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Sample records for professionally applied topical

  1. Applied atomic and collision physics special topics

    CERN Document Server

    Massey, H S W; Bederson, Benjamin

    1982-01-01

    Applied Atomic Collision Physics, Volume 5: Special Topics deals with topics on applications of atomic collisions that were not covered in the first four volumes of the treatise. The book opens with a chapter on ultrasensitive chemical detectors. This is followed by separate chapters on lighting, magnetohydrodynamic electrical power generation, gas breakdown and high voltage insulating gases, thermionic energy converters, and charged particle detectors. Subsequent chapters deal with the operation of multiwire drift and proportional chambers and streamer chambers and their use in high energy p

  2. Risk assessment of topically applied products

    DEFF Research Database (Denmark)

    Søborg, Tue; Basse, Line Hollesen; Halling-Sørensen, Bent

    2007-01-01

    The human risk of harmful substances in semisolid topical dosage forms applied topically to normal skin and broken skin, respectively, was assessed. Bisphenol A diglycidyl ether (BADGE) and three derivatives of BADGE previously quantified in aqueous cream and the UV filters 3-BC and 4-MBC were used...... as model compounds. Tolerable daily intake (TDI) values have been established for BADGE and derivatives. Endocrine disruption was chosen as endpoint for 3-BC and 4-MBC. Skin permeation of the model compounds was investigated in vitro using pig skin membranes. Tape stripping was applied to simulate broken...... skin associated with various skin disorders. BADGE and derivatives had a tendency to permeate pig skin membranes in vitro with higher fluxes in the tape stripped membranes compared to the non-treated membranes. Data from the in vitro skin permeation study and from the literature were used as input...

  3. Topics in theoretical and applied statistics

    CERN Document Server

    Giommi, Andrea

    2016-01-01

    This book highlights the latest research findings from the 46th International Meeting of the Italian Statistical Society (SIS) in Rome, during which both methodological and applied statistical research was discussed. This selection of fully peer-reviewed papers, originally presented at the meeting, addresses a broad range of topics, including the theory of statistical inference; data mining and multivariate statistical analysis; survey methodologies; analysis of social, demographic and health data; and economic statistics and econometrics.

  4. Topically applied ceramide accumulates in skin glyphs

    Directory of Open Access Journals (Sweden)

    Zhang Q

    2015-07-01

    Full Text Available Qihong Zhang,1 Carol R Flach,1 Richard Mendelsohn,1 Guangru Mao,2 Apostolos Pappas,2 M Catherine Mack,2 Russel M Walters,2 Michael D Southall2 1Department of Chemistry, Rutgers University, Newark, 2Johnson & Johnson Consumer Companies, Inc., Skillman, NJ, USAAbstract: Ceramides (CERs, structural components of the stratum corneum (SC, impart essential barrier properties to this thin outer layer of the epidermis. Variations in CER species within this layer have been linked to several skin diseases. A recent proliferation of CER-containing topical skin-care products warrants the elucidation of CER penetration profiles in both healthy and diseased skin. In the current study, the spatial distributions of CER concentration profiles, following topical application of two species of CER, were tracked using infrared imaging. Suspensions of single-chain perdeuterated sphingosine and phytosphingosine CER in oleic acid were applied, in separate experiments, to the surface of healthy intact ex vivo human skin using Franz diffusion cells. Following either a 24- or 48-hour incubation period at 34°C, infrared images were acquired from microtomed skin sections. Both CER species accumulated in glyph regions of the skin and penetrated into the SC, to a limited extent, only in these regions. The concentration profiles observed herein were independent of the CER species and incubation time utilized in the study. As a result, a very heterogeneous, sparse, spatial distribution of CERs in the SC was revealed. In contrast, oleic acid was found to be fairly homogeneously distributed throughout the SC and viable epidermis, albeit at lower concentrations in the latter. A more uniform, lateral distribution of CERs in the SC would likely be important for barrier efficacy or enhancement.Keywords: stratum corneum, infrared imaging, topical delivery, oleic acid

  5. Applying Intersubjectivity for Professional Development

    Directory of Open Access Journals (Sweden)

    Uvaldina Montoya Janecek

    2016-03-01

    Full Text Available This is an intersubjective review of Loewen, G. V. (2012. Hermeneutic Pedagogy: Teaching and learning as dialogue and interpretation. Alcoa, TN, USA. Old Moon Academic Press. The four authors of the review used a reflective-reflexive, dialogic process to interpret and analyze Loewen’s text. Their review is presented in a dialogue format that resulted after analyzing a much longer set of narrative data.[1][1] Editorial Note: This is a very unusual review! There are four points of interest that make this review an interesting read. The first one concerns the subject of the review: the book on hermeneutics. The second point is the form of the review: it is dialogue between the authors presented in its development. The third point of interest is the personal nature of the contents: the authors masterly show how their work on the review of the book penetrates their lives thus showing the real life with its changes, happiness, sadness, struggles and tribulations. The last point of interest that makes this review worth to be read  is the pioneering character of the work behind this review. Glenda Moss used this review as a tool for professional development for the colleagues in her department. In my humble opinion, this review is the result of the very courageous, pioneering and inspirational work! (Mikhail Gradovski

  6. ECONOMIC ETHICS: APPLIED AND PROFESSIONAL CHARACTER

    Directory of Open Access Journals (Sweden)

    Ella Gordova

    2012-01-01

    Full Text Available In given article economic ethics are considered as set of norms of behavior of the businessman, the requirements shown by a cultural society to its style of work, to character of dialogue between participants of business, to their social shape. The conclusion becomes that economic ethics have applied character in relation to theoretical, to obschenormativnoy ethics, hence, represent section of applied ethics. On the other hand, the specific standard maintenance characterizes economic ethics as ethics professional.

  7. Topically applied glycyrrhizic acid causes hair removal in rats.

    Science.gov (United States)

    Ivosevic-Zaper, Julijana; Hofmann, Matthias; Kakadjanova, Ayna; Valesky, Eva; Meissner, Markus; Bereiter-Hahn, Jürgen; Kaufmann, Roland; Bernd, August; Kippenberger, Stefan

    2014-10-01

    Anecdotic reports from Turkmenistan suggest an epilatory effect of sweet licorice extract after topical application. This study examines hair removal after topical application of glycyrrhizic acid, the main compound of sweet licorice. An aqueous solution containing 15% of the ammonium salt of glycyrrhizic acid, 10% urea, and 20% ethanol was topically applied two times per day on the neck areas of Wistar rats using a toothbrush. After 3 d, 20-30% of the treated areas were free of hair. After treatment for 6-12 d, 90-95% of the hair was gone. Clinical as well as immunohistological examinations showed no signs of inflammation even after long-term treatment for more than 9 months. Interestingly, long-term treatment reduced the regrowth of hair of about 20%. Examination by scanning electron microscopy showed a smoothed hair cuticle that might facilitate detachment of the hair shaft from the follicular wall. Our findings suggest glycyrrhizic acid as an interesting molecule for treating hypertrichosis in humans.

  8. Enhancing the nail permeability of topically applied drugs.

    Science.gov (United States)

    Murdan, Sudaxshina

    2008-11-01

    The topical therapy of nail diseases, especially of onychomycosis, and to a smaller extent, of nail psoriasis, is desirable to avoid the side effects associated with their systemic therapy, to increase patient compliance and reduce the cost of treatment. Systemic therapy is however the mainstay of treatment due to the poor permeability of the nail plate to topically applied drugs. For effective topical therapy, ungual drug permeation must be enhanced. This can be achieved by disrupting the nail plate using physical techniques or chemical agents. Alternatively, drug permeation into the intact nail plate may be encouraged, for example, by iontophoresis or by formulating the drug within a vehicle which enables high drug partition out of the vehicle and into the nail plate. The physical techniques (manual and electrical nail abrasion, acid etching, ablation by lasers, microporation, application of low-frequency ultrasound and electric currents) and chemicals (thiols, sulphites, hydrogen peroxide, urea, water, enzymes) that have shown ungual enhancer activity are discussed in this review. Optimal drug formulation, while crucial to ungual drug delivery, is only briefly reviewed due to the limited literature.

  9. Topically applied azaphenothiazines inhibit contact sensitivity to oxazolone in mice.

    Science.gov (United States)

    Artym, Jolanta; Kocięba, Maja; Zaczyńska, Ewa; Zimecki, Michał; Jeleń, Małgorzata; Morak-Młodawska, Beata; Pluta, Krystian; Kaleta-Kuratewicz, Katarzyna; Madej, Jan P; Kuropka, Piotr; Kuryszko, Jan

    2017-07-27

    In this work we investigated the efficacy of two topically applied azaphenothiazine derivatives, 9-chloro-6-acetylaminobutylquinobenzo[3,2-b][1,4]thiazine (compound 4) and 6-chloroethylureidoethyldiquino[3,2-b;2';3'-e][1,4]thiazine (compound 5), in the amelioration of inflammatory symptoms of contact sensitivity (CS) to oxazolone in mice, in relation to the commercial ointment Protopic® (tacrolimus), the reference drug. The compounds were administered 24 h following elicitation of CS and, 24 h later, the parameters of inflammation, such as ear edema, blood composition, leukocyte level, numbers of cells in the draining lymph nodes, histological picture of the inflamed tissue, and the morphometric analysis, were analyzed. The study showed that the effectiveness of the studied azaphenothiazines applied as a 0.1% ointment was comparable to the reference drug regarding suppression of the inflammatory process, when all the investigated histological parameters are taken into account.

  10. Applying the Theory of Optimising Professional Life

    Directory of Open Access Journals (Sweden)

    Lesley Margaret Piko

    2014-12-01

    Full Text Available Glaser (2014 wrote that “the application of grounded theory (GT is a relatively neglected topic” (p. 1 in the literature. Applying GT to purposely intervene and improve a situation is an important adjunct to our knowledge and understanding of GT. A recent workshop of family doctors and general practitioners provides a useful example. The theory of optimising professional life explains that doctors are concerned about sustainment in their career and, to resolve this concern, they implement solutions to optimise their personal situation. Sustainment is a new, overarching concept of three needs: the need for self-care to sustain well-being, the need for work interest to sustain motivation, and the need for income to sustain lifestyle. The objective of the workshop was to empower doctors to reinvent their careers using this theory. Working individually and in small groups, participants were able to analyse a problem and to identify potential solutions.

  11. Drug delivery with topically applied nanoparticles: science fiction or reality.

    Science.gov (United States)

    Lademann, J; Richter, H; Meinke, M C; Lange-Asschenfeldt, B; Antoniou, C; Mak, W C; Renneberg, R; Sterry, W; Patzelt, A

    2013-01-01

    The efficacy of topically applied drugs is determined by their action mechanism and their potential capacity of passing the skin barrier. Nanoparticles are assumed to be efficient carrier systems for drug delivery through the skin barrier. For flexible nanoparticles like liposomes, this effect has been well demonstrated. The penetration properties of solid nanoparticles are currently under intensive investigation. The crucial advantage of nanoparticles over non-particulate substances is their capability to penetrate deeply into the hair follicles where they can be stored for several days. There is no evidence, yet, that solid particles ≥40 nm are capable of passing through the healthy skin barrier. Therefore and in spite of the long-standing research efforts in this field, commercially available solid nanoparticle-based products for drug delivery through the healthy skin are still missing. Nevertheless, the prospects for the clinical use of nanoparticles in drug delivery are tremendous. They can be designed as transport systems delivering drugs efficiently into the hair follicles in the vicinity of specific target structures. Once deposited at these structures, specific signals might trigger the release of the drugs and exert their effects on the target cells. In this article, examples of such triggered drug release are presented. © 2013 S. Karger AG, Basel.

  12. Topical applied nutraceutical antioxidant formulation reduces ocular oxidative stress

    OpenAIRE

    Peter F. Kador

    2017-01-01

    Oral nutraceutical antioxidants have shown disappointing clinical results in reducing oxidation-induced age-related cataract and other ocular diseases.Based on the hypothesis that nutraceuticals do not adequately reach the lens by oral administration, we have developed a unique topical antioxidant formulation whose active ingredients have the reported ability to reduce oxidative stress through free radical scavenging and chelating activity. This topical nutraceutical ...

  13. Identifying and Applying for Professional Development Funding.

    Science.gov (United States)

    Hyden, Christel; Escoffery, Cam; Kenzig, Melissa

    2015-07-01

    Participation in ongoing professional development can be critical for maintaining up-to-date knowledge in your field, as well as preparing for promotions and job changes. Career development activities may include formal classroom education, web-based courses, on-the-job training, workshops and seminars, professional conferences, and self-study programs. Developing a career development plan, cultivating a team to support your goals, and actively pursuing continuing education and skill-building opportunities are important across all career stages. However, the financial cost of these opportunities can often place them beyond reach. In this commentary, we summarize several potential sources for career development funding as well as best practices for completing the application process. © 2015 Society for Public Health Education.

  14. Topical applied nutraceutical antioxidant formulation reduces ocular oxidative stress

    Directory of Open Access Journals (Sweden)

    Peter F. Kador

    2017-01-01

    Full Text Available Oral nutraceutical antioxidants have shown disappointing clinical results in reducing oxidation-induced age-related cataract and other ocular diseases.Based on the hypothesis that nutraceuticals do not adequately reach the lens by oral administration, we have developed a unique topical antioxidant formulation whose active ingredients have the reported ability to reduce oxidative stress through free radical scavenging and chelating activity. This topical nutraceutical formulation was designed to mimic the in vivo activity of multifunctional antioxidants, compoundswhich arebeing developed in our laboratory toindependently scavenge free radicals and selectively bind redox metals.A comparison of the efficacy of this topical nutraceutical to multifunctional antioxidants in laboratory animal models of oxidation-induced lens changes, retinal changes,and dry eye is reviewed.Although it is less potent than the small molecule multifunctional antioxidants that will require FDA approval, the topical nutraceutical formulation beneficially reduces ocular oxidative stress.These studies suggest that this topical antioxidant may fill an unmet therapeutic need by providing a nutraceutical that beneficially reduces the effects of oxidation on age-related ocular diseases

  15. Signal integrity applied electromagnetics and professional practice

    CERN Document Server

    Russ, Samuel H

    2016-01-01

    This textbook teaches how to design working systems at very high frequencies. It is designed to introduce computer engineers to the design of extremely high speed digital systems. Combining an intuitive, physics-based approach to electromagnetics with a focus on solving realistic problems, the author presents concepts that are essential for computer and electrical engineers today. The book emphasizes an intuitive approach to electromagnetics, and then uses this foundation to show the reader how both physical phenomena can cause signals to propagate incorrectly; and how to solve commonly encountered issues. Emphasis is placed on real problems that the author has encountered in his professional career, integrating problem-solving strategies and real signal-integrity case studies throughout the presentation. Students are challenged to think about managing complex design projects and implementing successful engineering and manufacturing processes. Each chapter includes exercises to test concepts introduced.

  16. Methodology of students' professionally-applied physical training in universities

    Directory of Open Access Journals (Sweden)

    Pylypey L.P.

    2012-11-01

    Full Text Available Real system of physical education that exists in Ukraine is considered; the ineffectiveness of physical training of students for future life and production activities is shown. In modern conditions the structure of physiological requirements and working conditions is changing and, accordingly, there are additional requirements for professionally-applied physical training. The model of the educational process for credit-module system in high school is given. Theoretical and methodological reasoning of professionally-applied physical training methodology in university of economic profile is carried out. Management options for physical training of students are proposed. The systems of computer technology of professionally-applied physical training are considered.

  17. Penetration of boron from topically applied borate solutions

    Science.gov (United States)

    Stan T. Lebow; Patricia K. Lebow; Steven A. Halverson

    2010-01-01

    Borate penetration relies on diffusion when borate and glycol-borate preservatives are applied to the surface of wood. This study evaluated the extent of borate penetration in framing lumber as a function of preservative formulation, wood moisture content, and diffusion time after treatment. In Phase I of the study, end-matched specimens were conditioned to target...

  18. Topically applied caffeine induces miosis in the ketamine/xylazine anesthetized rat.

    Science.gov (United States)

    Kronschläger, Martin; Yu, Zhaohua; Talebizadeh, Nooshin; Meyer, Linda Maren; Söderberg, Per

    2014-10-01

    The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10 ketamine/xylazine anesthetized animals, while vehicle only was topically applied to the contralateral eye. In the second experiment, caffeine was topically applied to both eyes in one group of 10 ketamine/xylazine anesthetized rats, while in another group both eyes vehicle only was topically applied to both eyes. In both experiments pupil diameter was measured at 0, 10, 20, 40 and 60 min after topical application. In three of the animals, the pupil was dilated with tropicamide 5 mg/ml at 60 min after the topical application of caffeine and the pupil diameter was measured. The first experiment showed a relative miosis in caffeine treated eyes as compared to the vehicle treated eye, that changed over time. The second experiment in line with the first experiment, also showed that topically applied caffeine causes a relative miosis as compared to vehicle only that changes over time. Eyes treated with caffeine reacted with quick dilatation after tropicamide application. Topical caffeine antagonizes ketamine/xylazine anesthesia induced mydriasis in a time dependent manner. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Organization of professional and applied physical training and applied specifically oriented undergraduate students of forestry professions

    Directory of Open Access Journals (Sweden)

    Martirosova T.A.

    2012-11-01

    Full Text Available The questions of the use of facilities are examined professionally-applied physical preparation of students. The necessity of more rapid and high-quality mastering of certain labour abilities and skills, increase of the labour productivity, prophylaxis of professional diseases is marked. It is marked that forms and facilities of physical education of students of forestry specialities are determined features professionally-labour to activity of this industry. Employments of the special applied orientation are plugged in itself: theoretical employments, practical employments, sports and fitness measures, individual independent professionally-applied physical exercises, special applied types of sport. The features of forming professionally of important qualities of future specialist are certain in the process of physical education in the institute of higher.

  20. Inappropriate amounts of topical tacrolimus applied on Korean patients with eczema.

    Science.gov (United States)

    Jin, Hyunju; Kim, Jeong-Min; Kim, Gun-Wook; Kim, Hoon-Soo; Ko, Hyun-Chang; Kim, Moon-Bum; Kim, Byung-Soo

    2017-06-01

    The limited efficacy of topical tacrolimus may result from insufficient frequency of application or amount applied in eczema patients. To investigate the frequency of application and amount of use of topical tacrolimus in patients with various types of eczema. The frequency of application and the applied amount of topical tacrolimus were assessed over two weeks. A total of 200 eczema patients completed this study. The average number of applications per day was 1.75 ± 0.53, despite instructions to apply the topical tacrolimus twice daily. With respect to the frequency of application, 147 (73.5%) and 122 (61.0%) of patients followed the prescription in the first and second weeks, respectively. The average amount applied per 2% of total body surface area (TBSA) was 0.54 ± 0.52 g. Only 53 (26.5%) patients applied between 80 and 120% of expected amount of topical tacrolimus. The frequency of application was self-reported, possibly resulting in limited accuracy. Korean patients with eczema tend to apply topical tacrolimus less frequently and in inappropriate amounts. Clear instructions regarding both the frequency and amount of application are needed to improve the therapeutic outcome with treatment with topical tacrolimus.

  1. Transformation of Topic-Specific Professional Knowledge into Personal Pedagogical Content Knowledge through Lesson Planning

    Science.gov (United States)

    Stender, Anita; Brückmann, Maja; Neumann, Knut

    2017-01-01

    This study investigates the relationship between two different types of pedagogical content knowledge (PCK): the topic-specific professional knowledge (TSPK) and practical routines, so-called teaching scripts. Based on the Transformation Model of Lesson Planning, we assume that teaching scripts originate from a transformation of TSPK during lesson…

  2. Applying Constructionist Principles to Online Teacher Professional Development

    Directory of Open Access Journals (Sweden)

    Nathaniel Ostashewski

    2011-10-01

    Full Text Available This report explores the first iteration of a teacher professional development courselet grounded in constructionist theory and activities. This online teacher professional development (oTPD courselet provided opportunities for teachers to engage in just-in-time, ongoing TPD within a social networking site for educators. The topic of the oTPD was Robotics and Hands-on Activities in the Classroom. The courselet was designed for teachers who are interested in integrating constructionist pedagogies into their practice. Key findings of the first delivery of the oTPD courselet point to a need for flexible access, sharing of resources, and support for constructionist pedagogical activities as a PD value for participants. Findings further support the potential for an ongoing online community of practice around robotics in the classroom. The approach taken in this oTPD courselet of study continues to inform a model of oTPD delivery within a social-networking-enabled environment.

  3. Professional applied physical training of future specialists of agricultural production

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    Karabanov Y.A.

    2015-01-01

    Full Text Available Purpose : develop and experimentally prove the contents, methods and forms of physical training of future specialists of agricultural production. This takes into account advanced course of professional applied physical preparation means kettlebell sport. Material : The study involved 141 students. Duration of study is 5 years. Results : It was found that a significant increase in indicators of flexibility, strength, coordination abilities of students promoted the use of exercises using weights of different weights. Confirmed the legitimacy of the use of such means of physical education for the development of muscle strength of the upper body, back, legs, abdominals. These muscles are the most loaded in the performance of professional activities of mechanical engineers. Conclusions : The program meets the basic criteria for the formation of curriculum for physical education. The program promotes the development of professional applications of physical qualities, motor skills and improve physical performance of students.

  4. Subdermal penetration of topically applied clobetasol propionate in ointment base through intact human skin

    DEFF Research Database (Denmark)

    Petersen, Lars Jelstrup; Sindrup, J H; Kristensen, J K

    1992-01-01

    Some data have demonstrated a substantial subdermal accumulation of topically applied drugs in animals. The aim of this study was to evaluate a possible effect of epicutaneously applied clobetasol propionate on blood flow in human subcutaneous adipose tissue. Nine healthy subjects were studied...

  5. Lateral spreading of topically applied UV filter substances investigated by tape stripping.

    Science.gov (United States)

    Jacobi, U; Weigmann, H-J; Baumann, M; Reiche, A-I; Sterry, W; Lademann, J

    2004-01-01

    The lateral spreading of topically applied substances is a competitive process to the penetration into the stratum corneum (SC). The penetration of topically applied UV filter substances into the human SC and the lateral spreading were investigated in vivo. Tape stripping in combination with spectroscopic measurements was used to study both processes of two UV filter substances. The concentration of both UV filters was determined inside and outside the application area by varying the application and tape stripping protocol. A spreading of the topically applied substances from the treated to the untreated areas was observed, which caused a concentration gradient. This lateral spreading depends on the time between application and tape stripping and the size of the treated skin area. Significant amounts of topically applied substances were found adjoining the application area, due to the lateral spreading which takes place on the skin surface. In general, the lateral spreading must be considered to be a competitive process when studying penetration processes of topically applied substances. It has to be considered during drug treatment of small limited skin areas and for the interpretation of recovery rates obtained in penetration studies. Copyright 2004 S. Karger AG, Basel

  6. The Hirsch index applied to topics of interest to developing countries

    OpenAIRE

    Group, STIMULATE 6

    2007-01-01

    This article deals with an application of the h-index for topics. The h-index as defined by Hirsch is the number h such that, for a general group of papers, h papers received at least h citations while the other papers received no more than h citations. This definition has been extended by Banks to apply to topics. In this article the Web of Science, Google Scholar and Exalead are used to determine h-indices for topics of interest to developing countries. It is shown that there are important ...

  7. In vivo Raman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids

    Science.gov (United States)

    Lademann, J.; Caspers, P. J.; van der Pol, A.; Richter, H.; Patzelt, A.; Zastrow, L.; Darvin, M.; Sterry, W.; Fluhr, J. W.

    2009-01-01

    In the present study, the distribution of the carotenoids as a marker for the complete antioxidative potential in human skin was investigated before and after the topical application of carotenoids by in vivo Raman spectroscopy with an excitation wavelength of 785 nm. The carotenoid profile was assessed after a short term topical application in 4 healthy volunteers. In the untreated skin, the highest concentration of natural carotenoids was detected in different layers of the stratum corneum (SC) close to the skin surface. After topical application of carotenoids, an increase in the antioxidative potential in the skin could be observed. Topically applied carotenoids penetrate deep into the epidermis down to approximately 24 μm. This study supports the hypothesis that antioxidative substances are secreted via eccrine sweat glands and/or sebaceous glands to the skin surface. Subsequently they penetrate into the different layers of the SC.

  8. A new strategy to prevent chemotherapy and radiotherapy-induced alopecia using topically applied vasoconstrictor

    Science.gov (United States)

    Soref, Cheryl M.; Fahl, William E.

    2015-01-01

    In a new strategy, we sought to determine whether topically applied vasoconstrictor, with its accompanying transient skin hypoxia and exclusion of systemic drug, would prevent or suppress radiotherapy or chemotherapy-induced alopecia. Topical vasoconstrictor was applied to 1-cm2 skin patches on the backs of 10-day-old rats and minutes later they received either 7.1 gray (Gy) whole-body radiation or systemic N-nitroso-N-methylurea (MNU) or Cytoxan. The degree of alopecia was scored 10 days later by visual assessment (% coat retention) and hair follicle histologic analysis. Topical application of epinephrine or norepinephrine in an alcohol:water delivery vehicle induced clear skin blanch, and in a dose-dependent manner, topical epinephrine or norepinephrine (20–1,000 mM) applied before 7.1 Gy irradiation conferred 95% of coat retention in the treated skin patches versus 0% coat retention in vehicle controls, or in skin outside the treated patches. By histology, small numbers of dystrophic hair follicles were observed in hairless skin versus the normal density of anagen follicles in the immediately adjacent, drug-protected skin patches at day 20; protected coats were retained into adulthood. Topical epinephrine or norepinephrine before systemic MNU (30 ug/gm body weight) conferred up to 95% of coat retention in treated skin patches versus 0% coat retention elsewhere. Epinephrine-conferred % coat retention dropped to 16% in rats that received systemic Cytoxan, a drug whose plasma half-life is at least 8- to 10-fold longer than MNU. A general strategy is discussed for the use of topical epinephrine or norepinephrine in the clinic to provide an inexpensive and convenient strategy to prevent cancer therapy-induced alopecia. PMID:24811525

  9. Topically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinomas.

    Science.gov (United States)

    Singh, Anupama; Singh, Ashok; Sand, Jordan M; Bauer, Samuel J; Hafeez, Bilal Bin; Meske, Louise; Verma, Ajit K

    2015-04-01

    We present here that heat-shock protein 90 (Hsp90) inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17AAG), when topically applied to mouse skin, inhibits UVR-induced development of cutaneous squamous cell carcinoma (SCC). In these experiments, DMSO:acetone (1:40 v/v) solution of 17AAG (500 nmol) was applied topically to mouse skin in conjunction with each UVR exposure (1.8 kJ m(-2)). The UVR source was Kodacel-filtered FS-40 sun lamps (approximately 60% UVB and 40% UVA). In independent experiments with three separate mouse lines (SKH-1 hairless mice, wild-type FVB, and protein kinase C epsilon (PKCɛ)-overexpressing transgenic FVB mice), 17AAG treatment increased the latency and decreased both the incidence and multiplicity of UVR-induced SCC. Topical 17AAG alone or in conjunction with UVR treatments elicited neither skin nor systemic toxicity. 17AAG-caused inhibition of SCC induction was accompanied by a decrease in UVR-induced (1) hyperplasia, (2) Hsp90β-PKCɛ interaction, and (3) expression levels of Hsp90β, Stat3, pStat3Ser727, pStat3Tyr705, pAktSer473, and matrix metalloproteinase (MMP). The results presented here indicate that topical Hsp90 inhibitor 17AAG is effective in prevention of UVR-induced epidermal hyperplasia and SCC. One may conclude from the preclinical data presented here that topical 17AAG may be useful for prevention of UVR-induced inflammation and cutaneous SCC either developed in UVR-exposed or organ transplant population.

  10. Topically applied vitamin C increases the density of dermal papillae in aged human skin

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    Koop Urte

    2004-09-01

    Full Text Available Abstract Background The influence of ageing on the density of the functional entities of the papillae containing nutritive capillaries, here in terms as the papillary index, and the effect of topically applied vitamin C were investigated by confocal laser scanning microscopy (CLSM in vivo. Methods The age dependency of the papillary index was determined by CLSM on 3 different age groups. Additionally, we determined the effect of a topical cream containing 3% vitamin C against the vehicle alone using daily applications for four months on the volar forearm of 33 women. Results There were significant decreases in the papillary index showing a clear dependency on age. Topical vitamin C resulted in a significant increase of the density of dermal papillae from 4 weeks onward compared to its vehicle. Reproducibility was determined in repeated studies. Conclusions Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for partial corrections of the regressive structural changes associated with the aging process.

  11. 34 CFR 263.2 - Who is eligible to apply under the Professional Development program?

    Science.gov (United States)

    2010-07-01

    ... GRANT PROGRAMS Professional Development Program § 263.2 Who is eligible to apply under the Professional... 34 Education 1 2010-07-01 2010-07-01 false Who is eligible to apply under the Professional Development program? 263.2 Section 263.2 Education Regulations of the Offices of the Department of Education...

  12. THE IMPORTANCE OF APPLIED TO BIO-SECURITY PROFESSIONAL RADIOLOGY

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    Mauro Trevisan

    2013-09-01

    Full Text Available This study highlights the importance of biosecurity in the work of technicians and technologists in Radiology. As a means of motivation research, it was observed that despite the investment of the hospitals and clinics for the improvement of radiological techniques, little has been done to prevent the spread of diseases among the professionals in radiology. To do so, held the same direction by quantitatively and qualitatively, using the analytical method and a questionnaire as the technique of analysis, with the sample of 29 professionals located in public hospitals, the School LS and in private practice. The results demonstrated that there is knowledge of biosafety among radiology professionals, but there is no understanding of the relevance of the subject by some a good portion of them.

  13. Case histories of bald eagles and other raptors killed by organophosphorus insecticides topically applied to livestock

    Science.gov (United States)

    Henny, C.J.; Kolbe, E.J.; Hill, E.F.; Blus, L.J.

    1987-01-01

    Since 1982 when secondary poisoning of a red-tailed hawk (Buteo jamaicensis) was documented following the recommended use of famphur applied topically to cattle, the Patuxent Wildlife Research Center has tested dead birds of prey for poisoning by famphur and other pour-on organophosphorus (OP) insecticides. Brain cholinesterase (ChE) activity was first determined, then if ChE was depressed greater than or equal to 50%, stomach and/or crop contents were evaluated for anti-ChE compounds. This report presents the circumstances surrounding the OP-caused deaths of eight bald eagles (Haliaeetus leucocephalus), two red-tailed hawks, and one great horned owl (Bubo virginianus) between March 1984 and March 1985. OP poisoning of raptors by pour-on insecticides in the United States is widespread, but its magnitude is unknown.

  14. An Innovation Framework Applied to a Military Cyber Professionals Association

    Science.gov (United States)

    2013-09-01

    Associations, Military Cyber Professionals Association, Cyber Command, Innovation, Innovation Adoption, Innovation Model, Non Profit, Entrepreneur ...of such organizations is demonstrated by their pervasiveness, including across the American defense ecosystem . Examples of such military related...innovation. This narrative records observations and insights of interest to 15 innovators, entrepreneurs , intrapreneurs, extrapreneurs, policy makers, and

  15. Cashing In Stars: Does the Professional Ethic Apply in Retirement?

    Science.gov (United States)

    2015-01-01

    Congress and the public at large. As Melanie Sloan, executive director of CREW, mentions, the political and public apathy is attributed to the high...begin with the premise of military of- ficers as “professionals.” As students of civil-military relations are aware, Samuel Huntington’s The Soldier and

  16. The effect of topically applied tissue expanders on radial forearm skin pliability: a prospective self-controlled study

    OpenAIRE

    Chung, Jeffson; Bonaparte, James P; Odell, Michael; Corsten, Martin

    2014-01-01

    Background The use of pre-operatively applied topical tissue expansion tapes have previously demonstrated increased rates of primary closure of radial forearm free flap donor sites. This is associated with a reduced cost of care as well as improved cosmetic appearance of the donor site. Unfortunately, little is known about the biomechanical changes these tapes cause in the forearm skin. This study tested the hypothesis that the use of topically applied tissue expansion tapes will result in an...

  17. Protective effect of topically applied olive oil against photocarcinogenesis following UVB exposure of mice.

    Science.gov (United States)

    Budiyanto, A; Ahmed, N U; Wu, A; Bito, T; Nikaido, O; Osawa, T; Ueda, M; Ichihashi, M

    2000-11-01

    Reactive oxygen species have been shown to play a role in ultraviolet light (UV)-induced skin carcinogenesis. Vitamin E and green tea polyphenols reduce experimental skin cancers in mice mainly because of their antioxidant properties. Since olive oil has also been reported to be a potent antioxidant, we examined its effect on UVB-induced skin carcinogenesis in hairless mice. Extra-virgin olive oil was applied topically before or after repeated exposure of mice to UVB. The onset of UVB-induced skin tumors was delayed in mice painted with olive oil compared with UVB control mice. However, with increasing numbers of UVB exposures, differences in the mean number of tumors between UVB control mice and mice pretreated with olive oil before UVB exposure (pre-UVB group) were lost. In contrast, mice that received olive oil after UVB exposure (post-UVB group) showed significantly lower numbers of tumors per mouse than those in the UVB control group throughout the experimental period. The mean number of tumors per mouse in the UVB control, pre-UVB and post-UVB groups was 7.33, 6.69 and 2.64, respectively, in the first experiment, and 8.53, 9.53 and 3.36 in the second experiment. Camellia oil was also applied, using the same experimental protocol, but did not have a suppressive effect. Immunohistochemical analysis of DNA damage in the form of cyclobutane pyrimidine dimers (CPD), (6-4) photoproducts and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in samples taken 30 min after a single exposure of UVB showed no significant difference between UVB-irradiated control mice and the pre-UVB group. In the post-UVB group, there were lower levels of 8-OHdG in epidermal nuclei, but the formation of CPD and (6-4) photoproducts did not differ. Exposure of olive oil to UVB before application abrogated the protective effect on 8-OHdG formation. These results indicate that olive oil topically applied after UVB exposure can effectively reduce UVB-induced murine skin tumors, possibly via its

  18. Direction improvements professionally-applied physical preparation of students of economic specialities

    Directory of Open Access Journals (Sweden)

    Salatenko I.A.

    2012-12-01

    Full Text Available The aspects of improvement are considered professionally - the applied physical preparation of students of economic specialities taking into account the features of pedagogical process. It is set that in the process of professional - the applied physical preparation the complex of psychophysiological qualities, necessary a worker in his professional activity is successfully formed. The analysis of publications of the Russian and Ukrainian scientists is resulted about the varieties of facilities of improvement professionally - the applied physical preparation of students of higher educational establishments. Some features of professional preparation of future economists are found out. The necessity of search of new technologies of perfection of process of physical education of students is well-proven higher educational establishments of economic specialities. Directions of education the harmoniously developed personality of student are recommended, which will allow to improve a health, form important psychophysical qualities professionally.

  19. Topically Applied Vancomycin Powder Reduces the Rate of Surgical Site Infection in Diabetic Patients Undergoing Foot and Ankle Surgery.

    Science.gov (United States)

    Wukich, Dane K; Dikis, Jeffrey W; Monaco, Spencer J; Strannigan, Kristin; Suder, Natalie C; Rosario, Bedda L

    2015-09-01

    The purpose of this study was to evaluate the efficacy of topically applied vancomycin powder in reducing the rate of surgical site infections (SSIs) in patients with diabetes mellitus (DM) undergoing foot and ankle surgery. Eighty-one patients with DM who underwent reconstructive surgery of a foot and/or ankle deformity and/or trauma and who received topically applied vancomycin were matched to 81 patients with DM who did not receive topically applied vancomycin. The mean age was 60.6 years in the vancomycin group and 59.4 years in the control group (P infection was not significantly different between the 2 groups (OR, 0.400; 95% CI, 0.078-2.062; P = .2734); however, deep infections were 80% less likely in patients who received vancomycin powder (OR, 0.200; 95% CI, 0.044-0.913; P = .0377). High-risk diabetic patients undergoing foot and ankle surgery were notably less likely to develop an SSI with the use of topically applied vancomycin powder in the surgical wound, particularly with regard to deep infections. Topically applied vancomycin was associated with a very low rate of complications and was inexpensive ($5 per 1000 mg). Based on this study, foot and ankle surgeons may consider applying 500 to 1000 mg of vancomycin powder prior to skin closure in diabetic patients who are not allergic to vancomycin. Level III, retrospective case control series. © The Author(s) 2015.

  20. Ocular penetration of topically applied norfloxacin 0.3% in the rabbits and in humans.

    Science.gov (United States)

    Bron, A M; Péchinot, A; Garcher, C; Guyonnet, G; Kazmierczak, A

    1992-01-01

    The kinetics of topically applied norfloxacin 0.3 percent were studied in rabbit and man. All measurements were performed by high-pressure liquid chromatography. Norfloxacin concentrations were investigated five to 120 minutes in rabbit ocular tissues after instillation of a single drop. In normal eyes, after 30 minutes, mean +/- SEM levels were 14.3 +/- 3.7 micrograms/g in cornea, 3.3 +/- 0.7 micrograms/g in conjunctiva, 0.2 +/- 0.1 microgram/g in aqueous humor. After removal of the corneal epithelium concentrations were as follows: 84.2 +/- 15.8 micrograms/g, 7.3 +/- 2.3 micrograms/g, 8.6 +/- 1.9 micrograms/g respectively. Penetration in posterior ocular tissues were rather poor. In human eyes, the intracorneal concentrations were assessed in patients being operated on corneal grafts. After instillation of 5 drops, the concentration in cornea was 15.5 +/- 2.1 micrograms/g. These data show that therapeutic levels of norfloxacin can be achieved in anterior ocular tissues, which may be of help in superficial infections of the eye.

  1. Formulation Study of Topically Applied Lotion: In Vitro and In Vivo Evaluation

    Directory of Open Access Journals (Sweden)

    Syed Nisar Hussain Shah

    2013-01-01

    Full Text Available ntroduction: This article presents the development and evaluation of a new topical formulation of diclofenac diethylamine (DDA as a locally applied analgesic lotion. Methods: To this end, the lotion formulations were formulated with equal volume of varying concentrations (1%, 2%, 3%, 4%; v/v of permeation enhancers, namely propylene glycol (PG and turpentine oil (TO. These lotions were subjected to physical studies (pH, viscosity, spreadability, homogeneity, and accelerated stability, in vitro permeation, in vivo animal studies and sensatory perception testing. In vitro permeation of DDA from lotion formulations was evaluated across polydimethylsiloxane membrane and rabbit skin using Franz cells. Results: It was found that PG and TO content influenced the permeation of DDA across model membranes with the lotion containing 4% v/v PG and TO content showed maximum permeation enhancement of DDA. The flux values for L4 were 1.20±0.02 μg.cm-2.min-1 and 0.67 ± 0.02 μg.cm-2.min-1 for polydimethylsiloxane and rabbit skin, respectively. Flux values were significantly different (p < 0.05 from that of the control. The flux enhancement ratio of DDA from L4 was 31.6-fold and 4.8-fold for polydimethylsiloxane and rabbit skin, respectively. In the in vivo animal testing, lotion with 4% v/v enhancer content showed maximum anti-inflammatory and analgesic effect without inducing any irritation. Sensatory perception tests involving healthy volunteers rated the formulations between 3 and 4 (values ranging between -4 to +4, indicating a range of very bad to excellent, respectively. Conclusion: It was concluded that the DDA lotion containing 4% v/v PG and TO exhibit the best performance overall and that this specific formulation should be the basis for further clinical investigations.

  2. GEodesy Tools for Societal Issues (GETSI): Undergraduate curricular modules that feature geodetic data applied to critical social topics

    Science.gov (United States)

    Douglas, B. J.; Pratt-Sitaula, B.; Walker, B.; Miller, M. S.; Charlevoix, D.

    2014-12-01

    The GETSI project is a three-year NSF funded project to develop and disseminate teaching and learning materials that feature geodesy data applied to critical societal issues such as climate change, water resource management, and natural hazards (http://serc.carleton.edu/getsi). GETSI was born out of requests from geoscience faculty for more resources with which to educate future citizens and future geoscience professionals on the power and breadth of geodetic methods to address societally relevant topics. Development of the first two modules started at a February 2014 workshop and initial classroom testing begins in fall 2014. The Year 1 introductory module "Changing Ice and Sea Level" includes geodetic data such as gravity, satellite altimetry, and GPS time series. The majors-level Year 1 module is "Imaging Active Tectonics" and it has students analyzing InSAR and LiDAR data to assess infrastructure vulnerability to demonstratively active faults. Additional resources such as animations and interactive data tools are also being developed. The full modules will take about two weeks of class time; module design will permit portions of the material to be used as individual projects or assignments of shorter duration. Ultimately a total of four modules will be created and disseminated, two each at the introductory and majors-levels. GETSI is working in tight partnership with the Science Education Resource Center's (SERC) InTeGrate project on the module development, assessment, and dissemination to ensure compatibility with the growing number of resources for geoscience education. This will allow for an optimized module development process based on successful practices defined by these earlier efforts.

  3. Evidence of anti-inflammatory effect and percutaneous penetration of a topically applied fish oil preparation: a photoacoustic spectroscopy study

    Science.gov (United States)

    Ames, Franciele Q.; Sato, Francielle; de Castro, Lidiane V.; de Arruda, Laura L. M.; da Rocha, Bruno A.; Cuman, Roberto K. N.; Baesso, Mauro L.; Bersani-Amado, Ciomar A.

    2017-05-01

    This paper investigates the topical anti-inflammatory effect of a fish oil preparation (FOP) in a croton oil (CO) model of skin inflammation. The photoacoustic spectroscopy (PAS) was applied to estimate the percutaneous penetration of the FOP and as a model to evaluate the topical inflammatory response. After applying CO, the groups of mice received a topical application of a FOP on the left ear. The right ear received the vehicle that was used to dilute the CO. After 6 h, ear tissue was collected to determine the percent inhibition of edema, myeloperoxidase (MPO) activity, and cytokine levels and to perform PAS measurements. Treatment with FOP reduced edema and MPO activity, which was at least partially attributed to a decrease in the levels of tumor necrosis factor, interleukin-1β, interleukin-6, keratinocyte-derived chemokine, and monocyte chemoattractant protein-1. The topically applied FOP penetrated into the tissue and decreased the area of the bands that characterize inflamed tissue. The present results demonstrated the topical anti-inflammatory effect of the FOP. PAS suggests that FOP anti-inflammatory activity is linked with its ability to penetrate through the skin.

  4. Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice.

    Science.gov (United States)

    Ireland, Demelza J; Greay, Sara J; Hooper, Cornelia M; Kissick, Haydn T; Filion, Pierre; Riley, Thomas V; Beilharz, Manfred W

    2012-08-01

    Melaleuca alternifolia (tea tree) oil (TTO) applied topically in a dilute (10%) dimethyl sulphoxide (DMSO) formulation exerts a rapid anti-cancer effect after a short treatment protocol. Tumour clearance is associated with skin irritation mediated by neutrophils which quickly and completely resolves upon treatment cessation. To examine the mechanism of action underlying the anti-cancer activity of TTO. Immune cell changes in subcutaneous tumour bearing mice in response to topically applied TTO treatments were assessed by flow cytometry and immunohistochemistry. Direct cytotoxicity of TTO on tumour cells in vivo was assessed by transmission electron microscopy. Neutrophils accumulate in the skin following topical 10% TTO/DMSO treatment but are not required for tumour clearance as neutrophil depletion did not abrogate the anti-cancer effect. Topically applied 10% TTO/DMSO, but not neat TTO, induces an accumulation and activation of dendritic cells and an accumulation of T cells. Although topical application of 10% TTO/DMSO appears to activate an immune response, anti-tumour efficacy is mediated by a direct effect on tumour cells in vivo. The direct cytotoxicity of TTO in vivo appears to be associated with TTO penetration. Future studies should focus on enhancing the direct cytotoxicity of TTO by increasing penetration through skin to achieve a higher in situ terpene concentration. This coupled with boosting a more specific anti-tumour immune response will likely result in long term clearance of tumours. Copyright © 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.

  5. Effect of Topical and Intravenously Applied Tranexamic Acid Compared to Control Group on Bleeding in Primary Unilateral Total Knee Arthroplasty.

    Science.gov (United States)

    Uğurlu, Mahmut; Aksekili, Mehmet Atıf Erol; Çağlar, Ceyhun; Yüksel, Kağan; Şahin, Ercan; Akyol, Mesut

    2017-02-01

    We aimed to answer the following three questions in this study: (1) Does tranexamic acid (TA) reduce the amount of bleeding in total knee arthroplasty (TKA)? (2) Does TA reduce requirement for blood transfusion? (3) Is there any difference on reliability and efficacy between topical and intravenous (IV) applications of TA? Patients were allocated into three groups randomly by a software program as topical, IV, and control group. TA was applied as 20 mg/kg to the IV group and as 3 g/100 mL saline to the topical group. The hemoglobin values were recorded preoperatively and postoperatively on the same day and on day 1 and day 2. Removal of the drain postoperatively and length of hospital stay, as well as any complications such as pulmonary embolism or deep venous thrombosis, were also noted. The study comprised 40 patients in the IV group, 42 in the topical group, and 41 in the control group. The drain output values were similar in the IV and topical groups (p = 0.161), while those of the control group were significantly higher than both the IV and topical groups (p control group, 4.8% in the topical group, and 5.1% of the IV group (χ2 = 6.522; p = 0.038). The results of the study showed that 20 mg/kg single-dose IV bolus or 3 g topical TA application reduced blood loss and transfusion requirement without increasing the rate of thromboembolic complications in unilateral primary TKA. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  6. Photocarcinogenicity of selected topically applied dermatological drugs: calcineurin inhibitors, corticosteroids, and vitamin D analogs

    Directory of Open Access Journals (Sweden)

    Catharina Margrethe Lerche

    2010-09-01

    Full Text Available Topical therapies constitute the mainstay of dermatological treatments for skin disorders, such as atopic dermatitis, contact dermatitis, psoriasis, or acne. Since some of these diseases are often chronic, treatment duration may last for years and may even last the patient’s entire lifetime. Obviously, such long-term therapy may raise safety concerns, which also include the potential photocarcinogenic effect. Most patients are exposed to ultraviolet radiation (UVR during leisure, work, vacations, or in tanning beds. Additionally, the patients may receive UVR via UVB phototherapy or psoralens plus UVA radiation (PUVA. The use of immunosuppressant’s, such as corticosteroids and calcineurin inhibitors, has markedly increased. Patients with skin diseases have benefited from both systemic and topical treatment of both new and established drugs. The issue of a black box warning by the US Food and Drug Administration has increased concerns about photocarcinogenesis, which raises the question: “Are these drugs safe?” This review focuses on the mechanism of action and photocarcinogenic potential of commonly used topical treatments, such as corticosteroids, calcineurin inhibitors, and vitamin D analogs.

  7. Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, E.R.

    1986-06-01

    Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy. There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma. Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued. His serum potassium level normalized despite continuation of the prednisone therapy. He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal. This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation.

  8. The impact of professional-applied physical training to develop students' performance

    Directory of Open Access Journals (Sweden)

    Kirko Gennadij Aleksandrovich

    2011-10-01

    Full Text Available It is reviewed publications on physical education of youth and professional-applied physical training of students of economic universities. The experiment involved 256 students. Determined by means of professional-applied physical training to develop physical fitness and health. The article traces the changes that occur in the body as a result of systematic and substantial physical exercise. Shows the dynamics of development of motor abilities of students of basic medical offices I-II courses for two years of training.

  9. APA Award for Distinguished Professional Contributions to Applied Research: Cameron J. Camp.

    Science.gov (United States)

    2017-12-01

    The Award for Distinguished Professional Contributions to Applied Research is given to a psychologist whose research has led to important discoveries or developments in the field of applied psychology. The 2017 recipient is Cameron J. Camp, whose innovative programs have informed psychologists in working with dementia patients to improve their living skills and enhance their independence. Camp's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  10. Leslie S. Greenberg: Award for Distinguished Professional Contributions to Applied Research

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents a short biography of the 2012 winner of the American Psychological Association's Award for Distinguished Professional Contributions to Applied Research. Leslie S. Greenberg is an exemplary scientist-practitioner whose pioneering work has significantly altered the landscape of the field of psychotherapy research and practice. His seminal…

  11. Professionally applied fluoride gel in low-caries 10.5-year-olds.

    NARCIS (Netherlands)

    Truin, G.J.; Hof, M.A. van 't

    2005-01-01

    The question has been raised whether low-caries children regularly using fluoride toothpaste will benefit from the professional application of additional fluoride gel. To investigate the caries-reducing effect of semi-annually-applied neutral 1% sodium fluoride gel, we carried out a double-blind

  12. Applying Program Theory-Driven Approach to Design and Evaluate a Teacher Professional Development Program

    Science.gov (United States)

    Lin, Su-ching; Wu, Ming-sui

    2016-01-01

    This study was the first year of a two-year project which applied a program theory-driven approach to evaluating the impact of teachers' professional development interventions on students' learning by using a mix of methods, qualitative inquiry, and quasi-experimental design. The current study was to show the results of using the method of…

  13. Laser-induced thermal coagulation enhances skin uptake of topically applied compounds

    DEFF Research Database (Denmark)

    Haak, C S; Hannibal, J; Paasch, U

    2017-01-01

    BACKGROUND: Ablative fractional laser (AFL) generates microchannels in skin surrounded by a zone of thermally altered tissue, termed the coagulation zone (CZ). The thickness of CZ varies according to applied wavelength and laser settings. It is well-known that AFL channels facilitate uptake...

  14. Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy

    Science.gov (United States)

    Wang, Yu; Kang, Soyoung; Khan, Altaz; Ruttner, Gabriel; Leigh, Steven Y.; Murray, Melissa; Abeytunge, Sanjee; Peterson, Gary; Rajadhyaksha, Milind; Dintzis, Suzanne; Javid, Sara; Liu, Jonathan T. C.

    2016-02-01

    There is a need to image excised tissues during tumor-resection procedures in order to identify residual tumors at the margins and to guide their complete removal. The imaging of dysregulated cell-surface receptors is a potential means of identifying the presence of diseases with high sensitivity and specificity. However, due to heterogeneities in the expression of protein biomarkers in tumors, molecular-imaging technologies should ideally be capable of visualizing a multiplexed panel of cancer biomarkers. Here, we demonstrate that the topical application and quantification of a multiplexed cocktail of receptor-targeted surface-enhanced Raman scattering (SERS) nanoparticles (NPs) enables rapid quantitative molecular phenotyping (QMP) of the surface of freshly excised tissues to determine the presence of disease. In order to mitigate the ambiguity due to nonspecific sources of contrast such as off-target binding or uneven delivery, a ratiometric method is employed to quantify the specific vs. nonspecific binding of the multiplexed NPs. Validation experiments with human tumor cell lines, fresh human tumor xenografts in mice, and fresh human breast specimens demonstrate that QMP imaging of excised tissues agrees with flow cytometry and immunohistochemistry, and that this technique may be achieved in less than 15 minutes for potential intraoperative use in guiding breast-conserving surgeries.

  15. Educational topics for school from the perspective of professionals in the Mobile Emergency Service.

    Science.gov (United States)

    Mota, Larissa Larie; Andrade, Selma Regina de

    2016-06-01

    To systematize, with professionals from the Mobile Emergency Care Service of Santa Catarina municipality, the main issues for the development of an educational tool of attention to the emergency room, dedicated to the school-age population. Qualitative study, conducted through meetings in the focus group format, with 19 professionals who develop their activities in the city Emergency Mobile Emergency Service. Data were categorized and analyzed using thematic analysis technique. The contents discussed at the meetings were grouped into four thematic categories: The Mobile Emergency Service and the school: education and health promotion for children; As the Mobile Emergency Care Service works: What is important to know ?; Something's wrong, what now? and; We are nearly finished, give your opinion. The specific issues arising from the meetings contributed to the production of an educational tool on the activities of the Mobile Emergency Service, which may be used by the School Health Program to promote health education in the care area to the emergency room with the population schoolchildren. Sistematizar, junto aos profissionais do Serviço de Atendimento Móvel de Urgência de um município catarinense, os principais temas para a elaboração de um instrumento educativo sobre atenção às urgências, dedicado à população em idade escolar. Estudo qualitativo, realizado por meio de encontros no formato de grupo focal, com 19 profissionais que desenvolvem suas atividades no Serviço de Atendimento Móvel de Urgência municipal. Os dados foram categorizados e analisados com a técnica de análise temática. Os conteúdos debatidos nos encontros foram agrupados em quatro categorias temáticas: O Serviço de Atendimento Móvel de Urgência e a escola: educação e promoção da saúde para as crianças; Como o Serviço de Atendimento Móvel de Urgência funciona: o que é importante saber?; Tem algo errado, e agora? e; Estamos quase concluindo, dê sua opinião. Os

  16. Applied mechanics and mechatronics special topic volume with invited peer reviewed papers only

    CERN Document Server

    Trebuňa, František

    2014-01-01

    The issue ""Applied Mechanics and Mechatronics"" contains results of research from researchers and designers from several prominent universities and research institutes of Central Europe.The publication is divided into three following chapters: Modeling and Simulation of Mechanic and Mechatronic SystemsAnalysis and Design of Mechanic and Mechatronic SystemsExperimental methods in Mechanics and Mechatronics. The submitted publication provides insight on modern approaches and methods in designing, modeling and experimental analyzing of mechanic and mechatronics systems.

  17. The effect of topically applied tissue expanders on radial forearm skin pliability: a prospective self-controlled study.

    Science.gov (United States)

    Chung, Jeffson; Bonaparte, James P; Odell, Michael; Corsten, Martin

    2014-04-16

    The use of pre-operatively applied topical tissue expansion tapes have previously demonstrated increased rates of primary closure of radial forearm free flap donor sites. This is associated with a reduced cost of care as well as improved cosmetic appearance of the donor site. Unfortunately, little is known about the biomechanical changes these tapes cause in the forearm skin. This study tested the hypothesis that the use of topically applied tissue expansion tapes will result in an increase in forearm skin pliability in patients undergoing radial forearm free flap surgery. Twenty-four patients scheduled for head and neck surgery requiring a radial forearm free flap were enrolled in this prospective self-controlled observational study. DynaClose tissue expansion tapes (registered Canica Design Inc, Almonte, Canada) were applied across the forearm one week pre-operatively. Immediately prior to surgery, the skin pliability of the dorsal and volar forearm sites were measured with the Cutometer MPA 580 (registered Courage-Khazaka Electronic GmbH, Cologne, Germany) on both the treatment and contralateral (control) arms. Paired t-tests were used to compare treatment to control at both sites, with p definition of clinical significance.

  18. Dermal bioaccessibility of flame retardants from indoor dust and the influence of topically applied cosmetics.

    Science.gov (United States)

    Pawar, Gopal; Abdallah, Mohamed Abou-Elwafa; de Sáa, Eugenia Villaverde; Harrad, Stuart

    2017-01-01

    Despite extensive literature on their potential adverse health effects, there is a lack of information on human dermal exposure to organic flame retardant chemicals (FRs). This study applies an in vitro physiologically based extraction test to provide new insights into the dermal bioaccessibility of various FRs from indoor dust to synthetic sweat/sebum mixture (SSSM). The bioaccessible fractions of α-, β- and γ-hexabromocyclododecane (HBCD) and tetrabromobisphenol A (TBBPA) to 1:1 (sweat/sebum) mixture were 41%, 47%, 50% and 40%, respectively. For Tris-2-chloroethyl phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCIPP) and tris-1,3-dichloropropyl phosphate (TDCIPP), bioaccessible fractions were 10%, 17% and 19%. Composition of the SSSM and compound-specific physicochemical properties were the major factors influencing the bioaccessibility of target FRs. Except for TBBPA, the presence of cosmetics (moisturising cream, sunscreen lotion, body spray and shower gel) had a significant effect (Pcosmetics decreased the bioaccessibility of HBCDs from indoor dust, whereas shower gel and sunscreen lotion enhanced the bioaccessibility of target PFRs. Our bioaccessibility data were applied to estimate the internal exposure of UK adults and toddlers to the target FRs via dermal contact with dust. Our worst-case scenario exposure estimates fell far below available health-based limit values for TCEP, TCIPP and TDCIPP. However, future research may erode the margin of safety for these chemicals.

  19. Structural-functional model of medical students’ professional-applied physical training

    Directory of Open Access Journals (Sweden)

    A.V. Petryshyn

    2016-10-01

    Full Text Available Purpose: to work out and experimentally prove model of professional-applied physical training of medical higher educational establishments’ students. Material: in the research 80 students participated. In questioning physical education instructors of medical higher education establishments (n=20 participated. Results: influence of students’ professionally important characteristics on general physical fitness indicators and functional state has been shown. Directions of students’ physical fitness parameters’ individual diagnostic and control over physical education effectiveness have been offered. Volumes of physical exercises in the structure of training have been found: special training (15-20% and competition exercises (20-30%. Conclusions: the need in raising the level of professionally important for students’ abilities has been noted: speed power, static power endurance, power endurance, coordination of arms’ movements, static balance.

  20. [Emergent topics of educators' perspectives on their own education for retired health care professionals].

    Science.gov (United States)

    Lourdes, C; Reus, Velázquez

    2002-09-01

    The purpose of the study was to explore the nature of seven retired educators' perspectives on their own education. Each educator was from a different health profession. Berger and Luckmann's thesis on the social construction of reality served as the conceptual framework of the study Throughout the study the researcher was able to appreciate that even though the reality of everyday life is a subjective interpretation of the world, there is a continuous correspondence between the researcher's perceptions of meaning and those of others. The in-depth interview method provided an adequate mechanism for the reconstruction of participants' everyday life experiences, and for the construction of categories of meaning. The researcher applied the method of inductive analysis in the identification of the themes and issues and in the construction of the categories. Nine categories of meaning emerged from the participants' reconstruction: 1) the legitimization of retirement; 2) understandings surrounding one's education; 3) understanding of the human aging process; 4) the legitimization of death; 5) the bonds between human beings as a fundamental element of human reality; 6) the roles within, and the objectification of, human activity; 7) the legitimization of religion and the element of spirituality; 8) understandings surrounding one's self; and 9) the reconstruction of the past: traditions and legitimate practices. Within the categories are areas of convergence between the signification of "one's own education" as a modality of life, and the signification of learning and of its propitiatory and restrictive conditions. As to the understandings of meaning and the emergent categories of meaning, the researcher constructed specific educational recommendations, which emphasize the educational processes of the old adult.

  1. Effect of topically applied sildenafil citrate on wound healing: experimental study

    Directory of Open Access Journals (Sweden)

    Koray Gürsoy

    2014-08-01

    Full Text Available Wound healing is a complex process that necessitates organization of different cell types and several signalling molecules. The aim of this study is to evaluate the effect of different concentrations of sildenafil citrate, which decreases cGMP degradation, on wound healing by secondary intention.This study was performed using 25 Sprague Dawley rats weighing 200-250 grams. 4 dorsal defects were created. Four different treatment modalities which were 1% and 5% sildenafil citrate gel prepared with carbopol, pure carbopol gel without any drug in it and 0,9% NaCl solution; were applied to each lesion of the same rat. Randomly selected five rats (25 rats in total were sacrificed on 3rd, 5th, 7th, 10th, and 14th days; and the effect of each modality was evaluated by means of defect area measurement, histopathological examination and measurement of tissue hydroxyproline levels.Sildenafil citrate gel application decreased the defect areas in a dose independent manner starting from 3rd day and dose dependent manner after 7th day. By means of vascularization, sildenafil citrate increased vascularity starting from 3rd day. The strength of acute inflammation was superior in sildenafil groups starting from 5th day; and the amount and maturation of granulation in the wound bed, as well as the strength of chronic inflammation were superior in defects treated with sildenafil citrate as early as 7th day.

  2. Effect of topically applied sildenafil citrate on wound healing: experimental study

    Science.gov (United States)

    Gürsoy, Koray; Oruç, Melike; Kankaya, Yüksel; Ulusoy, M. Gürhan; Koçer, Uğur; Kankaya, Duygu; Gürsoy, R. Neslihan; Çevik, Özge; Öğüş, Elmas; Fidanci, Vildan

    2014-01-01

    Wound healing is a complex process that necessitates organization of different cell types and several signalling molecules. The aim of this study is to evaluate the effect of different concentrations of sildenafil citrate, which decreases cGMP degradation, on wound healing by secondary intention. This study was performed using 25 Sprague Dawley rats weighing 200-250 grams. 4 dorsal defects were created. Four different treatment modalities which were 1% and 5% sildenafil citrate gel prepared with carbopol, pure carbopol gel without any drug in it and 0,9% NaCl solution; were applied to each lesion of the same rat. Randomly selected five rats (25 rats in total) were sacrificed on 3rd, 5th, 7th, 10th, and 14th days; and the effect of each modality was evaluated by means of defect area measurement, histopathological examination and measurement of tissue hydroxyproline levels. Sildenafil citrate gel application decreased the defect areas in a dose independent manner starting from 3rd day and dose dependent manner after 7th day. By means of vascularization, sildenafil citrate increased vascularity starting from 3rd day. The strength of acute inflammation was superior in sildenafil groups starting from 5th day; and the amount and maturation of granulation in the wound bed, as well as the strength of chronic inflammation were superior in defects treated with sildenafil citrate as early as 7th day. PMID:25172969

  3. Topically Applied Epsilon-Aminocaproic Acid Reduces Blood Loss and Length of Hospital Stay After Total Knee Arthroplasty.

    Science.gov (United States)

    Harper, Robert A; Sucher, Mark G; Giordani, Mauro; Nedopil, Alexander J

    2017-11-01

    Perioperative blood loss after total knee arthroplasty (TKA) affects postoperative recovery. Tranexamic acid is safe and efficient in reducing blood loss without increasing thromboembolic events. Epsilon-aminocaproic acid (ε-ACA) is less expensive than and as safe as tranexamic acid. Its efficiency when locally applied in TKA is unknown. The authors retrospectively followed 240 consecutive patients treated by 1 surgeon with TKA from January 2012 to August 2016. From January 2013 to May 2015, the authors topically applied 5 g of ε-ACA to the open wound after tourniquet release and before closure (ε-ACA-after-tourniquet-release group). From August 2015 to August 2016, the authors topically applied 5 g of ε-ACA intraoperatively to the open wound 3 minutes before tourniquet release (ε-ACA-before-tourniquet-release group). The last 80 patients not receiving ε-ACA (control group), the 80 patients in the ε-ACA-after-tourniquet-release group, and the 80 patients in the ε-ACA-before-tourniquet-release group were compared regarding blood loss, treatment costs, and thromboembolic complications. The mean±SD calculated blood loss was 1478.8±367.1 mL for the control group, 1424.0±249.3 mL for the ε-ACA-after-tourniquet-release group, and 1052.3±419.1 mL for the ε-ACA-before-tourniquet-release group (P<.05). Using ε-ACA before tourniquet release reduced the length of hospital stay by 0.7 days (P<.05) compared with not using ε-ACA, leading to cost savings of $1547.37 per patient. One patient in the ε-ACA-before-tourniquet-release group and 1 patient in the control group developed a venous thromboembolism in the postoperative period. Epsilon-aminocaproic acid significantly reduces blood loss after TKA when topically applied before tourniquet release. Its application reduced costs by decreasing the length of hospital stay and did not increase thromboembolic events. [Orthopedics. 2017; 40(6):e1044-e1049.]. Copyright 2017, SLACK Incorporated.

  4. Therapeutic Efficacy of Topically Applied Antioxidant Medicinal Plant Extracts in a Mouse Model of Experimental Dry Eye

    Science.gov (United States)

    Lee, Jee Bum; Li, Ying; Choi, Ji Suk; Lee, Hyo Seok

    2016-01-01

    Purpose. To investigate the therapeutic effects of topical administration of antioxidant medicinal plant extracts in a mouse model of experimental dry eye (EDE). Methods. Eye drops containing balanced salt solution (BSS) or 0.001%, 0.01%, and 0.1% extracts were applied for the treatment of EDE. Tear volume, tear film break-up time (BUT), and corneal fluorescein staining scores were measured 10 days after desiccating stress. In addition, we evaluated the levels of interleukin- (IL-) 1β, tumor necrosis factor- (TNF-) α, IL-6, interferon- (IFN-) γ, and IFN-γ associated chemokines, percentage of CD4+C-X-C chemokine receptor type 3 positive (CXCR3+) T cells, goblet cell density, number of 4-hydroxy-2-nonenal (4-HNE) positive cells, and extracellular reactive oxygen species (ROS) production. Results. Compared to the EDE and BSS control groups, the mice treated with topical application of the 0.1% extract showed significant improvements in all clinical parameters, IL-1β, IL-6, TNF-α, and IFN-γ levels, percentage of CD4+CXCR3+ T cells, goblet cell density, number of 4-HNE-positive cells, and extracellular ROS production (P extracts improved clinical signs, decreased inflammation, and ameliorated oxidative stress marker and ROS production on the ocular surface of the EDE model mice. PMID:27313829

  5. Facial Cosmetics and Attractiveness: Comparing the Effect Sizes of Professionally-Applied Cosmetics and Identity.

    Science.gov (United States)

    Jones, Alex L; Kramer, Robin S S

    2016-01-01

    Forms of body decoration exist in all human cultures. However, in Western societies, women are more likely to engage in appearance modification, especially through the use of facial cosmetics. How effective are cosmetics at altering attractiveness? Previous research has hinted that the effect is not large, especially when compared to the variation in attractiveness observed between individuals due to differences in identity. In order to build a fuller understanding of how cosmetics and identity affect attractiveness, here we examine how professionally-applied cosmetics alter attractiveness and compare this effect with the variation in attractiveness observed between individuals. In Study 1, 33 YouTube models were rated for attractiveness before and after the application of professionally-applied cosmetics. Cosmetics explained a larger proportion of the variation in attractiveness compared with previous studies, but this effect remained smaller than variation caused by differences in attractiveness between individuals. Study 2 replicated the results of the first study with a sample of 45 supermodels, with the aim of examining the effect of cosmetics in a sample of faces with low variation in attractiveness between individuals. While the effect size of cosmetics was generally large, between-person variability due to identity remained larger. Both studies also found interactions between cosmetics and identity-more attractive models received smaller increases when cosmetics were worn. Overall, we show that professionally-applied cosmetics produce a larger effect than self-applied cosmetics, an important theoretical consideration for the field. However, the effect of individual differences in facial appearance is ultimately more important in perceptions of attractiveness.

  6. Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats.

    Science.gov (United States)

    Agarwal, Renu; Gupta, S K; Agarwal, Puneet; Srivastava, Sushma

    2013-10-01

    Aqueous extract of C. longa when administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade and aqueous humor (AH) protein level compared to vehicle treated group. Although, prednisolone group showed significantly lower clinical grade, histopathological grades and AH protein levels compared to C. longa group, TNF-alpha levels did not differ significantly. Moreover, when the aqueous extract was administered starting from 3 days before induction of uveitis, the mean clinical and histopathological grade as well as AH protein and TNF-alpha levels were comparable to C. longa group when treatment was administered 4 h after induction of uveitis. It is concluded that topically applied standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity.

  7. Chemical ultraviolet absorbers topically applied in a skin barrier mimetic formulation remain in the outer stratum corneum of porcine skin.

    Science.gov (United States)

    Haque, T; Crowther, J M; Lane, M E; Moore, D J

    2016-08-20

    The objective of the present study was to evaluate the fate of three chemical sunscreens, isoamyl p-methoxycinnamate (IPMC), diethylamino hydroxybenzoyl hexyl benzoate (DHHB), and bis-ethylhexylphenol methoxyphenyl triazine (BEMT), topically applied to mammalian skin from a skin barrier mimetic oil-in-water formulation. High Performance Liquid Chromatography (HPLC) methods were developed for the analysis of each molecule and validated. Franz cell permeation studies were conducted following application of finite doses of the formulations to excised porcine skin. A vehicle formulation containing no sunscreens was evaluated as a control. Permeation studies were conducted for 12h after which full mass balance studies were carried out. Analysis of individual UV sunscreens was achieved with HPLC following application of the formulation to the skin with no interference from the vehicle components. No skin permeation of any of the chemical sunscreens was evident after 12h. While sunscreens were detected in up to 12 tape strips taken from the SC, 87% or more of the applied doses recovered in the first 5 tape strips. When corrected for the amount of protein removed per tape strip this corresponded to a penetration depth in porcine stratum corneum of ∼1.7μm. Mass balance studies indicated total recovery values were within accepted guidelines for cosmetic formulations. Overall, only superficial penetration into the SC was observed for each compound. These findings are consistent with the physicochemical properties of the selected UV absorbing molecules and their formulation into an ordered biomimetic barrier formulation thus support their intended use in topical consumer formulations designed to protect from UV exposure. To our knowledge this is the first report of depth profiling of chemical sunscreens in the SC that combines tape stripping and protein determination following in vitro Franz cell studies. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. The use of applied software for the professional training of students studying humanities

    Science.gov (United States)

    Sadchikova, A. S.; Rodin, M. M.

    2017-01-01

    Research practice is an integral part of humanities students' training process. In this regard the training process is to include modern information techniques of the training process of students studying humanities. This paper examines the most popular applied software products used for data processing in social science. For testing purposes we selected the most commonly preferred professional packages: MS Excel, IBM SPSS Statistics, STATISTICA, STADIA. Moreover the article contains testing results of a specialized software Prikladnoy Sotsiolog that is applicable for the preparation stage of the research. The specialised software were tested during one term in groups of students studying humanities.

  9. HydroShare: Applying professional software engineering to a new NSF-funded large software project

    Science.gov (United States)

    Idaszak, R.; Tarboton, D. G.; Ames, D.; Saleem Arrigo, J. A.; Band, L. E.; Bedig, A.; Castronova, A. M.; Christopherson, L.; Coposky, J.; Couch, A.; Dash, P.; Gan, T.; Goodall, J.; Gustafson, K.; Heard, J.; Hooper, R. P.; Horsburgh, J. S.; Jackson, S.; Johnson, H.; Maidment, D. R.; Mbewe, P.; Merwade, V.; Miles, B.; Reeder, S.; Russell, T.; Song, C.; Taylor, A.; Thakur, S.; Valentine, D. W.; Whiteaker, T. L.

    2013-12-01

    HydroShare is an online, collaborative system being developed for sharing hydrologic data and models as part of the NSF's Software Infrastructure for Sustained Innovation (SI2) program (NSF collaborative award numbers 1148453 and 1148090). HydroShare involves a large software development effort requiring cooperative research and distributed software development between domain scientists, professional software engineers (here 'professional' denotes previous commercial experience in the application of modern software engineering), and university software developers. HydroShare expands upon the data sharing capabilities of the Hydrologic Information System of the Consortium of Universities for the Advancement of Hydrologic Sciences, Inc. (CUAHSI) by broadening the classes of data accommodated, expanding capability to include the sharing of models and model components, and taking advantage of emerging social media functionality to enhance information about and collaboration around hydrologic data and models. With a goal of enabling better science concomitant with improved sustainable software practices, we will describe our approach, experiences, and lessons learned thus-far in applying professional software engineering to a large NSF-funded software project from the project's onset.

  10. APPLYING PROFESSIONALLY ORIENTED PROBLEMS OF MATHEMATICAL MODELING IN TEACHING STUDENTS OF ENGINEERING DEPARTMENTS

    Directory of Open Access Journals (Sweden)

    Natal’ya Yur’evna Gorbunova

    2017-06-01

    Full Text Available We described several aspects of organizing student research work, as well as solving a number of mathematical modeling problems: professionally-oriented, multi-stage, etc. We underlined the importance of their economic content. Samples of using such problems in teaching Mathematics at agricultural university were given. Several questions connected with information material selection and peculiarities of research problems application were described. Purpose. The author aims to show the possibility and necessity of using professionally-oriented problems of mathematical modeling in teaching Mathematics at agricultural university. The subject of analysis is including such problems into educational process. Methodology. The main research method is dialectical method of obtaining knowledge of finding approaches to selection, writing and using mathematical modeling and professionally-oriented problems in educational process; the methodology is study of these methods of obtaining knowledge. Results. As a result of analysis of literature, students opinions, observation of students work, and taking into account personal teaching experience, it is possible to make conclusion about importance of using mathematical modeling problems, as it helps to systemize theoretical knowledge, apply it to practice, raise students study motivation in engineering sphere. Practical implications. Results of the research can be of interest for teachers of Mathematics in preparing Bachelor and Master students of engineering departments of agricultural university both for theoretical research and for modernization of study courses.

  11. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin.

    Science.gov (United States)

    Houston, David M J; Bugert, Joachim; Denyer, Stephen P; Heard, Charles M

    2017-03-01

    Coadministered pomegranate rind extract (PRE) and zinc (II) produces a potent virucidal activity against Herpes simplex virus (HSV); however, HSV infections are also associated with localised inflammation and pain. Here, the objective was to determine the anti-inflammatory activity and relative depth penetration of PRE, total pomegranate tannins (TPT) and zinc (II) in skin, ex vivo. PRE, TPT and ZnSO 4 were dosed onto freshly excised ex vivo porcine skin mounted in Franz diffusion cells and analysed for COX-2, as a marker for modulation of the arachidonic acid inflammation pathway, by Western blotting and immunohistochemistry. Tape stripping was carried out to construct relative depth profiles. Topical application of PRE to ex vivo skin downregulated expression of COX-2, which was significant after just 6h, and maintained for up to 24h. This was achieved with intact stratum corneum, proving that punicalagin penetrated skin, further supported by the depth profiling data. When PRE and ZnSO 4 were applied together, statistically equal downregulation of COX-2 was observed when compared to the application of PRE alone; no effect followed the application of ZnSO 4 alone. TPT downregulated COX-2 less than PRE, indicating that tannins alone may not be entirely responsible for the anti-inflammatory activity of PRE. Punicalagin was found throughout the skin, in particular the lower regions, indicating appendageal delivery as a significant route to the viable epidermis. Topical application of TPT and PRE had significant anti-inflammatory effects in ex vivo skin, confirming that PRE penetrates the skin and modulates COX-2 regulation in the viable epidermis. Pomegranates have potential as a novel approach in ameliorating the inflammation and pain associated with a range of skin conditions, including cold sores and herpetic stromal keratitis. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Imaging bio-distribution of a topically applied dermatological cream on minipig skin using fluorescence lifetime imaging microscopy (Conference Presentation)

    Science.gov (United States)

    Alex, Aneesh; Chaney, Eric J.; Criley, Jennifer M.; Spillman, Darold R.; Hutchison, Phaedra B.; Li, Joanne; Marjanovic, Marina; Frey, Steve; Cook, Steven; Boppart, Stephen A.; Arp, Zane A.

    2017-02-01

    Currently there is a lack of in vivo techniques to evaluate the spatial bio-distribution of dermal drugs over time without the need to take multiple serial biopsies. To address this gap, we investigated the use of multi-photon optical imaging methods to non-invasively track drug distribution on miniature pig (Species: Sus scrofa, Strain: Göttingen) skin in vivo. Minipig skin is the standard comparative research model to human skin, and is anatomically and functionally similar. We employed fluorescence lifetime imaging microscopy (FLIM) to visualize the spatial distribution and residency time of a topically applied experimental dermatological cream. This was made possible by the endogenous fluorescent optical properties of the experimental drug (fluorescence lifetime > 3000 ps). Two different drug formulations were applied on 2 minipigs for 7 consecutive days, with the control creams applied on the contralateral side, followed by 7 days of post-application monitoring using a multi-modal optical imaging system (MPTflex-CARS, JenLab, Germany). FLIM images were obtained from the treated regions 24 hr post-application from day 1 to day 14 that allowed visualization of cellular and sub-cellular features associated with different dermal layers non-invasively to a depth of 200 µm. Five punch biopsies per animal were obtained from the corresponding treated regions between days 8 and 14 for bioanalytical analysis and comparison with results obtained using FLIM. In conclusion, utilization of non-invasive optical biopsy methods for dermal drug evaluation can provide true longitudinal monitoring of drug spatial distribution, remove sampling limitations, and be more time-efficient compared to traditional methods.

  13. The factorial structure of professionally-applied physical fitness of students of railway specialties

    Directory of Open Access Journals (Sweden)

    Anzhelika Yefremova

    2017-02-01

    Full Text Available Purpose: to define the factorial structure of professionally-applied physical fitness of students – future electrical engineers of railway transport. Material & Methods: analysis and synthesis of references, questioning, anthropometry, testing, functional tests, and methods of mathematical statistics (the factorial analysis with application of the computer program "SPSS 17.0". 50 students (young men of Ukrainian state railway university participated in the research. Results: the ratio of means of physical culture which are expedient to use for the optimization of professionally-applied physical training of future specialists of the railway branch is defined. Conclusions: the factorial analysis allowed to distribute means of physical education as follows: physical exercises which are directed to the increase in physical working capacity and overall physical fitness – about 40%; exercises on the development of power qualities – 25%; exercises on the development of high-speed and power endurance – 15%; means which are allocated for the improvement of functions of attention and kinetic sensitivity – 10%; exercises which are directed to the increase in special working capacity – 10%.

  14. Towson University's Professional Science Master's Program in Applied Physics: The first 5 years

    Science.gov (United States)

    Kolagani, Rajeswari

    It is a well-established fact that the scientific knowledge and skills acquired in the process of obtaining a degree in physics meet the needs of a variety of positions in multiple science and technology sectors. However, in addition to scientific competence, challenging careers often call for skills in advanced communication, leadership and team functions. The professional science master's degree, which has been nick-named as the `Science MBA', aims at providing science graduates an edge both in terms of employability and earning levels by imparting such skills. Our Professional Science Master's Program in Applied Physics is designed to develop these `plus' skills through multiple avenues. In addition to advanced courses in Applied Physics, the curriculum includes graduate courses in project management, business and technical writing, together with research and internship components. I will discuss our experience and lessons learned over the 5 years since the inception of the program in 2010. The author acknowledges support from the Elkins Professorship of the University System of Maryland.

  15. Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction.

    Science.gov (United States)

    Nagano, F; Kaneko, T; Yoshinaga, Y; Ukai, T; Kuramoto, A; Nakatsu, S; Oshino, K; Ichimura, I; Hara, Y

    2013-08-01

    Periodontitis is generally accepted to relate to gram-negative bacteria, and the host defense system influences its onset and progression. However, little is known about the relation between gram-positive bacteria and periodontitis. In this study, we topically applied gram-positive and gram-negative bacterial suspensions to the gingival sulcus in rats after immunization, and then histopathologically examined their influence on periodontal destruction. Rats previously immunized with heat-treated and sonicated Staphylococcus aureus or Aggregatibacter actinomycetemcomitans were used as immunized groups. The non-immunized group received only sterile phosphate-buffered saline. In each animal, S. aureus or A. actinomycetemcomitans suspension was applied topically to the palatal gingival sulcus of first molars every 24 h for 10 d. Blood samples were collected and the serum level of anti-S. aureus or anti-A. actinomycetemcomitans immunoglobulin G (IgG) antibodies was determined by enzyme-linked immunosorbent assay. The first molar regions were resected and observed histopathologically. Osteoclasts were stained with tartrate-resistant acid phosphatase (TRAP). The formation of immune complexes was confirmed by immunohistological staining of C1qB. Serum levels of anti-S. aureus and anti-A. actinomycetemcomitans IgG antibodies in the immunized groups were significantly higher than those in the non-immunized groups were. The loss of attachment, increase in apical migration of the junctional epithelium, and decreases in alveolar bone level and number of TRAP-positive multinuclear cells in each immunized group were significantly greater than in each non-immunized group. The presence of C1qB was observed in the junctional epithelium and adjacent connective tissue in the immunized groups. Heat-treated and sonicated S. aureus and A. actinomycetemcomitans induced attachment loss in rats immunized with their suspensions. Our results suggest that not only gram-negative but also gram

  16. Mutual medication in capuchin monkeys - Social anointing improves coverage of topically applied anti-parasite medicines.

    Science.gov (United States)

    Bowler, Mark; Messer, Emily J E; Claidière, Nicolas; Whiten, Andrew

    2015-10-12

    Wild and captive capuchin monkeys will anoint themselves with a range of strong smelling substances including millipedes, ants, limes and onions. Hypotheses for the function of the behaviour range from medicinal to social. However, capuchin monkeys may anoint in contact with other individuals, as well as individually. The function of social anointing has also been explained as either medicinal or to enhance social bonding. By manipulating the abundance of an anointing resource given to two groups of tufted capuchins, we tested predictions derived from the main hypotheses for the functions of anointing and in particular, social anointing. Monkeys engaged in individual and social anointing in similar proportions when resources were rare or common, and monkeys holding resources continued to join anointing groups, indicating that social anointing has functions beyond that of gaining access to resources. The distribution of individual and social anointing actions on the monkeys' bodies supports a medicinal function for both individual and social anointing, that requires no additional social bonding hypotheses. Individual anointing targets hard-to-see body parts that are harder to groom, whilst social anointing targets hard-to-reach body parts. Social anointing in capuchins is a form of mutual medication that improves coverage of topically applied anti-parasite medicines.

  17. Mutual medication in capuchin monkeys – Social anointing improves coverage of topically applied anti-parasite medicines

    Science.gov (United States)

    Bowler, Mark; Messer, Emily J. E.; Claidière, Nicolas; Whiten, Andrew

    2015-01-01

    Wild and captive capuchin monkeys will anoint themselves with a range of strong smelling substances including millipedes, ants, limes and onions. Hypotheses for the function of the behaviour range from medicinal to social. However, capuchin monkeys may anoint in contact with other individuals, as well as individually. The function of social anointing has also been explained as either medicinal or to enhance social bonding. By manipulating the abundance of an anointing resource given to two groups of tufted capuchins, we tested predictions derived from the main hypotheses for the functions of anointing and in particular, social anointing. Monkeys engaged in individual and social anointing in similar proportions when resources were rare or common, and monkeys holding resources continued to join anointing groups, indicating that social anointing has functions beyond that of gaining access to resources. The distribution of individual and social anointing actions on the monkeys’ bodies supports a medicinal function for both individual and social anointing, that requires no additional social bonding hypotheses. Individual anointing targets hard-to-see body parts that are harder to groom, whilst social anointing targets hard-to-reach body parts. Social anointing in capuchins is a form of mutual medication that improves coverage of topically applied anti-parasite medicines. PMID:26456539

  18. Effects of a topically applied wound ointment on epidermal wound healing studied by in vivo fluorescence laser scanning microscopy analysis

    Science.gov (United States)

    Lange-Asschenfeldt, Bernhard; Alborova, Alena; Krüger-Corcoran, Daniela; Patzelt, Alexa; Richter, Heike; Sterry, Wolfram; Kramer, Axel; Stockfleth, Eggert; Lademann, Jürgen

    2009-09-01

    Epidermal wound healing is a complex and dynamic regenerative process necessary to reestablish skin integrity. Fluorescence confocal laser scanning microscopy (FLSM) is a noninvasive imaging technique that has previously been used for evaluation of inflammatory and neoplastic skin disorders in vivo and at high resolution. We employed FLSM to investigate the evolution of epidermal wound healing noninvasively over time and in vivo. Two suction blisters were induced on the volar forearms of the study participants, followed by removal of the epidermis. To study the impact of wound ointment on the process of reepithelization, test sites were divided into two groups, of which one test site was left untreated as a negative control. FLSM was used for serial/consecutive evaluations up to 8 days. FLSM was able to visualize the development of thin keratinocyte layers developing near the wound edge and around hair follicles until the entire epidermis has been reestablished. Wounds treated with the wound ointment were found to heal significantly faster than untreated wounds. This technique allows monitoring of the kinetics of wound healing noninvasively and over time, while offering new insights into the potential effects of topically applied drugs on the process of tissue repair.

  19. Penetration of topically applied nanocarriers into the hair follicles of dog and rat dorsal skin and porcine ear skin.

    Science.gov (United States)

    Knorr, Fanny; Patzelt, Alexa; Darvin, Maxim E; Lehr, Claus-Michael; Schäfer, Ulrich; Gruber, Achim D; Ostrowski, Anja; Lademann, Jürgen

    2016-08-01

    In humans, topically applied nanocarriers penetrate effectively into the hair follicles where they can be exploited for the localized and targeted treatment of skin disorders. The objective of the present study was to examine the applicability of particle-based systems for follicular drug delivery in companion animals and livestock, which have a large follicular reservoir. Skin samples from 10 beagle dogs, 14 Wistar rats and four ears from freshly slaughtered cross-bred pigs were used. Fluoresceinamine labelled poly (L-lactide-co-glycolide) nanocarriers (256 or 430 nm) were applied on the different skin samples. After penetration, skin biopsies were removed and cryohistological cross sections prepared and investigated with regard to the follicular penetration depths (in μm ± standard deviation) of the nanocarriers using confocal laser scanning microscopy. In canine, rat and porcine hair follicles, the smaller nanoparticles were detected at mean follicular penetration depths of 630.16 ± 135.75 μm, 253.55 ± 47.36 μm and 653.40 ± 94.71 μm, respectively. The larger particles were observed at average follicular depths of 604.79 ± 132.42 μm; 262.87 ± 55.25 μm and 786.81 ± 121.73 μm, respectively, in canine, rat and porcine hair follicles. Statistically significant differences (P porcine skin samples. The mean follicular penetration depths of the differently sized nanocarriers were mostly significantly different between the different species, which might be due to different species-specific follicular dimensions. This issue needs to be addressed specifically in further studies. © 2016 ESVD and ACVD.

  20. Professionally significant psychophysiological qualities of information logical group of specialties at implementation of the experimental program of professionally applied physical training of students

    Directory of Open Access Journals (Sweden)

    Ostapenko Y.O.

    2014-03-01

    Full Text Available Purpose: to improve vocational and applied physical training of students of economics. Material: the pedagogical study involved 72 male students (aged 19-20 years. Results: job study was conducted. Defined professionally significant neurobehavioral performance of students of information logical group. Matched professionally applied exercises for their development. The results showed that in the process of purposeful muscle activity improved mechanisms of regulation of neural processes, adaptive changes occur that affect the temporal parameters of sensorimotor motor responses. A comparative analysis of the psychophysiological indicators of students of the control and experimental groups was done. Conclusions: it was found that matched professionally applied exercises positively affect the development of psycho-physiological qualities of students information and logical group of specialties.

  1. Ciclopirox Topical

    Science.gov (United States)

    ... treatment. Use the applicator brush attached to the bottle cap to apply ciclopirox topical solution evenly to all ... you can reach these areas. Wipe off the bottle cap and neck and replace the cap tightly on ...

  2. Estradiol Topical

    Science.gov (United States)

    ... a medication that is applied topically to the vagina. Estradiol is in a class of medications called ... swelling, redness, burning, irritation, or itching of the vagina vaginal discharge Some side effects can be serious. ...

  3. Noospheric vector of management applied to the system of higher professional education

    Directory of Open Access Journals (Sweden)

    Yulia A. Mishina

    2017-01-01

    Full Text Available The aim of the research is to substantiate the necessity, expediency of the wide use of the noospheric management approaches, and technologies applied to the system of higher professional education in modern conditions. The materials and methods. Information base of the research is formed, based on education laws in Ukraine, Russia and the Donetsk People’s Republic, educational standards of higher professional education, as well as publications of scientists on the subject matter under study. In the given research it was used such methods: textological, analysis, generalization and modeling. The results. In the research, it is comprehensively examined the concept of noosphere, analyzed the modern theories and concepts of its development in relation to the development of society, an integral part of which is the system of education. It is indicated that there is the relationship between the noosphere and management in general, and with modern system of education, in particular. The concept of noospheric education is introduced and studied its impact on holistic  development of personality. The comparative characteristic of the structure and levels of the educational system of Ukraine, the Russian Federation and the Donetsk People’s Republic is performed; the types of educational institutions of the abovementioned states are compared. The structure of educational institution of higher professional education is proposed as a socio-economic system, managed from the perspective of the concept of noospheric education. The factors of competitiveness of educational institution of the higher school from the point of view of noospheric management are considered. Special attention is given to the internal factor of competitiveness of educational institutions, such as the quality of student life, because this position, particularly from the point of view of noospheric management, has a significant influence on the rating among consumers. The

  4. Approach towards developing a novel procedure to selectively quantify topically applied substances in the hair follicles of the model tissue porcine ear skin.

    Science.gov (United States)

    Knorr, Fanny; Patzelt, Alexa; Richter, Heike; Schanzer, Sabine; Sterry, Wolfram; Lademann, Juergen

    2013-06-01

    Hair follicles represent reservoirs for localized drug therapy and transport pathways for systemic drug delivery. This study describes an approach towards developing a novel procedure for quantifying topically applied substances located in the hair follicles of porcine ear skin, a model for human in vivo skin, using a fluorescent dye. Approximately 5% of the topically applied dye was recovered from the hair follicles, which is in accordance with a previous study. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Using Insights from Applied Moral Psychology to Promote Ethical Behavior Among Engineering Students and Professional Engineers.

    Science.gov (United States)

    Gelfand, Scott D

    2016-10-01

    In this essay I discuss a novel engineering ethics class that has the potential to significantly decrease the likelihood that students (and professionals) will inadvertently or unintentionally act unethically in the future. This class is different from standard engineering ethics classes in that it focuses on the issue of why people act unethically and how students (and professionals) can avoid a variety of hurdles to ethical behavior. I do not deny that it is important for students to develop cogent moral reasoning and ethical decision-making as taught in traditional college-level ethics classes, but as an educator, I aim to help students apply moral reasoning in specific, real-life situations so they are able to make ethical decisions and act ethically in their academic careers and after they graduate. Research in moral psychology provides evidence that many seemingly irrelevant situational factors affect the moral judgment of most moral agents and frequently lead agents to unintentionally or inadvertently act wrongly. I argue that, in addition to teaching college students moral reasoning and ethical decision-making, it is important to: 1. Teach students about psychological and situational factors that affect people's ethical judgments/behaviors in the sometimes stressful, emotion-laden environment of the workplace; 2. Guide students to engage in critical reflection about the sorts of situations they personally might find ethically challenging before they encounter those situations; and 3. Provide students with strategies to help them avoid future unethical behavior when they encounter these situations in school and in the workplace.

  6. Organization and content efficiency substantiation of a strengthened professional and applied physical training course for railway higher educational institution students

    Directory of Open Access Journals (Sweden)

    Anzhelika Yefremova

    2017-08-01

    Full Text Available Purpose: to experimentally substantiate the effectiveness of the application of the experimental program for physical education with an intensified course of professional-applied physical training (PAPT for students of I–II courses of railway specialties. Material & Methods: analysis and generalization of literary sources, pedagogical experiment, pedagogical testing, physiological and psycho-physiological methods, methods of mathematical statistics. Result: obtained data after the introduction of the experimental program on physical education with an intensified course of professional-applied physical training, students of railway universities. Conclusion: analysis and generalization of the literature sources found the absence of a scientifically based program of PAPT for students of higher education institutions of the railway profile. The introduction in the educational process of physical education of the experimental program on physical education with the strengthened course of the PAPT showed an increase in the level of physical, professionally applied physical and psycho-physiological readiness of students.

  7. Using NASA Space Imaging to Teach Earth and Sun Topics in Professional Development Courses for In-Service Teachers

    Science.gov (United States)

    Verner, E.; Bruhweiler, F. C.; Long, T.; Edwards, S.; Ofman, L.; Brosius, J. W.; Holman, G.; St Cyr, O. C.; Krotkov, N. A.; Fatoyinbo Agueh, T.

    2012-12-01

    several PD courses using NASA imaging technology. It includes various ways to study selected topics in physics and astronomy. We use NASA Images to develop lesson plans and EPO materials for PreK-8 grades. Topics are Space based and they vary from measurements, magnetism on Earth to that for our Sun. In addition we cover topics on ecosystem structure, biomass and water on Earth. Hands-on experiments, computer simulations, analysis of real-time NASA data, and vigorous seminar discussions are blended in an inquiry-driven curriculum to instill confident understanding of basic physical science and modern, effective methods for teaching it. Course also demonstrates ways how scientific thinking and hands-on activities could be implemented in the classroom. This course is designed to provide the non-science student a confident understanding of basic physical science and modern, effective methods for teaching it. Most of topics were selected using National Science Standards and National Mathematics Standards to be addressed in grades PreK-8. The course focuses on helping in several areas of teaching: 1) Build knowledge of scientific concepts and processes; 2) Understand the measurable attributes of objects and the units and methods of measurements; 3) Conducting data analysis (collecting, organizing, presenting scientific data, and to predict the result); 4) Use hands-on approaches to teach science; 5) Be familiar with Internet science teaching resources. Here we share our experiences and challenges we faced teaching this course.

  8. Methods of the professional-applied physical preparation of students of higher educational establishments of economic type

    Directory of Open Access Journals (Sweden)

    Maliar E.I.

    2010-11-01

    Full Text Available Is considered the directions of professionally-applied physical preparation of students with the prevailing use of facilities of football. Are presented the methods of professionally-applied physical preparation of students. It is indicated that application of method of the circular training is rendered by an assistance development of discipline, honesty, honesty, rational use of time. Underline, that in teaching it is necessary to provide a short cut to mastering of the planned knowledge, abilities and skills, improvement of physical qualities.

  9. 21 CFR 310.530 - Topically applied hormone-containing drug products for over-the-counter (OTC) human use.

    Science.gov (United States)

    2010-04-01

    ... substance formed in some organ of the body, such as the adrenal glands or the pituitary, and carried to... marketed for topical use as hormone creams. However, there is a lack of adequate data to establish... is that the product will have a therapeutic or some other physiological effect on the body. Therefore...

  10. Using blended and guided technologies in a university course for scientist-practitioners: teaching applied behaviour analysis to autism professionals.

    Science.gov (United States)

    Roll-Pettersson, Lise; Ala'i-Rosales, Shahla

    2009-06-01

    Although the incidence of autism spectrum disorders is increasing worldwide, there is a shortage of professionals trained to provide effective interventions. The article describes an advanced university course in Applied Behaviour Analysis (ABA) and autism tailored to meet the needs of Swedish professionals from multiple disciplines. The course implemented both blended-learning technologies (web, telecommunication, and in vivo) and guided-design (problem-solving) exercises to promote the scientist-practitioner model. Overall, students advanced their skills related to identifying extant scientific literature, choosing appropriate single-subject design evaluation methods, and critically analysing the effects of attempted interventions. Students rated the course as having high social validity and predicted the course content would positively affect their professional practice. The relevance of the course and future directions are discussed in the context of meeting the global need for effective autism intervention professionals.

  11. Efficacy of orally administered fluralaner (Bravecto™) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs.

    Science.gov (United States)

    Fourie, Josephus J; Liebenberg, Julian E; Horak, Ivan G; Taenzler, Janina; Heckeroth, Anja R; Frénais, Regis

    2015-03-28

    This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs. Sixteen dogs, all diagnosed with generalized demodectic mange, were randomly allocated to two equal groups. Bravecto™ chewable tablets were administered once orally at a minimum dose of 25 mg fluralaner/kg body weight to one group of dogs, while the second group was treated topically on three occasions at 28-day intervals with Advocate® at a minimum dose of 10 mg imidacloprid/kg body weight and 2.5 mg moxidectin/kg body weight. Mites were counted in skin scrapings and demodectic lesions were evaluated on each dog before treatment and at 28-day intervals thereafter over a 12 week study period. Deep skin scrapings (~4 cm(2)) were made from the same five sites on each dog at each subsequent examination. After single oral administration of Bravecto™ chewable tablets, mite numbers in skin scrapings were reduced by 99.8% on Day 28 and by 100% on Days 56 and 84. Mite numbers in the dogs treated topically on three occasions at 28-day intervals with Advocate® were reduced by 98.0% on Day 28, by 96.5% on Day 56 and by 94.7% on Day 84. Statistically significantly (P ≤ 0.05) fewer mites were found on Days 56 and 84 on the Bravecto™ treated dogs compared to Advocate® treated dogs. A marked decrease was observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravecto™ and in the occurrence of erythematous patches in the dogs treated with Advocate®. With the exception of one dog in each treated group, all dogs exhibited hair regrowth ≥ 90% at the end of the study in comparison with their hair-coat at study start. Single oral administration of Bravecto™ chewable tablets is highly effective against generalized demodicosis, with no mites detectable at

  12. Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers.

    Science.gov (United States)

    Lodén, M

    2014-09-01

    Virtually everyone in Europe will use at least one cosmetic product every day. The extensive use of cosmetics and results from measurements of quality of life in patients with skin diseases demonstrate the importance of a healthy skin. The skin is not only a barrier against desiccation and intrusion of harmful materials, but also an organ of social communication, where dry, scaly, rough stratum corneum is unappealing to touch, inducing anxiety and depression. Knowledge about the skin biochemistry and the use of noninvasive instruments facilitate the development of topical products and quantification of their effects. The presentation of the products and mode of action determine the regulatory demands and the approval process, as they can fall into different regulatory entities, such as cosmetics, medicinal products, medical devices and as other chemical products. The majority of the topical products on the market are regulated as cosmetics. For example, facial skin care and daily moisturizing routines are frequently used. However, despite visible relief of dryness symptoms, some products are reported to result in deterioration of the skin barrier function. New clinical outcomes show important clinical differences between formulations and the relapse of eczema. In a worst case scenario, treatment with a moisturizing cream may increase the risks of eczema and asthma. In the present overview, product presentations and mode of actions are reflected against the regulatory demands in Europe. The regulations are continuously revisited and new guidelines are being implemented, such as the new cosmetic regulation with advice on testing and responsible marketing. © 2014 The Author BJD © 2014 British Association of Dermatologists.

  13. Health professionals and the meaning they apply to women‟s remaining in violent conjugal relationships

    Directory of Open Access Journals (Sweden)

    Nadirlene Pereira Gomes

    2013-06-01

    Full Text Available The authors aim to investigate the meanings attributed by health professionals working in the Family Health Strategy to women‟s remaining in violent conjugal relationships. The research is based in the method of Grounded Theory. Interviews were held between May and August 2012 with 52 professionals who work in Family Health in a city in the Brazilian state of Santa Catarina. It is indicated that violence is related to the threats made, to the partner‟s involvement in drug trafficking, to economic and emotional dependence, to the valuing of marriage, to the belief in female submission, and to shame. The professionals indicate the need for strategies in defense of a life free from violence for women: psycho-social support; educational activities regarding the social construction of gender; and articulation of policies based on intersectoriality.

  14. Managing the professional nurse. Part II. Applying management theory to the challenges.

    Science.gov (United States)

    McClure, M L

    1984-03-01

    In Part I of this article, the author reviewed the ideas of some of the major administrative thinkers over the past 30 years. Having set the stage with an overview of current thinking in the general area of management theory, the author here examines some of the specific challenges involved in managing the professional nurse. Often, these problems are unique and the management theorists offer only limited help. In other instances, management theory is directly relevant. The author addresses the following four broad categories that are unique to the profession of nursing: nursing as a female profession, professionalism and the lack of it, stress and burnout, and expectancy congruence.

  15. A Mixed-Methods Analysis in Assessing Students' Professional Development by Applying an Assessment for Learning Approach.

    Science.gov (United States)

    Peeters, Michael J; Vaidya, Varun A

    2016-06-25

    Objective. To describe an approach for assessing the Accreditation Council for Pharmacy Education's (ACPE) doctor of pharmacy (PharmD) Standard 4.4, which focuses on students' professional development. Methods. This investigation used mixed methods with triangulation of qualitative and quantitative data to assess professional development. Qualitative data came from an electronic developmental portfolio of professionalism and ethics, completed by PharmD students during their didactic studies. Quantitative confirmation came from the Defining Issues Test (DIT)-an assessment of pharmacists' professional development. Results. Qualitatively, students' development reflections described growth through this course series. Quantitatively, the 2015 PharmD class's DIT N2-scores illustrated positive development overall; the lower 50% had a large initial improvement compared to the upper 50%. Subsequently, the 2016 PharmD class confirmed these average initial improvements of students and also showed further substantial development among students thereafter. Conclusion. Applying an assessment for learning approach, triangulation of qualitative and quantitative assessments confirmed that PharmD students developed professionally during this course series.

  16. 34 CFR 263.3 - What definitions apply to the Professional Development program?

    Science.gov (United States)

    2010-07-01

    ... post-baccalaureate degree awarded by an institution of higher education beyond the undergraduate level... an organized Indian group that received a grant under the Indian Education Act of 1988 as it was in... trained under the Professional Development program. Payback means work-related service or cash...

  17. Histamine Applied Topically to the Nasal Mucosa Increases the Transmucosal Nitrous Oxide Exchange for the Middle Ear.

    Science.gov (United States)

    Teixeira, Miriam S; Alper, Cuneyt M; Martin, Brian S; Cetin, Selma; El-Wagaa, Jenna A; Doyle, William J

    2017-04-01

    Determine if the middle ear transmucosal nitrous oxide (N2O) exchange rate is affected by nasal inflammation caused by topical application of histamine. In a randomized, double-blind, crossover study, 20 adults were challenged intranasally with histamine (5 mg) and placebo on separate occasions. At each session, the subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and 100% O2 for 10 minutes. Throughout, heart rate, blood pressure, and blood O2 saturation were monitored, and bilateral middle ear pressure was recorded by tympanometry every minute. The primary outcome measure was the slope of the middle ear pressure-time function for the 50% N2O:50% O2 breathing period, which is a measure of the transmucosal N2O exchange-constant. The effects of challenge substance, session, and period on the measured vital signs and of treatment, session, ear disease history, and test ear on the pressure-time slopes were evaluated using repeated measures ANOVAs. The post-challenge total symptom score and the slope of the middle ear pressure-time function were greater after histamine when compared to placebo challenge. Of the signs, only heart rate was affected, responding to challenge substance and study period. The transmucosal N2O exchange rate for the middle ear is increased during inflammation caused by nasal histamine exposure.

  18. The impact of topically applied preservation solutions on the respiratory epithelium of tracheal grafts submitted to cold ischemia: functional and morphological analysis

    Directory of Open Access Journals (Sweden)

    Artur Eugênio de Azevedo-Pereira

    2013-05-01

    Full Text Available OBJECTIVE: Advances in graft reepithelialization and revascularization have renewed interest in airway transplantation. This study aims to determine whether topically applied preservation solutions can ameliorate ischemic injury to tracheal grafts. We analyzed 1 the effects of cold ischemia on the mucociliary clearance of tracheal grafts and 2 the impact of topically applied preservation solutions on the effects of cold ischemia on mucociliary clearance. METHOD: Tracheal segments (n=217 from 109 male Wistar rats were harvested, submerged in low-potassium-dextran-glucose, histidine-tryptophan-ketoglutarate, or saline solution (saline group, and stored at 4°C for 6, 10, 16, or 24 hours. A control group (not submerged was analyzed immediately after harvesting. In situ mucociliary transport and ciliary beating frequency were measured using a stroboscope. Epithelial integrity, cellular infiltration, and mucus storage were quantified by light microscopy and image analysis software, along with transmission electron microscopy. RESULTS: 1 The effects of cold ischemia: in situ mucociliary transport and ciliary beating frequency were greater in the control group than after cold ischemia. Microscopic analysis results were similar between groups. 2 The effects of preservation solutions: there was no difference between the low-potassium-dextran-glucose, histidine-tryptophan-ketoglutarate, and saline groups in functional or light microscopy analysis. The saline group presented stronger signs of ischemic injury with transmission electron microscopy. CONCLUSIONS: Cold ischemia diminished the mucociliary clearance of the tracheal respiratory epithelium. Topically applied preservation solutions did not ameliorate the injury caused by cold ischemia to the tracheal respiratory epithelium.

  19. Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy

    Science.gov (United States)

    Tar, Moses; Cabrales, Pedro; Mahantesh, Navarti; Adler, Brandon; Nacharaju, Parimala; Friedman, Adam; Friedman, Joel; Davies, Kelvin P.

    2014-01-01

    Introduction Patients undergoing radical prostatectomy (RP) suffer from erectile dysfunction (ED) refractory to PDE5 inhibitors, which act downstream of CN-mediated release of nitric oxide (NO). Direct delivery of NO to the penis could potentially circumvent this limitation. Aim To determine if topically applied NO-releasing nanoparticles (NO-np) can elicit erections in a rat model of RP and demonstrate that the mechanism is through increased blood flow. Methods 26 Sprague–Dawley rats underwent bilateral transection of the CN. One week later NO-np were applied topically to the penile shaft in DMSO-gel (10 animals) or coconut oil (6 animals). Control animals were treated with empty-np. Erectile function was determined through the intracorporal pressure/blood pressure ratio (ICP/BP). The effect of the NO-np on blood flow was determined using a hamster dorsal window chamber. Main Outcome Measures Animals were investigated for spontaneous erections, onset and duration of erectile response and basal ICP/BP ratio. Microcirculatory blood-flow was determined through arteriolar and venular diameter and blood flow. Results Eight of ten animals treated with NO-np suspended in DMSO-gel had significant increases in basal ICP/BP, and six out of these ten animals demonstrated spontaneous erections of approximately one minute duration. Onset of spontaneous erections ranged from 5–37 minutes and occurred for at least 45 minutes. Similar results were observed with NO-np applied in coconut oil. No erectile response was observed in control animal models treated with empty-np. The hamster dorsal window chamber demonstrated NO-np applied as a suspension in coconut oil caused a significant increase in the microcirculatory blood flow, sustained over 90 minutes. Conclusions Topically applied NO-np induced spontaneous erections and increased basal ICP in an animal model of RP. These effects are most likely due to increased microcirculatory blood flow. These characteristics suggest that

  20. The impact of staff training on special educational needs professionals' attitudes toward and understanding of applied behavior analysis.

    Science.gov (United States)

    Smyth, Sinéad; Reading, Benjamin E; McDowell, Claire

    2017-01-01

    Research-based evidence points to the efficacy and value of applied behavior analysis (ABA) in meeting the needs of individuals with learning disabilities and autism. Nonetheless, public, government, and professional perception of ABA can be negative. The current study was designed to measure the impact of a short intervention on professionals' attitudes toward, and knowledge of, ABA. Teachers and classroom assistants from two separate schools for children with severe learning difficulties completed a self-report survey on knowledge of and attitudes toward ABA. They were then presented with a 90-min training module designed to increase their knowledge of the history of ABA and their functional assessment skills. Following training, the self-report was readministered. The mean scores for each group increased only after the training had been delivered. Further research is needed to address the impact of training on classroom practice.

  1. Undergraduate teaching modules featuring geodesy data applied to critical social topics (GETSI: GEodetic Tools for Societal Issues)

    Science.gov (United States)

    Pratt-Sitaula, B. A.; Walker, B.; Douglas, B. J.; Charlevoix, D. J.; Miller, M. M.

    2015-12-01

    The GETSI project, funded by NSF TUES, is developing and disseminating teaching and learning materials that feature geodesy data applied to critical societal issues such as climate change, water resource management, and natural hazards (serc.carleton.edu/getsi). It is collaborative between UNAVCO (NSF's geodetic facility), Mt San Antonio College, and Indiana University. GETSI was initiated after requests by geoscience faculty for geodetic teaching resources for introductory and majors-level students. Full modules take two weeks but module subsets can also be used. Modules are developed and tested by two co-authors and also tested in a third classroom. GETSI is working in partnership with the Science Education Resource Center's (SERC) InTeGrate project on the development, assessment, and dissemination to ensure compatibility with the growing number of resources for geoscience education. Two GETSI modules are being published in October 2015. "Ice mass and sea level changes" includes geodetic data from GRACE, satellite altimetry, and GPS time series. "Imaging Active Tectonics" has students analyzing InSAR and LiDAR data to assess infrastructure earthquake vulnerability. Another three modules are in testing during fall 2015 and will be published in 2016. "Surface process hazards" investigates mass wasting hazard and risk using LiDAR data. "Water resources and geodesy" uses GRACE, vertical GPS, and reflection GPS data to have students investigating droughts in California and the High Great Plains. "GPS, strain, and earthquakes" helps students learn about infinitesimal and coseismic strain through analysis of horizontal GPS data and includes an extension module on the Napa 2014 earthquake. In addition to teaching resources, the GETSI project is compiling recommendations on successful development of geodesy curricula. The chief recommendations so far are the critical importance of including scientific experts in the authorship team and investing significant resources in

  2. Professional growth of trainees: applying teacher training models to the training of GPs.

    Science.gov (United States)

    Gavriel, George; Gavriel, Jennifer

    2011-10-01

    Study of professional growth is useful for reflective purposes at any time during a career. The concept of known knowns and unknowns with a training twist can be used to summarise the overall stages of any trainee. At the start of vocational training the trainee does not know what they do not know, they have not yet recognised how much they have to learn. This happens in the second stage (that could be equated to survival) when they begin to understand the vast array of skills they must develop to make it look easy. With time and practice they will reach the point where they know what they have to do--not always getting it right but then who does? Finally, and it is particularly important that trainers recognise this, an individual will reach the point where everything is so automatic they are no longer aware of the intricacies of the skills they have acquired. This is where most trainers, both for teachers and GPs, find themselves and this can be frustrating for both trainee and trainer as they find they are unable to communicate effectively. A good trainer will spend time dissecting and 'unlearning' their skills so they are able to teach their trainees successfully. Trainees, meanwhile, must realise that, one day, they will have their own unknown knowns, but they cannot expect it to happen overnight or without substantial effort. In moving forward from our training it is how we deal with repeated survival stages that determines if we can keep doing the job, it is how we deal with the plateau that determines if we will be any good at it--effective on-the-job training leads to lifelong on-the-job learning.

  3. A Comparative Analysis of Models of Bachelors of Arts' Professional Training in Applied Linguistics at the Universities of Ukraine and the USA

    Science.gov (United States)

    Korniienko, Vita

    2014-01-01

    The analysis of scientists' researches from different countries dealing with different aspects of training in the educational systems of developed countries was carried out. The models of Bachelors of Arts in Applied Linguistics professional training in Ukraine were considered. It was analyzed a professional training of Bachelor of Arts in Applied…

  4. Psychological and pedagogical grounds for applying communicative method of teaching foreign languages in higher school with the purpose of realization of students professional orientation

    OpenAIRE

    Yavoruk, O.; Gridneva, S.

    2010-01-01

    The article deals with the notion of “professional orientation”, its components and levels. The principles of communicative method of teaching foreign languages are analyzed from psychological and pedagogical point of view. Expediency of applying the given method with the purpose of realization of students’ professional orientation is substantiated.

  5. Academic freedom and the professional responsibilities of applied ethicists: a comment on Minerva.

    Science.gov (United States)

    Dawson, Angus; Herington, Jonathan

    2014-05-01

    Academic freedom is an important good, but it comes with several responsibilities. In this commentary we seek to do two things. First, we argue against Francesca Minerva's view of academic freedom as presented in her article 'New threats to academic freedom' on a number of grounds. We reject the nature of the absolutist moral claim to free speech for academics implicit in the article; we reject the elitist role for academics as truth-seekers explicit in her view; and we reject a possible more moderate re-construction of her view based on the harm/offence distinction. Second, we identify some of the responsibilities of applied ethicists, and illustrate how they recommend against allowing for anonymous publication of research. Such a proposal points to the wider perils of a public discourse which eschews the calm and careful discussion of ideas. © 2014 John Wiley & Sons Ltd.

  6. Topical Acne Treatments and Pregnancy

    Science.gov (United States)

    ... your health care provider. What are topical acne treatments? Topical acne treatments are medications applied directly on the skin that are used in the treatment of acne and other skin problems. Topical acne treatments can ...

  7. Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: results from a vehicle controlled, double-blind, randomized study.

    Science.gov (United States)

    Grether-Beck, Susanne; Marini, Alessandra; Jaenicke, Thomas; Krutmann, Jean

    2015-01-01

    Infrared A radiation (IRA) from solar sunlight contributes to photoaging of human skin, e.g. by upregulating MMP-1 expression in dermal fibroblasts, indicating the need for photoprotection of human skin against IRA. Up to now, however, there has been no controlled study to show that effective protection of human skin against IRA radiation is possible. Here, we have conducted a randomized, controlled, double-blinded prospective study in 30 healthy volunteers to assess the capacity of an SPF 30 sunscreen versus the same sunscreen supplemented with an antioxidant cocktail containing grape seed extract, vitamin E, ubiquinone and vitamin C to protect human skin against IRA radiation-induced MMP-1 upregulation. As expected, exposure to IRA radiation significantly upregulated MMP-1 expression, as compared to unirradiated skin, and this response was significantly reduced, if the SPF30 sunscreen plus the antioxidant cocktail had been applied prior to IRA radiation. In contrast, treatment of human skin with the SPF30 sunscreen alone did not provide significant protection. These results indicate that topically applied antioxidants effectively protect human skin against IRA radiation and that regular sunscreens need to be supplemented with specific antioxidants in order to achieve IRA photoprotection. © 2014 The American Society of Photobiology.

  8. Topical Drugs for Pain Relief

    Directory of Open Access Journals (Sweden)

    Anjali Srinivasan

    2015-03-01

    Full Text Available Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect.

  9. Organizational methods conditions of formation of motivation at corresponding pedagogical skills to professional-applied physical training

    Directory of Open Access Journals (Sweden)

    Victorya Tsybul’ska

    2014-12-01

    Full Text Available Purpose: to develop organizational and methodological conditions of formation and motivation of students to determine their effectiveness. Materials and Methods: the study was conducted by third year student of the correspondence department of the Faculty of Primary Education (53 people. We used the following methods: survey of theoretical knowledge, motor tests, evaluation methods of physical health (G. Apanasenko, psychological methods of training motivation (T. Ilyina, motivation to succeed (T. Elers, rapid diagnosis empathy (I. Yusupova, methods of mathematical statistics. Results: the factors that affect the state of professionally-applied physical fitness of students of the correspondence department of the Faculty of Primary Education. Conclusions: the proposed organizational and methodological conditions activation independent of external students is the basis for providing in centives for self-study educational materials, improving theoretical knowledge in the field of physical education, increased motor activity through various forms of regular exercise.

  10. Prediction of formulation effects on dermal absorption of topically applied ectoparasiticides dosed in vitro on canine and porcine skin using a mixture-adjusted quantitative structure permeability relationship.

    Science.gov (United States)

    Riviere, J E; Brooks, J D; Collard, W T; Deng, J; de Rose, G; Mahabir, S P; Merritt, D A; Marchiondo, A A

    2014-10-01

    Topical application of ectoparasiticides for flea and tick control is a major focus for product development in animal health. The objective of this work was to develop a quantitative structure permeability relationship (QSPeR) model sensitive to formulation effects for predicting absorption and skin deposition of five topically applied drugs administered in six vehicle combinations to porcine and canine skin in vitro. Saturated solutions (20 μL) of (14) C-labeled demiditraz, fipronil, permethrin, imidacloprid, or sisapronil were administered in single or binary (50:50 v/v) combinations of water, ethanol, and transcutol (6 formulations, n = 4-5 replicates per treatment) nonoccluded to 0.64 cm(2) disks of dermatomed pig or dog skin mounted in flow-through diffusion cells. Perfusate flux over 24 h and skin deposition at termination were determined. Permeability (logKp), absorption, and penetration endpoints were modeled using a four-term Abrahams and Martin (hydrogen-bond donor acidity and basicity, dipolarity/polarizability, and excess molar refractivity) linear free energy QSPeR equation with a mixture factor added to compensate for formulation ingredient interactions. Goodness of fit was judged by r(2) , cross-validation coefficient, coefficients (q(2) s), and Williams Plot to visualize the applicability domain. Formulation composition was the primary determinant of permeation. Compounds generally penetrated dog skin better than porcine skin. The vast majority of permeated penetrant was deposited within the dosed skin relative to transdermal flux, an attribute for ectoparasiticides. The best QSPeR logKp model for pig skin permeation (r(2) = 0.86, q(2) s = 0.85) included log octanol/water partition coefficient as the mixture factor, while for dogs (r(2) = 0.91, q(2) s = 0.90), it was log water solubility. These studies clearly showed that the permeation of topical ectoparasiticides could be well predicted using QSPeR models that account for both the physical

  11. Effect of Topically-Applied Hyaluronic-Acid on Pain and Palatal Epithelial Wound Healing: An Examiner-Blind, Randomized, Controlled Clinical Trial.

    Science.gov (United States)

    Yıldırım, Selin; Özener, Hafize Öztürk; Doğan, Başak; Kuru, Bahar

    2017-09-15

    This study aimed to evaluate the effects of two different concentrations of topical hyaluronic-acid on post-operative patient discomfort and wound healing of palatal donor sites following free gingival graft (FGG) surgery. Thirty-six patients requiring FGG were randomly assigned into three groups in an examiner-blind, randomized-controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% hyaluronic-acid gels were used in the test-1 and -2 groups, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups whereas the wound was covered only with periodontal dressing in the control group. On days 3-7-14 and 21, pain and burning sensation were recorded by using visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3-7-14-21-42. Test groups experienced less pain than the control group on days 3 and 7 (Phealing in terms of epithelization and color match.

  12. The efficacy of a topically applied combination of cyphenothrin and pyriproxyfen against the southern African yellow dog tick, Haemaphysalis elliptica, and the cat flea, Ctenocephalides felis, on dogs

    Directory of Open Access Journals (Sweden)

    J. J. Fourie

    2010-05-01

    Full Text Available The objective of this study was to determine the therapeutic and residual efficacy of a topically applied combination of cyphenothrin (40 % and pyriproxyfen (2 % against the tick Haemaphysalis elliptica and the flea Ctenocephalides felis on dogs. Twelve dogs were infested with 50 ticks 2 days before they were treated and with approximately 100 fleas 6 days before treatment and again 2 days before treatment and with 50 ticks and approximately 100 fleas at weekly intervals thereafter. They were ranked according to their flea counts and sex 5 days before treatment and randomly allocated to an untreated control group of 6 dogs and a treated group of 6 dogs. Ticks and fleas were collected from the dogs 48 h after treatment and 48 h after each infestation and live and dead ticks and live fleas were counted. The counts of ticks and fleas were transformed to geometric means, and efficacy was calculated by comparing these means. The product had a therapeutic efficacy of 83.1 % against H. elliptica and 97.5 % against C. felis 2 days after treatment. The residual period of protection during which efficacy was ≥ 90 % was 5 weeks for both H. elliptica and C. felis.

  13. Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial.

    Science.gov (United States)

    Meyskens, F L; Surwit, E; Moon, T E; Childers, J M; Davis, J R; Dorr, R T; Johnson, C S; Alberts, D S

    1994-04-06

    Retinoids enhance differentiation of most epithelial tissues. Epidemiologic studies have shown an inverse relationship between dietary intake or serum levels of vitamin A and the development of cervical dysplasia and/or cervical cancer. Pilot and phase I investigations demonstrated the feasibility of the local delivery of all-trans-retinoic acid (RA) to the cervix using a collagen sponge insert and cervical cap. A phase II trial produced a clinical complete response rate of 50%. This randomized phase III trial was designed to determine whether topically applied RA reversed moderate cervical intraepithelial neoplasia (CIN) II or severe CIN. Analyses were based on 301 women with CIN (moderate dysplasia, 151 women; severe dysplasia, 150 women), evaluated by serial colposcopy, Papanicolaou cytology, and cervical biopsy. Cervical caps with sponges containing either 1.0 mL of 0.372% beta-trans-RA or a placebo were inserted daily for 4 days when women entered the trial, and for 2 days at months 3 and 6. Patients receiving treatment and those receiving placebo were similar with respect to age, ethnicity, birth-control methods, histologic features of the endocervical biopsy specimen and koilocytotic atypia, and percentage of involvement of the cervix at study. Treatment effects were compared using Fisher's exact test and logistic regression methods. Side effects were recorded, and differences were compared using Fisher's exact test. RA increased the complete histologic regression rate of CIN II from 27% in the placebo group to 43% in the retinoic acid treatment group (P = .041). No treatment difference between the two arms was evident in the severe dysplasia group. More vaginal and vulvar side effects were seen in the patients receiving RA, but these effects were mild and reversible. A short course of locally applied RA can reverse CIN II, but not more advanced dysplasia, with acceptable local side effects. A derivative of vitamin A can reverse or suppress an epithelial

  14. Preparing nursing students to be competent for future professional practice: applying the team-based learning-teaching strategy.

    Science.gov (United States)

    Cheng, Ching-Yu; Liou, Shwu-Ru; Hsu, Tsui-Hua; Pan, Mei-Yu; Liu, Hsiu-Chen; Chang, Chia-Hao

    2014-01-01

    Team-based learning (TBL) has been used for many years in business and science, but little research has focused on its application in nursing education. This quasi-experimental study was to apply the TBL in four nursing courses at a university in Taiwan and to evaluate its effect on students' learning outcomes and behaviors. Adult health nursing, maternal-child nursing, community health nursing, and medical-surgical nursing were the 4 designated courses for this study. Three hundred ninety-nine students in 2-year registered nurse-bachelor of science in nursing, and regular 4-year nursing programs enrolled in the designated courses were contacted. Three hundred eighty-seven students agreed to participate in the data collection. Results showed that the TBL significantly improved the learning behaviors of students in both programs, including class engagement (p learning (p learning behaviors and academic performance. These learning behaviors are important and beneficial for the students' future professional development. The TBL method can be considered for broader application in nursing education. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Fluorouracil Topical

    Science.gov (United States)

    Carac® Cream ... Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions [ ... by years of too much exposure to sunlight). Fluorouracil cream and topical solution are also used to ...

  16. Testosterone Topical

    Science.gov (United States)

    ... growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone topical works by ... clean and completely dry. Open your testosterone topical container. If you are using a packet, fold the ...

  17. Applying Grounded Theory

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, PhD, Hon. PhD

    2014-06-01

    Full Text Available Application of grounded theory (GT is a relatively neglected topic by my colleagues. I have written several chapters in my books on applying GT. Two colleagues, Odis Simmons and Barbara Artinian (2009, as well as Dirks and Mills (2011, and Walsh (2014, have also written about applying GT. In the first two chapters of this book I discuss at length properties of generally applying GT and then professional issues and personal matters when applying of GT. There follows in this book nine chapters, four by me and one by Simmons and one by Artinian and one by Dirks and Mills, that are already published in books on GT, and one by Walsh. Thus, this book ends like a reader which publishes in one place already written work. The reader of this book may experience some redundancy in these chapters, but that is the nature of reader texts as different authors discuss the same ideas and topics.

  18. A multicentre, single-blind, randomized comparison of a fixed clindamycin phosphate/tretinoin gel formulation (Velac) applied once daily and a clindamycin lotion formulation (Dalacin T) applied twice daily in the topical treatment of acne vulgaris.

    Science.gov (United States)

    Zouboulis, C C; Derumeaux, L; Decroix, J; Maciejewska-Udziela, B; Cambazard, F; Stuhlert, A

    2000-09-01

    A successful phase III pilot study compared the efficacy and safety of a fixed clindamycin 1%/tretinoin 0.025% gel formulation (CTG; Velac gel) applied once daily and a clindamycin 1% lotion formulation (CLN; Dalacin T lotion) applied twice daily in the treatment of moderate to severe acne vulgaris. We aimed to follow up this study. The two treatment regimens were compared in a multicentre, single-blind, randomized 12-week investigation of patients with moderate to severe acne vulgaris. At week 12, the mean percentage reduction in non-inflamed lesions (open and closed comedones) was greater in the CTG group compared with the CLN group (P = 0.05). Absolute reductions in open and closed comedones were also greater in the CTG group, consistent with the comedolytic activity of tretinoin. There was a significantly greater absolute reduction in inflamed lesions (pustules, papules and nodules) from baseline to both end-point (last observed efficacy outcome; P = 0.043) and week 12 (P = 0.018) in the CTG group compared with the CLN group. Evaluation of the calculated overall acne severity score, considering all five lesion subtypes, demonstrated a significantly greater mean percentage reduction in the CTG group compared with the CLN group, both at end-point (P = 0.01) and at week 12 (P acne severity according to the Cook scale also demonstrated a significantly greater mean reduction in the CTG group than the CLN group after 12 weeks of therapy (P = 0.007). CTG had a more rapid effect on the onset of improvement compared with CLN; a 50% reduction in total lesion counts by day 60 was found in 77% of patients on CTG compared with 56% receiving CLN (P = 0.003). This was largely due to the reduction in open comedone counts (P = 0. 0006). For all other variables, CTG was at least as effective as CLN. Both treatments were well tolerated. A single daily topical application of Velac gel was superior to Dalacin T lotion applied twice daily in reducing overall acne scores, and was

  19. Leave and professional development benefits

    National Research Council Canada - National Science Library

    Martyniak, Cathleen; Keith, Brian

    2009-01-01

    ...; and professional development leaves such as dedicated research time and sabbaticals. Other professional development topics include financial support and relief from duties for conference attendance...

  20. Using resources of public health centers for education and professional societies to incorporate homeland security topics into public teacher continuing education.

    Science.gov (United States)

    McCarthy, Margaret E

    2003-08-01

    The Department of Education, the Association of Schools of Public Health, and national professional societies dedicated to teaching and dissemination of information for health and education in the public sector can form a clearinghouse on information and manpower on Homeland Security by affiliation with Centers for Public Health Preparedness (CPHP). The state licensed or regional societies can contribute further information and guidelines. In the HPS the Science Teacher Workshop (STW) and Public Education (PEC) Committees can assist a CPHP on radiation issues.

  1. Tacrolimus Topical

    Science.gov (United States)

    Tacrolimus ointment is used to treat the symptoms of eczema (atopic dermatitis; a skin disease that causes ... whose eczema has not responded to another medication. Tacrolimus is in a class of medications called topical ...

  2. Clindamycin Topical

    Science.gov (United States)

    ... are using topical clindamycin.you should know that abrasive or medicated soaps and skin products that contain ... severe or do not go away: dry or peeling skin itching or burning skin redness of skin ...

  3. A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis.

    Science.gov (United States)

    Nasir, A; Bissonnette, R; Maari, C; DuBois, J; Pene Dumitrescu, T; Haddad, J; Yamaguchi, Y; Dalessandro, M

    2018-01-01

    Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long-acting muscarinic antagonist (LAMA) developed as a dermal formulation. This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Clinical effect was a secondary objective, measured by gravimetry and the hyperhidrosis disease severity scale (HDSS). Vehicle was included to evaluate safety. Twenty-three subjects were randomized to either 1.85% UMEC (N = 18) or vehicle (N = 5) once daily. Measurable plasma concentrations were observed in 78% of subjects after the treatment. Nine subjects (50%) on UMEC and two subjects (40%) on vehicle reported AEs, most commonly application site reactions. At Day 15, seven subjects (41%) in UMEC and two subjects (40%) in vehicle had at least a 50% reduction in sweat production. Eight subjects (47%) in UMEC and one subject (20%) in vehicle had at least a two-point reduction in HDSS. No comparisons of treatment arms were planned prospectively. The measurable exposure, acceptable safety and preliminary clinical activity observed in this proof-of-concept study suggest the potential clinical utility of topical UMEC in subjects with axillary hyperhidrosis. © 2017 European Academy of Dermatology and Venereology.

  4. Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing

    Directory of Open Access Journals (Sweden)

    F. R. Henshaw

    2015-01-01

    Full Text Available Aims/Hypothesis. Topical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken. Methods. Full thickness cutaneous wounds in diabetic and nondiabetic control rats were treated topically with 1 μg rhCTGF or vehicle alone, on 2 consecutive days. Wound healing rate was observed on day 14 and wound sites were examined for breaking strength and granulation tissue. In the human study across 32 subjects, serial CTGF regulation was analyzed longitudinally in postdebridement diabetic wound fluid. Results. CTGF treated diabetic wounds had an accelerated closure rate compared with vehicle treated diabetic wounds. Healed skin withstood more strain before breaking in CTGF treated rat wounds. Granulation tissue from CTGF treatment in diabetic wounds showed collagen IV accumulation compared with nondiabetic animals. Wound α-smooth muscle actin was increased in CTGF treated diabetic wounds compared with untreated diabetic wounds, as was macrophage infiltration. Endogenous wound fluid CTGF protein rate of increase in human diabetic foot ulcers correlated positively with foot ulcer healing rate (r=0.406; P<0.001. Conclusions/Interpretation. These data collectively increasingly substantiate a functional role for CTGF in human diabetic foot ulcers.

  5. Clobetasol Topical

    Science.gov (United States)

    ... and as a foam, spray, solution (liquid), and shampoo to apply to the scalp. Clobetasol cream, gel, ... spray are usually applied twice a day. Clobetasol shampoo is usually applied once a day. Follow the ...

  6. The Effects of Topically Applied Glycolic Acid and Salicylic Acid on Ultraviolet Radiation-Induced Erythema, DNA Damage and Sunburn Cell Formation in Human Skin

    Science.gov (United States)

    Kornhauser, Andrija; Wei, Rong-Rong; Yamaguchi, Yuji; Coelho, Sergio G.; Kaidbey, Kays; Barton, Curtis; Takahashi, Kaoruko; Beer, Janusz Z.; Miller, Sharon A.; Hearing, Vincent J.

    2009-01-01

    Background α-Hydroxy acids (αHA) are reported to reduce signs of aging in the skin and are widely used cosmetic ingredients. Several studies suggest that αHA can increase the sensitivity of skin to ultraviolet radiation. More recently, β-hydroxy acids (βHA), or combinations of αHA and βHA have also been incorporated into antiaging skin care products. Concerns have also arisen about increased sensitivity to ultraviolet radiation following use of skin care products containing β-HA. Objective To determine whether topical treatment with glycolic acid, a representative αHA, or with salicylic acid, a βHA, modifies the short-term effects of solar simulated radiation (SSR) in human skin. Methods Fourteen subjects participated in this study. Three of the four test sites on the mid-back of each subject were treated daily Monday - Friday, for a total of 3.5 weeks, with glycolic acid (10%), salicylic acid (2%), or vehicle (control). The fourth site received no treatment. After the last treatment, each site was exposed to SSR, and shave biopsies from all 4 sites were obtained. The endpoints evaluated in this study were erythema (assessed visually and instrumentally), DNA damage and sunburn cell formation. Results Treatment with glycolic acid resulted in increased sensitivity of human skin to SSR, measured as an increase in erythema, DNA damage and sunburn cell formation. Salicylic acid did not produce significant changes in any of these biomarkers. Conclusions Short-term topical application of glycolic acid in a cosmetic formulation increased the sensitivity of human skin to SSR, while a comparable treatment with salicylic acid did not. PMID:19411163

  7. Development Strategy for Continuous Professional Education in the Field of Traditional Applied Arts and Crafts of Russia

    Directory of Open Access Journals (Sweden)

    O V Fedotova

    2011-12-01

    Full Text Available The major factors of the development and perfection of the education system in the field of traditional applied arts and crafts in view of modern requirements are considered in the article.

  8. Permeation of topically applied caffeine from a food by-product in cosmetic formulations: Is nanoscale in vitro approach an option?

    Science.gov (United States)

    Rodrigues, Francisca; Alves, Ana Catarina; Nunes, Claudia; Sarmento, Bruno; Amaral, M Helena; Reis, Salette; Oliveira, M Beatriz P P

    2016-11-20

    The aim of the present work was to develop and evaluate the potential of nanostructured lipid carriers associated with caffeine extracted from Coffee Silverskin (NLC-CS), a food by-product, as a new possible topical therapy of cellulitis. Caffeine gain increasing research interest due to their cosmetic potential, particularly in gynoid lipodystrophy, commonly known as cellulite. NLC-CS were prepared via double emulsion technique using polysorbate 60 as surfactant and characterized for their morphology, particle size, zeta potential, association encapsulation and stability. The in vitro skin permeation studies were performed on Franz diffusion cells using pig skin ear as permeation membrane and the optimized formulation was compared with a hydroalcoholic solution of Coffee silverskin (CS) extract. NLC-CS were within the nanosized range (≈200nm), with a low polydispersity index (vitro skin permeation study demonstrated that NLC-CS had a similar skin permeation profile when compared to caffeine in CS extract. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Neomycin Topical

    Science.gov (United States)

    ... only small amounts of neomycin to scrapes, cuts, burns, sores, and wounds, and do not apply it ... and do not swallow it. Do not apply dressings, bandages, cosmetics, lotions, or other skin medications to ...

  10. Recurrent hamstring muscle injury: applying the limited evidence in the professional football setting with a seven-point programme

    Science.gov (United States)

    Brukner, Peter; Nealon, Andrew; Morgan, Christopher; Burgess, Darren; Dunn, Andrew

    2014-01-01

    Recurrent hamstring injuries are a major problem in sports such as football. The aim of this paper was to use a clinical example to describe a treatment strategy for the management of recurrent hamstring injuries and examine the evidence for each intervention. A professional footballer sustained five hamstring injuries in a relatively short period of time. The injury was managed successfully with a seven-point programme—biomechanical assessment and correction, neurodynamics, core stability, eccentric strengthening, an overload running programme, injection therapies and stretching/relaxation. The evidence for each of these treatment options is reviewed. It is impossible to be definite about which aspects of the programme contributed to a successful outcome. Only limited evidence is available in most cases; therefore, decisions regarding the use of different treatment modalities must be made by using a combination of clinical experience and research evidence. PMID:23322894

  11. Assessment of the Influence of Meal Type on Fluoride Absorption due to Ingestion of professionally Applied Gels.

    Science.gov (United States)

    Cavalli, Andreany M; Rebouças, Adriana G; Zanin, Luciane; Flório, Flávia M

    2016-06-01

    The aim of this study is to assess the influence of eating, prior to application of professionally used gels, on the rate of fluoride absorption due to the ingestion of 1.23% acidulated phosphate fluoride (APF). After fasting for 12 hours, 16 adult volunteers (> 65 kg) ingested two types of meal: Breakfast (n = 8) and Lunch (n = 8). Accidental ingestion of fluoride gel used in molding trays was simulated (12,300 ppm; 61.5 mg F; pH = 4.65) 15 minutes after eating. After ingestion of the fluoride solution, 3 mL of venous blood were collected at the following times: Zero (before ingestion) and 15, 30, 45 minutes, 1, 2, and 3 hours. Fluoride concentrations in blood plasma were determined using an ion selective electrode. With the exception of time 0 (p > 0.05), the average blood plasma concentration of the breakfast group (BG) (0.34 ± 0.04 mg/L) was higher than that of the lunch group (LG) (0.24 ± 0.03 mg/L), with the moment of peak concentration being 2 hours after ingestion for both groups (BG = 0.4 mg/L; LG = 0.28 mg/L). Results reinforce the idea that eating before undergoing professional application of fluoride is a factor of extreme importance regarding its safety, and that the time following a patient's heaviest meal should be the time of choice for planning clinical care. Our results should be considered when planning collective action that involves the application of the gel on children in a school environment, thus ensuring the procedure's safety.

  12. Topical anesthesia

    Directory of Open Access Journals (Sweden)

    Mritunjay Kumar

    2015-01-01

    Full Text Available Topical anesthetics are being widely used in numerous medical and surgical sub-specialties such as anesthesia, ophthalmology, otorhinolaryngology, dentistry, urology, and aesthetic surgery. They cause superficial loss of pain sensation after direct application. Their delivery and effectiveness can be enhanced by using free bases; by increasing the drug concentration, lowering the melting point; by using physical and chemical permeation enhancers and lipid delivery vesicles. Various topical anesthetic agents available for use are eutectic mixture of local anesthetics, ELA-max, lidocaine, epinephrine, tetracaine, bupivanor, 4% tetracaine, benzocaine, proparacaine, Betacaine-LA, topicaine, lidoderm, S-caine patch™ and local anesthetic peel. While using them, careful attention must be paid to their pharmacology, area and duration of application, age and weight of the patients and possible side-effects.

  13. Personal interests as incentive for professional writing; Towards a writing pedagogy for Dutch universities of applied sciences

    NARCIS (Netherlands)

    P.A. Coppen; dr Marianne Boogaard; Marleen Claessens; P.H. van de Ven

    2014-01-01

    The aim of this study is to find design criteria for a writing pedagogy for Dutch universities of applied sciences (also: HBO schools). We analyzed policy and educational documents and interviewed lecturers of three writing courses in three HBO schools. This enabled us to characterize their writing

  14. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...

  15. Organizational aspects of an experimental program for physical education with a strengthened course in professional and applied physical training of future electrical engineers in the railway sector

    Directory of Open Access Journals (Sweden)

    Anzhelika Yefremova

    2017-06-01

    Full Text Available Purpose: to develop an optimized program for physical education with a strengthened course in professional and applied physical training (PAPT for students of railway universities. Material & Methods: analysis and generalization of scientific sources and program-normative documentation on physical education of the higher educational institution of railway transport, survey. Results: the results of the survey of railroad specialists are given. Pilot studies have determined the nature and conditions of professional activity of electrical engineers of railway transport. The experimental program on physical education with the strengthened course of the PAPT of students of railway universities was developed and theoretically justified. Conclusion: structure of the experimental program on physical education with the strengthened course of the PAPT included a theoretical section (8 hours, methodical and practical exercises (6 hours, a practical section (114 hours and a control section (12 hours. The program focuses on improving professionally important physical and psycho-physiological qualities and functions, psychomotor skills and physical performance. The basis of the practical section was the physical exercises from different sections of the current basic curriculum.

  16. Applied information science, engineering and technology selected topics from the field of production information engineering and IT for manufacturing : theory and practice

    CERN Document Server

    Tóth, Tibor

    2014-01-01

    The objective of the book is to give a selection from the papers, which summarize several important results obtained within the framework of the József Hatvany Doctoral School operating at the University of Miskolc, Hungary. In accordance with the three main research areas of the Doctoral School established for Information Science, Engineering and Technology, the papers can be classified into three groups. They are as follows: (1) Applied Computational Science; (2) Production Information Engineering (IT for Manufacturing included); (3) Material Stream Systems and IT for Logistics. As regards the first area, some papers deal with special issues of algorithms theory and its applications, with computing algorithms for engineering tasks, as well as certain issues of data base systems and knowledge intensive systems. Related to the second research area, the focus is on Production Information Engineering with special regard to discrete production processes. In the second research area the papers show some new inte...

  17. The study of irritation and toxicity of Carthami oil aquapuncture solution applied topically to the skin and the eye mucous membrane

    Directory of Open Access Journals (Sweden)

    Kim Hye-Nam

    2000-07-01

    Full Text Available This study was designed to evaluate the effect of the bee venom(BV aqua-acupuncture on the neuronal activities of catecholaminergic(tyrosine hydroxylase : TH, dopamine hydroxylase : DH system in the brainstem. After the BV aqua-acupuncture was applied on Chok-Samni(ST36 and the gluteal part(Blank locus in rats. Also, the number of colocalization between catecholamine containing neurons and Fos immunoreactive neurons were analyzed by using the double immunohistochemical technique. The results of the experiments were summarized as follows : 1 . In DR and LC, Chok-Samni group and the Blank locus group showed more significant increase in the number of colocalization between TH containing neurons and Fos immunoreactive neurons than the control group. Furthermore, Chok-Samni group showed more significant increase than the Blank locus group. Also, in Arc, Chok-Samni group showed more significant increase than the Blank locus group and the control group. 2. In LC, Chok-Samni group showed more significant increase in the number of colocalization between DH containing neurons and Fos immunoreactive neurons than the Blank locus group and the control group. Also, in A5, Chok-Samni group and the Blank locus group showed more significant increase than the control group. Chok-Samni group showed more significant increase than the Blank locus group. However, there was no significant change in A7. Consequently, the BV aqua-acupuncture increased more potent the number of Fos immunoreactive neurons and the activity of catecholaminergic neurons. Furthermore, the BV aqua-acupuncture was more effective on Chok-Samni than Blank locus group. These results indicate that the BV aqua-acupuncture is very effective therapy to control pain. The therapeutic effect of BV aqua-acupunture may associated with the endogenous modulatory system such as catecholamine. Those data from the study can be applied to establish the effective treatment of the BV for pain control in the

  18. Efficacy and speed of kill of a topically applied formulation of dinotefuran-permethrin-pyriproxyfen against weekly tick infestations with Rhipicephalus sanguineus (sensu lato) on dogs.

    Science.gov (United States)

    Blair, Jeffrey; Fourie, Josephus J; Varloud, Marie; Horak, Ivan G

    2016-05-16

    Rhipicephalus sanguineus (sensu lato) is a vector of canine babesiosis, anaplasmosis and ehrlichiosis. In order to reduce the chance of transmission of these diseases, an ectoparasiticide should rapidly repel or kill new infestations with this tick. The primary objective of the present study was to evaluate the treatment and preventive acaricidal efficacy of Vectra® 3D (54.45 mg/ml of dinotefuran, 396.88 mg/ml of permethrin and 4.84 mg/ml of pyriproxyfen) against R. sanguineus (s.l.) measured at 2, 8, and 48 h after treatment and weekly re-infestation. Twenty-four dogs were each infested with 50 adult R. sanguineus (s.l.) on Day -7 and allocated to three groups (n = 8) based on tick counts: an untreated control group (Group 1), and two groups (Groups 2 and 3) treated with Vectra®3D. The dogs in each group were infested with 50 ticks on Day -2. Vectra®3D was administered topically to the dogs on Day 0. Ticks were counted, in situ at 2 and 8 h after treatment on dogs in Groups 1 and 3. Group 3 was then withdrawn from the study and ticks were counted and removed from the dogs in Groups 1 and 2, 48 h after treatment. On Days 7, 14, 21, 28, 35 and 42, the dogs in Groups 1 and 2 were re-infested with 50 ticks, which were then counted in situ at 2 and 8 h, and counted and removed at 48 h after re-infestation. Ticks from the initial infestation were visually unaffected by 2 and 8 h after treatment. However, by 2 h after weekly re-infestation the arithmetic mean (AM) efficacy of Vectra® 3D from Days 7 through 28 ranged from 61.1 to 78.8 %, falling to 60.1 and 47.4 % on Days 35 and 42 respectively. By 8 h after weekly re-infestation, the AM efficacy ranged from 89.1 to 97.4 % falling to 81.4 and 69.8 % on Days 35 and 42 respectively. The AM efficacy 48 h after treatment after the initial infestation was 22.9 % but after weekly re-infestation the efficacy at 48 h ranged from 89.1 to 100.0 %, falling to 86.0 and 81.1 % on Days 35 and 42 respectively

  19. Matrix metalloproteinase-9 expression in retinal ganglion cell layer and effect of topically applied brimonidine tartrate 0.2% therapy on this expression in an endothelin-1-induced optic nerve ischemia model.

    Science.gov (United States)

    Aktas, Zeynep; Gurelik, Gokhan; Göçün, Pinar Uyar; Akyürek, Nalan; Onol, Merih; Hasanreisoğlu, Berati

    2010-06-01

    The purpose of this research is to investigate the expression of matrix metalloproteinase-9 (MMP-9) in retinal ganglion cells (RGC) and the impact of topically applied brimonidine tartrate 0.2% (BMD) on this expression in an endothelin-1 (ET-1)-induced chronic optic nerve (ON) ischemia model of rabbit. Osmotically driven minipumps were implanted in one eye of 16 New Zealand albino rabbits to deliver ET-1 at the constant rate of 0.5 microl/h for 2 weeks. ET-1 was given with (group 3) and without topical BMD therapy (group 1). Groups 2 and 4 were taken as controls. MMP-9 expression by immunohistochemically and proportion of cells undergoing apoptosis in RGC layer were investigated. The correlation between the MMP-9 immunopositivity and the proportion of cells undergoing apoptosis in the RGC layer was evaluated. MMP-9 immunopositivity was found to be significantly higher in both groups 1 and 3 compared to that of the controls. There was no difference between groups 1 and 3 regarding MMP-9 expression (p = 0.495). A positive correlation was found between the proportion of cells undergoing apoptosis and MMP-9 expressions in the RGC layer in group 1 (p = 0.031, r = 0.754). MMP-9 expression in the RGC layer seems to significantly increase in the ET-1-induced chronic ON ischemia model. Topical BMD therapy does not seem to affect this MMP-9 expression.

  20. Applying findings from a systematic review of workplace-based e-learning: implications for health information professionals.

    Science.gov (United States)

    Booth, Andrew; Carroll, Christopher; Papaioannou, Diana; Sutton, Anthea; Wong, Ruth

    2009-03-01

    To systematically review the UK published literature on e-learning in the health workplace and to apply the findings to one of the most prolific UK e-learning initiatives in the health sector--the National Library for Health Facilitated Online Learning Interactive Opportunity (FOLIO) Programme. Sensitive searches were conducted across ASSIA, Australian Education Index, British Education Index, cinahl, CSA Abstracts, Dissertation Abstracts, Emerald, ERIC, IBSS, Index to Theses, LISA, MEDLINE, PSYCINFO and Social Science Citation Index. Additional citations were identified from reference lists of included studies and of relevant reviews; citation tracking and contact with experts. Twenty-nine studies met the inclusion criteria and were coded and analysed using thematic analysis as described by Miles & Huberman (Qualitative Data Analysis: A Sourcebook of New Methods. Newbury Park, CA: Sage, 1984). Five broad themes were identified from the 29 included studies: (i) peer communication; (ii) flexibility; (iii) support; (iv) knowledge validation; and (v) course presentation and design. These broad themes were supported by a total of eleven sub-themes. Components from the FOLIO Programme were analysed and existing and proposed developments were mapped against each sub-theme. This provides a valuable framework for ongoing course development. Librarians involved in delivering and supporting e-learning can benefit from applying the findings from the systematic review to existing programmes, exemplified by the FOLIO Programme. The resultant framework can also be used in developing new e-learning programmes.

  1. When Theory Meets Practice: Applying Cambourne’s Conditions for Learning to Professional Development for Elementary School EFL Teachers

    Directory of Open Access Journals (Sweden)

    Cadavid Múnera Isabel Cristina

    2011-04-01

    Full Text Available

    This article presents a reflection on an action research project carried out by a group of teachers and students at Universidad de Antioquia. The action research project aimed at etermining the impact of a professional development proposal for elementary school English teachers in Medellin, Colombia. In the first section, the article describes the previous study that supported this project as well as its design and implementation. In the second part, Cambourne’s conditions for learning are discussed from a theoretical and practical perspective. Researchers found that participant teachers improved both their use of the foreign language and their pedagogical practices as a result of having the opportunity to take risks and reflect as learners and teachers on holistic strategies for teaching and learning English as a foreign language.

    Este artículo presenta una reflexión acerca de un proyecto de investigación llevado a cabo por un grupo de profesoras y estudiantes de la Universidad de Antioquia. Este proyecto de investigación acción tuvo como objetivo principal determinar el impacto de una propuesta holística de desarrollo profesional para maestros de inglés de la básica primaria, en Medellín, Colombia. En la primera sección del artículo se describen el diseño y la implementación del proyecto así como el estudio anterior que dio origen al presente proyecto. En la segunda parte se discuten las condiciones para el aprendizaje y propuestas por Cambourne, desde una mirada teórica y práctica. Se encontró que los profesores participantes mejoraron en su uso de la lengua extranjera, así como en sus prácticas pedagógicas, como resultado de la toma de riesgos y la reflexión como aprendices y docentes acerca de estrategias holísticas para la enseñanza y el aprendizaje del inglés como lengua extranjera.

  2. Bacitracin Topical

    Science.gov (United States)

    ... not use this medication to treat deep cuts, puncture wounds, animal bites, serious burns, or any injuries ... injured area with soap and water and pat dry thoroughly with a clean towel. Apply a small ...

  3. Efinaconazole Topical

    Science.gov (United States)

    ... toenails before you apply the medication. Remove the cap from the bottle and hold the bottle upside down over your ... the medicaton to each affected toenail. Put the cap back on the bottle and screw it on tightly. Allow your toenails ...

  4. Some topics in applied electrochemical kinetics

    Energy Technology Data Exchange (ETDEWEB)

    Casey, E.J.; Coleman, J.R.; Adams, W.A.

    1980-07-01

    The designer of an electrochemical reactor attempts to minimize the inevitable energy losses associated with irreversible processes. The slow steps, which are the greatest offenders, have to be identified. Fortunately, diagnostic techniques have arisen from developments in electrochemical kinetics -- not only for electrode processes but also for the mass-transfer and phase-separation processes which occur in series and parallel in every electrochemical reactor. Although electroplating, anodizing and electromachining, electrowinning and electrosynthesis are acknowledged as activities also of great importance to Canadian life, in this paper the examples will be drawn from the authors' work on batteries and fuel cells, i.e. from attempts to identify the slow steps and the wasteful side reactions, and to design around them. The mutual influence of theoretical ideas and practical achievements is the unifying theme of this lecture.

  5. Topics in Applied Continuum Mechanics : Symposium

    CERN Document Server

    Ziegler, F

    1974-01-01

    THE FOUNDATIONS OF THERMOELASTICITY-EXPERIMENTS AND THEORY (A. PHILLIPS) 1. Introduction 2. The initial yield surface 4 3. The subsequent yield surface 6 4. Some theoretical consequences 10 References 13 ON THE PHYSICS AND MATHEMATICS OF SELF-STRESSES (E. KRONER) 1. Introduction 22 2. The physical origin of the self-stresses 23 3. Formulation of the mathematical problem of self-stresses 27 4. The method of modified Green's functions 30 5. Concluding remarks 35 References 38 DISTORTION IN MICROPOLAR ELASTICITY (W. NOWACKI) 1. Fundamental relations and equations 39 2. Principle of virtual work 42 3. Theorem of minimum of the complimentary work 43 • 4. Reciprocity theorem 44 5. Equations in displacements and rotations 47 6. Compatibility equations 51 References 57 THE YIELD CRITERION IN THE GENERAL CASE OF NONHOMOGENEOUS STRESS AND DEFORMATION FIELDS (J. A. KONIG and W. OLSZAK) 1. Introduction 58 2. The plasticity condition 61 3. Special cases of the yield condition 62 4. Example: Pure bending 63 5. Criteria f...

  6. Some Topics in Applied Electrochemical Kinetics,

    Science.gov (United States)

    1980-07-01

    reaction, the reversible EMF , the faradait reactions and the side reaction. A corrosion reaction occurs between the Mg and the salt solution which not...fundamentals of redox reactions, but also for control of the concentrations UNCLASSIFIED 8 UNCLASS IFIED of essential enzymes and mediators andliaaui- cancer

  7. Cadet lawyers applied professional training

    Directory of Open Access Journals (Sweden)

    Andrey B. Mednikov

    2011-07-01

    Full Text Available The article studies balance of successive protective actions against armed criminals relative to general physical fitness, emotional stability and will activity, experimentally justifies possibility of protective actions effectiveness improvement by means of cadet lawyers volitional qualities development.

  8. Using Maslow's hierarchy to highlight power imbalances between visiting health professional student volunteers and the host community: An applied qualitative study.

    Science.gov (United States)

    Evans, Tracey; Akporuno, Orezioghene; Owens, Katrina M; Lickers, Brittany; Marlinga, Jazmin; Lin, Henry C; Loh, Lawrence C

    2017-01-01

    Health professional students from high-income countries increasingly participate in short-term experiences in global health (STEGH) conducted abroad. One common criticism of STEGH is the inherent power differential that exists between visiting learners and the local community. To highlight this power differential, this paper explores perceived benefits as described by volunteer and community respondents and applies Maslow's hierarchy of needs to commonly identified themes in each respondent group. A semistructured survey was used to collect qualitative responses from both volunteers and community members located in a Dominican Republic community, that is, a hotspot for traditionally conducted STEGH. Thematic analysis identified themes of perceived benefits from both respondent groups; each group's common themes were then classified and compared within Maslow's hierarchy of needs. Each respondent group identified resource provision as a perceived benefit of STEGH, but volunteer respondents primarily focused on the provision of highly-skilled, complex resources while community respondents focused on basic necessities (food, water, etc.) Volunteer respondents were also the only group to also mention spiritual/religious/life experiences, personal skills development, and relationships as perceived benefits. Applying Maslow's hierarchy thus demonstrates a difference in needs: community respondents focused on benefits that address deficiency needs at the bottom of the hierarchy while volunteers focused on benefits addressing self-transcendence/actualization needs at the top of the hierarchy. The perceived difference in needs met by STEGH between volunteers and the host community within Maslow's hierarchy may drive an inherent power differential. Refocusing STEGH on the relationship level of the hierarchy (i.e., focusing on partnerships) might help mitigate this imbalance and empower host communities.

  9. Topics in Nonlinear Dynamics

    DEFF Research Database (Denmark)

    Mosekilde, Erik

    Through a significant number of detailed and realistic examples this book illustrates how the insights gained over the past couple of decades in the fields of nonlinear dynamics and chaos theory can be applied in practice. Aomng the topics considered are microbiological reaction systems, ecological...... food-web systems, nephron pressure and flow regulation, pulsatile secretion of hormones, thermostatically controlled radiator systems, post-stall maneuvering of aircrafts, transfer electron devices for microwave generation, economic long waves, human decision making behavior, and pattern formation...

  10. Topics in Operator Theory

    CERN Document Server

    Ball, Joseph A; Helton, JWilliam; Rodman, Leiba; Spitkovsky, Iiya

    2010-01-01

    This is the first volume of a collection of original and review articles on recent advances and new directions in a multifaceted and interconnected area of mathematics and its applications. It encompasses many topics in theoretical developments in operator theory and its diverse applications in applied mathematics, physics, engineering, and other disciplines. The purpose is to bring in one volume many important original results of cutting edge research as well as authoritative review of recent achievements, challenges, and future directions in the area of operator theory and its applications.

  11. Professional Exchange: Mapping the Future.

    Science.gov (United States)

    Dingman, Robert L.

    1993-01-01

    New associate editor of Professional Exchange section of "Journal of Mental Health Counseling" discusses importance of section. Lists potential topics suggested in 1989, then adds several other topics to the list. Concludes with guidelines for submission to Professional Exchange section. (NB)

  12. Professionalism in anesthesia.

    Science.gov (United States)

    Yang, Homer

    2017-02-01

    Is professionalism in medicine just another bureaucratic imposition on our practice or a fundamental concept for physicians at all stages in their career? In this review, the historical perspectives of professionalism are explored as well as the what, why, and how questions concerning this topic. The key words "professionalism" and "anesthesia" were used to conduct a search of the PubMed database, the policies and publications of relevant Canadian and international physician regulatory bodies and organizations, historical documents, and other internet publications. Professionalism in anesthesia has a long history. While there are many definitions for professionalism, some very dated, all are based on virtues, behaviour, or professional identity. Professionalism plays a central role in the balance between physician autonomy and social contract, and it has a significant impact on patient safety and medicolegal litigation. Considerable evidence exists to suggest that professionalism must be treated seriously, particularly in these times of social accountability and budgetary pressures.

  13. What Patients Can Tell Us: Topic Analysis for Social Media on Breast Cancer.

    Science.gov (United States)

    Tapi Nzali, Mike Donald; Bringay, Sandra; Lavergne, Christian; Mollevi, Caroline; Opitz, Thomas

    2017-07-31

    Social media dedicated to health are increasingly used by patients and health professionals. They are rich textual resources with content generated through free exchange between patients. We are proposing a method to tackle the problem of retrieving clinically relevant information from such social media in order to analyze the quality of life of patients with breast cancer. Our aim was to detect the different topics discussed by patients on social media and to relate them to functional and symptomatic dimensions assessed in the internationally standardized self-administered questionnaires used in cancer clinical trials (European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire Core 30 [QLQ-C30] and breast cancer module [QLQ-BR23]). First, we applied a classic text mining technique, latent Dirichlet allocation (LDA), to detect the different topics discussed on social media dealing with breast cancer. We applied the LDA model to 2 datasets composed of messages extracted from public Facebook groups and from a public health forum (cancerdusein.org, a French breast cancer forum) with relevant preprocessing. Second, we applied a customized Jaccard coefficient to automatically compute similarity distance between the topics detected with LDA and the questions in the self-administered questionnaires used to study quality of life. Among the 23 topics present in the self-administered questionnaires, 22 matched with the topics discussed by patients on social media. Interestingly, these topics corresponded to 95% (22/23) of the forum and 86% (20/23) of the Facebook group topics. These figures underline that topics related to quality of life are an important concern for patients. However, 5 social media topics had no corresponding topic in the questionnaires, which do not cover all of the patients' concerns. Of these 5 topics, 2 could potentially be used in the questionnaires, and these 2 topics corresponded to a total of 3.10% (523

  14. Topic Model for Graph Mining.

    Science.gov (United States)

    Xuan, Junyu; Lu, Jie; Zhang, Guangquan; Luo, Xiangfeng

    2015-12-01

    Graph mining has been a popular research area because of its numerous application scenarios. Many unstructured and structured data can be represented as graphs, such as, documents, chemical molecular structures, and images. However, an issue in relation to current research on graphs is that they cannot adequately discover the topics hidden in graph-structured data which can be beneficial for both the unsupervised learning and supervised learning of the graphs. Although topic models have proved to be very successful in discovering latent topics, the standard topic models cannot be directly applied to graph-structured data due to the "bag-of-word" assumption. In this paper, an innovative graph topic model (GTM) is proposed to address this issue, which uses Bernoulli distributions to model the edges between nodes in a graph. It can, therefore, make the edges in a graph contribute to latent topic discovery and further improve the accuracy of the supervised and unsupervised learning of graphs. The experimental results on two different types of graph datasets show that the proposed GTM outperforms the latent Dirichlet allocation on classification by using the unveiled topics of these two models to represent graphs.

  15. Comparative efficacy of oral administrated afoxolaner (NexGard™) and fluralaner (Bravecto™) with topically applied permethrin/imidacloprid (Advantix(®)) against transmission of Ehrlichia canis by infected Rhipicephalus sanguineus ticks to dogs

    National Research Council Canada - National Science Library

    Jongejan, Frans; Crafford, Dionne; Erasmus, Heidi; Fourie, Josephus J; Schunack, Bettina

    2016-01-01

    The ability of the topical spot-on Advantix(®) (50 % permethrin/10 % imidacloprid) to prevent transmission of Ehrlichia canis by infected Rhipicephalus sanguineus ticks to dogs has previously been reported...

  16. A study of an ethics education topic for undergraduate nursing students.

    Science.gov (United States)

    Kalaitzidis, Evdokia; Schmitz, Karl

    2012-01-01

    The study aims to explore nursing students' perceptions of the relative value of various aspects of the ethical component of the undergraduate topic, 'Ethics and Law applied to Nursing' (topic NURS2104). To enable time for reflection on ethics in nursing, sampling occurred 1 year after successful completion of the above-mentioned topic and after successful completion of all but the final clinical experience components of the Bachelor of Nursing (BN) degree. A significant proportion of respondents perceived ethics education as relevant to professional practices. It is also noteworthy that the ethical decision-making strategies that had been incorporated into the topic (NURS2104) became transformed by the clinical experience of each particular student. While results of this study are not conclusive, they nevertheless provide important information for future nursing students on the evolutionary development of ethics education. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Evaluating topic models with stability

    CSIR Research Space (South Africa)

    De Waal, A

    2008-11-01

    Full Text Available Topic models are unsupervised techniques that extract likely topics from text corpora, by creating probabilistic word-topic and topic-document associations. Evaluation of topic models is a challenge because (a) topic models are often employed...

  18. Regulatory Information By Topic

    Science.gov (United States)

    EPA develops and enforces regulations that span many environmental topics, from acid rain reduction to wetlands restoration. Each topic listed below may include related laws and regulations, compliance enforcement information, policies guidance

  19. One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.

    Science.gov (United States)

    Denton, Paul W; Othieno, Florence; Martinez-Torres, Francisco; Zou, Wei; Krisko, John F; Fleming, Elisa; Zein, Sima; Powell, Daniel A; Wahl, Angela; Kwak, Youn Tae; Welch, Brett D; Kay, Michael S; Payne, Deborah A; Gallay, Philippe; Appella, Ettore; Estes, Jacob D; Lu, Min; Garcia, J Victor

    2011-08-01

    Recent iPrEx clinical trial results provided evidence that systemic preexposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) can partially prevent rectal HIV transmission in humans. Similarly, we have previously demonstrated that systemic administration of the same FTC-TDF combination efficiently prevented rectal transmission in humanized bone marrow/liver/thymus (BLT) mice. The CAPRISA 004 trial recently demonstrated that topical application of the tenofovir could partially prevent vaginal HIV-1 transmission in humans. To further validate the usefulness of the BLT mouse model for testing HIV prevention strategies, we evaluated the topical administration of tenofovir as used in CAPRISA 004 to prevent vaginal HIV transmission in BLT mice. Our results demonstrate that vaginally administered 1% tenofovir significantly reduced HIV transmission in BLT mice (P = 0.002). Together with the results obtained after systemic antiretroviral PrEP, these topical inhibitor data serve to validate the use of humanized BLT mice to evaluate both systemic and topical inhibitors of HIV transmission. Based on these observations, we tested six additional microbicide candidates for their ability to prevent vaginal HIV transmission: a C-peptide fusion inhibitor (C52L), a membrane-disrupting amphipathic peptide inhibitor (C5A), a trimeric d-peptide fusion inhibitor (PIE12-Trimer), a combination of reverse transcriptase inhibitors (FTC-TDF), a thioester zinc finger inhibitor (TC247), and a small-molecule Rac inhibitor (NSC23766). No protection was seen with the Rac inhibitor NSC23766. The thioester compound TC247 offered partial protection. Significant protection was afforded by FTC-TDF, and complete protection was offered by three different peptide inhibitors tested. Our results demonstrate that these effective topical inhibitors have excellent potential to prevent vaginal HIV transmission in humans.

  20. 21 CFR 868.5170 - Laryngotracheal topical anesthesia applicator.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Laryngotracheal topical anesthesia applicator. 868... topical anesthesia applicator. (a) Identification. A laryngotracheal topical anesthesia applicator is a device used to apply topical anesthetics to a patient's laryngotracheal area. (b) Classification. Class...

  1. Effective Consultation in Educational and Child Psychology Practice: Professional Training for Both Competence and Capability

    Science.gov (United States)

    Kennedy, Emma Kate; Cameron, R. J.; Monsen, Jeremy

    2009-01-01

    How should applied psychology practitioners be prepared to meet an increasingly challenging and unpredictable working context? This article explores some of the key current issues for educational and child psychology practitioners and their professional trainers in the UK with regard to the topic of effective consultation. The article argues that…

  2. Advances in Applied Mechanics

    OpenAIRE

    2013-01-01

    Advances in Applied Mechanics draws together recent significant advances in various topics in applied mechanics. Published since 1948, Advances in Applied Mechanics aims to provide authoritative review articles on topics in the mechanical sciences, primarily of interest to scientists and engineers working in the various branches of mechanics, but also of interest to the many who use the results of investigations in mechanics in various application areas, such as aerospace, chemical, civil, en...

  3. Topical treatments in psoriasis: today and tomorrow

    NARCIS (Netherlands)

    Bos, Jan D.; Spuls, Phyllis I.

    2008-01-01

    Topical therapy in psoriasis is Of use in mild cases. It is also applied as an adjunct to phototherapy and systemic treatments in moderate to severe cases. Long-established pharmaceuticals such as cignolin, tar preparations, and glucocorticoids are still in use. Newer topical agents such as vitamin

  4. Professional Communication through Journal Articles.

    Science.gov (United States)

    Rochester, Maxine K.

    1996-01-01

    Reviews studies of journal articles as a means of professional communication in the field of library and information science. The focus has been on content analysis and bibliometrics, which includes author, topic, and citation analysis. (LAM)

  5. Comparative efficacy of oral administrated afoxolaner (NexGard?) and fluralaner (Bravecto?) with topically applied permethrin/imidacloprid (Advantix?) against transmission of Ehrlichia canis by infected Rhipicephalus sanguineus ticks to dogs

    OpenAIRE

    Jongejan, Frans; Crafford, Dionne; Erasmus, Heidi; Fourie, Josephus J.; Schunack, Bettina

    2016-01-01

    Background The ability of the topical spot-on Advantix? (50?% permethrin/10?% imidacloprid) to prevent transmission of Ehrlichia canis by infected Rhipicephalus sanguineus ticks to dogs has previously been reported. The recent market introduction of chewable tablets containing the novel compounds, afoxolaner (NexGard?) and fluralaner (Bravecto?) enabled us to conduct a comparative efficacy study with respect to the ability of these three products to block transmission of E. canis by ticks to ...

  6. Qualitative content analysis of complementary topical therapies ...

    African Journals Online (AJOL)

    In order to alleviate diabetic foot problems, patients sometimes seek complementary therapies outside the professional context. This paper describes the use of complementary remedies as a topical treatment for diabetic foot ulcers among Jordanians. Qualitative content analysis was used to analyse written responses of 68 ...

  7. Time management and professional identity of students of pedagogical universities

    OpenAIRE

    E. V. Lebedeva; Shchipanova, D. Y.; Konovalova, M. E.; Kutyin, A. O.

    2016-01-01

    Topicality of the problem under research is stipulated by the necessity of personal characteristics consideration in the process of organization of educational and vocational activities of the future teachers in the conditions of educational medium, which sets high requirements to the students' time competence. The aim of the article is to study the influence of time management peculiarities on the components of students' professional identity. The primary research method applied was psychodi...

  8. A Framework for Understanding Lapses in Professionalism Among Medical Students: Applying the Theory of Planned Behavior to Fitness to Practice Cases.

    Science.gov (United States)

    Jha, Vikram; Brockbank, Susannah; Roberts, Trudie

    2016-06-28

    Fitness to practice decisions are often based on a student's digression from the regulations, with limited exploration of the reasoning behind the student's behavior. However, behavior is underpinned by complex, "hidden" variables, including an individual's attitudes and social norms. Examining hidden determinants of professionalism, such as context, interpersonal relationships, social norms, and local cultures, then allows medical educators to develop a richer understanding of unprofessional behavior.In this article, the authors propose the use of the theory of planned behavior (TPB) as a framework to help evaluate unprofessional behavior in students. The TPB is a deliberative processing model that explains how an individual's behavior is underpinned by his or her cognitions, with behavior being primarily dependent on the intention to perform the behavior (behavioral intention). Intention, in turn, is determined by three variables: attitude, subjective norm, and perceived behavioral control.To understand the practical use of the TPB, the authors present four complex, anonymized case studies in which they employed the TPB to help deal with serious professionalism lapses among medical students. The outcomes of these cases as well as the student and program director perspectives, all explained via the TPB variables, are presented. The strengths and limitations of the TPB are discussed.

  9. THE EXPERIENCE OF THE AUTONOMOUS NON-PROFIT ORGANIZATION OF ADDITIONAL PROFESSIONAL EDUCATION “MOSMED” TO IMPLEMENT SHORT-TERM PROGRAMES OF TRAININGS OF PHYSICIANS ON TOPICAL AREAS OF MEDICAL ACTIVITIES

    Directory of Open Access Journals (Sweden)

    Viatcheslav Anatolievich Vladimirtsev

    2017-05-01

    Full Text Available In accordance with the reform of medical education in Russia, the current system of additional professional education of physicians has the task of expanding the list of new short-term trainings programs. The article presents the results of the practice of the Autonomous non-profit organization of additional professional education ”Mosmed» in the preparation and implementation of short-term training programs of physicians. In 2015–2016, this private educational organization have successfully developed 9 new short-term training programs, conducted 17 training courses and held 3 clinical fellowship program. The total number of physicians trained in short-term programs comprise over of 253 trainees. Discussed the possibility of licensed private educational organizations in expanding the market of educational services and increase access to additional medical education in regions remote from the university centers of medical education. Shows the need to continue conducting an on-site short-term courses in the regions of Russia. The conclusion is that the development of scientific-methodical directions, which determines the development and broad inclusion of short-term training programs in the educational process, promotes a real transformation of the system of additional medical education in the Institute of continuing professional development.

  10. Model of recreational and training sessions based on the use of funds aqua professionally applied in the preparation of students of economics

    Directory of Open Access Journals (Sweden)

    Petrenko N. V.

    2014-07-01

    Full Text Available Purpose : study, develop and test a model of health-training exercises with the use of aqua. Material: in the experiment involved 69 students aged 17-18 years. Results : It was found that the developed model has a positive effect on physical performance of students promotes adaptive processes to the future professional activity and improve the learning process. Should consider the following: 1 the means and methods should be adequate aqua morphofunctional features and enhance the activity of the cardiovascular system, general endurance, power capabilities, flexibility, neurobehavioral performance, and 2 as a means of aqua aerobic exercise is advisable to use orientation and moderate intensity, and 3 use tools and techniques aqua should foster interest in a systematic and independent physical activities. Conclusions : the model promotes the development and improvement of the skills and abilities necessary to the future experts in economics.

  11. Effect of clinic experience on pre-service professionals perceptions of applied special needs services. DOI: 10.5007/1980-0037.2011v13n2p145

    Directory of Open Access Journals (Sweden)

    Chris Carpenter

    2011-02-01

    Full Text Available With the understanding that the attitudes and expectations a teacher carries into the classroom directly affect student achievement, this study was administered to evaluate the cognitive affect that clinical experience incorporating individuals with disabilities had on pre-service exercise science professionals. University Students with and without experience in an adapted clinical environment were given surveys covering attitudes and perceptions towards classroom atmosphere, teachers’ instructional techniques, inclusion, and self-efficacy. Data were analyzed and used to determine pedagogical implications. Findings suggest that pre-service educators tend to feel unprepared and ill-equipped to work in an inclusive educational environment. Therefore, pre-service teacher programs should ideally include coursework in adaptive education and experiential components such as practicum, field experience, and clinical experience. In addition, a school-university collaborative relationship can facilitate beneficial outcomes to future educators as well as special needs populations.

  12. Effect of clinic experience on pre-service professionals perceptions of applied special needs services. DOI: 10.5007/1980-0037.2011v13n2p145

    Directory of Open Access Journals (Sweden)

    Chris Carpenter

    2011-03-01

    Full Text Available With the understanding that the attitudes and expectations a teacher carries into the classroom directly affect student achievement, this study was administered to evaluate the cognitive affect that clinical experience incorporating individuals with disabilities had on pre-service exercise science professionals. University Students with and without experience in an adapted clinical environment were given surveys covering attitudes and perceptions towards classroom atmosphere, teachers’ instructional techniques, inclusion, and self-efficacy. Data were analyzed and used to determine pedagogical implications. Findings suggest that pre-service educators tend to feel unprepared and ill-equipped to work in an inclusive educational environment. Therefore, pre-service teacher programs should ideally include coursework in adaptive education and experiential components such as practicum, field experience, and clinical experience. In addition, a school-university collaborative relationship can facilitate beneficial outcomes to future educators as well as special needs populations.

  13. Model of recreational and training sessions based on the use of funds aqua professionally applied in the preparation of students of economics

    Directory of Open Access Journals (Sweden)

    N. V. Petrenko

    2014-08-01

    Full Text Available Purpose : study, develop and test a model of health-training exercises with the use of aqua. Material: in the experiment involved 69 students aged 17-18 years. Results : It was found that the developed model has a positive effect on physical performance of students promotes adaptive processes to the future professional activity and improve the learning process. Should consider the following: 1 the means and methods should be adequate aqua morphofunctional features and enhance the activity of the cardiovascular system, general endurance, power capabilities, flexibility, neurobehavioral performance, and 2 as a means of aqua aerobic exercise is advisable to use orientation and moderate intensity, and 3 use tools and techniques aqua should foster interest in a systematic and independent physical activities. Conclusions : the model promotes the development and improvement of the skills and abilities necessary to the future experts in economics.

  14. Bibliography for Professional Development.

    Science.gov (United States)

    Fehr, Helen, Comp.

    Information published between 1953 and 1970 on the American Indian is included in this annotated bibliography. The bibliography is designed to aid professional development in the field of education and attempts to categorize and separate fields of interest. Major topics are culture, education, ethnology, folklore, art, housing, history, language,…

  15. Economics of professional football

    NARCIS (Netherlands)

    Besters, Lucas

    2018-01-01

    This dissertation contains four chapters, all with a different topic that is of interest from a sports economic perspective. More specifically, from the economic perspective of professional football. Football is the most popular sport within Europe and the data that is used in the analyses stems

  16. Participatory tools working with crops, varieties and seeds. A guide for professionals applying participatory approaches in agrobiodiversity management, crop improvement and seed sector development

    NARCIS (Netherlands)

    Boef, de W.S.; Thijssen, M.H.

    2007-01-01

    Outline to the guide Within our training programmes on local management of agrobiodiversity, participatory crop improvement and the support of local seed supply participatory tools get ample attention. Tools are dealt with theoretically, are practised in class situations, but are also applied in

  17. Creating a Minor in Applied Data Science: Case Western Reserve University Engages Business Leaders to Produce T-Shaped Professionals. A BHEF Case Study

    Science.gov (United States)

    Business-Higher Education Forum, 2016

    2016-01-01

    This case study examines how Business-Higher Education Forum (BHEF) member Case Western Reserve University is integrating T-shaped skills into a minor in applied data science. Through the collaboration of its business and higher education members, BHEF launched the National Higher Education and Workforce Initiative to create new undergraduate…

  18. Topical use of fluorides for caries control.

    Science.gov (United States)

    Pessan, Juliano Pelim; Toumba, Kyriacos Jack; Buzalaf, Marília Afonso Rabelo

    2011-01-01

    Since the early findings on the protective effects of fluoride present in drinking water upon caries incidence and prevalence, intensive research has been conducted in order to determine the benefits, safety, as well as the cost-effectiveness of other modalities of fluoride delivery. The present chapter reviews the various forms of topical fluoride use - professionally and self-applied - with special emphasis on clinical efficacy and possible side effects. The most widely used forms of fluoride delivery have been subject of several systematic reviews, providing strong evidence supporting the use of dentifrices, gels, varnishes and mouth rinses for the control of caries progression. Dentifrices with fluoride concentrations of 1,000 ppm and above have been shown to be clinically effective in caries prevention when compared to a placebo treatment, but the evidence regarding formulations with 450-550 ppm is still subject of debate. Therefore, the recommendation for low-fluoride dentifrice use must take into account both risks and benefits. The evidence for the combined use of two modalities of fluoride application in comparison to a single modality is still inconsistent, implying that more studies with adequate methodology are needed to determine the real benefits of each method. Considering the currently available evidence and risk-benefit aspects, it seems justifiable to recommend the use of fluoridated dentifrices to individuals of all ages, and additional fluoride therapy should also be targeted towards individuals at high caries risk. Copyright © 2011 S. Karger AG, Basel.

  19. Syntacticized topics in Kurmuk

    DEFF Research Database (Denmark)

    Andersen, Torben

    2015-01-01

    This article argues that Kurmuk, a little-described Western Nilotic language, is characterized by a syntacticized topic whose grammatical relation is variable. In this language, declarative clauses have as topic an obligatory preverbal NP which is either a subject, an object or an adjunct. The gr...

  20. A Professional Learning Community Journey

    Directory of Open Access Journals (Sweden)

    Diana Maliszewski

    2008-06-01

    Full Text Available Four teachers (three classroom teachers and a teacher-librarian explain how their school applied a professional learning community framework to its operational practices. They discuss the process, the benefits, and the challenges of professional learning communities.

  1. Topical anesthetic creams.

    Science.gov (United States)

    Kaweski, Susan

    2008-06-01

    Topical anesthetic creams have positive applications in plastic surgery. For certain procedures, they can replace injected local anesthetics. By replacing injections with a topical cream, the negative effects associated with injections, such as pain, needle anxiety, and edema at the surgical site, are eliminated. A variety of U.S. Food and Drug Administration-approved topical anesthetic creams are available for use; however, much care must be taken when prescribing and administering these drugs, as anesthetic creams compounded in nonstandard doses can result in severe toxicity and death. When used appropriately, topical anesthetic creams can provide a safe and effective alternative to other forms of anesthesia. This article provides an overview of topical anesthetic creams, including availability, composition, safety, and efficacy.

  2. Topical therapies for rosacea.

    Science.gov (United States)

    Nally, Jennie B; Berson, Diane S

    2006-01-01

    Therapeutic options for rosacea include topical agents, oral therapies, laser and light treatments, and surgical procedures. Topical therapies play a critical role in the treatment of patients with papulopustular rosacea and erythematotelangiectatic rosacea, and have the ability to effectively minimize certain manifestations of the disease, including papules, pustules, and erythema. The 3 primary agents for the topical treatment of rosacea are metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Each of these therapies is approved for the treatment of rosacea and has been validated by multiple studies. Additional topical therapies including benzoyl peroxide, clindamycin, retinoids, topical steroids, calcineurin inhibitors, and permethrin are not approved for the treatment of rosacea and play variable roles in the management of this condition.

  3. PREFACE: CEWQO Topical Issue CEWQO Topical Issue

    Science.gov (United States)

    Bozic, Mirjana; Man'ko, Margarita

    2009-09-01

    This topical issue of Physica Scripta collects selected peer-reviewed contributions based on invited and contributed talks and posters presented at the 15th Central European Workshop on Quantum Optics (CEWQO) which took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu). On behalf of the whole community took place in Belgrade 29 May-3 June 2008 (http://cewqo08.phy.bg.ac.yu, cewqo08.phy.bg.ac.yu). On behalf of the whole community of the workshop, we thank the referees for their careful reading and useful suggestions which helped to improve all of the submitted papers. A brief description of CEWQO The Central European Workshop on Quantum Optics is a series of conferences started informally in Budapest in 1992. Sometimes small events transform into important conferences, as in the case of CEWQO. Professor Jozsef Janszky, from the Research Institute of Solid State Physics and Optics, is the founder of this series. Margarita Man'ko obtained the following information from Jozsef Janszky during her visit to Budapest, within the framework of cooperation between the Russian and Hungarian Academies of Sciences in 2005. He organized a small workshop on quantum optics in Budapest in 1992 with John Klauder as a main speaker. Then, bearing in mind that a year before Janszky himself was invited by Vladimir Buzek to give a seminar on the same topic in Bratislava, he decided to assign the name 'Central European Workshop on Quantum Optics', considering the seminar in Bratislava to be the first workshop and the one in Budapest the second. The third formal workshop took place in Bratislava in 1993 organized by Vladimir Buzek, then in 1994 (Budapest, by Jozsef Janszky), 1995 and 1996 (Budmerice, Slovakia, by Vladimir Buzek), 1997 (Prague, by Igor Jex), 1999 (Olomouc, Czech Republic, by Zdenek Hradil), 2000 (Balatonfüred, Hungary, by Jozsef Janszky ), 2001 (Prague, by Igor Jex), 2002 (Szeged, Hungary, by Mihaly Benedict), 2003 (Rostock,Germany, by Werner Vogel and

  4. Micro-finite element analysis applied to high-resolution MRI reveals improved bone mechanical competence in the distal femur of female pre-professional dancers.

    Science.gov (United States)

    Chang, G; Rajapakse, C S; Diamond, M; Honig, S; Recht, M P; Weiss, D S; Regatte, R R

    2013-04-01

    Micro-finite element analysis applied to high-resolution (0.234-mm length scale) MRI reveals greater whole and cancellous bone stiffness, but not greater cortical bone stiffness, in the distal femur of female dancers compared to controls. Greater whole bone stiffness appears to be mediated by cancellous, rather than cortical bone adaptation. The purpose of this study was to compare bone mechanical competence (stiffness) in the distal femur of female dancers compared to healthy, relatively inactive female controls. This study had institutional review board approval. We recruited nine female modern dancers (25.7±5.8 years, 1.63±0.06 m, 57.1±4.6 kg) and ten relatively inactive, healthy female controls matched for age, height, and weight (32.1±4.8 years, 1.6±0.04 m, 55.8±5.9 kg). We scanned the distal femur using a 7-T MRI scanner and a three-dimensional fast low-angle shot sequence (TR/TE=31 ms/5.1 ms, 0.234 mm×0.234 mm×1 mm, 80 slices). We applied micro-finite element analysis to 10-mm-thick volumes of interest at the distal femoral diaphysis, metaphysis, and epiphysis to compute stiffness and cross-sectional area of whole, cortical, and cancellous bone, as well as cortical thickness. We applied two-tailed t-tests and ANCOVA to compare groups. Dancers demonstrated greater whole and cancellous bone stiffness and cross-sectional area at all locations (p0.08). At all locations, the percent of intact whole bone stiffness for cortical bone alone was lower in dancers (p0.07), but adjustment for cortical bone cross-sectional area did not (pfemur compared to controls. Elevated whole bone stiffness in dancers may be mediated via cancellous, rather than cortical bone adaptation.

  5. Comparison of topical tretinoin and betamethasone in oral lichen planus

    Directory of Open Access Journals (Sweden)

    Kar H

    1996-01-01

    Full Text Available Thirty-one patients of oral lichen planus were enrolled in this study and two groups were made. Group 1 consisting of 16 patients who applied topical tretinoin 0.05% and Group 2 comprising of 15 patients who were given topical betamethasone dipropionate 0.05%. The patients applying tretinoin showed statistically significant improvement as compared to patients applying betamethasone.

  6. Topical treatment of melasma

    National Research Council Canada - National Science Library

    Bandyopadhyay, Debabrata

    2009-01-01

    .... The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment...

  7. Hypertrichosis by Topical Psoralen

    Directory of Open Access Journals (Sweden)

    K Pavithran

    1984-01-01

    Full Text Available Two cases in which topical psoralen induced hypertrichosis in the depigmented patches of vitiligo are being reported. -The possible mechanisms for this hypertrichosis are briefly discussed.

  8. Diclofenac Topical (osteoarthritis pain)

    Science.gov (United States)

    ... gel (Voltaren) is used to relieve pain from osteoarthritis (arthritis caused by a breakdown of the lining ... Diclofenac topical liquid (Pennsaid) is used to relieve osteoarthritis pain in the knees. Diclofenac is in a ...

  9. Advanced Topics in Aerodynamics

    DEFF Research Database (Denmark)

    Filippone, Antonino

    1999-01-01

    "Advanced Topics in Aerodynamics" is a comprehensive electronic guide to aerodynamics,computational fluid dynamics, aeronautics, aerospace propulsion systems, design and relatedtechnology. We report data, tables, graphics, sketches,examples, results, photos, technical andscientific literature...

  10. Future Specialist’s Professional Position Molding

    Directory of Open Access Journals (Sweden)

    Irina A. Levitskaya

    2013-01-01

    Full Text Available The search of conditions for future specialist’s professional position molding is crucial nowadays. This article discloses the features of “position” notion essence in the context of professional self-determination, analyses the problems of future specialist’s professional development in terms of topical social and professional objectives solution, considers debatable issues of professional development as an integral continuous process of future specialist’s personality formation. The stages of personality professional molding are elaborated. The author determines the relation of professional position with different types of positions (social, personal, role-based. It is mentioned that professional position is determined by professional attitudes and characterizes person’s system of stable value relations towards future professional activities. The relation between the professional position molding and the professional orientation, determining person’s peculiarly experienced selective attitude towards reality, influencing his/her activity is emphasized

  11. Comment on “Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing”

    Directory of Open Access Journals (Sweden)

    Hongling Li

    2015-01-01

    Full Text Available A recent paper in this journal, presented a novel method by topical application of growth factors in stimulating diabetic cutaneous wound healing that caught our attention. We believe that the experimental method in the article is efficient and creative, but it also has some controversies and shortcomings to be discussed. We noted that the authors used “Tegaderm” as a semiocclusive dressing film and stated that it exerted a “splinting effect” on the wound margins and controlled contraction. Indeed, the “Tegaderm” itself can serve as a dressing film to isolate the wound bed with outside environments while the “splinting effect” is mainly achieved by adding silicone splints around the wound. Considering the unique properties of silicone splints and “Tegaderm,” our experimental group propose an alternative method named “combined-suturing” technique that is not only suturing the silicone splints but also securing the “Tegaderm” around the wound. The specific reasons and operative procedures are explained in detail in this letter.

  12. Special topics in the theory of piezoelectricity

    CERN Document Server

    Yang, Jiashi

    2009-01-01

    Piezoelectricity has been a steadily growing field, with recent advances made by researchers from applied physics, acoustics, materials science, and engineering. This collective work presents a comprehensive treatment of selected advanced topics in the subject. The book is written for an intermediate graduate level and is intended for researchers, mechanical engineers, and applied mathematicians interested in the advances and new applications in piezoelectricity.

  13. Topical treatment of melasma.

    Science.gov (United States)

    Bandyopadhyay, Debabrata

    2009-01-01

    Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ) is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

  14. Topical treatment of melasma

    Directory of Open Access Journals (Sweden)

    Bandyopadhyay Debabrata

    2009-01-01

    Full Text Available Melasma is a common hypermelanotic disorder affecting the face that is associated with considerable psychological impacts. The management of melasma is challenging and requires a long-term treatment plan. In addition to avoidance of aggravating factors like oral pills and ultraviolet exposure, topical therapy has remained the mainstay of treatment. Multiple options for topical treatment are available, of which hydroquinone (HQ is the most commonly prescribed agent. Besides HQ, other topical agents for which varying degrees of evidence for clinical efficacy exist include azelaic acid, kojic acid, retinoids, topical steroids, glycolic acid, mequinol, and arbutin. Topical medications modify various stages of melanogenesis, the most common mode of action being inhibition of the enzyme, tyrosinase. Combination therapy is the preferred mode of treatment for the synergism and reduction of untoward effects. The most popular combination consists of HQ, a topical steroid, and retinoic acid. Prolonged HQ usage may lead to untoward effects like depigmentation and exogenous ochronosis. The search for safer alternatives has given rise to the development of many newer agents, several of them from natural sources. Well-designed controlled clinical trials are needed to clarify their role in the routine management of melasma.

  15. Topical antioxidants in radiodermatitis: a clinical review.

    Science.gov (United States)

    Kodiyan, Joyson; Amber, Kyle T

    2015-09-01

    Radiation-induced skin toxicity is the most prevalent side effect of radiation therapy. Not only does it have a significant effect on patients' quality of life, but it also results in poor follow-up and early termination of radiotherapy treatment. Several skin care practices and topical applications have been studied in the field of radiodermatitis, including skin washing, topical steroids, and mechanical skin barriers. Aside from these methods, many patients turn to complementary and alternative medicine for the prevention and treatment of radiodermatitis. Many of these alternative therapies are topically applied antioxidants. While the rationale behind the use of antioxidants in treating radiodermatitis is strong, clinical studies have been far less consistent. Even in large scale randomised controlled trials, findings have been limited by the inconsistent use of topical vehicles and placebos. In this article, the authors review the role of topical antioxidants to better help the practitioner navigate through different available skin directed antioxidants.

  16. Professional Learning Communities: Assessment--Development--Effects.

    Science.gov (United States)

    Hipp, Kristine Kiefer; Huffman, Jane Bumpers

    This presentation addresses three topics: (1) the assessment of professional learning communities in schools; (2) the design and development of professional learning communities in schools; and (3) the effects of professional learning communities in schools. The purpose of this brief document is to share descriptions, processes, and materials…

  17. What is an ICT Professional anyway?

    Directory of Open Access Journals (Sweden)

    Clive Boughton

    2009-08-01

    Full Text Available The intention of this paper is to instigate ongoing discussion surrounding the connected topics of ICT professionalism and the ICT profession. Part of that discussion needs to include suggestions of ‘the way forward’ for the development and recognition of an ICT professional body and the way it should govern/support/protect the professionals within.

  18. Protocol for a randomized controlled dismantling study of a brief telephonic psychological intervention applied to non-professional caregivers with symptoms of depression.

    Science.gov (United States)

    Vázquez, Fernando L; Torres, Ángela; Díaz, Olga; Otero, Patricia; Blanco, Vanessa; Hermida, Elisabet

    2015-11-23

    Although depression is a common problem in caregivers and there are effective cognitive-behavioral interventions for its prevention, the ability of caregivers to attend these treatments is often limited by logistics. Furthermore, the efficacy of the components of these interventions is unknown. The objectives of this study are to (a) evaluate the efficacy of a telephone-administered cognitive-behavioral intervention to prevent depression with all its components (cognitive and behavioral) and only with behavioral activation, and to (b) analyze the mediators of the change in depressive symptoms. A randomized controlled clinical trial was designed to dismantle the components of a cognitive-behavioral intervention. Caregivers with elevated depressive symptoms will be randomly assigned to a cognitive-behavioral intervention, an intervention with only the behavioral activation component, or a usual care control group. Each condition will consist of approximately 60 participants. The two interventions will consist of five sessions lasting 90 min each, applied to groups of about 5 participants at a time via conference call. Trained interviewers, blind to the experimental conditions, will conduct the assessments at the pre-treatment, post-treatment and 1-, 3-, 6- and 12-month follow-ups. This study will provide evidence of the efficacy of a cognitive-behavioral intervention to prevent depression in caregivers with elevated depressive symptoms administered via conference call, and on the impact of the behavioral activation component on the overall efficacy of the program. If we find favorable results, it would mean that we have developed a program of prevention of depression of higher clinical utility and efficacy than those currently available, which would make it possible for a large number of caregivers to have access to such resources. ClinicalTrials.gov: NCT02292394. Registered 6 November 2014.

  19. Traditional Persian topical medications for gastrointestinal diseases

    OpenAIRE

    Laleh Dehghani Tafti; Seyyed Mahyar Shariatpanahi; Mahmoud Mahdavi Damghani; Behjat Javadi

    2017-01-01

    Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI) ailments in Traditional Persian Medicine (TPM). TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study is to survey the topical GI remedies and plant species used as ingredients for these remedies in TPM....

  20. Discriminative Relational Topic Models.

    Science.gov (United States)

    Chen, Ning; Zhu, Jun; Xia, Fei; Zhang, Bo

    2015-05-01

    Relational topic models (RTMs) provide a probabilistic generative process to describe both the link structure and document contents for document networks, and they have shown promise on predicting network structures and discovering latent topic representations. However, existing RTMs have limitations in both the restricted model expressiveness and incapability of dealing with imbalanced network data. To expand the scope and improve the inference accuracy of RTMs, this paper presents three extensions: 1) unlike the common link likelihood with a diagonal weight matrix that allows the-same-topic interactions only, we generalize it to use a full weight matrix that captures all pairwise topic interactions and is applicable to asymmetric networks; 2) instead of doing standard Bayesian inference, we perform regularized Bayesian inference (RegBayes) with a regularization parameter to deal with the imbalanced link structure issue in real networks and improve the discriminative ability of learned latent representations; and 3) instead of doing variational approximation with strict mean-field assumptions, we present collapsed Gibbs sampling algorithms for the generalized relational topic models by exploring data augmentation without making restricting assumptions. Under the generic RegBayes framework, we carefully investigate two popular discriminative loss functions, namely, the logistic log-loss and the max-margin hinge loss. Experimental results on several real network datasets demonstrate the significance of these extensions on improving prediction performance.

  1. Comparative efficacy of oral administrated afoxolaner (NexGard™) and fluralaner (Bravecto™) with topically applied permethrin/imidacloprid (Advantix(®)) against transmission of Ehrlichia canis by infected Rhipicephalus sanguineus ticks to dogs.

    Science.gov (United States)

    Jongejan, Frans; Crafford, Dionne; Erasmus, Heidi; Fourie, Josephus J; Schunack, Bettina

    2016-06-17

    The ability of the topical spot-on Advantix(®) (50 % permethrin/10 % imidacloprid) to prevent transmission of Ehrlichia canis by infected Rhipicephalus sanguineus ticks to dogs has previously been reported. The recent market introduction of chewable tablets containing the novel compounds, afoxolaner (NexGard™) and fluralaner (Bravecto™) enabled us to conduct a comparative efficacy study with respect to the ability of these three products to block transmission of E. canis by ticks to dogs. The speed of kill, immediate drop-off rate and anti-attachment efficacy of the respective products were also studied. The study was a blinded parallel group design, wherein 32 dogs were randomised into four different groups of eight dogs. Group 1 served as negative placebo control, group 2 and 3 were treated on Days 0, 28 and 56 with NexGard™ and Advantix(®), respectively. Group 4 was dosed once on Day 0 with Bravecto™. For tick efficacy assessments 50 non-infected ticks were placed onto the dogs on Days 30, 35, 42, 49, 56, 63, 70, 77 and 84 and on animal tick counts were performed at 3 h, 6 h and 12 h after infestation. To evaluate the ability to block transmission of E. canis, each dog was challenged by releasing 80 adult E. canis-infected R. sanguineus ticks into their sleeping kennels on Days 31, 38, 45 and 52. The animals were monitored for clinical signs of monocytic ehrlichiosis (pyrexia and thrombocytopenia) and were tested for E. canis DNA by PCR and for specific antibodies using IFA. A dog was considered infected with E. canis if both PCR and IFA yielded positive test results up to Day 84. Mean arithmetic tick counts on dogs treated with the Advantix(®) spot-on were significantly (P < 0.0005) lower throughout the study as compared with the negative controls and was, with respect to the speed of kill and resulting onset of acaricidal efficacy, superior over NexGard™ and Bravecto™ at all time points in the 12 h period observed (3 h, 6 h and 12

  2. Conditionals Are Topics

    Science.gov (United States)

    Haiman, John

    1978-01-01

    A review of analyses of conditionals (in the philosophical literature) and of topics (primarily in linguistics) reveals that their definitions are very similar. This paper justifies the method of basing semantic analysis of a construction on a cross-linguistic examination of its superficial form. (Author/NCR)

  3. Differential Topic Models.

    Science.gov (United States)

    Chen, Changyou; Buntine, Wray; Ding, Nan; Xie, Lexing; Du, Lan

    2015-02-01

    In applications we may want to compare different document collections: they could have shared content but also different and unique aspects in particular collections. This task has been called comparative text mining or cross-collection modeling. We present a differential topic model for this application that models both topic differences and similarities. For this we use hierarchical Bayesian nonparametric models. Moreover, we found it was important to properly model power-law phenomena in topic-word distributions and thus we used the full Pitman-Yor process rather than just a Dirichlet process. Furthermore, we propose the transformed Pitman-Yor process (TPYP) to incorporate prior knowledge such as vocabulary variations in different collections into the model. To deal with the non-conjugate issue between model prior and likelihood in the TPYP, we thus propose an efficient sampling algorithm using a data augmentation technique based on the multinomial theorem. Experimental results show the model discovers interesting aspects of different collections. We also show the proposed MCMC based algorithm achieves a dramatically reduced test perplexity compared to some existing topic models. Finally, we show our model outperforms the state-of-the-art for document classification/ideology prediction on a number of text collections.

  4. Selected topics in magnetism

    CERN Document Server

    Gupta, L C

    1993-01-01

    Part of the ""Frontiers in Solid State Sciences"" series, this volume presents essays on such topics as spin fluctuations in Heisenberg magnets, quenching of spin fluctuations by high magnetic fields, and kondo effect and heavy fermions in rare earths amongst others.

  5. Topics for Mathematics Clubs.

    Science.gov (United States)

    Dalton, LeRoy C., Ed.; Snyder, Henry D., Ed.

    The ten chapters in this booklet cover topics not ordinarily discussed in the classroom: Fibonacci sequences, projective geometry, groups, infinity and transfinite numbers, Pascal's Triangle, topology, experiments with natural numbers, non-Euclidean geometries, Boolean algebras, and the imaginary and the infinite in geometry. Each chapter is…

  6. Contrastive topics decomposed

    Directory of Open Access Journals (Sweden)

    Michael Wagner

    2012-12-01

    Full Text Available The analysis of contrastive topics introduced in Büring 1997b and further developed in Büring 2003 relies on distinguishing two types of constituents that introduce alternatives: the sentence focus, which is marked by a FOC feature, and the contrastive topic, which is marked by a CT feature. A non-compositional rule of interpretation that refers to these features is used to derive a topic semantic value, a nested set of sets of propositions. This paper presents evidence for a correlation between the restrictive syntax of nested focus operators and the syntax of contrastive topics, a correlation which is unexpected under this analysis. A compositional analysis is proposed that only makes use of the flatter focus semantic values introduced by focus operators. The analysis aims at integrating insights from the original analysis while at the same time capturing the observed syntactic restrictions. http://dx.doi.org/10.3765/sp.5.8 BibTeX info

  7. Topical immunomodulators in dermatology

    Directory of Open Access Journals (Sweden)

    Khandpur Sujay

    2004-04-01

    Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

  8. Revision topics in otology

    OpenAIRE

    Balasubramanian, Thiagarajan

    2017-01-01

    This e book covers all important topics in otology. Frequently asked exam questions are discussed in detail in this e book. This book will help students of otolaryngology during their exam preparations. This record was migrated from the OpenDepot repository service in June, 2017 before shutting down.

  9. Characters and Topical Diversity

    DEFF Research Database (Denmark)

    Eriksson, Rune

    2014-01-01

    The purpose of this article is to contribute to our understanding of the difference between the bestseller and the non-bestseller in nonfiction. It is noticed that many bestsellers in nonfiction belongs to the sub-genre of creative nonfiction, but also that the topics in this kind of literature i...

  10. Transportation: Topic Paper E.

    Science.gov (United States)

    National Council on the Handicapped, Washington, DC.

    As one of a series of topic papers assessing federal laws and programs affecting persons with disabilities, this paper reviews the issue of transportation services. In the area of urban mass transit, four relevant pieces of legislation and public transportation accessibility regulations are cited, and cost issues are explored. Paratransit systems,…

  11. Choosing a Dissertation Topic.

    Science.gov (United States)

    Useem, Bert

    1997-01-01

    Succinctly summarizes considerations that should be taken into account when choosing a dissertation topic. These include resonance with organizational culture, contribution to the discipline, assistance in a job search, and tractability. Tractability (the ability to produce a finished product) combines the components of scope, clarity of problem,…

  12. Topics and topic prominence in two sign languages

    NARCIS (Netherlands)

    Kimmelman, V.

    2015-01-01

    In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and

  13. Diabetes topics associated with engagement on Twitter.

    Science.gov (United States)

    Harris, Jenine K; Mart, Adelina; Moreland-Russell, Sarah; Caburnay, Charlene A

    2015-05-07

    Social media are widely used by the general public and by public health and health care professionals. Emerging evidence suggests engagement with public health information on social media may influence health behavior. However, the volume of data accumulating daily on Twitter and other social media is a challenge for researchers with limited resources to further examine how social media influence health. To address this challenge, we used crowdsourcing to facilitate the examination of topics associated with engagement with diabetes information on Twitter. We took a random sample of 100 tweets that included the hashtag "#diabetes" from each day during a constructed week in May and June 2014. Crowdsourcing through Amazon's Mechanical Turk platform was used to classify tweets into 9 topic categories and their senders into 3 Twitter user categories. Descriptive statistics and Tweedie regression were used to identify tweet and Twitter user characteristics associated with 2 measures of engagement, "favoriting" and "retweeting." Classification was reliable for tweet topics and Twitter user type. The most common tweet topics were medical and nonmedical resources for diabetes. Tweets that included information about diabetes-related health problems were positively and significantly associated with engagement. Tweets about diabetes prevalence, nonmedical resources for diabetes, and jokes or sarcasm about diabetes were significantly negatively associated with engagement. Crowdsourcing is a reliable, quick, and economical option for classifying tweets. Public health practitioners aiming to engage constituents around diabetes may want to focus on topics positively associated with engagement.

  14. Professional values of nurse lecturers at three universities in Colombia.

    Science.gov (United States)

    López-Pereira, Arabely; Arango-Bayer, Gloria

    2017-03-01

    To describe the professional values of the nurse lectures according to 241 nursing students, who participated voluntarily, in three different universities of Bogotá. This is a quantitative, descriptive cross-sectional study that applied the Nurses Professional Values Scale-permission secured-Spanish; three dimensions of values were applied: ethics, commitment, and professional knowledge. Ethical consideration: Project had ethical review and approval from an ethics committee and participants were given information sheets to read before they agreed to participate in the project. It was concluded that nursing students, in general, do perceive these values in their professors, and they give priority to the dimension of ethics, followed by the knowledge dimension, and finally, commitment. It is evident that professional values are transmitted by professors and students place importance to such values. Values related to the other's care are paramount in nursing training in Colombia as well as in other countries. It was found that participating students observed professors directly in relation to values focused on direct patient care, respect for privacy, respect for life, while matters related to professional improvement, participation in unions were not actually analyzed may be due to poor promotion activities and unions during undergraduate studies. The results obtained are primary approach to the study of values related to nursing, a topic which needs to be researched, something vital to all the country offering nursing training programs.

  15. Tactile friction of topical formulations.

    Science.gov (United States)

    Skedung, L; Buraczewska-Norin, I; Dawood, N; Rutland, M W; Ringstad, L

    2016-02-01

    The tactile perception is essential for all types of topical formulations (cosmetic, pharmaceutical, medical device) and the possibility to predict the sensorial response by using instrumental methods instead of sensory testing would save time and cost at an early stage product development. Here, we report on an instrumental evaluation method using tactile friction measurements to estimate perceptual attributes of topical formulations. Friction was measured between an index finger and an artificial skin substrate after application of formulations using a force sensor. Both model formulations of liquid crystalline phase structures with significantly different tactile properties, as well as commercial pharmaceutical moisturizing creams being more tactile-similar, were investigated. Friction coefficients were calculated as the ratio of the friction force to the applied load. The structures of the model formulations and phase transitions as a result of water evaporation were identified using optical microscopy. The friction device could distinguish friction coefficients between the phase structures, as well as the commercial creams after spreading and absorption into the substrate. In addition, phase transitions resulting in alterations in the feel of the formulations could be detected. A correlation was established between skin hydration and friction coefficient, where hydrated skin gave rise to higher friction. Also a link between skin smoothening and finger friction was established for the commercial moisturizing creams, although further investigations are needed to analyse this and correlations with other sensorial attributes in more detail. The present investigation shows that tactile friction measurements have potential as an alternative or complement in the evaluation of perception of topical formulations. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Developing professional competence

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2015-01-01

    The purpose of university programs for professionals is to qualify the students to act competently in a subsequent job situation. Practical experiences as well as comprehensive research studies have shown that only a limited part of what is learned during the coursework is applied in the subsequent...... professional practice. There is too little transfer from the training programs to application in the workplace. Based on Danish research the relation between school and professional work, between scholastic knowledge and practical knowledge, is analyzed. Guideline for a new and more efficient curricula...

  17. Accelerating Topical Anaesthesia Using Microneedles.

    Science.gov (United States)

    Davies, Lleucu B; Gateley, Christopher; Holland, Phillip; Coulman, Siôn A; Birchall, James C

    2017-09-08

    Topical anaesthetics reduce pain during venous access procedures in children. However, clinical use is hindered by a significant anaesthetic onset time. Restricted diffusion of the topical anaesthetic through the stratum corneum barrier is the principal reason for the delayed onset. Microneedles can painlessly pierce the skin. This study evaluated microneedle pre-treatment of ex vivo human skin as a means to increase the rate of tetracaine permeation, in order to accelerate the onset of anaesthesia. Franz-type diffusion cells were used to determine permeation of a commercial tetracaine formulation, Ametop gel, through human skin epidermis. Microneedle-assisted permeation was compared to untreated epidermis. Upon completion of the permeation studies, the epidermal membranes were visually characterised. At 30 min, 5.43 µg/cm2 of tetracaine had permeated through the untreated membrane compared to 12.13 µg/cm2 through the microneedle-treated membrane. Insertion of a hypodermic needle created a large single channel in the epidermis (approx. 4,250 μm2) whilst the punctured surface area following microneedle treatments was estimated to be 75,000 μm2. Pre-treatment of skin with microneedles significantly enhances the permeation of tetracaine. Microneedles have the potential to more than halve the onset time for anaesthesia when applying Ametop gel. © 2017 S. Karger AG, Basel.

  18. Topical morphine for oral mucositis in children

    DEFF Research Database (Denmark)

    Nielsen, Bettina Nygaard; Aagaard, Gitte; Henneberg, Steen W

    2012-01-01

    Systemic opioids for painful chemotherapy-induced oral mucositis in children often result in unsatisfactory pain relief and a high frequency of side effects. Opioids applied topically can produce analgesia by binding to opioid receptors on peripheral terminals of sensory neurons. These receptors...

  19. Transport phenomena an introduction to advanced topics

    CERN Document Server

    Glasgow, Larry A

    2010-01-01

    Enables readers to apply transport phenomena principles to solve advanced problems in all areas of engineering and science This book helps readers elevate their understanding of, and their ability to apply, transport phenomena by introducing a broad range of advanced topics as well as analytical and numerical solution techniques. Readers gain the ability to solve complex problems generally not addressed in undergraduate-level courses, including nonlinear, multidimensional transport, and transient molecular and convective transport scenarios. Avoiding rote memorization, the author em

  20. Education and Training for Health Professionals

    Science.gov (United States)

    The Cancer Classroom Series is a collection of webinars that highlights topics that provide the educational content, tools, and resources necessary for health professionals, especially those working in public health, to address cancer as a public health problem.

  1. TOPICAL REVIEW: Highly charged ions

    Science.gov (United States)

    Gillaspy, J. D.

    2001-10-01

    This paper reviews some of the fundamental properties of highly charged ions, the methods of producing them (with particular emphasis on table-top devices), and their use as a tool for both basic science and applied technology. Topics discussed include: charge dependence and scaling laws along isoelectronic or isonuclear sequences (for wavefunction size or Bohr radius, ionization energy, dipole transition energy, relativistic fine structure, hyperfine structure, Zeeman effect, Stark effect, line intensities, linewidths, strength of parity violation, etc), changes in angular momentum coupling schemes, selection rules, interactions with surfaces, electron-impact ionization, the electron beam ion trap (EBIT), ion accelerators, atomic reference data, cosmic chronometers, laboratory x-ray astrophysics, vacuum polarization, solar flares, ion implantation, ion lithography, ion microprobes (SIMS and x-ray microscope), nuclear fusion diagnostics, nanotechnology, quantum computing, cancer therapy and biotechnology.

  2. Core continuing professional development (CPD) topics for the European dentist.

    LENUS (Irish Health Repository)

    Bailey, S

    2013-02-01

    In the context of free movement, EU-citizens need assurance that dental practitioners providing their care have a degree\\/license to practice that meets EU-standards and that they maintain their knowledge and skills through ongoing education.

  3. Core continuing professional development (CPD) topics for the European dentist

    NARCIS (Netherlands)

    Bailey, S.; Bullock, A.; Cowpe, J.; Barnes, E.; Thomas, H.; Thomas, R.; Kavadella, A.; Kossioni, A.; Karaharju-Suvanto, T.; Suomalainen, K.; Kersten, H.; Povel, E.; Giles, M.; Walmsley, A.D.; Soboleva, U.; Liepa, A.; Akota, I.

    2013-01-01

    Introduction In the context of free movement, EU-citizens need assurance that dental practitioners providing their care have a degree/license to practice that meets EU-standards and that they maintain their knowledge and skills through ongoing education. Aim One aim of the ‘DentCPD’ project

  4. Using Topic Models to Interpret MEDLINE's Medical Subject Headings

    Science.gov (United States)

    Newman, David; Karimi, Sarvnaz; Cavedon, Lawrence

    We consider the task of interpreting and understanding a taxonomy of classification terms applied to documents in a collection. In particular, we show how unsupervised topic models are useful for interpreting and understanding MeSH, the Medical Subject Headings applied to articles in MEDLINE. We introduce the resampled author model, which captures some of the advantages of both the topic model and the author-topic model. We demonstrate how topic models complement and add to the information conveyed in a traditional listing and description of a subject heading hierarchy.

  5. Salicylic Acid Topical

    Science.gov (United States)

    ... product less often. Talk to your doctor or check the package label for more information.Apply a small amount of the salicylic acid product ... in salicylic acid products. Ask your pharmacist or check the package label for a list of the ingredients.do not apply any of the following products to the skin ...

  6. Influence of topically applied antimicrobial agents on muscular microcirculation.

    Science.gov (United States)

    Goertz, Ole; Hirsch, Tobias; Ring, Andrej; Steinau, Hans U; Daigeler, Adrien; Lehnhardt, Marcus; Homann, Heinz H

    2011-10-01

    Bacterial infections cause major complications in wound healing. Local antiseptics are used for daily wound care; however, their potential toxic effects on the vasculature have not yet been thoroughly investigated. The aim of this study was to assess the effects of antiseptics on microcirculation. Investigations were performed on a standardized cremaster muscle model on rats (n = 60). The arteriolar diameter and functional capillary density (FCD) were investigated using transillumination microscopy before and 60 and 120 minutes after application of each of the following antimicrobial agents: alcohol, hydrogen peroxide, imipenem, octenidine dihydrochloride, polyhexanide, and ethacridine lactate. Although polyhexanide caused a significant arteriolar dilatation (106.25 ± 3.23 vs. 88.54 ± 6.74 μm [baseline value]) and increase of FCD compared with baseline value (12.65 ± 0.82 vs. 9.10 ± 0.50 n/0.22 mm), alcohol led to a significant decrease of both parameters (90.63 ± 10.80 vs. 52.09 ± 7.69 and 5.35 ± 0.54 vs. 1.68 ± 0.48) and was the only agent that caused arteriolar thrombosis. The FCD also increased significantly after treatment with hydrogen peroxide (10.55 ± 0.33 vs. 12.30 ± 0.48) and octenidine (6.82 ± 0.63 vs. 12.32 ± 0.63). However, no positive effect on arteriolar diameter could be found. Ethacridine lactate and imipenem did not impact either parameter. In addition to reducing bacteria, an antiseptic should be nontoxic, especially to the microcirculation. Polyhexanide seems to have a positive influence on vessel diameter and capillary density, whereas alcohol reduces both parameters. If the antimicrobial efficacy is comparable, the antiseptic with less toxic effects should be chosen, especially in critically perfused wounds.

  7. Teaching and assessing veterinary professionalism.

    Science.gov (United States)

    Mossop, Liz H; Cobb, Kate

    2013-01-01

    The teaching and assessment of professional behaviors and attitudes are important components of veterinary curricula. This article aims to outline some important considerations and concepts which will be useful for veterinary educators reviewing or developing this topic. A definition or framework of veterinary professionalism must be decided upon before educators can develop relevant learning outcomes. The interface between ethics and professionalism should be considered, and both clinicians and ethicists should deliver professionalism teaching. The influence of the hidden curriculum on student development as professionals should also be discussed during curriculum planning because it has the potential to undermine a formal curriculum of professionalism. There are several learning theories that have relevance to the teaching and learning of professionalism; situated learning theory, social cognitive theory, adult learning theory, reflective practice and experiential learning, and social constructivism must all be considered as a curriculum is designed. Delivery methods to teach professionalism are diverse, but the teaching of reflective skills and the use of early clinical experience to deliver valid learning opportunities are essential. Curricula should be longitudinal and integrated with other aspects of teaching and learning. Professionalism should also be assessed, and a wide range of methods have the potential to do so, including multisource feedback and portfolios. Validity, reliability, and feasibility are all important considerations. The above outlined approach to the teaching and assessment of professionalism will help ensure that institutions produce graduates who are ready for the workplace.

  8. Topics on continua

    CERN Document Server

    Macias, Sergio

    2005-01-01

    Specialized as it might be, continuum theory is one of the most intriguing areas in mathematics. However, despite being popular journal fare, few books have thoroughly explored this interesting aspect of topology. In Topics on Continua, Sergio Macías, one of the field's leading scholars, presents four of his favorite continuum topics: inverse limits, Jones's set function T, homogenous continua, and n-fold hyperspaces, and in doing so, presents the most complete set of theorems and proofs ever contained in a single topology volume. Many of the results presented have previously appeared only in research papers, and some appear here for the first time. After building the requisite background and exploring the inverse limits of continua, the discussions focus on Professor Jones''s set function T and continua for which T is continuous. An introduction to topological groups and group actions lead to a proof of Effros''s Theorem, followed by a presentation of two decomposition theorems. The author then offers an...

  9. Professional Certification

    Science.gov (United States)

    WaterSense recognizes certification programs for irrigation professionals that meet the specification criteria. Certification programs cover three areas: irrigation system design, installation and maintenance, and system auditing.

  10. Topic and Topic-Comment Constructions in Mandarin Chinese.

    Science.gov (United States)

    Shi, Dingxu

    2000-01-01

    Attempts to provide a precise definition for topic and to derive most of the properties of topic from this definition. The main assumption is that the topic-comment construction is a syntactic device employed to fulfill certain discourse functions. (Author/VWL)

  11. Changing the Topic. Topic Position in Ancient Greek Word Order

    NARCIS (Netherlands)

    Allan, R.J.

    2014-01-01

    Ancient Greek, topics can be expressed as intra-clausal constituents but they can also precede or follow the main clause as extra-clausal constituents. Together, these various topic expressions constitute a coherent system of complementary pragmatic functions. For a comprehensive account of topic

  12. Applied evaluative informetrics

    CERN Document Server

    Moed, Henk F

    2017-01-01

    This book focuses on applied evaluative informetric artifacts or topics. It explains the base notions and assumptions of evaluative informetrics by discussing a series of important applications. The structure of the book is therefore not organized by methodological characteristics, but is centered around popular, often discussed or used informetric artifacts - indicators, methodologies, products, databases - or so called hot topics in which informetric indicators play an important role. Most of the artifacts and topics emerged during the past decade. The principal aim of the book is to present a state of the art in applied evaluative informetrics, and to inform the readers about the pros and cons, potentialities and limitations of the use of informetric/bibliometric indicators in research assessment. The book is a continuation of the book Citation Analysis in Research Evaluation (Springer, 2005). It is of interest to non-specialists, especially research students at advanced master level and higher, all thos...

  13. Professionalism and professional quality of life for oncology nurses.

    Science.gov (United States)

    Jang, Insil; Kim, Yuna; Kim, Kyunghee

    2016-10-01

    To identify the relationship between professionalism and professional quality of life among oncology nurses working at tertiary hospitals in Korea. Oncology nurses are combined with core competencies and qualities required in cancer patient care. Professionalism that means compassion satisfaction and compassion fatigue is a main concept in problem-solving strategies as motivation. Their satisfaction is representative of professionalism and professional quality of life. However, little research has focused on professionalism and professional quality of life. A cross-sectional study with self-administered questionnaires. A total of 285 nurses from two tertiary hospitals were included. Data collection was undertaken using Korean version of professionalism scale derived from the Hall Professional Inventory Scale and professional quality of life. Data were analysed by spss 21.0 for Windows Program using t-test, anova, and multiple regression. The mean score of professionalism in oncology nurses was 77·98 ± 7·31. The mean professional quality of life score for compassion satisfaction, compassion fatigue and secondary traumatic stress was 33·84 ± 5·62, 28·38 ± 5·36 and 28·33 ± 5·48. Compassion satisfaction was affected by factors of professionalism with an explanatory power of 49·2%. Burnout and secondary traumatic stress were affected by factors of professionalism with an explanatory power of 39·3% and 4·8%. The higher the professionalism leads to the higher the compassion satisfaction, the lower the compassion fatigue. The relationship between professionalism and professional quality of life for a health work environment requires further investigation. Our study supports the idea that enhancing professionalism can increase professional quality of life. It is necessary to develop professionalism by recognised qualifications and applied rewards in advanced nursing organisational culture. Furthermore, compassion satisfaction is increased by

  14. Topical antimicrobial agents in ophthalmology. A review

    Directory of Open Access Journals (Sweden)

    E. V. Dovgan’

    2014-01-01

    Full Text Available The data on different antimicrobial agents (fluoroquinolones, minoglycosides, macrolides, fusidic acid, chloramphenicol and their activity against various microorganisms are reviewed. The findings from different researchers are analyzed. Considerable attention is devoted to the problem of antimicrobial resistance in ophthalmology. Pharmacokinetics of topical antimicrobial agents applied in ophthalmology, their safety and tolerability are described. The indications for topical antimicrobial agents use in ophthalmology approved in Russian Federation are presented. With regard for pharmacokinetics and pharmacodynamics, safety profile and good tolerability, it is concluded that fluoroquinolones are medication of choice for empirical antimicrobial treatment in ophthalmology.

  15. Recognizing the professionals who help to solve "the population problem".

    Science.gov (United States)

    Miro, C A

    1984-12-01

    It is the population professionals who belong to the "developing" world who have helped to create and expand the basic information which makes it possible to describe the demographic situation of countries and social groups more adequately. These professionals have developed, promoted, and applied analytical techniques which have enriched understanding of the components of demographic change. It is these professionals who have managed to make major contributions towards explaining the relationship between demographic and socioeconomic factors. The professionals are insisting on developing applied, theoretical, and methodological population research, the results of which will serve essentially to propose alternatives for action. This group of professionals participates daily in the training of technical staff and professionals and academics, specialists who will continue to promote the development of demography as a discipline. Finally, these professionals, through various publications, keep population topics at the center of the attention of those who are concerned with studying them. Groups of countries in Africa, Asia, and Latin America suffer, although to a different extent and in different ways, from the problems created by the rapid growth of certain cities, particularly capital cities. In addition to the problems which may arise from the operation of the specific population dynamics in different countries and between different social groups within those countries, there are those arising from the unequal distribution of agricultural land, foodstuffs, and wealth in general, those arising from the unjust organization of the international economy and from the obsolete international financial structure, and those deriving from the irrational use of resources for military spending and the manufacture and stockpiling of vast nuclear arsenals.

  16. Essays on Applied Economics

    OpenAIRE

    Seixas, Renato Nunes de Lima

    2014-01-01

    This dissertation is comprised of two essays that apply tools from applied microeconomics and empirical methods to study important issues in agriculture, environment and health economics. The unifying topic of the essays is the use of economic reasoning and careful research design to identify causal relationships using observational data.In the first essay, I investigate the environmental effects due to pesticides for two different genetically modified (GM) seeds: insect resistant (IR) cotton...

  17. Topics in mathematical biology

    CERN Document Server

    Hadeler, Karl Peter

    2017-01-01

    This book analyzes the impact of quiescent phases on biological models. Quiescence arises, for example, when moving individuals stop moving, hunting predators take a rest, infected individuals are isolated, or cells enter the quiescent compartment of the cell cycle. In the first chapter of Topics in Mathematical Biology general principles about coupled and quiescent systems are derived, including results on shrinking periodic orbits and stabilization of oscillations via quiescence. In subsequent chapters classical biological models are presented in detail and challenged by the introduction of quiescence. These models include delay equations, demographic models, age structured models, Lotka-Volterra systems, replicator systems, genetic models, game theory, Nash equilibria, evolutionary stable strategies, ecological models, epidemiological models, random walks and reaction-diffusion models. In each case we find new and interesting results such as stability of fixed points and/or periodic orbits, excitability...

  18. Topics in atomic physics

    CERN Document Server

    Burkhardt, Charles E

    2006-01-01

    The study of atomic physics propelled us into the quantum age in the early twentieth century and carried us into the twenty-first century with a wealth of new and, in some cases, unexplained phenomena. Topics in Atomic Physics provides a foundation for students to begin research in modern atomic physics. It can also serve as a reference because it contains material that is not easily located in other sources. A distinguishing feature is the thorough exposition of the quantum mechanical hydrogen atom using both the traditional formulation and an alternative treatment not usually found in textbooks. The alternative treatment exploits the preeminent nature of the pure Coulomb potential and places the Lenz vector operator on an equal footing with other operators corresponding to classically conserved quantities. A number of difficult to find proofs and derivations are included as is development of operator formalism that permits facile solution of the Stark effect in hydrogen. Discussion of the classical hydrogen...

  19. Professional psychology in Portugal.

    Science.gov (United States)

    Fagulha, T; Dana, R H

    1997-12-01

    This paper describes the history and current status of professional psychology in Portugal where a unique perspective combines training, research, and practical contributions from Europe and the Americas with their own history of psychological tradition and expertise. Training in professional psychology includes Social Psychology and Educational and Vocational Guidance specializations in addition to Clinical Psychology and Psychotherapy and Counseling for the professional degree, Licenciatura. Advanced degrees are offered in Environmental Psychology, Career Development, Social Cognition, and other areas, primarily for academic positions. Research in all of these areas is expected to have applied outcomes that contribute to individual well being and an improved quality of life for the entire population. The result has been a rapid development of an indigenous professional psychology to address mental health, social, and environmental concerns that compel psychological attention and resources worldwide as well as those problems of local and national origins.

  20. Health Professionals' Knowledge of Women's Health Care.

    Science.gov (United States)

    Beatty, Rebecca M.

    2000-01-01

    Survey responses from 71 health professionals, benchmarking data from 8 hospitals, continuing education program evaluations, and focus groups with nursing, allied health, and primary care providers indicated a need for professional continuing education on women's health issues. Primary topic needs were identified. The data formed the basis for…

  1. Interpretable Topic Features for Post-ICU Mortality Prediction.

    Science.gov (United States)

    Luo, Yen-Fu; Rumshisky, Anna

    2016-01-01

    Electronic health records provide valuable resources for understanding the correlation between various diseases and mortality. The analysis of post-discharge mortality is critical for healthcare professionals to follow up potential causes of death after a patient is discharged from the hospital and give prompt treatment. Moreover, it may reduce the cost derived from readmissions and improve the quality of healthcare. Our work focused on post-discharge ICU mortality prediction. In addition to features derived from physiological measurements, we incorporated ICD-9-CM hierarchy into Bayesian topic model learning and extracted topic features from medical notes. We achieved highest AUCs of 0.835 and 0.829 for 30-day and 6-month post-discharge mortality prediction using baseline and topic proportions derived from Labeled-LDA. Moreover, our work emphasized the interpretability of topic features derived from topic model which may facilitates the understanding and investigation of the complexity between mortality and diseases.

  2. Professional Visual Basic 2010 and .NET 4

    CERN Document Server

    Sheldon, Bill; Sharkey, Kent

    2010-01-01

    Intermediate and advanced coverage of Visual Basic 2010 and .NET 4 for professional developers. If you've already covered the basics and want to dive deep into VB and .NET topics that professional programmers use most, this is your book. You'll find a quick review of introductory topics-always helpful-before the author team of experts moves you quickly into such topics as data access with ADO.NET, Language Integrated Query (LINQ), security, ASP.NET web programming with Visual Basic, Windows workflow, threading, and more. You'll explore all the new features of Visual Basic 2010 as well as all t

  3. Legal English Through Movies: Development of Professional Communicative Competence

    Directory of Open Access Journals (Sweden)

    Vyushkina Elena

    2016-06-01

    Full Text Available Legal English (LE has evolved as a distinct, highly demanded part of ESP in the recent years of globalisation. Many specialised textbooks have been published lately, but the professional communication aspect lacks sufficient coverage. This article presents a project, which is a teaching manual entitled Legal English through Movies, that has grown from the author’s experience using video in the LE classroom. A general methodology of using authentic video in language teaching is briefly covered to explain why and how feature films were initially used by the author. The idea of using movies for developing law students’ professional communicative competence has shifted the emphasis from pure language training to forming professional communication skills. The applied method takes into consideration both linguistic and extra-linguistic factors of professional communication. Special attention is paid to language patterns typical of different communicative situations within various areas of legal practice along with peculiarities of cross-cultural communication. Not covering all spheres of LE teaching the results enhance education kits for such course topics as Criminal Law, Tort Law, and Civil Procedure as well as provide training materials for mastering professional skills in typical communicative situations (lawyer - client, lawyer - lawyer, etc.. The approach introduced here can be expanded to different ESP fields as well.

  4. Computational technologies advanced topics

    CERN Document Server

    Vabishchevich, Petr N

    2015-01-01

    This book discusses questions of numerical solutions of applied problems on parallel computing systems. Nowadays, engineering and scientific computations are carried out on parallel computing systems, which provide parallel data processing on a few computing nodes. In constructing computational algorithms, mathematical problems are separated in relatively independent subproblems in order to solve them on a single computing node.

  5. Topics in Finance Part VI--Capital Budgeting

    Science.gov (United States)

    Laux, Judy

    2011-01-01

    This series on the theory of financial management offers insight into the roles of stockholder wealth maximization, the risk-return tradeoff, and agency conflicts as they apply to major topics in finance. The current article investigates capital budgeting. Much literature addresses this topic, with a number of articles challenging mainstream…

  6. Superconcentration and related topics

    CERN Document Server

    Chatterjee, Sourav

    2014-01-01

    A certain curious feature of random objects, introduced by the author as “super concentration,” and two related topics, “chaos” and “multiple valleys,” are highlighted in this book. Although super concentration has established itself as a recognized feature in a number of areas of probability theory in the last twenty years (under a variety of names), the author was the first to discover and explore its connections with chaos and multiple valleys. He achieves a substantial degree of simplification and clarity in the presentation of these findings by using the spectral approach. Understanding the fluctuations of random objects is one of the major goals of probability theory and a whole subfield of probability and analysis, called concentration of measure, is devoted to understanding these fluctuations. This subfield offers a range of tools for computing upper bounds on the orders of fluctuations of very complicated random variables. Usually, concentration of measure is useful when more direct prob...

  7. Researching Distressing Topics

    Directory of Open Access Journals (Sweden)

    Sharon Jackson

    2013-05-01

    Full Text Available Qualitative researchers who explore sensitive topics may expose themselves to emotional distress. Consequently, researchers are often faced with the challenge of maintaining emotional equilibrium during the research process. However, discussion on the management of difficult emotions has occupied a peripheral place within accounts of research practice. With rare exceptions, the focus of published accounts is concentrated on the analysis of the emotional phenomena that emerge during the collection of primary research data. Hence, there is a comparative absence of a dialogue around the emotional dimensions of working with secondary data sources. This article highlights some of the complex ways in which emotions enter the research process during secondary analysis, and the ways in which we engaged with and managed emotional states such as anger, sadness, and horror. The concepts of emotional labor and emotional reflexivity are used to consider the ways in which we “worked with” and “worked on” emotion. In doing so, we draw on our collective experiences of working on two collaborative projects with ChildLine Scotland in which a secondary analysis was conducted on children’s narratives of distress, worry, abuse, and neglect.

  8. Topical liquiritin improves melasma.

    Science.gov (United States)

    Amer, M; Metwalli, M

    2000-04-01

    Twenty women with a clinical diagnosis of melasma were treated with liquiritin cream on one side of the face and with a vehicle cream on the other side twice daily for 4 weeks. Patients were advised to avoid sun exposure and/or used topical sunscreen during the entire period of treatment. Inclusion criteria included an age range from 18 to 40 years and bilateral and symmetrical idiopathic epidermal melasma. Exclusion criteria included patients with dermal melasma (differentiated by Wood's light), melasma with pregnancy, and patients currently receiving hormone replacement therapy. Melasma pigmentary intensity was rated on a five-point scale in relation to the patient's normal facial skin (1, no difference; 2, slightly more pigmented; 3, moderately more pigmented; 4, markedly more pigmented; and 5, intensely more pigmented). The size of the lesions was measured directly using a millimeter grid scale. Ratings and measurements were made prior to treatment and at each of the follow-up visits (after 2, 4, 6, 8, and 10 weeks). Clinical evaluation was performed at week 4; the overall response was rated as excellent, good, fair, or poor. Color photographs were taken at the start and at week 4 of the study. Side-effects were observed and treated.

  9. Spectral Learning for Supervised Topic Models.

    Science.gov (United States)

    Ren, Yong; Wang, Yining; Zhu, Jun

    2017-03-15

    Supervised topic models simultaneously model the latent topic structure of large collections of documents and a response variable associated with each document. Existing inference methods are based on variational approximation or Monte Carlo sampling, which often suffers from the local minimum defect. Spectral methods have been applied to learn unsupervised topic models, such as latent Dirichlet allocation (LDA), with provable guarantees. This paper investigates the possibility of applying spectral methods to recover the parameters of supervised LDA (sLDA). We first present a two-stage spectral method, which recovers the parameters of LDA followed by a power update method to recover the regression model parameters. Then, we further present a single-phase spectral algorithm to jointly recover the topic distribution matrix as well as the regression weights. Our spectral algorithms are provably correct and computationally efficient. We prove a sample complexity bound for each algorithm and subsequently derive a sufficient condition for the identifiability of sLDA. Thorough experiments on synthetic and real-world datasets verify the theory and demonstrate the practical effectiveness of the spectral algorithms. In fact, our results on a large-scale review rating dataset demonstrate that our single-phase spectral algorithm alone gets comparable or even better performance than state-of-the-art methods, while previous work on spectral methods has rarely reported such promising performance.

  10. Public understanding of geoscientific topics

    Science.gov (United States)

    Münch, Ute; Lauterjung, Jörn

    2014-05-01

    Geoscientific topics and their consequences for the society are becoming more and more important for our daily life. Natural hazards such as flood and storm or the consequences of the climate change are urgent tasks and great challenges we have to tackle. Cascading natural hazards or environmental risks, can't be evaluated as single events by one scientific discipline, they rather need the expertise of different experts. The same applies for slowly progressive processes such as the climate change and its different aftereffects. More than ever politicians, decision makers, but also the public are asking for comprehensive background information and data to discuss activity options and to develop sustainable solutions. The improvement of public knowledge about science, their assets and drawbacks, chances and risks is getting crucial. To paint a comprehensive picture of different factors, correlations and dependencies the pooling of expertise is required. Thus eight research centres of the research field "Earth and Environment" of the Helmholtz-Association, Germany's largest scientific research organisation are currently building up a knowledge platform. Scientists of different disciplines will provide background information and explain their latest findings in an understandable way. Infographics, maps and animations will be applied to simplify and interpret complicated facts and findings. In addition to the web presence target group-specific products and activities will be organized. To meet the expectations of the different stakeholders an intensive dialog is aspired: round table discussions, exhibitions in museums and public places, tweeds are envisaged. In the beginning the partners will concentrate on the topics "consequences of the climate change", "pollutant dispersion" and "natural hazards/meteorological extreme events". The project is called Earth System Knowledge Platform (ESKP) coordinated by the German Research Centre for Geosciences (GFZ) and the Helmholtz

  11. Applied analysis and differential equations

    CERN Document Server

    Cârj, Ovidiu

    2007-01-01

    This volume contains refereed research articles written by experts in the field of applied analysis, differential equations and related topics. Well-known leading mathematicians worldwide and prominent young scientists cover a diverse range of topics, including the most exciting recent developments. A broad range of topics of recent interest are treated: existence, uniqueness, viability, asymptotic stability, viscosity solutions, controllability and numerical analysis for ODE, PDE and stochastic equations. The scope of the book is wide, ranging from pure mathematics to various applied fields such as classical mechanics, biomedicine, and population dynamics.

  12. Brushing abrasion of eroded bovine enamel pretreated with topical fluorides

    NARCIS (Netherlands)

    Vieira, A; Lugtenborg, M; Ruben, JL; Huysmans, MCDNJM

    2006-01-01

    Topical fluorides have been proposed for the prevention of erosive dental wear. This study evaluated the in vitro effect of a single professional application of 4% titanium tetrafluoride (TiF4), 1% amine fluoride (AmF) and 0.1% difluorosilane varnish (FV) in preventing wear due to combined erosion

  13. Professional Synergy.

    Science.gov (United States)

    Harris, P. R.

    1981-01-01

    True professionals develop and create together a better future by their human endeavors in synergy. They must operate comfortably in two cultures--the industrial culture which is disappearing, and the superindustrial or cyberculture which is emerging. (CT)

  14. Crime Topic Modeling

    OpenAIRE

    Kuang, D; Brantingham, PJ; Bertozzi, AL

    2017-01-01

    The classification of crime into discrete categories entails a massive loss of information. Crimes emerge out of a complex mix of behaviors and situations, yet most of these details cannot be captured by singular crime type labels. This information loss impacts our ability to not only understand the causes of crime, but also how to develop optimal crime prevention strategies. We apply machine learning methods to short narrative text descriptions accompanying crime records wi...

  15. Discovering health topics in social media using topic models.

    Science.gov (United States)

    Paul, Michael J; Dredze, Mark

    2014-01-01

    By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM), as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r = 0.689) and allergies (r = 0.810) temporal surveillance data, as well as exercise (r =  .534) and obesity (r =  -.631) related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media.

  16. Discovering health topics in social media using topic models.

    Directory of Open Access Journals (Sweden)

    Michael J Paul

    Full Text Available By aggregating self-reported health statuses across millions of users, we seek to characterize the variety of health information discussed in Twitter. We describe a topic modeling framework for discovering health topics in Twitter, a social media website. This is an exploratory approach with the goal of understanding what health topics are commonly discussed in social media. This paper describes in detail a statistical topic model created for this purpose, the Ailment Topic Aspect Model (ATAM, as well as our system for filtering general Twitter data based on health keywords and supervised classification. We show how ATAM and other topic models can automatically infer health topics in 144 million Twitter messages from 2011 to 2013. ATAM discovered 13 coherent clusters of Twitter messages, some of which correlate with seasonal influenza (r = 0.689 and allergies (r = 0.810 temporal surveillance data, as well as exercise (r =  .534 and obesity (r =  -.631 related geographic survey data in the United States. These results demonstrate that it is possible to automatically discover topics that attain statistically significant correlations with ground truth data, despite using minimal human supervision and no historical data to train the model, in contrast to prior work. Additionally, these results demonstrate that a single general-purpose model can identify many different health topics in social media.

  17. PROFESSIONAL CATEGORIES

    Directory of Open Access Journals (Sweden)

    Sorin Fildan

    2012-01-01

    Full Text Available The transition process which Romanian commercial law underwent has affected both the term of ‘trader’, by redefining it, and the classification of professional categories. Currently, the term of ‘professional’ is conveyed by a descriptive listing of the categories of persons it comprises: traders, entrepreneurs, business operators, as well as any other person authorized to carry out economic or professional activities.

  18. Topics on the FORM software; Topicos do software FORM

    Energy Technology Data Exchange (ETDEWEB)

    Costa Jorge, Patricia M. da; Peres, Patricia Duarte [Universidade Catolica de Petropolis, RJ (Brazil). Dept. de Ciencia da Computacao

    1997-06-01

    These notes studies the compilation with FORM software as applied to high energy physics, covering the following topics: Command structures, statistics and numbers, Dirac matrices, optimization control, Gamma matrices, errors and polynomial substitution

  19. The Routledge Applied Linguistics Reader

    Science.gov (United States)

    Wei, Li, Ed.

    2011-01-01

    "The Routledge Applied Linguistics Reader" is an essential collection of readings for students of Applied Linguistics. Divided into five sections: Language Teaching and Learning, Second Language Acquisition, Applied Linguistics, Identity and Power and Language Use in Professional Contexts, the "Reader" takes a broad…

  20. Medicare Payment: Surgical Dressings and Topical Wound Care Products.

    Science.gov (United States)

    Schaum, Kathleen D

    2014-08-01

    Medicare patients' access to surgical dressings and topical wound care products is greatly influenced by the Medicare payment system that exists in each site of care. Qualified healthcare professionals should consider these payment systems, as well as the medical necessity for surgical dressings and topical wound care products. Scientists and manufacturers should also consider these payment systems, in addition to the Food and Drug Administration requirements for clearance or approval, when they are developing new surgical dressings and topical wound care products. Due to the importance of the Medicare payment systems, this article reviews the Medicare payment systems in acute care hospitals, long-term acute care hospitals, skilled nursing facilities, home health agencies, durable medical equipment suppliers, hospital-based outpatient wound care departments, and qualified healthcare professional offices.

  1. Experiencias de profesionales de enfermería en terapias alternativas y complementarias aplicadas a personas en situaciones de dolor Experiences of nursing professionals in alternative and complementing therapies applied to people in pain situations

    Directory of Open Access Journals (Sweden)

    BLANCA CECILIA VANEGAS DE AHOGADO

    2008-07-01

    Full Text Available Para conocer las experiencias de profesionales de enfermería en el uso de terapias alternativas y complementarias aplicadas durante el cuidado de la salud a personas en situación de dolor, se realizó un estudio cualitativo, como trabajo de grado de un grupo de estudiantes -de pregrado- de Enfermería de la Uni-versidad El Bosque, entre los años 2005 y 2007, en el que participaron cuatro profesionales de enfermería, con varios años de experiencia en la utilización de Terapia Floral, Acupuntura, Homeopatía, Quiromasaje y Naturopatía; es decir, aquellas terapias que, además permiten una acción sinérgica al combinarse con los procedimientos terapéuticos médico-farmacológicos-quirúrgicos convencionales, a los cuales complementan; la selección de participantes se hizo mediante la técnica de bola de nieve. La información se recogió a través de entrevistas profundas semiestructuradas. El análisis de los resultados, permitió conocer que dichas experiencias no tienen como único propósito aliviar determinado tipo de dolor, sino, por lo general, valorar el estado de salud y hacer las intervenciones con enfoque integral, considerando a la persona como un ser holístico; por otra parte, este trabajo les ha proporcionado a las participantes gran satisfacción y posibilidades de desarrollo personal.To know the experiences of nursing professionals on the use of alternative and complementing therapies applied during health care to people in pain situations, a qualitative study was carried out, as a graduation project for a group of nursing students -undergraduates- from the Universidad del Bosque, between 2005 and 2007, in which four nursing professionals took part. They had several years of experience in the use of floral therapy, acupuncture, homeopathy, chiropractic massage therapy and naturopathy; in other words, those therapies that also enable a synergic action when combined with the conventional therapeutic medical

  2. Experiences of nursing professionals in alternative and complementing therapies applied to people in pain situations Experiencias de profesionales de enfermería en terapias alternativas y complementarias aplicadas a personas en situaciones de dolor

    Directory of Open Access Journals (Sweden)

    MARÍN ARIZA DIEGO ANDRÉS

    2008-07-01

    Full Text Available To know the experiences of nursing professionals on the use of alternative and complementing therapies applied during health care to people in pain situations, a qualitative study was carried out, as a graduation project for a group of nursing students –undergraduates– from the Universidad del Bosque, between 2005 and 2007, in which four nursing professionals took part. They had several years of experience in the use of floral therapy, acupuncture, homeopathy, chiropractic massage therapy and naturopathy; in other words, those therapies that also enable a synergic action when combined with the conventional therapeutic medical-pharmacologic-surgical procedures, which they complement; the selection of participants wasmadeusing the "snow ball" technique. The information was gathered by means of semi-structured deep interviews. The analysis of the results enabled us to learn that said experiences do not have as sole purpose to relieve a determined type of pain, but, generally, to evaluate the health condition and to intervene with an integral focus, considering the individual as a holistic human being; on the other hand, this work has given the students great satisfaction and possibilities for personal development.Para conocer las experiencias de profesionales de enfermería en el uso de terapias alternativas y complementarias aplicadas durante el cuidado de la salud a personas en situación de dolor, se realizó un estudio cualitativo, como trabajo de grado de un grupo de estudiantes –de pregrado– de Enfermería de la Uni-versidad El Bosque, entre los años 2005 y 2007, en el que participaron cuatro profesionales de enfermería, con varios años de experiencia en la utilización de Terapia Floral, Acupuntura, Homeopatía, Quiromasaje y Naturopatía; es decir, aquellas terapias que, además permiten una acción sinérgica al combinarse con los procedimientos terapéuticos médico-farmacológicos-quirúrgicos convencionales, a los cuales

  3. Professionals vs. role-professionals

    DEFF Research Database (Denmark)

    Milana, Marcella; Skrypnyk, Oleksandra

    2010-01-01

    several occupations in the field of adult education that position themselves along a continuum. Consequently the authors suggest that professionalization among adult education practitioners should be assessed in light of the knowledge about adult learning theories practitioners possess, the ethical...

  4. Topics in Bethe Ansatz

    Science.gov (United States)

    Wang, Chunguang

    Integrable quantum spin chains have close connections to integrable quantum field. theories, modern condensed matter physics, string and Yang-Mills theories. Bethe. ansatz is one of the most important approaches for solving quantum integrable spin. chains. At the heart of the algebraic structure of integrable quantum spin chains is. the quantum Yang-Baxter equation and the boundary Yang-Baxter equation. This. thesis focuses on four topics in Bethe ansatz. The Bethe equations for the isotropic periodic spin-1/2 Heisenberg chain with N. sites have solutions containing ±i/2 that are singular: both the corresponding energy and the algebraic Bethe ansatz vector are divergent. Such solutions must be carefully regularized. We consider a regularization involving a parameter that can be. determined using a generalization of the Bethe equations. These generalized Bethe. equations provide a practical way of determining which singular solutions correspond. to eigenvectors of the model. The Bethe equations for the periodic XXX and XXZ spin chains admit singular. solutions, for which the corresponding eigenvalues and eigenvectors are ill-defined. We use a twist regularization to derive conditions for such singular solutions to bephysical, in which case they correspond to genuine eigenvalues and eigenvectors of. the Hamiltonian. We analyze the ground state of the open spin-1/2 isotropic quantum spin chain. with a non-diagonal boundary term using a recently proposed Bethe ansatz solution. As the coefficient of the non-diagonal boundary term tends to zero, the Bethe roots. split evenly into two sets: those that remain finite, and those that become infinite. We. argue that the former satisfy conventional Bethe equations, while the latter satisfy a. generalization of the Richardson-Gaudin equations. We derive an expression for the. leading correction to the boundary energy in terms of the boundary parameters. We argue that the Hamiltonians for A(2) 2n open quantum spin chains

  5. Interdisciplinary Professional Development Needs of Cooperative Extension Field Educators

    Science.gov (United States)

    Sondgerath, Travis

    2016-01-01

    The study discussed in this article sought to identify cross-program professional development needs of county-based Extension professionals (field educators). The study instrument was completed by 105 county-based Extension professionals. Interdisciplinary topics, such as program evaluation and volunteer management, were identified as subjects of…

  6. A Bibliometric Analysis on Cancer Population Science with Topic Modeling.

    Science.gov (United States)

    Li, Ding-Cheng; Rastegar-Mojarad, Majid; Okamoto, Janet; Liu, Hongfang; Leichow, Scott

    2015-01-01

    Bibliometric analysis is a research method used in library and information science to evaluate research performance. It applies quantitative and statistical analyses to describe patterns observed in a set of publications and can help identify previous, current, and future research trends or focus. To better guide our institutional strategic plan in cancer population science, we conducted bibliometric analysis on publications of investigators currently funded by either Division of Cancer Preventions (DCP) or Division of Cancer Control and Population Science (DCCPS) at National Cancer Institute. We applied two topic modeling techniques: author topic modeling (AT) and dynamic topic modeling (DTM). Our initial results show that AT can address reasonably the issues related to investigators' research interests, research topic distributions and popularities. In compensation, DTM can address the evolving trend of each topic by displaying the proportion changes of key words, which is consistent with the changes of MeSH headings.

  7. Professional Use of Social Media by Pharmacists: A Qualitative Study.

    Science.gov (United States)

    Benetoli, Arcelio; Chen, Timothy Frank; Schaefer, Marion; Chaar, Betty B; Aslani, Parisa

    2016-09-23

    Social media is frequently used by consumers and health care professionals; however, our knowledge about its use in a professional capacity by pharmacists is limited. Our aim was to investigate the professional use of social media by pharmacists. In-depth semistructured interviews were conducted with practicing pharmacists (N=31) from nine countries. Interviews were recorded, transcribed verbatim, and thematically analyzed. Wikipedia, YouTube, and Facebook were the main social media platforms used. Professional use of social media included networking with peers, discussion of health and professional topics, accessing and sharing health and professional information, job searching, and professional promotion. Wikipedia was the participants' first choice when seeking information about unfamiliar topics, or topics that were difficult to search for. Very few pharmacy-related contributions to Wikipedia were reported. YouTube, a video-sharing platform, was used for self-education. University lectures, "how-to" footage, and professionally made videos were commonly watched. No professional contribution was made to YouTube. Facebook, a general social networking site, was used for professional networking, promotion of achievements, and job advertisements. It also afforded engagement in professional discussions and information sharing among peers. Participants used social media in a professional capacity, specifically for accessing and sharing health and professional information among peers. Pharmacists, as medicines experts, should take a leading role in contributing to health information dissemination in these user-friendly virtual environments, to reach not only other health care professionals but also health consumers.

  8. Teaching Professional Engineering Skills

    DEFF Research Database (Denmark)

    Andersson, Niclas; Andersson, Pernille Hammar

    2010-01-01

    evaluations, a questionnaire, and discussions with students confirm a genuinely positive attitude towards the role play simulation. The students engage in the role play and express an increased understanding of the requirements and the implicit rules of real-life engineering. The interaction between students....... The underlying argument for this approach is to establish a realistic learning environment that will foster the learning of professional skills. The role play simulation has been applied and reviewed in two engineering courses, i.e. at Lund University in Sweden and at the Technical University of Denmark. Course...... and the professional engineers act as a prime mover for the students to perform their best, which in turn strengthens the learning of the technical content. The study concludes that role play with participation of representatives from the industry can facilitate the teaching of professional skills in engineering...

  9. Topics of Evolutionary Computation 2001

    DEFF Research Database (Denmark)

    Ursem, Rasmus Kjær

    This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem......This booklet contains the student reports from the course: Topics of Evolutionary Computation, Fall 2001, given by Thiemo Krink, Rene Thomsen and Rasmus K. Ursem...

  10. Resources for Topics in Art.

    Science.gov (United States)

    Van Noate, Judith, Comp.

    This guide for conducting library research on topics in art or the work of a particular artist presents suggestions for utilizing four categories of resources: books, dictionaries and encyclopedias, indexes, and a periodicals and serials list (PASL). Three topics are researched as examples: the contemporary artist and author Frank Stella, the…

  11. Empowerment of health professionals: how high level security education can raise awareness and confidence.

    Science.gov (United States)

    Herbst, Matthias; Busch, Christoph; Pharow, Peter; Blobel, Bernd

    2008-01-01

    Setting up networks among physicians and other health professionals in virtually any medical discipline is an important part of establishing eHealth world-wide. Medical research strategies nowadays advance diagnostic and therapeutic knowledge and guidelines allowing patients to benefits. Patient data and samples are among the most sensitive information and must carefully be protected according to rules of ethics and professional discretion as well as national and international privacy legislation. A lot has been said about "patient involvement, patient empowerment". What about health professionals? How can they be involved and empowered to address the paradigm shift towards a personalized health service provision? Information and communication technology (ICT), medical devices, and software applications are not among the topics health professionals typically deal with while being theoretically and practically trained to diagnose diseases and treat patients. An ICT-based training and information provision is required to update the ICT skills of health professionals. The German CAST association provides such an information platform where health professionals attend applied computer security education events. This article aims at describing how ICT and security education is provided to health professionals, and how these training courses are designed, structured, performed, and assessed.

  12. Reducing Stigma in Media Professionals: Is there Room for Improvement? Results from a Systematic Review.

    Science.gov (United States)

    Maiorano, Alessandra; Lasalvia, Antonio; Sampogna, Gaia; Pocai, Benedetta; Ruggeri, Mirella; Henderson, Claire

    2017-10-01

    The mass media may increase stigma against people with mental health problems by reinforcing common stereotypes. Media professionals thus represent a target group for antistigma interventions. This paper aims to review available literature on antistigma interventions for mass media professionals, seeking to clarify what kind of interventions have been found to be effective in reducing mental health stigma among mass media professionals. Six electronic databases (MEDLINE, PsycINFO, Embase, Cochrane Reviews Library and Cochrane Central Register of Controlled Trials, Web of Science, and Applied Social Sciences Index & Abstracts) were systematically searched through March 2017 for studies addressing antistigma interventions on mass media professionals.  Results: A total of 27 studies on antistigma interventions targeted to media professionals were found. Reviewed articles were classified into 3 categories: media-monitoring projects/reporting guidelines ( n = 23), interventions for educating journalists ( n = 2), and interventions for educating journalism students ( n = 2). Overall, antistigma interventions for media professionals seem to have some effect in improving reporting style, thus providing a more balanced portrayal of people with mental health problems: the most promising interventions are contact-based educational approaches and the provision of guidelines by authoritative institutions. It should be useful to promote and disseminate contact-based educational interventions targeted to journalists and to include specific modules on mental health topics in the training curricula of journalism students. However, as research in the field suffers from several limitations, high-quality studies exploring the long-term effect of antistigma interventions for media professionals are needed.

  13. Essentials of applied dynamic analysis

    CERN Document Server

    Jia, Junbo

    2014-01-01

    This book presents up-to-date knowledge of dynamic analysis in engineering world. To facilitate the understanding of the topics by readers with various backgrounds, general principles are linked to their applications from different angles. Special interesting topics such as statistics of motions and loading, damping modeling and measurement, nonlinear dynamics, fatigue assessment, vibration and buckling under axial loading, structural health monitoring, human body vibrations, and vehicle-structure interactions etc., are also presented. The target readers include industry professionals in civil, marine and mechanical engineering, as well as researchers and students in this area.

  14. Caring in Nursing Professional Development.

    Science.gov (United States)

    Martin, Mary Brigid

    2015-01-01

    Caring science has been identified and examined in the discipline of nursing for over 40 years. Within this period, the topic has been analyzed and studied resulting in theories, models, books, and articles published nationally and internationally. Although advancements have been made in caring knowledge development, opportunities to integrate caring science into all aspects of nursing abound, including the specialty of nursing professional development. The focus of this article is to present ways in which nursing professional development specialists may incorporate caring science into practice, using Ray's (2010) Transcultural Caring Dynamics in Nursing and Health Care model as an exceptional exemplar for understanding, awareness, and choice for nurses and patients.

  15. Recent advances in topical anesthesia

    Science.gov (United States)

    2016-01-01

    Topical anesthetics act on the peripheral nerves and reduce the sensation of pain at the site of application. In dentistry, they are used to control local pain caused by needling, placement of orthodontic bands, the vomiting reflex, oral mucositis, and rubber-dam clamp placement. Traditional topical anesthetics contain lidocaine or benzocaine as active ingredients and are used in the form of solutions, creams, gels, and sprays. Eutectic mixtures of local anesthesia cream, a mixture of various topical anesthetics, has been reported to be more potent than other anesthetics. Recently, new products with modified ingredients and application methods have been introduced into the market. These products may be used for mild pain during periodontal treatment, such as scaling. Dentists should be aware that topical anesthetics, although rare, might induce allergic reactions or side effects as a result of an overdose. Topical anesthetics are useful aids during dental treatment, as they reduce dental phobia, especially in children, by mitigating discomfort and pain. PMID:28879311

  16. Recent Developments in Applied Probability and Statistics

    CERN Document Server

    Devroye, Luc; Kohler, Michael; Korn, Ralf

    2010-01-01

    This book presents surveys on recent developments in applied probability and statistics. The contributions include topics such as nonparametric regression and density estimation, option pricing, probabilistic methods for multivariate interpolation, robust graphical modelling and stochastic differential equations. Due to its broad coverage of different topics the book offers an excellent overview of recent developments in applied probability and statistics.

  17. Applied longitudinal analysis

    CERN Document Server

    Fitzmaurice, Garrett M; Ware, James H

    2012-01-01

    Praise for the First Edition "". . . [this book] should be on the shelf of everyone interested in . . . longitudinal data analysis.""-Journal of the American Statistical Association   Features newly developed topics and applications of the analysis of longitudinal data Applied Longitudinal Analysis, Second Edition presents modern methods for analyzing data from longitudinal studies and now features the latest state-of-the-art techniques. The book emphasizes practical, rather than theoretical, aspects of methods for the analysis of diverse types of lo

  18. Topic modelling in the information warfare domain

    CSIR Research Space (South Africa)

    De

    2013-11-01

    Full Text Available In this paper the authors provide context to Topic Modelling as an Information Warfare technique. Topic modelling is a technique that discovers latent topics in unstructured and unlabelled collection of documents. The topic structure can be searched...

  19. Applied analysis

    CERN Document Server

    Lanczos, Cornelius

    1956-01-01

    Basic text for graduate and advanced undergraduate deals with search for roots of algebraic equations encountered in vibration and flutter problems and in those of static and dynamic stability. Other topics devoted to matrices and eigenvalue problems, large-scale linear systems, harmonic analysis and data analysis, more.

  20. Topics in inflationary cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Mahajan, S.

    1986-04-01

    Several aspects of inflationary cosmologies are discussed. An introduction to the standard hot big bang cosmological model is reviewed, and some of the problems associated with it are presented. A short review of the proposals for solving the cosmological conundrums of the big bang model is presented. Old and the new inflationary scenarios are discussed and shown to be unacceptable. Some alternative scenarios especially those using supersymmetry are reviewed briefly. A study is given of inflationary models where the same set of fields that breaks supersymmetry is also responsible for inflation. In these models, the scale of supersymmetry breaking is related to the slope of the potential near the origin and can thus be kept low. It is found that a supersymmetry breaking scale of the order of the weak breaking scale. The cosmology obtained from the simplest of such models is discussed in detail and it is shown that there are no particular problems except a low reheating temperature and a violation of the thermal constraint. A possible solution to the thermal constraint problem is given by introducing a second field, and the role played by this second field in the scenario is discussed. An alternative mechanism for the generation of baryon number within the framework of supergravity inflationary models is studied using the gravitational couplings of the heavy fields with the hidden sector (the sector which breaks supersymmetry). This mechanism is applied to two specific models - one with and one without supersymmetry breaking. The baryon to entropy ratio is found to be dependent on parameters which are model dependent. Finally, the effect of direct coupling between the two sectors on results is related, 88 refs., 6 figs.

  1. Topical menthol increases cutaneous blood flow.

    Science.gov (United States)

    Craighead, Daniel H; Alexander, Lacy M

    2016-09-01

    Menthol, the active ingredient in several topically applied analgesics, activates transient receptor potential melastatin 8 (TRPM8) receptors on sensory nerves and on the vasculature inducing a cooling sensation on the skin. Ilex paraguariensis is also a common ingredient in topical analgesics that has potential vasoactive properties and may alter the mechanisms of action of menthol. We sought to characterize the microvascular effects of topical menthol and ilex application and to determine the mechanism(s) through which these compounds may independently and combined alter cutaneous blood flow. We hypothesized that menthol would induce vasoconstriction and that ilex would not alter skin blood flow (SkBF). Three separate protocols were conducted to examine menthol and ilex-mediated changes in SkBF. In protocol 1, placebo, 4% menthol, 0.7% ilex, and combination menthol+ilex gels were applied separately to the skin and red cell flux was continuously measured utilizing laser speckle contrast imaging (LSCI). In protocol 2, seven concentrations of menthol gel (0.04%, 0.4%, 1%, 2%, 4%, 7%, 8%) were applied to the skin to model the dose-response curve. In protocol 3, placebo, menthol, ilex, and menthol+ilex gels were applied to skin under local thermal control (34°C) both with and without sensory nerve blockage (topical lidocaine 4%). Post-occlusive reactive hyperemia (PORH) and local heating (42°C) protocols were conducted to determine the relative contribution of endothelium derived hyperpolarizing factors (EDHFs)/sensory nerves and nitric oxide (NO), respectively. Red cell flux was normalized to mean arterial pressure expressed as cutaneous vascular conductance (CVC: flux·mmHg(-1)) in all protocols. Topical menthol application increased SkBF compared to placebo (3.41±0.33 vs 1.1±0.19CVC: pmenthol (main effect, pmenthol application during PORH (3.62±0.29 vs. 2.50±0.21flux·mmHg(-1); pmenthol-mediated vasodilation at thermoneutral baseline (1.29±0.19flux·mmHg(-1

  2. Introduction to applied thermodynamics

    CERN Document Server

    Helsdon, R M; Walker, G E

    1965-01-01

    Introduction to Applied Thermodynamics is an introductory text on applied thermodynamics and covers topics ranging from energy and temperature to reversibility and entropy, the first and second laws of thermodynamics, and the properties of ideal gases. Standard air cycles and the thermodynamic properties of pure substances are also discussed, together with gas compressors, combustion, and psychrometry. This volume is comprised of 16 chapters and begins with an overview of the concept of energy as well as the macroscopic and molecular approaches to thermodynamics. The following chapters focus o

  3. Topics in Collider Physics

    Energy Technology Data Exchange (ETDEWEB)

    Petriello, Frank J

    2003-08-27

    rapidity distribution in the Drell-Yan process, an important discovery channel for new physics at hadron colliders. We introduce a powerful new method for calculating differential distributions in hard scattering processes. We apply our results to the analysis of fixed target experiments, which provide important constraints on the parton distribution functions of the proton.

  4. Topics in lightwave transmission systems

    CERN Document Server

    Li, Tingye

    1991-01-01

    Topics in Lightwave Transmission Systems is a second volume of a treatise on optical fiber communications that is devoted to the science, engineering, and application of information transmission via optical fibers. The first volume, published in 1985, dealt exclusively with fiber fabrication. The present volume contains topics that pertain to subsystems and systems. The book contains five chapters and begins with discussions of transmitters and receivers, which are basic to systems now operating in the field. Subsequent chapters cover topics relating to coherent systems: frequency and phase m

  5. Information professionals: core competencies and professional development

    Directory of Open Access Journals (Sweden)

    Flávia Ferreira

    2007-01-01

    Full Text Available Introduction. We discuss the concept of core competencies applied to policies for teaching and training information professionals, particularly librarians. Method. Sixty graduates of the Institute were employed as information professionals. These sixty were asked to attribute degrees of importance to specific items associated with knowledge and skills that, within the scope of this research, were considered core competencies for meeting the demands of their jobs. Participants were also asked to cite knowledge they acquired in school and knowledge they use in exercising their profession, the skills that they consider necessary but that they did not gain in school, and the difficulties they encounter in exercising their profession and for which they were not sufficiently well prepared. Analysis. Both quantitative and qualitative data analyses were performed. The data were tabulated using Access and several reports and cross-tabulations were generated. Results. The results suggest a gulf between knowledge and skills acquired in library school and those that are required by the job market. In particular, participants lacked the skills they needed to work with information and communication technologies. Conclusion. The concept of core competencies is increasingly taken into account by the productive sector of the economy. The educational system ought to keep up with this change. The empirical research described shows that there is a need to establish advanced and modern policies for the education of librarians, participants in the market for information professionals.

  6. Key lessons for designing health literacy professional development courses.

    Science.gov (United States)

    Naccarella, Lucio; Murphy, Bernice

    2017-11-02

    Health literacy courses for health professionals have emerged in response to health professionals' perceived lack of understanding of health literacy issues, and their failure to routinely adopt health literacy practices. Since 2013 in Victoria, Australia, the Centre for Culture, Ethnicity and Health has delivered an annual health literacy demonstration training course that it developed. Course development and delivery partners included HealthWest Partnership and cohealth. The courses are designed to develop the health literacy knowledge, skills and organisational capacity of the health and community services sector in the western metropolitan region of Melbourne. This study presents key learnings from evaluation data from three health literacy courses using Wenger's professional educational learning design framework. The framework has three educational learning architecture components (engagement, imagination and alignment) and four educational learning architecture dimensions (participation, emergent, local/global, identification). Participatory realist evaluation approaches and qualitative methods were used. The evaluations revealed that the health literacy courses are developing leadership in health literacy, building partnerships among course participants, developing health literacy workforce knowledge and skills, developing ways to use and apply health literacy resources and are serving as a catalyst for building organisational infrastructure. Although the courses were not explicitly developed or implemented using Wenger's educational learning design pedagogic features, the course structure (i.e. facilitation role of course coordinators, providing safe learning environments, encouraging small group work amongst participants, requiring participants to conduct mini-projects and sponsor organisation buy-in) provided opportunities for engagement, imagination and alignment. Wenger's educational learning design framework can inform the design of future key

  7. Topics from Australian Conferences on Teaching Statistics

    CERN Document Server

    Phillips, Brian; Martin, Michael

    2014-01-01

    The first OZCOTS conference in 1998 was inspired by papers contributed by Australians to the 5th International Conference on Teaching Statistics. In 2008, as part of the program of one of the first National Senior Teaching Fellowships, the 6th OZCOTS was held in conjunction with the Australian Statistical Conference, with Fellowship keynotes and contributed papers, optional refereeing and proceedings. This venture was so successful that the 7th and 8th OZCOTS were similarly run, conjoined with Australian Statistical Conferences in 2010 and 2012. Authors of papers from these OZCOTS conferences were invited to develop chapters for refereeing and inclusion in this volume. There are sections on keynote topics, undergraduate curriculum and learning, professional development, postgraduate learning, and papers from OZCOTS 2012. Because OZCOTS aim to unite statisticians and statistics educators, the approaches this volume takes are immediately relevant to all who have a vested interest in good teaching practices. Glo...

  8. Topics on electricity trade

    Energy Technology Data Exchange (ETDEWEB)

    Skytte, K.

    2001-07-01

    being unable to fulfil the commitments made on the spot market. The disclosed cost of using the regulating power market is a quadratic function of the amount of regulation. This asymmetric cost may encourage bidders with fluctuating production to be more strategic in their way of bidding on the spot market. By using such strategies the extra costs (for e.g. wind power) needed to counter unpredictable fluctuations may be limited. The fourth paper applies the findings in the previous paper to show how a supplier with a 'controllable' production will make strategic bids on the power exchange - in this case a heat pump. The fifth paper discusses the design of the regulating power market and what the choice of design means for suppliers with fluctuating production, e.g. wind turbines. It is found that not only does the accuracy of the wind prediction influence the use of the power exchange, but the structure of the power exchange itself may also play an important role. Several studies of the northern European electricity liberalisation have concluded that developments of a liberalised electricity market and cross border trade can be of benefit for the consumers and bring along a global environmental improvement. All these studies have assumed that a perfect competitive electricity market can be obtained. A number of imperfections, which inevitably will arise, have not been taken into account, - at least in the transition period. These imperfections can be technical, economic or tradition-bound, but may have political characteristics as well. The sixth paper in this thesis surveys those market imperfections which are most likely to appear. Market imperfections can, for example, have structural or political characteristics that imply non-optimal competitive behaviour, e.g., the means to achieve political goals may hinder the desirable effects of the liberalisation. This can, for example, come from the creation of suitable arrangements for survival and enlargement of

  9. Topic structure for information retrieval

    NARCIS (Netherlands)

    He, J.; Sanderson, M.; Zhai, C.; Zobel, J.; Allan, J.; Aslam, J.A.

    2009-01-01

    In my research, I propose a coherence measure, with the goal of discovering and using topic structures within and between documents, of which I explore its extensions and applications in information retrieval.

  10. Lattice quantum chromodynamics: Some topics

    Indian Academy of Sciences (India)

    Abstract. I review some topics in lattice quantum chromodynamics, focusing more on the recent results. These include: the QCD phase diagram in the - plane,; the quark number susceptibilities, and; the screening lengths.

  11. Erythromycin and Benzoyl Peroxide Topical

    Science.gov (United States)

    The combination of erythromycin and benzoyl peroxide is used to treat acne. Erythromycin and benzoyl peroxide are in a class of medications called topical antibiotics. The combination of erythromycin and benzoyl peroxide works by killing the bacteria ...

  12. Conversational topics in transsexual persons.

    Science.gov (United States)

    Van Borsel, John; Cayzeele, Miet; Heirman, Eva; T'sjoen, Guy

    2014-06-01

    Abstract In general, speech language therapy for transsexual persons focuses on pitch and pitch variation and more recently also on resonance. Other communicative aspects are dealt with far less often, especially language. This study investigated to what extent conversational topics might need attention in therapy for transsexual persons. A total of 111 males, 116 females, 28 male-to-female and 18 female-to-male transsexuals were asked to indicate on a list with 34 topics how often they speak about each topic (never, sometimes, often) in conversations with males, with females and in a gender mixed group. Results showed that transsexual persons behave in accordance with the desired gender. However, they also tend to adopt a position depending on the gender of their conversational partner. It can be concluded that in general it is not necessary to pay attention to conversational topics in therapy for transsexual persons.

  13. Safety and Health Topics: Asbestos

    Science.gov (United States)

    ... Videos E-Tools Safety and Health Topics / Asbestos Asbestos This page requires that javascript be enabled for ... Hazards and Toxic Substances Hazardous Waste What is asbestos? Asbestos is the name given to a group ...

  14. Topics in Theoretical Physics

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Andrew [Boston Univ., MA (United States); Schmaltz, Martin [Boston Univ., MA (United States); Katz, Emmanuel [Boston Univ., MA (United States); Rebbi, Claudio [Boston Univ., MA (United States); Glashow, Sheldon [Boston Univ., MA (United States); Brower, Richard [Boston Univ., MA (United States); Pi, So-Young [Boston Univ., MA (United States)

    2016-09-30

    This award supported a broadly based research effort in theoretical particle physics, including research aimed at uncovering the laws of nature at short (subatomic) and long (cosmological) distances. These theoretical developments apply to experiments in laboratories such as CERN, the facility that operates the Large Hadron Collider outside Geneva, as well as to cosmological investigations done using telescopes and satellites. The results reported here apply to physics beyond the so-called Standard Model of particle physics; physics of high energy collisions such as those observed at the Large Hadron Collider; theoretical and mathematical tools and frameworks for describing the laws of nature at short distances; cosmology and astrophysics; and analytic and computational methods to solve theories of short distance physics. Some specific research accomplishments include + Theories of the electroweak interactions, the forces that give rise to many forms of radioactive decay; + Physics of the recently discovered Higgs boson. + Models and phenomenology of dark matter, the mysterious component of the universe, that has so far been detected only by its gravitational effects. + High energy particles in astrophysics and cosmology. + Algorithmic research and Computational methods for physics of and beyond the Standard Model. + Theory and applications of relativity and its possible limitations. + Topological effects in field theory and cosmology. + Conformally invariant systems and AdS/CFT. This award also supported significant training of students and postdoctoral fellows to lead the research effort in particle theory for the coming decades. These students and fellows worked closely with other members of the group as well as theoretical and experimental colleagues throughout the physics community. Many of the research projects funded by this grant arose in response to recently obtained experimental results in the areas of particle physics and cosmology. We describe a few of

  15. KEY TOPICS IN SPORTS MEDICINE

    OpenAIRE

    Amir Ali Narvani; Panagiotis Thomas; Burce Lynn

    2006-01-01

    Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

  16. Topics in modern differential geometry

    CERN Document Server

    Verstraelen, Leopold

    2017-01-01

    A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

  17. Topics of Bioengineering in Wikipedia

    Directory of Open Access Journals (Sweden)

    Vassia Atanassova

    2009-10-01

    Full Text Available The present report aims to give a snapshot of how topics from the field of bioengineering (bioinformatics, bioprocess systems, biomedical engineering, biotechnology, etc. are currently covered in the free electronic encyclopedia Wikipedia. It also offers insights and information about what Wikipedia is, how it functions, how and when to cite Wikipedian articles, if necessary. Several external wikis, devoted to topics of bioengineering, are also listed and reviewed.

  18. Being Professional

    DEFF Research Database (Denmark)

    Jensen, Anne Winther

    The paper discusses students' process of acquiring a feeling of being professionals within a vocational education programme for elderly care in Denmark. The focus is on what seems to be a paradox within the programme: the future care helper being constructed within the overall term ‘the professio......The paper discusses students' process of acquiring a feeling of being professionals within a vocational education programme for elderly care in Denmark. The focus is on what seems to be a paradox within the programme: the future care helper being constructed within the overall term ‘the...... professional care helper’ in the school setting but the job being closely related to daily life's routine tasks; the paper points to difficulties for students in identifying the exact content of the term ‘professional’. Furthermore students seem to be uncertain about their ‘professionalism’ in relation...... ‘storyline’, c.f. Bronwyn Davies and the empirical material consists of observations and interviews in the theoretical periods and in the traineeships....

  19. Selected topics of fluid mechanics

    Science.gov (United States)

    Kindsvater, Carl E.

    1958-01-01

    The fundamental equations of fluid mechanics are specific expressions of the principles of motion which are ascribed to Isaac Newton. Thus, the equations which form the framework of applied fluid mechanics or hydraulics are, in addition to the equation of continuity, the Newtonian equations of energy and momentum. These basic relationships are also the foundations of river hydraulics. The fundamental equations are developed in this report with sufficient rigor to support critical examinations of their applicability to most problems met by hydraulic engineers of the Water Resources Division of the United States Geological Survey. Physical concepts are emphasized, and mathematical procedures are the simplest consistent with the specific requirements of the derivations. In lieu of numerical examples, analogies, and alternative procedures, this treatment stresses a brief methodical exposition of the essential principles. An important objective of this report is to prepare the user to read the literature of the science. Thus, it begins With a basic vocabulary of technical symbols, terms, and concepts. Throughout, emphasis is placed on the language of modern fluid mechanics as it pertains to hydraulic engineering. The basic differential and integral equations of simple fluid motion are derived, and these equations are, in turn, used to describe the essential characteristics of hydrostatics and piezometry. The one-dimensional equations of continuity and motion are defined and are used to derive the general discharge equation. The flow net is described as a means of demonstrating significant characteristics of two-dimensional irrotational flow patterns. A typical flow net is examined in detail. The influence of fluid viscosity is described as an obstacle to the derivation of general, integral equations of motion. It is observed that the part played by viscosity is one which is usually dependent on experimental evaluation. It follows that the dimensionless ratios known as

  20. Use of topical corticosteroids on chronic leg ulcers.

    Science.gov (United States)

    Hofman, D; Moore, K; Cooper, R; Eagle, M; Cooper, S

    2007-05-01

    Topical corticosteroids are widely used in the management of chronic wounds, yet there is little evidence to support this. This pilot study aimed to identify current practice by three specialist nurses and to assess the efficacy of topical corticosteroids. Data on healing, pain relief, exudate reduction and control of hypergranulation tissue were collected on 34 patients whose wounds were treated with topical corticosteroids prospectively in three centres over a three-month period. Twenty-seven patients (79%) benefited from the application of topical corticosteroid either in terms of healing, pain relief, exudate reduction or the control of hypergranulation tissue. Two wounds deteriorated and treatment was immediately withdrawn. Suppression of inflammation plays an important role in healing and pain relief. Applying topical corticosteroids to the wound can accelerate healing and reduce pain in certain cases. However, careful monitoring is essential as there is a risk of sensitisation with prolonged use as well as a potential increased risk of infection.

  1. Topics in multivariate approximation and interpolation

    CERN Document Server

    Jetter, Kurt

    2005-01-01

    This book is a collection of eleven articles, written by leading experts and dealing with special topics in Multivariate Approximation and Interpolation. The material discussed here has far-reaching applications in many areas of Applied Mathematics, such as in Computer Aided Geometric Design, in Mathematical Modelling, in Signal and Image Processing and in Machine Learning, to mention a few. The book aims at giving a comprehensive information leading the reader from the fundamental notions and results of each field to the forefront of research. It is an ideal and up-to-date introduction for gr

  2. Mining nonterrestrial resources: Information needs and research topics

    Science.gov (United States)

    Daemen, Jaak J. K.

    1992-01-01

    An outline of topics we need to understand better in order to apply mining technology to a nonterrestrial environment is presented. The proposed list is not intended to be complete. It aims to identify representative topics that suggest productive research. Such research will reduce the uncertainties associated with extrapolating from conventional earthbound practice to nonterrestrial applications. One objective is to propose projects that should put future discussions of nonterrestrial mining on a firmer, less speculative basis.

  3. Assessing the Scope and Feasibility of First-Year Students' Research Paper Topics

    Science.gov (United States)

    Rinto, Erin; Bowles-Terry, Melissa; Santos, Ariel J.

    2016-01-01

    This study applied a content analysis methodology in two ways to evaluate first-year students' research topics: a rubric to examine proposed topics in terms of scope, development, and the "researchability" of the topic, as well as textual analysis, using ATLAS.ti, to provide an overview of the types of subjects students select for a…

  4. Applied partial differential equations

    CERN Document Server

    Logan, J David

    2015-01-01

    This text presents the standard material usually covered in a one-semester, undergraduate course on boundary value problems and PDEs.  Emphasis is placed on motivation, concepts, methods, and interpretation, rather than on formal theory. The concise treatment of the subject is maintained in this third edition covering all the major ideas: the wave equation, the diffusion equation, the Laplace equation, and the advection equation on bounded and unbounded domains. Methods include eigenfunction expansions, integral transforms, and characteristics. In this third edition, text remains intimately tied to applications in heat transfer, wave motion, biological systems, and a variety other topics in pure and applied science. The text offers flexibility to instructors who, for example, may wish to insert topics from biology or numerical methods at any time in the course. The exposition is presented in a friendly, easy-to-read, style, with mathematical ideas motivated from physical problems. Many exercises and worked e...

  5. Principles of topical treatment: advancement in gel vehicle technology.

    Science.gov (United States)

    Feldman, Steven R

    2014-04-01

    Topical treatment is a pillar of dermatologic practice. The delivery of drug by a topical vehicle is dependent on complex physical chemistry and on how well patients apply the product. The potency of topical agents is not solely dependent on the concentration of active drug in the vehicle. A corticosteroid molecule may have vastly different potency depending on what vehicle is used to deliver it. Similarly, a new gel vehicle is able to deliver considerably more active antifungal than an older vehicle technology and may represent a promising vehicle for other novel formulations. The use of new vehicles can provide more effective means for treating patients with skin disease.

  6. TOPIC DECONGESTANTS IN COMPLEX THERAPY OF UPPER AIRWAYS DISEASES

    Directory of Open Access Journals (Sweden)

    G.D. Tarasova

    2006-01-01

    Full Text Available In the complex treatment of the inflammatory diseases of ENT-organs (rhinitis, sinusitis, tubootitis and otitis media vasoconstrictors (topic decongestants are locally applied. Besides, they're used in diagnosing of nasal cavity diseases. Topic decongestants are produced as nasal drops and nasal sprays. Peculiarities of application of pharmaceuticals in children are dependent on inherent properties, particularly the duration of effect. These drugs each have proper dosage conditions that should be followed carefully in pediatric practice. Moreover, the physician must choose the efficient way of vasoconstrictor introduction into nasal cavity.Key words: edema, topic decongestants, ENT-organs diseases, rebound syndrome, children.

  7. Application of Topic Map on Knowledge Organization

    Directory of Open Access Journals (Sweden)

    Sou-shan Wu

    2003-06-01

    Full Text Available Knowledge management (KM has received much attention from both academics and practitioners in the past few years. Following the KM trend, many organizations have built their own knowledge repositories or data warehouses. However, information or knowledge is still scattered everywhere without being properly managed. The rapid growth of the Internet accelerates the creation of unstructured and unclassified information and causes the explosion of information overload. The effort of browsing information through general-purpose search engines turns out to be tedious and painstaking. Hence, an effective technology to solve this information retrieval problem is much needed. The purpose of this research is to explore the application of text mining technique in organizing knowledge stored in unstructured natural language text documents. Major components of text mining techniques required for topic map in particular will be presented in detail.Two sets of unstructured documents are utilized to demonstrate the usage of SOM for topic categorization. The first set of documents is a collection of speeches given by Y.C. Wang, Chairman of the Taiwan Plastics Group, and the other is the collection of all laws and regulations related to securities and future markets in Taiwan. We also try to apply text mining to these two sets of documents to generate their respective topic maps, thus revealing the differences between organizing explicit and tacit knowledge as well as the difficulties associated with tacit knowledge.[Article content in Chinese

  8. Professionals' views on mental health service users' education: challenges and support.

    Science.gov (United States)

    Nieminen, I; Kaunonen, M

    2017-02-01

    WHAT IS KNOWN ON THE SUBJECT?: Mental health service users (MHSUs) may experience disruptions in their education. However, education has been shown to have a positive influence on their recovery, potentially offering them broader employment opportunities. The literature suggests that providing support for MHSUs in their educational efforts may be beneficial and is wished for by the service users themselves. However, there is a lack of mental health professionals' views on the topic in the setting of a community mental health centre. WHAT DOES THIS PAPER ADD TO THE EXISTING KNOWLEDGE?: In the perception of mental health professionals, the predominance of disease in the life of MHSUs and their marginalization may form barriers to their success in education. Professionals can support MHSUs in their educational efforts by strengthening the MHSUs' internal resources and creating a supportive environment with professional expertise available. A service user-centred education might further help MHSUs to achieve their educational goals. Our findings confirm previous knowledge of a recovery-oriented approach to supporting MHSUs' education. This study explored the topic from the professionals' perspective in the context of community mental health centres, which is a fresh view in the research literature. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: The findings suggest which types of support professionals perceive to be required for MHSUs to advance their studies. Knowledge of adequate forms of support can be applied in the mental health nursing practice to develop support measures for service users to advance in their studies. All levels of the community mental health centres should be aware of and adopt a recovery-oriented approach. MHSUs and professionals need to have a shared opinion on the definition of recovery orientation. This requires mutual discussion and the more active involvement of MHSUs in the design of their own rehabilitation process. Introduction Studies show

  9. Systematic review of topic treatment for venous ulcers

    OpenAIRE

    Borges, Eline Lima; Caliri, Maria Helena Larcher; Haas, Vanderlei José

    2007-01-01

    Venous ulcer patients can experience this situation for several years without achieving healing if treatment is inadequate. Evidence-based professional practice generates effective results for patients and services. This research aimed to carry out a systematic review to assess the most effective method to improve venous return and the best topic treatment for these ulcers. Studies were collected in eight databases, using the following descriptors: leg ulcer, venous ulcer and similar terms. T...

  10. Professional development

    Science.gov (United States)

    Yoon, Jin Hee; Hartline, Beverly Karplus; Milner-Bolotin, Marina

    2013-03-01

    The three sessions of the professional development workshop series were each designed for a different audience. The purpose of the first session was to help mid-career physicists aspire for and achieve leadership roles. The second session brought together students, postdoctoral fellows, and early-career physicists to help them plan their career goals and navigate the steps important to launching a successful career. The final session sought to increase awareness of the results of physics education research, and how to use them to help students-especially women-learn physics better. The presentations and discussions were valuable for both female and male physicists.

  11. Professional C++

    CERN Document Server

    Gregoire, Marc

    2014-01-01

    Master complex C++ programming with this helpful, in-depth resource From game programming to major commercial software applications, C++ is the language of choice. It is also one of the most difficult programming languages to master. While most competing books are geared toward beginners, Professional C++, Third Edition, shows experienced developers how to master the latest release of C++, explaining little known features with detailed code examples users can plug into their own codes. More advanced language features and programming techniques are presented in this newest edition of the book,

  12. Topical corticosteroids: Abuse and Misuse

    Directory of Open Access Journals (Sweden)

    Yugandar Inakanti

    2015-04-01

    Full Text Available Background: The Topical Corticosteroids are among the most commonly prescribed medication in an out-patient dermatology setting since they were first introduced in early 1950s. Probably no other group of drugs has had such a profound impact on the specialty as Topical Corticosteroid. They provide rapid symptomatic relief in almost all inflammatory dermatoses, especially in the short term. Multiple pathways including rebound vasodilatation and proinflammatory cytokine release have been proposed as the mechanism for such reactions. Aim: To study various adverse effects of topical corticosteroids misuse over face. Materials and Methods: 130 patients with a history of topical corticosteroid use on face for minimum 1 month duration were included in this study. Results: Majority of patients were between age group of 21 to 30 (65.4%. Female sex preponderance over male sex with 67.8%. Majority of patients were House wives (49% followed by Employees (23%. Duration of application of TC was 3-6 months (77% in majority of cases. Most commonly abused TC was Betamethasone Valerate (79.2%. Conclusion: Topical Corticosteroid should not be used on the face unless it is under strict dermatological supervision.

  13. Deep Unfolding for Topic Models.

    Science.gov (United States)

    Chien, Jen-Tzung; Lee, Chao-Hsi

    2018-02-01

    Deep unfolding provides an approach to integrate the probabilistic generative models and the deterministic neural networks. Such an approach is benefited by deep representation, easy interpretation, flexible learning and stochastic modeling. This study develops the unsupervised and supervised learning of deep unfolded topic models for document representation and classification. Conventionally, the unsupervised and supervised topic models are inferred via the variational inference algorithm where the model parameters are estimated by maximizing the lower bound of logarithm of marginal likelihood using input documents without and with class labels, respectively. The representation capability or classification accuracy is constrained by the variational lower bound and the tied model parameters across inference procedure. This paper aims to relax these constraints by directly maximizing the end performance criterion and continuously untying the parameters in learning process via deep unfolding inference (DUI). The inference procedure is treated as the layer-wise learning in a deep neural network. The end performance is iteratively improved by using the estimated topic parameters according to the exponentiated updates. Deep learning of topic models is therefore implemented through a back-propagation procedure. Experimental results show the merits of DUI with increasing number of layers compared with variational inference in unsupervised as well as supervised topic models.

  14. Applied Macroeconomics

    NARCIS (Netherlands)

    Heijman, W.J.M.

    2000-01-01

    This book contains a course in applied macroeconomics. Macroeconomic theory is applied to real world cases. Students are expected to compute model results with the help of a spreadsheet program. To that end the book also contains descriptions of the spreadsheet applications used, such as linear

  15. A blended-learning programme regarding professional ethics in physiotherapy students.

    Science.gov (United States)

    Aguilar-Rodríguez, Marta; Marques-Sule, Elena; Serra-Añó, Pilar; Espí-López, Gemma Victoria; Dueñas-Moscardó, Lirios; Pérez-Alenda, Sofía

    2018-01-01

    In the university context, assessing students' attitude, knowledge and opinions when applying an innovative methodological approach to teach professional ethics becomes fundamental to know if the used approach is enough motivating for students. To assess the effect of a blended-learning model, based on professional ethics and related to clinical practices, on physiotherapy students' attitude, knowledge and opinions towards learning professional ethics. Research design and participants: A simple-blind clinical trial was performed (NLM identifier NCT03241693) (control group, n = 64; experimental group, n = 65). Both groups followed clinical practices for 8 months. Control group performed a public exposition of a clinical case about professional ethics. By contrast, an 8-month blended-learning programme regarding professional ethics was worked out for experimental group. An online syllabus and online activities were elaborated, while face-to-face active participation techniques were performed to discuss ethical issues. Students' attitudes, knowledge and opinions towards learning professional ethics were assessed. Ethical considerations: The study was approved by the University Ethic Committee of Human Research and followed the ethical principles according to the Declaration of Helsinki. After the programme, attitudes and knowledge towards learning professional ethics of experimental group students significantly improved, while no differences were observed in control group. Moreover, opinions reported an adequate extension of themes and temporization, importance of clinical practices and interest of topics. Case study method and role playing were considered as the most helpful techniques. The blended-learning programme proposed, based on professional ethics and related to clinical practices, improves physiotherapy students' attitudes, knowledge and opinions towards learning professional ethics.

  16. Topical corticosteroid addiction and phobia

    Directory of Open Access Journals (Sweden)

    Aparajita Ghosh

    2014-01-01

    Full Text Available Corticosteroids, one of the most widely prescribed topical drugs, have been used for about six decades till date. However, rampant misuse and abuse down the years has given the drug a bad name. Topical steroid abuse may lead to two major problems which lie at the opposing ends of the psychosomatic spectrum. Topical steroid addiction, a phenomenon that came to be recognized about a decade after the introduction of the molecule is manifested as psychological distress and rebound phenomenon on stoppage of the drug. The rebound phenomenon, which can affect various parts of the body particularly the face and the genitalia has been reported by various names in the literature. TC phobia which lies at the opposite end of the psychiatric spectrum of steroid abuse has been reported particularly among parents of atopic children. Management of both conditions is difficult and frustrating. Psychological counseling and support can be of immense help in both the conditions.

  17. Quantum mechanics II advanced topics

    CERN Document Server

    Rajasekar, S

    2015-01-01

    Quantum Mechanics II: Advanced Topics uses more than a decade of research and the authors’ own teaching experience to expound on some of the more advanced topics and current research in quantum mechanics. A follow-up to the authors introductory book Quantum Mechanics I: The Fundamentals, this book begins with a chapter on quantum field theory, and goes on to present basic principles, key features, and applications. It outlines recent quantum technologies and phenomena, and introduces growing topics of interest in quantum mechanics. The authors describe promising applications that include ghost imaging, detection of weak amplitude objects, entangled two-photon microscopy, detection of small displacements, lithography, metrology, and teleportation of optical images. They also present worked-out examples and provide numerous problems at the end of each chapter.

  18. Topical application of hemostatic paste

    Directory of Open Access Journals (Sweden)

    Mohammad Mizanur Rahman

    2017-02-01

    Full Text Available As a measure to control minor surgical bleeding, surgeons usually depend on a number of hemostatic aids. Topical use of bovine thrombin is a widely used procedure to arrest such minor bleeding. A 35 year old male sergeant of Bangladesh Air Force presented with repeated development of hematoma in his left thigh without any history of trauma or previous history of bleeding. Critical analysis of the patient’s history, routine and sophisticated hematological investigations revealed that the patient developed anti-thrombin antibody following the application of hemostatic paste in the tooth socket five years back during minor dental procedure to stop ignorable bleeding episodes. Therefore, topical use of hemostatic glue/paste or bovine thrombin should be avoided to desist minor bleeding as recombinant human thrombin is now available for topical use.

  19. Pharmacovigilance: Empowering healthcare professionals

    Directory of Open Access Journals (Sweden)

    Mugoša Snežana S.

    2015-01-01

    Full Text Available Introduction: Spontaneous reporting of adverse reactions is of greatest importance for obtaining information about adverse drug reactions (ADRs after granting the marketing authorization. The most important role and also the greatest responsibility belong to healthcare professionals. Their active participation is a prerequisite for the existence of an effective national drug safety monitoring. Methods: This paper examines the legislative framework concerning the pharmacovigilance system in Montenegro. The information was collected from scientific articles and the website of the Agency for Medicines and Medical Devices of Montenegro. Topic: Key segments of pharmacovigilance system are presented, with a special reference to the importance of spontaneous reporting of ADRs, results of spontaneous reporting of ADRs according to the latest Agency's Annual report on the results of spontaneous reporting of adverse reactions to medicines, possible reasons for underreporting ADRs, as well as the new EU regulation on pharmacovigilance. Conclusions: Spontaneous reporting of ADRs remains the cornerstone of pharmacovigilance systems. Hence, continuous education of healthcare professionals is needed, with the aim of improving their awareness of the importance of ADRs and risk factors that lead to them, in order to reduce the incidence of ADRs and to increase the number of reported suspected ADRs.

  20. Safety of topical corticosteroids in pregnancy.

    Science.gov (United States)

    Chi, Ching-Chi; Wang, Shu-Hui; Wojnarowska, Fenella; Kirtschig, Gudula; Davies, Emily; Bennett, Cathy

    2015-10-26

    Topical corticosteroids are the most frequently prescribed dermatological treatment and are often used by pregnant women with skin conditions. However, little is known about their safety in pregnancy. To assess the effects of topical corticosteroids on pregnancy outcomes in pregnant women. This is an update of a review previously published in 2009. We updated our searches of the following databases to July 2015: the Cochrane Skin Group Specialised Register, the Cochrane Pregnancy and Childbirth Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2015, Issue 6), MEDLINE, EMBASE, and LILACS. We also searched five trials registers and checked the reference lists of included studies, published reviews, articles that had cited the included studies, and one author's literature collection, for further references to relevant RCTs. Randomised controlled trials and cohort studies of topical corticosteroids in pregnant women, as well as case-control studies comparing maternal exposure to topical corticosteroids between cases and controls when studies reported pre-specified outcomes. The primary outcomes included mode of delivery, major congenital abnormality, birth weight, and preterm delivery (delivery before 37 completed weeks gestation); the secondary outcomes included foetal death, minor congenital abnormality, and low Apgar score (less than seven at 5 min). We used standard methodological procedures expected by Cochrane. Two authors independently applied selection criteria, extracted data, and assessed the quality of the included studies. A third author was available for resolving differences of opinion. A further author independently extracted data from included studies that were conducted by authors of this systematic review. We included 7 new observational studies in this update, bringing the total number to 14, including 5 cohort and 9 case-control studies, with 1,601,515 study subjects.Most studies found no causal associations

  1. Topical corticosteroids in dental practice.

    Science.gov (United States)

    Savage, N W; McCullough, M J

    2005-12-01

    Topical corticosteroids represent an important therapeutic aid in the management of a range of oral mucosal disease conditions. Like all medications, their successful use depends upon an understanding of the disease process. This includes an appropriate diagnosis, a clear view of the desirable treatment outcomes and knowledge of whether treatment is aimed at management of a chronic disease or enhanced resolution of a short-term condition. This paper reviews the use of topical corticosteroids and their possible roles in the management of oral disease.

  2. Topics in millimeter wave technology

    CERN Document Server

    Button, Kenneth

    1988-01-01

    Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

  3. Topics in current aerosol research

    CERN Document Server

    Hidy, G M

    1971-01-01

    Topics in Current Aerosol Research deals with the fundamental aspects of aerosol science, with emphasis on experiment and theory describing highly dispersed aerosols (HDAs) as well as the dynamics of charged suspensions. Topics covered range from the basic properties of HDAs to their formation and methods of generation; sources of electric charges; interactions between fluid and aerosol particles; and one-dimensional motion of charged cloud of particles. This volume is comprised of 13 chapters and begins with an introduction to the basic properties of HDAs, followed by a discussion on the form

  4. Rosacea and its topical management.

    Science.gov (United States)

    Gooderham, M

    2009-02-01

    Many options exist for the treatment of rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures. A classification system for rosacea identifies 4 subtypes (i.e., erythematotelangiectatic, papulopustular, phymatous, and ocular), which may help guide therapeutic decision-making. The goals of therapy include reduction of papules, pustules, erythema, physical discomfort, and an improvement in quality of life. Standard topical treatment agents include metronidazole, azelaic acid, and sodium sulfacetamide-sulfur. Second line therapies include benzoyl peroxide, clindamycin, calcineurin inhibitors, and permethrin.

  5. Ethics Education for Professionals in Japan: A Critical Review

    Science.gov (United States)

    Maruyama, Yasushi; Ueno, Tetsu

    2010-01-01

    Ethics education for professionals has become popular in Japan over the last two decades. Many professional schools now require students to take an applied ethics or professional ethics course. In contrast, very few courses of professional ethics for teaching exist or have been taught in Japan. In order to obtain suggestions for teacher education,…

  6. Teaching professionalism in science courses: anatomy to zoology.

    Science.gov (United States)

    Macpherson, Cheryl C

    2012-02-01

    Medical professionalism is reflected in attitudes, behaviors, character, and standards of practice. It is embodied by physicians who fulfill their duties to patients and uphold societies' trust in medicine. Professionalism requires familiarity with the ethical codes and standards established by international, governmental, institutional, or professional organizations. It also requires becoming aware of and responsive to societal controversies. Scientific uncertainty may be used to teach aspects of professionalism in science courses. Uncertainty about the science behind, and the health impacts of, climate change is one example explored herein that may be used to teach both professionalism and science. Many medical curricula provide students with information about professionalism and create opportunities for students to reflect upon and strengthen their individually evolving levels of professionalism. Faculties in basic sciences are rarely called upon to teach professionalism or deepen medical students understanding of professional standards, competencies, and ethical codes. However they have the knowledge and experience to develop goals, learning objectives, and topics relevant to professionalism within their own disciplines and medical curricula. Their dedication to, and passion for, science will support basic science faculties in designing innovative and effective approaches to teaching professionalism. This paper explores topics and formats that scientists may find useful in teaching professional attitudes, skills, and competencies in their medical curriculum. It highlights goals and learning objectives associated with teaching medical professionalism in the basic sciences. Copyright © 2011. Published by Elsevier B.V.

  7. Teaching professionalism in science courses: Anatomy to zoology

    Directory of Open Access Journals (Sweden)

    Cheryl C. Macpherson

    2012-02-01

    Full Text Available Medical professionalism is reflected in attitudes, behaviors, character, and standards of practice. It is embodied by physicians who fulfill their duties to patients and uphold societies’ trust in medicine. Professionalism requires familiarity with the ethical codes and standards established by international, governmental, institutional, or professional organizations. It also requires becoming aware of and responsive to societal controversies. Scientific uncertainty may be used to teach aspects of professionalism in science courses. Uncertainty about the science behind, and the health impacts of, climate change is one example explored herein that may be used to teach both professionalism and science. Many medical curricula provide students with information about professionalism and create opportunities for students to reflect upon and strengthen their individually evolving levels of professionalism. Faculties in basic sciences are rarely called upon to teach professionalism or deepen medical students understanding of professional standards, competencies, and ethical codes. However they have the knowledge and experience to develop goals, learning objectives, and topics relevant to professionalism within their own disciplines and medical curricula. Their dedication to, and passion for, science will support basic science faculties in designing innovative and effective approaches to teaching professionalism. This paper explores topics and formats that scientists may find useful in teaching professional attitudes, skills, and competencies in their medical curriculum. It highlights goals and learning objectives associated with teaching medical professionalism in the basic sciences.

  8. Professional socialisation: an influence on professional ...

    African Journals Online (AJOL)

    Professional socialisation refers to the acquisition of values, attitudes, skills and knowledge pertaining to a profession. This article reviews the definition and conceptualisation of professional socialisation through anticipatory and formal professional socialisation processes. It describes the core elements of professional ...

  9. Langley's DEVELOP Team Applies NASA's Earth Observations to Address Environmental Issues Across the Country and Around the Globe

    Science.gov (United States)

    Childs, Lauren M.; Miller, Joseph E.

    2011-01-01

    The DEVELOP National Program was established over a decade ago to provide students with experience in the practical application of NASA Earth science research results. As part of NASA's Applied Sciences Program, DEVELOP focuses on bridging the gap between NASA technology and the public through projects that innovatively use NASA Earth science resources to address environmental issues. Cultivating a diverse and dynamic group of students and young professionals, the program conducts applied science research projects during three terms each year (spring, summer, and fall) that focus on topics ranging from water resource management to natural disasters.

  10. Applied superconductivity

    CERN Document Server

    Newhouse, Vernon L

    1975-01-01

    Applied Superconductivity, Volume II, is part of a two-volume series on applied superconductivity. The first volume dealt with electronic applications and radiation detection, and contains a chapter on liquid helium refrigeration. The present volume discusses magnets, electromechanical applications, accelerators, and microwave and rf devices. The book opens with a chapter on high-field superconducting magnets, covering applications and magnet design. Subsequent chapters discuss superconductive machinery such as superconductive bearings and motors; rf superconducting devices; and future prospec

  11. Applied logistic regression

    CERN Document Server

    Hosmer, David W; Sturdivant, Rodney X

    2013-01-01

     A new edition of the definitive guide to logistic regression modeling for health science and other applications This thoroughly expanded Third Edition provides an easily accessible introduction to the logistic regression (LR) model and highlights the power of this model by examining the relationship between a dichotomous outcome and a set of covariables. Applied Logistic Regression, Third Edition emphasizes applications in the health sciences and handpicks topics that best suit the use of modern statistical software. The book provides readers with state-of-

  12. Seven topics in perturbative QCD

    Energy Technology Data Exchange (ETDEWEB)

    Buras, A.J.

    1980-09-01

    The following topics of perturbative QCD are discussed: (1) deep inelastic scattering; (2) higher order corrections to e/sup +/e/sup -/ annihilation, to photon structure functions and to quarkonia decays; (3) higher order corrections to fragmentation functions and to various semi-inclusive processes; (4) higher twist contributions; (5) exclusive processes; (6) transverse momentum effects; (7) jet and photon physics.

  13. Topic Map for Authentic Travel

    OpenAIRE

    Wandsvik, Atle; Zare, Mehdi

    2007-01-01

    E-business is a new trend in Internet use. Authentic travel is an approach to travel and travel business which helps the traveler experience what is authentic in the travel destination. But how can the traveler find those small authentic spots and organize them together to compose a vacation? E-business techniques, combined withTopic Maps, can help.

  14. Constructivist Approach in a Paradigm of Public School Teachers′ Professional Development in Great Britain, Canada, the USA

    Directory of Open Access Journals (Sweden)

    Mukan Nataliya

    2017-06-01

    Full Text Available The article dwells on professional development of public school teachers as an inevitable constituent of education systems in the 21st century. In such economically developed countries as Great Britain, Canada and the USA, the problem of preparing teachers to a difficult and responsible task of upbringing and educating future citizens always remains topical. The authors define the following aim and objectives of their research: to conduct analysis of scientific and pedagogical literature and to define the notion of teachers′ “professional development”; to research a place and role of the constructivist approach to professional development of teachers. Some aspects of the problem under research have been studied by foreign and domestic scientists: political, social, cultural and economic aspects of teachers′ professional development (L. Darling-Hammond, M. Tight; elaboration of professional development curricula (C. Pratt; content of teachers′ professional development (N. Dana Fichtman, S. Zepeda; concept-oriented instruction (J. Guthrie; continuing professional development (Ya. Belmaz, A. Kuzminskyi, O. Kuznietsova. The research methodology comprises theoretical (logical, structural and systematic methods, induction and deduction, comparison and compatibility, analysis and synthesis and applied (observations, questioning and interviewing methods. The research results have been presented.

  15. Topical Antimycotics for Oral Candidiasis in Warfarin Users

    DEFF Research Database (Denmark)

    Hellfritzsch, Maja; Pottegård, Anton; Pedersen, Andreas James Thestrup

    2017-01-01

    Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study with the obj......Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study...... for oral candidiasis....

  16. Health professionals' quality of life in relation to end of life care.

    Science.gov (United States)

    Linzitto, Juan P; Grance, Gladys

    2017-12-01

    Palliative care professionals are frequently exposed to stressful and demanding situations in the assistance of patients and their families, therefore research related to their quality of life is a relevant topic to provide evidence on interventions oriented to professional self-care. Research about professionals' quality of life is having a profuse development with core concepts being under review. Currently, burnout syndrome and compassion fatigue are considered relevant determinants of professionals' quality of life. Self-awareness-based interventions could bring positive influence on the context of a multidimensional approach to professionals' self-care. Self-care topics should be considered to be included in professional training programmes.

  17. Experienced Teacher Educators and their Professional Learning.

    NARCIS (Netherlands)

    dr Marcel van der Klink; dr.ir. Quinta Kools; dr Simone White

    2010-01-01

    The professional development of teacher educators is increasingly being recognised as a topic of paramount importance. This is partly caused by the stronger emphasis on improving the quality of teacher education programs and as a consequence on attention for the lifelong learning of those

  18. Outcomes of a Chemistry Content Professional Learning Session: Teachers' Perspectives

    Science.gov (United States)

    Rowen, Catherine; Woods-McConney, Amanda; Hughes, Leonie; Laird, Damian

    2017-01-01

    The national curriculum for chemistry includes topics that have not previously been taught at secondary level. In response to requests for teacher professional learning (PL) covering these topics, a course called "Divide and Analyse" was developed. Investigations into the PL needs of chemistry teachers were carried out in conjunction…

  19. Applying statistics in behavioural research

    NARCIS (Netherlands)

    Ellis, J.L.

    2016-01-01

    Applying Statistics in Behavioural Research is written for undergraduate students in the behavioural sciences, such as Psychology, Pedagogy, Sociology and Ethology. The topics range from basic techniques, like correlation and t-tests, to moderately advanced analyses, like multiple regression and

  20. Professional Enterprise NET

    CERN Document Server

    Arking, Jon

    2010-01-01

    Comprehensive coverage to help experienced .NET developers create flexible, extensible enterprise application code If you're an experienced Microsoft .NET developer, you'll find in this book a road map to the latest enterprise development methodologies. It covers the tools you will use in addition to Visual Studio, including Spring.NET and nUnit, and applies to development with ASP.NET, C#, VB, Office (VBA), and database. You will find comprehensive coverage of the tools and practices that professional .NET developers need to master in order to build enterprise more flexible, testable, and ext

  1. Professional ASPNET Design Patterns

    CERN Document Server

    Millett, Scott

    2010-01-01

    Professional ASP.NET Design Patterns will show you how to implement design patterns in real ASP.NET applications by introducing you to the basic OOP skills needed to understand and interpret design patterns. A sample application used throughout the book is an enterprise level ASP.NET website with multi-tiered, SOA design techniques that can be applied to your future ASP.NET projects. Read about each design pattern in detail, including how to interpret the UML design, how to implement it in ASP.NET, its importance for ASP.NET development, and how it's integrated into the final project.

  2. Detecting Hotspot Information Using Multi-Attribute Based Topic Model

    Science.gov (United States)

    Wang, Jing; Li, Li; Tan, Feng; Zhu, Ying; Feng, Weisi

    2015-01-01

    Microblogging as a kind of social network has become more and more important in our daily lives. Enormous amounts of information are produced and shared on a daily basis. Detecting hot topics in the mountains of information can help people get to the essential information more quickly. However, due to short and sparse features, a large number of meaningless tweets and other characteristics of microblogs, traditional topic detection methods are often ineffective in detecting hot topics. In this paper, we propose a new topic model named multi-attribute latent dirichlet allocation (MA-LDA), in which the time and hashtag attributes of microblogs are incorporated into LDA model. By introducing time attribute, MA-LDA model can decide whether a word should appear in hot topics or not. Meanwhile, compared with the traditional LDA model, applying hashtag attribute in MA-LDA model gives the core words an artificially high ranking in results meaning the expressiveness of outcomes can be improved. Empirical evaluations on real data sets demonstrate that our method is able to detect hot topics more accurately and efficiently compared with several baselines. Our method provides strong evidence of the importance of the temporal factor in extracting hot topics. PMID:26496635

  3. The dynamic interest in topics within the biomedical scientific community.

    Science.gov (United States)

    Michon, Frederic; Tummers, Mark

    2009-08-07

    The increase in the size of the scientific community created an explosion in scientific production. We have analyzed the dynamics of biomedical scientific output during 1957-2007 by applying a bibliometric analysis of the PubMed database using different keywords representing specific biomedical topics. With the assumption that increased scientific interest will result in increased scientific output, we compared the output of specific topics to that of all scientific output. This analysis resulted in three broad categories of topics; those that follow the general trend of all scientific output, those that show highly variable output, and attractive topics which are new and grow explosively. The analysis of the citation impact of the scientific output resulted in a typical longtail distribution: the majority of journals and articles are of very low impact. This distribution has remained unchanged since 1957, although the interests of scientists must have shifted in this period. We therefore analyzed the distribution of articles in top journals and lower impact journals over time for the attractive topics. Novelty is rewarded by publication in top journals. Over time more articles are published in low impact journals progressively creating the longtail distribution, signifying acceptance of the topic by the community. There can be a gap of years between novelty and acceptance. Within topics temporary novelty is created with new subtopics. In conclusion, the longtail distribution is the foundation of the scientific output of the scientific community and can be used to examine different aspects of science practice.

  4. The dynamic interest in topics within the biomedical scientific community.

    Directory of Open Access Journals (Sweden)

    Frederic Michon

    Full Text Available The increase in the size of the scientific community created an explosion in scientific production. We have analyzed the dynamics of biomedical scientific output during 1957-2007 by applying a bibliometric analysis of the PubMed database using different keywords representing specific biomedical topics. With the assumption that increased scientific interest will result in increased scientific output, we compared the output of specific topics to that of all scientific output. This analysis resulted in three broad categories of topics; those that follow the general trend of all scientific output, those that show highly variable output, and attractive topics which are new and grow explosively. The analysis of the citation impact of the scientific output resulted in a typical longtail distribution: the majority of journals and articles are of very low impact. This distribution has remained unchanged since 1957, although the interests of scientists must have shifted in this period. We therefore analyzed the distribution of articles in top journals and lower impact journals over time for the attractive topics. Novelty is rewarded by publication in top journals. Over time more articles are published in low impact journals progressively creating the longtail distribution, signifying acceptance of the topic by the community. There can be a gap of years between novelty and acceptance. Within topics temporary novelty is created with new subtopics. In conclusion, the longtail distribution is the foundation of the scientific output of the scientific community and can be used to examine different aspects of science practice.

  5. Trends in biomedical informatics: automated topic analysis of JAMIA articles.

    Science.gov (United States)

    Han, Dong; Wang, Shuang; Jiang, Chao; Jiang, Xiaoqian; Kim, Hyeon-Eui; Sun, Jimeng; Ohno-Machado, Lucila

    2015-11-01

    Biomedical Informatics is a growing interdisciplinary field in which research topics and citation trends have been evolving rapidly in recent years. To analyze these data in a fast, reproducible manner, automation of certain processes is needed. JAMIA is a "generalist" journal for biomedical informatics. Its articles reflect the wide range of topics in informatics. In this study, we retrieved Medical Subject Headings (MeSH) terms and citations of JAMIA articles published between 2009 and 2014. We use tensors (i.e., multidimensional arrays) to represent the interaction among topics, time and citations, and applied tensor decomposition to automate the analysis. The trends represented by tensors were then carefully interpreted and the results were compared with previous findings based on manual topic analysis. A list of most cited JAMIA articles, their topics, and publication trends over recent years is presented. The analyses confirmed previous studies and showed that, from 2012 to 2014, the number of articles related to MeSH terms Methods, Organization & Administration, and Algorithms increased significantly both in number of publications and citations. Citation trends varied widely by topic, with Natural Language Processing having a large number of citations in particular years, and Medical Record Systems, Computerized remaining a very popular topic in all years. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. Detecting Hotspot Information Using Multi-Attribute Based Topic Model.

    Directory of Open Access Journals (Sweden)

    Jing Wang

    Full Text Available Microblogging as a kind of social network has become more and more important in our daily lives. Enormous amounts of information are produced and shared on a daily basis. Detecting hot topics in the mountains of information can help people get to the essential information more quickly. However, due to short and sparse features, a large number of meaningless tweets and other characteristics of microblogs, traditional topic detection methods are often ineffective in detecting hot topics. In this paper, we propose a new topic model named multi-attribute latent dirichlet allocation (MA-LDA, in which the time and hashtag attributes of microblogs are incorporated into LDA model. By introducing time attribute, MA-LDA model can decide whether a word should appear in hot topics or not. Meanwhile, compared with the traditional LDA model, applying hashtag attribute in MA-LDA model gives the core words an artificially high ranking in results meaning the expressiveness of outcomes can be improved. Empirical evaluations on real data sets demonstrate that our method is able to detect hot topics more accurately and efficiently compared with several baselines. Our method provides strong evidence of the importance of the temporal factor in extracting hot topics.

  7. Tinea Facialis Incognito: A Case Related to Topical Tacrolimus Usage

    Directory of Open Access Journals (Sweden)

    Berna Aksoy

    2011-06-01

    Full Text Available Tinea incognito is a clinical condition that is associated with topical corticosteroid and calcineurin inhibitor usage. A seventy year old male patient applied to the outpatient clinic with complaints of pruritus and erythema that began first on his forehead and spread to his whole face later and his complaints had been present for 50 days. He did not get any benefit from topical tacrolimus 0.1% ointment during the previous one month. On dermatologic examination, tinea pedis et manuum and onychomycosis were detected. Direct misroscopic examination of scrapings from erythematous papules and plaques located in the face revealed fungal elements. His lesions disappeared after systemic and topical antifungal treatment. Tinea incognito, which is usually underestimated and misdiagnosed, may develop after topical calcineurin usage and, interestingly, this disorder mimics other dermatologic diseases. In this manuscript our aim was to remind physicians of tinea incognito by presenting this case.

  8. Topical cyclosporine for atopic keratoconjunctivitis.

    Science.gov (United States)

    González-López, Julio J; López-Alcalde, Jesús; Morcillo Laiz, Rafael; Fernández Buenaga, Roberto; Rebolleda Fernández, Gema

    2012-09-12

    Atopic keratoconjunctivitis (AKC) is a chronic ocular surface non-infectious inflammatory condition that atopic dermatitis patients may suffer at any time point in the course of their dermatologic disease and is independent of its degree of severity. AKC is usually not self resolving and it poses a higher risk of corneal injuries and severe sequelae. Management of AKC should prevent or treat corneal damage. Although topical corticosteroids remain the standard treatment for patients with AKC, prolonged use may lead to complications. Topical cyclosporine A (CsA) may improve AKC signs and symptoms, and be used as a corticosteroid sparing agent. To determine the efficacy and gather evidence on safety from randomised controlled trials (RCTs) of topical CsA in patients with AKC. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 6), MEDLINE (January 1946 to July 2012), EMBASE (January 1980 to July 2012), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to July 2012), Cumulative Index to Nursing and Allied Health Literature (CINAHL) (January 1937 to July 2012), OpenGrey (System for Information on Grey Literature in Europe) (www.opengrey.eu/), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov), the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en), the IFPMA Clinical Trials Portal (http://clinicaltrials.ifpma.org/no_cache/en/myportal/index.htm) and Web of Science Conference Proceedings Citation Index- Science (CPCI-S). We did not use any date or language restrictions in the electronic searches for trials. The electronic databases were last searched on 9 July 2012. We also handsearched the following conference proceedings: American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, International Council of Opthalmology and Societas

  9. A Framework for Professional Ethics Courses in Teacher Education

    Science.gov (United States)

    Warnick, Bryan R.; Silverman, Sarah K.

    2011-01-01

    Evidence suggests that professional ethics is currently a neglected topic in teacher education programs. In this article, the authors revisit the question of ethics education for teachers. The authors propose an approach to the professional ethics of teaching that employs a case-analysis framework specifically tailored to address the practice of…

  10. Phenomenological Analysis of Professional Identity Crisis Experience by Teachers

    Science.gov (United States)

    Sadovnikova, Nadezhda O.; Sergeeva, Tamara B.; Suraeva, Maria O.

    2016-01-01

    The topicality of the problem under research is predetermined by the need of psychology and pedagogy for the study of the process of professional identity crisis experience by teachers and development of a system of measures for support of teachers' pedagogical activity and professional development. The objective of the study is to describe the…

  11. Professional Satisfaction of Teachers from Kindergarten. Preliminary Study

    Science.gov (United States)

    Anghelache, Valerica

    2014-01-01

    Professional development is a topic of great interest for all those who are involved in educational field, makers and teachers. It's approached closely related to organizational development, both representing a result of continuous changes in education. At individual level, professional development has both an internal determination (a need to…

  12. Professional Seminar in Clinical Psychology Taught from a Historical Perspective.

    Science.gov (United States)

    Harris, Ben

    1979-01-01

    Describes a ten week college level psychology seminar designed to help students take a more active role in their professional and scientific development. The first five weeks consist of tracing the historical developments in psychology; the second half focuses on contemporary topics in professional psychology. (KC)

  13. Applied impulsive mathematical models

    CERN Document Server

    Stamova, Ivanka

    2016-01-01

    Using the theory of impulsive differential equations, this book focuses on mathematical models which reflect current research in biology, population dynamics, neural networks and economics. The authors provide the basic background from the fundamental theory and give a systematic exposition of recent results related to the qualitative analysis of impulsive mathematical models. Consisting of six chapters, the book presents many applicable techniques, making them available in a single source easily accessible to researchers interested in mathematical models and their applications. Serving as a valuable reference, this text is addressed to a wide audience of professionals, including mathematicians, applied researchers and practitioners.

  14. Professional stress

    Directory of Open Access Journals (Sweden)

    Stanojević Dragana Z.

    2011-01-01

    Full Text Available Job stress is a line, for the person at work hired adverse physiological, psychological and behavioral reactions to situations in which job requirements are not in accordance with its capabilities, abilities and needs. Sources of stress at work are numerous. Personal factors: personality types have been most studied so far, environmental changes and demographic characteristics as well. Interpersonal stress inducing factors act and influence to the occurrence of many psychosomatic diseases. Psychosocial climate and relationships which are prevented or encouraged such as: cooperation and competition, trust and suspicion certainly affect to the appearance of professional stress. The way of leadership is very important. Organizational factors are the type of work, work time, noncompliance of the job, the introduction of new ethnologies, the conflict of personal roles, fear of job loss, bad physical conditions of working environment. The consequences of stress at work are numerous: at the cognitive level, the emotional level, the production plan, the health, plan reduces the immune system that cause a variety of psychosomatic illnesses and accidents at work.

  15. Retapamulin: A newer topical antibiotic

    Directory of Open Access Journals (Sweden)

    D Dhingra

    2013-01-01

    Full Text Available Impetigo is a common childhood skin infection. There are reports of increasing drug resistance to the currently used topical antibiotics including fusidic acid and mupirocin. Retapamulin is a newer topical agent of pleuromutilin class approved by the Food and Drug Administration for treatment of impetigo in children and has been recently made available in the Indian market. It has been demonstrated to have low potential for the development of antibacterial resistance and a high degree of potency against poly drug resistant Gram-positive bacteria found in skin infections including Staphylococcus aureus strains. The drug is safe owing to low systemic absorption and has only minimal side-effect of local irritation at the site of application.

  16. Ethical use of topical corticosteroids

    Directory of Open Access Journals (Sweden)

    Abir Saraswat

    2014-01-01

    Full Text Available Dermatologists rely very heavily on corticosteroids for treating many common dermatoses. Concerns about their incorrect use are widely expressed both in lay public and specialist discourse. From the point of view of medical ethics, issues of autonomy, beneficence and non-maleficence are all raised frequently when we prescribe topical corticosteroids to our patients. We need to be aware of situations when conflicts between these issues arise and have a clear thought process about resolving them. This can only be achieved if we have a thorough understanding of the skin disease being treated coupled with expertise in the use of the varied potencies and available dosage forms of topical corticosteroids. A good understanding of human psychology and effective communication is also needed to use these agents optimally.

  17. Do scientists trace hot topics?

    CERN Document Server

    Wei, Tian; Wu, Chensheng; Yan, XiaoYong; Fan, Ying; Di, Zengru; Wu, Jinshan

    2013-01-01

    Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of papers belonging to the field. This indicates that scientists generally do follow hot topics. However, there are qualitative differences among scientists from various countries, among research works regarding different number of authors, different number of affiliations and different number of references. These observations could be valuable for policy makers when deciding research funding and also for individual researchers when searching for scientific projects.

  18. Ethical Use of Topical Corticosteroids

    OpenAIRE

    Saraswat, Abir

    2014-01-01

    Dermatologists rely very heavily on corticosteroids for treating many common dermatoses. Concerns about their incorrect use are widely expressed both in lay public and specialist discourse. From the point of view of medical ethics, issues of autonomy, beneficence and non-maleficence are all raised frequently when we prescribe topical corticosteroids to our patients. We need to be aware of situations when conflicts between these issues arise and have a clear thought process about resolving the...

  19. Stochastic Analysis and Related Topics

    CERN Document Server

    Ustunel, Ali

    1988-01-01

    The Silvri Workshop was divided into a short summer school and a working conference, producing lectures and research papers on recent developments in stochastic analysis on Wiener space. The topics treated in the lectures relate to the Malliavin calculus, the Skorohod integral and nonlinear functionals of white noise. Most of the research papers are applications of these subjects. This volume addresses researchers and graduate students in stochastic processes and theoretical physics.

  20. Hot topics from the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Glenzinski, D.; /Fermilab

    2008-01-01

    The Tevatron Run-II began in March 2001. To date, both the CDF and D0 experiments have collected 1 fb{sup -1} of data each. The results obtained from this data set were summarized at this conference in 39 parallel session presentations covering a wide range of topics. The author summarizes the most important of those results here and comments on some of the prospects for the future.

  1. Traditional Persian topical medications for gastrointestinal diseases

    Directory of Open Access Journals (Sweden)

    Laleh Dehghani Tafti

    2017-03-01

    Full Text Available Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI ailments in Traditional Persian Medicine (TPM. TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study is to survey the topical GI remedies and plant species used as ingredients for these remedies in TPM. In addition, pharmacological activities of the mentioned plants have been discussed. For this, we searched major TPM textbooks to find plants used to cure GI problems in topical use. Additionally, scientific databases were searched to obtain pharmacological data supporting the use of TPM plants in GI diseases. Rosa × damascena, Pistacia lentiscus, Malus domestica, Olea europaea and Artemisia absinthium are among the most frequently mentioned ingredients of TPM remedies. β-asarone, amygdalin, boswellic acids, guggulsterone, crocin, crocetin, isomasticadienolic acid, and cyclotides are the most important phytochemicals present in TPM plants with GI-protective activities. Pharmacological studies demonstrated GI activities for TPM plants supporting their extensive traditional use. These plants play pivotal role in alleviating GI disorders through exhibiting numerous activities including antispasmodic, anti-ulcer, anti-secretory, anti-colitis, anti-diarrheal, antibacterial and anthelmintic properties. Several mechanisms underlie these activities including the alleviation of oxidative stress, exhibiting cytoprotective activity, down-regulation of the inflammatory cytokines, suppression of the cellular signaling pathways of inflammatory responses, improving re-epithelialization and angiogenesis, down-regulation of anti-angiogenic factors, blocking activity of acetylcholine, etc.

  2. Traditional Persian topical medications for gastrointestinal diseases

    Science.gov (United States)

    Tafti, Laleh Dehghani; Shariatpanahi, Seyyed Mahyar; Damghani, Mahmoud Mahdavi; Javadi, Behjat

    2017-01-01

    Drug delivery across the skin is used for several millennia to ease gastrointestinal (GI) ailments in Traditional Persian Medicine (TPM). TPM topical remedies are generally being applied on the stomach, lower abdomen, lower back and liver to alleviate GI illnesses such as dyspepsia, gastritis, GI ulcers, inflammatory bowel disease, intestinal worms and infections. The aim of the present study is to survey the topical GI remedies and plant species used as ingredients for these remedies in TPM. In addition, pharmacological activities of the mentioned plants have been discussed. For this, we searched major TPM textbooks to find plants used to cure GI problems in topical use. Additionally, scientific databases were searched to obtain pharmacological data supporting the use of TPM plants in GI diseases. Rosa × damascena, Pistacia lentiscus, Malus domestica, Olea europaea and Artemisia absinthium are among the most frequently mentioned ingredients of TPM remedies. β-asarone, amygdalin, boswellic acids, guggulsterone, crocin, crocetin, isomasticadienolic acid, and cyclotides are the most important phytochemicals present in TPM plants with GI-protective activities. Pharmacological studies demonstrated GI activities for TPM plants supporting their extensive traditional use. These plants play pivotal role in alleviating GI disorders through exhibiting numerous activities including antispasmodic, anti-ulcer, anti-secretory, anti-colitis, anti-diarrheal, antibacterial and anthelmintic properties. Several mechanisms underlie these activities including the alleviation of oxidative stress, exhibiting cytoprotective activity, down-regulation of the inflammatory cytokines, suppression of the cellular signaling pathways of inflammatory responses, improving re-epithelialization and angiogenesis, down-regulation of anti-angiogenic factors, blocking activity of acetylcholine, etc. PMID:28392893

  3. Tie Content in Professional Networks

    DEFF Research Database (Denmark)

    Zarzecka, Olga

    introduces the topic of this dissertation as well as the overall research question. The three next chapters are empirical studies of informal ties in professional networks of Danish senior managers, that together attempt to answer the overall research question. Chapter 2 looks into gender differences...... in resource exchanges and the effect of these differences on the number of, and extent to which, resources are provided by a network tie. Chapter 3 explores how firm underperfomance and social identity with corporate elite alter types of resources a network tie provides. Chapter 4 focuses on a tie’s internal......Professional networks of senior managers have indisputable value for them as well as for their organizations. In recent years, much attention has been given to the structure of these networks as it reflects senior managers’ opportunity to access valuable resources. Surprisingly, the actual...

  4. Professional Use of Social Media by Pharmacists: A Qualitative Study

    Science.gov (United States)

    Benetoli, Arcelio; Chen, Timothy Frank; Schaefer, Marion; Chaar, Betty B

    2016-01-01

    Background Social media is frequently used by consumers and health care professionals; however, our knowledge about its use in a professional capacity by pharmacists is limited. Objective Our aim was to investigate the professional use of social media by pharmacists. Methods In-depth semistructured interviews were conducted with practicing pharmacists (N=31) from nine countries. Interviews were recorded, transcribed verbatim, and thematically analyzed. Results Wikipedia, YouTube, and Facebook were the main social media platforms used. Professional use of social media included networking with peers, discussion of health and professional topics, accessing and sharing health and professional information, job searching, and professional promotion. Wikipedia was the participants’ first choice when seeking information about unfamiliar topics, or topics that were difficult to search for. Very few pharmacy-related contributions to Wikipedia were reported. YouTube, a video-sharing platform, was used for self-education. University lectures, “how-to” footage, and professionally made videos were commonly watched. No professional contribution was made to YouTube. Facebook, a general social networking site, was used for professional networking, promotion of achievements, and job advertisements. It also afforded engagement in professional discussions and information sharing among peers. Conclusions Participants used social media in a professional capacity, specifically for accessing and sharing health and professional information among peers. Pharmacists, as medicines experts, should take a leading role in contributing to health information dissemination in these user-friendly virtual environments, to reach not only other health care professionals but also health consumers. PMID:27663570

  5. Educating professionals

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2011-01-01

    relates to actual development work, where a social worker education program is restructured and developed, with the aim of creating optimal transfer. The social worker must 'be able to co-operate, organize, coordinate, implement, evaluate and develop social efforts’ in accordance with the curriculum. How...... does that look in practice? Based on interviews with newly-educated social workers, I have analyzed which competences the social worker (hereafter ‘he’) uses in practice, how these competences are developed, and how the student learns to apply the competences acquired in the educational program....

  6. Exploring supervised and unsupervised methods to detect topics in biomedical text

    Directory of Open Access Journals (Sweden)

    Yu Hong

    2006-03-01

    Full Text Available Abstract Background Topic detection is a task that automatically identifies topics (e.g., "biochemistry" and "protein structure" in scientific articles based on information content. Topic detection will benefit many other natural language processing tasks including information retrieval, text summarization and question answering; and is a necessary step towards the building of an information system that provides an efficient way for biologists to seek information from an ocean of literature. Results We have explored the methods of Topic Spotting, a task of text categorization that applies the supervised machine-learning technique naïve Bayes to assign automatically a document into one or more predefined topics; and Topic Clustering, which apply unsupervised hierarchical clustering algorithms to aggregate documents into clusters such that each cluster represents a topic. We have applied our methods to detect topics of more than fifteen thousand of articles that represent over sixteen thousand entries in the Online Mendelian Inheritance in Man (OMIM database. We have explored bag of words as the features. Additionally, we have explored semantic features; namely, the Medical Subject Headings (MeSH that are assigned to the MEDLINE records, and the Unified Medical Language System (UMLS semantic types that correspond to the MeSH terms, in addition to bag of words, to facilitate the tasks of topic detection. Our results indicate that incorporating the MeSH terms and the UMLS semantic types as additional features enhances the performance of topic detection and the naïve Bayes has the highest accuracy, 66.4%, for predicting the topic of an OMIM article as one of the total twenty-five topics. Conclusion Our results indicate that the supervised topic spotting methods outperformed the unsupervised topic clustering; on the other hand, the unsupervised topic clustering methods have the advantages of being robust and applicable in real world settings.

  7. Exploring supervised and unsupervised methods to detect topics in biomedical text.

    Science.gov (United States)

    Lee, Minsuk; Wang, Weiqing; Yu, Hong

    2006-03-16

    Topic detection is a task that automatically identifies topics (e.g., "biochemistry" and "protein structure") in scientific articles based on information content. Topic detection will benefit many other natural language processing tasks including information retrieval, text summarization and question answering; and is a necessary step towards the building of an information system that provides an efficient way for biologists to seek information from an ocean of literature. We have explored the methods of Topic Spotting, a task of text categorization that applies the supervised machine-learning technique naïve Bayes to assign automatically a document into one or more predefined topics; and Topic Clustering, which apply unsupervised hierarchical clustering algorithms to aggregate documents into clusters such that each cluster represents a topic. We have applied our methods to detect topics of more than fifteen thousand of articles that represent over sixteen thousand entries in the Online Mendelian Inheritance in Man (OMIM) database. We have explored bag of words as the features. Additionally, we have explored semantic features; namely, the Medical Subject Headings (MeSH) that are assigned to the MEDLINE records, and the Unified Medical Language System (UMLS) semantic types that correspond to the MeSH terms, in addition to bag of words, to facilitate the tasks of topic detection. Our results indicate that incorporating the MeSH terms and the UMLS semantic types as additional features enhances the performance of topic detection and the naïve Bayes has the highest accuracy, 66.4%, for predicting the topic of an OMIM article as one of the total twenty-five topics. Our results indicate that the supervised topic spotting methods outperformed the unsupervised topic clustering; on the other hand, the unsupervised topic clustering methods have the advantages of being robust and applicable in real world settings.

  8. Exploring supervised and unsupervised methods to detect topics in biomedical text

    Science.gov (United States)

    Lee, Minsuk; Wang, Weiqing; Yu, Hong

    2006-01-01

    Background Topic detection is a task that automatically identifies topics (e.g., "biochemistry" and "protein structure") in scientific articles based on information content. Topic detection will benefit many other natural language processing tasks including information retrieval, text summarization and question answering; and is a necessary step towards the building of an information system that provides an efficient way for biologists to seek information from an ocean of literature. Results We have explored the methods of Topic Spotting, a task of text categorization that applies the supervised machine-learning technique naïve Bayes to assign automatically a document into one or more predefined topics; and Topic Clustering, which apply unsupervised hierarchical clustering algorithms to aggregate documents into clusters such that each cluster represents a topic. We have applied our methods to detect topics of more than fifteen thousand of articles that represent over sixteen thousand entries in the Online Mendelian Inheritance in Man (OMIM) database. We have explored bag of words as the features. Additionally, we have explored semantic features; namely, the Medical Subject Headings (MeSH) that are assigned to the MEDLINE records, and the Unified Medical Language System (UMLS) semantic types that correspond to the MeSH terms, in addition to bag of words, to facilitate the tasks of topic detection. Our results indicate that incorporating the MeSH terms and the UMLS semantic types as additional features enhances the performance of topic detection and the naïve Bayes has the highest accuracy, 66.4%, for predicting the topic of an OMIM article as one of the total twenty-five topics. Conclusion Our results indicate that the supervised topic spotting methods outperformed the unsupervised topic clustering; on the other hand, the unsupervised topic clustering methods have the advantages of being robust and applicable in real world settings. PMID:16539745

  9. Psychology and Nuclear Weapon Issues: Topics, Concepts, and Bibliography.

    Science.gov (United States)

    Nelson, Linden, Comp.

    The document outlines 15 topics, each with concepts and selected references, to illustrate the relevance of psychology for understanding and coping with the threat of nuclear war. Awareness of the literature is intended to encourage psychologists to become more active in applying psychological concepts to nuclear weapons issues. The articles and…

  10. Topics in Finance: Part VIII--Mergers & Acquisitions

    Science.gov (United States)

    Laux, Judy

    2012-01-01

    In this series, three key axioms--stockholder wealth maximization, the risk-return tradeoff, and agency conflicts--are applied to the major topics in financial management. The current article looks at mergers and acquisitions, reviewing the presumed motivations, the ethical challenges, and the literature dedicated to this financial activity.

  11. Current topics in summability theory and applications

    CERN Document Server

    Rhoades, Billy

    2016-01-01

    This book discusses recent developments in and contemporary research on summability theory, including general summability methods, direct theorems on summability, absolute and strong summability, special methods of summability, functional analytic methods in summability, and related topics and applications. All contributing authors are eminent scientists, researchers and scholars in their respective fields, and hail from around the world. The book can be used as a textbook for graduate and senior undergraduate students, and as a valuable reference guide for researchers and practitioners in the fields of summability theory and functional analysis. Summability theory is generally used in analysis and applied mathematics. It plays an important part in the engineering sciences, and various aspects of the theory have long since been studied by researchers all over the world. .

  12. Affective topic model for social emotion detection.

    Science.gov (United States)

    Rao, Yanghui; Li, Qing; Wenyin, Liu; Wu, Qingyuan; Quan, Xiaojun

    2014-10-01

    The rapid development of social media services has been a great boon for the communication of emotions through blogs, microblogs/tweets, instant-messaging tools, news portals, and so forth. This paper is concerned with the detection of emotions evoked in a reader by social media. Compared to classical sentiment analysis conducted from the writer's perspective, analysis from the reader's perspective can be more meaningful when applied to social media. We propose an affective topic model with the intention to bridge the gap between social media materials and a reader's emotions by introducing an intermediate layer. The proposed model can be used to classify the social emotions of unlabeled documents and to generate a social emotion lexicon. Extensive evaluations using real-world data validate the effectiveness of the proposed model for both these applications. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Topics on Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Directorate (NVE). To prevent cross-subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. Chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently coordinate the

  14. Topics in Electricity Transmission Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Bjoerndal, Mette

    2000-02-01

    Directorate (NVE). To prevent cross-subsidization, the largest state-owned firm was split to form Statkraft SF, Norway's largest generation company, and Statnett SF, the major transmission company. Statnett is also the system operator of the entire Norwegian power system. Many distribution companies, usually publicly owned, are still part of vertically integrated companies, but there is strict separation of the financial accounts for transmission/distribution and generation/marketing. Trading is accomplished through several channels. The largest organized market is the common Norwegian-Swedish pool, NordPool. NordPool ASA is owned by Statnett Marked (which is a subsidiary of Statnett) and the Swedish grid-company, Svenska Kraftnaet. NordPool also supports the Finnish and Danish markets, thus through cooperation with the grid-companies of Denmark (Eltra) and Finland (Fingrid), locational markets are provided in these countries as well. Unlike England and Wales, only part of actual production is traded on this market. In addition, independent brokers offer various energy-contracts and facilitate bilateral contracts. In 1998 22% of the energy was traded on the hourly day-ahead (spot) market of NordPool. NordPool also organizes a forward and futures market and settles contracts from the regulation market organized by Statnett. The regulation market is a realtime market used to settle imbalances in real time. In total, close to 30% of the energy traded is organized through NordPool, and this share is increasing year by year. The efficiency of the market is heavily affected by the operation and pricing of the transmission system, and the topic of this thesis concerns the interaction of the transmission network and the energy markets. Throughout, the findings are illustrated by means of simple examples. This is to enhance readability and intuition. To start with, chapter 2 is devoted to power flow models, whereas chapter 3 provides an overview of models developed to efficiently

  15. Topic extraction from adverbial clauses

    Directory of Open Access Journals (Sweden)

    Carlos Rubio Alcalá

    2016-06-01

    Full Text Available This paper offers new data to support findings about Topic extraction from adverbial clauses. Since such clauses are strong islands, they should not allow extraction of any kind, but we show here that if the appropriate conditions are met, Topics of the CLLD kind in Romance can move out of them. We propose that two conditions must be met for such movement to be possible: the first is that the adverbial clause must have undergone topicalisation in the first place; the second is that the adverbial clause is inherently topical from a semantic viewpoint. Contrast with other language families (Germanic, Quechua and Japanese is provided and the semantic implications of the proposal are briefly discussed. Keywords: topicalisation; Clitic Left Dislocation; syntactic islands; adverbial clauses Este artículo ofrece nuevos datos sobre la extracción de Tópicos desde oraciones subordinadas adverbiales. Dado que dichas oraciones son islas fuertes, no deberían permitir extracción de ningún tipo, pero mostramos que si se dan las condiciones apropiadas, los Tópicos del tipo CLLD en lenguas románicas pueden desplazarse fuera de ellas. Proponemos que se deben cumplir dos condiciones para que ese movimiento sea posible: la primera es que la propia subordinada adverbial se haya topicalizado en primer lugar; la segunda es que la subordinada adverbial sea inherentemente un Tópico desde el punto de vista semántico. Proporcionamos también algunos contrastes con otras familias lingüísticas (germánica, quechua y japonés y se discuten brevemente las implicaciones semánticas de la propuesta. Palabras clave: topicalización; dislocación a la izquierda con clítico; islas sintácticas; oraciones adverbiales

  16. New patents on topical anesthetics.

    Science.gov (United States)

    Cantisani, Carmen; Macaluso, Laura; Frascani, Federica; Paolino, Giovanni; D'Andrea, Vito; Richetta, Antonio G; Calvieri, Stefano

    2014-01-01

    Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected. General anesthesia is a reversible state of unconsciousness produced by anesthetic agents, characterized by amnesia, muscle relaxation and loss of sensitivity to pain of the whole body. General anesthetic drugs can be classified into two main groups according to their predominant molecular pharmacological effects: volatile and intravenous agents. Local anesthesia produce a reversible loss of sensation in a portion of the body and it reversibly block impulse conduction along nerve axons and other excitable membrane. All local anesthetics (LA) are membrane stabilizing drugs; they reversibly decrease the rate of depolarization and repolarization of excitable membranes. They act mainly by inhibiting sodium influx through sodium-specific ion channels in the neuronal cell membrane, in particular the voltage-gated sodium channels. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is inhibited. The main local anesthetic (LA) agents for skin anesthesia are benzocaine (aminoester), prilocaine and lidocaine (aminoamides) which are commercially available as gels, ointments and creams (benzocaine and eutectic mixture of lidocaine and prilocaine) or as a bioadhesive (lidocaine) with different compositions (vehicles and excipients) for adults or pediatric use. Topical anesthetics decrease anxiety, pain and discomfort during cutaneous procedures and provide effective analgesia with rapid onset, prolonged duration and minimal side effects. This article outlines the different classes of topical anesthetics available and gives an overview of the mechanism of action, metabolism of each different class, of the possible complications that can occur because of their use and their possible treatment options and new patents.

  17. Modern topics in electron scattering

    CERN Document Server

    Frois, Bernard

    1991-01-01

    This book summarizes the considerable progress recently achieved in the understanding of nucleon and nuclear structure by using high energy electrons as a probe. A collection of papers discusses in detail the new frontiers of this field. Experimental and theoretical articles cover topics such as the structure of the nucleon, nucleon distributions, many-body correlations, non-nucleonic degrees of freedom and few-body systems. This book is an up-to-date introduction to the research planned with continuous beam electron accelerators.

  18. Potential theory—selected topics

    CERN Document Server

    Aikawwa, Hiroaki

    1996-01-01

    The first part of these lecture notes is an introduction to potential theory to prepare the reader for later parts, which can be used as the basis for a series of advanced lectures/seminars on potential theory/harmonic analysis. Topics covered in the book include minimal thinness, quasiadditivity of capacity, applications of singular integrals to potential theory, L(p)-capacity theory, fine limits of the Nagel-Stein boundary limit theorem and integrability of superharmonic functions. The notes are written for an audience familiar with the theory of integration, distributions and basic functional analysis.

  19. Topics in atomic collision theory

    CERN Document Server

    Geltman, Sydney; Brueckner, Keith A

    1969-01-01

    Topics in Atomic Collision Theory originated in a course of graduate lectures given at the University of Colorado and at University College in London. It is recommended for students in physics and related fields who are interested in the application of quantum scattering theory to low-energy atomic collision phenomena. No attention is given to the electromagnetic, nuclear, or elementary particle domains. The book is organized into three parts: static field scattering, electron-atom collisions, and atom-atom collisions. These are in the order of increasing physical complexity and hence necessar

  20. Topics in computational linear optimization

    DEFF Research Database (Denmark)

    Hultberg, Tim Helge

    2000-01-01

    of high quality solvers and the use of algebraic modelling systems to handle the communication between the modeller and the solver. This dissertation features four topics in computational linear optimization: A) automatic reformulation of mixed 0/1 linear programs, B) direct solution of sparse unsymmetric...... of an augmented system is computed. This involves the solution of a sparse triangular system with 's' right-hand sides. Solution sparsity is exploited in the sparse triangular solves of the block LU factorization. 3) a factorization of the Schur complement matrix, of order 's', is computed. The idea...

  1. Students' Independent Professional Activity in Pedagogical Practice

    National Research Council Canada - National Science Library

    Strode, Aina

    2010-01-01

    ... and an opportunity for new specialists to align with the labour market. The empirical study of students' understanding of their professional activity and of the conditions for its formation is conducted by applying structured interviews...

  2. Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis

    Directory of Open Access Journals (Sweden)

    Salih Levent Cinar

    2017-01-01

    Full Text Available Background: The skin is one of the most affected organs in tuberous sclerosis complex and angiofibromas are seen in almost 80% of such patients. These benign tumors impose a great psycho-social burden on patients. Objective: The aim of the study was to evaluate the effectiveness and tolerability of topical sirolimus for facial angiofibromas in patients with tuberous sclerosis complex. Methods: This was a prospective, single-blinded, cross-over study which involved twelve patients. We investigated the effect and safety of topical 0.1% sirolimus, which was obtained by crushing sirolimus tablets and mixing it with petrolatum. The patients were asked to apply the cream to one side of their face, and vaseline to the other side. The effect of topical sirolimus was evaluated using the “facial angiofibroma severity index.” Results: There was a significant improvement in the redness and extension of the tumors on the sides to which the active ingredient was applied. Some side effects such as itching and irritation occurred in three patients, which were treated with topical hydrocortisone cream. Conclusion: Topical sirolimus appears to be a promising, fairly well tolerated treatment for facial angiofibromas in patients with tuberous sclerosis complex. Although its efficacy diminishes with time, repetitive usage is effective.

  3. Online professionalism: A synthetic review.

    Science.gov (United States)

    Chretien, Katherine C; Tuck, Matthew G

    2015-04-01

    The rise of social media has increased connectivity and blurred personal and professional boundaries, bringing new challenges for medical professionalism. Whether traditional professionalism principles apply to the online social media space remains unknown. The purpose of this synthetic literature review was to characterize the original peer-reviewed research studies published between 1 January 2000-1 November 2014 on online professionalism, to assess methodologies and approaches used, and to provide insights to guide future studies in this area. The investigators searched three databases and performed manual searches of bibliographies to identify the 32 studies included. Most studies originated in the USA. Cross-sectional surveys and analyses of publicly available online content were the most common methodologies employed. Studies covered the general areas of use and privacy, assessment of unprofessional online behaviours, consensus-gathering of what constitutes unprofessional or inappropriate online behaviours, and education and policies. Studies were of variable quality; only around half of survey studies had response rates of 50% or greater. Medical trainees were the most common population studied. Future directions for research include public perspectives of online professionalism, impact on patient trust, and how to use social media productively as medical professionals.

  4. Topicality and impact in social media: diverse messages, focused messengers.

    Directory of Open Access Journals (Sweden)

    Lilian Weng

    Full Text Available We have a limited understanding of the factors that make people influential and topics popular in social media. Are users who comment on a variety of matters more likely to achieve high influence than those who stay focused? Do general subjects tend to be more popular than specific ones? Questions like these demand a way to detect the topics hidden behind messages associated with an individual or a keyword, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags in Twitter by detecting communities in the hashtag co-occurrence network. Then the topical diversity of a user's interests is quantified by the entropy of her hashtags across different topic clusters. A similar measure is applied to hashtags, based on co-occurring tags. We find that high topical diversity of early adopters or co-occurring tags implies high future popularity of hashtags. In contrast, low diversity helps an individual accumulate social influence. In short, diverse messages and focused messengers are more likely to gain impact.

  5. Topicality and impact in social media: diverse messages, focused messengers.

    Science.gov (United States)

    Weng, Lilian; Menczer, Filippo

    2015-01-01

    We have a limited understanding of the factors that make people influential and topics popular in social media. Are users who comment on a variety of matters more likely to achieve high influence than those who stay focused? Do general subjects tend to be more popular than specific ones? Questions like these demand a way to detect the topics hidden behind messages associated with an individual or a keyword, and a gauge of similarity among these topics. Here we develop such an approach to identify clusters of similar hashtags in Twitter by detecting communities in the hashtag co-occurrence network. Then the topical diversity of a user's interests is quantified by the entropy of her hashtags across different topic clusters. A similar measure is applied to hashtags, based on co-occurring tags. We find that high topical diversity of early adopters or co-occurring tags implies high future popularity of hashtags. In contrast, low diversity helps an individual accumulate social influence. In short, diverse messages and focused messengers are more likely to gain impact.

  6. Professionalism: a framework to guide medical education.

    Science.gov (United States)

    Brody, Howard; Doukas, David

    2014-10-01

    Despite considerable advances in the incorporation of professionalism into the formal curriculum, medical students and residents are too often presented with a mechanical, unreflective version of the topic that fails to convey deeper ethical and humanistic aspirations. Some misunderstandings of professionalism are exacerbated by commonly used assessment tools that focus only on superficially observable behaviour and not on moral values and attitudes. Following a selective literature review, we engaged in philosophical ethical analysis to identify the key precepts associated with professionalism that could best guide the development of an appropriately reflective curriculum. The key precepts needed for a robust presentation of professionalism can be grouped under two headings: 'Professionalism as a trust-generating promise' (representing commitment to patients' interests, more than a mere business, a social contract, a public and collective promise, and hard work), and 'Professionalism as application of virtue to practice' (based on virtue, deeper attitudes rather than mere behaviour, and requiring of practical wisdom). These key precepts help students to avoid many common, unreflective misunderstandings of professionalism, and guide faculty staff and students jointly to address the deeper issues required for successful professional identity formation. © 2014 John Wiley & Sons Ltd.

  7. TOPIC: CLINICAL NURSING RESEARCH: A TOOL FOR ...

    African Journals Online (AJOL)

    DR. MRS. AKPABIO

    other professional staff in the health arena for the purpose of improving patient care and health outcomes. There could therefore, not exist any professional development in Nursing without clinical nursing research. Professional development involves professional standards, increased accountabilities, effective and efficient ...

  8. Satellite DNA: An Evolving Topic

    Directory of Open Access Journals (Sweden)

    Manuel A. Garrido-Ramos

    2017-09-01

    Full Text Available Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS, together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes. The whole of the historical and current approaches to the topic gives us a broad view of the function and evolution of satellite DNA and its role in chromosomal evolution. Currently, we have extensive information on the molecular, chromosomal, biological, and population factors that affect the evolutionary fate of satellite DNA, knowledge that gives rise to a series of hypotheses that get on well with each other about the origin, spreading, and evolution of satellite DNA. In this paper, I review these hypotheses from a methodological, conceptual, and historical perspective and frame them in the context of chromosomal organization and evolution.

  9. Satellite DNA: An Evolving Topic.

    Science.gov (United States)

    Garrido-Ramos, Manuel A

    2017-09-18

    Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot of literature has extensively covered various topics related to the structure, organization, function, and evolution of such sequences. Today, with the advent of genomic tools, the study of satellite DNA has regained a great interest. Thus, Next-Generation Sequencing (NGS), together with high-throughput in silico analysis of the information contained in NGS reads, has revolutionized the analysis of the repetitive fraction of the eukaryotic genomes. The whole of the historical and current approaches to the topic gives us a broad view of the function and evolution of satellite DNA and its role in chromosomal evolution. Currently, we have extensive information on the molecular, chromosomal, biological, and population factors that affect the evolutionary fate of satellite DNA, knowledge that gives rise to a series of hypotheses that get on well with each other about the origin, spreading, and evolution of satellite DNA. In this paper, I review these hypotheses from a methodological, conceptual, and historical perspective and frame them in the context of chromosomal organization and evolution.

  10. Conference report: hot topics in antibody-drug conjugate development.

    Science.gov (United States)

    Thudium, Karen; Bilic, Sanela

    2013-12-01

    American Association of Pharmaceutical Scientists National Biotechnology Conference Sheraton San Diego Hotel and Marina, San Diego, CA, USA, 19-23 May 2013 The National Biotechnology Conference, is a premier meeting for biotechnology professionals covering a broad range of hot topics in the biotechnology industry. Attracting participants from academia, industry and regulatory, this meeting features sessions that aim to address emerging subjects of interest and allows for open exchange between scientists. The 2013 conference featured leading researchers in the fields of antibody-drug conjugates (ADCs) and immunogenicity. Herein, we present a summary of the ADC hot topics, including bioanalytical and PK considerations, quantitative evaluation of the impact of immunogenicity and ADME to understand ADC drug-drug interactions, and clinical considerations for ADC development. This article aims to summarize the recommendations that were made by the speakers during various sessions throughout the conference.

  11. US Support Program Topical Meetings 1999 to 2008

    Energy Technology Data Exchange (ETDEWEB)

    Pepper,S.

    2008-06-10

    In 1999, the International Safeguards Project Office began organizing topical workshops to explore technical issues facing the International Atomic Energy Agency's Department of Safeguards. Representatives from IAEA member states including the United States, national laboratories and companies were invited to the workshops to discuss the technical issues. In some cases professional facilitators were hired to lead the discussions and in some cases business gaming techniques were employed. Since 1999, the following topics have been addressed Data Communication Technologies (1999), Information Security (2000), Design and Testing for High Reliability (2001), Standardization and Integration of Unattended and Remote Monitoring Systems (2002), Roadmapping: Surveillance (2003), IAEA Seals Technology Roadmapping Workshop (2004), Turning Information Into Knowledge (2004), Safeguards Tools of the Future (2005), and Advanced Sensors for Safeguards (2007). This paper will review the scope of the workshops and summarize their results.

  12. Challenges in the professional care encounters

    DEFF Research Database (Denmark)

    Kaldal, Maiken Holm; Kristiansen, Jette; Uhrenfeldt, Lisbeth

    2017-01-01

    reactions. It is essential that the faculties prepare and guide the students before, during and after the professional care encounter to assist the development of educational strategies to prevent attrition and to the topic “The Established Relationship between the Nurse and Patient” curricula...... are challenged by their personal boundaries in the professional care encounter and they experience a great psychological impact Patient contact is an unavoidable and complex component in the nursing education. The students have not yet built up a professional filter and are exposed to a wealth of emotional......To prepare and guide the nursing students through their clinical periods, evidence on the students’ experiences of professional care encounters in a hospital unit, is required. A systematic review following The Joanna Briggs Institute guidelines. Five qualitative research articles were included...

  13. An identification and critical analysis of barriers to raising the topic of weight in general practice

    OpenAIRE

    Blackburn, Maxine

    2015-01-01

    In light of the increasing prevalence of obesity in the UK, health professionals working within general practice are urged to initiate discussion about weight with overweight and obese patients. Despite such appeals, evidence suggests that only a minority of health professionals routinely talk to patients about weight loss. To understand more about the barriers to raising the topic of weight in general practice, three empirical studies guided by qualitative research design were carried out. T...

  14. Topical fentanyl stimulates healing of ischemic wounds in diabetic rats

    Science.gov (United States)

    FAROOQUI, Mariya; ERICSON, Marna E; GUPTA, Kalpna

    2016-01-01

    Background Topically applied opioids promote angiogenesis and healing of ischemic wounds in rats. We examined if topical fentanyl stimulates wound healing in diabetic rats by stimulating growth-promoting signaling, angiogenesis, lymphangiogenesis and nerve regeneration. Methods We used Zucker diabetic fatty rats that develop obesity and diabetes on a high fat diet due to a mutation in the Leptin receptor. Fentanyl blended with hydrocream was applied topically on ischemic wounds twice daily, and wound closure was analyzed regularly. Wound histology was analyzed by hematoxylin and eosin staining. Angiogenesis, lymphangiogenesis, nerve fibers and phospho-PDGFR-β were visualized by CD31-, lymphatic vessel endothelium-1, protein gene product 9.5- and anti-phospho PDGFR-β-immunoreactivity, respectively. Nitric oxide synthase (NOS) and PDGFR-β signaling were analyzed using Western immunoblotting. Results Fentanyl significantly promoted wound closure as compared to PBS. Histology scores were significantly higher in fentanyl-treated wounds, indicative of increased granulation tissue formation, reduced edema and inflammation, and increased matrix deposition. Fentanyl treatment resulted in increased wound angiogenesis, lymphatic vasculature, nerve fibers, nitric oxide, NOS and PDGFR-β signaling as compared to PBS. Phospho PDGFR-β co-localized with CD31 co-staining for vasculature. Conclusions Topically applied fentanyl promotes closure of ischemic wounds in diabetic rats. Increased angiogenesis, lymphangiogenesis, peripheral nerve regeneration, NO and PDGFR-β signaling are associated with fentanyl-induced tissue remodeling and wound healing. PMID:25266258

  15. Topical Conference on Oportunities in Biology for Physicists II

    Energy Technology Data Exchange (ETDEWEB)

    Franz, Judy R.

    2004-02-01

    In 2002, the American Physical Society (APS) organized and held the first topical conference in Boston, MA, as a way of informing physicists, particularly those just entering the field, of opportunities emerging at the interface of physics and biology. Because of the tremendous success of the first conference, it was decided to organize a second conference, similar in nature and focus, but with different presentation topic areas. Again the intended audience would be graduate students and postdocs considering applying methods of physics to biological research, and those who advise others on such opportunities.

  16. Neomycin, Polymyxin, and Bacitracin Topical

    Science.gov (United States)

    ... not use this medication to treat deep cuts, puncture wounds, animal bites, serious burns, or any injuries ... injured area with soap and water and pat dry thoroughly with a clean towel. Apply a small ...

  17. Topics and Research Directions for Symmetric Cryptography

    OpenAIRE

    Biryukov, Alex; Daemen, Joan; Lucks, Stefan; Vaudenay, Serge

    2017-01-01

    This is a summary of the open discussion on future research topics for symmetric cryptography chaired by Stefan Lucks. During this session participants were suggesting topics of potential future interest.

  18. Mammography: MedlinePlus Health Topic

    Science.gov (United States)

    ... Administration) - PDF Mammography (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Mammography updates by ... Breast cancer screenings Mammogram - calcifications Mammography Related Health Topics Breast Cancer Breast Diseases National Institutes of Health ...

  19. Prediabetes:MedlinePlus Health Topic

    Science.gov (United States)

    ... in Spanish Prediabetes (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Prediabetes updates by ... Glucose tolerance test - non-pregnant Prediabetes Related Health Topics A1C Diabetes Diabetes in Children and Teens Diabetes ...

  20. Dialysis: MedlinePlus Health Topic

    Science.gov (United States)

    ... access for hemodialysis (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Dialysis updates by ... for hemodialysis Show More Show Less Related Health Topics Creatinine Kidney Cysts Kidney Failure Peritoneal Disorders National ...

  1. Pulmonary Rehabilitation: MedlinePlus Health Topic

    Science.gov (United States)

    ... Handouts Postural drainage (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pulmonary Rehabilitation updates ... this? GO MEDICAL ENCYCLOPEDIA Postural drainage Related Health Topics Lung Diseases National Institutes of Health The primary ...

  2. Vaginal Bleeding: MedlinePlus Health Topic

    Science.gov (United States)

    ... bleeding in pregnancy (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Vaginal Bleeding updates ... late pregnancy Vaginal bleeding in pregnancy Related Health Topics Menstruation Disclaimers MedlinePlus links to health information from ...

  3. Pain Relievers: MedlinePlus Health Topic

    Science.gov (United States)

    ... for back pain (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Pain Relievers updates ... Tolmetin overdose Show More Show Less Related Health Topics Chronic Pain Medicines Opioid Abuse and Addiction Over- ...

  4. Collapsed Lung: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Pneumothorax - infants (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Collapsed Lung updates ... Lung surgery Pneumothorax - slideshow Pneumothorax - infants Related Health Topics Chest Injuries and Disorders Lung Diseases Pleural Disorders ...

  5. Gastrointestinal Bleeding: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Vomiting blood (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Gastrointestinal Bleeding updates ... Vomiting blood Show More Show Less Related Health Topics Hemorrhoids Peptic Ulcer National Institutes of Health The ...

  6. Vaginitis: MedlinePlus Health Topic

    Science.gov (United States)

    ... Spanish Vulvovaginitis - overview (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Vaginitis updates by ... Vaginitis test - wet mount Vulvovaginitis - overview Related Health Topics Trichomoniasis Vaginal Diseases Yeast Infections Other Languages Find ...

  7. Pneumococcal Infections: MedlinePlus Health Topic

    Science.gov (United States)

    ... Prevention, Immunization Action Coalition) - PDF Also in Spanish Topic Image MedlinePlus Email Updates Get Pneumococcal Infections updates ... ray Meningitis - pneumococcal Sputum gram stain Related Health Topics Meningitis Pneumonia Sepsis Sinusitis Streptococcal Infections National Institutes ...

  8. Eye Care: MedlinePlus Health Topic

    Science.gov (United States)

    ... Institute) Sports and Your Eyes (National Eye Institute) Topic Image MedlinePlus Email Updates Get Eye Care updates by email What's this? GO Related Health Topics Eye Diseases Eye Infections Eye Injuries Eye Wear ...

  9. Yeast Infections: MedlinePlus Health Topic

    Science.gov (United States)

    ... Vaginal yeast infection (Medical Encyclopedia) Also in Spanish Topic Image MedlinePlus Email Updates Get Yeast Infections updates ... gram stain Thrush Vaginal yeast infection Related Health Topics Fungal Infections Vaginitis National Institutes of Health The ...

  10. Healthy Aging: MedlinePlus Health Topic

    Science.gov (United States)

    ... Older Adults) (Centers for Disease Control and Prevention) Nutrition for Seniors: MedlinePlus Health Topic (National Library of Medicine) Also ... over 65 Related Health Topics Exercise for Seniors Nutrition for Seniors Seniors' Health National Institutes of Health The primary ...

  11. Infection Control: MedlinePlus Health Topic

    Science.gov (United States)

    ... infections when visiting (Medical Encyclopedia) Also in Spanish Staph infections - hospital (Medical Encyclopedia) Also in Spanish Topic ... precautions Personal protective equipment Preventing infections when visiting Staph infections - hospital Related Health Topics Hepatitis HIV/AIDS ...

  12. The Topical Counterplan: A Competitive Policy Alternative.

    Science.gov (United States)

    Panetta, Edward M.; Dolley, Steven

    1989-01-01

    Argues that traditional requirements that a counterplan cannot be topical should be reconsidered by the policy debate community. Contends that the acceptance of the topical counterplan reduces the schism between theory and practice in debate. (MS)

  13. Human-competitive automatic topic indexing

    CERN Document Server

    Medelyan, Olena

    2009-01-01

    Topic indexing is the task of identifying the main topics covered by a document. These are useful for many purposes: as subject headings in libraries, as keywords in academic publications and as tags on the web. Knowing a document’s topics helps people judge its relevance quickly. However, assigning topics manually is labor intensive. This thesis shows how to generate them automatically in a way that competes with human performance. Three kinds of indexing are investigated: term assignment, a task commonly performed by librarians, who select topics from a controlled vocabulary; tagging, a popular activity of web users, who choose topics freely; and a new method of keyphrase extraction, where topics are equated to Wikipedia article names. A general two-stage algorithm is introduced that first selects candidate topics and then ranks them by significance based on their properties. These properties draw on statistical, semantic, domain-specific and encyclopedic knowledge. They are combined using a machine learn...

  14. KEY TOPICS IN SPORTS MEDICINE

    Directory of Open Access Journals (Sweden)

    Amir Ali Narvani

    2006-12-01

    Full Text Available Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1 Sports injuries, rehabilitation and injury prevention, 2 Exercise physiology, fitness testing and training, 3 Drugs in sport, 4 Exercise and health promotion, 5 Sport and exercise for special and clinical populations, 6 The psychology of performance and injury. PURPOSE The Key Topics format provides extensive, concise information in an accessible, easy-to-follow manner. AUDIENCE The book is targeted the students and specialists in sports medicine and rehabilitation, athletic training, physiotherapy and orthopaedic surgery. The editors are authorities in their respective fields and this handbook depends on their extensive experience and knowledge accumulated over the years. FEATURES The book contains the information for clinical guidance, rapid access to concise details and facts. It is composed of 99 topics which present the information in an order that is considered logical and progressive as in most texts. Chapter headings are: 1. Functional Anatomy, 2. Training Principles / Development of Strength and Power, 3. Biomechanical Principles, 4. Biomechanical Analysis, 5. Physiology of Training, 6. Monitoring of Training Progress, 7. Nutrition, 8. Hot and Cold Climates, 9. Altitude, 10. Sport and Travelling, 11. Principles of Sport Injury Diagnosis, 12. Principles of Sport and Soft Tissue Management, 13. Principles of Physical Therapy and Rehabilitation, 14. Principles of Sport Injury Prevention, 15. Sports Psychology, 16. Team Sports, 17. Psychological Aspects of Injury in Sport, 18. Injury Repair Process, 19. Basic Biomechanics of Tissue Injury, 20. Plain Film Radiography in Sport, 21. Nuclear Medicine, 22. Diagnostic Ultrasound, 23. MRI Scan, 24. Other Imaging, 5. Head Injury, 26. Eye

  15. Synergetics introduction and advanced topics

    CERN Document Server

    Haken, Hermann

    2004-01-01

    This book is an often-requested reprint of two classic texts by H. Haken: "Synergetics. An Introduction" and "Advanced Synergetics". Synergetics, an interdisciplinary research program initiated by H. Haken in 1969, deals with the systematic and methodological approach to the rapidly growing field of complexity. Going well beyond qualitative analogies between complex systems in fields as diverse as physics, chemistry, biology, sociology and economics, Synergetics uses tools from theoretical physics and mathematics to construct an unifying framework within which quantitative descriptions of complex, self-organizing systems can be made. This may well explain the timelessness of H. Haken's original texts on this topic, which are now recognized as landmarks in the field of complex systems. They provide both the beginning graduate student and the seasoned researcher with solid knowledge of the basic concepts and mathematical tools. Moreover, they admirably convey the spirit of the pioneering work by the founder of ...

  16. Topics in Banach space theory

    CERN Document Server

    Albiac, Fernando

    2016-01-01

    This text provides the reader with the necessary technical tools and background to reach the frontiers of research without the introduction of too many extraneous concepts. Detailed and accessible proofs are included, as are a variety of exercises and problems. The two new chapters in this second edition are devoted to two topics of much current interest amongst functional analysts: Greedy approximation with respect to bases in Banach spaces and nonlinear geometry of Banach spaces. This new material is intended to present these two directions of research for their intrinsic importance within Banach space theory, and to motivate graduate students interested in learning more about them. This textbook assumes only a basic knowledge of functional analysis, giving the reader a self-contained overview of the ideas and techniques in the development of modern Banach space theory. Special emphasis is placed on the study of the classical Lebesgue spaces Lp (and their sequence space analogues) and spaces of continuous f...

  17. Applied computational physics

    CERN Document Server

    Boudreau, Joseph F; Bianchi, Riccardo Maria

    2018-01-01

    Applied Computational Physics is a graduate-level text stressing three essential elements: advanced programming techniques, numerical analysis, and physics. The goal of the text is to provide students with essential computational skills that they will need in their careers, and to increase the confidence with which they write computer programs designed for their problem domain. The physics problems give them an opportunity to reinforce their programming skills, while the acquired programming skills augment their ability to solve physics problems. The C++ language is used throughout the text. Physics problems include Hamiltonian systems, chaotic systems, percolation, critical phenomena, few-body and multi-body quantum systems, quantum field theory, simulation of radiation transport, and data modeling. The book, the fruit of a collaboration between a theoretical physicist and an experimental physicist, covers a broad range of topics from both viewpoints. Examples, program libraries, and additional documentatio...

  18. Beginning Python from novice to professional

    CERN Document Server

    Hetland, Magnus Lie

    2005-01-01

    ""Beginning Python: From Novice to Professional"" is the most comprehensive book on the Python ever written. Based on ""Practical Python,"" this newly revised book is both an introduction and practical reference for a swath of Python-related programming topics, including addressing language internals, database integration, network programming, and web services. Advanced topics, such as extending Python and packaging/distributing Python applications, are also covered. Ten different projects illustrate the concepts introduced in the book. You will learn how to create a P2P file-sharing applicati

  19. Evaluating your professionalism.

    Science.gov (United States)

    Burr, Steven; Neve, Hilary; Leung, Yee

    2016-11-02

    What does being professional look like? Does it mean that you do the 'right' thing, even when no-one is looking? How do you evaluate your professionalism knowledge, values and behaviour? How do you identify and address underperformance in professionalism? How can you transfer your professionalism to different circumstances?

  20. Applied probability and stochastic processes

    CERN Document Server

    Sumita, Ushio

    1999-01-01

    Applied Probability and Stochastic Processes is an edited work written in honor of Julien Keilson. This volume has attracted a host of scholars in applied probability, who have made major contributions to the field, and have written survey and state-of-the-art papers on a variety of applied probability topics, including, but not limited to: perturbation method, time reversible Markov chains, Poisson processes, Brownian techniques, Bayesian probability, optimal quality control, Markov decision processes, random matrices, queueing theory and a variety of applications of stochastic processes. The book has a mixture of theoretical, algorithmic, and application chapters providing examples of the cutting-edge work that Professor Keilson has done or influenced over the course of his highly-productive and energetic career in applied probability and stochastic processes. The book will be of interest to academic researchers, students, and industrial practitioners who seek to use the mathematics of applied probability i...

  1. Credibility improves topical blog post retrieval

    NARCIS (Netherlands)

    Weerkamp, W.; de Rijke, M.

    2008-01-01

    Topical blog post retrieval is the task of ranking blog posts with respect to their relevance for a given topic. To improve topical blog post retrieval we incorporate textual credibility indicators in the retrieval process. We consider two groups of indicators: post level (determined using

  2. Successful design and delivery of a professional poster.

    Science.gov (United States)

    Berg, Judith; Hicks, Rod

    2017-08-01

    Poster presentations are increasingly popular for dissemination of scientific and clinical knowledge at professional meetings; however, this professional skill is generally absent from advanced practice registered nurse (APRN) curricula and acquisition of the skill must occur in other arenas. The purpose of this article is to promote professional development by educating APRNs, students, and faculty on the essentials of poster development and presentation. To aid in poster presentation skill development, types of posters, advantages and disadvantages, content and design, and tips to enhance these presentations are discussed. What is known on these topics is summarized and emphasis on professional appearance and conduct is highlighted. Content and layout, use of color, imagery, and positive and negative space are crucial design elements. Poster presentation essentials include being prepared, professional appearance, and professional behavior. Designing and presenting a professional poster is an essential skill for all APRNs as the ability to communicate knowledge is central to the role. ©2017 American Association of Nurse Practitioners.

  3. Applied survival analysis using R

    CERN Document Server

    Moore, Dirk F

    2016-01-01

    Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Many survival methods are extensions of techniques used in linear regression and categorical data, while other aspects of this field are unique to survival data. This text employs numerous actual examples to illustrate survival curve estimation, comparison of survivals of different groups, proper accounting for censoring and truncation, model variable selection, and residual analysis. Because explaining survival analysis requires more advanced mathematics than many other statistical topics, this book is organized with basic concepts and most frequently used procedures covered in earlier chapters, with more advanced topics...

  4. Enhanced uptake and photoactivation of topical methyl aminolevulinate after fractional CO2 laser pretreatment

    DEFF Research Database (Denmark)

    Haedersdal, M; Katsnelson, J; Sakamoto, F H

    2011-01-01

    Photodynamic therapy (PDT) of thick skin lesions is limited by topical drug uptake. Ablative fractional resurfacing (AFR) creates vertical channels that may facilitate topical PDT drug penetration and improve PDT-response in deep skin layers. The purpose of this study was to evaluate whether pre......-treating the skin with AFR before topically applied methyl aminolevulinate (MAL) could enable a deep PDT-response....

  5. Understanding topics and sentiment in an online cancer survivor community.

    Science.gov (United States)

    Portier, Kenneth; Greer, Greta E; Rokach, Lior; Ofek, Nir; Wang, Yafei; Biyani, Prakhar; Yu, Mo; Banerjee, Siddhartha; Zhao, Kang; Mitra, Prasenjit; Yen, John

    2013-12-01

    Online cancer communities help members support one another, provide new perspectives about living with cancer, normalize experiences, and reduce isolation. The American Cancer Society's 166000-member Cancer Survivors Network (CSN) is the largest online peer support community for cancer patients, survivors, and caregivers. Sentiment analysis and topic modeling were applied to CSN breast and colorectal cancer discussion posts from 2005 to 2010 to examine how sentiment change of thread initiators, a measure of social support, varies by discussion topic. The support provided in CSN is highest for medical, lifestyle, and treatment issues. Threads related to 1) treatments and side effects, surgery, mastectomy and reconstruction, and decision making for breast cancer, 2) lung scans, and 3) treatment drugs in colon cancer initiate with high negative sentiment and produce high average sentiment change. Using text mining tools to assess sentiment, sentiment change, and thread topics provides new insights that community managers can use to facilitate member interactions and enhance support outcomes.

  6. An author topic analysis of tobacco regulation investigators.

    Science.gov (United States)

    Li, Ding Cheng; Okamoto, Janet; Leischow, Scott; Liu, Hongfang

    2014-01-01

    To facilitate the implementation of the Family Smoking Prevention and Tobacco Control Act of 2009, the Federal Drug Agency (FDA) Center for Tobacco Products (CTP) has identified research priorities under the umbrella of tobacco regulatory science (TRS). As a newly introduced field, the current landscape of TRS research is unclear. In this work, we conducted a bibliometric study of TRS research by applying author topic modeling on MEDLINE citations published by currently-funded TRS principle investigators. Our initial results show that author topic modeling can address the issue of research interests reasonably. Furthermore, a network involving authors, topics and words can be established for more detailed bibliometric analysis. This network may also be useful to grantees and funding administrators in suggesting potential collaborators or identifying those that share common research interests for data harmonization or other purposes.

  7. Nigeria Journal of Pure and Applied Physics

    African Journals Online (AJOL)

    Nigeria Journal of Pure and Applied Physics publishes papers of the highest quality and significance in specific areas of physics, pure and applied, as listed below. The journal content reflects core physics disciplines, but is also open to a broad range of topics whose central theme falls within the bounds of physics.

  8. Journal of Applied Science and Technology: Submissions

    African Journals Online (AJOL)

    Author Guidelines. AIMS & SCOPE. The Journal of Applied Science and Technology (JAST) seeks to promote and disseminate knowledge of various research topics in the applied sciences which address issues of technological developments in the Tropics. GUIDELINES FOR AUTHORS. 1. All submissions to the Journal of ...

  9. THE TECHNOLOGY OF MANAGEMENT OF FORMATION OF STUDENTS’ PROFESSIONAL INTERESTS

    Directory of Open Access Journals (Sweden)

    Anna Leonidovna Nemykina

    2014-10-01

    Full Text Available The article discusses the technological approach to the formation and development of the students’ professional interests at universities. Based on the analysis of fundamental works of Russian scientists the concepts of "interest", "professional interest" were analyzed. The author developed the structural scheme of the technology of management of the professional interests formation and levels of their development. The essential characteristics of these levels were determined in the article. Conclusion of the article is the position that the consecutive passing of motivational and target, activity, adaptive, self-reflexive-identification levels contributes to the formation of professional interest. Article can be used in empirical research on the analyzed topic.

  10. Recent advances and applications of probabilistic topic models

    Science.gov (United States)

    Wood, Ian

    2014-12-01

    I present here an overview of recent advances in probabilistic topic modelling and related Bayesian graphical models as well as some of their more atypical applications outside of their home: text analysis. These techniques allow the modelling of high dimensional count vectors with strong correlations. With such data, simply calculating a correlation matrix is infeasible. Probabilistic topic models address this using mixtures of multinomials estimated via Bayesian inference with Dirichlet priors. The use of conjugate priors allows for efficient inference, and these techniques scale well to data sets with many millions of vectors. The first of these techniques to attract significant attention was Latent Dirichlet Allocation (LDA) [1, 2]. Numerous extensions and adaptations of LDA have been proposed: non-parametric models; assorted models incorporating authors, sentiment and other features; models regularised through the use of extra metadata or extra priors on topic structure, and many more [3]. They have become widely used in the text analysis and population genetics communities, with a number of compelling applications. These techniques are not restricted to text analysis, however, and can be applied to other types of data which can be sensibly discretised and represented as counts of labels/properties/etc. LDA and it's variants have been used to find patterns in data from diverse areas of inquiry, including genetics, plant physiology, image analysis, social network analysis, remote sensing and astrophysics. Nonetheless, it is relatively recently that probabilistic topic models have found applications outside of text analysis, and to date few such applications have been considered. I suggest that there is substantial untapped potential for topic models and models inspired by or incorporating topic models to be fruitfully applied, and outline the characteristics of systems and data for which this may be the case.

  11. Redundancy-aware topic modeling for patient record notes.

    Directory of Open Access Journals (Sweden)

    Raphael Cohen

    Full Text Available The clinical notes in a given patient record contain much redundancy, in large part due to clinicians' documentation habit of copying from previous notes in the record and pasting into a new note. Previous work has shown that this redundancy has a negative impact on the quality of text mining and topic modeling in particular. In this paper we describe a novel variant of Latent Dirichlet Allocation (LDA topic modeling, Red-LDA, which takes into account the inherent redundancy of patient records when modeling content of clinical notes. To assess the value of Red-LDA, we experiment with three baselines and our novel redundancy-aware topic modeling method: given a large collection of patient records, (i apply vanilla LDA to all documents in all input records; (ii identify and remove all redundancy by chosing a single representative document for each record as input to LDA; (iii identify and remove all redundant paragraphs in each record, leaving partial, non-redundant documents as input to LDA; and (iv apply Red-LDA to all documents in all input records. Both quantitative evaluation carried out through log-likelihood on held-out data and topic coherence of produced topics and qualitative assessment of topics carried out by physicians show that Red-LDA produces superior models to all three baseline strategies. This research contributes to the emerging field of understanding the characteristics of the electronic health record and how to account for them in the framework of data mining. The code for the two redundancy-elimination baselines and Red-LDA is made publicly available to the community.

  12. Facing the Future: Slovenian Armed Forces Officer Corps and Professionalism

    Science.gov (United States)

    2011-12-16

    officer corps, jurisdiction, officer education, professional authonomy, civil-military relations, operational enviroment 16. SECURITY CLASSIFICATION OF...expressed in SAOC? Definitions Ethics. “Values, norms , and symbols regulating the behavior of the professional toward his client, public, and... management techniques in the military as they can have a disastrous effect on unit coherence and officer professionalism. If not applied correctly and

  13. Teachers’ professional development needs in data handling and probability

    Directory of Open Access Journals (Sweden)

    Helena Wessels

    2011-10-01

    Full Text Available Poor Trends in International Mathematics and Science Study (TIMMS results and widespread disappointing mathematics results in South Africa necessitate research-based and more efficient professional development for in-service mathematics teachers. This article reports on the profiling of mathematics teachers’ statistical knowledge, beliefs and confidence in order to inform the development of in-service teacher education programmes in statistics for Grade 8 and Grade 9 teachers. Ninety mathematics teachers from schools with culturally diverse learner populations in an urban region in South Africa were profiled using an adapted profiling instrument (Watson, 2001. Although statistics formed part of quite a number of these teachers’ initial teacher education and about half of them were involved in professional development in statistics education, they still teach traditionally, rather than using a more data driven approach. Teachers indicated high levels of confidence in teaching most statistics topics but showed low levels of statistical thinking when they had to apply their knowledge of concepts, such as sample and average in social contexts including newspaper articles and research reports.

  14. Applied systems theory

    CERN Document Server

    Dekkers, Rob

    2017-01-01

    Offering an up-to-date account of systems theories and its applications, this book provides a different way of resolving problems and addressing challenges in a swift and practical way, without losing overview and grip on the details. From this perspective, it offers a different way of thinking in order to incorporate different perspectives and to consider multiple aspects of any given problem. Drawing examples from a wide range of disciplines, it also presents worked cases to illustrate the principles. The multidisciplinary perspective and the formal approach to modelling of systems and processes of ‘Applied Systems Theory’ makes it suitable for managers, engineers, students, researchers, academics and professionals from a wide range of disciplines; they can use this ‘toolbox’ for describing, analysing and designing biological, engineering and organisational systems as well as getting a better understanding of societal problems. This revised, updated and expanded second edition includes coverage of a...

  15. Exploiting topic modeling to boost metagenomic reads binning.

    Science.gov (United States)

    Zhang, Ruichang; Cheng, Zhanzhan; Guan, Jihong; Zhou, Shuigeng

    2015-01-01

    With the rapid development of high-throughput technologies, researchers can sequence the whole metagenome of a microbial community sampled directly from the environment. The assignment of these metagenomic reads into different species or taxonomical classes is a vital step for metagenomic analysis, which is referred to as binning of metagenomic data. In this paper, we propose a new method TM-MCluster for binning metagenomic reads. First, we represent each metagenomic read as a set of "k-mers" with their frequencies occurring in the read. Then, we employ a probabilistic topic model -- the Latent Dirichlet Allocation (LDA) model to the reads, which generates a number of hidden "topics" such that each read can be represented by a distribution vector of the generated topics. Finally, as in the MCluster method, we apply SKWIC -- a variant of the classical K-means algorithm with automatic feature weighting mechanism to cluster these reads represented by topic distributions. Experiments show that the new method TM-MCluster outperforms major existing methods, including AbundanceBin, MetaCluster 3.0/5.0 and MCluster. This result indicates that the exploitation of topic modeling can effectively improve the binning performance of metagenomic reads.

  16. Identifying Topics in Microblogs Using Wikipedia.

    Science.gov (United States)

    Yıldırım, Ahmet; Üsküdarlı, Suzan; Özgür, Arzucan

    2016-01-01

    Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA), propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s) the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision) and other observations from the study are discussed in detail.

  17. Identifying Topics in Microblogs Using Wikipedia.

    Directory of Open Access Journals (Sweden)

    Ahmet Yıldırım

    Full Text Available Twitter is an extremely high volume platform for user generated contributions regarding any topic. The wealth of content created at real-time in massive quantities calls for automated approaches to identify the topics of the contributions. Such topics can be utilized in numerous ways, such as public opinion mining, marketing, entertainment, and disaster management. Towards this end, approaches to relate single or partial posts to knowledge base items have been proposed. However, in microblogging systems like Twitter, topics emerge from the culmination of a large number of contributions. Therefore, identifying topics based on collections of posts, where individual posts contribute to some aspect of the greater topic is necessary. Models, such as Latent Dirichlet Allocation (LDA, propose algorithms for relating collections of posts to sets of keywords that represent underlying topics. In these approaches, figuring out what the specific topic(s the keyword sets represent remains as a separate task. Another issue in topic detection is the scope, which is often limited to specific domain, such as health. This work proposes an approach for identifying domain-independent specific topics related to sets of posts. In this approach, individual posts are processed and then aggregated to identify key tokens, which are then mapped to specific topics. Wikipedia article titles are selected to represent topics, since they are up to date, user-generated, sophisticated articles that span topics of human interest. This paper describes the proposed approach, a prototype implementation, and a case study based on data gathered during the heavily contributed periods corresponding to the four US election debates in 2012. The manually evaluated results (0.96 precision and other observations from the study are discussed in detail.

  18. Topics in Number Theory Conference

    CERN Document Server

    Andrews, George; Ono, Ken

    1999-01-01

    From July 31 through August 3,1997, the Pennsylvania State University hosted the Topics in Number Theory Conference. The conference was organized by Ken Ono and myself. By writing the preface, I am afforded the opportunity to express my gratitude to Ken for beng the inspiring and driving force behind the whole conference. Without his energy, enthusiasm and skill the entire event would never have occurred. We are extremely grateful to the sponsors of the conference: The National Sci­ ence Foundation, The Penn State Conference Center and the Penn State Depart­ ment of Mathematics. The object in this conference was to provide a variety of presentations giving a current picture of recent, significant work in number theory. There were eight plenary lectures: H. Darmon (McGill University), "Non-vanishing of L-functions and their derivatives modulo p. " A. Granville (University of Georgia), "Mean values of multiplicative functions. " C. Pomerance (University of Georgia), "Recent results in primality testing. " C. ...

  19. Topical absorption and systemic toxicity.

    Science.gov (United States)

    Alikhan, Fatima Sasha; Maibach, Howard

    2011-09-01

    Dermal absorption of some chemicals and drugs can cause systemic toxicity. We evaluated several case reports from the past decade, which discuss the dermal absorption of a specific chemical and potential local and systemic effects. We focused on herbicide and pesticide exposure along with exposure to cutaneous medication, occupational contact, and cosmeceutical exposure. Although causality cannot be established in most cases, it is critical to be aware of the possible effects of topical absorption that may not be immediately apparent. We recommended further studies on specific chemicals to ascertain causality and determine the highest exposure level with no observed adverse affect level (NOAEL) and the reference dose (RfD). Post-marketing epidemiology data in most geographical areas are markedly limited. A weak link in public health resides in the inadequate reporting and workup of alleged chemically related adverse effects. This arena mandates a re-thinking of how to increase this reporting, and workup, as a backup to our preclinical and clinical studies. Public awareness and funding will be rewarded by increased evidence to backup pre-approval pre-marketing studies.

  20. Decision Point 1 Topical Report

    Energy Technology Data Exchange (ETDEWEB)

    Yablonsky, Al; Barsoumian, Shant; Legere, David

    2013-05-01

    This Topical Report addresses accomplishments achieved during Phase 2a of the SkyMine® Carbon Mineralization Pilot Project. The primary objectives of this project are to design, construct, and operate a system to capture CO2 from a slipstream of flue gas from a commercial coal-fired cement kiln, convert that CO2 to products having commercial value (i.e., beneficial use), show the economic viability of the CO2 capture and conversion process, and thereby advance the technology to the point of readiness for commercial scale demonstration and proliferation. The overall process is carbon negative, resulting in mineralization of CO2 that would otherwise be released into the atmosphere. The project will also substantiate market opportunities for the technology by sales of chemicals into existing markets, and identify opportunities to improve technology performance and reduce costs at the commercial scale. The project is being conducted in two phases. The primary objectives of Phase 1 were to elaborate proven SkyMine® process chemistry to commercial pilot-scale operation and complete the preliminary design for the pilot plant to be built and operated in Phase 2, complete a NEPA evaluation, and develop a comprehensive carbon life cycle analysis. The objective of the current Phase (2a) is to complete the detailed design of the pilot plant to be built in Phase 2b.

  1. TOPICAL REVIEW: Double beta decay

    Science.gov (United States)

    Faessler, Amand; Simkovic, Fedor

    1998-12-01

    We review the recent developments in the field of nuclear double beta decay, which is presently an important topic in both nuclear and particle physics. The mechanism of lepton number violation within the neutrinoless double beta decay (0954-3899/24/12/001/img5-decay) is discussed in the context of the problem of neutrino mixing and the R-parity violating supersymmetric extensions of the standard model. The problem of reliable determination of the nuclear matrix elements governing both two-neutrino and neutrinoless modes of the double beta decay is addressed. The validity of different approximation schemes in the considered nuclear structure studies is analysed and the role of the Pauli exclusion principle for a correct treatment of nuclear matrix elements is emphasized. The constraints on different lepton-number violating parameters such as effective electron neutrino mass, effective right-handed weak interaction parameters, effective Majoron coupling constant and R-parity violating SUSY parameters are derived from the best presently available experimental limits on the half-life of 0954-3899/24/12/001/img5-decay.

  2. Towards professionalism in agricultural extension: The professional ...

    African Journals Online (AJOL)

    Towards professionalism in agricultural extension: The professional registration of Extensionists in South Africa – A dream or a reality? The role of the South African Society of Extensionists in South Africa – A dream or a reality? The role of the South African Society of Agricultural Extension (SASAE)

  3. Professional development of distance education professionals ...

    African Journals Online (AJOL)

    Erna Kinsey

    Professional development of distance education professionals (DEPs) at TSA: a profile of functions. J.F. van Koller. Institute for Staff Development, Technikon SA, Private Bag X6, Florida, 1710 South Africa jvcoller@tsa.ac.za. This article deals with the development of a profile of the functions and required competencies of ...

  4. Teacher Professionalism: Analysis of Professionalism Phases

    Science.gov (United States)

    Wardoyo, Cipto; Herdiani, Aulia; Sulikah

    2017-01-01

    Teacher professionalism has become a distinctive concern in educational discussions. Based on Teacher and Lecturer Act No.14 2005 carried out by Indonesian Government, teacher professionalism, considered as an assessment aspect of teacher quality, could be drawn by four competences, pedagogical competence, personal, competence, social competence,…

  5. Professional Environment for Teacher Professional Development

    Science.gov (United States)

    Zascerinska, Jelena

    2010-01-01

    Introduction. Teaching and training are at the heart of the knowledge society where the continuing professional development of teachers and trainers provides the cornerstone for the development of a high quality education and training systems. The Aim of the Study. To identify a design of professional environment for teacher professional…

  6. Transforming Professional Development to Professional Learning

    Science.gov (United States)

    Stewart, Chelsea

    2014-01-01

    This article reviews teacher professional development norms as they are shifting toward collaborative practice. It is posed that passive and individual practices are inadequate to prepare teachers to integrate the academic skills that learners need for both workforce and college readiness. Promising practices in professional development are…

  7. Professional Development Plus: Rethinking Professional Learning

    Science.gov (United States)

    Hudak, Michele

    2013-01-01

    The purpose of professional development is to enhance educator practices so that students may achieve at high levels. Too often, professional development tends to be too broad, general, or unrelated to problems of practice that teachers face in their own classrooms. This action research project builds upon the scholarly research that recognizes…

  8. Enhancing the Undergraduate Industrial Engineering Curriculum: Defining Desired Characteristics and Emerging Topics

    Science.gov (United States)

    Eskandari, Hamidreza; Sala-Diakanda, Serge; Furterer, Sandra; Rabelo, Luis; Crumpton-Young, Lesia; Williams, Kent

    2007-01-01

    Purpose: This paper aims to present the results of an initial research study conducted to identify the desired professional characteristics of an industrial engineer with an undergraduate degree and the emerging topic areas that should be incorporated into the curriculum to prepare industrial engineering (IE) graduates for the future workforce.…

  9. Percolation, SLE and related topics

    CERN Document Server

    Kreimer, Dirk; Renormalization and universality in mathematical physics

    2007-01-01

    This book covers a wide range of phenomena in the natural sciences dominated by notions of universality and renormalization. The contributions in this volume are equally broad in their approach to these phenomena, offering the mathematical as well as the perspective of the applied sciences. They explore renormalization theory in quantum field theory and statistical physics, and its connections to modern mathematics as well as physics on scales from the microscopic to the macroscopic.

  10. Recent Advances In Topical Therapy In Dermatology

    Directory of Open Access Journals (Sweden)

    Mohan Thappa Devinder

    2003-01-01

    Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

  11. HierarchicalTopics: visually exploring large text collections using topic hierarchies.

    Science.gov (United States)

    Dou, Wenwen; Yu, Li; Wang, Xiaoyu; Ma, Zhiqiang; Ribarsky, William

    2013-12-01

    Analyzing large textual collections has become increasingly challenging given the size of the data available and the rate that more data is being generated. Topic-based text summarization methods coupled with interactive visualizations have presented promising approaches to address the challenge of analyzing large text corpora. As the text corpora and vocabulary grow larger, more topics need to be generated in order to capture the meaningful latent themes and nuances in the corpora. However, it is difficult for most of current topic-based visualizations to represent large number of topics without being cluttered or illegible. To facilitate the representation and navigation of a large number of topics, we propose a visual analytics system--HierarchicalTopic (HT). HT integrates a computational algorithm, Topic Rose Tree, with an interactive visual interface. The Topic Rose Tree constructs a topic hierarchy based on a list of topics. The interactive visual interface is designed to present the topic content as well as temporal evolution of topics in a hierarchical fashion. User interactions are provided for users to make changes to the topic hierarchy based on their mental model of the topic space. To qualitatively evaluate HT, we present a case study that showcases how HierarchicalTopics aid expert users in making sense of a large number of topics and discovering interesting patterns of topic groups. We have also conducted a user study to quantitatively evaluate the effect of hierarchical topic structure. The study results reveal that the HT leads to faster identification of large number of relevant topics. We have also solicited user feedback during the experiments and incorporated some suggestions into the current version of HierarchicalTopics.

  12. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus

    National Research Council Canada - National Science Library

    Elsaie, Lotfy; El Mohsen, Abdelaraouf; Ibrahim, Ibrahim; Mohey-Eddin, Mahmoud; Elsaie, Mohamed

    2016-01-01

    .... Peppermint oil can be effective in reducing the severity of such a condition.Aim: The aim of this study was to assess the efficacy of topically applied peppermint oil in the treatment of chronic...

  13. The Brazilian Football Association (CBF) model for epidemiological studies on professional soccer player injuries

    Science.gov (United States)

    Arliani, Gustavo Gonçalves; Belangero, Paulo Santoro; Runco, Jose Luiz; Cohen, Moisés

    2011-01-01

    OBJECTIVE: This study aims to establish a national methodological model for epidemiological studies on professional soccer player injuries and to describe the numerous relevant studies previously published on this topic. INTRODUCTION: The risk of injury in professional soccer is high. However, previous studies of injury risk in Brazil and other countries have been characterized by large variations in study design and data collection methods as well as definitions of injury, standardized diagnostic criteria, and recovery times. METHODS: A system developed by the Union of European Football for epidemiological studies on professional soccer players is being used as a starting point to create a methodological model for the Brazilian Football Association. To describe the existing studies on professional soccer player injuries, we developed a search strategy to identify relevant epidemiological studies. We included the Latin American and Caribbean Center on Health Sciences and Medline databases in our study. RESULTS: We considered 60 studies from Medline and 16 studies from the Latin American and Caribbean Center on Health Sciences in the final analysis. Twelve studies were selected for final inclusion in this review: seven from the Latin American and Caribbean Center on Health Sciences and five from Medline. We identified a lack of uniformity in the study design, data collection methods, injury definitions, standardized diagnostic criteria, and the definition of recovery time. Based on the information contained within these articles, we developed a model for epidemiological studies for the Brazilian Football Association. CONCLUSIONS: There is no uniform model for epidemiological studies of professional soccer injuries. Here, we propose a novel model to be applied for epidemiological studies of professional soccer player injuries in Brazil and throughout the world. PMID:22012041

  14. The Brazilian Football Association (CBF model for epidemiological studies on professional soccer player injuries

    Directory of Open Access Journals (Sweden)

    Gustavo Goncalves Arliani

    2011-01-01

    Full Text Available OBJECTIVE: This study aims to establish a national methodological model for epidemiological studies on professional soccer player injuries and to describe the numerous relevant studies previously published on this topic. INTRODUCTION: The risk of injury in professional soccer is high. However, previous studies of injury risk in Brazil and other countries have been characterized by large variations in study design and data collection methods as well as definitions of injury, standardized diagnostic criteria, and recovery times. METHODS: A system developed by the Union of European Football for epidemiological studies on professional soccer players is being used as a starting point to create a methodological model for the Brazilian Football Association. To describe the existing studies on professional soccer player injuries, we developed a search strategy to identify relevant epidemiological studies. We included the Latin American and Caribbean Center on Health Sciences and Medline databases in our study. RESULTS: We considered 60 studies from Medline and 16 studies from the Latin American and Caribbean Center on Health Sciences in the final analysis. Twelve studies were selected for final inclusion in this review: seven from the Latin American and Caribbean Center on Health Sciences and five from Medline. We identified a lack of uniformity in the study design, data collection methods, injury definitions, standardized diagnostic criteria, and the definition of recovery time. Based on the information contained within these articles, we developed a model for epidemiological studies for the Brazilian Football Association. CONCLUSIONS: There is no uniform model for epidemiological studies of professional soccer injuries. Here, we propose a novel model to be applied for epidemiological studies of professional soccer player injuries in Brazil and throughout the world.

  15. Preface to Special Topic: Acoustic Metamaterials and Metasurfaces

    Science.gov (United States)

    Assouar, Badreddine

    2018-03-01

    The advent of acoustic metamaterials in the beginning of 2000s and very recently of acoustic metasurfaces has created tremendous excitement and efforts in the field of materials science and physics by introducing and building real transformative research and dealing with unprecedented physics and applications. The acoustic/elastic metamaterials and metasurfaces, which can simply be described as designed artificial materials with unusual physical properties, form the core of the present Special Topic published by the Journal of Applied Physics.

  16. How to perform a critically appraised topic: part 2, appraise, evaluate, generate, and recommend.

    Science.gov (United States)

    Kelly, Aine Marie; Cronin, Paul

    2011-11-01

    This article continues the discussion of a critically appraised topic started in Part 1. A critically appraised topic is a practical tool for learning and applying critical appraisal skills. This article outlines steps 4-7 involved in performing a critically appraised topic for studies of diagnostic tests: Appraise, Appraise the literature; Evaluate, evaluate the strength of the evidence from the literature; Generate, generate graphs of conditional probability; and Recommend, draw conclusions and make recommendations. For steps 4-7 of performing a critically appraised topic, the main study results are summarized and translated into clinically useful measures of accuracy, efficacy, or risk.

  17. Identifying Health-Related Topics on Twitter

    Science.gov (United States)

    Prier, Kyle W.; Smith, Matthew S.; Giraud-Carrier, Christophe; Hanson, Carl L.

    Public health-related topics are difficult to identify in large conversational datasets like Twitter. This study examines how to model and discover public health topics and themes in tweets. Tobacco use is chosen as a test case to demonstrate the effectiveness of topic modeling via LDA across a large, representational dataset from the United States, as well as across a smaller subset that was seeded by tobacco-related queries. Topic modeling across the large dataset uncovers several public health-related topics, although tobacco is not detected by this method. However, topic modeling across the tobacco subset provides valuable insight about tobacco use in the United States. The methods used in this paper provide a possible toolset for public health researchers and practitioners to better understand public health problems through large datasets of conversational data.

  18. Communicating with Professionals

    Medline Plus

    Full Text Available ... with your healthcare team about your concerns, asking questions and getting the facts. Usually, office visits and ... or other healthcare professionals. Find a list of questions to ask at your next appointment . Healthcare professionals ...

  19. Communicating with Professionals

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Communicating with Professionals Updated:Oct 3,2016 After a cardiac event ... Medicines - Medicine Assistance Programs - Medicine Checklist - Medication Tracker ... with Professionals - Introduction - Preparing for Medical Visits - Questions To Ask ...

  20. Communicating with Healthcare Professionals

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Communicating with Professionals Updated:Oct 3,2016 After a cardiac event ... Medicines - Medicine Assistance Programs - Medicine Checklist - Medication Tracker ... with Professionals - Introduction - Preparing for Medical Visits - Questions To Ask ...

  1. Tracking topic birth and death in LDA.

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Andrew T.; Robinson, David Gerald

    2011-09-01

    Most topic modeling algorithms that address the evolution of documents over time use the same number of topics at all times. This obscures the common occurrence in the data where new subjects arise and old ones diminish or disappear entirely. We propose an algorithm to model the birth and death of topics within an LDA-like framework. The user selects an initial number of topics, after which new topics are created and retired without further supervision. Our approach also accommodates many of the acceleration and parallelization schemes developed in recent years for standard LDA. In recent years, topic modeling algorithms such as latent semantic analysis (LSA)[17], latent Dirichlet allocation (LDA)[10] and their descendants have offered a powerful way to explore and interrogate corpora far too large for any human to grasp without assistance. Using such algorithms we are able to search for similar documents, model and track the volume of topics over time, search for correlated topics or model them with a hierarchy. Most of these algorithms are intended for use with static corpora where the number of documents and the size of the vocabulary are known in advance. Moreover, almost all current topic modeling algorithms fix the number of topics as one of the input parameters and keep it fixed across the entire corpus. While this is appropriate for static corpora, it becomes a serious handicap when analyzing time-varying data sets where topics come and go as a matter of course. This is doubly true for online algorithms that may not have the option of revising earlier results in light of new data. To be sure, these algorithms will account for changing data one way or another, but without the ability to adapt to structural changes such as entirely new topics they may do so in counterintuitive ways.

  2. Health Screening: MedlinePlus Health Topic

    Science.gov (United States)

    ... for You (Mayo Foundation for Medical Education and Research) TB Screening Tests (American Association for Clinical Chemistry) Genetics Genetic Testing: MedlinePlus Health Topic (National Library ...

  3. Topical Antimicrobial Therapy for Treating Chronic Wounds

    National Research Council Canada - National Science Library

    Benjamin A. Lipsky; Christopher Hoey

    2009-01-01

    .... Topical therapy affords many potential advantages but also has disadvantages. Opinions differ on which clinical signs define wound infection and on whether quantitative microbiological studies are useful...

  4. Topical anesthetics for cosmetic and laser dermatology.

    Science.gov (United States)

    Amin, Snehal P; Goldberg, David J

    2005-01-01

    Many effective and simple topical anesthetic products are available today and commonly used in medical and non-medical settings. The increased use of topical anesthetics, especially by non-physicians in the medical and non-medical settings, has resulted in increased rates of complications including ineffective anesthesia, allergy, and even potential fatalities. This review focuses on various techniques and formulations for topical anesthesia and their appropriate applications in cosmetic and laser dermatology. In addition, the history, pharmacology, and clinical complications of topical anesthetics are discussed.

  5. Updates of Topical and Local Anesthesia Agents.

    Science.gov (United States)

    Boyce, Ricardo A; Kirpalani, Tarun; Mohan, Naveen

    2016-04-01

    As described in this article, there are many advances in topical and local anesthesia. Topical and local anesthetics have played a great role in dentistry in alleviating the fears of patients, eliminating pain, and providing pain control. Many invasive procedures would not be performed without the use and advances of topical/local anesthetics. The modern-day dentist has the responsibility of knowing the variety of products on the market and should have at least references to access before, during, and after treatment. This practice ensures proper care with topical and local anesthetics for the masses of patients entering dental offices worldwide. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. The treatment of rosacea with topical ivermectin.

    Science.gov (United States)

    Ali, S T; Alinia, H; Feldman, S R

    2015-04-01

    The treatment of rosacea is challenging because several pathophysiologic processes may be involved, including neurovascular dysregulation and alterations in innate immune status. Demodex mites may play a role in the latter mechanism. Topical ivermectin is a new therapeutic modality which demonstrates antiparasitic and anti-inflammatory properties. This article reviews published evidence related to the efficacy and safety of topical ivermectin. PubMed was utilized to search for key words "topical ivermectin", "ivermectin cream" and "rosacea". Three clinical trials were found that studied topical ivermectin as a treatment option for rosacea. Ivermectin was effective, safe and well tolerated. Copyright 2015 Prous Science, S.A.U. or its licensors. All rights reserved.

  7. Topical tacrolimus as treatment of atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Masutaka Furue

    2009-11-01

    Full Text Available Masutaka Furue, Satoshi TakeuchiDepartment of Dermatology, Faculty of Medical Sciences, Kyushu University, Fukuoka, JapanAbstract: Atopic dermatitis (AD is a common, chronic, relapsing, severely pruritic, eczematous skin disease. The mainstays of treatment for AD are topical tacrolimus and topical steroids. Tacrolimus, a calcineurin inhibitor, not only complements existing treatment options but also overcomes some of the drawbacks of topical steroid therapy when given topically and thus meets the long-term needs of patients in preventing disease progression. Topical tacrolimus has been widely recognized in terms of its short- and long-term efficacies and safety, and it is also accepted as a first-line treatment for inflammation in AD. The recent proactive use of topical tacrolimus may emphasize a long-term benefit of this calcineurin inhibitor for AD treatment. To reduce possible long-term adverse effects, it is important to monitor its topical doses in daily clinics.Keywords: atopic dermatitis, topical tacrolimus, topical steroids, dose, proactive use, adverse effects

  8. Topics in Extended Dynamical Systems

    Science.gov (United States)

    Bhagavatula, Ravi S.

    This thesis consists of three chapters. Each chapter is self-contained and is devoted to the investigation of a particular topic in extended dynamical systems. In the first chapter, an approach based on Langevin equations is implemented to understand the non-Gaussian nature of the probability distribution function (PDF) of local diffusive variables in extended dynamical systems, e.g., a passive scalar advected by turbulent velocity fluctuations. Two mechanisms are proposed for the origin of non-Gaussian tails: One relies on the nature of temporal correlations of the fluctuations that couple additively to the diffusive field, leading to exponential and stretched exponential tails in the PDF; the other depends on multiplicative coupling between the diffusive field and the fluctuations, producing algebraic tails in the PDF. The mechanisms are illustrated using models for a passive scalar and also a current driven Josephson junction array. This study indicates that shapes of local PDFs in turbulent states are non-universal and crucially depend on local couplings and time scales. The second chapter establishes the existence of a class of locally conserving chaotic (deterministic) systems that exhibit Generic Scale Invariance--algebraic decay of spatial and temporal correlations without tuning parameters. This study also reveals the similarity between noise and chaos in extended systems as far as long-wavelength and long -time behavior is concerned. Specifically, a two dimensional coupled-map lattice model with a conserved density is numerically shown to exhibit, in agreement with heuristic arguments, algebraic decay of spatio-temporal correlations in chaotic states with simple predictable exponents. The third chapter investigates scaling behavior of earthquakes in seismic zone models in which an earthquake is modeled by a quasi-static description that ignores short -time dynamics during an earthquake. The models incorporate the essential feature of long-ranged stress

  9. Topics in Gravitation and Cosmology

    Science.gov (United States)

    Bahrami Taghanaki, Sina

    This thesis is focused on two topics in which relativistic gravitational fields play an important role, namely early Universe cosmology and black hole physics. The theory of cosmic inflation has emerged as the most successful theory of the very early Universe with concrete and verifiable predictions for the properties of anisotropies of the cosmic microwave background radiation and large scale structure. Coalescences of black hole binaries have recently been detected by the Laser Interferometer Gravitational Wave Observatory (LIGO), opening a new arena for observationally testing the dynamics of gravity. In part I of this thesis we explore some modifications to the standard theory of inflation. The main predictions of single field slow-roll inflation have been largely consistent with cosmological observations. However, there remain some aspects of the theory that are not presently well understood. Among these are the somewhat interrelated issues of the choice of initial state for perturbations and the potential imprints of pre-inflationary dynamics. It is well known that a key prediction of the standard theory of inflation, namely the Gaussianity of perturbations, is a consequence of choosing a natural vacuum initial state. In chapter 3, we study the generation and detectability of non-Gaussianities in inflationary scalar perturbations that originate from more general choices of initial state. After that, in chapter 4, we study a simple but predictive model of pre-inflationary dynamics in an attempt to test the robustness of inflationary predictions. We find that significant deviations from the standard predictions are unlikely to result from models in which the inflaton field decouples from the pre-inflationary degrees of freedom prior to freeze-out of the observable modes. In part II we turn to a study of an aspect of the thermodynamics of black holes, a subject which has led to important advances in our understanding of quantum gravity. For objects which

  10. Professionalism in Dance Education

    Science.gov (United States)

    Koff, Susan R.; Mistry, Gianna Limone

    2012-01-01

    Professionalism in Dance Education is a complex construction. It can be imposed from the outside (degree completed, job status, salary) or can be identified from the professional herself. Seven graduate dance education students were interviewed with specific focus on the transition from student to professional and the feelings surrounding this…

  11. Professional Development. Issue Brief

    Science.gov (United States)

    Keleher, Julia

    2017-01-01

    In this professional development research brief, the author sets forth the overarching considerations that should be kept in mind when conceptualizing professional development for educators working with neglected or delinquent youth (N or D). The brief begins by defining professional development and demonstrating why it is a critical support for…

  12. Topical therapy of recurrent herpes - acyclovir versus tromantidine

    Directory of Open Access Journals (Sweden)

    Kumar Bhushan

    1991-01-01

    Full Text Available Fifty men with recurrent genital herpes were treated with either acyclovir 5% cream or tromantidine 1 % ointment applied topically. Acyclovir cream was applied 5 times and tromantidine cream 4 times daily for 5 days. At least one pre-treatment episode was observed by one of the authors. Self assessment charts were provided to the patients to record prodromal symptoms and healing time. For comparison at least 3 post treatment episodes were observed and com-pared with mean healing time of 3 pre-treatment episodes. Both acyclovir cream and tromantidine ointment significantly reduced the duration of prodrome, hastened healing and so reduced mean healing time.

  13. Topics in quaternion linear algebra

    CERN Document Server

    Rodman, Leiba

    2014-01-01

    Quaternions are a number system that has become increasingly useful for representing the rotations of objects in three-dimensional space and has important applications in theoretical and applied mathematics, physics, computer science, and engineering. This is the first book to provide a systematic, accessible, and self-contained exposition of quaternion linear algebra. It features previously unpublished research results with complete proofs and many open problems at various levels, as well as more than 200 exercises to facilitate use by students and instructors. Applications presented in the book include numerical ranges, invariant semidefinite subspaces, differential equations with symmetries, and matrix equations. Designed for researchers and students across a variety of disciplines, the book can be read by anyone with a background in linear algebra, rudimentary complex analysis, and some multivariable calculus. Instructors will find it useful as a complementary text for undergraduate linear algebra courses...

  14. Special topics in international adoption.

    Science.gov (United States)

    Jenista, Jerri Ann

    2005-10-01

    As international adoption has become more "mainstream," the issues recently addressed in domestic adoption have become more important in adoptions involving children originating in other countries. Certain groups of prospective adoptive parents, such as gay or lesbian couples, single parents, and parents with disabilities, have begun to apply to adopt in ever increasing numbers. Children who may have been considered unadoptable in the past are now routinely being offered to prospective adoptive parents. The numbers and ages of the children placed and the spacing between adoptions have come under scrutiny. The rates of adoption dissolutions and disruptions are being examined carefully by the receiving and sending countries. There is a pressing need for research into numerous social aspects of adoption.

  15. Alkali-soluble fluoride deposition on enamel after professional application of topical fluoride in vitro Formação de flúor fracamente ligado ao esmalte após a aplicação tópica profissional de flúor in vitro

    Directory of Open Access Journals (Sweden)

    Mitsue Fujimaki Hayacibara

    2004-03-01

    Full Text Available Since the efficacy of topical fluoride products is related to the fluoride (F availability and its reactivity with enamel, this study was conducted. The F concentration of the following materials was verified: I- acidulated phosphate fluoride (APF gel (1.23% F, II- APF foam (1.23% F and III- Varnish (2.26% F. Forty blocks of bovine enamel were divided into 4 groups and treated according to the materials described, being one of them used as control. Loosely bound fluoride (''CaF2'' was determined on enamel after extraction with 1.0M KOH and analyzed by ion-selective electrode. Total F concentration found in gel was 12,642, in foam 12,755 and in varnish 23,183 mg F/g. All products formed statistically higher amounts of ''CaF2'' on enamel compared to the control group (p 0.05. Thus, ''CaF2'' formation was not proportional to the total F content in the products, suggesting that the pH and the vehicle used are more important.Considerando que a eficácia dos produtos para aplicação tópica profissional de flúor (géis, espumas e vernizes está relacionada com a reatividade do flúor (F com o esmalte e sendo esta dependente da disponibilidade do F em cada produto, este estudo foi conduzido. A concentração de F nos seguintes produtos foi estudada: I - Flúor Fosfato Acidulado (FFA gel (1,23% F, II - FFA espuma (1,23% F e III- Verniz fluoretado (2,26% F. Foram confeccionados 40 blocos de esmalte bovino, tratados de acordo com os grupos descritos, sendo um deles utilizado como controle. O F fracamente ligado (''CaF2'' ao esmalte foi determinado após a extração com 1.0 M KOH e analisado em eletrodo específico. A concentração de F encontrada no gel foi de 12.642, na espuma 12.755 e no verniz 23.183 mg F/g. Todos os produtos formaram uma quantidade significantemente maior de ''CaF2'' na superfície do esmalte, comparado ao grupo controle (p 0,05. Assim, a formação de ''CaF2'' na superfície do esmalte não foi proporcional ao conteúdo de F nos

  16. Organizational psychology: application in the professional life

    OpenAIRE

    Elizalde, Rafael; Estudiante de posgrado de Psicología, Universidad Nacional Mayor de San Marcos, Lima, Perú; Mollo F., Marybel; Estudiante de posgrado de Psicología, Universidad Nacional Mayor de San Marcos, Lima, Perú; Flores V., Jeny; Estudiante de posgrado de Psicología, Universidad Nacional Mayor de San Marcos, Lima, Perú

    2014-01-01

    This article attempts to provide insights into the importance of organizational psychology in the workplace and also how it can help resolve conflicts in the organization and supplemented with different professional fields. The authors, not psychologists, who enrolled in the final half of the Masters with a specialization in Organizational Psychology at UNMSM, expose the utility gives Organizational Psychology in their professional duties applied in the organization where they perform. El ...

  17. Building the Commercial Education Professional Competency Profile

    OpenAIRE

    Araya Muñoz, Isabel

    2012-01-01

    This paper provides a complete description of the Commercial Education Professional Competency Profile that resulted from the curricular diagnosis of the Licenciatura en Educación Comercial , at the Universidad Nacional, Costa Rica.  The methodological strategy used relies on the principles of research on education. Upon expert validation, written questionnaires were applied to first-year students, students of the licenciatura, practicing professionals and employers. The objective was to desc...

  18. Special Functions for Applied Scientists

    CERN Document Server

    Mathai, A M

    2008-01-01

    Special Functions for Applied Scientists provides the required mathematical tools for researchers active in the physical sciences. The book presents a full suit of elementary functions for scholars at the PhD level and covers a wide-array of topics and begins by introducing elementary classical special functions. From there, differential equations and some applications into statistical distribution theory are examined. The fractional calculus chapter covers fractional integrals and fractional derivatives as well as their applications to reaction-diffusion problems in physics, input-output analysis, Mittag-Leffler stochastic processes and related topics. The authors then cover q-hypergeometric functions, Ramanujan's work and Lie groups. The latter half of this volume presents applications into stochastic processes, random variables, Mittag-Leffler processes, density estimation, order statistics, and problems in astrophysics. Professor Dr. A.M. Mathai is Emeritus Professor of Mathematics and Statistics, McGill ...

  19. Professional performance in school

    Directory of Open Access Journals (Sweden)

    Rubio, J. F.

    2012-01-01

    Full Text Available Professional performance in education is now calling the attention of researcher due to its role in the professionalizing process intended to increase international education standards. In this article the term professional performance is examined from the two socio-historic traditional roles involved in training the individuals as a bio-psychic and social entity: teachers and executive. By means of scientific methods, the author gives the theoretical grounds connecting professional performance, learning and individual capacity of using them in solving problem at his labor position. The professional performance is regarded as a human value that stimulates the activity. By predicting educational alternatives, the paper portraits a model of professional performance in education, referring the necessary actions needed for achieving the goals of education. Searching and discussing such alternatives leads to reinterpret professional problems and to find out ways of improving educational standards.

  20. Gender and Topicality in Onwueme's Plays

    African Journals Online (AJOL)

    User

    2011-04-19

    Apr 19, 2011 ... often high-lighted her discussion of topical, national and global issues against the metaphorical backdrop of women ... among other things and champions of causes. This by itself is topical. For as .... youth restiveness due to unemployment on the global as well as the local levels. Her concerns touch also on ...

  1. Topic Prominence in Chinese EFL Learners' Interlanguage

    Science.gov (United States)

    Li, Shaopeng; Yang, Lianrui

    2014-01-01

    The present study aims to investigate the general characteristics of topicprominent typological interlanguage development of Chinese learners of English in terms of acquiring subject-prominent English structures from a discourse perspective. Topic structures mainly appear in Chinese discourse in the form of topic chains (Wang, 2002; 2004). The…

  2. Correlated Topic Vector for Scene Classification.

    Science.gov (United States)

    Wei, Pengxu; Qin, Fei; Wan, Fang; Zhu, Yi; Jiao, Jianbin; Ye, Qixiang

    2017-07-01

    Scene images usually involve semantic correlations, particularly when considering large-scale image data sets. This paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. Oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., Fisher vector, but do exist in scene images. It is expected that the involvement of correlations can increase the discriminative capability of the learned generative model and consequently improve the recognition accuracy. Incorporated with the Fisher kernel method, correlated topic vector inherits the advantages of Fisher vector. The contributions to the topics of visual words have been further employed by incorporating the Fisher kernel framework to indicate the differences among scenes. Combined with the deep convolutional neural network (CNN) features and Gibbs sampling solution, correlated topic vector shows great potential when processing large-scale and complex scene image data sets. Experiments on two scene image data sets demonstrate that correlated topic vector improves significantly the deep CNN features, and outperforms existing Fisher kernel-based features.

  3. Torpedo: topic periodicity discovery from text data

    Science.gov (United States)

    Wang, Jingjing; Deng, Hongbo; Han, Jiawei

    2015-05-01

    Although history may not repeat itself, many human activities are inherently periodic, recurring daily, weekly, monthly, yearly or following some other periods. Such recurring activities may not repeat the same set of keywords, but they do share similar topics. Thus it is interesting to mine topic periodicity from text data instead of just looking at the temporal behavior of a single keyword/phrase. Some previous preliminary studies in this direction prespecify a periodic temporal template for each topic. In this paper, we remove this restriction and propose a simple yet effective framework Torpedo to mine periodic/recurrent patterns from text, such as news articles, search query logs, research papers, and web blogs. We first transform text data into topic-specific time series by a time dependent topic modeling module, where each of the time series characterizes the temporal behavior of a topic. Then we use time series techniques to detect periodicity. Hence we both obtain a clear view of how topics distribute over time and enable the automatic discovery of periods that are inherent in each topic. Theoretical and experimental analyses demonstrate the advantage of Torpedo over existing work.

  4. Topic Time Series Analysis of Microblogs

    Science.gov (United States)

    2014-10-01

    of residence. Topic 158, Distance: 3.7809 Top words: 1. tracking 2. graffiti 3. station 4. plaza 5. mariachi Analysis: This topic describes Tweets by a... graffiti tracking service hired by the LA Metro Link. On the righthand side are the locations of the Metro Link stations in the area, which

  5. Corneal staining after treatment with topical tetracycline

    NARCIS (Netherlands)

    Lapid-Gortzak, Ruth; Nieuwendaal, Carla P.; Slomovic, Allan R.; Spanjaard, Lodewijk

    2006-01-01

    PURPOSE: The purpose of this paper is to report a case of corneal staining after treatment with topical tetracycline. METHODS: A patient with crystalline keratopathy caused by Streptococcus viridans after corneal transplantation was treated topically with tetracycline eye drops, based on results of

  6. Topical Antibacterials and Global Challenges on Resistance ...

    African Journals Online (AJOL)

    Nature of bacterial infections and topical antibacterials. The advantages of topical route application as compared to systemic administration include the decreased risk of systemic side effects and even toxicity, reduced the possibility to elicit bacterial resistance, and the application of high concentration of antibacterial agent ...

  7. Anesthesia: A Topic for Interdisciplinary Study.

    Science.gov (United States)

    Labianca, Dominick A.; Reeves, William J.

    1977-01-01

    Describes an interdisciplinary approach for teaching the topic of anesthesia as one aspect of a chemistry-oriented course for nonscience majors which focuses on timely topics such as the energy crisis and drugs. Historical treatment with the examination of literature is emphasized in teaching. (HM)

  8. Topical silver for treating infected wounds

    NARCIS (Netherlands)

    Vermeulen, H.; van Hattem, J. M.; Storm-Versloot, M. N.; Ubbink, D. T.

    2007-01-01

    BACKGROUND: Topical silver treatments and silver dressings are increasingly used for the local treatment of contaminated or infected wounds, however, there is a lack of clarity regarding the evidence for their effectiveness. OBJECTIVES: To evaluate the effects on wound healing of topical silver and

  9. Topical Treatment of Degenerative Knee Osteoarthritis.

    Science.gov (United States)

    Meng, Zengdong; Huang, Rongzhong

    2018-01-01

    This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy. Current treatment guidelines recommend topical nonsteroidal anti-inflammatory drugs as an alternative and even first-line therapy for OA management, especially among elderly patients. Guidelines on other topical treatments vary, from recommendations against their use, to in favor as alternative or simultaneous therapy, especially for patients with contraindications to other analgesics. Although often well-tolerated and preferred by many patients, clinical care still lags in the adoption of topical treatments. Aspects of efficacy, safety and patient quality of life data require further research. Copyright © 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  10. Exploring Topic Structure: Coherence, Diversity and Relatedness

    NARCIS (Netherlands)

    J. He (Jiyin)

    2011-01-01

    htmlabstractThe use of topical information has long been studied in the context of information retrieval. For example, grouping search results into topical categories enables more effective information presentation to users, while grouping documents in a collection can lead to efficient information

  11. Psoriasis: improving adherence to topical therapy.

    NARCIS (Netherlands)

    Feldman, S.R.; Horn, E.J.; Balkrishnan, R.; Basra, M.K.; Finlay, A.Y.; McCoy, D.; Menter, A.; Kerkhof, P.C.M. van de

    2008-01-01

    Topical therapy has an important role in psoriasis treatment. It is efficacious and has a favorable safety profile as demonstrated in clinical trials. However, poor treatment outcomes from topical therapy regimens likely result from poor adherence and ineffective use of the medication. The

  12. Dexmedetomidine premedication in cataract surgery under topical ...

    African Journals Online (AJOL)

    The ophthalmologist, blinded to the study group, measured the IOP using a Schioetz tonometer under topical analgesia in the non-operated eye. The IOP was recorded before the premedication and at the end of the surgery. Surgery was performed under topical anaesthesia using instillation of few drops of 0.5% paracaine.

  13. Fostering Topic Knowledge: Essential for Academic Writing

    Science.gov (United States)

    Proske, Antje; Kapp, Felix

    2013-01-01

    Several researchers emphasize the role of the writer's topic knowledge for writing. In academic writing topic knowledge is often constructed by studying source texts. One possibility to support that essential phase of the writing process is to provide interactive learning questions which facilitate the construction of an adequate situation…

  14. Behavior Analysis of Elderly using Topic Models

    NARCIS (Netherlands)

    Rieping, K.; Englebienne, G.; Kröse, B.

    2014-01-01

    This paper describes two new topic models for the analysis of human behavior in homes that are equipped with sensor networks. The models are based on Latent Dirichlet Allocation (LDA) topic models and can detect patterns in sensor data in an unsupervised manner. LDA-Gaussian, the first variation of

  15. Aerodynamics of wind turbines emerging topics

    CERN Document Server

    Amano, R S

    2014-01-01

    Focusing on Aerodynamics of Wind Turbines with topics ranging from Fundamental to Application of horizontal axis wind turbines, this book presents advanced topics including: Basic Theory for Wind turbine Blade Aerodynamics, Computational Methods, and Special Structural Reinforcement Technique for Wind Turbine Blades.

  16. Interactive and Hands-on Methods for Professional Development of Undergraduate Researchers

    Science.gov (United States)

    Pressley, S. N.; LeBeau, J. E.

    2016-12-01

    Professional development workshops for undergraduate research programs can range from communicating science (i.e. oral, technical writing, poster presentations), applying for fellowships and scholarships, applying to graduate school, and learning about careers, among others. Novel methods of presenting the information on the above topics can result in positive outcomes beyond the obvious of transferring knowledge. Examples of innovative methods to present professional development information include 1) An interactive session on how to write an abstract where students are given an opportunity to draft an abstract from a short technical article, followed by discussion amongst a group of peers, and comparison with the "published" abstract. 2) Using the Process Oriented Guided Inquiry Learning (POGIL) method to evaluate and critique a research poster. 3) Inviting "experts" such as a Fulbright scholar graduate student to present on applying for fellowships and scholarships. These innovative methods of delivery provide more hands-on activities that engage the students, and in some cases (abstract writing) provide practice for the student. The methods also require that students develop team work skills, communicate amongst their peers, and develop networks with their cohort. All of these are essential non-technical skills needed for success in any career. Feedback from students on these sessions are positive and most importantly, the students walk out of the session with a smile on their face saying how much fun it was. Evaluating the impact of these sessions is more challenging and under investigation currently.

  17. An Overview of Tracheal Stenosis Research Trends and Hot Topics.

    Science.gov (United States)

    Farzanegan, Roya; Feizabadi, Mansoureh; Ghorbani, Fariba; Movassaghi, Masoud; Vaziri, Esmaeil; Zangi, Mahdi; Lajevardi, Seyedamirmohammad; Shadmehr, Mohammad Behgam

    2017-09-01

    Tracheal stenosis remains a challenge in the thoracic surgery field. Recognizing the hot topics and major concepts in this area would help the health policy makers to determine their own priorities and design the effective research plans. The present study analyzed and mapped the topics and trends of tracheal stenosis studies over time as well as authors' and countries' contributions. Search results were obtained employing Bibexcel. To determine cold and hot topics, co-occurrence analysis was applied using three international databases 'Web of Science', 'PubMed' and 'Scopus'. Appropriately, different categories in the articles such as keywords, authors, and countries were explored via VOSviewer and NetDraw. Afterward, the trends of research topics were depicted in four time-intervals from 1945 to 2015 by ten co-occurrence terms. The majority of articles were limited to case series and retrospective studies. The studies had been conducted less frequently on prevention, risk factors and incidence determination but extensively on treatment and procedures. Based on the articles indexed in WOS, 45 countries and 8,260 authors have contributed to scientific progress in this field. The highest degree of cooperation occurred between the USA and England with 15 common papers. Most of the published literature in tracheal stenosis research field was about surgical and non-surgical treatments. Conducting the screening and prevention studies would diminish the burden of this disease on the health system as well as the patients and their families' well-being.

  18. Metasynthesis of Youth Suicidal Behaviours: Perspectives of Youth, Parents, and Health Care Professionals: e0127359

    National Research Council Canada - National Science Library

    Jonathan Lachal; Massimiliano Orri; Jordan Sibeoni; Marie Rose Moro; Anne Revah-Levy

    2015-01-01

    .... The aim of this review is to synthesise the views of suicidal adolescents and young adults, their parents, and their healthcare professionals on the topics of suicidal behaviour and management...

  19. Metasynthesis of youth suicidal behaviours: perspectives of youth, parents, and health care professionals

    National Research Council Canada - National Science Library

    Lachal, Jonathan; Orri, Massimiliano; Sibeoni, Jordan; Moro, Marie Rose; Revah-Levy, Anne

    2015-01-01

    .... The aim of this review is to synthesise the views of suicidal adolescents and young adults, their parents, and their healthcare professionals on the topics of suicidal behaviour and management...

  20. Danish geography teachers' perceptions of their own teaching professionalism according to climate change

    DEFF Research Database (Denmark)

    Clausen, Søren Witzel

    2015-01-01

    This paper reports from research examining eight Geography teachers’ own perceptions of their teaching professionalism, understood as Pedagogical Content Knowledge (PCK), in relation to the topic of climate change. Apparently, Geography teachers with a strong academic profile in Physical Geography...