1 IgE in non-atopic subjects (0.01 kU/l, n = 67) and those with other allergies (0.02 kU/l, n = 59) showed no inter-group difference, whilst grass pollen-allergic patients with allergic rhinitis showed elevated Pas n 1 IgE (6.71 kU/l, n = 182, p Pas n 1 IgE appears to account for most of the BaGP-specific IgE. This molecular component immunoassay for Pas n 1 IgE has potential utility to improve the sensitivity and accuracy of diagnosis of BaGP allergy for patients in subtropical regions. © 2015 S. Karger AG, Basel.

  9. Heme-binding characteristics of the isolated PAS-B domain of mouse Per2, a transcriptional regulatory factor associated with circadian rhythms.

    Science.gov (United States)

    Hayasaka, Koya; Kitanishi, Kenichi; Igarashi, Jotaro; Shimizu, Toru

    2011-02-01

    Mouse period homolog 2 (mPer2), an important transcriptional regulatory factor associated with circadian rhythms, is composed of two N-terminal PAS (PAS-A and PAS-B) domains and a C-terminal domain. The PAS-A domain of mPer2 binds the heme iron via a Cys axial ligand. A corresponding transcriptional regulatory factor, neuronal PAS 2 protein (NPAS2), also contains PAS-A and PAS-B domains at the N-terminus with heme-binding capability. In particular, the PAS-B domain appears important for protein-protein interactions critical for transcriptional regulation. In the present study, we examined the heme-binding characteristics of the isolated PAS-B domain of mPer2. Our experiments show that the Fe(III) heme binds the isolated PAS-B domain with a heme to protein stoichiometry of 1:1. The Fe(III) protein complex is suggested to consist of an admixture of 6-coordinated His-bound high-spin and low-spin complexes. Marked pH-dependent spectral changes were observed, in contrast to the spectrum of the Fe(III) bound PAS-A domain of mPer2, which appeared pH-resistant. Treatment with diethylpyrocarbonate abolished the heme-binding ability of this protein, supporting the proposal that His is the axial ligand. Heme dissociation was composed of two phases with rate constants of 4.3 × 10⁻⁴ s⁻¹ (50%) and 4.0 × 10⁻³ s⁻¹ (50%), which were markedly higher than that (1.5 × 10⁻⁷ s⁻¹) of the prototype heme protein, myoglobin. The Soret CD band of the H454A PAS-B mutant was significantly different from those of wild-type and other His mutant proteins, strongly suggesting that His454 is one of the axial ligands for the Fe(III) complex. Copyright © 2010 Elsevier B.V. All rights reserved.

  10. 175 Years of Linear Programming

    Indian Academy of Sciences (India)

    The announcement, by L G Khachiyan, of the poly- nomial solvability of linear programming by the el- lipsoid method, followed by the probabilistic anal- yses of the simplex method in the early 1980's left researchers in linear programming with a dilemma. We had one method that was good in a theoreti- cal sense but poor in ...

  11. The Myths of Chinese Images Revisited: Persuasive Strategies in Hong Kong Anti-Drug Public Service Announcements.

    Science.gov (United States)

    Wong, Wendy Siuyi; Cuklanz, Lisa M.

    Hong Kong's Department of Information Services has been producing and systematically airing public service announcements (known as announcements in the public interest, or APIs) on a variety of selected themes such as cleaning up Hong Kong, road safety, crime, drugs, and health issues for over 20 years. The television announcements are shown every…

  12. CERN announces the fourth annual Beamline for Schools competition

    CERN Multimedia

    BL4S team

    2016-01-01

    CERN is pleased to announce the fourth annual Beamline for Schools (BL4S) competition. Once again, in 2017, a fully equipped beamline will be made available at CERN for students. As in previous years, two teams will be invited to the Laboratory to execute the experiments they proposed in their applications. The 2017 competition is being made possible thanks to support from the Alcoa Foundation for the second consecutive year.   The competition is open to teams of high-school students aged 16 or older who, if they win, are invited (with two supervisors) to CERN to carry out their experiment. Teams must have at least five students but there is no upper limit to a team’s size (although just nine students per winning team will be invited to CERN). Teams may be composed of pupils from a single school, or from a number of schools working together. As science-loving mega-celebrity Will.I.Am told us: “If you’re interested in science, technology, engineering or ...

  13. Family-friendly research and workplace initiative announced

    Science.gov (United States)

    Showstack, Randy

    2011-10-01

    A new U.S. National Science Foundation (NSF) initiative aims to increase the participation of women and girls in the fields of science, technology, engineering, and math (STEM) over the next 10 years by providing more flexible research policies, promoting flexible workplace options, and supporting STEM careers for women, Obama administration officials announced on 26 September. Currently, women earn about 41% of STEM doctoral degrees awarded by U.S. educational institutions but make up only about 28% of tenure-track faculty in U.S. colleges and universities, the officials said. "Unfortunately, too many young women drop out of promising careers in science, engineering, and math because of conflicts between their desire to start families and the need to rapidly ramp up their careers," said John Holdren, director of the White House Office of Science and Technology Policy (OSTP). "The way to help women stay in the STEM jobs pipeline is to create and support more flexible workplace policies that allow a women's career—or a man's, for that matter, but as we know, it's more common for women to give up STEM careers for family reasons—to thrive even as time is allowed for important family responsibilities."

  14. ONR D&I Electronics Technology Programs

    National Research Council Canada - National Science Library

    Moon, Jeong

    2008-01-01

    Program Status: One of the D&I program goals is to develop greatly improved field-plated MMW GaN HEMT devices with high ft/fmax, which will improve gain/PAE and output power of GaN HEMT MMIC PAs simultaneously...

  15. The Prenatal Care at School Program

    Science.gov (United States)

    Griswold, Carol H.; Nasso, Jacqueline T.; Swider, Susan; Ellison, Brenda R.; Griswold, Daniel L.; Brooks, Marilyn

    2013-01-01

    School absenteeism and poor compliance with prenatal appointments are concerns for pregnant teens. The Prenatal Care at School (PAS) program is a new model of prenatal care involving local health care providers and school personnel to reduce the need for students to leave school for prenatal care. The program combines prenatal care and education…

  16. Stigmatizing the other: An exploratory study of unintended consequences of eating disorder public service announcements.

    Science.gov (United States)

    Iles, Irina A; Atwell Seate, Anita; Waks, Leah

    2017-01-01

    This research explores the intended and unintended consequences of eating disorder public service announcements. We assessed participants' attitudes toward eating disorders and people with eating disorders, willingness to interact with people with eating disorders, and experience with eating disorders (covariate) at Time 1. At Time 2, participants were randomly assigned to watch a stigmatizing or a non-stigmatizing eating disorder public service announcement. Exposure to the stigmatizing public service announcement resulted in more negative attitudes toward eating disorders and in less willingness to interact with people with eating disorders, but not in significantly more negative attitudes toward people with eating disorders. The discussion highlights the practical implications for health communication campaigns.

  17. 75 FR 71141 - Announcement of National Geospatial Advisory Committee Meeting

    Science.gov (United States)

    2010-11-22

    ... established to advise the Federal Geographic Data Committee on management of Federal geospatial programs, the... --Geospatial Workforce --The National Map --FGDC Update --Geospatial Program Updates --NGAC Subcommittee... Geographic Data Committee. BILLING CODE 4311-AM-P ...

  18. Koptev announces space plans for Russia in 2003

    CERN Multimedia

    Pieson, D

    2003-01-01

    According to the head of the Russian Aviation and Space Agency, Yuri Koptev, the major emphasis of Russia's space program in 2003 will be supporting the nation's telecommunication satellite program (1/2 page).

  19. PAS: um perfil neoliberal de gestão de sistema público de saúde

    Directory of Open Access Journals (Sweden)

    Paulo Eduardo Elias

    1999-04-01

    Full Text Available NO PRESENTE artigo trata-se de analisar o Plano de Assistência à Saúde da Prefeitura do Município de São Paulo na perspectiva da gestão dos sistemas de saúde e da preservação dos direitos sociais. Apresenta-se uma breve retrospectiva da construção da saúde enquanto um direito social nas sociedades contemporâneas e traça-se o quadro das políticas de saúde no Brasil, em anos recentes, enfatizando seu processo de descentralização para a esfera municipal. Examina-se o PAS como alternativa de gestão e conclui-se pela incapacidade da sua regulação pelas forças de mercado e a sua inconsistência ideológica frente aos preceitos liberais para o setor saúde. Encerra-se com um breve balanço dos legados proporcionados por essa experiência de gestão.IN THIS ARTICLE is analysed the Health Care Plan (Plano de Assistencia à Saúde - PAS of the municipality of São Paulo from the perspective of the health system management and of preservation of social rights. It is presented a brief historical retrospective of the construction of health as a social right in contemporary societies, and a picture of health policies in Brazil in recent years emphasizing its decentralization process towards the municipal level. It is also examined the PAS as a management alternative and it is concluded that market forces are unable to regulate it and that it has ideological inconsistencies when faced to the liberal principles in force in the health sector. The author finishes the article with a brief balance of the legacy provided by this management experience.

  20. Differential response to anodal tDCS and PAS is indicative of impaired focal LTP-like plasticity in schizophrenia.

    Science.gov (United States)

    Strube, Wolfgang; Bunse, Tilmann; Nitsche, Michael A; Palm, Ulrich; Falkai, Peter; Hasan, Alkomiet

    2016-09-15

    Increasing evidence suggests that neural plasticity impairments, observed in schizophrenia patients, are driven by dysfunctional integration of neural signaling. However, what is less clear is whether this impairment is resultant from a general deficit in plastic induction or whether a specific plastic mechanism is affected. In the current study we aimed to assess whether schizophrenia has a selective impact on focal or non-focal plasticity induction. To pursue this goal we utilized two non-invasive stimulation techniques that differ in the mechanism of long-term potentiation (LTP)-like plasticity induction: focal paired associative stimulation (PAS) and non-focal anodal transcranial direct current stimulation (a-tDCS). 20 schizophrenia patients and 20 matched healthy controls received PAS and a-tDCS in two separate sessions. Cortical excitability and cortical plasticity were assessed by transcranial magnetic stimulation (TMS)-elicited motor evoked potentials (MEP). In both study groups, non-focal a-tDCS resulted in a significant increase of mean MEP magnitude indicating the successful induction of non-focal LTP-like plasticity. In contrast, an increase in mean MEP magnitude following PAS was only observed in the control group, suggesting impaired focal LTP-like plasticity in schizophrenia. Additionally, we observed significantly impaired short-latency intracortical inhibition (SICI) in schizophrenia. This is the first study to comparatively evaluate non-focal and focal plasticity mechanisms in schizophrenia patients. The differential patterns of LTP-like plasticity responses indicate that reduced plasticity in schizophrenia could be ascribed to impairments in spatially and temporally restricted signal integration. This impairment, coupled with an observed reduction of inhibitory circuit efficacy, might further contribute to impairments in coordinating focal signals. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. PAS-1, a protein affinity purified from Ascaris suum worms, maintains the ability to modulate the immune response to a bystander antigen.

    Science.gov (United States)

    Oshiro, Telma M; Enobe, Cristina S; Araújo, Cláudia A; Macedo, Mahasti S; Macedo-Soares, Maria Fernanda

    2006-04-01

    Helminth infections and parasite components have potent immunomodulatory effects on a host's immune system. In the present study, we investigated the effect of PAS-1, a protein component of Ascaris suum adult worms recognized by a monoclonal antibody (MAIP-1), on humoral and cell-mediated responses to a bystander antigen (ovalbumin [OVA]). MAIP-1 recognized only one of the three polypeptide chains of PAS-1, but neutralized the suppressive effect of the whole worm extract on OVA-specific antibody production. PAS-1 inhibited antibody production against a T-cell-dependent, but not a T-cell-independent, antigen in a dose-dependent way. IgM, IgG1, IgG2b, and also IgE and anaphylactic IgG1 levels were downregulated. In addition, PAS-1 inhibited OVA-specific delayed type hypersensitivity reactions in the footpad of mice, showing a potent immunosuppressive activity on both Th1 and Th2 responses that seems to be mediated by the induction of large amounts of IL-10 and IL-4. Indeed, PAS-1-specific spleen cells secreted sevenfold more IL-10 and threefold more IL-4 than OVA-specific cells in response to in vitro restimulation with the respective antigens. In conclusion, we showed that PAS-1, a single protein component from A. suum, maintains all its immunosuppressive properties.

  2. Modeling the uptake of neutral organic chemicals on XAD passive air samplers under variable temperatures, external wind speeds and ambient air concentrations (PAS-SIM).

    Science.gov (United States)

    Armitage, James M; Hayward, Stephen J; Wania, Frank

    2013-01-01

    The main objective of this study was to evaluate the performance and demonstrate the utility of a fugacity-based model of XAD passive air samplers (XAD-PAS) designed to simulate the uptake of neutral organic chemicals under variable temperatures, external wind speeds and ambient air concentrations. The model (PAS-SIM) simulates the transport of the chemical across the air-side boundary layer and within the sampler medium, which is segmented into a user-defined number of thin layers. Model performance was evaluated using data for polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) from a field calibration study (i.e., active and XAD-PAS data) conducted in Egbert, Ontario, Canada. With some exceptions, modeled PAS uptake curves are in good agreement with the empirical PAS data. The results are highly encouraging, given the uncertainty in the active air sampler data used as input and other uncertainties related to model parametrization (e.g., sampler-air partition coefficients, the influence of wind speed on sampling rates). The study supports the further development and evaluation of the PAS-SIM model as a diagnostic (e.g., to aid interpretation of calibration studies and monitoring data) and prognostic (e.g., to inform design of future passive air sampling campaigns) tool.

  3. The PAS domains of the major sporulation kinase in Bacillus subtilis play a role in tetramer formation that is essential for the autokinase activity.

    Science.gov (United States)

    Kiehler, Brittany; Haggett, Lindsey; Fujita, Masaya

    2017-08-01

    Sporulation in Bacillus subtilis is induced upon starvation. In a widely accepted model, an N-terminal "sensor" domain of the major sporulation kinase KinA recognizes a hypothetical starvation signal(s) and autophosphorylates a histidine residue to activate the master regulator Spo0A via a multicomponent phosphorelay. However, to date no confirmed signal has been found. Here, we demonstrated that PAS-A, the most N-terminal of the three PAS domains (PAS-ABC), is dispensable for the activity, contrary to a previous report. Our data indicated that the autokinase activity is dependent on the formation of a functional tetramer, which is mediated by, at least, PAS-B and PAS-C. Additionally, we ruled out the previously proposed notion that NAD(+) /NADH ratio controls KinA activity through the PAS-A domain by demonstrating that the cofactors show no effects on the kinase activity in vitro. In support of these data, we found that the cofactors exist in approximately 1000-fold excess of KinA in the cell and the cofactors' ratio does not change significantly during growth and sporulation, suggesting that changes in the cofactor ratio might not play a role in controlling KinA activity. These data may refute the widely-held belief that the activity of KinA is regulated in response to an unknown starvation signal(s). © 2017 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

  4. 78 FR 53149 - Medicare and Medicaid Programs: Continued Approval of American Osteopathic Association/Healthcare...

    Science.gov (United States)

    2013-08-28

    ... Approval of American Osteopathic Association/Healthcare Facilities Accreditation Program (AOA/HFAP's.... SUMMARY: This final notice announces our decision to approve American Osteopathic Association/Healthcare... determined by CMS. The American Osteopathic Association/Healthcare Facilities Accreditation Program's (AOA...

  5. 78 FR 28224 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2013-05-14

    ... Requirements AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing that a collection of information entitled ``Prescription Drug Product Labeling... collection of information entitled ``Prescription Drug Product Labeling; Medication Guide Requirements'' to...

  6. 75 FR 26780 - Request for Comment: National Center for Complementary and Alternative Medicine Announcement of...

    Science.gov (United States)

    2010-05-12

    ... Comment: National Center for Complementary and Alternative Medicine Announcement of Strategic Planning White Papers ACTION: Notice. SUMMARY: The National Center for Complementary and Alternative Medicine... for Complementary and Alternative Medicine (NCCAM) was established in 1998 with the mission of...

  7. 78 FR 25079 - Forum on Environmental Measurements Announcement of Competency Policy for Assistance Agreements

    Science.gov (United States)

    2013-04-29

    ... AGENCY Forum on Environmental Measurements Announcement of Competency Policy for Assistance Agreements... Agreements. SUMMARY: The Environmental Protection Agency's Forum on Environmental Measurements (FEM) is... and Technology Policy Council) established the Forum on Environmental Measurements (FEM) as a standing...

  8. 78 FR 76841 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2013-12-19

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Announcement of Office of Management and Budget Approval; Guidance for Industry on Hypertension Indication: Drug Labeling for Cardiovascular Outcome Claims AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY...

  9. 76 FR 37123 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2011-06-24

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Announcement of Office of Management and Budget Approval; Guidance for Industry on Pharmacogenomic Data Submissions AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA...

  10. 78 FR 38361 - Announcement of Funding Awards for the Rural Capacity Building for Community Development and...

    Science.gov (United States)

    2013-06-26

    ... URBAN DEVELOPMENT Announcement of Funding Awards for the Rural Capacity Building for Community... organizations with expertise in rural housing and community development to enhance the capacity and ability of local governments, Indian tribes, housing development organizations, rural community development...

  11. 76 FR 9022 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2011-02-16

    ... Office of Management and Budget Approval; Format and Content Requirements for Over-the-Counter Drug... Administration (FDA) is announcing that a collection of information entitled ``Format and Content Requirements...

  12. EPA announces additional groundwater investigation at Delaware City PVC Superfund site

    Science.gov (United States)

    PHILADELPHIA (Oct. 15, 2015) - The U.S. Environmental Protection Agency today announced a new investigation to determine the nature and extent of groundwater contamination at the Delaware City PVC Superfund site in New Castle County.

  13. Annual Earnings Announcements and Market Reaction: The Influence of Screening Criteria for Thin Trading

    DEFF Research Database (Denmark)

    Møller, Peder Fredslund; Thinggaard, Frank; Lønroth, Helle L.

    2001-01-01

    This paper presents the findings of an event study of the Danish stock market price reactions to annual earnings announcements in the period 1993-1997, with a dual purpose. The primary purpose is to find out how market reactions vary with different screening criteria for thin trading. Our findings...... on this point suggest that the Danish stock market, although small, seems to have different segments of shares in relation to earnings announcements. Applying different screening criteria we find differences both in terms of how quickly the market reacts to earnings announcements and the relative quality...... purpose of our study is briefly to compare our findings with those of a similar study for the period 1971-1981. The aim is to find indications of developments in the Danish market's reactions to earnings announcements since that study. We find distinct indications that the Danish stock market in some...

  14. Public Service Announcement: Heart Disease Doesn't Care What You Wear

    Science.gov (United States)

    ... Home Current Issue Past Issues Public Service Announcement Heart Disease Doesn't Care What You Wear Past Issues / ... version of this page please turn Javascript on. Heart Disease Doesn't Care What You Wear IT'S THE # ...

  15. Influence of the Angelina Jolie Announcement and Insurance Reimbursement on Practice Patterns for Hereditary Breast Cancer.

    Science.gov (United States)

    Lee, Jihyoun; Kim, Sungwon; Kang, Eunyoung; Park, Suyeon; Kim, Zisun; Lee, Min Hyuk

    2017-06-01

    Lack of awareness, the stigma of carrying a genetic mutation, and economic factors are barriers to acceptance of BRCA genetic testing or appropriate risk management. We aimed to investigate the influence of Angelina Jolie's announcement of her medical experience and also health insurance reimbursement for BRCA gene testing on practice patterns for hereditary breast and ovarian cancer (HBOC). A survey regarding changes in practice patterns for HBOC before and after the announcement was conducted online. The rate of BRCA gene testing was obtained from the National Health Insurance Review and Assessment Service database. From May to August 2016, 70 physicians responded to the survey. Genetic testing recommendations and prophylactic management were increased after the announcement. Risk-reducing salpingo-oophorectomy and contralateral prophylactic mastectomy was significantly increased in BRCA carriers with breast cancer. The BRCA testing rate increased annually. Health insurance and a celebrity announcement were associated with increased genetic testing.

  16. 78 FR 38074 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in...

    Science.gov (United States)

    2013-06-25

    ... DEPARTMENT OF LABOR Employment and Training Administration Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in Alabama, Alaska, Delaware, Illinois, Louisiana, Michigan, Mississippi, Ohio, the Virgin Islands and Wisconsin in the Emergency Unemployment Compensation...

  17. Nearby supernova factory announces 34 supernovae in one year'; best Rookie year ever for supernova search

    CERN Document Server

    2003-01-01

    The Nearby Supernova Factory (SNfactory), an international collaboration based at Lawrence Berkeley National Laboratory, announced that it had discovered 34 supernovae during the first year of the prototype system's operation (2 pages).

  18. 77 FR 23732 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2012-04-20

    ... Office of Management and Budget Approval; Current Good Manufacturing Practices and Related Regulations...) is announcing that a collection of information entitled ``Current Good Manufacturing Practices and... collection of information entitled ``Current Good Manufacturing Practices and Related Regulations for Blood...

  19. 76 FR 50481 - Announcement of Requirements and Registration for “Lifeline Facebook App Challenge”; Correction

    Science.gov (United States)

    2011-08-15

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for ``Lifeline Facebook App Challenge... Facebook App Challenge''. DATES: This correction is effective August 15, 2011. FOR FURTHER INFORMATION...

  20. 76 FR 41265 - Agency Information Collection Activities; Announcement of Office of Management and Budget...

    Science.gov (United States)

    2011-07-13

    ... HUMAN SERVICES Food and Drug Administration Agency Information Collection Activities; Announcement of Office of Management and Budget Approval; Restaurant Menu and Vending Machine Labeling: Recordkeeping and... 2010 AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug...

  1. 75 FR 2863 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-01-19

    ... global market statistics. The Federal Reserve System and other government agencies use the survey to... From the Federal Register Online via the Government Publishing Office FEDERAL RESERVE SYSTEM Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and...

  2. An Operational Event Announcer for the LHC Control Centre Using Speech Synthesis

    CERN Document Server

    Page, S

    2011-01-01

    The LHC Island of the CERN Control Centre is a busy working environment with many status displays and running software applications. An audible event announcer was developed in order to provide a simple and efficient method to notify the operations team of events occurring within the many subsystems of the accelerator. The LHC Announcer uses speech synthesis to report messages based upon data received from multiple sources. General accelerator information such as injections, beam energies and beam dumps are derived from data received from the LHC Timing System. Additionally, a software interface is provided that allows other surveillance processes to send messages to the Announcer using the standard control system middleware. Events are divided into categories which the user can enable or disable depending upon their interest. Use of the LHC Announcer is not limited to the Control Centre and is intended to be available to a wide audience, both inside and outside CERN. To accommodate this, it...

  3. Influence of the Angelina Jolie Announcement and Insurance Reimbursement on Practice Patterns for Hereditary Breast Cancer

    OpenAIRE

    Lee, Jihyoun; Kim, Sungwon; Kang, Eunyoung; Park, Suyeon; Kim, Zisun; Lee, Min Hyuk

    2017-01-01

    Lack of awareness, the stigma of carrying a genetic mutation, and economic factors are barriers to acceptance of BRCA genetic testing or appropriate risk management. We aimed to investigate the influence of Angelina Jolie's announcement of her medical experience and also health insurance reimbursement for BRCA gene testing on practice patterns for hereditary breast and ovarian cancer (HBOC). A survey regarding changes in practice patterns for HBOC before and after the announcement was conduct...

  4. Trading in Target Stocks Before Takeover Announcements: An Analysis of Stock and Option Markets

    OpenAIRE

    Marcus Clements; Harminder Singh; Antonie Van Eekelen

    2007-01-01

    In this study we examine both informed trading and contraire trading preceding takeover announcements on US target firms. Our findings suggest that both informed trading and contraire trading exists within the period preceding takeover announcements on both the stock and option markets as evident through abnormal returns and trading volumes. In regard to contraire trading, this study investigates possible explanations for its existence including liquidity clustering, falsely informed trading ...

  5. Study on Emergency Announcement Systems to Reduce Damages by Hazardous Disasters in Coastal Fishery Communities

    Science.gov (United States)

    Gotoh, Hiroshi

    Recently, a number of hazardous disasters occurred everywhere in the world. In Japan, though the administrative sections have performed to construct structures for measures to protect people by hazards, it is important that the people evacuate in the event of disasters adequately. In this study, some questionnaires and field investigations were carried out on the effectiveness of emergency announcement systems installed in coastal fishery communities facing Pacific Ocean. Also, some ways to improve emergency announcement systems are discussed.

  6. FY 2017 Hazardous Waste Management Grant Program for Tribes

    Science.gov (United States)

    This notice announces the availability of funds and solicits proposals from federally-recognized tribes or intertribal consortia for the development and implementation of hazardous waste programs and for building capacity to address hazardous waste

  7. Mixtures Equation Pilot Program to Reduce Animal Testing

    Science.gov (United States)

    EPA is announcing the start of a pilot program to evaluate the usefulness and acceptability of a mathematical tool (the GHS Mixtures Equation), which is used in the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

  8. Oral Cancer Exam

    Medline Plus

    Full Text Available ... Gland Tumors More Science News Grants & Funding Funding Opportunity Announcements By Topic RFAs PAs Application Forms and ... Dental and Medical Students See All Careers & Training Opportunities Job Openings Loan Repayment Programs Careers in Dental ...

  9. Identifying Galactic halo PN candidates in the imaging surveys: J-PLUS/S-PLUS and J-PAS

    Science.gov (United States)

    Gutiérrez-Soto, L.; Gonçalves, D. R.; Akras, S.; Cortesi, A.; Ederoclite, T.; Aparício-Villegas, T.; Borges-Fernandes, M.; Daflon, S.; Pereira, C. B.; Mendes de Oliveira, C.; Viironen, K.; J-PAS Collaboration

    2017-07-01

    Halo planetary nebulae (HPNe) are able to reveal important information about stellar and chemical evolution in galaxies. Their characteristic low continuum and strong emission lines make them good objects to be searched by multi-filter imaging surveys. Given that only 14 HPNe are known in the Galaxy, we are exploring colour-colour diagrams to search for these sources in Javalambre/Southern Photometric Local Universe Survey (J-PLUS/S-PLUS) and the Javalambre-Physics of the Accelerating Universe Astrophysical Survey (J-PAS). They are narrow- and broad-band imaging cosmological surveys, with 12 and 54 filters, respectively. The J-PAS survey will be able to observe 85002 of Northern sky, it will detect sources up to magnitude mAB˜23. In the case of the J-PLUS survey the limit magnitudes is around mAB˜21.5. The S-PLUS survey will observe more than 60002 and it will map the Southern sky. Other optical emission lines sources, such as Galactic and extragalactic symbiotic stars (SySts), cataclysmic variables (CVs), QSOs at different redshifts, star-forming galaxies (SFGs), extragalactic H II regions and supernova remnants (SNR) can mimic PNe. Therefore, we explore different colour-colour diagrams in order to highlight those that can better identify HPN candidates, separating them from these other objects.

  10. Periodic acid-Schiff (PAS) reaction and plastination in whole body slices. A novel technique to identify fascial tissue structures.

    Science.gov (United States)

    Steinke, Hanno; Wiersbicki, Dina; Speckert, Marie-Lynn; Merkwitz, Claudia; Wolfskämpf, Thomas; Wolf, Benjamin

    2017-11-13

    Since collagen rich fascial tissue is often very delicate and difficult to discern on native tissue slices, we have developed a method for staining full-body slices using the periodic acid-Schiff (PAS) reaction with subsequent plastination. Since the PAS reaction primarily stains carbohydrates, we could exploit the circumstance that different collagen types vary in carbohydrate content. Contrary to fasciae, tissues such as muscle, bone, nerves and blood vessels exhibit significantly less staining or remain unstained. We have validated the whole-body slice staining results in microscopic tissue slides which were stained with standard extracellular matrix stains such as Masson-Goldner trichrome stain and van-Gieson stain. Furthermore, we have performed immunofluorescence imaging to confirm the presence of collagen in the stained tissue. We achieved very good staining and plastination results and were able to clearly identify even very thin fascia in transversal body slices. This technique may prove useful in advancing our knowledge on the complex topography of fascial structures. Copyright © 2017 Elsevier GmbH. All rights reserved.

  11. The Cova des Pas de Vallgornera (Llucmajor, Mallorca: a singular deposit bearing an exceptional well preserved Early Pleistocene vertebrate fauna

    Directory of Open Access Journals (Sweden)

    Pere Bover

    2014-05-01

    Full Text Available The Cova des Pas de Vallgornera is the longest cave of Mallorca (Balearic Islands, Western Mediterranean and one of the 30 longest caves in the world. The exploration of one of the galleries allowed the discovery of a fossiliferous deposit of vertebrate remains in a remarkable preservation state. The fossil faunal complex found in this gallery is composed of up to 5 mammalian species (Myotragus aff. kopperi, Hypnomys onicensis, Nesiotites aff. ponsi, Rhinolophus aff. mehelyi and Pipistrellus sp., at least 14 bird species (among them two Mallorcan endemic taxa: Pica mourerae and Athene vallgornerensis, one reptile (Podarcis aff. lilfordi and one amphibian (Discoglossus sp.. This faunal composition is similar to the one recorded in the Pedrera de s’Ònix, a well known deposit from the Early Pleistocene of Mallorca, and shared morphological characteristics between taxa of both deposits suggest that the chronology of the Cova des Pas de Vallgornera should be considered Early Pleistocene as well. Both taxonomical analysis and chronology of this fauna furnished information on some speleological aspects of the cave.

  12. Anxiety in early Parkinson's disease: Validation of the Italian observer-rated version of the Parkinson Anxiety Scale (OR-PAS).

    Science.gov (United States)

    Santangelo, Gabriella; Falco, Fabrizia; D'Iorio, Alfonsina; Cuoco, Sofia; Raimo, Simona; Amboni, Marianna; Pellecchia, Maria Teresa; Longo, Katia; Vitale, Carmine; Barone, Paolo

    2016-08-15

    Anxiety disorders are common in Parkinson's Disease (PD) and their identification is relevant even at early stages. The Parkinson Anxiety Scale (PAS) evaluates anxiety in PD; it was used only in the original validation study in PD patients mainly at 2-3 stages of Hoehn & Yahr system (H&Y). The study aimed to investigate psychometric properties of observer-rated version of the PAS (OR-PAS), prevalence rate of anxiety and its features, compared with diagnostic criteria in early PD patients. A sample of 101 PD patients with H&Y:1-2 underwent the OR-PAS. To assess convergent and divergent validity, PD patients underwent Beck Anxiety Inventory, and scales assessing depression, apathy, anhedonia and cognition. To diagnose anxiety disorders, Mini International Neuropsychiatric Inventory was used as gold standard. A "receiver operating characteristics" curve was obtained; positive and negative predictive values were calculated for different cut-off points of the OR-PAS and its subscales. There was no missing data, no floor and ceiling effects; mean score was 12.2±10.1; Cronbach's alpha was 0.899. The OR-PAS showed good convergent and divergent validity. Maximum discrimination was obtained with a cut-off score of 8.5. The anxiety occurred in 59 patients (58.4%). The OR-PAS is a reliable and valid screening instrument for assessing anxiety in patients at early PD. Anxiety was found in 58.4% of PD patients, demonstrating that anxiety occurs even at early stages. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. A comprehensive protein-protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1.

    Science.gov (United States)

    DeMille, Desiree; Bikman, Benjamin T; Mathis, Andrew D; Prince, John T; Mackay, Jordan T; Sowa, Steven W; Hall, Tacie D; Grose, Julianne H

    2014-07-15

    Per-Arnt-Sim (PAS) kinase is a sensory protein kinase required for glucose homeostasis in yeast, mice, and humans, yet little is known about the molecular mechanisms of its function. Using both yeast two-hybrid and copurification approaches, we identified the protein-protein interactome for yeast PAS kinase 1 (Psk1), revealing 93 novel putative protein binding partners. Several of the Psk1 binding partners expand the role of PAS kinase in glucose homeostasis, including new pathways involved in mitochondrial metabolism. In addition, the interactome suggests novel roles for PAS kinase in cell growth (gene/protein expression, replication/cell division, and protein modification and degradation), vacuole function, and stress tolerance. In vitro kinase studies using a subset of 25 of these binding partners identified Mot3, Zds1, Utr1, and Cbf1 as substrates. Further evidence is provided for the in vivo phosphorylation of Cbf1 at T211/T212 and for the subsequent inhibition of respiration. This respiratory role of PAS kinase is consistent with the reported hypermetabolism of PAS kinase-deficient mice, identifying a possible molecular mechanism and solidifying the evolutionary importance of PAS kinase in the regulation of glucose homeostasis. © 2014 DeMille et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  14. CreditCoin: A Privacy-Preserving Blockchain-Based Incentive Announcement Network for Communications of Smart Vehicles

    KAUST Repository

    Li, Lun

    2018-01-23

    The vehicular announcement network is one of the most promising utilities in the communications of smart vehicles and in the smart transportation systems. In general, there are two major issues in building an effective vehicular announcement network. First, it is difficult to forward reliable announcements without revealing users\\' identities. Second, users usually lack the motivation to forward announcements. In this paper, we endeavor to resolve these two issues through proposing an effective announcement network called CreditCoin, a novel privacy-preserving incentive announcement network based on Blockchain via an efficient anonymous vehicular announcement aggregation protocol. On the one hand, CreditCoin allows nondeterministic different signers (i.e., users) to generate the signatures and to send announcements anonymously in the nonfully trusted environment. On the other hand, with Blockchain, CreditCoin motivates users with incentives to share traffic information. In addition, transactions and account information in CreditCoin are tamper-resistant. CreditCoin also achieves conditional privacy since Trace manager in CreditCoin traces malicious users\\' identities in anonymous announcements with related transactions. CreditCoin thus is able to motivate users to forward announcements anonymously and reliably. Extensive experimental results show that CreditCoin is efficient and practical in simulations of smart transportation.

  15. Announcement: Release of National Association of State Public Health Veterinarians' 2016 Compendium of Animal Rabies Prevention and Control.

    Science.gov (United States)

    2017-02-10

    The 2016 Compendium of Animal Rabies Prevention and Control was released in the March 1, 2016 issue of the Journal of the American Veterinary Medical Association (1). The Compendium's national recommendations for the prevention and control of animal rabies are intended to serve as a basis for an effective rabies control program in the United States. These recommendations facilitate standardization of control procedures across jurisdictions and are reviewed annually and updated as necessary. This announcement of the recommendations facilitates their adoption by increasing awareness among public health agencies and practitioners and makes more readily available a link to statutes and regulations in certain jurisdictions that refer directly to the Compendium language published in MMWR.

  16. L'emploi alternative de certains signes, à la languen'est pas absolumais con­ditionné

    Directory of Open Access Journals (Sweden)

    Mihailo Stevanović

    1972-12-01

    Full Text Available L'aoriste et le présent des verbes perfectifs, par exemple, ne sont des oppositions syntaxiques que dans la narration et non, comme on le pensait, dans chaque emploi temporal relatif. Dans les exemples du type: Lujo ogrnū haljinicu, pa se spusti na travui leže -l'aoriste pourrait être substitué par le présent, et dans l'exemple suivant: Uveče ga brat njegov Milutin uzmē te ga iznesē I sàhrani kod crkve- le present pourrait être suhstitué par l'aoriste sans que le sensde ces phrases soit nullement changé. Pourtant dans les cas comme: Mi jedanput Šćepana zàcarismo et Razbolje se Vojvoda Dojčine u Solunu gradu bijelome, le présent ne pourrait pas être employé en fonction de l'aoriste temporel relatif parce que dans le premier exemple il ne s'agit pas de narration et dans le second, malgré le caractère narratif du vers, le présent ne pourrait pas signifier sans ambiguité l'accomplissement en une seule fois de l'action, mais il aurait suggeré sa répétition- significationque l'aoristen'a pas. Le deuxième cas de l'emploi frequent des formes verhales en tautqu'oppositions syntaxiques en serbo-croateest représenté parla function que le présent perfectif et le futur II ont d'exprimer des actions quin'ont pas encore été réalisées ou dont la realization n'est pas certaine. Mais l'emploi alternatif n'est pas absolu ici non plus: il est limité par l'impossibilité du present d'exprimer un accomplissement antérieur à une realization hypothétique de l'action, tandis que le future II, à côté de ce qu'il a en commun avec le présent, il a cette signification aussi (Čim stignemo do vase kuće, odmah ćemo produžiti, ako drugi  budu došli. On cite les constructions avec les prépositions prema et k(a+ datif comme un cas qui montre que l'emploi alternatif est limité. A savoir, ces deux constructions représentent les oppositions syntaxiques au cas où le verbe principal exprime le mouvement en direction du nom employ

  17. Pas de Vallgornera Cave, Majorca (Spain): one the largest littoral caves in Europe; La cueva des Pas de Vallgornera, Mallorca (Espana): unas de las cuevas litorales mas grandes de Europa

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, B.; Mulet, T.; Rodriguez-Homar, M.; Merino, A.

    2016-07-01

    The Pas de Vallgornera cave is the longest cave in the Balearic Islands and one of the largest in Europe (more than 73 km long). It is found on the Miocene reef of Llucmajor Platform and its genesis is related to the development of normal faults and associated fracture systems with N 180° S and N 60° E orientation that took place during the Neogene. It is noteworthy for the abundance, variety and beauty of the speleothems, paleontological richness and to present evidence of hypogene basal recharge. Due to its singularity, it has served as the basis of several scientific studies on groundwater level fluctuations during the quaternary period and others related to the existence of one of most important paleontological sites in Mallorca as far as vertebrates are concerned. (Author)

  18. The dominant 55 kDa allergen of the subtropical Bahia grass (Paspalum notatum) pollen is a group 13 pollen allergen, Pas n 13.

    Science.gov (United States)

    Davies, Janet M; Voskamp, Astrid; Dang, Thanh D; Pettit, Benjamin; Loo, Dorothy; Petersen, Arnd; Hill, Michelle M; Upham, John W; Rolland, Jennifer M; O'Hehir, Robyn E

    2011-03-01

    Bahia grass, Paspalum notatum, is an important pollen allergen source with a long season of pollination and wide distribution in subtropical and temperate regions. We aimed to characterize the 55 kDa allergen of Bahia grass pollen (BaGP) and ascertain its clinical importance. BaGP extract was separated by 2D-PAGE and immunoblotted with serum IgE of a grass pollen-allergic patient. The amino-terminal protein sequence of the predominant allergen isoform at 55 kDa had similarity with the group 13 allergens of Timothy grass and maize pollen, Phl p 13 and Zea m 13. Four sequences obtained by rapid amplification of the allergen cDNA ends represented multiple isoforms of Pas n 13. The predicted full length cDNA for Pas n 13 encoded a 423 amino acid glycoprotein including a signal peptide of 28 residues and with a predicted pI of 7.0. Tandem mass spectrometry of tryptic peptides of 2D gel spots identified peptides specific to the deduced amino acid sequence for each of the four Pas n 13 cDNA, representing 47% of the predicted mature protein sequence of Pas n 13. There was 80.6% and 72.6% amino acid identity with Zea m 13 and Phl p 13, respectively. Reactivity with a Phl p 13-specific monoclonal antibody AF6 supported designation of this allergen as Pas n 13. The allergen was purified from BaGP extract by ammonium sulphate precipitation, hydrophobic interaction and size exclusion chromatography. Purified Pas n 13 reacted with serum IgE of 34 of 71 (48%) grass pollen-allergic patients and specifically inhibited IgE reactivity with the 55 kDa band of BaGP for two grass pollen-allergic donors. Four isoforms of Pas n 13 from pI 6.3-7.8 had IgE-reactivity with grass pollen allergic sera. The allergenic activity of purified Pas n 13 was demonstrated by activation of basophils from whole blood of three grass pollen-allergic donors tested but not control donors. Pas n 13 is thus a clinically relevant pollen allergen of the subtropical Bahia grass likely to be important in eliciting

  19. Geodynamic laboratory SRC PAS in Książ - state of 2013

    Directory of Open Access Journals (Sweden)

    Damian Kasza

    2014-07-01

    Full Text Available The paper provides information on the history of the creation and activities of the Geodynamic Laboratory in Książ (Central Sudetes, SW Poland. A unique laboratory environment, instrumental facilities and research program were presented. Particular attention was paid to the study of geodynamic signals of non-tidal nature, relating to the local geological and tectonic situation. Tectonic research is examined in terms of both cognitive (identification of causes of the occurrence and scale of the problem, as well as utilitarian aspect designed to assess the impact of recorded effects on the earth's surface and architectural objects.

  20. Crystal structures of the F and pSLT plasmid TraJ N-terminal regions reveal similar homodimeric PAS folds with functional interchangeability.

    Science.gov (United States)

    Lu, Jun; Wu, Ruiying; Adkins, Joshua N; Joachimiak, Andrzej; Glover, J N Mark

    2014-09-16

    In the F family of conjugative plasmids, TraJ is an essential transcriptional activator of the tra operon that encodes most of the proteins required for conjugation. Here we report for the first time the X-ray crystal structures of the TraJ N-terminal domains from the prototypic F plasmid (TraJF(11-130)) and from the Salmonella virulence plasmid pSLT (TraJpSLT(1-128)). Both structures contain similar Per-ARNT-Sim (PAS) folds, which further homodimerize through the N-terminal helix and the structurally conserved β-sheet of the PAS fold from each protomer. Mutational analysis reveals that the observed dimeric interface is critical for TraJF transcriptional activation, indicating that dimerization of TraJ is required for its in vivo function. TraJ is specific in activating its cognate tra operon promoter; however, heterologous PAS domains from pSLT and R100 TraJ can functionally replace the TraJF PAS domain, suggesting that the allelic specificity of TraJ is solely mediated by the region C-terminal to the PAS domain.

  1. Prison needle exchange programs work.

    Science.gov (United States)

    2004-12-01

    On 27 October 2004 the Canadian HIV/AIDS Legal Network and the Ontario Medical Association (OMA) released reports recommending that needle exchange programs (NEPs) be implemented in prisons, based on evidence that such programs promote and protect the health of both prisoners and prison staff. At the same time, the Scottish Prison Service announced that it was looking at providing such programs, and an Iranian physician reported on a pilot project in his country.

  2. 76 FR 28449 - Announcement of National Geospatial Advisory Committee Meeting

    Science.gov (United States)

    2011-05-17

    ... advise the Federal Geographic Data Committee on management of Federal geospatial programs, the.... --Transportation for the Nation. --Census Update. --Parcel Data. --National Map Users Conference. --NGAC Action..., Federal Geographic Data Committee. BILLING CODE 4311-AM-P ...

  3. Exhibition of the winning pictures from CERN Photowalk 2015 | 4 - 14 April | “Pas Perdus” area

    CERN Multimedia

    2016-01-01

    Twenty photos entered into the “CERN Photowalk 2015: Behind the scenes at the Laboratory” competition will be on display in the “Pas Perdus” area (Buildings 500 and 61) from 4 to 14 April.    The ISOLDE installation as seen by Andrew Hara, one of the photographers who took part in the CERN Photowalk 2015 competition. In September 2015, 19 photographers from all over the world visited CERN, cameras at the ready, to find out what goes on behind the scenes at the Laboratory. They had the opportunity to take photographs of daily life on the CERN site and of facilities including the Linac 4 linear accelerator, the main workshop and ISOLDE. A jury selected the best photos taken at CERN and the top three were entered into the world's biggest physics photography competition, the Global Physics Photowalk, in which eight laboratories participated. The winners of the Global Physics Photowalk can be seen here.

  4. L’église Notre-Dame de Rocquigny (Pas-de-Calais : restauration, reconstruction ou abandon ?

    Directory of Open Access Journals (Sweden)

    Jacques Philippon

    2009-11-01

    Full Text Available IntroductionLe village de Rocquigny (274 habitants est situé au sud du département du Pas-de-Calais (canton de Bapaume, à proximité immédiate d’une des importantes lignes de front de la Grande Guerre : la ligne Hindenburg. Ce qui explique que la quasi-totalité des villages de ce territoire ont été totalement détruits notamment lors des grandes offensives de 1917.C’est ainsi que le village s’est retrouvé au cœur du vaste dispositif de la Reconstruction mis en œuvre dans les années 1920 par l...

  5. Viveret Patrick, 2005, Pourquoi ça ne va pas plus mal?, Fayard, 264 p.

    Directory of Open Access Journals (Sweden)

    Fabien Thurette

    2008-05-01

    Full Text Available Patrick Viveret est philosophe de formation et Conseiller-maître à la Cour des comptes. Il a, en outre, été chargé d’une mission, confiée par l'éphémère Secrétaire d'État à l'économie solidaire Guy Hascoët, puis prolongée par le Président Chirac sur une « autre approche de la richesse », dont le rapport final a été publié sous le titre Reconsidérer la richesse (2004.Dans son essai Pourquoi ça ne va pas plus mal ? publié en 2005, Patrick Viveret nous livre une analyse philosophique sur le « m...

  6. Joutes, emprises et pas d'armes en Castille, Bourgogne et France 1428 – 1470

    Directory of Open Access Journals (Sweden)

    Sébastien Nadot

    2010-05-01

    Full Text Available Date de soutenance : 28 avril 2009Composition du JuryAdeline Rucquoi (Directeur de recherches au CNRS,Françoise Michaud – Frejaville (Professeur émérite, Université d'Orléans, Philippe Contamine (Membre de l'Institut, Denis Menjot (Professeur, Université Lyon 2, Jacques Paviot (Professeur, Université Paris 12, Michel Wieviorka (Directeur d'études, ÉHESS.RésuméLes historiens du sport considèrent qu'il n'y a pas de filiation directe entre les pratiques physiques médiévales et le sport mod...

  7. Psihoemocionālais stress un darba vides riski farmaceitu darbā. Preventijas pasākumi

    OpenAIRE

    Mļečko, Ilona

    2015-01-01

    Maģistra darbā izvērtēti psihoemocionālie un citi darba vides riski farmaceitu darbā, pielietojot mūsdienīgas metodes. Izstrādāti preventīvie pasākumi. Pētījums tika veikts Latvijas aptiekās. Darbs sastāv no trijām daļām – literatūras analīzes, pētnieciskās daļas, rezultātiem un diskusijas. Literatūras analīze liecina, ka farmaceiti ikdienas darbā pakļauti daudzveidīgiem darba vides riskiem. Apkopojot risku novērtēšanas rezultātus, secināts, ka būtiskākais darba vides risks farmaceiti...

  8. An Event Study: Efficient or Not? Share Prices' Reactions to Dividend Announcements in Hong Kong Stock Market

    OpenAIRE

    Leng, Xinyu

    2008-01-01

    This dissertation is an event study in the area of Efficient Market Hypothesis (EMH), it focuses on exploring the impact of dividend announcements on share prices' movements in Hong Kong stock market. A sample of 43 companies containing 185 announcements within the recent 5 years is selected and t-test is employed as means to test the statistical significance of abnormal returns around the announcement dates. The result of this study suggests that the Hong Kong stock market is inefficient wit...

  9. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

    Science.gov (United States)

    Wu, Dalei; Su, Xiaoyu; Potluri, Nalini; Kim, Youngchang; Rastinejad, Fraydoon

    2016-10-26

    The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum disorders and bipolar disease. NPAS1 and NPAS3 must each heterodimerize with the aryl hydrocarbon receptor nuclear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene regulation. Here we examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. Through expanded architectural comparisons between these complexes and HIF-1α-ARNT, HIF-2α-ARNT and CLOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presents as an ideal class of transcription factors for direct targeting by small-molecule drugs.

  10. H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.

    Directory of Open Access Journals (Sweden)

    Ricardo B Valladares

    2015-07-01

    Full Text Available Host and commensals crosstalk, mediated by reactive oxygen species (ROS, has triggered a growing scientific interest to understand the mechanisms governing such interaction. However, the majority of the scientific studies published do not evaluate the ROS production by commensals bacteria. In this context we recently showed that Lactobacillus johnsonii N6.2, a strain of probiotic value, modulates the activity of the critical enzymes 2,3-indoleamine dioxygenase via H2O2 production. L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences. Understanding the mechanisms of H2O2 production is critical to predict the probiotic value of these strains and to optimize bacterial biomass production in industrial processes. We performed a transcriptome analysis to identify genes differentially expressed in L. johnsonii N6.2 cells collected from cultures grown under different aeration conditions. Herein we described the biochemical characteristics of a heterodimeric FMN reductase (FRedA/B whose in vitro activity is controlled by LjPAS protein with a typical Per-Arnst-Sim (PAS sensor domain. Interestingly, LjPAS is fused to the FMN reductase domains in other lactobacillaceae. In L. johnsonii, LjPAS is encoded by an independent gene which expression is repressed under anaerobic conditions (>3 fold. Purified LjPAS was able to slow down the FRedA/B initial activity rate when the holoenzyme precursors (FredA, FredB and FMN were mixed in vitro. Altogether the results obtained suggest that LjPAS module regulates the H2O2 production helping the cells to minimize oxidative stress in response to environmental conditions.

  11. In vitro variables of apheresis platelets are stably maintained for 7 days with 5% residual plasma in a glucose and bicarbonate salt solution, PAS-5.

    Science.gov (United States)

    Radwanski, Katherine; Wagner, Stephen J; Skripchenko, Andrey; Min, Kyungyoon

    2012-01-01

    Platelet additive solutions (PASs) facilitate improved recovery of plasma and may reduce the severity and/or frequency of plasma-associated transfusion reactions. Current apheresis platelet (PLT) PAS products contain approximately 30 to 40% residual plasma. In an effort to further decrease the residual plasma, two in vitro studies were conducted with PLTs suspended in 5% plasma and a reformulated PAS-3, named PAS-5, that contains additional salts, glucose, and bicarbonate. In Study 1, PLTs suspended in 5% plasma/95% PAS-5 were prepared directly on a separator (Amicus, Fenwal, Inc.) without additional centrifugation or washing. In Study 2, a double unit of hyperconcentrated Amicus PLTs in plasma was collected, divided, and centrifuged to prepare a control unit in 100% plasma and a paired test unit in 5% plasma/95% PAS-5. The in vitro properties of PLTs were assessed in both studies during 7-day storage at 20 to 24°C with continuous agitation. In Study 1, PLT concentration, pH, mean PLT volume (MPV), HCO(3)(-), pCO(2), pO(2), lactate dehydrogenase, and hypotonic shock response (HSR) did not significantly change during storage. By Day 7, glucose levels and morphology scores modestly decreased (17.6 and 14.4%, respectively) and lactate levels modestly increased (to 7.2 mmol/L). In Study 2, MPV, pH, glucose, pO(2), HSR, and morphology were comparable in control and test PLTs during 7-day storage. Glucose consumption and lactate production were significantly less in test versus control PLTs (p≤0.0015). Extent of shape change and %CD62P-positive test PLTs were less than those of controls (p<0.001). Apheresis PLTs suspended in 5% plasma/95% PAS-5 maintained in vitro properties during 7-day storage. © 2011 American Association of Blood Banks.

  12. H2O2 production rate in Lactobacillus johnsonii is modulated via the interplay of a heterodimeric flavin oxidoreductase with a soluble 28 Kd PAS domain containing protein.

    Science.gov (United States)

    Valladares, Ricardo B; Graves, Christina; Wright, Kaitlyn; Gardner, Christopher L; Lorca, Graciela L; Gonzalez, Claudio F

    2015-01-01

    Host and commensals crosstalk, mediated by reactive oxygen species (ROS), has triggered a growing scientific interest to understand the mechanisms governing such interaction. However, the majority of the scientific studies published do not evaluate the ROS production by commensals bacteria. In this context we recently showed that Lactobacillus johnsonii N6.2, a strain of probiotic value, modulates the activity of the critical enzymes 2,3-indoleamine dioxygenase via H2O2 production. L. johnsonii N6.2 by decreasing IDO activity, is able to modify the tryptophan/kynurenine ratio in the host blood with further systemic consequences. Understanding the mechanisms of H2O2 production is critical to predict the probiotic value of these strains and to optimize bacterial biomass production in industrial processes. We performed a transcriptome analysis to identify genes differentially expressed in L. johnsonii N6.2 cells collected from cultures grown under different aeration conditions. Herein we described the biochemical characteristics of a heterodimeric FMN reductase (FRedA/B) whose in vitro activity is controlled by LjPAS protein with a typical Per-Arnst-Sim (PAS) sensor domain. Interestingly, LjPAS is fused to the FMN reductase domains in other lactobacillaceae. In L. johnsonii, LjPAS is encoded by an independent gene which expression is repressed under anaerobic conditions (>3 fold). Purified LjPAS was able to slow down the FRedA/B initial activity rate when the holoenzyme precursors (FredA, FredB, and FMN) were mixed in vitro. Altogether the results obtained suggest that LjPAS module regulates the H2O2 production helping the cells to minimize oxidative stress in response to environmental conditions.

  13. Comparison of multi-fiber reproducibility of PAS-MRI and Q-ball with empirical multiple b-value HARDI

    Science.gov (United States)

    Nath, Vishwesh; Schilling, Kurt G.; Blaber, Justin A.; Ding, Zhaohua; Anderson, Adam W.; Landman, Bennett A.

    2017-02-01

    Crossing fibers are prevalent in human brains and a subject of intense interest for neuroscience. Diffusion tensor imaging (DTI) can resolve tissue orientation but is blind to crossing fibers. Many advanced diffusion-weighted magnetic resolution imaging (MRI) approaches have been presented to extract crossing-fibers from high angular resolution diffusion imaging (HARDI), but the relative sensitivity and specificity of approaches remains unclear. Here, we examine two leading approaches (PAS and q-ball) in the context of a large-scale, single subject reproducibility study. A single healthy individual was scanned 11 times with 96 diffusion weighted directions and 10 reference volumes for each of five b-values (1000, 1500, 2000, 2500, 3000 s/mm2) for a total of 5830 volumes (over the course of three sessions). We examined the reproducibility of the number of fibers per voxel, volume fraction, and crossing-fiber angles. For each method, we determined the minimum resolvable angle for each acquisition. Reproducibility of fiber counts per voxel was generally high ( 80% consensus for PAS and 70% for q-ball), but there was substantial bias between individual repetitions and model estimated with all data ( 10% lower consensus for PAS and 15% lower for q-ball). Both PAS and q-ball predominantly discovered fibers crossing at near 90 degrees, but reproducibility was higher for PAS across most measures. Within voxels with low anisotropy, q-ball finds more intra-voxel structure; meanwhile, PAS resolves multiple fibers at greater than 75 degrees for more voxels. These results can inform researchers when deciding between HARDI approaches or interpreting findings across studies.

  14. Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation.

    Science.gov (United States)

    Corrada, Dario; Soshilov, Anatoly A; Denison, Michael S; Bonati, Laura

    2016-06-01

    The Aryl hydrocarbon Receptor (AhR) is a transcription factor that mediates the biochemical response to xenobiotics and the toxic effects of a number of environmental contaminants, including dioxins. Recently, endogenous regulatory roles for the AhR in normal physiology and development have also been reported, thus extending the interest in understanding its molecular mechanisms of activation. Since dimerization with the AhR Nuclear Translocator (ARNT) protein, occurring through the Helix-Loop-Helix (HLH) and PER-ARNT-SIM (PAS) domains, is needed to convert the AhR into its transcriptionally active form, deciphering the AhR:ARNT dimerization mode would provide insights into the mechanisms of AhR transformation. Here we present homology models of the murine AhR:ARNT PAS domain dimer developed using recently available X-ray structures of other bHLH-PAS protein dimers. Due to the different reciprocal orientation and interaction surfaces in the different template dimers, two alternative models were developed for both the PAS-A and PAS-B dimers and they were characterized by combining a number of computational evaluations. Both well-established hot spot prediction methods and new approaches to analyze individual residue and residue-pairwise contributions to the MM-GBSA binding free energies were adopted to predict residues critical for dimer stabilization. On this basis, a mutagenesis strategy for both the murine AhR and ARNT proteins was designed and ligand-dependent DNA binding ability of the AhR:ARNT heterodimer mutants was evaluated. While functional analysis disfavored the HIF2α:ARNT heterodimer-based PAS-B model, most mutants derived from the CLOCK:BMAL1-based AhR:ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of DNA binding, suggesting this latter model as the most suitable for describing AhR:ARNT dimerization. These novel results open new research directions focused at elucidating basic molecular mechanisms underlying the

  15. Pas de deux: An Intricate Dance of Anther Smut and Its Host

    Directory of Open Access Journals (Sweden)

    Su San Toh

    2018-02-01

    Full Text Available The successful interaction between pathogen/parasite and host requires a delicate balance between fitness of the former and survival of the latter. To optimize fitness a parasite/pathogen must effectively create an environment conducive to reproductive success, while simultaneously avoiding or minimizing detrimental host defense response. The association between Microbotryum lychnidis-dioicae and its host Silene latifolia serves as an excellent model to examine such interactions. This fungus is part of a species complex that infects species of the Caryophyllaceae, replacing pollen with the fungal spores. In the current study, transcriptome analyses of the fungus and its host were conducted during discrete stages of bud development so as to identify changes in fungal gene expression that lead to spore development and to identify changes associated with infection in the host plant. In contrast to early biotrophic phase stages of infection for the fungus, the latter stages involve tissue necrosis and in the case of infected female flowers, further changes in the developmental program in which the ovary aborts and a pseudoanther is produced. Transcriptome analysis via Illumina RNA sequencing revealed enrichment of fungal genes encoding small secreted proteins, with hallmarks of effectors and genes found to be relatively unique to the Microbotryum species complex. Host gene expression analyses also identified interesting sets of genes up-regulated, including those involving stress response, host defense response, and several agamous-like MADS-box genes (AGL61 and AGL80, predicted to interact and be involved in male gametophyte development.

  16. Comparison of irradiated and hydrogen implanted German RPV steels using PAS technique

    Energy Technology Data Exchange (ETDEWEB)

    Pecko, Stanislav, E-mail: stanislav.pecko@stuba.sk; Sojak, Stanislav; Slugeň, Vladimír

    2015-12-15

    Highlights: • German RPV steels were originally studied by positron annihilation spectroscopy. • Neutron irradiated and hydrogen ion implanted specimens were studied. • Both irradiation ways caused to increase of defect size. • We determined that the defect size was higher in implanted specimens. - Abstract: Radiation degradation of nuclear materials can be experimentally simulated via ion implantation. In our case, German reactor pressure vessel (RPV) steels were studied by positron annihilation lifetime spectroscopy (PALS). This spectroscopic method is a really effective tool for the evaluation of microstructural changes and for the analysis of degradation of reactor steels due to irradiation. German commercial reactor pressure vessel steels, originally from CARISMA program, were used in our study. The German experimental reactor VAK was selected as the proper irradiation facility in the 1980s. A specimen in as-received state and 2 different irradiated cuts from the same material were measured by PALS and size of defects with their intensity was indentified. Afterwards there was prepared an experiment with concern in simulation of neutron irradiation by hydrogen ion implantation on a linear accelerator with energy of 100 keV. Results are concerning on comparison between defects caused by neutron irradiation and hydrogen implantation. The size and intensity of defects reached a similar level as in the specimens irradiated in the nuclear reactor due to hydrogen ions implantation.

  17. Comparison of irradiated and hydrogen implanted German RPV steels using PAS technique

    Science.gov (United States)

    Pecko, Stanislav; Sojak, Stanislav; Slugeň, Vladimír

    2015-12-01

    Radiation degradation of nuclear materials can be experimentally simulated via ion implantation. In our case, German reactor pressure vessel (RPV) steels were studied by positron annihilation lifetime spectroscopy (PALS). This spectroscopic method is a really effective tool for the evaluation of microstructural changes and for the analysis of degradation of reactor steels due to irradiation. German commercial reactor pressure vessel steels, originally from CARISMA program, were used in our study. The German experimental reactor VAK was selected as the proper irradiation facility in the 1980s. A specimen in as-received state and 2 different irradiated cuts from the same material were measured by PALS and size of defects with their intensity was indentified. Afterwards there was prepared an experiment with concern in simulation of neutron irradiation by hydrogen ion implantation on a linear accelerator with energy of 100 keV. Results are concerning on comparison between defects caused by neutron irradiation and hydrogen implantation. The size and intensity of defects reached a similar level as in the specimens irradiated in the nuclear reactor due to hydrogen ions implantation.

  18. Comparative study of irradiated and hydrogen implantation damaged German RPV steels from PAS point of view

    Science.gov (United States)

    Pecko, Stanislav; Sojak, Stanislav; Slugeň, Vladimír

    2014-09-01

    Commercial German reactor pressure vessel (RPV) steels were studied by positron annihilation lifetime spectroscopy (PALS). This unique non-destructive method can be effectively applied for the evaluation of microstructural changes and for the analysis of degradation of reactor steels due to neutron irradiation and proton implantation. Studied specimens of German reactor pressure vessel steels are originally from CARINA/CARISMA program. Eight specimens were measured in as-received state and two specimens were irradiated by neutrons in German experimental reactor VAK (Versuchsatomkraftwerk Kahl) in the 1980s. One of the specimens which was also in as-received and neutron irradiated condition was also used for simulation of neutron damage by hydrogen nuclei implantation. Defects with the size of about 1-2 vacancies with relatively small contribution (with intensity on the level of 20-40%) were observed in "as-received" steels. A significant increase in the size of the induced defects due to neutron damage was observed at a level of 2-3 vacancies in the irradiated specimens. The size and intensity of defects reached a similar level as in the specimens irradiated in nuclear reactor due to hydrogen ions implantation with energy of 100 keV (up to the depth <500 nm). This could confirm the ability to simulate neutron damage by ion implantation.

  19. Annual earnings announcements and market reaction: The case of a small capital market

    DEFF Research Database (Denmark)

    Lønroth, Helle Langhoff; Møller, Peder Fredslund; Thinggaard, Frank

    suggest that only a model based on reported IBES-estimates of earnings per share shortly before earnings release is descriptive of the market´s expectations. Some of these findings contradict the results in the only published 17 year old Danish event study on annual earnings announcements......A rich body of evidence exists on the relationship between security returns and corporate annual earnings announcements for countries with highly active capital markets. This paper presents some recent findings for a capital market at the other end of the scale: the small Danish stock market. Our...... results are based on the events study methodology, using the market model to calculate abnormal returns. In the first part of the paper we find that the Danish stock market extracts most of the information content of the earnings release on the announcement date and the day after. Significant average...

  20. Company stock prices before and after public announcements related to oncology drugs.

    Science.gov (United States)

    Rothenstein, Jeffrey M; Tomlinson, George; Tannock, Ian F; Detsky, Allan S

    2011-10-19

    Phase III clinical trials and Food and Drug Administration (FDA) regulatory decisions are critical for success of new drugs and can influence a company's market valuation. Knowledge of trial results before they are made public (ie, "inside information") can affect the price of a drug company's stock. We examined the stock prices of companies before and after public announcements regarding experimental anticancer drugs owned by the companies. We identified drugs that were undergoing evaluation in phase III trials or for regulatory approval by the US FDA from January 2000 to January 2009. Stock prices of companies that owned such drugs were analyzed for 120 trading days before and after the first public announcement of 1) results of clinical trials with positive and negative outcomes and 2) positive and negative regulatory decisions. All statistical tests were two-sided. We identified public announcements from 23 positive trials and 36 negative trials and from 41 positive and nine negative FDA regulatory decisions. The mean stock price for the 120 trading days before a phase III clinical trial announcement increased by 13.7% (95% confidence interval = -2.2% to 29.6%) for companies that reported positive trials and decreased by 0.7% (95% confidence interval = -13.8% to 12.3%) for companies that reported negative trials (P = .09). In a post hoc analysis comparing the stock price averaged over 60 trading days before and after day -60 relative to the clinical trial announcement, the mean stock price increased by 9.4% for companies that reported positive trials and decreased by 4.5% for companies that reported negative trials (P = .03). Changes in company stock prices before FDA regulatory decisions did not differ statistically between companies with positive decision and companies with negative decisions. Trends in company stock prices before the first public announcement differ for companies that report positive vs negative trials. This finding has important legal and

  1. Interior Lighting Campaign Adds Luminaire Categories; Announces 2018 Recognition Event

    Energy Technology Data Exchange (ETDEWEB)

    Sandahl, Linda J.; Myer, Michael

    2017-11-05

    This article will be published in the November issue of the International Facility Management Association's sustainability newsletter. The article both informs facility managers of the Interior Lighting Campaign, and invites them to participate. Highlights include the new types of lamps recently included along with program details.

  2. Winners announced in seventh annual Home Sweet Home recipe contest

    OpenAIRE

    Gehrt, Katie

    2008-01-01

    Ten recipes were selected from nearly 250 submitted by students' family members during the sixth annual Home Sweet Home Recipe Contest, sponsored by the Virginia Tech Office of Student Programs' Housing and Dining Services, a department within the Division of Student Affairs.

  3. 78 FR 30328 - Announcement of National Geospatial Advisory Committee Meeting

    Science.gov (United States)

    2013-05-22

    ... NSDI Strategic Plan Geospatial Platform OMB Circular A-16 Portfolio Management Landsat Advisory Group... composed of representatives from governmental, private sector, non-profit, and academic organizations, was established to advise the Federal Geographic Data Committee on management of Federal geospatial programs, the...

  4. 77 FR 52053 - Announcement of National Geospatial Advisory Committee Meeting

    Science.gov (United States)

    2012-08-28

    ... established to advise the Federal Geographic Data Committee on management of Federal geospatial programs, the development of the National Spatial Data Infrastructure, and the implementation of Office of Management and Budget (OMB) Circular A-16. Topics to be addressed at the meeting include: Leadership Dialogue Geospatial...

  5. Pas de deux: An Intricate Dance of Anther Smut and Its Host.

    Science.gov (United States)

    Toh, Su San; Chen, Zehua; Rouchka, Eric C; Schultz, David J; Cuomo, Christina A; Perlin, Michael H

    2017-12-01

    The successful interaction between pathogen/parasite and host requires a delicate balance between fitness of the former and survival of the latter. To optimize fitness a parasite/pathogen must effectively create an environment conducive to reproductive success, while simultaneously avoiding or minimizing detrimental host defense response. The association between Microbotryum lychnidis-dioicae and its host, Silene latifolia, serves as an excellent model to examine such interactions. This fungus is part of a species complex that infects species of the Caryophyllaceae, replacing pollen with the fungal spores. In the current study, transcriptome analyses of the fungus and its host were conducted during discrete stages of bud development so as to identify changes in fungal gene expression that lead to spore development and to identify changes associated with infection in the host plant. In contrast to early biotrophic phase stages of infection for the fungus, the latter stages involve tissue necrosis and in the case of infected female flowers, further changes in the developmental program in which the ovary aborts and a pseudoanther is produced. Transcriptome analysis via Illumina RNA sequencing revealed enrichment of fungal genes encoding small secreted proteins, with hallmarks of effectors and genes found to be relatively unique to the Microbotryum species complex. Host gene expression analyses also identified interesting sets of genes up-regulated, including those involving stress response, host defense response and several agamous-like MADS-box genes (AGL61 and AGL80), predicted to interact and be involved in male gametophyte development. Copyright © 2017, G3: Genes, Genomes, Genetics.

  6. Comparative study of irradiated and hydrogen implantation damaged German RPV steels from PAS point of view

    Energy Technology Data Exchange (ETDEWEB)

    Pecko, Stanislav, E-mail: stanislav.pecko@stuba.sk; Sojak, Stanislav; Slugeň, Vladimír

    2014-09-01

    Highlights: • We used positron annihilation spectroscopy to study German RPV steels. • We examine microstructural changes in the studied specimens. • Simulation of neutron irradiation was performed by hydrogen ion implantation. • No large voids or vacancy clusters were formed due to irradiation or implantation. - Abstract: Commercial German reactor pressure vessel (RPV) steels were studied by positron annihilation lifetime spectroscopy (PALS). This unique non-destructive method can be effectively applied for the evaluation of microstructural changes and for the analysis of degradation of reactor steels due to neutron irradiation and proton implantation. Studied specimens of German reactor pressure vessel steels are originally from CARINA/CARISMA program. Eight specimens were measured in as-received state and two specimens were irradiated by neutrons in German experimental reactor VAK (Versuchsatomkraftwerk Kahl) in the 1980s. One of the specimens which was also in as-received and neutron irradiated condition was also used for simulation of neutron damage by hydrogen nuclei implantation. Defects with the size of about 1–2 vacancies with relatively small contribution (with intensity on the level of 20–40%) were observed in “as-received” steels. A significant increase in the size of the induced defects due to neutron damage was observed at a level of 2–3 vacancies in the irradiated specimens. The size and intensity of defects reached a similar level as in the specimens irradiated in nuclear reactor due to hydrogen ions implantation with energy of 100 keV (up to the depth <500 nm). This could confirm the ability to simulate neutron damage by ion implantation.

  7. The Effect of Earnings Announcements on Firm Value: A Quantile Regression Approach

    Directory of Open Access Journals (Sweden)

    Ali GÜVERCİN

    2016-03-01

    Full Text Available In this study, we examine the effect of earnings announcements on firm value by looking at the relationship at different points of the conditional distribution. The analysis covers non-financial companies listed in Borsa Istanbul’s BIST100 index for the 2009-2013 years. The study also takes into account the effect of earnings persistence, whether the firm pay dividends, and brand name on the relationship between earnings announcements and firm value. Our analysis also investigates that relationship using a accurately method, namely Quantile Regression, by looking at the relationship at different points of the conditional distribution.

  8. 75 FR 21301 - Office of Clinical and Preventive Services; Elder Care Initiative Long-Term Care Grant Program

    Science.gov (United States)

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Indian Health Service Office of Clinical and Preventive Services; Elder Care Initiative Long-Term Care Grant Program Announcement Type: New. Funding Announcement Number: HHS-2010-IHS-EHC-0001...

  9. 75 FR 20326 - Technology Innovation Program (TIP) Notice of Availability of Funds and Announcement of Public...

    Science.gov (United States)

    2010-04-19

    ... detailed scientific rationale and description of the challenges to accomplish scale-up of the process(es...) addressing the scientific and technical merit of the proposal. The trial results must be essential for... 2009 issue of Fortune magazine's Fortune 1000 list. (Note that the revenue amount will be updated...

  10. 75 FR 14559 - Household Water Well System Grant Program Announcement of Application Deadlines and Funding

    Science.gov (United States)

    2010-03-26

    ... Information A. Criteria This section contains instructions and guidelines on preparing the project proposal... object class identified in section B of the Budget Information form (SF-424A). Detailed calculations must... through http://www.grants.gov ( Grants.gov ), following the instructions on that Web site. Submit...

  11. 76 FR 40679 - Household Water Well System Grant Program Announcement of Application Deadlines and Funding

    Science.gov (United States)

    2011-07-11

    ... Information A. Criteria This section contains instructions and guidelines on preparing the project proposal... object class identified in section B of the Budget Information form (SF-424A). Detailed calculations must... ). Submit electronic applications through Grants.gov , following the instructions on that Web site. 2. Paper...

  12. 77 FR 16251 - Announcement of Funding Awards, HOPE VI Revitalization Grant Program, Fiscal Year 2010

    Science.gov (United States)

    2012-03-20

    ..., 777 Grant Street, Denver, CO 80203- 3501. 5 Housing Authority of the City of 18,400,000.00 Alexander..., Department of Housing and Urban Development, 451 Seventh Street SW., Room 4130, Washington, DC 20410... to the HUD Web site at: http://portal.hud.gov/hudportal/HUD?src=/press/press_releases_media...

  13. 77 FR 41436 - Announcement of Funding Awards; Fair Housing Initiatives Program Fiscal Year 2012

    Science.gov (United States)

    2012-07-13

    ....00 Suite 100, Washington, DC 20019. Piedmont Housing Alliance, 1215 East Market Street, Karen... Alder Street, Scranton, PA 18505. Legal Aid Society of Palm Beach County, Inc., 423 Fern Robert Bertisch...-6113..... 3 125,000.00 16503. Legal Aid Society of Palm Beach County, Inc., 423 Fern Robert Bertisch...

  14. 76 FR 58830 - Announcement of Funding Awards; Fair Housing Initiatives Program Fiscal Year (FY) 2008

    Science.gov (United States)

    2011-09-22

    ... Building, Des (515) 281-9086 7 67,126.00 Moines, Iowa 50319 ACORN Associates: 953 E. Sahara Avenue, D-18... Main (508) 752-3718 1 232,000.00 Street, Worchester, MA 01608 Legal Assistance of Western New York, Inc...

  15. 78 FR 6334 - Housing Choice Voucher Program; Office of Public and Indian Housing Announcement of Funding...

    Science.gov (United States)

    2013-01-30

    ... WEST JULIAN ST, SAN JOSE, CA 8 116,380 95110. CT: WATERBURY HA 2 LAKEWOOD RD, WATERBURY, CT 3 22,962... SHERMAN ST, RM 518, DENVER, 39 268,674 CO 80203. CT: WATERBURY HA 2 LAKEWOOD RD, WATERBURY, CT 11 87,187...: WATERBURY HA 2 LAKEWOOD RD, WATERBURY, CT 0 2,200 06704. CT: STAMFORD HA 22 CLINTON AVE, STAMFORD, CT 0 3...

  16. 76 FR 9588 - Announcement of Funding Awards for the Rural Housing and Economic Development Program; Fiscal...

    Science.gov (United States)

    2011-02-18

    ... organizations, community ] development corporations, Federally recognized Indian Tribes, State housing finance..., Inc AL 300,000.00 Moenkopi Developers Corporation, Inc......... AZ 257,280.00 The Primavera Foundation... Chippewa... MN 170,000.00 Bois Forte Band of Chippewa MN 298,073.00 Esther Stewart Buford Foundation MS 180...

  17. 77 FR 53214 - Announcement of Funding Awards; Service Coordinators in Multifamily Housing Program, Fiscal Year...

    Science.gov (United States)

    2012-08-31

    ... Anderson, a limited Anderson. partnership. IN Glick Wesley Park Wesley Park 1304 Wesley Rd....... Auburn 72...,430 Housing Corporation. Villa Dr.. MI Elderly Housing Thomas F. Taylor 36500 Marquette St... Westland...

  18. 75 FR 43177 - Medicare and Medicaid Programs; Announcement of an Application From a Hospital Requesting Waiver...

    Science.gov (United States)

    2010-07-23

    ... appointment to view public comments, phone 1-800-743-3951. I. Background Organ Procurement Organizations (OPOs... an Application From a Hospital Requesting Waiver for Organ Procurement Service Area AGENCY: Centers... into an agreement with its designated Organ Procurement Organization (OPO). The request was made in...

  19. 75 FR 59272 - Medicare and Medicaid Programs; Announcement of an Application from a Hospital Requesting Waiver...

    Science.gov (United States)

    2010-09-27

    ... appointment to view public comments, phone 1-800-743-3951. I. Background Organ Procurement Organizations (OPOs... an Application from a Hospital Requesting Waiver for Organ Procurement Service Area AGENCY: Centers... into an agreement with its designated Organ Procurement Organization (OPO). The request was made in...

  20. 78 FR 72095 - Announcement of Funding Awards for Fiscal Year 2013 Research Partnerships Program

    Science.gov (United States)

    2013-12-02

    ... Housing on Young Children.'' Dr. Sandra Newman, Principal Investigator, 615 North Wolfe Street, W1600.... Grant Award: $170,000. Region V 11. Ohio State University, ``Aging in Place: Managing the Use of Reverse.... BILLING CODE 4210-67-P ...

  1. 76 FR 17738 - Over-the-Road Bus Accessibility Program Announcement of Project Selections

    Science.gov (United States)

    2011-03-30

    ... help finance the incremental capital and training costs of complying with DOT's over-the-road bus...--New York, One Administrator, Region 7-- Bowling Green, Room 429, New York, NY Kansas City, MO, 901... Metropolitan Office, Region 2-- New York, One Bowling Green, Room 428, New York, NY 10004-1415, Tel. 212-668...

  2. 76 FR 58822 - Announcement of Funding Awards; Fair Housing Initiatives Program; Fiscal Year 2010

    Science.gov (United States)

    2011-09-22

    ..., 413-233-1668.... 1 $121,637.00 2403. Champlain Valley Office of Economic Opportunity: Kevin Stapleton.... Neighborhood Economic Development Advocacy Project: Sarah Ludwig, 212-680-5100.... 2 125,000.00 176 Grand... Legal Equality, Inc.: 525 Cindy Hurst, 419-255-0814..... 5 499,999.00 Jefferson Avenue, Suite 300...

  3. 77 FR 6573 - Announcement of Funding Awards; Fair Housing Initiatives Program Fiscal Year 2011

    Science.gov (United States)

    2012-02-08

    ... 60430. Fair Housing Center of Metropolitan Detroit, Clifford Schrupp, 313-963-1274....... 5 299,525.00... Borelli, 559-244-2950........ 9 259,034.00 333 W. Shaw Avenue, Suite 14, Fresno, CA 93704. Greater Napa...

  4. 76 FR 78926 - Medicare and Medicaid Programs; Announcement of Application From Hospital Requesting Waiver for...

    Science.gov (United States)

    2011-12-20

    ... Organization (OPO) outside of its designated OPO. The request was made in accordance with section 1138(a)(2) of.... Once an OPO has been designated for an area, hospitals in that area that participate in Medicare and Medicaid are required to work with that OPO in providing organs for transplant, pursuant to section 1138(a...

  5. 77 FR 24495 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Science.gov (United States)

    2012-04-24

    ... with its designated Organ Procurement Organization (OPO). The request was made in accordance with... Service Act (42 U.S.C. 273(b)(1)) and our regulations at 42 CFR 486.306. Once an OPO has been designated... with that OPO in providing organs for transplant, pursuant to section 1138(a)(1)(C) of the Social...

  6. 75 FR 5599 - Medicare and Medicaid Programs; Announcement of Applications From Hospitals Requesting Waiver for...

    Science.gov (United States)

    2010-02-03

    ... with their designated Organ Procurement Organization (OPO). Both requests were made in accordance with... OPO has been designated for an area, hospitals in that area that participate in Medicare and Medicaid are required to work with that OPO in providing organs for transplant, pursuant to section 1138(a)(1...

  7. 75 FR 21337 - Medicare and Medicaid Programs; Announcement of an Application From a Hospital Requesting Waiver...

    Science.gov (United States)

    2010-04-23

    ... into an agreement with its designated Organ Procurement Organization (OPO). The request was made in... OPO has been designated for an area, hospitals in that area that participate in Medicare and Medicaid are required to work with that OPO in providing organs for transplant, pursuant to section 1138(a)(1...

  8. 78 FR 19269 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Science.gov (United States)

    2013-03-29

    ... with its designated Organ Procurement Organization (OPO). The request was made in accordance with... Health Service Act (42 U.S.C. 273(b)(1)) and our regulations at 42 CFR 486.306. Once an OPO has been... with that OPO in providing organs for transplant, pursuant to section 1138(a)(1)(C) of the Social...

  9. 78 FR 98 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Science.gov (United States)

    2013-01-02

    ... with its designated Organ Procurement Organization (OPO). The request was made in accordance with... Service Act (42 U.S.C. 273(b)(1)) and our regulations at 42 CFR 486.306. Once an OPO has been designated... with that OPO in providing organs for transplant, pursuant to section 1138(a)(1)(C) of the Social...

  10. 75 FR 59274 - Medicare and Medicaid Programs; Announcement of Application from Hospital Requesting Waiver for...

    Science.gov (United States)

    2010-09-27

    ... with its designated Organ Procurement Organization (OPO). The request was made in accordance with... OPO has been designated for an area, hospitals in that area that participate in Medicare and Medicaid are required to ] work with that OPO in providing organs for transplant, pursuant to section 1138(a)(1...

  11. 77 FR 60703 - Medicare and Medicaid Programs; Announcement of Application From Hospital Requesting Waiver for...

    Science.gov (United States)

    2012-10-04

    ... Organ Procurement Organization (OPO). The request was made in accordance with section 1138(a)(2) of the.... Once an OPO has been designated for an area, hospitals in that area that participate in Medicare and Medicaid are required to work with that OPO in providing organs for transplant, pursuant to section 1138(a...

  12. 77 FR 51539 - Medicare and Medicaid Programs; Announcement of Application From a Hospital Requesting Waiver for...

    Science.gov (United States)

    2012-08-24

    ... Organ Procurement Organization (OPO). The request was made in accordance with section 1138(a)(2) of the... Service Act (42 U.S.C. 273(b)(1)) and our regulations at 42 CFR 486.306. Once an OPO has been designated... with that OPO in providing organs for transplant, pursuant to section 1138(a)(1)(C) of the Social...

  13. 76 FR 36567 - Announcement of Funding Awards; Indian Community Development Block Grant Program; Fiscal Year 2010

    Science.gov (United States)

    2011-06-22

    ... Develop a 3,000 sq. ft. transition center for Ronde, Honorable Cheryle A. Special Purpose. women. Kennedy... Paula Center. Salazar, Chairwoman, P.O. Box 809, Wells, NV 89835. White Earth Band of the MN 600,000....O. Box 418, White Earth, MN 56591. Wyandotte Nation, Honorable 369,000 Housing Housing...

  14. 78 FR 36232 - Announcement of Funding Awards; Service Coordinators in Multifamily Housing Program, Fiscal Year...

    Science.gov (United States)

    2013-06-17

    .... Homes, Inc. GA....... John Sparks Cc/Sparks Manor 7290 Lester Rd. Union City 85 166,721 Manor, Inc. ID... 176,629 Baptist Church St. Nphc/Dba Alaine Locke Manor. MI....... Fc Plymouth Plymouth Square 20201...

  15. 78 FR 38287 - Household Water Well System Grant Program Announcement of Application Deadlines and Funding

    Science.gov (United States)

    2013-06-26

    ... without endangering the environment. The RUS provides financial and technical assistance to help... located at http://droughtmonitor.unl.edu/ . 2. Emphasis on High Poverty Areas. To the maximum extent... 20% of the population is living in poverty. 3. Emphasis on Targeted Underserved Areas. Loans are...

  16. 75 FR 60781 - Announcement of Funding Awards for Fiscal Year 2010 Tribal Colleges and Universities Program

    Science.gov (United States)

    2010-10-01

    ... College, 124 South First Street, Mahnomen, MN 56557. Grant: $800,000. Region VIII 2. Fort Peck Community College, Craig Smith, Fort Peck Community College, 605 Indian Avenue, Poplar, MT 59201. Grant: $800,000. 3...) of the Department of Housing and Urban Development Reform Act of 1989 (103 Stat. 1987, 42 U.S.C. 3545...

  17. 77 FR 9956 - Announcement of Funding Awards for the Sustainable Communities Regional Planning Grant Program...

    Science.gov (United States)

    2012-02-21

    ... system, open space, and other infrastructure priorities for the region; b. Clearly define a single... sets and other metrics in developing, implementing, monitoring, and assessing the performance goals of...

  18. Student Program for Environmental Excellence in Design (SPEED) Grant - Closed Announcement FY 2015

    Science.gov (United States)

    SPEED aims to increase students’ awareness and understanding of the environmental benefits stemming from increasing fuel efficiency, reducing carbon intensity in transportation fuels, and reducing emissions in advanced vehicles.

  19. Student Program for Environmental Excellence in Design (SPEED) Grant - Closed Announcement FY 2014

    Science.gov (United States)

    SPEED aims to increase students’ awareness and understanding of the environmental benefits stemming from increasing fuel efficiency, reducing carbon intensity in transportation fuels, and reducing emissions in advanced vehicles.

  20. 76 FR 77842 - Announcement of Funding Awards; Indian Community Development Block Grant Program; Fiscal Year 2011

    Science.gov (United States)

    2011-12-14

    ...- Stations. 4219. Chickasaw Nation, Honorable Bill 800,000 Public Facility Community Hospitality House...,000 Housing Rehabilitation.... Rehabilitate Senior Executive Director, P.O. Box 59, Rental Complex... 96013, (530) 335-4809. Poarch Band of Creek Indians of AL, 600,000 Public Facility Community Senior...