Not Stopping at First: Racial Literacy and the Teaching of Barack Obama

Science.gov (United States)

Smith, William L.

2014-01-01

In this article the author speaks to the teaching of Barack Obama in U.S. schools. Drawing from scholarly literature on the heroification of American historical figures in public memory, the author argues that focusing on Obama's firstness as an African American may lead students to have incomplete and misleading understandings of what the…

Barack Obama: apoios recebidos na campanha presidencial na visão do New York Times

OpenAIRE

Maria Inez Mateus Dota

2010-01-01

Este estudio tiene por objetivo discutir como son presentados y contextualizados los apoyos dados a Barack Obama, manifiestos en el diario The New York Times, en el periodo de la campaña presidencial del 2008.

What is profound?

DEFF Research Database (Denmark)

Sobisch, Jan-Ulrich

2013-01-01

Discussing the question, which elements on the path are to be considered profound. While a general view is that the most subtle practises are also the most profound, 'Jig-rten-mgon-po maintains that the most fundamental one's are to be considered the most profound....

Barack Obama a Blízký východ

OpenAIRE

Černý, Ondřej

2011-01-01

The thesis named Barack Obama and Middle East analyzes American foreign policy to-wards the countries of the Middle East region - Iraq, Iran and Israel. After two con-secutive terms of George W. Bush, new policies of the Obama administration are de-fined with the Middle East still in its centre. This paper answers three basic questions: What is Obama's desirable Middle East policy? In what aspects it is different from the steps of his predecessor? To what extent are the pre-election promises ...

Barack Obama: apoios recebidos na campanha presidencial na visão do New York Times

Directory of Open Access Journals (Sweden)

Maria Inez Mateus Dota

2010-12-01

Full Text Available Este estudio tiene por objetivo discutir como son presentados y contextualizados los apoyos dados a Barack Obama, manifiestos en el diario The New York Times, en el periodo de la campaña presidencial del 2008.

European vector of foreign policy of the Barack Obama administration

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M. Yu. Lymar

2014-07-01

Full Text Available The article researches the basic principles and conceptual approaches to shaping the foreign policy of the   Barack Obama. It is noted that: the foreign policy of the United States should strengthen U.S. global leadership; the special role in determining the directions of U.S. foreign policy is given to the principle of «smart power»; it is important to cooperate with international organizations; the dialogue with Europe should be based on the axis of NATO­EU. This study examines the main areas of cooperation with the European Union, including: overcoming the global crisis and reforming the international financial system; settling the situation in Afghanistan and Pakistan; ensuring energy security; finding the ways to prevent new climate changes; defusing the situation which is related to the deployment of U.S. strategic plans in Eastern Europe. It is analyzed the beginning of Obama administration activity on inetnational area, discussed its achievements and shortcomings. The article marks that the USA focuses its attention more on the «Asian vector» and it causes some concern of the European Community. Attention is drawn to the main priorities of «National Security Strategy 2010». The author concludes that despite the absence of significant changes in U.S.­European relations during the first term of Barack Obama as the president, the current era of transatlantic relations has witnessed a process of constant functional cooperation with varying success.

Weltanschauung und Politik in den heutigen USA. Barack Obama und der „neue Kulturkampf“ um die Führung der anglo-amerikanischen Weltmacht

OpenAIRE

Roland Benedikter

2010-01-01

The relationship between Worldviews and Politics in the USA today. Barack Obama and the “new cultural battle” for political supremacy in the US English Summary: This article provides an analysis of the current relationship between Politics, Culture and Worldviews in the USA under Barack Obama. The present “great Obama divide” of US domestic politics consists in the division between institutional and contextual (cultural and worldview) politics. Obama has induced their current opposition w...

[Barack Obama et le « rêve américain »

OpenAIRE

Dumont , Gérard-François

2009-01-01

International audience; The “American dream” : an old concept which incorporates a strong demographic component; indeed it is inseparable from the migratory flows involving the United States. Barack Obama’s election also integrated this aspect, with the new president declaring during his campaign that he wanted to keep the American dream alive.; Notion ancienne, le « rêve américain » compte une forte dimension démographique, car il est indissociable des courants migratoires liés aux États-Uni...

Presidents and health reform: from Franklin D. Roosevelt to Barack Obama.

Science.gov (United States)

Morone, James A

2010-06-01

The health care reforms that President Barack Obama signed into law in March 2010 were seventy-five years in the making. Since Franklin D. Roosevelt, U.S. presidents have struggled to enact national health care reform; most failed. This article explores the highly charged political landscape in which Obama maneuvered and the skills he brought to bear. It contrasts his accomplishments with the experiences of his Oval Office predecessors. Going forward, implementation poses formidable challenges for Democrats, Republicans, and the political process itself.

Gobierno de Barack Obama: una explicación desde el institucionalismo

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Javier Garay

2010-11-01

Full Text Available Este artículo trata de explicar, desde el institucionalismo, los problemas domésticos que ha tenido el gobierno de Barack Obama en los Estados Unidos. Se parte del hecho que este gobierno ha tenido una buena imagen en el ámbito internacional, pero ha tenido dificultades para generar consensos en el ámbito doméstico. Para esto, en el artículo se afirma que este gobierno demócrata se aleja de los valores, cultura y sociedad estadounidenses.

Has the Dream Been Fulfilled? Dr. Martin Luther King, Jr. & President Barack Hussein Obama

Science.gov (United States)

Robinson, Nichelle Boyd; Moore, Virginia J.; Williams-Black, Thea H.

2015-01-01

Equality for all was the dream of Dr. Martin Luther King, Jr. and he knowingly laid the foundation for and inspired the first African-American President of the United States of America, Barack Hussein Obama, who also had the dream of "Change" for America. These men exhibited how working together can make dreams become reality. For the…

The Relationship between Racial Identity and Perceived Significance of the Election of President Barack Obama among African American Mothers.

Science.gov (United States)

Franco, Marisa; Smith-Bynum, Mia

2016-01-01

African American women's racial identity is a major determinant for how they interpret the world around them, yet there is little research examining how specific aspects of racial identity are linked with attitudes about an event that has been highly significant for African-Americans: the election of President Barack Obama. The current study examined the relationship between African American mothers' racial identity and their perceived significance of the election of President Barack Obama as an indicator of reduced systemic and actual racism for African Americans, using a sample of 110 African American mothers residing in a Northeastern metropolitan area. Results revealed that racial centrality and assimilation positively predicted perceived significance of President Obama's election for diminishing racism. Implications and future directions are discussed.

Standing in the shadows of Niebuhr : U.S. president Barack Obama and Reinhold Niebuhr’s Christian realism

NARCIS (Netherlands)

Kamminga, M.R.

2011-01-01

U.S. president Barack Obama has called renowned Christian moral and political theologian Reinhold Niebuhr a major intellectual influence. Although Obama’s acknowledgement has been widely noted and discussed, a more systematic analysis and evaluation of the extent to which Obama has actually taken

Barack Obama and His-Story : Paradox of Hybridity and Masculinity in His Autoandrography

OpenAIRE

瀬名波, 栄潤

2008-01-01

This essay, a revision of an oral presentation at NASSS, examines Barack Hussein Obama's 1995 autobiography Dreams from My Father: A Story of Race and Inheritance from literary perspectives as the text introduces not only a postmodern bildungsroman hero of hybridity but the author's paradoxical obsession to paternal heritage. As a result, his autoandrography, a life writing of a man about himself and by himself, represents a familiar story of a man who is trapped by the myth of masculinity. T...

Assessing the Debt: George W. Bush's Legacy and the Future of Public Education under Barack Obama

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Means, Alex; Taylor, Kendall

2010-01-01

This article utilizes Gloria Ladson-Billings' notion of educational debt in order to explore the historical, economic, and cultural politics of education reform under George W. Bush and Barack Obama. It tracks the No Child Left Behind Act across a number of fields in order to claim that Bush's expansion of the educational debt should be understood…

Continuing Inequity through Neoliberalism: The Conveyance of White Dominance in the Educational Policy Speeches of President Barack Obama

Science.gov (United States)

Hairston, Thomas W.

2013-01-01

The purpose of this critical discourse analysis is to examine how the political speeches and statements of President Barack Obama knowingly or unknowingly continue practices and policies of White privilege within educational policy and practice by constructing education in a neoliberal frame. With presidents having the ability to communicate…

Retorika Barack Hussein Obama Dan Susilo Bambang Yudhoyono Dalam Menanggapi Isu Isis Di Dunia

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Livia

2015-07-01

Full Text Available This research discuss about the rhetoric performed by Barack Hussein Obama as President of the United States and Susilo Bambang Yudhoyono as President of the Republic of Indonesia in delivering feedback over the ISIS issue that circulating around the world. ISIS is an organization who commit acts of terrorism in the name of Islam. The United States is known as ‘anti-Islam’ country’s, while Indonesia has the largest Muslim population in the world. Therefore, author used Roland Barthes semiotic to reveal differences in this two figures seen from their rhetoric of verbal and non-verbal language. Thus, we can reveal how this two figures performed their rhetoric over the ISIS issue that conveyed to the international community. Penelitian ini membahas mengenai retorika yang dilakukan oleh Barack Hussein Obama selaku Presiden Amerika Serikat dan Susilo Bambang Yudhoyono selaku Presiden Republik Indonesia dalam memberikan tanggapan mengenai isu ISIS yang beredar di dunia. ISIS merupakan sebuah organisasi yang melakukan tindakan terorisme dengan mengatasnamakan Islam. Amerika Serikat merupakan negara yang dikenal sebagai negara ‘anti Islam’, sedangkan Indonesia merupakan negara dengan penduduk muslim terbanyak di dunia. Oleh karena itu, penulis menggunakan semiotik Roland Barthes untuk mengungkapkan perbedaan retorika kedua tokoh dilihat dari bahasa verbal dan non verbalnya. Dengan demikian, dapat terlihat seperti apa retorika yang dilakukan oleh kedua tokoh yang ingin disampaikan kepada masyarakat internasional terkait isu ISIS.

Barack Obama’s Dreams from My Father and African American Literature

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Daniel Stein

2011-09-01

Full Text Available This article provides a series of close readings of Barack Obama’s autobiography Dreams from My Father. It places the narrative within the history of African American literature and rhetoric and argues that Obama uses the text to create a life story that resonates with central concepts of African American selfhood and black male identity, including double consciousness, invisibility, and black nationalism. The article reads Dreams from My Father as an attempt to arrive at a state of “functional Blackness,” which moves away from questions of racial authenticity and identity politics but recognizes the narrative powers of African American literature to shape a convincing and appealing black self.

Positive emotions and the social broadening effects of Barack Obama.

Science.gov (United States)

Ong, Anthony D; Burrow, Anthony L; Fuller-Rowell, Thomas E

2012-10-01

Past experiments have demonstrated that the cognitive broadening produced by positive emotions may extend to social contexts. Building on this evidence, we hypothesized that positive emotions triggered by thinking about Barack Obama may broaden and expand people's sense of self to include others. Results from an expressive-writing study demonstrated that African American college students prompted to write about Obama immediately prior to and after the 2008 presidential election used more plural self-references, fewer other-references, and more social references. Mediation analyses revealed that writing about Obama increased positive emotions, which in turn increased the likelihood that people thought in terms of more-inclusive superordinate categories (we and us rather than they and them). Implications of these findings for the role of positive emotions in perspective-taking and intergroup relations are considered.

Beyond Post-Racial Narratives: Barack Obama and the (Re)shaping of Racial Memory in US Schools and Society

Science.gov (United States)

Smith, William L.; Brown, Anthony L.

2014-01-01

Drawing from the work of "cultural memory" and "racial formation theory" (Omi and Winant 1994) we explore the ascension of Barack Obama as an illustration of how "race" is understood and remembered. This article focuses on the public media discourse of the 2012 Obama re-election to illustrate how the narrative morphed…

Making a Difference? Evaluating the Impact of President Barack Obama

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James Goldgeier

2010-01-01

Full Text Available Barack Obama prometió durante su campaña electoral poner fin a la guerra en Irak y al mismo tiempo poner a disposición los recursos necesarios para combatir a los Talibán en Afganistán. En marzo, anunció una estrategia para Afganistán y Pakistán centrada en la derrota de Al Qaeda. En agosto, definía la guerra en Afganistán claramente como "una guerra de necesidad". Pero tras recibir del General Stanley McChristal la evaluación de las tropas necesarias para cumplir con la nueva estrategia, Obama empezó una extensa revisión para determinar si se seguía el curso correcto. En West Point en diciembre, el presidente declaró que se enviarían 30.000 nuevas tropas americanas al conflicto, pero prometió acometer la retirada pasados 18 meses.

Fathers of the Nation: Barack Obama Addresses Nelson Mandela

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Elisa Bordin

2014-11-01

Full Text Available This essay analyzes Barack Obama’s Nelson Mandela Memorial speech together with other seminal texts of Obama’s political and personal creed, such as his book Dreams from My Father (1995 and his speech “A More Perfect Union” (2008. This reading becomes helpful to understand Mandela’s transnational power, which Obama uses to comment on the United States by comparing Madiba to other American “fathers of the nation.” Thus, he uproots Mandela’s from a specifically South African legacy, expands his figure, and addresses him as a transnational father of his own nation, whose power, influence, and example transcend South African borders. As a consequence of this enlargement and transnational validation of Mandela’s figure, the speech delivered at the Memorial becomes an occasion to tackle American past and future, while the memory of Madiba and his driving example in Obama’s life serve to reinforce previous positions conveyed in other discourses by the American President, such as the “A More Perfect Union” speech delivered in Philadelphia in 2008.

What Ever Happened To...?

Science.gov (United States)

Early, Margaret

1993-01-01

Notes that the instability of the lexicon of reading instruction suggests the presence of insecurity, not its cause. Looks at selected topics (including Right to Read, Evelyn Wood, individually guided instruction) across time by asking: "What ever happened to...? What is happening to...? and What do I hope will happen to...?" (RS)

Barack Obama – the new charismatic political actor - a discourse analysis

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Ada-Maria Țîrlea

2016-09-01

Full Text Available The American president, Barack Obama, is considered to be one of the most charismatic figures of the 21st century. His speeches are the best asset through which he emphasizes this quality. Although, he hasn’t always been considered to be a successful politician, he made his entrance on the political arena in 2004, when he delivered one of his best speeches. The aim of this paper is to reveal the most important elements of a political discourse that can contribute to creating a good image of a political actor. Using the critical discourse analysis method, we are trying to see if there is a connection between a good, coherent discourse strategy and the charisma of the American leader. The sample will include his 2004 speech, delivered at the Democrats’ Convention, the speech that put him in the eyes of the media as a future American leader.

Mitos y símbolos en la campaña de Barack Obama

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AracelI Soní-Soto

2011-01-01

Full Text Available El uso de las redes sociales en Internet desempeñó un papel fundamental en el triunfo electoral de Barack Obama en las últimas elecciones norteamericanas. El análisis de este fenómeno proporciona la pauta para visualizar su incidencia en la transformación cultural y política de la sociedad en la medida que propició una amplia participación ciudadana, coherente con los ideales democráticos. Sin embargo, el éxito de la contienda no se puede atribuir exclusivamente al uso de los medios, sino a la confluencia entre estos y la significación de los mensajes, cuyo arraigo se encuentra en los mitos de origen y en sus representaciones simbólicas.

Barack Obama, John Lewis, and the Legacy of the Civil Rights Struggle

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Glenn T. Eskew

2012-01-01

Full Text Available The watershed election in 2008 of Barack Obama as the first President of the United States to have African ancestry resulted from the life work of such civil rights activists as U.S. Congressman John Lewis. Born on a sharecropper’s farm in 1940, the African American Lewis grew up in segregated Alabama. As a college student in Nashville, he joined the sit-in protests and volunteered for the original Freedom Ride in 1961. He was elected chairman of the Student Nonviolent Coordinating Committee, becoming the youngest speaker at the March on Washington in 1963. The radical shift to Black ultimately forced Lewis out of SNCC. Consequently Lewis capitalized on the Voting Rights Act of 1965, turned his attentions to voter registration campaigns, and continued working within the system. In 1986 he won election to the U.S. House of Representatives to represent Atlanta’s Fifth Congressional District, a seat he continues to hold today.

Staffs' documentation of participation for adults with profound intellectual disability or profound intellectual and multiple disabilities.

Science.gov (United States)

Talman, Lena; Gustafsson, Christine; Stier, Jonas; Wilder, Jenny

2017-06-21

This study investigated what areas of International Classification of Functioning, Disability and Health were documented in implementation plans for adults with profound intellectual disability or profound intellectual and multiple disabilities with focus on participation. A document analysis of 17 implementation plans was performed and International Classification of Functioning, Disability and Health was used as an analytic tool. One hundred and sixty-three different codes were identified, especially in the components Activities and participation and Environmental factors. Participation was most frequently coded in the chapters Community, social and civic life and Self-care. Overall, the results showed that focus in the implementation plans concerned Self-care and Community, social and civic life. The other life areas in Activities and participation were seldom, or not at all, documented. A deeper focus on participation in the implementation plans and all life areas in the component Activities and participation is needed. It is important that the documentation clearly shows what the adult wants, wishes, and likes in everyday life. It is also important to ensure that the job description for staff contains both life areas and individual preferences so that staff have the possibility to work to fulfill social and individual participation for the target group. Implications for rehabilitation There is a need for functioning working models to increase participation significantly for adults with profound intellectual disability or profound intellectual and multiple disabilities. For these adults, participation is achieved through the assistance of others and support and services carried out must be documented in an implementation plan. The International Classification of Functioning, Disability and Health can be used to support staff and ensure that information about the most important factors in an individual's functioning in their environment is not omitted in

Obama and US policy towards Africa

DEFF Research Database (Denmark)

Olsen, Gorm Rye

2017-01-01

When Barack Obama came into office in January 2009, there were high expectations that he would change the policy towards Africa. It has not happened. Critics maintain that the current policy is not only a continuation of the policy of George W. Bush but has also become increasingly ‘militarized...

Achieving profound anesthesia using the intraosseous technique.

Science.gov (United States)

Coury, K A

1997-10-01

The intraosseous technique has been described as a useful adjunct to primary anesthetic administration. It has several advantages (Table 3) over other supplemental techniques in that it is relatively simple to implement into routine practice, it affords fast, predictable results, and it is relatively painless. The technique has been shown to be very successful in achieving profound pulpal anesthesia when administered as a supplement to the inferior alveolar nerve block and is effective in achieving profound anesthesia in irreversibly inflamed teeth, especially mandibular molars.

Proximal processes of children with profound multiple disabilities

OpenAIRE

Wilder, Jenny

2008-01-01

In this thesis four empirical studies dealt with children with profound multiple disabilities and their parents with regard to: (a) how parents perceived interaction with their children (b) how observed child/parent interaction was linked to behavior style of the children as perceived by the parents (c) how parents of children with profound multiple disabilities perceived child/parent interaction and behavior style of their children in comparison to parents to children without disabilities ma...

Signal processing for the profoundly deaf.

Science.gov (United States)

Boothyroyd, A

1990-01-01

Profound deafness, defined here as a hearing loss in excess of 90 dB, is characterized by high thresholds, reduced hearing range in the intensity and frequency domains, and poor resolution in the frequency and time domains. The high thresholds call for hearing aids with unusually high gains or remote microphones that can be placed close to the signal source. The former option creates acoustic feedback problems for which digital signal processing may yet offer solutions. The latter option calls for carrier wave technology that is already available. The reduced frequency and intensity ranges would appear to call for frequency and/or amplitude compression. It might also be argued, however, that any attempts to compress the acoustic signal into the limited hearing range of the profoundly deaf will be counterproductive because of poor frequency and time resolution, especially when the signal is present in noise. In experiments with a 2-channel compression system, only 1 of 9 subjects showed an improvement of perception with the introduction of fast-release (20 ms) compression. The other 8 experienced no benefit or a slight deterioration of performance. These results support the concept of providing the profoundly deaf with simpler, rather than more complex, patterns, perhaps through the use of feature extraction hearing aids. Data from users of cochlear implants already employing feature extraction techniques also support this concept.

The Need for Career and Technical Education (CTE) Partnerships

Science.gov (United States)

Pawlowski, Brett

2012-01-01

There is an interesting contrast to be found between President Barack Obama and Secretary of Education Arne Duncan: Whereas Obama regularly refers to the current economic situation as the "Great Recession," Duncan instead labels it as "The New Normal." Only one of these can be correct--and the implications for educators are profound. The author…

Energy and climate policies of the USA during the two Barack Obama's terms

International Nuclear Information System (INIS)

Meritet, Sophie; Monjon, Stephanie

2016-02-01

As Barack Obama, from its first presidential campaign to its second term, supported the development of low carbon energies, the protection of climate and of the environment, the development of renewable energies, but also the development of non conventional fossil resources (during his second term), the authors first propose an analysis of the situation of the USA in terms of energy and of greenhouse gas emissions. They highlight the good situation of energy: USA are the first world producer, natural gas is being developed, coal is still present, and electric power is a centre of attention. The evolution of greenhouse gas emissions is discussed for the electricity sector and for the transport sector. In the next part, the authors discuss the content of the different policies implemented during both terms. These policies can be characterized by a strong support to renewable energies at the federal as well as state level, contrasted choices among states in terms of climate policy, federal initiatives for climate (reduction of CO_2 emissions in electric power plants, reduction of methane emissions, reduction of greenhouse gas emissions in other sectors), and actions on the international scene

Destination memory and deception: when I lie to Barack Obama about the moon.

Science.gov (United States)

Haj, Mohamad El; Saloppé, Xavier; Nandrino, Jean Louis

2018-05-01

This study investigates whether deceivers demonstrate high memory of the person to whom lies have been told (i.e., high destination memory). Participants were asked to tell true information (e.g., the heart is a vital organ) and false information (e.g., the moon is bigger than the sun) to pictures of famous people (e.g., Barack Obama) and, in a subsequent recognition test, they had to remember to whom each type of information had previously been told. Participants were also assessed on a deception scale to divide them into two populations (i.e., those with high vs. those with low deception). Participants with high tendency to deceive demonstrated similar destination memory for both false and true information, whereas those with low deception demonstrated higher destination memory for lies than for true information. Individuals with a high tendency to deceive seem to keep track of the destination of both true information and lies to be consistent in their future social interactions, and thus to avoid discovery of their deception. However, the inconsistency between deceiving and the moral standard of individuals with a low tendency to deceive may result in high destination memory in these individuals.

Environmentally profound

Energy Technology Data Exchange (ETDEWEB)

Wang, Rushu [China Yangzte Three Gorges Project Development Corp., Yichang Hubei (China)

1999-09-01

The Three Gorges dam project on the Yangtze river will have a profound effect on the people, the environment and cultural heritage sites. The dam will be the world's biggest and will provide almost 85 BkWh of hydro power per annum. A noticeable benefit will be a greatly reduced incidence of flooding in the Jingjiang reaches of the river. Additional benefits will be improved local navigation, climate and enhanced water quality. The main unwelcome impacts were loss of farmland and resettlement of people but here the government have been particularly careful to provide the relocated people with a reasonable standard of new accommodation and farmland. The loss of natural vegetation will be small but there are endangered species of birds and animals living in the region. A number of negative environmental affects (dust noise, incidence of certain diseases) and how they are to be mitigated are mentioned. (UK)

"Politics 2.0": a campanha online de Barack Obama em 2008

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Wilson Gomes

2009-10-01

Full Text Available O artigo examina o estágio mais recente do padrão das campanhas políticas on-line em eleições presidenciais do ponto de vista dos recursos e instrumentos empregados como parte das operações de comunicação política em redes digitais. Como as eleições americanas de 2008, em geral, e a campanha on-line de Barack Obama, em particular, representam a face mais recente e, até o momento, mais exitosa desse tipo de operação política, os recursos e instrumentos empregados na campanha de Obama serão tomados como um estudo de caso. Trata-se, portanto, de uma prospecção sobre uma experiência de emprego de recursos digitais e on-line em campanhas políticas com o objetivo de reconhecer o patamar a que foram levadas as campanhas on-line e de estabelecer generalizações sobre tendências e possibilidades desse tipo de campanha política. Concluímos que, embora o uso dos recursos de comunicação digital não seja a causa do sucesso da campanha de Obama ou mesmo da mobilização gerada e da popularidade que teve entre o eleitorado jovem, eles certamente fazem parte do ambiente social e político que determinou esses fenômenos.

Makedoonia happening / Margus Kiis

Index Scriptorium Estoniae

Kiis, Margus

2003-01-01

Mooste külalisstuudios viibivad makedoonia tegevuskunstnikud Denis Saraginovski ja Slobodanka Stevceska rühmitusest OPA tutvustasid 8. X Tartu Kunstimajas video vahendusel oma teoseid. Viljeldakse peamiselt happening'i

ProFound: Source Extraction and Application to Modern Survey Data

Science.gov (United States)

Robotham, A. S. G.; Davies, L. J. M.; Driver, S. P.; Koushan, S.; Taranu, D. S.; Casura, S.; Liske, J.

2018-05-01

We introduce PROFOUND, a source finding and image analysis package. PROFOUND provides methods to detect sources in noisy images, generate segmentation maps identifying the pixels belonging to each source, and measure statistics like flux, size, and ellipticity. These inputs are key requirements of PROFIT, our recently released galaxy profiling package, where the design aim is that these two software packages will be used in unison to semi-automatically profile large samples of galaxies. The key novel feature introduced in PROFOUND is that all photometry is executed on dilated segmentation maps that fully contain the identifiable flux, rather than using more traditional circular or ellipse-based photometry. Also, to be less sensitive to pathological segmentation issues, the de-blending is made across saddle points in flux. We apply PROFOUND in a number of simulated and real-world cases, and demonstrate that it behaves reasonably given its stated design goals. In particular, it offers good initial parameter estimation for PROFIT, and also segmentation maps that follow the sometimes complex geometry of resolved sources, whilst capturing nearly all of the flux. A number of bulge-disc decomposition projects are already making use of the PROFOUND and PROFIT pipeline, and adoption is being encouraged by publicly releasing the software for the open source R data analysis platform under an LGPL-3 license on GitHub (github.com/asgr/ProFound).

Human dignity and the profoundly disabled: a theological perspective.

Science.gov (United States)

Matthews, Pia

2011-01-01

One challenge to the concept of human dignity is that it is a rootless notion invoked simply to mask inequalities that inevitably exist between human beings. This privileging of humans is speciesist and its weak point is the profoundly disabled human being. This article argues that far from being a weak point, the profoundly disabled person is a source of strength and witness to the intrinsic dignity that all human beings have by virtue of being human. The disabled represent the reality of human existence that is both strong and fragile. Although human dignity can be understood philosophically its depth is rooted in Christian theological insights. The profoundly disabled occupy a privileged position and share in a theology of mission since they testify to the interdependence of every human being and human dependence on God to a myopic world that only values strength, autonomy and independence.

"What Happened?" Teaching Attribution Theory through Ambiguous Prompts

Science.gov (United States)

McArthur, John

2011-01-01

The concept of attribution, "the act of explaining why something happens or why a person acts a particular way," is typically an abstract concept. This 35-50-minute activity invites students to make a series of attributions by asking them "What happened?" in ambiguous scenes presented in class. Then, students retrospectively identify what…

Using group consciousness theories to understand political activism: case studies of Barack Obama, Hillary Clinton, and Ingo Hasselbach.

Science.gov (United States)

Duncan, Lauren E

2010-12-01

I describe and integrate several theories of group consciousness and collective action, along with 3 case studies of political activists. I have 2 goals: (1) to use the theories to help us understand something puzzling about each life and (2) to use the cases to complicate and expand the theories. Barack Obama's case raises the question of how someone with a politicized Black identity evolved into a politician working for all oppressed people and complicates racial identity development theory. Hillary Clinton's case raises the question of how a middle-class White girl raised in a conservative family became a prominent Democratic Party politician and complicates group consciousness theories by demonstrating the importance of generation and personality. Ingo Hasselbach's (a former German neo-Nazi leader) case illustrates relative deprivation theory and raises the question of whether theories developed to explain subordinate group consciousness can be applied to movements of dominant group consciousness. © 2010 The Author. Journal of Personality © 2010, Wiley Periodicals, Inc.

Observations on Working Psychoanalytically with a Profoundly Amnesic Patient

Directory of Open Access Journals (Sweden)

Paul A. Moore

2017-08-01

Full Text Available Individuals with profound amnesia are markedly impaired in explicitly recalling new episodic events, but appear to preserve the capacity to use information from other sources. Amongst these preserved capacities is the ability to form new memories of an emotional nature – a skill at the heart of developing and sustaining interpersonal relationships. The psychoanalytic study of individuals with profound amnesia might contribute to the understanding the importance of each memory system, including effects on key analytic processes such as transference and countertransference. However, psychoanalytic work in the presence of profound amnesia might also require important technical modifications. In the first report of its kind, we describe observations from a long term psychoanalytic process (72 sessions with an individual (JL who has profound amnesia after an anoxic episode. The nature of therapy was shaped by JL’s impairment in connecting elements that belong to distant (and even relatively close moments in the therapeutic process. However, we were also able to document areas of preservation, in what appears to be a functioning therapeutic alliance. As regards transference, the relationship between JL and his analyst can be viewed as the evolution of a narcissistic transference, and case material is provided that maps this into three phases: (i rejecting; (ii starting to take in; and (iii full use of the analytic space – where each phase exhibits differing degrees of permeability between JL and the analyst. This investigation appears to have important theoretical implications for psychoanalytic practice, and for psychotherapy in general – and not only with regard to brain injured populations. We especially note that it raises questions concerning the mechanism of therapeutic action in psychoanalysis and psychotherapy, and the apparent unimportance of episodic memory for many elements of therapeutic change.

Foveal Processing Under Concurrent Peripheral Load in Profoundly Deaf Adults

Science.gov (United States)

2016-01-01

Development of the visual system typically proceeds in concert with the development of audition. One result is that the visual system of profoundly deaf individuals differs from that of those with typical auditory systems. While past research has suggested deaf people have enhanced attention in the visual periphery, it is still unclear whether or not this enhancement entails deficits in central vision. Profoundly deaf and typically hearing adults were administered a variant of the useful field of view task that independently assessed performance on concurrent central and peripheral tasks. Identification of a foveated target was impaired by a concurrent selective peripheral attention task, more so in profoundly deaf adults than in the typically hearing. Previous findings of enhanced performance on the peripheral task were not replicated. These data are discussed in terms of flexible allocation of spatial attention targeted towards perceived task demands, and support a modified “division of labor” hypothesis whereby attentional resources co-opted to process peripheral space result in reduced resources in the central visual field. PMID:26657078

Misperceiving Bullshit as Profound Is Associated with Favorable Views of Cruz, Rubio, Trump and Conservatism.

Directory of Open Access Journals (Sweden)

Stefan Pfattheicher

Full Text Available The present research investigates the associations between holding favorable views of potential Democratic or Republican candidates for the US presidency 2016 and seeing profoundness in bullshit statements. In this contribution, bullshit is used as a technical term which is defined as communicative expression that lacks content, logic, or truth from the perspective of natural science. We used the Bullshit Receptivity scale (BSR to measure seeing profoundness in bullshit statements. The BSR scale contains statements that have a correct syntactic structure and seem to be sound and meaningful on first reading but are actually vacuous. Participants (N = 196; obtained via Amazon Mechanical Turk rated the profoundness of bullshit statements (using the BSR and provided favorability ratings of three Democratic (Hillary Clinton, Martin O'Malley, and Bernie Sanders and three Republican candidates for US president (Ted Cruz, Marco Rubio, and Donald Trump. Participants also completed a measure of political liberalism/conservatism. Results revealed that favorable views of all three Republican candidates were positively related to judging bullshit statements as profound. The smallest correlation was found for Donald Trump. Although we observe a positive association between bullshit and support for the three Democrat candidates, this relationship is both substantively small and statistically insignificant. The general measure of political liberalism/conservatism was also related to judging bullshit statements as profound in that individuals who were more politically conservative had a higher tendency to see profoundness in bullshit statements. Of note, these results were not due to a general tendency among conservatives to see profoundness in everything: Favorable views of Republican candidates and conservatism were not significantly related to profoundness ratings of mundane statements. In contrast, this was the case for Hillary Clinton and Martin O

Misperceiving Bullshit as Profound Is Associated with Favorable Views of Cruz, Rubio, Trump and Conservatism.

Science.gov (United States)

Pfattheicher, Stefan; Schindler, Simon

2016-01-01

The present research investigates the associations between holding favorable views of potential Democratic or Republican candidates for the US presidency 2016 and seeing profoundness in bullshit statements. In this contribution, bullshit is used as a technical term which is defined as communicative expression that lacks content, logic, or truth from the perspective of natural science. We used the Bullshit Receptivity scale (BSR) to measure seeing profoundness in bullshit statements. The BSR scale contains statements that have a correct syntactic structure and seem to be sound and meaningful on first reading but are actually vacuous. Participants (N = 196; obtained via Amazon Mechanical Turk) rated the profoundness of bullshit statements (using the BSR) and provided favorability ratings of three Democratic (Hillary Clinton, Martin O'Malley, and Bernie Sanders) and three Republican candidates for US president (Ted Cruz, Marco Rubio, and Donald Trump). Participants also completed a measure of political liberalism/conservatism. Results revealed that favorable views of all three Republican candidates were positively related to judging bullshit statements as profound. The smallest correlation was found for Donald Trump. Although we observe a positive association between bullshit and support for the three Democrat candidates, this relationship is both substantively small and statistically insignificant. The general measure of political liberalism/conservatism was also related to judging bullshit statements as profound in that individuals who were more politically conservative had a higher tendency to see profoundness in bullshit statements. Of note, these results were not due to a general tendency among conservatives to see profoundness in everything: Favorable views of Republican candidates and conservatism were not significantly related to profoundness ratings of mundane statements. In contrast, this was the case for Hillary Clinton and Martin O'Malley. Overall, small

Profound bradycardia associated with NIV removal.

Science.gov (United States)

Echevarria, C; Bourke, S C; Gibson, G J

2012-01-01

A patient with lower-limb onset ALS presented with a one-month history of vasovagal episodes and a one-week history of cough productive of green sputum and lethargy. She was drowsy and in acute on chronic type-two respiratory failure. She responded to non-invasive ventilation, however she suffered recurrent episodes of profound bradycardia on removal of the mask, which gradually resolved over ten days. We have reviewed the literature and offer a potential explanation for these events.

Teaching Individuals with Profound Multiple Disabilities to Access Preferred Stimuli with Multiple Microswitches

Science.gov (United States)

Tam, Gee May; Phillips, Katrina J.; Mudford, Oliver C.

2011-01-01

We replicated and extended previous research on microswitch facilitated choice making by individuals with profound multiple disabilities. Following an assessment of stimulus preferences, we taught 6 adults with profound multiple disabilities to emit 2 different responses to activate highly preferred stimuli. All participants learnt to activate…

Weltanschauung und Politik in den heutigen USA. Barack Obama und der „neue Kulturkampf“ um die Führung der anglo-amerikanischen Weltmacht

Directory of Open Access Journals (Sweden)

Roland Benedikter

2010-06-01

Full Text Available The relationship between Worldviews and Politics in the USA today. Barack Obama and the “new cultural battle” for political supremacy in the US English Summary: This article provides an analysis of the current relationship between Politics, Culture and Worldviews in the USA under Barack Obama. The present “great Obama divide” of US domestic politics consists in the division between institutional and contextual (cultural and worldview politics. Obama has induced their current opposition when he ran for the US Presidency by profiling himself as a “cultural” candidate “against the system”. One result is that by becoming part of the system after being elected, Obama has lost some of his initial “revolutionary” appeal; a second effect is that the opposition is now trying to turn the tables by mobilizing the contextual political sphere against Obama’s control of the institutional power. In fact, the Republicans, rather than concentrating on traditional ways of regaining power focus on launching a new “worldview” battle against Obama in the hope to use the pre-political sphere to eventually regain the institutional political majority. The overall result is a general climate of “worldview mobilization” in the USA, and an increased influence of cultural and worldview philosophies onto the institutionalized mechanisms of politics. Pre-political movements like the conservative “inverting the myth – inverting the paradigm” movement or the “tea party” movement are the expression of attempts towards a new “cultural battle” for “the soul of the USA,” which has to be understood in its basic mechanisms, if the “Obama constellation” shall be understood. This article sketches some core elements of Obama’s worldview that are in play in this game, and it argues that many actions of Obama on the field of foreign politics are (and will be to a noticeable extent co-oriented toward influencing the domestic �

A Replication to Increase Happiness Indices among Some People with Profound Multiple Disabilities.

Science.gov (United States)

Ivancic, Martin T.; And Others

1997-01-01

The happiness indices in a Fun Time activity were systematically increased for three of four people with profound multiple disabilities by providing their preferred stimuli. The fourth showed decreased unhappiness. However, three people with profound disabilities and minimal movement failed to show any indices of happiness or unhappiness.…

Do colors exist? and other profound physics questions

CERN Document Server

Cottrell, Seth Stannard

2018-01-01

Why do polished stones look wet? How does the Twin Paradox work? Why are orbits ellipses? How can we be sure that pi never repeats? How does a quantum computer break encryption? Discover the answers to these, and other profound physics questions! This fascinating book presents a collection of articles based on conversations and correspondences between the author and complete strangers about physics and math. The author, a researcher in mathematical physics, responds to dozens of questions posed by inquiring minds from all over the world, ranging from the everyday to the profound. Rather than unnecessarily complex explanations mired in mysterious terminology and symbols, the reader is presented with the reasoning, experiments, and mathematics in a casual, conversational, and often comical style. Neither over-simplified nor over-technical, the lucid and entertaining writing will guide the reader from the each innocent question to a better understanding of the weird and beautiful universe around us. Advance prai...

Pre-Language Activities for the Profoundly Mentally Retarded.

Science.gov (United States)

Poole, Marilyn R.; And Others

Provided are sample lesson plans for a program to develop pre-language skills in profoundly retarded children and adults. Characteristic of the suggested activities is the stimulation of all sensory channels through structured infant-like play activities in five general areas: oral stimulation, sensory arousal, motor stimulation, vocal play, and…

25 CFR 170.407 - What happens to unobligated planning funds?

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What happens to unobligated planning funds? 170.407... RESERVATION ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Transportation Planning § 170.407 What happens to unobligated planning funds? Once all tribal governments...

President Barack Obama addresses the 146th annual meeting of the National Academy of Sciences.

Science.gov (United States)

2009-06-16

On April 27, 2009, President Barack Obama addressed members of the National Academy of Sciences (NAS) gathered at its 146th annual meeting in Washington, D.C. In his speech, the president shared his plans to give science and technology a central role in the nation's future and an immediate place in America's economic renewal. He outlined steps he is taking to increase research spending, achieve energy independence, and improve science education. Included was what Mr. Obama cited as the largest commitment to scientific research in American history-devoting more than 3% of our gross domestic product to research and development. "Next, we are restoring science to its rightful place," Mr. Obama told a packed NAS auditorium audience. "Under my administration, the days of science taking a backseat to ideology are over." He appealed to scientists' sense of personal responsibility to reach and educate young Americans: "I want to challenge you to use your love and knowledge of science to spark a sense of wonder and excitement in a new generation." President Obama was welcomed to the National Academy of Sciences by President Ralph J. Cicerone and John P. Holdren, Assistant to the President for Science and Technology and Director of the White House Office of Science and Technology Policy. The following is a transcript of that speech.

Music Training for Severely and Profoundly Retarded Individuals.

Science.gov (United States)

Kesler, Buford; Richmond, Bert O.

Investigated were the effects of sex, ability and training method on the musical instrument playing ability of 16 institutionalized severely and profoundly retarded persons ages 7 to 20 years. Ss were randomly assigned to one of four treatment groups, and the time required to reach criterion playing a familiar tune was recorded. Data indicated…

Self-Concept of Severely to Profoundly Hearing-Impaired Children.

Science.gov (United States)

Warren, Charlotte; Hasenstab, Suzanne

1986-01-01

A study examined demographic, impairment-related, and parental variables that best predicted self-concept among 49 severely to profoundly hearing-impaired 5- to 11-year-olds. A strong relationship was observed between self-concept and parental indulgence, parental rejection, parental protection, parental discipline, and extent of language…

What Just Happened to Me?

Science.gov (United States)

Peters, Dane L.

2012-01-01

The highly publicized story of unfathomable abuse by Penn State football coach Jerry Sandusky, as well the unfathomable response of those with the power to stop it, makes it clear that abuse can happen anywhere--and that adults need to be vigilant and educated. All of those who oversee schools must also ensure that their faculty and staff are well…

Communication dated 2 April 2009 received from the Permanent Missions of the Russian Federation and the United States of America regarding a joint statement by Russian President Dmitry Medvedev and U.S. President Barack Obama

International Nuclear Information System (INIS)

2009-01-01

The Secretariat has received a communication dated 2 April 2009 from the Permanent Missions of the Russian Federation and the United States of America, transmitting to the attention of all Member States of the IAEA a joint statement by Russian President Dmitry Medvedev and U.S. President Barack Obama issued on 1 April 2009. As requested in that communication, the attached statement is herewith circulated for the information of all Member States

Remembering President Barack Obama's inauguration and the landing of US Airways Flight 1549: A comparison of the predictors of autobiographical and event memory

DEFF Research Database (Denmark)

Koppel, Jonathan Mark; Brown, Adam D.; Stone, Charles B.

2013-01-01

regressions we found that the psychological variables of recalled emotional intensity and personal importance/centrality predicted AM consistency and event memory accuracy for the inauguration. Conversely, the rehearsal variables of covert rehearsal and media attention predicted, respectively, AM consistency......We examined and compared the predictors of autobiographical memory (AM) consistency and event memory accuracy across two publicly documented yet disparate public events: the inauguration of Barack Obama as the 44th president of the United States on January 20th 2009, and the emergency landing of US...... Airways Flight 1549, off the coast of Manhattan, on January 15th 2009. We tracked autobiographical and event memories for both events, with assessments taking place within 2½ weeks of both events (Survey 1), and again between 3½ and 4 months after both events (Survey 2). In a series of stepwise...

DMPD: Gram-negative endotoxin: an extraordinary lipid with profound effects oneukaryotic signal transduction. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 1916089 Gram-negative endotoxin: an extraordinary lipid with profound effects oneuk...ep;5(12):2652-60. (.png) (.svg) (.html) (.csml) Show Gram-negative endotoxin: an extraordinary lipid with profound effects...tive endotoxin: an extraordinary lipid with profound effects oneukaryotic signal transduction. Authors Raetz

Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation

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Anna R. Chambers

2016-08-01

Full Text Available Neurons at higher stages of sensory processing can partially compensate for a sudden drop in input from the periphery through a homeostatic plasticity process that increases the gain on weak afferent inputs. Even after a profound unilateral auditory neuropathy where > 95% of synapses between auditory nerve fibers and inner hair cells have been eliminated with ouabain, central gain can restore the cortical processing and perceptual detection of basic sounds delivered to the denervated ear. In this model of profound auditory neuropathy, cortical processing and perception recover despite the absence of an auditory brainstem response (ABR or brainstem acoustic reflexes, and only a partial recovery of sound processing at the level of the inferior colliculus (IC, an auditory midbrain nucleus. In this study, we induced a profound cochlear neuropathy with ouabain and asked whether central gain enabled a compensatory plasticity in the auditory thalamus comparable to the full recovery of function previously observed in the auditory cortex (ACtx, the partial recovery observed in the IC, or something different entirely. Unilateral ouabain treatment in adult mice effectively eliminated the ABR, yet robust sound-evoked activity persisted in a minority of units recorded from the contralateral medial geniculate body (MGB of awake mice. Sound-driven MGB units could decode moderate and high-intensity sounds with accuracies comparable to sham-treated control mice, but low-intensity classification was near chance. Pure tone receptive fields and synchronization to broadband pulse trains also persisted, albeit with significantly reduced quality and precision, respectively. MGB decoding of temporally modulated pulse trains and speech tokens were both greatly impaired in ouabain-treated mice. Taken together, the absence of an ABR belied a persistent auditory processing at the level of the MGB that was likely enabled through increased central gain. Compensatory

Epidemiology of fractures in people with severe and profound developmental disabilities

Science.gov (United States)

Glick, N.R.; Fischer, M.H.; Heisey, D.M.; Leverson, G.E.; Mann, D.C.

2005-01-01

Fractures are more prevalent among people with severe and profound developmental disabilities than in the general population. In order to characterize the tendency of these people to fracture, and to identify features that may guide the development of preventive strategies, we analyzed fracture epidemiology in people with severe and profound developmental disabilities who lived in a stable environment. Data from a 23-year longitudinal cohort registry of 1434 people with severe and profound developmental disabilities were analyzed to determine the effects of age, gender, mobility, bone fractured, month of fracture, and fracture history upon fracture rates. Eighty-five percent of all fractures involved the extremities. The overall fracture rate increased as mobility increased. In contrast, femoral shaft fracture risk was substantially higher in the least mobile [relative risk (RR), 10.36; 95% confidence interval (CI), 3.29-32.66] compared with the most mobile group. Although the overall fracture rate was not associated with age, the femoral shaft fractures decreased but hand/foot fractures increased with age. Overall fracture risk declined in August and September (RR, 0.70; 95% CI, 0.55-0.89), being especially prominent for tibial/fibular fractures (RR, 0.31; 95% CI, 0.13-0.70). Gender was not a factor in fracture risk. Two primary fracture mechanisms are apparent: one, largely associated with lack of weight-bearing in people with the least mobility, is exemplified by femoral fractures during non-traumatic events as simple as diapering or transfers; the other, probably due to movement- or fall-related trauma, is exemplified by hand/foot fractures in people who ambulate. The fracture experience of people with severe and profound developmental disabilities is unique and, because it differs qualitatively from postmenopausal osteoporosis, may require population-specific methods for assessing risk, for improving bone integrity, and for reduction of falls and accidents

Reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia: sugammadex versus neostigmine.

Directory of Open Access Journals (Sweden)

Lemmens Hendrikus JM

2010-09-01

Full Text Available Abstract Background Acetylcholinesterase inhibitors cannot rapidly reverse profound neuromuscular block. Sugammadex, a selective relaxant binding agent, reverses the effects of rocuronium and vecuronium by encapsulation. This study assessed the efficacy of sugammadex compared with neostigmine in reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia. Methods Patients aged ≥18 years, American Society of Anesthesiologists class 1-4, scheduled to undergo surgery under general anesthesia were enrolled in this phase III, multicenter, randomized, safety-assessor blinded study. Sevoflurane anesthetized patients received vecuronium 0.1 mg/kg for intubation, with maintenance doses of 0.015 mg/kg as required. Patients were randomized to receive sugammadex 4 mg/kg or neostigmine 70 μg/kg with glycopyrrolate 14 μg/kg at 1-2 post-tetanic counts. The primary efficacy variable was time from start of study drug administration to recovery of the train-of-four ratio to 0.9. Safety assessments included physical examination, laboratory data, vital signs, and adverse events. Results Eighty three patients were included in the intent-to-treat population (sugammadex, n = 47; neostigmine, n = 36. Geometric mean time to recovery of the train-of-four ratio to 0.9 was 15-fold faster with sugammadex (4.5 minutes compared with neostigmine (66.2 minutes; p Conclusions Recovery from profound vecuronium-induced block is significantly faster with sugammadex, compared with neostigmine. Neostigmine did not rapidly reverse profound neuromuscular block (Trial registration number: NCT00473694.

30 CFR 285.224 - What happens if MMS accepts my bid?

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What happens if MMS accepts my bid? 285.224... Renewable Energy Leases Competitive Lease Award Process § 285.224 What happens if MMS accepts my bid? If we... withdraw an OCS area in which we have held a lease sale before you and MMS execute the lease in that area...

A Prognostic Model for Development of Profound Shock among Children Presenting with Dengue Shock Syndrome.

Directory of Open Access Journals (Sweden)

Phung Khanh Lam

Full Text Available To identify risk factors and develop a prediction model for the development of profound and recurrent shock amongst children presenting with dengue shock syndrome (DSS.We analyzed data from a prospective cohort of children with DSS recruited at the Paediatric Intensive Care Unit of the Hospital for Tropical Disease in Ho Chi Minh City, Vietnam. The primary endpoint was "profound DSS", defined as ≥2 recurrent shock episodes (for subjects presenting in compensated shock, or ≥1 recurrent shock episodes (for subjects presenting initially with decompensated/hypotensive shock, and/or requirement for inotropic support. Recurrent shock was evaluated as a secondary endpoint. Risk factors were pre-defined clinical and laboratory variables collected at the time of presentation with shock. Prognostic model development was based on logistic regression and compared to several alternative approaches.The analysis population included 1207 children of whom 222 (18% progressed to "profound DSS" and 433 (36% had recurrent shock. Independent risk factors for both endpoints included younger age, earlier presentation, higher pulse rate, higher temperature, higher haematocrit and, for females, worse hemodynamic status at presentation. The final prognostic model for "profound DSS" showed acceptable discrimination (AUC=0.69 for internal validation and calibration and is presented as a simple score-chart.Several risk factors for development of profound or recurrent shock among children presenting with DSS were identified. The score-chart derived from the prognostic models should improve triage and management of children presenting with DSS in dengue-endemic areas.

Factors which Motivate Job Acceptance and Profoundly Mentally Retarded Children.

Science.gov (United States)

Marozas, Donald S.; May, Deborah C.

1980-01-01

The study involving 360 Pennsylvania teachers was designed to identify factors which motivate job acceptance among teachers of severely and profoundly mentally retarded children. The responses of 235 teachers indicated that challenge and practicum experiences were the two most prevalent motivational factors underlying job acceptance. (Author)

Why the Singularity Cannot Happen

OpenAIRE

Modis, Theodore

2012-01-01

The concept of a Singularity as described in Ray Kurzweil's book cannot happen for a number of reasons. One reason is that all natural growth processes that follow exponential patterns eventually reveal themselves to be following S-curves thus excluding runaway situations. The remaining growth potential from Kurzweil's ''knee'', which could be approximated as the moment when an S-curve pattern begins deviating from the corresponding exponential, is a factor of only one order of magnitude grea...

49 CFR 385.319 - What happens after completion of the safety audit?

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false What happens after completion of the safety audit... REGULATIONS SAFETY FITNESS PROCEDURES New Entrant Safety Assurance Program § 385.319 What happens after completion of the safety audit? (a) Upon completion of the safety audit, the auditor will review the findings...

Bipolar Affective Disorder in a Patient of Profound Deafness.

Science.gov (United States)

Zubair, Usama Bin; Mumtaz, Humza; Mansoor, Sawera

2018-03-01

Profound deafness is a lifelong impairment, leading to the physical disability as well as poor psychological adjustment. We herein present a mental health disorder rarely seen among the patients of profound deafness. A 16-year deaf and dumb girl, previously treated for depression, presented with unusual laughter, irritability, flight of ideas, decreased sleep, ideas of self importance, and decreased social functioning and educational performance. These problems were understood by the parents via sign language, who interpreted them to the interviewer. Her Young Mania Rating Scale (YMRS) score was 19 and Brief Psychiatric Rating Scale (BPRS) score was 52. She was diagnosed as a case of bipolar affective disorder (BPAD). Marked improvement in the symptoms and social and educational performance was noted after two weeks of the treatment with sodium valproate, resperidone and clonazepam. Treatment options were explained to the patient with risks and benefits, and she was involved in the decision-making. This case report highlights the importance of accurately diagnosing and managing a rare mental health disorder among the physically handicapped people, especially those who cannot communicate effectively and explain their unusual subjective experiences.

A Grounded Theory of Effective Reading by Profoundly Deaf Adults

Science.gov (United States)

Silvestri, Julia; Wang, Ye

2018-01-01

The purpose of the study was to uncover and describe psycholinguistic and sociocognitive factors facilitating effective reading by signing adults who are profoundly deaf and do not use hearing technology. The sample comprised four groups, each consisting of 15 adults, for a total of 60 participants. The four groups were "deaf…

Deming's System of Profound Knowledge: An Overview for International Educators.

Science.gov (United States)

Evans, Thomas J.

W. Edwards Deming called for the transformation to a new style of organizational management based on greater cooperation between managers and employees. This transformation could be achieved by introducing "profound knowledge" into the system. This paper is a presentation outline that was used to introduce the basics of Deming's theory…

Asystole Following Profound Vagal Stimulation During Hepatectomy

Directory of Open Access Journals (Sweden)

Preeta John

2008-01-01

Full Text Available Asystole in a non laparoscopic upper abdominal surgery following intense vagal stimulation is a rare event. This case report highlights the need for awareness of such a complication when a thoracic epidural anaesthetic has been given in addition to a general anaesthetic for an upper abdominal procedure. A combined thoracic epidural and general anaesthetic was given. The anterior abdominal wall was retracted forty minutes after administration of the epidural bolus. This maneuver resulted in a profound vagal response with bradycardia and asystole. The patient was resuscitated successfully with a cardiac massage, atropine and adrenaline and the surgery was resumed. Surgery lasted eleven hours and was uneventful.

Acceleration of Object Permanence with Severely and Profoundly Retarded Children.

Science.gov (United States)

Kahn, James V.

Examined was the effectiveness of training four severely and profoundly retarded children (3-6 years old) to improve their level of functioning on a measure of object permanence and to demonstrate generalization to other areas of sensorimotor intelligence. Ss were given a pretest and posttest on the I. Uzgiris and J. Hunt instrument which consists…

Oral Communication Development in Severe to Profound Hearing Impaired Children After Receiving Aural Habilitation

Directory of Open Access Journals (Sweden)

Soleimani Farin

2009-10-01

Full Text Available Communication, cognition, language, and speech are interrelated and develop together. It should come as no surprise to us that the key to intervention with deaf children is to establish, as early as possible, a functional communication system for the child and the parents. Early intervention programs need to be multidisciplinary, technologically sound and most important, it should take cognizance of the specific context (community, country in which the child and family function. The main aim of this study was to obtain oral communication development regarding current status of the intervention (aural habilitation and speech therapyfor children with severe to profound hearing impairment in Iran. A prospective longitudinal study was undertaken on a consecutive group of children with severe to profound deafness. Nine severe to profound hearing-impaired children out of the primer 42 cases, who were detected below two years old, had been selected in the previous study to receive aural habilitation. The average of their speech intelligibility scores was near 70% at age 6, which was accounted as poor oral communication and only two of them were able to communicate by spoken language. An integrated intervention services continued again for one year and their oral communication skill was assessed by their speech intelligibility. The intelligibility test of children was recorded on audio-tape, when they read 10 questions such as where is your home. This can be answered only in one word. Each tape was presented to10 normal hearing listeners, and their task was to write down, the answers in Persian orthography. At the beginning (at age 6 the average speech intelligibility score of these children was 72% and only two of them had score of 90% and 100%. At age 7, all of the severe groups were over 90%, and only two profound ones achieved the score of 48% and 62%. All of severe groups develop oral communication, but profound ones had a semi-intelligible speech

40 CFR 60.2685 - What happens during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... happens during periods of startup, shutdown, and malfunction? (a) The emission limitations and operating limits apply at all times except during CISWI unit startups, shutdowns, or malfunctions. (b) Each...

12 CFR 563b.435 - What happens to my corporate existence after conversion?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What happens to my corporate existence after... What happens to my corporate existence after conversion? Your corporate existence will continue following your conversion, unless you convert to a state-chartered stock savings association and state law...

What makes microfinance happen?

Directory of Open Access Journals (Sweden)

Manuel Antonio Jiménez Castillo

2015-12-01

Full Text Available In this paper we have attempted to shed light on what makes development happen from those determinants that enable microfinance work as an effective tool to eradicate poverty. The effectiveness of such instrument in the generation of wealth to the poorest class demand overcoming the minimalist approach that condemns its practices to a mere provision of microfinancial services. This hypothesis will be analytically and empirically proven assuming human development as a cause and not only as an outcome of the microfinance success. To such end, two regression lines were designed where variables such as education, health and food security proved to be explanatory determinant to explain income behaviour for those beneficiaries of the microfinance programs.

40 CFR 62.14645 - What happens during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 8 2010-07-01 2010-07-01 false What happens during periods of startup... Limits § 62.14645 What happens during periods of startup, shutdown, and malfunction? (a) The emission limitations and operating limits apply at all times except during periods of CISWI unit startup, shutdown, or...

40 CFR 60.2120 - What happens during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... 1, 2001 Emission Limitations and Operating Limits § 60.2120 What happens during periods of startup... during CISWI unit startups, shutdowns, or malfunctions. (b) Each malfunction must last no longer than 3...

40 CFR 141.561 - What happens if my system's turbidity monitoring equipment fails?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 22 2010-07-01 2010-07-01 false What happens if my system's turbidity... Disinfection-Systems Serving Fewer Than 10,000 People Individual Filter Turbidity Requirements § 141.561 What happens if my system's turbidity monitoring equipment fails? If there is a failure in the continuous...

What Happens When You Flip a Switch?

Science.gov (United States)

Darling, Gerald

2013-01-01

Although energy is fundamental to our civilization, few high school students have a clear picture of what happens when they use it. To become informed citizens and decision makers, every high school student must understand how we generate electrical energy. Working through the series of inexpensive, hands-on activities presented in this article,…

Prevalence of Auditory Neuropathy in a Population of Children with Severe to Profound Hearing Loss

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Nader Saki

2013-04-01

Full Text Available Background: The purpose of this investigation is to determine auditory neuropathy in the students with severe to profound hearing losses in Ahwaz.Materials and Methods: In this cross-sectional study, 212 children of 7-11 year old with severe to profound hearing loss performed ordinary audiometric evaluations as well as ABR and OAE. The patients with normal DPOAE who had no record of acoustic reflex having normal ABR, were considered as the patients with auditory neuropathy. Results: The neuropathic complication found in 14 children was appeared in 8 ones as one-sided (57.14% and in 6 ones (42.86% as two-sided. 68% of the patients as diagnosed had a very low Speech Discrimination Score (SDS.Conclusion: we must be very vigilant in auditory neuropathy diagnosis for the purpose to be successful in appropriate treatment of severe to profound hearing losses.

Static and Dynamic Balance in Congenital Severe to Profound Hearing-Impaired Children

Directory of Open Access Journals (Sweden)

Farideh HajiHeydari

2011-09-01

Full Text Available Background and Aim: Research conducted since the early 1900s has consistently identified differences between deaf and hearing children on performance of a wide variety of motor tasks, most notably balance. Our study was performed to test static and dynamic balance skills in congenital severe to profound hearing impaired children in comparison with normal age-matched children.Methods: This cross-sectional study was conducted on 30 severe to profound hearing impaired and 40 normal children with age 6 to 10 years old. Bruininks-Oseretsky test of motor proficiency 2, balance subset with 9 parts was used for evaluation of balance skills.Results: Hearing-impaired children showed 16.7 to 100% fail results in 7 parts of the balance subset. In normal children fail result was revealed just in 3 parts of the balance subset from 2.5 to 57.5%, and differences between two groups were significant (p<0.0001. There was a significant difference between two groups in two static balance skills of standing on one leg on a line and standing on one leg on a balance beam with eyes closed (p<0.0001.conclusion: It seems that development of static balance skills are longer than dynamic ones. Because severe to profound hearing-impaired children showed more weakness than normal children in both static and dynamic balance abilities, functional tests of balance proficiency can help to identify balance disorders in these children.

Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys.

NARCIS (Netherlands)

Boer, H.D. de; Egmond, J. van; Pol, F. van de; Bom, A.; Booij, L.H.D.J.

2006-01-01

BACKGROUND: Reversal of neuromuscular blockade can be accomplished by chemical encapsulation of rocuronium by sugammadex, a synthetic gamma-cyclodextrin derivative. The current study determined the feasibility of reversal of rocuronium-induced profound neuromuscular blockade with sugammadex in the

Connections that Count: Brain-Computer Interface Enables the Profoundly Paralyzed to Communicate

Science.gov (United States)

... Home Current Issue Past Issues Connections that Count: Brain-Computer Interface Enables the Profoundly Paralyzed to Communicate Past Issues / ... of this page please turn Javascript on. A brain-computer interface (BCI) system This brain-computer interface (BCI) system ...

Noonan Syndrome: An Underestimated Cause of Severe to Profound Sensorineural Hearing Impairment. Which Clues to Suspect the Diagnosis?

Science.gov (United States)

Ziegler, Alban; Loundon, Natalie; Jonard, Laurence; Cavé, Hélène; Baujat, Geneviève; Gherbi, Souad; Couloigner, Vincent; Marlin, Sandrine

2017-09-01

To highlight Noonan syndrome as a clinically recognizable cause of severe to profound sensorineural hearing impairment. New clinical cases and review. Patients evaluated for etiological diagnosis by a medical geneticist in a reference center for hearing impairment. Five patients presenting with confirmed Noonan syndrome and profound sensorineural hearing impairment. Diagnostic and review of the literature. Five patients presented with profound sensorineural hearing impairment and molecularly confirmed Noonan syndrome. Sensorineural hearing impairment has been progressive for three patients. Cardiac echography identified pulmonary stenosis in two patients and was normal for the three other patients. Short stature was found in two patients. Mild intellectual disability was found in one patient. Inconspicuous clinical features as facial dysmorphism, cryptorchidism, or easy bruising were of peculiar interest to reach the diagnosis of Noonan syndrome. Profound sensorineural hearing impairment can be the main feature of Noonan syndrome. Associated features are highly variable; thus, detailed medical history and careful physical examination are mandatory to consider the diagnosis in case of a sensorineural hearing impairment.

Profound vision loss impairs psychological well-being in young and middle-aged individuals.

Science.gov (United States)

Garcia, Giancarlo A; Khoshnevis, Matin; Gale, Jesse; Frousiakis, Starleen E; Hwang, Tiffany J; Poincenot, Lissa; Karanjia, Rustum; Baron, David; Sadun, Alfredo A

2017-01-01

The aim of this study was to evaluate the effects of profound vision loss on psychological well-being in adolescents, young adults, and middle-aged adults with regard to mood, interpersonal interactions, and career-related goals. In addition, we assessed the significance of the resources that may be used to enhance psychological well-being in cases of profound vision loss, and in particular, examined the utility of low vision aids and the role of the ophthalmologist as a provider of emotional support. A questionnaire was issued to individuals aged 13-65 years with profound vision loss resulting from Leber's hereditary optic neuropathy (LHON). Depression prevalence was evaluated with questions regarding major depressive disorder symptomatology. Participants appraised the effects of vision loss on their interpersonal interactions and career goals by providing an impact rating (IR) on a 21-point psychometric scale from -10 to +10. Social well-being index was defined as the average of interpersonal IR and career IR. Subjects were additionally asked about the use of low vision aids and sources of emotional support. A total of 103 participants (mean age =26.4±11.2 years at LHON diagnosis; mean ± standard deviation) completed the questionnaire. Nearly half (49.5%) met the depression criteria after vision loss. Negative impacts on interpersonal interactions (median IR = -5) and career goals (median IR = -6) were observed; both ratings were worse ( P negative interpersonal IR and career IR. Sixty-eight percent of subjects used electronic vision aids; controlling for age, social well-being index was higher among these individuals than for those who did not use electronic aids ( P =0.03). Over half of the participants (52.4%) asserted that they derived emotional support from their ophthalmologist. Profound vision loss in adolescents, young adults, and middle-aged adults is associated with significant negative psychological and psychosocial effects, which are influenced by

SJIT Happens og ungdoms-tv

DEFF Research Database (Denmark)

Hansen, Kim Toft

2018-01-01

for kernemålgruppen. Kapitlet indeholder en diskussion af tilgangene enkeltprogramanalyse og programfladeanalyse i forhold til overgangen fra flow-tv til streaming-tjenesternes vækst. Det er dette kapitels hovedpointe, at særligt en series iscenesættelse fungerer som en repræsentation af kernepublikummet, og kapitlet......I kapitlet "SJIT Happens og ungdoms-tv" tager jeg udgangspunkt i, at unge seere i aldersgruppen 12-34 har flyttet sig fra traditionelt lineært tv til online mediebrug siden 2010. Dette udgangspunkt fører til to vinkler: en institutionsanalytisk redegørelse for TV 2’s ungdomskanal ZULU og en analyse...

40 CFR 1045.415 - What happens if in-use engines do not meet requirements?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What happens if in-use engines do not... VESSELS In-Use Testing § 1045.415 What happens if in-use engines do not meet requirements? (a) Determine... families showing that you designed them to exceed the minimum requirements for controlling emissions. We...

40 CFR 1048.415 - What happens if in-use engines do not meet requirements?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What happens if in-use engines do not... Testing In-use Engines § 1048.415 What happens if in-use engines do not meet requirements? (a) Determine... families showing that you designed them to exceed the minimum requirements for controlling emissions. We...

The impact of visual impairment on the ability to perform activities of daily living for persons with severe/profound intellectual disability.

Science.gov (United States)

Dijkhuizen, Annemarie; Hilgenkamp, Thessa I M; Krijnen, Wim P; van der Schans, Cees P; Waninge, Aly

2016-01-01

The ability to perform activities of daily living (ADL) as a component of participation is one of the factors that contribute to quality of life. The ability to perform ADL for persons experiencing severe/profound intellectual disability (ID) may be reduced due to their cognitive and physical capacities. However, until recently, the impact of the significantly prevalent visual impairments on the performance of activities of daily living has not yet been revealed within this group. The purpose of this prospective cross-sectional study was to investigate the impact of visual impairment on the performance of activities of daily living for persons with a severe/profound intellectual disability. The Barthel Index (BI) and Comfortable Walking Speed (CWS) were used to measure the ability of performing activities of daily living (ADL) in 240 persons with severe/profound ID and having Gross Motor Functioning Classification System (GMFCS) levels I, II or III; this included 120 persons with visual impairment. The impact of visual impairment on ADL was analyzed with linear regression. The results of the study demonstrated that visual impairment slightly affects the ability of performing activities of daily living (BI) for persons experiencing a severe/profound intellectual disability. GMFCS Levels II or III, profound ID level, and visual impairment each have the effect of lowering BI scores. GMFCS Levels II or III, and profound ID level each have the effect of increasing CWS scores, which indicates a lower walking speed. A main effect of visual impairment is present on CWS, but our results do show a substantive interaction effect between GMFCS level III and visual impairment on Comfortable Walking Speed in persons with a severe/profound intellectual disability. Visual impairment has a slight effect on ability to perform ADL in persons experiencing severe/profound ID. Copyright © 2015 Elsevier Ltd. All rights reserved.

Attuning: A Communication Process between People with Severe and Profound Intellectual Disability and Their Interaction Partners.

Science.gov (United States)

Griffiths, Colin; Smith, Martine

2016-03-01

People with severe and profound intellectual disability typically demonstrate a limited ability to communicate effectively. Most of their communications are non-verbal, often idiosyncratic and ambiguous. This article aims to identify the process that regulates communications of this group of people with others and to describe the methodological approach that was used to achieve this. In this qualitative study, two dyads consisting of a person with severe or profound intellectual and multiple disability and a teacher or carer were filmed as they engaged in school-based activities. Two 1-hour videotapes were transcribed and analysed using grounded theory. Attuning was identified within the theory proposed here as a central process that calibrates and regulates communication. Attuning is conceptualized as a bidirectional, dyadic communication process. Understanding this process may support more effective communication between people with severe or profound intellectual and multiple disability and their interaction partners. © 2015 John Wiley & Sons Ltd.

Could a 'Chernobyl' nuclear disaster happen here?

International Nuclear Information System (INIS)

Van Heerden, A.

1986-01-01

At 1.23 a.m. (Soviet European Time) on Saturday 26 April 1986 an accident occurred in reactor number four of the Chernobyl Nuclear Power-Station in the Ukrainian Soviet Socialist Republic. The hydrogen in the core of the reactor exploded while the reactor was being shut down for routine maintenance, and a cloud of radioactivity was blasted high into the atmosphere. The radioactive plume drifted north-westwards to Sweden where, on 28 April, a radiation detector at the Forsmark nuclear complex gave the first public warning of the Chernobyl disaster. South Africa possesses one nuclear power-station, at Koeberg some 30 kilometres north of Cape Town. Is Koeberg safe? Could a Chernobyl-style disaster occur here? The difference in design between the Chernobylsk-4 reactor and Koeberg reactor is discussed. Differences in the design of the two power-stations preclude the same type of accident from happening at Koeberg. The chances of an accident affecting the environment seriously remain remote, given a design philosophy which includes minimising the possibility of an accident, containing it should it happen, and pre-planning the emergency response in case it cannot be contained. That, in a nutshell, is why we believe Koeberg will never become a 'Chernobyl'

Profound hyper natremia due to central diabetes insipidus

International Nuclear Information System (INIS)

Vaqar, A.; Javaid, K.H.; Parveen, R.; Sadaf, R.

2012-01-01

Diabetes insipidus is a rare endocrine disorder in paediatric patients. Polyuria is a cardinal manifestation that is extremely difficult to recognize in diapered infants. Careful urine quantification is the key to diagnosis in appropriate clinical setting. We report a case of a 4 months old infant presenting with an acute life threatening event following an episode of vomiting and decreased oral intake. She had profound hyper natremia which persisted after stabilization. Polyuria unrecognized by the mother was revealed by 24-hour urine output measurement. A diagnosis of diabetes insipidus was made after appropriate laboratory investigations including serum and urine osmolality. The central nature of the disease was confirmed by neuroimaging which showed holoprosencephaly. (author)

Profound microcephaly, primordial dwarfism with developmental brain malformations: a new syndrome.

Science.gov (United States)

Abdel-Salam, Ghada M H; Abdel-Hamid, Mohamed S; Saleem, Sahar N; Ahmed, Mahmoud K H; Issa, Mahmoud; Effat, Laila K; Kayed, Hisham F; Zaki, Maha S; Gaber, Khaled R

2012-08-01

We describe two sibs with a lethal form of profound congenital microcephaly, intrauterine and postnatal growth retardation, subtle skeletal changes, and poorly developed brain. The sibs had striking absent cranial vault with sloping of the forehead, large beaked nose, relatively large ears, and mandibular micro-retrognathia. Brain magnetic resonance imaging (MRI) revealed extremely simplified gyral pattern, large interhemispheric cyst and agenesis of corpus callosum, abnormally shaped hippocampus, and proportionately affected cerebellum and brainstem. In addition, fundus examination showed foveal hypoplasia with optic nerve atrophy. No abnormalities of the internal organs were found. This profound form of microcephaly was identified at 17 weeks gestation by ultrasound and fetal brain MRI helped in characterizing the developmental brain malformations in the second sib. Molecular analysis excluded mutations in potentially related genes such as RNU4ATAC, SLC25A19, and ASPM. These clinical and imaging findings are unlike that of any recognized severe forms of microcephaly which is believed to be a new microcephalic primordial dwarfism (MPD) with developmental brain malformations with most probably autosomal recessive inheritance based on consanguinity and similarly affected male and female sibs. Copyright © 2012 Wiley Periodicals, Inc.

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.

Science.gov (United States)

Mercimek-Mahmutoglu, Saadet; Horvath, Gabriella A; Coulter-Mackie, Marion; Nelson, Tanya; Waters, Paula J; Sargent, Michael; Struys, Eduard; Jakobs, Cornelis; Stockler-Ipsiroglu, Sylvia; Connolly, Mary B

2012-05-01

Pyridoxine-dependent epilepsy (PDE) was first described in 1954. The ALDH7A1 gene mutations resulting in α-aminoadipic semialdehyde dehydrogenase deficiency as a cause of PDE was identified only in 2005. Neonatal epileptic encephalopathy is the presenting feature in >50% of patients with classic PDE. We report the case of a 13-month-old girl with profound neonatal hypoglycemia (0.6 mmol/L; reference range >2.4), lactic acidosis (11 mmol/L; reference range A (p.Val278Val), and a novel putative pathogenic missense mutation c.1192G>C (p.Gly398Arg) in the ALDH7A1 gene. She has been seizure-free since 1.5 months of age on treatment with pyridoxine alone. She has motor delay and central hypotonia but normal language and social development at the age of 13 months. This case is the first description of a patient with PDE due to mutations in the ALDH7A1 gene who presented with profound neonatal hypoglycemia and lactic acidosis masquerading as a neonatal-onset gluconeogenesis defect. PDE should be included in the differential diagnosis of hypoglycemia and lactic acidosis in addition to medically refractory neonatal seizures.

Remembering President Barack Obama's inauguration and the landing of US Airways Flight 1549: a comparison of the predictors of autobiographical and event memory.

Science.gov (United States)

Koppel, Jonathan; Brown, Adam D; Stone, Charles B; Coman, Alin; Hirst, William

2013-01-01

We examined and compared the predictors of autobiographical memory (AM) consistency and event memory accuracy across two publicly documented yet disparate public events: the inauguration of Barack Obama as the 44th president of the United States on January 20th 2009, and the emergency landing of US Airways Flight 1549, off the coast of Manhattan, on January 15th 2009. We tracked autobiographical and event memories for both events, with assessments taking place within 2½ weeks of both events (Survey 1), and again between 3½ and 4 months after both events (Survey 2). In a series of stepwise regressions we found that the psychological variables of recalled emotional intensity and personal importance/centrality predicted AM consistency and event memory accuracy for the inauguration. Conversely, the rehearsal variables of covert rehearsal and media attention predicted, respectively, AM consistency and event memory accuracy for the plane landing. We conclude from these findings that different factors may underlie autobiographical and event memory for personally and culturally significant events (e.g., the inauguration), relative to noteworthy, yet less culturally significant, events (e.g., the plane landing).

43 CFR 30.128 - What happens if an error in BIA's estate inventory is alleged?

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What happens if an error in BIA's estate... INDIAN PROBATE HEARINGS PROCEDURES Judicial Authority and Duties § 30.128 What happens if an error in BIA's estate inventory is alleged? This section applies when, during a probate proceeding, an interested...

A Vibrotactile Interface to Motivate Movement for Children with Severe to Profound Disabilities

DEFF Research Database (Denmark)

Manresa-Yee, Cristina; Morrison, Ann; Larsen, Jeppe Veirum

2014-01-01

V-Sense is a vibrotactile interface that encourages children with severe or profound cognitive, sensory and physical impairments to move. The interface makes use of touch, in particular vibrations, as a supportive function to motivate users' actions. Specifically, we propose a vibrotactile...

Like cognitive function, decision making across the life span shows profound age-related changes.

Science.gov (United States)

Tymula, Agnieszka; Rosenberg Belmaker, Lior A; Ruderman, Lital; Glimcher, Paul W; Levy, Ifat

2013-10-15

It has long been known that human cognitive function improves through young adulthood and then declines across the later life span. Here we examined how decision-making function changes across the life span by measuring risk and ambiguity attitudes in the gain and loss domains, as well as choice consistency, in an urban cohort ranging in age from 12 to 90 y. We identified several important age-related patterns in decision making under uncertainty: First, we found that healthy elders between the ages of 65 and 90 were strikingly inconsistent in their choices compared with younger subjects. Just as elders show profound declines in cognitive function, they also show profound declines in choice rationality compared with their younger peers. Second, we found that the widely documented phenomenon of ambiguity aversion is specific to the gain domain and does not occur in the loss domain, except for a slight effect in older adults. Finally, extending an earlier report by our group, we found that risk attitudes across the life span show an inverted U-shaped function; both elders and adolescents are more risk-averse than their midlife counterparts. Taken together, these characterizations of decision-making function across the life span in this urban cohort strengthen the conclusions of previous reports suggesting a profound impact of aging on cognitive function in this domain.

Maturation of the mitochondrial redox response to profound asphyxia in fetal sheep.

Directory of Open Access Journals (Sweden)

Paul P Drury

Full Text Available Fetal susceptibility to hypoxic brain injury increases over the last third of gestation. This study examined the hypothesis that this is associated with impaired mitochondrial adaptation, as measured by more rapid oxidation of cytochrome oxidase (CytOx during profound asphyxia.Chronically instrumented fetal sheep at 0.6, 0.7, and 0.85 gestation were subjected to either 30 min (0.6 gestational age (ga, n = 6, 25 min (0.7 ga, n = 27 or 15 min (0.85 ga, n = 17 of complete umbilical cord occlusion. Fetal EEG, cerebral impedance (to measure brain swelling and near-infrared spectroscopy-derived intra-cerebral oxygenation (ΔHb = HbO(2 - Hb, total hemoglobin (THb and CytOx redox state were monitored continuously. Occlusion was associated with profound, rapid fall in ΔHb in all groups to a plateau from 6 min, greatest at 0.85 ga compared to 0.6 and 0.7 ga (p<0.05. THb initially increased at all ages, with the greatest rise at 0.85 ga (p<0.05, followed by a progressive fall from 7 min in all groups. CytOx initially increased in all groups with the greatest rise at 0.85 ga (p<0.05, followed by a further, delayed increase in preterm fetuses, but a striking fall in the 0.85 group after 6 min of occlusion. Cerebral impedance (a measure of cytotoxic edema increased earlier and more rapidly with greater gestation. In conclusion, the more rapid rise in CytOx and cortical impedance during profound asphyxia with greater maturation is consistent with increasing dependence on oxidative metabolism leading to earlier onset of neural energy failure before the onset of systemic hypotension.

The Influence of Phonological Mechanisms in Written Spelling of Profoundly Deaf Children

Science.gov (United States)

Colombo, Lucia; Arfe, Barbara; Bronte, Tiziana

2012-01-01

In the present study, the effect of phonological and working memory mechanisms involved in spelling Italian single words was explored in two groups of children matched for grade level: a group of normally hearing children and a group of pre-verbally deaf children, with severe-to-profound hearing loss. Three-syllable and four-syllable familiar…

Family matters: The experiences and opinions of family members of persons with (severe) or profound intellectual disabilities

OpenAIRE

Luijkx, Jorien

2016-01-01

“I love my sister, but sometimes I don’t”. This is one of the statements made in the study focused on the experiences of family members of people with (profound) intellectual (and multiple) disabilities (both of individuals living in a residential facility as persons living at home). In recent years, there has been greater recognition of the important position of parents and siblings of people with (profound) intellectual (and multiple) disabilities and the importance of the wellbeing of all ...

Reversal of rocuronium-induced profound neuromuscular block by sugammadex in Duchenne muscular dystrophy.

NARCIS (Netherlands)

Boer, H.D. de; Egmond, J. van; Booij, L.H.D.J.; Driessen, J.J.

2009-01-01

A case is reported in which a child with Duchenne muscular dystrophy received a dose of sugammadex to reverse a rocuronium-induced profound neuromuscular block. Sugammadex is the first selective relaxant binding agent and reverses rocuronium- and vecuronium-induced neuromuscular block. A fast and

29 CFR 37.84 - What happens if CRC does not have jurisdiction over a complaint?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true What happens if CRC does not have jurisdiction over a complaint? 37.84 Section 37.84 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE... Procedures § 37.84 What happens if CRC does not have jurisdiction over a complaint? If CRC does not have...

An Enduring Vision: The Melting Pot That Did Happen.

Science.gov (United States)

Portes, Alejandro

2000-01-01

Discusses the 1963 book, "Beyond the Melting Pot," which argued that the melting pot never happened and neither assimilation nor cultural pluralism occurred (at least in New York City). Concludes that this is a landmark book because it challenges the canonical assimilation story, provides a new set of standards for expert knowledge in…

30 CFR 203.66 - What happens if MMS does not act in the time allowed?

Science.gov (United States)

2010-07-01

... Relief for Pre-Act Deep Water Leases and for Development and Expansion Projects § 203.66 What happens if MMS does not act in the time allowed? If we do not act within the timeframes established under § 203... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What happens if MMS does not act in the time...

Classroom Procedures for the Measurement of Behavior State among Students with Profound Disabilities.

Science.gov (United States)

Guy, Barbara; And Others

1993-01-01

This study examined whether teacher-implemented classroom measurement procedures of short duration are as reliable as methods used in research studies to determine behavior state (e.g., awake active, awake inactive, asleep, drowsed) of six students with profound mental disabilities. Results indicated that more frequent but briefer measurements…

Operationalizing quality of life for people with profound multiple disabilities : a Delphi study

NARCIS (Netherlands)

Petry, K.; Maes, B.; Vlaskamp, C.

Background: In a recent study, we constructed an item pool that contains items on the quality of life (QOL) and related aspects of support of people with profound multiple disabilities (PMD). In the present study, a panel of experts assessed the content and the structure of this item pool in order

A Data Based Multidimensional Oral Hygiene Curriculum for the Severely and Profoundly Handicapped.

Science.gov (United States)

Feldman, David; Elliott, Thomas A.

A multidimensional oral hygiene curriculum appropriate for the moderately to profoundly retarded and composed of tooth brushing, flossing, and gum stimulation/massage is proposed. Task analyses are included for manual tooth brushing, utilizing an oral irrigation appliance, manual flossing, and use of an adaptive aid for flossing. Also provided are…

Validation of the Spanish version of the Baylor Profound Mental Status Examination.

Science.gov (United States)

Salmerón, Sergio; Huedo, Isabel; López-Utiel, Melisa; Soler-Moratalla, Isabel; Flores-Ruano, Teresa; Fernández-Sánchez, Miguel; Noguerón, Alicia; Doody, Rachelle S; Abizanda, Pedro

2016-01-01

There are no short valid instruments to evaluate cognitive status in severe Alzheimer's disease (AD) patients in the Spanish language. To validate the Spanish version of the Baylor Profound Mental Status Examination (BPMSE-Sp). The Baylor Profound Mental Status Examination (BPMSE) was translated to Spanish and back translated. Validation was conducted in 100 patients with severe probable AD with a Mini-Mental State Examination (MMSE) reliability. The mean age of patients was 84.9; 74% were female; 64% were institutionalized. The mean MMSE was 5.6; the mean BPMSE-Sp was 13.6; the mean BPMSE-Sp behavior was 1.2; the mean SIB was 42.2; and the mean NPI-Q was 4.7. BPMSE-Sp presented good internal consistency (Cronbach α= 0.84). There were significant correlations between the BPMSE-Sp and MMSE (r = 0.86, p reliability were in both cases excellent, ranging between 0.96 and 0.99 (p <  0.001). BPMSE-Sp had fewer floor and ceiling effects than the MMSE. The BPMSE-Sp is a valid tool for use in daily practice and research in the evaluation of cognitive function of patients with severe AD.

Though Arrow Says It’s Impossible, It Happens Everyday

OpenAIRE

Mohammad Gani

2004-01-01

Arrow’s Impossibility Theorem shows that transitive social preference is impossible. This note shows that in the general case of exchange, social preference need not be transitive. Indeed, it shows that social preference must be non-transitive to allow gainful exchange to maximize social welfare. Thus though Arrow says it is impossible, it actually happens everyday and everywhere.

Review the Physicists show EVERYTHING happens at the same time

DEFF Research Database (Denmark)

javadi, Hossein; Forouzbakhsh, Farshid

2016-01-01

Physicist Max Tegmark claims flow of time is illusion. EVERYTHING happens at the same time, Max Tegmark said. [1] To understand how this theory is consistent with the truth, it should be compared with physical previous theories and experiences. The theory is backed up Einstein’s theory...

Social Peer Interactions in Persons with Profound Intellectual and Multiple Disabilities: A Literature Review

Science.gov (United States)

Nijs, Sara; Maes, Bea

2014-01-01

Social interactions may positively influence developmental and quality of life outcomes. Research in persons with profound intellectual and multiple disabilities (PIMD) mostly investigated interactions with caregivers. This literature review focuses on peer interactions of persons with PIMD. A computerized literature search of three databases was…

"What happened to the research?"

DEFF Research Database (Denmark)

Bonde, Lars Ole

2007-01-01

From 1998 to 2005 twelve researchers graduated as PhDs from the International Music Therapy Research Training Program in Aalborg. They came from many different countries and clinical areas, and many types of research designs were represented. The researchers are all well-known within...... the international music therapy scene, but no overview has ever been made of how their research was disseminated or promoted in a wider national or international context. This paper addresses the following questions: “What happened to the research after the defence? How were the results of the research published...... and otherwise disseminated? What was the time frame and contexts of this dissemination process? What are the most important obstacles? Are we communicating in an appropriate way with professionals outside the music therapy community?” The paper is based on information provided by the researchers. Their results...

20 CFR 408.1226 - What happens if you are underpaid?

Science.gov (United States)

2010-04-01

... Section 408.1226 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition Payments § 408.1226 What happens if you are underpaid? If we determine that you are due an underpayment of State recognition payments, we will pay the...

'Doing theology as though nothing had happened' – reading Karl ...

African Journals Online (AJOL)

'Doing theology as though nothing had happened' – reading Karl Barth's confessional theology in Zimbabwe today? ... This article will attempt to argue that this theology can contribute to the Reformed theology in present day Zimbabwe. It will therefore attempt to introduce the confessional theology of Karl Barth to ...

Is more profound knowledge in the field of radiation nece--ssary for doctors

International Nuclear Information System (INIS)

Klener, V.

1981-01-01

Reasons are listed why doctors should have more profound knowledge in the field of radiation. Despite imperceptibility by human senses of ionizing radiation, the parameters characterizing irradiation can accurately be measured. The units of the said parameters are listed and characterized and the relationships are explained of the radiation dose and non-stochastic and stochastic radiation effects. (Ha)

HEART RATE AND PHYSICAL ACTIVITY PATTERNS IN PERSONS WITH PROFOUND INTELLECTUAL AND MULTIPLE DISABILITIES

NARCIS (Netherlands)

Waninge, Aly; van der Putten, Annette A. J.; Stewart, Roy E.; Steenbergen, Bert; van Wijck, Ruud; van der Schans, Cees P.

2013-01-01

Because physical fitness and health are related to physical activity, it is important to gain an insight into the physical activity levels of persons with profound intellectual and multiple disabilities (PIMD). The purpose of this study was to examine heart rate patterns to measure the activity

Driving to learn in a powered wheelchair: the process of learning joystick use in people with profound cognitive disabilities.

Science.gov (United States)

Nilsson, Lisbeth; Eklund, Mona; Nyberg, Per; Thulesius, Hans

2011-01-01

The Driving to Learn project explored ways to help people with profound cognitive disabilities practice operating a joystick-operated powered wheelchair. The project used a grounded theory approach with constant comparative analysis and was carried out over 12 yr. The participants were 45 children and adults with profound cognitive disabilities. Reference groups included 17 typically developing infants and 64 participants with lesser degrees of cognitive disability. The data sources included video recordings, field notes, open interviews, and a rich mixture of literature. The findings that emerged yielded strategies for facilitating achievements, an 8-phase learning process, an assessment tool, and a grounded theory of deplateauing explaining the properties necessary for participants to exceed expected limitations and plateaus. Eight participants with profound cognitive disabilities reached goal-directed driving or higher. Participants were empowered by attaining increased control over tool use, improving their autonomy and quality of life.

The effects of name and religious priming on ratings of a well-known political figure, President Barack Obama.

Science.gov (United States)

Williams, Gary A; Guichard, AnaMarie C; An, JungHa

2017-01-01

Priming with race-typed names and religious concepts have been shown to activate stereotypes and increase prejudice towards out-groups. We examined the effects of name and religious word priming on views of a specific and well-known person, President Barack Obama. We predicted that politically conservative participants primed with President Obama's middle name (Hussein) would rate him more negatively and be more likely to view him as a Muslim than those not shown his middle name. We also examined whether conservatives primed with concrete religious words would rate President Obama more negatively and be more likely to view him as Muslim than those primed with other word types. Furthermore, we predicted that those who mis-identify President Obama as Muslim would rate him more negatively than would those who view him as Christian. The results provided mixed support for these hypotheses. Conservatives primed with President Obama's middle name rated him significantly more negatively than did those in the control condition. This effect was not found for politically liberal or moderate participants. Name priming did not significantly affect views of President Obama's religious affiliation. Although not statistically significant, conservatives primed with abstract religious words tended to rate President Obama more negatively than did those primed with other word types. Religious word priming significantly influenced views of President Obama's religious affiliation; interestingly, participants primed with abstract religious words were more likely to think President Obama is Muslim than were those primed with religious agent or non-religious words. As predicted, participants who thought president Obama was Muslim rated him significantly more negatively than did those who thought he was Christian. Overall, our results provide some evidence that ethnic name and religious word priming can significantly influence opinions, even with a well-known and specific person.

2 CFR 180.360 - What happens if I fail to disclose information required under § 180.355?

Science.gov (United States)

2010-01-01

... Doing Business With Other Persons Disclosing Information-Lower Tier Participants § 180.360 What happens... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What happens if I fail to disclose information required under § 180.355? 180.360 Section 180.360 Grants and Agreements OFFICE OF MANAGEMENT AND...

Review the Physicists show EVERYTHING happens at the same time

OpenAIRE

javadi, Hossein; Forouzbakhsh, Farshid

2016-01-01

Physicist Max Tegmark claims flow of time is illusion. EVERYTHING happens at the same time, Max Tegmark said. [1] To understand how this theory is consistent with the truth, it should be compared with physical previous theories and experiences. The theory is backed up Einstein’s theory of relativity, Max Tegmark said. [1

Speech timing and working memory in profoundly deaf children after cochlear implantation

OpenAIRE

Burkholder, Rose A.; Pisoni, David B.

2003-01-01

Thirty-seven profoundly deaf children between 8- and 9-years-old with cochlear implants and a comparison group of normal-hearing children were studied to measure speaking rates, digit spans, and speech timing during digit span recall. The deaf children displayed longer sentence durations and pauses during recall and shorter digit spans compared to the normal-hearing children. Articulation rates, measured from sentence durations, were strongly correlated with immediate memory span in both norm...

20 CFR 408.1225 - What happens if you receive an overpayment?

Science.gov (United States)

2010-04-01

...? 408.1225 Section 408.1225 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition Payments § 408.1225 What happens... future Federally administered State recognition payments you are entitled to. Our rules and requirements...

7 CFR 15f.11 - Where must I file a hearing request and what happens to it?

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Where must I file a hearing request and what happens to it? 15f.11 Section 15f.11 Agriculture Office of the Secretary of Agriculture ADJUDICATIONS UNDER... must I file a hearing request and what happens to it? If you desire a hearing, you must file a request...

The Curriculum for Children with Severe and Profound Learning Difficulties at Stephen Hawking School

Science.gov (United States)

Rayner, Matthew

2011-01-01

The increasing number of children with profound and multiple learning difficulties means that many schools for children with severe learning difficulties are having to review the curriculum that they offer. In addition, these schools are continuing to question whether a subject-based approach, in line with the National Curriculum, is the most…

25 CFR 170.404 - What happens when a tribe uses its IRR Program construction funds for transportation planning?

Science.gov (United States)

2010-04-01

... of Indian Reservation Roads Program Facilities Transportation Planning § 170.404 What happens when a... 25 Indians 1 2010-04-01 2010-04-01 false What happens when a tribe uses its IRR Program construction funds for transportation planning? 170.404 Section 170.404 Indians BUREAU OF INDIAN AFFAIRS...

5 CFR 919.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What happens if I do business with an... Persons § 919.325 What happens if I do business with an excluded person in a covered transaction? If as a... PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) GOVERNMENTWIDE DEBARMENT AND...

What Happens at the House of Hope | NIH MedlinePlus the Magazine

Science.gov (United States)

... of Hope Follow us What Happens at the House of Hope? Discovery documentary showcases important research at ... at the Clinical Center also known as the “House of Hope.” Two of the patients have cancer ...

The Differential Effects of Attentional Focus in Children with Moderate and Profound Visual Impairments

Directory of Open Access Journals (Sweden)

Scott W. T. McNamara

2017-10-01

Full Text Available It has been consistently reported that an external focus of attention leads to better motor performance than an internal focus, but no research to date has explored this effect in a population with visual impairments (VI. External focus statements typically reference something in the environment (e.g., target that may be difficult to conceptualize for people with VI since they cannot generate a visual representation of the object of focus. Internal focus statements could be more closely identifiable with proprioception that is not impaired in this population. Recent studies have reported that sighted adults with temporarily obstructed vision are able to receive an external focus benefit when performing discrete tasks (i.e., golf putt and vertical jump, however, it is unclear if those with VI would experience the same benefit. The purpose of this investigation was to compare how an internal focus and external focus impact the balance of children with VI. Eighteen children with VI were grouped into a moderate (n = 11 and a profound VI group (n = 7. Participants completed a familiarization trial, an internal focus trial (i.e., focusing on feet and an external focus trial (i.e., focusing on markers in a counterbalanced order. The moderate VI group had a lower root mean square error while using an external focus (p = 0.04, while the profound VI group did not differ between conditions (p > 0.05. These results suggest that while performing a task reliant on sensory feedback, an external focus benefit may be dependent on the severity of VI. Further research is needed to examine whether external focus statements can be presented in a way that may be more intuitive to those with profound VI. These findings may help to influence how professionals in health-related fields (e.g., physical therapist and physical educators give instructions on motor performance to populations with VI.

Visual impairments in people with severe and profound multiple disabilities: An inventory of visual functioning

NARCIS (Netherlands)

van den Broek, E.G.C.; Janssen, C.G.C.; van Ramshorst, T.; Deen, L.

2006-01-01

Background: The prevalence of visual impairments in people with severe and profound multiple disabilities (SPMD) is the subject of considerable debate and is difficult to assess. Methods: In a typical Dutch care organization, all clients with SPMD (n = 76) participated in the study and specific

The pros and cons of inclusive education for children with Profound Intellectual and Multiple Disabilities

NARCIS (Netherlands)

Everaarts, Sanne; de Boer, Anke; van der Putten, Annette; Minnaert, Alexander

2016-01-01

Aim: Although children with disabilities have the right to be included into the school system, children with Profound Intellectual and Multiple Disabilities (PIMD) are often not included. The aim of this study is to gather knowledge about inclusive education for children with PIMD by identifying

Interaction between Persons with Profound Intellectual and Multiple Disabilities and Their Partners: A Literature Review

Science.gov (United States)

Hostyn, Ine; Maes, Bea

2009-01-01

Background: High quality interactions are of crucial importance for quality of life of persons with profound intellectual and multiple disabilities (PIMD). This literature review describes and synthesises studies addressing the interaction between persons with PIMD and their partners. Method: A computerised literature search using defined…

Specific needs of families of young adults with profound intellectual disability during and after transition to adulthood: What are we missing?

Science.gov (United States)

Gauthier-Boudreault, Camille; Gallagher, Frances; Couture, Mélanie

2017-07-01

At the age of 21, the trajectory of services offered to youth with profound intellectual disability (ID) change significantly since access to specialised services is more limited. Despite the desire of parents to avoid any impact on their child, several factors can influence the course of this transition. However, there is little research on facilitators and obstacles to the transition to adulthood, and impacts on people with a profound ID. It is therefore difficult to provide solutions that meet their specific needs. The study aimed to document the needs of parents and young adults with profound ID during and after the transition to adulthood by exploring their transitioning experience and factors that influenced it. Using a descriptive qualitative design, two individual semi-structured interviews were conducted with fourteen (14) parents of young adults aged between 18 and 26 with a profound ID. At this point, many material, informative, cognitive and emotional needs of young adults and their parents are not met. Obstacles, mainly organisational, persist and result in a particularly difficult transition to adulthood experience. By knowing the specific needs of these families, it is possible to develop and implement solutions tailored to their reality. WHAT THE PAPERS ADDS?: The transition to adulthood is a critical period for families with young adults with an intellectual disability (ID), a reality observed internationally. Current literature on all levels of ID suggests some barriers to transition that lead to negative impacts on both parents and young adults with ID. However, presently, very little research exists on the reality of families of young adults with profound ID and factors influencing transition to adult life. Most of studies target people with mild to moderate ID. Considering the significant disabilities of people with profound ID, it is possible to imagine that their experience of transition will be even more difficult and they will present

40 CFR 1042.320 - What happens if one of my production-line engines fails to meet emission standards?

Science.gov (United States)

2010-07-01

... an initial failed test if all of the following are true: (1) The catalyst was in a green condition... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What happens if one of my production... MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Testing Production-line Engines § 1042.320 What happens...

Undernutrition in children with profound intellectual and multiple disabilities (PIMD): its prevalence and influence on quality of life.

Science.gov (United States)

Holenweg-Gross, C; Newman, C J; Faouzi, M; Poirot-Hodgkinson, I; Bérard, C; Roulet-Perez, E

2014-07-01

To estimate the prevalence of undernutrition among children with profound intellectual and multiple disabilities (PIMD) and to explore its influence on quality of life. Seventy-two children with PIMD (47 male; 25 female; age range 2 to 15 years 4 months; mean age 8.6, SD 3.6) underwent an anthropometric assessment, including body weight, triceps skinfold thickness, segmental measures and recumbent length. Undernutrition was determined using tricipital skinfold percentile and z-scores of weight-for-height and height-for-age. The quality of life of each child was evaluated using the QUALIN questionnaire adapted for profoundly disabled children. Twenty-five children (34.7%) were undernourished and seven (9.7%) were obese. Among undernourished children only eight (32 %) were receiving food supplements and two (8%) had a gastrostomy, of which one was still on a refeeding programme. On multivariate analysis, undernutrition was one of the independent predictors of lower quality of life. Undernutrition remains a matter of concern in children with PIMD. There is a need to better train professionals in systematically assessing the nutritional status of profoundly disabled children in order to start nutritional management when necessary. © 2013 John Wiley & Sons Ltd.

The Role of Sound in Residential Facilities for People With Profound Intellectual and Multiple Disabilities

NARCIS (Netherlands)

van den Bosch, Kirsten A.; Andringa, Tjeerd C.; Baskent, Deniz; Vlaskamp, Carla

2016-01-01

Attention to the auditory environment of people with profound intellectual and multiple disabilities (PIMD) is limited, both in research and practice. As there is a dynamic interplay between the quality of the auditory environment and well-being, a study was undertaken to test the validity of the

Changing Homeland Security: The Issue-Attention Cycle

National Research Council Canada - National Science Library

Bellavita, Christopher

2005-01-01

.... But eventually -- as happened after the Madrid bombings in 2004 -- public vigilance will wane. This can be seen as an affirmation of the profound trust Americans place in their public safety professionals...

31 CFR 19.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false What happens if I do business with an excluded person in a covered transaction? 19.325 Section 19.325 Money and Finance: Treasury Office of the... Participants Regarding Transactions Doing Business with Other Persons § 19.325 What happens if I do business...

The Bhopal gas tragedy: could it have happened in a developed country?

Energy Technology Data Exchange (ETDEWEB)

Gupta, J.P. [Indian Inst. of Technology, Dept. of Chemical Engineering, Kanpur (India)

2002-01-01

The Bhopal gas tragedy occurred in December 1984 wherein approximately 41 tonnes of deadly MIC was released in the dead of night. It caused the death of over 3000 people and continued life-long misery for over 300,000 with certain genetic defects passed on to the next generation. It happened in a plant operated by a multinational, Union Carbide Corporation, in a developing country, India. The tragedy has changed the chemical process industry (CPI) forever. The results have been new legislation with better enforcement, enhancement in process safety, development of inherently safer plants, harsher court judgements, pro-active media and NGOs, rights-conscious public, and a CPI management willing to invest in safety related equipment and training. These have already resulted in savings of several hundred lives and over a billion dollars in accident damages [Kletz, T. (1998a). Process plants: a handbook of inherently safer designs. London: Taylor and Francis. Sutton, I. Chemical Engineering, 106(5), (1999). 114]. However, thousands did not have to die for the world to realise the disaster potential of CPI. The question that still remains is whether such an accident could have happened in a developed country. The answer is 'yes', as a number of major accidents in the developed countries since 1984, such as the Piper Alpha oil platform fire (1988, 167 killed), the Zeebrugge ferry disaster (1987, 167 killed), Phillips petroleum fire and explosion (1989,23 killed), the Challenger disaster (1986,7 killed), Esso Australia Longford explosion (1998, 2 killed) have demonstrated. One or more of the following are the primary reasons for such disasters: The indifferent attitude of the management towards safety, the lax enforcement of the existing regulations by the regulatory bodies as well as unusual delays in the judicial systems. Such conditions can happen regardless of the level of development in a country. Hence, the Bhopal gas tragedy could have happened in a

Demonstration of ipsilateral brain activation by noise in patients profoundly deaf with cochlear implant, or unilaterally deaf

International Nuclear Information System (INIS)

Herzog, H.; Wieler, H.; Morgenstern, C.; Lipman, J.; Langen, K.-J.; Schmid, A.; Rota, E.; Patton, D.; Feinendegen, L.F.

1986-01-01

Two groups of patients with hearing handicaps have been investigated with PET and F-18-2-FDG. Since these patients were unilaterally deaf or profoundly deaf with a cochlear implant installed, monaural stimulation was possible excluding any effects of bone conduction to the contralateral ear. White noise was used as acoustic stimulus in unilaterally deaf patients. The peripheral auditory nerve of cochlear implant patients was stimulated by electrical impulses which were encoded from music or a 4-tone mixture by an electronic speech processor. The non-music stimuli were chosen to avoid associative cortical reactions. In both groups response to the stimuli by increase of glucose consumption (LCMRglc) was found not only in the contralateral primary auditory cortex as expected from neuroanatomical knowledge, but also in the ipsilateral auditory cortex. Furthermore there was no correlation between the hemisphere showing increased LCMRglc and the side of stimulation or the type of stimulus. The similarity of results obtained in both groups by acoustical and electrical stimulation of the auditory nerve suggests that this kind of measurement might be a tool to predict or check the performance of a cochlear implant in a profoundly deaf patient. The finding of increased LCMRglc in the area of the normal auditory cortex in patients profoundly deaf since birth contradicts the hypothesis of degeneration of this cortical center in such patients. (Author)

International Stock Market Comovements: What Happened during the Financial Crisis?

Czech Academy of Sciences Publication Activity Database

Horváth, Roman; Poldauf, P.

2012-01-01

Roč. 12, č. 1 (2012), s. 1-21 ISSN 1524-5861 R&D Projects: GA ČR GA402/09/0965 Institutional research plan: CEZ:AV0Z10750506 Institutional support: RVO:67985556 Keywords : stock market comovements * financial crisis * GARCH Subject RIV: AH - Economics http://library.utia.cas.cz/separaty/2012/E/horvath-international stock market comovements what happened during the financial crisis .pdf

25 CFR 1000.227 - What happens if the Secretary denies the waiver request?

Science.gov (United States)

2010-04-01

... INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.227 What happens if the Secretary denies the waiver...

25 CFR 39.219 - What happens if a residential program does not maintain residency levels required by this subpart?

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What happens if a residential program does not maintain residency levels required by this subpart? 39.219 Section 39.219 Indians BUREAU OF INDIAN AFFAIRS..., Student Counts, and Verifications Residential Programs § 39.219 What happens if a residential program does...

Correlation between audiovestibular function tests and hearing outcomes in severe to profound sudden sensorineural hearing loss.

Science.gov (United States)

Wang, Chi-Te; Huang, Tsung-Wei; Kuo, Shih-Wei; Cheng, Po-Wen

2009-02-01

This study investigated whether audiovestibular function tests, namely auditory brain stem response (ABR) and vestibular-evoked myogenic potential (VEMP) tests were correlated to hearing outcomes after controlling the effects of other potential confounding factors in severe to profound sudden sensorineural hearing loss (SSHL). Eighty-eight patients with severe to profound SSHL were enrolled in this study. Pretreatment hearing levels, results of audiovestibular function tests, and final hearing outcomes were recorded from retrospective chart reviews. Other factors, including age, gender, delay of treatment, vertigo, diabetes mellitus, and hypertension, were collected as well. Comparative analysis between multiple variables and hearing outcomes was conducted using the cumulative logits model in overall subjects. Further, multivariate analysis of prognostic factors was conducted in the stratified groups of severe (70 dB HL 90 dB HL) SSHL. Multivariate analysis showed that pretreatment hearing levels, presence of vertigo, and results of ABR and VEMP testing were significant outcome predictors in the overall subjects. Stratification analysis demonstrated that both the presence of ABR and VEMP waveforms were significantly correlated with better hearing outcomes in the group of severe SSHL [ABR: adjusted odds ratio (aOR) = 14.7, 95% confidence interval (CI) = 1.78 to 122, p = 0.01; VEMP: aOR = 5.91, 95% CI = 1.18 to 29.5, p = 0.03], whereas the presence of vertigo was the only significant negative prognostic factor in the group of profound SSHL (aOR = 0.24, 95% CI = 0.06 to 0.95, p = 0.04). Other variables, including age, gender, diabetes mellitus, hypertension, and delay of treatment, were not significantly related to hearing outcomes in both groups (p > 0.05). A predictive hearing recovery table with the combined ABR and VEMP results was proposed for the group of severe SSHL. ABR and VEMP tests should be included in the battery of neurootological examinations in

Determining alertness in individuals with profound intellectual and multiple disabilities : the reliability of an observation list

NARCIS (Netherlands)

Munde, V.S.; Vlaskamp, C.; Ruijssenaars, A.J.J.M.; Nakken, H.

In the support of individuals with profound intellectual and multiple disabilities (PIMD), assessing the level of alertness is a recurring issue for parents and other direct support persons. Although observations show clear advantages above and beyond other assessment methods, there are problems

What Happened during the UN Decade of Education for Sustainable Development?

Science.gov (United States)

McKeown, Rosalyn

2015-01-01

The United Nations Decade of Education for Sustainable Development (DESD) drew to a close at the end of 2014. People ask: What happened? In broad brushstrokes, the author describes activities of the DESD in the formal and nonformal education sector of the education community. The author also identifies some enablers and barriers to advancing…

What will be Happen with New Mandala Transformation?

Directory of Open Access Journals (Sweden)

Sevenpri Candra

2011-05-01

Full Text Available Today’s business in airline is getting high. The competitive for pricing and services is getting tight. Each airlines battle to get profit growth. This problem is also feeling by Mandala Airlines. They conduct changing through inside and outside organization. They are reshaping the structure of their business to win the battle. Since mid of 2007, Mandala Airlines doing transformation. Under new management, there are full of confidence to changing. Changing their image into new modern airlines with international standard. What will be happen with New Mandala Transformation? Are they successfully doing transformation and can survive in this competition?

Normality and Impairment following Profound Early Institutional Deprivation: A Longitudinal follow-up into Early Adolescence

Science.gov (United States)

Kreppner, Jana M.; Rutter, Michael; Beckett, Celia; Castle, Jenny; Colvert, Emma; Groothues, Christine; Hawkins, Amanda; O'Connor, Thomas G.; Stevens, Suzanne; Sonuga-Barke, Edmund J. S.

2007-01-01

Longitudinal analyses on normal versus impaired functioning across 7 domains were conducted in children who had experienced profound institutional deprivation up to the age of 42 months and were adopted from Romania into U.K. families. Comparisons were made with noninstitutionalized children adopted from Romania and with nondeprived within-U.K.…

13 CFR 127.403 - What happens if SBA verifies the concern's eligibility?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if SBA verifies the concern's eligibility? 127.403 Section 127.403 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES Eligibility Examinations § 127...

Profound Endothelial Damage Predicts Impending Organ Failure and Death in Sepsis

DEFF Research Database (Denmark)

Johansen, Maria E; Johansson, Pär I.; Ostrowski, Sisse R

2015-01-01

levels at enrollment predicted risk of multiple organ failure during follow-up (HR [> 14 ng/mL vs. organ failure and death in septic......Endothelial damage contributes to organ failure and mortality in sepsis, but the extent of the contribution remains poorly quantified. Here, we examine the association between biomarkers of superficial and profound endothelial damage (syndecan-1 and soluble thrombomodulin [sTM], respectively......), organ failure, and death in sepsis. The data from a clinical trial, including critically ill patients predominantly suffering sepsis (Clinicaltrials.gov: NCT00271752) were studied. Syndecan-1 and sTM levels at the time of study enrollment were determined. The predictive ability of biomarker levels...

An atypical case of successful resuscitation of an accidental profound hypothermia patient, occurring in a temperate climate.

LENUS (Irish Health Repository)

Coleman, E

2010-03-01

Cases of accidental profound hypothermia occur most frequently in cold, northern climates. We describe an atypical case, occurring in a temperate climate, where a hypothermic cardiac-arrested patient was successfully resuscitated using extracorporeal circulation (ECC).

The study of 1H-MRS on monkey of resuscitation after cerebral selection ultra-profound hypothermic blood flow occlusion

International Nuclear Information System (INIS)

Pu Jun; Xu Wei; Fang Shaolong; Zhao Xinxiang; Feng Zhongtang; Jiang Jiyao

2005-01-01

Objective: To investigate the appearance and feature of 1 H/protion magnetic resonance spectroscopy ( 1 H-MRS) on resuscitation after cerebral selective ultra-profound hypothermic and blood flow occlusion. To study effects of cerebral biochemical metabolism after cerebral selective ultra-profound hypothermia and blood flow occlusion and to explore the validity and feasibility of it. Methods: Bilateral carotid arteries and jugular veins were clipped about 10 minutes before perfusion. Then selective cerebral circulation was established by perfusion of cooling lingers liquid through right internal carotid artery and flow out of left jugular vein with clip of other carotid arteries and jugular veins. Brain temperature reached (15.1 ± 0.9) degree C, while the body temperature maintained (32.50 ± 0.58) degree C. Cerebral blood recovered after 60 minutes of cerebral ischemia and monkey came back. The cerebral MAI and DWI as well as 1 H-MRS were examined 4, 24, 72 h, 21 days before and after cerebral selective ultro-profound hypothermia and blood flow occlusion. The peak of N-acetyl-aspartate (NAA), Choline (Cho), creatine and phosphocreatine (Cr, PCr) of VOL were compare with those of control group in different time. Results: MRI T 1 WI, MRI T 2 WI and DWI is normal in different time in different region; there was not a significant difference in the ratio of NAA/(Cr+PCr), Cho/(Cr+PCr) in ROI in different time in the different region in the light of statistical analysis (P>0.05). Conclusion: The light of cerebral biochemical metabolism, selective ultra-profound hypothermia is safety and may provide effective protective effects and safety during cerebral ischemia. (authors)

41 CFR 105-68.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What happens if I do business with an excluded person in a covered transaction? 105-68.325 Section 105-68.325 Public Contracts...-68.325 What happens if I do business with an excluded person in a covered transaction? If as a...

21 CFR 1.283 - What happens to food that is imported or offered for import without adequate prior notice?

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What happens to food that is imported or offered for import without adequate prior notice? 1.283 Section 1.283 Food and Drugs FOOD AND DRUG... Imported Food Consequences § 1.283 What happens to food that is imported or offered for import without...

41 CFR 102-75.930 - What happens if there is no objection by an appropriate committee or subcommittee of Congress...

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What happens if there is no objection by an appropriate committee or subcommittee of Congress concerning the proposed... happens if there is no objection by an appropriate committee or subcommittee of Congress concerning the...

Parental Adaptation to Out-of-Home Placement of a Child with Severe or Profound Developmental Disabilities

Science.gov (United States)

Jackson, Jeffrey B.; Roper, Susanne Olsen

2014-01-01

Utilizing grounded theory qualitative research methods, a model was developed for describing parental adaptation after voluntary placement of a child with severe or profound developmental disabilities in out-of-home care. Interviews of parents from 20 families were analyzed. Parents' cognitive appraisals of placement outcomes were classified…

Bereavement and Loss: Developing a Memory Box to Support a Young Woman with Profound Learning Disabilities

Science.gov (United States)

Young, Hannah; Garrard, Brenda

2016-01-01

Supporting bereaved people with profound learning disabilities still remains an under-researched area. Moreover, the barriers of communication and disenfranchised grief mean that they often do not receive the support they require, leading to emotional and behavioural difficulties. This article describes research using a case study design, which…

Attuning: A Communication Process between People with Severe and Profound Intellectual Disability and Their Interaction Partners

Science.gov (United States)

Griffiths, Colin; Smith, Martine

2016-01-01

Background: People with severe and profound intellectual disability typically demonstrate a limited ability to communicate effectively. Most of their communications are non-verbal, often idiosyncratic and ambiguous. This article aims to identify the process that regulates communications of this group of people with others and to describe the…

Reliability of assessing the sensory perception of children with profound intellectual and multiple disabilities : a case study

NARCIS (Netherlands)

Vlaskamp, C.; Cuppen-Fonteine, H.

Background This study describes preliminary stages of developing a checklist to enable practitioners to determine the behavioural responses of children with profound intellectual and multiple disabilities to sensory stimuli. Reliability of currently used checklists is low, with a focus on the

Profound vision loss impairs psychological well-being in young and middle-aged individuals

Directory of Open Access Journals (Sweden)

Garcia GA

2017-02-01

Full Text Available Giancarlo A Garcia,1,2 Matin Khoshnevis,1,3 Jesse Gale,1,4 Starleen E Frousiakis,1,5 Tiffany J Hwang,1,6 Lissa Poincenot,1 Rustum Karanjia,1,7–9 David Baron,6 Alfredo A Sadun1,7 1Doheny Eye Institute, Los Angeles, CA, USA; 2University of California, Irvine School of Medicine, Irvine, CA, USA; 3Department of Ophthalmology, Temple University, Philadelphia, PA, USA; 4Wellington School of Medicine and Health Sciences, University of Otago, Wellington, NZ; 5Department of Ophthalmology, New York Medical College, Valhalla, NY, USA; 6Department of Psychiatry & The Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 7Doheny Eye Centers, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles California, CA, USA; 8Department of Ophthalmology, University of Ottawa, Ottawa, ON, Canada; 9Ottawa Hospital Health Research Institute, Ottawa, ON, Canada Purpose: The aim of this study was to evaluate the effects of profound vision loss on psychological well-being in adolescents, young adults, and middle-aged adults with regard to mood, interpersonal interactions, and career-related goals. In addition, we assessed the significance of the resources that may be used to enhance psychological well-being in cases of profound vision loss, and in particular, examined the utility of low vision aids and the role of the ophthalmologist as a provider of emotional support.Methods: A questionnaire was issued to individuals aged 13–65 years with profound vision loss resulting from Leber’s hereditary optic neuropathy (LHON. Depression prevalence was evaluated with questions regarding major depressive disorder symptomatology. Participants appraised the effects of vision loss on their interpersonal interactions and career goals by providing an impact rating (IR on a 21-point psychometric scale from −10 to +10. Social well-being index was defined as the average of interpersonal IR and career IR

Histones induce rapid and profound thrombocytopenia in mice

Science.gov (United States)

Bhandari, Ashish A.

2011-01-01

Histones are released from dying cells and contribute to antimicrobial defense during infection. However, extracellular histones are a double-edged sword because they also damage host tissue and may cause death. We studied the interactions of histones with platelets. Histones bound to platelets, induced calcium influx, and recruited plasma adhesion proteins such as fibrinogen to induce platelet aggregation. Hereby fibrinogen cross-linked histone-bearing platelets and triggered microaggregation. Fibrinogen interactions with αIIbβ3 integrins were not required for this process but were necessary for the formation of large platelet aggregates. Infused histones associated with platelets in vivo and caused a profound thrombocytopenia within minutes after administration. Mice lacking platelets or αIIbβ3 integrins were protected from histone-induced death but not from histone-induced tissue damage. Heparin, at high concentrations, prevented histone interactions with platelets and protected mice from histone-induced thrombocytopenia, tissue damage, and death. Heparin and histones are evolutionary maintained. Histones may combine microbicidal with prothrombotic properties to fight invading microbes and maintain hemostasis after injury. Heparin may provide an innate counter mechanism to neutralize histones and diminish collateral tissue damage. PMID:21700775

Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients.

Science.gov (United States)

Riahi, Zied; Bonnet, Crystel; Zainine, Rim; Lahbib, Saida; Bouyacoub, Yosra; Bechraoui, Rym; Marrakchi, Jihène; Hardelin, Jean-Pierre; Louha, Malek; Largueche, Leila; Ben Yahia, Salim; Kheirallah, Moncef; Elmatri, Leila; Besbes, Ghazi; Abdelhak, Sonia; Petit, Christine

2015-01-01

Usher syndrome (USH) is an autosomal recessive disorder characterized by combined deafness-blindness. It accounts for about 50% of all hereditary deafness blindness cases. Three clinical subtypes (USH1, USH2, and USH3) are described, of which USH1 is the most severe form, characterized by congenital profound deafness, constant vestibular dysfunction, and a prepubertal onset of retinitis pigmentosa. We performed whole exome sequencing in four unrelated Tunisian patients affected by apparently isolated, congenital profound deafness, with reportedly normal ocular fundus examination. Four biallelic mutations were identified in two USH1 genes: a splice acceptor site mutation, c.2283-1G>T, and a novel missense mutation, c.5434G>A (p.Glu1812Lys), in MYO7A, and two previously unreported mutations in USH1G, i.e. a frameshift mutation, c.1195_1196delAG (p.Leu399Alafs*24), and a nonsense mutation, c.52A>T (p.Lys18*). Another ophthalmological examination including optical coherence tomography actually showed the presence of retinitis pigmentosa in all the patients. Our findings provide evidence that USH is under-diagnosed in Tunisian deaf patients. Yet, early diagnosis of USH is of utmost importance because these patients should undergo cochlear implant surgery in early childhood, in anticipation of the visual loss.

Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice

Directory of Open Access Journals (Sweden)

Yanfei Wang

2017-12-01

Full Text Available Calcium and integrin-binding protein 2 (CIB2 belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Among the family members, the Cib1 and Cib2 genes are expressed in mouse cochlear hair cells, and mutations in the human CIB2 gene have been associated with nonsyndromic deafness DFNB48 and syndromic deafness USH1J. To further explore the function of CIB1 and CIB2 in hearing, we established Cib1 and Cib2 knockout mice using the clustered regularly interspaced short palindromic repeat (CRISPR-associated Cas9 nuclease (CRISPR/Cas9 genome editing technique. We found that loss of CIB1 protein does not affect auditory function, whereas loss of CIB2 protein causes profound hearing loss in mice. Further investigation revealed that hair cell stereocilia development is affected in Cib2 knockout mice. Noticeably, loss of CIB2 abolishes mechanoelectrical transduction (MET currents in auditory hair cells. In conclusion, we show here that although both CIB1 and CIB2 are readily detected in the cochlea, only loss of CIB2 results in profound hearing loss, and that CIB2 is essential for auditory hair cell MET.

Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients.

Directory of Open Access Journals (Sweden)

Zied Riahi

Full Text Available Usher syndrome (USH is an autosomal recessive disorder characterized by combined deafness-blindness. It accounts for about 50% of all hereditary deafness blindness cases. Three clinical subtypes (USH1, USH2, and USH3 are described, of which USH1 is the most severe form, characterized by congenital profound deafness, constant vestibular dysfunction, and a prepubertal onset of retinitis pigmentosa. We performed whole exome sequencing in four unrelated Tunisian patients affected by apparently isolated, congenital profound deafness, with reportedly normal ocular fundus examination. Four biallelic mutations were identified in two USH1 genes: a splice acceptor site mutation, c.2283-1G>T, and a novel missense mutation, c.5434G>A (p.Glu1812Lys, in MYO7A, and two previously unreported mutations in USH1G, i.e. a frameshift mutation, c.1195_1196delAG (p.Leu399Alafs*24, and a nonsense mutation, c.52A>T (p.Lys18*. Another ophthalmological examination including optical coherence tomography actually showed the presence of retinitis pigmentosa in all the patients. Our findings provide evidence that USH is under-diagnosed in Tunisian deaf patients. Yet, early diagnosis of USH is of utmost importance because these patients should undergo cochlear implant surgery in early childhood, in anticipation of the visual loss.

A Preliminary Investigation of the Suitability of Aquatics for People with Severe and Profound Intellectual Disabilities

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Aherne, Cian; Coughlan, Barry

2017-01-01

Background: Aquatics is an under-researched but possibly appropriate form of activity for people with severe to profound intellectual disabilities (SPIDs). Aim: The current pilot study investigates the suitability of an aquatics programme for service users with SPIDs. Method: Four service users with SPID completed an 8-12-session aquatics…

Attentional Processes in Interactions between People with Profound Intellectual and Multiple Disabilities and Direct Support Staff

Science.gov (United States)

Ine, Hostyn; Heleen, Neerinckx; Bea, Maes

2011-01-01

Few studies have examined joint attention in interactions with persons with profound intellectual and multiple disabilities (PIMD), despite its important role in high-quality interaction. The purpose of this study is to describe the attention-directing behaviours of persons with PIMD and their direct support staff and the attention episodes…

43 CFR 30.127 - What happens if property was improperly included in the inventory?

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2010-10-01

... Interior INDIAN PROBATE HEARINGS PROCEDURES Judicial Authority and Duties § 30.127 What happens if property... proceeding, it is found that property has been improperly included in the inventory of an estate, the...

40 CFR 60.2918 - What happens during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... of startup, shutdown, and malfunction? The emission limitations and operating limits apply at all times except during OSWI unit startups, shutdowns, or malfunctions. Performance Testing ...

Therapeutic interventions in the Netherlands and Belgium in support of people with profound intellectual and multiple disabilities

NARCIS (Netherlands)

Vlaskamp, Carla; Nakken, Han

For several reasons, people with profound and multiple disabilities may be offered a variety of therapeutic interventions. Thus far, researchers have shown a limited interest in providing an empirical base for these interventions. Research is needed on the theoretical rationale (if any), the

21 CFR 1.285 - What happens to food that is imported or offered for import from unregistered facilities that are...

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false What happens to food that is imported or offered....285 Section 1.285 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Prior Notice of Imported Food Consequences § 1.285 What happens to...

Camera-based microswitch technology to monitor mouth, eyebrow, and eyelid responses of children with profound multiple disabilities

NARCIS (Netherlands)

Lancioni, G.E.; Bellini, D.; Oliva, D.; Singh, N.N.; O'Reilly, M.F.; Sigafoos, J.; Lang, R.B.; Didden, H.C.M.

2011-01-01

A camera-based microswitch technology was recently used to successfully monitor small eyelid and mouth responses of two adults with profound multiple disabilities (Lancioni et al., Res Dev Disab 31:1509-1514, 2010a). This technology, in contrast with the traditional optic microswitches used for

Experience with cochlear implants in Greenlanders with profound hearing loss living in Greenland

DEFF Research Database (Denmark)

Homøe, Preben; Andersen, Ture; Grøntved, Aksel

2013-01-01

OBJECTIVE: Cochlear implant (CI) treatment was introduced to the world in the 1980s and has become a routine treatment for congenital or acquired severe-to-profound hearing loss. CI treatment requires access to a highly skilled team of ear, nose and throat specialists, audiologists and speech...... years are in need of a CI every second year in Greenland often due to sequelae from meningitis, which may cause postinfectious deafness. Screening of new-borns for hearing has been started in Greenland establishing the basis for early diagnosis of congenital hearing impairment and subsequent...

40 CFR 310.24 - What happens if I provide incorrect or false information?

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2010-07-01

... false information? 310.24 Section 310.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 310.24 What happens if I provide incorrect or false information? (a) You must not knowingly or recklessly make any statement or provide any information in your reimbursement application that is false...

40 CFR 60.3025 - What happens during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... during periods of startup, shutdown, and malfunction? The emission limitations and operating limits apply at all times except during OSWI unit startups, shutdowns, or malfunctions. Model Rule—Performance...

Motor activation in people with profound intellectual and multiple disabilities: research in daily practice in residential facilities

NARCIS (Netherlands)

Bossink, Leontien; van der Putten, Annette; Vlaskamp, Carla

2014-01-01

Aim: The total study aims at generating knowledge about the best way to motor activate persons with profound intellectual and multiple disabilities (PIMD) in residential facilities. The purpose of the current poster presentation is to present the results of the first step executed in this project

How Do We Make Inclusive Education Happen When Exclusion Is a Political Predisposition?

Science.gov (United States)

Slee, Roger

2013-01-01

Convening a conference under the banner: Making Inclusion Happen, reminds us that the struggle for disabled people's rights to the minimum expectations of citizenship; access to education, work, housing, health care, civic connection remains urgent. Notwithstanding the hard fought for United Nations, human rights charters and national…

Outcomes of laryngohyoid suspension techniques in an ovine model of profound oropharyngeal dysphagia.

Science.gov (United States)

Johnson, Christopher M; Venkatesan, Naren N; Siddiqui, M Tausif; Cates, Daniel J; Kuhn, Maggie A; Postma, Gregory M; Belafsky, Peter C

2017-12-01

To evaluate the efficacy of various techniques of laryngohyoid suspension in the elimination of aspiration utilizing a cadaveric ovine model of profound oropharyngeal dysphagia. Animal study. The head and neck of a Dorper cross ewe was placed in the lateral fluoroscopic view. Five conditions were tested: baseline, thyroid cartilage to hyoid approximation (THA), thyroid cartilage to hyoid to mandible (laryngohyoid) suspension (LHS), LHS with cricopharyngeus muscle myotomy (LHS-CPM), and cricopharyngeus muscle myotomy (CPM) alone. Five 20-mL trials of barium sulfate were delivered into the oropharynx under fluoroscopy for each condition. Outcome measures included the penetration aspiration scale (PAS) and the National Institutes of Health (NIH) Swallow Safety Scale (NIH-SSS). Median baseline PAS and NIH-SSS scores were 8 and 6, respectively, indicating severe impairment. THA scores were not improved from baseline. LHS alone reduced the PAS to 1 (P = .025) and NIH-SSS to 2 (P = .025) from baseline. LHS-CPM reduced the PAS to 1 (P = .025) and NIH-SSS to 0 (P = .025) from baseline. CPM alone did not improve scores. LHS-CPM displayed improved NIH-SSS over LHS alone (P = .003). This cadaveric model represents end-stage profound oropharyngeal dysphagia such as what could result from severe neurological insult. CPM alone failed to improve fluoroscopic outcomes in this model. Thyrohyoid approximation also failed to improve outcomes. LHS significantly improved both PAS and NIH-SSS. The addition of CPM to LHS resulted in improvement over suspension alone. NA. Laryngoscope, 127:E422-E427, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

The Effect of Frequency Transposition on Speech Perception in Adolescents and Young Adults with Profound Hearing Loss

Science.gov (United States)

Gou, J.; Smith, J.; Valero, J.; Rubio, I.

2011-01-01

This paper reports on a clinical trial evaluating outcomes of a frequency-lowering technique for adolescents and young adults with severe to profound hearing impairment. Outcomes were defined by changes in aided thresholds, speech perception, and acceptance. The participants comprised seven young people aged between 13 and 25 years. They were…

How to Facilitate Transition to Adulthood? Innovative Solutions from Parents of Young Adults with Profound Intellectual Disability

Science.gov (United States)

Gauthier-Boudreault, Camille; Couture, Mélanie; Gallagher, Frances

2018-01-01

Background: At age 21, access to specialised services for youth with profound intellectual disability is reduced. Few studies have focused on parents' views concerning potential solutions to ease the transition to adulthood, and most existing solutions target young adults with less severe intellectual disability. The aim of this study is to…

Family matters : The experiences and opinions of family members of persons with (severe) or profound intellectual disabilities

NARCIS (Netherlands)

Luijkx, Jorien

2016-01-01

“I love my sister, but sometimes I don’t”. This is one of the statements made in the study focused on the experiences of family members of people with (profound) intellectual (and multiple) disabilities (both of individuals living in a residential facility as persons living at home). In recent

Transitioning hearing aid users with severe and profound loss to a new gain/frequency response: benefit, perception, and acceptance.

Science.gov (United States)

Convery, Elizabeth; Keidser, Gitte

2011-03-01

Adults with severe and profound hearing loss tend to be long-term, full-time users of amplification who are highly reliant on their hearing aids. As a result of these characteristics, they are often reluctant to update their hearing aids when new features or signal-processing algorithms become available. Due to the electroacoustic constraints of older devices, many severely and profoundly hearing-impaired adults continue to wear hearing aids that provide more low- and mid-frequency gain and less high-frequency gain than would be prescribed by the National Acoustic Laboratories' revised formula with profound correction factor (NAL-RP). To investigate the effect of a gradual change in gain/frequency response on experienced hearing-aid wearers with moderately severe to profound hearing loss. Double-blind, randomized controlled trial. Twenty-three experienced adult hearing-aid users with severe and profound hearing loss participated in the study. Participants were selected for inclusion in the study if the gain/frequency response of their own hearing aids differed significantly from their NAL-RP prescription. Participants were assigned either to a control or to an experimental group balanced for aided ear three-frequency pure-tone average (PTA) and age. Participants were fitted with Siemens Artis 2 SP behind-the-ear (BTE) hearing aids that were matched to the gain/frequency response of their own hearing aids for a 65 dB SPL input level. The experimental group progressed incrementally to their NAL-RP targets over the course of 15 wk, while the control group maintained their initial settings throughout the study. Aided speech discrimination testing, loudness scaling, and structured questionnaires were completed at 3, 6, 9, 12, and 15 wk postfitting. A paired comparison between the old and new gain/frequency responses was completed at 1 and 15 wk postfitting. Statistical analysis was conducted to examine differences between the experimental and control groups and changes

Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study - Efficacy, safety, and pharmacokinetics

NARCIS (Netherlands)

Sparr, Harald J.; Vermeyen, Karel M.; Beaufort, Anton M.; Rietbergen, Henk; Proost, Johannes H.; Saldien, Vera; Velik-Salchner, Corinna; Wierda, J. Mark K. H.

Background: Sugammadex reverses the neuromuscular blocking effects of rocuronium by chemical encapsulation. The efficacy, safety, and pharmacokinetics of sugammadex for reversal of profound rocuronium-induced neuromuscular blockade were evaluated. Methods: Ninety-eight male adult patients were

You Should be Dancin:! The Role of Performing Arts in the Lives of the Severely and Profoundly Handicapped.

Science.gov (United States)

Barringer, Mary Dean

The manual presents a program planning framework and teaching units for teaching dance and movement to severely and profoundly handicapped individuals. The planning framework contains four components: (1) aesthetic perception/multisensory integration; (2) creative expression; (3) dance heritage/historical and cultural; and (4) aesthetic…

Catch the wave! Time-window sequential analysis of alertness stimulation in individuals with profound intellectual and multiple disabilities

NARCIS (Netherlands)

Munde, V. S.; Vlaskamp, C.; Maes, B.; Ruijssenaars, A. J. J. M.

BackgroundWhile optimally activities are provided at those moments when the individual with profound intellectual and multiple disabilities (PIMD) is focused on the environment' or alert', detailed information about the impact that the design and timing of the activity has on alertness is lacking.

The documentation of health problems in relation to prescribed medication in people with profound intellectual and multiple disabilities

NARCIS (Netherlands)

van der Heide, D. C.; van der Putten, A. A. J.; van den Berg, P. B.; Taxis, K.; Vlaskamp, C.

Persons with profound intellectual and multiple disabilities (PIMD) suffer from a wide range of health problems and use a wide range of different drugs. This study investigated for frequently used medication whether there was a health problem documented in the medical notes for the drug prescribed.

Staff attributions of the causes of challenging behaviour in children and adults with profound intellectual and multiple disabilities

NARCIS (Netherlands)

Poppes, P.; van der Putten, A.A.J.; ten Brug, A.; Vlaskamp, C.

A study has shown that staff do not generally perceive challenging behaviour in people with profound intellectual and multiple disabilities (PIMD) as being of serious consequence. In this study we aimed to gain a better understanding of the causal explanations that direct care and support staff give

The causal effect of profound organizational change when job insecurity is low – a quasi-experiment analysing municipal mergers

DEFF Research Database (Denmark)

Bhatti, Yosef; Gørtz, Mette; Pedersen, Lene Holm

2015-01-01

The present article finds that the causal effect of profound organizational change on employee health can be very low, if job insecurity is mitigated. We demonstrate this by investigating a rare case of a large-scale radical public sector reform with low job insecurity, in which a large number...... and job insecurity may explain the divergence from previous results. An important strength of our study is that the reform investigated can be considered a quasi-experiment, as it was exogenous and implemented simultaneously by the affected local governments. We also have access to an objective measure...... of robustness tests are performed, including propensity score matching and in-depth analysis of particular sub-groups of public sector employees. The results indicate that profound organizational change per se does not necessarily lead to decreased health, if job insecurity is low. However, a very modest effect...

Weltanschauung und Politik in den heutigen USA. Barack Obama und der „neue Kulturkampf“ um die Führung der anglo-amerikanischen Weltmacht

Directory of Open Access Journals (Sweden)

Roland Benedikter

2010-06-01

Full Text Available This article provides an analysis of the current relationship between Politics, Culture and Worldviews in the USA under Barack Obama. The present "great Obama divide" of US domestic politics consists in the division between institutional and contextual (cultural and worldview politics. Obama has induced their current opposition when he ran for the US Presidency by profiling himself as a "cultural" candidate "against the system". One result is that by becoming part of the system after being elected, Obama has lost some of his initial "revolutionary" appeal; a second effect is that the opposition is now trying to turn the tables by mobilizing the contextual political sphere against Obama’s control of the institutional power. In fact, the Republicans, rather than concentrating on traditional ways of regaining power focus on launching a new "worldview" battle against Obama in the hope to use the pre-political sphere to eventually regain the institutional political majority. The overall result is a general climate of "worldview mobilization" in the USA, and an increased influence of cultural and worldview philosophies onto the institutionalized mechanisms of politics. Pre-political movements like the conservative "inverting the myth - inverting the paradigm" movement or the "tea party" movement are the expression of attempts towards a new "cultural battle" for "the soul of the USA," which has to be understood in its basic mechanisms, if the "Obama constellation" shall be understood. This article sketches some core elements of Obama’s worldview that are in play in this game, and it argues that many actions of Obama on the field of foreign politics are (and will be to a noticeable extent co-oriented toward influencing the domestic "worldview battle."

Developmental dysgraphia with profound hearing impairment: intervention by auditory methods enabled by cochlear implant.

Science.gov (United States)

Fukushima, Kunihiro; Kawasaki, Akihiro; Nagayasu, Rie; Kunisue, Kazuya; Maeda, Yukihide; Kariya, Shin; Kataoka, Yuko; Nishizaki, Kazunori

2008-06-01

Learning disability combined with hearing impairment (LDHI) is a poor prognostic factor for the language development of hearing impaired children after educational intervention. A typical example of a child with LDHI and effective interventions provided by cochlear implants are presented in this report. A case of congenital cytomegaloviral infection that showed dysgraphia as well as profound deafness was reported and an underlying visual processing problem diagnosed in the present case caused the patient's dysgraphia. The dysgraphia could be circumvented by the use of auditory memory fairly established by a cochlear implant.

An Evaluation of Social and Adaptive Skills in Adults with Bipolar Disorder and Severe/Profound Intellectual Disability

Science.gov (United States)

Matson, Johnny L.; Terlonge, Cindy; Gonzalez, Melissa L.; Rivet, Tessa

2006-01-01

The purpose of this study was to explore the interrelationship of social and adaptive skills in adults with bipolar disorder and severe or profound intellectual disability. A bipolar group (N=14), a severe psychopathology group without bipolar disorder (N=14), and a control group with no DSM-IV Axis I diagnosis (N=14) were compared on the…

"Do You Teach Them Anything?" What Really Happens in a Montessori Toddler Class

Science.gov (United States)

Dore, Heather S.

2014-01-01

The greatest sign of success for a teacher is to be able to say, "The children are now working as if I did not exist" (Montessori, 1967, p. 283). Montessori Toddler teachers spend a great amount of time preparing and perfecting their environments to allow and to encourage learning to happen. The teachers are constantly adjusting and…

Developing a questionnaire on physical activity support of people with (profound) intellectual (and multiple) disabilities : Experiences from the Netherlands

NARCIS (Netherlands)

Bossink, Leontien; van der Putten, Annette; Vlaskamp, Carla

2017-01-01

Introduction: People with intellectual disabilities (ID) undertake extremely low levels of physical activity, which is even more true in people with profound intellectual and multiple disabilities (PIMD). Physical activity approaches, particularly for people with PIMD, are more likely to be

41 CFR 102-75.420 - What happens if the FAA informs the disposal agency that it does not recommend disposal of the...

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What happens if the FAA... Real Property Disposal Property for Public Airports § 102-75.420 What happens if the FAA informs the... property that the FAA does not recommend for disposal as a public airport must be disposed of in accordance...

Quality-Enhancing Interventions for People with Profound Intellectual and Multiple Disabilities: A Review of the Empirical Research Literature

Science.gov (United States)

Maes, Bea; Lambrechts, Greet; Hostyn, Ine; Petry, Katja

2007-01-01

Background: This study provides an overview of empirical research on the effectiveness of quality-enhancing interventions for people with profound intellectual and multiple disabilities (PIMD). Method: Through computerised searches of the PsycINFO and ERIC databases, and using several search criteria specifically relating to the target group and…

Speech perception, production and intelligibility in French-speaking children with profound hearing loss and early cochlear implantation after congenital cytomegalovirus infection.

Science.gov (United States)

Laccourreye, L; Ettienne, V; Prang, I; Couloigner, V; Garabedian, E-N; Loundon, N

2015-12-01

To analyze speech in children with profound hearing loss following congenital cytomegalovirus (cCMV) infection with cochlear implantation (CI) before the age of 3 years. In a cohort of 15 children with profound hearing loss, speech perception, production and intelligibility were assessed before and 3 years after CI; variables impacting results were explored. Post-CI, median word recognition was 74% on closed-list and 48% on open-list testing; 80% of children acquired speech production; and 60% were intelligible for all listeners or listeners attentive to lip-reading and/or aware of the child's hearing loss. Univariate analysis identified 3 variables (mean post-CI hearing threshold, bilateral vestibular areflexia, and brain abnormality on MRI) with significant negative impact on the development of speech perception, production and intelligibility. CI showed positive impact on hearing and speech in children with post-cCMV profound hearing loss. Our study demonstrated the key role of maximizing post-CI hearing gain. A few children had insufficient progress, especially in case of bilateral vestibular areflexia and/or brain abnormality on MRI. This led us to suggest that balance rehabilitation and speech therapy should be intensified in such cases. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

25 CFR 170.811 - What happens if lack of funds results in inadequate maintenance?

Science.gov (United States)

2010-04-01

... maintenance? 170.811 Section 170.811 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM BIA Road Maintenance § 170.811 What happens if lack of funds results in inadequate maintenance? If BIA determines that an IRR transportation facility is not being...

Quantification of structural changes in the corpus callosumin children with profound hypoxic-ischaemic brain injury

Energy Technology Data Exchange (ETDEWEB)

Stivaros, Stavros M. [Manchester Academic Health Science Centre, Academic Unit of Paediatric Radiology, Royal Manchester Children' s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester (United Kingdom); University of Manchester, Centre for Imaging Sciences, Institute of Population Health, Manchester (United Kingdom); Radon, Mark R. [The Walton Centre NHS Foundation Trust, Department of Neuroradiology, Liverpool (United Kingdom); Mileva, Reneta; Gledson, Ann; Keane, John A. [University of Manchester, School of Computer Science, Manchester (United Kingdom); Connolly, Daniel J.A.; Batty, Ruth [Sheffield Children' s Hospital NHS Foundation Trust, Department of Neuroradiology, Sheffield (United Kingdom); Cowell, Patricia E. [University of Sheffield, Department of Human Communication Sciences, Sheffield (United Kingdom); Hoggard, Nigel; Griffiths, Paul D. [University of Sheffield, Academic Unit of Radiology, Sheffield (United Kingdom); Wright, Neville B.; Tang, Vivian [Manchester Academic Health Science Centre, Academic Unit of Paediatric Radiology, Royal Manchester Children' s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester (United Kingdom)

2016-01-15

Birth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules. To test the hypothesis that there is anatomically coherent regional volume loss of the corpus callosum as a result of this hemispheric abnormality. Study subjects included 13 children with proven acute profound hypoxic-ischaemic brain injury and 13 children with developmental delay but no brain abnormalities. A computerised system divided the corpus callosum into 100 segments, measuring each width. Principal component analysis grouped the widths into contiguous anatomical regions. We conducted analysis of variance of corpus callosum widths as well as support vector machine stratification into patient groups. There was statistically significant narrowing of the mid-posterior body and genu of the corpus callosum in children with hypoxic-ischaemic brain injury. Support vector machine analysis yielded over 95% accuracy in patient group stratification using the corpus callosum centile widths. Focal volume loss is seen in the corpus callosum of children with hypoxic-ischaemic brain injury secondary to loss of commissural fibres arising in the paracentral lobules. Support vector machine stratification into the hypoxic-ischaemic brain injury group or the control group on the basis of corpus callosum width is highly accurate and points towards rapid clinical translation of this technique as a potential biomarker of hypoxic-ischaemic brain injury. (orig.)

Quantification of structural changes in the corpus callosumin children with profound hypoxic-ischaemic brain injury

International Nuclear Information System (INIS)

Stivaros, Stavros M.; Radon, Mark R.; Mileva, Reneta; Gledson, Ann; Keane, John A.; Connolly, Daniel J.A.; Batty, Ruth; Cowell, Patricia E.; Hoggard, Nigel; Griffiths, Paul D.; Wright, Neville B.; Tang, Vivian

2016-01-01

Birth-related acute profound hypoxic-ischaemic brain injury has specific patterns of damage including the paracentral lobules. To test the hypothesis that there is anatomically coherent regional volume loss of the corpus callosum as a result of this hemispheric abnormality. Study subjects included 13 children with proven acute profound hypoxic-ischaemic brain injury and 13 children with developmental delay but no brain abnormalities. A computerised system divided the corpus callosum into 100 segments, measuring each width. Principal component analysis grouped the widths into contiguous anatomical regions. We conducted analysis of variance of corpus callosum widths as well as support vector machine stratification into patient groups. There was statistically significant narrowing of the mid-posterior body and genu of the corpus callosum in children with hypoxic-ischaemic brain injury. Support vector machine analysis yielded over 95% accuracy in patient group stratification using the corpus callosum centile widths. Focal volume loss is seen in the corpus callosum of children with hypoxic-ischaemic brain injury secondary to loss of commissural fibres arising in the paracentral lobules. Support vector machine stratification into the hypoxic-ischaemic brain injury group or the control group on the basis of corpus callosum width is highly accurate and points towards rapid clinical translation of this technique as a potential biomarker of hypoxic-ischaemic brain injury. (orig.)

25 CFR 170.501 - What happens when the review process identifies areas for improvement?

Science.gov (United States)

2010-04-01

... identifies areas for improvement? When the review process identifies areas for improvement: (a) The regional... 25 Indians 1 2010-04-01 2010-04-01 false What happens when the review process identifies areas for improvement? 170.501 Section 170.501 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND...

Profound hypoglycemia-ınduced by vaccinium corymbosum juice and laurocerasus fruit.

Science.gov (United States)

Aktan, Ahmet Hamdi; Ozcelik, Abdullah; Cure, Erkan; Cure, Medine Cumhur; Yuce, Suleyman

2014-01-01

An emergency intervention was performed in a 75-year-old male patient with hypoglycemic attack and blackout. Although he was diagnosed with prediabetes before 2 years, he did not take any anti-diabetic drug or follow dietary advice. He drank Vaccinium corymbosum L (VC) juice daily with a belief that it increases sexual potency. Before the development of hypoglycemia, the patient had consumed about 500 ml VC juice in addition to eating 200-300 gram of Laurocerasus officinalis (LO) fruit. The measured plasma glucose (PG) level during loss of consciousness was 30 mg/dl. The profound hypoglycemia may be an unexpected side effect of an interaction between the chemical compositions of the two plants, occurred as a result of LO fruit intake that may have a strong PG-lowering effect or related to excessive intake of VC juice. Both plants may be considered in the alternative treatment of diabetes.

Basic life support and children with profound and multiple learning disabilities.

Science.gov (United States)

Cash, Stefan; Shinnick-Page, Andrea

2008-10-01

Nurses and other carers of people with learning disabilities must be able to manage choking events and perform basic life support effectively. UK guidelines for assessment of airway obstruction and for resuscitation do not take account of the specific needs of people with profound multiple learning disability. For example, they fail to account for inhibited gag and coughing reflexes, limited body movements or chest deformity. There are no national guidelines to assist in clinical decisions and training for nurses and carers. Basic life support training for students of learning disability nursing at Birmingham City University is supplemented to address these issues. The authors ask whether such training should be provided for all nurses including those caring for children and young people. They also invite comment and discussion on questions related to chest compression and training in basic life support for a person in a seated position.

Happening'id ja disain - visioon kunsti ja elu terviklikkusest / Mari Laanemets

Index Scriptorium Estoniae

Laanemets, Mari, 1975-

2010-01-01

Analüüsitakse kunsti ja disaini vahelist suhet 1970. aastatel esile kerkinud uue kunstikäsitluse ja kunstilise tegevuse ümbermõtestamise kontekstis. Mõlemad pidid lepitama inimest reaalsusega - disain elukeskkonda ülendades, õilistades ja happening'id - elu formaalseid struktuure lõhkudes. Ka almanahhi "Kunst ja Kodu" erilisest positsioonist lääne kaasaegse kunsti ja disaini tuvustamisel (toimetajaks 1973. aastast Andres Tolts) ning rühmitusest SOUP 1969 ja nende ideoloogide - Ando Keskküla, Andres Toltsi ja Leonhard Lapini tegevusest ja mõjust

Domains of quality of life of people with profound multiple disabilities : The perspective of parents and direct support staff

NARCIS (Netherlands)

Petry, K; Maes, B; Vlaskamp, C

Background This study considered the general validity of the basic domains of quality of life that appear in theoretical models, in relation to people with profound multiple disabilities. The authors examined how parents and direct support staff operationalized these basic domains for people with

Reversal of rocuronium-induced (1.2 mg/kg) profound neuromuscular block by sugammadex: a multicenter, dose-finding and safety study.

NARCIS (Netherlands)

Boer, H.D. de; Driessen, J.J.; Marcus, M.A.; Kerkkamp, H.E.M.; Heeringa, M.; Klimek, M.

2007-01-01

BACKGROUND: Reversal of rocuronium-induced neuromuscular blockade can be accomplished by chemical encapsulation of rocuronium by sugammadex, a modified gamma-cyclodextrin derivative. This study investigated the efficacy and safety of sugammadex in reversing rocuronium-induced profound neuromuscular

Otolithic organ function in patients with profound sensorineural hearing loss

Directory of Open Access Journals (Sweden)

Yujuan Zhou

2016-06-01

Full Text Available Profound sensorineural hearing loss (PSHL is not uncommonly encountered in otology. In clinics, there is a high incidence of otolithic damage in patients with PSHL, but relevant reports are few. Sharing a continuous membranous structure and similar receptor cell ultrastructures, the cochlea and vestibule may be susceptible to the same harmful factors. Disorders of the inner ear may result in a variety of manifestations, including vertigo, spatial disorientation, blurred vision, impaired articulation, and hearing impairment. Considering the diversity of clinical symptoms associated with PSHL with otolithic dysfunction, it may be frequently misdiagnosed, and objective means of testing the function of otolithic organs should be recommended for hearing-impaired patients. Vestibular-evoked myogenic potentials (VEMPs via air-conducted sound are of great importance for the diagnosis of otolithic function. Hearing devices such as cochlear implants are commonly accepted treatments for PSHL, and early identification and treatment of vestibular disorders may increase the success rate of cochlear implantation. Therefore, it is necessary to increase awareness of otolithic functional states in patients with PSHL.

45 CFR 261.56 - What happens if a parent cannot obtain needed child care?

Science.gov (United States)

2010-10-01

... care arrangements are unavailable. (2) Refusal to work when an acceptable form of child care is... child care? 261.56 Section 261.56 Public Welfare Regulations Relating to Public Welfare OFFICE OF FAMILY....56 What happens if a parent cannot obtain needed child care? (a)(1) If the individual is a single...

31 CFR 363.38 - What happens if my financial institution returns an ACH debit?

Science.gov (United States)

2010-07-01

... TreasuryDirect § 363.38 What happens if my financial institution returns an ACH debit? If your designated financial institution returns an ACH debit, we reserve the right to reinitiate the debit at our option. We.... We are not responsible for any fees your financial institution may charge relating to returned ACH...

How musical engagement promotes well-being in education contexts: The case of a young man with profound and multiple disabilities

Science.gov (United States)

McFerran, Katrina S.; Shoemark, Helen

2013-01-01

Students with profound intellectual disabilities disorders (IDDs) have the right to participate in educational opportunities that recognize their unique resources and needs, as do all children. Because of their specific communication challenges, positive relationships with attentive communication partners are critical for success. In fact, the power of positive relationships in schools is recognized to be connected to student well-being more broadly. This article examines the case of one young man with profound IDD and his relationship with his music therapist using a duo-ethnographic informed paradigmatic case study. Video analysis based on multi-voice perspectives is used to generate hermeneutic phenomenological findings to closely examine the relationship between a young man with profound IDD and a music therapist. The voices of four allied health researchers were also gathered to inform the authors’ construction of an informed commentary on the phenomenon. The results suggest that the essence lay in a combination of attentive, responsive and creative being with the other person over time. Four principles of musical engagement were identified in the video footage as critical to the meaningful relationships through music: the music therapist listens; the music therapist takes responsibility for structure; spontaneous initiation is sought from the young person; and the relationship is built over time. These concepts are contextualized within a discussion of student well-being that is underpinned by positive relationships and leads to students achieving their full potential within diverse school contexts. PMID:23930986

How musical engagement promotes well-being in education contexts: the case of a young man with profound and multiple disabilities.

Science.gov (United States)

McFerran, Katrina S; Shoemark, Helen

2013-08-07

Students with profound intellectual disabilities disorders (IDDs) have the right to participate in educational opportunities that recognize their unique resources and needs, as do all children. Because of their specific communication challenges, positive relationships with attentive communication partners are critical for success. In fact, the power of positive relationships in schools is recognized to be connected to student well-being more broadly. This article examines the case of one young man with profound IDD and his relationship with his music therapist using a duo-ethnographic informed paradigmatic case study. Video analysis based on multi-voice perspectives is used to generate hermeneutic phenomenological findings to closely examine the relationship between a young man with profound IDD and a music therapist. The voices of four allied health researchers were also gathered to inform the authors' construction of an informed commentary on the phenomenon. The results suggest that the essence lay in a combination of attentive, responsive and creative being with the other person over time. Four principles of musical engagement were identified in the video footage as critical to the meaningful relationships through music: the music therapist listens; the music therapist takes responsibility for structure; spontaneous initiation is sought from the young person; and the relationship is built over time. These concepts are contextualized within a discussion of student well-being that is underpinned by positive relationships and leads to students achieving their full potential within diverse school contexts.

Examining relationships between staff attributions of soundscapes and core affect in people with severe or profound intellectual and visual disabilities

NARCIS (Netherlands)

van den Bosch, Kirsten A.; Vlaskamp, Carla; Andringa, Tjeerd C.; Post, Wendy J.; Ruijssenaars, Wied A.J.J.M.

Background: People with profound intellectual disabilities experience a high prevalence of visual disabilities, making them more dependent on sound. However, research addressing the influence of the auditory environment is scarce. Method: Observations of the auditory environments (soundscapes) and

Informal social networks of people with profound intellectual and multiple disabilities : Relationship with age, communicative abilities and current living arrangements

NARCIS (Netherlands)

Kamstra, A.; van der Putten, A.A.J.; Post, W.J.; Vlaskamp, C.

2015-01-01

BACKGROUND: People with profound intellectual and multiple disabilities (PIMD) have limited informal social contacts. Research to determine the factors which can positively influence establishing sound informal social contacts is required. MATERIALS AND METHODS: Regression analysis for 200 people

3 CFR 8383 - Proclamation 8383 of May 20, 2009. Emergency Medical Services Week, 2009

Science.gov (United States)

2010-01-01

..., we express our appreciation for their critical work. NOW, THEREFORE, I, BARACK OBAMA, President of... Independence of the United States of America the two hundred and thirty-third.BARACK OBAMA ...

Cancer prevention knowledge of people with profound hearing loss.

Science.gov (United States)

Zazove, Philip; Meador, Helen E; Reed, Barbara D; Sen, Ananda; Gorenflo, Daniel W

2009-03-01

Deaf persons, a documented minority population, have low reading levels and difficulty communicating with physicians. The effect of these on their knowledge of cancer prevention recommendations is unknown. A cross-sectional study of 222 d/Deaf persons in Michigan, age 18 and older, chose one of four ways (voice, video of a certified American Sign Language interpreter, captions, or printed English) to complete a self-administered computer video questionnaire about demographics, hearing loss, language history, health-care utilization, and health-care information sources, as well as family and social variables. Twelve questions tested their knowledge of cancer prevention recommendations. The outcome measures were the percentage of correct answers to the questions and the association of multiple variables with these responses. Participants averaged 22.9% correct answers with no gender difference. Univariate analysis revealed that smoking history, types of medical problems, last physician visit, and women having previous cancer preventive tests did not affect scores. Improved scores occurred with computer use (p = 0.05), higher education (p internet (p = 0.02), and believing that smoking is bad (p bad (p = 0.05) were associated with improved scores. Persons with profound hearing loss have poor knowledge of recommended cancer prevention interventions. English use in multiple settings was strongly associated with increased knowledge.

End-of-life care: nurses' experiences in caring for dying patients with profound learning disabilities--a descriptive case study.

Science.gov (United States)

Li, S; Ng, J

2008-12-01

This qualitative study identifies areas of expertise and deficits in the specific knowledge and practical skills of nurses in the care of dying patients with profound learning disabilities in one NHS Primary Care Trust in the UK. In response to these findings, we have developed a simple observational checklist applicable to profound learning disability nursing to identify disease-related personality and physiological changes. The method consists of a descriptive case study of five nurses qualified in learning disabilities nursing, using semi-structured interviews. The disease trajectory was used as a framework of reference to guide the data analysis. Themes showed were 'certainty of knowing' about disease-related changes in patients' habits and behaviour and 'uncertainty and ambiguity' in the patho-physiology of advanced diseases and disease progression. This study interprets a lack of patho-physiological knowledge in both malignant and non-malignant diseases leading to delayed diagnosis and timely intervention. Timeliness of observation and intervention are emphasised.

The tell-tale: what do heart rate; skin temperature and skin conductance reveal about emotions of people with severe and profound intellectual disabilities?

Science.gov (United States)

Vos, Pieter; De Cock, Paul; Munde, Vera; Petry, Katja; Van Den Noortgate, Wim; Maes, Bea

2012-01-01

Identifying emotions in people with severe and profound intellectual disabilities is a difficult challenge. Since self-reports are not available, behaviour is the most used source of information. Given the limitations and caveats associated with using behaviour as the sole source of information about their emotions, it is important to supplement behavioural information with information from another source. As it is accepted that emotions consist of language, behaviour and physiology, in this article we investigated if physiology could give information about the emotions of people with severe and profound intellectual disabilities. To this aim we tested hypotheses derived from the motivational model of Bradley, Codispoti, Cuthbert, and Lang (2001) about the relation between heart rate and the valence of emotions and between heart rate, skin conductance and skin temperature and behavioural expressions of emotions of people with severe and profound intellectual disability. We presented 27 participants with 4 staff-selected negative and 4 staff-selected positive stimuli. The situations were videotaped and their heart rate, skin conductance and skin temperature was measured. Each behaviour of the participant was coded using the observational method developed by Petry and Maes (2006). As hypothesized, we found a lower heart rate when participants were presented with negative stimuli than when they were presented with positive stimuli in the first 6s of stimuli presentation. Their skin temperature was higher for the expression of low intensity negative emotions compared to the expression of low intensity positive emotions. The results suggest that, as with people without disability, heart rate and skin temperature can give information about the emotions of persons with severe and profound ID. Copyright © 2012 Elsevier Ltd. All rights reserved.

3 CFR 8436 - Proclamation 8436 of October 9, 2009. National School Lunch Week, 2009

Science.gov (United States)

2010-01-01

... week. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, do hereby proclaim... Independence of the United States of America the two hundred and thirty-fourth.BARACK OBAMA ...

3 CFR 8356 - Proclamation 8356 of April 1, 2009. National Donate Life Month, 2009

Science.gov (United States)

2010-01-01

... www.organdonor.gov. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, by... Independence of the United States of America the two hundred and thirty-third.BARACK OBAMA ...

3 CFR 8367 - Proclamation 8367 of April 30, 2009. Law Day, U.S.A., 2009

Science.gov (United States)

2010-01-01

... dedicated to the principles of government under law. NOW, THEREFORE, I, BARACK OBAMA, President of the... Independence of the United States of America the two hundred and thirty-third.BARACK OBAMA ...

Look closer : The alertness of people with profound intellectual and multiple disabilities during multi-sensory storytelling, a time sequential analysis

NARCIS (Netherlands)

Ten Brug, Annet; Munde, Vera S.; van der Putten, Annette A. J.; Vlaskamp, Carla

2015-01-01

Introduction: Multi-sensory storytelling (MSST) is a storytelling method designed for individuals with profound intellectual and multiple disabilities (PIMD). It is essential that listeners be alert during MSST, so that they become familiar with their personalised stories. Repetition and the

Comparison of Irrational Believes between Mothers of Severe or Profound Mentally Handicapped Children with Healthy Children Mothers

Directory of Open Access Journals (Sweden)

Behrouz Hivadi

2007-10-01

Full Text Available Objective: The purpose of present research was the comparison of mothers irrational believes with severe or profound mentally handicapped child and mothers with normal child from 6 to14 years old in Tehran city. Materials & Methods: This study was an analytical, cross – sectional and comparative (case – control research. From mothers with severe or profound mentally handicapped child who had refered to Tehran welfare services centers, 80 mothers were selected by regular randomized sampling from two rehabilitation centers and 80 mothers with normal child were selected for peering with the group of testimonial from schools areas of east, west, south, north and center of Tehran, through multi - stage cluster sampling in for variables of: age of mothers, educational levels, the location of living and the number of children. They answered to questionnaire of irrational believes of jons (IBT. Analysis of data was done by descriptive and infringing statistics methods (Independent T test, U Mann Whitney, Chi-square and fisher. Results: The findings showed that: there are significantly differences in total irrational believes and irrational believes of blame proneness, frustration reactive, anxious over concern, problem avoiding and dependency, perfectionism between two groups of mothers (P<0/05. There was no significant difference in irrational believes between mothers who had mental handicap daughter and mothers who had mental handicap son (P=0/314. There was no significantly difference between two groups of mothers in four believes of demand for approval (P=0/737, high-self expectation (P=0/126, emotional irresponsibility (P=0/727, helplessness for change (p=0/283. Conclusion: Irrational believes and many its sub scales. In mothers of severe or profound mental handicap children were more than mothers with normal child. But believes of demand for approval, high self expectation, emotional irresponsibility, helplessness for change in mothers with

3 CFR 8419 - Proclamation 8419 of September 17, 2009. National POW/MIA Recognition Day, 2009

Science.gov (United States)

2010-01-01

... its service. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, by virtue of... Independence of the United States of America the two hundred and thirty-fourth.BARACK OBAMA ...

13 CFR 127.404 - What happens if SBA is unable to verify a concern's eligibility?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if SBA is unable to verify a concern's eligibility? 127.404 Section 127.404 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES Eligibility Examinations § 127...

Obama's Foreign Policy: Is there such a thing?

OpenAIRE

Pata, Martin

2010-01-01

This thesis examines the foreign policy of the 44th President of the United States of America, Barack Obama. A significant theme of Barack Obama's candidacy for presidency was "change"; more specifically change in policy from previous administration. Therefore, the thesis looks at the changes brought about by President Obama once he was elected. First, we look at foreign policy of the United States under President George W. Bush, then we look at foreign policy-related assertions of Barack Oba...

What happens after a request for euthanasia is refused? Qualitative interviews with patients, relatives and physicians

NARCIS (Netherlands)

Pasman, H.R.W.; Willems, D.L.; Onwuteaka-Philipsen, B.D.

2013-01-01

Objective: Obtaining in-depth information from both patient and physician perspectives about what happens after a request for euthanasia or physician-assisted suicide (EAS) is refused. Methods: In-depth interviews with nine patients whose EAS request was refused and seven physicians of these

On the troubles happened in nuclear power stations, 1995

International Nuclear Information System (INIS)

1996-01-01

The troubles which happened at the nuclear power stations of Japan in the fiscal year of 1995 are described in this report. The number of troubles in those power stations reported from the corporations of electric industry to Nuclear Safety Commission according to The Law for Regulation of Nuclear Fertile Material, Nuclear Fuel Material and Reactors and Utility Industry Law were 14 in the year and so, the number per reactor was 0.3. The details of the trouble cases were as follows; one and nine cases for automatic and manual shutdowns in operation, respectively and 4 cases found during a down-time of the reactor. But, there was no influence on the environment surrounding those nuclear power stations by the radioactive materials in either of the cases. (M.N.)

3 CFR 8433 - Proclamation 8433 of October 2, 2009. Child Health Day, 2009

Science.gov (United States)

2010-01-01

.... NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, by virtue of the authority..., and of the Independence of the United States of America the two hundred and thirty-fourth.BARACK OBAMA ...

Presidendikandidaat Obama tegi algust Euroopa-turneega / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2008-01-01

USA demokraatide presidendikandidaadi Barack Obama visiidist Euroopasse, kohtumisest Saksamaa kantsleri Angela Merkeliga. Barack Obama ei saanud kõnet pidada Brandenburgi värava juures, nagu ta oli soovinud. Lisa: Seni usub rahvas pigem McCaini

Cortical activation in profoundly deaf patients during cochlear implant stimulation demonstrated by H2(15)O PET

International Nuclear Information System (INIS)

Herzog, H.; Lamprecht, A.; Kuehn, A.R.; Roden, W.; Vosteen, K.H.; Feinendegen, L.E.

1991-01-01

Cochlear implants (CIs) are used to provide sensations of sound to profoundly deaf patients. The performance of the CI is assessed mainly by the subjective reports of patients. The aim of this study was to look for objective cortical responses to the stimulation of the CI. Two postlingually and two prelingually deaf patients were investigated by positron emission tomography (PET) using 15 O-labeled water (H 2 15 O) to determine the regional cerebral blood flow (rCBF). Instead of quantifying rCBF in absolute terms, it was estimated by referring the regional tissue concentration of H 2 15 O to the mean whole brain concentration. CI stimulation encoded from white noise and sequential words led to an increased rCBF in the primary and secondary (Wernicke) auditory cortex. Relative elevations of up to 33% were observed bilaterally, although they were higher contralateral to the CI. These results were obtained not only in the postlingually deaf patients but also in two patients who had never been able to hear. Thus, it could be demonstrated that PET measurements of cerebral H 2 15 O distribution yield objective responses of the central auditory system during electrical stimulation by CIs in profoundly deaf patients

PEDAGOGY OF THE HAPPENING: A NON-FORMAL EDUCATIONAL EXPERIENCE FOR REGIONALMUSIC.

Directory of Open Access Journals (Sweden)

Jorge Sossa Santos

2010-02-01

It assumes the Pedagogy of the happening, in order to be in continuous search of elements, situations, images and transformation events up to a point where, after a meeting, things might no longer be the same. It talks about hidden (rhizomatic curriculum and flexible planning, open to the unexpected -so as not to be captured amidst the rigid segmentation of the pedagogical mechanism in music-, and also talks about the appropriation of a body-music, a body-sensitivity and movement, a body-pleasure always ready to enjoy the vibrations of the sonorous, and the aesthetic as a true experience.

3 CFR 8381 - Proclamation 8381 of May 15, 2009. National Safe Boating Week, 2009

Science.gov (United States)

2010-01-01

..., BARACK OBAMA, President of the United States of America, do hereby proclaim May 16 through May 22, 2009..., and of the Independence of the United States of America the two hundred and thirty-third.BARACK OBAMA ...

Informal Social Networks of People with Profound Intellectual and Multiple Disabilities: Relationship with Age, Communicative Abilities and Current Living Arrangements

Science.gov (United States)

Kamstra, A.; van der Putten, A. A. J.; Post, W. J.; Vlaskamp, C.

2015-01-01

Background: People with profound intellectual and multiple disabilities (PIMD) have limited informal social contacts. Research to determine the factors which can positively influence establishing sound informal social contacts is required. Materials and Methods: Regression analysis for 200 people with PIMD was used to analyse how age,…

The Organisation for Economic Co-Operation and Development's International Early Learning Study: What Happened Next

Science.gov (United States)

Moss, Peter; Urban, Mathias

2017-01-01

In this article, the authors provide an update on what has happened over recent months with the Organisation for Economic Co-operation and Development's proposal for an International Early Learning Study, and review responses to the proposed International Early Learning Study, including the concerns that have been raised about this new venture in…

Spider Silk Violin Strings with a Unique Packing Structure Generate a Soft and Profound Timbre

Science.gov (United States)

Osaki, Shigeyoshi

2012-04-01

We overcome the difficulties in pulling long draglines from spiders, twist bundles of dragline filaments, and succeed in preparing violin strings. The twisting is found to change the cross section shapes of filaments from circular to polygonal and to optimize the packing structure with no openings among filaments providing mechanically strong and elastic strings. The spider string signal peaks of overtones for the violin are relatively large at high frequencies, generating a soft and profound timbre. Such a preferable timbre is considered to be due to the unique polygonal packing structure which provides valuable knowledge for developing new types of materials.

The experience of black parents/caretakers with the births and care of a child with profound congenital defects

Directory of Open Access Journals (Sweden)

M.S. Mabaso

1990-09-01

Full Text Available The reaction of Black families to the birth and care of a baby with profound congenital defects was researched using twenty case studies. It was found that the families went through stages of the grieving process, that they shifted from the Western/Christian viewpoint to the traditional viewpoint in their struggle to cope and that they find the existing services grossly inadequate.

Look Closer: The Alertness of People with Profound Intellectual and Multiple Disabilities during Multi-Sensory Storytelling, a Time Sequential Analysis

Science.gov (United States)

Ten Brug, Annet; Munde, Vera S.; van der Putten, Annette A.J.; Vlaskamp, Carla

2015-01-01

Introduction: Multi-sensory storytelling (MSST) is a storytelling method designed for individuals with profound intellectual and multiple disabilities (PIMD). It is essential that listeners be alert during MSST, so that they become familiar with their personalised stories. Repetition and the presentation of stimuli are likely to affect the…

What Happens to a Nursing Home Chain When Private Equity Takes Over? A Longitudinal Case Study

NARCIS (Netherlands)

Bos, A.; Harrington, Charlene

2017-01-01

We analyzed what happens to a nursing home chain when private equity takes over, with regard to strategy, financial performance, and resident well-being. We conducted a longitudinal (2000-2012) case study of a large nursing home chain that triangulated qualitative and quantitative data from 5

3 CFR 8418 - Proclamation 8418 of September 16, 2009. Constitution Day and Citizenship Day, Constitution Week...

Science.gov (United States)

2010-01-01

... as “Constitution Week.” NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America... beacon of hope for Americans and those who seek new lives in the United States. Every day, we welcome new....BARACK OBAMA ...

40 CFR 1068.425 - What happens if one of my production-line engines/equipment exceeds the emission standards?

Science.gov (United States)

2010-07-01

... FOR ENGINE PROGRAMS Selective Enforcement Auditing § 1068.425 What happens if one of my production... engine/equipment to show it complies with all emission standards. (2) Include in your written report a...

Four hospitals in the path of killer tornadoes--what happened before ... during ... after.

Science.gov (United States)

Friedrick, Joanne

2012-01-01

In mid-and late-April, late May, and early June of 2011, tornadoes swept across states in the Midwest, South, Southeast, and even New England, killing hundreds, injuring thousands, destroying property in the billions in both rural and urban areas. Some hospitals in areas where the tornadoes struck did not escape damage and one was destroyed. This article describes what happened at four hospitals in cities hardest hit by the storms and the many roles played by security officers.

Improving Social Skills in Adolescents and Adults with Autism and Severe to Profound Intellectual Disability: A Review of the Literature

Science.gov (United States)

Walton, Katherine M.; Ingersoll, Brooke R.

2013-01-01

Social skills are important treatment targets for individuals with autism spectrum disorders (ASD) across the lifespan. However, few treatments are available for adolescents and adults with ASD who also have severe to profound intellectual disability (S/PID). Several social skill interventions have been described that may improve social skills in…

The Role of the External Personal Assistants for Children with Profound Intellectual and Multiple Disabilities Working in the Children's Home

Science.gov (United States)

Axelsson, Anna Karin

2015-01-01

Background: Children with profound intellectual and multiple disabilities need support to function in an optimal way. However, there is a limited knowledge about the role of external personal assistants working in the children's home. Materials and Methods: A mixed method study was performed including qualitative data from interviews with 11…

41 CFR 102-37.80 - What happens to surplus property that isn't transferred for donation?

Science.gov (United States)

2010-07-01

... property that isn't transferred for donation? 102-37.80 Section 102-37.80 Public Contracts and Property... PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY General Provisions Donation Overview § 102-37.80 What happens to surplus property that isn't transferred for donation? Surplus property not transferred for...

Contemporary America

DEFF Research Database (Denmark)

Duncan, Russell; Goddard, Joseph

Fokuserer på den første administration af Barack Obama og på amerikanske institutioner og folk i USA.......Fokuserer på den første administration af Barack Obama og på amerikanske institutioner og folk i USA....

Managing Profound Suffering at the End-of-Life: Should expanding access to continuous deep sedation be the priority?

Directory of Open Access Journals (Sweden)

Kirby, Jeffrey

2015-01-01

Full Text Available This paper argues that in addressing and managing profound suffering at the end-of-life, the priority should not be the legalization of physician-assisted suicide or voluntary active euthanasia in jurisdictions where these practices are not currently available. Rather, concerted efforts should be made by society and the healthcare provider community to expand patient access to proportionate distress-relieving sedation and continuous deep sedation.

The Hands with Eyes and Nose in the Palm: As Effective Communication Alternatives for Profoundly Deaf People in Zimbabwe

Science.gov (United States)

Mutswanga, Phillipa

2017-01-01

Drawing from the experiences and testimonies of people with profound deafness, the study qualitatively explored the use of the hands with eyes and nose in the palm as communication alternatives in the field of deafness. The study was prompted by the 27 year old lady, Leah Katz-Hernandez who is deaf who got engaged in March 2015 as the 2016…

40 CFR 62.15150 - What happens to the operating requirements during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... requirements during periods of startup, shutdown, and malfunction? 62.15150 Section 62.15150 Protection of... § 62.15150 What happens to the operating requirements during periods of startup, shutdown, and... municipal waste combustion unit startup, shutdown, or malfunction. (b) Each startup, shutdown, or...

Neuro-Oncology Branch Appointment - what happens at the clinical center | Center for Cancer Research

Science.gov (United States)

What Happens When I Get To The Clinical Center at NIH? 1. Visit the Admissions Department Registering is the first step to being evaluated by the Brain Tumor Clinic. Visit Admissions to get registered as a patient. They will ask you for your contact information and provide you with a patient identification number. 2. Proceed to the NOB Clinic Proceed to the Brain Tumor Clinic on the 13th floor.

43 CFR 30.126 - What happens if property was omitted from the inventory of the estate?

Science.gov (United States)

2010-10-01

... the inventory of the estate? 30.126 Section 30.126 Public Lands: Interior Office of the Secretary of the Interior INDIAN PROBATE HEARINGS PROCEDURES Judicial Authority and Duties § 30.126 What happens if property was omitted from the inventory of the estate? This section applies when, after issuance of a...

13 CFR 123.412 - What happens if SBA declines your business' pre-disaster mitigation loan request?

Science.gov (United States)

2010-01-01

...' loan request, SBA will notify your business in writing giving specific reasons for decline. If your... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if SBA declines your business' pre-disaster mitigation loan request? 123.412 Section 123.412 Business Credit and Assistance...

Assumptions of Decision-Making Capacity: The Role Supporter Attitudes Play in the Realisation of Article 12 for People with Severe or Profound Intellectual Disability

Directory of Open Access Journals (Sweden)

Joanne Watson

2016-02-01

Full Text Available The United Nations Convention on the Rights of Persons with Disabilities (UNCRPD was the first legally binding instrument explicitly focused on how human rights apply to people with disability. Amongst their obligations, consistent with the social model of disability, the Convention requires signatory nations to recognise that “…persons with disabilities enjoy legal capacity on an equal basis with others in all aspects of life” and mandates signatory nations to develop “…appropriate measures to provide access by persons with disability to the support they may require in exercising their legal capacity”. The Convention promotes supported decision-making as one such measure. Although Australia ratified the UNCRPD in 2008, it retains an interpretative declaration in relation to Article 12 (2, 3, 4, allowing for the use of substituted decision-making in situations where a person is assessed as having no or limited decision-making capacity. Such an outcome is common for people with severe or profound intellectual disability because the assessments they are subjected to are focused on their cognition and generally fail to take into account the interdependent nature of human decision-making. This paper argues that Australia’s interpretative declaration is not in the spirit of the Convention nor the social model of disability on which it is based. It starts from the premise that the intention of Article 12 is to be inclusive of all signatory nations’ citizens, including those with severe or profound cognitive disability. From this premise, arises a practical need to understand how supported decision-making can be used with this group. Drawing from evidence from an empirical study with five people with severe or profound intellectual disability, this paper provides a rare glimpse on what supported decision-making can look like for people with severe or profound intellectual disability. Additionally, it describes the importance of

The impact of visual impairment on the ability to perform activities of daily living for persons with severe/profound intellectual disability

NARCIS (Netherlands)

Dijkhuizen, Annemarie; Hilgenkamp, Thessa I. M.; Krijnen, Wim P.; Schans, van der Cees P.; Waninge, Aly

Background: The ability to perform activities of daily living (ADL) as a component of participation is one of the factors that contribute to quality of life. The ability to perform ADL for persons experiencing severe/profound intellectual disability (ID) may be reduced due to their cognitive and

Exploring the motor development of young children with possible severe to profound cognitive and motor developmental delay by means of a questionnaire

NARCIS (Netherlands)

Schalen, Gertruud Henrike; van der Putten, Annette; Maes, Bea; Vlaskamp, Carla

Aim: Early motor stimulation may be valuable for children with profound intellectual and multiple disabilities (PIMD), however limited knowledge of their typical motor developmental trajectory may be currently restraining the efficacy and specificity of this intervention. Research on young children

Hypothalamic obesity in patients with craniopharyngioma: Profound changes of several weight regulatory circuits

Directory of Open Access Journals (Sweden)

Christian eRoth

2011-10-01

Full Text Available One of the most striking examples of dysfunctional hypothalamic signaling of energy homeostasis is observed in patients with hypothalamic lesions leading to hypothalamic obesity (HO. This drastic condition is frequently seen in patients with craniopharyngioma (CP, an embryological tumor located in the hypothalamic and/or pituitary region, frequently causing not only hypopituitarism, but also leading to damage of medial hypothalamic nuclei due to the tumor and its treatment. HO syndrome in CP patients is characterized by fatigue, decreased physical activity, uncontrolled appetite, and morbid obesity, and is associated with insulin and leptin resistance. Mechanisms leading to the profoundly disturbed energy homeostasis are complex. This review summarizes different aspects of important clinical studies as well as data obtained in rodent studies. In addition a model is provided describing how medial hypothalamic lesion can interact simultaneously with several weight regulating circuitries.

40 CFR 60.1695 - What happens to the operating requirements during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... requirements during periods of startup, shutdown, and malfunction? 60.1695 Section 60.1695 Protection of... Requirements § 60.1695 What happens to the operating requirements during periods of startup, shutdown, and... municipal waste combustion unit startup, shutdown, or malfunction. (b) Each startup, shutdown, or...

49 CFR 385.333 - What happens at the end of the 18-month safety monitoring period?

Science.gov (United States)

2010-10-01

... SAFETY REGULATIONS SAFETY FITNESS PROCEDURES New Entrant Safety Assurance Program § 385.333 What happens at the end of the 18-month safety monitoring period? (a) If a safety audit has been performed within... the same basis as any other carrier. (d) If a safety audit or compliance review has not been performed...

40 CFR 1051.325 - What happens if an engine family fails the production-line testing requirements?

Science.gov (United States)

2010-07-01

... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.325 What happens if an engine... for an engine family if it fails under § 1051.315. The suspension may apply to all facilities producing vehicles or engines from an engine family, even if you find noncompliant vehicles or engines only...

The impact of visual impairment on the ability to perform activities of daily living for persons with severe/profound intellectual disability

NARCIS (Netherlands)

Dijkhuizen, Annemarie; Hilgenkamp, Thessa I.M.; Krijnen, Wim; van der Schans, Cees; Waninge, Aly

2015-01-01

Background The ability to perform activities of daily living (ADL) as a component of participation is one of the factors that contribute to the quality of life. The ability to perform ADL for persons experiencing severe/profound intellectual disability (ID) may be reduced due to their cognitive and

Transition of International System and China’s Strategic Choice

Institute of Scientific and Technical Information of China (English)

TANG YONGSHENG

2016-01-01

At present,the international situation is at change.The international system undergoes profound transition.Great changes are happening to structure of power pattern,essence of international relations and norms of global governance.Major events of overall and strategic bearings such as the Ukraine Crisis,the Chaos of the Middle East,the proliferation of terrorism and the slowdown in economic

Majanduskriis, vabadussammas, Barack Obama...

Index Scriptorium Estoniae

2008-01-01

Ettevõtja Indrek Neivelt, TLÜ rektor Rein Raud, filmitegija Andres Maimik, peaminister Andrus Ansip, ajakirja Vikerkaar peatoimetaja Märt Väljataga, filmitegija Ilmar Raag avaldavad arvamust, millega läheb 2008. aasta ajalukku

Executive Orders-Barack Obama

Data.gov (United States)

National Archives and Records Administration — Executive orders are official documents, numbered consecutively, through which the President of the United States manages the operations of the Federal Government....

40 CFR 60.1220 - What happens to the emission limits during periods of startup, shutdown, and malfunction?

Science.gov (United States)

2010-07-01

... during periods of startup, shutdown, and malfunction? 60.1220 Section 60.1220 Protection of Environment... Emission Limits § 60.1220 What happens to the emission limits during periods of startup, shutdown, and... waste combustion unit startup, shutdown, or malfunction. (b) Each startup, shutdown, or malfunction must...

3 CFR 8375 - Proclamation 8375 of May 8, 2009. Military Spouse Day, 2009

Science.gov (United States)

2010-01-01

... families. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, by virtue of the... States of America the two hundred and thirty-third.BARACK OBAMA ... spouses work to maintain careers and a sense of community while moving to new duty stations around the...

Efforts in enhancing social contacts of persons with severe of profound intellectual and multiple disabilities : Analysing individual support plans in the Netherlands

NARCIS (Netherlands)

Kamstra, Aafke; van der Putten, Annette; Vlaskamp, Carla

2017-01-01

Most people with profound intellectual and multiple disabilities (PIMD) have limited social contact and it is unclear what is done to maintain or increase these contacts. Individual support planning (ISP) can be used in the systematic enhancement of social contacts. This study analyses the content

Implementation of an Initial Training Program for New Employees in a Profoundly Mentally and Physically Handicapped Children and Adult Residential Facility.

Science.gov (United States)

Hoeft, Linda A.

A project was designed to reduce the turnover of direct care staff in a community-based residential facility that provides a home and educational or adult day training services for 54 severely or profoundly mentally and physically handicapped children and adults. The project sought to reduce total staff turnover by 40%, reduce employee…

Secrets for Survival: The Training Program for Teachers of the Severely/Profoundly Handicapped (S/PH). Description of Teacher Inservice Education Materials.

Science.gov (United States)

National Education Association, Washington, DC. Project on Utilization of Inservice Education R & D Outcomes.

As a description of a "survival kit" for teachers confronted with the instruction of severely/profoundly handicapped children, complete information with regard to purposes of the kit, printed and audiovisual contents, scope and sequencing of topics for the six training modules, and activities and resources involved in the use of the kit is…

3 CFR 8469 - Proclamation 8469 of December 31, 2009. 40th Anniversary of the National Environmental Policy Act...

Science.gov (United States)

2010-01-01

... enjoy the beauty and utility of a clean, healthy planet. NOW, THEREFORE, I, BARACK OBAMA, President of... of America the two hundred and thirty-fourth.BARACK OBAMA Title 3—The President Executive Orders... in a new era of environmental awareness and citizen participation in government. NEPA elevated the...

The Dragon and the Eagle

DEFF Research Database (Denmark)

Duncan, Russell

Fokuserer på komparative og kontrasterende forståelser af kinesisk-amerikanske forbindelser i det 21. århundrede under Xi Jinping og Barack Obama.......Fokuserer på komparative og kontrasterende forståelser af kinesisk-amerikanske forbindelser i det 21. århundrede under Xi Jinping og Barack Obama....

Reversal of rocuronium-induced (1.2 mg kg-1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg-1).

NARCIS (Netherlands)

Molina, A.L.; Boer, H.D. de; Klimek, M.; Heeringa, M.; Klein, J.

2007-01-01

Sugammadex is the first selective relaxant binding agent and reverses rocuronium-induced neuromuscular block. A case is reported in which a patient accidentally received a high dose of sugammadex (40 mg kg-1) to reverse a rocuronium-induced (1.2 mg kg-1) profound neuromuscular block. A fast and

2 CFR 180.345 - What happens if I fail to disclose information required under § 180.335?

Science.gov (United States)

2010-01-01

... Doing Business With Other Persons Disclosing Information-Primary Tier Participants § 180.345 What... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false What happens if I fail to disclose information required under § 180.335? 180.345 Section 180.345 Grants and Agreements OFFICE OF MANAGEMENT AND...

13 CFR 126.308 - What happens if SBA inadvertently omits a qualified HUBZone SBC from the List?

Science.gov (United States)

2010-01-01

... writing at U.S. Small Business Administration, 409 Third Street, SW., Washington, DC 20416 or via e-mail... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if SBA inadvertently omits a qualified HUBZone SBC from the List? 126.308 Section 126.308 Business Credit and Assistance...

USA valimiste võitja võib selguda varakult - kui Obama võtab Indiana / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2008-01-01

USA presidendivalimistel suletakse valimisjaoskonnad esimesena Indianas. Demokraatide kampaania konsultandi Doug Schoeni hinnangul viitab isegi tasavägine tulemus Indianas ilmselt Barack Obama suurele üleriigilisele võidule. Reutersi vaatlejate hinnanguid. Vt. samas: Kas populaarsusküsitlused ikka ennustavad valimistulemuse õigesti? Kaart, tabelid, graafikud: Barack Obama läheb võitma

"But Mine's Better": Teaching History in a Remix Culture

Science.gov (United States)

Kelly, T. Mills

2011-01-01

Everyone who teaches has had moments when students do, say, write, or create something that causes teachers to think about teaching in new ways. Sometimes, it is only with hindsight that they realize just how profound the effect of such moments was. Other times, what happens is so obvious that even if they try they can't ignore the impact it has…

40 CFR 1045.320 - What happens if one of my production-line engines fails to meet emission standards?

Science.gov (United States)

2010-07-01

...-line engines fails to meet emission standards? 1045.320 Section 1045.320 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.320 What happens if one of my...

40 CFR 1048.320 - What happens if one of my production-line engines fails to meet emission standards?

Science.gov (United States)

2010-07-01

...-line engines fails to meet emission standards? 1048.320 Section 1048.320 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.320 What happens if one of my production...

29 CFR 1471.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-07-01

... business with an excluded person, we may disallow costs, annul or terminate the transaction, issue a stop... covered transaction? 1471.325 Section 1471.325 Labor Regulations Relating to Labor (Continued) FEDERAL... of Participants Regarding Transactions Doing Business with Other Persons § 1471.325 What happens if I...

A vascular mechanism to explain thermally mediated variations in deep-body cooling rates during the immersion of profoundly hyperthermic individuals.

Science.gov (United States)

Caldwell, Joanne N; van den Heuvel, Anne M J; Kerry, Pete; Clark, Mitchell J; Peoples, Gregory E; Taylor, Nigel A S

2018-04-01

What is the central question of this study? Does the cold-water immersion (14°C) of profoundly hyperthermic individuals induce reductions in cutaneous and limb blood flow of sufficient magnitude to impair heat loss relative to the size of the thermal gradient? What is the main finding and its importance? The temperate-water cooling (26°C) of profoundly hyperthermic individuals was found to be rapid and reproducible. A vascular mechanism accounted for that outcome, with temperature-dependent differences in cutaneous and limb blood flows observed during cooling. Decisions relating to cooling strategies must be based upon deep-body temperature measurements that have response dynamics consistent with the urgency for cooling. Physiologically trivial time differences for cooling the intrathoracic viscera of hyperthermic individuals have been reported between cold- and temperate-water immersion treatments. One explanation for that observation is reduced convective heat delivery to the skin during cold immersion, and this study was designed to test both the validity of that observation, and its underlying hypothesis. Eight healthy men participated in four head-out water immersions: two when normothermic, and two after exercise-induced, moderate-to-profound hyperthermia. Two water temperatures were used within each thermal state: temperate (26°C) and cold (14°C). Tissue temperatures were measured at three deep-body sites (oesophagus, auditory canal and rectum) and eight skin surfaces, with cutaneous vascular responses simultaneously evaluated from both forearms (laser-Doppler flowmetry and venous-occlusion plethysmography). During the cold immersion of normothermic individuals, oesophageal temperature decreased relative to baseline (-0.31°C over 20 min; P immersed in cold rather than in temperate water (P immersion, whereas pronounced constriction was evident during both immersions when subjects were hyperthermic, with the colder water eliciting a greater vascular

Contemporary America

DEFF Research Database (Denmark)

Duncan, Russell; Goddard, Joseph

This edition analyzes and synthesizes the first administration of Barack Obama and the liberal international and multilateral cosmopolitan approaches to both domestic and foreign policy developments.......This edition analyzes and synthesizes the first administration of Barack Obama and the liberal international and multilateral cosmopolitan approaches to both domestic and foreign policy developments....

22 CFR 1508.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-04-01

... person, we may disallow costs, annul or terminate the transaction, issue a stop work order, debar or... person in a covered transaction? 1508.325 Section 1508.325 Foreign Relations AFRICAN DEVELOPMENT... Regarding Transactions Doing Business with Other Persons § 1508.325 What happens if I do business with an...

2 CFR 180.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-01-01

... person, the Federal agency responsible for your transaction may disallow costs, annul or terminate the... excluded person in a covered transaction? 180.325 Section 180.325 Grants and Agreements OFFICE OF... Regarding Transactions Doing Business With Other Persons § 180.325 What happens if I do business with an...

41 CFR 102-75.170 - What happens to the related personal property in a structure scheduled for demolition?

Science.gov (United States)

2010-07-01

... consideration should be given to designating items having possible historical or artistic value as personal... related personal property in a structure scheduled for demolition? 102-75.170 Section 102-75.170 Public... As Personal Property § 102-75.170 What happens to the related personal property in a structure...

49 CFR 40.303 - What happens if the SAP believes the employee needs additional treatment, aftercare, or support...

Science.gov (United States)

2010-10-01

... recommended services. You may also make use of SAP and employee assistance program (EAP) services in assisting... 49 Transportation 1 2010-10-01 2010-10-01 false What happens if the SAP believes the employee needs additional treatment, aftercare, or support group services even after the employee returns to...

Relabelling behaviour : The effects of psycho-education on the perceived severity and causes of challenging behaviour in people with profound intellectual and multiple disabilities

NARCIS (Netherlands)

Poppes, P.; Putten, van der Annette; Post, W.; Frans, N.; ten Brug, A.; van Es, A.; Vlaskamp, C.

2016-01-01

BackgroundPrevalence rates of challenging behaviour are high in children and adults with profound intellectual and multiple disabilities (PIMD). Moreover, many of these behaviours are observed daily. Direct support staff report that most challenging behaviour identified has little impact on the

Obama reassured Kubilius about U.S. security guarantees / Rokas M. Tracevskis

Index Scriptorium Estoniae

Tracevskis, Rokas M.

2010-01-01

Ameerika Ühendriikide president Barack Obama ja Venemaa riigipea kohtusid 8. aprillil Prahas ning allkirjastasid uue tuumarelvastuse piiramise leppe. Barack Obama oli Prahasse lõunale kutsunud Eesti, Läti, Leedu ja Rumeenia presidendid ning Poola, Tšehhi, Bulgaaria, Horvaatia, Ungari, Slovakkia ja Sloveenia peaministrid. Leedu president Dalia Grybauskaite loobus kutsest, teda asendas peaminister Andrius Kubilius

34 CFR 85.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-07-01

... person, we may disallow costs, annul or terminate the transaction, issue a stop work order, debar or... in a covered transaction? 85.325 Section 85.325 Education Office of the Secretary, Department of... Regarding Transactions Doing Business with Other Persons § 85.325 What happens if I do business with an...

22 CFR 208.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-04-01

... person, we may disallow costs, annul or terminate the transaction, issue a stop work order, debar or... person in a covered transaction? 208.325 Section 208.325 Foreign Relations AGENCY FOR INTERNATIONAL... Regarding Transactions Doing Business with Other Persons § 208.325 What happens if I do business with an...

Simultaneous versus Sequential Intratympanic Steroid Treatment for Severe-to-Profound Sudden Sensorineural Hearing Loss.

Science.gov (United States)

Yoo, Myung Hoon; Lim, Won Sub; Park, Joo Hyun; Kwon, Joong Keun; Lee, Tae-Hoon; An, Yong-Hwi; Kim, Young-Jin; Kim, Jong Yang; Lim, Hyun Woo; Park, Hong Ju

2016-01-01

Severe-to-profound sudden sensorineural hearing loss (SSNHL) has a poor prognosis. We aimed to compare the efficacy of simultaneous and sequential oral and intratympanic steroids for this condition. Fifty patients with severe-to-profound SSNHL (>70 dB HL) were included from 7 centers. The simultaneous group (27 patients) received oral and intratympanic steroid injections for 2 weeks. The sequential group (23 patients) was treated with oral steroids for 2 weeks and intratympanic steroids for the subsequent 2 weeks. Pure-tone averages (PTA) and word discrimination scores (WDS) were compared before treatment and 2 weeks and 1 and 2 months after treatment. Treatment outcomes according to the modified American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) criteria were also analyzed. The improvement in PTA and WDS at the 2-week follow-up was 23 ± 21 dB HL and 20 ± 39% in the simultaneous group and 31 ± 29 dB HL and 37 ± 42% in the sequential group; this was not statistically significant. Complete or partial recovery at the 2-week follow-up was observed in 26% of the simultaneous group and 30% of the sequential group; this was also not significant. The improvement in PTA and WDS at the 2-month follow-up was 40 ± 20 dB HL and 37 ± 35% in the simultaneous group and 41 ± 25 dB HL and 48 ± 41% in the sequential group; this was not statistically significant. Complete or partial recovery at the 2-month follow-up was observed in 33% of the simultaneous group and 35% of the sequential group; this was also not significant. Seven patients in the sequential group did not need intratympanic steroid injections for sufficient improvement after oral steroids alone. Simultaneous oral/intratympanic steroid treatment yielded a recovery similar to that produced by sequential treatment. Because the addition of intratympanic steroids can be decided upon based on the improvement after an oral steroid, the sequential regimen can be recommended to avoid unnecessary

Feasibility, test-retest reliability, and interrater reliability of the Modified Ashworth Scale and Modified Tardieu Scale in persons with profound intellectual and multiple disabilities

NARCIS (Netherlands)

Waninge, A.; Rook, R.A.; Dijkhuizen, A.; Gielen, E.; van der Schans, C.P.

2011-01-01

Caregivers of persons with profound intellectual and multiple disabilities (PIMD) often describe the quality of the daily movements of these persons in terms of flexibility or stiffness. Objective outcome measures for flexibility and stiffness are muscle tone or level of spasticity. Two instruments

The New Leader of the Free World

Science.gov (United States)

Williamson, Kevin D.

2012-01-01

On January 20, 2009, Dr. Manmohan Singh, the prime minister of India, became the leader of the free world. The free world's attention was focused elsewhere: Senator Barack Obama, who on that day became President Barack Obama, quietly abdicated the role now taken up by Dr. Singh, having run an election campaign premised upon the ever-present but…

"To big to fail"-doktrinen står for fald?

DEFF Research Database (Denmark)

Grosen, Anders

2010-01-01

Hvis præsident Barack Obama får sin vilje, skal den klassiske "too big to fail"-bankdoktrin afløses af en "small enough to fail"-doktrin. Det fremgår af præsidentens planer om at opdele storbankerne i mindre enheder og forbyde bankernes handelsaktiviteter for egen regning. Hvis Barack Obama får...

The Obama Books Boom

Science.gov (United States)

Roach, Ronald

2009-01-01

As Barack Obama's rise to power inspires a flood of books, scholars hope the publishing trend will yield serious analysis. Barack Obama's rise from Illinois politics to the U.S. presidency has inspired authors to produce a flood of books chronicling the 44th commander in chief's life story and political career. Obama's political odyssey invites…

21 CFR 1404.325 - What happens if I do business with an excluded person in a covered transaction?

Science.gov (United States)

2010-04-01

... person, we may disallow costs, annul or terminate the transaction, issue a stop work order, debar or... person in a covered transaction? 1404.325 Section 1404.325 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL... Regarding Transactions Doing Business with Other Persons § 1404.325 What happens if I do business with an...

25 CFR 166.819 - What happens if the BIA does not collect enough money to satisfy the penalty?

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What happens if the BIA does not collect enough money to... does not collect enough money to satisfy the penalty? We will send written notice to the trespasser demanding immediate settlement and advising the trespasser that unless settlement is received within five...

What Happened with Spectrometer Magnet 2B

International Nuclear Information System (INIS)

Green, Michael A.

2010-01-01

The spectrometer solenoid is supposed to be the first magnets installed in MICE (1)-(4). This report described what happened during the test of the MICE spectrometer solenoid 2B. First, the report describes the temperatures in the magnet, the cooler top plate and the shield during the run where the magnet quenched at 258 A. During this quench, a lead between the bottom of the HTS leads and the diode bank burned out causing the magnet to quench. Second, three methods for measuring the net heat flow into the cold mass are described. Third, there is a discussion of possible resistive heating in the HTS leads between liquid helium temperature and the copper plate, which is at about 50 K. Fourth, there is a discussion of the measured first stage heat loads in the magnet, when there is no current in the magnet. The first stage heat load calculations are based on knowing the first stage temperatures of the three two-stage pulse tube coolers and the single stage GM cooler. Fifth, the estimated heat load to the first stage when the magnet has current in it is discussed. Sixth, there is a comparison of the stage 1 heat loads in magnet 1A (5), magnet 2A (6), and magnet 2B (7). Finally there is a discussion of recommended changes for improving the spectrometer solenoids so that the coolers can keep them cold.

Triple-loop learning as foundation for profound change, individual cultivation, and radical innovation. Construction processes beyond scientific and rational knowledge.

OpenAIRE

Peschl, Markus F.

2007-01-01

Purpose: Ernst von Glasersfeld’s question concerning the relationship between scientific/ rational knowledge and the domain of wisdom and how these forms of knowledge come about is the starting point. This article aims at developing an epistemological as well as methodological framework that is capable of explaining how profound change can be brought about in various contexts, such as in individual cultivation, in organizations, in processes of radical innovation, etc. This fra...

Nothing Happens by Accident, or Does It? A Low Prior for Randomness Does Not Explain Belief in Conspiracy Theories.

Science.gov (United States)

Dieguez, Sebastian; Wagner-Egger, Pascal; Gauvrit, Nicolas

2015-11-01

Belief in conspiracy theories has often been associated with a biased perception of randomness, akin to a nothing-happens-by-accident heuristic. Indeed, a low prior for randomness (i.e., believing that randomness is a priori unlikely) could plausibly explain the tendency to believe that a planned deception lies behind many events, as well as the tendency to perceive meaningful information in scattered and irrelevant details; both of these tendencies are traits diagnostic of conspiracist ideation. In three studies, we investigated this hypothesis and failed to find the predicted association between low prior for randomness and conspiracist ideation, even when randomness was explicitly opposed to malevolent human intervention. Conspiracy believers' and nonbelievers' perceptions of randomness were not only indistinguishable from each other but also accurate compared with the normative view arising from the algorithmic information framework. Thus, the motto "nothing happens by accident," taken at face value, does not explain belief in conspiracy theories. © The Author(s) 2015.

Relabelling Behaviour. The Effects of Psycho-Education on the Perceived Severity and Causes of Challenging Behaviour in People with Profound Intellectual and Multiple Disabilities

Science.gov (United States)

Poppes, P.; van der Putten, A.; Post, W.; Frans, N.; ten Brug, A.; van Es, A.; Vlaskamp, C.

2016-01-01

Background: Prevalence rates of challenging behaviour are high in children and adults with profound intellectual and multiple disabilities (PIMD). Moreover, many of these behaviours are observed daily. Direct support staff report that most challenging behaviour identified has little impact on the person with PIMD and attribute challenging…

Nanotechnological Inventions and Nanomaterials Produce A Profound Effect

Directory of Open Access Journals (Sweden)

VLASOV Vladimir Alexeevich

2015-02-01

Full Text Available The inventions in the area of nanotechnologies and nanomaterials produce a profound effect in construction, housing and communal services and adjacent economic fields as they allow us: to increase mechanical strength, coefficient of elasticity, alkali resistance and temperature of products vitrification; to obtain nanostructured coatings with the property of shape memory on the steel; to raise the dynamics of coal burning and its full burnout in the boilers of thermoelectric power station; to produce metal nanopowders with increased stored energy 10–15% etc. For example, the invention «Epoxy composition for high strength, alkali resistant structures» refers to epoxy composition used as a binder for production of high strength, thermal- and alkali-resistant glass-fiber material which can be applied in the manufacture process of construction reinforcement to strengthen concrete structures. The invention «The method to produce nanostructured reaction foil» can be used to join different materials including metal alloys, ceramics, amorphous materials and elements of microelectronic devices that are sensible to the heating. This process provides decreased labour-output ratio and energy consumption as well as the condition to manufacture foil with specified stored energy and high mechanical properties. The invention «The method of intensification of burning lowreactionary coal in the boilers of thermoelectric power station» refers to the thermal energy and can be implemented at the thermal plants. The increased dynamics of inflaming and burning leads to full burnout of powdered-coal low-reactionary fuel and decreased mechanical underfiring. The specialists may be also interested in the following inventions: fine dispersed organic suspension of carbon metal-containing nanostructures and the method to produce it; the dispersion of carbon nanotubes; the composition for reinforcement of building structures; the reinforced plate element made of

A Micro-Ethnographic Study of the Communication/Language Development in a Japanese Child with Profound Hearing Loss before and after Cochlear Implantation

Science.gov (United States)

Kretschmer, Richard R.; Kretschmer, Laura; Kuwahara, Katsura; Truax, Roberta

2010-01-01

This study described the communication and spoken language development of a Japanese girl with profound hearing loss who used a cochlear implant from 19 months of age. The girl, Akiko, was born in Belgium where her family was living at that time. After she was identified as deaf at birth, she and her parents were provided with support services.…

Grybauskaite rejects Obama's invitation / Rokas M. Tracevskis

Index Scriptorium Estoniae

Tracevskis, Rokas M.

2010-01-01

8. aprillil kirjutavad Ameerika Ühendriikide president Barack Obama ja Venemaa president Dmitri Medvedev Prahas uuele strateegilise tuumarelvastuse piiramise leppele alla. Samaks päevaks on Barack Obama Prahasse kutsunud Eesti, Läti, Leedu ja Rumeenia presidendid ning Poola, Tšehhi, Bulgaaria, Horvaatia, Ungari, Slovakkia ja Sloveenia peaministrid. Leedu president Dalia Grybauske loobus kutsest. Tema asemel sõidab kohtumisele peaminister Andrius Kubilius

Supporting End of Life Decision Making: Case Studies of Relational Closeness in Supported Decision Making for People with Severe or Profound Intellectual Disability

Science.gov (United States)

Watson, Joanne; Wilson, Erin; Hagiliassis, Nick

2017-01-01

Background: The United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) promotes the use of supported decision making in lieu of substitute decision making. To date, there has been a lack of focus on supported decision making for people with severe or profound intellectual disability, including for end of life decisions.…

Managing a world that not exists never again. Are you ready to fight in the Information Society?

Directory of Open Access Journals (Sweden)

Yordan Sedeño

2007-07-01

Full Text Available While much is new and exciting, many of the changes that seem so profound are actually superficial. The principles of economics and wealth creation endure. However, the new business climate has undermined traditional management practices and it has made the economic management techniques of information technology more relevant than ever before. The bad or lack use of the information nowadays to know all happened, is happening and will happen in a future can drive you to bankrupts. That is why, in the Information Society, how it’s called, all you Information Technology have to work in function to manage all the information that is important for you organization to know all about your environment. The use of the Information technology is very important to keep alive in this competitive business world. For a lot of managers all this is no more than a new “Buzzword”; but this business era has taught us that all them is wrong.

40 CFR 1051.320 - What happens if one of my production-line vehicles or engines fails to meet emission standards?

Science.gov (United States)

2010-07-01

...-line vehicles or engines fails to meet emission standards? 1051.320 Section 1051.320 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM RECREATIONAL ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.320 What happens if one...

42 CFR 137.136 - What happens if the agency takes no action within the 45 day review period (or any extensions...

Science.gov (United States)

2010-10-01

... HUMAN SERVICES TRIBAL SELF-GOVERNANCE Final Offer § 137.136 What happens if the agency takes no action within the 45 day review period (or any extensions thereof)? The final offer is accepted automatically by operation of law. ...

[Inadequacy of the paradigms of special education to subjects with severe and profound grade intellectual disability - the need for pragmatic realism in psychiatry and special pedagogy].

Science.gov (United States)

Sipowicz, Kasper; Żuraw, Hanna; Witusik, Andrzej; Mokros, Łukasz; Najbert, Edyta; Pietras, Tadeusz

2018-05-25

People with severe and profound grade disabilities are the subject of interest in psychiatry, clinical psychology and special pedagogy. Unfortunately, the paradigmatic approach to special education based on postmodern philosophy is in contrast to the biomedical approach that is based on the positivist and Cartesian models. The paper is an attempt to systematize the similarities and differences between the humanistic approach and the modern biomedical model, which, despite the apparent differences, do not differ so much from each other. Work with a person disabled intellectually in the severe or profound degree is governed by the principles of methodical realism, taking into account to an equal extent the principal deficits, the concomitant diseases, limitations and the social context. The deeper the impairment and disability is, the smaller is the role of the humanistic paradigm in work with the client in the medical management and educational process. Changing the paradigms of special pedagogy has drawn attention to the social context of disability, separating, however, special pedagogy from modern medicine and psychology, cognitive-oriented and psychometry-based. The postmodern paradigm has become an ideology, which makes it difficult to work with deeply disabled people. Only the multidirectional approach including a variety of paradigms makes it possible to provide integrational aid to people with severe and profound grade intellectual disabilities. Working with such a disabled person should take into account equally the biomedical and humanistic aspects. © 2018 MEDPRESS.

41 CFR 102-85.205 - What happens if a customer agency continues occupancy after the expiration of an OA?

Science.gov (United States)

2010-07-01

... assignments. However, provisions are necessary to cover the GSA and customer relationship if an OA expires... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What happens if a customer agency continues occupancy after the expiration of an OA? 102-85.205 Section 102-85.205 Public...

Nye koncert-fænomener, Happenings, Action Music etc., Copenhagen, 29-30 August, 3-4 and 6 September 1964

DEFF Research Database (Denmark)

van der Meijden, Peter Alexander

2012-01-01

Artiklen skitserer omstændighederne for tilblivelsen af en Fluxusfestival med titel "Nye koncert-fænomener, happenings, action music etc." som blev afholdt i rammen af Majudstillingen 1964 på Det kongelige danske kunstakademi i København d. 29. og 30. august og d. 3., 4., og 6. september 1964, samt...

Emergent Innovation—a Socio-Epistemological Innovation Technology. Creating Profound Change and Radically New Knowledge as Core Challenges in Knowledge Management

OpenAIRE

Peschl, Markus F.; Fundneider, Thomas

2008-01-01

This paper introduces an alternative approach to innovation: Emergent Innovation. As opposed to radical innovation Emergent Innovation finds a balance and integrates the demand both for radically new knowledge and at the same time for an organic development from within the organization. From a knowledge management perspective one can boil down this problem to the question of how to cope with the new and with profound change in knowledge. This question will be dealt with in the first part of t...

The management of children with Down syndrome and profound hearing loss.

Science.gov (United States)

Phelan, E; Pal, R; Henderson, L; Green, K M J; Bruce, I A

2016-01-01

Although, the association between Down syndrome (DS) and conductive hearing loss is well recognized, the fact that a small proportion of these children may have a severe to profound sensorineural hearing loss that could benefit from cochlear implantation (CI) is less well understood. The management of significant co-morbidities in children with DS can delay initial diagnosis of hearing impairment and assessment of suitability for CI can likewise be challenging, due to difficulties conditioning to behavioural hearing tests. We performed a retrospective case note review of three children with DS referred to the Manchester Cochlear Implant Programme. Three illustrative cases are described including CI in a 4 years old. Using conventional outcome measurement instruments, the outcome could be considered to be suboptimal with a Categories of Auditory Performance score of 4 at 6 months post-op and at last follow up. In part, this is likely to reflect the delay in implantation, but the role of cognitive impairment must be considered. The cases described emphasize the importance of comprehensive radiological and audiological assessment in children with DS being considered for CI. The influence of cognitive impairment upon outcome of CI must be taken into account, but should not be considered a contra-indication to implantation in children with DS. Benefit that might be considered limited when quantified using existing general outcome measurement instruments, may have a significant impact upon psychosocial development and quality of life in children with significant cognitive impairment, or other additional needs.

13 CFR 120.1891 - What happens if an SISMBD is ineligible to receive an SISMBD Loan or an advance?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if an SISMBD is ineligible to receive an SISMBD Loan or an advance? 120.1891 Section 120.1891 Business Credit and Assistance... full upon demand by SBA or SBA will exercise its rights as described in § 120.1830(g). ...

A good read : A study into the use and effects of multi-sensory storytelling; a storytelling method for persons with profound intellectual and multiple disabilities.

NARCIS (Netherlands)

ten Brug, Annet

2015-01-01

In order to include persons with profound intellectual and multiple disabilities (PIMD) into our storytelling culture, multi-sensory storytelling (MSST) has been developed. In a multi-sensory book, verbal text is supported by sensory stimuli, the form and content of the book are adjusted to the

Feasibility, Test-Retest Reliability, and Interrater Reliability of the Modified Ashworth Scale and Modified Tardieu Scale in Persons with Profound Intellectual and Multiple Disabilities

Science.gov (United States)

Waninge, A.; Rook, R. A.; Dijkhuizen, A.; Gielen, E.; van der Schans, C. P.

2011-01-01

Caregivers of persons with profound intellectual and multiple disabilities (PIMD) often describe the quality of the daily movements of these persons in terms of flexibility or stiffness. Objective outcome measures for flexibility and stiffness are muscle tone or level of spasticity. Two instruments used to grade muscle tone and spasticity are the…

The health impacts of women's low control in their living environment: A theory-based systematic review of observational studies in societies with profound gender discrimination.

Science.gov (United States)

Pennington, Andy; Orton, Lois; Nayak, Shilpa; Ring, Adele; Petticrew, Mark; Sowden, Amanda; White, Martin; Whitehead, Margaret

2018-05-01

We conducted a systematic review of observational evidence on the health impacts of women's low control/autonomy in the living environment in societies with profound gender discrimination and gender bias. Thirty observational studies of varying methodological quality were included. Overall, the evidence suggests that women's lower control or autonomy (for example lack of freedom of movement outside the home, lack of authority to access healthcare for sick children) was associated with poorer mental and physical health for women and higher morbidity and mortality for their children, after adjusting for their socioeconomic circumstances. Further studies are needed to disentangle and understand the pathways between low control and health outcomes in contexts of profound gender discrimination. This systematic review has highlighted the general low quality of the evidence base on this research question. It identifies the pressing need for high quality, longitudinal studies in the future. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

31 CFR 363.143 - What happens if an ACH payment used to purchase a certificate of indebtedness is later reversed?

Science.gov (United States)

2010-07-01

... processed security transactions, including securities that were purchased as gifts and securities that have... to purchase a certificate of indebtedness is later reversed? 363.143 Section 363.143 Money and... Indebtedness § 363.143 What happens if an ACH payment used to purchase a certificate of indebtedness is later...

25 CFR 1000.44 - What happens if there are insufficient funds to meet the Tribal requests for planning/negotiation...

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What happens if there are insufficient funds to meet the Tribal requests for planning/negotiation grants in any given year? 1000.44 Section 1000.44 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENT...

Cochlear implantation in autistic children with profound sensorineural hearing loss.

Science.gov (United States)

Lachowska, Magdalena; Pastuszka, Agnieszka; Łukaszewicz-Moszyńska, Zuzanna; Mikołajewska, Lidia; Niemczyk, Kazimierz

2016-11-19

Cochlear implants have become the method of choice for the treatment of severe-to-profound hearing loss in both children and adults. Its benefits are well documented in the pediatric and adult population. Also deaf children with additional needs, including autism, have been covered by this treatment. The aim of this study was to assess the benefits from cochlear implantation in deafened children with autism as the only additional disability. This study analyzes data of six children. The follow-up time was at least 43 months. The following data were analyzed: medical history, reaction to music and sound, Ling's six sounds test, onomatopoeic word test, reaction to spoken child's name, response to requests, questionnaire given to parents, sound processor fitting sessions and data. After cochlear implantation each child presented other communication skills. In some children, the symptoms of speech understanding were observed. No increased hyperactivity associated with daily use cochlear implant was observed. The study showed that in autistic children the perception is very important for a child's sense of security and makes contact with parents easier. Our study showed that oral communication is not likely to be a realistic goal in children with cochlear implants and autism. The implantation results showed benefits that varied among those children. The traditional methods of evaluating the results of cochlear implantation in children with autism are usually insufficient to fully assess the functional benefits. These benefits should be assessed in a more comprehensive manner taking into account the limitations of communication resulting from the essence of autism. It is important that we share knowledge about these complex children with cochlear implants. Copyright © 2016 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

What happened to Larsen C?

Science.gov (United States)

Rignot, E. J.; Larour, E. Y.; Scheuchl, B.; Khazendar, A.; Bamber, J. L.; Mouginot, J.

2017-12-01

In 2017, Larsen C experienced one of the largest calving events in the past century, retreating the ice front by 40 km. The rift that led to this calving event originated decades ago along the flank of Hollick-Kenyon Peninsula and stopped along a suture zone, but started progressing again in 2011 and especially 2014-2015, to eventually lead to the calving of A68. The retreat changed the ice front shape between Bawden Ice Rise and Gibbs Ice Rise from convex to concave, similar to what happened to Larsen B in the late 1990s and Larsen A in the 1980s. Following that retreat, Larsen B eventually collapsed in 2002. The calving is not driven by the traditional processes of viscous bending, hydrofracture, calving cliff failure, longitudinal stress stretching, necking of bottom crevasses joining with surface crevasses, but instead by fracture mechanics. Fracture would be facilitated by the melting of the ice mélange filling the rift, a thinning of the ice shelf, a melting of the heterogeneous marine ice column, or changes in the firn/ice column associated with warming. The ice shelf thinned from the top and below over the last decades; altimetry data from 1994 to 2014 suggesting a decrease in ice shelf thickness of 40-50 m near the zone of rupture. Changes in ocean temperature are relatively undocumented in this part of Antarctica. Air temperature has warmed by 2.4 degrees C over the last 3 decades with a return to colder conditions in recent years yet still much warmer than 30 years ago. We detect no significant change in ice shelf velocity from 2006 to 2017, including after the calving event. The calving front has now retreated within 20-30 km of the compressive arch. We analyze the ice mélange in between the rift with Operation IceBridge laser data from 2009 to 2016 and radio echo sounding data from OIB CreSIS sounder since 2009 to detect changes in ice mélange and marine ice composition. We conclude on how the loss of structural rigidity has lead - or not - to the

Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin.

Science.gov (United States)

Shuvaev, Vladimir V; Kiseleva, Raisa Yu; Arguiri, Evguenia; Villa, Carlos H; Muro, Silvia; Christofidou-Solomidou, Melpo; Stan, Radu V; Muzykantov, Vladimir R

2018-02-28

Inflammatory mediators binding to Toll-Like receptors (TLR) induce an influx of superoxide anion in the ensuing endosomes. In endothelial cells, endosomal surplus of superoxide causes pro-inflammatory activation and TLR4 agonists act preferentially via caveolae-derived endosomes. To test the hypothesis that SOD delivery to caveolae may specifically inhibit this pathological pathway, we conjugated SOD with antibodies (Ab/SOD, size ~10nm) to plasmalemmal vesicle-associated protein (Plvap) that is specifically localized to endothelial caveolae in vivo and compared its effects to non-caveolar target CD31/PECAM-1. Plvap Ab/SOD bound to endothelial cells in culture with much lower efficacy than CD31 Ab/SOD, yet blocked the effects of LPS signaling with higher efficiency than CD31 Ab/SOD. Disruption of cholesterol-rich membrane domains by filipin inhibits Plvap Ab/SOD endocytosis and LPS signaling, implicating the caveolae-dependent pathway(s) in both processes. Both Ab/SOD conjugates targeted to Plvap and CD31 accumulated in the lungs after IV injection in mice, but the former more profoundly inhibited LPS-induced pulmonary inflammation and elevation of plasma level of interferon-beta and -gamma and interleukin-27. Taken together, these results indicate that targeted delivery of SOD to specific cellular compartments may offer effective, mechanistically precise interception of pro-inflammatory signaling mediated by reactive oxygen species. Copyright © 2018 Elsevier B.V. All rights reserved.

13 CFR 120.1892 - What happens if an SISMBD does not use SISMBD Loan funds for a statutorily mandated purpose?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if an SISMBD does not use SISMBD Loan funds for a statutorily mandated purpose? 120.1892 Section 120.1892 Business Credit... the Small Business Act or Pools of such loans, the Administrator shall: (a) Demand immediate repayment...

Black-swan events in animal populations

OpenAIRE

Anderson, Sean C.; Branch, Trevor A.; Cooper, Andrew B.; Dulvy, Nicholas K.

2017-01-01

Black swans?statistically improbable events with profound consequences?happen more often than expected in financial, social, and natural systems. Our work demonstrates the rare but systematic presence of black-swan events in animal populations around the world (mostly birds, mammals, and insects). These events are predominantly downward, implying that unexpected population crashes occur more frequently than increases. Black-swan events are not driven by life history (e.g., lifespan) but by ex...

Do Theory of Mind and Executive Function Deficits Underlie the Adverse Outcomes Associated with Profound Early Deprivation?: Findings from the English and Romanian Adoptees Study

Science.gov (United States)

Colvert, Emma; Rutter, Michael; Kreppner, Jana; Beckett, Celia; Castle, Jenny; Groothues, Christine; Hawkins, Amanda; Stevens, Suzanne; Sonuga-Barke, Edmund J. S.

2008-01-01

Theory of Mind (ToM) and Executive Function (EF) have been associated with autism and with attention-deficit hyperactivity disorder (ADHD), and hence might play a role in similar syndromes found following profound early institutional deprivation. In order to examine this possibility the current study included a group of 165 Romanian adoptees, of…

Prezidentské volby v USA: předvolební kampaň Baracka Obamy

OpenAIRE

Hronová, Lada

2011-01-01

Barack Obama's theme of candidature for President of United States of America, campaigning and then succesfuly won presidential election have became milestone in american history, when the afroamerican president has been elected for the first time. When candidate in primaries with Democratic Party or in final fase of presidental election against his republican competitor John McCain Barack Obama became well admired by american and also world public. Unmistakably important role had common unpo...

Leveraging Trade Agreements to Meet U.S. Security Aims

Science.gov (United States)

2016-04-08

President George H.W. Bush sought means to influence the policies of Latin American states more effectively. Mexico , particularly in the post-Cold War era...security goals. A review of the U.S. trade policy, and its nesting with the National Security Strategy, demonstrates how President Barack Obama’s... President Barack Obama’s strategic “pivot to Asia,” and the Trans-Pacific Partnership (TPP) trade agreement facilitate U.S. enduring national

Obama ja McCaini lugu Ameerika presidendivalimistel : kes võidab? / Jonatan Vseviov

Index Scriptorium Estoniae

Vseviov, Jonatan

2008-01-01

Autor analüüsib USA presidendikandidaatide Barack Obama ja John McCaini valimiskampaaniat, sellel ajal esitatavat lugu minevikust ja tulevikust, kus keskseks tegelaseks on kandidaat ise ning asepresidendikandidaatide valikut. Obamal on muutuste narratiiv - soov muuta senist poliitikat, McCainil aga narratiiv kogemustest ja sõltumatusest. Vt. samas: Barack Obama; John McCain; Hendrik Vosman. Obama valmistub koostama staaride kabinetti; Evelyn Kaldoja. Michelle Obamat võrreldakse Jackie Kennedyga; Missioonitundega õlleprintsess Cindy Hensley McCain

"Everything happens for a reason": children's beliefs about purpose in life events.

Science.gov (United States)

Banerjee, Konika; Bloom, Paul

2015-01-01

Do children believe that "everything happens for a reason?" That is, do children endorse purpose-based, teleological explanations for significant life events, as they do for social behavior, artifacts, biological properties, and natural kinds? Across three experiments, 5- to 7-year-olds (N = 80), 8- to 10-year-olds (N = 72), and adults (N = 91) chose between teleological and nonteleological accounts of significant life events and judged how helpful those accounts were for understanding an event's cause. Five- to 7-year-olds favored teleological explanations, but this preference diminished with age. Five- to 7-year-olds and 8- to 10-year-olds also found teleological explanations more helpful than did adults. Perceiving purpose in life events may therefore have roots in childhood, potentially reflecting a more general sensitivity to purpose in the social and natural worlds. © 2014 The Authors. Child Development © 2014 Society for Research in Child Development, Inc.

36 CFR 51.69 - What happens if there is a dispute between the new concessioner and a prior concessioner as to...

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false What happens if there is a... possessory interest? 51.69 Section 51.69 Parks, Forests, and Public Property NATIONAL PARK SERVICE... possessory interest, the new concessioner must allow the Director to assist the new concessioner in the...

The current status of audiologic rehabilitation for profound unilateral sensorineural hearing loss.

Science.gov (United States)

Bishop, Charles E; Eby, Thomas L

2010-03-01

Audiologic rehabilitation of individuals with profound unilateral sensorineural hearing loss (USNHL) has traditionally been limited to the use of air-conduction contralateral routing of sound (CROS) hearing aids. Treatment for these individuals has expanded with new applications of the bone-anchored hearing aid (BAHA), transcranial hearing aid (t-CROS), and the cochlear implant. In this article, the authors review the literature that addresses these various treatment options. Contemporary review Historical information is available that describes the limited efficacy of air-conduction CROS hearing aids in lifting hearing handicap associated with USNHL. Current investigations on providing cross hearing are generally focused on use of the BAHA. Little is known at present whether new developments in hearing aid technology can improve on conventional air-conduction CROS or t-CROS approaches. Interestingly, the cochlear implant seems to be a viable option for individuals with USNHL and tinnitus who also have intact auditory nerve pathways. There is indication in the literature that BAHA provides greater relief of hearing handicap associated with USNHL than CROS hearing aids; however, both have been found to provide limited patient satisfaction and seemingly fall short of restoring true sound localization. Adequate trials have not been performed comparing BAHA with the best CROS hearing aid technology. Transcranial hearing aids and cochlear implants are experimental methods to treat USNHL and hold promise, although there remains a lack of studies available to fully support this.

Climate change mitigation in the Forest Sector: what Happened in Poznan

International Nuclear Information System (INIS)

Loisel, C.

2008-01-01

Climate change mitigation in the forestry sector was an important topic during the recent Climate Convention conference in Poznan (1- 12 December 2008). Forests appeared in various agenda items of the formal negotiations: - under the Ad Hoc Working Group on Long-term Cooperative Action under the Convention (AWG-LCA) concerning policy approaches and positives incentives on issues relating to reducing emissions from deforestation and forest degradation in developing countries; and the role of conservation, sustainable management of forests and enhancement of forest carbon stocks in developing countries ('REDD+'), - under the Subsidiary Body for Scientific and Technological Advice (SBSTA) concerning methodological aspects on the above, - under the Ad Hoc Working Group on Further Commitments for Annex I Parties under the Kyoto Protocol (AWG-KP) concerning the treatment of greenhouse gas emissions and removals related to land use, land use change and forestry (LULUCF) in Annex I Parties in the context of post-2012 commitments. This note recalls what happened under these agenda items and also on the margins of formal negotiations in relation to climate change mitigation in the forest sector. (author)

THE GLOBAL ZERO MOVEMENT: A ROAD TO NOWHERE

Science.gov (United States)

2016-02-08

persistence.”1 The underlying foundations of the Global Zero movement date back to the 1980s under the Reagan era as noted on the Global Zero website...and his colleagues.7 Presidential Candidate, Barack Obama Supports Global Zero One of those leaders was then Presidential candidate, Barack Obama...movement. In their eyes, this could be chalked up as one of the first major “wins” for the Global Zero movement. 6 As the motivations for Iran

Framing Obama’s Re-election. A Comparative Analysis of German, French and Romanian Media Coverage

Directory of Open Access Journals (Sweden)

Delia Cristina Balaban

2016-04-01

Full Text Available The US presidential election is not only a politically relevant issue but also a media relevant issue in every part of the world. Therefore, the present paper aims to analyze the way print media from Germany, France and Romania comparatively covered the re-election moment of Barack Obama. The research intends to analyze to what degree there are differences between the ways in which print media from the abovementioned countries represented the re-election moment of Barack Obama from the point of view of the framing theory and of the political affiliation of the analyzed newspaper. Moreover, the paper aims to present the way the image of Barack Obama is represented within the pictures used in the media. We expect to find relevant differences both between the analyzed newspapers within a country and between the general perspectives of the selected countries.

Pre-Service Science Teachers' Views on Their Online Argumentation about What Is Happening in Middle School Science Classrooms during Their Practicum Period

Science.gov (United States)

Kaya, Osman Nafiz; Dogan, Alev; Kilic, Ziya; Ebenezer, Jazlin

2004-01-01

In this study, Pre-service Science Teachers' (PSTs) views about the potential benefits and existing barriers of their argumentation on the World Wide Web about what is happening in middle school science classrooms during two semesters of their practicum experiences were investigated. "Special Web Group" called the "Collaborative…

Features of the traffic accidents happened in the province of Aydın between 2005 and 2011.

Science.gov (United States)

Dirlik, Musa; Bostancıoğlu, Başak Çakır; Elbek, Tülay; Korkmaz, Bedir; Çallak Kallem, Füsun; Gün, Berk

2014-09-01

In this study, it was aimed to analyze the traffic accidents with postmortem examinations and autopsies. From the one thousand eight hundred and fifteen forensic autopsies, reports of 334 traffic accidents were searched. Features such as the scene of the accident, type of the accident, type of the vehicles involved in the accident, the year, season, day and hour of the accident, the positions of the victims in the traffic, concomitant orthopedic injuries, whether autopsy was performed, and cause of death were investigated. Among the one thousand eight hundred and fifteen forensic death cases, observed cause of death was determined to be traffic accidents in 334 (18.4%) cases. Male cases accounted 84.1%, and male to female ratio was 5.3 to 1. From the reports, 32.6% of the accidents happened in summer and most commonly during holidays (33%). The rate of the accidents happened in the city center was 35.3% and 32.9% of these cases died due to pedestrian collision. Moreover, it was determined that the most injured person was the driver. Automobiles took the lead in the causes of the traffic accidents. It is realized that traffic accident-related deaths have a substantial place among forensic deaths and continue to be an important public health problem. It is conspicuous that improving public education on traffic safety, increasing traffic management and control measures are of great significance.

49 CFR 385.337 - What happens if a new entrant refuses to permit a safety audit to be performed on its operations?

Science.gov (United States)

2010-10-01

... safety audit to be performed on its operations? 385.337 Section 385.337 Transportation Other Regulations... TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY FITNESS PROCEDURES New Entrant Safety Assurance Program § 385.337 What happens if a new entrant refuses to permit a safety audit to be performed on its...

Partial neuroprotection by nNOS inhibition during profound asphyxia in preterm fetal sheep.

Science.gov (United States)

Drury, Paul P; Davidson, Joanne O; van den Heuij, Lotte G; Tan, Sidhartha; Silverman, Richard B; Ji, Haitao; Blood, Arlin B; Fraser, Mhoyra; Bennet, Laura; Gunn, Alistair Jan

2013-12-01

Preterm brain injury is partly associated with hypoxia-ischemia starting before birth. Excessive nitric oxide production during HI may cause nitrosative stress, leading to cell membrane and mitochondrial damage. We therefore tested the hypothesis that therapy with a new, selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10 (0.022mg/kg bolus, n=8), given 30min before 25min of complete umbilical cord occlusion was protective in preterm fetal sheep at 101-104day gestation (term is 147days), compared to saline (n=8). JI-10 had no effect on fetal blood pressure, heart rate, carotid and femoral blood flow, total EEG power, nuchal activity, temperature or intracerebral oxygenation on near-infrared spectroscopy during or after occlusion. JI-10 was associated with later onset of post-asphyxial seizures compared with saline (p<0.05), and attenuation of the subsequent progressive loss of cytochrome oxidase (p<0.05). After 7days recovery, JI-10 was associated with improved neuronal survival in the caudate nucleus (p<0.05), but not the putamen or hippocampus, and more CNPase positive oligodendrocytes in the periventricular white matter (p<0.05). In conclusion, prophylactic nNOS inhibition before profound asphyxia was associated with delayed onset of seizures, slower decline of cytochrome oxidase and partial white and gray matter protection, consistent with protection of mitochondrial function. © 2013.

Profound tumor-specific Th2 bias in patients with malignant glioma

International Nuclear Information System (INIS)

Shimato, Shinji; Maier, Lisa M; Maier, Richard; Bruce, Jeffrey N; Anderson, Richard CE; Anderson, David E

2012-01-01

Vaccination against tumor-associated antigens is one promising approach to immunotherapy against malignant gliomas. While previous vaccine efforts have focused exclusively on HLA class I-restricted peptides, class II-restricted peptides are necessary to induce CD4 + helper T cells and sustain effective anti-tumor immunity. In this report we investigated the ability of five candidate peptide epitopes derived from glioma-associated antigens MAGE and IL-13 receptor α2 to detect and characterize CD4 + helper T cell responses in the peripheral blood of patients with malignant gliomas. Primary T cell responses were determined by stimulating freshly isolated PBMCs from patients with primary glioblastoma (GBM) (n = 8), recurrent GBM (n = 5), meningioma (n = 7), and healthy controls (n = 6) with each candidate peptide, as well as anti-CD3 monoclonal antibody (mAb) and an immunodominant peptide epitope derived from myelin basic protein (MBP) serving as positive and negative controls, respectively. ELISA was used to measure IFN-γ and IL-5 levels, and the ratio of IFN-γ/IL-5 was used to determine whether the response had a predominant Th1 or Th2 bias. We demonstrate that novel HLA Class-II restricted MAGE-A3 and IL-13Rα2 peptides can detect T cell responses in patients with GBMs as well as in healthy subjects. Stimulation with a variety of peptide antigens over-expressed by gliomas is associated with a profound reduction in the IFN-γ/IL-5 ratio in GBM patients relative to healthy subjects. This bias is more pronounced in patients with recurrent GBMs. Therapeutic vaccine strategies to shift tumor antigen-specific T cell response to a more immunostimulatory Th1 bias may be needed for immunotherapeutic trials to be more successful clinically

Cochlear implantation: is hearing preservation necessary in severe to profound hearing loss?

Science.gov (United States)

Derinsu, Ufuk; Serin, Gediz Murat; Akdaş, Ferda; Batman, Çağlar

2011-03-01

The goal of the cochlear implant surgery is to place the electrode array with minimal damage to preserve the residual hearing. Round-window insertion can be performed in a manner that is potentially less traumatic than the standard cochleostomy. The purpose of the study was to investigate audiological results of the round-window approach using standard electrode. A retrospective study was performed to evaluate our experience in patients with implanted through round window between January 2007 and March 2009. Sixty patients had undergone cochlear implant surgery through the round window with full insertion of a standard electrode array. Preoperative and postoperative pure-tone thresholds were measured for implanted ears in the range of 250 to 4000 Hz. Within these 60 cases, 31 patients had been evaluated. The population comprised 16 women and 15 men. The mean age was 15.96 years (range, 4-64 years). Follow-up times ranged from 6 to 26 months. Preservation of low-frequency hearing (250 and 500 Hz) was achieved in 27 (87%) of 31 patients. Complete hearing preservation (all frequencies) was accomplished in 11 patients (35.48%). No hearing could be determined postoperatively in 4 patients (12.9%), having preoperative thresholds of 120 dB at 250, 500, and 1000 Hz. Round-window approach has been widely used for preservation of residual hearing. In our patients with severe to profound hearing loss, we preserved residual hearing. Although the residual hearing cannot be sufficient for using additional acoustic stimulation, the preserved residual hearing means minimal damage and a more convenient cochlea, so this is promising for future development.

A Glance on Diagnosis and Ttreatment of Profound Fatigue in Multiple Sclerosis

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Mojtaba Azimian

2007-09-01

Full Text Available Multiple Sclerosis (M.S is one of the prevalent diseases of the central nervous system which cause disability in young adults. This appears as neural signs in different parts and various times. The main defect is local deterioration or destruction of myelin tissue in the brain and spinal cord. Profound fatigue is one the most common symptoms of this disease. Because MS is prevalent in middle ages, so the presence of this symptom affects the life and activity of the patient In these ages people have high amount of activities and this functional disorder creates many difficulties for daily works in patient. For this reason, fatigue problem in patients, always, have caught the attention of researchers. Despite numerous studies, still the exact reason for producing fatigue have not been mentioned But several mechanisms have been discussed, such as: autoimmune mechanism of the disease, Involvement and disorder of endocrine system, involvement of central nervous system and de-synchronization of autonom system. Among these, autoimmune mechanism is considered as a main role in producing fatigue. Lack of proper knowledge regarding exact fatigue mechanism several problems in its treatment. Evaluation is the first step for controlling fatigue, which is done through various tests. Clear and proper evaluation can be obtained by these tests. After evaluation, non-drug and finally drug procedures are helpful. In non-drug treatment the focus is on: sport exercises, suitable diet program, identification and improvement of the patient psychotic disorders, energy conservation methods. Finally, the use of drugs such as Amantadine, Pemoline and Modafini is recommended for fatigue treatment.

Classic Bartter syndrome complicated with profound growth hormone deficiency: a case report.

Science.gov (United States)

Adachi, Masanori; Tajima, Toshihiro; Muroya, Koji; Asakura, Yumi

2013-12-30

Classic Bartter syndrome is a salt-wasting tubulopathy caused by mutations in the CLCNKB (chloride channel Kb) gene. Although growth hormone deficiency has been suggested as a cause for persistent growth failure in patients with classic Bartter syndrome, in our opinion the diagnoses of growth hormone deficiency has been unconvincing in some reports. Moreover, Gitelman syndrome seems to have been confused with Bartter syndrome in some cases in the literature. In the present work, we describe a new case with CLCNKB gene mutations and review the reported cases of classic Bartter syndrome associated with growth hormone deficiency. Our patient was a Japanese boy diagnosed as having classic Bartter syndrome at eight months of age. The diagnosis of Bartter syndrome was confirmed by CLCNKB gene analysis, which revealed compound heterozygous mutations with deletion of exons 1 to 3 (derived from his mother) and ΔL130 (derived from his father). His medical therapy consisted of potassium (K), sodium chloride, spironolactone, and anti-inflammatory agents; this regime was started at eight months of age. Our patient was very short (131.1cm, -4.9 standard deviation) at 14.3 years and showed profoundly impaired growth hormone responses to pharmacological stimulants: 0.15μg/L to insulin-induced hypoglycemia and 0.39μg/L to arginine. His growth response to growth hormone therapy was excellent. The present case strengthens the association between classic Bartter syndrome and growth hormone deficiency. We propose that growth hormone status should be considered while treating children with classic Bartter syndrome.

A randomized controlled trial to evaluate the Make Safe Happen® app-a mobile technology-based safety behavior change intervention for increasing parents' safety knowledge and actions.

Science.gov (United States)

McKenzie, Lara B; Roberts, Kristin J; Clark, Roxanne; McAdams, Rebecca; Abdel-Rasoul, Mahmoud; Klein, Elizabeth G; Keim, Sarah A; Kristel, Orie; Szymanski, Alison; Cotton, Christopher G; Shields, Wendy C

2018-03-12

Many unintentional injuries that occur in and around the home can be prevented through the use of safety equipment and by consistently following existing safety recommendations. Unfortunately, uptake of these safety behaviors is unacceptably low. This paper describes the design of the Make Safe Happen® smartphone application evaluation study, which aims to evaluate a mobile technology-based safety behavior change intervention on parents' safety knowledge and actions. Make Safe Happen® app evaluation study is a randomized controlled trial. Participants will be parents of children aged 0-12 years who are recruited from national consumer online survey panels. Parents will complete a pretest survey, and will be randomized to receive the Make Safe Happen® app or a non-injury-related app, and then complete a posttest follow-up survey after 1 week. Primary outcomes are: (1) safety knowledge; (2) safety behaviors; (3) safety device acquisition and use, and (4) behavioral intention to take safety actions. Anticipated study results are presented. Wide-reaching interventions, to reach substantial parent and caregiver audiences, to effectively reduce childhood injuries are needed. This study will contribute to the evidence-base about how to increase safety knowledge and actions to prevent home-related injuries in children. NCT02751203 ; Pre-results.

Convergences

International Nuclear Information System (INIS)

Glashow, S.L.

1976-01-01

These are scattered remarks concerning what is happening to (not in) elementary particle physics. New developments are unfolding with unprecedented speed, so that one does not even attempt to give a comprehensive review at this time. Mostly charm is discussed, both its phenomenology and its impact on belief in quarks, chromodynamics, and unified theories. Beneath the newsworthy experimental discoveries of the last two years lies a quieter and more profound theoretical development: the emergence of a theory of particle physics

Bombing the Tomb: Memorial Portraiture and Street Art in Revolutionary Cairo

OpenAIRE

Main, Kelly Leilani

2015-01-01

Governments have long used public art and monuments to characterize and legitimize their regimes. The production of visual space has profound implications on the psychology of the nation state and the way its citizens relate to their histories. It is curious then, to ask what happens when citizens take control of the visual content of their environment, particularly as it relates to memorializing those who have been killed at the hands of political authority or hegemony. This paper will exami...

Evaluating the Quality of the Interaction between Persons with Profound Intellectual and Multiple Disabilities and Direct Support Staff: A Preliminary Application of Three Observation Scales from Parent-Infant Research

Science.gov (United States)

Hostyn, Ine; Petry, Katja; Lambrechts, Greet; Maes, Bea

2011-01-01

Background: Affective and reciprocal interactions with others are essential for persons with profound intellectual and multiple disabilities (PIMD), but it is a challenge to assess their quality. This study aimed to investigate the usefulness of instruments from parent-infant research to evaluate these interactions. Method: Eighteen videotaped…

Differentiating characteristics of deafblindness and autism in people with congenital deafblindness and profound intellectual disability.

Science.gov (United States)

Hoevenaars-van den Boom, M A A; Antonissen, A C F M; Knoors, H; Vervloed, M P J

2009-06-01

In persons with deafblindness, it is hard to distinguish autism spectrum disorders from several deafblind specific behaviours caused by the dual sensory impairments, especially when these persons are also intellectually disabled. As a result, there is an over-diagnosis of autism in persons who are deafblind leading to unsuitable interventions. Autism as specified by the DSM-IV was studied in 10 persons with congenital deafblindness with profound intellectual disabilities. Behaviours of people with deafblindness and autism (n = 5) and of people with deafblindness without autism (n = 5) were observed in a semi-standardised assessment. All people with deafblindness showed impairments in social interaction, communication and language. In contrast to persons without autism, people with deafblindness and autism showed significantly more impairments in reciprocity of social interaction, quality of initiatives to contact and the use of adequate communicative signals and functions. No differences between the groups were found for quantity and persistence of stereotyped behaviour, quality of play and exploration and adequate problem-solving strategies. This study indicates that there are some possibilities to differentiate autism from behaviours specific for deafblindness. It also confirms the large overlap in overt behaviours between people with deafblindness and persons with autism.

Making Nothing Happen: Yeats, Heidegger, Pessoa, and the Emergence of Post-Romanticism

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James Corby

2012-10-01

Full Text Available Through close readings of the work of two major poets of the twentieth century—W.B. Yeats and Fernando Pessoa—this paper identifies and attempts to make sense of an important shift in European modernism away from a broadly Romantic aesthetic toward what might be called “post-Romanticism.” Taking its cue from W.H. Auden’s “In Memory of W.B. Yeats,” where having stated that “poetry makes nothing happen” he asserts that it survives as “a way of happening,” and drawing on the philosophy of Heidegger and Jean-Luc Nancy, this paper argues that this shift from Romanticism to post-Romanticism hinges on a deep metaphysical reconceptualization of poetry understood as poiesis. In light of this reassessment of the aesthetics and philosophical affinities of poetic modernism, it is argued that post-Romanticism should be understood as offering a modest, salutary, phenomenological re-acquaintance with our involvement with the everyday world, in sharp contrast to the transcendental ambitions of the Romantic aesthetic that preceded it.

20 CFR 408.812 - What happens to your SVB payments if you are not a citizen or national of the United States and...

Science.gov (United States)

2010-04-01

... CERTAIN WORLD WAR II VETERANS Suspensions and Terminations Suspension § 408.812 What happens to your SVB..., we will suspend your SVB payments effective with the first full calendar month you are residing in a... payments. If benefits are otherwise payable, they will be resumed effective with the first day of the first...

A Case of Profound Soft Tissue Infection of Lower Limb Contained Maggots after IV Abuse of Iranian

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Majid Heidary

2016-07-01

Full Text Available Background: Infections include soft tissue infections are notable reason for hospital admission among IDUs, owing to unsterile injection techniques and equipment, contamination of drugs with organisms, and poor hygiene. In present case report a patient with profound limb infection is introduced. Case: A 32 years old man was transferred to the emergency department. He was IDU with Iranian for 3 years. Gangrenous deformity of left lower extremity below the knee was seen. Live maggots were moving around the limb freely. The patient underwent before knee amputation (BKA to remove the infected tissues of the limb. Conclusion: In order to evaluate and treat the serious infectious disease problems, drug abuse treatment programs will need to develop appropriate procedures. It is important that physicians, nurses, and other health care providers become better educated about drug abuse. Workers in drug abuse treatment should be well informed about infectious diseases and other complications of drug abuse.

Disasters can happen to anybody: The case of Korea

International Nuclear Information System (INIS)

Ha, Kyoo-Man

2016-01-01

In Korea, there is a pervasive feeling of invincibility to the point that people and organizations do not believe that disasters can strike them. This has impact on the level of preparedness for disasters. This study aims to delve into how Korea has to change its governmental policies/practices with some private partners' efforts to mitigate disaster risks. A case study was utilized as the major methodology by comparing exclusive management with inclusive management. These two approaches have been comparatively analyzed via four variables, namely the central government, the local governments, the incident commander, and other stakeholders. The major finding is that Korea's practices and policies have to evolve from the current exclusive management into future-oriented inclusive management. Moreover, the importance of communication, cooperation, collaboration, and multi-discipline coordination is discussed. Additionally, the problem of reductionism and equal participation among all stakeholders, as well as the resistance from vested interests, are recognized and elaborated for Korea and the international community. - Highlights: • Only a few stakeholders in Korea believe that disaster can happen to anyone. This study aims to delve into how Korea has to change its current practices to mitigate disaster risks. • To compare exclusive management with inclusive management, we have examined four comparative variables, namely the central government's policy, local government's strategy, the incident commander's post, and other stakeholders' efforts. • The major finding is that Korea's practices and policies have to evolve from the current exclusive management into future-oriented inclusive management.

Disasters can happen to anybody: The case of Korea

Energy Technology Data Exchange (ETDEWEB)

Ha, Kyoo-Man, E-mail: ha1999@hotmail.com

2016-02-15

In Korea, there is a pervasive feeling of invincibility to the point that people and organizations do not believe that disasters can strike them. This has impact on the level of preparedness for disasters. This study aims to delve into how Korea has to change its governmental policies/practices with some private partners' efforts to mitigate disaster risks. A case study was utilized as the major methodology by comparing exclusive management with inclusive management. These two approaches have been comparatively analyzed via four variables, namely the central government, the local governments, the incident commander, and other stakeholders. The major finding is that Korea's practices and policies have to evolve from the current exclusive management into future-oriented inclusive management. Moreover, the importance of communication, cooperation, collaboration, and multi-discipline coordination is discussed. Additionally, the problem of reductionism and equal participation among all stakeholders, as well as the resistance from vested interests, are recognized and elaborated for Korea and the international community. - Highlights: • Only a few stakeholders in Korea believe that disaster can happen to anyone. This study aims to delve into how Korea has to change its current practices to mitigate disaster risks. • To compare exclusive management with inclusive management, we have examined four comparative variables, namely the central government's policy, local government's strategy, the incident commander's post, and other stakeholders' efforts. • The major finding is that Korea's practices and policies have to evolve from the current exclusive management into future-oriented inclusive management.

Effect of dentate gyrus disruption on remembering what happened where

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Min W Jung

2015-06-01

Full Text Available Our previous studies using Bax knockout (Bax-KO mice, in which newly generated granule cells continue to accumulate, disrupting neural circuitry specifically in the dentate gyrus (DG, suggest the involvement of the DG in binding the internally-generated spatial map with sensory information on external landmarks (spatial map-object association in forming a distinct spatial context for each environment. In order to test whether the DG is also involved in binding the internal spatial map with sensory information on external events (spatial map-event association, we tested the behavior of Bax-KO mice in a delayed-non-match-to-place task. Performance of Bax-KO mice was indistinguishable from that of wild-type mice as long as there was no interruption during the delay period (tested up to 5 min, suggesting that on-line maintenance of working memory is intact in Bax-KO mice. However, Bax-KO mice showed profound performance deficits when they were removed from the maze during the delay period (interruption condition with a sufficiently long (65 s delay, suggesting that episodic memory was impaired in Bax-KO mice. Together with previous findings, these results suggest the role of the DG in binding spatial information derived from dead reckoning and nonspatial information, such as external objects and events, in the process of encoding episodic memory.

Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action

International Nuclear Information System (INIS)

Scherzberg, Maria-Christina; Kiehl, Andreas; Zivkovic, Aleksandra; Stark, Holger; Stein, Jürgen; Fürst, Robert; Steinhilber, Dieter; Ulrich-Rückert, Sandra

2015-01-01

(Z)-3,5,4′-Trimethoxystilbene (Z-TMS) is a resveratrol analog with increased antiproliferative activity towards a number of cancer cell lines compared to resveratrol, which has been shown to inhibit tubulin polymerization in vitro. The purpose of this study was to investigate if Z-TMS still shows potential for the prevention of metabolic diseases as known for resveratrol. Cell growth inhibition was determined with IC 50 values for Z-TMS between 0.115 μM and 0.473 μM (resveratrol: 110.7 μM to 190.2 μM). Flow cytometric analysis revealed a G 2 /M arrest after Z-TMS treatment, whereas resveratrol caused S phase arrest. Furthermore, Z-TMS was shown to impair microtubule polymerization. Beneficial effects on lipid accumulation were observed for resveratrol, but not for Z-TMS in an in vitro steatosis model. (E)-Resveratrol was confirmed to elevate cAMP levels, and knockdown of AMPK attenuated the antiproliferative activity, while Z-TMS did not show significant effects in these experiments. SIRT1 and AMPK activities were further measured indirectly via induction of the target gene small heterodimer partner (SHP). Thereby, (E)-resveratrol, but not Z-TMS, showed potent induction of SHP mRNA levels in an AMPK- and SIRT1-dependent manner, as confirmed by knockdown experiments. We provide evidence that Z-TMS does not show beneficial metabolic effects, probably due to loss of activity towards resveratrol target genes. Moreover, our data support previous findings that Z-TMS acts as an inhibitor of tubulin polymerization. These findings confirm that the methylation of resveratrol leads to profound changes in the mode of action, which should be taken into consideration when conducting lead structure optimization approaches. - Highlights: • Methylation of resveratrol leads to profound changes in biologic activity. • Z-TMS does not prevent hepatic steatosis, but inhibits tubulin polymerization. • Resveratrol analog Z-TMS does not influence known targets like PDEs, SIRT1

Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action

Energy Technology Data Exchange (ETDEWEB)

Scherzberg, Maria-Christina; Kiehl, Andreas; Zivkovic, Aleksandra; Stark, Holger [Institute of Pharmaceutical Chemistry, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main (Germany); Stein, Jürgen [Institute of Pharmaceutical Chemistry, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main (Germany); Department of Internal Medicine, Sachsenhausen Hospital, Frankfurt am Main (Germany); Fürst, Robert [Institute of Pharmaceutical Biology, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main (Germany); Steinhilber, Dieter [Institute of Pharmaceutical Chemistry, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main (Germany); Ulrich-Rückert, Sandra, E-mail: sandra.ulrich@em.uni-frankfurt.de [Institute of Pharmaceutical Chemistry, Biozentrum, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main (Germany)

2015-08-15

(Z)-3,5,4′-Trimethoxystilbene (Z-TMS) is a resveratrol analog with increased antiproliferative activity towards a number of cancer cell lines compared to resveratrol, which has been shown to inhibit tubulin polymerization in vitro. The purpose of this study was to investigate if Z-TMS still shows potential for the prevention of metabolic diseases as known for resveratrol. Cell growth inhibition was determined with IC{sub 50} values for Z-TMS between 0.115 μM and 0.473 μM (resveratrol: 110.7 μM to 190.2 μM). Flow cytometric analysis revealed a G{sub 2}/M arrest after Z-TMS treatment, whereas resveratrol caused S phase arrest. Furthermore, Z-TMS was shown to impair microtubule polymerization. Beneficial effects on lipid accumulation were observed for resveratrol, but not for Z-TMS in an in vitro steatosis model. (E)-Resveratrol was confirmed to elevate cAMP levels, and knockdown of AMPK attenuated the antiproliferative activity, while Z-TMS did not show significant effects in these experiments. SIRT1 and AMPK activities were further measured indirectly via induction of the target gene small heterodimer partner (SHP). Thereby, (E)-resveratrol, but not Z-TMS, showed potent induction of SHP mRNA levels in an AMPK- and SIRT1-dependent manner, as confirmed by knockdown experiments. We provide evidence that Z-TMS does not show beneficial metabolic effects, probably due to loss of activity towards resveratrol target genes. Moreover, our data support previous findings that Z-TMS acts as an inhibitor of tubulin polymerization. These findings confirm that the methylation of resveratrol leads to profound changes in the mode of action, which should be taken into consideration when conducting lead structure optimization approaches. - Highlights: • Methylation of resveratrol leads to profound changes in biologic activity. • Z-TMS does not prevent hepatic steatosis, but inhibits tubulin polymerization. • Resveratrol analog Z-TMS does not influence known targets like

NATURE FACILITATES CONNECTION WITH THE PROFOUND SELF: NEEDS, GOALS AND RESOURCE AWARENESS

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Nicoleta Răban-Motounu

2014-11-01

Full Text Available The present study is based on Kaplan and Kaplan’s (1989 theory explaining the restorative effects that nature has on a person’s psychic. According to this theory, nature exerts a “soft fascination” combining the activation of involuntary attention mechanisms with the reflexive awareness, allowing a spontaneous detachment from stress factors and automatic functioning, and also the feeling of compatibility between personal purposes, and the possibilities for action offered by the environment (a sense of meaning. Our objective was to investigate the effects of nature on Self awareness: the immediate, emotional experience; needs awareness and organization; plans for action, and availability of resources, both personal, and external. We conducted an experiment with an experimental group (persons watching a video with life in nature and an active control group (involved in a psychotherapeutic technique focused on confronting and solving personal difficulties by creative means, accompanied by a short psychological analysis. The effects were assessed in terms of “here and now” emotions and available resources according to a self-evaluation scale, and with open-ended questions regarding personal needs and goals. The results showed that, for the experimental group, the relaxation effects and the awareness of long term goals were stronger, while all the other effects were the same as for the control group. The results suggest that indeed, nature helps a person get in contact with her profound Self, allowing the access to both “here and now” basic needs, and also long term goals (inner sources of meaning, the sense of connection between internal tendencies, personal, and external resources, resulting in increased positive emotions, and decreased negative emotions. Nature contemplation may facilitate a meditative state whit all its positive effects.

What will happen to retirement income for 401(k) participants after the market decline?

Science.gov (United States)

VanDerhei, Jack

2010-04-01

This paper uses administrative data from millions of 401(k) participants dating back to 1996 as well as several simulation models to determine 401(k) plans' susceptibility to several alleged limitations as well as its potential for significant retirement wealth accumulation for employees working for employers who have chosen to sponsor these plans. What will happen to 401(k) participants after the 2008 market decline will be largely determined by the extent to which the features of automatic enrollment, automatic escalation of contributions, and automatic investment are allowed to play out. Simulation results suggest that the first two features will significantly improve retirement wealth for the lowest-income quartiles going forward, and the third feature (primarily target-date funds) suggest that a large percentage of those on the verge of retirement would benefit significantly by a reduction of equity concentrations to a more age-appropriate level.

Are Auditory Steady-State Responses Useful to Evaluate Severe-to-Profound Hearing Loss in Children?

Science.gov (United States)

Grasel, Signe Schuster; de Almeida, Edigar Rezende; Beck, Roberto Miquelino de Oliveira; Goffi-Gomez, Maria Valéria Schmidt; Ramos, Henrique Faria; Rossi, Amanda Costa; Koji Tsuji, Robinson; Bento, Ricardo Ferreira; de Brito, Rubens

2015-01-01

To evaluate Auditory Steady-State Responses (ASSR) at high intensities in pediatric cochlear implant candidates and to compare the results to behavioral tests responses. This prospective study evaluated 42 children with suspected severe-to-profound hearing loss, aged from 3 to 72 months. All had absent ABR and OAE responses. ASSR were evoked using binaural single frequency stimuli at 110 dB HL with a 10 dB down-seeking procedure. ASSR and behavioral test results were compared. Forty-two subjects completed both ASSR and behavioral evaluation. Eleven children (26.2%) had bilateral responses. Four (9.5%) showed unilateral responses in at least two frequencies, all confirmed by behavioral results. Overall 61 ASSR responses were obtained, most (37.7%) in 500 Hz. Mean thresholds were between 101.3 and 104.2 dB HL. Among 27 subjects with absent ASSR, fifteen had no behavioral responses. Seven subjects showed behavioral responses with absent ASSR responses. No spurious ASSR responses were observed at 100 or 110 dB HL. ASSR is a valuable tool to detect residual hearing. No false-positive ASSR results were observed among 42 children, but in seven cases with absent ASSR, the test underestimated residual hearing as compared to the behavioral responses.

What happens to the motor theory of perception when the motor system is damaged?

Science.gov (United States)

Stasenko, Alena; Garcea, Frank E; Mahon, Bradford Z

2013-09-01

Motor theories of perception posit that motor information is necessary for successful recognition of actions. Perhaps the most well known of this class of proposals is the motor theory of speech perception, which argues that speech recognition is fundamentally a process of identifying the articulatory gestures (i.e. motor representations) that were used to produce the speech signal. Here we review neuropsychological evidence from patients with damage to the motor system, in the context of motor theories of perception applied to both manual actions and speech. Motor theories of perception predict that patients with motor impairments will have impairments for action recognition. Contrary to that prediction, the available neuropsychological evidence indicates that recognition can be spared despite profound impairments to production. These data falsify strong forms of the motor theory of perception, and frame new questions about the dynamical interactions that govern how information is exchanged between input and output systems.

Strategies that facilitate participation in family activities of children and adolescents with profound intellectual and multiple disabilities: parents' and personal assistants' experiences.

Science.gov (United States)

Axelsson, Anna Karin; Imms, Christine; Wilder, Jenny

2014-01-01

Participation throughout one's life plays a significant role for development and emotional well-being. For this reason, there is a need to identify ways to facilitate participation in family activities for children and adolescents with profound intellectual and multiple disabilities (PIMD). The study design was qualitative and explorative, based on semi structured interviews with 11 parents and 9 personal assistants of children with PIMD. The interviews revealed participation-facilitating strategies relating to the children's/adolescent's proximal environment, such as "Availability and acceptability of the activity", "Good knowledge about the child" and a "A positive attitude of people close to the child", as well as strategies related to the children/adolescents themselves: "Sense of belonging", "Possible for the child/adolescent to understand", "Opportunities to influence" and "Feeling of being needed". Children and adolescents with PIMD are dependent on support obtained through their environment. The identified strategies, individually adapted through awareness and knowledge by the parents and the personal assistants, provide important evidence to assist our understanding in gaining understanding about how to improve participation in family activities of children and adolescents with PIMD. Participation-facilitating strategies related to the child/adolescent and his or her proximal environments are identified to improve participation in children and adolescents with profound intellectual and multiple disabilities (PIMD). Examples of strategies for the child's/adolescents' proximal environment include "good knowledge about the child/adolescent", and, for the child/adolescent, include creating "sense of belonging" and "opportunities to influence". Identifying and making these strategies explicit may assist in enhancing the participation of children and adolescents with PIMD in family activities. People in the child's/adolescent's proximal environment need to set

Attentional processes in interactions between people with profound intellectual and multiple disabilities and direct support staff.

Science.gov (United States)

Hostyn, Ine; Ine, Hostyn; Neerinckx, Heleen; Heleen, Neerinckx; Maes, Bea; Bea, Maes

2011-01-01

Few studies have examined joint attention in interactions with persons with profound intellectual and multiple disabilities (PIMD), despite its important role in high-quality interaction. The purpose of this study is to describe the attention-directing behaviours of persons with PIMD and their direct support staff and the attention episodes resulting from their interactions, and to understand how these variables relate to each other. Video observations of 17 staff-client dyads were coded using partial interval recording. The results showed considerable variation across individuals and dyads. In general, persons with PIMD directed the attention of staff members infrequently. The staff members frequently directed their clients' attention towards a topic of interest but did not often use the tactile modality. Within the staff-client dyad, there was not much joint attention; however, shared attention episodes occurred frequently. Shared attention and joint attention are strongly correlated. A negative correlation was found between clients not using attention-directing behaviours and staff members using tactile methods to direct the attention, and joint attention episodes. This study presents both directions for future research and practical implications. Copyright © 2010 Elsevier Ltd. All rights reserved.

Imigrační politika Evropské unie

OpenAIRE

Rýznarová, Ludmila

2016-01-01

This thesis deals with a topic of immigration policy of the European Union of the 21st century. One cannot write about this topic regardless of the migration wave and refugee crisis that has sparked the debate about EU's immigration policy function - and EU as a whole - in general. The aim of this thesis is to give a reader profound view on the topic of immigration policy of the EU in the context of the immigration crisis, to present reasons why is this happening as well as the consequences, ...

Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans.

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Luc Biedermann

Full Text Available BACKGROUND: The human intestinal microbiota is a crucial factor in the pathogenesis of various diseases, such as metabolic syndrome or inflammatory bowel disease (IBD. Yet, knowledge about the role of environmental factors such as smoking (which is known to influence theses aforementioned disease states on the complex microbial composition is sparse. We aimed to investigate the role of smoking cessation on intestinal microbial composition in 10 healthy smoking subjects undergoing controlled smoking cessation. METHODS: During the observational period of 9 weeks repetitive stool samples were collected. Based on abundance of 16S rRNA genes bacterial composition was analysed and compared to 10 control subjects (5 continuing smokers and 5 non-smokers by means of Terminal Restriction Fragment Length Polymorphism analysis and high-throughput sequencing. RESULTS: Profound shifts in the microbial composition after smoking cessation were observed with an increase of Firmicutes and Actinobacteria and a lower proportion of Bacteroidetes and Proteobacteria on the phylum level. In addition, after smoking cessation there was an increase in microbial diversity. CONCLUSIONS: These results indicate that smoking is an environmental factor modulating the composition of human gut microbiota. The observed changes after smoking cessation revealed to be similar to the previously reported differences in obese compared to lean humans and mice respectively, suggesting a potential pathogenetic link between weight gain and smoking cessation. In addition they give rise to a potential association of smoking status and the course of IBD.

Making a difference? A comparison between multi-sensory and regular storytelling for persons with profound intellectual and multiple disabilities.

Science.gov (United States)

Ten Brug, A; Van der Putten, A A J; Penne, A; Maes, B; Vlaskamp, C

2016-11-01

Multi-sensory storytelling (MSST) was developed to include persons with profound intellectual and multiple disabilities in storytelling culture. In order to increase the listeners' attention, MSST stories are individualised and use multiple sensory stimuli to support the verbal text. In order to determine the value of MSST, this study compared listeners' attention under two conditions: (1) being read MSST books and (2) being read regular stories. A non-randomised control study was executed in which the intervention group read MSST books (n = 45) and a comparison group (n = 31) read regular books. Books were read 10 times during a 5-week period. The 1st, 5th and 10th storytelling sessions were recorded on video in both groups, and the percentage of attention directed to the book and/or stimuli and to the storyteller was scored by a trained and independent rater. Two repeated measure analyses (with the storytelling condition as a between-subject factor and the three measurements as factor) were performed to determine the difference between the groups in terms of attention directed to the book/stimuli (first analysis) and storyteller (second analysis). A further analysis established whether the level of attention changed between the reading sessions and whether there was an interaction effect between the repetition of the book and the storytelling condition. The attention directed to the book and/or the stimuli was significantly higher in the MSST group than in the comparison group. No significant difference between the two groups was found in the attention directed to the storyteller. For MSST stories, most attention was observed during the fifth reading session, while for regular stories, the fifth session gained least attentiveness from the listener. The persons with profound intellectual and multiple disabilities paid more attention to the book and/or stimuli in the MSST condition compared with the regular story telling group. Being more attentive towards

Are Auditory Steady-State Responses Useful to Evaluate Severe-to-Profound Hearing Loss in Children?

Directory of Open Access Journals (Sweden)

Signe Schuster Grasel

2015-01-01

Full Text Available Objective. To evaluate Auditory Steady-State Responses (ASSR at high intensities in pediatric cochlear implant candidates and to compare the results to behavioral tests responses. Methods. This prospective study evaluated 42 children with suspected severe-to-profound hearing loss, aged from 3 to 72 months. All had absent ABR and OAE responses. ASSR were evoked using binaural single frequency stimuli at 110 dB HL with a 10 dB down-seeking procedure. ASSR and behavioral test results were compared. Results. Forty-two subjects completed both ASSR and behavioral evaluation. Eleven children (26.2% had bilateral responses. Four (9.5% showed unilateral responses in at least two frequencies, all confirmed by behavioral results. Overall 61 ASSR responses were obtained, most (37.7% in 500 Hz. Mean thresholds were between 101.3 and 104.2 dB HL. Among 27 subjects with absent ASSR, fifteen had no behavioral responses. Seven subjects showed behavioral responses with absent ASSR responses. No spurious ASSR responses were observed at 100 or 110 dB HL. Conclusion. ASSR is a valuable tool to detect residual hearing. No false-positive ASSR results were observed among 42 children, but in seven cases with absent ASSR, the test underestimated residual hearing as compared to the behavioral responses.

JACoW Decoupling CERN accelerators

CERN Document Server

Dworak, Andrzej

2018-01-01

The accelerator complex at CERN is a living system. Accelerators are being dismantled, upgraded or change their purpose. New accelerators are built. The changes do not happen overnight, but when they happen they may require profound changes across the handling systems. Central timings (CT), responsible for sequencing and synchronization of accelerators, are good examples of such systems. This paper shows how over the past twenty years the changes and new requirements influenced the evolution of the CTs. It describes experience gained from using the Central Beam and Cycle Manager (CBCM) CT model, for strongly coupled accelerators, and how it led to a design of a new Dynamic Beam Negotiation (DBN) model for the AD and ELENA accelerators, which reduces the coupling, increasing accelerator independence. The paper ends with an idea how to merge strong points of both models in order to create a single generic system able to efficiently handle all CERN accelerators and provide more beam time to experiments and LHC.

'Non-vocalization': a phonological error process in the speech of severely and profoundly hearing impaired adults, from the point of view of the theory of phonology as human behaviour.

Science.gov (United States)

Halpern, Orly; Tobin, Yishai

2008-01-01

'Non-vocalization' (N-V) is a newly described phonological error process in hearing impaired speakers. In N-V the hearing impaired person actually articulates the phoneme but without producing a voice. The result is an error process looking as if it is produced but sounding as if it is omitted. N-V was discovered by video recording the speech of two groups, profoundly and severely hearing impaired adults in four elicitation tasks of varying difficulty, and analysing 2065 phonological error processes (substitutions, omissions, and N-V) according to 24 criteria resulting in 49,560 data points. Results, which are discussed in view of the theory 'Phonology as Human Behaviour' (PHB), indicate that: (a) The more communicative the error process was; the more effort was made for its production and the more frequent its distribution; (b) The easier the elicitation task was, the more frequent the use of communicative error processes; c) The more difficult the elicitation task was, the more frequent the use of the relatively less communicative and easier to produce error processes; and d) The process of N-V functioned like a communicative error process for the group of profoundly hearing impaired adults.

An ecological method for the sampling of nonverbal signalling behaviours of young children with profound and multiple learning disabilities (PMLD).

Science.gov (United States)

Atkin, Keith; Lorch, Marjorie Perlman

2016-08-01

Profound and multiple learning disabilities (PMLD) are a complex range of disabilities that affect the general health and well-being of the individual and their capacity to interact and learn. We developed a new methodology to capture the non-symbolic signalling behaviours of children with PMLD within the context of a face-to-face interaction with a caregiver to provide analysis at a micro-level of descriptive detail incorporating the use of the ELAN digital video software. The signalling behaviours of participants in a natural, everyday interaction can be better understood with the use of this innovation in methodology, which is predicated on the ecology of communication. Recognition of the developmental ability of the participants is an integral factor within that ecology. The method presented establishes an advanced account of the modalities through which a child affected by PMLD is able to communicate.

Muutunud, kuid lootuseta / Edward McBride

Index Scriptorium Estoniae

McBride, Edward

2011-01-01

USA presidendivalimiste kampaaniast. President Barack Obama võimalusest saada tagasivalituks, vabariiklaste kandidaatidest Rick Perryst ja Mitt Romneyst. Demokraatide tervishoiureformist ja tervishoiuseadusest

Achieving and sustaining profound institutional change in healthcare: case study using neo-institutional theory.

Science.gov (United States)

Macfarlane, Fraser; Barton-Sweeney, Cathy; Woodard, Fran; Greenhalgh, Trisha

2013-03-01

Change efforts in healthcare sometimes have an ambitious, whole-system remit and seek to achieve fundamental changes in norms and organisational culture rather than (or as well as) restructuring the service. Long-term evaluation of such initiatives is rarely undertaken. We report a secondary analysis of data from an evaluation of a profound institutional change effort in London, England, using a mixed-method longitudinal case study design. The service had received £15 million modernisation funding in 2004, covering multiple organisations and sectors and overseen by a bespoke management and governance infrastructure that was dismantled in 2008. In 2010-11, we gathered data (activity statistics, documents, interviews, questionnaires, site visits) and compared these with data from 2003 to 2008. Data analysis was informed by neo-institutional theory, which considers organisational change as resulting from the material-resource environment and three 'institutional pillars' (regulative, normative and cultural-cognitive), enacted and reproduced via the identities, values and activities of human actors. Explaining the long-term fortunes of the different components of the original programme and their continuing adaptation to a changing context required attention to all three of Scott's pillars and to the interplay between macro institutional structures and embedded human agency. The paper illustrates how neo-institutional theory (which is typically used by academics to theorise macro-level changes in institutional structures over time) can also be applied at a more meso level to inform an empirical analysis of how healthcare organisations achieve change and what helps or hinders efforts to sustain those changes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Policy of George W. Bush administration and Barak Obama first administration towards the Russian Federation and other states of the CIS (2001-2012: a comparative analysis

Directory of Open Access Journals (Sweden)

F. D. Solovey

2017-01-01

Full Text Available The article is devoted to the analysis of policies of the two latest American presidents George W. Bush (2001-2008 and Barack Obama (his fi rst administration, 2009-2012 towards Russian Federation and its neighbors – states of the CIS. The author in detail considers main milestones of this policy, its aims, ways, methods and results. The author highlights and analyzes main reasons of degradation of bilateral relations during George W. Bush presidency and considers positive results of “Reset” policy of fi rst Barack Obama’s administration, at the same time noting their limitation and maintenance of disagreements in a few important problems. Policy of the USA towards Russia and other states of the CIS is considered in broader context of fundamental attitudes in foreign policy of neoconservative Republican George W. Bush’ administration and Democratic Barack Obama’s administration. The author makes the main conclusion that as a whole policy of the Democrats towards the Russian Federation and its neighbors was more reasonable, fl exible and effective and let the United States because of softening of rhetoric and a few small compromises return relations with Russia to constructive cooperation and get from this country assistance in all key areas. But by the end of the fi rst Barack Obama’s term a few negative trends became obvious, and these trends developed during the second term of Obama’s presidency. Post-Soviet area has remained potential “battlefi eld” in relations between the two countries, and later this fact has led to the crisis in Crimea and Ukraine, which continues nowadays.

Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells

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Li CongJun

2006-09-01

Full Text Available Abstract Background Global gene expression profiles of bovine kidney epithelial cells regulated by sodium butyrate were investigated with high-density oligonucleotide microarrays. The bovine microarray with 86,191 distinct 60mer oligonucleotides, each with 4 replicates, was designed and produced with Maskless Array Synthesizer technology. These oligonucleotides represent approximately 45,383 unique cattle sequences. Results 450 genes significantly regulated by butyrate with a median False Discovery Rate (FDR = 0 % were identified. The majority of these genes were repressed by butyrate and associated with cell cycle control. The expression levels of 30 selected genes identified by the microarray were confirmed using real-time PCR. The results from real-time PCR positively correlated (R = 0.867 with the results from the microarray. Conclusion This study presented the genes related to multiple signal pathways such as cell cycle control and apoptosis. The profound changes in gene expression elucidate the molecular basis for the pleiotropic effects of butyrate on biological processes. These findings enable better recognition of the full range of beneficial roles butyrate may play during cattle energy metabolism, cell growth and proliferation, and possibly in fighting gastrointestinal pathogens.

Macroevolutionary consequences of profound climate change on niche evolution in marine molluscs over the past three million years

Science.gov (United States)

Saupe, E.E.; Hendricks, J.R.; Portell, R.W.; Dowsett, Harry J.; Haywood, A. M.; Hunter, S.J.; Lieberman, B.S.

2014-01-01

In order to predict the fate of biodiversity in a rapidly changing world, we must first understand how species adapt to new environmental conditions. The long-term evolutionary dynamics of species' physiological tolerances to differing climatic regimes remain obscure. Here, we unite palaeontological and neontological data to analyse whether species' environmental tolerances remain stable across 3 Myr of profound climatic changes using 10 phylogenetically, ecologically and developmentally diverse mollusc species from the Atlantic and Gulf Coastal Plains, USA. We additionally investigate whether these species' upper and lower thermal tolerances are constrained across this interval. We find that these species' environmental preferences are stable across the duration of their lifetimes, even when faced with significant environmental perturbations. The results suggest that species will respond to current and future warming either by altering distributions to track suitable habitat or, if the pace of change is too rapid, by going extinct. Our findings also support methods that project species' present-day environmental requirements to future climatic landscapes to assess conservation risks.

"Suddenly a Binge Drinking Episode Has Happened to Him": Locus of Control, Notion of Responsibility, Alcoholism and Suicide in the Taz Region, Yamal Nenets Autonomous Okrug

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Kirill V. Istomin

2016-12-01

Full Text Available Although the notion of responsibility is often invoked by mass-media reports, activists and lay people when discussing alcoholism and suicides, anthropological discussions of this topic seem to deliberately avoid the notion. Based on the example of the Taz Nenets of western Sibera, this paper explores how cross-cultural differences in the notion of responsibility, if approached in a non-moralising way, can enrich our understanding of several aspects of the drinking and suicidal behaviours of native northerners. The Nenets seem to believe that both positive and negative events in their lives happen more due to chance or for highly localised reasons that they do not control rather than being caused by their own informed and wilful actions (external locus of control. Particularly, acts of suicide and binge drinking episodes just happen to people and, therefore, people cannot be held responsible for them. This attitude can be a compensatory mechanism for the flat attribution style observed among Nenets in previous studies. It should be taken into account in programs of suicide prevention and the treatment of alcoholism.

Learning to make things happen: Infants' observational learning of social and physical causal events.

Science.gov (United States)

Waismeyer, Anna; Meltzoff, Andrew N

2017-10-01

Infants learn about cause and effect through hands-on experience; however, they also can learn about causality simply from observation. Such observational causal learning is a central mechanism by which infants learn from and about other people. Across three experiments, we tested infants' observational causal learning of both social and physical causal events. Experiment 1 assessed infants' learning of a physical event in the absence of visible spatial contact between the causes and effects. Experiment 2 developed a novel paradigm to assess whether infants could learn about a social causal event from third-party observation of a social interaction between two people. Experiment 3 compared learning of physical and social events when the outcomes occurred probabilistically (happening some, but not all, of the time). Infants demonstrated significant learning in all three experiments, although learning about probabilistic cause-effect relations was most difficult. These findings about infant observational causal learning have implications for children's rapid nonverbal learning about people, things, and their causal relations. Copyright © 2017 Elsevier Inc. All rights reserved.

The fusion reactor wall is getting hot. A challenge towards the future for numerical modelling (4). Chap. 4. What is really happening in the wall?

International Nuclear Information System (INIS)

Murata, Isao; Konno, Chikara

2008-01-01

In fusion plasmas, a lot of fast neutrons with a kinetic energy of 14 MeV are generated through D-T fusion reactions. These neutrons travel deep into the first wall and are absorbed in the blanket through nuclear reactions. In the present chapter, the authors discuss what happens in the blanket with the help of computerized simulation. (T.I.)

Scope and profoundness of environmental assessments. A study in the frame of environmental impact assessments. Strategic environmental assessment and FFH (fauna-flora-habitat) impact assessment under specific consideration of the conflict wind energy - bird protection

International Nuclear Information System (INIS)

Erb, Mareen

2013-01-01

The legal background of environmental impact assessments and the principle regulations and guidelines for this assessment are shortly summarized. The following Issues are discussed in detail: fundamentals of environmental assessments, profoundness and scope in environmental assessments; the conflict wind energy parks and birds.

The language phenomenon human communication from milliseconds to millennia

CERN Document Server

Smith, K

2013-01-01

This volume contains a contemporary, integrated description of the processes of language. These range from fast scales (fractions of a second) to slow ones (over a million years). The contributors, all experts in their fields, address language in the brain, production of sentences and dialogues, language learning, transmission and evolutionary processes that happen over centuries or millenia, the relation between language and genes, the origins of language, self-organization, and language competition and death. The book as a whole will help to show how processes at different scales affect each other, thus presenting language as a dynamic, complex and profoundly human phenomenon.

A liveable city:

DEFF Research Database (Denmark)

Sommerlund, Julie

2014-01-01

is increas- ingly based in and on cities rather than nations, and cities compete for businesses, branding, tourists and talent. In the western world, urbanisation has happened simultane- ously to de-industrialisation, which has opened industrial neighbourhoods and harbours for new uses – often focus- ing......There are over 20 cities world-wide with a population of over 10 million people. We have entered ‘The Millennium of the City’. The growth of urban populations has been accompanied by profound changes of the cities’ economic and social profile and of the cities themselves. The world economy...

Efforts to increase social contact in persons with profound intellectual and multiple disabilities: Analysing individual support plans in the Netherlands.

Science.gov (United States)

Kamstra, Aafke; van der Putten, Annette Aj; Vlaskamp, Carla

2017-06-01

Most people with profound intellectual and multiple disabilities (PIMD) have limited social contact and it is unclear what is done to maintain or increase these contacts. Individual support planning (ISP) can be used in the systematic enhancement of social contacts. This study analyses the content of ISPs with respect to the social contacts of people with PIMD. ISPs for 60 persons with PIMD in the Netherlands were inductively coded and illustrated with quotations. It turned out that every ISP contained information about social contacts. Of all the quotations extracted, 71.2% were about current conditions, 6.2% were about the future and less than 1% concerned actual goals. The social contacts of people with PIMD are mentioned in their ISPs, but this is rarely translated into goals. The results of the current study suggest that attention should be paid to ensuring that professionals understand the importance of social contacts and their application in practice.

Communication strategies and intensive interaction therapy meet the theology of the body: bioethics in dialogue with people with profound disabilities.

Science.gov (United States)

Matthews, Pia

2013-01-01

Academic bioethics does not appear to be interested in communication and its ethical concerns unless communication is to do with issues such as capacity, consent, truth telling and confidentiality. In contrast practitioners are interested in actually communicating with their patients and they are often particularly perplexed when it comes to people with profound disabilities where communication appears disrupted. Although some new and not so new communication strategies, and especially intensive interaction, are available, little has been written on either the ethical concerns these may present or the deeper concepts that underpin them. This article explores the practical applications of some of these communication strategies. By engaging these strategies with theology, and specifically Pope John Paul's Theology of the Body, this article identifies and addresses some significant ethical issues that may arise, notably the risk of dualism and of objectifying the human person. Moreover it provides communication strategies with a rationale that goes beyond practicalities to one based on respect for human dignity, justice and solidarity.

[Long-term clinical course of sequelae in patients with neonatal anoxic encephalopathy resulting in profound mental retardation and motor disturbance].

Science.gov (United States)

Ishizaki, A; Kubota, M; Fueki, N; Shinozaki, M; Kurata, K; Takei, M; Sakamoto, K

1993-01-01

A long-term observation has been made in 58 patients (30 males and 28 females) with severe sequelae of neonatal anoxic encephalopathy. They aged from 8 months to 65 years. All of them had motor disturbances and profound mental retardation. Motor function was improved in 4 patients with aging. In contrast, motor activity deteriorated in 11 cases, of which 4 showed a mental regression. Among them, patients who had originally better motor ability than sitting were likely to deteriorate by uncontrollable epilepsy and/or excessive administration of anticonvulsants. Regression of the patients with worse motor ability like bedridden appeared to attributable hypertonia of muscles and bodily deformation. Fifteen cases showed an exacerbation of general condition which originated predominantly to respiratory distress. Twelve patients died including 6 exacerbated cases. Exacerbation or death may have occurred frequently in specific periods of infancy, adolescence and youth with the patients who showed very low motor function such as bedridden and no locomotion.

What Actually Happens When Granular Materials Deform Under Shear: A Look Within

Science.gov (United States)

Viggiani, C.

2012-12-01

We all know that geomaterials (soil and rock) are composed of particles. However, when dealing with them, we often use continuum models, which ignore particles and make use of abstract variables such stress and strain. Continuum mechanics is the classical tool that geotechnical engineers have always used for their everyday calculations: estimating settlements of an embankment, the deformation of a sheet pile wall, the stability of a dam or a foundation, etc. History tells us that, in general, this works fine. While we are happily ignoring particles, they will at times come back to haunt us. This happens when deformation is localized in regions so small that the detail of the soil's (or rock's) particular structure cannot safely be ignored. Failure is the perfect example of this. Researchers in geomechanics (and more generally in solid mechanics) have long since known that all classical continuum models typically break down when trying to model failure. All sorts of numerical troubles ensue - all of them pointing to a fundamental deficiency of the model: the lack of microstructure. N.B.: the term microstructure doesn't prescribe a dimension (e.g., microns), but rather a scale - the scale of the mechanisms responsible for failure. A possible remedy to this deficiency is represented by the so-called "double scale" models, in which the small scale (the microstructure) is explicitly taken into account. Typically, two numerical problems are defined and solved - one at the large (continuum) scale, and the other at the small scale. This sort of approach requires a link between the two scales, to complete the picture. Imagine we are solving at the small scale a simulation of an assembly of a few grains, for example using the Discrete Element Method, whose results are in turn fed back to the large scale Finite Element simulation. The key feature of a double scale model is that one can inject the relevant physics at the appropriate scale. The success of such a model crucially

Development of Bone-Conducted Ultrasonic Hearing Aid for the Profoundly Deaf: Assessments of the Modulation Type with Regard to Intelligibility and Sound Quality

Science.gov (United States)

Nakagawa, Seiji; Fujiyuki, Chika; Kagomiya, Takayuki

2012-07-01

Bone-conducted ultrasound (BCU) is perceived even by the profoundly sensorineural deaf. A novel hearing aid using the perception of amplitude-modulated BCU (BCU hearing aid: BCUHA) has been developed; however, further improvements are needed, especially in terms of articulation and sound quality. In this study, the intelligibility and sound quality of BCU speech with several types of amplitude modulation [double-sideband with transmitted carrier (DSB-TC), double-sideband with suppressed carrier (DSB-SC), and transposed modulation] were evaluated. The results showed that DSB-TC and transposed speech were more intelligible than DSB-SC speech, and transposed speech was closer than the other types of BCU speech to air-conducted speech in terms of sound quality. These results provide useful information for further development of the BCUHA.

Brasil – Estados Unidos: grandes expectativas, pequenos atritos

Directory of Open Access Journals (Sweden)

Virgílio Caixeta Arraes

2016-12-01

Full Text Available O princípio da administração de Barack Obama, do Partido Democrata, gerou expectativa positiva na América Latina, região desdenhada pelo antecessor, George Bush, do Partido Republicano. Valorizar o continente seria prestigiar o Brasil. Todavia, o relacionamento não foi o esperado, embora sem grandes decepções também. The beginning of Barack Obama´s term produced positive expectations on Latin America, a continent which was ignored by his predecessor, George Bush. To give attention to Latin America implies giving prestige to Brazil.  Nonetheless the real relationship could not meet the expectations, although without causing great deceptions.

Estados Unidos, poder cibernético e a “guerra cibernética: Do Worm Stuxnet ao Malware Flame/Skywiper – e além

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Bernardo Wahl Gonçalves de Araújo Jorge

2012-06-01

Full Text Available Inserido no contexto de um tema emergente nas relações internacionais, os conflitos cibernéticos, este artigo objetiva mostrar como os Estados Unidos, nos governos Bush (filho e Barack Obama, têm usado o poder cibernético, mais especificamente a “guerra cibernética” e a espionagem cibernética, para alcançar alguns objetivos de sua política externa. Inserted in the context of an emerging theme in international relations, cyber conflicts, this article aims to show how the United States, in the Bush (son and Barack Obama governments, have used the cyberpower, specifically "cyberwar" and cyber espionage, to achieve some goals of its foreign policy.

Experience with cochlear implants in Greenlanders with profound hearing loss living in Greenland

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Preben Homøe

2013-08-01

Full Text Available Objective. Cochlear implant (CI treatment was introduced to the world in the 1980s and has become a routine treatment for congenital or acquired severe-to-profound hearing loss. CI treatment requires access to a highly skilled team of ear, nose and throat specialists, audiologists and speech-language pathologists for evaluation, surgery and rehabilitation. In particular, children treated with CI are in need of long-term post-operative auditory training and other follow-up support. Design. The study is retrospective with updated information on present performance. Results. Since 2001, a total of 11 Greenlandic patients living in Greenland have been treated with CI, 7 children and 4 adults. Of these children, 4 use oral communication only and are full-time CI-users, 2 with full-time use of CI are still in progress with use of oral communication, and 1 has not acquired oral language yet, but has started auditory and speech training. Six children attend mainstream public school while one child is in kindergarten. Of the adults, only 1 has achieved good speech perception with full-time use of CI while 3 do not use the CI. Discussion. From an epidemiological point of view, approximately 1–3 children below 6 years are in need of a CI every second year in Greenland often due to sequelae from meningitis, which may cause postinfectious deafness. Screening of new-borns for hearing has been started in Greenland establishing the basis for early diagnosis of congenital hearing impairment and subsequent intervention. The logistics and lack of availability of speech therapists in Greenland hampers possibilities for optimal language and speech therapy of CI patients in Greenland. This study aims at describing the results of CI treatment in Greenlanders and the outcome of the CI operations along with the auditory and speech/language outcomes. Finally, we present a suggestion for the future CI treatment and recommendations for an increased effort in the

RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice.

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Enric Mocholí

Full Text Available Rnd proteins are a subfamily of Rho GTPases involved in the control of actin cytoskeleton dynamics and other cell functions such as motility, proliferation and survival. Unlike other members of the Rho family, Rnd proteins lack GTPase activity and therefore remain constitutively active. We have recently described that RhoE/Rnd3 is expressed in the Central Nervous System and that it has a role in promoting neurite formation. Despite their possible relevance during development, the role of Rnd proteins in vivo is not known. To get insight into the in vivo function of RhoE we have generated mice lacking RhoE expression by an exon trapping cassette. RhoE null mice (RhoE gt/gt are smaller at birth, display growth retardation and early postnatal death since only half of RhoE gt/gt mice survive beyond postnatal day (PD 15 and 100% are dead by PD 29. RhoE gt/gt mice show an abnormal body position with profound motor impairment and impaired performance in most neurobehavioral tests. Null mutant mice are hypoactive, show an immature locomotor pattern and display a significant delay in the appearance of the hindlimb mature responses. Moreover, they perform worse than the control littermates in the wire suspension, vertical climbing and clinging, righting reflex and negative geotaxis tests. Also, RhoE ablation results in a delay of neuromuscular maturation and in a reduction in the number of spinal motor neurons. Finally, RhoE gt/gt mice lack the common peroneal nerve and, consequently, show a complete atrophy of the target muscles. This is the first model to study the in vivo functions of a member of the Rnd subfamily of proteins, revealing the important role of Rnd3/RhoE in the normal development and suggesting the possible involvement of this protein in neurological disorders.

Time use of parents raising children with severe or profound intellectual and multiple disabilities.

Science.gov (United States)

Luijkx, J; van der Putten, A A J; Vlaskamp, C

2017-07-01

Raising children with severe or profound intellectual and multiple disabilities (PIMD) is expected to put extreme pressure on parental time use patterns. The aim of this study was to examine the total time use of mothers and fathers raising children with PIMD and compare it with the time use of parents of typically developing children. Twenty-seven fathers and 30 mothers raising children with PIMD completed a time use diary on a mobile phone or tablet app, as did 66 fathers and 109 mothers of typically developing children. Independent t-tests and Mann-Whitney tests were performed to compare mean time use. There are no differences in the time use of parents of children with PIMD on contracted time (paid work and educational activities) and necessary time (personal care, eating and drinking and sleeping) when compared with parents of typically developing children. There are significant differences between the parents of children with PIMD and the parents of typically developing children in terms of committed time (time for domestic work and the care and supervision of their children) and free time. The mothers of children with PIMD spend significantly less time on domestic work and more time on care and supervision than mothers of typically developing children. This study shows that the parents of children with PIMD have to spend a significant amount of time on care tasks and have on average 1.5 h less free time per day than parents of typically developing children. This is a striking difference, because leisure time can substantially contribute to well-being. Therefore, it is important not only to consider a child with PIMD's support needs but also to identify what parents need to continue their children's daily care and supervision. © 2017 John Wiley & Sons Ltd.

Obama rahustab murelikku Ida-Euroopat / Jürgen Tamme

Index Scriptorium Estoniae

Tamme, Jürgen

2014-01-01

USA president Barack Obama puudutas kohtumistel Brüsselis, lisaks olukorrale Krimmis, Euroopa energiajulgeoleku ja Euroopa riikide kaitsekulutuste teemadele, ka NATO kohaloleku suurendamist Ida- ja Kesk-Euroopas

How decisions happen: focal points and blind spots in interdependent decision making.

Science.gov (United States)

Halevy, Nir; Chou, Eileen Y

2014-03-01

Decision makers often simplify decision problems by ignoring readily available information. The current multimethod research investigated which types of information about interdependence situations are psychologically prominent to decision makers and which tend to go unnoticed. Study 1 used eye-tracking measures to investigate how decision makers allocate their attention in interdependence situations and revealed that individuals fixated on mutual cooperation earlier and longer as compared with alternative combinations of strategies and outcomes. In addition, participants' behavioral cooperation was consistent with their attention allocation. Study 2 introduced a novel information-search paradigm: Participants exchanged yes/no questions and answers to discover which of 25 different games their counterpart chose. Analyzing the contents of participants' questions showed that, consistent with Study 1, participants focused primarily on desirable outcomes and symmetric behavioral choices. Study 3 revealed that outcome desirability is a robust basis of psychological prominence across different types of social relations; in contrast, the psychological prominence of symmetry was moderated by the nature of social relations. Study 4 revealed that whether different bases of psychological prominence directed individuals' attention to the same aspects of the decision-making task moderated the effect of information availability on decision latency and cooperation rates. Taken together, these findings contribute to the mapping of bounded rationality, demonstrate how people think about their interdependence, and enhance our understanding of how decisions happen. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

Kurt Volker: USA peab uue entusiasmiga lahendama vanu probleeme / Kurt Volker ; intervjueerinud Evelyn Kaldoja

Index Scriptorium Estoniae

Volker, Kurt

2009-01-01

USA NATO suursaadik president Barack Obamat ootavatest välispoliitilistset probleemidest, NATO poliitikast Gruusia jt. Ida-Euroopa riikide suhtes, Venemaa ja Ukraina gaasitülist ja suhetest Venemaaga

Muutuste ootus / Adrian Wooldridge

Index Scriptorium Estoniae

Wooldridge, Adrian

2009-01-01

2009. aastal tuleb USA presidendil Barack Obamal vastamisi seista kolme suure probleemiga, milleks on arvukatest valimislubadustest tingitud ülepaisutatud ootused, poliitiline eliit Washingtonis ning oma poliitilise filosoofia kujundamine

What happens when we compare the lifespan distributions of life script events and autobiographical memories of life story events? A cross-cultural study

DEFF Research Database (Denmark)

Zaragoza Scherman, Alejandra; Salgado, Sinué; Shao, Zhifang

Cultural Life Script Theory (Berntsen and Rubin, 2004), provides a cultural explanation of the reminiscence bump: adults older than 40 years remember a significantly greater amount of life events happening between 15 - 30 years of age (Rubin, Rahal, & Poon, 1998), compared to other lifetime periods...... and memories of life story events, we can determine the degree to which the cultural life script serves as a recall template for autobiographical memories, especially of positive life events from adolescence and early adulthood, also known as the reminiscence bump period....

Nothing Happens Until it Happens

DEFF Research Database (Denmark)

Simonsen, Eivind Ortind; Dahl, Mads Ronald

2013-01-01

In this book, the authors discuss the new technologies and challenges of data security, data mining and data management. Topics include clustering algorithms in radiobiology and DNA damage quantification; data mining for searching genomic information; data management in the semantic web; and how...... fragile data security can be when the system architecture, authorization and validation is founded on a personal identification number (PIN). (Imprint: Novinka)...

"Obamacare" vor dem Supreme Court / Guy Beaucamp

Index Scriptorium Estoniae

Beaucamp, Guy

2016-01-01

USA tervishoiureformi ajaloost, 2010. a. ravikindlustusreformist ja USA ülemkohtu otsusest jätta jõusse oluline osa president Barack Obama tervishoiureformist (PPACA), hinnang kohtuotsusele ja võrdlused Saksamaaga

Eesti tervishoid on tõesti hea. Aitäh, USA! / Scott Abel

Index Scriptorium Estoniae

Abel, Scott

2010-01-01

Ameeriklane Scott Abel kirjutab, et president Barack Obama tervishoiureform mõjutab arstiabi ka Eestis. Vastukaja artiklile: Turay, Abdul. Kindla individualismi traditsioon // Postimees (2010) 30. märts, lk. 12

Proua Obama on murdnud nii ilusate kui ka mõjukate nimekirja / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2009-01-01

Hiljutise Gallupi küsitluse andmetel toetab USA presidenti Barack Obamat 69 protsenti ja tema abikaasat Michelle Obamat 72 protsenti küsitlusele vastanuist. Michelle Obama populaarsusest esileedi rollis

JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells.

Science.gov (United States)

Keohane, Clodagh; Kordasti, Shahram; Seidl, Thomas; Perez Abellan, Pilar; Thomas, Nicholas S B; Harrison, Claire N; McLornan, Donal P; Mufti, Ghulam J

2015-10-01

CD4(+) T cells maintain cancer surveillance and immune tolerance. Chronic inflammation has been proposed as a driver of clonal evolution in myeloproliferative neoplasms (MPN), suggesting that T cells play an important role in their pathogenesis. Treatment with JAK inhibitors (JAKi) results in improvements in MPN-associated constitutional symptoms as well as reductions in splenomegaly. However, effects of JAKi on T cells in MPN are not well established and the baseline immune signature remains unclear. We investigated the frequency and function of CD4(+) T cell subsets in 50 MPN patients at baseline as well as during treatment with either ruxolitinib or fedratinib in a subset. We show that CD4(+)  CD127(low)  CD25(high)  FOXP3(+) T regulatory cells are reduced in MPN patients compared to healthy controls and that this decrease is even more pronounced following JAKi therapy. Moreover, we show that after 6 months of treatment the number of T helper (Th)-17 cells increased. We also describe a functional 'silencing' of T helper cells both in vivo and in vitro and a blockade of pro-inflammatory cytokines from these cells. This profound effect of JAKi on T cell function may underlay augmented rates of atypical infections that have been reported with use of these drugs. © 2015 John Wiley & Sons Ltd.

What Really Happened in The Hague? Report on the COP 6. Part I. 13 - 25 November 2000, The Hague, The Netherlands

International Nuclear Information System (INIS)

Buchner, B.K.

2001-06-01

This paper investigates the occurrences at the Sixth Conference of the Parties (CoP) to the 1992 United Nations Framework Convention on Climate Change (UNFCCC) which took place in The Hague, Netherlands, from 13-25 November of 2000. Since the conference did not reach an agreement there exists a broad interest in knowing what really happened during the negotiations. The aim of the analysis is to give greater insight to reasons of the climate talks' failure and to progress made during the negotiations. Following the discussions of the issues surrounding the talks in The Hague, the paper will also look forward as to possible solutions and ideas for an eventual agreement

78 FR 70189 - National Child's Day, 2013

Science.gov (United States)

2013-11-25

... their energy and creativity demand. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of... Lady Michelle Obama's Let's Move! initiative, my Administration is helping children develop habits that...

Obama kavatseb samal ajal kulutada ja kokku hoida / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

USA tulevase presidendi Barack Obama meeskond koostab abipaketti, et luua 2010. aastaks juurde 3,5 mln. töökohta, selleks kuluks 500 mld. dollarit. Hiiglaslikust eelarvedefitsiidist. B. Obama majandusmeeskonnast

Let Obama be Obama! / Toomas Alatalu

Index Scriptorium Estoniae

Alatalu, Toomas, 1942-

2010-01-01

USA politoloogi ja julgeolekueksperdi Zbigniew Brzezinski artiklist "Lootusest julguseni" ajakirjas Foreign Affairs, milles autor lahkab president Barack Obama välispoliitikat. USA Lähis-Ida poliitikast ja USA- Iisraeli suhetest

Family influences on the cognitive development of profoundly deaf children: exploring the effects of socioeconomic status and siblings.

Science.gov (United States)

Macaulay, Catrin E; Ford, Ruth M

2013-10-01

We evaluated the cognitive development of 48 profoundly deaf children from hearing families (born 1994-2002, mean age M = 8.0 years at time of test, none of whom had received early auditory-verbal therapy) as a function of family socioeconomic status and number of siblings. Overall, the deaf children matched a younger group of 47 hearing controls (M = 4.6 years) on verbal ability, theory of mind, and cognitive inhibition. Partial correlations (controlling for age) revealed positive relations in the hearing group between maternal education and inhibition, between number of younger siblings and references to emotions, and between number of close-in-age siblings and references to desires and false beliefs. In the deaf group, there were positive relations between household income and memory span, between maternal education and references to false beliefs, and between number of younger siblings and nonverbal ability. In contrast, deaf children with a greater number of older siblings aged ≤12 years showed inferior memory span, inhibition, belief understanding, picture-sequencing accuracy, and mental-state language, suggesting that they failed to compete successfully with older siblings for their parents' attention and material resources. We consider the implications of the findings for understanding birth-order effects on deaf and language-impaired children.

Systematic Moiety Variations of Ultrashort Peptides Produce Profound Effects on Self-Assembly, Nanostructure Formation, Hydrogelation, and Phase Transition

KAUST Repository

Chan, Kiat Hwa

2017-10-04

Self-assembly of small biomolecules is a prevalent phenomenon that is increasingly being recognised to hold the key to building complex structures from simple monomeric units. Small peptides, in particular ultrashort peptides containing up to seven amino acids, for which our laboratory has found many biomedical applications, exhibit immense potential in this regard. For next-generation applications, more intricate control is required over the self-assembly processes. We seek to find out how subtle moiety variation of peptides can affect self-assembly and nanostructure formation. To this end, we have selected a library of 54 tripeptides, derived from systematic moiety variations from seven tripeptides. Our study reveals that subtle structural changes in the tripeptides can exert profound effects on self-assembly, nanostructure formation, hydrogelation, and even phase transition of peptide nanostructures. By comparing the X-ray crystal structures of two tripeptides, acetylated leucine-leucine-glutamic acid (Ac-LLE) and acetylated tyrosine-leucine-aspartic acid (Ac-YLD), we obtained valuable insights into the structural factors that can influence the formation of supramolecular peptide structures. We believe that our results have major implications on the understanding of the factors that affect peptide self-assembly. In addition, our findings can potentially assist current computational efforts to predict and design self-assembling peptide systems for diverse biomedical applications.

Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression

International Nuclear Information System (INIS)

Patrick, Brad; Li Jie; Jeyabal, Prince V.S.; Reddy, Prasada M.R.V.; Yang Yusong; Sharma, Rajendra; Sinha, Mala; Luxon, Bruce; Zimniak, Piotr; Awasthi, Sanjay; Awasthi, Yogesh C.

2005-01-01

Previously, we have shown that overexpression of 4-hydroxy-2-nonenal (HNE)-detoxifying enzyme glutathione S-transferase A4-4 (hGSTA4-4) in human lens epithelial cells (HLE B-3) leads to pro-carcinogenic phenotypic transformation of these cells [R. Sharma, et al. Eur. J. Biochem. 271 (2004) 1960-1701]. We now demonstrate that hGSTA4-transfection also causes a profound change in the expression of genes involved in cell adhesion, cell cycle control, proliferation, cell growth, and apoptosis, which is consistent with phenotypic changes of the transformed cells. The expression of p53, p21, p16, fibronectin 1, laminin γ1, connexin 43, Fas, integrin α6, TGFα, and c-jun was down-regulated, while the expression of protein kinase C beta II (PKCβII), c-myc, cyclin-dependent kinase 2 (CDK2), and TGFβ was up-regulated in transfected cells. These results demonstrate that HNE serves as a crucial signaling molecule and, by modulating the expression of genes, can influence cellular functions

A guerra como instrumento do poder presidencial nos EUA: o caso da intervenção na Líbia

Directory of Open Access Journals (Sweden)

Cláudio Júnior Damin

2012-08-01

Full Text Available Analisa-se a decisão da participação dos EUA na intervenção militar na Líbia em 2011. O objetivo central é posicionar a decisão de Barack Obama de utilizar as forças armadas como um exercício dos poderes de guerra do presidente enquanto comandante-em-chefe e como executor de deliberações de órgãos multilaterais internacionais.   We analyze the decision of U.S. participation in military intervention in Libya (2011. The main objective is to position Barack Obama's decision to use the military as an exercise of war powers of the president as commander in chief and as a doer of the deliberations of international multilateral agencies.

Bright boys the making of information technology

CERN Document Server

Green, Tom

2010-01-01

Everything has a beginning. None was more profound-and quite as unexpected-than Information Technology. Here for the first time is the untold story of how our new age came to be and the bright boys who made it happen. What began on the bare floor of an old laundry building eventually grew to rival in size the Manhattan Project. The unexpected consequence of that journey was huge---what we now know as Information Technology. For sixty years the bright boys have been totally anonymous while their achievements have become a way of life for all of us. "Bright Boys" brings them home. By 1950 they'd

Analysis on natural gas geo-politics in Central Asia-Russia region

Energy Technology Data Exchange (ETDEWEB)

Feng, Dan

2010-09-15

In the year of 2009, some events happened in Central Asia-Russia Region. The transit countries of Nabucco pipeline signed the agreement and the project received considerable progress. The China-Turkmenistan pipeline achieved the completion of ventilation. All these could be landmarks in Central Asia-Russia's geo-political situation. Diversification strategy of gas imports in Europe and diversification strategy of export in Central Asia have been effectively promoted, and the relationship between China and Central Asia becomes closer. Now, the new supply pattern of the region is coming into being and the nature gas geo-political situation in the region is undergoing profound changes.

Comparison of swallowing outcomes of laryngotracheal separation versus total laryngectomy in a validated ovine model of profound oropharyngeal dysphagia.

Science.gov (United States)

Venkatesan, N N; Johnson, C M; Siddiqui, M T; Cates, D J; Kuhn, M A; Postma, G N; Belafsky, P C

2017-04-01

To validate the ovine model of profound oropharyngeal dysphagia and compare swallowing outcomes of laryngotracheal separation with those of total laryngectomy. Under real-time fluoroscopy, swallowing trials were conducted using the head and neck of two Dorper cross ewes and one human cadaver, secured in lateral fluoroscopic orientation. Barium trials were administered at baseline, pre- and post-laryngohyoid suspension, following laryngotracheal separation, and following laryngectomy in the ovine model. Mean pre-intervention Penetration Aspiration Scale and National Institutes of Health Swallow Safety Scale scores were 8 ± 0 and 6 ± 0 respectively in sheep and human cadavers, with 100 per cent intra- and inter-species reproducibility. These scores improved to 1 ± 0 and 2 ± 0 post-laryngohyoid suspension (p < 0.01). Aerodigestive tract residue was 18.6 ± 2.4 ml at baseline, 15.4 ± 3.8 ml after laryngotracheal separation and 3.0 ± 0.7 ml after total laryngectomy (p < 0.001). The ovine model displayed perfect intra- and inter- species reliability for the Penetration Aspiration Scale and Swallow Safety Scale. Less aerodigestive tract residue after narrow-field laryngectomy suggests that swallowing outcomes after total laryngectomy are superior to those after laryngotracheal separation.

Hillary Clinton sai kolmes osariigis valusalt lüüa / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

USA presidendi eelvalimistel võitis Barack Obama oma pearivaali Hillary Clintonit nii Louisianas, Nebraskas kui Washingtonis ja sisuliselt viigistas üleriigilise parteidelegaatide arvestuse. Vt. samas: Huckabee ei anna ikka veel alla

78 FR 54735 - National Alcohol and Drug Addiction Recovery Month, 2013

Science.gov (United States)

2013-09-06

... on Pathways to Wellness'' encourages all Americans to walk alongside family, friends, and neighbors... moving along the life-saving path to recovery. NOW, THEREFORE, I, BARACK OBAMA, President of the United...

Recurrent Vestibular Migraine Vertigo Attacks Associated With the Development of Profound Bilateral Vestibulopathy: A Case Series.

Science.gov (United States)

Wester, Jacob L; Ishiyama, Akira; Ishiyama, Gail

2017-09-01

Bilateral vestibulopathy (BVP) is a debilitating condition characterized by gait ataxia, oscillopsia, and imbalance. Case series of patients with migraine-linked vertigo spells and profound BVP. PATIENT 1:: A 69-year-old man presented with a history of recurrent severe vertigo spells lasting up to 3 days in duration associated with prostrating migraine headaches starting at age 60. His symptoms were misdiagnosed as an anxiety syndrome. At age 68, electronystagmography (ENG) revealed bilaterally absent caloric responses and complete BVP. His hearing was normal. PATIENT 2:: A 51-year-old man presented with a history of "earthquake-like" vertigo, sharp head pain, and phonophobia. These episodes occurred a handful of times over a 7-year period. Previous ENG testing at age 43 was normal. However, his ENG at age 48 revealed complete BVP. He was started on acetazolamide and noted improved balance, although subsequent ENG was unchanged. PATIENT 3:: A 49-year-old woman presented with a history of recurrent migraines with visual aura associated with vertigo lasting 1 hour. ENG at age 50 revealed complete BVP. Subjectively, she noted improved balance with acetazolamide and subsequent ENG demonstrated mild improvement. PATIENT 4:: A 43-year-old man presented with a 5-year history of optical migraines and recurrent vertigo spells, lasting 30 seconds, which was misdiagnosed as positional vertigo. He additionally had a 10-year history of oscillopsia. ENG at age 61 revealed complete BVP. In these cases, vestibular migraine was linked to recurrent vertigo spells that eventually led to complete bilateral vestibulopathy.

Influenza or not influenza: Analysis of a case of high fever that happened 2000 years ago in Biblical time

Directory of Open Access Journals (Sweden)

Leung Ting F

2010-07-01

Full Text Available Abstract The Bible describes the case of a woman with high fever cured by our Lord Jesus Christ. Based on the information provided by the gospels of Mark, Matthew and Luke, the diagnosis and the possible etiology of the febrile illness is discussed. Infectious diseases continue to be a threat to humanity, and influenza has been with us since the dawn of human history. If the postulation is indeed correct, the woman with fever in the Bible is among one of the very early description of human influenza disease. Infectious diseases continue to be a threat to humanity, and influenza has been with us since the dawn of human history. We analysed a case of high fever that happened 2000 years ago in Biblical time and discussed possible etiologies.

The transformation from custodial to recovery-oriented care: a paradigm shift that needed to happen.

Science.gov (United States)

McKenna, Brian; Furness, Trentham; Dhital, Deepa; Park, Malcolm; Connally, Fiona

2014-01-01

As custodial mental health services are beginning to adopt a recovery-oriented model of care, it is imperative that successes in the transformation to recovery are captured. The aim of this illustrative case study was to describe the organizational procedure that enabled the systematic transformation of a custodial mental health service to a service with a self-professed recovery orientation as its model of service delivery. One-to-one interviews with key stakeholders and a document analysis were completed to thoroughly describe the transformation of the service. Four major themes arose from the data: (a) "We had this whole paradigm shift that needed to happen;" (b) "Think recovery," the development of a manualized guide; (c) "Stepping out my recovery;" adaptation of the service guide to the secure care context; and (d) developing the culture. The "developing the culture" major theme was subcategorized to consist of (a) the right people, (b) education, (c) reflective learning, and (d) leadership. The themes provided insights to assist mental health nurses to understand the processes involved in systems transformation. However, the major successes of the service, although only recently evaluated, commenced over a decade ago and yet continue to evolve.

Obama ja terroristid / Gwynne Dyer

Index Scriptorium Estoniae

Dyer, Gwynne

2009-01-01

Barack Obama USA presidendiks saamise järel on autori arvates oluliselt suurenenud oht, et terroristid võivad peagi ette võtta ulatusliku rünnaku Ameerika vastu, tekitamaks hirmutunnet USA avalikkuses

McCainiga hakkab rinda pistma Obama / Hendrik Vosman

Index Scriptorium Estoniae

Vosman, Hendrik

2008-01-01

USA demokraatide presidendikandidaat Hillary Clinton ei söandanud oma allajäämist Barack Obamale tunnistada. Lisa: Obama ja McCaini seisukohad. Vt. samas: Hillary Clinton võib saada asepresidendi kandidaadiks

Tugevad naised on tagasi / Naomi Wolf ; tõlk. Liisa Past

Index Scriptorium Estoniae

Wolf, Naomi

2008-01-01

Autor arutleb, miks valis Barack Obama riigisekretäriks Hillary Clintoni. Autor nimetab H. Clintoni üheks vaieldamatuks saavutuseks tema maailmas tehtud rännakuid, kus ta on keskendunud naistele olulistele teemadele

78 FR 33955 - Great Outdoors Month, 2013

Science.gov (United States)

2013-06-06

... come. NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, by virtue of the... Michelle Obama's Let's Move Outside! initiative encourages families to get out and enjoy our beautiful...

3 CFR - Biofuels and Rural Economic Development

Science.gov (United States)

2010-01-01

... biofuels promise to play a key role by providing the Nation with homegrown sustainable energy options and... publish this memorandum in the Federal Register.BARACK OBAMATHE WHITE HOUSE, Washington, May 5, 2009. ...

BP erioperatsioon naftalekke peatamiseks nurjus / Jürgen Tamme

Index Scriptorium Estoniae

Tamme, Jürgen

2010-01-01

Naftakompanii BP katse peatada Mehhiko lahe naftaleke ebaõnnestus, nüüd püütakse reostust peatada uue toru paigaldamise abil. USA president Barack Obama avaldas taas rahulolematust naftakompaniiga. Kaart

Obama alustab külaskäiku Venemaale keerulisel ajal / Liisi Poll

Index Scriptorium Estoniae

Poll, Liisi, 1980-

2009-01-01

USA president Barack Obama alustab 6. juulil oma Moskva visiiti, mille käigus on tal kavas lisaks Kremli juhtidele kohtuda ka opositioonitegelaste ning Nõukogude Liidu viimase juhi Mihhali Gorbatšoviga

Clinton pingutab juutide häälte eest / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

Hillary Clinton teatas, et oleks valmis totaalselt hävitama Iraani, kui see ründaks Iisraeli tuumarelvaga. Juutide lobigrupid pole rahul Barack Obamaga. USA juutidest toetab H. Clintonit 48%, B. Obamat 43%

USA politoloogid : Obama võit oleks ka Eesti oma / Laura Vetik

Index Scriptorium Estoniae

Vetik, Laura

2008-01-01

USA politoloogide sõnul oleks pingestunud Venemaa ja USA suhete taustal Eestile kasulikum, kui 56. USA presidendivalimised võidaks demokraat Barack Obama. Erinevate politoloogide hinnanguid. Vt. samas: Obama ja McCain loovad kabinette

Vanadium research recharged

International Nuclear Information System (INIS)

Luntz, Stephen

2011-01-01

US President Barack Obama has described Maria Skyllas-Kazacos’ research as “one of the coolest things I’ve ever said out loud”. Vanadium redox batteries could be electricity’s ultimate storage mechanism.

Kohtumine, mida Kreml igatseb / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2009-01-01

Eelseisvast USA presidendi Barack Obama ja Venemaa presidendi Dmitri Medvedevi kohtumisest Londonis G20 tippkohtumise eel, kus tõenäoliselt arutatakse võimalusi kahe suurriigi omavaheliste suhete parandamiseks ning majanduskriisi ületamiseks

Sõltumatud kodanikud otsustavad superriigi juhi saatuse / Christopher Kukk ; interv. Priit Pullerits

Index Scriptorium Estoniae

Kukk, Christopher

2008-01-01

Eesti päritolu Lääne-Connecticuti politoloogiaprofessor vastab küsimustele, mis puudutavad USA presidendivalimisi ja presidendikandidaatide Barack Obama ja John McCaini võimalusi. Vt. samas: Kes on Christopher Kukk?

USA valik : kas uus peatükk või retro? / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2008-01-01

USA presidendikandidaatide demokraat Barack Obama ja vabariiklase John McCaini debattidel pakutud erinevatest kurssidest. President George W. Bushi kriitikast tõenäolise demokraatide kandidaadi B. Obama seisukohtade suhtes. Lisa: Välispoliitilised seisukohad

Skandaal USAs : Obamat kujutati islamiterroristina / Aadu Hiietamm

Index Scriptorium Estoniae

Hiietamm, Aadu, 1954-

2008-01-01

The New Yorkeri esiküljel ilmus karikatuur, kus USA demokraatide presidendikandidaati Barack Obamat ja tema abikaasat Michelle'i kujutati islamiterroristidena, karikaturisti väitel joonistas ta selle Obama laimajate naeruvääristamiseks

Déjà vu: supermän draakoni hammaste vahel / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2009-01-01

Autor analüüsib USA prsidendi Barack Obama visiiti Hiinasse ning kohtumist presidendi Hu Jintaoga, mis sarnanes suuresti president John F. Kennedy esimese kohtumisega NSV Liidu liidri Nikita Hruštšoviga

Obama suunab kahuritule teadmata kadunud Osamale / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2009-01-01

Autori sõnul on USA tähelepanu hajumine võimaldanud al-Qaidal peituda ja neid varjaval Talibanil uuesti tugevneda. Esimene muutus, mille Barack Obama USA presidendina tegi, oli katse islamimaailma terroristidest eemale meelitada

Development of a Bone-Conducted Ultrasonic Hearing Aid for the Profoundly Deaf: Evaluation of Sound Quality Using a Semantic Differential Method

Science.gov (United States)

Nakagawa, Seiji; Fujiyuki, Chika; Kagomiya, Takayuki

2013-07-01

Bone-conducted ultrasound (BCU) is perceived even by the profoundly sensorineural deaf. A novel hearing aid using the perception of amplitude-modulated BCU (BCU hearing aid: BCUHA) has been developed. However, there is room for improvement particularly in terms of sound quality. BCU speech is accompanied by a strong high-pitched tone and contain some distortion. In this study, the sound quality of BCU speech with several types of amplitude modulation [double-sideband with transmitted carrier (DSB-TC), double-sideband with suppressed carrier (DSB-SC), and transposed modulations] and air-conducted (AC) speech was quantitatively evaluated using semantic differential and factor analysis. The results showed that all the types of BCU speech had higher metallic and lower esthetic factor scores than AC speech. On the other hand, transposed speech was closer than the other types of BCU speech to AC speech generally; the transposed speech showed a higher powerfulness factor score than the other types of BCU speech and a higher esthetic factor score than DSB-SC speech. These results provide useful information for further development of the BCUHA.

Segurança nacional e liberdades civis nos Estados Unidos: Obama e a opção pela segurança

Directory of Open Access Journals (Sweden)

Cláudio Júnior Damin

2013-10-01

Full Text Available O artigo analisa, à luz da experiência histórica dos EUA, as recentes denúncias de vigilância do Estado em relação aos indivíduos no governo de Barack Obama. Aborda-se a tensão entre segurança nacional e liberdades civis e como o democrata faz uma opção pela segurança, repetindo o padrão de presidentes anteriores.   The article examines, in the light of the historical experience of the U.S., recent reportsof state surveillance in relation to individuals in the government of Barack Obama. Addresses the tension between national security and civil liberties and how the Democrat did an option for safety, repeating the pattern of previous presidents.

78 FR 28461 - Military Spouse Appreciation Day, 2013

Science.gov (United States)

2013-05-14

... Forces initiative, we have partnered with the private sector to expand hiring for military spouses and..., let us pledge once more to serve them as well as they serve us. NOW, THEREFORE, I, BARACK OBAMA...

Obama jääb eestlastele võõraks / Jaanus Betlem

Index Scriptorium Estoniae

Betlem, Jaanus, 1961-

2010-01-01

Barack Obama näol on enamiku eestlaste jaoks tegemist järjekordse meediastaariga. Ta on nagu filminäitleja, kelle naeratus ehib seltskonnaajakirjade kaasi, kuid tegelik elu jääb lugejate eest varjatuks

Urban Geocaching: what Happened in Lisbon during the Last Decade?

Science.gov (United States)

Nogueira Mendes, R.; Rodrigues, T.; Rodrigues, A. M.

2013-05-01

Created in 2000 in the United States of America, Geocaching has become a major phenomenon all around the world, counting actually with millions of Geocaches (or caches) that work as a recreational motivation for millions of users, called Geocachers. During the last 30 days over 5,000,000 new logs have been submitted worldwide, disseminating individual experiences, motivations, emotions and photos through the official Geocaching website (www.geocaching.com), and several official or informal national web forums. The activity itself can be compared with modern treasure hunting that uses handheld GPS, Smartphones or Tablets, WEB 2.0, wiki features and technologies to keep Geocachers engaged with their activity, in a strong social-network. All these characteristics make Geocaching an activity with a strong geographic component that deals closely with the surrounding environment where each cache has been hidden. From previous work, significance correlation has been found regarding hides and natural/rural environments, but metropolitan and urban areas like Lisbon municipality (that holds 3.23% of the total 27534 Portuguese caches), still registers the higher density of Geocaches, and logs numbers. Lacking "natural/rural" environment, Geocaching in cities tend to happen in symbolic areas, like public parks and places, sightseeing spots and historical neighborhoods. The present study looks to Geocaching within the city of Lisbon, in order to understand how it works, and if this activity reflects the city itself, promoting its image and cultural heritage. From a freely available dataset that includes all Geocaches that have been placed in Lisbon since February 2001, spatial analysis has been conducted, showing the informal preferences of this activity. Results show a non-random distribution of caches within the study area, similar to the land use distribution. Preferable locations tend to be in iconic places of the city, usually close to the Tagus River, that concentrates 25

Postural control in children with typical development and children with profound hearing loss

Directory of Open Access Journals (Sweden)

Monteiro de Sousa AM

2012-05-01

Full Text Available Aneliza Maria Monteiro de Sousa,1 Jônatas de França Barros,2 Brígido Martins de Sousa Neto31Faculty of Health Sciences, University of Brasilia, Brasilia, Federal District, Brazil; 2Department of Physical Education at the Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; 3University Center UNIEURO, Brasilia, Federal District, BrazilPurpose: To describe the behavior of the postural control in children with profound sensorineural hearing loss and compare the results of experimental tests with hearing children aged 7 to 10 years.Patients and methods: This is a cross-sectional study where 100 children were divided into experimental and control groups. We used a force platform, AccuSway Plus, where the tests were conducted under the experimental conditions: open base, eyes open (OBEO; open base, eyes closed (OBEC; closed base, eyes open (CBEO; closed base, eyes closed (CBEC. The body sway velocity (V of the center of pressure, the displacement in the anteroposterior direction (COPap and mediolateral (COPml of the center of pressure were the parameters to evaluate the postural control. For statistical analysis we used the nonparametric Mann–Whitney U test, with a significance level of 5%.Results: In comparisons of variables between the groups, the experimental group outperformed by at least 75% of the control group values. In terms of global trends, the experimental group shows higher values of body oscillations in all experimental conditions and variables evaluated. Children with hearing loss had poorer balance performance compared to the group of hearing. The inferential analysis revealed a statistically significant difference in the balance between deaf and hearing children in the OBEC experimental condition in relation to the COPml parameter (P = 0.04. There were no statistically significant differences in comparisons between the sexes when the groups were analyzed separately. The prevalence of unknown etiology

Transportation challenges for the new administration : perspectives of past DOT secretaries

Science.gov (United States)

2009-01-01

On January 29, 2009, the RAND Corporation hosted a panel discussion with three former U.S. secretaries of transportation. This wide-ranging discussion, held the week after President : Barack Obamas inauguration and during the congressional debate ...

Christianity, sport and disability: a case study of the role of long-distance running in the life of a father and his son who is congenitally blind and has profound intellectual disabilities

OpenAIRE

Watson, Nick J.; Parker, Andrew

2012-01-01

The aim of this qualitative case study was to explore the role of sport (longdistance running) in the lives of a father and his son who is congenitally blind and has profound intellectual disabilities. Drawing on the works of Jean Vanier, Stanley Hauerwas, Henri Nouwen and John Hull, the major themes explored are relational and religious trust, suffering, sacrificial love, embodiment and blindness. A series of one-to-one semi-structured interviews were conducted with the father (and mother) c...

Therapists' experiences and perceptions of teamwork in neurological rehabilitation: critical happenings in effective and ineffective teamwork.

Science.gov (United States)

Suddick, Kitty M; De Souza, Lorraine H

2007-12-01

This paper reports the second part of an exploratory study into occupational therapists' and physiotherapists' perceptions and experiences of teamwork in neurological rehabilitation: the factors that were thought to influence effective and ineffective teamwork, and the meaning behind effective and ineffective teamwork in neurological rehabilitation. The study was undertaken through semi-structured interviews of 10 therapists from three different neurological rehabilitation teams based in the United Kingdom, and used the critical incident technique. Through analysis of the data, several main themes emerged regarding the perceived critical happenings in effective and ineffective teamwork. These were: team events and characteristics, team members' characteristics, shared and collaborative working practices, communication, specific organizational structures, environmental, external, and patient and family-related factors. Effective and ineffective team-work was perceived to impact on a number of levels: having implications for the team, the patient, individual team members, and the neurological rehabilitation service. The study supported the perceived value of team work within neurological rehabilitation. It also indicated the extensive and variable factors that may influence the team-working process as well as the complex and diverse nature of the process.

George Soros : kriis on arvatust palju hullem / George Soros ; interv. Külli-Riin Tigasson

Index Scriptorium Estoniae

Soros, George, 1930-

2008-01-01

USA miljardär ja filantroop vastab küsimustele, mis puudutavad tema toetust Barack Obamale, praegust finantskriisi ja selle kestust, Euroopa käitumist Venemaaga ja demokraatia võimalikkust Venemaal, demokraatia arengut Kesk- ja Ida-Euroopas

Ilves kohtus Obamaga

Index Scriptorium Estoniae

2010-01-01

President Toomas Hendrik Ilves kohtus 8. aprillil 2010 Prahas USA presidendi Barack Obamaga. USA riigipea arutas Prahas julgeolekuküsimusi 11 Kesk- ja Ida-Euroopa riigi valitsusjuhi või riigipeaga. Töövisiit Prahasse 08.04.2010

Kes julgeb 2012. aastal Obamale vastu astuda? / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2011-01-01

Kui USA demokraatlikus parteis ei ole Barack Obamale ühtki rivaali, siis vabariiklaste parteis on mitmeid, kes tahaksid presidendiks kandideerida. Esimesele avalikule debatile Iowas kutsuti kaheksa kandidaati, 28,6% Iowa vabariiklastest eelistas nn. teepartei liidrit Michele Bachmanni

Üks täht on langenud: aasta Obama võidust / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2009-01-01

Autor analüüsib USA presidendi Barack Obama populaarsuse langust ning märgib, et ootused, millega kuulati B. Obama võidukõnet, on asendunud rahutuks muutunud suhtumisega tema ametis hakkama saamisesse. Lisa: 6 murtud lubadust

Strategii de reducere a deficitelor şi datoriei publice a Statelor Unite ale Americii adoptate de Administraţia Obama

Directory of Open Access Journals (Sweden)

Rodica Velciu

2011-10-01

Full Text Available At the beginning of the second decade of the 21st century, the sovereign debts of one of the largest economies of the world were “blown up” because of the ageing population and the costs determined by the financial crisis. According to an analysis by Standard & Poor’s rating agency, if governments maintain current fiscal policies, for 49 states representing 2/3 of the world population, the average debt as percentage of GDP will reach 245% by 2050. "The pressure of increasing expenses will determine profound changes in the economical perspectives of these countries. The erosion will start in 2015, when the quota of many states with high rating will start being under pressure", declare the Agency’s analysis. In mid April 2011, Barack Obama announced the elaboration of an ambitious plan for the reduction of the federal budget deficit, in total amount of USD 4,000 billion, over a period of 12 years. Democrat and Republican leaders of the Congress reached an agreement in respect to the raise of the debt limits, after months of intense closed-doors negotiations and only two days before the due date set by the Ministry of Finance. In order to avoid payment default, democrats and republicans reached an agreement to increase the leveraging to USD 14,300 billion, by USD 2,100 billion. Moreover, this agreement establishes a reduction of governmental expenses for the next 10 years with up to USD 3,000 billion and enough loans in order to avoid another increase in the leveraging limits in 2013. In turn, FED announced they will maintain stimulating policies for another two years, although in June the economic stimulation program should have ended. The monetary policy interest rate is at the lowest level in the history of the Central Bank, between 0% and 0.25% since 2008. At the beginning of September, President Barack Obama presented a new plan of economic revival and labor market support for a period of six years, rounded at USD 447 billion, in the

What parents find important in the support of a child with profound intellectual and multiple disabilities.

Science.gov (United States)

Jansen, S L G; van der Putten, A A J; Vlaskamp, C

2013-05-01

The importance of a partnership between parents and professionals in the support of children with disabilities is widely acknowledged and is one of the key elements of 'family-centred care'. To what extent family-centred principles are also applied to the support of persons with profound intellectual and multiple disabilities (PIMD) is not yet known. The purpose of this exploratory study was to examine what parents with a child with PIMD find important in the support of their child. In addition, we examined which child or parent characteristics influence these parental opinions. In total, 100 parents completed an adapted version of the Measure of Processes of Care. Mean unweighted and weighted scale scores were computed. Non-parametric tests were used to examine differences in ratings due to child (gender, age, type and number of additional disabilities, type of services used and duration of service use) and parent characteristics (gender, involvement with support and educational level). Parents rated situations related to 'Respectful and Supportive Care' and 'Enabling and Partnership' with averages of 7.07 and 6.87 respectively on a scale from 1 to 10. They were generally satisfied with the services provided, expressed in a mean score of 6.88 overall. The age of the child significantly affected the scores for 'Providing Specific Information about the Child'. Parents of children in the '6-12 years' age group gave significantly higher scores on this scale than did parents of children in the '≥17 years' age group (U = 288, r = -0.34). This study shows that parents with children with PIMD find family-centred principles in the professional support of their children important. Although the majority of parents are satisfied with the support provided for their children, a substantial minority of the parents indicated that they did not receive the support they find important. © 2012 Blackwell Publishing Ltd.

What Happens to Bio-degradables in the Ocean? Due to the increasing amount of plastic that ends up in the ocean there is much alarm about it killing sea life from ingestion and changing chemical properties of the ocean. But what really happens t these products in the ocean, and how do they affect the ocean.

Science.gov (United States)

Lavoie, A.

2016-12-01

What Happens to Bio-degradables in the Ocean? Due to the increasing amount of plastic that ends up in the ocean there is much alarm about it killing sea life from entanglement and ingestion and changing chemical properties of the ocean. Our society is trying to take action by purchasing and using materials that claim to be biodegradable. But how long do these materials take to degrade in ocean water and do they actually change the water composition? Answering these questions will determine if one should invest in these materials as an alternative to plastic.

Developing and Implementing School for Highly Gifted, Exceptionally Gifted, and Profoundly Gifted Students: An Interview with Lynette Breedlove

Directory of Open Access Journals (Sweden)

Engin KARADUMAN

2013-12-01

Full Text Available According to research, while moderately gifted students can often fit in the regular classrooms with differentiated instructions, pull-out programs, or acceleration options, highly gifted students do better when they are grouped with other intellectually-advanced peers in accordance with their strengths, interests, and background knowledge of a topic. Each of these students requires special attention and management strategies to develop better cognitive, social, emotional, and physical skills. Thanks to the grouping strategy, highly gifted students can study concepts at the appropriate pace, depth, and complexity so that these students feel valued and normal (Neville, 2007; Rogers, 2007. In order to fully meet these students’ needs, creating a school for highly, exceptionally, and profoundly gifted students would be a more beneficial plan compared to requiring them to stay within the regular classroom, accelerating, or grade skipping. Rogers (2002 pointed out that these students showed more academic growth by studying with other intellectual peers in separate classrooms. According to VanTassel-Baska (2006, identification, curriculum, program design, staff development, parental involvement assessment, and evaluation areas were essential for gifted program development. In accordance with the program development guidelines noted above, in this presentation, the process of developing and implementing a program for highly gifted students in Science, Math, Reading, and Social Studies will be provided based on an interview with Lynette Breedlove, Ph.D. who is the director of Advanced Academic Studies & Secondary Counseling at Spring Branch Independent School District in Houston, TX.

The Challenge in Europe / Toomas Hendrik Ilves

Index Scriptorium Estoniae

Ilves, Toomas Hendrik, 1953-

2008-01-01

Eesti presidendi nõuanded USA presidendiks valitud Barack Obamale. Eesti riigipea kutsub Ameerika Ühendriike üles kaitsma liberaalse demokraatia väärtusi ning rõhutab USA ja Euroopa koostöö tähtsust Venemaa ohjeldamisel

Africa Development - Vol 38, No 1&2 (2013)

African Journals Online (AJOL)

US Foreign Policy under President Barack Obama and the Promotion of Multilateralism and the Rule of Law · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. AMB Mangu, 171-190 ...

Pakistan tõestas taas nõrkust terroristide ohjeldamisel / Oliver Tiks

Index Scriptorium Estoniae

Tiks, Oliver

2009-01-01

Pakistanis toimus sisside verine terrorirünnak politseiakadeemia vastu, mis analüütikute hinnagul oli sõnumiks USA presidendile Barack Obamale, kes on seadnud Pakistani kesksele kohale võitluseks AL-Qaeda terroristidega. Kaart: Pakistani rünnak

Communication training for centre-based carers of children with severe or profound disabilities in the Western Cape, South Africa

Directory of Open Access Journals (Sweden)

Martha Geiger

2012-09-01

Full Text Available The purpose of this paper is to provide a preliminary, qualitative review of an approach to training centre-based carers in supporting basic communication development and providing communication opportunities for the children with severe and profound disabilities in their care. In South Africa, these children are often the most neglected in terms of planning and providing appropriate interventions. For those with severe communication disabilities, an additional lack is in the area of the basic human right to meaningful interactions and communication. Sustainable strategies to provide opportunities for basic communication development of these children are urgently sought. Several effective international and local parent training programmes have been developed, but the urgent need remains to train centre-based carers who are taking care of groups of diversely disabled children in severely under-resourced settings. Non-profit organisations (NPOs have been exploring practical centre-based approaches to skills sharing in physical rehabilitation, activities for daily living, feeding and support for basic communication development. As a freelance speech therapist contracted by four NPOs to implement hands-on training in basic communication for centre-based carers of non-verbal children, the author describes a training approach that evolved over three years, in collaboration with the carers and centre managements. Implications for training (for speech therapists and for community-based rehabilitation workers and for further research are identified.

Dr. Francis Collins Is New NIH Director

Science.gov (United States)

... Ph.D., a physician and geneticist, is the new Director of the National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services. President Barack Obama nominated Dr. Collins, who served as Director of ...

Karzai nõuab USA-lt võitu, ähvardades muidu rahu teha / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2008-01-01

Afganistani president Hamid Karzai nõuab USA-lt ajakava selle kohta, millal NATO kavatseb Talibani üle võidu saavutada. Afganistanis visiidil viibinud USA president George W. Bush avaldas toetust Barack Obama kavale keskenduda veelgi enam Afganistanis sõdimisele

3 CFR 8343 - Proclamation 8343 of January 20, 2009. National Day of Renewal and Reconciliation, 2009

Science.gov (United States)

2010-01-01

... land, will yet swell the chorus of the Union, when again touched, as surely they will be, by the better angels of our nature.” NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America, by the...

Obama kriisitiimi juhib tugev kolmik / Sirje Rank

Index Scriptorium Estoniae

Rank, Sirje, 1966-

2008-01-01

USA presidendiks valitud Barack Obama kuulutab ametlikult välja oma meeskonna liikmed. Tulevane rahandusminister Timothy Geithner ning Valge Maja koordinatsiooni nõukogu tulevane juht Lawrence Summers seisavad vastamisi finantskriisi ületamise ning finantssüsteemi stabiliseerimise ülesandega

Obama sai rahupreemia liiga vara / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2009-01-01

Norra Nobeli komitee meelest väärib USA president Barack Obama rahupreemiat selle eest, et ta on andnud maailmale "parema tuleviku lootuse" oma tööga rahu nimel ja üleskutsetega vähendada tuumarelvastust kogu maailmas

Ex-diplomacy captain slags off the government / Povilas Gylys ; interviewed by Linas Jegelevicius

Index Scriptorium Estoniae

Gylys, Povilas

2011-01-01

Leedu endine välisminister ei taha poliitikasse tagasi tulla, räägib Leedu majandusest ja ei ole rahul sellega, et USA presidendi Barack Obama käest kutse saanud Leedu riigipea Dalia Grybauskaite ei sõitnud Praha kohtumisele

Pikk mees ja lühike mees kohtuvad Kremlis / Enn Soosaar

Index Scriptorium Estoniae

Soosaar, Enn, 1937-2010

2009-01-01

USA presidendi Barack Obama eelseisvast kohtumisest Venemaa presidendi Dmitri Medvedeviga. Juttu on ka 15. juunil 2009 Washingtonis toimunud USA presidendi B. Obama ja Eesti presidendi Toomas Hendrik Ilvese plaanivälisest kohtumisest, viidates artiklile: Summertime blues. The Economist, 18. juuni 2009

77 FR 8809 - United States Travel and Tourism Advisory Board; Teleconference Meeting

Science.gov (United States)

2012-02-15

... DEPARTMENT OF COMMERCE International Trade Administration United States Travel and Tourism... Commerce. ACTION: Notice of an open teleconference meeting. SUMMARY: The United States Travel and Tourism... National Travel and Tourism Strategy (Strategy). The Executive Order was issued by President Barack Obama...

В Нью-Йорке поминали жертв 11 сентября / Неэме Рауд

Index Scriptorium Estoniae

Рауд, Неэме, 1969-

2011-01-01

USA president Barack Obama ja välisminister Hillary Clinton rõhutasid 11. septembri terrorirünnaku aastapäeval, et Ameerika Ühendriigid ei tohi oma valvsust kaotada, sest terrorioht ei kao kuhugi. New Yorgis toimunud mälestustseremooniast

Obama: me keeldume elamast hirmus / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2011-01-01

USA president Barack Obama ja välisminister Hillary Clinton rõhutasid 11. septembri terrorirünnaku aastapäeval, et Ameerika Ühendriigid ei tohi oma valvsust kaotada, sest terrorioht ei kao kuhugi. New Yorgis toimunud mälestustseremooniast

Obamad kui Kennedyte taastulek 21. sajandil / Barbi Pilvre

Index Scriptorium Estoniae

Pilvre, Barbi, 1963-

2008-01-01

USA demokraatide presidendikandidaadile Barack Obamale ja tema abikaasale Michelle'ile on loodud kennedylik imago, selle imago taga on demokraat Ted Sorensen, kes aitas kunagi võimule tulla John F. Kennedyl. Ka Kennedyd ise on üles astunud B. Obama toetajana

Results of President Obama's Race to the Top

Science.gov (United States)

Howell, William G.

2015-01-01

Caught between extraordinary public expectations and relatively modest constitutional authority, U.S. presidents historically have fashioned all sorts of mechanisms--executive orders, proclamations, memoranda--by which to move their objectives forward. William Howell asserts that under President Barack Obama's administration, presidential…

Advice for Trump

Science.gov (United States)

Gwynne, Peter

2017-05-01

Physicist John Holdren, who served as presidential science adviser and head of the Office of Science and Technology Policy during Barack Obama’s presidency, talks to Peter Gwynne about his expectations for the Trump administration’s approach to science and technology

End of Obamacare.

Science.gov (United States)

Price, Jacqueline

2016-12-07

I write this with the results of the recent US presidential election fresh in my mind. In January 2017, Republican candidate Donald Trump will stand next to outgoing President Barack Obama at the White House and will be inaugurated president.

What happens after a request for euthanasia is refused? Qualitative interviews with patients, relatives and physicians.

Science.gov (United States)

Pasman, H Roeline W; Willems, Dick L; Onwuteaka-Philipsen, Bregje D

2013-09-01

Obtaining in-depth information from both patient and physician perspectives about what happens after a request for euthanasia or physician-assisted suicide (EAS) is refused. In-depth interviews with nine patients whose EAS request was refused and seven physicians of these patients, and with three relatives of patients who had died after a request was refused and four physicians of these patients. Interviews were conducted at least 6 months after the refusal. A wish to die remained in all patients after refusal, although it sometimes diminished. In most cases patient and physician stopped discussing this wish, and none of the physicians had discussed plans for the future with the patient or evaluated the patient's situation after their refusal. Physicians were aware of patients' continued wish to die. Patients who are refused EAS may subsequently be silent about a wish to die without abandoning it. Open communication about wishes to die is important, even outside the context of EAS, because if people feel unable to talk about them, their quality of life may be further diminished. Follow up appointments after refusal could give patients the opportunity to discuss their feelings and physicians to support them. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Speech and language therapists' approaches to communication intervention with children and adults with profound and multiple learning disability.

Science.gov (United States)

Goldbart, Juliet; Chadwick, Darren; Buell, Susan

2014-11-01

People with profound intellectual and multiple disabilities (PMLD) have communication impairments as one defining characteristic. To explore speech and language therapists' (SLTs) decision making in communication interventions for people with PMLD, in terms of the intervention approaches used, the factors informing the decisions to use specific interventions and the extent to which the rationales underpinning these decisions related to the components of evidence based practice (EBP), namely empirical evidence, clinical experience and client/carer views and values. A questionnaire on communication assessment and intervention for people with PMLD was sent to SLTs in the UK to elicit information on: the communication intervention approaches they used; their rationales for their intervention choices; their use of published evidence to inform decision making. Intensive interaction and objects of reference were the communication interventions most often used with people with PMLD, with some differences between children and adults evident. Rationales provided conformed somewhat to the EBP framework though extension of the existing framework and addition of practical and organizational considerations led to a revised typology of rationale for decision making. Rationales most frequently related to the empowerment, development and behavioural preferences of the person with PMLD. Empirical research evidence was seldom mentioned by SLTs as informing intervention decision making leading to very diverse practice. There is a need for further research on the effectiveness of commonly used but under-evaluated interventions. There is also a need to alert SLTs to the evidence base supporting other approaches, particularly switch-based, cause and effect approaches. © 2014 Royal College of Speech and Language Therapists.

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects.

Science.gov (United States)

Kechagias, S; Ernersson, A; Dahlqvist, O; Lundberg, P; Lindström, T; Nystrom, F H

2008-05-01

To study the effect of fast-food-based hyper-alimentation on liver enzymes and hepatic triglyceride content (HTGC). Prospective interventional study with parallel control group. University Hospital of Linköping, Sweden. 12 healthy men and six healthy women with a mean (SD) age of 26 (6.6) years and a matched control group. Subjects in the intervention group aimed for a body weight increase of 5-15% by eating at least two fast-food-based meals a day with the goal to double the regular caloric intake in combination with adoption of a sedentary lifestyle for 4 weeks. Weekly changes of serum aminotransferases and HTGC measured by proton nuclear magnetic resonance spectroscopy at baseline and after the intervention. Subjects in the intervention group increased from 67.6 (9.1) kg to 74.0 (11) kg in weight (p19 U/l, men >30 U/l) during the intervention. Sugar (mono- and disaccharides) intake during week 3 correlated with the maximal ALT/baseline ALT ratio (r = 0.62, p = 0.006). HTGC increased from 1.1 (1.9)% to 2.8 (4.8)%, although this was not related to the increase in ALT levels. ALT levels were unchanged in controls. Hyper-alimentation per se can induce profound ALT elevations in less than 4 weeks. Our study clearly shows that in the evaluation of subjects with elevated ALT the medical history should include not only questions about alcohol intake but also explore whether recent excessive food intake has occurred.

Amide-linked Ethanolamine Conjugate of Gemfibrozil as a Profound HDL Enhancer: Design, Synthesis, Pharmacological Screening and Docking Study.

Science.gov (United States)

Rai, Himanshu; Dhaneshwar, Suneela S

2015-01-01

Elevated concentration of any or all types of lipids in the plasma including hypertriglyceridemia and hypercholesterolemia leads to atherosclerotic cardiovascular disease. Effective medication needs multiple drug therapy as recommended cholesterol and triglyceride levels are difficult to achieve by monotherapy and frequently require the use of more than one lipid-lowering medication. Gemfibrozil lowers plasma triglyceride-rich lipoproteins mainly VLDL and increases HDL. It is associated with short plasma half-life (1.5h) and GIT distress on long term use. In a study it was found that ethanolamine decreases serum cholesterol, especially VLDL cholesterol and LDL cholesterol in rats fed an HF/HC diet. In the present work, we thought of exploring the effect of co-drug of gemfibrozil with ethanolamine (GE-I) as a potential combination therapy for the management of mixed hyperlipidemia. Synthesis of GE-I was effected by CDI coupling. Structure was confirmed spectrally. Interestingly kinetic studies revealed that GE-I resisted chemical and enzymatic hydrolysis. In tritoninduced hyperlipidemia, significant lowering of serum lipid levels was observed. The hallmark of GEI was its profound effect on HDL level which was raised above the normal level by 15%. Docking study also supported modulatory effect of GE-I (docking score -7.012) on PPAR-α which was comparable to docking score of gemfibrozil (-9.432). These preliminary observations prompt us to consider GE-I as a novel, serendipitous, hybrid anti-hyperlipidemic new chemical entity which needs be studied extensively to prove it as an HDL enhancing anti-hyperlipidemic agent.

Attitudes toward blacks in the Obama era changing distributions and impacts on job approval and electoral choice, 2008-2012

NARCIS (Netherlands)

Pasek, Josh; Stark, Tobias; Krosnick, Jon A.; Tompson, Trevor; Payne, B. Keith

2014-01-01

Much published research indicates that voting behavior in the 2008 presidential election and evaluations of Barack Obama were importantly influenced by anti-Black sentiment. Various psychological theories made opposing predictions as to whether exposure to the first Black president during his first

Fulltext PDF

Indian Academy of Sciences (India)

THOLASI

would be the first woman candidate, and Barack Obama, who would be the first person of ... giving women the right to vote in 1920, or the black civil rights movement of the 1960's. ... people of India, irrespective of race, gender, or religion.

From Frozen Ties to Strategic Engagement: U.S.-Iranian Relationship in 2030

Science.gov (United States)

2015-05-01

proverb .1 NEW ADMINISTRATIONS AND THE POTENTIAL FOR CHANGE When Barack Obama assumed the U.S. presidency in 2009, he emphasized engagement with...Tactics without strategy is the noise before defeat. Chinese proverb (apocryphally attributed to Sun Tzu).1 STEERING RELATIONSHIPS WITH KEY

What motivates a conspiracy theory? Birther beliefs, partisanship, liberal-conservative ideology, and anti-Black attitudes

NARCIS (Netherlands)

Pasek, Josh; Stark, Tobias H.|info:eu-repo/dai/nl/335996701; Krosnick, Jon A.; Tompson, Trevor

2015-01-01

Despite the release of his birth certificate, some Americans express continued skepticism over whether Barack Obama was born in the United States. This study examined two possible causes of birther beliefs: that Republicans and conservatives, whose ideological beliefs and policy preferences led to

Obama hirmutamistaktika võib mõjuda tagasilöögina / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2009-01-01

USA president Barack Obama kasutas majanduse päästeplaani läbisurumisel sõnu "kriis", "katastroof" ja "häving". Vaatlejate hinnangul võib sellisel taktikal olla ka tagasilöök - hirmunud inimesed ei hakka raha kulutama ja retsessioon pikeneb

Tra storia e mito. Politiche e usi politici di Abraham Lincoln

Directory of Open Access Journals (Sweden)

Marco Sioli

2010-03-01

Full Text Available

Barack Obama's election brought to the forefront one of the key figures of the nineteenth century, Abraham Lincoln, considered to be a founder of the nation by the new American President. Like Lincoln, Obama put the accent on unity and national goodwill. Like Lincoln, Obama nourished the roots that connected to the common man. The deep desire for change in American politics that Obama espouses also occurred during Lincoln's presidency.

This essay dwells on Lincoln's words that are impressive in many respects, especially in the way they are able to communicate the passion of political involvement, as well as are impressive the images which represent the Great Emancipator in the different period of American history. Words and images reinterpreted Lincoln's myth in a contemporary mood, showing the how Lincoln became a continuously changing icon, down to the current presidency of Barack Obama.

Tra storia e mito. Politiche e usi politici di Abraham Lincoln

Directory of Open Access Journals (Sweden)

Marco Sioli

2010-03-01

Full Text Available Barack Obama's election brought to the forefront one of the key figures of the nineteenth century, Abraham Lincoln, considered to be a founder of the nation by the new American President. Like Lincoln, Obama put the accent on unity and national goodwill. Like Lincoln, Obama nourished the roots that connected to the common man. The deep desire for change in American politics that Obama espouses also occurred during Lincoln's presidency. This essay dwells on Lincoln's words that are impressive in many respects, especially in the way they are able to communicate the passion of political involvement, as well as are impressive the images which represent the Great Emancipator in the different period of American history. Words and images reinterpreted Lincoln's myth in a contemporary mood, showing the how Lincoln became a continuously changing icon, down to the current presidency of Barack Obama.

Narrator-in-Chief

DEFF Research Database (Denmark)

Herron, Mark A.

. The use of narratives of and by presidents in the White House can be seen as an essential part of the ceremonial role of the presidency. This use of narratives in epideictic speech has increased with modern day interests in the domestic life of the president, and the use of visual mass media......The dissertation Narrator-in-Chief: The Narrative Rhetoric of Barack Obama seeks to show how the concept of “narrative” can be used in rhetorical criticism of presidential speeches, particularly when considering the speeches and the biographical text, Dreams from My Father (1995), of Barack Obama...... as a communication platform for the president. While this has been described as a negative development (Stuckey, 1991; Salmon, 2010) this dissertation argues that narrative rhetoric should not be seen only as a negative part of political rhetoric, but also as a possibly vital way to educate the audience on issues...

Is ENSO related to 2015 Easter Star Capsized on the Yangtze River of China?

Science.gov (United States)

Xie, P.

2015-12-01

Natural disasters have profound effects on community security and economic damage of China's Hubei province. In June 1st, 2015, a cruise ship, Easter Star, capsized on Yangtze River in Hubei province with 442 died. What reason gives rise to such strong convection causing ship sunk? Based on the wind disasters of Hubei province happened in 1963-2015, this study analyzes their features bytime-series regression, and correlates them to global El Niño/Southern Oscillation (ENSO) events. The compared results demonstrated that the wind disasters shown an increasing tendency. There are two peaks corresponding to the strongest ENSO peaks during the past 50 years; each peak lasts two-three years. The facts demonstrated an essential linear relation between the ENSO phenomena and wind disasters in Hubei province. 2015 Easter Star capsized happened at current El Niño event in 2014-2015. We also observed that the historical wind disasters appeared in seasonal variation. Over 90% events concentrated in spring and summer; very few events happened in autumn and winter. Moreover, the disasters depend on the geographic conditions. Most disasters concentrated in four zones, named as Xingshan-Baokang, Xuanen, Wufeng-Yichang, Jingzhou-Gongan, in which Xingshan and Changyang are the two most density of zones. Yangtze River provides an air flowing conduct for strong convective winds. It can be concluded that the strong convection causing 2015 Easter Star capsized is related to current global ENSO phenomenon.Keywords: ENSO, wind disaster, time-series regression analysis, Easter Star, Yangtze River, Hubei Province,

U. S. Central Asian policy under president Barack Obama

OpenAIRE

Laumulin, Murat

2010-01-01

There can be no doubt that during the eighteen months it has been in power, the Obama Administration has in due course defined the main vectors and priorities of U.S. foreign policy, determined the country's key geopolitical interests, drawn up and adopted a National Security Strategy, and compiled a Nuclear Policy Review. The following factors are having an impact on U.S. policy in the post-Soviet expanse, which includes Central Asia (CA): relations with Russia, the PRC, the Islamic Republic...

A sociologia pública em tempos de Barack Obama

Directory of Open Access Journals (Sweden)

Michael Burawoy

Full Text Available O presente artigo, baseado em discurso dirigido à Sociedade Japonesa de Sociologia, na Universidade de Tohoku, recoloca as formulações centrais da sociologia pública, identificando os quatro estilos do fazer sociológico. Isso é feito à luz do cenário aberto com a profunda crise por que passa o sistema capitalista mundial. Mesmo ciente das diferentes tradições nacionais e da desigualdade internacional, e apesar delas, acreditamos que, como sociólogos, compartilhamos uma ambição e uma missão comum, que seria o combate ao paradigma baseado no fundamentalismo do mercado, que atualmente demonstra gravíssimos sinais de crise e de exaustão. Nesse sentido, resulta como tarefa primordial que os sociólogos canalizem as reações à crise em direção à criação de uma sociedade civil mais fortalecida e democrática, e de uma esfera pública mais robusta e inclusiva.

Multimodal MR-imaging reveals large-scale structural and functional connectivity changes in profound early blindness

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Bauer, Corinna M.; Hirsch, Gabriella V.; Zajac, Lauren; Koo, Bang-Bon; Collignon, Olivier

2017-01-01

In the setting of profound ocular blindness, numerous lines of evidence demonstrate the existence of dramatic anatomical and functional changes within the brain. However, previous studies based on a variety of distinct measures have often provided inconsistent findings. To help reconcile this issue, we used a multimodal magnetic resonance (MR)-based imaging approach to provide complementary structural and functional information regarding this neuroplastic reorganization. This included gray matter structural morphometry, high angular resolution diffusion imaging (HARDI) of white matter connectivity and integrity, and resting state functional connectivity MRI (rsfcMRI) analysis. When comparing the brains of early blind individuals to sighted controls, we found evidence of co-occurring decreases in cortical volume and cortical thickness within visual processing areas of the occipital and temporal cortices respectively. Increases in cortical volume in the early blind were evident within regions of parietal cortex. Investigating white matter connections using HARDI revealed patterns of increased and decreased connectivity when comparing both groups. In the blind, increased white matter connectivity (indexed by increased fiber number) was predominantly left-lateralized, including between frontal and temporal areas implicated with language processing. Decreases in structural connectivity were evident involving frontal and somatosensory regions as well as between occipital and cingulate cortices. Differences in white matter integrity (as indexed by quantitative anisotropy, or QA) were also in general agreement with observed pattern changes in the number of white matter fibers. Analysis of resting state sequences showed evidence of both increased and decreased functional connectivity in the blind compared to sighted controls. Specifically, increased connectivity was evident between temporal and inferior frontal areas. Decreases in functional connectivity were observed

A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.

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Schoch, Kelly; Meng, Linyan; Szelinger, Szabolcs; Bearden, David R; Stray-Pedersen, Asbjorg; Busk, Oyvind L; Stong, Nicholas; Liston, Eriskay; Cohn, Ronald D; Scaglia, Fernando; Rosenfeld, Jill A; Tarpinian, Jennifer; Skraban, Cara M; Deardorff, Matthew A; Friedman, Jeremy N; Akdemir, Zeynep Coban; Walley, Nicole; Mikati, Mohamad A; Kranz, Peter G; Jasien, Joan; McConkie-Rosell, Allyn; McDonald, Marie; Wechsler, Stephanie Burns; Freemark, Michael; Kansagra, Sujay; Freedman, Sharon; Bali, Deeksha; Millan, Francisca; Bale, Sherri; Nelson, Stanley F; Lee, Hane; Dorrani, Naghmeh; Goldstein, David B; Xiao, Rui; Yang, Yaping; Posey, Jennifer E; Martinez-Agosto, Julian A; Lupski, James R; Wangler, Michael F; Shashi, Vandana

2017-02-02

Whole-exome sequencing (WES) has increasingly enabled new pathogenic gene variant identification for undiagnosed neurodevelopmental disorders and provided insights into both gene function and disease biology. Here, we describe seven children with a neurodevelopmental disorder characterized by microcephaly, profound developmental delays and/or intellectual disability, cataracts, severe epilepsy including infantile spasms, irritability, failure to thrive, and stereotypic hand movements. Brain imaging in these individuals reveals delay in myelination and cerebral atrophy. We observe an identical recurrent de novo heterozygous c.892C>T (p.Arg298Trp) variant in the nucleus accumbens associated 1 (NACC1) gene in seven affected individuals. One of the seven individuals is mosaic for this variant. NACC1 encodes a transcriptional repressor implicated in gene expression and has not previously been associated with germline disorders. The probability of finding the same missense NACC1 variant by chance in 7 out of 17,228 individuals who underwent WES for diagnoses of neurodevelopmental phenotypes is extremely small and achieves genome-wide significance (p = 1.25 × 10 -14 ). Selective constraint against missense variants in NACC1 makes this excess of an identical missense variant in all seven individuals more remarkable. Our findings are consistent with a germline recurrent mutational hotspot associated with an allele-specific neurodevelopmental phenotype in NACC1. Copyright © 2017 American Society of Human Genetics. All rights reserved.

The 2009 Nobel Prize in Chemistry: Thomas A. Steitz and the structure of the ribosome.

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Zhao, Peter

2011-06-01

Over the past 200 years, there have been countless groundbreaking discoveries in biology and medicine at Yale University. However, one particularly noteworthy discovery with profoundly important and broad consequences happened here in just the past two decades. In 2009, Thomas Steitz, the Sterling Professor of Molecular Biophysics & Biochemistry, was awarded the Nobel Prize in Chemistry for "studies of the structure and function of the ribosome," along with Venkatraman Ramakrishnan of the MRC Laboratory of Molecular Biology and Ada E. Yonath of the Weizmann Institute of Science. This article covers the historical context of Steitz's important discovery, the techniques his laboratory used to study the ribosome, and the impact that this research has had, and will have, on the future of biological and medical research.