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Sample records for professor daniel weinberger

  1. [The Danish psychiatrist and professor Daniel Jacobson (1861-1939) - as sketched by friends and patients].

    Science.gov (United States)

    Permin, Henrik; Therkelsen, Jørgen

    2004-01-01

    One of the nerve specialists/psychiatrists of the first part of the 20th. century, Professor Daniel Jacobson (1861-1939), chief physician of the Psychiatric Department, Frederiksberg Hospital, was an outstanding person as regards both character and appearance. He was a tall man, and his artistic looks and charismatic authority made him a popular therapist in the Scandinavian Countries. His patients included not only many devoted females, but also several Nordic artists - among these the Norwegian painter, Edvard Munch. Munch was treated in Jacobsons private nerve clinic at Frederiksberg in 1908-09 and during his stay he painted the characteristic portrait of Jacobson. Here we present a new collection of drawing, caricatures, verse and humorous texts from patients, colleagues and friends.

  2. Hartl, Prof. Daniel L

    Indian Academy of Sciences (India)

    Hartl, Prof. Daniel L. Date of birth: 1 January 1943. Address: Higgins Professor of Biology, Dept. of Organismic & Evolutionary, Biology, The Biological Lab., Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA Contact: Office: (+1-617) 496 3917. Email: dhartl@oeb.harvard.edu. YouTube; Twitter; Facebook; Blog ...

  3. Professing English a life of Roy Daniells

    CERN Document Server

    Djwa, Sandra

    2002-01-01

    Roy Daniells (1902-1979), an English professor who finished his career at the University of British Columbia, and an outstanding scholar, teacher and poet, influenced at least four generations of students.

  4. Steven Weinberg visits CERN

    CERN Multimedia

    2009-01-01

    Steven Weinberg visiting the ATLAS cavern accompanied by Peter JenniIt was no surprise that the CERN audience arrived early in the Globe of Science and Innovation for the colloquium on 7 July. Nobel laureate Steven Weinberg is one of the major contributors to the Standard Model of particle physics. He received the Nobel Prize for Physics in 1979 for his work on the unified theory of the electromagnetic and weak interactions, one of the essential pillars of the Standard Model. After lunch at CERN and a visit to ATLAS, Weinberg gave a colloquium on "The Quantum Theory of Fields: Effective or Fundamental" to a packed audience. In his talk, he looked at how the use of quantum field theory in particle physics has fluctuated in popularity since Paul Dirac first introduced the approach to describe the interaction of particles with electromagnetic fields in the late 1920s. In particular, he posed the question: Is quantum field theory fundamental or does it a...

  5. Nocera, Prof. Daniel G

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2013 Honorary. Nocera, Prof. Daniel G. Date of birth: 1957. Address: Dept. of Chemistry & Chem. Biol., Harvard University, 12, Oxford Street, Cambridge, MA 02138, USA Contact: Office: (+1-617) 495 8904. Email: dnocera@fas.harvard.edu. http://chemistry.harvard.edu/people/daniel-g-nocera.

  6. [Hardy-Weinberg equilibrium in genetic epidemiology].

    Science.gov (United States)

    Liu, Hong; Hu, Yonghua

    2010-01-01

    Hardy-Weinberg equilibrium test is the base of genetic epidemiology. The new methods for Hardy-Weinberg equilibrium test involve: X chromosome-linked single nucleotide polymorphism Hardy-Weinberg test, inbreeding coefficient (F) test, an incomplete enumeration algorithm for an exact test of Hardy-Weinberg proportions with multiple alleles, and graphical tests for Hardy-Weinberg equilibrium based on the ternary plot. It is necessary to conduct Hardy-Weinberg equilibrium test in genetic epidemiology studies and adjust the associations as deviation of Hardy-Weinberg equilibrium occurs.

  7. Bovet, Prof. Daniel

    Indian Academy of Sciences (India)

    Elected: 1967 Honorary. Bovet, Prof. Daniel Nobel Laureate (Medicine) - 1957. Date of birth: 23 March 1907. Date of death: 8 April 1992 ... Posted on 21 December 2017. ASTROPHYSICS: An Observational View of the Universe. Math Art and Design: MAD about Math, Math Education and Outreach. Math and Finance ...

  8. Dr. Daniel Carter

    Science.gov (United States)

    1998-01-01

    Dr. Daniel Carter, president of New Century Pharmaceuticals in Huntsville, Al, is one of three principal investigators in NASA's microgravity protein crystal growth program. Dr. Carter's experties is in albumins. Albumins are proteins in the bloodstream that transport materials, drugs, nutrients, and wastes. Photo credit: NASA/Marshall Space Flight Center

  9. The Hardy-Weinberg Principle

    Science.gov (United States)

    McMurran, Shawnee L.

    2010-01-01

    This module was initially developed for a course in applications of mathematics in biology. The objective of this lesson is to investigate how the allele and genotypic frequencies associated with a particular gene might evolve over successive generations. The lesson will discuss how the Hardy-Weinberg model provides a basis for comparison when…

  10. Portrait. Daniel Buren

    OpenAIRE

    Besson, Christian

    2012-01-01

    En 1987 paraisssait le premier livre consacré à Daniel Buren, celui de Catherine Francblin (Art Press), l’année suivante, l’important album des Photos-souvenirs (Villeurbanne). Jusque-là, pour une vue un tant soit peu générale sur le travail de l’artiste, on ne disposait que du catalogue Discordance/cohérence, rédigé par Rudi Fuchs. L’amateur devait collectionner les catalogues de galeries, institutions ou musées étrangers : Oxford (1973), Bruxelles (1974), Mönchengladbach, Lucerne, Berlin (1...

  11. Tribute to Daniel Simon

    CERN Multimedia

    2011-01-01

    Daniel Simon, PS Division Leader from 1994 to 1999, died on 2 June, 2011, at the age of 74, in Nancy. CERN owes him for a great number of contributions to the experimental areas around the PS and the existence of the Antiproton Decelerator (AD).   Daniel came to CERN in 1962 from the University of Nancy. He first worked in the Nuclear Physics Apparatus (NPA) Division on the electrostatic separators for the secondary beams at the PS, a subject he also chose for his thesis. Then, as a member of the PS-Division, he designed a variety of beam lines, including those providing protons and antiprotons to ICE, the decisive experiment for CERN to launch the antiproton project, based on stochastic cooling. His contributions to the initial layout and further evolution of the experimental areas of LEAR were essential for the success of the LEAR programme. He subsequently drove the decision and worked on the conversion of LEAR into LEIR for the provision of lead-ions to the LHC. He was one of the leaders of t...

  12. Kahevahel : Kui hajusad on kultuuriruumi piirid? / Anna Verschik, Tiina Kirss, Mikko Lagerspetz ; intervjueerinud Daniele Monticelli, Merle Karro-Kalberg

    Index Scriptorium Estoniae

    Verschik, Anna, 1968-

    2015-01-01

    Kultuurist, kultuuriruumist, kultuuris olemisest ja sealt pärinemisest arutlevad TLÜ professori Daniele Monticelli eestvõttel TLÜ professorid Anna Verschik ja Tiina Kirss ning Turu Åbo Akadeemia professor Mikko Lagerspetz

  13. A Reality check on Hardy-Weinberg

    National Research Council Canada - National Science Library

    Stark, Alan E; Seneta, Eugene

    2013-01-01

    G. H. Hardy (1877-1947) and Wilhelm Weinberg (1862-1937) had very different lives, but in the minds of geneticists, the two are inextricably linked through the ownership of an apparently simple law called the Hardy-Weinberg law...

  14. Testing Departure from Hardy-Weinberg Proportions.

    Science.gov (United States)

    Wang, Jian; Shete, Sanjay

    2017-01-01

    The Hardy-Weinberg principle, one of the most important principles in population genetics, was originally developed for the study of allele frequency changes in a population over generations. It is now, however, widely used in studies of human diseases to detect inbreeding, population stratification, and genotyping errors. For assessment of deviation from Hardy-Weinberg proportions in data, the most popular approaches include the asymptotic Pearson's chi-squared goodness-of-fit test and the exact test. Pearson's chi-squared goodness-of-fit test is simple and straightforward, but is very sensitive to a small sample size or rare allele frequency. The exact test of Hardy-Weinberg proportions is preferable in these situations. The exact test can be performed through complete enumeration of heterozygote genotypes or on the basis of the Markov chain Monte Carlo procedure. In this chapter, we describe the Hardy-Weinberg principle and the commonly used Hardy-Weinberg proportion tests and their applications, and we demonstrate how the chi-squared test and exact test of Hardy-Weinberg proportions can be performed step-by-step using the popular software programs SAS, R, and PLINK, which have been widely used in genetic association studies, along with numerical examples. We also discuss approaches for testing Hardy-Weinberg proportions in case-control study designs that are better than traditional approaches for testing Hardy-Weinberg proportions in controls only. Finally, we note that deviation from the Hardy-Weinberg proportions in affected individuals can provide evidence for an association between genetic variants and diseases.

  15. The Hyperreality of Daniel Boorstin

    Science.gov (United States)

    Viens, Stephanie L.

    2014-01-01

    Early media theorists can help us to link the past and present of media literacy to pose new questions and gain new knowledge. Historian, author and Librarian on Congress Daniel Boorstin (1914-2004) played an important role in increasing public awareness of the constructed nature of media representations. Connections are explored between…

  16. Exact Tests for Hardy-Weinberg Proportions

    National Research Council Canada - National Science Library

    Engels, William R

    2009-01-01

    Exact conditional tests are often required to evaluate statistically whether a sample of diploids comes from a population with Hardy-Weinberg proportions or to confirm the accuracy of genotype assignments...

  17. Teaching the Hardy-Weinberg Law

    Science.gov (United States)

    Dudley, B. A. C.

    1972-01-01

    Describes an approach to teaching the Hardy-Weinberg Law in high school genetics class. Instructional procedures used help in developing this concept in broad generalization form rather than merely a mathematical model of a gene pool. (PS)

  18. Daniel Brandt (1950-2014)

    CERN Multimedia

    2015-01-01

    It was with great sadness and emotion that we learnt of the death of our colleague and friend Daniel Brandt.   Throughout his career, Daniel was a faithful servant of the Organization, notably through his work as an expert in beam optics and collective effects. In particular, he contributed to the optimisation of the performance of LEP and later to theoretical studies on beam dynamics for the LHC. Daniel’s personal qualities made him a most pleasant colleague, always passionate and respectful. He tirelessly encouraged his students, giving them an excellent foundation in the field of accelerator physics to prepare them for their professional lives. The success and prospects of young physicists were a constant concern for him; in fact he believed they were absolutely essential. His commitment to students and his passion for quality teaching in accelerator physics were again in evidence in the years when Daniel was the head of the CERN Accelerator School (CAS), a role in which he s...

  19. Daniel Bois (1929-2008)

    CERN Document Server

    2008-01-01

    We were deeply saddened to hear of the death of our former colleague, Daniel Bois, at his home in Crozet on 27 March, in his 79th year. Daniel Bois, trained in precision mechanics, arrived at CERN in November 1954 and was assigned to the Central Workshop. His remarkable talent for precision measurements prompted his then boss to point him in the direction of the Survey Group, which was working on the construction of the PS at the time. He remained with this Group until he retired. His flair for measurements and his constant need to create and invent led him to fabricate novel tools for aligning the magnets of the PS or the ISR, even if this meant challenging the conventional methods of the day. One of his inventions was the "distinvar", a length-measuring tool that was widely used up until the construction of LEP. We are also indebted to Daniel for the use of stretched wires to align magnets, a technique that is still intensively ...

  20. Daniel Fromm 1949-2007

    CERN Multimedia

    2007-01-01

    It was with great sadness that we learned of the death in an accident of our friend and former colleague, Daniel Fromm, at the age of 58. Daniel arrived at CERN in 1968 to work on the alignment of the ISR magnets. After becoming a member of the personnel in 1975, he joined the R209 experiment in the 1980s, then the ALEPH experiment in 1994. He was a member of the PH-DT1 group from 2000 until his retirement in 2006. The name of Daniel Fromm is intimately linked to mass flowmeters. For over 15 years he managed the laboratory in Building 156 that was responsible for the calibration of flowmeters and technical support equipment for the gas racks used in the beams of the PS and SPS. The physicists from the LEP and fixed-target experiments placed blind trust in the accuracy and reliability of Daniel’s calibrations. They could be confident that a faulty flowmeter he repaired would be ready for use again in record time so that the detector could be immediately brought b...

  1. Wilhelm Weinberg's early contribution to segregation analysis.

    Science.gov (United States)

    Stark, Alan; Seneta, Eugene

    2013-09-01

    Wilhelm Weinberg (1862-1937) is a largely forgotten pioneer of human and medical genetics. His name is linked with that of the English mathematician G. H. Hardy in the Hardy-Weinberg law, pervasive in textbooks on population genetics since it expresses stability over generations of zygote frequencies AA, Aa, aa under random mating. One of Weinberg's signal contributions, in an article whose centenary we celebrate, was to verify that Mendel's segregation law still held in the setting of human heredity, contrary to the then-prevailing view of William Bateson (1861-1926), the leading Mendelian geneticist of the time. Specifically, Weinberg verified that the proportion of recessive offspring genotypes aa in human parental crossings Aa × Aa (that is, the segregation ratio for such a setting) was indeed p=1/4. We focus in a nontechnical way on his procedure, called the simple sib method, and on the heated controversy with Felix Bernstein (1878-1956) in the 1920s and 1930s over work stimulated by Weinberg's article.

  2. A reality check on Hardy-Weinberg.

    Science.gov (United States)

    Stark, Alan E; Seneta, Eugene

    2013-08-01

    G. H. Hardy (1877-1947) and Wilhelm Weinberg (1862-1937) had very different lives, but in the minds of geneticists, the two are inextricably linked through the ownership of an apparently simple law called the Hardy-Weinberg law. We demonstrate that the simplicity is more apparent than real. Hardy derived the well-known trio of frequencies {q 2, 2pq, p 2} with a concise demonstration, whereas for Weinberg it was the prelude to an ingenious examination of the inheritance of twinning in man. Hardy's recourse to an identity relating to the distribution of types among offspring following random mating, rather than an identity relating to the mating matrix, may be the reason why he did not realize that Hardy-Weinberg equilibrium can be reached and sustained with non-random mating. The phrase 'random mating' always comes up in reference to the law. The elusive nature of this phrase is part of the reason for the misunderstandings that occur but also because, as we explain, mathematicians are able to use it in a different way from the man-in-the-street. We question the unthinking appeal to random mating as a model and explanation of the distribution of genotypes even when they are close to Hardy-Weinberg proportions. Such sustained proportions are possible under non-random mating.

  3. A century of Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Mayo, Oliver

    2008-06-01

    Hardy-Weinberg equilibrium (HWE) is the state of the genotypic frequency of two alleles of one autosomal gene locus after one discrete generation of random mating in an indefinitely large population: if the alleles are A and a with frequencies p and q(=1-p), then the equilibrium gene frequencies are simply p and q and the equilibrium genotypic frequencies for AA, Aa and aa are p2, 2pq and q2. It was independently identified in 1908 by G. H. Hardy and W. Weinberg after earlier attempts by W. E. Castle and K. Pearson. Weinberg, well known for pioneering studies of twins, made many important contributions to genetics, especially human genetics. Existence of this equilibrium provides a reference point against which the effects of selection, linkage, mutation, inbreeding and chance can be detected and estimated. Its discovery marked the initiation of population genetics.

  4. On extending the Hardy-Weinberg law

    Directory of Open Access Journals (Sweden)

    Alan E. Stark

    2007-01-01

    Full Text Available This paper gives a general mating system for an autosomal locus with two alleles. The population reproduces in discrete and non-overlapping generations. The parental population, the same in both sexes, is arbitrary as is that of the offspring and the gene frequencies of the parents are maintained in the offspring. The system encompasses a number of special cases including the random mating model of Weinberg and Hardy. Thus it demonstrates, in the most general way possible, how genetic variation can be conserved in an indefinitely large population without invoking random mating or balancing selection. An important feature is that it provides a mating system which identifies when mating does and does not produce Hardy-Weinberg proportions among offspring.

  5. On extending the Hardy-Weinberg law

    OpenAIRE

    Stark,Alan E.

    2007-01-01

    This paper gives a general mating system for an autosomal locus with two alleles. The population reproduces in discrete and non-overlapping generations. The parental population, the same in both sexes, is arbitrary as is that of the offspring and the gene frequencies of the parents are maintained in the offspring. The system encompasses a number of special cases including the random mating model of Weinberg and Hardy. Thus it demonstrates, in the most general way possible, how genetic variati...

  6. Real and alleged problems for Daniels's account of health justice.

    Science.gov (United States)

    Kelleher, J Paul

    2013-08-01

    Norman Daniels's theory of health justice is the most comprehensive and systematic such theory we have. In one of the few articles published so far on Daniels's new book, Just Health, Benjamin Sachs argues that Daniels's core "principle of equality of opportunity does not do the work Daniels needs it to do." Yet Sachs's objections to Daniels's framework are deeply flawed. Where these arguments do not rely on significant misreadings of Daniels, they ignore sensible strands in Just Health that considerably dull their force. After disarming Sachs's arguments against Daniels's theory, I explain why I agree with Sachs's conclusion: Daniels's equality of opportunity-based account of health justice rests on shaky foundations.

  7. Johann Bernoulli Jacob Bernoulli Daniel Bernoulli

    Indian Academy of Sciences (India)

    Page 1. Licenced to post WPP(E) No.6. Johann Bernoulli. (1667-1748). Jacob Bernoulli. ( 1654-1705). Daniel Bernoulli. (1700-1782). Registered with Registrar of Newspapers in India vide Regn. No. 66273/96.

  8. A heterozygote–homozygote test of Hardy–Weinberg equilibrium

    OpenAIRE

    Zhou, Jin J; Lange, Kenneth; Papp, Jeanette C.; Sinsheimer, Janet S.

    2009-01-01

    The century-old Hardy–Weinberg law remains fundamental to population genetics. Typically Hardy–Weinberg equilibrium is tested in unrelated individuals using a χ2 goodness-of-fit test that compares expected and observed numbers of heterozygotes and homozygotes. In this report, we propose a likelihood ratio test for Hardy–Weinberg equilibrium that accommodates a mixture of pedigree and random sample data. The underlying statistical model depends on a parameter γ determining the ratio of heteroz...

  9. The Hardy-Weinberg Equilibrium--Some Helpful Suggestions.

    Science.gov (United States)

    Ortiz, Mary T.; Taras, Loretta; Stavroulakis, Anthea M.

    2000-01-01

    Describes an approach that provides mathematical tips and helpful suggestions for presenting the Hardy-Weinberg equilibrium to predict allele frequencies, phenotypes, and genotypes in populations. (ASK)

  10. Function of space in Daniel 1

    Directory of Open Access Journals (Sweden)

    Marius Nel

    2014-06-01

    Full Text Available Daniel 1 narrates how Daniel and his friends come from Jerusalem and are appointed as officials at the royal court in Babylon. The narrative is governed by the various and significant references to space. The Jews’ loyalty towards Jerusalem and its association with the Temple and temple cult is challenged by the loyalty required from them at the Babylonian court as symbolised by the new names they receive − names associated with the Babylonian gods. The strategy they devise to retain their loyalty towards YHWH is decided by their request for a specific specific type of food. Their eating special food in contrast to the royal food set apart for the candidates, creates a space that relates to the determinative contrast between Jerusalem and Shinar. The tale in Daniel 1 is determined by references to space that allowed the Jewish readers to understand its meaning.

  11. Symposium on Recent Advances in Experimental Mechanics : in honor of Isaac M. Daniel

    CERN Document Server

    2002-01-01

    This book contains 71 papers presented at the symposium on “Recent Advances in Experimental Mechanics” which was organized in honor of Professor Isaac M. Daniel. The symposium took place at Virginia Polytechnic Institute and State University on th June 23-28, 2002, in conjunction with the 14 US National Congress of Applied Mechanics. The book is a tribute to Isaac Daniel, a pioneer of experimental mechanics and composite materials, in recognition of his continuous, original, diversified and outstanding contributions for half a century. The book consists of invited papers written by leading experts in the field. It contains original contributions concerning the latest developments in experimental mechanics. It covers a wide range of subjects, including optical methods of stress analysis (photoelasticity, moiré, etc.), composite materials, sandwich construction, fracture mechanics, fatigue and damage, nondestructive evaluation, dynamic problems, fiber optic sensors, speckle metrology, digital image process...

  12. Daniel Bernoulli’s epidemiological model revisited

    NARCIS (Netherlands)

    Dietz, K.; Heesterbeek, J.A.P.

    2002-01-01

    The seminal paper by Daniel Bernoulli published in 1766 is put into a new perspective. After a short account of smallpox inoculation and of Bernoulli’s life, the motivation for that paper and its impact are described. It determines the age-specific equilibrium prevalence of immune individuals in an

  13. Daniel Radcliffe sirgub mister Potteriks / Timo Diener

    Index Scriptorium Estoniae

    Diener, Timo

    2003-01-01

    13-aastane inglise poiss Daniel Radcliff, kes mängib Harry Potterit ka J.K. Rowling'u Harry Potteri lugude teises filmis "Harry Potter ja saladuste kamber" ("Harry Potter and the Chamber of Secrets") : režissöör Chris Columbus : Ameerika Ühendriigid 2002

  14. Daniel Behailu Geberamanuel and Gemmeda Amelo Gurero ...

    African Journals Online (AJOL)

    1995-08-21

    Aug 21, 1995 ... HARAMAYA LAW REVIEW. Vol. 6 (2017). ISSN: 2227-2178 (P) & 2305-3739 (E). [43]. To cite this article: Daniel Behailu Geberamanuel and Gemmeda Amelo Gurero, The Enigma of. Informal Rural Land Deals In Ethiopia: Evidence from Peri-urban Areas of Hawassa City, HARAMAYA. LAW REVIEW 6 ...

  15. Daniele Monticellit köidab Eesti keeleuuendus / Daniele Monticelli ; küsitles Kristi Helme

    Index Scriptorium Estoniae

    Monticelli, Daniele, 1970-

    2007-01-01

    Intervjuu Tallinna Ülikooli Eesti Humanitaarinstituudi itaalia keele ja kultuuri õppejõu ja Tartu Ülikooli kontrastiivlingvistika teaduri ja semiootika doktorandi Daniele Monticelliga elust, haridusest, keelest ja kirjandusest

  16. Detecting selection-induced departures from Hardy-Weinberg proportions.

    Science.gov (United States)

    Lachance, Joseph

    2009-01-21

    Viability selection influences the genotypic contexts of alleles and leads to quantifiable departures from Hardy-Weinberg proportions. One measure of these departures is Wright's inbreeding coefficient (F), where observed heterozygosity is compared with expected heterozygosity. Here, I extend population genetics theory to describe post-selection genotype frequencies in terms of post-selection allele frequencies and fitness dominance. The resulting equations correspond to non-equilibrium populations, allowing the following questions to be addressed: When selection is present, how large a sample size is needed to detect significant departures from Hardy-Weinberg? How do selection-induced departures from Hardy-Weinberg vary with allele frequencies and levels of fitness dominance? For realistic selection coefficients, large sample sizes are required and departures from Hardy-Weinberg proportions are small.

  17. Detecting selection-induced departures from Hardy-Weinberg proportions

    Science.gov (United States)

    Lachance, Joseph

    2009-01-01

    Viability selection influences the genotypic contexts of alleles and leads to quantifiable departures from Hardy-Weinberg proportions. One measure of these departures is Wright's inbreeding coefficient (F), where observed heterozygosity is compared with expected heterozygosity. Here, I extend population genetics theory to describe post-selection genotype frequencies in terms of post-selection allele frequencies and fitness dominance. The resulting equations correspond to non-equilibrium populations, allowing the following questions to be addressed: When selection is present, how large a sample size is needed to detect significant departures from Hardy-Weinberg? How do selection-induced departures from Hardy-Weinberg vary with allele frequencies and levels of fitness dominance? For realistic selection coefficients, large sample sizes are required and departures from Hardy-Weinberg proportions are small. PMID:19284519

  18. Exact tests for Hardy-Weinberg proportions.

    Science.gov (United States)

    Engels, William R

    2009-12-01

    Exact conditional tests are often required to evaluate statistically whether a sample of diploids comes from a population with Hardy-Weinberg proportions or to confirm the accuracy of genotype assignments. This requirement is especially common when the sample includes multiple alleles and sparse data, thus rendering asymptotic methods, such as the common chi(2)-test, unreliable. Such an exact test can be performed using the likelihood ratio as its test statistic rather than the more commonly used probability test. Conceptual advantages in using the likelihood ratio are discussed. A substantially improved algorithm is described to permit the performance of a full-enumeration exact test on sample sizes that are too large for previous methods. An improved Monte Carlo algorithm is also proposed for samples that preclude full enumeration. These algorithms are about two orders of magnitude faster than those currently in use. Finally, methods are derived to compute the number of possible samples with a given set of allele counts, a useful quantity for evaluating the feasibility of the full enumeration procedure. Software implementing these methods, ExactoHW, is provided.

  19. Obituary: John Daniel Kraus, 1910-2004

    Science.gov (United States)

    Kraus, John D., Jr.; Marhefka, Ronald J.

    2005-12-01

    John Daniel Kraus, 94, of Delaware, Ohio, director of the Ohio State University "Big Ear" Radio Observatory, physicist, inventor, and environmentalist died 18 July 2004 at his home in Delaware, Ohio. He was born on 28 June 1910 in Ann Arbor, Michigan. He received a Bachelor of Science in 1930, a Master of Science in 1931, and a PhD in physics in 1933 (at 23 years of age), all from the University of Michigan, Ann Arbor. During the 1930s at Michigan, he was involved in physics projects, antenna consulting, and in atomic-particle-accelerator research using the University of Michigan's premier cyclotron. Throughout the late 1920s and the 1930s, John was an avid radio amateur with call sign W8JK. He was back on the air in the 1970s. In 2001 the amateur radio magazine CQ named him to the inaugural class of its Amateur Radio Hall of Fame. He developed many widely used innovative antennas. The "8JK closely spaced array" and the "corner reflector" were among his early designs. Edwin H. Armstrong wrote John in July 1941 indicating in part, "I have read with interest your article in the Proceedings of the Institute on the corner reflector...Please let me congratulate you on a very fine piece of work." Perhaps John's most famous invention, and a product of his intuitive reasoning process, is the helical antenna, widely used in space communications, on global positioning satellites, and for other applications. During World War II, John was in Washington, DC as a civilian scientist with the U.S. Navy responsible for "degaussing" the electromagnetic fields of steel ships to make them safe from magnetic mines. He also worked on radar countermeasures at Harvard University's Radio Research Laboratory. He received the U.S. Navy Meritorious Civilian Service Award for his war work. In 1946 he took a faculty position at Ohio State University, becoming professor in 1949, and retiring in 1980 as McDougal Professor Emeritus of Electrical Engineering and Astronomy. Even so, he never retired

  20. Roles of emeriti professors

    OpenAIRE

    Thody, Angela

    2008-01-01

    Emeritus Professor Angela Thody commenced a study of emeriti professors in 2006 when she herself had become an emeritus in 2003 and was seeking to establish an Association for emeriti at her university at Lincoln. By 2008, the literature review was finished and a pilot study of emeriti professors at Leicester University was underway. This presentation was one of several to the University of Lincoln's College of Professors to encourage their support for the formation of the association and to ...

  1. Obituary: Daniel E. Harris (1934 - 2015)

    Science.gov (United States)

    Madrid, Juan P.; Massaro, Francesco; Cheung, Teddy

    Our friend and colleague, Daniel E. Harris, died on December 6th 2015. Dan was a passionate astronomer and world traveller. He led a rich and scientifically productive life until the end. Dan was the first person to receive a PhD in radio astronomy at Caltech where he was a student of John Bolton, one of the fathers of Radio Astronomy and the founder of the Owens Valley Radio Observatory that Dan used for his thesis and first publications. One of Dan's first projects was with Jim Roberts to measure improved positions and flux densities for radio sources in the newly released 3C catalog. During this study, Dan discovered the first flat spectrum radio sources, which he named CTA 21, CTA 26, and CTA 102 and which were later identified as quasars. His PhD thesis resulted in the then definitive study of the evolution of supernova remnants. Later Dan worked on radio galaxies and active galactic nuclei (AGN) first at radio and then at X-ray wavelengths with the Einstein, ROSAT, and Chandra Observatories where he pioneered the new field of relativistic X-ray jets and how they relate to radio galaxies and AGN. After graduating from Caltech in 1961, Dan wanted to see the world. Beginning in 1962, Dan lived in Bologna, Italy, where he worked with Professor Marcello Ceccarelli and the radio astronomy group and was active in the construction of the Northern Cross Radio Observatory ("la Croce"), the first Italian radio telescope. He left Bologna in the Spring of 1964 as his friends remember him to "divenir del mondo esperto e de li vizi umani e del valore"1, as he joined V. Radhakrishnan (Rad) and Dave Morris to sail in a 36-ft trimaran from England to Puerto Rico where he took a position at the Arecibo Observatory working with Marshall Cohen on interplanetary scintillations. After five years at the Arecibo Observatory, Dan went on to work at the Argentinian Institute of Radio Astronomy, Harvard University, the Dwingeloo Radio Observatory in the Netherlands, and at the Dominion

  2. PROFESSOR ENSERMU KELBESSA

    African Journals Online (AJOL)

    2016-08-14

    Aug 14, 2016 ... University, Sweden in 1990. Although still very young, Professor Ensermu Kelbessa joined the Addis Ababa. University's Biology Department as a graduate assistant in 1979. He then went on to serve the university in various positions including: Lecturer, Assistant Professor, Associate. Professor and, finally ...

  3. Daniel Mato: una vida de interculturalidad

    Directory of Open Access Journals (Sweden)

    Alejandro Maldonado Fermín

    2011-04-01

    Full Text Available El presente artículo es una biografía intelectual necesariamente incompleta de uno de los autores latinoamericanos contemporáneos más emblemáticos y polémicos en el campo de los estudios sobre cultura, política y comunicación: Daniel Mato. Mediante el recorrido por algunos momentos clave de su vida y la manera como éstos guardan relación con sus obras, se ofrece una panorámica de este intelectual-activista, como forma de homenajear su trayectoria intelectual.

  4. Daniel Quinn and the Library of Babel

    Directory of Open Access Journals (Sweden)

    Leonardo Vieira de Almeida

    2011-06-01

    Full Text Available In “City of Glass”, Paul Auster's novel, the task of the detective and the reader mingle into the attempt to decipher an ever-drifting cartography. The city map on which Daniel Quinn must follow the clues of the Peter Stillman’s mystery becomes the space which represents the impossibility of any answer. To read New York is walking through a Babel of texts, a list of citations that disarticulate the city and Quinn in their quest for the incommunicable Name.

  5. A heterozygote-homozygote test of Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Zhou, Jin J; Lange, Kenneth; Papp, Jeanette C; Sinsheimer, Janet S

    2009-11-01

    The century-old Hardy-Weinberg law remains fundamental to population genetics. Typically Hardy-Weinberg equilibrium is tested in unrelated individuals using a chi(2) goodness-of-fit test that compares expected and observed numbers of heterozygotes and homozygotes. In this report, we propose a likelihood ratio test for Hardy-Weinberg equilibrium that accommodates a mixture of pedigree and random sample data. The underlying statistical model depends on a parameter gamma determining the ratio of heterozygous genotypes to homozygous genotypes among pedigree founders. As our heterozygous-homozygous test accommodates markers with dominant and recessive alleles, it can handle the phase ambiguities encountered in combining several linked single nucleotide polymorphisms into a single supermarker. No prior haplotyping is necessary. Our experience on real and simulated data suggests that the heterozygous-homozygous test has good type-one error and power.

  6. Daniel Kreig : ja budu sovsem drugim Dzheimsom Bondom / Daniel Craig ; interv. Mihhail Ozerov

    Index Scriptorium Estoniae

    Craig, Daniel

    2006-01-01

    Briti näitleja Daniel Craig on valitud kuuendaks James Bondi osatäitjaks. Ian Flemingi "Casino Royale" taasekraniseeringu režissöör on Martin Campbell. Lisaks lühike ülevaade Bondi kehastanud näitlejatest

  7. Monte Carlo algorithms for Hardy-Weinberg proportions.

    Science.gov (United States)

    Huber, Mark; Chen, Yuguo; Dinwoodie, Ian; Dobra, Adrian; Nicholas, Mike

    2006-03-01

    The Hardy-Weinberg law is among the most important principles in the study of biological systems. Given its importance, many tests have been devised to determine whether a finite population follows Hardy-Weinberg proportions. Because asymptotic tests can fail, Guo and Thompson developed an exact test; unfortunately, the Monte Carlo method they proposed to evaluate their test has a running time that grows linearly in the size of the population N. Here, we propose a new algorithm whose expected running time is linear in the size of the table produced, and completely independent of N. In practice, this new algorithm can be considerably faster than the original method.

  8. Stages in the evolution of the Hardy-Weinberg law

    OpenAIRE

    Stark,Alan E.

    2006-01-01

    The Hardy-Weinberg law has been used widely for about one hundred years with little question as to the foundations laid down by its originators. The basic assumption of random mating, that is choice of mates by a process akin to that of a lottery, was shown to produce genotypic proportions following the "binomial-square" rule, the so-called Hardy-Weinberg proportions (HWP). It has been assumed by many that random mating was the only way of pairing genes capable of producing HWP. However it ha...

  9. Professor Volker Claus: vom o. Professor zum e-Professor

    Science.gov (United States)

    Gunzenhäuser, Rul; Taras, Christiane; Wörner, Michael

    Der Beitrag würdigt das Wirken von Professor Claus auf Gebieten des rechnerunterstützten Lehrens. Dabei wird ein Bogen von den frühen Systemen des rechnerunterstützten Lehrens über moderne Lernplattformen im Internet zu neuen Anwendungen web-basierter Systeme für das lebenslange Lehren und Lernen gespannt.

  10. Maksumaksja raha sihtasutustes / Daniel Vaarik ; interv. Kristi Timmusk

    Index Scriptorium Estoniae

    Vaarik, Daniel, 1973-

    1999-01-01

    Rahandusministeeriumi nõunik Daniel Vaarik selgitab, kui palju raha erinevatesse sihtasutustesse eraldatakse ning kuidas kontrollitakse selle raha kasutamist. Tabel: 1999. a. riigieelarvest finantseeritavad sihtasutused

  11. Kõik on koreograafia / Daniel Linehan ; intervjueerinud Liina Luhats

    Index Scriptorium Estoniae

    Linehan, Daniel

    2011-01-01

    Intervjuu 12. rahvusvahelise Augusti tantsufestivali raames 21. augustil Kanuti Gildi saalis edenduvate lavastuste "Montage for Three" ja "Not About Everything" koreograafi ja tantsija Daniel Linehaniga

  12. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 2. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary Genetics - Incorporating Mutation and Migration. Amitabh Joshi. Series Article Volume 16 Issue 2 February 2011 pp 116-128 ...

  13. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary ...

    Indian Academy of Sciences (India)

    RESONANCE │ February 2011. SERIES │ ARTICLE. Hardy–Weinberg Equilibrium and the Foundations of. Evolutionary Genetics. 3. Incorporating Mutation and Migration. Amitabh Joshi. Keywords. Mutation, migration, gene flow, equilibrium, dynamics. Previous parts: Resonance, Vol.13: Part 1. The Dance of the Genes,.

  14. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 10. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary Genetics - The Inertial State in Population Genetics. Amitabh Joshi. Series Article Volume 13 Issue 10 October 2008 pp 951-970 ...

  15. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 9. Hardy–Weinberg Equilibrium and the Foundations of Evolutionary Genetics - The Dance of the Genes. Amitabh Joshi. Series Article Volume 13 Issue 9 September 2008 pp 812-835 ...

  16. Hardy-Weinberg law: asymptotic approach to a generalized form.

    Science.gov (United States)

    Stark, A E

    1976-09-17

    The equilibrium frequencies of a generalized Hardy-Weinberg law are approached at a geometric rate under assortative mating, irrespective of the initial genotypic frequencies. The asymptotic form is similar to that of Wright, and the pattern of assortative mating is based on deviations from the mean genotypic value.

  17. Testing Hardy-Weinberg equilibrium and homogeneity of Hardy-Weinberg disequilibrium using complex survey data.

    Science.gov (United States)

    Li, Yan; Graubard, Barry I

    2009-12-01

    For studies on population genetics, the use of representative random samples of the target population can avoid ascertainment bias. Genetic variation data from over a hundred genes were collected in a U.S. nationally representative sample in the Third National Health and Nutrition Examination Survey (NHANES III). Surveys such as the NHANES have complex stratified multistage cluster sample designs with sample weighting that can inflate variances and alter the expectations of test statistics. Thus, classical statistical tests of Hardy-Weinberg equilibrium (HWE) and homogeneity of HW disequilibrium (HHWD) for simple random samples are not suitable for data from complex samples. We propose using Wald tests for HWE and generalized score tests for HHWD that have been modified for complex samples. Monte Carlo simulation studies are used to investigate the finite sample properties of the proposed tests. Rao-Scott corrections applied to the tests were found to improve their type I error properties. Our methods are applied to the NHANES III genetic data for three loci involved in metabolizing lead in the body.

  18. Daniel Stufflebeam and The World Bank.

    Science.gov (United States)

    Russon, Craig; Russon, Karen

    2018-01-30

    Circa 2000 when The Evaluation Center on the campus of Western Michigan University was undergoing a renovation, staff were encouraged to clean out their filing cabinets. One of the authors rescued two manila files from the garbage dealing with a presentation that Daniel Stufflebeam made to The World Bank on 13 December 1993 and a subsequent World Bank conference on evaluation and development in which he participated 5-6 December 1994. In these documents, Dan set out some of his early thinking on international evaluation and other topics. The authors used these materials to write a tribute article to Dan publishing some of these ideas for the historical record. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. A Professor's Work.

    Science.gov (United States)

    Melko, Matthew

    This book describes a year-long participant-observer case study of the professorship as a profession. Following an introductory chapter, each chapter examines one aspect of the professor's occupation by recounting the specific experiences of the author, a sociology professor at Wright State University (Ohio). Chapter 2 looks at the department as…

  20. Vom Dämonischen. Zur politischen Medientheorie des Daniel Suarez

    Directory of Open Access Journals (Sweden)

    Alessandro Barberi

    2012-12-01

    Full Text Available Die Romane des Programmierers Daniel Suarez sind weit mehr als reine Fiktionen. Seine terminatorischen Inszenierungen des Endkampfs zwischen Maschinen und Menschen basieren auf äußerst realen Studien zu derzeitigen (Kriegs-Technologien, die als politische Steuerungsmedien eingesetzt werden.This is a review of Daniel Suarez's books Daemon (2009, Darknet (2011 and Kill Decision (2013.

  1. Daniel L. Schacter: Award for Distinguished Scientific Contributions

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents Daniel L. Schacter as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Daniel L. Schacter's major theoretical and empirical contributions include groundbreaking research on the psychological and neural foundations of implicit and explicit memory, memory distortions and…

  2. Alexander von Humboldt in Daniel Kehlmanns Welt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2012-12-01

    Full Text Available Zusammenfassung Wie stark sich im Verlauf des zurückliegenden Vierteljahrhunderts der Bekanntheitsgrad Alexander von Humboldts in der deutschsprachigen Öffentlichkeit verändert hat, zeigen nicht nur Fernsehumfragen zu den berühmtesten Deutschen, in denen Alexander von Humboldt mittlerweile figuriert, oder Fernsehserien, die über aktuelle Expeditionen berichten und auf Humboldts Namen zurückgreifen. Am deutlichsten vielleicht belegt dies der enorme Erfolg von Daniel Kehlmanns Roman Die Vermessung der Welt, der ohne die zuvor skizzierte Entwicklung nicht denkbar gewesen wäre. Es ist vor diesem Hintergrund nicht nur reizvoll, sondern aufschlußreich, sich mit dem großen Erfolg dieses kleinen Romans zu beschäftigen. Worum geht es in Die Vermessung der Welt? Und wie läßt sich das „Phänomen Kehlmann“ aus etwas größerer Distanz erklären? Abstract In the last 25 years, Alexander von Humboldt‘s popularity has radically changed in the german-speaking public opinion. Proof of this are not only television surveys about the most famous germans - in which Alexander von Humboldt now regularly figures - or television series about contemporary expeditions, which constantly refer to Humboldt‘s name; perhaps what most clearly verifies this change is the great success of Daniel Kehlmann‘s novel Die Vermessung der Welt. Without the recent developments outlined above, this novel‘s degree of impact would have been unimaginable. To study the great success of this text against this backdrop is not only attractive, but also revealing. What is Die Vermessung der Welt really about? And how can we explain the „Kehlmann phenomenon“ from a greater distance? Resumen La popularidad de Alejandro de Humboldt ha cambiado profundamente dentro del último cuarto de siglo en la opinión pública de habla alemana. Prueba de esto son no sólo las encuestas televisivas sobre los alemanes más famosos, dentro de las cuales figura en estos momentos Alejandro

  3. Advances in complex analysis and operator theory festschrift in honor of Daniel Alpay’s 60th birthday

    CERN Document Server

    Sabadini, Irene; Struppa, Daniele; Vajiac, Mihaela

    2017-01-01

    This book gathers contributions written by Daniel Alpay’s friends and collaborators. Several of the papers were presented at the International Conference on Complex Analysis and Operator Theory held in honor of Professor Alpay’s 60th birthday at Chapman University in November 2016. The main topics covered are complex analysis, operator theory and other areas of mathematics close to Alpay’s primary research interests. The book is recommended for mathematicians from the graduate level on, working in various areas of mathematical analysis, operator theory, infinite dimensional analysis, linear systems, and stochastic processes.

  4. Professor Martin Hairer

    Directory of Open Access Journals (Sweden)

    Martine Barons

    2015-09-01

    Full Text Available Professor Martin Hairer was one of four recipients of the 2014 Fields Medal, widely viewed as the highest honour a mathematician can receive. He is currently Regius Professor of Mathematics in the Mathematics Department at the University of Warwick. Professor Hairer has contributed significantly to the field of stochastic partial differential equations (SPDEs, which engages with interdisciplinary approaches to mathematics and physics. He has enjoyed great success communicating mathematics to a range of audiences and has also developed music editing software.In this interview, early career mathematicians, Dr Martine Barons (MJB and Dr Paul Chleboun ask Professor Hairer (MH about how his interest in mathematics developed; the awards ceremony where he received the Fields Medal; Amadeus Pro, the music software he developed and continues to maintain; and the challenges of engaging a sceptical and sometimes critical public as a mathematician.

  5. On introduction of additional gauge fields in the Weinberg model

    CERN Document Server

    Dolgov, A D; Okun, Lev Borisovich

    1973-01-01

    Introduction of new gauge fields in the Weinberg model makes it possible to realize locally all lepton symmetries of the Lagrangian. This procedure does not result in any contradiction between the experimentally observed conservation of the leptonic charge of leptons and the fact that a vector meson interacting with a leptonic charge becomes massive after spontaneous symmetry breaking. It is shown that in theories with a minimum number of scalar bosons (at a given number of vector bosons) the nu /sub mu /e axial constant g/sub A/ is still -/sup 1///sub 2/ as in the Weinberg model but in this case the variation range of the vector constant is more broad. The value g/sub A/ is not fixed in models with an excess of scalar fields. The practical method for diagonalizing the Lagrangian after spontaneous symmetry breaking is considered in detail. (6 refs).

  6. Testing Hardy-Weinberg equilibrium: an objective Bayesian analysis.

    Science.gov (United States)

    Consonni, Guido; Moreno, Elías; Venturini, Sergio

    2011-01-15

    We analyze the general (multiallelic) Hardy-Weinberg equilibrium problem from an objective Bayesian testing standpoint. We argue that for small or moderate sample sizes the answer is rather sensitive to the prior chosen, and this suggests to carry out a sensitivity analysis with respect to the prior. This goal is achieved through the identification of a class of priors specifically designed for this testing problem. In this paper, we consider the class of intrinsic priors under the full model, indexed by a tuning quantity, the training sample size. These priors are objective, satisfy Savage's continuity condition and have proved to behave extremely well for many statistical testing problems. We compute the posterior probability of the Hardy-Weinberg equilibrium model for the class of intrinsic priors, assess robustness over the range of plausible answers, as well as stability of the decision in favor of either hypothesis. Copyright © 2010 John Wiley & Sons, Ltd.

  7. Testing the Hardy-Weinberg equilibrium in the HLA system.

    Science.gov (United States)

    Eguchi, S; Matsuura, M

    1990-06-01

    A new method of testing the Hardy-Weinberg equilibrium in the human leukocyte antigen (HLA) system is proposed and applied to real data. The derivation is based on the maximum likelihood method and closely related to standard regression theory. The test statistic has a closed representation of residual sum of squares by a projection mapping of data onto the estimated regression plane. Under the Hardy-Weinberg law the noniterative estimates for the gene frequencies are suggested by the use of the projection mapping. The test statistic and gene frequency estimates are shown to be asymptotically equivalent to the maximum likelihood method and to be more efficient than the other suggested test statistic when there are more than two identified alleles.

  8. Stages in the evolution of the Hardy-Weinberg law

    Directory of Open Access Journals (Sweden)

    Alan E. Stark

    2006-01-01

    Full Text Available The Hardy-Weinberg law has been used widely for about one hundred years with little question as to the foundations laid down by its originators. The basic assumption of random mating, that is choice of mates by a process akin to that of a lottery, was shown to produce genotypic proportions following the "binomial-square" rule, the so-called Hardy-Weinberg proportions (HWP. It has been assumed by many that random mating was the only way of pairing genes capable of producing HWP. However it has been shown that HWP can be obtained and maintained by non-random mating. The steps along the way to this revelation and some implications are reviewed.

  9. Distributions of Hardy-Weinberg equilibrium test statistics.

    Science.gov (United States)

    Rohlfs, R V; Weir, B S

    2008-11-01

    It is well established that test statistics and P-values derived from discrete data, such as genetic markers, are also discrete. In most genetic applications, the null distribution for a discrete test statistic is approximated with a continuous distribution, but this approximation may not be reasonable. In some cases using the continuous approximation for the expected null distribution may cause truly null test statistics to appear nonnull. We explore the implications of using continuous distributions to approximate the discrete distributions of Hardy-Weinberg equilibrium test statistics and P-values. We derive exact P-value distributions under the null and alternative hypotheses, enabling a more accurate analysis than is possible with continuous approximations. We apply these methods to biological data and find that using continuous distribution theory with exact tests may underestimate the extent of Hardy-Weinberg disequilibrium in a sample. The implications may be most important for the widespread use of whole-genome case-control association studies and Hardy-Weinberg equilibrium (HWE) testing for data quality control.

  10. Fluor Daniel Hanford contract standards/requirements identification document

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, G.L.

    1997-04-24

    This document, the Standards/Requirements Identification Document (S/RID) for the Fluor Daniel Hanford Contract, represents the necessary and sufficient requirements to provide an adequate level of protection of the worker, public health and safety, and the environment.

  11. Daniel K. Inouye Solar Telescope system safety

    Science.gov (United States)

    Hubbard, Robert P.; Bulau, Scott E.; Shimko, Steve; Williams, Timothy R.

    2014-08-01

    System safety for the Daniel K. Inouye Solar Telescope (DKIST) is the joint responsibility of a Maui-based safety team and the Tucson-based systems engineering group. The DKIST project is committed to the philosophy of "Safety by Design". To that end the project has implemented an aggressive hazard analysis, risk assessment, and mitigation system. It was initially based on MIL-STD-882D, but has since been augmented in a way that lends itself to direct application to the design of our Global Interlock System (GIS). This was accomplished by adopting the American National Standard for Industrial Robots and Robot Systems (ANSI/RIA R15.06) for all identified hazards that involve potential injury to personnel. In this paper we describe the details of our augmented hazard analysis system and its use by the project. Since most of the major hardware for the DKIST (e.g., the enclosure, and telescope mount assembly) has been designed and is being constructed by external contractors, the DKIST project has required our contractors to perform a uniform hazard analysis of their designs using our methods. This paper also describes the review and follow-up process implemented by the project that is applied to both internal and external subsystem designs. Our own weekly hazard analysis team meetings have now largely turned to system-level hazards and hazards related to specific tasks that will be encountered during integration, test, and commissioning and maintenance operations. Finally we discuss a few lessons learned, describing things we might do differently if we were starting over today.

  12. Professor Michael Levitt

    Directory of Open Access Journals (Sweden)

    Gemma-Louise Davies

    2015-10-01

    Full Text Available Professor Michael Levitt (Stanford University, USA won the 2013 Nobel Prize in Chemistry for the development of multiscale models for complex chemical systems—computational tools which can calculate the course of chemical reactions. Professor Levitt was born in Pretoria, South Africa; he came to the UK on a summer vacation aged 16, where he decided to stay and study for his A‑levels. His interest in the physics of living systems drove him to study biophysics at King’s College London, before securing a PhD position at the Laboratory of Molecular Biology in Cambridge. In the interim year between his degree and beginning his PhD, Professor Levitt worked at the Weizmann Institute of Science in Israel, where he met his future wife. They married later that year and moved to Cambridge, where their three children were born. After completing his PhD, he spent time working in Israel, Cambridge, the Salk Institute and Stanford (both California. Since 1986, he has split his time between Israel and California. Outside of science, he is a keen hiker and he is well-known to have attended the eclectic ‘Burning Man’ Festival in California.[1]Professor Levitt visited the University of Warwick to speak at the Computational Molecular Science Annual Conference in March 2015. In this interview, Dr Gemma-Louise Davies, an Institute of Advanced Study Global Research Fellow, spoke to Professor Levitt about the importance of Interdisciplinarity in his field, role models in Academia, and his plans for the future.Image: Professor Michael Levitt (left with Dr Scott Habershon (right, organiser of the 2015 Computational Molecular Science Annual Conference during his visit to the University of Warwick in March 2015.[1] ‘Burning Man’ is a unique annual festival dedicated to community, art, music, self-expression and self-reliance. Tens of thousands of people flock to this temporary metropolis built in the Californian desert.

  13. Rational inferences about departures from Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Wittke-Thompson, Jacqueline K; Pluzhnikov, Anna; Cox, Nancy J

    2005-06-01

    Previous studies have explored the use of departure from Hardy-Weinberg equilibrium (DHW) for fine mapping Mendelian disorders and for general fine mapping. Other studies have used Hardy-Weinberg tests for genotyping quality control. To enable investigators to make rational decisions about whether DHW is due to genotyping error or to underlying biology, we developed an analytic framework and software to determine the parameter values for which DHW might be expected for common diseases. We show analytically that, for a general disease model, the difference between population and Hardy-Weinberg expected genotypic frequencies (delta) at the susceptibility locus is a function of the susceptibility-allele frequency (q), heterozygote relative risk (beta), and homozygote relative risk (gamma). For unaffected control samples, is a function of risk in nonsusceptible homozygotes (alpha), the population prevalence of disease (KP), q, beta, and gamma. We used these analytic functions to calculate and the number of cases or controls needed to detect DHW for a range of genetic models consistent with common diseases (1.1 < or = gamma < or = 10 and 0.005 < or = KP < or = 0.2). Results suggest that significant DHW can be expected in relatively small samples of patients over a range of genetic models. We also propose a goodness-of-fit test to aid investigators in determining whether a DHW observed in the context of a case-control study is consistent with a genetic disease model. We illustrate how the analytic framework and software can be used to help investigators interpret DHW in the context of association studies of common diseases.

  14. Estimation of divergence from Hardy-Weinberg form.

    Science.gov (United States)

    Stark, Alan E

    2015-08-01

    The Hardy–Weinberg (HW) principle explains how random mating (RM) can produce and maintain a population in equilibrium, that is, with constant genotypic proportions. When proportions diverge from HW form, it is of interest to estimate the fixation index F, which reflects the degree of divergence. Starting from a sample of genotypic counts, a mixed procedure gives first the orthodox estimate of gene frequency q and then a Bayesian estimate of F, based on a credible prior distribution of F, which is described here.

  15. A Clarification of the Hardy–Weinberg Law

    OpenAIRE

    Stark,Alan E.

    2006-01-01

    C. C. Li showed that Hardy–Weinberg proportions (HWP) can be maintained in a large population by nonrandom mating as well as random mating. In particular he gave the mating matrix for the symmetric case in the most general form possible. Thus Li showed that, once HWP are attained, the same proportions can be maintained by what he called pseudorandom mating. This article shows that, starting from any genotypic distribution at a single locus with two alleles, the same in each sex, HWP can be re...

  16. Professor Kalkman retires

    NARCIS (Netherlands)

    Baas, Pieter

    1991-01-01

    On 13 December 1990 Prof. Dr. Cornelis (Kees) Kalkman retired from the positions of Professor of Plant Systematics and Scientific Director of the Rijksherbarium/ Hortus Botanicus by presenting his valedictory lecture to the academic community of Leiden University and the assembled Dutch Botanical

  17. Professor Wolfgang Panofsky

    CERN Multimedia

    2007-01-01

    "Professor Wolfgang panofsky, who died on September 24 aged 88, was a particle physicists and director of the Stanford Linear Accelerator Centre (SLAC) in California; with Jack Steinberger, he was the first to isolate the neutral pi meson, one of the subatomic particles which had been predicted by theoretical scientists to account for the strng force which binds the nuclei of atoms." (1 page)

  18. Professor Tiina Tasmuth Helsingis

    Index Scriptorium Estoniae

    2000-01-01

    Tervisekasvatuse õppetooli professor Tiina Tasmuth osales 11.-14. juunini Helsingis toimunud rahvusvahelise konverentsi "2nd Psycho-Social Impacts of Breast Cancer" töös ning esines ettekandega teemal "Chronic post-treatment symptoms in patients with breast cancer" : [täistekst

  19. Professor og DMI

    DEFF Research Database (Denmark)

    Kaas, Eigil

    2010-01-01

    oplever meget lave temperaturer - og for Danmarks vedkommende en usædvanlig lang periode med vintervejr. Forklaringen kommer fra professor Eigil Kaas fra Niels Bohr Instituttet ved Københavns Universitet. Han forklarer til jp.dk, at vintervejret dog er betinget af den mere eller mindre tilfældige måde...

  20. Professors' Observations on Their Work.

    Science.gov (United States)

    Myers, Betty; Mager, Gerald M.

    Previous studies of professors of education have noted what activities comprised the work of being a professor, how professors allocated time to the various work tasks, how they would have preferred to allocate time, and insights they had about their work. In this study, parallel data were gathered on the broader education professoriate. Survey…

  1. Exploring Ghost Worlds: A Review of 'The Daniel Clowes Reader'

    Directory of Open Access Journals (Sweden)

    Paddy Johnston

    2013-09-01

    Full Text Available Daniel Clowes is undoubtedly one of the most influential and prolific cartoonists working today, with a career spanning many decades. 'The Daniel Clowes Reader' (Parille 2013 comes at the perfect time – when interest in Clowes from scholars and critics is at a high, but in which he is still perhaps given less critical attention than his peers Chris Ware, Art Spiegelman, and Marjane Satrapi, all of whom are cited twice as often as Clowes despite his large canon of significant works in comics. With recent books being published on Chris Ware by The University Press of Mississippi and the forthcoming Art Spiegelman collection from Drawn and Quarterly, more significant focused, monographic books are emerging in comics and comics criticism, and 'The Daniel Clowes Reader' is a more than welcome addition to this emergence.

  2. Memorial meeting for professor Abdus Salam's 90th birthday

    CERN Document Server

    Duff, Michael; Khoo Phua, Kok; Memorial volume on Abdus Salam's 90th birthday

    2017-01-01

    In honor of one of the most prolific and exciting scientists of the second half of the last century, a memorial meeting was organized by the Institute of Advanced Studies at Nanyang Technological University for Professor Abdus Salam's 90th Birthday in January 2016. Salam believed that "scientific thought is the common heritage of all mankind" and that the developing world should play its part, not merely by importing technology but by being the arbiter of its own scientific destiny. That belief saw him rise from humble beginnings in a village in Pakistan to become one of the world's most original and influential particle physicists, culminating in the 1979 Nobel Prize (shared with Glashow and Weinberg) for contributions to electroweak unification, which forms an integral part of the Standard Model. The book collected the papers presented at this memorable event which saw many distinguished scientists participating as speakers to reflect on Prof Salam's great passion for the science and achievements.

  3. A Lab Exercise Explaining Hardy-Weinberg Equilibrium and Evolution Effectively.

    Science.gov (United States)

    Winterer, Juliette

    2001-01-01

    Presents a set of six activities in population genetics for a college-level biology course that helps students understand the Hardy-Weinberg principle. Activities focus on characterizing a population, Hardy-Weinberg proportions, genetic drift, mutation and selection, population size and divergence, and secondary contact. The only materials…

  4. Using an Algorithm When Solving Hardy-Weinberg Problems in Biology.

    Science.gov (United States)

    Stencel, John E.

    1991-01-01

    A real world sample of actual data that students can use to see the application of the Hardy-Weinberg law to a real population is provided. The directions for using a six-step algorithmic procedure to determine Hardy-Weinberg percentages on the data given are described. (KR)

  5. Rethinking Hardy-Weinberg and genetic drift in undergraduate biology.

    Science.gov (United States)

    Masel, Joanna

    2012-08-01

    Population genetics is often taught in introductory biology classes, starting with the Hardy-Weinberg principle (HWP) and genetic drift. Here I argue that teaching these two topics first aligns neither with current expert knowledge, nor with good pedagogy. Student difficulties with mathematics in general, and probability in particular, make population genetics difficult to teach and learn. I recommend an alternative, historically inspired ordering of population genetics topics, based on progressively increasing mathematical difficulty. This progression can facilitate just-in-time math instruction. This alternative ordering includes, but does not privilege, the HWP and genetic drift. Stochastic events whose consequences are felt within a single generation, and the deterministic accumulation of the effects of selection across multiple generations, are both taught before tackling the stochastic accumulation of the effects of accidents of sampling. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Testing Hardy-Weinberg disequilibrium using the generalized linear model.

    Science.gov (United States)

    Xu, Shizhong

    2012-12-01

    Current methods for detecting Hardy-Weinberg disequilibrium (HWD) only deal with one locus at a time. We developed a method that can jointly detect HWD for multiple loci. The method was developed under the generalized linear model (GLM) using the probit link function. When applied to a single locus, the new method is more powerful than the exact test. When applied to two or more loci, the method can reduce false positives caused by linkage disequilibrium (LD). We applied the method to 24 single nucleotide polymorphism (SNP) markers of a single human gene and eliminated several false positive HWDs due to LD. We developed an R package 'hwdglm' for joint HWD detection, which can be downloaded from our personal website (www.statgen.ucr.edu).

  7. Testing for linkage and Hardy-Weinberg disequilibrium.

    Science.gov (United States)

    Kulinskaya, E; Lewin, A

    2009-03-01

    This paper concerns several important points when testing for Hardy-Weinberg equilibrium (HWE) and linkage disequilibrium (LD) in genetics. First, we challenge the necessity of using exclusively two-sided tests for LD. Next, we show that the exact 2-sided tests based on the most popular measures of LD are not equivalent, and neither are the standard statistical tests even though the 1-sided tests are equivalent. We show how this results in different inference about LD for two data sets consisting of small groups of markers. Finally, we advocate the use of the conditional p-value for both LD and HWE testing. An important advantage of this p-value is that equivalent 1-sided tests are transformed into equivalent 2-sided tests.

  8. An exact test of the Hardy-Weinberg law.

    Science.gov (United States)

    Chapco, W

    1976-03-01

    An exact distribution of a finite sample drawn from an infinite population in Hardy-Weinberg Equilibrium is described for k-alleles. Accordingly, an exact test of the law is presented and compared with two x2-tests for two and three alleles. For two alleles, it is shown that the "classical" c2-test is very adequate for sample sizes as small as ten. For three alleles, it is shown that a simpler formulation based on Leven's distribution approximates the exact test of this paper rather closely. However, it is recommended that researchers continue to employ the standard x2-test for all sample sizes and abide by it if the corresponding probability value is not "too close" to the critical level; otherwise, an exact test should be used.

  9. A clarification of the Hardy-Weinberg law.

    Science.gov (United States)

    Stark, Alan E

    2006-11-01

    C. C. Li showed that Hardy-Weinberg proportions (HWP) can be maintained in a large population by nonrandom mating as well as random mating. In particular he gave the mating matrix for the symmetric case in the most general form possible. Thus Li showed that, once HWP are attained, the same proportions can be maintained by what he called pseudorandom mating. This article shows that, starting from any genotypic distribution at a single locus with two alleles, the same in each sex, HWP can be reached in one round of nonrandom mating with no change in allele frequency. In the model that demonstrates this fact, random mating is represented by a single point in a continuum of nonrandom possibilities.

  10. Testing the Hardy-Weinberg law across strata.

    Science.gov (United States)

    Olson, J M

    1993-10-01

    The problem of testing the Hardy-Weinberg law when data are sampled from several populations with different allele frequencies is considered. An odds-ratio representation of disequilibrium is proposed. This ratio is assumed to be constant across strata, an assumption that seems more reasonable than that of previous authors of a constant difference in true and expected (under equilibrium) heterozygote proportions. A score-type test which optimally combines information from the separate strata is then derived using the theory of unbiased estimating equations. Simulations show that the new test has greater power than previously proposed tests when the disequilibrium ratio is constant across strata. The method is applied to glyoxalase genotype data from populations in India.

  11. A clash of gods – Conceptualising space in Daniel 1

    African Journals Online (AJOL)

    2014-02-25

    Feb 25, 2014 ... of the narrative without interpreting the narrative as a whole within ..... The battle of the banquet is, however, only a preparation for a much tougher ... The book of Daniel was written to guide the Jews who lived under the rule of ...

  12. In memoriam Prof. Dr. Leo Daniel Brongersma (1907-1994)

    NARCIS (Netherlands)

    Hoogmoed, M.S.

    1995-01-01

    A biography of Leo Daniel Brongersma is given, highlighting his significance for herpetology worldwide, and especially for snake anatomy, sea turtle distribution, faunistics of New Guinea and IndoAustralia. Lists of patronyms, of species named by Brongersma and of his publications are given. Also

  13. A clash of gods – Conceptualising space in Daniel 1

    African Journals Online (AJOL)

    2014-02-25

    Feb 25, 2014 ... long-standing popularity of the Star Trek science fiction franchise. This phrase emphasised man's desire to ..... represents the cosmological balance that was created by. Yahweh when he created heaven and ... the ten-day test, Daniel and his friends are not only healthier than the other young men, they are ...

  14. Blond Bond Daniel Craig tungib buldooserina edasi / Triin Tael

    Index Scriptorium Estoniae

    Tael, Triin

    2006-01-01

    Uus Bondi-film "007: Casino Royale" esilinastus Londonis 17. novembril, režissööriks Martin Campbell. Lisaks sõnum "Elizabeth II jäi Bondile truuks", ülevaade "James Bond läbi aegade" ja peaosatäitja lühitutvustus "Daniel Craig"

  15. Balti riikide vabadus ei ohusta Venemaad / Daniel Fried

    Index Scriptorium Estoniae

    Fried, Daniel, 1952-

    2007-01-01

    Ilmunud ka: The Baltic Times, 21. juuni 2007, lk. 15. Ameerika Ühendriikide asevälisminister Euroopa ja Euraasia asjus Daniel Fried Balti riikide tunnustamisest, vabadusest ja suveräänsusest. Venemaa huvides on olla ümbritsetud rahulikest ja jõukatest demokraatiatest, ähvardustele ja sanktsioonidele ei tohi jätta ruumi

  16. Daniel Webster Middle School: More than Cosmetic Improvements

    Science.gov (United States)

    Rourke, James; Boone, Elizabeth

    2009-01-01

    "Webster needs an extreme makeover," students told Principal Joan Brixey upon her arrival at Daniel Webster Middle School in Waukegan, Illinois, three short years ago. The message came in a student-produced video that highlighted things that needed repair at Webster. Brixey was already a firm believer in the proposition that students…

  17. Daniel Day-Lewis - veri peab voolama / Kristiina Davidjants

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2008-01-01

    Iiri-juudi näitleja Daniel Day-Lewis, kes võitis oma rolliga P.T. Andersoni filmis "Veri hakkab voolama" parima meespeaosatäitja Oscari. Tema põhjalikust tööst rollidega läbi tema filmiloomingu

  18. Galvexi terasekuningas / Daniel Brain ; interv. Toivo Tänavsuu

    Index Scriptorium Estoniae

    Brain, Daniel

    2003-01-01

    Galvex Estonia juht Daniel Brain vastab küsimusetele, mis puudutavad toorterase toomist USA-st, Galvexi kliente, ettevõttega seotud skandaale, meedias esitatud süüdistust metallivarguse kohta ettevõttes. Vt. samas: Eesti hakkas meeldima. Lisa: Galvex

  19. Former IDRC grantee Daniel Hillel wins World Food Prize | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-05-26

    May 26, 2016 ... Daniel Hillel, who pioneered an innovative way of bringing water to crops in arid and dry-land regions, was named the winner of the 2012 World Food Prize. The announcement was made in Washington where US Secretary of State Hillary Clinton described Hillel as understanding "the critical role water ...

  20. Professor Stewart's incredible numbers

    CERN Document Server

    Stewart, Ian

    2015-01-01

    Ian Stewart explores the astonishing properties of numbers from 1 to10 to zero and infinity, including one figure that, if you wrote it out, would span the universe. He looks at every kind of number you can think of - real, imaginary, rational, irrational, positive and negative - along with several you might have thought you couldn't think of. He explains the insights of the ancient mathematicians, shows how numbers have evolved through the ages, and reveals the way numerical theory enables everyday life. Under Professor Stewart's guidance you will discover the mathematics of codes,

  1. President Meri näitas USA-le vabaduse ilu / Daniel Fried ; interv. Kaarel Kaas

    Index Scriptorium Estoniae

    Fried, Daniel, 1952-

    2006-01-01

    USA abivälisminister Daniel Fried USA välispoliitika ühest eesmärgist - demokraatia levitamisest maailmas, demokraatia olukorrast Venemaal ning USA ja Venemaa vahelistest suhetest. Lisa: Daniel Fried

  2. Professor Alex Callinicos

    Directory of Open Access Journals (Sweden)

    Ali Saqer

    2016-04-01

    Full Text Available Professor Alex Callinicos is a renowned social theorist and scholar of international political economy. He conducts research on Marx and Marxism, European social and political theory, contemporary political philosophy, critical theory, historiography, and international political economy. His work provides invaluable insights on issues of race and racism, social justice, the Third Way, imperialism, austerity, and EU politics, among many other fascinating contemporary issues. Alex studied Philosophy, Politics, and Economics at Balliol College, Oxford, and Philosophy of Science at the London School of Economics before writing a DPhil on Marx's Capital, also at Balliol. He was a Junior Research Fellow in Contemporary Social Thought at St Peter's College, Oxford from 1979 to 1981, after which he taught social and political theory at the Department of Politics at the University of York until 2005, when he moved to King's College London. Alex is currently the Professor of European Studies at King's and editor of International Socialism. Alex has been an active contributor to the development of the movement for another globalization, participating in the World Social Forum and an animator of the European Social Forum. Among his best known books are The Revolutionary Ideas of Karl Marx (1983, Against Postmodernism (1990, Social Theory (1999, An Anti-Capitalist Manifesto (2003, The Resources of Critique (2006, Imperialism and Global Political Economy (2009. His most recent book is entitled Deciphering Capital: Marx’s Capital and its Destiny (2014.

  3. 77 FR 13625 - Notice of Inventory Completion: USDA Forest Service, Daniel Boone National Forest, Winchester, KY

    Science.gov (United States)

    2012-03-07

    ... National Park Service Notice of Inventory Completion: USDA Forest Service, Daniel Boone National Forest... Agriculture, Forest Service, Daniel Boone National Forest, has completed an inventory of human remains and... contact the Daniel Boone National Forest, Winchester, KY. Repatriation of the human remains to the Indian...

  4. Daniel Fried peab Euroopa vastust Gruusia sõjale tugevaks / Evelyn Kaldoja

    Index Scriptorium Estoniae

    Kaldoja, Evelyn, 1980-

    2008-01-01

    Eestit külastanud USA asevälisminister Daniel Fried leidis, et Euroopa reaktsioon Gruusias toimunule oli tugev ja efektiivne. Daniel Fried kohtus president Toomas Hendrik Ilvese, peaminister Andrus Ansipi ja välisminister Urmas Paetiga. Vt. samas: Daniel Fried: CV

  5. Voorwoord: Professor Andrzej Borowski

    Directory of Open Access Journals (Sweden)

    Koch Jerzy

    2015-11-01

    Full Text Available Professor Andrzej Borowski from the Jagiellonian University, whose 70th anniversary we celebrate this year, is a very well known scholar and literature historian, specialised in Old Polish Literature (Middle Ages, Renaissance and Baroque - and with a background from Classical studies. A lesser known fact is that he also is a scholar active in the field of the Netherlandish (Dutch and Flemish literature and culture: as author of numerous books and articles about (South Netherlandish figures from the 16th and 17th century, as supervisor of numerous dissertations or habilitations in the field of the Netherlandish literature and as an inspiring personality in the field of the Netherlandish studies at Polish universities. He can indeed be seen as the Spiritus Litterarum Neerlandicorum in Poland.

  6. Daniel Kahneman, un psychologue en territoire économique

    OpenAIRE

    Frederic Teulon

    2014-01-01

    Daniel Kahneman est un psychologue et économiste américain, spécialiste de l’étude des comportements en situation d’incertitude. Il a conduit ses principaux travaux avec Amos Tversky. Il a reçu le prix Nobel d’économie 2002. Les deux articles fondateurs de Kahneman et Tversky (1974 et 1979) ont donné à la psychologie économique expérimentale ses lettres de noblesse.

  7. Commentary on Daniel Perttu's "A Quantitative Study of Chromaticism"

    Directory of Open Access Journals (Sweden)

    Art Samplaski

    2007-05-01

    Full Text Available The methodology used in Daniel Perttu’s article is analyzed for conformance to several criteria needed in quantitative studies. A number of problems are identified. Some of these appear to be deep structural issues given the nature of the question studied while others are caused by the methodology itself, by both the types of analyses carried out and the nature of the data source. Various suggestions to strengthen the study are made.

  8. Testing for Hardy-Weinberg proportions: have we lost the plot?

    National Research Council Canada - National Science Library

    Waples, Robin S

    2015-01-01

    Testing for Hardy-Weinberg proportions (HWP) is routine in almost all genetic studies of natural populations, but many researchers do not demonstrate a full understanding of the purposes of these tests or how to interpret the results...

  9. Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus.

    Science.gov (United States)

    Nielsen, D M; Ehm, M G; Weir, B S

    1998-01-01

    We review and extend a recent suggestion that fine-scale localization of a disease-susceptibility locus for a complex disease be done on the basis of deviations from Hardy-Weinberg equilibrium among affected individuals. This deviation is driven by linkage disequilibrium between disease and marker loci in the whole population and requires a heterogeneous genetic basis for the disease. A finding of marker-locus Hardy-Weinberg disequilibrium therefore implies disease heterogeneity and marker-disease linkage disequilibrium. Although a lack of departure of Hardy-Weinberg disequilibrium at marker loci implies that disease susceptibilityweighted linkage disequilibria are zero, given disease heterogeneity, it does not follow that the usual measures of linkage disequilibrium are zero. For disease-susceptibility loci with more than two alleles, therefore, care is needed in the drawing of inferences from marker Hardy-Weinberg disequilibria. PMID:9867708

  10. Bayesian methods for examining Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Wakefield, Jon

    2010-03-01

    Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the interpretation of the subsequent p-values, and choice of significance threshold depends critically on sample size, because equilibrium will always be rejected at conventional levels with large sample sizes. We argue for a Bayesian approach using both Bayes factors, and the examination of posterior distributions. We describe simple conjugate approaches, and methods based on importance sampling Monte Carlo. The former are convenient because they yield closed-form expressions for Bayes factors, which allow their application to a large number of single nucleotide polymorphisms (SNPs), in particular in genome-wide contexts. We also describe straightforward direct sampling methods for examining posterior distributions of parameters of interest. For large numbers of alleles at a locus we resort to Markov chain Monte Carlo. We discuss a number of possibilities for prior specification, and apply the suggested methods to a number of real datasets.

  11. A test of Hardy-Weinberg equilibrium in structured populations.

    Science.gov (United States)

    Sha, Qiuying; Zhang, Shuanglin

    2011-11-01

    Testing for Hardy-Weinberg equilibrium (HWE) is used routinely as an important initial step for genotype data quality checking. Departure from HWE can be caused by many factors, such as genotyping errors, population stratification, and disease association, if we use affected individuals only. In a structured population, even if a marker is in HWE in each subpopulation, data may show departure from HWE if allele frequencies are different in different subpopulations and such a departure can be misinterpreted as a potential problem in genotyping quality, resulting in false exclusion from future analysis. In this article, we propose a new HWE test, a test for HWE in structured populations (HWES) that can assess departure from HWE and take into account of population stratification at the same time. Our proposed test can distinguish departure from HWE caused by population stratification and departure from HWE caused by other factors. We use simulation studies as well as applications to real data sets to evaluate the performance of the proposed test. Results show that, for a wide range of population structures, our proposed test has correct type I error rates while the traditional χ(2) test will lead to false-positive results. In homogenous populations, our proposed test has comparable power with the traditional χ(2) test. © 2011 Wiley Periodicals, Inc.

  12. General relativistic tidal work for Papapetrou, Weinberg and Goldberg pseudotensors

    CERN Document Server

    So, Lau Loi

    2015-01-01

    In 1998 Thorne claimed that all pseudotensors give the same tidal work as the Newtonian theory. In 1999, Purdue used the Landau-Lifshitz pseudotensor to calculate the tidal heating and the result matched with the Newtonian gravity. Soon after in 2001, Favata employed the same method to examine the Einstein, Bergmann-Thomson and M{\\o}ller pseudotensors, all of them give the same result as Purdue did. Inspired by the work of Purdue and Favata, for the completeness, here we manipulate the tidal work for Papapetrou, Weinberg and Goldberg pseudotensors. We obtained the same tidal work as Purdue achieved. In addition, we emphasize that a suitable gravitational energy-momentum pseudotensor requires fulfill the inside matter condition and all of the classical pseudotensors pass this test except M$\\o$ller. Moreover, we constructed a general pseudotesnor which is modified by 13 linear artificial higher order terms combination with Einstein pseudotensor. We find that the result agrees with Thorne's prediction, i.e., rel...

  13. From the Weinberg Angle to Cardiac MRI a career change

    CERN Document Server

    ten Have, I.

    1997-01-01

    In summer 1994 I left particle physics to pursue a career in industry. Now three years later I am working for Philips Medical Systems in the Netherlands. I am responsible, both technically and commercially, for adapting the exist-ingMagnetic Resonance Imaging (MRI) technique for cardiology applications. In this seminar I will talk about the interesting challenges my current position holds for me. I will present the substantial added value of my working experience at CERN: the physics research, working at technological frontiers, the international collaboration, expatriate life. Finally I will also describe what I have done to actively support this career change. Speaker: 1985-1989 Ð University of Nijmegen and CERN - Ph.D. on B0-B0bar mixing, Eurojet, top quark cross-sections, test of the O(as3) QCD matrix element, calculations for future hadron colliders, UA1. 1989-1994 Ð University of Glasgow and CERN - ALEPH - Jet charge studies, measurement of the Weinberg Angle. 1994-1996 Ð Master of Business Administr...

  14. Professor Igor Yevseyev: In Memoriam Professor Igor Yevseyev: In Memoriam

    Science.gov (United States)

    2012-06-01

    Dear readers and authors, June 3, 2012 will mark five months since Professor Igor Yevseyev, Deputy Editor-in-Chief of both journals Laser Physics and Laser Physics Letters passed away, suddenly and unexpectedly. He was 67. Born in Moscow, he entered one of the world's best schools of physics, Moscow Engineering Physics Institute (MEPhI). With this renowned educational and research institution he bonded an alliance for his entire life, starting as an undergraduate student in the Department of Theoretical Physics and later continued as graduate student, assistant professor, associated professor, and full professor in the same department, a rare accomplishment of a person. All those years he retained the love of his life—the love for physics. He worked tirelessly as a teacher and scholar in this captivating field of knowledge. Professor Yevseyev was one of the founders of the international journal of Laser Physics in 1990, the first academic English language journal published in the former USSR. Later, in 2004, the second journal, Laser Physics Letters was brought to the forum of global laser physics community. The idea behind this new title was Professor Yevseyev's initiative to reach the readers and participants with new pioneering and break-through research results more rapidly. His leadership and indefatigable dedication to the quality of published materials made it possible that this journal reached international recognition in a few short years. Still, in order to attract even more attention of potential contributors and readers, Professor Yevseyev originally proposed to conduct the International Laser Physics Workshop (LPHYS) on the annual basis. Since 1992 the Workshop has been conducted every year, each year in a different country. As in all previous years, Professor Yevseyev was the key organizer of this year's workshop in Calgary, Canada. Sadly, this workshop will take place without him. Editorial Board

  15. The Profession and the Professors.

    Science.gov (United States)

    Dain, Phyllis

    1980-01-01

    Speculates on why graduate library schools have not, in the persons of their professors, produced theoretical leadership in Library Science. The ideals of professional ethical standards are contrasted with present practice. (RAA)

  16. Celdas electroquímicas: la pila Daniell.

    OpenAIRE

    Milla González, Miguel

    2013-01-01

    Se trata de un ejercicio interactivo en el que debe montarse la celda galvánica con los pares Cu(II)/Cu y Zn(II)/Zn. El montaje correcto da lugar a la pila de Daniell. Sin embargo, son posibles otras configuraciones en las que las semiceldas pueden incluso contener el mismo electrolito. En todos los casos, el potenciómetro mide el potencial del dispositivo montado y, en su caso, se muestra la reacción redox que tiene lugar en una de las semiceldas cuando se ponen en contacto directo oxidante ...

  17. Response to Professor Jean Guichard

    OpenAIRE

    Kargulowa, Alicja; Czerkawska, Alicja; Kłodkowska, Joanna; Siarkiewicz, Elżbieta; Zielińska-Pękał, Daria; Zierkiewicz, Edyta

    2013-01-01

    The article recounts a discussion inspired by Professor Jean Guichard’s letter to Professor Alicja Kargulowa. Its participants – a group of female counsellogists – are engaged in an e-mail exchange that freely unfolds in the symbolic space of the on-line discourse. Embedded in their own specific research, their contributions depart from a conventional, structured line of argumentation, spontaneously, and at the same time insightfully, reflecting on various facets of purification and translati...

  18. Quantification of the power of Hardy-Weinberg equilibrium testing to detect genotyping error.

    Science.gov (United States)

    Cox, David G; Kraft, Peter

    2006-01-01

    Deviation from Hardy-Weinberg equilibrium has become an accepted test for genotyping error. While it is generally considered that testing departures from Hardy-Weinberg equilibrium to detect genotyping error is not sensitive, little has been done to quantify this sensitivity. Therefore, we have examined various models of genotyping error, including error caused by neighboring SNPs that degrade the performance of genotyping assays. We then calculated the power of chi-square goodness-of-fit tests for deviation from Hardy-Weinberg equilibrium to detect such error. We have also examined the affects of neighboring SNPs on risk estimates in the setting of case-control association studies. We modeled the power of departure from Hardy-Weinberg equilibrium as a test to detect genotyping error and quantified the effect of genotyping error on disease risk estimates. Generally, genotyping error does not generate sufficient deviation from Hardy-Weinberg equilibrium to be detected. As expected, genotyping error due to neighboring SNPs attenuates risk estimates, often drastically. For the moment, the most widely accepted method of detecting genotyping error is to confirm genotypes by sequencing and/or genotyping via a separate method. While these methods are fairly reliable, they are also costly and time consuming.

  19. Statistical inference for Hardy-Weinberg proportions in the presence of missing genotype information.

    Science.gov (United States)

    Graffelman, Jan; Sánchez, Milagros; Cook, Samantha; Moreno, Victor

    2013-01-01

    In genetic association studies, tests for Hardy-Weinberg proportions are often employed as a quality control checking procedure. Missing genotypes are typically discarded prior to testing. In this paper we show that inference for Hardy-Weinberg proportions can be biased when missing values are discarded. We propose to use multiple imputation of missing values in order to improve inference for Hardy-Weinberg proportions. For imputation we employ a multinomial logit model that uses information from allele intensities and/or neighbouring markers. Analysis of an empirical data set of single nucleotide polymorphisms possibly related to colon cancer reveals that missing genotypes are not missing completely at random. Deviation from Hardy-Weinberg proportions is mostly due to a lack of heterozygotes. Inbreeding coefficients estimated by multiple imputation of the missings are typically lowered with respect to inbreeding coefficients estimated by discarding the missings. Accounting for missings by multiple imputation qualitatively changed the results of 10 to 17% of the statistical tests performed. Estimates of inbreeding coefficients obtained by multiple imputation showed high correlation with estimates obtained by single imputation using an external reference panel. Our conclusion is that imputation of missing data leads to improved statistical inference for Hardy-Weinberg proportions.

  20. Understanding Of Wisdom In The Book Of Daniel

    Directory of Open Access Journals (Sweden)

    Peniel C.D. Maiaweng

    2016-03-01

    Full Text Available Daniel, Hananiah, Misael, and Azariah were young Jewish people who had been taken to Babylon in captivity. They truly obeyed God in their daily life and did not defile themselves with the king’s food and wine. God honored their decision so He gave them wisdom, that is intellectual ability (knowledge and understanding of all kinds of literature and learning and understanding visions and dreams of all kinds. Their response to the wisdom from God was having a good life style, submitting to God, and carrying burdens. To continue the wisdom from God, they lived in unity, depended on God and had God’s spirit in them. In doing their job, they spoke with wisdom and tact and worked honestly. In working with the king, they made a courageous decision not to worship the image of god and not to follow the king’s command. In the king’s palace, Daniel did not think for himself only, but had a burden to pray for Jerusalem, represent his nation before God, and fast for the future. 

  1. Euroopa tulevikuvisiooni näeme Ceutas ja Melillas / Daniel Pipes ; intervjueerinud Taavi Minnik

    Index Scriptorium Estoniae

    Pipes, Daniel

    2016-01-01

    Intervjuu Lähis-Ida Foorumi presidendi Daniel Pipesiga Euroopa migratsioonikriisist ja vigadest migratsioonipoliitikas. Probleemidest, mida massiimmigratsioon Kolmandast Maailmast Euroopale kaasa toob ning radikaalse islami ohtudest

  2. Is the Higgs boson associated with Coleman-Weinberg dynamical symmetry breaking?

    Energy Technology Data Exchange (ETDEWEB)

    Hill, Christopher T. [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2014-04-01

    The Higgs mechanism may be a quantum phenomenon, i.e., a Coleman-Weinberg potential generated by the explicit breaking of scale symmetry in Feynman loops. We review the relationship of scale symmetry, trace anomalies, and emphasize the role of the renormalization group in determining Coleman- Weinberg potentials. We propose a simple phenomenological model with "maximal visibility" at the LHC containing a "dormant" Higgs doublet (no VEV, coupled to standard model gauge interactions $SU(2)\\times U(1)$) with a mass of $\\sim 380$ GeV. We discuss the LHC phenomenology and UV challenges of such a model. We also give a schematic model in which new heavy fermions, with masses $\\sim 230$ GeV, can drive a Coleman-Weinberg potential at two-loops. The role of the "improved stress tensor" is emphasized, and we propose a non-gravitational term, analogous to the $\\theta$-term in QCD, which generates it from a scalar action.

  3. A test of homogeneity of Hardy-Weinberg disequilibrium across strata.

    Science.gov (United States)

    Yin, Xiao-Lin; Ma, Wen-Qing; Tang, Man-Lai; Guo, Jianhua

    2006-11-01

    For genotype data being sampled from several strata with different allele frequencies, it is necessary to verify the assumption of homogeneity of Hardy-Weinberg disequilibrium across strata before testing Hardy-Weinberg law across strata. In practice, disequilibrium can be measured via fixation coefficients (ie, ratios of genotypic frequencies) or disequilibrium coefficients (ie, differences of genotypic frequencies). Test for homogeneity of Hardy-Weinberg disequilibrium using data from several populations has been derived according to fixation coefficients. In this article, using the likelihood score theory extended to nuisance parameters, we derive a homogeneity score test for comparing disequilibrium coefficients across several independent strata. Simulation results demonstrate that the homogeneity score test performs satisfactorily in the sense that its empirical size seldom exceeds the pre-chosen nominal level by more than 10% even for small sample sizes. Corresponding power and sample size formulae are provided as well. We illustrate our test with a real glyoxalase genotype data set.

  4. El ensayo, un estilo de pensar y decir: Entrevista a Liliana Weinberg

    Directory of Open Access Journals (Sweden)

    Eduardo César Maia

    2014-12-01

    Full Text Available [ES] En esta entrevista Liliana Weinberg aborda los orígenes del ensayo —inaugurado por Michel de Montaigne —, las principales características de esta «prosa de ideas» y su producción en el mundo actual. [EN] In this interview Liliana Weinberg discusses the origins of the essay —initiated by Michel de Montaigne—, the main characteristics of this "prose of ideas", and its production in the world today.

  5. A POWERFUL METHOD FOR INCLUDING GENOTYPE UNCERTAINTY IN TESTS OF HARDY-WEINBERG EQUILIBRIUM.

    Science.gov (United States)

    Beck, Andrew; Luedtke, Alexander; Liu, Keli; Tintle, Nathan

    2017-01-01

    The use of posterior probabilities to summarize genotype uncertainty is pervasive across genotype, sequencing and imputation platforms. Prior work in many contexts has shown the utility of incorporating genotype uncertainty (posterior probabilities) in downstream statistical tests. Typical approaches to incorporating genotype uncertainty when testing Hardy-Weinberg equilibrium tend to lack calibration in the type I error rate, especially as genotype uncertainty increases. We propose a new approach in the spirit of genomic control that properly calibrates the type I error rate, while yielding improved power to detect deviations from Hardy-Weinberg Equilibrium. We demonstrate the improved performance of our method on both simulated and real genotypes.

  6. Daniel Link, Suturas. Imágenes, escritura, vida

    Directory of Open Access Journals (Sweden)

    Lucia Faienza

    2015-11-01

    Full Text Available Ultimo di una trilogia saggistica preceduto da Clases (2005 e Fantasmas (2009, Suturas (2015 chiude il cerchio di quella che il suo autore, Daniel Link, chiama «interrogación sobre lo viviente». Già il titolo mostra l’ambiguità da cui prende avvio la riflessione di Link e che attraversa la pluralità degli oggetti su cui si posa lo sguardo dell’autore: la ”sutura” è tanto la cucitura che unisce la vecchia cultura letteraria con le nuove culture digitali e post-letterarie, quanto la cicatrice che marca la “ferita” di questo cambio di paradigma dentro al corpo della contemporaneità.

  7. Daniel Compère, Les Romans populaires

    OpenAIRE

    Del Giudice, Eloisa

    2016-01-01

    Arsène Lupin, Rouletabille, le Comte de Monte-Cristo mais aussi Maigret ou Rocambole, les personnages des romans populaires d’hier à aujourd’hui ont fasciné des légions de lecteurs. Daniel Compère, spécialiste du sujet, y consacre une étude pointue. Pour bien commencer, il faut dans un premier chapitre donner une définition de ce qu’est le roman populaire. Mais cette tâche est ardue. Phénomène littéraire né au XIXe siècle, c’est un très vaste domaine : romans de cape et d’épée, à l’eau de ros...

  8. The indigenous ethos in the literary memoirs of Daniel Munduruku

    Directory of Open Access Journals (Sweden)

    Waniamara de Jesus dos Santos

    2013-10-01

    Full Text Available Adopting the theories postulated by Classical Rhetoric and Argumentation Discourse, this paper comes up with a reflection about the identity built by Daniel Munduruku in his memories ‘Meu vô Apolinário: um mergulho no rio da (minha memória’ The indigenous writer assumes the world of classical rhetorical tradition and expose his ideas in order to change preconceived concepts about the visibility of indigenous people by non-indigenous brazilian society. Munduruku shows a new indigenous appearence resulting from the performance between previosly and shown ethos, working both: his ‘fame’ and a new person built in his book and captured by the reader. Adopting gender epidictic, the construction of the indigenous ethos is done in a apparently harmless way, lying hidden the purpose to recreate new values about the world’s indigenous peoples in Brazil.

  9. Il professor Mitja Skubic ottuagenario

    Directory of Open Access Journals (Sweden)

    Martina Ožbot

    2008-12-01

    Full Text Available Incredibile ma vero: il professor Mitja Skubic si trova, questa volta lui stesso, al centro dell’attenzione anziché essere il motore, il perno dell’attività. La ragione per questo attimo di respiro è il suo ottantesimo compleanno, a dire il vero passato già da tempo. È pressoché una contingenza aneddotica quella per cui il volume dedicatogli per l’occasione viene pubblicato così tardi: il professore ha continuato a tener d’occhio la nostra rivista ben dopo aver nominato i nuovi direttori tanto che sarebbe stato impossibile sorprenderlo con una miscellanea di contributi in suo onore.

  10. Professor@s e Eros Teachers and Eros

    Directory of Open Access Journals (Sweden)

    Deborah P. Britzman

    2009-01-01

    Full Text Available Professores/as são testemunhas do fantástico mundo da sexualidade. Esse artigo explora a centralidade de Eros para a educação e estabelece uma relação entre o desejo do/a professor/a e os acontecimentos emocionais da relação própria relação aluno/professor. Eu proponho que o aprendizado deva envolver nosso "eu" erótico, além das nossas fantasias. Mas esta perspectiva requer que professores/as considerem uma psicologia do amor como um caminho principal para a as situações emocionais de Eros. Na sua conclusão este trabalho sugere uma pedagogia que dê as boas vindas tanto à homossexualidade como a heterossexualidade como expressões humanas do amor.Teachers bear witness to the wondrous world of sexuality. This essay explores the centrality of Eros to education and links the teacher's desire to the emotional situation of the student/teacher relationship. I propose that learning involves our erotic selves and our fantasy life. But such a view requires that teachers consider a psychology of love as lending insight into the emotional situation of Eros. The paper concludes by suggesting a pedagogy that welcomes homosexuality and heterosexuality as human expressions of love.

  11. El testamento y otros documentos sobre Daniele da Volterra

    Directory of Open Access Journals (Sweden)

    Redín, Gonzalo

    2010-09-01

    Full Text Available Daniele da Volterra is better known in Spain for painting the drapery that covers some of the nudes in Michelangelo’s The Last Judgment than for his own work, which defined him as his master’s most loyal successor. Nonetheless, Daniele’s influence on Spanish art through Gaspar Becerra, a disciple of his in Rome, determined to a large extent the development of sculpture in this country in the second half of the 16th century. This article makes known and discusses Daniele’s previously unpublished last will and testament, located in the Archivio di Stato di Roma among the volumes by the notary Thomassino, who attended to the inventory of his possessions. It also provides new details on Daniele’s estate and on his direct disciples Michele Alberti, Feliciano de San Vito, and Biagio Betti along with his indirect ones such as Jacopo Rocchetti.

    Daniele da Volterra es más conocido en España por pintar los paños que cubren algunos de los desnudos del Juicio final de Miguel Ángel, que por su obra, que le define como el más fiel heredero de su maestro. Sin embargo, su influencia en el arte español a través de Gaspar Becerra, discípulo suyo en Roma, condicionó el desarrollo de la escultura en buena parte de nuestro país en la segunda mitad del siglo XVI. Publicamos y comentamos aquí su testamento inédito, localizado en el Archivio di Stato di Roma entre los volúmenes del notario Thomassino, que se encargó del inventario de sus bienes, y aportamos noticias relativas a su herencia y a sus discípulos directos, Michele Alberti, Feliciano de San Vito y Biagio Betti, e indirectos, como Jacopo Rocchetti.

  12. Reflection on the "New Dynamics" of Distance Education: An Interview with Sir John Daniel

    Science.gov (United States)

    Latchem, Colin

    2012-01-01

    This article presents an interview with Sir John Daniel outgoing President and CEO of the Commonwealth of Learning. Sir John Daniel's term as President and Chief Executive Officer of the Commonwealth of Learning (COL) ended on May 31, 2012. Readers of "Distance Education" will know of Sir John's work at the Tele-universite (Directeur des…

  13. Daniel 6: There and back again – A deity's tale | de Bruyn | HTS ...

    African Journals Online (AJOL)

    This article states that, with his narrative, the author of Daniel 6 creates the presence of Elohim outside Jerusalem and Israel, within non-Israelite environments. Applying a body-space frameset to the texts of Daniel 6 helps to read the text as a construction of concepts. With his narrative the author creates the presence of ...

  14. 77 FR 75819 - Death of Senator Daniel K. Inouye, President Pro Tempore of the Senate

    Science.gov (United States)

    2012-12-21

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 77 Friday, No. 246 December 21, 2012 Part VI The President Proclamation 8919--Death of Senator Daniel K. Inouye, President Pro... ] Proclamation 8919 of December 18, 2012 Death of Senator Daniel K. Inouye, President Pro Tempore of the Senate...

  15. The function of poetic speech in the narrative in Daniel 2 | Venter ...

    African Journals Online (AJOL)

    Two poetic sections are identified and investigated in Daniel 2. Attention is paid to the function of these poems within the narrative in Daniel 2 and its particular structure. The conclusion is drawn that poetic speech is used here as a focusing technique to point out the main themes of the narrative.

  16. Significant deviations from Hardy-Weinberg equilibrium caused by low levels of microsatellite genotyping errors.

    Science.gov (United States)

    Morin, Phillip A; Leduc, Richard G; Archer, Frederick I; Martien, Karen K; Huebinger, Ryan; Bickham, John W; Taylor, Barbara L

    2009-03-01

    Microsatellite genotyping from samples with varying quality can result in an uneven distribution of errors. Previous studies reporting error rates have focused on estimating the effects of both randomly distributed and locus-specific errors. Sample-specific errors, however, can also significantly affect results in population studies despite a large sample size. From two studies including six microsatellite markers genotyped from 272 sperm whale DNA samples, and 33 microsatellites genotyped from 213 bowhead whales, we investigated the effects of sample- and locus-specific errors on calculations of Hardy-Weinberg equilibrium. The results of a jackknife analysis in these two studies identified seven individuals that were highly influential on estimates of Hardy-Weinberg equilibrium for six different markers. In each case, the influential individual was homozygous for a rare allele. Our results demonstrate that Hardy-Weinberg P values are very sensitive to homozygosity in rare alleles for single individuals, and that > 50% of these cases involved genotype errors likely due to low sample quality. This raises the possibility that even small, normal levels of laboratory errors can result in an overestimate of the degree to which markers are out of Hardy-Weinberg equilibrium and hence overestimate population structure. To avoid such bias, we recommend routine identification of influential individuals and multiple replications of those samples. © 2009 Blackwell Publishing Ltd. No claim to original US government works.

  17. Environmental Medicine Genome Bank (EMGB): Hardy-Weinberg Equilibrium at an Eotaxin Locus on Chromosome 17

    National Research Council Canada - National Science Library

    Dikeidek, Murad

    2002-01-01

    ...), we determined the eotaxin ALA23-THR23 genotypes of 233 samples in the EMGB. The observed allele frequencies were then used to determine the distribution of genotypes that would be expected from the assumptions of the Hardy-Weinberg equilibrium...

  18. Mass generation for gauge fields in the Salam-Weinberg theory without Higgs

    OpenAIRE

    Barcelos-Neto, J.; Rabello, S.

    1996-01-01

    We consider the Salam-Weinberg theory by introducing tensor gauge fields. When these fields are coupled in a topological way with the vector ones, the resulting system constitutes an alternative mechanism of mass generation for vector fields without the presence of Higgs bosons. We show that these masses are in agreement with the ones obtained by means of the spontaneous symmetry breaking.

  19. The universal eigenvalue bounds of Payne–Pólya–Weinberger, Hile ...

    Indian Academy of Sciences (India)

    In this paper we present a unified and simplified approach to the universal eigenvalue inequalities of Payne–Pólya–Weinberger, Hile–Protter, and Yang. We then generalize these results to inhomogeneous membranes and Schrödinger's equation with a nonnegative potential. We also show that Yang's inequality is always ...

  20. Weinberg Angle Derivation from Discrete Subgroups of SU(2 and All That

    Directory of Open Access Journals (Sweden)

    Potter F.

    2015-01-01

    Full Text Available The Weinberg angle W of the Standard Model of leptons and quarks is derived from specific discrete (i.e., finite subgroups of the electroweak local gauge group SU(2 L U(1 Y . In addition, the cancellation of the triangle anomaly is achieved even when there are four quark families and three lepton families!

  1. Professors of the New Economy.

    Science.gov (United States)

    Wilson, Robin

    2000-01-01

    Profiles four professors who epitomize the increasing influence of academe on new technology-driven Internet business: a start-up maven, Steven Kaplan; a social psychologist, Michael Ray; a cyberlawyer, David Post; and an e-commerce expert, Andrew B. Whinston. (DB)

  2. NOTES ON CONTRIBUTORS H. Johnson Nenty, Professor ...

    African Journals Online (AJOL)

    Admin

    NOTES ON CONTRIBUTORS. H. Johnson Nenty, Professor, Educational Research, Measurement and Evaluation, Department of Educational. Foundations, University of Botswana Idowu Biao, Professor of Lifelong learning, Department of Adult Education,. University of Botswana. Cletus K. Mbowura, Lecturer, Department of ...

  3. ICT Use by Journalism Professors in Colombia

    Science.gov (United States)

    Hung, Elias Said

    2011-01-01

    This article analyses how journalism professors at Colombian universities use information and communications technologies (ICT) in their teaching. Survey data was obtained during the first trimester of 2009 from 63 professors in journalism departments and from a total of 865 professors who are affiliated with journalism departments at 29…

  4. Erratum: Professor J. H. S. Gear

    African Journals Online (AJOL)

    s short of their. Lesley, a nd their amily a proper Wake on 15 November 1994. Erratum: Professor J. H. S. Gear. The name of Professor B. D. Schoub, Director of the. National Institute for Virology, was inadvertently omitted as the author of the obituary of Professor J. H. S. Gear published in the September 1994 SAMJ. Books.

  5. Memorial Meeting for Nobel Laureate Professor Abdus Salam's 90th Birthday

    CERN Document Server

    2016-01-01

    Abdus Salam was one of the most prolific and exciting scientists of the second half of the last century. From humble beginnings in a village in Pakistan, he rose to become one of the world's most original and influential particle physicists. He shared the 1979 Nobel Prize with Glashow and Weinberg for contributions to electroweak unification, which forms an integral part of the Standard Model. He was the first Pakistani Nobel Laureate and the second only Muslim after Anwar Sadat. After gaining his doctorate in Cambridge, he moved to Imperial College in 1957 where he founded the very successful Theoretical High Energy Physics Group. He remained there as Professor of Physics until his death in 1996.

  6. Daniel 6: There and back again – A deity’s tale

    Directory of Open Access Journals (Sweden)

    Joseph J. de Bruyn

    2015-03-01

    Full Text Available This article states that, with his narrative, the author of Daniel 6 creates the presence of Elohim outside Jerusalem and Israel, within non-Israelite environments. Applying a body-space frameset to the texts of Daniel 6 helps to read the text as a construction of concepts. With his narrative the author creates the presence of Elohim outside Jerusalem and Israel, within non-Israelite environments. Furthermore, a spatial frameset shows that the story of Daniel 6 can be read as a conclusion to a larger narrative that stretches from Daniel 1–6. In this narrative the author utilises spatial concepts such as the character of Daniel; the lion’s den; Jerusalem and King Darius, to establish the omnipresence of the God of Israel. In constructing this presence of-God reality the author conveys a message of hope and trust in the authority of the God of Israel. In this regard Daniel 6 is not just a story about the character Daniel being persecuted for his faith; rather it is a story about the God of Israel establishing his presence and his ability to act through and within space and time.

  7. Book reviews: Daniel Kahneman - Thinking, Fast and Slow

    Directory of Open Access Journals (Sweden)

    Cristian Uta

    2016-09-01

    Full Text Available Although he has won the Nobel Prize for Economy (for his works on the decision theory, Daniel Kahneman is, surprisingly, a psychologist. Thinking, Fast and Slow presents us ideas and theories regarding the way in which the mind works and how this thing affects us when making a decision. In his opinion, the human thinking is a dual process, duality presented from three different perspec-tives. First (as the title suggests it, there are highlighted the differences between the fast and the slow thinking. Then the distinction between econs (rational agents of the classical economic theory and of the importance of economic schools of Chicago and humans (real people, which are not irrational but to whom the rational model does not fit is argued. Finally, the author presents us the conflicts between the remembering self and the experiencing self in respect to the way in which these selves perceive the wellbeing.   The volume contains 38 chapters structured in five parts. At the end, there is a Conclusions section and there are attached two articles written by Kahneman together with his friend Amos Tversky which present the contributions that have been cited by the Nobel committee for justifying the award given in 2002 (Tversky died in 1996 and he could not be awarded the Nobel Prize, although he would have deserved it.

  8. Apuntes sobre el 'teatro civile'. Entrevista a Daniele Biacchessi

    Directory of Open Access Journals (Sweden)

    Daniele Biacchessi

    2016-01-01

    Full Text Available Unas pocas líneas no bastan para presentar la figura del periodista, escritor y dramaturgo Daniele Biacchessi. Su amplia labor como periodista en algunos de los medios de difusión más relevantes de Italia y su constante producción como divulgador y creador  del llamado teatro civil hacen de él una figura que no puede dejarse de lado a la hora de hablar del teatro de inspiración cívica de la última década. Interesado en denunciar desde desastres medioambientales como en La fabbrica dei profumi o las matanzas nazis en Sant'Anna di Stazzema y Marzabotto a finales de la Segunda Guerra Mundial, basta dar un vistazo a algunos de sus títulos para tener una idea de la amplitud de temas tratados por Biacchessi, entre los que destacan Giovanni e Nori. Una storia di amore e di resistenza (2014, Passione reporter (2009, Il paese della vergogna (2007, Una stella a cinque punte. Le inchieste D'Antona e Biagi e le nuove Br (2007. Completan la entrevista hecha por Massimiliano Vellini dos pequeños fragmentos de uno de los manuales fundamentales sobre el llamado teatro de carácter cívico, Teatro civile, nei luoghi dell'inchiesta e della narrazione (Milán: Edizioni Ambiente, 2010.

  9. Remarks from Congressional Leaders: Congressman Daniel Lipinski (2011 EFRC Summit)

    Energy Technology Data Exchange (ETDEWEB)

    Lipinski, Daniel

    2011-05-25

    Congressman Daniel Lipinski (D-Illinois) spoke during the opening session of the EFRC Summit. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  10. Straight talk with...Daniel Levy. Interviewed by Elie Dolgin.

    Science.gov (United States)

    Levy, Daniel

    2013-10-01

    The Framingham Heart Study (FHS) has long been a beacon of biomedical research, yielding landmark findings on everything from the links between elevated blood pressure and stroke to the genetic risk factors underlying cardiac arrhythmias. Now, the fabled 65-year-long study of cardiovascular disease is the beacon of a more modern trend in science: tight budgets. Thanks to the automatic cuts in US government spending known as sequestration, the approximately $9-million-per-year contract the FHS receives from the US National Heart, Lung, and Blood Institute (NHLBI) was reduced by $4 million on 1 August. The renewal of the contract, scheduled for 2015, is expected to run for only two or three years, instead of the usual seven as it has been in the past. And next month, the most visible effects of the cuts will take hold, when 19 layoffs (out of a total of 90 total staff members) go into effect. Overseeing the budget-related turbulence is Daniel Levy, a medical officer at the NHLBI who joined the FHS nearly 30 years ago and has served as the study's director since 1994. Elie Dolgin met with Levy in Framingham, on the outskirts of Boston, to discuss how he's taking the new funding realities to heart.

  11. Daniel Goodman’s empirical approach to Bayesian statistics

    Science.gov (United States)

    Gerrodette, Tim; Ward, Eric; Taylor, Rebecca L.; Schwarz, Lisa K.; Eguchi, Tomoharu; Wade, Paul; Himes Boor, Gina

    2016-01-01

    Bayesian statistics, in contrast to classical statistics, uses probability to represent uncertainty about the state of knowledge. Bayesian statistics has often been associated with the idea that knowledge is subjective and that a probability distribution represents a personal degree of belief. Dr. Daniel Goodman considered this viewpoint problematic for issues of public policy. He sought to ground his Bayesian approach in data, and advocated the construction of a prior as an empirical histogram of “similar” cases. In this way, the posterior distribution that results from a Bayesian analysis combined comparable previous data with case-specific current data, using Bayes’ formula. Goodman championed such a data-based approach, but he acknowledged that it was difficult in practice. If based on a true representation of our knowledge and uncertainty, Goodman argued that risk assessment and decision-making could be an exact science, despite the uncertainties. In his view, Bayesian statistics is a critical component of this science because a Bayesian analysis produces the probabilities of future outcomes. Indeed, Goodman maintained that the Bayesian machinery, following the rules of conditional probability, offered the best legitimate inference from available data. We give an example of an informative prior in a recent study of Steller sea lion spatial use patterns in Alaska.

  12. Pseudo-Random Mating Populations. in Celebration of the 80th Anniversary of the Hardy-Weinberg Law

    OpenAIRE

    Li, C. C.

    1988-01-01

    That random mating leads to Hardy-Weinberg distribution of genotypes is well known. This report is to show that, if the deviations from random mating are of a certain pattern, the offspring generation will also be in Hardy-Weinberg proportions. This brings out the fact that random mating is a sufficient condition, not a necessary one, for the attainment of the Hardy-Weinberg proportions. Such nonrandom-mating populations are tentatively said to be pseudo-random mating. Pseudo-random-mating po...

  13. A likelihood ratio test of population Hardy-Weinberg equilibrium for case-control studies.

    Science.gov (United States)

    Yu, Chang; Zhang, Sanguo; Zhou, Chuan; Sile, Saba

    2009-04-01

    Testing Hardy-Weinberg equilibrium (HWE) in the control group is commonly used to detect genotyping errors in genetic association studies. We propose a likelihood ratio test for testing HWE in the study population using both case and control samples. This test incorporates underlying association models. Another feature is that, when we infer the disease-genotype association, we explicitly incorporate HWE or a possible departure from Hardy-Weinberg equilibrium (DHWE) into the model. Our unified framework enables us to infer the disease-genotype association when a detected DHWE needs to be part of the model after causes for the DHWE are explored. Real data sets are used to illustrate the application of the methodology and its implication in genetic association studies. Our analysis and interpretation touch on issues such as genotyping errors, population selection, population stratification, or the study sampling plan, that all could be the cause of DHWE.

  14. Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Zintzaras, Elias

    2008-01-01

    In gene-disease association studies, deviation from Hardy-Weinberg equilibrium in controls may cause bias in estimating the allele-based estimates of genetic effects. An approach to adjust the variance of allele-based odds ratio for Hardy-Weinberg equilibrium deviation is proposed. Such adjustments have been introduced for estimating relative risks of genotype contrasts and differences in allele frequency; however, an adjustment of odds ratios for allele frequencies still does not exist. The approach was based on the delta method in combination with the Woolf's logit interval method and the disequilibrium coefficient. The proposed variance adjustment provided better power than the unadjusted one to detect significant estimates of odds ratio and it improved the variance estimation.

  15. Does 5HTTLPR long allele prevent hospitalization? Test of Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Shinozaki, Gen; Kung, Simon; Mrazek, David A

    2014-02-01

    Many studies suggest an association of the serotonin transporter gene polymorphism (5HTTLPR) long allele with better antidepressant treatment response than the short allele. However, there is controversy over these findings. We hypothesized that if the long allele is associated with a better outcome, we would find fewer inpatients with the long allele compared with the short allele. Chart review identified 925 depressed inpatients and 201 outpatients genotyped for 5HTTLPR. The sample was primarily White (>90%). We tested potential departures from Hardy-Weinberg equilibrium for each sample. We analyzed three independent sets of inpatient samples separately and combined, a White subgroup of 791 patients of the total 925 inpatients, and 201 outpatients. There was no departure from Hardy-Weinberg equilibrium with any of these samples. We also compared 5HTTLPR genotype prevalence between 925 inpatients and 201 outpatients, which showed no statistically significant difference.

  16. Presidential Green Chemistry Challenge: 2005 Greener Synthetic Pathways Award (Archer Daniels Midland Company/Novozymes)

    Science.gov (United States)

    Presidential Green Chemistry Challenge 2005 award winners, Archer Daniels Midland (ADM) and Novozymes, developed an enzymatic interesterification process to make edible fats and oils containing low trans fatty acids and oils.

  17. Business leadership concepts exemplified by the two exceptional leaders Daniel Vasella and Ricardo Semler

    NARCIS (Netherlands)

    Patrick Szillat; Alexander Betov

    2016-01-01

    Purpose – Against the background of current leadership theory, this research paper analyses and compares the leadership approaches of two outstanding leaders: Daniel Vasella, chairman of the leading Swiss pharmaceutical organization Novartis and Ricardo Semler, owner of the Brazilian conglomerate

  18. Exact significance levels of goodness-of-fit tests for the Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Haber, M

    1981-01-01

    The aim of this work is to examine the validity of several chi2 criteria, when used to test the fit of genotypic frequencies to the Hardy-Weinberg law. The exact type I error probabilities were compared to the nominal significance levels for two genetic models. The Pearson's chi2 test usually provided the best approximations. This test was found to be remarkably robust, when in situations involving very small expected frequencies.

  19. A straightforward multiallelic significance test for the Hardy-Weinberg equilibrium law

    OpenAIRE

    Lauretto,Marcelo S.; Fabio Nakano; FARIA JR, Silvio R.; PEREIRA, CARLOS A. de B.; Stern,Julio M.

    2009-01-01

    Much forensic inference based upon DNA evidence is made assuming Hardy-Weinberg Equilibrium (HWE) for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, and their limitations become more obvious when testing for deviation within multiallelic DNA loci. The most popular methods-Chi-square and Likelihood-ratio tests-are based on asymptotic results and cannot guarantee a good performance in the presence of low frequency genotypes. Si...

  20. A note on testing the Hardy-Weinberg law across strata.

    Science.gov (United States)

    Troendle, J F; Yu, K F

    1994-10-01

    The problem of testing the Hardy-Weinberg law when the data are stratified in K strata is considered. Previous methods lose power when the departure from the law is irregular from stratum to stratum. Two methods based on the squared distance are proposed to overcome this problem. Simulations show that the new methods can have a dramatic improvement over the previous methods. The methods are applied to red cell glyoxalase genotype data from populations in India.

  1. Taking up Daniels' challenge: The case for global health justice.

    Science.gov (United States)

    Ooms, Gorik; Hammonds, Rachel

    2010-06-15

    In "Just Health", Norman Daniels makes a strong argument for obligations of mutual assistance to fulfill the right to health at the national level and challenges readers to develop arguments supporting obligations of mutual assistance at the global level. In this paper, we argue that there is global responsibility for global health and that there are obligations of justice (beyond charity) to help fulfill (not merely respect or even protect) the right to health in other countries; these we call obligations of global health justice. We show how international human rights law affirms obligations of global health justice - beyond national obligations and beyond obligations of charity - and assert that the human rights approach provides guidance on delineating the relationship between national and global responsibility for fulfilling the core obligations that arise from socioeconomic human rights and addressing global health inequities. We further argue that new ways of providing international assistance, originating from the global HIV/AIDS response, demonstrate the feasibility of improving health outcomes through exogenous efforts and that obligations of global health justice thus carry much weight: the weight of lives not saved. The global response to the HIV/AIDS pandemic has led to the emergence of a new international health assistance paradigm, and the Global Fund to fight AIDS, Tuberculosis and Malaria is, we suggest, an embryonic form of this new paradigm. We conclude that agreements on several common parameters delineating global and national responsibility for global health can advance the movement towards a global institution for the distribution of health-related goods.

  2. A Bayesian test for Hardy-Weinberg equilibrium of biallelic X-chromosomal markers.

    Science.gov (United States)

    Puig, X; Ginebra, J; Graffelman, J

    2017-10-01

    The X chromosome is a relatively large chromosome, harboring a lot of genetic information. Much of the statistical analysis of X-chromosomal information is complicated by the fact that males only have one copy. Recently, frequentist statistical tests for Hardy-Weinberg equilibrium have been proposed specifically for dealing with markers on the X chromosome. Bayesian test procedures for Hardy-Weinberg equilibrium for the autosomes have been described, but Bayesian work on the X chromosome in this context is lacking. This paper gives the first Bayesian approach for testing Hardy-Weinberg equilibrium with biallelic markers at the X chromosome. Marginal and joint posterior distributions for the inbreeding coefficient in females and the male to female allele frequency ratio are computed, and used for statistical inference. The paper gives a detailed account of the proposed Bayesian test, and illustrates it with data from the 1000 Genomes project. In that implementation, a novel approach to tackle multiple testing from a Bayesian perspective through posterior predictive checks is used.

  3. Deviations from Hardy-Weinberg proportions for multiple alleles under viability selection.

    Science.gov (United States)

    Alvarez, Gonzalo

    2008-04-01

    Departures of genotype frequencies from Hardy-Weinberg proportions (HWP) for a single autosomal locus due to viability selection in a random mating population have been studied only for the two-allele case. In this article, the analysis of deviations from HWP due to constant viability selection is extended to multiple alleles. The deviations for an autosomal locus with k alleles are measured by means of k fii fixation indices for homozygotes and k(k-1)/2 fij fixation indices for heterozygotes, and expressions are obtained for these indices (FIS statistics) under the multiallele viability model. Furthermore, expressions for fii and fij when the multiallele polymorphism is at stable equilibrium are also derived and it is demonstrated that the pattern of multiallele Hardy-Weinberg deviations at equilibrium is characterized by a global heterozygote excess and a deficiency of each of the homozygotes. This pattern may be useful for detecting whether a given multiallelic polymorphism is at stable equilibrium in the population due to viability selection. An analysis of Hardy-Weinberg deviations from published data for the three-allele polymorphism at the beta-globin locus in human populations from West Africa is presented for illustration.

  4. Exact Inference for Hardy-Weinberg Proportions with Missing Genotypes: Single and Multiple Imputation.

    Science.gov (United States)

    Graffelman, Jan; Nelson, S; Gogarten, S M; Weir, B S

    2015-09-15

    This paper addresses the issue of exact-test based statistical inference for Hardy-Weinberg equilibrium in the presence of missing genotype data. Missing genotypes often are discarded when markers are tested for Hardy-Weinberg equilibrium, which can lead to bias in the statistical inference about equilibrium. Single and multiple imputation can improve inference on equilibrium. We develop tests for equilibrium in the presence of missingness by using both inbreeding coefficients (or, equivalently, χ(2) statistics) and exact p-values. The analysis of a set of markers with a high missing rate from the GENEVA project on prematurity shows that exact inference on equilibrium can be altered considerably when missingness is taken into account. For markers with a high missing rate (>5%), we found that both single and multiple imputation tend to diminish evidence for Hardy-Weinberg disequilibrium. Depending on the imputation method used, 6-13% of the test results changed qualitatively at the 5% level. Copyright © 2015 Graffelman et al.

  5. A Hardy-Weinberg equilibrium test for analyzing population genetic surveys with complex sample designs.

    Science.gov (United States)

    Moonesinghe, Ramal; Yesupriya, Ajay; Chang, Man-Huei; Dowling, Nicole F; Khoury, Muin J; Scott, Alastair J

    2010-04-15

    Testing for deviations from Hardy-Weinberg equilibrium is a widely recommended practice for population-based genetic association studies. However, current methods for this test assume a simple random sample and may not be appropriate for sample surveys with complex survey designs. In this paper, the authors present a test for Hardy-Weinberg equilibrium that adjusts for the sample weights and correlation of data collected in complex surveys. The authors perform this test by using a simple adjustment to procedures developed to analyze data from complex survey designs available within the SAS statistical software package (SAS Institute, Inc., Cary, North Carolina). Using 90 genetic markers from the Third National Health and Nutrition Examination Survey, the authors found that survey-adjusted and -unadjusted estimates of the disequilibrium coefficient were generally similar within self-reported races/ethnicities. However, estimates of the variance of the disequilibrium coefficient were significantly different between the 2 methods. Because the results of the survey-adjusted tests account for correlation among participants sampled within the same cluster, and the possibility of having related individuals sampled from the same household, the authors recommend use of this test when analyzing genetic data originating from sample surveys with complex survey designs to assess deviations from Hardy-Weinberg equilibrium.

  6. Graphical tests for Hardy-Weinberg equilibrium based on the ternary plot.

    Science.gov (United States)

    Graffelman, Jan; Camarena, Jair Morales

    2008-01-01

    We design a graphical test for Hardy-Weinberg equilibrium. This can circumvent the calculation of p values and the statistical (non)significance of a large number of bi-allelic markers can be inferred from their position in a graph. By rewriting expressions for the chi(2) statistic (with and without continuity correction) in terms of the heterozygote frequency an acceptance region for Hardy-Weinberg equilibrium is obtained that can be depicted in a ternary plot. We obtain equations for curves in the ternary plot that separate markers that are out of Hardy-Weinberg equilibrium from those that are in equilibrium. The curves depend on the chosen significance level, the sample size and on a continuity correction parameter. Some examples of graphical tests using a set of 106 SNPs on the long arm of human chromosome 22 are described. Significant markers and poor markers with a lot of missing values are easily identified in the proposed plots. R software for making the diagrams is provided. The proposed graphs can be used as control charts for spotting problematic markers in large scale genotyping studies, and constitute an excellent tool for the graphical exploration of bi-allelic marker data. (c) 2007 S. Karger AG, Basel.

  7. Global convergence properties in multilocus viability selection models: the additive model and the Hardy-Weinberg law.

    Science.gov (United States)

    Karlin, S; Liberman, U

    1990-01-01

    A natural coordinate system is introduced for the analysis of the global stability of the Hardy-Weinberg (HW) polymorphism under the general multilocus additive viability model. A global convergence criterion is developed and used to prove that the HW polymorphism is globally stable when each of the loci is diallelic, provided the loci are overdominant and the multilocus recombination is positive. As a corollary the multilocus Hardy-Weinberg law for neutral selection is derived.

  8. [Competing risks of death and Hardy-Weinberg equilibrium in case-control studies of gene-disease association].

    Science.gov (United States)

    Llorca, Javier; Prieto-Salceda, Dolores; Combarros, Onofre; Dierssen-Sotos, Trinidad; Berciano, José

    2005-01-01

    To study the impact of competing risks on Hardy-Weinberg equilibrium and their consequences in case-control studies of gene-late onset disease association. Based on a population born in Hardy-Weinberg equilibrium for a particular gene, the genetic composition when the gene is associated with a lethal early-onset disease and its consequences on a late-onset disease can be deduced. Odds ratios estimates are unbiased in case-control studies when controls are sampled by density, even if the controls are in Hardy-Weinberg disequilibrium. An example in which a mutant gene is associated with early mortality is presented, producing a departure from Hardy-Weinberg equilibrium; as a result, controls in later ages are in disequilibrium, producing an odds ratio equal to 1.61. Although the main causes of Hardy-Weinberg disequilibrium in controls are selection bias or genotyping error, a competing risk of death associated with the mutant gene would also result in Hardy-Weinberg disequilibrium among controls.

  9. Interview with Professor Mark Wilcox.

    Science.gov (United States)

    Wilcox, Mark

    2016-08-01

    Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of the UK C. difficile Reference Laboratory for Public Health England (PHE). He was the Director of Infection Prevention (4 years), Infection Control Doctor (8 years) and Clinical Director of Pathology (6 years) at the Leeds Teaching Hospitals. He is Chair of PHE's Rapid Review Panel (reviews utility of infection prevention and control products for National Health Service), Deputy Chair of the UK Department of Health's Antimicrobial Resistance and Healthcare Associated Infection Committee and a member of PHE's HCAI/AR Programme Board. He is a member of UK/European/US working groups on C. difficile infection. He has provided clinical advice as part of the FDA/EMA submissions for the approval of multiple novel antimicrobial agents. He heads a healthcare-associated infection research team at University of Leeds, comprising approximately 30 doctors, scientists and nurses; projects include multiple aspects of C. difficile infection, diagnostics, antimicrobial resistance and the clinical development of new antimicrobial agents. He has authored more than 400 publications, and is the coeditor of Antimicrobial Chemotherapy (5th/6th/7th Editions, 15 December 2007).

  10. Professor Gender, Age, and "Hotness" in Influencing College Students' Generation and Interpretation of Professor Ratings

    Science.gov (United States)

    Sohr-Preston, Sara L.; Boswell, Stefanie S.; McCaleb, Kayla; Robertson, Deanna

    2016-01-01

    A sample of 230 undergraduate psychology students rated their expectations of a bogus professor (who was randomly designated a man or woman and "hot" versus "not hot") based on ratings and comments found on RateMyProfessors.com. Five professor qualities were derived using principal components analysis: dedication,…

  11. 'Supermentoring' of assistant professors' teaching

    DEFF Research Database (Denmark)

    Lauridsen, Ole

    Aarhus University offers a mandatory pedagogical training program for assistant professors, required in order to obtain tenure at a Danish university. At Business and Social Sciences, this program is supplemented by voluntary observation and (first of all formative) supervision of the assistant...... professors’ teaching practice. This offer is given is (i) because many young university teachers face problems putting pedagogical theory into practice – even though the program mentioned is practice-oriented, and (ii) because many of them (partly due to (i)) lack self-confidence as to teaching....... The presentation will discuss the theoretical framework of the supervision given and compare it to other supervision models. Furthermore it will address the need of working with supervision in a SOTL context. Attendees will be activated through discussion of short prototypical cases. A possible – and desired...

  12. Observations on Professor Hayek's Plan

    Directory of Open Access Journals (Sweden)

    Ludwig von Mises

    2009-01-01

    Full Text Available This memorandum was written at the request of Henry Hazlitt to provide Mises’s comments on and concerns about F.A. Hayek’s initial proposals for what became the Mont Pèlerin Society. Mises stresses that those who favor liberty and freedom and oppose totalitarianism must also oppose interventionism. The memo argues that those who fought and lost against the rising tide of totalitarianism at the turn of the 20th Century lost their battles because they settled for middle-of-the-road policies that conceded considerable ground to the socialists. The weak point in Professor Hayek’s plan is that it relies upon the cooperation of many men who are today’s middle-of-the-roaders. As interventionists, they may not be the hoped-for intellectual pioneers to inspire people to build a freer world.

  13. Professor Camillo Negro's Neuropathological Films.

    Science.gov (United States)

    Chiò, Adriano; Gianetto, Claudia; Dagna, Stella

    2016-01-01

    Camillo Negro, Professor in Neurology at the University of Torino, was a pioneer of scientific film. From 1906 to 1908, with the help of his assistant Giuseppe Roasenda and in collaboration with Roberto Omegna, one of the most experienced cinematographers in Italy, he filmed some of his patients for scientific and educational purposes. During the war years, he continued his scientific film project at the Military Hospital in Torino, filming shell-shocked soldiers. In autumn 2011, the Museo Nazionale del Cinema, in partnership with the Faculty of Neurosciences of the University of Torino, presented a new critical edition of the neuropathological films directed by Negro. The Museum's collection also includes 16 mm footage probably filmed in 1930 by Doctor Fedele Negro, Camillo's son. One of these films is devoted to celebrating the effects of the so-called "Bulgarian cure" on Parkinson's disease.

  14. How College Students View a Professor's Role

    Science.gov (United States)

    Gadzella, Bernadette M.

    1977-01-01

    Views of 3,670 students from six colleges and universities on most and least important traits of an ideal professor were analyzed. All data were collected with the same instrument. Data revealed students selected similar MOST and LEAST important traits of a quality professor. (Author)

  15. Finnish Students' Perceptions of a Visiting Professor.

    Science.gov (United States)

    Haussler, Susan C.; Paavilainen, Eija; Astedt-Kurki, Paivi

    2003-01-01

    Finnish nursing students (n=31) evaluated their experience with a visiting Fulbright professor. Students were satisfied with course content, teaching methods, and information about the U.S. health care system. They thought the professor should have been more knowledgeable about Finnish culture, education, and health care. (Contains 15 references.)…

  16. Professor Delight: Cultivating Organizational Citizenship Behavior

    Science.gov (United States)

    Mazen, Abdelmagid; Herman, Susan; Ornstein, Suzyn

    2008-01-01

    This article describes the rationale for and use of a class innovation the authors call "professor delight." This inexpensive, high-yield concept allows students and professors to enact their understanding of citizenship throughout the term, and often beyond. The authors explain the concept, describe its implementation in class, and link it to the…

  17. Testing Hardy-Weinberg equilibrium with a simple root-mean-square statistic.

    Science.gov (United States)

    Ward, Rachel; Carroll, Raymond J

    2014-01-01

    We provide evidence that, in certain circumstances, a root-mean-square test of goodness of fit can be significantly more powerful than state-of-the-art tests in detecting deviations from Hardy-Weinberg equilibrium. Unlike Pearson's $\\chi ^2$ test, the log-likelihood-ratio test, and Fisher's exact test, which are sensitive to relative discrepancies between genotypic frequencies, the root-mean-square test is sensitive to absolute discrepancies. This can increase statistical power, as we demonstrate using benchmark data sets and simulations, and through asymptotic analysis.

  18. Calculation and use of the Hardy-Weinberg model in association studies.

    Science.gov (United States)

    Ryckman, Kelli; Williams, Scott M

    2008-04-01

    Hardy-Weinberg equilibrium (HWE) is an important tool for understanding population structure. If certain assumptions are met, genotype and allele frequencies can be estimated from one generation to the next. In genetic association studies, HWE principles have been applied to detect genotyping error and disease susceptibility loci. The focus of this unit is to review the key principles and assumptions of HWE. There is a brief discussion on how the significance of HWE is tested, and a review of current applications of HWE in association studies. The applications discussed include estimating penetrance, evaluating genotyping errors, testing for population stratification, and testing for association. Copyright 2008 by John Wiley & Sons, Inc.

  19. Simple test for the Hardy-Weinberg law for HLA data with no observed double blanks.

    Science.gov (United States)

    Nam, J

    1995-03-01

    Eguchi and Matsuura (1990, Biometrics 46, 415-426) noted that the generalized Stevens test statistic for the Hardy-Weinberg law for human leukocyte antigen (HLA) data yields an excessively large value when no double blanks are observed. In this paper, we investigated this aberrant case. The inflated value of the test statistic is caused mainly by a seriously biased Bernstein's estimator of the recessive. We propose the generalized Stevens test using bias-corrected Bernstein's estimators for HLA data with no observed double blanks. An example illustrates the correction of the test statistic.

  20. A test for genetic association that incorporates information about deviation from Hardy-Weinberg proportions in cases.

    Science.gov (United States)

    Wang, Jian; Shete, Sanjay

    2008-07-01

    For assessment of genetic association between single-nucleotide polymorphisms (SNPs) and disease status, the logistic-regression model or generalized linear model is typically employed. However, testing for deviation from Hardy-Weinberg proportion in a patient group could be another approach for genetic-association studies. The Hardy-Weinberg proportion is one of the most important principles in population genetics. Deviation from Hardy-Weinberg proportion among cases (patients) could provide additional evidence for the association between SNPs and diseases. To develop a more powerful statistical test for genetic-association studies, we combined evidence about deviation from Hardy-Weinberg proportion in case subjects and standard regression approaches that use case and control subjects. In this paper, we propose two approaches for combining such information: the mean-based tail-strength measure and the median-based tail-strength measure. These measures integrate logistic regression and Hardy-Weinberg-proportion tests for the study of the association between a binary disease outcome and an SNP on the basis of case- and control-subject data. For both mean-based and median-based tail-strength measures, we derived exact formulas to compute p values. We also developed an approach for obtaining empirical p values with the use of a resampling procedure. Results from simulation studies and real-disease studies demonstrate that the proposed approach is more powerful than the traditional logistic-regression model. The type I error probabilities of our approach were also well controlled.

  1. Memorial to Professor Antonio Barone

    Science.gov (United States)

    Tafuri, Francesco; Pepe, Giampiero; Vaglio, Ruggero

    2014-04-01

    Antonio Barone prematurely passed away on 4 December 2011 at the age of 72, after a one-year battle with cancer. He left behind his wife Sveva and his two sons, Alberto and Livio. Antonio was Professor Emeritus at the University of Napoli Federico II, where he had been teaching for about 40 years. The initial research activity of Antonio was in the field of nuclear physics. In this context, almost 45 years ago, the Ge 'Lithium drift' semiconductor detectors represented a novelty, due to the high energy resolution enabled by those devices. Superconductors stimulated new approaches to radiation detection and this motivated Antonio's interest towards superconductivity. Following the birth of the Laboratorio di Cibernetica of the CNR in 1967 he was given the opportunity to work on a joint USA-Italy project (University of Wisconsin, Madison and CNR Naples) in the field of superconductivity on the peculiar subject of the superconductive 'Neuristors'. His research activity on Josephson junctions opened up a wide variety of very stimulating subjects in which he was deeply involved, ranging from the soliton propagation in 'long' Josephson structures to fluctuations phenomena, from light-sensitive junctions and proximity effect to the development of innovative superconducting devices. The strong interaction of Antonio with the Landau Institute for Theoretical Physics of the Academy of Sciences in Moscow, characterizes a long period of his research activity with a precious merging of theoretical and experimental aspects. This body of work converged into the famous monograph on the 'Physics and Applications of the Josephson Effect', written in collaboration with Gianfranco Paternò in 1982. This rapidly became the reference text for the Josephson effect, as documented by thousands of citations and the fact that it was translated into Russian, Japanese and Chinese. In 1983 Antonio was awarded the highest academic title of 'Doctor of the Physical-Mathematical Sciences' by the

  2. The second coming of Christ as the golden key to unlock the Book of Daniel: an analysis of a Pentecostal interpretation of the dream in Daniel 2

    OpenAIRE

    M. Nel

    2008-01-01

    Pentecostals regard the doctrine of the second coming of Christ as very important. All passages in the Bible deemed to be “prophetical” are interpreted in premillennialist terms. Bennie Kleynhans’ interpretation of the dream in Daniel 2 is used to demonstrate how an endeavour to find relevance through a contemporary interpretation of a Biblical passage, easily be- comes outdated. He was of the opinion that communism, the Council on Foreign Relations and the European Economic Community...

  3. The second coming of Christ as the golden key to unlock the Book of Daniel: an analysis of a Pentecostal interpretation of the dream in Daniel 2

    Directory of Open Access Journals (Sweden)

    M. Nel

    2008-07-01

    Full Text Available Pentecostals regard the doctrine of the second coming of Christ as very important. All passages in the Bible deemed to be “prophetical” are interpreted in premillennialist terms. Bennie Kleynhans’ interpretation of the dream in Daniel 2 is used to demonstrate how an endeavour to find relevance through a contemporary interpretation of a Biblical passage, easily be- comes outdated. He was of the opinion that communism, the Council on Foreign Relations and the European Economic Community with its ten members would introduce the Antichrist as the leader of a one-world government, eventually leading to the second coming of Christ. Daniel 2 is read as “prophecy”, describing the global situation at the latter half of the twentieth century. This demonstrates that the differences in interpreting the dream in Daniel 2 reflect different ways of viewing and treating the Bible. A fundamentalist perspective sees the Bible as a blueprint of what God is going to do in future and how he is going to do this. The “future” – the “last days” just before the second coming of Christ – is inevitably linked to the present day.

  4. Think Twice: Review of Thinking, Fast and Slow by Daniel Kahneman (2011)

    OpenAIRE

    Anne Kelly

    2017-01-01

    Daniel Kahneman. Thinking, Fast and Slow (New York, NY: Farrar, Straus and Giroux) 499 pp. ISBN 978-0374275631. In Thinking, Fast and Slow, Nobel Prize-winning psychologist Daniel Kahneman significantly sharpens our understanding of human decision-making and the systems of thinking that underlie it. He offers a compelling critique of the rational-agent model, arguing that, while we can and do use reason, we often fall back on a type of thinking that operates quickly and requires less cogn...

  5. Think Twice: Review of Thinking, Fast and Slow by Daniel Kahneman (2011

    Directory of Open Access Journals (Sweden)

    Anne Kelly

    2017-07-01

    Full Text Available Daniel Kahneman. Thinking, Fast and Slow (New York, NY: Farrar, Straus and Giroux 499 pp. ISBN 978-0374275631. In Thinking, Fast and Slow, Nobel Prize-winning psychologist Daniel Kahneman significantly sharpens our understanding of human decision-making and the systems of thinking that underlie it. He offers a compelling critique of the rational-agent model, arguing that, while we can and do use reason, we often fall back on a type of thinking that operates quickly and requires less cognitive effort but is vulnerable to faulty belief.

  6. Pseudo-random mating populations. In celebration of the 80th anniversary of the Hardy-Weinberg law.

    Science.gov (United States)

    Li, C C

    1988-07-01

    That random mating leads to Hardy-Weinberg distribution of genotypes is well known. This report is to show that, if the deviations from random mating are of a certain pattern, the offspring generation will also be in Hardy-Weinberg proportions. This brings out the fact that random mating is a sufficient condition, not a necessary one, for the attainment of the Hardy-Weinberg proportions. Such nonrandom-mating populations are tentatively said to be pseudo-random mating. Pseudo-random-mating populations exist for both autosomal and sex-linked systems with two or multiple alleles. This report covers the basic case of a two-allele autosomal locus in detail, but the possible extension to two loci and cytonuclear systems have also been mentioned in discussion.

  7. A genome-wide study of Hardy-Weinberg equilibrium with next generation sequence data.

    Science.gov (United States)

    Graffelman, Jan; Jain, Deepti; Weir, Bruce

    2017-06-01

    Statistical tests for Hardy-Weinberg equilibrium have been an important tool for detecting genotyping errors in the past, and remain important in the quality control of next generation sequence data. In this paper, we analyze complete chromosomes of the 1000 genomes project by using exact test procedures for autosomal and X-chromosomal variants. We find that the rate of disequilibrium largely exceeds what might be expected by chance alone for all chromosomes. Observed disequilibrium is, in about 60% of the cases, due to heterozygote excess. We suggest that most excess disequilibrium can be explained by sequencing problems, and hypothesize mechanisms that can explain exceptional heterozygosities. We report higher rates of disequilibrium for the MHC region on chromosome 6, regions flanking centromeres and p-arms of acrocentric chromosomes. We also detected long-range haplotypes and areas with incidental high disequilibrium. We report disequilibrium to be related to read depth, with variants having extreme read depths being more likely to be out of equilibrium. Disequilibrium rates were found to be 11 times higher in segmental duplications and simple tandem repeat regions. The variants with significant disequilibrium are seen to be concentrated in these areas. For next generation sequence data, Hardy-Weinberg disequilibrium seems to be a major indicator for copy number variation.

  8. The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium.

    Science.gov (United States)

    Sato, Yasunori; Suganami, Hideki; Hamada, Chikuma; Yoshimura, Isao; Sakamoto, Hiromi; Yoshida, Teruhiko; Yoshimura, Kimio

    2006-01-01

    In single nucleotide polymorphism (SNP) data analysis, the allelic odds ratio and its confidence interval (CI) are usually used to evaluate the association between disease and alleles at each SNP. The usual formula for calculating the CI of the allelic odds ratio based on the Hardy-Weinberg equilibrium (HWE) may, however, lead to errors beyond the control assured by the nominal confidence level if HWE is not true. We therefore present a generalized formula for CI that does not assume HWE. CIs calculated by this generalized formula are likely to be wider than those by the usual method if the Hardy-Weinberg disequilibrium (HWD) is toward a relative deficiency of the heterozygotes (fixation index greater than 0), whereas they are likely to be narrower if HWD is toward a relative excess of the heterozygotes (fixation index less than 0). A simulation experiment to examine the influence of the generalization was performed for the case where 2% of SNPs had a fixation index greater than 0. The result revealed that the generalized method slightly decreased the mean number of falsely detected SNPs.

  9. ANALISIS TINGKAT OPTIMASI ALGORITMA GENETIKA DALAM HUKUM KETETAPAN HARDY-WEINBERG PADA BIN PACKING PROBLEM

    Directory of Open Access Journals (Sweden)

    Terry Noviar Panggabean

    2016-08-01

    Full Text Available Abstrak—Karna representasi abstrak dari beberapa sistem pengambilan keputusan yang nyata dalam kehidupan sehari hari membuat masalah optimasi kombinatorial umumnya sangat sulit untuk dipecahkan. Bin packing problem ialah solusi terbaik dalam mengatasi masalah optimasi kombinatorial, yang digunakan untuk mencari sebuah objek secara optimal dari sekelompok himpunan objek yang berhingga. Serangkaian pendekatan hybrid telah dikembangkan dalam hal ini untuk memecahkan masalah Bin Packing. Metaheuristik adalah salah satu pendekatan tingkat tinggi dalam memandu dalam memodifikasi beberapa metode heuristik lainnya untuk mencari tingkat optimasi yang lebih baik. Genetic Algorithm atau Algoritma Genetika juga merupakan metode metaheuristik yang digunakan untuk menyelesaikan berbagai masalah dalam hal peningkatan optimasi. Dalam algoritma genetika terdapat bermacam-macam varian. Dalam penelitian dipaparkan mengenai taksonomi dari algoritma genetika parallel (Parallel Genetic Algorithm yang memiliki kemampuan yang lebih baik dari algoritma genetika konvensional dalam hal kinerja dan skalabilitasnya. Tetapi algoritma genetika paralel ini hanya cocok untuk permasalahan jaringan komputer heterogen dan sistem terdistribusi. Berdasarkan penelitian yang sudah pernah dilakukan sebelumnya dan dari uraian diatas maka penulis tertarik untuk melakukan penelitian bagaimana menerapkan hukum ketetapan Hardy-Weinberg dari bidang biologi kedalam algoritma genetika melakukan analisis tingkat optimasi terhadap Bin Packing Problem..   Keywords— Genetic Algortihm, Hardy-Weinberg, Bin Packing Problem.

  10. Performing the exact test of Hardy-Weinberg proportion for multiple alleles.

    Science.gov (United States)

    Guo, S W; Thompson, E A

    1992-06-01

    The Hardy-Weinberg law plays an important role in the field of population genetics and often serves as a basis for genetic inference. Because of its importance, much attention has been devoted to tests of Hardy-Weinberg proportions (HWP) over the decades. It has long been recognized that large-sample goodness-of-fit tests can sometimes lead to spurious results when the sample size and/or some genotypic frequencies are small. Although a complete enumeration algorithm for the exact test has been proposed, it is not of practical use for loci with more than a few alleles due to the amount of computation required. We propose two algorithms to estimate the significance level for a test of HWP. The algorithms are easily applicable to loci with multiple alleles. Both are remarkably simple and computationally fast. Relative efficiency and merits of the two algorithms are compared. Guidelines regarding their usage are given. Numerical examples are given to illustrate the practicality of the algorithms.

  11. The size of the chi-square test for the Hardy-Weinberg law.

    Science.gov (United States)

    Kang, Seung-Ho; Shin, Dongwan

    2004-01-01

    Many scientific problems can be formulated in terms of a statistical model indexed by parameters, only some of which are of scientific interest and the other parameters, called nuisance parameters, are not of interest in themselves. For testing the Hardy-Weinberg law, a relation among genotype and allele probabilities is of interest and allele probabilities are of no interest and now nuisance parameters. In this paper we investigate how the size (the maximum of the type I error rate over the nuisance parameter space) of the chi-square test for the Hardy-Weinberg law is affected by the nuisance parameters. Whether the size is well controlled or not under the nominal level has been frequently investigated as basic components of statistical tests. The size represents the type I error rate at the worst case. We prove that the size is always greater than the nominal level as the sample size increases. Extensive computations show that the size of the chi-squared test (worst type I error rate over the nuisance parameter space) deviates more upwardly from the nominal level as the sample size gets larger. The value at which the maximum of the type I error rate was found moves closer to the edges of the the nuisance parameter space with increasing sample size. An exact test is recommended as an alternative when the type I error is inflated. 2004 S. Karger AG, Basel.

  12. Lectures on quantum mechanics; Quantenmechanik. Eine Einfuehrung des Nobelpreistraegers Steven Weinberg

    Energy Technology Data Exchange (ETDEWEB)

    Weinberg, Steven [Texas Univ., Austin, TX (United States). Dept. fuer Physik und Astronomie

    2015-07-01

    Quantum mechanics represents the central revolution of modern natural science and reaches in its importance farely beyond physics. Neither chemistry nor biology on the molecular scale would be understandable without it. Modern information technology from the laptop over the mobile telephone and the flat screen until the supercomputer would be unthinkable without quantum-mechanical effects. It desribes the world on the atomic and subatomic scale and is by this the starting point of our modern worldview. The Nobel-prize carrier Steven Weinberg has done ever among others by his theory of the unification of the weak and the electromagnetic interaction one of the most important contributions to this revolution. In this book he reproduces his personal view of quantum mechanics, which captivates by its strictly logic construction, precise linguistic representation, and mathematical clearness and completeness. This book appeals to studyings of natural sciences, especially of physics. Accompanied is the test by exercise problems, which allow the studying to apply immediately the knowledge, but also test their understanding. Because of its precision and clearness ''Lectures on Quantum Mechanics'' by Weinberg is also essentially suited for the self-study.

  13. Quieting Weinberg 5C: a case study in hospital noise control.

    Science.gov (United States)

    MacLeod, Mark; Dunn, Jeffrey; Busch-Vishniac, Ilene J; West, James E; Reedy, Anita

    2007-06-01

    Weinberg 5C of Johns Hopkins Hospital is a very noisy hematological cancer unit in a relatively new building of a large medical campus. Because of the requirements for dealing with immuno-suppressed patients, options for introducing sound absorbing materials are limited. In this article, a case study of noise control in a hospital, the sound environment in the unit before treatment is described, the chosen noise control approach of adding custom-made sound absorbing panels is presented, and the impact of the noise control installation is discussed. The treatment of Weinberg 5C involved creating sound absorbing panels of 2-in.-thick fiberglass wrapped in an anti-bacterial fabric. Wallpaper paste was used to hold the fabric to the backing of the fiberglass. Installation of these panels on the ceiling and high on corridor walls had a dramatic effect. The noise on the unit (as measured by the equivalent sound pressure level) was immediately reduced by 5 dB(A) and the reverberation time dropped by a factor of over 2. Further, this drop in background noise and reverberation time understates the dramatic impact of the change. Surveys of staff and patients before and after the treatment indicated a change from viewing the unit as very noisy to a view of the unit as relatively quiet.

  14. PROFESSORES: IMAGENS DO FUTURO PRESENTE

    Directory of Open Access Journals (Sweden)

    Maitê Alves Bezerra

    2014-06-01

    Full Text Available Ao observar a comunidade portuguesa que busca compreender a historicidade das formas e dos processos de escolarização por meio do estabelecimento de intenso diálogo com outras comunidades, é impossível não dar destaque à figura de António Manuel Seixas Nóvoa. Nascido em Lisboa no ano de 1954, aos 18 anos inicia o curso de Ciências da Educação na Universidade de Lisboa. Após lecionar em importantes universidades tais como Paris V, Oxford e Columbia University, atualmente acumula as posições de reitor da Universidade de Lisboa e professor catedrático da Faculdade de Psicologia e de Ciências da Educação na Instituição. Nóvoa tem se destacado à frente de debates internacionais a respeito da história da educação e educação comparada.

  15. E. Valentine Daniel: Fluid Signs - Being a Person the Tamil Way

    DEFF Research Database (Denmark)

    Kjærholm, Lars

    2007-01-01

    en diskussion af de generelle muligheder for at anvende C.S. Peirce's semiotiske teorier i antropologisk analyse, og en specifik fremstilling og diskussion af hvorvidt det lykkes for E. Valentine Daniel at demonstrere værdien af disse teorier i antropologisk feltarbejde og analyse...

  16. Azpiazu, Daniel, La concentración en la industria argentina a principios del siglo XXI

    Directory of Open Access Journals (Sweden)

    Patricia Jerez

    2013-01-01

    Full Text Available Azpiazu, Daniel, La concentración en la industria argentina a principios del siglo XXI, Buenos Aires, Cara o Ceca/Centro Cultural de la Cooperación Floreal Gorini/Editorial Atuel, 2011 (148 págs.

  17. A clash of gods – Conceptualising space in Daniel 1 | de Bruyn ...

    African Journals Online (AJOL)

    Applying cognitive linguistics to the text of Daniel 1 is a useful exegetical aid for a better understanding of the narrative. Studying the author's use of 'spatial markers' such as 'Jerusalem', 'Babylon', 'temple' and some other spatial features, makes it possible to reconstruct the narrative into a 'cognitive spatial frameset'. In this ...

  18. USA välisminister Daniel Fried : "Me ei taha nõrka Venemaad"

    Index Scriptorium Estoniae

    2007-01-01

    Ilmunud ka: Severnoje Poberezhje, 12. mai 2007, lk. 5. USA asevälisminister Euroopa ja Euraasia küsimustes Daniel Fried märkis Saksamaal toimunud Euroopa foorumil, et Venemaaga suhtlemiseks ja koostöö tegemiseks on vaja luua ühine koostööraamistik

  19. Nontimber forest products in Daniel Boone National Forest region--economic significance and potential for sustainability

    Science.gov (United States)

    Dasharathi Hembram; William L. Hoover

    2008-01-01

    Household members who gather nontimber forest products (NTFP) in and around the Daniel Boone National Forest (DBNF) in eastern Kentucky were interviewed. Participants reported that a wide variety of NTFP were economically and culturally important to them. Forty-three species of plants were sold commercially and 120 were used in households. Ginseng (Panax...

  20. Daniel Landis: Award for Distinguished Contributions to the International Advancement of Psychology

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents a short biography of one of the co-recipients of the American Psychological Association's Award for Distinguished Contributions to the International Advancement of Psychology. One of the 2012 winners is Daniel Landis for his unparalleled contribution to the field of intercultural research in a distinguished academic career spanning almost…

  1. Virginia Tech Corps of Cadets alumnus Daniel Richardson named Central Michigan game Hokie Hero

    OpenAIRE

    Cox, Carrie

    2010-01-01

    Virginia Tech Corps of Cadets alumnus Capt. Daniel Richardson, U.S. Air Force, who earned a degree in industrial and systems engineering from the College of Engineering and a minor in leadership studies from the Virginia Tech Corps of Cadets Rice Center for Leader Development in 2004 has been selected as the Hokie Hero for the Virginia Tech versus Central Michigan University game.

  2. The Coming Right-Brain Economy: Daniel H. Pink Says the MFA Is the New MBA

    Science.gov (United States)

    Connection: The Journal of the New England Board of Higher Education, 2005

    2005-01-01

    According to a recent "Harvard Business Review" piece by author Daniel H. Pink, MBA graduates are, in many ways, becoming this century's blue-collar workers--people who entered a workforce that was full of promise only to see their jobs move overseas. At the same time, businesses are realizing that the only way to differentiate their goods and…

  3. [Jean-Daniel Strub. Der gerechte Friede. Spannungsfelder eines friedensethnischen Leibegriffs.] / Andreas Pawlas

    Index Scriptorium Estoniae

    Pawlas, Andreas

    2012-01-01

    Arvustus: Strub, Jean-Daniel. Der gerechte Friede. Spannungsfelder eines friedensethnischen Leibegriffs. (Forum Systematik. beiträge zur Dogmatik, Ethik und ökumenischen Theologie, hg von Johannes Brosseder, Johannes Fischer und Joachim Track, Band 36), Verlag W. Kohlhammer, Stuttgart 2010

  4. Deniel Kreig : Polutshiv rol Dzheimsa Bonda, ja napilsja ot stshastja! / Daniel Craig ; interv. Stass Tõrkin

    Index Scriptorium Estoniae

    Craig, Daniel

    2006-01-01

    Ajakirjanikud Londonis uue Bondi-filmi "007: Casino Royale" esilinastusel ja pressikonverentsil. Näitleja Daniel Craig räägib endast, oma Bondi karakterist. Lisaks kõigi Bondi osatäitjate lühiandmed "Vse sekretnõje agentõ", kuulsaimad Bondi tüdrukud "7 samõh seksualnõh devushek agenta 007"

  5. A literary-historical analysis of Daniel 2 : Two powers in opposition ...

    African Journals Online (AJOL)

    This article investigates some aspects of Daniel 2 and attempts to demonstrate the value of the literary-historical approach to biblical texts. The literary-historical approach consists of three elements: a structural, a historical and a narrative analysis of the text. Firstly, the structural investigation uses Propps model for a ...

  6. Violence and the Daniel tales in a children's bible | Nel | HTS ...

    African Journals Online (AJOL)

    Children enjoy the tales of Daniel and his three friends, whether told in Sunday school, day school, by parents or grandparents. These tales are cast essentially in violent terms. In this article a specific version of the tales in a children's Bible is analysed to show in what way violence serves as the thread that holds the tales ...

  7. What the Butler Saw: Lee Daniels's Studies in Biography and History

    Science.gov (United States)

    Beck, Bernard

    2014-01-01

    The movie "Lee Daniels' The Butler" is an example of a work that is meant not only to entertain but to convey an important attitude and offer important viewpoints. The movie deals with a deep issue in the history of movies and the history of the country: racial inequality. Three issues are discussed in this article: (a) African…

  8. Daniel Day-Lewis lihvis Oscari-rolli neli aastat / Triin Tael

    Index Scriptorium Estoniae

    Tael, Triin

    2008-01-01

    Paul Thomas Andersoni Upton Sinclairi "Õli" järgi lavastatud "Veri hakkab voolama" ("There Will Be Blood"), peaosas Daniel Day-Lewis : Ameerika Ühendriigid 2007. Näitleja võitis oma rolliga parima meespeaosatäitja Oscari. Tema tööst rolli(de)ga

  9. A literary-historical analysis of Daniel 2 : Two powers in opposition ...

    African Journals Online (AJOL)

    Firstly, the structural investigation uses Propps model for a functional analysis of the text, followed by a semiotic analysis to identify the functions and qualifications ... The narrator of Daniel 2 conveys two persuasions to her readers: she emphasises the sovereign rule of God, not only in Jerusalem but also in Babylon, and the ...

  10. Professor dr hab. Anna Maria Bujakiewicz

    Directory of Open Access Journals (Sweden)

    Anna Kujawa

    2015-08-01

    Full Text Available The article presents the biography and scientific achievements of Professor Anna Bujakiewicz. After receiving her master’s degree and doctorate in biology and mycology from Adam Mickiewicz University in Poznań, Professor Bujakiewicz continued her exciting research and teaching on mycology at her Alma Mater Posnaniensis for more than 50 years. Her publications in this field include many books, articles, and other scholarly reports.

  11. Differences between Male Students' and Female Students' Perception of Professors

    Science.gov (United States)

    Tomkiewicz, Joseph; Bass, Kenneth

    2008-01-01

    This study is an empirical examination of possible differences between female and male college seniors' perceptions between male and female college professors. Subjects were presented with three variations of a scale designed to measure students' perceptions of university professors in general, female professors, and male professors. These…

  12. The Coleman-Weinberg mechanism in a conformal (Weyl) invariant theory: application to a magnetic monopole

    Science.gov (United States)

    Edery, Ariel; Graham, Noah

    2015-05-01

    We consider a massless conformally (Weyl) invariant classical action consisting of a magnetic monopole coupled to gravity in an anti-de Sitter background spacetime. We implement quantum corrections and this breaks the conformal (Weyl) symmetry, introduces a length scale via the process of renormalization and leads to the trace anomaly. We calculate the one-loop effective potential and determine from it the vacuum expectation value (VEV). Spontaneous symmetry breaking is radiatively induced a la Coleman-Weinberg and the scalar coupling constant is exchanged for the dimensionful VEV via dimensional transmutation. An important result is that the Ricci scalar of the AdS background spacetimeis determined entirely by the value of the VEV.

  13. Feynman-Weinberg Quantum Gravity and the Extended Standard Model as a Theory of Everything

    CERN Document Server

    Tipler, Frank J

    2005-01-01

    I argue that the (extended) Standard Model (SM) of particle physics and the renormalizable Feynman-Weinberg theory of quantum gravity comprise a theory of everything. I show that imposing the appropriate cosmological boundary conditions make the theory finite. The infinities that are normally renormalized away and the series divergence infinities are both eliminated by the same mechanism. Furthermore, this theory can resolve the horizon, flatness, and isotropy problems of cosmology. Joint mathematical consistency naturally yields a scale-free, Gaussian, adiabatic perturbation spectrum, and more matter than antimatter. I show that mathematical consistency of the theory requires the universe to begin at an initial singularity with a pure $SU(2)_L$ gauge field. I show that quantum mechanics requires this field to have a Planckian spectrum whatever its temperature. If this field has managed to survive thermalization to the present day, then it would be the CMBR. If so, then we would have a natural explanation for...

  14. Hardy-Weinberg equilibrium revisited for inferences on genotypes featuring allele and copy-number variations.

    Science.gov (United States)

    Recke, Andreas; Recke, Klaus-Günther; Ibrahim, Saleh; Möller, Steffen; Vonthein, Reinhard

    2015-03-13

    Copy number variations represent a substantial source of genetic variation and are associated with a plethora of physiological and pathophysiological conditions. Joint copy number and allelic variations (CNAVs) are difficult to analyze and require new strategies to unravel the properties of genotype distributions. We developed a Bayesian hidden Markov model (HMM) approach that allows dissecting intrinsic properties and metastructures of the distribution of CNAVs within populations, in particular haplotype phases of genes with varying copy numbers. As a key feature, this approach incorporates an extension of the Hardy-Weinberg equilibrium, allowing both a comprehensive and parsimonious model design. We demonstrate the quality of performance and applicability of the HMM approach with a real data set describing the Fcγ receptor (FcγR) gene region. Our concept, using a dynamic process to analyze a static distribution, establishes the basis for a novel understanding of complex genomic data sets.

  15. Genuine Bayesian multiallelic significance test for the Hardy-Weinberg equilibrium law.

    Science.gov (United States)

    Pereira, C A B; Nakano, F; Stern, J M; Whittle, M R

    2006-10-31

    Statistical tests that detect and measure deviation from the Hardy-Weinberg equilibrium (HWE) have been devised but are limited when testing for deviation at multiallelic DNA loci is attempted. Here we present the full Bayesian significance test (FBST) for the HWE. This test depends neither on asymptotic results nor on the number of possible alleles for the particular locus being evaluated. The FBST is based on the computation of an evidence index in favor of the HWE hypothesis. A great deal of forensic inference based on DNA evidence assumes that the HWE is valid for the genetic loci being used. We applied the FBST to genotypes obtained at several multiallelic short tandem repeat loci during routine parentage testing; the locus Penta E exemplifies those clearly in HWE while others such as D10S1214 and D19S253 do not appear to show this.

  16. Exact tests of Hardy-Weinberg equilibrium and homogeneity of disequilibrium across strata.

    Science.gov (United States)

    Schaid, Daniel J; Batzler, Anthony J; Jenkins, Gregory D; Hildebrandt, Michelle A T

    2006-12-01

    Detecting departures from Hardy-Weinberg equilibrium (HWE) of marker-genotype frequencies is a crucial first step in almost all human genetic analyses. When a sample is stratified by multiple ethnic groups, it is important to allow the marker-allele frequencies to differ over the strata. In this situation, it is common to test for HWE by using an exact test within each stratum and then using the minimum P value as a global test. This approach does not account for multiple testing, and, because it does not combine information over strata, it does not have optimal power. Several approximate methods to combine information over strata have been proposed, but most of them sum over strata a measure of departure from HWE; if the departures are in different directions, then summing can diminish the overall evidence of departure from HWE. An exact stratified test is more appealing because it uses the probability of genotype configurations across the strata as evidence for global departures from HWE. We developed an exact stratified test for HWE for diallelic markers, such as single-nucleotide polymorphisms (SNPs), and an exact test for homogeneity of Hardy-Weinberg disequilibrium. By applying our methods to data from Perlegen and HapMap--a combined total of more than five million SNP genotypes, with three to four strata and strata sizes ranging from 23 to 60 subjects--we illustrate that the exact stratified test provides more-robust and more-powerful results than those obtained by either the minimum of exact test P values over strata or approximate stratified tests that sum measures of departure from HWE. Hence, our new methods should be useful for samples composed of multiple ethnic groups.

  17. Deviations from hardy-weinberg equilibrium in parental and unaffected sibling genotype data.

    Science.gov (United States)

    Li, Bingshan; Leal, Suzanne M

    2009-01-01

    Genotyping error can increase both type I and II errors. In order to elucidate potential genotyping errors, data quality control often includes testing genotype data for deviations from Hardy-Weinberg Equilibrium (HWE). The Hardy-Weinberg Disequilibrium (HWD) coefficient and the ability to reject the null hypothesis of HWE were calculated analytically for genotype data from parents and unaffected siblings of affected probands. Genotype data from parents and unaffected siblings display deviations from HWE when functional or markers in LD with functional locus are tested. For the parental genotype data all deviations from HWE are negative, indicating an excess of heterozygous genotypes with the strongest deviations from HWE observed for the multiplicative model. In contrast, for affected proband genotype data, there is no deviation from HWE under the multiplicative model and the deviations from HWE for the recessive model are positive. For the unaffected sibling data, patterns of deviation from HWE are similar to those observed in the proband data with the exception of the multiplicative model where the HWD coefficient although close to 0 can be either positive or negative depending on the allele frequency. Deviations from HWE in parental and unaffected sibling genotype data could be due to an association with the functional locus. However these deviations for genotypic relative risk < or =2.0 are not large and therefore the power to detect them is usually low. Testing for deviations from HWE in parental and unaffected sibling genotype data is still beneficial for quality control even though functional loci, in parental and unaffected sibling genotype data, can produce an association signal. Copyright 2008 S. Karger AG, Basel.

  18. Computationally feasible estimation of haplotype frequencies from pooled DNA with and without Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Kuk, Anthony Y C; Zhang, Han; Yang, Yaning

    2009-02-01

    Pooling large number of DNA samples is a common practice in association study, especially for initial screening. However, the use of expectation-maximization (EM)-type algorithms in estimating haplotype distributions for even moderate pool sizes is hampered by the computational complexity involved. A novel constrained EM algorithm called PoooL has been proposed recently to bypass the difficulty via the use of asymptotic normality of the pooled allele frequencies. The resulting estimates are, however, not maximum likelihood estimates and hence not optimal. Furthermore, the assumption of Hardy-Weinberg equilibrium (HWE) made may not be realistic in practice. Rather than carrying out constrained maximization as in PoooL, we revert to the usual EM algorithm but make it computationally feasible by using normal approximations. The resulting algorithm is much simpler to implement than PoooL because there is no need to invoke sophisticated iterative scaling methods as in PoooL. We also develop an estimating equation analogue of the EM algorithm for the case of Hardy-Weinberg disequilibrium (HWD) by conditioning on the haplotypes of both chromosomes of the same individual. Incorporated into the method is a way of estimating the inbreeding coefficient by relating it to overdispersion. Simulation study assuming HWE shows that our simplified implementation of the EM algorithm leads to estimates with substantially smaller SDs than PoooL estimates. Further simulations show that ignoring HWD will induce biases in the estimates. Our extended method with estimation of inbreeding coefficient incorporated is able to reduce the bias leading to estimates with substantially smaller mean square errors. We also present results to suggest that our method can cope with a certain degree of locus-specific inbreeding as well as additional overdispersion not caused by inbreeding. http://staff.ustc.edu.cn/ approximately ynyang/aem-aes

  19. Developing Graduate Students' Knowledge of Hardy-Weinberg Equilibrium through Lesson Study

    Science.gov (United States)

    Dotger, Sharon; Barry, Deborah; Wiles, Jason; Benevento, Elizabeth; Brzozowski, Frances; Hurtado-Gonzales, Jorge; Jacobs, Nicole; Royse, Ellen; Sen, Debjeet; Snyder, Julia; Stokes, Robert; Wisner, Ellen

    2012-01-01

    Existing research on the development of graduate students' teaching competency focuses on the need for their learning opportunities to be contextualized to their specific content area and course structure. A group of graduate teaching assistants collaborated with a biology professor and a science educator in a Japanese Lesson Study to directly…

  20. Accounting Professor Qualification in Digital Age: A Perception Study on Brazilian Professors

    Science.gov (United States)

    Vendruscolo, Maria Ivanice; Behar, Patrícia Alejandra

    2015-01-01

    This papers aims at analyzing the perception of Accounting professors about the necessary qualifications in Accounting undergraduate courses. The contribution of this study is to theoretically discuss the education of Accounting professors, with empirical data, because Accounting teaching requires specific competencies in the digital area. The…

  1. The housekeeper and the professor a novel

    CERN Document Server

    Ogawa, Yoko

    2010-01-01

    He is a brilliant math Professor with a peculiar problem—ever since a traumatic head injury, he has lived with only eighty minutes of short-term memory. She is an astute young Housekeeper—with a ten-year-old son—who is hired to care for the Professor. And every morning, as the Professor and the Housekeeper are introduced to each other anew, a strange and beautiful relationship blossoms between them. Though he cannot hold memories for long (his brain is like a tape that begins to erase itself every eighty minutes), the Professor's mind is still alive with elegant equations from the past. And the numbers, in all of their articulate order, reveal a sheltering and poetic world to both the Housekeeper and her young son. The Professor is capable of discovering connections between the simplest of quantities—like the Housekeeper's shoe size—and the universe at large, drawing their lives ever closer and more profoundly together, even as his memory slips away. Yoko Ogawa's The Housekeeper and the Professo...

  2. Office of Inspector General audit report on Fluor Daniel Fernald`s use of temporary services subcontractors

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The Department of Energy (Department) and Fluor Daniel Fernald (Fluor Daniel) implemented two work force restructurings at the Fernald Environmental Management Project between Fiscal Years (FY) 1994 and 1996. During the restructurings, the Department`s cost for temporary service subcontracts increased from $2.8 million to $9.8 million annually. The objective of this audit was to determine whether Fluor Daniel utilized temporary service agreements in an economical and efficient manner and in accordance with the policy and goals of the Department`s Work Force Restructuring Program.

  3. Violence and the Daniel tales in a children’s Bible

    Directory of Open Access Journals (Sweden)

    Marius Nel

    2009-09-01

    Full Text Available Children enjoy the tales of Daniel and his three friends, whether told in Sunday school, day school, by parents or grandparents. These tales are cast essentially in violent terms. In this article a specific version of the tales in a children’s Bible is analysed to show in what way violence serves as the thread that holds the tales together and to suggest that this might imply that violence is condoned, be it violence committed by God for the sake of his children or by his children for their own sakes. Through ideology, criticism and deconstruction it is shown how a socially engaged reading of the text necessitates narrators of the Daniel tales to criticise violence embedded within the Biblical text, especially when these tales are narrated to children.

  4. Violence and the Daniel tales in a children’s Bible

    Directory of Open Access Journals (Sweden)

    Marius Nel

    2009-08-01

    Full Text Available Children enjoy the tales of Daniel and his three friends, whether told in Sunday school, day school, by parents or grandparents. These tales are cast essentially in violent terms. In this article a specific version of the tales in a children’s Bible is analysed to show in what way violence serves as the thread that holds the tales together and to suggest that this might imply that violence is condoned, be it violence committed by God for the sake of his children or by his children for their own sakes. Through ideology, criticism and deconstruction it is shown how a socially engaged reading of the text necessitates narrators of the Daniel tales to criticise violence embedded within the Biblical text, especially when these tales are narrated to children.

  5. Disaini ja rahvaste saatusest / Daniel Van der Velden ; interv. Kristjan Mändmaa

    Index Scriptorium Estoniae

    Van der Velden, Daniel

    2008-01-01

    17.-27. X 2008 oli Eesti Kunstiakadeemias näitus "Marsilt. Omaalgatuslikud projektid graafilises disainis". Kuraatorid: tšehhi disainerid Adam Machacek ja Radim Peshko. 17. X esinesid EKA saalis loengutega James Goggin Londoni firmast Practice ja Daniel van der Velden Hollandi disainikollektiivist Metahaven. 16. V osales D. van der Velden Eesti Disainiinstituudi korraldatud kohabrändingu-teemalises ümarlauas. D. van der Velden disaini, poliitika ja kohabrändingu tulevikust, Metahaveni disainitöödest

  6. Disaini ja rahvaste saatusest / Daniel Van der Velden ; intervjueerinud Kristjan Mändmaa

    Index Scriptorium Estoniae

    Van der Velden, Daniel

    2011-01-01

    17.-27. X 2008 oli Eesti Kunstiakadeemias näitus "Marsilt. Omaalgatuslikud projektid graafilises disainis". Kuraatorid: tšehhi disainerid Adam Machacek ja Radim Peshko. 17. X esinesid EKA saalis loengutega James Goggin Londoni firmast Practice ja Daniel van der Velden Hollandi disainikollektiivist Metahaven. 16. V osales D. van der Velden Eesti Disainiinstituudi korraldatud kohabrändingu-teemalises ümarlauas. D. van der Velden disaini, poliitika ja kohabrändingu tulevikust, Metahaveni disainitöödest

  7. Business leadership concepts exemplified by the two exceptional leaders Daniel Vasella and Ricardo Semler

    OpenAIRE

    Szillat, Patrick; Betov, Alexander

    2016-01-01

    Purpose - Against the background of current leadership theory, this research paper analyses and compares the leadership approaches of two outstanding leaders: Daniel Vasella, chairman of the leading Swiss pharmaceutical organization Novartis and Ricardo Semler, owner of the Brazilian conglomerate Semco. In contrast to many rather abstract, unpractical and pointlessly theoretical papers on leadership this analysis provides a more applied view of leadership by means of the life history approach...

  8. Professor Karel Oštir zum andenken

    Directory of Open Access Journals (Sweden)

    Bojan Čop

    1973-12-01

    Full Text Available Die Redaktion der Zeitschrift tinguistica beschloss am Anfang des Jahres 1973, den XIII.Jg. der Vollendung des fünfundachtzigsten Lebensjahres, die Professor Karel Oštir am 13. Oktober feiern sollte, zu widmen. Da sich aber das Sammeln des Materials für diesen Jahrgang sowie der Druck des XII. Jahrganges allzusehr in die Länge gezogen hatten, ist uns das unerbittliche Schicksal zuvorgekommen: am 27. Dezember 1973 ist Professor Karel Oštir sanft entschlafen. Das Leben eines der eigenartigsten Sprachwissenschaftler aller Zei ten hat sich so erfüllt. Aus einer Festschrift musste nun eine Gedenkschrift werden.

  9. Professor Stewart's casebook of mathematical mysteries

    CERN Document Server

    Stewart, Ian

    2014-01-01

    Like its wildly popular predecessors Cabinet of Mathematical Curiosities and Hoard of Mathematical Treasures, Professor Stewart's brand-new book is a miscellany of over 150 mathematical curios and conundrums, packed with trademark humour and numerous illustrations. In addition to the fascinating formulae and thrilling theorems familiar to Professor Stewart's fans, the Casebook follows the adventures of the not-so-great detective Hemlock Soames and his sidekick Dr John Watsup (immortalised in the phrase 'Watsup, Doc?'). By a remarkable coincidence they live at 222B Baker Street, just a

  10. Racist appearance standards and the enhancements that love them: Norman Daniels and skin-lightening cosmetics.

    Science.gov (United States)

    Lamkin, Matt

    2011-05-01

    Darker skin correlates with reduced opportunities and negative health outcomes. Recent discoveries related to the genes associated with skin tone, and the historical use of cosmetics to conform to racist appearance standards, suggest effective skin-lightening products may soon become available. This article examines whether medical interventions of this sort should be permitted, subsidized, or restricted, using Norman Daniels's framework for determining what justice requires in terms of protecting health. I argue that Daniels's expansive view of the requirements of justice in meeting health needs offers some support for recognizing a societal obligation to provide this kind of 'enhancement,' in light of the strong connections between skin tone and health outcomes. On balance, however, Daniels's framework offers compelling reasons to reject insurance coverage for skin-lightening medical interventions, including the likely ineffectiveness of such technologies in mitigating racial health disparities, and the danger that covering skin-lightening enhancements would undermine public support for cooperative schemes that protect health. In fact, justice may require limiting access to these technologies because of their potential to exacerbate the negative effects of racism. © 2009 Blackwell Publishing Ltd.

  11. Elaborating Naturalized Critical Realism: Response to Ruth Groff, Dave Elder-Vass, Daniel Little and Petri Ylikoski

    Directory of Open Access Journals (Sweden)

    Kaidesoja Tuukka

    2015-09-01

    Full Text Available This paper is a reply to the discussions of Ruth Groff, Dave Elder-Vass, Daniel Little, and Petri Ylikoski of Tuukka Kaidesoja (2013: Naturalizing Critical Realist Social Ontology (London: Routledge.

  12. Kultuuri ei saa uurida vaakumis / Rebekka Lotman, Daniele Monticelli, Marek Tamm, Rein Raud ; intervjueerinud Valle-Sten Maiste

    Index Scriptorium Estoniae

    Lotman, Rebekka, 1978-

    2016-01-01

    100 raamatuni jõudnud Tallinna Ülikooli Kirjastus on püüdnud Eestis juurutada teaduskirjastamise rahvusvahelisi standardeid. Vestlusringis Rebekka Lotman, Daniele Monticelli, Marek Tamm ja Rein Raud

  13. Kai Adolf Jensen, professor i almindelig patologi

    DEFF Research Database (Denmark)

    Høiby, Niels

    2016-01-01

    for the Bacillus Calmette-Guérin vaccine production and supervised many young scientists’ doctoral theses on the aspects of tuberculosis. He became internationally recognized, and he revealed an important scientific fraud in the laboratory of the Austrian professor Ernst Löwenstein (1878-1950), who claimed that he...

  14. String theorist takes over as Lucasian Professor

    Science.gov (United States)

    Banks, Michael

    2009-11-01

    String theorist Michael Green will be the next Lucasian Professor of Mathematics at Cambridge University. Green, 63, will succeed Stephen Hawking, who held the chair from 1980 before retiring last month at the age of 67 and taking up a distinguished research chair at the Perimeter Institute for Theoretical Physics in Canada (see above).

  15. Epistemology Shock: English Professors Confront Science

    Science.gov (United States)

    Barnard, Ian; Osborn, Jan

    2017-01-01

    This article raises questions and concerns regarding students from the sciences working with faculty in the humanities in interdisciplinary settings. It explores the experience of two English professors facing the privileging of "facts" and a science-based understanding of the world in their own classrooms. It poses both questions and…

  16. Understanding Asperger Syndrome: A Professor's Guide [DVD

    Science.gov (United States)

    Organization for Autism Research (NJ3), 2011

    2011-01-01

    College can be a trying time in any individual's life. For adults with Asperger Syndrome this experience can be overwhelming. This title in the new DVD series Asperger Syndrome and Adulthood focuses on educating professors, teaching assistants, and others on what it means to be a college student on the spectrum and how they might best be able to…

  17. Professor Brand Advocacy: Do Brand Relationships Matter?

    Science.gov (United States)

    Jillapalli, Ravi K.; Wilcox, James B.

    2010-01-01

    The trend among students to advocate their professors online continues to generate interest within marketing academia. Brand advocacy in products and services has played a vital role in marketing. However, no known research to date has embraced the idea of brand advocacy in marketing education. This research builds on the recent human brand…

  18. Forestry professors and students receive national recognition

    OpenAIRE

    Davis, Lynn

    2005-01-01

    Two Virginia Tech professors in the College of Natural Resources and the university's Society of American Foresters student chapter received awards for their accomplishments at the Society of American Foresters 2005 national convention held in Fort Worth, Texas, earlier this month.

  19. Two business professors receive Fulbright Scholar awards

    OpenAIRE

    Ho, Sookhan

    2005-01-01

    Virginia Tech Pamplin College of Business professors Larry French and Mahmood A. Khan have received Fulbright Scholar Awards to teach and conduct research abroad next year. Both faculty members teach in the MBA program at the university's Northern Virginia Center in metro Washington, D.C.

  20. The Supervisor Is Not the Professor

    Science.gov (United States)

    Johnson, G. Stewart; Shafer, Carl

    1970-01-01

    College educational exposure does not prepare the graduate for the human relations demands of teamwork in industry, and may not prepare the graduate for the relationship with his supervisor. Five major dimensions of difference for the student between his interaction with his professors and his new relationships with his supervisor are: degree of…

  1. "Dear Professor: I Hate You"--Anonymous

    Science.gov (United States)

    Bartlett, Thomas

    2009-01-01

    Flip through a stack of anonymous student evaluations of professors and the mild comments, even the compliments, tend to blend together. But often, hidden among them, is a dagger. Then there are the out-and-out insults. Students' comments can be more than simply mean. Sometimes student comments aren't cruel, just weird. In this article, some…

  2. Africa's New Crisis: A Dearth of Professors

    Science.gov (United States)

    Lindow, Megan

    2009-01-01

    With many professors approaching retirement. a shortage of qualified academics has reached crisis proportions at a number of African universities. The shortfall is a consequence of decades of neglect of African higher education, as donors and governments concentrated limited resources on primary and secondary schools, and young scholars who manage…

  3. Professor Jacques Cortes prantsuse keele lektoraadis

    Index Scriptorium Estoniae

    2000-01-01

    Juuni alguses külastas filoloogiateaduskonna romaani-germaani filoloogia osakonda Roueni ülikooli professor Jacques Cortes (Prantsusmaa). Ta korraldas 4. õa üliõpilastele prantsuse keele intensiivkursuse ja võttis vastu eksami ning kohtus prantsuse keele lektoraadi õppejõududega : [täistekst

  4. Microcomputing Competencies for Special Education Professors.

    Science.gov (United States)

    Blackhurst, A. Edward; And Others

    1987-01-01

    A list of microcomputing competencies associated with functions that special education professors typically perform was assessed by 148 special education faculty who use microcomputers. Word processing was rated as the single most useful competency, along with the category of providing instruction about microcomputer applications in special…

  5. Veterinary medicine professor receives national honor

    OpenAIRE

    Douglas, Jeffrey S.

    2005-01-01

    Marie-Suthers-McCabe, of Riner, Va., associate professor of small animal clinical sciences at the Virginia-Maryland Regional College of Veterinary Medicine, has been awarded the highest honor in the nation for work in the area of the "human/animal bond."

  6. CFA or CFP: A Guide for Professors

    Science.gov (United States)

    Moy, Ronald L.

    2011-01-01

    The CFA Institute and the CFP Board of Standards provide professional certifications in the field of finance. In this paper, I provide my experience with the CFA and CFP programs in order to give other professors some insight into the process of attaining the designations. I hope to provide answers to some of the questions that other faculty…

  7. Family Law and Family Studies: Professor's Views

    Science.gov (United States)

    Hicks, Mary W.; And Others

    1977-01-01

    The results of a survey of family studies faculty concerning the inclusion of family law topics in family studies courses are discussed. The professor's needs for training and resources in the area of family and the law are identified and recommendations for meeting these needs are suggested. (Author)

  8. Survival quantitative trait locus fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium.

    Science.gov (United States)

    Casellas, J

    2007-05-01

    I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on chi(2)-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals.

  9. Professor Attitudes and Beliefs about Teaching Evolution

    Science.gov (United States)

    Barnes, Maryann Elizabeth

    Teaching evolution has been shown to be a challenge for faculty, in both K-12 and postsecondary education. Many of these challenges stem from perceived conflicts not only between religion and evolution, but also faculty beliefs about religion, it's compatibility with evolutionary theory, and it's proper role in classroom curriculum. Studies suggest that if educators engage with students' religious beliefs and identity, this may help students have positive attitudes towards evolution. The aim of this study was to reveal attitudes and beliefs professors have about addressing religion and providing religious scientist role models to students when teaching evolution. 15 semi-structured interviews of tenured biology professors were conducted at a large Midwestern universiy regarding their beliefs, experiences, and strategies teaching evolution and particularly, their willingness to address religion in a class section on evolution. Following a qualitative analysis of transcripts, professors did not agree on whether or not it is their job to help students accept evolution (although the majority said it is not), nor did they agree on a definition of "acceptance of evolution". Professors are willing to engage in students' religious beliefs, if this would help their students accept evolution. Finally, professors perceived many challenges to engaging students' religious beliefs in a science classroom such as the appropriateness of the material for a science class, large class sizes, and time constraints. Given the results of this study, the author concludes that instructors must come to a consensus about their goals as biology educators as well as what "acceptance of evolution" means, before they can realistically apply the engagement of student's religious beliefs and identity as an educational strategy.

  10. A shrinkage method for testing the Hardy-Weinberg equilibrium in case-control studies.

    Science.gov (United States)

    Zang, Yong; Yuan, Ying

    2013-11-01

    Testing for the Hardy-Weinberg equilibrium (HWE) is often used as an initial step for checking the quality of genotyping. When testing the HWE for case-control data, the impact of a potential genetic association between the marker and the disease must be controlled for otherwise the results may be biased. Li and Li [2008] proposed a likelihood ratio test (LRT) that accounts for this potential genetic association and it is more powerful than the commonly used control-only χ² test. However, the LRT is not efficient when the marker is independent of the disease, and also requires numerical optimization to calculate the test statistic. In this article, we propose a novel shrinkage test for assessing the HWE. The proposed shrinkage test yields higher statistical power than the LRT when the marker is independent of or weakly associated with the disease, and converges to the LRT when the marker is strongly associated with the disease. In addition, the proposed shrinkage test has a closed form and can be easily used to test the HWE for large datasets that result from genome-wide association studies. We compare the performance of the shrinkage test with existing methods using simulation studies, and apply the shrinkage test to a genome-wide association dataset for Alzheimer's disease. © 2013 WILEY PERIODICALS, INC.

  11. Weinberg sum rules and the parity doubling of radial Regge trajectories

    Energy Technology Data Exchange (ETDEWEB)

    Andrianov, A.A. [Departament d' Estructura i Constituents de la Materia and ICCUB, Institut de Ciencies del Cosmos, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain)], E-mail: andrianov@ecm.ub.es; Espriu, D. [Departament d' Estructura i Constituents de la Materia and ICCUB, Institut de Ciencies del Cosmos, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain)], E-mail: espriu@ecm.ub.es

    2009-01-19

    Assuming that the radial excitations of q-barq meson states exactly follow linear Regge trajectories with constant residues, as prescribed by dual models, and using large N{sub c} arguments and the matching to perturbative QCD in the deep-Minkowski region we obtain that: (a) the region dominated by resonances and the one saturated by perturbation theory approach each other as N{sub c} increases; (b) the scales {lambda}{sup (V,A)} separating the resonance-dominated and the perturbative-saturated region in the V,A channels, respectively, grow as {radical}(N{sub c}), whereas the difference between ({lambda}{sup V}){sup 2} and ({lambda}{sup A}){sup 2} stays constant or even decreases as N{sub c} increases; (c) the number of visible resonances increases as N{sub c}; (d) in order to satisfy the Weinberg sum rules the slopes of Regge trajectories for mesons of opposite parities must coincide, but the intercepts may differ by a quantity of O(1) at most in the large N{sub c} limit. This suggests that modelizations of QCD where these characteristics are not present and yet the resonances follow linear Regge trajectories are not compatible with the symmetries or short-distance properties of QCD.

  12. Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Vine, Anna E; Curtis, David

    2009-03-02

    Deviations from Hardy-Weinberg equilibrium (HWE) are commonly thought of as indicating genotyping errors, population stratification or some other artefact. However they could also arise through important biological mechanisms. In particular, genetic variants having a recessive effect on the successful fertilisation and/or development of an embryo might be manifest through such deviations in an unselected sample of "control" subjects. We investigated genotypes from 463842 autosomal markers from 1504 British subjects. We identified regions in which several neighbouring markers exhibited deviation from HWE in the same direction by considering "heterozygosity scores" in windows of 10 markers. The heterozygosity score for each marker was defined as -log(p) or log(p) according to whether the marker demonstrated increased heterozygosity or homozygosity. In each window the marker with the highest absolute score was ignored and the positive and negative scores were summed for the other nine markers. Windows were selected on the basis of this sum exceeding a given threshold, for which we used values of 50 or 15.For the threshold of 50, we identified 7 regions with increased heterozygosity and for the threshold of 15 we identified 22 regions with increased heterozygosity, 23 with increased homozygosity and 2 containing both kinds of window. The most impressive of these results came from a group of 6 markers at 17q21, each of which showed increased heterozygosity significant at p < 10(-190). The human genome contains regions which deviate markedly from HWE and these might harbour genes influencing embryonic survival.

  13. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies.

    Science.gov (United States)

    Rodriguez, Santiago; Gaunt, Tom R; Day, Ian N M

    2009-02-15

    Mendelian randomization (MR) permits causal inference between exposures and a disease. It can be compared with randomized controlled trials. Whereas in a randomized controlled trial the randomization occurs at entry into the trial, in MR the randomization occurs during gamete formation and conception. Several factors, including time since conception and sampling variation, are relevant to the interpretation of an MR test. Particularly important is consideration of the "missingness" of genotypes that can be originated by chance, genotyping errors, or clinical ascertainment. Testing for Hardy-Weinberg equilibrium (HWE) is a genetic approach that permits evaluation of missingness. In this paper, the authors demonstrate evidence of nonconformity with HWE in real data. They also perform simulations to characterize the sensitivity of HWE tests to missingness. Unresolved missingness could lead to a false rejection of causality in an MR investigation of trait-disease association. These results indicate that large-scale studies, very high quality genotyping data, and detailed knowledge of the life-course genetics of the alleles/genotypes studied will largely mitigate this risk. The authors also present a Web program (http://www.oege.org/software/hwe-mr-calc.shtml) for estimating possible missingness and an approach to evaluating missingness under different genetic models.

  14. An incomplete enumeration algorithm for an exact test of Hardy-Weinberg proportions with multiple alleles.

    Science.gov (United States)

    Maurer, H P; Melchinger, A E; Frisch, M

    2007-08-01

    Testing of Hardy-Weinberg proportions (HWP) with asymptotic goodness-of-fit tests is problematic when the contingency table of observed genotype counts has sparse cells or the sample size is low, and exact procedures are to be preferred. Exact p-values can be (1) calculated via computational demanding enumeration methods or (2) approximated via simulation methods. Our objective was to develop a new algorithm for exact tests of HWP with multiple alleles on the basis of conditional probabilities of genotype arrays, which is faster than existing algorithms. We derived an algorithm for calculating the exact permutation significance value without enumerating all genotype arrays having the same allele counts as the observed one. The algorithm can be used for testing HWP by (1) summation of the conditional probabilities of occurrence of genotype arrays with smaller probability than the observed one, and (2) comparison of the sum with a nominal Type I error rate alpha. Application to published experimental data from seven maize populations showed that the exact test is computationally feasible and reduces the number of enumerated genotype count matrices about 30% compared with previously published algorithms.

  15. A confidence-limit-based approach to the assessment of Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Wellek, Stefan; Goddard, Katrina A B; Ziegler, Andreas

    2010-04-01

    The classical chi(2)-procedure for the assessment of Hardy-Weinberg equilibrium (HWE) is tailored for detecting violations of HWE. However, many applications in genetic epidemiology require approximate compatibility with HWE. In a previous contribution to the field (Wellek, S. (2004). Biometrics, 60, 694-703), the methodology of statistical equivalence testing was exploited for the construction of tests for problems in which the assumption of approximate compatibility of a given genotype distribution with HWE plays the role of the alternative hypothesis one aims to establish. In this article, we propose a procedure serving the same purpose but relying on confidence limits rather than critical bounds of a significance test. Interval estimation relates to essentially the same parametric function that was previously chosen as the target parameter for constructing an exact conditional UMPU test for equivalence with a HWE conforming genotype distribution. This population parameter is shown to have a direct genetic interpretation as a measure of relative excess heterozygosity. Confidence limits are constructed using both asymptotic and exact methods. The new approach is illustrated by reanalyzing genotype distributions obtained from published genetic association studies, and detailed guidance for choosing the equivalence margin is provided. The methods have been implemented in freely available SAS macros.

  16. Testing Hardy-Weinberg equilibrium using family data from complex surveys.

    Science.gov (United States)

    She, Dewei; Zhang, Hong; Li, Zhaohai

    2009-07-01

    Genetic data collected during the second phase of the Third National Health and Nutrition Examination Survey (NHANES III) enable us to investigate the association of a wide variety of health factors with regard to genetic variation. The classic question when looking into the genetic variations in a population is whether the population is in the state of Hardy-Weinberg Equilibrium (HWE). Our objective was to develop test procedures using family data from complex surveys such as NHANES III. We developed six Pearson chi(2) based tests for a diallelic locus of autosomal genes. The finite sample properties of the proposed test procedures were evaluated via Monte Carlo simulation studies and the Rao-Scott first order corrected test was recommended. Test procedures were applied to three loci from NHANES III genetic databases, i.e., ADRB2, TGFB1, and VDR. HWE was shown to hold at 0.05 level for all three loci when only families with genotypic information available for two parents and for one or more children were used in the analysis.

  17. Approximate and exact tests of Hardy-Weinberg equilibrium using uncertain genotypes.

    Science.gov (United States)

    Shriner, Daniel

    2011-11-01

    Testing for Hardy-Weinberg equilibrium (HWE) is commonly used as a quality control filter in genome-wide scans for markers with experimentally determined genotypes. In contrast, for markers with imputed genotypes, there are post-imputation metrics of quality that can be used as screens but there are no formal tests of deviation from HWE. Similarly, there are no formal tests of deviation from HWE for probabilistic genotypes that are generated by sequencing projects. Here, I describe generalizations of the approximate χ(2) and exact tests of HWE for use with uncertain genotypes. The tests fully account for the probabilities of all possible genotypes at a marker for each individual. By computer simulation, the approximate and exact tests are shown to maintain valid control of the type I error rate. Calculations of the loss of power as the uncertainty in genotypes increases are illustrated. The tests are compatible with chip-based genotypes for single-nucleotide polymorphisms and copy number polymorphisms, imputed genotypes, and probabilistic assignments of genotype from variable-coverage sequence data. © 2011 Wiley Periodicals, Inc.

  18. The mid p-value in exact tests for Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Graffelman, Jan; Moreno, Victor

    2013-08-01

    Exact tests for Hardy-Weinberg equilibrium are widely used in genetic association studies. We evaluate the mid p-value, unknown in the genetics literature, as an alternative for the standard p-value in the exact test. The type 1 error rate and the power of the exact test are calculated for different sample sizes, significance levels, minor allele counts and degrees of deviation from equilibrium. Three different p-value are considered: the standard two-sided p-value, the doubled one-sided p-value and the mid p-value. Practical implications of using the mid p-value are discussed with HapMap datasets and a data set on colon cancer. The mid p-value is shown to have a type 1 error rate that is always closer to the nominal level, and to have better power. Differences between the standard p-value and the mid p-value can be large for insignificant results, and are smaller for significant results. The analysis of empirical databases shows that the mid p-value uncovers more significant markers, and that the equilibrium null distribution is not tenable for both databases. The standard exact p-value is overly conservative, in particular for small minor allele frequencies. The mid p-value ameliorates this problem by bringing the rejection rate closer to the nominal level, at the price of occasionally exceeding the nominal level.

  19. A straightforward multiallelic significance test for the Hardy-Weinberg equilibrium law.

    Science.gov (United States)

    Lauretto, Marcelo S; Nakano, Fabio; Faria, Silvio R; Pereira, Carlos A B; Stern, Julio M

    2009-07-01

    Much forensic inference based upon DNA evidence is made assuming Hardy-Weinberg Equilibrium (HWE) for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, and their limitations become more obvious when testing for deviation within multiallelic DNA loci. The most popular methods-Chi-square and Likelihood-ratio tests-are based on asymptotic results and cannot guarantee a good performance in the presence of low frequency genotypes. Since the parameter space dimension increases at a quadratic rate on the number of alleles, some authors suggest applying sequential methods, where the multiallelic case is reformulated as a sequence of "biallelic" tests. However, in this approach it is not obvious how to assess the general evidence of the original hypothesis; nor is it clear how to establish the significance level for its acceptance/rejection. In this work, we introduce a straightforward method for the multiallelic HWE test, which overcomes the aforementioned issues of sequential methods. The core theory for the proposed method is given by the Full Bayesian Significance Test (FBST), an intuitive Bayesian approach which does not assign positive probabilities to zero measure sets when testing sharp hypotheses. We compare FBST performance to Chi-square, Likelihood-ratio and Markov chain tests, in three numerical experiments. The results suggest that FBST is a robust and high performance method for the HWE test, even in the presence of several alleles and small sample sizes.

  20. A note on exact conditional and unconditional tests for Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Shan, Guogen

    2013-01-01

    The exact conditional approach is frequently used for testing Hardy-Weinberg equilibrium in population genetics. This approach respects the test size as compared to the traditionally used asymptotic approaches. It is a full-enumeration method and very computational. Many efficient algorithms have been successfully developed to implement this exact approach. An alternative to the conditional approach is the unconditional approach, which relaxes the restriction of the fixed number of allelic counts as in the conditional approach. The first unconditional test considered in this study is the one based on maximization, which has been shown to be more powerful than the conditional test to loci with two alleles for small sample sizes. By using the p value of the conditional approach as a test statistic in the following maximization step, the second unconditional test is uniformly more powerful than the conditional approach. We compared these exact tests based on three commonly used test statistics with regards to type I error rate and power. It is recommended to use the second unconditional approach in practice due to the power gain in the case with two alleles.

  1. The use of Hardy-Weinberg Equilibrium in clonal plant systems.

    Science.gov (United States)

    Douhovnikoff, Vladimir; Leventhal, Matthew

    2016-02-01

    Traditionally population genetics precludes the use of the same genetic individual more than once in Hardy-Weinberg (HW) based calculations due to the model's explicit assumptions. However, when applied to clonal plant populations this can be difficult to do, and in some circumstances, it may be ecologically informative to use the ramet as the data unit. In fact, ecologists have varied the definition of the individual from a strict adherence to a single data point per genotype to a more inclusive approach of one data point per ramet. With the advent of molecular tools, the list of facultatively clonal plants and the recognition of their ecological relevance grows. There is an important risk of misinterpretation when HW calculations are applied to a clonal plant not recognized as clonal, as well as when the definition of the individual for those calculations is not clearly stated in a known clonal species. Focusing on heterozygosity values, we investigate cases that demonstrate the extreme range of potential modeling outcomes and describe the different contexts where a particular definition could better meet ecological modeling goals. We emphasize that the HW model can be ecologically relevant when applied to clonal plants, but caution is necessary in how it is used, reported, and interpreted. We propose that in known clonal plants, both genotype (GHet) and ramet (RHet) based calculations are reported to define the full range of potential values and better facilitate cross-study comparisons.

  2. Assessing departure from Hardy-Weinberg equilibrium in the presence of disease association.

    Science.gov (United States)

    Li, Mingyao; Li, Chun

    2008-11-01

    Assessing Hardy-Weinberg equilibrium (HWE) is often employed as an important initial step for genotype data quality checking in genetics studies. Tests for HWE often assume that the genotypes are randomly sampled from the general population. However, in many human genetics studies, subjects are ascertained through their disease status, and affected individuals (and their relatives in family-based studies) are overly represented in the ascertained sample than in the general population. As a result, when a marker is associated with the disease, the type I error rate in the HWE tests can be inflated, leading to false exclusion of associated markers from future analysis. Here we develop a general likelihood framework that allows assessment of departure from HWE while taking into account potential association with the disease. Our method can differentiate HWE departure caused by disease association from departure caused by other reasons, such as genotyping errors. The framework can be used for various data structures, including unrelated cases and controls, nuclear families with one or more offspring, or a mixture of them. The type I error rate of our test is under control for a broad range of scenarios. For case-control data, compared to the traditional HWE test that uses only controls, our test is more powerful to detect HWE departure for common diseases and has comparable power for rare diseases. For case-parents trios, our test is more powerful than the traditional HWE test that uses parents only.

  3. Fitting Proportional Odds Model to Case-Control data with Incorporating Hardy-Weinberg Equilibrium.

    Science.gov (United States)

    Zhang, Wei; Zhang, Zehui; Li, Xinmin; Li, Qizhai

    2015-11-26

    Genetic association studies have been proved to be an efficient tool to reveal the aetiology of many human complex diseases and traits. When the phenotype is binary, the logistic regression model is commonly employed to evaluate the association strength of the genetic variants predispose to human diseases because the maximum likelihood estimator of the odds ratio based on case-control data is equivalent to that from the same model by taking the data as being arisen prospectively. This equivalence does not hold for the proportional odds model and using it to analyze the case-control data directly often results in a substantial bias. Through putting a parameter of the minor allele frequency in the modified likelihood function under the condition that the Hardy-Weinberg equilibrium law holds within controls, a consistent estimator is obtained. On the basis of it, we construct a score test statistic to test whether the genetic variant is associated with the diseases. Simulation studies show that the proposed estimator has smaller mean squared error than the existing methods when the genetic effect size is away from zero and the proposed test statistic has a good control of type I error rate and is more powerful than the existing procedures. Application to 45 single nucleotide polymorphisms located in the region of TRAF1-C5 genes for the association with four-level anticyclic citrullinated protein antibody from Genetic Analysis Workshop 16 further demonstrates its performance.

  4. Testing for Hardy-Weinberg equilibrium at biallelic genetic markers on the X chromosome.

    Science.gov (United States)

    Graffelman, J; Weir, B S

    2016-06-01

    Testing genetic markers for Hardy-Weinberg equilibrium (HWE) is an important tool for detecting genotyping errors in large-scale genotyping studies. For markers at the X chromosome, typically the χ(2) or exact test is applied to the females only, and the hemizygous males are considered to be uninformative. In this paper we show that the males are relevant, because a difference in allele frequency between males and females may indicate HWE not to hold. The testing of markers on the X chromosome has received little attention, and in this paper we lay down the foundation for testing biallelic X-chromosomal markers for HWE. We develop four frequentist statistical test procedures for X-linked markers that take both males and females into account: the χ(2) test, likelihood ratio test, exact test and permutation test. Exact tests that include males are shown to have a better Type I error rate. Empirical data from the GENEVA project on venous thromboembolism is used to illustrate the proposed tests. Results obtained with the new tests differ substantially from tests that are based on female genotype counts only. The new tests detect differences in allele frequencies and seem able to uncover additional genotyping error that would have gone unnoticed in HWE tests based on females only.

  5. Testing for Hardy-Weinberg proportions: have we lost the plot?

    Science.gov (United States)

    Waples, Robin S

    2015-01-01

    Testing for Hardy-Weinberg proportions (HWP) is routine in almost all genetic studies of natural populations, but many researchers do not demonstrate a full understanding of the purposes of these tests or how to interpret the results. Common problems include a lack of understanding of statistical power and the difference between statistical significance and biological significance, how to interpret results of multiple tests, and how to distinguish between various factors that can cause statistically significant departures. In this perspective, which focuses on analysis of genetic data for nonmodel species, I 1) review factors that can cause departures from HWP at individual loci and linkage disequilibrium (LD) at pairs of loci; 2) discuss commonly used tests for HWP and LD, with an emphasis on multiple-testing issues; 3) show how to distinguish among possible causes of departures from HWP; and 4) outline some simple steps to follow when significant test results are found. Finally, I 5) identify some issues that merit particular attention as we move into an era in which analysis of genomics-scale datasets for nonmodel species is commonplace. Published by Oxford University Press on behalf of the American Genetic Association 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  6. Attributing Hardy-Weinberg disequilibrium to population stratification and genetic association in case-control studies.

    Science.gov (United States)

    Grover, Vaneeta K; Cole, David E C; Hamilton, David C

    2010-01-01

    Loci exhibiting Hardy-Weinberg disequilibrium (HWD) are often excluded from association studies, because HWD may indicate genotyping error, population stratification or selection bias. For case-control studies, HWD can result from a genetic effect at the locus. We extend the modelling to accommodate both stratification and genetic effects. Theoretical genotype frequencies and HWD coefficients are derived under a general genetic model for a population with two strata. Maximum likelihood is used to estimate model parameters and a test for lack of fit identifies the models most consistent with the data. Simulations were used to assess the method. The technique was applied to a group of ethnically and clinically heterogeneous kidney stone formers and controls, both exhibiting HWD for the R990G SNP of the CASR gene. Results indicate the best fitting model incorporates both stratification and genetic association. The ability of our method to apportion HWD to stratification and genetic effects may well be a significant advance in dealing with heterogeneity in case-control genetic association studies.

  7. Testing Hardy-Weinberg equilibrium using mother-child case-control samples.

    Science.gov (United States)

    Chen, Jinbo; Zheng, Haitao; Wilson, Melissa L; Kraft, Peter

    2009-09-01

    Genetic association studies of obstetric complications may genotype case and control mothers, or their respective newborns, or both case-control mothers and their children. The relatively high prevalence of many obstetric complications and the availability of both maternal and offspring's genotype data have provided motivation to study new methods for testing for deviations from Hardy-Weinberg equilibrium (HWE). We propose four novel test statistics, each of which uses a different type of data as follows: (1) a test using maternal case-control genotype data, (2) a test using offspring genotype data, (3) a combination of the first and second tests, and (4) a test based on the joint classification of case-control maternal-child genotype data. The selection of case and control mothers (and thus their children) is accounted for by weighting both maternal and child contributions to the test statistics with sampling probabilities. Our tests thus do not require that the phenotype be rare as is the case for HWE tests using only controls, and are particularly suitable for genetic association studies of relatively common complications such as premature birth. The third and fourth tests described above utilize both maternal and child genotype data and appropriately account for the correlation between maternal and child genotypes. On the basis of extensive simulation studies to compare the type-I error and power for proposed tests, we recommend the third combined test statistic for routine use in the analysis of case-control studies of mother-child pairs.

  8. Incorporating Hardy-Weinberg Equilibrium Law to Enhance the Association Strength for Ordinal Trait Genetic Study.

    Science.gov (United States)

    Zhang, Wei; Li, Qizhai

    2016-03-01

    The conventional method to examine whether genetic variants are associated with the ordinal traits is the proportional odds model. Such analyses are often conducted by assuming an additive genetic mode of inheritance. However, how the genetic variants influence the risk of occurrence of a disease is impossible to know in practice. Using an improper model might result in a low-power test, thus it reduces the probability of detecting the deleterious genetic markers. To address these concerns, we propose a two-phase procedure (TPP) for ordinal trait genetic studies. In the first phase, we used a linear combination to weight the Hardy-Weinberg equilibrium tests in case groups and formed an omnibus test to classify the genetic models. Then based on the chosen model, the corresponding score test was used to identify the associations. To control the false positive rate, we derived the joint distribution of the test used for selecting the genetic model and that used for identifying the associations. We also obtained the closed forms of two other robust tests, MAX3 and CHI2. Extensive computer simulations were carried out and the results showed that the true selection rates of genetic models are satisfactory and the proposed TPP is more robust than MAX3 and CHI2. Finally, we demonstrated the advantage of our proposed method by applying it to analyse the antibody reactivity to cyclic citrullinated peptides data. © 2015 John Wiley & Sons Ltd/University College London.

  9. Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium.

    Science.gov (United States)

    Attia, John; Thakkinstian, Ammarin; McElduff, Patrick; Milne, Elizabeth; Dawson, Somer; Scott, Rodney J; Klerk, Nicholas de; Armstrong, Bruce; Thompson, John

    2010-01-01

    Tests for Hardy-Weinberg equilibrium (HWE) have been used to detect genotyping error, but those tests have low power unless the sample size is very large. We assessed the performance of measures of departure from HWE as an alternative way of screening for genotyping error. Three measures of the degree of disequilibrium (alpha, ,D, and F) were tested for their ability to detect genotyping error of 5% or more using simulations and a real dataset of 184 children with leukemia genotyped at 28 single nucleotide polymorphisms. The simulations indicate that all three disequilibrium coefficients can usefully detect genotyping error as judged by the area under the Receiver Operator Characteristic (ROC) curve. Their discriminative ability increases as the error rate increases, and is greater if the genotyping error is in the direction of the minor allele. Optimal thresholds for detecting genotyping error vary for different allele frequencies and patterns of genotyping error but allele frequency-specific thresholds can be nominated. Applying these thresholds would have picked up about 90% of genotyping errors in our actual dataset. Measures of departure from HWE may be useful for detecting genotyping error, but this needs to be confirmed in other real datasets.

  10. A comparison of tests for Hardy-Weinberg Equilibrium in national genetic household surveys.

    Science.gov (United States)

    Li, Yan

    2013-03-01

    This study is motivated by National Household Surveys that collect genetic data, in which complex samples (e.g. stratified multistage cluster sample), partially from the same family, are selected. In addition to the differential selection probabilities of selecting households and persons within the sampled households, there are two levels of correlations of the collected genetic data in National Genetic Household Surveys (NGHS). The first level of correlation is induced by the hierarchical geographic clustered sampling of households and the second level of correlation is induced by biological inheritances from individuals sampled in the same household. To test for Hardy-Weinberg Equilibrium (HWE) in NGHS, two test statistics, the CCS method [1] and the QS method [2], appear to be the only existing methods that take account of both correlations. In this paper, I evaluate both methods in terms of the test size and power under a variety of complex designs with different weighting schemes and varying magnitudes of the two correlation effects. Both methods are applied to a real data example from the Hispanic Health and Nutrition Examination Survey with simulated genotype data. The QS method maintains the nominal size well and consistently achieves higher power than the CCS method in testing HWE under a variety of sample designs, and therefore is recommended for testing HWE of genetic survey data with complex designs.

  11. A straightforward multiallelic significance test for the Hardy-Weinberg equilibrium law

    Directory of Open Access Journals (Sweden)

    Marcelo S. Lauretto

    2009-01-01

    Full Text Available Much forensic inference based upon DNA evidence is made assuming Hardy-Weinberg Equilibrium (HWE for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, and their limitations become more obvious when testing for deviation within multiallelic DNA loci. The most popular methods-Chi-square and Likelihood-ratio tests-are based on asymptotic results and cannot guarantee a good performance in the presence of low frequency genotypes. Since the parameter space dimension increases at a quadratic rate on the number of alleles, some authors suggest applying sequential methods, where the multiallelic case is reformulated as a sequence of "biallelic" tests. However, in this approach it is not obvious how to assess the general evidence of the original hypothesis; nor is it clear how to establish the significance level for its acceptance/rejection. In this work, we introduce a straightforward method for the multiallelic HWE test, which overcomes the aforementioned issues of sequential methods. The core theory for the proposed method is given by the Full Bayesian Significance Test (FBST, an intuitive Bayesian approach which does not assign positive probabilities to zero measure sets when testing sharp hypotheses. We compare FBST performance to Chi-square, Likelihood-ratio and Markov chain tests, in three numerical experiments. The results suggest that FBST is a robust and high performance method for the HWE test, even in the presence of several alleles and small sample sizes.

  12. Daniel Hugo

    African Journals Online (AJOL)

    Owner

    toon skerper en selfs meer inborend: “hierdie land is klaar met God:/ êrens suid is sy Vinger vergruis/ en by Twyfelfontein/ lê brokstukke van sy Vuis” (29) skryf hy van Namibië; die digter “soek na God se gesonke oog” (12); die. Moslem-imam sê “Allah het ons gevaarlik lief ” en die digter dink “Met nog 'n aardbewing sal.

  13. Daniel Jones

    DEFF Research Database (Denmark)

    from the original phonetic transcription to the conventional orthography). Much unpublished work, ranging from lecture notes on the sound systems of French, Spanish and Italian, to hitherto unpublished details of Jones' dealings with celebrities such as George Bernard Shaw and the Poet Laureate Robert...

  14. Daniel Gogny

    Energy Technology Data Exchange (ETDEWEB)

    Berger, J.F.; Bouche, D.; Delaroche, J.P.; Dupuis, M.; Girod, M.; Pillet, N. [CEA, DAM, DIF, Arpajon (France); Blaizot, J.P.; Chaix, P.; Iracane, D.; Lachkar, J. [CEA, Saclay, Gif-sur-Yvette (France); Grammaticos, B. [CNRS, IMNC, Orsay (France); Mariotte, F. [CEA, Fontenay-aux-Roses (France); Van Giai, N. [Institut de Physique Nucleaire, CNRS-IN2P3 et Universite Paris-Sud, Orsay (France); Gogny, J.

    2017-10-15

    In this article, the scientific life of D. Gogny is recounted by several collaborators. His strong involvement in researches related to various fields of physics (such as nuclear, atomic and plasma physics as well as electromagnetism) appears clearly, as well as the progresses made in the understanding of fundamental physics. (orig.)

  15. Yuriko and Michael Renardy reappointed Class of 1950 Professors

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Yuriko and Michael Renardy, professors of mathematics in the College of Science at Virginia Tech, have been reappointed as the Virginia Tech Class of 1950 Professors by the Virginia Tech Board of Visitors.

  16. Categorization of Quantum Mechanics Problems by Professors and Students

    Science.gov (United States)

    Lin, Shih-Yin; Singh, Chandralekha

    2010-01-01

    We discuss the categorization of 20 quantum mechanics problems by physics professors and undergraduate students from two honours-level quantum mechanics courses. Professors and students were asked to categorize the problems based upon similarity of solution. We also had individual discussions with professors who categorized the problems. Faculty…

  17. E-Mail from Professor Enhances Student Motivation and Attitudes

    Science.gov (United States)

    Legg, Angela M.; Wilson, Janie H.

    2009-01-01

    Traditionally, professors use the first day of class to build rapport. However, current technology allows professors to contact students prior to the first day of class. This study assessed how the receipt of a welcoming e-mail from a female professor 1 week before the first day of class affected student motivation and attitudes toward the…

  18. Connect and Thrive: Perspectives from a Newly Tenured Professor

    Science.gov (United States)

    Ciocchetti, Corey A.

    2011-01-01

    This essay encapsulates the author's perspective on how average professors can become highly effective professors. The author asserts that the secret rests in the ability to genuinely connect with students. Connecting really matters--even if it takes some personality adaptation and thrusts academics out of their comfort zones. Many professors fail…

  19. Anti-Fat Bias by Professors Teaching Physical Education Majors

    Science.gov (United States)

    Fontana, Fabio; Furtado, Ovande, Jr.; Mazzardo, Oldemar, Jr.; Hong, Deockki; de Campos, Wagner

    2017-01-01

    Anti-fat bias by professors in physical education departments may interfere with the training provided to pre-service teachers. The purpose of this study was to evaluate the attitudes of professors in physical education departments toward obese individuals. Professors from randomly selected institutions across all four US regions participated in…

  20. 26 CFR 509.115 - Visiting professors or teachers.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Visiting professors or teachers. 509.115...) REGULATIONS UNDER TAX CONVENTIONS SWITZERLAND General Income Tax § 509.115 Visiting professors or teachers. (a) General. Pursuant to Article XII of the convention, a professor or teacher, a nonresident alien who is a...

  1. Variables That Can Affect Student Ratings of Their Professors

    Science.gov (United States)

    Gotlieb, Jerry

    2013-01-01

    Attribution theory was applied to help predict the results of an experiment that examined the effects of three independent variables on students' ratings of their professors. The dependent variables were students' perceptions of whether the professor caused the students' grades and student satisfaction with their professor. The results suggest…

  2. Learning to Think Slower: Review of Thinking, Fast and Slow by Daniel Kahneman (2011)

    OpenAIRE

    Samuel L. Tunstall; Patrick N. Beymer

    2017-01-01

    Daniel Kahneman. Thinking, Fast and Slow (New York, NY: Farrar, Straus and Giroux) 499 pp. ISBN 978-0374275631. As an expansive review of Kahneman and others' work over the past half-century in understanding human decision-making, Thinking, Fast and Slow provides Numeracy readers much to consider for both pedagogy and research. In this review, we outline Kahneman's core argument—that humans use both rash (emotional) System 1 thinking and slow (logical) System 2 thinking—then discuss how su...

  3. Daniel Augusto da Silva e o cálculo actuarial

    OpenAIRE

    Martins, Ana Patrícia Morais da Fonseca, 1978-

    2013-01-01

    Tese de doutoramento, História e Filosofia das Ciências, Universidade de Lisboa, Faculdade de Ciências, 2013 Daniel Augusto da Silva (1814-1878) é reconhecido como um dos mais importantes matemáticos portugueses do século XIX. O foco desta tese incide no seu contributo na área do Cálculo Actuarial, entre 1863 e 1871, especificamente, os seus estudos sobre a viabilidade de planos de pensões de montepios de sobrevivência. Numa época em que, em Portugal, os planos de pensões dessas sociedades...

  4. Dr. Renato Daniel Berrón Pérez (1934-2017

    Directory of Open Access Journals (Sweden)

    Francisco Javier Espinosa Rosales

    2017-06-01

    Full Text Available El Dr. Renato Daniel Berrón Pérez nació en la Ciudad de México el 17 de octubre de 1934. Todos los que estudiamos y trabajamos con él, sabíamos su edad porque que tenía la misma edad que “La Polar”, un famoso restaurante de Birria cerca de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional (ENCB-IPN, abierto en 1934 y al que le gustaba ir.

  5. Daniel R. ERNST. Lawyers against Labor : From Individual Rights to Corporate Liberalism.

    Directory of Open Access Journals (Sweden)

    Alexis Chommeloux

    2006-03-01

    Full Text Available The late nineteenth and early twentieth centuries was a period of considerable change in American labour relations, a change which is at the very heart of Daniel D. Ernst’s Lawyers against Labor. Economic changes were taking place with the decline of proprietary capitalism and the emergence, alongside the notion of “business trust,” of what embattled proprietary capitalists saw as an equally dangerous “labor trust.” The “age of the party” was coming to an end and being replaced by the “age of...

  6. Migration and New Media: Transnational Families and Polymedia by Mirca Madianou and Daniel Miller (Routledge, 2012

    Directory of Open Access Journals (Sweden)

    Erwin Gaspar A. Alampay

    2012-06-01

    Full Text Available In 2007, Daniel Miller presented his paper on “What is a Mobile PhoneRelationship” in the “1st Living the Information Society Conference” held inManila. In his presentation, he mentioned the work he was just embarking onwith Mirca Madianou on long-distance relationships of separated families andthe ability of different media to sustain those relationships over time (Miller,2009. He was then building on the extensive work that Parrenas (2001, 2005a,2005b had done on Filipino transnational families, and in particular, on motheringfrom a distance

  7. Learning to Think Slower: Review of Thinking, Fast and Slow by Daniel Kahneman (2011

    Directory of Open Access Journals (Sweden)

    Samuel L. Tunstall

    2017-07-01

    Full Text Available Daniel Kahneman. Thinking, Fast and Slow (New York, NY: Farrar, Straus and Giroux 499 pp. ISBN 978-0374275631. As an expansive review of Kahneman and others' work over the past half-century in understanding human decision-making, Thinking, Fast and Slow provides Numeracy readers much to consider for both pedagogy and research. In this review, we outline Kahneman's core argument—that humans use both rash (emotional System 1 thinking and slow (logical System 2 thinking—then discuss how such systems might be addressed in a quantitative literacy classroom.

  8. Daniel Vergara Lope and Carlos Monge Medrano: two pioneers of high altitude medicine.

    Science.gov (United States)

    Rodríguez de Romo, Ana Cecilia

    2002-01-01

    Daniel Vergara Lope from Mexico and Carlos Monge Medrano from Peru were brilliant scientists in their own countries. Both scientists studied high altitude physiology and defined the physiological and anatomical mechanisms of adaptation to high elevations. The Mexican physiologist proposed his ideas 40 years before his Peruvian counterpart. This paper studies the contribution of Vergara Lope and Monge Medrano to the understanding of high altitude medicine and proposes explanations of why history has given priority to Monge, whereas Vergara Lope is relegated to anonymity.

  9. Spotlight on CERN : Professor Michel Spiro

    CERN Multimedia

    CERN video productions

    2011-01-01

    20 Member states throughout Europe. A geographical expansion underway. A worldwide, international collaboration and a scientific challenge on a scale second to none. In view of this complexity, how is CERN managed? This is the remit of the CERN council, which notably defines the strategic programmes, annual objectives, approves the annual budget and nominates the directorate. I am pleased to welcome Professor Michel Spiro, scientific director of the CNRS in France and CERN Council presdient since 2010. On today’s agenda: Expansion, innovation and communication. Hello and welcome Professor.. François et Stéphan are of course with me today to discuss such matters as antimatter, press and we will also be talking water and towers… I will say no more. It’s good to see you both ! And welcome to you all for this latest edition of Spotlight on CERN.

  10. 31 July 2014 - Professor M. Kastner

    CERN Multimedia

    Egli, Laurent

    2014-01-01

    MIT Faculty Member Donner Professor of Physics Massachusetts Institute of Technology United States of America, Prof. M. Kastner visiting the LHC tunnel at Point 5 with Beams Department M. Solfaroli Camillocci, LHC superconducting magnet assembly hall visit with L. Rossi and R. Principe, LHC Computing Grid Project presentation and computer centre visit with I. Bird and signing the guest book with CERN Director-General R. Heuer.

  11. [Homage to Professor Dr. Nicasio Etchepareborda].

    Science.gov (United States)

    1998-11-01

    During a solemn academic act, de Main Classroom of the Facultad de Odontologia de Buenos Aires was named after Prof. Dr. Nicasio Etchepareborda. He has been the first professor at the Escuela de Odontologia and its organizer, after having obtained his Dentistry degree at the Dental School of Paris, in 1882. The new school was founded in 1891, and its activities began the following year.

  12. Using both cases and controls for testing hardy-weinberg proportions in a genetic association study.

    Science.gov (United States)

    Wang, Jian; Shete, Sanjay

    2010-01-01

    Assessment of the Hardy-Weinberg proportion (HWP) in controls has been widely used as a quality control measure in case-control association studies. However, when the disease being studied is common, controls might not represent the general population, which could result in inaccurate HWP test results. Such results could lead investigators to discard important single-nucleotide polymorphisms (SNPs) that could potentially be causal. In this paper, we showed the inappropriateness of the HWP test in controls and proposed a mixture HWP (mHWP) exact test using a mixture sample that mimics the general population. The mHWP exact test estimates HWP in a mixture sample that is a combination of both cases and controls proportional to the prevalence of disease. We implemented a re-sampling procedure to construct mixture samples and then obtained the empirical p value of HWP in the general population. Simulation studies were performed to investigate the performance of the proposed mHWP exact test. The method was also applied to a genetic association study of obesity. The results showed that the mHWP exact test is more likely than either the traditional HWP method in controls or the likelihood-based approach to keep causal SNPs for further analysis when the disease is more common. The mHWP exact test using a mixture sample is a better HWP test for case-control genetic association studies than the traditional HWP in controls or the likelihood-based approach, and it will improve our ability to keep causal SNPs in the case-control genetic association studies. Copyright 2010 S. Karger AG, Basel.

  13. The Essentiality of Reporting Hardy-Weinberg Equilibrium Calculations in Population-Based Genetic Association Studies.

    Science.gov (United States)

    Namipashaki, Atefeh; Razaghi-Moghadam, Zahra; Ansari-Pour, Naser

    2015-01-01

    Population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health. An essential quality control step in such studies is to undertake Hardy-Weinberg equilibrium (HWE) calculations. Deviations from HWE in the control group may reflect important problems including selection bias, population stratification and genotyping errors. If HWE is violated, the inferences of these studies may thus be biased. We therefore aimed to examine the extent to which HWE calculations are reported in genetic association studies published in Cell Journal(Yakhteh)(Cell J). Using keywords pertaining to genetic association studies, eleven relevant articles were identified of which ten provided full genotypic data. The genotype distribution of 16 single nucleotide polymorphisms (SNPs) was re-analyzed for HWE by using three different methods where appropriate. HWE was not reported in 60% of all articles investigated. Among those reporting, only one article provided calculations correctly and in detail. Therefore, 90% of articles analyzed failed to provide sufficient HWE data. Interestingly, three articles had significant HWE deviation in their control groups of which one highly deviated from HWE expectations (P= 9.8×10(-12)). We thus show that HWE calculations are under-reported in genetic association studies published in this journal. Furthermore, the conclusions of the three studies showing significant HWE in their control groups should be treated cautiously as they may be potentially misleading. We therefore recommend that reporting of detailed HWE calculations should become mandatory for such studies in the future.

  14. Testing Hardy-Weinberg proportions in a frequency-matched case-control genetic association study.

    Science.gov (United States)

    Wang, Jian; Shete, Sanjay

    2011-01-01

    In case-control genetic association studies, cases are subjects with the disease and controls are subjects without the disease. At the time of case-control data collection, information about secondary phenotypes is also collected. In addition to studies of primary diseases, there has been some interest in studying genetic variants associated with secondary phenotypes. In genetic association studies, the deviation from Hardy-Weinberg proportion (HWP) of each genetic marker is assessed as an initial quality check to identify questionable genotypes. Generally, HWP tests are performed based on the controls for the primary disease or secondary phenotype. However, when the disease or phenotype of interest is common, the controls do not represent the general population. Therefore, using only controls for testing HWP can result in a highly inflated type I error rate for the disease- and/or phenotype-associated variants. Recently, two approaches, the likelihood ratio test (LRT) approach and the mixture HWP (mHWP) exact test were proposed for testing HWP in samples from case-control studies. Here, we show that these two approaches result in inflated type I error rates and could lead to the removal from further analysis of potential causal genetic variants associated with the primary disease and/or secondary phenotype when the study of primary disease is frequency-matched on the secondary phenotype. Therefore, we proposed alternative approaches, which extend the LRT and mHWP approaches, for assessing HWP that account for frequency matching. The goal was to maintain more (possible causative) single-nucleotide polymorphisms in the sample for further analysis. Our simulation results showed that both extended approaches could control type I error probabilities. We also applied the proposed approaches to test HWP for SNPs from a genome-wide association study of lung cancer that was frequency-matched on smoking status and found that the proposed approaches can keep more genetic

  15. Powerful haplotype-based Hardy-Weinberg equilibrium tests for tightly linked loci.

    Science.gov (United States)

    Mao, Wei-Gao; He, Hai-Qiang; Xu, Yan; Chen, Ping-Yan; Zhou, Ji-Yuan

    2013-01-01

    Recently, there have been many case-control studies proposed to test for association between haplotypes and disease, which require the Hardy-Weinberg equilibrium (HWE) assumption of haplotype frequencies. As such, haplotype inference of unphased genotypes and development of haplotype-based HWE tests are crucial prior to fine mapping. The goodness-of-fit test is a frequently-used method to test for HWE for multiple tightly-linked loci. However, its degrees of freedom dramatically increase with the increase of the number of loci, which may lack the test power. Therefore, in this paper, to improve the test power for haplotype-based HWE, we first write out two likelihood functions of the observed data based on the Niu's model (NM) and inbreeding model (IM), respectively, which can cause the departure from HWE. Then, we use two expectation-maximization algorithms and one expectation-conditional-maximization algorithm to estimate the model parameters under the HWE, IM and NM models, respectively. Finally, we propose the likelihood ratio tests LRT[Formula: see text] and LRT[Formula: see text] for haplotype-based HWE under the NM and IM models, respectively. We simulate the HWE, Niu's, inbreeding and population stratification models to assess the validity and compare the performance of these two LRT tests. The simulation results show that both of the tests control the type I error rates well in testing for haplotype-based HWE. If the NM model is true, then LRT[Formula: see text] is more powerful. While, if the true model is the IM model, then LRT[Formula: see text] has better performance in power. Under the population stratification model, LRT[Formula: see text] is still more powerful. To this end, LRT[Formula: see text] is generally recommended. Application of the proposed methods to a rheumatoid arthritis data set further illustrates their utility for real data analysis.

  16. Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis.

    Science.gov (United States)

    Ziegler, Andreas; Van Steen, Kristel; Wellek, Stefan

    2011-07-01

    Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control studies. They criticized a meta-analytic study for the deviation from HWE in the case group of one study. The aim of this article is twofold. First, we derive recommendations on how to test for deviations from HWE in different study designs. Second, we develop a meta-analytic framework for assessing compatibility with HWE or measuring deviation from HWE. The authors sketch the possible reasons behind deviation from HWE and provide guidelines for proper investigation of HWE deviations in different study designs. The authors argue that the standard HWE χ² lack of fit test is logically flawed and provide a logically unflawed approach for measuring deviation from HWE using confidence intervals. The proposed method is applicable to meta-analyses of both case-control or cohort association studies. The proposed approach is illustrated using the meta-analysis criticized by Yu et al. Heterogeneity between studies can be assessed. The critique of Yu et al. to the article of Frank et al. (Breast Cancer Res Treat 111:139-144, 2008) can be refuted. Even more, validity of HWE can be proven for the pooled control sample. The authors advocate the use of a confidence interval-based approach to assess HWE. The latter should only be investigated in control populations. In multicenter studies or meta-analysis, deviation from HWE should be analyzed using a meta-analytic approach.

  17. In memory of Professor Paolo Talamucci

    Directory of Open Access Journals (Sweden)

    Cantiani M

    2010-05-01

    Full Text Available Paolo Talamucci, Full Professor of Range Management at the Università degli Studi in Florence from 1975 to 2001, passed away on 27th November 2009, after a brief and unrelenting illness. Professor Talamucci spent many long years in the field of research, in both Mediterranean and Alpine regions. His research, profoundly rooted in the territory he was studying, holistic in its approach and rigorously scientific, was characterized by a strong interdisciplinary element, seeking always to take into account the totality of the components of the ecosystem. Professor Talamucci was one of the first scholars of the pastoral system to highlight the problems related to the abandonment of traditional animal husbandry in mountainous zones and to look for ways to counteract the undesirable transformation of the landscape and the consequent loss of biodiversity. His curriculum and his numerous scientific publications bear testimony not only to the prestigious research institutes, world-wide, with which he was associated, but also to the important international dimension of his research.

  18. APOSENTADORIA: como professores vivenciam este momento?

    Directory of Open Access Journals (Sweden)

    Cristiane Nervis Conrado Machado

    2017-05-01

    Full Text Available O presente artigo buscou compreender as implicações que a aposentadoria causa na vida de professores, levando em conta o significado que a aposentadoria representa à estes, considerando os pontos de maior mudança após a aposentadoria, bem como os aspectos positivos e negativos causados pela aposentadoria na percepção dos sujeitos da pesquisa. Para tanto, foi realizada uma pesquisa qualitativa caracterizada como exploratória e descritiva com professores aposentados por mais de dois anos, com idade entre 58 e 66 anos, através de entrevistas individuais, com roteiros semiestruturados. A análise dos dados foi por meio da análise de conteúdo de Bardin (2011. Entre os principais resultados, destaca-se o significado de “liberdade” que a aposentadoria representa, a rotina como maior mudança e flexibilidade de horários dentre os pontos positivos e a falta dos alunos como aspecto negativo, contudo, pode-se perceber que a aposentadoria possibilitou e contribuiu para que os professores pudessem desfrutar de momentos de lazer, dedicando cuidado à família e realizando seus anseios e vontades.

  19. Riesgos competitivos de muerte y equilibrio de Hardy-Weinberg en estudios de casos y controles sobre asociación entre genes y enfermedades Competing risks of death and Hardy-Weinberg equilibrium in case-control studies of gene-disease association

    Directory of Open Access Journals (Sweden)

    Javier Llorca

    2005-08-01

    Full Text Available Objetivo: Estudiar el impacto de los riesgos competitivos sobre el equilibrio de Hardy-Weinberg y sus consecuencias en los estudios de casos y controles sobre la relación gen-enfermedades de comienzo tardío. Métodos: A partir de una población que, respecto de un determinado gen, se encuentre en equilibrio de Hardy-Weinberg al nacer, se deduce la composición genética cuando el gen está asociado con una enfermedad letal de aparición precoz, y sus consecuencias sobre una enfermedad de comienzo tardío. Cuando se realiza un estudio de casos y controles con muestreo por densidad se obtiene una estimación no sesgada de la odds ratio, a pesar de que los controles no estén en equilibrio de Hardy-Weinberg. Resultados: Se presenta un ejemplo en el que el gen mutante se asocia con una mayor mortalidad precoz al romper el equilibrio de Hardy-Weinberg y da lugar a que en un estudio realizado en edades más avanzadas los controles se encuentren en desequilibrio, con una odds ratio de 1,61. Conclusión: Aunque las principales causas de desequilibrio de Hardy-Weinberg en los controles son un sesgo de selección o un error de genotipificación, un riesgo competitivo de muerte asociado con el gen mutante puede ocasionar que la muestra de controles esté en desequilibrio de Hardy-Weinberg.Objective: To study the impact of competing risks on Hardy-Weinberg equilibrium and their consequences in case-control studies of gene-late onset disease association. Methods: Based on a population born in Hardy-Weinberg equilibrium for a particular gene, the genetic composition when the gene is associated with a lethal early-onset disease and its consequences on a late-onset disease can be deduced. Odds ratios estimates are unbiased in case-control studies when controls are sampled by density, even if the controls are in Hardy-Weinberg disequilibrium. Results: An example in which a mutant gene is associated with early mortality is presented, producing a departure from

  20. Visit of Professor Shigehiko Hasumi. President of Tokyo University, Japan, Professor Kazuo Okamoto, Head of Graduate School of Mathematical Sciences, Professor Toshiteru Matsuura, Head of Graduate School of Arts and Sciences

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    Visit of Professor Shigehiko Hasumi. President of Tokyo University, Japan, Professor Kazuo Okamoto, Head of Graduate School of Mathematical Sciences, Professor Toshiteru Matsuura, Head of Graduate School of Arts and Sciences

  1. A Beacon of Light: Tougaloo during the Presidency of Dr. Adam Daniel Beittel (1960-1964)

    Science.gov (United States)

    Speed, John Gregory

    2014-01-01

    This study examines leadership efforts that supported the civil rights movements that came from administrators and professors, students and staff at Tougaloo College between 1960 and 1964. A review of literature reveals that little has been written about the college's role in the Civil Rights Movement during this time. Thus, one goal of this study…

  2. Inferencia estadística para el equilibrio de Hardy-Weinberg en estudios de genotipado con datos faltantes

    OpenAIRE

    Sánchez Mayor, Milagros

    2012-01-01

    Los marcadores genéticos, los SNPs entre ellos, cumplen en general una ley básica, la ley de Hardy-Weinberg (HWE) y existen varios procedimientos estadísticos para comprobar si marcadores genéticos concuerdan con esta ley o no. En las pruebas estadísticas para HWE siempre se descartan los genotipos faltantes. El objetivo de este trabajo consiste en llevar a cabo inferencia para HWE teniendo en cuenta los datos faltantes. Modern genotyping technology generates large databases of markers (SN...

  3. Deviations from Hardy-Weinberg frequencies caused by assortative mating in hybrid populations.

    Science.gov (United States)

    Shockley, W

    1973-03-01

    The conventional formulas for genotype frequencies in a hybrid population H produced by interbreeding from ancestral populations P(1) and P(2) involve only one hybrid parameter M, equal to the fraction of alleles derived from P(2). For the one-parameter model to be accurate, all individuals of H must have probabilities for alleles determined by one and the same M. When H contains subpopulations that have different values of M, the correct genotype frequencies can be predicted by use of two parameters: (i) M(H), the average of M for all individuals of H and (ii) eta(H), defined like the eta devised by C. A. B. Smith for testing the Hardy-Weinberg Law and computed with a formula like G. R. Price's eta, which involves assortative mating covariance-in this case for the M values of the parents of H. If parents of H have equal average M values for males and females, and mate at random, eta(H) vanishes. For perfect assortative mating, eta(H) is the variance of M for H. As for Smith's eta, eta(H) provides a test of fit of prediction to observed that is sensitive to signs of deviations. Using eta(H) with T. E. Reed's data for Gm in Oakland, California Negroes, his one-parameter fit ("good" by his chi-square test) is significantly rejected (P = 0.04). A simultaneous good fit of Reed's Gm data and his Duffy data results (chi-square, 1 df = 0.88, P > 0.30) from the use of previously published values of 0.23 and 0.047 for M(H) and eta(H). It is concluded that Reed's conclusion that these values were in error is itself in error, as is also his view that differences between M values from different genes and deviations from frequencies expected within genes are not likely to give significant information about variance of M.

  4. Religiosidade em alunos e professores portugueses

    OpenAIRE

    Ferreira, Ana Maria Mendes dos Santos Veríssimo

    2005-01-01

    Tese de Doutoramento em Ciências da Educação na especialidade de Educação Intercultural apresentada à Universidade Aberta Esta tese pretende analisar a religiosidade em alunos e professores, sendo a religiosidade entendida como o grau de ligação ou aceitação que cada indivíduo tem face à instituição religiosa (Alston, 1875) e à forma como põe em prática as crenças e os rituais (Shafranske e Malony, 1990). Para medir a religiosidade foram utilizados diversos instrumentos – a escala de Atitu...

  5. Professor Stewart's hoard of mathematical treasures

    CERN Document Server

    Stewart, Ian

    2010-01-01

    Ian Stewart, author of the bestselling Professor Stewart's Cabinet of Mathematical Curiosities, presents a new and magical mix of games, puzzles, paradoxes, brainteasers, and riddles. He mingles these with forays into ancient and modern mathematical thought, appallingly hilarious mathematical jokes, and enquiries into the great mathematical challenges of the present and past. Amongst a host of arcane and astonishing facts about every kind of number from irrational or imaginary to complex or cuneiform, we find out: how to organise chaos; how matter balances anti-matter; how to turn a sphere i

  6. Boodskap van Professor Dr. J. Waterink

    Directory of Open Access Journals (Sweden)

    J. Waterink

    1955-03-01

    Full Text Available Boodskap van Professor Dr. J. Waterinkter gelegendheid van die verlening aan hem van de graad Doctor Educationis, honoris causa, door de Universiteit voor Christelijk Hoger Onderwijs te Potchefstroom op Zaterdag, 26 Maart 1955, en op die dag voorgelezen door de heer Jan van den Berg, Buitengewoon en Gevolmachtigd Ambassadeur van Hare Mi iesteit de Koningin der Nederlanden. Mijnheer, de Kanselier, Mijnheer de Voorzitter van de Raad, Mijnheer deVice-Kanselier en Rector, overige Heren ambtsdragers, en gij alien,die herwaarts kwaanit ter gelegenheid van deze Gradendag,zeer geachte en zeer gewenste toehoorders.

  7. Daniel Dragonslayer – Bel and the dragon, Verses 23−27 (OG/Th

    Directory of Open Access Journals (Sweden)

    Joseph J. de Bruyn

    2015-03-01

    Full Text Available In this article, aspects of narrative critique, genre, editorial critique, the body and space are uniquely combined into a body-space framework. This spatial framework is used to examine the second episode of ‘Bel and the Dragon’, called ‘Daniel Dragonslayer’. It is postulated that the second episode of ‘Bel and the Dragon’ should be read in a reciprocal relationship with not only ‘Bel and the Dragon’, but also the larger Book of Daniel. Firstly, such an analysis indicates that the smaller episode is part of a larger clash of deities. Secondly, it shows that the editor /author utilises the episode to create a new cosmology. In this new cosmology, the Jewish deity is an almighty one, whilst other deities are seen as false and not real living gods. In his own way, the editor or author contributes to the way in which Jews regarded their God within the reality of the diaspora.Daniel Dragonslayer − Bel en die draak, Verse 23−27 (VAN/Die. In hierdie artikel word aspekte van narratiewe-kritiek, genre, redaksie-kritiek, die liggaam en ruimte op ’n unieke wyse gekombineer om ’n beliggaamde ruimteraamwerk te vorm. Hierdie beliggaamde ruimteraamwerk word gebruik om die tweede episode van ‘Bel en die Draak’, naamlik ‘Daniël, die Draakjagter’, te analiseer. Die artikel stel voor dat hierdie tweede episode van ‘Bel en die Draak’ in ’n resiproke verhouding met ‘Bel en die Draak’, sowel as met die boek Daniël gelees moet word. Indien die teks op hierdie voorgestelde wyse ontleed word, kom verskeie punte na vore. Eerstens word aangedui dat die kleiner episode deel van ’n groter gode-oorlog vorm. Tweedens, die skrywer/redakteur gebruik die kleiner episode as deel van ’n proses om ’n nuwe kosmologie te skep. Volgens hierdie nuwe kosmologie is die Joodse God ’n almagtige God, terwyl ander gode vals en nie ware lewende gode is nie. Op sy eie manier lewer die skrywer/redakteur ’n bydrae tot die

  8. Habitus professoral na sala de aula virtual

    Directory of Open Access Journals (Sweden)

    Alexandre Marinho Pimenta

    2014-09-01

    Full Text Available Entendendo que a indiferença na ação pedagógica contribui para a reprodução das desigualdades no sistema de ensino, o presente artigo busca captar, a partir de entrevistas semiestruturadas, traços do habitus de professores supervisores de disciplinas do curso de Licenciatura em Pedagogia na modalidade a distância na Universidade de Brasília - UnB no âmbito do Sistema Universidade Aberta do Brasil - UAB. As orientações metodológicas de Bourdieu (2007 foram um dos elementos orientadores na análise das entrevistas, considerando ainda o uso heurístico do conceito de habitus. Conclui-se que o habitus professoral envolve esforços voluntários em busca de uma ação pedagógica diferenciada. No entanto, ele é ambíguo e condescendente frente aos limites do modelo de EaD no âmbito da UAB. Ao fim, os dados analisados permitem fornecer elementos para reorientação político-pedagógica que vise a um novo modelo de EaD nacional.

  9. Entrevista com o professor Salomon Turnowski

    Directory of Open Access Journals (Sweden)

    Carolina Lima Vilela

    2014-01-01

    Full Text Available Com aproximadamente 50 anos de experiências profissionais variadas em Geografia, o Professor Salomon Turnowski se revela, até hoje, um apaixonado por nosso campo de conhecimento. Em entrevista realizada pela equipe da Revista Giramundo, em junho de 2009, na Unidade Escolar Humaitá II, a disposição de contar sua trajetória parece movida pelos comentários a respeito de nossa ciência, de suas transformações e de sua paixão pelos livros. Atuante no Colégio Pedro II, onde lecionou entre 1984 e 2009, no IBGE e na antiga FIDERJ (Fundação Instituto de Desenvolvimento do Estado do Rio de Janeiro, entre outros, seu depoimento se revela, portanto, uma oportunidade para conhecer um pouco mais sobre sujeitos e instituições voltados à construção da Geografia no Brasil e no Rio de Janeiro, assim como sobre os contrastes entre as vivências de geógrafos e de professor. Fica aqui o registro acerca da experiência valiosa e diversificada desse profissional, assim como uma singela homenagem.

  10. Entrevista com o professor Rafael Straforini

    Directory of Open Access Journals (Sweden)

    Demian Garcia Castro

    2015-07-01

    Full Text Available Com vivência profissional na Educação Básica e na Superior, além de experiência de pesquisa em diferentes instituições universitárias nos estados de São Paulo e do Rio de Janeiro, o professor Rafael Straforini pode ser considerado uma das novas vozes importantes na área do Ensino de Geografia. Assim como na edição anterior, uma vez mais utilizamo-nos de plataforma digital e, na conexão direta Rio-Campinas, tivemos a oportunidade de abordar questões como a Geografia na Educação Infantil e nas séries iniciais do Ensino Fundamental, o currículo e a formação de professores, além de aproveitar um pouco para conversar sobre Geografia Histórica e a Revista Brasileira de Educação em Geografia. Agradecemos a Straforini pela oportunidade e deixamos o leitor com o resultado desse encontro virtual.

  11. When Professors Don't Return Essays.

    Science.gov (United States)

    Feldman, William; Dhaliwal, Gurpreet

    2015-01-01

    Students devote hundreds of hours to writing notes during medical school clerkships but receive very limited feedback on that work. Medical student notes are like college essays-both are persuasive compositions. But attending physicians rarely scrutinize student notes like college professors analyze essays. This is a missed opportunity to teach clinical reasoning. A survey at our institution showed that only 16% of students received written feedback and 31% received oral feedback on their notes from more than 3 attending physicians during the first 8 months of 3rd-year clerkships. Many studies have reported a paucity of feedback across multiple domains and a sense among students that clinical reasoning is not being adequately taught during clerkships. Meanwhile, college professors teach written composition and reasoning through interactive methods that help students to develop structured, well-reasoned arguments. A recent study showed that 85% of Oxford undergraduates favored these demanding and time-intensive tutorials. Attending physicians who adopt a tutorial-based approach toward their students' notes would have a forum to teach clinical reasoning and emphasize the importance of written composition in medical practice.

  12. FORMANDO PROFESSORES: UMA HEURÍSTICA REFLEXIVA

    Directory of Open Access Journals (Sweden)

    Tania Gastão Saliés

    2011-03-01

    Full Text Available O presente estudo reflete criticamente sobre a formação do professor de LE à luz da condição pós-método, com o intuito de contribuir para a ação de programas de formação.  Dentre outras questões, ilumina a importância de o professor em formação construir percepção sobre o contexto e de si próprio como agente da própria formação.  Para tal, primeiro trata de aspectos filosóficos presentes no contra-discurso da condição pós-método, em seguida destaca a conscientização sobre o papel do contexto no ensino-aprendizagem de línguas e finalmente  apresenta uma heurística reflexiva com potencial de guiar as ações dos cursos de formação.    

  13. The “Journal d’un corps” by Daniel Pennac

    Directory of Open Access Journals (Sweden)

    Elena Cappellini

    2014-03-01

    Full Text Available The influence that ancient and modern devices of representation of the body have on the work of some contemporary authors is central to the book Corpi in frammenti. Anatomia, radiologia, fotografia e forma breve del narrare (Le Lettere, Firenze 2013. It is proposed here the final part of the volume, which summarizes many of the issues investigated, by analyzing the recent novel Journal d’un corps by Daniel Pennac. This detailed narration of the physical changes occurred over the course of a lifetime reveals the unreachable distance between the subject and the specular, photographic, medical images of the subject’s own body, as well as the therapeutic role of journal writing, an act that is capable of healing this rift.

  14. Daniel Prieto Castillo y la utopía pedagógica

    Directory of Open Access Journals (Sweden)

    Kintto Lucas

    2015-01-01

    Full Text Available En la entrevista realizada a Daniel Prieto Castillo, éste afirma que entre lo que produce la cultura, las prácticas, los saberes y quienes están en situación de aprender siempre hay mediaciones sociales. Al opinar sobre la educación alternativa dice que hay una explosión de lo alternativo porque hay una explosión de la sociedad civil en todos, los campos. Discrepa de los programas infantiles como el dirigido por XUXA por su terrible violencia referida a la saturación de sonido de la animadora no hay silencio, pausa o respiro solo gritos, es de un manipuleo insoportable.

  15. The Fluor Daniel ECONAMINE FG process: past experience and present day focus

    Energy Technology Data Exchange (ETDEWEB)

    Sander, M.T.; Mariz, C.L. (Fluor Daniel Inc., Irvine, CA (USA))

    1992-01-01

    The Fluor Daniel ECONAMINE FG CO{sub 2} recovery process has many unique advantages and is used in commercial installations worldwide. Since its introduction by Dow Chemical in the early-1980s, this process has been used in the food and chemical process industries as well as in Enhanced Oil Recovery (EOR) applications. The process uses an amine solution to remove CO{sub 2} economically from low-pressure, oxygen-containing streams such as flue gas. The use of a proprietary additive in the amine solution enables operation at high solution strength and acid gas loading while utilizing conventional materials of construction. This proven process has still further relevance in meeting the challenges of today's processing needs, as it can offer a technically feasible means of reducing atmospheric CO{sub 2} emissions. 6 refs., 7 figs., 3 tabs.

  16. Fluor Daniel Hanford Inc. integrated safety management system phase 1 verification final report

    Energy Technology Data Exchange (ETDEWEB)

    PARSONS, J.E.

    1999-10-28

    The purpose of this review is to verify the adequacy of documentation as submitted to the Approval Authority by Fluor Daniel Hanford, Inc. (FDH). This review is not only a review of the Integrated Safety Management System (ISMS) System Description documentation, but is also a review of the procedures, policies, and manuals of practice used to implement safety management in an environment of organizational restructuring. The FDH ISMS should support the Hanford Strategic Plan (DOE-RL 1996) to safely clean up and manage the site's legacy waste; deploy science and technology while incorporating the ISMS theme to ''Do work safely''; and protect human health and the environment.

  17. Poema en prosa y mundos especulativos: en torno a Les Chasseurs du temps de Daniel Walther

    Directory of Open Access Journals (Sweden)

    Mariano Martín Rodríguez

    2016-04-01

    Full Text Available The prose poem has traditionally been considered above all a lyrical genre. Never-theless, there are short fictions showing the main features of the prose poem, such as brevity, intensity, autonomy, importance of connotation, visionary character and, above all, the dominance of description. The fic-tional prose poem gives shape to an imagi-nary world which is poetically described, rather than narrated. The fictional character of this kind of prose poem is especially clear when what is described is a future reality, as it is the case in Stéphane Mallarmé’s «Le Phénomène futur» and in later series of prose poems which create prospective uni-verses. Among them, the series collected by Daniel Walther in 2010 under the title of Les Chasseurs du temps stands out for its mysterious force, its fictional coherence and the beauty of its images.

  18. Daniel Landis: Award for Distinguished Contributions to the International Advancement of Psychology.

    Science.gov (United States)

    2012-11-01

    Presents a short biography of one of the co-recipients of the American Psychological Association's Award for Distinguished Contributions to the International Advancement of Psychology. One of the 2012 winners is Daniel Landis for his unparalleled contribution to the field of intercultural research in a distinguished academic career spanning almost half a century. Landis has shaped the field of intercultural research through scholarship of the highest order, reflected in his publications on cross-cultural training and research, the measurement of equal opportunity climate, individual-differences research and methodology, evaluation of social programs, development of theory in social psychology, and cross-cultural aspects of human sexuality. He is the founding editor-in-chief of the International Journal of Intercultural Relations and has edited three editions of the Handbook of Intercultural Training (1983, 1996, 2004). Landis' Award citation and a selected bibliography are also presented. PsycINFO Database Record (c) 2012 APA, all rights reserved.

  19. On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers.

    Science.gov (United States)

    Graffelman, Jan; Weir, Bruce S

    2018-02-01

    Standard statistical tests for equality of allele frequencies in males and females and tests for Hardy-Weinberg equilibrium are tightly linked by their assumptions. Tests for equality of allele frequencies assume Hardy-Weinberg equilibrium, whereas the usual chi-square or exact test for Hardy-Weinberg equilibrium assume equality of allele frequencies in the sexes. In this paper, we propose ways to break this interdependence in assumptions of the two tests by proposing an omnibus exact test that can test both hypotheses jointly, as well as a likelihood ratio approach that permits these phenomena to be tested both jointly and separately. The tests are illustrated with data from the 1000 Genomes project. © 2017 The Authors Genetic Epidemiology Published by Wiley Periodicals, Inc.

  20. Hardy-Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism.

    Science.gov (United States)

    Yonan, Amanda L; Palmer, Abraham A; Gilliam, Thomas Conrad

    2006-02-01

    We analyzed the putative functional promoter polymorphism of the serotonin transporter (5-HTTLPR) in two large autism spectrum disorder samples and a control sample. A Hardy-Weinberg disequilibrium was detected for 5-HTTLPR in the unaffected founders of both autism spectrum disorder samples and control samples. When we lowered the total magnesium concentration in the polymerase chain reaction below levels reported in previously published studies, we observed a shift in relative allele frequencies and restoration of the Hardy-Weinberg equilibrium. Our data suggest that higher magnesium concentrations caused allele-dependent, non-random genotyping errors. Genotyping data obtained from the 2 mM magnesium protocol increased the significance of linkage and gave suggestive (P=0.06) association with autism spectrum disorder, whereas the corrected genotypes of 5-HTTLPR provide no linkage information beyond the results we have previously published and no evidence of association with autism spectrum disorder. We present details regarding appropriate polymerase chain reaction conditions for the accurate genotyping of this polymorphism.

  1. Bond-girl Eva Green: "Daniel ei ole sugugi halb" / Eva Green ; ref. Viktoria Ladõnskaja

    Index Scriptorium Estoniae

    Green, Eva

    2006-01-01

    Ajakirjanikud vaatasid Londonis uut Bondi-filmi "007 : Casino Royale" ja kohtusid pressikonverentsil peaosatäitjatega. Prantsusmaal elav rootsi-alžeeria päritolu näitlejanna Eva Green räägib oma rollist ja koostööst Bondi-kehastaja Daniel Craigiga

  2. Characterization and differentiation of Italian Parma, San Daniele and Toscano dry-cured hams: a multi-disciplinary approach.

    Science.gov (United States)

    Laureati, Monica; Buratti, Susanna; Giovanelli, Gabriella; Corazzin, Mirco; Lo Fiego, Domenico P; Pagliarini, Ella

    2014-01-01

    This study aimed at characterizing the sensory quality of Italian PDO dry-cured Parma, San Daniele and Toscano hams, applying a multi-disciplinary approach. Ham sensory profile as well as physico-chemical, aromatic, morphological and textural characteristics was investigated. There was a great difference between Toscano ham and Parma and San Daniele hams, which were more similar even though differentiated. Toscano ham showed higher scores for pork-meat odor, saltiness, dryness, fibrousness and hardness; accordingly, this ham was described by a high NaCl content and by high values of instrumental hardness, cohesiveness, gumminess and chewiness. Parma ham was characterized by a cured flavor, whereas San Daniele ham showed a wider fatty area and higher pH values. Parma and San Daniele hams were also described by higher values of sweetness, RGB color values and water activity. Sensory characteristics evaluated by trained assessors were correlated to instrumental measures, indicating that instrumental devices can be effectively applied for dry-cured ham characterization. © 2013.

  3. What Costs Do Reveal and Moving beyond the Cost Debate: Reply to Einstein and McDaniel (2010)

    Science.gov (United States)

    Smith, Rebekah E.

    2010-01-01

    Einstein et al. (2005) predicted no cost to an ongoing task when a prospective memory task met certain criteria. Smith, Hunt, McVay, and McConnell (2007) used prospective memory tasks that met these criteria and found a cost to the ongoing task, contrary to Einstein et al.'s prediction. Einstein and McDaniel (2010) correctly noted that there are…

  4. Research on Youth in an Age of Complexity: The Rockefeller Youth Task Force and Daniel Yankelovich, 1965-1975

    Science.gov (United States)

    Richardson, Theresa M.

    2008-01-01

    The period between 1965 and 1975 encompasses important events associated with the peak of the youth movement in the 1960s and its demise in the 1970s. The period was an "age of complexity" according to Daniel Yankelovich, a social scientist hired by John D. Rockefeller 3rd's Youth Task Force to study the wave of protests that Rockefeller felt…

  5. Is Julian Assange an International Version of Daniel Ellsberg and WikiLeaks the Modern Equivalent of the Pentagon Papers?

    Science.gov (United States)

    Freivogel, William H.

    2011-01-01

    History has placed the stamp of approval on the publication of the Pentagon Papers, the top-secret history of the Vietnam War. If WikiLeaks editor-in-chief Julian Assange is another Daniel Ellsberg, then it is possible the website's disclosures will be viewed over time as similarly in the public interest. A classroom discussion on the release of…

  6. Professor Gender, Age, and “Hotness” in Influencing College Students’ Generation and Interpretation of Professor Ratings

    Directory of Open Access Journals (Sweden)

    Sara L. Sohr-Preston

    2016-09-01

    Full Text Available Undergraduate psychology students rated expectations of a bogus professor (randomly designated a man or woman and hot versus not hot based on an online rating and sample comments as found on RateMyProfessors.com (RMP. Five professor qualities were derived using principal components analysis (PCA: dedication, attractiveness, enhancement, fairness, and clarity. Participants rated current psychology professors on the same qualities. Current professors were divided based on gender (man or woman, age (under 35 or 35 and older, and attractiveness (at or below the median or above the median. Using multivariate analysis of covariance (MANCOVA, students expected hot professors to be more attractive but lower in clarity. They rated current professors as lowest in clarity when a man and 35 or older. Current professors were rated significantly lower in dedication, enhancement, fairness, and clarity when rated at or below the median on attractiveness. Results, with previous research, suggest numerous factors, largely out of professors’ control, influencing how students interpret and create professor ratings. Caution is therefore warranted in using online ratings to select courses or make hiring and promotion decisions.

  7. Professor Gender, Age, and “Hotness” in Influencing College Students’ Generation and Interpretation of Professor Ratings

    Directory of Open Access Journals (Sweden)

    Sara L. Sohr-Preston

    2016-09-01

    Full Text Available Undergraduate psychology students rated expectations of a bogus professor (randomly designated a man or woman and hot versus not hot based on an online rating and sample comments as found on RateMyProfessors.com (RMP. Five professor qualities were derived using principal components analysis (PCA: dedication, attractiveness, enhancement, fairness, and clarity. Participants rated current psychology professors on the same qualities. Current professors were divided based on gender (man or woman, age (under 35 or 35 and older, and attractiveness (at or below the median or above the median. Using multivariate analysis of covariance (MANCOVA, students expected hot professors to be more attractive but lower in clarity. They rated current professors as lowest in clarity when a man and 35 or older. Current professors were rated significantly lower in dedication, enhancement, fairness, and clarity when rated at or below the median on attractiveness. Results, with previous research, suggest numerous factors, largely out of professors’ control, influencing how students interpret and create professor ratings. Caution is therefore warranted in using online ratings to select courses or make hiring and promotion decisions. 

  8. Institutional Support for the Virtual Professor

    Directory of Open Access Journals (Sweden)

    Tom JONES

    2004-01-01

    Full Text Available Academics who hold positions at single-mode, distance education institutions are presently being hampered by an adherence to a long-standing set of protocols (specific office location, face-to-face meetings that were put in place when the conventional post-secondary was the norm. With the advent of a powerful merging of personal computers and the internet, a shift from those protocols to one of support for the virtual professor is in the offing, to the benefit of both the professoriate and the student. A key factor in this shift is the degree and quality of institutional support that will allow these changes to take place. This paper focuses on a number of the key factors that will have to be addressed if this new type of distance education academic is to function effectively.

  9. Students' Needs Analysis in an EFL Program for University Professors

    Science.gov (United States)

    Bedoya, Paula Andrea; Valencia, Luz María; Montoya, Juan Carlos

    2016-01-01

    This study sets out to investigate professors' needs from an English as a foreign language program in a public university regarding demands, interests, and lacks based on the methodology of needs analysis. Data collected through a survey, focus groups, and individual interviews showed that professors need to meet the institutional language policy…

  10. Rate My Professor: Online Evaluations of Psychology Instructors

    Science.gov (United States)

    Silva, Kathleen M.; Silva, Francisco J.; Quinn, Megan A.; Draper, Jill N.; Cover, Kimberly R.; Munoff, Alison A.

    2008-01-01

    We analyzed students' ratings and comments of their psychology instructors that were posted on RateMyProfessors.com and RateMyProfessors.ca to determine which features of a course and an instructor evoked the most positive and negative reactions. A content analysis of students' comments showed that instructors' characteristics(e.g., enthusiastic,…

  11. More Colleges Offer Part-Time Options for Professors

    Science.gov (United States)

    Wilson, Robin

    2008-01-01

    The University of California campuses are among a small but growing number of research universities adopting new policies--or reinvigorating old ones--that allow tenure-track and tenured professors to work part time. Typically, professors interested in scaling back their work want more time to care for young children, a sick relative, or an aging…

  12. Child Rearing as a Career Impediment to Women Assistant Professors.

    Science.gov (United States)

    Finkel, Susan Kolker; Olswang, Steven G.

    1996-01-01

    Over 40% of women assistant professors in a recent survey (n=124) identified publishing, teaching, committees, and "time required by children" as serious impediments to achieving tenure, many more than reported sexual harassment and sexism as serious obstacles. Policy changes that will accommodate women professors' time commitments to…

  13. Do Professors Have Customer-Based Brand Equity?

    Science.gov (United States)

    Jillapalli, Ravi K.; Jillapalli, Regina

    2014-01-01

    This research endeavors to understand whether certain professors have customer-based brand equity (CBBE) in the minds of students. Consequently, the purpose of this study is to conceptualize, develop, and empirically test a model of customer-based professor brand equity. Survey data gathered from 465 undergraduate business students were used to…

  14. Academic Labor Markets and Assistant Professors' Employment Outcomes

    Science.gov (United States)

    Hargens, Lowell L.

    2012-01-01

    Using data for 638 assistant professors who joined graduate sociology departments between 1975 and 1992, I examine the claim that when the labor market for new doctorates is weak, assistant professors experience less favorable employment outcomes than when that labor market is strong. Surprisingly, I find that those hired during the weak…

  15. Effects of Social Support on Professors' Work Stress

    Science.gov (United States)

    Moeller, Christin; Chung-Yan, Greg A.

    2013-01-01

    Purpose: The purpose of this paper is to examine how various types of workplace social support from different support sources interact with occupational stressors to predict the psychological well-being of university professors. Design/method/approach: A total of 99 full-time professors participated via an online or paper questionnaire. Findings:…

  16. Mentoring by the Community College Professor: One Role among Many

    Science.gov (United States)

    Galbraith, Michael; James, Waynne

    2004-01-01

    The process of mentorship in relationship to the community college professor and the potential to improve and enhance the teaching and learning process is explored in this article. This article suggests that not all community college professors are psychological or intellectually disposed to being or becoming a good mentor. It is put forth that…

  17. 26 CFR 521.114 - Visiting professors or teachers.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Visiting professors or teachers. 521.114... of Denmark and of Danish Corporations § 521.114 Visiting professors or teachers. Under Article XIV of... States for the purpose of teaching, lecturing, or instructing at any university, college, school, or...

  18. Mental Health Assessment in Professors' Training in Two Chilean Universities

    Science.gov (United States)

    Ossa, Carlos J.; Quintana, Ingrid M.; Rodriguez, Felipe F.

    2015-01-01

    This study analyzed the evaluation of professors of pedagogy and directors programs, about the importance of mental health in vocational training, and factors that might influence this valuation. The methodology includes participation of 17 academicians (professors and belonging to the managerial staff) of two universities in southern Chile. A…

  19. Differentiated Instruction: Are University Reading Professors Implementing It?

    Science.gov (United States)

    Williams-Black, Thea Hayes; Bailey, Jennifer P.; Lawson, Pamela D. Coleman

    2010-01-01

    This qualitative study surveyed university professors of literacy education to explore "how" and "if" they modeled differentiated instruction in their own college classrooms. A survey in questionnaire format on "how" and "if" University Reading Professors differentiate instruction was sent to a purposeful…

  20. University Pedagogy for Assistant Professors at Aalborg University (Part 2)

    DEFF Research Database (Denmark)

    Kolmos, Anette; Krogh, Lone

    2003-01-01

    In issue 1-2003, Anette Kolmos and Lone Krogh reported on the two-semester study course " University Pedagogy for Assistant Professors at Aalborg University (DK)". Now, in part 2, they are adressing guidelines for supervison and advising of assistant professors in the university teacher education...

  1. Student and Professor Gender Effects in Introductory Business Statistics

    Science.gov (United States)

    Haley, M. Ryan; Johnson, Marianne F.; Kuennen, Eric W.

    2007-01-01

    Studies have yielded highly mixed results as to differences in male and female student performance in statistics courses; the role that professors play in these differences is even less clear. In this paper, we consider the impact of professor and student gender on student performance in an introductory business statistics course taught by…

  2. In commemoration of professor V.P. Karpov

    Directory of Open Access Journals (Sweden)

    Semyonova L.S.

    2013-10-01

    Full Text Available This article is about professor Karpov V.P., a prominent scientist, first rector of Yekaterinoslav Medical Academy. Biography of a great investigator, his main achievements in the area of histology, biology, theory and history of medicine was studied. Professor Karpov V.P. always combined his great scientific, organizational and research work with social activity. Monographs of professor Karpov V.P. and conferences organized by him were of great importance in the solution of such new problems as theary of microscope and cell amitosis. Professor Karpov is a founder of a large school of histology. Thanks to his active participation and personal guidance, in 1917 department of histology was founded in Yekaterinoslav Medical Institute. The author of the article has analyzed Hippocrates` works translated into Russian by professor Karpov V.P. and pointed out their significance for modern medical science and practice.

  3. Professor I I Glass A Tribute and Memorial

    CERN Document Server

    Igra, Ozer

    2013-01-01

    The book provides personal memories along with description of scientific works written by ex-graduate students and research associates of the late Professor Glass. The described research work covers a wide range of shock wave phenomena, resulting from seeds planted by Professor Glass. Professor Glass was born in Poland in 1918. He immigrated together with his parents to Canada at the age of 12 and received all his professional education at the University of Toronto, Canada. He became a world recognized expert in shock wave phenomena, and during his 45 years of active research he supervised more than 125 master and doctoral students, post-doctoral fellows and visiting research associates. In this book seven of his past students/research-associates describe their personal memories of Professor Glass and present some of their investigations in shock wave phenomena which sprung from their past work with Professor Glass. Specifically, these investigations include underwater shock waves, shock/bubble interaction, m...

  4. Daniel Bell's theory of the coming of the post-industrial society

    Directory of Open Access Journals (Sweden)

    Stojić Gordana V.

    2016-01-01

    Full Text Available Twenty-five years after the publication of the famous Daniel Bell's book The Coming of Post-industrial Society, new edition of the book was published with a foreword written by the author named 'The Axial Age of Technology'. In the foreword Bell clarifies his theses and predictions in relation to the changes that have taken place in meantime in contemporary society, as well as regarding to the critics of his theory. The aim of the paper is to show how Bell explains social development in the second half of the twentieth century as well as the main characteristics of that society of 'transitory nature' in which we live. Bell's starting theoretical and methodological point of view are discussed as well as the explanation of transition from industrial to post-industrial society and the possibilities of development of the third world societies. The main characteristic of post-industrial society, according to Bell, is the codification of theoretical knowledge and the new relation between science and technology. Main post-industrial developments are: the rise of service sector, occupational changes, changes in professions and education, growing role of financial and human capital, new forms of infrastructure and knowledge theory of value. New form of society is emerging, with changes in stratification system, economy, organization and consumption. Bell doesn't plead for a holistic view of society. Instead, he considers society as comprising three realms that can change in different ways, so historical change is not unified. Major instrument of historical change is technology, it poses problems for culture and political system but it doesn't determine them. He rejects the accusations of technological determinism because technology often operates in context it doesn't make. Daniel Bell was one of the first authors who stated that modern society had been fundamentally changing. His aim was to make a conceptual framework for the comprehensive explanation

  5. Hardy-Weinberg disequilibrium of the IL-18 C-607A SNP suggesting selective advantage of heterozygotes.

    Science.gov (United States)

    Chen, Chuan Fei; Gan, Yik Yuen

    2012-02-01

    Interleukin-18 (IL-18) plays a key role in autoimmune, inflammatory, and infectious diseases. The IL-18 gene contains a C to A single nucleotide polymorphism (SNP) at position -607 (C-607A) within the promoter region, which was found to affect the promoter activity and subsequently the protein level of IL-18. We investigated this SNP in a group of healthy Singaporeans and found that CA was the most common genotype and the C allele was more prevalent than the A allele, which was not always the case in other ethnic groups. In addition, Singaporean Chinese were significantly different from Singaporean Indians in both allelic and genotypic distributions. Furthermore, significant deviations from Hardy-Weinberg equilibrium of this SNP were found in all three ethnic groups studied (Chinese, Indians, and Malays) and also in other published literature, suggesting that heterozygotes of this IL-18 C-607A SNP may have certain selective advantages.

  6. On S.N. Bernstein's derivation of Mendel's Law and 'rediscovery' of the Hardy-Weinberg distribution.

    Science.gov (United States)

    Stark, Alan; Seneta, Eugene

    2012-04-01

    Around 1923 the soon-to-be famous Soviet mathematician and probabilist Sergei N. Bernstein started to construct an axiomatic foundation of a theory of heredity. He began from the premise of stationarity (constancy of type proportions) from the first generation of offspring. This led him to derive the Mendelian coefficients of heredity. It appears that he had no direct influence on the subsequent development of population genetics. A basic assumption of Bernstein was that parents coupled randomly to produce offspring. This paper shows that a simple model of non-random mating, which nevertheless embodies a feature of the Hardy-Weinberg Law, can produce Mendelian coefficients of heredity while maintaining the population distribution. How W. Johannsen's monograph influenced Bernstein is discussed.

  7. On S.N. Bernstein's derivation of Mendel's Law and 'rediscovery' of the Hardy-Weinberg distribution

    Directory of Open Access Journals (Sweden)

    Alan Stark

    2012-01-01

    Full Text Available Around 1923 the soon-to-be famous Soviet mathematician and probabilist Sergei N. Bernstein started to construct an axiomatic foundation of a theory of heredity. He began from the premise of stationarity (constancy of type proportions from the first generation of offspring. This led him to derive the Mendelian coefficients of heredity. It appears that he had no direct influence on the subsequent development of population genetics. A basic assumption of Bernstein was that parents coupled randomly to produce offspring. This paper shows that a simple model of non-random mating, which nevertheless embodies a feature of the Hardy-Weinberg Law, can produce Mendelian coefficients of heredity while maintaining the population distribution. How W. Johannsen's monograph influenced Bernstein is discussed.

  8. OBITUARY: Professor Jan Evetts in memoriam

    Science.gov (United States)

    Dew-Hughes, David; Campbell, Archie; Glowacki, Bartek

    2005-11-01

    It is with great sadness that we report the death of Jan Evetts, who lost his second battle with cancer on 18 August 2005. In 1988 he was appointed Founding Editor of this journal where his leadership created the foundation upon which its success rests today. He made an outstanding series of contributions to the science of superconductivity and to the understanding of superconducting materials, and was an indefatigable champion of the development of applications of superconductivity. The loss to the scientific community is incalculable, as is attested by the many communications received from colleagues throughout the world. Professor Jan Edgar Evetts (1939-2005) Professor Jan Edgar Evetts (1939-2005) Jan was born on 31 March 1939, and attended the Dragon School in Oxford, and later Haileybury. He was awarded an exhibition to read Natural Sciences at Pembroke College, Cambridge in 1958 and took his BA degree in 1961. He then undertook a Certificate of Postgraduate Study in Physics under the supervision of Professor Neville Mott. He was the first student to undertake this newly-instituted course; the title of his thesis was `The Resistance of Transition Metals'. In 1962 he joined David Dew-Hughes' embryonic superconducting materials research group, along with Archie Campbell and Anant Narlikar. In fact it was Jan's enthusiasm for the proposed course of research that helped convince David that he should follow Professor Alan Cottrell's suggestion to apply metallurgical methodology to the study of the factors that controlled critical current density in the type II superconductors that were then under development for applications in magnets. Competing theories for the critical current density at that time were fine filaments or `Mendelssohn Sponge' versus the pinning of Abrikosov quantized vortices. The results of the group's work, to which Jan made a major contribution, came down heavily in favour of the latter theory. Jan's outstanding characteristic was his

  9. Impacto vocal de professores Teachers' vocal impact

    Directory of Open Access Journals (Sweden)

    Adriana Ricarte

    2011-08-01

    Full Text Available OBJETIVO: analisar o impacto vocal nas atividades diárias em professores do ensino médio. Correlacionar os achado da auto-percepção do problema vocal com os aspectos: efeitos no trabalho, na comunicação diária, na comunicação social e na sua emoção. MÉTODOS: a amostra foi constituída por 107 professores, sendo 86 com queixa e 21 sem queixa, selecionados em escolas da rede particular de ensino de Maceió-AL. Cada professor respondeu individualmente o protocolo Perfil Participação em Atividades Vocais na presença da pesquisadora, assinalando suas respostas em uma escala visual que varia de 0 a 10. O protocolo é composto por 28 questões com a presença integrada em cinco aspectos englobados para avaliar a qualidade de vida e o resultado de tratamentos vocais. O protocolo oferece, ainda, dois escores adicionais: pontuação de limitação nas atividades (PLA e de restrição de participação (PRP. RESULTADOS: na comparação dos grupos com e sem queixa vocal foram verificados que todos os resultados foram estatisticamente significantes (pPURPOSE: to analyze the vocal impact in the daily activities on high-school teachers. Correlate the finding of the auto-perception on the vocal problem with the following aspects: effects in the work, daily communication, social communication and, its emotion METHODS: the sample consisted of 107 teachers, 86 with and 21 with no complaint, selected from private teaching schools in Maceió-AL. Each teacher answered individually the Protocol for Voice Activity Participation Profile in the presence of the researcher, noting their responses on a visual scale ranging from 0 to 10. The protocol is composed of 28 questions with the presence integrated in five aspects to evaluate the quality of life and the result of vocal treatments. The protocol offers, still, two additional scores: punctuation of limitation in the activities (PLA and restriction of participation (PRP. RESULTS: comparing the groups with

  10. Before itard: intellectual disability and the enlightened voice of Daniel Defoe.

    Science.gov (United States)

    Smith, J David; Polloway, Edward A

    2014-12-01

    Although positive regard for the needs of people with disabilities was apparently uncommon by many accounts prior to the 20(th) century, this may be a misconception of history. There were likely many people who responded to the needs of their family members and others in need of assistance because of their disablities, and their physical and emotional proximity. This, however, if so, is not easily discernable in historical records. Few and rare voices raised that endeavored to inform and inspire others toward humane treatment and educational interventions for people with disabilities have been documented. This rarity was particulary true for those considered to have an intellectual disability. Evidence of advocacy in disbility history are difficult to find. When found they have been embraced as critical to understanding the development of the field of developmental disabilities. A famous example is the work of Jean Itard. The proposals of the well-known author, Daniel Defoe, however, are also notable for his forward-thinking writing as it related to how society should respond to the needs of people with disabilities. A review of his work provides important examples of a philosophy of advocacy and education that preceded the work of Itard by approximately 75 years but that has rarely been acknowledged. This manuscript highlights and discusses several of these important works and provides a context for Defoe's contributions.

  11. La funzione testuale secondo Daniel Dubuisson. Fondamenti di etica letteraria in Anthropologie poétique

    Directory of Open Access Journals (Sweden)

    Mariangela Lopopolo

    2011-07-01

    Full Text Available Nei tempi di crisi che stiamo attraversando, l’interrogativo sul ruolo e sull’utilità della opere letterarie sembra proporsi con una certa insistenza e rinnovarsi anche nel nostro paese. A cercare di rispondergli, sono, in particolare, gli studi dei rapporti tra l’etica e la letteratura, tradizionalmente concentrati su contenuti testuali espliciti, messaggi e ideologie. Tali studi, però, specie di recente, hanno mostrato di sapersi rivolgere anche al testo letterario in quanto forma artistica autonoma e dunque libera. Nella libertà del testo, l’etica della letteratura ha, quindi, scorto responsabilità cognitive, educative nonché orientative dei testi nei confronti degli uomini. Svolgendo ricerche in una chiave antropologico-metafisica, Daniel Dubuisson ha individuato proprio la conoscenza, l’educazione e l’orientamento come costitutivi della funzione testuale in generale e ha riservato alla questione il libro Anthropologie poétique (1996. Questo contributo ripercorre alcuni punti del lavoro dell’antropologo e storico delle religioni francese, con l’intento di presentare fondamenti di un’etica letteraria che si segnala all’attenzione della teoria e della critica della letteratura.

  12. Perspectivas hermenêuticas do romance metaficcional Cordilheira, de Daniel Galera

    Directory of Open Access Journals (Sweden)

    Bianca Cardoso Batista

    2015-06-01

    Full Text Available Este artigo objetiva elucidar os conceitos e características da hermenêutica, segundo Alfredo Bosi e Richard Palmer, e da metaficção, segundo Linda Hutcheon, Patrícia Waugh e Gustavo Bernardo. A partir das considerações e do posicionamento hermenêutico adotado, será feita uma pesquisa acerca da vida e obra de Daniel Galera para entender o contexto no qual o livro Cordilheira foi escrito e também para que se possa obter uma interpretação aprofundada da obra. Nesta análise é possível identificar a metaficção que, segundo Linda Hutcheon, é uma “ficção sobre ficção”. Ao final do artigo pode-se concluir que o leitor que desconhece o posicionamento hermenêutico e a visão metaficcional não consegue captar o sentido do texto. A interpretação requer um leitor específico, empenhado e entregue à obra, por isso o texto metaficcional só se torna compreensível e, consequentemente, interessante, a um leitor mais preparado.

  13. Cryogenic near infrared spectropolarimeter for the Daniel K. Inouye Solar Telescope

    Science.gov (United States)

    Fehlmann, Andre; Giebink, Cynthia; Kuhn, Jeffrey R.; Messersmith, Ernesto J.; Mickey, Donald L.; Scholl, Isabelle F.; James, Don; Hnat, Kirby; Schickling, Greg; Schickling, Richard

    2016-08-01

    The Cryogenic Near Infrared Spectropolarimeter for the Daniel K Inouye Solar Telescope is designed to measure polarized light from 0.5 to 5 μm. It uses an almost all reflective design for high throughput and an R2 echelle grating to achieve the required resolution of up to R = 100,000. The optics cooled to cryogenic temperatures reduce the thermal background allowing for IR observations of the faint solar corona. Both the spectrograph and its context imager use H2RG detector arrays with a newly designed controller to allow synchronized exposures at frame rates up to 10 Hz. All hardware has been built and tested and the key components met their design goals. 1) The cryogenic system uses mechanical closed cycle coolers which introduce vibrations. Our design uses a two stage approach with a floating mounting disk and flexible cold links to reduce these. The vibration amplitudes on all critical stages were measured and are smaller than 1μm. 2) The grating stage of the spectrograph uses a double stack of harmonic drives and an optical encoder to provide sub-arcsecond resolution and a measured repeatability of better than 0.5 arcsec.

  14. De temperamentis disputatio medica (1593 – a forgotten work of Daniel Naborowski

    Directory of Open Access Journals (Sweden)

    Agnieszka Raubo

    2015-12-01

    Full Text Available The article describes a forgotten work of Daniel Naborowski – “De temperamentis disputatio medica” (1593. Naborowski was a poet who lived at the turn of the 17th century and the work considered here is the result of his medical studies in Switzerland. The article addresses the poet’s scholarly interests, but first and foremost, it focuses on the subject of the research – the theory of temperaments. With ancient lineage and extremely popular in the sixteenth century, the theory was most frequently presented in the contexts of physiognomy, astrology and the lesions that were conditioned by the theory, yet in Naborowski’s work, it gained a new, solely theoretical perspec-tive. It was also concerned with the meticulous consideration of the systematics of temperaments (e.g. their differentiation – one was moderate and eight were merged, as well as their detailed division. The style of these considerations is characteristic for medical works of that period, and they constitute an interesting example of how practical issues in 16th and 17th century medicine were systematized. Furthermore, Naborowski’s considerations are a vivid example of permeable nature of disciplines – philosophy and medicine, and medicine with the broadly understood field of the humanities.

  15. Papeles de investigación: Notas sobre las melancolías y las perezas en La mafia rusa, de Daniel Link

    OpenAIRE

    Molina, Cristian

    2016-01-01

    El presente trabajo sobre los relatos de mercadoen Daniel Link y sus relaciones con el mercadoen el siglo xxi es parte de uno mayor respectodel problema en el Cono Sur. Aquí exploro losmatices que adquiere la melancolía y la perezaen La mafia rusa de Daniel Link, así como eluso del blog en tanto dispositivo de circulaciónque pone en juego una heterocronía temporalcontemporánea melancólica. Por ende, me de-tengo en los sentidos que adquiere la melanco-lía en la máquina narrativa de Daniel Link...

  16. In Memory of Professor Mohammad Hossein Salehi 1941-2014

    Directory of Open Access Journals (Sweden)

    Reza Bagheri

    2014-05-01

    Full Text Available Unfortunately, last winter, we lost one of the leaders of Radiotherpy-Oncology in Iran, Professor Mohammad Hossein Salehi. He was an excellent teacher, a supportive friend and an experienced physician.Professor Salehi was born on April 21, 1941 in Shirvan. After graduating from high school, he continued his education in Mashhad Medical School. In 1968 he completed Medical School and began the Residency Program of Radiology in Mashhad Medical School. Soon after, due to the lack of Radiotherapists in Mashhad and his eager to set up a Radiotherapy services in Mashhad, Dr. Salehi moved to England. He passed the Residency of Radiotherapy from 1972 to 1975 in the Royal Marsden Hospital, London and earned his Diploma in Medical Radiotherapy (D.M.R.T from the England Royal College and finished his fellowship ( F.R.C.R. After moving back to Iran in the same year and acquiring the Iranian National Board of Radiology, he started to work as Assistant Professor of Radiotherapy in Ghaem Hospital, Mashhad University of Medical Sciences, Iran. He arranged and established the first Radiotherapy Department in Mashhad in 1976. He was the Head of Radiotherapy-Oncology Department from 1976 to 2006.He was appointed as Associate Professor and after Professor of Radiotherapy-Oncology in 1985 and 1993, respectively. Professor Salehi was an active member of the Iranian National Board of Radiotherapy for 30 years. He was awarded as” The Best Professor “for 3 times.Beside his valuable clinical and educational activities, he was interested in medical research. He has published more than 20 articles and supervised about 25 theses. After 40 years continuous activity, Professor Salehi was retired in 2010. Unfortunately Professor Salehi passed away on January 23, 2014 after a four-year battle with metastatic colon cancer. His strength, wisdom, guidance and kindness will be missed by all who knew him.

  17. Interview with Professor Karl-Heinz Mehlan.

    Science.gov (United States)

    Neumann, H G

    1991-09-01

    Professor Karl-Heinz Mehlan, one of the founding fathers of German family planning in the post WWII area, celebrated his 75th birthday of July 18, 1991. The celebration took place in Rostock and Dr. Mehlan was in the best of health. As part of the occasion, Dr. Hans-Georg Neumann conducted an interview with Dr. Mehlan about the beginnings of family planning in what was then the Soviet occupied zone of Germany as well as its further development up to the present day. In the course of the interview Dr. Mehlan discussed the history of abortion in East Germany during the period of recovery immediately after WWII. He related his experiences working as a general practitioner in Calau and the committees he served on that were related to the study and delivery of abortion. During this time there were 80,000 recorded cases. After this he went to Berlin to the Institut fur Sozialmedizin der Chartie to write about the Calau experience. This was the 1st time that the abortion problem was discussed in German in a scientific context. He studied mortality, morbidity, and after effects.

  18. Lingering problems of currency and scope in Daniels's argument for a societal obligation to meet health needs.

    Science.gov (United States)

    Sachs, Benjamin

    2010-08-01

    Norman Daniels's new book, Just Health, brings together his decades of work on the problem of justice and health. It improves on earlier writings by discussing how we can meet health needs fairly when we cannot meet them all and by attending to the implications of the socioeconomic determinants of health. In this article I return to the core idea around which the entire theory is built: that the principle of equality of opportunity grounds a societal obligation to meet health needs. I point, first, that nowhere does Daniels say just what version of that principle he accepts. I then proceed to construct a principle on his behalf, based on a faithful reading of Just Health. Once we actually nail down the principle, I argue, we will find that there are two problems: it is implausible in itself, and it fails to ground a societal obligation to meet health needs.

  19. Editorial: A dedication to Professor Jan Evetts

    Science.gov (United States)

    Weber, Harald; Dew-Hughes, David; Campbell, Archie; Barber, Zoe; Somekh, Rob; Glowacki, Bartek

    2006-03-01

    A few days before the beginning of the 7th European Conference on Applied Superconductivity we learned that Professor Jan Evetts, a pioneer of superconductor research, a brilliant scientist, a wonderful person and a great personal friend, had passed away. We therefore decided to dedicate the 7th European Conference on Applied Superconductivity to the memory of Jan Evetts. The following citation is based on material provided by his former supervisor (D Dew-Hughes) and his closest co-workers in Cambridge. Professor Jan Edgar Evetts (1939-2005) Professor Jan Edgar Evetts (1939-2005) Jan Evetts passed away after losing his second battle with cancer on 24th August 2005. He made an outstanding series of contributions to the science of superconductivity and to the understanding of superconducting materials and was an indefatigable champion of the development of applications of superconductivity. The loss to the superconductivity community is incalculable, as attested by the many communications received from colleagues throughout the world. Jan was born on 31 March 1939, and attended the Dragon School in Oxford, and later Haileybury. He was awarded an exhibition to read Natural Sciences at Pembroke College, Cambridge. He entered the college in 1958 and took his BA degree in 1961. He then undertook a Certificate of Postgraduate Study in Physics under the supervision of Professor Neville Mott. He was the first student to undertake this newly-instituted course; the title of his thesis was `The Resistance of Transition Metals'. In 1962 he joined David Dew-Hughes' superconducting materials research group, along with Archie Campbell and Anant Narlikar. In fact it was Jan's enthusiasm for the proposed course of research that helped convince David that he should follow Professor Alan Cottrell's suggestion to apply metallurgical methodology to the study of the factors that controlled critical current density in the type II superconductors that were then under development for

  20. Professor M.K. Vainu Bappu (1927-82)

    Science.gov (United States)

    West, R. M.

    1982-12-01

    It was with great sadness that we received the news of the death, on 19 August 1982, of Professor M.K.V. Bappu, President of the International Astronomical Union and Director of the Indian Institute of Astrophysics, Bangalore, India. Professor Bappu was spending a few months with ESO in Munich, doing research within solar and stellar spectroscopy and at the same time preparing for the XVIIIth IAU General Assembly. A heart ailment necessitated a major surgical intervention, which was apparently successful. Howeyer, post-operative complications set in, and after a heroic struggle, assisted by the foremost medical expertise, Professor Bappu expired in the early evening of 19 August.

  1. Professor perceptions of college students with attention deficit hyperactivity disorder.

    Science.gov (United States)

    Vance, Teresa Ann; Weyandt, Lisa

    2008-01-01

    From April to June 2005, the authors investigated professor perceptions of college students with attention deficit hyperactivity disorder (ADHD). 253 participants completed the ADHD Beliefs Survey-Revised, a 40-question survey measuring professor perceptions of ADHD. Analysis of variance measured false and reasonable beliefs related to ADHD. Results indicated that professors with differing levels of education, years of teaching experience, colleges in the university or community college, previous experiences with a student with ADHD, and ADHD training did not differ significantly in perceptions regarding general ADHD knowledge or college students with ADHD.

  2. The priest Daniel Jordán Contreras in the East and Northeast Colombia, 1930-1948

    Directory of Open Access Journals (Sweden)

    Sergio Armando Cáceres Mateus

    2013-07-01

    Full Text Available This research is an approach to the life and the work of Priest Daniel Jordán Contreras (1899–1979, with the aim to describe and explain the politic and religious acts of presbytery in different parishes of the diocese of Pamplona in the period between 1930 and 1948, and give an input to the construction of the politic-religious history in the first half of twenty century in Colombia, specifically in the east and northeast region.

  3. Riesgos competitivos de muerte y equilibrio de Hardy-Weinberg en estudios de casos y controles sobre asociación entre genes y enfermedades Competing risks of death and Hardy-Weinberg equilibrium in case-control studies of gene-disease association

    OpenAIRE

    Javier Llorca; Dolores Prieto-Salceda; Onofre Combarros; Trinidad Dierssen-Sotos; José Berciano

    2005-01-01

    Objetivo: Estudiar el impacto de los riesgos competitivos sobre el equilibrio de Hardy-Weinberg y sus consecuencias en los estudios de casos y controles sobre la relación gen-enfermedades de comienzo tardío. Métodos: A partir de una población que, respecto de un determinado gen, se encuentre en equilibrio de Hardy-Weinberg al nacer, se deduce la composición genética cuando el gen está asociado con una enfermedad letal de aparición precoz, y sus consecuencias sobre una enfermedad de comienzo t...

  4. Kolm Eesti Robinsoni: Daniel Defoe romaan eesti tõlkes / Three Estonian Robinsons: Daniel Defoe’s Novel in Estonian Translation

    Directory of Open Access Journals (Sweden)

    Ene-Reet Soovik

    2012-06-01

    Full Text Available The article discusses three Estonian translations of Daniel Defoe’s Robinson Crusoe into Estonian with the focus on the completeness of the translated texts and the characterisation given to these in paratextual information. While there are several translations and versions of the tex t available in E stonian that have either used a mediating language or do not proceed directly from Defoe’s novel, three editions explicitly list Defoe’s English-language Robinson Crusoe as their source text. These are Rudolf Sirge’s translation from 1950 and two editions translated by Valter Rummel that appeared in 1984 (reprinted in 2001 and 2007, respectively. The article sets out to discover the main differences between the three editions and the possible reasons that may have triggered their publication in Estonia at those particular times. In order to approach the issues, a general framework derived from descriptive translation studies is employed with an emphasis on Gideon Toury’s chrestomatic treatment of translation norms. Thus an attempt is made to detect the preliminary translational norms regarding translation policy, particularly the choice of texts to be translated, as well as the matricial norms that concern the fullness of the translated text and are part of operational norms manifested in the translator’s decisions which, in two of the cases at hand, may also have been decisions made by the editor or the censor. Rudolf Sirge’s translation appeared at a time when Estonia had fairly recently been incorporated into the Soviet Union and there was a lack of children’s literature ideologically appreciated by the regime. This may account for the packaging of the book as a work with a strong didactic bent, while its primary audience was taken to be children and young adults for whom the protagonist served as an example of a hard-working and tenacious hero to be emulated by young Soviets. The target text has been considerably shortened as

  5. Dicósimo, Daniel y Simonassi, Silvia (comp., Trabajadores y empresarios en la Argentina del siglo XX: indagaciones desde la historia social

    Directory of Open Access Journals (Sweden)

    Valeria Ianni

    2013-01-01

    Full Text Available Dicósimo, Daniel y Simonassi, Silvia (comp., Trabajadores y empresarios en la Argentina del siglo XX: indagaciones desde la historia social, Prohistoria ediciones, Rosario, 2011 (194 págs..

  6. Special issue dedicated to Professor Johann M. Schepers

    Directory of Open Access Journals (Sweden)

    Gideon P De Bruin

    2006-04-01

    Full Text Available It is a great pleasure for me to have been associated with this special issue of the SA Journal of Industrial Psychology dedicated to Professor Johann M. Schepers. The purpose of the special issue is to honour Professor Schepers for his contributions to the development of Psychology and Industrial Psychology as empirical fields of study in South Africa. The contributors have worked with Professor Schepers as students or colleagues and share his academic interests. The articles reflect his areas of interest and employ analytic techniques taught and championed by him. We are grateful to Professor Schepers for his cooperation throughout this project. Thanks are due to all the contributors and referees.

  7. Three professors honored by Virginia Veterinary Medical Association

    OpenAIRE

    Douglas, Jeffrey S.

    2005-01-01

    The Virginia Veterinary Medical Association (VVMA) recently honored three professors from the Virginia-Maryland Regional College of Veterinary Medicine (VMRCVM) during its annual meeting at the Hotel Roanoke.

  8. The Effect of Professor's Attractiveness On Distance Learning Students

    Directory of Open Access Journals (Sweden)

    Jeanny Liu

    2015-07-01

    Full Text Available Technology enabled learning is becoming more popular and pervasive in education. While the effectiveness of distance learning versus traditional classroom education is strongly debated, human factors such as students’ perception of their professors can influence their desire to learn. This research examines the perceptual effect of attractive professors on business students enrolled in distance learning courses. This study expands on prior studies by testing whether the attractiveness of the professor matters to student learning within the context of online learning environment. A total of 122 online business students were surveyed. Our findings suggest that professor’s attractiveness has a statistically significant effect on student learning, motivation, and satisfaction. In addition, online students perceived attractive professors with more expertise as an instructor. Female students had higher motivation than male students. Furthermore, separate analysis indicated that attractiveness effects were stronger for participants over the age 46 when compared to other groups.

  9. Professor Nambu, string theory, and the moonshine phenomenon

    OpenAIRE

    Eguchi, Tohru

    2016-01-01

    I first recall the last occasion I met the late Professor Yoichiro Nambu, in a hospital in Osaka. I then present a brief introduction to a moonshine phenomenon in string theory that have recently come under investigation.

  10. DA Professor Honored for Teaching Excellence With Annual Hamming Award

    OpenAIRE

    Chagoya, Javier

    2017-01-01

    NPS Department of Defense Analysis Associate Professor Heather Gregg is the recipient of the 2017 Richard W. Hamming Annual Faculty Award for Achievement in Teaching, recognizing her exceptional work ... Read More

  11. INTRODUCTION: A TRIBUTE TO PROFESSOR MARJORIE L. GIRTH

    National Research Council Canada - National Science Library

    Armstead C Lewis

    2015-01-01

    ..., professional responsibility, and women's rights. Professor Girth joined the Buffalo Law School faculty in 1971 where she chaired the New York State Bar Association's Banking, Corporation and Business Law Section and was a member of the American Bar...

  12. Interview: Professor Andrew Feinberg speaks to Epigenomics.

    Science.gov (United States)

    Feinberg, Andrew

    2009-10-01

    Andrew Feinberg studied mathematics and humanities at Yale University (CT, USA) in the Directed Studies honors program, and he received his BA (1973) and MD (1976) from the accelerated medical program at Johns Hopkins University (MD, USA), as well as an MPH from Johns Hopkins (1981). He performed a postdoctoral fellowship in developmental biology at the University of California, San Diego (UCSD, CA, USA), clinical training in medicine and medical genetics at the University of Pennsylvania (PA, USA) and genetics research with Bert Vogelstein at Johns Hopkins, discovering altered DNA methylation in human cancer. Dr Feinberg continued to perform seminal work in cancer epigenetics as a Howard Hughes investigator at the University of Michigan (MI, USA), discovering human imprinted genes and loss of imprinting in cancer, and the molecular basis of Beckwith-Wiedemann syndrome. He returned to John Hopkins in 1994 as King Fahd Professor of Medicine, Molecular Biology & Genetics and Oncology, and he holds an Adjunct Professorship at the Karolinska Institute in Sweden. Dr Feinberg is Director of the Center for Epigenetics, a National Human Genome Research Institute-designated Center of Excellence in Genome Sciences. The Center is pioneering genome-scale tools in molecular, statistical and epidemiological epigenetics, and is applying them to the study of cancer, neuropsychiatric disease and aging. As part of the center, Dr Feinberg has organized a highly innovative program to bring gifted minority high-school students into genetics and genomics. Dr Feinberg has also invented a number of widely used molecular tools, including random priming. His honors include election to the American Society for Clinical Investigation, the Association of American Physicians, the Institute of Medicine of the National Academy of Sciences, and the American Academy of Arts and Sciences, as well as membership on the ISI most-cited authors list, a MERIT Award of the National Cancer Institute, a

  13. Participant compliance to a six‐month traditional and modified Daniel Fast

    Directory of Open Access Journals (Sweden)

    Richard Bloomer

    2014-09-01

    Full Text Available Background: We have previously reported multiple health benefits in individuals following the Christian-based fasting protocol known as the Daniel Fast (DF. However, our prior work has involved only short-term (21-day assessments. For dietary modification to have a profound impact on health, compliance to the dietary plan must be established for the long-term. Materials and Methods We determined the 6-month compliance to a traditional (vegan DF (n=12, as well as a modified DF (n=9; allowing for the inclusion of small amounts of meat and milk in healthy individuals. Participants completed diet records during the study period and also rated their overall compliance to the assigned dietary plan. Results Compliance to both dietary plans proved to be satisfactory (approximately 80% in the 6th month; 85% in the 3rd month and 95% during the 3rd week. It is noteworthy that it did not show any major differences between groups. Body weight, from baseline toward month 6, saw a decline in participants assigned to both the traditional DF (79.6±5.3 to 75.5±5.5 kg and the modified DF (80.4±8.0 to 74.3±6.5 kg. Conclusion These data indicated that both the traditional and modified DF, which involve ad libitum (Latin for “at liberty” feeding, are realistic for individuals to comply with over a period of several months. Such compliance is associated with a weight loss of approximately 5-8% of the body mass and considering the multi-faceted health benefits of this particular dietary approach, it may result in worthy improvements in overall health. Additional studies of the long-term health implications of this fasting method are also required.

  14. A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women

    Directory of Open Access Journals (Sweden)

    Canale Robert E

    2011-03-01

    Full Text Available Abstract Background Dietary modification via both caloric and nutrient restriction is associated with multiple health benefits, some of which are related to an improvement in antioxidant status and a decrease in the production of reactive oxygen species. The Daniel Fast is based on the Biblical book of Daniel, is commonly partaken for 21 days, and involves food intake in accordance with a stringent vegan diet. The purpose of the present study was to determine the effect of a 21 day Daniel Fast on biomarkers of antioxidant status and oxidative stress. Methods 43 subjects (13 men; 30 women; 35 ± 1 yrs; range: 20-62 yrs completed a 21 day Daniel Fast following the guidelines provided by investigators. Subjects reported to the lab in a 12 hour post-absorptive state both pre fast (day 1 and post fast (day 22. At each visit, blood was collected for determination of malondialdehyde (MDA, hydrogen peroxide (H2O2, nitrate/nitrite (NOx, Trolox Equivalent Antioxidant Capacity (TEAC, and Oxygen Radical Absorbance Capacity (ORAC. Subjects recorded dietary intake during the 7 day period immediately prior to the fast and during the final 7 days of the fast. Results A decrease was noted in MDA (0.66 ± 0.0.03 vs. 0.56 ± 0.02 μmol L-1; p = 0.004, while H2O2 demonstrated a trend for lowering (4.42 ± 0.32 vs. 3.78 ± 0.21 μmol L-1; p = 0.074. Both NOx (18.79 ± 1.92 vs. 26.97 ± 2.40 μmol L-1; p = 0.003 and TEAC (0.47 ± 0.01 vs. 0.51 ± 0.01 mmol L-1; p = 0.001 increased from pre to post fast, while ORAC was unchanged (5243 ± 103 vs. 5249 ± 183 μmol L-1 TE; p = 0.974. As expected, multiple differences in dietary intake were noted (p Conclusion Modification of dietary intake in accordance with the Daniel Fast is associated with an improvement in selected biomarkers of antioxidant status and oxidative stress, including metabolites of nitric oxide (i.e., NOx.

  15. Daniel Merro Johnston: el autor y el intérprete. Le Corbusier y Amancio Williams en la Casa Curutchet [Reseña

    OpenAIRE

    Torres Cueco, Jorge

    2011-01-01

    Reseña del libro "El autor y el intérprete. Le Corbusier y Amancio Williams en la Casa Curutchet" de Daniel Merro Johnston. Torres Cueco, J. (2011). Daniel Merro Johnston: el autor y el intérprete. Le Corbusier y Amancio Williams en la Casa Curutchet [Reseña]. Proyecto, Progreso, Arquitectura. (5):134-135. http://hdl.handle.net/10251/45880 Senia 134 135 5

  16. University Pedagogy for Assistant Professors at Aalborg University (Part 1)

    DEFF Research Database (Denmark)

    Kolmos, Anette; Krogh, Lone

    2003-01-01

    The article describes a course for assistant professors within the University Teacher Education at Aalborg University. The course focus is to develop knowledge, skills and methods from within the didactic, pedagogical, and learning theory-based fields.......The article describes a course for assistant professors within the University Teacher Education at Aalborg University. The course focus is to develop knowledge, skills and methods from within the didactic, pedagogical, and learning theory-based fields....

  17. Sex and Science: How Professor Gender Perpetuates the Gender Gap

    OpenAIRE

    Scott E. Carrell; Marianne E. Page; West, James E.

    2009-01-01

    Why aren't there more women in science? Female college students are currently 37 percent less likely than males to obtain a bachelor's degree in science, technology, engineering, and math (STEM), and comprise only 25 percent of the STEM workforce. This paper begins to shed light on this issue by exploiting a unique dataset of college students who have been randomly assigned to professors over a wide variety of mandatory standardized courses. We focus on the role of professor gender. Our resul...

  18. Emotional exhaustion and burnout among medical professors; a nationwide survey

    OpenAIRE

    Joeri K Tijdink; Vergouwen, Anton CM; Yvo M Smulders

    2014-01-01

    Background Although job-related burnout and its core feature emotional exhaustion are common among medical professionals and compromise job satisfaction and professional performance, they have never been systematically studied in medical professors, who have central positions in academic medicine. Methods We performed an online nationwide survey inviting all 1206 medical professors in The Netherlands to participate. They were asked to fill out the Maslach Burnout Inventory, a ‘professional en...

  19. The Effect of Professor's Attractiveness On Distance Learning Students

    OpenAIRE

    Jeanny Liu; Stella D. Tomasi

    2015-01-01

    Technology enabled learning is becoming more popular and pervasive in education. While the effectiveness of distance learning versus traditional classroom education is strongly debated, human factors such as students’ perception of their professors can influence their desire to learn. This research examines the perceptual effect of attractive professors on business students enrolled in distance learning courses. This study expands on prior studies by testing whether the attractiveness of the ...

  20. John Howard Marsden (1803–1891 First Disney Professor of Archaeology at the University of Cambridge 1851–1865

    Directory of Open Access Journals (Sweden)

    Michael Leach

    2007-05-01

    Full Text Available Although there were ten chairs of archaeology at universities in Germany, and one in France, by the mid-nineteenth century, in Great Britain it was the amateur societies and museums (the British Museum in particular that encouraged the study of this subject. In 1851 John Disney established the first university chair in Great Britain at Cambridge University. His proposal was initially received with considerable caution by the governing body of the university, and was only accepted by the narrowest margin of eight votes to seven. His agreement with the University of Cambridge stipulated that six lectures a year should be given on the subject of ‘Classical, Medieval, and other Antiquities, the Fine Arts and all matters and things connected therewith’ (Clark 1904, 222–225. However university archaeology was slow to establish its academic credibility nationally, and it was more than thirty years before Oxford University established its chair of classical archaeology. The Cambridge Board of Anthropological Studies, which included instruction in prehistoric archaeology, was not created until 1915, and as late as 1945 there were still only a few university lecturers in archaeology in Great Britain. It was not until 1946 that Oxford University appointed a Professor of Prehistoric Archaeology (Wilson 2002, 153; Daniel 1976, 6–12; Smith 2004, 4–5, 53–54.

  1. Exemplary Chinese University Professors: Qualities and Impact on Students

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    Eugene P. Kim

    2016-03-01

    Full Text Available This study focuses on the qualities of Chinese university professors as perceived by their students and the effects of those qualities on student learning and motivation. Specifically, what qualities and personal characteristics do Chinese university students attribute to their favorite and least favorite professors, and how do those qualities and characteristics affect Chinese university students? Out of 280 students surveyed from three different universities, 226 surveys were completed, returned and included in the final analysis (response rate of 80.7%. The research found that Chinese students favored professors who are entertaining, who help them learn more and who provide them with helpful feedback on their assignments. Students disfavor professors who are boring, arrogant and do not provide helpful feedback or help them learn more. Linear regressions revealed a connection between high quality professors and student learning and motivation. Along with other studies, this research provides evidence that effective university professors are those who not only possess expertise in their fields, but in addition are engaging, student-focused and able to build rapport with their students.

  2. Forecasting the Student-Professor Matches That Result in Unusually Effective Teaching

    Science.gov (United States)

    Gross, Jennifer; Lakey, Brian; Lucas, Jessica L.; LaCross, Ryan; Plotkowski, Andrea R.; Winegard, Bo

    2015-01-01

    Background: Two important influences on students' evaluations of teaching are relationship and professor effects. Relationship effects reflect unique matches between students and professors such that some professors are unusually effective for some students, but not for others. Professor effects reflect inter-rater agreement that some professors…

  3. Cálculo de frecuencias alélicas y equilibrio de Hardy-Weinberg en Genética de poblaciones.

    OpenAIRE

    Cross, Ismael; Rebordinos, Laureana

    2012-01-01

    La hoja de cálculo programada permite usarla de manera sencilla en clases prácticas de Genética de poblaciones a modo de herramienta de apoyo, permitiendo calcular las frecuencias alélicas observadas, las genotípicas esperadas y el equilibrio de Hardy-Weinberg a partir de unos datos de genotipado de un marcador codominante con un máximo de 4 alelos.

  4. Efficient designs of gene-environment interaction studies: implications of Hardy-Weinberg equilibrium and gene-environment independence.

    Science.gov (United States)

    Chen, Jinbo; Kang, Guolian; Vanderweele, Tyler; Zhang, Cuilin; Mukherjee, Bhramar

    2012-09-28

    It is important to investigate whether genetic susceptibility variants exercise the same effects in populations that are differentially exposed to environmental risk factors. Here, we assess the power of four two-stage case-control design strategies for assessing multiplicative gene-environment (G-E) interactions or for assessing genetic or environmental effects in the presence of G-E interactions. We considered a di-allelic single nucleotide polymorphism G and a binary environmental variable E under the constraints of G-E independence and Hardy-Weinberg equilibrium and used the Wald statistic for all tests. We concluded that (i) for testing G-E interactions or genetic effects in the presence of G-E interactions when data for E are fully available, it is preferable to ascertain data for G in a subsample of cases with similar numbers of exposed and unexposed and a random subsample of controls; and (ii) for testing G-E interactions or environmental effects in the presence of G-E interactions when data for G are fully available, it is preferable to ascertain data for E in a subsample of cases that has similar numbers for each genotype and a random subsample of controls. In addition, supplementing external control data to an existing case-control sample leads to improved power for assessing effects of G or E in the presence of G-E interactions. Copyright © 2012 John Wiley & Sons, Ltd.

  5. [Influential factors of Hardy-Weinberg equilibrium on the study of association between gene polymorphism and disease].

    Science.gov (United States)

    Chen, A-qun; Zang, Jing; Feng, Yun-xia; Wang, Kai-juan

    2009-11-01

    According to the data collected from gastric cancer families comparative study, the influence factors of Hardy-Weinberg (H-W) equilibrium in the association studies of gene polymorphism and disease were analyzed to reveal the reasons that affecting the equilibrium deviation in the group. Varieties of risk genotype for gastric cancer were analyzed and detected with H-W equilibrium, genetic linkage disequilibrium analysis and Cochran-Armitage trend test. (1) Significant deviations from H-W equilibrium were observed in IL-1B-31, IL-1B-511, IL-1RN and TNF-A-308 of the cases and controls (P < 0.01). MIF-173 tended to be equilibrium in the population. (2) Deviations from expectations of phenotypes combination probability were observed in two-site H-W chi(2) tests (P < 0.01). (3) The Cochran-Armitage trend test showed that distribution of IL-1B-511 and IL-1RN were significantly different (P < 0.05), suggesting that population stratification might have existed in the group. (1) Affected by frequency-dependent selection, under the combination of linkage disequilibrium, mutations and interaction, genotype frequency of IL-1B-31, IL-1B-511, IL-1RN and TNF-A-308 showed deviation from H-W equilibrium in population. (2) Two-site genetic equilibrium test model seemed better to reflect the differences of phenotypic combination fitness. (3) Population stratification was another factor to express the deviation from H-W equilibrium.

  6. Bayes factor based on the trend test incorporating Hardy-Weinberg disequilibrium: more power to detect genetic association.

    Science.gov (United States)

    Xu, Jinfeng; Yuan, Ao; Zheng, Gang

    2012-07-01

    In the analysis of case-control genetic association, the trend test and Pearson's test are the two most commonly used tests. In genome-wide association studies (GWAS), Bayes factor (BF) is a useful tool to support significant P-values, and a better measure than P-value when results are compared across studies with different sample sizes. When reporting the P-value of the trend test, we propose a BF directly based on the trend test. To improve the power to detect association under recessive or dominant genetic models, we propose a BF based on the trend test and incorporating Hardy-Weinberg disequilibrium in cases. When the true model is unknown, or both the trend test and Pearson's test or other robust tests are applied in genome-wide scans, we propose a joint BF, combining the previous two BFs. All three BFs studied in this paper have closed forms and are easy to compute without integrations, so they can be reported along with P-values, especially in GWAS. We discuss how to use each of them and how to specify priors. Simulation studies and applications to three GWAS are provided to illustrate their usefulness to detect nonadditive gene susceptibility in practice. © 2012 The Authors Annals of Human Genetics © 2012 Blackwell Publishing Ltd/University College London.

  7. An unconditional exact test for the Hardy-Weinberg equilibrium law: sample-space ordering using the Bayes factor.

    Science.gov (United States)

    Montoya-Delgado, L E; Irony, T Z; de B Pereira, C A; Whittle, M R

    2001-06-01

    Much forensic inference based upon DNA evidence is made assuming that the Hardy-Weinberg equilibrium (HWE) is valid for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, each having advantages and limitations. The limitations become more obvious when testing for deviation within multiallelic DNA loci is attempted. Here we present an exact test for HWE in the biallelic case, based on the ratio of weighted likelihoods under the null and alternative hypotheses, the Bayes factor. This test does not depend on asymptotic results and minimizes a linear combination of type I and type II errors. By ordering the sample space using the Bayes factor, we also define a significance (evidence) index, P value, using the weighted likelihood under the null hypothesis. We compare it to the conditional exact test for the case of sample size n = 10. Using the idea under the method of chi(2) partition, the test is used sequentially to test equilibrium in the multiple allele case and then applied to two short tandem repeat loci, using a real Caucasian data bank, showing its usefulness.

  8. Fluor Daniel Hanford implementation plan for DOE Order 5480.28, Natural phenomena hazards mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Conrads, T.J.

    1997-09-12

    Natural phenomena hazards (NPH) are unexpected acts of nature that pose a threat or danger to workers, the public, or the environment. Earthquakes, extreme winds (hurricane and tornado), snow, flooding, volcanic ashfall, and lightning strikes are examples of NPH that could occur at the Hanford Site. U.S. Department of Energy (DOE) policy requires facilities to be designed, constructed, and operated in a manner that protects workers, the public, and the environment from hazards caused by natural phenomena. DOE Order 5480.28, Natural Phenomena Hazards Mitigation, includes rigorous new natural phenomena criteria for the design of new DOE facilities, as well as for the evaluation and, if necessary, upgrade of existing DOE facilities. The Order was transmitted to Westinghouse Hanford Company in 1993 for compliance and is also identified in the Project Hanford Management Contract, Section J, Appendix C. Criteria and requirements of DOE Order 5480.28 are included in five standards, the last of which, DOE-STD-1023, was released in fiscal year 1996. Because the Order was released before all of its required standards were released, enforcement of the Order was waived pending release of the last standard and determination of an in-force date by DOE Richland Operations Office (DOE-RL). Agreement also was reached between the Management and Operations Contractor and DOE-RL that the Order would become enforceable for new structures, systems, and components (SSCS) 60 days following issue of a new order-based design criteria in HNF-PRO-97, Engineering Design and Evaluation. The order also requires that commitments addressing existing SSCs be included in an implementation plan that is to be issued 1 year following the release of the last standard. Subsequently, WHC-SP-1175, Westinghouse Hanford Company Implementation Plan for DOE Order 5480.28, Natural Phenomena Hazards Mitigation, Rev. 0, was issued in November 1996, and this document, HNF-SP-1175, Fluor Daniel Hanford

  9. Dedication to Professor Hannspeter Winter (1941 2006): Dedication to Professor Hannspeter Winter (1941 2006)

    Science.gov (United States)

    McCullough, Bob

    2007-03-01

    Professor H Winter. It was with great sadness that we learnt of the death of colleague and friend Professor Hannspeter Winter in Vienna on the 8 November 2006. In memory of him and the contribution he made both to our conference and to the field of the physics of highly charged ions we dedicate these proceedings. Hannspeter was one of our distinguished invited speakers at HCI2006 and gave a talk on the status of the ITER programme. His invited paper on the subject is included in these proceedings. Hannspeter will be particularly remembered for his pioneering work on ion-surface interactions that, together with his colleagues at the Vienna University of Technology (TUW), has stimulated a worldwide experimental and theoretical interest in this field. He was appointed Director of the Institut fuer Allgemeine Physik at TUW in 1987 and using both his scientific and management skills has made it one of the leading university physics laboratories in the world. His research publications, of which there are 270, have inspired many others to work in the field of atomic and plasma physics. He was also a great European playing a major role in the EURATOM fusion programme, the European Physical Society and the International Union of Pure and Applied Physics and was an evaluator and advisory board member for many national and international institutions. Hannspeter was also an interesting and friendly social companion with interests in current affairs, music and fine wines and will be greatly missed both on a scientific and social level. Our condolences go to his wife Renate, son Dorian and his relatives. R W McCullough Co-chair HCI2006

  10. Professor-psicopedagogo: o que este profissional faz na escola

    Directory of Open Access Journals (Sweden)

    Caroline Andrea Pottker

    Full Text Available Este estudo teve como objetivo identificar o porquê da presença do professor-psicopedagogo nas escolas e qual a função que este desempenha dentro delas, bem como, suas implicações no processo ensino-aprendizagem. Para tanto, foram entrevistados dez professores-psicopedagogos, pertencentes a cinco escolas localizadas no Estado do Paraná. Os resultados apontaram que o cargo de professor-psicopedagogo foi ocupado por professores que tinham o título de especialista em Psicopedagogia, os quais passaram a realizar avaliações psicopedagógicas dos alunos com dificuldades de aprendizagem. Segundo a maioria desses profissionais, uma de suas funções constitui-se em auxiliar o professor que apresenta em sala de aula alunos com dificuldades de aprendizagem, assim como tentar compreender o porquê de estes alunos não estarem aprendendo, sobretudo, ajudá-los na reversão desta problemática. Concluímos que a atuação deste profissional nestas escolas pouco tem contribuído para resolução das dificuldades de aprendizagem, pois centram-se no indivíduo e não no processo ensino-aprendizagem.

  11. El papel de la evolución en la teoría de Daniel Dennett

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    Colomina Almiñana, Juan José

    2004-09-01

    Full Text Available Tal vez la idea más controvertida de la filosofía de Daniel C. Dennett sea ésta: los seres humanos no son más que mecanismos dotados de intencionalidad derivada configurada por la evolución de las especies. Esto ha sido considerado por algunos como una afrenta porque relega al humano al estatus de simple artefacto: las acciones del ser humano no responden a sus propios intereses sino que se ven programados por «agentes internos especializados para recibir la información disponible en la periferia del cuerpo» que constituyen.…

  12. Aportes a la iconografía de Daniel Carrión García

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    Ricardo Iván Álvarez Carrasco

    2012-10-01

    Full Text Available Este artículo tiene como propósito brindar aportes novedosos e inéditos acerca de la iconografía de Daniel Carrión García (1857-1885, héroe y mártir de la medicina peruana, basados en evidencia material, demostrando que uno de los dos retratos que le son atribuidos corresponde al fotógrafo Rafael Castillo, quien trabajó en Lima entre las décadas de 1860 y 1890.

  13. Imaginarios de la migración/Migraciones del imaginario: “Ausencia” de Daniel Alarcón

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    Pamela Tala

    2011-06-01

    Full Text Available This article explores the characteristics adopted by the discourse of the migrant subject in the story "Ausencia" (Absence by the Peruvian writer Daniel Alarcón. Since the verification of a nomadic subject, it examines the re- articulation of the notions of territory, center / periphery and the confrontation with the "other." As a result of the analysis of these issues, we conclude that this narrative by Alarcón offers no relief to the subject from a dialectical synthesis of his identity; on the contrary, it leaves him suspended in an unfinished and amazed identification process.

  14. Cierre primario en trauma de colon. Hospital Nacional Daniel Alcides Carrión, 2009-2014

    OpenAIRE

    Tagle Carbajal, Gustavo

    2015-01-01

    Identifica si los factores pronósticos tradicionales para el cierre primario influyen en la evolución y complicaciones de los pacientes con trauma penetrante de colon en el Hospital Daniel Alcides Carrión - Callao, durante el periodo 2009- 2014. Material y Métodos: Es un estudio observacional, retrospectivo, transversal y descriptivo. Variables estudiadas: Edad, sexo, procedencia, horas de evolución previas a la cirugía, mecanismo del trauma, región abdominal afectada, segmento de colon...

  15. MISE-EN-ABYME: THE PORTRAIT OF REMBRANDT IN THE CONFESSIONAL NOVEL ‘DANIEL MARTIN’ BY JOHN FOWLES (1977

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    Dzhumailo O.A.

    2013-03-01

    Full Text Available This article proposes the importance of mise-en-abyme inclusion into the artistic whole of the self-reflexive confessional novel Daniel Martin (1977 by John Fowles. It is argued that Rembrandt’s late self-portrait provokes ideas for the novel reading and manifests itself as an emblem of artistic authenticity. Analytical reading of the psychological and existentialist scope of mise-en-abyme also focuses on playful use of self-reflexive means (metalepsis, short circuit, mirror leitmotif, fragmentality, stylization and other means. All these are aligned with the idea of confessional lack of closure.

  16. Henry Daniel Cogswell, DDS (1819-1900): a temperance advocate, philanthropist and builder of ice-water fountains.

    Science.gov (United States)

    Christen, A G; Theobald, M S; Christen, J A

    1999-07-01

    Henry Daniel Cogswell (Fig. 1), the second of five children, was born in Tolland, Connecticut on March 3, 1819. His father, George Washington Cogswell, was a general carpenter, architect and builder of moderate circumstances. In 1827, when Henry was eight, his mother died. The following year, Henry's father moved to Orwell, (Oswego County) New York, in hopes of improving his financial condition. Henry was left behind in the care of his paternal grandfather, who died several months later, leaving the 10-year old boy, stranded and forced to rely upon his own resources. (In those times, when families were separated, individual members had limited means of locating one another.)

  17. PROFESSOR DR. ION PIŞOTA (1925 – 2008

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    Liliana ZAHARIA

    2009-12-01

    Full Text Available Professor Ion Pişota was born on June 6, 1925, in Hrupiştea, a small settlement in Greek Macedonia, from where he and his family came to Romania in 1927, where he got Romanian citizenship. Between 1941 and 1945, he attended the Tulcea Boys High School and later on, in 1947 he entered the Faculty of Geology – Geography at the University of Bucharest, where he continued to excel until 1951, when he graduated. In the fall of 1950, he took up a tutor position in the field of Hydrolgy at the same faculty passing subsequently through all the stages of academic hierarchy until he became, in 1971, a University Professor. Even after he retired, in 1996, he continued his academic activity as a consultant professor within the same department and faculty that he served with passion and devotion for more than 50 years.

  18. Categorization of Quantum Mechanics Problems by Professors and Students

    CERN Document Server

    Lin, Shih-Yin

    2016-01-01

    We discuss the categorization of 20 quantum mechanics problems by physics professors and undergraduate students from two honors-level quantum mechanics courses. Professors and students were asked to categorize the problems based upon similarity of solution. We also had individual discussions with professors who categorized the problems. Faculty members' categorizations were overall rated higher than those of students by three faculty members who evaluated all of the categorizations. The categories created by faculty members were more diverse compared to the categories they created for a set of introductory mechanics problems. Some faculty members noted that the categorization of introductory physics problems often involves identifying fundamental principles relevant for the problem, whereas in upper-level undergraduate quantum mechanics problems, it mainly involves identifying concepts and procedures required to solve the problem. Moreover, physics faculty members who evaluated others' categorizations express...

  19. Faculty Agency in Applying for Promotion to Professor

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    Susan K. Gardner

    2017-02-01

    Full Text Available Aim/Purpose: In the United States, faculty who wish to pursue promotion to the rank of professor do so without clear guidance or structure. Even the timing of such a process is nebulous. As such, an individual engages in agentic action to pursue the rank. Background: This study examined the experiences of faculty members who chose to pursue the application process to be promoted to professor but were rejected or dissuaded. Methodology: Utilizing a case study of one institutional setting, we conducted 10 in-depth qualitative interviews. Contribution: Very little is known about the process of promotion to full professor in the U.S. and even less empirical research exists. This study advances knowledge of the process and the experiences of those undertaking it. Findings: We learned that cues from the social context greatly influenced these faculty members’ sense of agency.

  20. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  1. Aspectos gerais da formação de professores

    Directory of Open Access Journals (Sweden)

    Edson do Carmo Inforsato

    1996-08-01

    Full Text Available Este artigo, ancorado em estudos recentes e antigos, mostra o afastamento dos cursos de formação de professores em relação aos elementos que compõem a prática profissional docente. Favorável a uma aproximação efetiva com o contexto das práticas de sala de aula, o autor defende a idéia de uma formação de professores atrelada aos problemas e necessidades da prática docente no ensino formal de 1º e 2º graus.

  2. O papel do formador no processo reflexivo de professores

    OpenAIRE

    Altarugio Helena, M.

    2009-01-01

    Este trabalho pretende discutir as práticas e os discursos de uma formadora de professores de ciências, experiente e bem sucedida na formação inicial e continuada. Nossa hipótese é a de que, além dos conhecimentos e das técnicas, é na relação intersubjetiva construída entre a formadora e o grupo de professores, que se encontram os elementos que irão sustentar o processo de formação docente. A partir do modo singular da formadora de enfrentar sua tarefa educativa e lidar com as dificuldades do...

  3. Preditores da Síndrome de Burnout em professores

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    Mary Sandra Carlotto

    Full Text Available O objetivo deste estudo foi identificar os preditores da Síndrome de Burnout em 563 professores de instituições educacionais particulares da região metropolitana de Porto Alegre - RS. Foram utilizados um questionário elaborado para levantamento de variáveis demográficas e profissionais, o Maslach Burnout Inventory, o Job Diagnostic Survey e o Questionário de Satisfação no Trabalho S20/23. Os resultados evidenciam que variáveis relacionadas ao contexto laboral predominam no modelo explicativo de Burnout em professores em ambos os grupos.

  4. Apoio social e fatores associados com a disfonia em professores

    OpenAIRE

    Ceballos,Albanita Gomes da Costa de

    2009-01-01

    p. 1-68 Fatores relacionados com o ambiente e a organização do trabalho, além de fatores próprios do sujeito têm se mostrado associados ao adoecimento vocal de professores. O objetivo deste estudo foi analisar os fatores associados a disfonia nesta categoria profissional e investigar a contribuição do apoio social no processo de adoecimento vocal de professores. Foram pesquisados 476 docentes de escolas municipais de quatro regionais de educação da cidade de Salvador – Bahia. A coleta de d...

  5. Testing for Sufficient-Cause Gene-Environment Interactions Under the Assumptions of Independence and Hardy-Weinberg Equilibrium.

    Science.gov (United States)

    Lee, Wen-Chung

    2015-07-01

    To detect gene-environment interactions, a logistic regression model is typically fitted to a set of case-control data, and the focus is on testing of the cross-product terms (gene × environment) in the model. A significant result is indicative of a gene-environment interaction under a multiplicative model for disease odds. Based on the sufficient-cause model for rates, in this paper we put forward a general approach to testing for sufficient-cause gene-environment interactions in case-control studies. The proposed tests can be tailored to detect a particular type of sufficient-cause gene-environment interaction with greater sensitivity. These tests include testing for autosomal dominant, autosomal recessive, and gene-dosage interactions. The tests can also detect trend interactions (e.g., a larger gene-environment interaction with a higher level of environmental exposure) and threshold interactions (e.g., gene-environment interaction occurs only when environmental exposure reaches a certain threshold level). Two assumptions are necessary for the validity of the tests: 1) the rare-disease assumption and 2) the no-redundancy assumption. Another 2 assumptions are optional but, if imposed correctly, can boost the statistical powers of the tests: 3) the gene-environment independence assumption and 4) the Hardy-Weinberg equilibrium assumption. SAS code (SAS Institute, Inc., Cary, North Carolina) for implementing the methods is provided. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Losing balance: Hardy-Weinberg disequilibrium as a marker for recurrent loss-of-heterozygosity in cancer.

    Science.gov (United States)

    Wilkins, Katherine; LaFramboise, Thomas

    2011-12-15

    Identifying regions of loss-of-heterozygosity (LOH) in a tumor sample is a challenging problem. State-of-the-art computational approaches can infer LOH from single-nucleotide polymorphism (SNP) array data, but calling precise boundaries is complicated by normal-cell contamination and markers that are homozygous in the germline and therefore non-informative. More recently, the focus has shifted to pinpointing the loci recurrently affected by LOH events across multiple tumors. Recurrent LOH regions often harbor genes important for tumor suppression. Here, we propose a method that infers LOH rates across an entire sample set on an SNP-by-SNP basis. Our method achieves this by leveraging the straightforward principle that, by definition, LOH depletes heterozygotes, thereby disrupting Hardy-Weinberg equilibrium. We apply a statistical test for such LOH-influenced disruptions, and derive a maximum-likelihood estimator for the LOH rate based on the observed number of heterozygotes. This accounts for LOH in both its hemizygous deletion and copy-neutral forms, and does not make use of matched normal genotypes. Power simulations show high levels of sensitivity for the statistical test, and application to a control normal-tissue data set demonstrates a low false-discovery rate. We apply the method to three large publicly available tumor SNP array data sets, where it is able to localize tumor-suppressor gene targets of the LOH events. Inferred LOH rates are quite concordant across platforms/laboratories and between cell lines and tumors, but in a tumor type-dependent fashion. Finally, we produce rate estimates that are generally higher than previously published, and provide evidence that the latter are likely underestimates.

  7. Favorable cardio-metabolic outcomes following high carbohydrate intake in accordance with the Daniel Fast: A review of available findings

    Directory of Open Access Journals (Sweden)

    Richard Bloomer

    2017-03-01

    Full Text Available The Daniel Fast is a biblically inspired dietary program rich in carbohydrate, most closely resembling a vegan diet but with additional restrictions, including the elimination of processed foods, white flour products, preservatives, additives, sweeteners, caffeine, and alcohol. While no specific requirements are placed on the ingestion of specific percentages of macronutrients, the mean daily carbohydrate intake is by default approximately 60%, while protein and fat intake are 15% and 25%, respectively. Despite a relatively high carbohydrate intake, multiple favorable cardio-metabolic effects are noted when following the plan, in as few as three weeks. This includes improvements in HOMA-IR, which may be at least in part due to the lower glycemic load and high dietary fiber content of the foods consumed. Other notable changes include reductions in systemic inflammation, total and LDL-cholesterol, oxidative stress, blood pressure, and body weight/body fat. Short and moderate-term compliance to the program is excellent-better than most dietary programs, perhaps due to the ad libitum nature of this plan. This paper presents an overview of the Daniel Fast, a carbohydrate-rich dietary program, including relevant findings from both human and animal investigations using this dietary model.

  8. Women Professors of Educational Administration: A Profile and Salient Issues.

    Science.gov (United States)

    Short, Paula M.; And Others

    The purpose of this study is to assess the current status of women professors of educational administration. Research findings are reviewed and discussed in the areas of socialization of women and sex-role stereotyping, mentoring, and networking. A 37-item questionnaire addressed background information, graduate school experiences, first…

  9. [Professor TIAN Cong-huo's experience on clinical acupuncture].

    Science.gov (United States)

    Song, Shi-Yun; Wang, Yin

    2008-10-01

    Professor TIAN's experiences on acupuncture treatment of various difficult diseases with different acupuncture methods based on syndrome differentiation of different patients, for example, para-acupuncture for treatment of migraine, triple puncture at Dazhui (GV 14) for recurrent depression, lifting and thrusting point Shexiaxue for treatment of aphasia, electroacupuncture at Shuigou (GV 26) and Baihui (GV 20) for treatment of schizophrenia, etc. are introduced.

  10. Häbi, professor, teil on Gefilus kapis / Eve Kruuse

    Index Scriptorium Estoniae

    Kruuse, Eve,d1959-

    2008-01-01

    Tartu Ülikooli professor Marika Mikelsaar võitis läinud kuul koos kolleegidega (Tiiu Kullisaar, Epp Songisepp, Hedi Annuk ja Mihkel Zilmer) Soulis ülemaailmse naisleiutajate konkursil ME-3 bakteri avastamise ja probiootikuks arendamise eest kuldmedali

  11. Burnout Syndrome and Self-Efficacy Beliefs in Professors

    Science.gov (United States)

    García Padilla, Arlington Antonio; Escorcia Bonivento, Carla Vanessa; Perez Suarez, Blinis Sat

    The presence of the Burnout syndrome in professors may be regarded as a deterioration of their mental health with negative impacts on their job performance. It is known that teachers develop different activities in the areas of teaching, outreach and research. This study aims to analyze the relationship between the Burnout syndrome and…

  12. Communication professor examines media bias in president's speeches

    OpenAIRE

    Elliott, Jean

    2006-01-01

    Jim A. Kuypers, assistant professor of communication in the College of Liberal Arts and Human Sciences at Virginia Tech, reveals a disturbing world of media bias in his new book Bush's War: Media Bias and Justifications for War in a Terrorist Age (Rowman & Littlefield Publishers, Inc. 2006).

  13. A Comparison of Students' Perceptions of an Ideal Professor.

    Science.gov (United States)

    Gadzella, Bernadette M.; And Others

    A study was done of college students' current perceptions of the most and least important characteristics of an ideal professor. These perceptions were compared with findings from earlier studies, and differences among student groups (based on gender, college status, grade point average (GPA), and majors) were compared. The study surveyed 356…

  14. Analysis of an Instrument on a Quality Professor.

    Science.gov (United States)

    Lytton, Channon R.; Gadzella, Bernadette M.

    The reliability of the questionnaire, Students' Views of an Ideal Professor, was studied. Subjects were 86 students (35 males and 51 females) who were enrolled in psychology classes at a state university. Subjects included 34 freshmen, 27 sophomores, 20 juniors, 4 seniors, and 1 graduate. The questionnaire consists of 25 characteristics of a…

  15. University Professors and Teaching Ethics: Conceptualizations and Expectations

    Science.gov (United States)

    Dean, Kathy Lund; Beggs, Jeri Mullins

    2006-01-01

    After the spectacular ethical breaches in corporate America emerged, business school professors were singled out as having been negligent in teaching ethical standards. This exploratory study asked business school faculty about teaching ethics, including conceptualizations of ethics in a teaching context and opinions of the extent to which…

  16. Tribute to the legend Mr. Veterinary Public Health, Professor James ...

    African Journals Online (AJOL)

    The author was also destined during his Sabbatical Leave to have an interactive interview session with Prof James Steele after attending the 20th Annual James Steele lecture/ 99th birthday Dinner of Professor James Steele 4th and 6th April 2012 at the Texas School of Public Health, Houston, Texas, USA. The interview ...

  17. Postcards from a Road Trip to Innovation: One Professor's Sabbatical

    Science.gov (United States)

    Kelley, Todd R.

    2016-01-01

    Precious moments in life for an educator are taking time to reflect upon his or her teaching practices to evaluate effectiveness and overall impact. Often this reflection is a weekly if not a daily process for educators using a reflective practitioner model (SchÖn, 1983). For professors, many universities have opportunities for tenured faculty to…

  18. Humor and the Emeritus Professor: An Interview with Gene Roth

    Science.gov (United States)

    Vivona, Brian

    2015-01-01

    This essay is a compilation of several conversations with Dr. Gene Roth, Distinguished Teaching Professor Emeritus at Northern Illinois University. Dr. Roth is past President of the Academy of Human Resource Development, and although he is well known for his efforts in bringing humor into the field of HRD, he is not the same Gene Roth that played…

  19. An Examination of Assistant Professors' Project Management Practices

    Science.gov (United States)

    Alpert, Shannon Atkinson; Hartshorne, Richard

    2013-01-01

    Purpose: The purpose of this research was to identify factors that influence the use of project management in higher education research projects by investigating the project management practices of assistant professors. Design/methodology/approach: Using a grounded theory approach that included in-depth, semi-structured interviews with 22…

  20. Developing Student Character: Community College Professors Who Share Power

    Science.gov (United States)

    Humphreys, Connie K.

    2012-01-01

    This phenomenological study examined the definitions, values, and experiences of seven community college professors who have tried to promote student character development by sharing some of their power in the classroom. Power sharing is a participative gesture, and participative teachers can encourage students to become more engaged in their own…

  1. For Professors' Children, the Case for Home Schooling

    Science.gov (United States)

    Pannapacker, W. A.

    2005-01-01

    The number of families who home school their children is growing between five and 15% per year and it is believed that home schoolers outperform their public-educated peers, though critics believe that home schooling is a form of religious fanaticism and a means of avoiding diversity. A professor explains how he and his wife, home school their…

  2. "Women in Science" with Professor Jocelyn Bell Burnell

    Indian Academy of Sciences (India)

    2014-01-11

    January 11, 2014 | 11:30 am | Multimedia hall, New Physical Sciences Building. Chair, WiS panel of the IASc, Prof. Rohini Godbole, IISc will preside. “Women in Science”: an Interactive Discussion. Session with. Prof. Jocelyn Bell Burnell are happy to present. Prof. Dame Jocelyn Bell Burnell is currently a visiting Professor at ...

  3. The professor within the context of African Universities | Nenty ...

    African Journals Online (AJOL)

    It affirms that the professor is the soul of the university which itself is a world-wide liberal space for the development of the human intellect and genius. The paper further argues that when an individual has been able to satisfy the rigours of the professoriate, such an individual owes it as an obligation to impact positively ...

  4. Does Gender and Professional Experience Influence Students' Perceptions of Professors?

    Science.gov (United States)

    Tindall, Natalie T. J.; Waters, Richard D.

    2017-01-01

    Grounded in literature stemming from higher education research, this study examines how students evaluate public relations educators by gauging their perceptions of the professors' professional competency, professorial warmth, course difficulty, and industry connectivity. Using an experimental design, students (N = 303) from four U.S. universities…

  5. Professor GN Ramachandran's Contributions to X-ray Crystallography

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 10. Professor G. N. Ramachandran's Contributions to X-ray Crystallography. K Venkatesan. General Article Volume 6 Issue 10 October 2001 pp 8-15. Fulltext. Click here to view fulltext PDF. Permanent link:

  6. Ten Things Every Professor Should Know about Assessment

    Science.gov (United States)

    Wolf, Kenneth; Dunlap, Joanna; Stevens, Ellen

    2012-01-01

    This article describes ten key assessment practices for advancing student learning that all professors should be familiar with and strategically incorporate in their classrooms and programs. Each practice or concept is explained with examples and guidance for putting it into practice. The ten are: learning outcomes, performance assessments,…

  7. Professor-Student Rapport Scale: Six Items Predict Student Outcomes

    Science.gov (United States)

    Wilson, Janie H.; Ryan, Rebecca G.

    2013-01-01

    Rapport between students and teachers leads to numerous positive student outcomes, including attitudes toward the teacher and course, student motivation, and perceived learning. The recent development of a Professor-Student Rapport scale offers assessment of this construct. However, a Cronbach's [alpha] of 0.96 indicated item redundancy, and the…

  8. Dilemmas of a Newly Recruited Academic Qualified Professor: A Case

    Science.gov (United States)

    Agrawal, Anand

    2015-01-01

    This case describes the situation of a newly recruited academic professor who volunteered to teach a course on Research Methods to first-term MBA students in a practitioner-oriented case method Business School. Research Methods is a unique course due to its relevance not only in business but also across all graduate programs. Instructional and…

  9. Teaching the College "Nones": Christian Privilege and the Religion Professor

    Science.gov (United States)

    Riswold, Caryn D.

    2015-01-01

    Working with undergraduate students invites teachers into relationship and conversation with young people at a time when they are emerging as adults and forming their identities. Faith is one area of identity formation often attended to by scholars, college professors, and their institutions. But within that, little attention has been paid to…

  10. Identity Issues: Expatriate Professors Teaching and Researching in Qatar

    Science.gov (United States)

    Romanowski, Michael H.; Nasser, Ramzi

    2015-01-01

    Today, academics are more transient, working outside their home countries, than at any other time in the history of academics especially in the Arab World were there is great demand for faculty members educated in Western' culture and academia. However, many of these professors face considerable social, professional and academic challenges in…

  11. Reflections on Finally Becoming a Professor after Forty Years

    Science.gov (United States)

    Watkins, J. Foster

    2016-01-01

    I wrote this reflective piece in 1999 as I was assuming my first full-time position as a professor with limited administrative responsibilities at the University of Alabama at Birmingham (UAB). After 30-plus years in administrative roles in higher education that provided the opportunity to teach on a part-time basis only, I quickly became aware of…

  12. The rotor theories by Professor Joukowsky: Vortex theories

    DEFF Research Database (Denmark)

    Okulov, Valery L.; Sørensen, Jens Nørkær; Wood, David H.

    2015-01-01

    This is the second of two articles with the main, and largely self-explanatory, title "Rotor theories by Professor Joukowsky". This article considers rotors with finite number of blades and is subtitled "Vortex theories". The first article with subtitle "Momentum theories", assessed the starring ...

  13. Kant as a Professor: Some Lessons for Today's Intellectuals ...

    African Journals Online (AJOL)

    The thoughts of every great philosopher is measured and represented by the history of his social background. It is indeed, more appropriate particularly in the case of a great philosopher like Immanuel Kant to single out for special recognition the outstanding characteristics of his early life on his career as a professor of ...

  14. Reflections on the Scholarly Contributions of Professor David H. Jonassen

    Science.gov (United States)

    Reeves, Thomas C.; Lee, Chwee Beng; Hung, Woei

    2013-01-01

    The six papers in this special issue of "Computers and Education" honoring Professor David H. Jonassen are diverse in nature. They also reflect differing interpretations of the implications of Jonassen's work for research and development focused on instructional models and the factors influencing instruction as well as the directions for future…

  15. Championing Inclusion: An Interview with Professor Luanna Meyer

    Science.gov (United States)

    Bevan-Brown, Jill

    2012-01-01

    In May 2012, after a long and impressive career, Luanna Meyer retired from her role as Professor of Education and Director of the Jessie Hetherington Centre for Educational Research at Victoria University. The tributes paid at her retirement ceremony bear testament to a woman who is held in high esteem in the educational community. In this…

  16. On the Seminar of Professor Shulamit Kreitler in MSUPE

    Directory of Open Access Journals (Sweden)

    Fedorova A.I.

    2015-06-01

    Full Text Available From 9 to 15 of February, 2015 in Moscow state university of psychology and education hosted series of seminars of doctor of psychology Shulamit Kreitler. Dr. Kreitler is a professor of Tel-Aviv University, director of psychology studies center in Sheba medical center, Tel-Hashomer, Israel.

  17. On the Seminar of Professor Shulamit Kreitler in MSUPE

    OpenAIRE

    Fedorova A. I.; Scherbakova A.M.

    2015-01-01

    From 9 to 15 of February, 2015 in Moscow state university of psychology and education hosted series of seminars of doctor of psychology Shulamit Kreitler. Dr. Kreitler is a professor of Tel-Aviv University, director of psychology studies center in Sheba medical center, Tel-Hashomer, Israel.

  18. The Effect of Professor's Attractiveness on Distance Learning Students

    Science.gov (United States)

    Liu, Jeanny; Tomasi, Stella D.

    2015-01-01

    Technology enabled learning is becoming more popular and pervasive in education. While the effectiveness of distance learning versus traditional classroom education is strongly debated, human factors such as students' perception of their professors can influence their desire to learn. This research examines the perceptual effect of attractive…

  19. Career Vitality of Professors: A Cognitive Restructuring Model.

    Science.gov (United States)

    Bumpus, J. Frank

    An attributional model that conceptualizes the pressures that reduce professors' personal and career vitality is presented. The model is based primarily on the locus of control literature and especially the reformulated model of learned helplessness by Lynn Abramson, Martin Seligman, and John Teasdale. The analysis deals only with the cognitive…

  20. Could We Talk? Pragmatic Variations in Student-Professor Negotiations.

    Science.gov (United States)

    Biesenbach-Lucas, Sigrun; Weasenforth, Donald

    This study focuses on electronic office hour consultations and investigates the presence and organization of pragmatic elements associated with negotiating the completion and evaluation of coursework in the e-mail messages of 28 American and international students to an American professor. Findings indicate a lack of negotiation skills in the…

  1. [DR. Hanka Weinberg-Heruti: the pediatrician from Merchavia--the first woman-doctor 'Kibbutznik' in the Kibbutz Ha'artzi].

    Science.gov (United States)

    Shehory-Rubin, Zipora

    2015-07-01

    Dr. Hanka Weinberg-Heruti, a pediatrician at the Ha'Emek Hospital and a member of Kibbutz Merchavia is regarded in the history of medicine in Eretz Israel as the first female physician in the Kibbutz Ha'Artzi movement-Hashomer Hatsa'ir, and one of the founders of children's medicine in the country. Dr. Weinberg-Heruti was able to break the accepted norms of the period and prove "you could be both a hospital doctor and a loyal kibbutz member". This was far from simple for there was an iron rule in that kibbutz movement: "Every member must perform physical labour to build the kibbutz and to work in its framework. This principle is inviolable nor can one deviate from the norm". Dr. Weinberg-Heruti dared to break that rule and prove that a successful combination of both her purposes in life was possible. Thus, the aim of the article is twofold: to survey her unique position as hospital doctor and faithful 'kibbutznik', who dared to break the "holy" principle at the ideological roots of kibbutz life--that it was unthinkable for a member to refrain from physical labour. Secondly, to illuminate her medical career as pediatrician in Ha'Emek Hospital, and describe the innovations she introduced to the children's ward, survey her groundbreaking research, that examined the influence of the Beit Shean Valley climate on infant development. Her conclusions dramatically affected the treatment and upbringing of children in that climate, and were adopted not only in local kibbutzim but throughout the country.

  2. Refletindo sobre a relação professor-aluno em um grupo de professores do Esino Fundamental

    Directory of Open Access Journals (Sweden)

    Antônio dos Santos Andrade

    1999-06-01

    Full Text Available A partir das concepções de Donald Schön sobre a formação do professor como prático reflexivo, os princípios de trabalho com pequenos grupos, baseados nas concepções de J. L Moreno, foram utilizados com o objetivo de facilitar o processo de reflexão sobre suas práticas de sala de aula, com seis professores do Ensino Fundamental. Foram realizados nove encontros de 90 a 120 minutos de duração. Nas discussões, os casos dos alunos mais problemáticos quanto ao seu comportamento foram trazidos pelos professores e analisados pelo grupo a luz das concepções da Pragmática da Comunicação Humana. Como resultado destas discussões, os professores foram levados a considerar os aspectos mais latentes, e portanto significantes, de suas relações com os alunos. Estas reflexões conduziram a uma "resignificação" das mesmas, com efeitos surpreendentes sobre os comportamentos dos alunos.

  3. Why Did the Professor Cross the Road? How and Why College Professors Intentionally Use Humor in Their Teaching

    Science.gov (United States)

    Buckman, Karen Hildebrant

    2010-01-01

    College professors face many pressing challenges: staying current in their disciplines, becoming familiar with new technology, responding to national accountability issues, publishing scholarly research in their fields, and facilitating student learning in their classes. Teaching and learning are complex processes. Humor is a powerful…

  4. Yue Joseph Wang named Grant A. Dove Professor of Electrical and Computer Engineering

    OpenAIRE

    Owczarski, Mark

    2009-01-01

    Yue Joseph Wang, professor of electrical and computer engineering in the College of Engineering at Virginia Tech, has been named the Grant A. Dove Professor of Electrical and Computer Engineering by the Virginia Tech Board of Visitors.

  5. Maury Nussbaum reappointed as Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Maury Nussbaum, professor of industrial and systems engineering in the College of Engineering at Virginia Tech, has been reappointed as the Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering by the Virginia Tech Board of Visitors.

  6. Brian M. Kleiner receives Ralph H. Bogle Professor Fellowship in Industrial and Systems Engineering

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Brian M. Kleiner, professor of industrial and systems engineering in the College of Engineering at Virginia Tech, has been named the Ralph H. Bogle Professor Fellow in Industrial and Systems Engineering by the Virginia Tech Board of Visitors.

  7. Testes multinomiais otimizados: uma aplicação no equilíbrio genético de Hardy-Weinberg.

    OpenAIRE

    André Jalles Monteiro

    2002-01-01

    A estatística X2, quando na aplicação do teste de equilibrio genético de Hardy-weinberg, apresenta baixa eficiência, principalmente quando a amostra é de pequeno porte. Alguns procedimentos alternativos foram apresentados, com excelentes propriedades estatístcas: nivel de significância homogênio e não-viés. Esses procedimentos apresentam uma grande desvantagem prática: muitos pontos na região de rejeição são aleatorizados. No presente trabalho é apresentada uma nova propriedade, o máximo volu...

  8. Arnaut Daniel, “D’autra guiza e d’autra razo” (BdT 29.7

    Directory of Open Access Journals (Sweden)

    Gianluca Valenti

    2012-09-01

    Full Text Available This paper will focus on some specific aspects of Arnaut Daniel’s “D’autra guiza e d’autra razo” which, despite its success in its day and age (some verses were reused by Petrarch in the opening sonnet of the “RVF”, has received little critical attention in modern times. In particular, I will examine the incipit (whose alterity with respect to the rest of the Occitan lyric tradition points to an explicit declaration of intent on the part of the author, the lack of a tornada and, finally, the possibility that Arnaut Daniel was influenced by the section in the “Rhetorica ad Herennium” devoted to mnemonic technique. Moreover, the hypothesis that material concerning the art of memory has been used here helps to explain some particularly problematic textual loci, such as ll. 5-7 and 34.

  9. Warm Homes, Greener Living: Reducing Energy Poverty in Daniel McIntyre and St. Matthews through Energy Retrofits

    Science.gov (United States)

    Schulz, Kari

    This research examines energy poverty in the Daniel McIntyre and St. Matthews (DMSM) neighbourhoods in the city of Winnipeg. Energy poverty, defined as households spending more than 6% of their income on energy expenditures, affects as many as 50% of households in DMSM. Energy poverty can be alleviated through energy retrofits for dwellings such as weather stripping; increasing insulation in exterior walls, the attic and basement; and installing a high-efficiency furnace. The recommendations include: establishing consistent housing and energy efficiency policies; increasing the flexibility of utility on-bill financing; levying the necessary capital for energy retrofits through municipal financing mechanisms; increasing the knowledge and capacity of local residents; increasing the knowledge and capacity of local contractors for sustainable design and construction; creating a provincial strategy to increase the energy efficiency of social housing; developing low-income energy efficiency programs for rental properties; and increasing access to renewable energy sources.

  10. DANIEL MERRO JOHNSTON: EL AUTOR Y EL INTÉRPRETE. LE CORBUSIER Y AMANCIO WILLIAMS EN LA CASA CURUTCHET

    Directory of Open Access Journals (Sweden)

    Jorge Torres Cueco

    2011-11-01

    Full Text Available RESUMEN El origen de esta publicación es la tesis doctoral dirigida por los profesores José Morales y Carmen Espegel y defendida en la Escuela de Arquitectura de Madrid en mayo de 2009. Su título, El autor y el intérprete, nos da pistas sobre un nuevo y sugerente argumento bien distinto del libro precedente: la relación entre el autor del proyecto, Le Corbusier, y su intérprete, Amancio Williams, así como la compleja personalidad del Dr. Curutchet y su intervención durante todo este proceso.Con estos personajes Daniel Merro reconstruye el problema hermenéutico de la relación entre autor e intérprete, en una traslación a la arquitectura del trabajo que Paul Ricoeur realiza en Tiempo y Narración y La Metáfora viva en relación con La Poética de Aristóteles. Un sólido conocimiento y una hábil transcripción de sus ideas filosóficas han permitido realizar esta empresa con suficientes garantías y solvencia sobrada. Así, Daniel ha sabido recomponer las vicisitudes que mediaron entre la gestación del proyecto, la presencia del cliente y la recepción por parte del intérprete, Amancio Williams, y las alteraciones que, además, se produjeron con la entrada en escena de un postrero personaje, Simón Ungar, que dirigió las obras desde octubre de 1951.

  11. Juan Daniel Weber en Aullagas (1790: De minero de segunda en Europa a experto en Potosí

    Directory of Open Access Journals (Sweden)

    María Concepción Gavira Marquez

    2015-02-01

    Full Text Available Este trabajo aborda la expedición de metalúrgicos centro europeos comisionados por la Corona española para modernizar la minería americana a fines del siglo XVIII. En concreto, nos centraremos en un personaje especial, Juan Daniel Weber, miembro de la comisión destinada a la región andina liderada por Nordenflycht y que pasó por Potosí sin ningún éxito en cuanto a sus objetivos prioritarios. Aunque Weber en principio no estaba destinado a Alto Perú, permaneció en Potosí, donde se distinguió por dedicarse a defender sus intereses particulares en Aullagas, Chayanta, concretamente invirtiendo en empresas para el desagüe de la veta de Colquechaca y San Bartolomé.   This paper addresses the issue of Central European metal workers commissioned by the Spanish Crown to modernize the American mining activity in the late 18th century. In particular, we focus on a special character, Juan Daniel Weber, a member of the commission sent to the Andean region led by Nordenflycht and that passed by Potosí without achieving any of its main goals. Although, initially, Weber was not destined to go to Upper Peru, he stayed in Potosí, where he stood out for defending his own interests in Aullagas, Chayanta, investing specifically in companies dedicated to seam drainage in Colquechaca and San Bartolomé.

  12. The Effects of Professors' Race and Gender on Student Evaluations and Performance

    Science.gov (United States)

    Basow, Susan A.; Codos, Stephanie; Martin, Julie L.

    2013-01-01

    This experimental study examined the effects of professor gender, professor race, and student gender on student ratings of teaching effectiveness and amount learned. After watching a three-minute engineering lecture presented by a computer-animated professor who varied by gender and race (African American, White), female and male undergraduates…

  13. The Association of Professors' Style, Trait Anxiety, and Experience with Students' Grades.

    Science.gov (United States)

    Theodory, George C.; Day, Richard C.

    1985-01-01

    The relationship between the style, trait anxiety, and experience of professors and students' grades was investigated using Fiedler's contingency theory. Results indicated professors' trait anxiety is significant influencing student grades; professors having a high Least Preferred co-worker score assigned grades negatively correlated related with…

  14. Professors and Coaches Educational Approaches That Support the NCAA Division III Student Athlete Experience

    Science.gov (United States)

    Kuntz, Daniel E.

    2011-01-01

    While professors and coaches have the ability to enable or impede student athletes' educational success in college, studies that address the perspectives of coaches and professors about their interactions with student athletes are limited. This study aimed to understand (a) the ways in which professors and coaches who act as institutional agents…

  15. A Mixed Analysis of College Students' Best and Poorest College Professors

    Science.gov (United States)

    Slate, John R.; LaPrairie, Kimberly; Schulte, Don P.; Onwuegbuzie, Anthony J.

    2009-01-01

    In this study, the authors examined the views of 171 college students concerning their best and poorest college professors. In a multi-stage conversion mixed analysis design, students' stories of their best and poorest college professors were thematically analysed, resulting in 15 dominant themes for their best college professors and 12 dominant…

  16. A Changing Role for University Professors? Professorial Academic Leadership as It Is Perceived by "The Led"

    Science.gov (United States)

    Evans, Linda

    2015-01-01

    This article examines the academic leadership role of university professors in the UK (a grade title which in that national context generally refers only to the most distinguished, senior academics, who equate to the North American full professor). Drawing on theoretical interpretations of professionalism and applying these to professors, it…

  17. PREFACE: Special section on Computational Fluid Dynamics—in memory of Professor Kunio Kuwahara Special section on Computational Fluid Dynamics—in memory of Professor Kunio Kuwahara

    Science.gov (United States)

    Ishii, Katsuya

    2011-08-01

    This issue includes a special section on computational fluid dynamics (CFD) in memory of the late Professor Kunio Kuwahara, who passed away on 15 September 2008, at the age of 66. In this special section, five articles are included that are based on the lectures and discussions at `The 7th International Nobeyama Workshop on CFD: To the Memory of Professor Kuwahara' held in Tokyo on 23 and 24 September 2009. Professor Kuwahara started his research in fluid dynamics under Professor Imai at the University of Tokyo. His first paper was published in 1969 with the title 'Steady Viscous Flow within Circular Boundary', with Professor Imai. In this paper, he combined theoretical and numerical methods in fluid dynamics. Since that time, he made significant and seminal contributions to computational fluid dynamics. He undertook pioneering numerical studies on the vortex method in 1970s. From then to the early nineties, he developed numerical analyses on a variety of three-dimensional unsteady phenomena of incompressible and compressible fluid flows and/or complex fluid flows using his own supercomputers with academic and industrial co-workers and members of his private research institute, ICFD in Tokyo. In addition, a number of senior and young researchers of fluid mechanics around the world were invited to ICFD and the Nobeyama workshops, which were held near his villa, and they intensively discussed new frontier problems of fluid physics and fluid engineering at Professor Kuwahara's kind hospitality. At the memorial Nobeyama workshop held in 2009, 24 overseas speakers presented their papers, including the talks of Dr J P Boris (Naval Research Laboratory), Dr E S Oran (Naval Research Laboratory), Professor Z J Wang (Iowa State University), Dr M Meinke (RWTH Aachen), Professor K Ghia (University of Cincinnati), Professor U Ghia (University of Cincinnati), Professor F Hussain (University of Houston), Professor M Farge (École Normale Superieure), Professor J Y Yong (National

  18. A Critical Discussion of the Efficacy of Using Visual Learning Aids from the Internet to Promote Understanding, Illustrated with Examples Explaining the Daniell Voltaic Cell

    Science.gov (United States)

    Eilks, Ingo; Witteck, Torsten; Pietzner, Verena

    2009-01-01

    This paper discusses what chemistry students might see while working with animations found on the Internet and how these electronic illustrations can potentially interact to reinforce rather than resolve misconceptions about chemical principles that a student may possess. The Daniell voltaic cell serves as an example to illustrate the ways in…

  19. Professor Peter Higgs: "My Life as a Boson"

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    Professor Peter Higgs played a key role in the development of the Standard Model, our current theory of fundamental physics. The search for the Higgs Boson is the centrepiece of the LHC programme at CERN, and the existence of this famously elusive particle is likely to be confirmed or refuted with data currently being collected, using apparatus partly designed at Bristol. Professor Higgs will introduce the ideas of spontaneous symmetry breaking, and discuss how these developed from their application in condensed matter through the earlier work of Yoichiro Nambu and Jeffrey Goldstone, to the work of Robert Brout, Francois Englert and himself in 1964. The subsequent application of these ideas to electroweak theory will be discussed briefly.

  20. An Outstanding Career: Professor Emeritus Iacob Cătoiu

    Directory of Open Access Journals (Sweden)

    Octavian Oprică

    2016-05-01

    Full Text Available Through the duration of his commissions of Deputy Dean (1981-1989 and, respectively, Dean (1992-2003, and also by the manner of approaching the managerial problems and his scientific extension, Professor Iacob Cătoiu left and indelible trace on the evolution of the former Department of Commerce in the Bucharest University of Economic Studies (ASE – now the Department of Business and Tourism. He is author or co-author of an important number of books (57 and articles (105 and book presentations. Thus, after he made the personal acquaintance with Philip Kotler, the guru of international marketing, in 1997, Professor Iacob Cătoiu wrote the Forward to the Romanian version of Philip Kotler's volume Managementul marketingului (Marketing Management a fundamental book in its field. (Nicolae Lupu

  1. PHYSICAL ACTIVITY AND EATING HABITS IN UNIVERSITY PROFESSORS: LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Hector Luiz Rodrigues Munaro

    2015-01-01

    Full Text Available Increasingly, university professors engage in academic tasks often stressful and sedentary behaviors, making the practice of physical activity and healthier eating habits. The aim of this study was to review the literature Brazilian studies on physical activity and eating habits of university professors .The search was conducted between March and May 2013, in electronic databases. For the delimitation of the study, was used as descriptors: Physical Activity, University Teachers and Eating Habits. At the end of the article selection process, remaining 06 studies that have been described and discussed in the text. And all of a descriptive nature, with small samples with some robust and consistent methodology. The selected studies, regardless of their qualities, point to the need of this population to engage in more physical activity and healthy eating habits programs

  2. The University Professor View from the Communitarian Perspective

    Directory of Open Access Journals (Sweden)

    Angela Del Valle López

    2014-04-01

    Full Text Available The task of the university professor is a mission and not simply a profession and that is why higher education should be impregnated with values. Nowadays education is articulated into three areas: the State, the Market and the Volunteering, but no one of these three sectors by themselves has covered the needs of all the citizens, there have always been losers, therefore the conjunction of the three sectors became necessary. Communitarianism promotes an ethical-social pact that favors the progress of society without nullifying the individual dimension. It believes that the university is the space where a communitarian consciousness should be promoted to generate a social capital by means of education and it is a privilege place to substantiate the moral identity of the person beginning with the commitment of the professor with the university student.

  3. PHYSICAL ACTIVITY AND EATING HABITS IN UNIVERSITY PROFESSORS: LITERATURE REVIEW

    Directory of Open Access Journals (Sweden)

    Hector Luiz Rodrigues Munaro

    2015-03-01

    Full Text Available Increasingly, university professors engage in academic tasks often stressful and sedentary behaviors, making the practice of physical activity and healthier eating habits. The aim of this study was to review the literature Brazilian studies on physical activity and eating habits of university professors .The search was conducted between March and May 2013, in electronic databases. For the delimitation of the study, was used as descriptors: Physical Activity, University Teachers and Eating Habits. At the end of the article selection process, remaining 06 studies that have been described and discussed in the text. And all of a descriptive nature, with small samples with some robust and consistent methodology. The selected studies, regardless of their qualities, point to the need of this population to engage in more physical activity and healthy eating habits programs.

  4. [The professor-student relationship in coping with dying].

    Science.gov (United States)

    Pinho, Líũcia Maria Oliveira; Barbosa, Maria Alves

    2010-03-01

    The new guidelines for undergraduate courses in the field of health care imply a need to prepare professionals to deal with life and death. To study death and dying in the context of nurse education means to contribute to the humanization of education and to preparing humanistic and critical professionals. We performed individual interviews with professors so that each could reveal their thoughts about experiencing death and dying in the educational relationship between nurse/professor and the nursing student in the hospital environment. Content analysis was performed using ideas close to those of Heidegger, revealing that education towards the concept and experience of death appears to be possible only if there is reflection regarding human existence, thoughts, and accepting finitude. By understanding one's own attitudes towards death and existence, it is possible to perceive possibilities in education for care in the death process.

  5. The university professor: integration between the personal and professional dimension

    Directory of Open Access Journals (Sweden)

    José Javier BERMÚDEZ-APONTE

    2017-12-01

    Full Text Available In the first part of this article, the authors explain how the teaching role is affected by certain social and cultural changes, like the knowledge society emergence, the universities orientation towards marketing, the constant demand and pressure exerted on teachers to publish, the loss of the ethical sense in the academic activity and the disparity of tasks that are being assigned to the university professors. In view of the above, a comprehensive model, compound by two concepts –personal and professional– of a university professor is proposed; in fact, this model incorporates and summarises different contributions regarding this theme. Finally, this article aims to defend the need to understand the teaching role as a vocation, in the broadest sense of the word, a vocation carries the inclination to pursue an aim: the education of those students that teachers have in charge.

  6. [Analysis of professor WU Lianzhong's experience of neck acupoints application].

    Science.gov (United States)

    Peng, Jiandong; Zheng, Hongyan; Wang, Yingshu

    2015-09-01

    Professor WU Lianzhong's experience of neck acupoints application is introduced. The characteristics,locations, acupuncture manipulations ,efficiency and main functions of neck acupoints including Tiandixue (Extra), Jingbixue (Extra), and cervical Jiaji (EX-B 2) are stated. According to the TCM thought of treatment based on syndrome differentiation,WU Lianzhong's special theory of neck acupoints application is explained so as to provide experience for improving acupuncture effects.

  7. YouTube Professors Scholars as Online Video Stars

    Science.gov (United States)

    Young, Jeffrey R.

    2008-01-01

    This article takes a look at how professors are becoming the latest YouTube stars. The popularity of their appearances on YouTube and other video-sharing sites end up opening the classroom and making teaching--which once took place behind closed doors--a more public art. Web videos open a new form of public intellectualism to scholars looking to…

  8. YouTube Professors: Scholars as Online Video Stars

    Science.gov (United States)

    Young, Jeffrey R.

    2008-01-01

    This article takes a look at the rising popularity of professors as the latest YouTube stars. The popularity of their appearances on YouTube and other video-sharing sites is making it possible for classrooms to be opened up and making teaching--which once took place behind closed doors--a more public art. Web video has generated a new form of…

  9. Professor V. Weisskopf, CERN Director General (1961-1965)

    CERN Multimedia

    1962-01-01

    Well known theoretical physicist Victor Weisskopf has died aged 93. Born in Austria, he later worked with Schrodinger in Berlin before emigrating to the US in 1937, where he joined the Manhattan project in 1944, and was witness to the Trinity Test in July 1945. In 1946 he became professor of physics at MIT. He took leave of absence to be Director General of CERN, the European Organization for Nuclear Physics, from 1961-1965.

  10. Professor Created On-line Biology Laboratory Course

    Science.gov (United States)

    Bowman, Arthur W.

    2010-01-01

    This paper will share the creation, implementation, and modification of an online college level general biology laboratory course offered for non-science majors as a part of a General Education Curriculum. The ability of professors to develop quality online laboratories will address a growing need in Higher Education as more institutions combine course sections and look for suitable alternative course delivery formats due to declining departmental budgets requiring reductions in staffing, equipment, and supplies. Also, there is an equal or greater need for more professors to develop the ability to create online laboratory experiences because many of the currently available online laboratory course packages from publishers do not always adequately parallel on-campus laboratory courses, or are not as aligned with the companion lecture sections. From a variety of scientific simulation and animation web sites, professors can easily identify material that closely fit the specific needs of their courses, instructional environment, and students that they serve. All too often, on-campus laboratory courses in the sciences provide what are termed confirmation experiences that do NOT allow students to experience science as would be carried out by scientists. Creatively developed online laboratory experiences can often provide the type of authentic investigative experiences that are not possible on-campus due to the time constraints of a typical two-hour, once-per-week-meeting laboratory course. In addition, online laboratory courses can address issues related to the need for students to more easily complete missing laboratory assignments, and to have opportunities to extend introductory exercises into more advanced undertakings where a greater sense of scientific discovery can be experienced. Professors are strongly encourages to begin creating online laboratory exercises for their courses, and to consider issues regarding assessment, copyrights, and Intellectual Property

  11. Professors, principals and textbooks from the Midwifery school in Zadar.

    Science.gov (United States)

    Maksimović, Jovan; Maksimović, Marko

    2017-06-01

    Midwifery in Dalmatia was highly undeveloped at the beginning of the XIX century. The health report from 1813 suggested that there were only 48 midwives in the whole province, and none of them with a degree from the midwifery school. After abolishing the Central Schools ("Ecoles Centrales"), which were founded at the time of French reign, and which had the university range, the professors who stayed in Zadar continued their work and teaching in the Midwifery School, which was founded in 1820 according to the decision made by Emperor Franz I, and started working in 1821. Since the school was working continuously for the whole century, a lot of professors and principals passed through. Protomedicus of Dalmatia officially performed the duty of principals of the Midwifery School. Their life and work biographies were gathered in this paper. Although the newcomers were mostly illiterate, very contemporary and valuable textbooks were used at that time. The professors of this school wrote some of these textbooks. This paper analyses those textbooks from the current medical science and praxis point of view, which points out to its significance and contribution of its authors to the reputation that the School enjoyed at that time.

  12. Comunidades em processos formativos de professores de ciências

    Directory of Open Access Journals (Sweden)

    Willian Rubira da Silva

    2017-12-01

    Full Text Available Apresentamos compreensões sobre as diferentes concepções de comunidade dentro do contexto da formação de professores de Ciências. Termos relacionados a comunidades no contexto de ensino e aprendizagem vem se tornando genéricos, dificultando compreensões de trabalhos da área no Brasil. Visualizamos a necessidade de significar concepções do termo em questão no contexto da sociologia e psicologia para então avançar nas compreensões mais abrangentes dentro da educação. Ampliamos o estudo com uma revisão dos trabalhos publicados nos anais do Encontro Nacional de Pesquisa em Educação em Ciências correlacionando a formação de professores com as perspectivas teórico-práticas de comunidades em contexto educacional. Escolhemos os anais deste evento por ser um ponto de debate entre os pesquisadores na área de Educação em Ciências e que, desta maneira, nos possibilitou sistematizar diferentes concepções de comunidades. Essas foram agrupadas em 7 categorias emergentes distintas por aspectos teórico-práticos utilizados nos processos formativos de professores de Ciências.

  13. Volume celebrating the 60th birthday of Professor Dr. Franz Fie; Professor Dr. Franz Fiedler zum 60. Geburtstag

    Energy Technology Data Exchange (ETDEWEB)

    Beheng, K.D. [ed.

    1998-01-01

    This report was compiled in honor of Professor Dr. Franz Fiedler on the occasion of his 60th birthday on 7 January 1998. Its contributions deal with mesoscale modelling, the propagation of air pollutants, measurements of precipitation using radar, and prediction models. (orig./KW) [Deutsch] Dieser Bericht wurde aus Anlass des 60. Geburtstags von Herrn Prof. Dr. Franz Fiedler am 7. Januar 1998 zusammengestellt. Die Beitraege behandeln mesoskalige Modellierung, Ausbreitung von Luftschadstoffen, Niederschlagsmessung mit Radar und Vorhersagemodelle. (orig.)

  14. Graduate Student Attitudes toward Professor Pedagogical Content Knowledge, Transformational Teaching Practices, Student-Professor Engagement in Learning, and Student Deep Learning in Worldwide Business and Education Programs

    Science.gov (United States)

    Economos, Jennifer Lynn

    2013-01-01

    Some professors are expected to remain competitive research scholars, as well as teach, particularly in research-intensive universities. It has been argued that some professors spend too much time on research to obtain institutional incentives or promotion, and not enough time on teaching. Consequently, some adjuncts assume the responsibility for…

  15. EDITORIAL: 65th Birthday of Professor Hauptmann 65th Birthday of Professor Hauptmann

    Science.gov (United States)

    Lucklum, Ralf

    2009-12-01

    The papers in this special feature have been contributed by scientific partners in international research projects and from former PhD students of the Editor-in-Chief of this journal, Professor Dr Peter Hauptmann. The motivation for this feature is the occasion of Peter Hauptmann's 65th birthday on 24 July 2009 and his retirement from his chair at the Otto-von-Guericke-University, Magdeburg, Germany this autumn. Peter graduated in Physics at the Technical University Dresden and received his PhD from the Technical University Leuna-Merseburg in 1973. He habilitated in 1979. With his appointment at the Faculty of Electrical Engineering and Information Technology in 1985 the Chair of Measurement Science extended its profile to the fast growing area of sensors. Peter was one of the very early developers of ultrasonic sensor systems for process monitoring and quality assurance. The working style here was characteristic of all his future activities. He combined his background in theory and experiment on ultrasonic wave propagation and its application to material science with the advantages of rapidly developing capabilities in microelectronics and data processing. The results have meanwhile found their way into products that are now on the market worldwide. Germany's reunification opened the door to the international sensor community and the most challenging sensor research areas. Peter Hauptmann very soon became a well respected colleague and was consequently appointed as member of the Technical Program Committee of the most important sensor conferences, elected member and head of expert groups of research associations and funding organizations, and of course reviewer of many scientific journals. Nowadays Peter Hauptmann can rightly be called one of the key players in the area of sensors. Professor Hauptmann's research interests combine fundamental aspects of the sensor transduction scheme with application issues up to the use of the sensor system in the industrial world

  16. On being a discontinuous person: Ontological insecurity, the wounded storyteller and time in Daniel Keyes’s Flowers for Algernon

    Directory of Open Access Journals (Sweden)

    Tony Ullyatt

    2015-03-01

    Full Text Available This article explores ontological security and insecurity in Daniel Keyes’s novel, Flowers for Algernon. It opens with a very brief overview of the 1960s counter-culture to contextualise not only Keyes’s novel but also Laing’s theories of ontological (insecurity. After a discussion of Laing’s concept of ontological security and insecurity, the focus shifts to Arthur W. Frank’s notions of the wounded storyteller and how Charlie Gordon’s entry into the medical world constitutes a colonisation of the body that brings with it a deepening sense of ontological insecurity. In entering the world of medical research, Charlie becomes the wounded storyteller, offering a first-person account of his experiences during the experiment and its aftermath. As the initial success of the surgery deteriorates steadily into failure, with the protagonist’s intelligence returning steadily to its pre-operation level, the question of time and how he can make the best use of it to record the experiment becomes paramount. The final section of the article centres on the growing link between the surgery’s failure and how it increases the protagonist’s ontological insecurity. He uses the diminishing amount of time available to him in search of understanding the fuller implications of the experiment. Eventually, he reverts to his initial rudimentary ontological security when he finds himself with the same intellectual level, as prior to the experiment.

  17. Using frequency response functions to manage image degradation from equipment vibration in the Daniel K. Inouye Solar Telescope

    Science.gov (United States)

    McBride, William R.; McBride, Daniel R.

    2016-08-01

    The Daniel K Inouye Solar Telescope (DKIST) will be the largest solar telescope in the world, providing a significant increase in the resolution of solar data available to the scientific community. Vibration mitigation is critical in long focal-length telescopes such as the Inouye Solar Telescope, especially when adaptive optics are employed to correct for atmospheric seeing. For this reason, a vibration error budget has been implemented. Initially, the FRFs for the various mounting points of ancillary equipment were estimated using the finite element analysis (FEA) of the telescope structures. FEA analysis is well documented and understood; the focus of this paper is on the methods involved in estimating a set of experimental (measured) transfer functions of the as-built telescope structure for the purpose of vibration management. Techniques to measure low-frequency single-input-single-output (SISO) frequency response functions (FRF) between vibration source locations and image motion on the focal plane are described. The measurement equipment includes an instrumented inertial-mass shaker capable of operation down to 4 Hz along with seismic accelerometers. The measurement of vibration at frequencies below 10 Hz with good signal-to-noise ratio (SNR) requires several noise reduction techniques including high-performance windows, noise-averaging, tracking filters, and spectral estimation. These signal-processing techniques are described in detail.

  18. Public Lecture | The long road to the LHC | Prof. Lyn Evans, Dr. Daniel Treille and Prof. Peter Jenni | 9 October

    CERN Multimedia

    2014-01-01

    “The long road to the LHC” by Prof. Lyn Evans, Dr. Daniel Treille and Prof. Peter Jenni. Thursday 9 October, 7.30 p.m. in the Globe of Science and Innovation. Talk in English with simultaneous interpreting into French.  Entrance free. Limited number of seats. Reservation essential: +41 22 767 76 76 or cern.reception@cern.ch   Lyn Evans. Lecture by Lyn Evans Abstract The key to the discovery of the Higgs boson has been the development of particle accelerators at CERN over the years. I will explain how a particle accelerator works and will follow the path from the construction of the Proton Synchrotron in the 1950s to the world’s most powerful colliding beam machine, the Large Hadron Collider. Biography Born in 1945, Lyn Evans has spent his whole career in the field of high energy physics and particle accelerators, participating in all the great projects of CERN. From 1993 he led the team that designed, built and commissioned the LHC. He is currently ...

  19. La muerte de Daniel Alcides Carrión: una revisión crítica

    Directory of Open Access Journals (Sweden)

    David Salinas-Flores

    2009-06-01

    Full Text Available El experimento de Daniel Alcides Carrión marcó un hito en la historia de la medicina peruana. Alrededor de él ha existido mucha controversia. Quizás, el principal tema de debate sea la causa de su muerte. En la controversia, ha pasado desapercibido un hecho objetivo ocurrido en las últimas horas del experimento: la administración de inyecciones endovenosas de ácido fénico. Esta fue una terapia propuesta en Perú en aquella época como tratamiento del carbunco. Los médicos de la junta médica, en la agonía de Carrión, probablemente no administraron la transfusión sanguínea a Carrión, para experimentar con este tratamiento. La junta médica pensaba quizás repetir con la bartonelosis el éxito descrito que tuvieron las inyecciones de ácido fénico con el carbunco. Desconocían la actualmente demostrada toxicidad de esta sustancia. Probablemente, el evento precipitante de la muerte de Carrión fue una intoxicación por ácido fénico en un paciente con bartonelosis en fase anémica.

  20. Effect of a 21 day Daniel Fast on metabolic and cardiovascular disease risk factors in men and women

    Directory of Open Access Journals (Sweden)

    Bloomer Richard J

    2010-09-01

    Full Text Available Abstract Background Dietary modification via caloric restriction is associated with multiple effects related to improved metabolic and cardiovascular health. However, a mandated reduction in kilocalories is not well-tolerated by many individuals, limiting the long-term application of such a plan. The Daniel Fast is a widely utilized fast based on the Biblical book of Daniel. It involves a 21 day ad libitum food intake period, devoid of animal products and preservatives, and inclusive of fruits, vegetables, whole grains, legumes, nuts, and seeds. The purpose of the present study was to determine the efficacy of the Daniel Fast to improve markers of metabolic and cardiovascular disease risk. Methods 43 subjects (13 men; 30 women; 35 ± 1 yrs; range: 20-62 yrs completed a 21 day period of modified food intake in accordance with detailed guidelines provided by investigators. All subjects purchased and prepared their own food. Following initial screening, subjects were given one week to prepare for the fast, after which time they reported to the lab for their pre-intervention assessment (day 1. After the 21 day fast, subjects reported to the lab for their post-intervention assessment (day 22. For both visits, subjects reported in a 12 hr fasted state, performing no strenuous physical activity during the preceding 24-48 hrs. At each visit, mental and physical health (SF-12 form, resting heart rate and blood pressure, and anthropometric variables were measured. Blood was collected for determination of complete blood count, metabolic panel, lipid panel, insulin, HOMA-IR, and C-reactive protein (CRP. Subjects' self-reported compliance, mood, and satiety in relation to the fast were also recorded. Diet records were maintained by all subjects during the 7 day period immediately prior to the fast (usual intake and during the final 7 days of the fast. Results Subjects' compliance to the fast was 98.7 ± 0.2% (mean ± SEM. Using a 10 point scale, subjects

  1. Fatores associados a patologias de pregas vocais em professores

    Directory of Open Access Journals (Sweden)

    Carla Lima de Souza

    2011-10-01

    Full Text Available OBJETIVO: Analisar fatores associados à prevalência do diagnóstico médico referido de patologias das pregas vocais em professores. MÉTODOS: Estudo epidemiológico transversal, censitário, com 4.495 professores da rede pública municipal de ensino elementar e fundamental de Salvador, BA, de março a abril de 2006. A variável dependente foi o diagnóstico médico referido de patologias das pregas vocais e as independentes, características sociodemográficas, atividade profissional, organização do trabalho/relações interpessoais, características físicas do ambiente de trabalho, freqüência de transtornos mentais comuns, medida pelo Self-Reporting Questionnaire-20 (SRQ-20 >7 e condições de saúde geral. Foram aplicadas técnicas de análise estatística descritiva, bivariada e regressão logística múltipla. RESULTADOS: A prevalência de diagnóstico médico referido de patologias das pregas vocais foi de 18,9%. Na análise de regressão logística, as variáveis que permaneceram associadas ao diagnóstico médico de patologia das pregas vocais foram: sexo feminino, trabalhar como professor por mais de sete anos, uso intensivo da voz, referir mais de cinco características desfavoráveis do ambiente físico de trabalho, uma ou mais doenças do trato respiratório, perda auditiva e apresentar transtornos mentais comuns. CONCLUSÕES: A presença de patologias das pregas vocais referidas associou-se a fatores que indicam a necessidade de ações de promoção da saúde vocal do professor e modificações na organização e estrutura do trabalho docente.

  2. Professor Borje Kullenberg (1906-1991): Biography and bibliography

    Digital Repository Service at National Institute of Oceanography (India)

    Sengupta, R.; Eriksson, G.

    was undisturbed, the “vacuum principle” was omitted and the “piston principle” and “free-fall principle”, were combined, utilising the enormous hydrostatic pressures at great ocean depths. Thus the piston corer, capable of collecting sediment cores up to 20 m... in the artillery he had to criss-cross Sweden many times on skis on important missions. No wonder he had a strong physique throughout his life! After the cessation of hostilities, all the flaws of the piston corer were rectified and a cruise 2 Professor Biirje...

  3. PROFESSOR DR. ION PIŞOTA (1925 – 2008)

    OpenAIRE

    Liliana ZAHARIA

    2009-01-01

    Professor Ion Pişota was born on June 6, 1925, in Hrupiştea, a small settlement in Greek Macedonia, from where he and his family came to Romania in 1927, where he got Romanian citizenship. Between 1941 and 1945, he attended the Tulcea Boys High School and later on, in 1947 he entered the Faculty of Geology – Geography at the University of Bucharest, where he continued to excel until 1951, when he graduated. In the fall of 1950, he took up a tutor position in the field of Hydrolgy at the same ...

  4. The Forgetful Professor and the Space Biology Adventure

    Science.gov (United States)

    Massa, Gioia D.; Jones, Wanda; Munoz, Angela; Santora, Joshua

    2014-01-01

    This video was created as one of the products of the 2013 ISS Faculty Fellows Summer Program. Our High School science teacher faculty fellows developed this video as an elementary/middle school education component. The video shows a forgetful professor who is trying to remember something, and along the journey she learns more about the space station, space station related plant science, and the Kennedy Space Center. She learns about the Veggie hardware, LED lighting for plant growth, the rotating garden concept, and generally about space exploration and the space station. Lastly she learns about the space shuttle Atlantis.

  5. [Preliminary study on Professor SUN Liu-he's academic thought].

    Science.gov (United States)

    Sun, Guo-Sheng; Zhang, Jing-Feng

    2005-07-01

    Professor SUN Liu-he has been engaged in scientific research, clinical and teaching works for tens years and he is a meticulous scholar with great learning, rich clinical experience and great theoretical attainments. In clinical practice of many years, he summarizes and develops Kangai Plaster, Kangai Fushui Plaster, Ai tong Ling Plaster, and so on for acupoint sticking to treat tumors, and establishes Nu-needle hot-reinforcing method and Ti-Yun reducing method, enriching contents of needling methods, and he is good at application of specific points, established points and channel acupoints to treat refractory diseases with good results.

  6. Comunidades em processos formativos de professores de ciências

    OpenAIRE

    Willian Rubira da Silva; Valmir Heckler

    2017-01-01

    Apresentamos compreensões sobre as diferentes concepções de comunidade dentro do contexto da formação de professores de Ciências. Termos relacionados a comunidades no contexto de ensino e aprendizagem vem se tornando genéricos, dificultando compreensões de trabalhos da área no Brasil. Visualizamos a necessidade de significar concepções do termo em questão no contexto da sociologia e psicologia para então avançar nas compreensões mais abrangentes dentro da educação. Ampliamos o estudo com uma ...

  7. A biographical note on Marcel Proust's Professor Cottard.

    Science.gov (United States)

    Pearn, John; Gardner-Thorpe, Christopher

    2003-05-01

    A medical practitioner, Professor Cottard, features in Marcel Proust's A la recherche du temps perdu, which has been described as one of the supreme achievements of world literature. Proust modelled the character of Cottard on the real-life Parisian neurologist and psychiatrist Dr Jules Cotard (1840-1889). Marcel Proust's father, Dr Adrien Proust, was an eminent Parisian surgeon and a contemporary of Cotard. A review of the biographical literature (in French) relating to Dr Jules Cotard and an analysis of his published work (in English and French) have revealed a striking parallelism between the lives of the fictional Cottard and Jules Cotard.

  8. Bas van Fraassen y la Ley de Hardy-Weinberg: Una Discussión y Desarrollo de su Diagnóstico

    Directory of Open Access Journals (Sweden)

    Pablo Lorenzano

    2008-12-01

    Full Text Available The aim of this article is to discuss and develop the diagnose of the Hardy- Weinberg law made by van Fraassen (1987, p. 110, according to which: 1 that law cannot be considered a law used as an axiom for the classical population genetics as a whole, since it is an equilibrium-law that holds only under certain special conditions; 2 it just determines a subclass of models; 3 its generalization shades off into logical vacuity; and 4 more complex variants of the law can be deduced for more realistic assumptions. The discussion and development of such a diagnose will be carried out with the notions of another semantic conceptions of theories, related to that of van Fraassen, namely, the structuralist view of theories, and a rational reconstruction of classical population genetics made within the framework of such a metatheory, also presented in this paper.

  9. Estimating risks and relative risks in case-base studies under the assumptions of gene-environment independence and Hardy-Weinberg equilibrium.

    Science.gov (United States)

    Chui, Tina Tsz-Ting; Lee, Wen-Chung

    2014-01-01

    Many diseases result from the interactions between genes and the environment. An efficient method has been proposed for a case-control study to estimate the genetic and environmental main effects and their interactions, which exploits the assumptions of gene-environment independence and Hardy-Weinberg equilibrium. To estimate the absolute and relative risks, one needs to resort to an alternative design: the case-base study. In this paper, the authors show how to analyze a case-base study under the above dual assumptions. This approach is based on a conditional logistic regression of case-counterfactual controls matched data. It can be easily fitted with readily available statistical packages. When the dual assumptions are met, the method is approximately unbiased and has adequate coverage probabilities for confidence intervals. It also results in smaller variances and shorter confidence intervals as compared with a previous method for a case-base study which imposes neither assumption.

  10. On S.N. Bernstein’s derivation of Mendel’s Law and ‘rediscovery’ of the Hardy-Weinberg distribution

    Science.gov (United States)

    Stark, Alan; Seneta, Eugene

    2012-01-01

    Around 1923 the soon-to-be famous Soviet mathematician and probabilist Sergei N. Bernstein started to construct an axiomatic foundation of a theory of heredity. He began from the premise of stationarity (constancy of type proportions) from the first generation of offspring. This led him to derive the Mendelian coefficients of heredity. It appears that he had no direct influence on the subsequent development of population genetics. A basic assumption of Bernstein was that parents coupled randomly to produce offspring. This paper shows that a simple model of non-random mating, which nevertheless embodies a feature of the Hardy-Weinberg Law, can produce Mendelian coefficients of heredity while maintaining the population distribution. How W. Johannsen’s monograph influenced Bernstein is discussed. PMID:22888285

  11. The London-Anderson-Englert-Brout-Higgs-Guralnik-Hagen-Kibble-Weinberg mechanism and Higgs boson reveal the unity and future excitement of physics

    Science.gov (United States)

    Allen, Roland E.

    2014-01-01

    The particle recently discovered by the CMS and ATLAS collaborations at CERN is almost certainly a Higgs boson, fulfilling a quest that can be traced back to three seminal high-energy papers of 1964, but which is intimately connected to ideas in other areas of physics that go back much further. One might oversimplify the history of the features which (i) give mass to the W and Z particles that mediate the weak nuclear interaction, (ii) effectively break gauge invariance, (iii) eliminate physically unacceptable Nambu-Goldstone bosons, and (iv) give mass to fermions (like the electron) by collectively calling them the London-Anderson-Englert-Brout-Higgs-Guralnik-Hagen-Kibble-Weinberg mechanism. More important are the implications for the future: a Higgs boson appears to point toward supersymmetry, since new physics is required to protect its mass from enormous quantum corrections, while the discovery of neutrino masses seems to point toward grand unification of the non-gravitational forces.

  12. Bas Van Fraassen y la Ley de Hardy-Weinberg: una discusión y desarrolo de su diagnóstico

    OpenAIRE

    Lorenzano, Pablo

    2008-01-01

    http://dx.doi.org/10.5007/1808-1711.2008v12n2p121O objetivo deste trabalho é discutir e desenvolver o diagnóstico que efetua van Fraassen (1987, p. 110) da lei de Hardy-Weinberg, de acordo coo qual esta: 1) não pode ser considerada uma lei a ser utilizada como un axioma da teoria genética de populações, pois é uma lei de equilíbrio que só vale sob certas condições especiais, 2) só determina uma subclasse de modelos, 3) sua generalização resulta vácua e 4) variantes complexas da lei podem ser ...

  13. Bosonic and fermionic Weinberg-Joos (j,0) + (0,j) states of arbitrary spins as Lorentz tensors or tensor-spinors and second-order theory

    Energy Technology Data Exchange (ETDEWEB)

    Delgado Acosta, E.G.; Banda Guzman, V.M.; Kirchbach, M. [UASLP, Instituto de Fisica, San Luis Potosi (Mexico)

    2015-03-01

    We propose a general method for the description of arbitrary single spin-j states transforming according to (j, 0) + (0, j) carrier spaces of the Lorentz algebra in terms of Lorentz tensors for bosons, and tensor-spinors for fermions, and by means of second-order Lagrangians. The method allows to avoid the cumbersome matrix calculus and higher ∂{sup 2j} order wave equations inherent to the Weinberg-Joos approach. We start with reducible Lorentz tensor (tensor-spinor) representation spaces hosting one sole (j, 0) + (0, j) irreducible sector and design there a representation reduction algorithm based on one of the Casimir invariants of the Lorentz algebra. This algorithm allows us to separate neatly the pure spin-j sector of interest from the rest, while preserving the separate Lorentz and Dirac indexes. However, the Lorentz invariants are momentum independent and do not provide wave equations. Genuine wave equations are obtained by conditioning the Lorentz tensors under consideration to satisfy the Klein-Gordon equation. In so doing, one always ends up with wave equations and associated Lagrangians that are of second order in the momenta. Specifically, a spin-3/2 particle transforming as (3/2, 0) + (0, 3/2) is comfortably described by a second-order Lagrangian in the basis of the totally anti-symmetric Lorentz tensor-spinor of second rank, Ψ {sub [μν]}. Moreover, the particle is shown to propagate causally within an electromagnetic background. In our study of (3/2, 0) + (0, 3/2) as part of Ψ {sub [μν]} we reproduce the electromagnetic multipole moments known from the Weinberg-Joos theory. We also find a Compton differential cross-section that satisfies unitarity in forward direction. The suggested tensor calculus presents itself very computer friendly with respect to the symbolic software FeynCalc. (orig.)

  14. Hardy-Weinberg equilibrium analysis of the 48 bp VNTR in the III exon of the DRD4 gene in a sample of parents of ADHD cases.

    Science.gov (United States)

    Trejo, Salvador; Toscano-Flores, José J; Matute, Esmeralda; Ramírez-Dueñas, María de Lourdes

    2015-01-01

    The aim of this study was to obtain the genotype and gene frequency from parents of children with attention-deficit/hyperactivity disorder (ADHD) and then assess the Hardy-Weinberg equilibrium of genotype frequency of the variable number tandem repeat (VNTR) III exon of the dopamine receptor D4 (DRD4) gene. The genotypes of the III exon of 48 bp VNTR repeats of the DRD4 gene were determined by polymerase chain reaction in a sample of 30 parents of ADHD cases. In the 60 chromosomes analyzed, the following frequencies of DRD4 gene polymorphisms were observed: six chromosomes (c) with two repeat alleles (r) (10%); 1c with 3r (1.5%); 36c with 4r (60%); 1c with 5r (1.5%); and 16c with 7r (27%). The genotypic distribution of the 30 parents was two parents (p) with 2r/2r (6.67%); 1p with 2r/4r (3.33%); 1p with 2r/5r (3.33%); 1p with 3r/4r (3.33%); 15p with 4r/4r (50%); 4p with 4r/7r (13.33); and 6p with 7r/7r (20%). A Hardy-Weinberg disequilibrium (χ (2)=13.03, P<0.01) was found due to an over-representation of the 7r/7r genotype. These results suggest that the 7r polymorphism of the DRD4 gene is associated with the ADHD condition in a Mexican population.

  15. Tests for establishing compatibility of an observed genotype distribution with Hardy-Weinberg equilibrium in the case of a biallelic locus.

    Science.gov (United States)

    Wellek, Stefan

    2004-09-01

    The classical chi(2)-procedure for the assessment of genetic equilibrium is tailored for establishing lack rather than goodness of fit of an observed genotype distribution to a model satisfying the Hardy-Weinberg law, and the same is true for the exact competitors to the large-sample procedure, which have been proposed in the biostatistical literature since the late 1930s. In this contribution, the methodology of statistical equivalence testing is adopted for the construction of tests for problems in which the assumption of approximate compatibility of the genotype distribution actually sampled with Hardy-Weinberg equilibrium (HWE) plays the role of the alternative hypothesis one aims to establish. The result of such a construction highly depends on the choice of a measure of distance to be used for defining an indifference zone containing those genotype distributions whose degree of disequilibrium shall be considered irrelevant. The first such measure proposed here is the Euclidean distance of the true parameter vector from that of a genotype distribution with identical allele frequencies being in strict HWE. The second measure is based on the (scalar) parameter of the distribution first introduced into the present context by Stevens (1938, Annals of Eugenics 8, 377-383). The first approach leads to a nonconditional test (which nevertheless can be carried out in a numerically exact way), the second to an exact conditional test shown to be uniformly most powerful unbiased (UMPU) for the associated pair of hypotheses. Both tests are compared in terms of the exact power attained against the class of those specific alternatives under which HWE is strictly satisfied.

  16. Bosonic and fermionic Weinberg-Joos (j,0) ⊕ (0,j) states of arbitrary spins as Lorentz tensors or tensor-spinors and second-order theory

    Science.gov (United States)

    Delgado Acosta, E. G.; Banda Guzmán, V. M.; Kirchbach, M.

    2015-03-01

    We propose a general method for the description of arbitrary single spin- j states transforming according to ( j, 0) ⊕ (0, j) carrier spaces of the Lorentz algebra in terms of Lorentz tensors for bosons, and tensor-spinors for fermions, and by means of second-order Lagrangians. The method allows to avoid the cumbersome matrix calculus and higher ∂2 j order wave equations inherent to the Weinberg-Joos approach. We start with reducible Lorentz tensor (tensor-spinor) representation spaces hosting one sole ( j, 0) ⊕ (0, j) irreducible sector and design there a representation reduction algorithm based on one of the Casimir invariants of the Lorentz algebra. This algorithm allows us to separate neatly the pure spin- j sector of interest from the rest, while preserving the separate Lorentz and Dirac indexes. However, the Lorentz invariants are momentum independent and do not provide wave equations. Genuine wave equations are obtained by conditioning the Lorentz tensors under consideration to satisfy the Klein-Gordon equation. In so doing, one always ends up with wave equations and associated Lagrangians that are of second order in the momenta. Specifically, a spin-3/2 particle transforming as (3/2, 0) ⊕ (0, 3/2) is comfortably described by a second-order Lagrangian in the basis of the totally anti-symmetric Lorentz tensor-spinor of second rank, Ψ [ μν]. Moreover, the particle is shown to propagate causally within an electromagnetic background. In our study of (3/2, 0) ⊕ (0, 3/2) as part of Ψ [ μν] we reproduce the electromagnetic multipole moments known from the Weinberg-Joos theory. We also find a Compton differential cross-section that satisfies unitarity in forward direction. The suggested tensor calculus presents itself very computer friendly with respect to the symbolic software FeynCalc.

  17. La fortuna del ciclo de "Daniel en el foso de los leones" en los programas escultóricos románicos de Galicia

    Directory of Open Access Journals (Sweden)

    Moure Pena, Teresa C.

    2006-09-01

    Full Text Available This study is focused on the iconographic cycle of Daniel in the Lions Den within the sculptural programs of the Galician Romanesque. Analysis of the representations allows for the proposal of a series of theories concerning the connection between figuration and context, and particularly the value and signification acquired by the theme in the monastic milieu.

    El objetivo de este artículo se centra en el estudio del ciclo iconográfico de Daniel en el foso de los leones en los programas figurativos del románico gallego. El análisis de las representaciones nos permitirá proponer una serie de teorías sobre la conexión entre figuración y el contexto en el que se dispone y, especialmente el valor y significado que el tema adquiere en el ámbito monástico.

  18. Transactional sex and sexual harassment between professors and students at an urban university in Benin.

    Science.gov (United States)

    Eller, Amanda

    2016-07-01

    This paper adds to discussion of transactional sex relationships in Africa by examining the distinction between transactional sex and sexual harassment in the context of professor-student relationships and their inherent power dynamics. By exploring the ways in which female university students in urban Benin toe the line between empowered agent and victim, I show how the power differential between professor and student obstructs the professor's ability to objectively determine consent, and examine why, in spite of this differential, male professors are frequently perceived as the victims of these relationships. Ethnographic data were gathered through participant observation on a public university campus in Benin and in-depth interviews and focus groups with 34 students and 5 professors from that university. Findings suggest that the problem of sexual harassment on campus will be difficult to address so long as transactional sex relationships between professors and students are permitted to continue.

  19. [Professor as a facilitating agent of the teaching learning process: perspective of the nursing student].

    Science.gov (United States)

    Semim, Gabriela Maschio; Souza, Maria Conceição Bernardo de Mello; Corrêa, Adriana Kátia

    2009-09-01

    This study aimed at analyzing how the undergraduate student perceives professor's performance in the teaching-learning process, in courses using the critical pedagogy and dialogical competence approach, in the Nursing Bachelor's Program, from 2005 to 2006. An instrument for the assessment of the professors performance was used and answers from 142 students were analyzed. Through thematic analysis, the following meaning units were outlined approaching the teaching-learning process, professor/student relationship and evaluation. For most students, professors who stimulate the critical-reflexive process, coherent with the problem-solving methodology, facilitate the teaching-learning process. For others, this process is facilitated when the professor is more demanding in contrast with the problem-solving approach. The professor-student relationship was facilitated by the establishment of bonds. Students did few comments about evaluation, indicating the need of a formative evaluation, which is a work in progress.

  20. Beyond the Soundtrack: Representing Music in Cinema, a cura di Daniel Goldmark, Lawrence Kramer e Richard Leppert, Berkeley, University of California Press, 2007

    OpenAIRE

    Francesco Finocchiaro

    2012-01-01

    Beyond the Soundtrack: Representing Music in Cinema (edited by Daniel Goldmark, Lawrence Kramer and Richard Leppert, Berkeley, University of California Press, 2007, viii-324 pp.) offers sixteen essays of various authors about film music. These papers were presented in 2004 in a study congress at the University of Minnesota. In introducing the book, the editors assert an assumption, today broadly accepted: indeed they affirm, that music has traditionally been regarded as a subordinate element ...