CAKUPAN MENELAN OBAT MASSAL PENCEGAH FILARIASIS

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agus alamsyah

2016-02-01

Full Text Available Filariasis is a chronic infectious disease caused by filarial worms and transmitted by various species of mosquito. One prevention effort through prevention of mass drug administration filariasis. In the implementation of the mass medical treatment in the endemis filariasis , there are still community members who refused to swallow drug deterrent filariasis with a range of conditions and the reason. The aim of study wanted to know the scope and swallow filariasis drug-related foctors in the working area of District Health Clinics Bangko Jaya Unit, Bangko Pusako 2015. Kind of research is a quantitative analysis of cross-sectional observational design conducted in Mei 2015 work region District Health Clinics Bangko Jaya. Sample size of 106 people. Samples were distributed by way of proportional sampling, then taken using a rapid survey method. The results show that not swallow a drug prevens filaria 65,6% and swallow 34,4 %. variables that matter with the deadly drug filariasis, Namely the level of knowledge, gender, Jobs, Side effects of the drug filariasis, Socialization health worker. Puskesmas Bangko Jaya to give information to the entire community with a good strategy and the socialization ofeshek side that is not dangerous, talk with media brochures and banners.

Larvicidal Activity of Cassia occidentalis (Linn. against the Larvae of Bancroftian Filariasis Vector Mosquito Culex quinquefasciatus

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Deepak Kumar

2014-01-01

Full Text Available Background & Objectives. The plan of this work was to study the larvicidal activity of Cassia occidentalis (Linn. against the larvae of Culex quinquefasciatus. These larvae are the most significant vectors. They transmit the parasites and pathogens which cause a deadly disease like filariasis, dengue, yellow fever, malaria, Japanese encephalitis, chikungunya, and so forth, which are considered harmful towards the population in tropic and subtropical regions. Methods. The preliminary laboratory trail was undertaken to determine the efficacy of petroleum ether and N-butanol extract of dried whole plant of Cassia occidentalis (Linn. belonging to the family Caesalpiniaceae at various concentrations against the late third instar larvae of Culex quinquefasciatus by following the WHO guidelines. Results. The results suggest that 100% mortality effect of petroleum ether and N-butanol extract of Cassia occidentalis (Linn. was observed at 200 and 300 ppm (parts per million. The results obviously showed use of plants in insect control as an alternative method for minimizing the noxious effect of some pesticide compounds on the environment. Thus the extract of Cassia occidentalis (Linn. is claimed as more selective and biodegradable agent. Conclusion. This study justified that plant Cassia occidentalis (Linn. has a realistic mortality result for larvae of filarial vector. This is safe to individual and communities against mosquitoes. It is a natural weapon for mosquito control.

Larvicidal Activity of Cassia occidentalis (Linn.) against the Larvae of Bancroftian Filariasis Vector Mosquito Culex quinquefasciatus.

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Kumar, Deepak; Chawla, Rakesh; Dhamodaram, P; Balakrishnan, N

2014-01-01

Background & Objectives. The plan of this work was to study the larvicidal activity of Cassia occidentalis (Linn.) against the larvae of Culex quinquefasciatus. These larvae are the most significant vectors. They transmit the parasites and pathogens which cause a deadly disease like filariasis, dengue, yellow fever, malaria, Japanese encephalitis, chikungunya, and so forth, which are considered harmful towards the population in tropic and subtropical regions. Methods. The preliminary laboratory trail was undertaken to determine the efficacy of petroleum ether and N-butanol extract of dried whole plant of Cassia occidentalis (Linn.) belonging to the family Caesalpiniaceae at various concentrations against the late third instar larvae of Culex quinquefasciatus by following the WHO guidelines. Results. The results suggest that 100% mortality effect of petroleum ether and N-butanol extract of Cassia occidentalis (Linn.) was observed at 200 and 300 ppm (parts per million). The results obviously showed use of plants in insect control as an alternative method for minimizing the noxious effect of some pesticide compounds on the environment. Thus the extract of Cassia occidentalis (Linn.) is claimed as more selective and biodegradable agent. Conclusion. This study justified that plant Cassia occidentalis (Linn.) has a realistic mortality result for larvae of filarial vector. This is safe to individual and communities against mosquitoes. It is a natural weapon for mosquito control.

Evaluation of larvicidal activity of Acalypha alnifolia Klein ex Willd. (Euphorbiaceae) leaf extract against the malarial vector, Anopheles stephensi, dengue vector, Aedes aegypti and Bancroftian filariasis vector, Culex quinquefasciatus (Diptera: Culicidae).

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Kovendan, Kalimuthu; Murugan, Kadarkarai; Vincent, Savariar

2012-02-01

The leaf extract of Acalypha alnifolia with different solvents - hexane, chloroform, ethyl acetate, acetone and methanol - were tested for larvicidal activity against three important mosquitoes such as malarial vector, Anopheles stephensi, dengue vector, Aedes aegypti and Bancroftian filariasis vector, Culex quinquefasciatus. The medicinal plants were collected from the area around Kallar Hills near the Western Ghats, Coimbatore, India. A. alnifolia plant was washed with tap water and shade dried at room temperature. The dried leaves were powdered mechanically using commercial electrical stainless steel blender. The powder 800 g of the leaf material was extract with 2.5 litre of various each organic solvents such as hexane, chloroform, ethyl acetate, acetone, methanol for 8 h using Soxhlet apparatus, and filtered. The crude plant extracts were evaporated to dryness in a rotary vacuum evaporator. The yield of extracts was hexane (8.64 g), chloroform (10.74 g), ethyl acetate (9.14 g), acetone (10.02 g), and methanol (11.43 g). One gram of the each plant residue was dissolved separately in 100 ml of acetone (stock solution) from which different concentrations, i.e., 50, 150, 250, 350 and 450 ppm, was prepared. The hexane, chloroform, ethyl acetate, acetone was moderate considerable mortality; however, the highest larval mortality was methanolic extract observed in three mosquito vectors. The larval mortality was observed after 24 h exposure. No mortality was observed in the control. The early fourth-instar larvae of A. stephensi had values of LC(50) = 197.37, 178.75, 164.34, 149.90 and 125.73 ppm and LC(90) = 477.60, 459.21, 435.07, 416.20 and 395.50 ppm, respectively. The A. aegypti had values of LC(50) = 202.15, 182.58, 160.35, 146.07 and 128.55 ppm and LC(90) = 476.57, 460.83, 440.78, 415.38 and 381.67 ppm, respectively. The C. quinquefasciatus had values of LC(50) = 198.79, 172.48, 151.06, 140.69 and 127.98 ppm and LC(90) = 458.73, 430

Comparison of three quality of life instruments in lymphatic filariasis: DLQI, WHODAS 2.0, and LFSQQ.

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Cristina Thomas

2014-02-01

Full Text Available BACKGROUND: The Global Program to Eliminate Lymphatic Filariasis aims to interrupt transmission of lymphatic filariasis and manage morbidity in people currently living with the disease. A component of morbidity management is improving health-related quality of life (HRQoL in patients. Measurement of HRQoL in current management programs is varied because of the lack of a standard HRQoL tool for use in the lymphatic filariasis population. METHODOLOGY/PRINCIPAL FINDINGS: In this study, the psychometric properties of three health status measures were compared when used in a group of lymphatic filariasis patients and healthy controls. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0, the Dermatology Life Quality Index (DLQI, and the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ were administered to 36 stage II and stage III lymphatic filariasis subjects and 36 age and sex matched controls in Kerala, India. All three tools yielded missing value rates lower than 10%, suggesting high feasibility. Highest internal consistency was seen in the LFSQQ (α = 0.97. Discriminant validity analysis demonstrated that HRQoL was significantly lower in the LF group than in controls for the WHODAS 2.0, DLQI, and LFSQQ, but total HRQoL scores did not differ between stage II and stage III lymphedema subjects. The LFSQQ total score correlated most strongly with the WHODAS 2.0 (r = 0.91, p<0.001 and DLQI (r = 0.81, p<0.001. CONCLUSIONS/SIGNIFICANCE: The WHODAS 2.0, DLQI, and LFSQQ demonstrate acceptable feasibility, internal consistency, discriminate validity, and construct validity. Based on our psychometric analyses, the LFSQQ performs the best and is recommended for use in the lymphatic filariasis population.

Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: A modelling study

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M.A. Irvine (Michael A.); W.A. Stolk (Wilma); Smith, M.E. (Morgan E); S.V. Subramanian; B.K. Singh (Brajendra K.); G.J. Weil (Gary); E. Michael (Edwin); T.D. Hollingsworth (T. Déirdre)

2017-01-01

textabstractBackground: Lymphatic filariasis is targeted for elimination as a public health problem by 2020. The principal approach used by current programmes is annual mass drug administration with two pairs of drugs with a good safety profile. However, one dose of a triple-drug regimen

Filariasis in the new millennium

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R. H.H. Nelwan

2001-09-01

Full Text Available The lndonesian national filariasis eradication program in its pursuit in obtaining microfilarial rates below 1% in filariasis endemic locations was on its right track until the monetary crisis started 3 years ago. This crisis which is not over yet at present is complicated by unstable public safety causing population shifts where people from filaria endemic locations seek refuge in non-endemic areas. This updated review will hopefully serve as a timely reminder to our physicians and health workers especially on the mode of filarial transmission as well as on its clinical presentations and presently accepted ways of manaqement. This paper also will serve as an introduction into the present breakthroughs in this new millenium as noted in the field of diagnostics and simplified mass treatment schedules making it possible for the elimination of lymphatic filariasis as a public health problem. A global alliance under the guidance of the World Health Organization with support of the multinational pharmaceutical companies for providing free expensivemedication as needed. The WHO also cooperates closely with the Tropical Diseases Research task forces of Filariasis Intervention Research and of Product Development, that in the end will provide the means to eradicate this disease for once and forever from the face of the earth. (Med J Indones 2001; 10: 191-6Keywords: Lymphatic filariasis, filarial lifecycle, global alliance, historical milestones

Kondisi Filariasis Pasca Pengobatan Massal di Kelurahan Pabean Kecamatan Pekalongan Utara Kota Pekalongan

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Bondan Fajar Wahyudi

2016-07-01

Full Text Available Pekalongan city is endemic for filariasis. Filariasis Mass Drug Administration (MDA implemented to decrease filariasis endemicity in Pekalongan and was started in 2011, but especially the Pabean Village has started implementing in 2009. The study aimed to determine the post-filariasis MDA by measuring filariasis endemicity parameters include the distribution of patients, microfilariae rate, microfilariae density, microfilariae species and adherence of the people. A descriptive study with cross sectional design was conducted in Pabean village, Pekalongan city. Finger Blood Filariasis slide and medication status of those who had Filariasis MDA in 2011-2013 were examined. Finger Blood Filariasis slide of 519 respondents examined found 7 (Mf rate 1.35% microfilariae positive, decreased from 2007, accounted for 3.4% and spread almost evenly throughout the village. Microfilariae density accounted for 229.02 per ml of blood and only one species of filarial worms found as Wuchereria brancrofti. Respondents who received the drug in 2011, 2012, and 2013 increased (80.02%, 90.75%, 92.68% respectively, but respondents who were taking medication decreased (63.01% 60.89%, and 55, 88% respectively. From this findings, filariasis endemicity parameters showed that filariasis MDA for 5 years have not been able to eliminate filariasis endemicity despite of the drop parameter. Key words : filariasis, microfilariae, mass drug administration

HUBUNGAN FAKTOR LINGKUNGAN FISIK DENGAN KEJADIAN FILARIASIS DI INDONESIA

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Santoso Santoso

2016-07-01

Full Text Available ABSTRACTFilariasis is still a public health problem in Indonesia. Over 10 years (2000-2009 the spread of filariasis inIndonesia are increasing in all over Indonesia. The numbers of clinical cases found were 6,233 cases in 2000 and increased in 2009 to 11,914 cases scattered throughout 33 provinces. Some factors that led to thehigher number of filariasis cases in Indonesia were poor sanitation and limited access to health carefacilities. The data for this analysis was derived from Basic Health Research 2007. The results showedthere were statistically significant relationship between the characteristics of respondents, the type andcondition of the waste water reservoirs, sewerage conditions, the presence of medium and large livestock, classification of areas and the incidence of filariasis.Keywords: Filariasis, characteristics, waste water disposal ABSTRAKFilariasis masih menjadi masalah kesehatan di Indonesia. Selama 10 tahun (2000-2009 penyebaranfilariasis di Indonesia terus meningkat yang meliputi hampir seluruh wilayah Indonesia. Jumlah kasusklinis yang ditemukan tahun 2000 sebanyak 6.233 kasus dan meningkat pada tahun 2009 menjadi 11.914kasus yang tersebar di 33 provinsi. Beberapa faktor yang menyebabkan masih tingginya kasus filariasis diIndonesia diantaranya kondisi sanitasi lingkungan yang kurang baik dan sulitnya akses ke sarana pelayanankesehatan. Data yang digunakan dalam analisis ini adalah data hasil Riskesdas tahun 2007. Hasil analisismenunjukkan adanya hubungan yang bermakna secara statistik antara karekateristik responden, jenis dankondisi penampungan air limbah, kondisi saluran air limbah, keberadaan ternak sedang dan besar, dan klasifikasi daerah dengan kejadian filariasis.Kata kunci: Filariasis, karakteristik, pembuangan air limbah

FAKTOR-FAKTOR YANG MEMPENGARUHI KEJADIAN FILARIASIS DI INDONESIA (DATA RISKESDAS 2007

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Mardiana Mardiana

2012-11-01

Full Text Available Filariasis or elephantiasis diseases which caused by filaria worm and contagious through mosquito bite, still the major community health problem in Indonesia. There are several type of filaria worm in Indonesia, i.e. Wuchereria bancrofti, Brugia malayi and Brugia timori. The vectors of filariasis are Culex quinquefasciatus in the urban area, Anopheles spp, Aedes spp and Mansonia spp in the rural area. The infection risk in some area of filariasis related to the situation of local area. Various factor of environmental area which area physical, biological and also cultural social to be influence to development of transmitted filariasis by mosquito. The analysis of data Riskesdas 2007 has been done to perform of factor influence filariasis case in Indonesia. Same parameters was analyzed to case of filariasis in last 12 months; gender, ages, educations, work, mosquito net usage, sources of water, effluent dismissal, residences, water dismissal channel, existence of livestock in house. From analysis inferential, show there is no relation between genders, age, education, work, and mosquito net usage, sources of water, water dismissal channel, and existence of livestock in house to case filariasis. Statistically indicates that there is significantly difference between residences in rural and in urban to case of filariasis in last 12 months. Responder who live in rural areas (0,05% have 2,4 times risk higher than responder who live in urban (0,03%. The same as condition of water dismissal channel shows to existence of significantly differences. Responder who have water dismissal channel without cover have high risk infections of filariasis in the last 12 months were 0,05%, while the responder have water dismissal channel with cover have high risk in last 12 months were 0,03%. Keywords: Filariasis, endemic area, factors

COMPARATIVE STUDIES ON MAN-BITING POPULATION OF FILARIAL VECTOR Cx. quinquefasciatus (Diptera: Culicidae BETWEEN TRIBAL AND NON-TRIBAL AREAS OF BANKURA DISTRICT, WEST BENGAL INDIA

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G. Chandra

2012-10-01

Full Text Available West Bengal, India is endemic for filariasis and the number of patients infected with bancroftian filariasis is increasing. There are no observation on the potential vector of filariasis from the tribal areas that make up considerable part in this state. This study investigate population of Cx. quinquefasciatus in tribal and non-tribal areas of Bankura district. Species composition of mosquitoes, per man-hour density, hourly densities of night biting Cx. quinquefasciatus, number of Cx. quinquefasciatus biting per man per day and per man per night. Preferential biting site and peak period of filarial transmission were recorded from both the study areas. Infection rate, infectivity rate of man-landing vector population and annual transmission potential were observed to be 0.31%, 0.00% and 0.00 in tribal areas and 0.73%, 0.23% and 359.71 in non-tribal areas respectively.

FAKTOR RISIKO KEJADIAN FILARIASIS DI KELURAHAN JATI SAMPURNA

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Dewi Susanna

2010-06-01

Full Text Available Risk Factors of Filariasis in Jati Sampurna Village. The subdistrict Jati Sampurna is the most endemic area of filariasis in Bekasi City. This study was undertaken to get a picture of the situation and find the dominant risk factors associated with the occurrence of filariasis in the subdistrict. The research design encompasses case-study control with a total of 93 respondents. The variables studied were the physical environment in a house with six risk factors, characteristics of individuals with three risk factors, the physical environment outside the home, behavior, and the source transmitters, each of which with one risk factor. The risk factors associated with the incidence of the disease are the ceiling construction of the house, objects hanging in the house, the presence of wire screens, gender and the habit of going out at night. These four risk factors, in addition to the use of mosquito nets, is considered as the most dominant risk factors in the occurrence of filariasis in Kelurahan Jati Sampurna.

Analisis Spasial Kejadian Filariasi di Kabupaten Demak Jawa Tengah

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Nurjazuli Nurjazuli

2018-04-01

Full Text Available Latar Belakang: Filariasis merupakan salah satu penyakit tular vektor yang kurang mendapatkan perhatian, termasuk kelompok Neglected Tropical Diseases (NTDs. Kabupaten Demak merupakan salah satu wilayah di Propinsi Jawa Tengah  yang merupakan daerah endemis filarisis (mf rate>1%. Kejadian filarisis di daerah ini diduga berkaitan dengan kondisi lingkungan fisik dan biologis (nyamuk yang mempunyai peran penting dalam penyebaran penyakit filarisis. Penelitian ini bertujuan untuk menemukan adanya penderita baru,  mengidentifikasi kondisi lingkungan fisik dan biologi yang berkaitan dengan sebaran filarisis di Kabupaten Demak. Matede: Penelitian ini merupakan penelitian observasional dengan rancangan cross-sectional. Sebanyak 30 kasus filariasis dijadikan indek kasus yang selanjutnya dipilih secara purposif sebanyak 140 yang tinggal di sekitar 30 kasus tersebut untuk dilakukan pengamblan darah jari. Observasi lingkungan dilakukan untuk mengidentifikasi kondisi lingkungan (breeding places dan resting places dari yang diduga sebagai nyamuk vektor filariasis. Penangkapan nyamuk dilakukan di sekitar rumah penderita filariasis. Pengukuran koordinat kasus filariais dilakukan dengan pesawat Geographic Positioning System (GPS. Pemeriksaan darah jadi jari dilakukan di Laboratorium Kesehatan Daerah (LABKESDA Propinsi Jawa Tengah. Sedang bedah nyamuk dilakukan di Balai Penelitian Vektor Penyakit Banjarnegara. Analisis data dlakukan secara deskriptif, analisis spasial dilakukan dengan software ArcGis 9.3. Hasil: Penelitian ini tidak menemukan penderita baru filarisis (mf rate=0%. Sebanyak 129 ekor nyamuk telah dilakukan pembedahan dengan hasil semuanya negatip cacing filaria. Hasil identifikasi nyamuk menemukan spesies nyamuk Culex quinquefasciatus merupakan nyamuk yang dominan (72,86% di lokasi penelitian.Terdapat breeding places (40% berupa genangan air terbuka (SPAL dan resting places (83,3% berupa semak-semak di sekitar rumah penderita. Analisis spasial

PENULARAN FILARIASIS DI PEMUKIMAN TRANSMIGRASI KUMPEH, JAMBI DITINJAU DARI ASPEK SOSIO ANTROPOLOGI

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M. Sudomo

2012-09-01

Full Text Available Study on the socio-cultural aspects in relation to filariasis transmission dynamics was carried out in the transmigration area of Kumpeh, Iambi. In this study a number of 266 respondents originated from Java were interviewed. Beside interview by using questionnaires, focus group discussions and observation were also implemented. From this study it was known that the word "filariasis" seemed to be unpopular among the transmigrants. They used to called the disease untut or penyakit kaki gajah. A great number of the respondents stated that the disease is transmitted through mosquito bites, but they did not know the mode of the transmission. A small number of the respondents were of the opinion that the disease was hereditary and this knowledge was adopted from the local inhabitants. The attitude of the respondents towards filariasis control measures was positive, and it was shown among others, by their willingness to be bled for filariasis examination. Their behaviour in its connection with filariasis transmission was not supportive towards filariasis control e.g. they used to stay in the ladang, and chat outdoor during the night without protection against mosquito bites. From this study it was also known that they exposed themselves to the mosquito bites mainly in the ladang when they take guard of their crops from pests damages. Their low education affected their perception towards filariasis and will hamper health education on filariasis control.

BILATERAL CYSTIC SWELLING OVER SCAPULA-An Unusual Presentation of Filariasis

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Deepak Kumar

2018-05-01

Full Text Available Lymphatic filariasis is a parasitic infection commonly known as elephantiasis. Filariasis presents as hydrocele, genital/scrotal swelling, adenolymphangitis (ADL, swelling of limbs, and genitalia. The causative agent resides in lymphatic channels and causes its obstructions leading to lymphedema. In India, males commonly present with hydrocele and females with lymphedema. Filariasis presenting as bilateral cystic swelling over the scapula is very rare even in endemic areas like India. Wuchereria bancrofti is the common causative agent of filarial infections in India. Here, we present a rare case of filariasis presenting as bilateral cystic swelling over the scapula. The imaging findings are discussed in the case report, which leads us to the diagnosis with further confirmation on microscopy by the presence of microfilariae within the cyst.No such case has been reported in the literature.

Cakupan Pemberian Obat Pencegahan Massal Filariasis di Kabupaten Sumba Barat Daya Tahun 2012-2013

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Zahrotul Habibah

2016-03-01

Full Text Available Filariasis merupakan masalah kesehatan masyarakat terutama di Indonesia Timur antara lain di Kabupaten Sumba Barat Daya (SBD. Untuk mengeliminasi filariasis, WHO membuat program PemberianObat Pencegahan Masal (POPM dengan dietilkarbamazin sitrat dan albendazol setiap tahun selama 5tahun berturut-turut. Untuk mengetahui keberhasilan POPM, perlu dilakukan evaluasi cakupan POPM setiaptahun. Tujuan penelitian ini adalah mengetahui cakupan POPM di SBD pada tahun 2012-2013. Penelitanini menggunakan data POPM Dinas Kesehatan SBD pada tahun 2012 dan 2013. Cakupan POPM filariasisdihitung berdasarkan jumlah penduduk minum obat dibagi penduduk total dan jumlah penduduk sasaran.Target cakupan pengobatan penduduk sasaran adalah >85% dan dari penduduk total adalah  > 65%. Hasilpenelitian menunjukkan cakupan POPM filariasis berdasarkan penduduk total pada tahun 2012 adalah 1,96%dan tahun 2013 sebesar 1,13%. Cakupan POPM filariasis berdasarkan penduduk sasaran pada tahun 2012adalah 2,51% dan tahun 2013 adalah 1,35%. Disimpulkan bahwa cakupan POPM filariasis berdasarkanpenduduk sasaran dan penduduk total di SBD sangat rendah dan cakupan tahun 2013 lebih rendahdibandingkan tahun 2012. Kata kunci: W. bancrofti, B.malayi, B.timori, pemberian obat masal pencegahan, Sumba Barat Daya   Coverage of Mass Drugs Administration (MDA for Filariasis inSouth West Sumba on 2012-2013 AbstractFilariasis is a disease caused by Wuchereria bancrofti, Brugia malayi and Brugia timori. It is transmitted by mosquitos. It cause defect in patient’s physical condition, decrease social life, and increase health spending.WHO concepts a program to eliminate filariasis by Massal Drugs Administration (MDA of filariasis. It hasto be evaluated each year in five years by counting the coverage of MDA of filariasis in total population andtargeted population. This research used secondary data from Dinas Kesehatan in SBD to know the coverageof MDA of filariasis in SBD on 2012-2013. The coverage

Avaliação do teste de imunofluorescência indireta para diagnóstico da filariose bancroftiana usando a microfilária de W. bancrofti como antígeno, em Recife-PE, Brasil Evaluation of indirect immunofluorescence test for bancroftian filariasis using Wuchereria bancroft microfilariae as the antigen in Recife, Brazil

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Gerusa Dreyer

1991-10-01

Full Text Available Analisou-se o teste de imunofluorescência indireta com microfilárias de W. bancrofti tratadas pela papaína, como antígeno, amplamente utilizado em Recife para o imunodiagnóstico da filariose linfática. Foram testados soros de 50 pacientes portadores das diversas formas clínicas da doença, incluindo microfilaremia assintomática, eosinofilia pulmonar tropical, elefantíase de membros inferiores, linfagite aguda e quilúria. Para o grupo controle, foram selecionados 50 indivíduos vivendo pelo menos há 5 anos em área endêmica, sem nenhuma evidencia clínica e/ou laboratorial da doença, constituindo os chamados endêmicos normais. A sensibilidade e especificidade do teste, segundo diferentes pontos de corte, mostraram a impossibilidade de diferenciação entre o grupo controle e o grupo sabidamente infectado. Também não foi possível estabelecer correlação entre os títulos encontrados e as diferentes formas clínicas. Foi considerada a existência de reações cruzadas relacionadas a helmintíases intestinais, porém nenhuma relação direta foi encontrada.The authors analysed the indirect immunofluorescence assay, for the diagnosis of bancroftian filariasis using papain treated W. bancrofti microfilariae as antigen, widely used in Recife - Brazil. Sera from 50 patients with several clinical forms of the disease including asymptomatic carriers, tropical pulmonary eosinophilia, elephantiasis, filarial fever and chyluria were analysed. For the control group, 50 individuals were selected, living at least 5 years in endemic area, with neither previous DEC treatment nor clinical-laboratory evidences of the disease, called normals endemic. The sensitivity and specificity were analised taking into account different cut off values. It was not possible to differentiate infected individuals from the control group. It was not even possible to establish any correlation with IMF titers among different clinical presentation of the disease

Surgical manifestations of filariasis

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Subrahmanyam M

1978-01-01

Full Text Available Surgical manifestations of filariasis as seen in 150 cases over a period of three years in the department of Surgery, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha are reviewed. The genital manifestations are more common than the elephantiasis in this endemic zone.

Faktor-Faktor Lingkungan dan Perilaku Yang Berhubungan dengan Kejadian Filariasis di Kabupaten Bangka Barat

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Nasrin Nasrin

2015-11-01

Full Text Available ABSTRACT Background : West Bangka district is one of the endemic areas of filariasis in Indonesia. In  2007, It was found about 36 chronic cases of filariasis. The high incidence of  filariasis cases in West Bangka Regency  was caused by many factors in  the environment,  such as swamp and ponds or  hole in tin mining area which was flooded when raining or in rainy seasons.  The aim of this research was to find out  factors related to the filariasis incidence in West Bangk Regency. Method : It was an observational research using case control design. The subjects of this research was devided in  two groups: cases and controls with 37 subjects of each group. The variables assessed in this research including  physical factors (swamp / pool, Biological (water plants, fish/animal predators for  the environmental factors and education, job and income as socioecomic factor Behavioural  factors were  consisted of  hanging out habit  at night, wearing clothes to protect mosquitoes bite that might influenced the filariasis incidence in West Bangk Regency. The data were analyzed using multiple logistic regression  at 5%  level of significance. Result : The result of this research showed that there were seven variabels asrisk factors of  filariasis incidence in West Bangka Regency,including: respondent’s job  with OR = 3,695, respondent’s income level  with OR = 4,2,  the existence of swamp OR = 3,151, habit of using mosquito repellent with OR = 5,063, respondent’s knowledge about filariasis OR = 4,259, respondent’s knowledge about filariasis infection with OR =3,571 and respondent’s knowledge about filariasis prevention OR= 3,73. Conclusion : Environmental and behavioural factor were related to filariasis incidence in West Bangka District. It was recommended to improve those factors by implementing health promotion intensively. Keyword   : Filariasis, enviromental and behavioral factors, West Barat District.

Pengetahuan, Sikap Dan Perilaku Masyarakat Pasca Pengobatan Dan Pengaruhnya Terhadap Endemisitas Filariasis Di Kabupaten Tanjung Jabung Timur

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Santoso Santoso

2017-02-01

Full Text Available AbstractLymphatic filariasis (elephantiasis is a health problem in Indonesia, including in East Tanjung Jabung. Lymphatic filariasis elimination program in Indonesia was done by breaking the chain of transmission of filariasis with mass drug administration (MDA. The effectiveness of MDA program depends on knowledge, attitudes and practice (KAP of the community. This study aims to determine the KAP towards lymphatic filariasis and evaluate MDA program. The study was conducted in two phases, namely interviews and finger blood survey (FBS. The number of respondents who interviewed were 117 and the number of people who had blood tests as many as 1,209. Interviews result showed that most respondents knew about lymphatic filariasis. The attitude of the majority of respondents showed a positive attitude. Interviews showed that the behavior of people taking medication was high (88%. Based on the results of the proportion of positive FBS, microfilariae were dominants found in people who do not take medication. Although the knowledge of community is high, the East Tanjung Jabung still declared as filariasis-endemic areas because it found the village with a number of microfilaria (Mf rate of more than 1%.Keywords: Lymphatic filariasis, KAP, East Tanjung Jabung, endemisAbstrakFilariasis (penyakit kaki gajah masih merupakan masalah kesehatan di Indonesia termasuk di Kabupaten Tanjung Jabung Timur. Program eliminasi filariasis di Indonesia dilakukan dengan pemutusan mata rantai penularan melalui pemberian obat massal pencegahan (POMP filariasis. Keberhasilan program POMP filariasis dipengaruhi oleh pengetahuan, sikap dan perilaku (PSP masyarakat tentang filariasis. Penelitian ini bertujuan untuk mengetahui PSP masyarakat terhadap filariasis dan evaluasi kegiatan POMP filariasis. Penelitian dilakukan dalam 2 tahap, yaitu wawancara dan survei darah jari (SDJ. Jumlah responden yang diwawancarai sebanyak 117 orang dan jumlah penduduk yang diperiksa darahnya

Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects.

Science.gov (United States)

Chandrasena, Nilmini; Premaratna, Ranjan; Gunaratna, Indeewarie E; de Silva, Nilanthi R

2018-05-01

Sri Lanka was acknowledged to have eliminated lymphatic filariasis (LF) as a public health problem in 2016, largely due to its success in Mass Drug Administration (MDA) to interrupt disease transmission. Analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT) of the national Morbidity Management and Disability Prevention (MMDP) program, the other pillar of the LF control program, was carried out with the objective of evaluating it and providing recommendations to optimize the use of available resources. A situation analysis of the MMDP activities provided by the state health sector was carried out using published records, in-depth interviews with key informants of the Anti Filariasis Campaign, site-visits to filariasis clinics with informal discussions with clinic workforce and personal communications to identify strengths and weaknesses; and opportunities to overcome weaknesses and perceived threats to the program were explored. The principal strength of the MMDP program was the filariasis clinics operational in most endemic districts of Sri Lanka, providing free health care and health education to clinic attendees. The weaknesses identified were the low accessibility of clinics, incomplete coverage of the endemic region and lack of facilities for rehabilitation. The perceived threats were diversion of staff and resources for control of other vector-borne infections, under-utilization of clinics and non-compliance with recommended treatment. Enhanced high level commitment for MMDP, wider publicity and referral systems, integration of MMDP with other disease management services and collaboration with welfare organizations and research groups were identified as opportunities to overcome weaknesses and challenges. The recommended basic package of MMDP was functional in most of the LF-endemic region. The highlighted weaknesses and challenges, unless addressed, may threaten program sustainability. The identified opportunities for improvement of the

Lymphatic filariasis among the Yakurr people of Cross River State, Nigeria

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Iboh Cletus I

2012-09-01

Full Text Available Abstract Background In order to initiate a disease elimination programme for lymphatic filariasis based on mass drug administration, a proper understanding of the geographical distribution and degree of risk is essential. Methods An investigation of lymphatic filariasis due to Wuchereria bancrofti was carried out among 785 people in four communities of Yakurr Local Government Area of Cross River State, Nigeria between March and August, 2009. Finger prick blood smear samples collected from the subjects were examined for W. bancrofti using standard parasitological protocol. The subjects were also screened for clinical manifestations of lymphatic filariasis. Results Of the 785 persons examined, 48 (6.1% were positive for microfilariae in their thick blood smear. There was a significant difference in the prevalence of lymphatic filariasis among the various age groups (P  0.05. The overall mean microfilarial density of the infected individuals was 5.6mf/50 μl. There was a significant variation (P  Conclusions The National Lymphatic Filariasis Elimination Programme should intervene by expanding the distribution of albendazole and ivermectin to all endemic areas including Yakurr Local Government Area of Cross River State, Nigeria.

Bancroftian filariasis in two urban areas of Recife, Brasil: the role of individual risk factors Filariose bancroftiana em duas áreas urbanas do Recife, Brasil: o papel dos fatores de risco individuais

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M. de Fátima Militão de Albuquerque

1995-06-01

Full Text Available Bancroftian filariasis is spreading in towns of endemic areas as in Recife, northeastern Brazil, where it is a major public health problem. This paper deals with the prevalence of microfilaraemia and filarial disease in two urban areas of Recife, studying their association with individual characteristics and variables related to the exposure to the vectors. The parasitologic survey was performed through a "door-to-door" census and microfilaraemia was examined by the thick-drop technique using 45µl of peripheral blood collected between 20:00 and 24:00 o' clock. 2,863 individuals aged between 5 and 65 years were interviewed and submitted to clinical examination. Males aged between 15 and 44 years old presented the greatest risk of being microfilaraemic. Microfilaraemia was also significantly associated with no use of bednet to sleep. The risk of being microfilaraemic was greater among those who had lived in the studied areas for more than 5 years. The overall disease prevalence was 6.3%. Males presented the greatest risk of developing acute disease. The risk of developing chronic manifestations was also greater among males and increased with age. We found no association between time of residence, bednet use, microfilaraemia and acute and chronic disease. We may conclude that in endemic areas there are subgroups of individuals who has a higher risk of being microfilariae carriers due to different behaviours in relation to vector contact.A Filariose bancroftiana está se disseminando em áreas urbanas de regiões endêmicas como no Recife, nordeste do Brasil, onde se constitui em um problema de saúde pública. Este artigo descreve a prevalência de microfilaremia e doença filarial em duas áreas urbanas do Recife, estudando sua associação com características individuais e variáveis relacionadas ao contacto com vetores. O inquérito parasitológico foi realizado através de um censo "porta-a-porta" e a pesquisa de microfilárias foi efetuada

Non-endemic cases of lymphatic filariasis.

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Jones, Robert T

2014-11-01

Several cases of lymphatic filariasis (LF) have been reported in non-endemic countries due to travellers, military personnel and expatriates spending time in and returning from endemic areas, as well as immigrants coming from these regions. These cases are reviewed to assess the scale and context of non-endemic presentations and to consider the biological factors underlying their relative paucity. Cases reported in the English, French, Spanish and Portuguese literature during the last 30 years were examined through a search of the PubMed, ProMED-mail and TropNet resources. The literature research revealed 11 cases of lymphatic filariasis being reported in non-endemic areas. The extent of further infections in recent migrants to non-endemic countries was also revealed through the published literature. The life-cycle requirements of Wuchereria and Brugia species limit the extent of transmission of LF outside of tropical regions. However, until elimination, programmes are successful in managing the disease, there remains a possibility of low rates of infection being reported in non-endemic areas, and increased international travel can only contribute to this phenomenon. Physicians need to be aware of the signs and symptoms of lymphatic filariasis, and infection should be considered in the differential diagnosis of people with a relevant travel history. © 2014 John Wiley & Sons Ltd.

Epidemiological assessment of neglected diseases in children: lymphatic filariasis and soil-transmitted helminthiasis.

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Aguiar-Santos, Ana M; Medeiros, Zulma; Bonfim, Cristine; Rocha, Abraham C; Brandão, Eduardo; Miranda, Tereza; Oliveira, Paula; Sarinho, Emanuel S C

2013-01-01

To report the prevalence of lymphatic filariasis and intestinal parasitic infections in school-aged children living in a filariasis endemic area and discuss about the therapeutic regimen adopted in Brazil for the large-scale treatment of filariasis. A cross-sectional study including 508 students aged 5-18 years old, enrolled in public schools within the city of Olinda, Pernambuco. The presence of intestinal parasites was analyzed using the Hoffman, Pons and Janer method on 3 stool samples. The diagnosis of filarial infection was performed using the rapid immunochromatographic technique (ICT) for the antigen, and the polycarbonate membrane filtration for the presence of microfilariae. Descriptive statistics of the data was performed using EpiInfo version 7. The prevalence of filariasis was 13.8% by ICT and 1.2% by microfilaraemia, while intestinal parasites were detected in 64.2% of cases. Concurrent diagnosis of filariasis and intestinal parasites was 9.4%, while 31.5% of students were parasite-free. Among individuals with intestinal parasites, 55% had one parasite and 45% had more than one parasite. Geohelminths occurred in 72.5% of the parasited individuals. In the group with filarial infection the prevalence of soil-transmitted helminthiasis was 54.5%. The simultaneous diagnosis of filariasis and intestinal parasites as well as the high frequency of geohelminths justify the need to reevaluate the treatment strategy used in the Brazilian filariasis large-scale treatment program. Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

Evaluating Vaccine Candidates for Filariasis

Science.gov (United States)

2013-04-16

causative agents of lymphatic filariasis, W. bancrofti, B. malayi, or B. timori, and that the worldwide prevalence of genital disease or lymphedema...St. Louis, Missouri: Saundeers Elsevier 71. Johnson MH, Orihel TC, Beaver PC. 1974. Dipetalonema viteae in the experimentally infected jird

Lymphatic filariasis control in Tanzania

DEFF Research Database (Denmark)

Simonsen, Paul Erik; Derua, Yahya A.; Kisinza, William N.

2013-01-01

Control of lymphatic filariasis (LF) in most countries of sub-Saharan Africa is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. We present findings from a detailed study on the effect of six rounds of MDA...

Lymphatic Filariasis control in Tanzania

DEFF Research Database (Denmark)

Simonsen, Paul Erik; Pedersen, Erling Møller; Rwegoshora, Rwehumbiza T.

2010-01-01

In most countries of sub-Saharan Africa the control of lymphatic filariasis (LF) is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. Here we present the first detailed study on the effect of 3 repeated MDAs...

Studies on humoral and cellular immune responses in filariasis: Use of nuclear techniques

International Nuclear Information System (INIS)

Subrahmanyam, D.; Chaudhuri, S.

1975-01-01

Immunologic studies in filariasis have been concentrated on areas such as (a) isolation of a specific antigen(s) for early diagnosis of the disease, (b) host-parasite relation in the infection and (c) factors involved in inducing resistance to the infection. The paper discusses information obtained on these aspects with experimental filariasis and its possible implications for the human disease. Areas of research where nuclear techniques could contribute further to a greater understanding of the immunology of filariasis are also indicated. (author)

Faktor-Faktor yang Berhubungan dengan Kejadian Filariasis di Kabupaten Padang Pariaman Tahun 2010-2013

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Dhia Afra

2016-01-01

Full Text Available AbstrakFilariasis adalah penyakit menular menahun yang disebabkan oleh cacing filaria dan ditularkan oleh nyamuk Mansonia, Anopheles, Culex, Armigeres. Banyak faktor risiko yang mampu memicu timbulnya kejadian filariasis. Beberapa diantaranya adalah jenis kelamin, usia, pekerjaan, faktor lingkungan, perilaku. Kabupaten Padang Pariaman bukan salah satu 5 kabupaten daerah endemis filariasis namun merupakan kabupaten yang banyak ditemukan kasus baru filariasis di Sumatera Barat. Penelitian ini menggunakan metode studi case control yang merupakan penelitian epidemiologis analitik observasional yang bersifat retrospektif. Jumlah sampel sebanyak 63 responden, terdiri dari 21 kasus dan 42 kontrol. Analisis data yang digunakan yaitu analisis univariat dan bivariat dengan menggunakan uji chi-square. Hasil uji statistik chi-square menunjukkan bahwa terdapat hubungan antara umur dengan kejadian filariasis dengan nilai p= 0,013,tetapi tidak terdapat hubungan yang bermakna antara jenis kelamin, pekerjaan(nilai p= 0,071, OR=3,800, 95% CI=0,938-15,398, tempat perindukan, pengetahuan (nilai p= 1,000, OR=1,135, 95% CI=0,336-3,835, sikap dan tindakan. Mengingat umur sangat erat hubungannya dengan pekerjaan, maka perlu ada penyuluhan dari petugas kesehatan bagaimana melindungi diri saat bekerja seperti menggunakan baju berlengan panjang dan celana panjang, serta menggunakan obat anti nyamuk.Kata kunci: filariasis, umur, pekerjaan, tempat perindukan, perilaku AbstractFilariasis is a chronic communicable disease caused by filarial worms and transmitted by mosquitoes Mansonia, Anopheles, Culex, Armigeres. Many risk factors are able to prevalence of filariasis. Some of them are gender, age, occupation, environmental factors and behavioral. Pariaman District is not one of the 5 districts of filariasis endemic areas but a lot of new case have been identify in West Sumatra. This was a case control study which is an analytic observational epidemiological studies. The

Epidemiological Assessment of Neglected Diseases in Children: Lymphatic Filariasis and Soil-Transmitted Helminthiasis

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Ana M. Aguiar-Santos

2013-05-01

Conclusions: The simultaneous diagnosis of filariasis and intestinal parasites as well as the high frequency of geohelminths justify the need to reevaluate the treatment strate- gy used in the Brazilian filariasis large-scale treatment program.

Karakteristik Habitat Perkembangbiakan Vektor Filariasis di Kecamatan Kodi Balaghar Kabupaten Sumba Barat Daya

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Mefi Mariana Tallan

2016-12-01

Full Text Available Abstract. Subdistrict scores balaghar is on filariasis endemic areas in the shouthwest district Sumba. Filariasis (elephantiasis is a chronic infectious disease caused by the filarial worm that attacks the lymph channels and lymph (lymphatic system that can cause acuteor chronic clinical symptoms and is transmitted by mosquitoes Mansonia, Anopheles, Culex, Amigeres. The purpose researchis to describe the characteristics of the environment and behavior to the incidence on filariasis in District Kodi Balaghar South western Sumba. This research is descriptive study with cross sectional approach that describes the spread of filariasis. Kodi was conducted in Southwest Sumba Regency Balaghar for eight months from April to November 2014. Foundas apotential habitat forlas mosquito breeding habitats where dominant is a puddle of water, springs, drains and small stream swith temperatures ranging from21-350C, from 0,22 to 795luxillumination, range pH between7,2 to 7,7, 0-0.1‰ salinity with elevation ranging from 25-117m/asl. Where is thespecies found in the breeding habitat on is An.vagus, An.barbirostris, An.annularis, Cx.vishnui, Cx.bitaeniorhynchus, Cx.quinquefasciatus, Ar. Kuchingensis.Keywords:Filariasis, Environment, Breeding habitatsAbstrak. Kecamatan Kodi Balaghar merupakan salah satu daerah endemis filariasis di Kabupaten Sumba Barat Daya. Filariasis (penyakit kaki gajah adalah penyakit menular menahun yang disebabkan oleh cacing filaria Wuchereria brancofti, Brugia malayidan B. timori yang menyerang saluran dan kelenjar getah bening (sistem limfatik yang dapat menyebabkan gejala klinis akut atau kronis dan ditularkan oleh nyamuk Mansonia, Anopheles, Culex, Amigeres. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik lingkungan fisik dan biologi di Kecamatan Kodi Balaghar Kabupaten Sumba Barat Daya. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional yaitu menggambarkan karakteristik lingkungan fisik

Lymphatic Filariasis: Transmission, Treatment and Elimination

NARCIS (Netherlands)

W.A. Stolk (Wilma)

2005-01-01

textabstractLymphatic filariasis (LF) is a mosquito-borne, tropical disease caused by filarial worms. Infection can lead to disabling chronic disease, characterized by swelling of extremities or external genitalia (lymphoedema, elephantiasis and hydrocele). Mass treatment with antifilarial drugs is

Hubungan Kondisi Lingkungan dengan Kasus Filariasis di Masyarakat (Analisis Lanjut Hasil Riskesdas 2007

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Santoso Santoso

2013-02-01

Full Text Available Abstracts. Filariasis (elephantiasis disease in Indonesia is still a health problems, there are still areas with the patient chronic and acute. A total of 1553 villages in 647 health centers scattered in 231 districts in 26 provinces as the location of the endemic, with a number of chronic cases of 6233 people. Elimination program disease elephantiasis has been undertaken by the government, but until today there are still many areas with the number of microfilariae (Mf rate is still high (> 1%. One of the government's efforts in this regard Litbangkes RI in collecting basic data, including data filariasis is with the activities of the Basic Health Research (Riskesdas conducted simultaneously across Indonesia. Based on the results of data collection Riskesdas then further analysis is to look at the environmental conditions and demographic status associated with the incidence of filariasis. Based on the results of analysis show that there were a statistically significant relationship between the type of waste water reservoirs; types of sewage systems and types of livestock kept, the classification of villages with the incidence of filariasis.Keywords: riskesdas, filariasis, environmental, demographic status

Modelling Lymphatic Filariasis: Transmission and Control

NARCIS (Netherlands)

S. Swaminathan

2004-01-01

textabstractLymphatic filariasis (LF) is a mosquito borne parasitic disease of the tropics. Of the three species of parasites causing the disease, W. bancrofti transmitted by Culex quinquefasciatus is the most widely prevalent. Infection can lead to disabling chronic manifestations: lymphoedema,

SITUASI FILARIASIS DI PULAU ALOR PADA TAHUN 2006

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Sekar Tuti

2012-12-01

Full Text Available Background: In Alor District, a mass drug treatment using diethylcarbamazine citrat and albendazole has been done since 2002 by Alor District Health Office (DHO. Objective: To assess several aspects of filariasis situation and mass treatment program in this district. Methods: Primary data were collected cross sectionaly in one sentinel and one spot check villages. Secondary data such as DHO’s program, case management, and elimination activity were collected retrospectively using questionairs. Results: The results showed that in both villages microfilaria rate (Mf-rate were reduced from 2.1% to 0% and 3% to 0%, respectively. Only one chronic case was found, in a female student. Advocations to the District Authority, and Elimination Program Policy had been prepared by DHO with the support of related institutions. Training on microscopy diagnostic and case management were done by the Faculty of Medicine University of Indonesia in colaboration with the German Agency for Technical Cooperation. Conclusions: It is concluded that filariasis elimination program has been conducted succesfully in Alor island, eventhough in several villages Mf-rate remains >1%. Advocation to the District Authority has been done appropriately using an acurate baseline data of Mf-rate and knowledge-attidute-practice of the community agains filariasis. Field coordinator for mass drug administration, and case management in the hospital were well prepared. Recomendation: To obtain a consistent support from District Authority and participation from the community, advocation and health education programs should be done periodically. Preparedness of program management and human resourches in all administrative levels should be maintained to obtain maximum results. Key words: Filariasis, situation, Alor island, 2006

A PRELIMINARY STUDY OF MALAYAN FILARIASIS IN PUDING VILLAGE, JAMBI PROVINCE (SUMATERA, INDONESIA

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Sudomo M.

2012-09-01

Full Text Available Beberapa daerah di Propinsi Jambi akan dikembangkan menjadi daerah transmigrasi, satu di antara­nya adalah daerah Kumpeh yang terletak berdekatan dengan daerah endemik filariasis malayi. Desa yang paling dekat dengan lokasi transmigrasi tersebut adalah desa Puding. Penelitian pendahuluan tentang penyakit filariasis telah dikerjakan di desa Puding untuk mengetahui tingkat endemisitas, periodisitas B. malayi, fauna nyamuk, jenis nyamuk yang potensial menjadi vektor filariasis, hospes reservoir dan keadaan sosial-ekonomi-budaya penduduk setempat. Mf rate pada penduduk desa Puding adalah 18,7% dan dari B. malayi jenis subperiodiknokturna. Nyamuk yang tertangkap terdiri dari enam genera yaitu genus Anopheles, Aedes, Culex, Coquilletidia, Mansonia dan Tripteroides. Dari enam genera tersebut yang potensial untuk menjadi vektor filariasis adalah genus Mansonia dan ini didukung dengan diketemukannyd larva stadium L3 (infektif Brugia sp di tubuh nyamuk tersebut. Keadaan sosial-ekonomi-budaya, khususnya menyangkut adat istiadat dan kebiasaan penduduk setempat, telah dipelajari.

DISTRIBUTION AND PREVALENCE OF MALAYAN FILARIASIS IN SOUTH SULAWESI, INDONESIA

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Gandahusada S.

2012-09-01

Full Text Available Untuk mendapatkan gambaran distribusi dan prevalensi penyakit filariasis di daerah transmigrasi Sulawesi Selatan, telah dikumpulkan data survey yang diadakan oleh Dinas Kesehatan Propinsi dan Ka­bupaten pada tahun 1972, 1973, 1976 dan 1979. Data diperoleh dari 82 desa dari 3 kecamatan, Mangkutana, Nuha, dan Wotu. Infeksi filariasis pada penduduk asli di Mangkutana (9.7% lebih tinggi dari pada para transmigran (7.6%. Sedangkan pada penduduk asli di Nuha 3.6%, dan di Wotu 3.5%.

Quilúria Chyluria

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Gerusa Dreyer

2007-10-01

Full Text Available A ruptura ou fistulização de vasos linfáticos para o interior do sistema excretor urinário dá origem à quilúria, que tem na bancroftose a sua principal etiologia. Pode ser, raramente, também causada por neoplasia, malformação linfática, traumatismo abdominal, assim como outras doenças infecciosas como a tuberculose. Os autores propõem as diretrizes gerais para a condução do portador de "urina leitosa" em áreas endêmicas e não endêmicas de filariose bancroftiana. Ressaltam a importância dos exames de triagem e de outros mais sofisticados para uma investigação etiológica a partir da realização de anamnese e de exame físico criteriosos. Enfatizam a necessidade de que a doença deve ser conduzida através de uma abordagem mais abrangente, que compreenda, além da médica, a assistência social e a nutricional. Na grande maioria dos casos, o controle da quilúria está basicamente fundamentado na educação e na adequação do paciente a uma dieta hipolipídica/hiperprotéica e rica em líquidos.The rupture or fistulization of lymph vessels into the urinary system, known as chyluria (milky urine, is caused mainly by bancroftian filariasis. On rare occasions chyluria may also be caused by neoplasia, lymphatic malformation, abdominal trauma, as well as other infectious diseases such as tuberculosis. The authors proposed general guidelines to manage patients suffering from milky urine in Bancroftian filariasis endemic and non-endemic areas. They emphasized the importance of a careful diagnostic process accomplished using screening procedures, evaluating a detailed history of illness and performing a careful physical examination, targeting on the most suitable diagnostic tools for each case. In addition, they emphasized the need to manage the patient from a broader perspective, which goes beyond the medical aspect, involving also social and nutritional contexts. In the great majority of cases, controlling chyluria is

Environment Biological and Health Care Efforts Influenced of Lymfatic Filariasis Incidence, Sarmi Distric

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Mina Sipayung

2014-05-01

District Sarmi is the most endemic area of filariasis in Papua which has rate of microfilaria (mf (47.06% up to the year 2012. In the Province Papua filarial worm is Wuchereria bancrofti and is transmitted through the bite of a mosquito vectors. Lymphatic filariasis does not cause death, but in chronic cases it causes disability, psychosocial problems, stigma, and decreased productivity. This study was aimed to analyze environment biological and health care efforts that influence the incidence of lymphatic filariasis. This study used case-control method. Samples comprised 32 case samples (mf + and 32 control samples (mf-. Primary data were collected through interviews and observation. Data were analyzed using Chi-Square and continued with multivariate Logistic Regression. Statistical analysis obtained indicated two variables on the incidence of lymphatic filariasis limfatik in District Sarmi (health care efforts pvalue = 0.002, OR: 7.779, as well as the biological environment pvalue= 0.008, OR: 5.841. Significant variables were health services with sub-variables promotion, prevention and the environmental biology. Suggestion: Mosquito bites should be avoided, the vector should be controlled through mutual cooperation and health promotion should be implemented. Keywords: Wuchereria bancrofti, lymphatic filariasis, vector, health care,                         Sarmi Distric

A complexidade do custo socioeconômico da filariose linfática The complexity of the socioeconomic costs of lymphatic filariasis

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Denise Mattos

2008-08-01

Full Text Available A falta de conhecimento do impacto socioeconômico das diversas doenças é, geralmente, um dos maiores obstáculos para a obtenção de verbas para investimentos em pesquisa aplicada, assim como para iniciar a implementação de programas de controle necessários aos países em desenvolvimento. Os autores analisam e ressaltam aspectos relevantes da complexidade de quantificação do impacto socioeconômico da filariose linfática e enfatizam as lacunas existentes em algumas áreas do conhecimento, que ainda não foram devidamente exploradas para os portadores da doença. Aos dados de literatura aliam os ecos do aprendizado adquirido através do atendimento de pacientes portadores de infecção e doença bancroftiana em serviço terciário de referência do Núcleo de Ensino Pesquisa e Assistência em Filariose (NEPAF, Recife, Brasil. O impacto social, no seu sentido mais abrangente, mostra indícios fortes de perdas na qualidade de vida dos pacientes, infelizmente ainda pouco documentadas e, até certo ponto, de muito difícil contabilização, pelo tão peculiar abandono social das comunidades endêmicas.Lack of knowledge of the socioeconomic impact of various diseases is generally one of the biggest obstacles to obtaining funds for investment in applied research and for starting to implement control programs that are needed in developing countries. The authors analyze and emphasize important aspects of the complexity of quantifying the socioeconomic impact of lymphatic filariasis. They highlight the gaps that exist within some fields of knowledge and that these gaps have still not been properly explored with regard to individuals with this disease. They bring together the data in the literature and echoes from their own experience gained through caring for patients with Bancroftian infection and disease at a tertiary referral service (NEPAF - Filariasis Care, Research and Teaching Center, Recife, Brazil. The social impact, in its broadest

Knowledge, attitudes and perceptions regarding lymphatic filariasis: study on systematic noncompliance with mass drug administration

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Silvia Cabral

Full Text Available ABSTRACT The aim of this study was to investigate the epidemiological characteristics, antigenic profile, perceptions, attitudes and practices of individuals who have been systematically non-compliant in mass drug administration (MDA campaigns targeting lymphatic filariasis, in the municipality of Olinda, State of Pernambuco, Northeastern Brazil. A pretested questionnaire was used to obtain information on socioenvironmental demographics, perceptions of lymphatic filariasis and MDA, and reasons for systematic noncompliance with treatment. A rapid immunochromatographic test (ICT was performed during the survey to screen for filariasis. It was found that the survey subjects knew about filariasis and MDA. Filariasis was identified as a disease (86.2% and 74.4% associated it with the presence of swelling in the legs. About 80% knew about MDA, and the main source of information was healthcare workers (68.3%. For men the main reasons for systematic noncompliance with MDA were that “the individual had not received the medication” (p=0.03 and for women “the individual either feared experiencing adverse reactions”. According to the ICT, the prevalence of lymphatic filariasis was 2%. The most important causes of systematic noncompliance were not receiving the drug and fear of side-effects. For successful implementation of MDA programs, good planning, educational campaigns promoting the benefits of MDA, adoption of measures to minimize the impact of adverse effects and improvement of drug distribution logistics are needed.

EVALUASI KEBIJAKAN PROGRAM PEMBERANTASAN FILARIASIS DI KABUPATEN TANAH BUMBU PROVINSI KALIMANTAN SELATAN

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Lukman Waris

2012-11-01

Full Text Available Elephantiasis in this lime has still become the problem of trensetter health of society these days. This disease can be catching and have the character of chronical which because of worm of filaria attacking lymph gland and channel causing and lymphangitis of elephantiasis. Borneo South Province, counted 13 Sub-Province/town (100% expressed as Filariasis endemis among others in Tanah Bumbu Sub Province. Target of this research is to know policy of execution of filaria eliminasi in Tanah Bumbu Sub-Province and also applying of strategy of eliminasi mount District and factors which and resistor of PSP society of endemis filariasis. This Research methode is observasional and conducted to organizer of program and also taker of policy of Tanah Bumbu Sub-Province (study qualitative and quantitative study's chosen society by using transversal crosscut Desain study (cross secsional by statistical analysis. Result of research indicate that all taker of policy is not to know surely case picture of filariasis in Tanah Bumbu Sub-Province, so that cannot do resource allocation and over come take action in eradication of filariasis. Result of assessment of knowledge of attitude and behavior of responder, productive age (26-35 year though living many as farmer with education of finish mean of SMA more is owning of knowledge, positive behavior and attitude if compared to other age group. Pursuant to statistical analysis of productive age group at most counselling terpapar by officer of health so that they more is knowing of disease of filaria in general. Key words: filariasis, study policy, tanah bumbu sub province

Applications of Self-Organising Map (SOM) for prioritisation of endemic zones of filariasis in Andhra Pradesh, India.

Science.gov (United States)

Murty, Upadhayula Suryanaryana; Rao, Mutheneni Srinivasa; Sriram, K; Rao, K Madhusudhan

2011-01-01

Entomological and epidemiological data of Lymphatic Filariasis (LF) was collected from 120 villages of four districts of Andhra Pradesh, India. Self-Organising Maps (SOMs), data-mining techniques, was used to classify and prioritise the endemic zones of filariasis. The results show that, SOMs classified all the villages into three major clusters by considering the data of Microfilaria (MF) rate, infection, infectivity rate and Per Man Hour (PMH). By considering the patterns of cluster, appropriate decision can be drawn for each parameter that is responsible for disease transmission of filariasis. Hence, SOM will certainly be a suitable tool for management of filariasis. The detailed application of SOM is discussed in this paper.

Lymphatic filariasis control in Tanga Region, Tanzania

DEFF Research Database (Denmark)

Simonsen, Paul Erik; Derua, Yahya A.; Magesa, Stephen M.

2014-01-01

BackgroundLymphatic filariasis (LF) control started in Tanga Region of Tanzania in 2004, with annual ivermectin/albendazole mass drug administration (MDA). Since then, the current project has monitored the effect in communities and schools in rural areas of Tanga District. In 2013, after 8 rounds...

Deteksi Brugia malayi pada Armigeres subalbatus dan Culex quinquefasciatusyang diinfeksikan darah penderita filariasis dengan metode PCR

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Yahya Yahya

2015-01-01

Full Text Available Abstract. Pemayungdistricts, Batanghari regency of Jambi province classified as filariasis endemic areas in Jambi province since the Mf rate reached 1.5% in 2011. A study was conducted to identify Brugia malayi on experimentally infected Ar. subalbatus and Cx. quinquefasciatus. An experimental study was performed with completely randomized design and six repetitions. Standard of treatment in this study was time (hours that selected for mosquitoes to bite the patients with filariasis (experimental infection. Selected time is at 9.00 a.m, 5.00 p.m, 9.00 p.m, and at 1.00 a.m. The results showed that filarial L3 larvae did not found on Ar. subalbatus and Cx. quinquefasciatus mosquitoes during surgery at day 11th to 13th after infection. Density of microfilariae in the blood of humans as a source of infection was 17 microfilariae per 20 micro liter blood. Otherwise, after detection by PCR, our study found positive B.malayi on Cx. quinquefasciatus thorax and proboscis. It indicates that Cx. quinquefasciatusas potential vector of B.malayi filariasis compared to Ar. subalbatus. Keywords: PCR, filariasis, Armigeres subalbatus, Culex quinquefasciatus, Brugia malayi   Abstrak. Kecamatan Pemayung Kabupaten Batanghari Provinsi Jambi merupakan wilayah endemis filariasis di Provinsi Jambi Karena angka Mf rate mencapai 1,5% pada tahun 2011. Penelitian ini untuk mengetahui tingkat kerentanan nyamuk Ar. subalbatus dan Cx. quinquefasciatus terhadap infeksi B. malayi subperiodik nokturna yang dilakukan pada tahun 2013, sehingga dapat dianalisis potensi nyamuk tersebut sebagai vektor filariasis di lokasi penelitian. Desain penelitian adalah eksperimental dengan rancangan acak lengkap dan enam kali pengulangan. Variabel perlakuan dalam penelitian ini adalah waktu (jam yang dipilih untuk menggigitkan nyamuk pada penderita filariasis (infeksi percobaan. Waktu yang dipilih adalah pukul 09.00 WIB, pukul 17.00 WIB, pukul 21.00 WIB dan pukul 01.00 WIB. Hasil penelitian

Perceptions, knowledge, attitudes and practices for the prevention and control of lymphatic filariasis in Conakry, Republic of Guinea.

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Kouassi, Bernard L; Barry, Aboulaye; Heitz-Tokpa, Kathrin; Krauth, Stefanie J; Goépogui, Andre; Baldé, Mamadou S; Barry, Oumar; Niamey, Marie L; Bockarie, Moses J; Koudou, Benjamin G; Utzinger, Jürg

2018-03-01

Little is known about the perceptions, attitudes and practices of lymphatic filariasis in Conakry, Republic of Guinea. Yet, such knowledge is important for an optimal design and implementation of setting-specific prevention and control measures. We conducted a cross-sectional study using a mixed methods approach. Qualitative data related to people's general experience with lymphatic filariasis, their perception of the causes of the disease, the onset of elephantiasis, care-seeking behaviour and the socioeconomic impact of lymphatic filariasis were collected through in-depth interviews with 85 respondents. Quantitative data related to strategies for prevention and the knowledge of the causes of the disease were collected by interviewing 429 people. A total of 514 individuals (313 females and 201 males), aged 10-84 years, participated. Most participants were well aware of lymphatic filariasis and they recognized the disease mainly by its disfiguring manifestation, collectively termed "elephantiasis" or "leg-swelling disease". Morbidity patterns due to filarial infection showed an increase with age (from 30 to 50 years) independent of sex. Most patients with lymphatic filariasis abandoned their jobs (73.9%) or sought other work (21.7%). The main perceived causes of acquiring lymphatic filariasis were of supernatural origin (as stated by 8.7% of patients and 5.7% of healthy subjects), while mosquito bites were mentioned by fewer participants (4.3% of patients and 4.2% of healthy subjects). A number of other causes were reported that relate to both medical and non-medical conceptions. The study also identified socioeconomic impairments and stigmatization due to elephantiasis. Taken together, community perception of lymphatic filariasis in Conakry is influenced by sociocultural conceptions. Appropriate health education campaigns aimed at enhancing community understanding of the transmission of lymphatic filariasis are required to increase the success of mass drug

Assessing Progress in Reducing the At-Risk Population after 13 Years of the Global Programme to Eliminate Lymphatic Filariasis

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Hooper, Pamela J.; Chu, Brian K.; Mikhailov, Alexei; Ottesen, Eric A.; Bradley, Mark

2014-01-01

Background In 1997, the World Health Assembly adopted Resolution 50.29, committing to the elimination of lymphatic filariasis (LF) as a public health problem, subsequently targeted for 2020. The initial estimates were that 1.2 billion people were at-risk for LF infection globally. Now, 13 years after the Global Programme to Eliminate Lymphatic Filariasis (GPELF) began implementing mass drug administration (MDA) against LF in 2000—during which over 4.4 billion treatments have been distributed in 56 endemic countries—it is most appropriate to estimate the impact that the MDA has had on reducing the population at risk of LF. Methodology/Principal Findings To assess GPELF progress in reducing the population at-risk for LF, we developed a model based on defining reductions in risk of infection among cohorts of treated populations following each round of MDA. The model estimates that the number of people currently at risk of infection decreased by 46% to 789 million through 2012. Conclusions/Significance Important progress has been made in the global efforts to eliminate LF, but significant scale-up is required over the next 8 years to reach the 2020 elimination goal. PMID:25411843

Using kernel density estimates to investigate lymphatic filariasis in northeast Brazil

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Medeiros, Zulma; Bonfim, Cristine; Brandão, Eduardo; Netto, Maria José Evangelista; Vasconcellos, Lucia; Ribeiro, Liany; Portugal, José Luiz

2012-01-01

After more than 10 years of the Global Program to Eliminate Lymphatic Filariasis (GPELF) in Brazil, advances have been seen, but the endemic disease persists as a public health problem. The aim of this study was to describe the spatial distribution of lymphatic filariasis in the municipality of Jaboatão dos Guararapes, Pernambuco, Brazil. An epidemiological survey was conducted in the municipality, and positive filariasis cases identified in this survey were georeferenced in point form, using the GPS. A kernel intensity estimator was applied to identify clusters with greater intensity of cases. We examined 23 673 individuals and 323 individuals with microfilaremia were identified, representing a mean prevalence rate of 1.4%. Around 88% of the districts surveyed presented cases of filarial infection, with prevalences of 0–5.6%. The male population was more affected by the infection, with 63.8% of the cases (P<0.005). Positive cases were found in all age groups examined. The kernel intensity estimator identified the areas of greatest intensity and least intensity of filarial infection cases. The case distribution was heterogeneous across the municipality. The kernel estimator identified spatial clusters of cases, thus indicating locations with greater intensity of transmission. The main advantage of this type of analysis lies in its ability to rapidly and easily show areas with the highest concentration of cases, thereby contributing towards planning, monitoring, and surveillance of filariasis elimination actions. Incorporation of geoprocessing and spatial analysis techniques constitutes an important tool for use within the GPELF. PMID:22943547

Short report: documentation of iodine deficiency in Haitian schoolchildren: implication for lymphatic filariasis elimination in Haiti.

Science.gov (United States)

Beach, M J; Streit, T G; Houston, R; May, W A; Addiss, D G; Lammie, P J

2001-01-01

In this study we documented unexpected moderate-to-severe iodine deficiency in Haitian schoolchildren although they live in a coastal community where presumably they have access to iodine-containing seafood. This fact combined with the lack of an iodized salt supply and endemic lymphatic filariasis makes community distribution of diethylcarbamazine-fortified, iodized salt an attractive strategy for elimination of lymphatic filariasis and iodine deficiency disorders in this area of Haiti. Combining lymphatic filariasis elimination with other public health interventions is one strategy to increase its public health benefit and maximize the impact of limited public health resources.

Faktor Lingkungan dan Perilaku Masyarakat yang Berhubungan dengan Kejadian Filariasis di Kecamatan Muara Pawan Kabupaten Ketapang Provinsi Kalimantan Barat

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Wary Purnama

2017-03-01

Full Text Available Judul : Faktor Lingkungan dan Perilaku Yang Berhubungan Dengan Kejadian Filariasis di Kecamatan Muara Pawan Kabupaten Ketapang, Kalimantan Barat Latar belakang: Tahun 2015, terdapat 79 kasus filariais di Kecamatan Muara Pawan Kabupaten Ketapang dengan micrifilaria rate sebesar 2,5%. Penelitian ini bertujuan untuk menganalisis hubungan antara faktor lingkungan dan perilaku dengan kejadian filariasis, serta mengidentifikasi spesies nnyamuk yang diduga sebagai vektor filariasis. Metode: Penelitian ini merupakan penelitian observasional dengan rancangan case control. Subyek penelitian terdiri dari 32 kasus dan 32 kontrol. Pengumpulan data dilakukan dengan wawancara dan observasi. Analisis data menggunakan uji Chi-square dengan taraf signifikasi 0,05. Hasil: Dari 419 nyamuk yang ditangkap. Tidak ditemukan adanya larva cacing dalam tubuh nyamuk. Hasil identifikasi nyamuk menemukan 6 spesies yaitu Anopheles letifer, Mansonia uniformis, Culex tritaeniorhyncus, Culex vishnui, Culex cressipes, and Mansonia annulifera. Analisis statistik menunjukkan bahwa keberadaan breeding places, resting places, pengetahuan, dan kebiasaan keluar pada malam hari merupakan faktor risiko kejadian filariasis di Kecamatan Muara Pawan Kalimantan Barat. Simpulan: Faktor lingkungan dan perilaku masyarakat merupakan faktor risiko kejadian filariasis di Kecamatan Muara Pawan Kabupaten Ketapang.   ABSTRACT Title: Enviromental and Community Behaviour Factors Associated with the incidence of Lymphatic Filariasis in Muara Pawan Distrct of Ketapang Regency, West Kalimantan Background: In the year of 2015, there were 79 cases of filariasis in Ketapang Regency and in Muara Pawan District, in particular, from 32 cases who contracted microfilariae resulted in Mf rate = 2,5% while for prevalence rate (PR = 2,18. The objectives of this research were to analyze correlation between evironmental and community behavioral factors associated with cases of filariasis as well as to identify the

Filariasis in Pregnancy: Prevalent yet Less‑known Global Health ...

African Journals Online (AJOL)

2016 Journal of Basic and Clinical Reproductive Sciences | Published by Wolters Kluwer ‑ Medknow. 107 ... The aim of this article is to present a rare case of incidental filariasis in ... There was nonpitting edema in both the limbs and pitting.

KOMPOSISI SPESIES DAN DOMINASI NYAMUK CULEX DI DAERAH ENDEMIS FILARIASIS LIMFATIK DI KELURAHAN PABEAN KOTA PEKALONGAN

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Tri Ramadhani

2012-11-01

Full Text Available Filariasis is one of the communicable disease which is caused by infestation of Filaria wonn. The disease is transmitted by various mosquitoes. Pabean village was one of the endemic area in Pekalongan city with lymphatic filariasis problem (microfilariae rate >1 %. The research aimed to get species and dominan potencial vector filariasis and breeding place.The reseach was an observational study which used cross sectional design. The activity were mosquitoes, larve dipper and pupa collection from August until December 2007. The mosquitoes collection was done twice a week by landing collection and light trap with dry ice.The result showed that the species culex mosquitoes found 19.229, consisted of four species that is Cx.quinquefasciatus, Cx.bitaeniorhynchus, Cx. tritaeniorhynchus, and Cx. vishnui. Mosquito of Cx.quinquefasciatus most dominantly found at all of way of arrest and known as mosquito of vector potential of lymphatic filariasis in Pabean village. Especial breeding place of Cx.quinquefasciatus is water polution and very bad sanitation. The larval density was more than 100 of dipper.

Seventh meeting of the Global Alliance to Eliminate Lymphatic Filariasis: reaching the vision by scaling up, scaling down, and reaching out

Science.gov (United States)

2014-01-01

This report summarizes the 7th meeting of the Global Alliance to Eliminate Lymphatic Filariasis (GAELF), Washington DC, November 18–19, 2012. The theme, “A Future Free of Lymphatic Filariasis: Reaching the Vision by Scaling Up, Scaling Down and Reaching Out”, emphasized new strategies and partnerships necessary to reach the 2020 goal of elimination of lymphatic filariasis (LF) as a public-health problem. PMID:24450283

Prevalence of depression and associated clinical and socio-demographic factors in people living with lymphatic filariasis in Plateau State, Nigeria.

Science.gov (United States)

Obindo, James; Abdulmalik, Jibril; Nwefoh, Emeka; Agbir, Michael; Nwoga, Charles; Armiya'u, Aishatu; Davou, Francis; Maigida, Kurkat; Otache, Emmanuel; Ebiloma, Ajuma; Dakwak, Samuel; Umaru, John; Samuel, Elisha; Ogoshi, Christopher; Eaton, Julian

2017-06-01

Lymphatic filariasis is a chronic, disabling and often disfiguring condition that principally impacts the world's poorest people. In addition to the well-recognised physical disability associated with lymphedema and hydrocele, affected people often experience rejection, stigma and discrimination. The resulting emotional consequences are known to impact on the quality of life and the functioning of the affected individuals. However, the management of this condition has focused on prevention and treatment through mass drug administration, with scant attention paid to the emotional impact of the condition on affected individuals. This study aimed to determine the prevalence and severity of depression among individuals with physical disfigurement from lymphatic filariasis in Plateau State, Nigeria. A cross-sectional 2-stage convenience study was conducted at 5 designated treatment centers across Plateau State, Nigeria. All available and consenting clients with clearly visible physical disfigurement were recruited. A semi-structured socio-demographic questionnaire, Rosenberg Self-esteem and a 9-item Patient Health Questionnaire (PHQ-9) were administered at the first stage. Those who screened positive (with a PHQ-9 score of five and above) were further interviewed using the Depression module of the Composite International Diagnostic Interview (CIDI). Ninety-eight individuals met the criteria and provided consent. Twenty percent of the respondents met criteria for depression, with the following proportions based on severity: Mild (42.1%), Moderate (31.6%) and Severe (26.3%). History of mental illness (OR 40.83, p = 0.008); Median duration of the illness was 17 years (IQR 7.0-30 years) and being unemployed (OR 12.71, p = 0.003) were predictive of depression. High self-esteem was negatively correlated (OR 0.09, pdepression is high among individuals with lymphatic filariasis and depression in sufferers is associated with low self-esteem and low levels of life satisfaction.

Prevalence of depression and associated clinical and socio-demographic factors in people living with lymphatic filariasis in Plateau State, Nigeria.

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James Obindo

2017-06-01

Full Text Available Lymphatic filariasis is a chronic, disabling and often disfiguring condition that principally impacts the world's poorest people. In addition to the well-recognised physical disability associated with lymphedema and hydrocele, affected people often experience rejection, stigma and discrimination. The resulting emotional consequences are known to impact on the quality of life and the functioning of the affected individuals. However, the management of this condition has focused on prevention and treatment through mass drug administration, with scant attention paid to the emotional impact of the condition on affected individuals. This study aimed to determine the prevalence and severity of depression among individuals with physical disfigurement from lymphatic filariasis in Plateau State, Nigeria.A cross-sectional 2-stage convenience study was conducted at 5 designated treatment centers across Plateau State, Nigeria. All available and consenting clients with clearly visible physical disfigurement were recruited. A semi-structured socio-demographic questionnaire, Rosenberg Self-esteem and a 9-item Patient Health Questionnaire (PHQ-9 were administered at the first stage. Those who screened positive (with a PHQ-9 score of five and above were further interviewed using the Depression module of the Composite International Diagnostic Interview (CIDI.Ninety-eight individuals met the criteria and provided consent. Twenty percent of the respondents met criteria for depression, with the following proportions based on severity: Mild (42.1%, Moderate (31.6% and Severe (26.3%. History of mental illness (OR 40.83, p = 0.008; Median duration of the illness was 17 years (IQR 7.0-30 years and being unemployed (OR 12.71, p = 0.003 were predictive of depression. High self-esteem was negatively correlated (OR 0.09, p<0.004.Prevalence of depression is high among individuals with lymphatic filariasis and depression in sufferers is associated with low self-esteem and low

Epidemiological assessment of neglected diseases in children: lymphatic filariasis and soil-transmitted helminthiasis

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Ana M. Aguiar-Santos

2013-05-01

Full Text Available Objective: To report the prevalence of lymphatic filariasis and intestinal parasitic infections in school-aged children living in a filariasis endemic area and discuss about the therapeutic regimen adopted in Brazil for the large-scale treatment of filariasis. Methods: A cross-sectional study including 508 students aged 5-18 years old, enrolled in public schools within the city of Olinda, Pernambuco. The presence of intestinal parasites was analyzed using the Hoffman, Pons and Janer method on 3 stool samples. The diagnosis of filarial infection was performed using the rapid immunochromatographic technique (ICT for the antigen, and the polycarbonate membrane filtration for the presence of microfilariae. Descriptive statistics of the data was performed using EpiInfo version 7. Results: The prevalence of filariasis was 13.8% by ICT and 1.2% by microfilaraemia, while intestinal parasites were detected in 64.2% of cases. Concurrent diagnosis of filariasis and intestinal parasites was 9.4%, while 31.5% of students were parasite-free. Among individuals with intestinal parasites, 55% had one parasite and 45% had more than one parasite. Geohelminths occurred in 72.5% of the parasited individuals. In the group with filarial infection the prevalence of soil-transmitted helminthiasis was 54.5%. Conclusions: The simultaneous diagnosis of filariasis and intestinal parasites as well as the high frequency of geohelminths justify the need to reevaluate the treatment strategy used in the Brazilian filariasis large-scale treatment program. Resumo: Objetivo: Descrever a prevalência de infecção filarial e de parasitoses intestinais em escolares numa área endêmica de filariose e refletir sobre a opção terapêutica utilizada no Brasil no tratamento coletivo para filariose. Métodos: Estudo transversal envolvendo 508 alunos na faixa etária de 5-18 anos cadastrados em escolas públicas do município de Olinda-PE. Realizou-se a investigação da parasitose

The Distribution of Culex spp (Diptera: Culicidae in Selected Endemic Lymphatic Filariasis Villages in Bandung District West Java Indonesia

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Endang Puji Astuti

2017-12-01

Full Text Available Abstrak. Data entomologis terkait aspek bionomik dan distribusi nyamuk vektor lymphatic filariasis di Kabupaten Bandung masih sangat sedikit meskipun kabupaten ini sudah mengimplementasikan POPM Filariasis dari tahun 2009. Tujuan penelitian adalah mengindentifikasi spesies nyamuk potensial penular lymphatic filariasis dan habitatnya di wilayah endemis filariasis yaitu Kecamatan Majalaya, Kabupaten Bandung. Survei dilaksanakan selama 2 bulan yaitu September – Oktober 2013 di dua desa Kecamatan Majalaya. Kegiatannya adalah pencidukan larva (termasuk plotting habitat, salinitas, temperatur air, pH, penangkapan nyamuk dewasa menggunakan metode human landing (dalam dan luar rumah serta resting (dinding rumah dan kandang ternak. Hasil penangkapan nyamuk memperoleh enam spesies yang berhasil diidentifikasi. Culex quinquefasciatus dan Cx. tritaeniorhynchus adalah nyamuk yang dominan tertangkap dengan puncak gigitan antara jam 21.00-01.00 WIB. Terdapat lima tempat perkembangbiakan potensial yang teramati disekitar desa tersebut yang terdiri dari kolam ikan yang terbengkalai dan persawahan dengan salinitas 0‰, temperatur air 28,5-29°C, pH 6-7. Meskipun MHD dan MBR vektor filariasis yaitu Cx. quinquefasciatus di wilayah tersebut relatif rendah, penularan masih dapat terjadi karena didukung dengan kondisi lingkungan dan keberadaan nyamuk vektor tersebut di wilayah iniKata kunci: lymphatic filariasis; tempat perkembangbiakan; Cx. quinquefasciatus; kepadatan, BandungAbstract. Bandung district has been implemented mass drug administration (MDA program since 2009, but little is known about entomological data especially about bionomic aspects and distribution of lymphatic filariasis (LF mosquito vectors. This study was aimed to identify potential LF mosquito species and its potential breeding sites in two LF endemic villages in Majalaya, Bandung district. The observational study was conducted in September-October 2013. Mosquito larvae were collected by a

A pilot study on the status of lymphatic filariasis in a rural community of Bihar.

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Das, V N R; Siddiqui, N A; Kumar, N; Verma, N; Verma, R B; Dinesh, D S; Kar, S K; Das, P

2006-03-01

A pilot study of lymphatic filariasis was conducted in two contiguous villages of Patna district in Bihar situated at the side of the river Ganges, known to be endemic for lymphatic filariasis, to study present status of transmission parameters of filariasis. Of the 1872 persons examined, 8.4% were found asymptomatic but microfilaraemic. Morbidity pattern due to filarial infection showed an increase with advancement of age and significantly high in males as compared to female (p < 0.001). Acute and chronic filarial disease was observed as 0.5% and 9% respectively. Microfilaria was found in 10% of acute and 11.2% of chronic filarial cases. The Mf rate was found to be 9.9% in males and 9.0% in females respectively. The parasite species was identified as W. bancrofti. The vector fauna surveyed show highest prevalence of vector species of Cx. quinquefasciatus (43%) in both domestic as well as predomestic area in the community. Other species like Cx. vishnui and Ma. uniformis were also seen. Each household and predomestic area was searched for mosquito fauna at night. The infection rate in vectors was found to be 14% and infectivity rate (L3) was 8%. The filariasis cases detected in the study were treated with 12 days course of DEC 6 mg/kg body weight.

Relationship of Environmental Conditions to Filariasis Cases in Community (An Advanced Analysis of Basic Health Research 2007

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Santoso

2011-06-01

Full Text Available Filariasis (elephantiasis disease in Indonesia is still a health problems, there are still areas with the patient chronic and acute. A total of 1553 villages in 647 health centers scattered in 231 districts in 26 provinces as the location of the endemic, with a number of chronic cases of 6233 people. Elimination program disease elephantiasis has been undertaken by the government, but until today there are still many areas with the number of microfilariae (Mf rate is still high (> 1%. One of the government's efforts in this regard Litbangkes RI in collecting basic data, including data filariasis is with the activities of the Basic Health Research (Riskesdas conducted simultaneously across Indonesia. Based on the results of data collection Riskesdas then further analysis is to look at the environmental conditions and demographic status associated with the incidence of filariasis. Based on the results of analysis show that there were a statistically significant relationship between the type of waste water reservoirs; types of sewage systems and types of livestock kept, the classification of villages with the incidence of filariasis.

SURVEI DARAH JARI FILARIASIS DI DESA BATUMARTA X KEC. MADANG SUKU III KABUPATEN OGAN KOMERING ULU (OKU TIMUR, SUMATERA SELATAN TAHUN 2012

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R. Irpan Pahlepi

2015-01-01

Full Text Available AbstrakFilariasis atau penyakit kaki gajah adalah golongan penyakit menular yang disebabkan oleh cacing filaria  yang  ditularkan  melalui  berbagai  jenis  nyamuk.  Penyebaran  filariasis  hampir  meliputi  seluruh wilayah di Indonesia termasuk Kabupaten Ogan Komering Ulu (OKU Timur. Angka kesakitan filarisis di Kabupaten OKU Timur tahun 2007 sebesar 1,05%. Kegiatan pengobatan massal di Kabupaten OKU Timur belum pernah dilakukan sampai saat ini, sehingga perlu dilakukan penelitian yang bertujuan untuk mengetahui tingkat penyebaran penyakit filariasis. Penelitian ini merupakan penelitian survei dengan desain potong lintang. Pengambilan dan pemeriksaan sediaan darah jari dilakukan pada malam hari dimulai pukul 19.00 WIB. Jumlah penduduk yang diperiksa sebanyak 502. Hasil pemeriksaan diperoleh 4 orang positif mikrofilaria (Mf_ rate 0,8% dengan spesies Brugia  malayi  dan  kepadatan  rata-rata  200mf/ml.  Seluruh  kasus  yang  ditemukan  merupakan  kasus baru. Hasil penelitian ini menunjukkan bahwa penularan filariasis masih terjadi di Kabupaten OKU Timur sehingga perlu adanya pengobatan massal untuk mencegah penularan lebih lanjut.Kata kunci : Filariasis, Brugia malayi, Survei darah jari, OKU TimurAbstractFilariasis or elephantiasis is an infectious diseases caused by filarial worms that transmitted by various species of mosquitoes. Filariasis distributions almost covers all districts in Indonesia including East Ogan Komering Ulu (OKU. Filarisais morbidity in East OKU regency in 2007 was 1.05 %. Mass treatment in the district of East OKU have not been done yet, so it is necessary to do a research that aim to determine the prevalen of filariasis. This study is a cross-sectional survey design. Collection and examination of finger’s blood was done at night starting at 19:00. Number of people examined were 502. Examination results obtained 4 positive microfilariae (Mf_ rate 0.8 % of Brugia malayi and the average density of 200

Diversity and transmission competence in lymphatic filariasis vectors in West Africa, and the implications for accelerated elimination of Anopheles-transmitted filariasis

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de Souza Dziedzom K

2012-11-01

Full Text Available Abstract Lymphatic Filariasis (LF is targeted for elimination by the Global Programme for the Elimination of Lymphatic Filariasis (GPELF. The strategy adopted is based on the density dependent phenomenon of Facilitation, which hypothesizes that in an area where the vector species transmitting Wuchereria bancrofti are Anopheles mosquitoes, it is feasible to eliminate LF using Mass Drug Administration (MDA because of the inability of Anopheles species to transmit low-density microfilaraemia. Even though earlier studies have shown Anopheles species can exhibit the process of Facilitation in West Africa, observations point towards the process of Limitation in certain areas, in which case vector control is recommended. Studies on Anopheles species in West Africa have also shown genetic differentiation, cryptic taxa and speciation, insecticide resistance and the existence of molecular and chromosomal forms, all of which could influence the vectorial capacity of the mosquitoes and ultimately the elimination goal. This paper outlines the uniqueness of LF vectors in West Africa and the challenges it poses to the 2020 elimination goal, based on the current MDA strategies.

Parasitological profile of perstans filariasis among blood donors in ...

African Journals Online (AJOL)

The study was conducted at Ile – Ife, in Osun State Southwest Nigeria between March and September, 2009 with a view to determine the prevalence of blood filariasis among blood donors. The blood samples of 250 blood donors were parasitologically examined directly with wet preparation, while the thick and thin films ...

Identification and characterization of nematode specific protective epitopes of Brugia malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis.

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Madhumathi, Jayaprakasam; Prince, Prabhu Rajaiah; Anugraha, Gandhirajan; Kiran, Pote; Rao, Donthamsetty Nageswara; Reddy, Maryada Venkata Rami; Kaliraj, Perumal

2010-07-12

Although multi-epitope vaccines have been evaluated for various diseases, they have not yet been investigated for lymphatic filariasis. Here, we report for the first time identification of two immunodominant B epitopes (TRXP1 and TRXP2) from the antioxidant Brugia malayi thioredoxin by studying their immune responses in mice model and human subjects. TRXP1 was also found to harbor a T epitope recognized by human PBMCs and mice splenocytes. Further, the epitopic peptides were synthesized as a single peptide conjugate (PC1) and their prophylactic efficacy was tested in a murine model of filariasis with L3 larvae. PC1 conferred a significantly high protection (75.14%) (P TRX (63.03%) (P < 0.018) in experimental filariasis. Our results suggest that multi-epitope vaccines could be a promising strategy in the control of lymphatic filariasis.

Analisis Cakupan Obat Massal Pencegahan Filariasis Di Kabupaten Bandung Dengan Pendekatan Model Sistem Dinamik

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Mara Ipa

2016-07-01

Full Text Available Filariasis Preventive Mass Drug Administration (MDA program supposed to covered at least 65% of the target. According to the Indonesia’s program annual reports, the coverage from year of 2005-2009 are 28%-29%. Those coverage are still far below the expected coverage. Bandung Regency is one of 11 filariasis endemic areas in West Java that treatment coverage for four years (2009-2012 in a row is 70%, 62%, 64% and 68%. This study was an observational study with cross sectional study design studies. The study was conducted at the health center Cikaro Regency Bandung in 2013 to determine the variable leverage increase treatment coverage. The data collected in this study include primary data and secondary data. The primary data obtained through interviews of 200 respondents to the questionnaire and also through Focus Group Discussion (FGD. Secondary data include population and filariasis treatment coverage of data obtained from the agency terkait.Variabel levers determined through the analysis of dynamic system modeling software powersim. The results showed that the variable lever to increase the coverage of treatment is to reduce the negative impact of drug side effects, increasing the number of cadres and knowledge as well as increased monitoring activities of treatment. Increased treatment coverage can be done through the declaration take medicine in the empowering cadres.Filariasis Preventive Mass Drug Administration (MDA program supposed to covered at least 65% of the target. According to the Indonesia’s program annual reports, the coverage from year of 2005-2009 are 28%-29%. Those coverage are still far below the expected coverage. Bandung Regency is one of 11 filariasis endemic areas in West Java that treatment coverage for four years (2009-2012 in a row is 70%, 62%, 64% and 68%. This study was an observational study with cross sectional study design studies. The study was conducted at the health center Cikaro Regency Bandung in 2013 to

[Clinical microbiology laboratory and imported parasitic diseases].

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Martín-Rabadán, Pablo; Martínez-Ruiz, Rocío; Cuadros, Juan; Cañavate, Carmen

2010-12-01

Imported parasitosis represents an increasingly frequent diagnostic challenge for microbiology laboratories. A surge in immigration and international travel has led to a rise in the number of imported cases of parasitosis, and this trend is expected to continue in the future. The present article addresses this challenge by reviewing recommended diagnostic approaches and tests. Currently, microscopy is always recommended when analysing blood samples for parasites. If malaria is suspected, rapid antigen testing (including at least HRP2 antigen) should also be performed. The work-up for suspected leishmaniasis should include serology, culture, and in selected cases detection of antigen in urine. In suspected Chagas disease, two different serological tests should be performed. PCR for blood protozoa is highly sensitive, although it cannot be used to rule out Chagas disease, since this condition may be present without parasitemia. Accurate diagnosis of intestinal amebiasis usually requires PCR or antigen detection tests. In helminthiasis, traditional microscopy may need to be complemented with other tests, such as agar plate culture for strongyloidiasis, Og4C3 antigen detection for bancroftian filariasis, and antibody detection test for filariasis and schistosomiasis. Copyright © 2010 Elsevier España, S.L. All rights reserved.

Travel-related schistosomiasis, strongyloidiasis, filariasis, and toxocariasis: the risk of infection and the diagnostic relevance of blood eosinophilia

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Sonder Gerard J

2011-04-01

Full Text Available Abstract Background This study prospectively assessed the occurrence of clinical and subclinical schistosomiasis, strongyloidiasis, filariasis, and toxocariasis, and the screening value of eosinophilia in adult short-term travelers to helminth-endemic countries. Methods Visitors of a pre-travel health advice centre donated blood samples for serology and blood cell count before and after travel. Samples were tested for eosinophilia, and for antibodies against schistosomiasis, strongyloidiasis, filariasis, and toxocariasis. Previous infection was defined as seropositivity in pre- and post-travel samples. Recent infection was defined as a seroconversion. Symptoms of parasitic disease were recorded in a structured diary. Results Previous infection was found in 112 of 1207 subjects: schistosomiasis in 2.7%, strongyloidiasis in 2.4%, filariasis in 3.4%, and toxocariasis in 1.8%. Recent schistosomiasis was found in 0.51% of susceptible subjects at risk, strongyloidiasis in 0.25%, filariasis in 0.09%, and toxocariasis in 0.08%. The incidence rate per 1000 person-months was 6.4, 3.2, 1.1, and 1.1, respectively. Recent infections were largely contracted in Asia. The positive predictive value of eosinophilia for diagnosis was 15% for previous infection and 0% for recent infection. None of the symptoms studied had any positive predictive value. Conclusion The chance of infection with schistosomiasis, strongyloidiasis, filariasis, and toxocariasis during one short-term journey to an endemic area is low. However, previous stay leads to a cumulative risk of infection. Testing for eosinophilia appeared to be of no value in routine screening of asymptomatic travelers for the four helminthic infections. Findings need to be replicated in larger prospective studies.

Analisis Spasial Kejadian Filariasi di Kabupaten Demak Jawa Tengah

OpenAIRE

Nurjazuli Nurjazuli; Hanan Lanang Dangiran; Asty Awiyatul Bari'ah

2018-01-01

Latar Belakang: Filariasis merupakan salah satu penyakit tular vektor yang kurang mendapatkan perhatian, termasuk kelompok Neglected Tropical Diseases (NTDs). Kabupaten Demak merupakan salah satu wilayah di Propinsi Jawa Tengah  yang merupakan daerah endemis filarisis (mf rate>1%). Kejadian filarisis di daerah ini diduga berkaitan dengan kondisi lingkungan fisik dan biologis (nyamuk) yang mempunyai peran penting dalam penyebaran penyakit filarisis. Penelitian ini bertujuan untuk menemukan ada...

Data base management system for lymphatic filariasis--a neglected tropical disease.

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Upadhyayula, Suryanaryana Murty; Mutheneni, Srinivasa Rao; Kadiri, Madhusudhan Rao; Kumaraswamy, Sriram; Nelaturu, Sarat Chandra Babu

2012-01-01

Researchers working in the area of Public Health are being confronted with large volumes of data on various aspects of entomology and epidemiology. To obtain the relevant information out of these data requires particular database management system. In this paper, we have described about the usages of our developed database on lymphatic filariasis. This database application is developed using Model View Controller (MVC) architecture, with MySQL as database and a web based interface. We have collected and incorporated the data on filariasis in the database from Karimnagar, Chittoor, East and West Godavari districts of Andhra Pradesh, India. The importance of this database is to store the collected data, retrieve the information and produce various combinational reports on filarial aspects which in turn will help the public health officials to understand the burden of disease in a particular locality. This information is likely to have an imperative role on decision making for effective control of filarial disease and integrated vector management operations.

The NIH-NIAID Filariasis Research Reagent Resource Center.

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Michelle L Michalski

2011-11-01

Full Text Available Filarial worms cause a variety of tropical diseases in humans; however, they are difficult to study because they have complex life cycles that require arthropod intermediate hosts and mammalian definitive hosts. Research efforts in industrialized countries are further complicated by the fact that some filarial nematodes that cause disease in humans are restricted in host specificity to humans alone. This potentially makes the commitment to research difficult, expensive, and restrictive. Over 40 years ago, the United States National Institutes of Health-National Institute of Allergy and Infectious Diseases (NIH-NIAID established a resource from which investigators could obtain various filarial parasite species and life cycle stages without having to expend the effort and funds necessary to maintain the entire life cycles in their own laboratories. This centralized resource (The Filariasis Research Reagent Resource Center, or FR3 translated into cost savings to both NIH-NIAID and to principal investigators by freeing up personnel costs on grants and allowing investigators to divert more funds to targeted research goals. Many investigators, especially those new to the field of tropical medicine, are unaware of the scope of materials and support provided by the FR3. This review is intended to provide a short history of the contract, brief descriptions of the fiilarial species and molecular resources provided, and an estimate of the impact the resource has had on the research community, and describes some new additions and potential benefits the resource center might have for the ever-changing research interests of investigators.

Factors influencing drug uptake during mass drug administration for control of lymphatic filariasis in rural and urban Tanzania

DEFF Research Database (Denmark)

Kisoka, William J.; Simonsen, Paul Erik; Malecela, Mwelecele N.

2014-01-01

BACKGROUND: In most countries of Sub-Saharan Africa, control of lymphatic filariasis (LF) is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole. Treatment coverages are however often suboptimal for programmes to reach the goal of transmission interrupt......BACKGROUND: In most countries of Sub-Saharan Africa, control of lymphatic filariasis (LF) is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole. Treatment coverages are however often suboptimal for programmes to reach the goal of transmission...

Data base management system for lymphatic filariasis--a neglected tropical disease.

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Suryanaryana Murty Upadhyayula

Full Text Available BACKGROUND: Researchers working in the area of Public Health are being confronted with large volumes of data on various aspects of entomology and epidemiology. To obtain the relevant information out of these data requires particular database management system. In this paper, we have described about the usages of our developed database on lymphatic filariasis. METHODS: This database application is developed using Model View Controller (MVC architecture, with MySQL as database and a web based interface. We have collected and incorporated the data on filariasis in the database from Karimnagar, Chittoor, East and West Godavari districts of Andhra Pradesh, India. CONCLUSION: The importance of this database is to store the collected data, retrieve the information and produce various combinational reports on filarial aspects which in turn will help the public health officials to understand the burden of disease in a particular locality. This information is likely to have an imperative role on decision making for effective control of filarial disease and integrated vector management operations.

STUDI ENDEMISITAS FILARIASIS DI WILAYAH KECAMATAN PEMAYUNG, KABUPATEN BATANGHARI PASCA PENGOBATAN MASSAL TAHAP III

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Yahya Yahya

2013-05-01

Full Text Available Abstract Filariasis endemicity research in District Pemayung, Batanghari Regency Post-Mass Drug Administration Phase III has been implemented. The study aims to determine the prevalence of filariasis, microfilaria worm species, the periodicity, reservoir determination and evaluate the results of mass treatment activities that have been 3 times. The number of people who checked their blood preparation for the examination as many as 538. Blood sampling for the periodicity of the parasite examinations performed on 4 persons, each carried out blood sampling every 2 hours for 24 hours. People microfilariae with microfilariae positive number as many as 8 people to rate microfilariae (Mf rate 1.5%.. The highest parasite density of 17.493 per 20 cu mm of blood occurred at 1:00 am and decresing to 0,415 per 20 cu mm of blood at 07.00 am. The parasite was found in sub periodic nokturna 3 subjects and 1 subject was found only be found in the morning and afternoon. The results of examination of 12 cats and two monkeys were found two positive cats with Brugia malayi microfilariae. Cats that were examined and the positive was one house cat and one stray cat. The conclusion from this study showed that filariasis was still endemic with periodicity of microfilariae was sub periodic nokturna and was zoonotic. Recommendations of this study was that mass treatment  was done by giving the drug directly and took medicine in front of the officers, examination and treatment of microfilariae positive cats. Key words: microfilariae rate, periodicity, Brugia malayi, reservoir. Abstrak  Submit : 28-03-2012  Review : 04-04-2012 Review : 11-06-2012 revisi : 29–08-2012Penelitian untuk menentukan tingkat endemisitas filariasis di wilayah Kecamatan Pemayung, Kabupaten Batanghari Pasca Pengobatan Massal Tahap III telah dilaksanakan. Penelitian bertujuan untuk mengetahui prevalensi filariasis, mengetahui spesies cacing mikrofilaria, periodisitas mikrofilaria dan pemeriksaan

Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration

DEFF Research Database (Denmark)

Chu, Brian K.; Deming, Michael; Biritwum, Nana-Kwadwo

2013-01-01

Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached...

Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal Tanzania.

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Parker, Melissa; Allen, Tim

2013-07-01

This article documents understandings and responses to mass drug administration (MDA) for the treatment and prevention of lymphatic filariasis among adults and children in northern coastal Tanzania from 2004 to 2011. Assessment of village-level distribution registers, combined with self-reported drug uptake surveys of adults, participant observation and interviews, revealed that at study sites in Pangani and Muheza districts the uptake of drugs was persistently low. The majority of people living at these highly endemic locations either did not receive or actively rejected free treatment. A combination of social, economic and political reasons explain the low uptake of drugs. These include a fear of treatment (attributable, in part, to a lack of trust in international aid and a questioning of the motives behind the distribution); divergence between biomedical and local understandings of lymphatic filariasis; and limited and ineffective communication about the rationale for mass treatment. Other contributory factors are the reliance upon volunteers for distribution within villages and, in some locations, strained relationships between different groups of people within villages as well as between local leaders and government officials. The article also highlights a disjuncture between self-reported uptake of drugs by adults at a village level and the higher uptake of drugs recorded in official reports. The latter informs claims that elimination will be a possibility by 2020. This gives voice to a broader problem: there is considerable pressure for those implementing MDA to report positive results. The very real challenges of making MDA work are pushed to one side - adding to a rhetoric of success at the expense of engaging with local realities. It is vital to address the kind of issues raised in this article if current attempts to eliminate lymphatic filariasis in mainland coastal Tanzania are to achieve their goal.

Neglected Tropical Diseases: Treatment of Dermatological Manifestation of Filariasis with Combination Regimen of Albendazole, Ivermectin, and Loratadine: A Case Report from a Suburban Community in Nigeria

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Osede Ignis Iribhogbe

2017-06-01

Full Text Available Threadlike filarial nematodes have been identified as the causative agent of filariasis. Cutaneous filariasis is caused primarily by Loa loa, Onchocerca volvulus, and Mansonella streptocerca. These parasites occupy the subcutaneous layer of the skin. However, other filarial parasites are usually associated with varying degrees of dermatological manifestations. In the present discourse, two cases of cutaneous filariasis were diagnosed in two female patients (21 and 40 years old, respectively in Remitch Clinic and Maternity located in a nonriverine community in Ekpoma, Edo State, Nigeria. In this report, patients with body mass index (BMI of 18.97 and 23.45 kg/m2, respectively, presented on two different occasions at least 6 months apart with hyperpigmented skin lesions in the upper and lower limbs, respectively. There was associated intense pruritus with no evidence of lymphadenopathy and lymphoedema. Following laboratory confirmation of filariasis, the patients were placed on a single oral dose combination of albendazole (400 mg + ivermectin (200 mcg/kg, while oral doses of loratadine 10 mg were administered daily for 5 days. Patients were carefully followed up for 6 weeks during which recession of the lesion and untoward reactions were monitored. It was observed that within 6 weeks of treatment, there was a dramatic recession of skin lesion. Adverse effect reported from use of the combination was mild. This case report revealed that cutaneous filariasis is not an uncommon presentation of filariasis infestation in Nigeria. The report also validates the safety and efficacy of the combination in the management of cutaneous manifestation of the disease.

T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis

NARCIS (Netherlands)

Yazdanbakhsh, M.; Paxton, W. A.; Kruize, Y. C.; Sartono, E.; Kurniawan, A.; van het Wout, A.; Selkirk, M. E.; Partono, F.; Maizels, R. M.

1993-01-01

To establish the relationships among T and B cell responses, active infection, and clinical manifestations in lymphatic filariasis, filarial-specific lymphocyte proliferation, IgG antibody isotypes, and IgE levels were determined in an exposed population: 31 asymptomatic amicrofilaremics, 43

A comprehensive assessment of lymphatic filariasis in Sri Lanka six years after cessation of mass drug administration.

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Ramakrishna U Rao

Full Text Available The Sri Lankan Anti-Filariasis Campaign conducted 5 rounds of mass drug administration (MDA with diethycarbamazine plus albendazole between 2002 and 2006. We now report results of a comprehensive surveillance program that assessed the lymphatic filariasis (LF situation in Sri Lanka 6 years after cessation of MDA.Transmission assessment surveys (TAS were performed per WHO guidelines in primary school children in 11 evaluation units (EUs in all 8 formerly endemic districts. All EUs easily satisfied WHO criteria for stopping MDA. Comprehensive surveillance was performed in 19 Public Health Inspector (PHI areas (subdistrict health administrative units. The surveillance package included cross-sectional community surveys for microfilaremia (Mf and circulating filarial antigenemia (CFA, school surveys for CFA and anti-filarial antibodies, and collection of Culex mosquitoes with gravid traps for detection of filarial DNA (molecular xenomonitoring, MX. Provisional target rates for interruption of LF transmission were community CFA <2%, antibody in school children <2%, and filarial DNA in mosquitoes <0.25%. Community Mf and CFA prevalence rates ranged from 0-0.9% and 0-3.4%, respectively. Infection rates were significantly higher in males and lower in people who denied prior treatment. Antibody rates in school children exceeded 2% in 10 study sites; the area that had the highest community and school CFA rates also had the highest school antibody rate (6.9%. Filarial DNA rates in mosquitoes exceeded 0.25% in 10 PHI areas.Comprehensive surveillance is feasible for some national filariasis elimination programs. Low-level persistence of LF was present in all study sites; several sites failed to meet provisional endpoint criteria for LF elimination, and follow-up testing will be needed in these areas. TAS was not sensitive for detecting low-level persistence of filariasis in Sri Lanka. We recommend use of antibody and MX testing as tools to complement TAS for

Data reporting constraints for the lymphatic filariasis mass drug administration activities in two districts in Ghana: A qualitative study

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Frances Baaba da-Costa Vroom

2015-07-01

Full Text Available Objectives: Timely and accurate health data are important for objective decision making and policy formulation. However, little evidence exists to explain why poor quality routine health data persist. This study examined the constraints to data reporting for the lymphatic filariasis mass drug administration programme in two districts in Ghana. This qualitative study focused on timeliness and accuracy of mass drug administration reports submitted by community health volunteers. Methods: The study is nested within a larger study focusing on the feasibility of mobile phone technology for the lymphatic filariasis programme. Using an exploratory study design, data were obtained through in-depth interviews (n = 7 with programme supervisors and focus group discussions (n = 4 with community health volunteers. Results were analysed using thematic content analysis. Results: Reasons for delays in reporting were attributed to poor numeracy skills among community health volunteers, difficult physical access to communities, high supervisor workload, poor adherence reporting deadlines, difficulty in reaching communities within allocated time and untimely release of programme funds. Poor accuracy of data was mainly attributed to inadequate motivation for community health volunteers and difficulty calculating summaries. Conclusion: This study has shown that there are relevant issues that need to be addressed in order to improve the quality of lymphatic filariasis treatment coverage reports. Some of the factors identified are problems within the health system; others are specific to the community health volunteers and the lymphatic filariasis programme. Steps such as training on data reporting should be intensified for community health volunteers, allowances for community health volunteers should be re-evaluated and other non-monetary incentives should be provided for community health volunteers.

Impact of rapid urbanization on mosquitoes and their disease transmission potential in Accra and Tema, Ghana.

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Chinery, W A

1995-06-01

The total of 75 mosquito species recorded in Accra have declined to 28 species. Contributing factors to this decline and the reduction in prevalence of malaria and bancroftian filariasis in Accra presently include extensive water pollution and a fairly high daily mosquito mortality due to several factors including loss of natural adult resting places, use of mosquito repellents and the probable increase of Anopheles arabiensis population. Presently low yellow fever incidence is due inter alia to loss of its feral vectors and reduced intradomiciliary breeding of Aedes aegypti (L) although more common species like A. gambiae s.l., A. aegypti and C. p. quinquefasciatus could between them transmit many other arboviruses. However because of ready availability of human blood, spill-over of viruses from reservoir hosts to man will be rare. Ipso factor, malaria is the most common mosquito-borne disease with centripetal distribution of prevalence.

A Study of Bancroftian Filariasis on the Islands of Batan and Rapu Rapu, Philippines

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1988-06-01

difficult duefrom which cases of elephantiasis were to the mountainous terrain and absence of reported to have originated (pers. comm. Division of Disease...iis in each village exhibited elephantiasis . The local people attributed the cause to walking were infective with third-stage larvae, and in cool

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

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Kelly L. Johnston

2014-12-01

Full Text Available Lymphatic filariasis and onchocerciasis are debilitating diseases caused by parasitic filarial nematodes infecting around 150 million people throughout the tropics with more than 1.5 billion at risk. As with other neglected tropical diseases, classical drug-discovery and development is lacking and a 50 year programme of macrofilaricidal discovery failed to deliver a drug which can be used as a public health tool. Recently, antibiotic targeting of filarial Wolbachia, an essential bacterial symbiont, has provided a novel drug treatment for filariasis with macrofilaricidal activity, although the current gold-standard, doxycycline, is unsuitable for use in mass drug administration (MDA. The anti-Wolbachia (A·WOL Consortium aims to identify novel anti-Wolbachia drugs, compounds or combinations that are suitable for use in MDA. Development of a Wolbachia cell-based assay has enabled the screening of the approved human drug-pharmacopoeia (∼2600 drugs for a potential repurposing. This screening strategy has revealed that approved drugs from various classes show significant bacterial load reduction equal to or superior to the gold-standard doxycycline, with 69 orally available hits from different drug categories being identified. Based on our defined hit criteria, 15 compounds were then selectively screened in a Litomosoides sigmodontis mouse model, 4 of which were active. These came from the tetracycline, fluoroquinolone and rifamycin classes. This strategy of repurposing approved drugs is a promising development in the goal of finding a novel treatment against filariasis and could also be a strategy applicable for other neglected tropical diseases.

Community members' perceptions of mass drug administration for control of lymphatic filariasis in rural rural and urban Tanzania

DEFF Research Database (Denmark)

Kisoka, William J.; Tersbøl, Britt Pinkowski; Meyrowitsch, Dan Wolf

2016-01-01

Lymphatic filariasis is one of several neglected tropical diseases with severely disabling and stigmatizing manifestations that are referred to as 'neglected diseases of poverty'. It is a mosquito-borne disease found endemically and exclusively in low-income contexts where, concomitantly, general...

Mathematical models and lymphatic filariasis control: monitoring and evaluating interventions.

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Michael, Edwin; Malecela-Lazaro, Mwele N; Maegga, Bertha T A; Fischer, Peter; Kazura, James W

2006-11-01

Monitoring and evaluation are crucially important to the scientific management of any mass parasite control programme. Monitoring enables the effectiveness of implemented actions to be assessed and necessary adaptations to be identified; it also determines when management objectives are achieved. Parasite transmission models can provide a scientific template for informing the optimal design of such monitoring programmes. Here, we illustrate the usefulness of using a model-based approach for monitoring and evaluating anti-parasite interventions and discuss issues that need addressing. We focus on the use of such an approach for the control and/or elimination of the vector-borne parasitic disease, lymphatic filariasis.

Immunization of Mastomys coucha with Brugia malayi recombinant trehalose-6-phosphate phosphatase results in significant protection against homologous challenge infection.

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Susheela Kushwaha

Full Text Available Development of a vaccine to prevent or reduce parasite development in lymphatic filariasis would be a complementary approach to existing chemotherapeutic tools. Trehalose-6-phosphate phosphatase of Brugia malayi (Bm-TPP represents an attractive vaccine target due to its absence in mammals, prevalence in the major life stages of the parasite and immunoreactivity with human bancroftian antibodies, especially from endemic normal subjects. We have recently reported on the cloning, expression, purification and biochemical characterization of this vital enzyme of B. malayi. In the present study, immunoprophylactic evaluation of Bm-TPP was carried out against B. malayi larval challenge in a susceptible host Mastomys coucha and the protective ability of the recombinant protein was evaluated by observing the adverse effects on microfilarial density and adult worm establishment. Immunization caused 78.4% decrease in microfilaremia and 71.04% reduction in the adult worm establishment along with sterilization of 70.06% of the recovered live females. The recombinant protein elicited a mixed Th1/Th2 type of protective immune response as evidenced by the generation of both pro- and anti-inflammatory cytokines IL-2, IFN-γ, TNF-α, IL-4 and an increased production of antibody isotypes IgG1, IgG2a, IgG2b and IgA. Thus immunization with Bm-TPP conferred considerable protection against B. malayi establishment by engendering a long-lasting effective immune response and therefore emerges as a potential vaccine candidate against lymphatic filariasis (LF.

Mathematical models for lymphatic filariasis transmission and control: Challenges and prospects

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Kaliannagounder Krishnamoorthy

2008-02-01

Full Text Available Abstract Background Mathematical models developed for describing the dynamics of transmission, infection, disease and control of lymphatic filariasis (LF gained momentum following the 1997 World Health Assembly resolution and the launching of the Global Programme to Eliminate Lymphatic Filariasis (GPELF in 2000. Model applications could provide valuable inputs for making decisions while implementing large scale programmes. However these models need to be evaluated at different epidemiological settings for optimization and fine-tuning with new knowledge and understanding on infection/disease dynamics. Discussion EPIFIL and LYMFASIM are the two mathematical simulation models currently available for lymphatic filariasis transmission and control. Both models have been used for prediction and evaluation of control programmes under research settings. Their widespread application in evaluating large-scale elimination programmes warrants validation of assumptions governing the dynamics of infection and disease in different epidemiological settings. Furthermore, the predictive power of the models for decision support can be enhanced by generating knowledge on some important issues that pose challenges and incorporating such knowledge into the models. We highlight factors related to the efficacy of the drugs of choice, their mode of action, and the possibility that drug resistance may develop; the role of vector-parasite combinations; the magnitude of transmission thresholds; host-parasite interactions and their effects on the dynamics of infection and immunity; parasite biology, and progression to LF-associated disease. Summary The two mathematical models developed offer potential decision making tools for transmission and control of LF. In view of the goals of the GPELF, the predictive power of these models needs to be enhanced for their wide-spread application in large scale programmes. Assimilation and translation of new information into the models is

Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis

NARCIS (Netherlands)

Kurniawan, A.; Yazdanbakhsh, M.; van Ree, R.; Aalberse, R.; Selkirk, M. E.; Partono, F.; Maizels, R. M.

1993-01-01

A population of 164 adult individuals resident in an area endemic for Brugia malayi lymphatic filariasis has been studied for humoral immune responses to filarial parasites. Antibody levels to Ag extracted from adult worms were determined for each of the IgG subclasses, for IgM and for IgE. The

Coverage and compliance MDA programme for lymphatic filariasis in Bidar district, Karnataka, India

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Dharukaswami. Mallayya. Koradhanyamath

2012-08-01

Full Text Available Objective: To describe the socio demographic characteristics of beneficiaries of the Mass Drug Administration (MDA programme, to assess the coverage, compliance and causes for noncompliance towards MDA in the district, to assess the awareness regarding elephantiasis among beneficiaries and to assess the knowledge of drug distributors towards the filariasis and MDA programme. Methods: This cross sectional study was conducted in 3 rural and 1 urban clusters in Bidar district for the period of 1 week. 50 houses were selected in each cluster by systematic random sampling method and data was collected in a structured proforma by interview technique. Results: Majority of beneficiaries were at the age group of 15-60 years (72.3% and male (53%. The overall coverage of MDA in Bidar district was 62.3%. Compliance among those who had received the tablets was 60.4%. Coverage and compliance was more in rural areas compared to urban. The most common reason quoted for not consuming drugs was fear of adverse effects (72.2% The incidence of adverse events was 0.2%. Even though 75% of them were aware of the disease elephantiasis, only 45.4% had knowledge regarding MDA programme. The knowledge of drug distributors towards MDA and filariasis was found to be adequate. Conclusions: Coverage and compliance towards MDA in Bidar district was poor. The coverage and compliance in rural areas was higher compared to the urban areas.

Asupan seng dan status seng yang rendah sebagai faktor risiko kejadian infeksi filariasis (studi kasus di kota pekalongan

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Dewi Nugraheni Restu Mastuti

2016-12-01

Full Text Available Background: Microfilariae infections in the human body does not always cause symptoms. filaria infected humans would induce a Th2 response by increasing the production of IL-4, IL-5, IL-13 and increased serum levels of IgE. Zinc deficiency is directly related to the regulation of immune response that is reduced due to decline in lymphopoesis as well as the effect on the immune response and the production of antibodies in people with normal nutritional status.Objective: This research is analytic survey with case control approach. Samples were selected with a total engineering sample of 42 people infected with filariasis of the samples taken by Comparing the number of 1 : 1. The subjects of the study were obtained when only 30 cases and 30 controls chosen. Zinc intake assessment is done by using a food frequency ( FFQ and food recall 3 x 24 hours later treated with Nutrisoft program. Assessment of serum zinc performed with venous blood sampling as much as 3 cc made 1 time. Statistical analysis was performed with chi square test.Results: Group infected and not infected with filariasis less zinc intake was 54.7 % and 45.3 % , zinc status is lacking in both infected and uninfected group was 50.0 % and 50.0 %. Thus intake of zinc and zinc status were less does not constitute a risk factor in the study group ( zinc intake : Value- p = 0.103 ; OR = 7.250 with a value 95 % CI = 0.815 to 64.45 and zinc status : p - value = 1.000 ; OR = 1,000 with a value 95 % CI = 0.131 to 7.605 .Conclusion: The intake of zinc and low zinc status is not a risk factor incidence of filariasis infection in areas of research.

Lymphatic filarial species differentiation using evolutionarily modified tandem repeats: generation of new genetic markers.

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Sakthidevi, Moorthy; Murugan, Vadivel; Hoti, Sugeerappa Laxmanappa; Kaliraj, Perumal

2010-05-01

Polymerase chain reaction based methods are promising tools for the monitoring and evaluation of the Global Program for the Elimination of Lymphatic Filariasis. The currently available PCR methods do not differentiate the DNA of Wuchereria bancrofti or Brugia malayi by a single PCR and hence are cumbersome. Therefore, we designed a single step PCR strategy for differentiating Bancroftian infection from Brugian infection based on a newly identified gene from the W. bancrofti genome, abundant larval transcript-2 (alt-2), which is abundantly expressed. The difference in PCR product sizes generated from the presence or absence of evolutionarily altered tandem repeats in alt-2 intron-3 differentiated W. bancrofti from B. malayi. The analysis was performed on the genomic DNA of microfilariae from a number of patient blood samples or microfilariae positive slides from different Indian geographical regions. The assay gave consistent results, differentiating the two filarial parasite species accurately. This alt-2 intron-3 based PCR assay can be a potential tool for the diagnosis and differentiation of co-infections by lymphatic filarial parasites. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Maternal Infection Is a Risk Factor for Early Childhood Infection in Filariasis.

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Madhusmita Bal

Full Text Available Global Program to Eliminate Lymphatic Filariasis (GPELF launched by WHO aims to eliminate the disease by 2020. To achieve the goal annual mass drug administration (MDA with diethylcarbamazine (DEC plus albendazole (ABZ has been introduced in all endemic countries. The current policy however excludes pregnant mothers and children below two years of age from MDA. Since pregnancy and early childhood are critical periods in determining the disease outcome in older age, the present study was undertaken to find out the influence of maternal filarial infection at the time of pregnancy on the susceptibility outcome of children born in a community after implementation of MDA for the first time.The participants in this cohort consists of pregnant mothers and their subsequently born children living in eight adjacent villages endemic for filarial infections, in Khurda District, Odisha, India, where MDA has reduced microfilariae (Mf rate from 12% to 0.34%. Infection status of mother and their children were assessed by detection of Mf as well as circulating filarial antigen (CFA assay. The present study reveals a high rate of acquiring filarial infection by the children born to infected mother than uninfected mothers even though Mf rate has come down to < 1% after implementation of ten rounds of MDA.To attain the target of eliminating lymphatic filariasis the current MDA programme should give emphasis on covering the women of child bearing age. Our study recommends incorporating supervised MDA to Adolescent Reproductive and Sexual Health Programme (ARSH to make the adolescent girls free from infection by the time of pregnancy so as to achieve the goal.

Applicability of the Filter Paper Technique for Detection of AntifilarialIgG4 Antibodies Using the Bm14 Filariasis CELISA

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Hayley M. Joseph

2010-01-01

Full Text Available Demonstration of successful elimination of lymphatic filariasis (LF in endemic countries requires sensitive diagnostics for accurate definitions of endpoints and future surveillance. There has been interest in complementing available diagnostics with antibody serology testing in children, since negative serology would correspond with cessation of LF transmission. The Filariasis CELISA detects antifilarial IgG4 and has favourable results with serum samples but field application requires an easier sampling method. Ninety-four paired plasma and filter paper samples were assayed with promising results. The filter paper method resulted in a sensitivity of 92% and a specificity of 77% when compared to the paired plasma. One hundred and one filter paper samples were assessed for storage effects. Following 10-month storage at −20∘C there was a significant reduction in reactivity (<.001. Overall the results indicated that filter paper sampling would be a favourable sensitive and specific alternative for blood collection in surveys.

Surveillance efforts after mass drug administration to validate elimination of lymphatic filariasis as a public health problem in Vanuatu.

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Taleo, Fasihah; Taleo, George; Graves, Patricia M; Wood, Peter; Kim, Sung Hye; Ozaki, Masayo; Joseph, Hayley; Chu, Brian; Pavluck, Alex; Yajima, Aya; Melrose, Wayne; Ichimori, Kazuyo; Capuano, Corinne

2017-01-01

Vanuatu was formerly highly endemic for lymphatic filariasis (LF), caused by Wuchereria bancrofti and transmitted by Anopheles mosquitoes. After a baseline survey showing 4.8% antigen prevalence in 1998, the country conducted nationwide (in one implementation unit) annual mass drug administration (MDA) with albendazole and diethylcarbamazine citrate from 2000 to 2004 and achieved prevalence of 0.2% by 2006 in a representative nationwide cluster survey among all age groups. Post MDA surveillance was conducted from 2006 to 2012. After MDA, the country was divided for surveillance into three evaluation units (EUs) formed by grouping provinces according to baseline prevalence: EU1: Torba, Sanma and Malampa; EU2: Penama; EU3: Shefa and Tafea. The study compiled all past data and information on surveys in Vanuatu from the country programme. This paper reviews the surveillance activities done after stopping MDA to validate the interruption of transmission and elimination of LF as a public health problem. Post-MDA surveillance consisting of at least three transmission assessment surveys (TAS) in each of the three EUs was conducted between 2006 and 2012. Sentinel and spot check surveys identified a few villages with persistent high prevalence; all antigen positive cases in these sites were treated and additional targeted MDA conducted for 3 years in 13 villages in one area of concern. All three EUs passed all TAS in 2007, 2010 and 2012 respectively, with no positives found except in EU2 (Penama province) in 2012 when 2 children tested positive for circulating filariasis antigen. Assessment of the burden of chronic filariasis morbidity found 95 cases in 2003 and 32 remaining cases in 2007, all aged over 60 years. Vanuatu has achieved validation of elimination of LF as a public health problem. Post-validation surveillance is still recommended especially in formerly highly endemic areas.

Socio-cultural aspects of lymphatic filariasis and the role of communities in its control in Ghana

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Gyapong, Margaret

2000-01-01

Lymphatic Filariasis (LF) is one of the worlds most debilitating and disfiguring tropical diseases. The World Health Organization estimates that there are about one billion people at risk in about 80 countries worldwide. It is the world’s second leading cause of permanent long-term disability and its prevalence continues to increase. The World Bank development report indicates that the global burden for the disease was estimated at 850,000 DALY’s lost which represents only 0.23...

How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector?

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Christopher M Stone

2014-12-01

Full Text Available The opportunity to integrate vector management across multiple vector-borne diseases is particularly plausible for malaria and lymphatic filariasis (LF control where both diseases are transmitted by the same vector. To date most examples of integrated control targeting these diseases have been unanticipated consequences of malaria vector control, rather than planned strategies that aim to maximize the efficacy and take the complex ecological and biological interactions between the two diseases into account.We developed a general model of malaria and LF transmission and derived expressions for the basic reproductive number (R0 for each disease. Transmission of both diseases was most sensitive to vector mortality and biting rate. Simulating different levels of coverage of long lasting-insecticidal nets (LLINs and larval control confirms the effectiveness of these interventions for the control of both diseases. When LF was maintained near the critical density of mosquitoes, minor levels of vector control (8% coverage of LLINs or treatment of 20% of larval sites were sufficient to eliminate the disease. Malaria had a far greater R0 and required a 90% population coverage of LLINs in order to eliminate it. When the mosquito density was doubled, 36% and 58% coverage of LLINs and larval control, respectively, were required for LF elimination; and malaria elimination was possible with a combined coverage of 78% of LLINs and larval control.Despite the low level of vector control required to eliminate LF, simulations suggest that prevalence of LF will decrease at a slower rate than malaria, even at high levels of coverage. If representative of field situations, integrated management should take into account not only how malaria control can facilitate filariasis elimination, but strike a balance between the high levels of coverage of (multiple interventions required for malaria with the long duration predicted to be required for filariasis elimination.

How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector?

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Stone, Christopher M; Lindsay, Steve W; Chitnis, Nakul

2014-12-01

The opportunity to integrate vector management across multiple vector-borne diseases is particularly plausible for malaria and lymphatic filariasis (LF) control where both diseases are transmitted by the same vector. To date most examples of integrated control targeting these diseases have been unanticipated consequences of malaria vector control, rather than planned strategies that aim to maximize the efficacy and take the complex ecological and biological interactions between the two diseases into account. We developed a general model of malaria and LF transmission and derived expressions for the basic reproductive number (R0) for each disease. Transmission of both diseases was most sensitive to vector mortality and biting rate. Simulating different levels of coverage of long lasting-insecticidal nets (LLINs) and larval control confirms the effectiveness of these interventions for the control of both diseases. When LF was maintained near the critical density of mosquitoes, minor levels of vector control (8% coverage of LLINs or treatment of 20% of larval sites) were sufficient to eliminate the disease. Malaria had a far greater R0 and required a 90% population coverage of LLINs in order to eliminate it. When the mosquito density was doubled, 36% and 58% coverage of LLINs and larval control, respectively, were required for LF elimination; and malaria elimination was possible with a combined coverage of 78% of LLINs and larval control. Despite the low level of vector control required to eliminate LF, simulations suggest that prevalence of LF will decrease at a slower rate than malaria, even at high levels of coverage. If representative of field situations, integrated management should take into account not only how malaria control can facilitate filariasis elimination, but strike a balance between the high levels of coverage of (multiple) interventions required for malaria with the long duration predicted to be required for filariasis elimination.

Lymphatic filariasis in Peninsular Malaysia: a cross-sectional survey of the knowledge, attitudes, and practices of residents.

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Al-Abd, Nazeh M; Nor, Zurainee Mohamed; Ahmed, Abdulhamid; Al-Adhroey, Abdulelah H; Mansor, Marzida; Kassim, Mustafa

2014-11-27

Lymphatic filariasis (LF) is a major cause of permanent disability in many tropical and sub-tropical countries of the world. Malaysia is one of the countries in which LF is an endemic disease. Five rounds of the mass drug administration (MDA) program have been conducted in Malaysia as part of the Global Program to Eliminate Lymphatic Filariasis (GPELF) by year 2020. This study investigated the level of awareness of LF and the MDA program in a population living in an endemic area of the country. A descriptive cross-sectional survey that involved 230 respondents (≥15 years old) living in the LF endemic communities of Terengganu state in Peninsular Malaysia was performed. Demographic, socioeconomic, and knowledge, attitudes and practices (KAP) data of the respondents were obtained using pre-tested questionnaires and were analyzed using SPSS software version 13.0. More than 80% of the respondents were aware of LF and the common symptoms of the disease. Moreover, about 70% of the respondents that were aware of LF indicated that it is a problematic disease. Approximately 77% of the respondents indicated that filariasis is transmitted by mosquitoes. Two-thirds of respondents preferred hospital treatment for illness; however, only 12% had participated and/or received treatment for LF during an MDA program. Only 35% of the respondents that participated in this research were aware of the MDA program that had taken place in the area. None of the respondents had knowledge of the drug used in the treatment of LF. The findings from this research indicated that there was no significant association between LF awareness and with gender, age group, educational status, occupation, or socio-economic status of the respondents (P >0.05). A good proportion of the respondents are aware of LF, its mode of transmission and symptoms, however they demonstrated a poor knowledge of MDA which took place in the study area. For greater understanding of LF in the Malaysian population, there is a

Diagnosis of brugian filariasis by loop-mediated isothermal amplification.

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Catherine B Poole

Full Text Available In this study we developed and evaluated a Brugia Hha I repeat loop-mediated isothermal amplification (LAMP assay for the rapid detection of Brugia genomic DNA. Amplification was detected using turbidity or fluorescence as readouts. Reactions generated a turbidity threshold value or a clear visual positive within 30 minutes using purified genomic DNA equivalent to one microfilaria. Similar results were obtained using DNA isolated from blood samples containing B. malayi microfilariae. Amplification was specific to B. malayi and B. timori, as no turbidity was observed using DNA from the related filarial parasites Wuchereria bancrofti, Onchocerca volvulus or Dirofilaria immitis, or from human or mosquito. Furthermore, the assay was most robust using a new strand-displacing DNA polymerase termed Bst 2.0 compared to wild-type Bst DNA polymerase, large fragment. The results indicate that the Brugia Hha I repeat LAMP assay is rapid, sensitive and Brugia-specific with the potential to be developed further as a field tool for diagnosis and mapping of brugian filariasis.

Impact of Education Campaign on Community-Based Vector Control in Hastening the Process of Elimination of Lymphatic Filariasis in Tamil Nadu, South India

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Nandha, B.; Krishnamoorthy, K.

2012-01-01

Globally mosquito-borne lymphatic filariasis (LF) is targeted for elimination by 2020. Towards this goal, the scope of community-based vector control as a supplementary strategy to mass drug administration (MDA) was assessed through an intensive education campaign and evaluated using pre- and post-educational surveys in an intervention and…

Generation and selection of naïve Fab library for parasitic antigen: Anti-BmSXP antibodies for lymphatic filariasis.

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Omar, Noorsharmimi; Hamidon, Nurul Hamizah; Yunus, Muhammad Hafiznur; Noordin, Rahmah; Choong, Yee Siew; Lim, Theam Soon

2018-05-01

Phage display has been applied successfully as a tool for the generation of monoclonal antibodies (mAbs). Naive antibody libraries are unique as they are able to overcome several limitations associated with conventional mAb generation methods like the hybridoma technology. Here, we performed an in vitro selection and generation of Fab antibodies against Brugia malayi SXP protein (BmSXP), a recombinant antigen for the detection of lymphatic filariasis. We developed a naïve multi ethnic Fab antibody library with an estimated diversity of 2.99 × 10 9 . The antibody library was used to screen for mAbs against BmSXP recombinant antigen. Soluble monoclonal Fab antibodies against BmSXP were successfully isolated from the naïve library. The Fab antibodies obtained were expressed and analyzed to show its binding capability. The diversity obtained from a pool of donors from various ethnic groups allowed for a diverse antibody library to be generated. The mAbs obtained were also functional in soluble form, which makes it useful for further downstream applications. We believe that the Fab mAbs are valuable for further studies and could also contribute to improvements in the diagnosis of filariasis. © 2017 International Union of Biochemistry and Molecular Biology, Inc.

Lymphatic Filariasis Increases Tissue Compressibility and Extracellular Fluid in Lower Limbs of Asymptomatic Young People in Central Myanmar

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Janet Douglass

2017-09-01

Full Text Available When normal lymphatic function is hampered, imperceptible subcutaneous edema can develop and progress to overt lymphedema. Low-cost reliable devices for objective assessment of lymphedema are well accepted in clinical practice and research on breast-cancer related lymphedema but are untested in populations with lymphatic filariasis (LF. This is a cross-sectional analysis of baseline data in a longitudinal study on asymptomatic, LF antigen-positive and -negative young people in Myanmar. Rapid field screening was used to identify antigen-positive cases and a group of antigen-negative controls of similar age and gender were invited to continue in the study. Tissue compressibility was assessed with three tissue tonometers, and free fluids were assessed using bio-impedance spectroscopy (BIS. Infection status was confirmed by Og4C3 antigen assay. At baseline (n = 98, antigen-positive cases had clinically relevant increases in tissue compressibility at the calf using a digital Indurometer (11.1%, p = 0.021, and in whole-leg free fluid using BIS (9.2%, p = 0.053. Regression analysis for moderating factors (age, gender, hydration reinforced the between-infection group differences. Results demonstrate that sub-clinical changes associated with infection can be detected in asymptomatic cases. Further exploration of these low-cost devices in clinical and research settings on filariasis-related lymphedema are warranted.

Mapping and modelling the impact of mass drug adminstration on filariasis prevalence in Myanmar.

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Aye, Ni Ni; Lin, Zaw; Lon, Khin Nan; Linn, Nay Yi Yi; Nwe, Thet Wai; Mon, Khin Mon; Ramaiah, Kapa; Betts, Hannah; Kelly-Hope, Louise A

2018-05-31

Lymphatic filariasis (LF) is endemic in Myanmar and targeted for elimination. To highlight the National Programme to Eliminate Lymphatic Filariasis (NPELF) progress between 2000 and 2014, this paper describes the geographical distribution of LF, the scale-up and impact of mass drug administration (MDA) implementation, and the first evidence of the decline in transmission in five districts. The LF distribution was determined by mapping historical and baseline prevalence data collected by NPELF. Data on the MDA implementation, reported coverage rates and sentinel site surveillance were summarized. A statistical model was developed from the available prevalence data to predict prevalence at township level by year of measurement. Transmission assessment survey (TAS) methods, measuring antigenemia (Ag) prevalence in children, were used to determine whether prevalence was below a level where recrudescence is unlikely to occur. The highest baseline LF prevalence was found in the Central Valley region. The MDA implementation activities scaled up to cover 45 districts, representing the majority of the endemic population, with drug coverage rates ranging from 60.0% to 98.5%. Challenges related to drug supply and local conflict were reported, and interrupted MDA in some districts. Overall, significant reductions in LF prevalence were found, especially after the first 2 to 3 rounds of MDA, which was supported by the corresponding model. The TAS activities in five districts found only two Ag positive children, resulting in all districts passing the critical threshold. Overall, the Myanmar NPELF has made positive steps forward in the elimination of LF despite several challenges, however, it needs to maintain momentum, drawing on international stakeholder support, to aim towards the national and global goals of elimination.

Aplicabilidad del test rápido y de las pruebas serológicas en el control del progreso de la oncocercosis y la filariasis linfática en la región continental de Guinea Ecuatorial

OpenAIRE

García Fernández, María Belén

2018-01-01

[EN] La oncocercosis y la filariasis linfática están catalogadas por la Organización Mundial de la Salud (OMS) como Enfermedades Tropicales Desatendidas (ETD) puesto que están asociadas a entornos de pobreza y causan discapacidad y deficiencias para toda la vida. Estas enfermedades son endémicas en Guinea Ecuatorial. En 1987 el Programa Nacional de Oncocercosis y otras Filariasis del Ministerio de Sanidad inició las actividades de control. A lo largo de estos años se realizó tratamiento...

How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector?

OpenAIRE

Stone, C.; Lindsay, S.W.; Chitnis, N.

2014-01-01

Background: The opportunity to integrate vector management across multiple vector-borne diseases is particularly plausible for malaria and lymphatic filariasis (LF) control where both diseases are transmitted by the same vector. To date most examples of integrated control targeting these diseases have been unanticipated consequences of malaria vector control, rather than planned strategies that aim to maximize the efficacy and take the complex ecological and biological interactions between th...

Gambaran Igg4 dan Ige terhadap Protein Mikrofilaria pada Sera Penduduk Endemis Filariasis di Kecamatan Pasir Penyu, Riau

OpenAIRE

SU, Basundari; Kurniawan, Liliana; A., Soeroto; Marleta, Rita; Yasin, M

1993-01-01

Western blot test to detect specific IgG4 and IgE was performed to 12 microfilaraemic and 13 amicrofilaraemic individuals from malayan filariasis endemic area, Pasir Penyu, Riau. No differences in binding patterns of IgG4 and IgE antibodies to microfUarial protein components was shown. There was a parallel protein components recognition by IgG4 and IgE of molecular weight ranging from 158 kd to 14 kd. Protein component of 125 kd was only recognized by IgG4 and of 112 kd only by IgE. These fin...

An evaluation of coverage and compliance of mass drug administration 2006 for elimination of lymphatic filariasis in endemic areas of Gujarat

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Kumar Pradeep

2008-01-01

Full Text Available Background: Mass drug administration (MDA means once-in-a-year administration of diethyl carbamazine (DEC tablet to all people (excluding children under 2 years, pregnant women and severely ill persons in identified endemic areas. It aims at cessation of transmission of lymphatic filariasis. Objective: What has been the coverage and compliance of MDA in Gujarat during the campaign in December 2006? Study Design: Cross-sectional population based house-to-house visit. Setting: Urban and rural areas in Gujarat identified as endemic for filariasis where MDA 2006 was undertaken. Study Variables: Exploratory - Rural and urban districts; Outcome - coverage, compliance, actual coverage, side effects. Analysis: Percentage and proportions. Results: Twenty-six clusters, each comprising 32 households from six endemic districts, yielded an eligible population of 4164. The coverage rate was 85.2% with variation across different areas. The compliance with drug ingestion was 89% with a gap of 11% to be targeted by intensive IEC. The effective coverage (75.8% was much below the target (85%. Side effects of DEC were minimum, transient and drug-specific. Overall coverage was marginally better in rural areas. The causes of poor coverage and compliance have been discussed and relevant suggestions have been made.

Filarial-specific antibody response in East African bancroftian filariasis: effects of host infection, clinical disease, and filarial endemicity

DEFF Research Database (Denmark)

Jaoko, Walter G; Simonsen, Paul E; Meyrowitsch, Dan W

2006-01-01

bancrofti endemicity. In the high endemicity community, intensities of the measured antibodies were significantly associated with infection status. IgG1, IgG2, and IgE were negatively associated with microfilaria (MF) status, IgG3 was negatively associated with circulating filarial antigen (CFA) status......, and IgG4 was positively associated with CFA status. None of the associations were significantly influenced by chronic lymphatic disease status. In contrast, IgG1, IgG2, and IgG4 responses were less vigorous in the low endemicity community and, except for IgG4, did not show any significant associations...... with MF or CFA status. The IgG3 responses were considerably more vigorous in the low endemicity community than in the high endemicity one. Only IgG4 responses exhibited a rather similar pattern in the two communities, being significantly positively associated with CFA status in both communities. The IgG4...

Coverage of, and compliance with, mass drug administration under the programme to eliminate lymphatic filariasis in India: a systematic review.

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Babu, Bontha V; Babu, Gopalan R

2014-09-01

India's mass drug administration (MDA) programme to eliminate lymphatic filariasis (PELF) covers all 250 endemic districts, but compliance with treatment is not adequate for the programme to succeed in eradicating this neglected tropical disease. The objective of our study was to systematically review published studies on the coverage of and compliance with MDA under the PELF in India. We searched several databases-PubMed/Medline, Google Scholar, CINAHL/EBSCO, Web of Knowledge (including Web of Science) and OVID-and by applying selection criteria identified a total of 36 papers to include in the review. Overall MDA coverage rates varied between 48.8% and 98.8%, while compliance rates ranged from 20.8% to 93.7%. The coverage-compliance gap is large in many MDA programmes. The effective level of compliance, ≥65%, was reported in only 10 of a total of 31 MDAs (5 of 20 MDAs in rural areas and 2 of 12 MDAs in urban areas). The review has identified a gap between coverage and compliance, and potentially correctable causes of this gap. These causes need to be addressed if the Indian programme is to advance towards elimination of lymphatic filariasis. © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in Republic of the Congo.

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Pion, Sébastien D S; Chesnais, Cédric B; Weil, Gary J; Fischer, Peter U; Missamou, François; Boussinesq, Michel

2017-07-01

The standard treatment strategy of mass drug administration with ivermectin plus albendazole for lymphatic filariasis cannot be applied in central Africa, because of the risk of serious adverse events in people with high Loa loa microfilaraemia. Thus, alternative strategies are needed. We investigated one such alternative strategy for mass drug administration for elimination of lymphatic filariasis and soil-transmitted helminth infections in Republic of the Congo. In 2012, we started a 3 year community trial of biannual mass administration of albendazole in a village in Republic of the Congo. All volunteering inhabitants aged 2 years or older were offered albendazole (400 mg) every 6 months. Infection with Wuchereria bancrofti was diagnosed with a rapid card immunochromatographic test for antigenaemia. People with antigenaemia were tested for microfilaraemia by night blood smears. Individuals were also tested for soil-transmitted helminth infections (ie, hookworm, Ascaris lumbricoides, Trichuris trichiura) with the Kato-Katz method. Assessment surveys were done at 12, 24, and 36 months. The main outcome measure was change in infection rates from baseline to year 3. Therapeutic coverage was more than 80% in all six rounds of mass administration of albendazole. Between 2012 and 2015, W bancrofti antigenaemia and microfilaraemia rates in the community fell significantly, from 17·3% (95% CI 14·7-20·0) to 4·7% (3·3-6·6; palbendazole to eliminate lymphatic filariasis in areas where loiasis is co-endemic and ivermectin cannot be safely mass administered. Bill & Melinda Gates Foundation. Copyright © 2017 Elsevier Ltd. All rights reserved.

No Evidence for Lymphatic Filariasis Transmission in Big Cities Affected by Conflict Related Rural-Urban Migration in Sierra Leone and Liberia

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de Souza, Dziedzom K.; Sesay, Santigie; Moore, Marnijina G.; Ansumana, Rashid; Narh, Charles A.; Kollie, Karsor; Rebollo, Maria P.; Koudou, Benjamin G.; Koroma, Joseph B.; Bolay, Fatorma K.; Boakye, Daniel A.; Bockarie, Moses J.

2014-01-01

Background In West Africa, the principal vectors of lymphatic filariasis (LF) are Anopheles species with Culex species playing only a minor role in transmission, if any. Being a predominantly rural disease, the question remains whether conflict-related migration of rural populations into urban areas would be sufficient for active transmission of the parasite. Methodology/Principal Findings We examined LF transmission in urban areas in post-conflict Sierra Leone and Liberia that experienced significant rural-urban migration. Mosquitoes from Freetown and Monrovia, were analyzed for infection with Wuchereria bancrofti. We also undertook a transmission assessment survey (TAS) in Bo and Pujehun districts in Sierra Leone. The majority of the mosquitoes collected were Culex species, while Anopheles species were present in low numbers. The mosquitoes were analyzed in pools, with a maximum of 20 mosquitoes per pool. In both countries, a total of 1731 An. gambiae and 14342 Culex were analyzed for W. bancrofti, using the PCR. Two pools of Culex mosquitoes and 1 pool of An. gambiae were found infected from one community in Freetown. Pool screening analysis indicated a maximum likelihood of infection of 0.004 (95% CI of 0.00012–0.021) and 0.015 (95% CI of 0.0018–0.052) for the An. gambiae and Culex respectively. The results indicate that An. gambiae is present in low numbers, with a microfilaria prevalence breaking threshold value not sufficient to maintain transmission. The results of the TAS in Bo and Pujehun also indicated an antigen prevalence of 0.19% and 0.67% in children, respectively. This is well below the recommended 2% level for stopping MDA in Anopheles transmission areas, according to WHO guidelines. Conclusions We found no evidence for active transmission of LF in cities, where internally displaced persons from rural areas lived for many years during the more than 10 years conflict in Sierra Leone and Liberia. PMID:24516686

Investing in justice: ethics, evidence, and the eradication investment cases for lymphatic filariasis and onchocerciasis.

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Bailey, Theodore C; Merritt, Maria W; Tediosi, Fabrizio

2015-04-01

It has been suggested that initiatives to eradicate specific communicable diseases need to be informed by eradication investment cases to assess the feasibility, costs, and consequences of eradication compared with elimination or control. A methodological challenge of eradication investment cases is how to account for the ethical importance of the benefits, burdens, and distributions thereof that are salient in people's experiences of the diseases and related interventions but are not assessed in traditional approaches to health and economic evaluation. We have offered a method of ethical analysis grounded in theories of social justice. We have described the method and its philosophical rationale and illustrated its use in application to eradication investment cases for lymphatic filariasis and onchocerciasis, 2 neglected tropical diseases that are candidates for eradication.

Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria.

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Abel Eigege

Full Text Available In central Nigeria Anopheles mosquitoes transmit malaria and lymphatic filariasis (LF. The strategy used for interrupting LF transmission in this area is annual mass drug administration (MDA with albendazole and ivermectin, but after 8 years of MDA, entomological evaluations in sentinel villages showed continued low-grade mosquito infection rates of 0.32%. After long-lasting insecticidal net (LLIN distribution by the national malaria program in late 2010, however, we were no longer able to detect infected vectors over a 24-month period. This is evidence that LLINs are synergistic with MDA in interrupting LF transmission.

The effects of size and synthesis methods of gold nanoparticle-conjugated MαHIgG4 for use in an immunochromatographic strip test to detect brugian filariasis

Science.gov (United States)

Rabizah Makhsin, Siti; Razak, Khairunisak Abdul; Noordin, Rahmah; Dyana Zakaria, Nor; Chun, Tan Soo

2012-12-01

This study describes the properties of colloidal gold nanoparticles (AuNPs) with sizes of 20, 30 and 40 nm, which were synthesized using citrate reduction or seeding-growth methods. Likewise, the conjugation of these AuNPs to mouse anti-human IgG4 (MαHIgG4) was evaluated for an immunochromatographic (ICG) strip test to detect brugian filariasis. The morphology of the AuNPs was studied based on the degree of ellipticity (G) of the transmission electron microscopy images. The AuNPs produced using the seeding-growth method showed lower ellipticity (G ≤ 1.11) as compared with the AuNPs synthesized using the citrate reduction method (G ≤ 1.18). Zetasizer analysis showed that the AuNPs that were synthesized using the seeding-growth method were almost monodispersed with a lower polydispersity index (PDI; PDI≤0.079), as compared with the AuNPs synthesized using the citrate reduction method (PDI≤0.177). UV-visible spectroscopic analysis showed a red-shift of the absorbance spectra after the reaction with MαHIgG4, which indicated that the AuNPs were successfully conjugated. The optimum concentration of the BmR1 recombinant antigen that was immobilized on the surface of the ICG strip on the test line was 1.0 mg ml-1. When used with the ICG test strip assay and brugian filariasis serum samples, the conjugated AuNPs-MαHIgG4 synthesized using the seeding-growth method had faster detection times, as compared with the AuNPs synthesized using the citrate reduction method. The 30 nm AuNPs-MαHIgG4, with an optical density of 4 from the seeding-growth method, demonstrated the best performance for labelling ICG strips because it displayed the best sensitivity and the highest specificity when tested with serum samples from brugian filariasis patients and controls.

Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1/Th2 Type Immune Response and Inhibits Larval Development in the Host

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Prashant K. Singh

2014-01-01

Full Text Available Lymphatic filariasis is a major debilitating disease, endemic in 72 countries putting more than 1.39 billion people at risk and 120 million are already infected. Despite the significant progress in chemotherapeutic advancements, there is still need for other measures like development of an effective vaccine or discovery of novel drug targets. In this study, structural and immunological characterization of independent phosphoglycerate mutase of filarial parasite Brugia malayi was carried out. Protein was found to be expressed in all major parasite life stages and as an excretory secretory product of adult parasites. Bm-iPGM also reacted to all the categories of human bancroftian patient’s sera including endemic normals. In vivo immunological behaviour of protein was determined in immunized BALB/c mice followed by prophylactic analysis in BALB/c mice and Mastomys coucha. Immunization with Bm-iPGM led to generation of a mixed Th1/Th2 type immune response offering 58.2% protection against larval challenge in BALB/c and 65–68% protection in M. coucha. In vitro studies confirmed participation of anti-Bm-iPGM antibodies in killing of B. malayi infective larvae and microfilariae through ADCC mechanism. The present findings reveal potential immunoprotective nature of Bm-iPGM advocating its worth as an antifilarial vaccine candidate.

Laboratory and field evaluation of an oviposition trap for Culex quinquefasciatus(Diptera: Culicidae

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Rosângela MR Barbosa

2007-06-01

Full Text Available An ovitrap (BR-OVT based on physical and chemical stimuli for attracting gravid Culex quinquefasciatus (Diptera: Culicidae females was developed and evaluated under laboratory and field conditions. Attractants were assayed using alternative chamber bioassays prior to being used in the BR-OVT oviposition trap. A significant preference of gravid females for sites containing conspecific egg rafts was observed, as a response to the natural oviposition pheromone, as well as for sites treated with the synthetic pheromone erythro-6-acetoxy-5-hexadecanolide. Five- to 20-day old grass infusion was strongly attractive to gravid females for laying eggs. On the other hand, entomopathogenic Bacillus sphaericus (Bs did not influence the choice of an oviposition site when used in combination with grass infusion and can therefore be used as a larvicide in ovitraps. Results from field trials showed that the BR-OVT with grass infusion and with or without Bs works as a preferred oviposition site for Cx. quinquefasciatus. The BR-OVT was more effective for egg collection when placed indoors and comparison with the number of egg rafts laid in cesspits over 40 days indicates that this very simple ovitrap may be a useful tool for monitoring populations of the most important of the vectors of bancroftian filariasis.

Bayesian geostatistical modelling of malaria and lymphatic filariasis infections in Uganda: predictors of risk and geographical patterns of co-endemicity

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Pedersen Erling M

2011-10-01

Full Text Available Abstract Background In Uganda, malaria and lymphatic filariasis (causative agent Wuchereria bancrofti are transmitted by the same vector species of Anopheles mosquitoes, and thus are likely to share common environmental risk factors and overlap in geographical space. In a comprehensive nationwide survey in 2000-2003 the geographical distribution of W. bancrofti was assessed by screening school-aged children for circulating filarial antigens (CFA. Concurrently, blood smears were examined for malaria parasites. In this study, the resultant malariological data are analysed for the first time and the CFA data re-analysed in order to identify risk factors, produce age-stratified prevalence maps for each infection, and to define the geographical patterns of Plasmodium sp. and W. bancrofti co-endemicity. Methods Logistic regression models were fitted separately for Plasmodium sp. and W. bancrofti within a Bayesian framework. Models contained covariates representing individual-level demographic effects, school-level environmental effects and location-based random effects. Several models were fitted assuming different random effects to allow for spatial structuring and to capture potential non-linearity in the malaria- and filariasis-environment relation. Model-based risk predictions at unobserved locations were obtained via Bayesian predictive distributions for the best fitting models. Maps of predicted hyper-endemic malaria and filariasis were furthermore overlaid in order to define areas of co-endemicity. Results Plasmodium sp. parasitaemia was found to be highly endemic in most of Uganda, with an overall population adjusted parasitaemia risk of 47.2% in the highest risk age-sex group (boys 5-9 years. High W. bancrofti prevalence was predicted for a much more confined area in northern Uganda, with an overall population adjusted infection risk of 7.2% in the highest risk age-group (14-19 year olds. Observed overall prevalence of individual co

Evaluation of the recombinant antigens Wb14 and WbT for the capture antibody diagnosis of lymphatic filariasis

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André Filipe Pastor

2018-03-01

Full Text Available BACKGROUND Lymphatic filariasis (LF is a parasitic disease caused mainly by the Wuchereria bancrofti worm and that affects up to 120 million people worldwide. LF is the second cause of chronic global deformity, responsible for 15 million people with lymphedema (elephantiasis and 25 million men with scrotal hydrocele. Its diagnosis is still associated with numerous difficulties, such as the sample collection periods (microfilaria nocturnal periodicity and limited diagnostic kits. OBJECTIVES The aim of this work was to evaluate two recombinant antigens (Wb14 and WbT as part of an enzyme-linked immunosorbent assay (ELISA based antibody capture tests for LF. METHODS The recombinant antigens rWb14 and rWbT were expressed in Escherichia coli BL21 and an antibody capture ELISA was performed. For this, sera were used from microfilaremic individuals with W. bancrofti (MF, chronic pathology (CP, individuals infected with Strongyloides (SP and healthy controls from endemic (EN and non-endemic (NE areas. FINDINGS Both tests showed similar results, with 90% sensitivity and 96.6% specificity. In comparison with the BM14 ELISA commercial test, the Wb14 and WbT antigens performed with identical sensitivity but greater specificity. Reduced positivity with the CP suggested a potential to monitor cure. This was not confirmed, however, when sera from individuals up to seven years after treatment were assayed. MAIN CONCLUSIONS The Wb14 and WbT ELISAs were considered efficient and promising diagnostic tests. Due to the importance of antibody capture analysis to evaluate the Global Program to Eliminate Lymphatic Filariasis (GPELF, the tests proposed here appear as great alternatives to the available commercial system.

Precontrol observations on lymphatic filariasis & geo-helminthiases in two coastal districts of rural Orrisa.

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Chhotray, G P; Ranjit, M R; Khuntia, H K; Acharya, A S

2005-11-01

Lymphatic filariasis (LF) is a major public health problem in India, accounting for 40 per cent of the global burden. The World Health Organization has launched a global programme to eliminate LF by 2020 and India is a signatory to it. Orissa, an eastern Indian State has long been known to be endemic for LF. Prior to implementation of mass drug administration programme it is important to collect baseline data on filariasis and geo-helminthiases in the State. The present cross-sectional survey was therefore carried out between February and December 2001 to obtain baseline information on both LF and geo-helminthiases before application of the control measures. The study was carried out in rural areas of Puri and Ganjam districts in two phases. In phase I, the distribution of microfilaraemia in two district was mapped out in randomly selected primary health centres (PHCs), and 12 microfilaraemic villages were identified in each district by cluster analysis for the phase II study. In phase II, detailed clinical and parasitological survey for LF and geo-helminthiases was carried out following the standard procedures. Wuchereria bancrofti was found to be widely prevalent in Puri district with certain pockets of Brugia malayi while W. bancrofti was the only species in Ganjam district. The microfilaraemia (Mf) rate was found to be 9.5 and 11.1 per cent; and circulating filarial antigenaemia (CFA) was 16.8 and 17.8 per cent in Puri and Ganjam respectively. The geometric mean intensity (GMI) of Mf per ml of blood among positive individuals was 387 in Puri and 454 in Ganjam. The overall disease rate in Puri was 7.9 and 8.9 per cent in Ganjam. The prevalence of chronic manifestations was found to be significantly higher (PGanjam; and the heavy infection was found to be significantly higher (PGanjam compared to Puri district. The present study identified LF and geo-helminthiases as widely distributed health problem in rural areas of coastal Orissa which warrants intervention

Transmission assessment surveys (TAS to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.

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Brian K Chu

Full Text Available BACKGROUND: Lymphatic filariasis (LF is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA. Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low enough that it cannot be sustained even in the absence of drug intervention. Guidelines advanced by WHO call for a transmission assessment survey (TAS to determine if MDA can be stopped within an LF evaluation unit (EU after at least five effective rounds of annual treatment. To test the value and practicality of these guidelines, a multicenter operational research trial was undertaken in 11 countries covering various geographic and epidemiological settings. METHODOLOGY: The TAS was conducted twice in each EU with TAS-1 and TAS-2 approximately 24 months apart. Lot quality assurance sampling (LQAS formed the basis of the TAS survey design but specific EU characteristics defined the survey site (school or community, eligible population (6-7 year olds or 1(st-2(nd graders, survey type (systematic or cluster-sampling, target sample size, and critical cutoff (a statistically powered threshold below which transmission is expected to be no longer sustainable. The primary diagnostic tools were the immunochromatographic (ICT test for W. bancrofti EUs and the BmR1 test (Brugia Rapid or PanLF for Brugia spp. EUs. PRINCIPAL FINDINGS/CONCLUSIONS: In 10 of 11 EUs, the number of TAS-1 positive cases was below the critical cutoff, indicating that MDA could be stopped. The same results were found in the follow-up TAS-2, therefore, confirming the previous decision outcome. Sample sizes were highly sex and age-representative and closely matched the target value after factoring in estimates of non-participation. The TAS was determined to be a practical and effective evaluation tool for stopping MDA although its validity for longer-term post

The Global Programme to Eliminate Lymphatic Filariasis: History and achievements with special reference to annual single-dose treatment with diethylcarbamazine in Samoa and Fiji.

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Kimura, Eisaku

2011-03-01

Diethylcarbamazine (DEC), first introduced in 1947, was shown to have strong efficacy and safety for treatment of human lymphatic filariasis, which is caused mostly by a species Wuchereria bancrofti. Many studies to optimize the dosage and treatment schedule of DEC followed, and, based on the results, control programs with various regimens were implemented in different endemic areas/countries. By the mid 1970s, with endorsement by the WHO Expert Committee on Filariasis (3rd report, 1974), the standard DEC regimen for W. bancrofti infection in mass treatment had been established in principle: a total dose of 72 mg/kg of body weight given in 12 divided doses, once weekly or monthly, at 6 mg/kg each. Not long after the committee report, the efficacy of annual single-dose treatment at 6 mg/kg, which is only one twelfth of the WHO-recommended dose in a year, was reported effective in French Polynesia (study period: 1973-78), and later in Samoa (study period: 1979-81). These results were published between 1978 and 1985 in the Bulletin of WHO but received little attention. In the mid 1980s, the efficacy of ivermectin, the first-choice drug for onchocerciasis, against lymphatic filariae came to light. Since the effect at a single dose was remarkable, and often better than DEC, it was predicted that the newly introduced drug would replace DEC. Treatment experiments with ivermectin increased quickly in number. Meanwhile, annual single-dose mass drug administration (MDA) with DEC at 6 mg/kg was under scrutiny in Samoa and Fiji. In the early 1990s, the Samoan study, which covered the entire population of 160,000 with 3 annual MDAs, reported a significant reduction in microfilaria (mf) prevalence and mean mf density, while in Fiji, the efficacy of 5 rounds of annual MDA (total dose, 30 mg/kg) was shown to be as effective as 28 multi-dose MDA spread over 2 years (6 weekly plus 22 monthly treatments at 5 mg/kg; total dose, 140 mg/kg). Several additional studies carried out in

Modelling strategies to break transmission of lymphatic filariasis--aggregation, adherence and vector competence greatly alter elimination.

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Irvine, M A; Reimer, L J; Njenga, S M; Gunawardena, S; Kelly-Hope, L; Bockarie, M; Hollingsworth, T D

2015-10-22

With ambitious targets to eliminate lymphatic filariasis over the coming years, there is a need to identify optimal strategies to achieve them in areas with different baseline prevalence and stages of control. Modelling can assist in identifying what data should be collected and what strategies are best for which scenarios. We develop a new individual-based, stochastic mathematical model of the transmission of lymphatic filariasis. We validate the model by fitting to a first time point and predicting future timepoints from surveillance data in Kenya and Sri Lanka, which have different vectors and different stages of the control programme. We then simulate different treatment scenarios in low, medium and high transmission settings, comparing once yearly mass drug administration (MDA) with more frequent MDA and higher coverage. We investigate the potential impact that vector control, systematic non-compliance and different levels of aggregation have on the dynamics of transmission and control. In all settings, increasing coverage from 65 to 80 % has a similar impact on control to treating twice a year at 65 % coverage, for fewer drug treatments being distributed. Vector control has a large impact, even at moderate levels. The extent of aggregation of parasite loads amongst a small portion of the population, which has been estimated to be highly variable in different settings, can undermine the success of a programme, particularly if high risk sub-communities are not accessing interventions. Even moderate levels of vector control have a large impact both on the reduction in prevalence and the maintenance of gains made during MDA, even when parasite loads are highly aggregated, and use of vector control is at moderate levels. For the same prevalence, differences in aggregation and adherence can result in very different dynamics. The novel analysis of a small amount of surveillance data and resulting simulations highlight the need for more individual level data to be

Reassessment of areas with persistent Lymphatic Filariasis nine years after cessation of mass drug administration in Sri Lanka.

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Ramakrishna U Rao

2017-10-01

Full Text Available Sri Lanka was one of the first countries to initiate a lymphatic filariasis (LF elimination program based on WHO guidelines. The Anti-Filariasis Campaign provided 5 annual rounds of mass drug administration (MDA with diethylcarbamazine plus albendazole in all 8 endemic districts from 2002-2006. Microfilaremia (Mf prevalences have been consistently <1% in all sentinel and spot-check sites since 2006, and all evaluation units passed school-based transmission assessment surveys (TAS in 2013. We previously reported results from comprehensive surveillance studies conducted in 2011-2013 that documented low-level persistence of Wuchereria bancrofti in 19 high risk areas in 8 endemic districts. We now present results from repeat surveys conducted 3 to 4 years later in 6 areas that had the strongest LF signals in the prior study.The surveys assessed prevalence of filarial antigenemia (CFA and Mf in communities, CFA and anti-filarial antibody in school children (ages 6-8, and filarial DNA in Culex mosquitoes (molecular xenomonitoring, MX. Three study areas had significantly improved infection parameters compared to the prior study, but three other areas had little change. MX was more sensitive for detecting W. bancrofti persistence, and it was a better predictor than other parameters. Adult males accounted for more than 80% of infections detected in the study.These results suggest that W. bancrofti transmission was near the break point in some of the areas studied in 2011-13. LF is likely to decline to zero without further intervention in these areas, while other areas may require further intervention. Long term surveillance may be needed to verify W. bancrofti elimination in areas like Sri Lanka with efficient transmission by Culex. Test and treat or other programs targeting adult males plus bed net promotion may be more effective than MDA for clearing remaining hotspots of transmission in Sri Lanka.

Surgical management of morbidity due to lymphatic filariasis: the usefulness of a standardized international clinical classification of hydroceles.

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Capuano, G P; Capuano, C

2012-03-01

The objective of this work is to evaluate the usefulness of a standardized clinical classification of hydroceles in lymphatic filariasis endemic countries to guide their surgical management. 64 patients with hydroceles were operated in 2009-2010, in Level II hospitals (WHO classification), during two visits to Fiji, by the same mobile surgical team. The number of hydroceles treated was 83. We developed and evaluated a much needed clinical classification of hydroceles based on four criteria: Type (uni/bilateral); Side (left/right); Stage of enlargement of the scrotum rated from I to VI; Grade of burial of the penis rated from 0 to 4. It lead to the conclusion that 1) A Stage I or II hydrocele, associated with Grade 0 or 1 penis burial could be considered a "Simple Hydrocele". The surgical treatment is simple with no anticipated early complication. WHO Level II of health care structure seems adapted. 2) A Stage III or IV hydrocele associated with Grade 2, 3 or 4 penis burial could be considered a "Complicated Hydrocele". The operation is longer, more complicated and the possibility of occurrence of complications seems greater. A level III health care facility would be more adapted under the normal functioning of the health system. We conclude that a standardized clinical classification of hydroceles based on the Stage of enlargement of the scrotum and the Grade of burial of the penis appears to be a useful tool to guide the decision about the level of care and the surgical technique required. We use the same classification for penoscrotal lymphoedema. A decision tree is presented for the management of hydroceles in lymphatic filariasis endemic countries which could usefully complement the "Algorithm for management of scrotal swelling" proposed by WHO in 2002. An international classification system of hydroceles would also allow standardization and facilitate study design and comparisons of their results.

Lymphatic filariasis-specific immune responses in relation to lymphoedema grade and infection status. I. Cellular responses

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Nielsen, N. O.; Bloch, P.; Simonsen, P. E.

2002-01-01

leg lymphoedema of varying severity ranging from early to more advanced grades (pathology groups 1-5). Another group comprised individuals with mixed grades of lymphoedema and positive for mf and/or CFA (mixed pathology group). Three asymptomatic groups consisted of individuals without leg pathology...... in uninfected as compared to infected individuals. High levels of IL-10 were observed in asymptomatic individuals without infection and in asymptomatic CFA-positive but mf-negative individuals. Asymptomatic individuals with mf had relatively low IL-10 levels. Groups presenting with chronic pathology generally......The filariasis-specific cellular responsiveness was assessed in 109 adult individuals from a Wuchereria bancrofti-endemic area in north-east Tanzania. There were 9 study groups. Five groups of individuals were negative for microfilariae (mf) and specific circulating filarial antigen (CFA) and had...

Wuchereria bancrofti infection in Haitian immigrants and the risk of re-emergence of lymphatic filariasis in the Brazilian Amazon

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Edson Fidelis da Silva Junior

Full Text Available Abstract INTRODUCTION: Lymphatic filariasis (LF is a public health problem in Haiti. Thus, the emigration of Haitians to Brazil is worrisome because of the risk for LF re-emergence. METHODS: Blood samples of Haitian immigrants, aged ≥18 years, who emigrated to Manaus (Brazilian Amazon, were examined using thick blood smears, membrane blood filtration, and immunochromatography. RESULTS: Of the 244 immigrants evaluated, 1 (0.4% tested positive for W. bancrofti; 11.5% reported as having received LF treatment in Haiti. CONCLUSIONS: The re-emergence of LF in Manaus is unlikely, due to its low prevalence and low density of microfilaremia among the assessed Haitian immigrants.

Visible Leading: Principal Academy Connects and Empowers Principals

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Hindman, Jennifer; Rozzelle, Jan; Ball, Rachel; Fahey, John

2015-01-01

The School-University Research Network (SURN) Principal Academy at the College of William & Mary in Williamsburg, Virginia, has a mission to build a leadership development program that increases principals' instructional knowledge and develops mentor principals to sustain the program. The academy is designed to connect and empower principals…

Technetium-99m-Labeled Diethylcarbamazine Citrate (99mTc-DEC as a New Diagnostic Agent for Lymphatic Filariasis Detection

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N. K. Oekar

2017-11-01

Full Text Available Lymphatic filariasis or more commonly known as elephantiasis disease has infected more than 120 million people in 80 countries; and more than 40 million of them are unable to work, in addition to disruption of aesthetic values. The problem faced by almost all people in combating this infectious disease is delayed diagnosis. The sufferers do not realize that they have been infected with this disease. A specific and accurate method of early detection is therefore needed. 99mTc-labeled Diethylcarbamazine-citrate (99mTc-DEC has been successfully prepared. However, as part of the discovery and development of new drugs, the fulfillment of pharmaceutical and safety requirements have to be evaluated. Physico-chemical aspects such as stability, purity levels, and other pharmaceutical requirements, as well as pharmacokinetic studies and route of administration, are important parameters to be studied. The stability test showed that after seven months of storage, a preparation in a dry kit retains an efficiency of labeling and a purity level of more than 90 % and its physico-chemical and biological characteristics remained steady. Biodistribution test in Wistar rat showed that the greatest accumulation occurred in the lymphatic system, especially in the popliteal glands and in lumbar and mesenteric lymph nodes. Imaging with a gamma camera after intradermal and intravenous injections to the experimental animals resulted in a positive image that showed 99mTc-DEC accumulation in the target organ. The results of this innovation are expected to contribute significantly to improving public health, particulary in early detection of filarial infections. In addition, this result is expected to be a concrete contribution to the program of "The Global Goal of Elimination of Lymphatic Filariasis as a Public Health Problem by the Year 2020”.

A systematic review of factors that shape implementation of mass drug administration for lymphatic filariasis in sub-Saharan Africa.

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Silumbwe, Adam; Zulu, Joseph Mumba; Halwindi, Hikabasa; Jacobs, Choolwe; Zgambo, Jessy; Dambe, Rosalia; Chola, Mumbi; Chongwe, Gershom; Michelo, Charles

2017-05-22

Understanding factors surrounding the implementation process of mass drug administration for lymphatic filariasis (MDA for LF) elimination programmes is critical for successful implementation of similar interventions. The sub-Saharan Africa (SSA) region records the second highest prevalence of the disease and subsequently several countries have initiated and implemented MDA for LF. Systematic reviews have largely focused on factors that affect coverage and compliance, with less attention on the implementation of MDA for LF activities. This review therefore seeks to document facilitators and barriers to implementation of MDA for LF in sub-Saharan Africa. A systematic search of databases PubMed, Science Direct and Google Scholar was conducted. English peer-reviewed publications focusing on implementation of MDA for LF from 2000 to 2016 were considered for analysis. Using thematic analysis, we synthesized the final 18 articles to identify key facilitators and barriers to MDA for LF programme implementation. The main factors facilitating implementation of MDA for LF programmes were awareness creation through innovative community health education programmes, creation of partnerships and collaborations, integration with existing programmes, creation of morbidity management programmes, motivation of community drug distributors (CDDs) through incentives and training, and management of adverse effects. Barriers to implementation included the lack of geographical demarcations and unregistered migrations into rapidly urbanizing areas, major disease outbreaks like the Ebola virus disease in West Africa, delayed drug deliveries at both country and community levels, inappropriate drug delivery strategies, limited number of drug distributors and the large number of households allocated for drug distribution. Mass drug administration for lymphatic filariasis elimination programmes should design their implementation strategies differently based on specific contextual factors to

A systematic review of factors that shape implementation of mass drug administration for lymphatic filariasis in sub-Saharan Africa

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Adam Silumbwe

2017-05-01

Full Text Available Abstract Background Understanding factors surrounding the implementation process of mass drug administration for lymphatic filariasis (MDA for LF elimination programmes is critical for successful implementation of similar interventions. The sub-Saharan Africa (SSA region records the second highest prevalence of the disease and subsequently several countries have initiated and implemented MDA for LF. Systematic reviews have largely focused on factors that affect coverage and compliance, with less attention on the implementation of MDA for LF activities. This review therefore seeks to document facilitators and barriers to implementation of MDA for LF in sub-Saharan Africa. Methods A systematic search of databases PubMed, Science Direct and Google Scholar was conducted. English peer-reviewed publications focusing on implementation of MDA for LF from 2000 to 2016 were considered for analysis. Using thematic analysis, we synthesized the final 18 articles to identify key facilitators and barriers to MDA for LF programme implementation. Results The main factors facilitating implementation of MDA for LF programmes were awareness creation through innovative community health education programmes, creation of partnerships and collaborations, integration with existing programmes, creation of morbidity management programmes, motivation of community drug distributors (CDDs through incentives and training, and management of adverse effects. Barriers to implementation included the lack of geographical demarcations and unregistered migrations into rapidly urbanizing areas, major disease outbreaks like the Ebola virus disease in West Africa, delayed drug deliveries at both country and community levels, inappropriate drug delivery strategies, limited number of drug distributors and the large number of households allocated for drug distribution. Conclusion Mass drug administration for lymphatic filariasis elimination programmes should design their implementation

The "filarial dance" is not characteristic of filariasis: observations of "dancing megasperm" on high-resolution sonography in patients from nonendemic areas mimicking the filarial dance and a proposed mechanism for this phenomenon.

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Adejolu, Margaret; Sidhu, Paul S

2011-08-01

The objective of this series was to show that the sonographic appearance described as the "filarial dance" is not characteristic of filariasis but occurs in nonendemic areas as a manifestation of epididymal obstruction. An experienced observer documented cases after initial observation of the filarial dance in routine clinical practice using high-frequency linear array transducers. The filarial dance was described as excessive to-and-fro movement of echogenic particles within a prominent epididymis and graded 1 to 4 according to the extent and distribution of the abnormality. The country of birth, exposure to filarial infection or travel to a filarial-endemic area, previous scrotal surgery including vasectomy, any previous or current scrotal inflammatory disease, and any congenital testicular abnormalities were recorded. Over a 10-year period, sonographic appearances consistent with the filarial dance were observed in 18 patients (bilateral in 6). The mean patient age was 47.7 (range, 28-91) years. The abnormality was graded in the 24 affected testes as follows: grade 1, n = 3; grade 2, n = 8; grade 3, n = 8; and grade 4, n = 5. No patient had a history of filariasis or travel to an endemic area. Six of 18 patients (33.3%) had bilateral vasectomies; 5 (27.8%) had a history of epididymo-orchitis in the ipsilateral testis; 3 (16.7%) had previous scrotal surgery; and 4 (22.2%) had no relevant urologic history. We have described a sonographic appearance identical to the filarial dance in men with no history of filarial infection. Most had previous scrotal surgery or infection, suggesting that the filarial dance may not always be due to movement of filarial worms. The unifying condition in patients with filariasis and our patients is lymphatic obstruction, likely the underlying cause of the appearance in both groups.

The role of gender relations in uptake of mass drug administration for lymphatic filariasis in Alor District, Indonesia.

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Krentel, Alison; Wellings, Kaye

2018-03-12

The Global Programme to Eliminate Lymphatic Filariasis has set 2020 as a target to eliminate lymphatic filariasis (LF) as a public health problem through mass drug administration (MDA) to all eligible people living in endemic areas. To obtain a better understanding of compliance with LF treatment, a qualitative study using 43 in-depth interviews was carried out in Alor District, Indonesia to explore factors that motivate uptake of LF treatment, including the social and behavioural differences between compliant and non-compliant individuals. In this paper, we report on the findings specific to the role of family and gender relations and how they affect compliance. The sample comprised 21 men and 22 women; 24 complied with treatment while 19 did not. Gender relations emerged as a key theme in access, uptake and compliance with MDA. The view that the husband, as head of household, had the power, control, and in some cases the responsibility to influence whether his wife took the medication was common among both men and women. Gender also affected priorities for health care provision in the household as well as overall decision making regarding health in the household. Four models of responsibility for health decision making emerged: (i) responsibility resting primarily with the husband; (ii) responsibility resting primarily with the wife; (iii) responsibility shared equally by both husband and wife; and (iv) responsibility autonomously assumed by each individual for his or her own self, regardless of the course of action of the other spouse. (i) Gender relations and social hierarchy influence compliance with LF treatment because they inherently affect decisions taken within the household regarding health; (ii) health care interventions need to take account of the complexity of gender roles; (iii) the fact that women's power tends to be implicit and not overtly recognised in the household or the community has important implications for health care interventions; (iv

Progress and Impact of 13 Years of the Global Programme to Eliminate Lymphatic Filariasis on Reducing the Burden of Filarial Disease

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Ramaiah, K. D.; Ottesen, Eric A.

2014-01-01

Background A Global Programme to Eliminate Lymphatic Filariasis was launched in 2000, with mass drug administration (MDA) as the core strategy of the programme. After completing 13 years of operations through 2012 and with MDA in place in 55 of 73 endemic countries, the impact of the MDA programme on microfilaraemia, hydrocele and lymphedema is in need of being assessed. Methodology/Principal findings During 2000–2012, the MDA programme made remarkable achievements – a total of 6.37 billion treatments were offered and an estimated 4.45 billion treatments were consumed by the population living in endemic areas. Using a model based on empirical observations of the effects of treatment on clinical manifestations, it is estimated that 96.71 million LF cases, including 79.20 million microfilaria carriers, 18.73 million hydrocele cases and a minimum of 5.49 million lymphedema cases have been prevented or cured during this period. Consequently, the global prevalence of LF is calculated to have fallen by 59%, from 3.55% to 1.47%. The fall was highest for microfilaraemia prevalence (68%), followed by 49% in hydrocele prevalence and 25% in lymphedema prevalence. It is estimated that, currently, i.e. after 13 years of the MDA programme, there are still an estimated 67.88 million LF cases that include 36.45 million microfilaria carriers, 19.43 million hydrocele cases and 16.68 million lymphedema cases. Conclusions/Significance The MDA programme has resulted in significant reduction of the LF burden. Extension of MDA to all at-risk countries and to all regions within those countries where MDA has not yet reached 100% geographic coverage is imperative to further reduce the number of microfilaraemia and chronic disease cases and to reach the global target of interrupting transmission of LF by 2020. PMID:25412180

Chemical composition, toxicity and non-target effects of Pinus kesiya essential oil: An eco-friendly and novel larvicide against malaria, dengue and lymphatic filariasis mosquito vectors.

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Govindarajan, Marimuthu; Rajeswary, Mohan; Benelli, Giovanni

2016-07-01

Mosquitoes (Diptera: Culicidae) are vectors of important parasites and pathogens causing death, poverty and social disability worldwide, with special reference to tropical and subtropical countries. The overuse of synthetic insecticides to control mosquito vectors lead to resistance, adverse environmental effects and high operational costs. Therefore, the development of eco-friendly control tools is an important public health challenge. In this study, the mosquito larvicidal activity of Pinus kesiya leaf essential oil (EO) was evaluated against the malaria vector Anopheles stephensi, the dengue vector Aedes aegypti and the lymphatic filariasis vector Culex quinquefasciatus. The chemical composition of the EO was analyzed by gas chromatography-mass spectroscopy. GC-MS revealed that the P. kesiya EO contained 18 compounds. Major constituents were α-pinene, β-pinene, myrcene and germacrene D. In acute toxicity assays, the EO showed significant toxicity against early third-stage larvae of An. stephensi, Ae. aegypti and Cx. quinquefasciatus, with LC50 values of 52, 57, and 62µg/ml, respectively. Notably, the EO was safer towards several aquatic non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 values ranging from 4135 to 8390µg/ml. Overall, this research adds basic knowledge to develop newer and safer natural larvicides from Pinaceae plants against malaria, dengue and filariasis mosquito vectors. Copyright © 2016 Elsevier Inc. All rights reserved.

Loss of sensitivity of immunochromatographic test (ICT) for lymphatic filariasis diagnosis in low prevalence settings: consequence in the monitoring and evaluation procedures.

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Gounoue-Kamkumo, Raceline; Nana-Djeunga, Hugues C; Bopda, Jean; Akame, Julie; Tarini, Ann; Kamgno, Joseph

2015-12-23

Diagnostic tools for lymphatic filariasis (LF) elimination programs are useful in mapping the distribution of the disease, delineating areas where mass drug administrations (MDA) are required, and determining when to stop MDA. The prevalence and burden of LF have been drastically reduced following mass treatments, and the evaluation of the performance of circulating filarial antigen (CFA)-based assays was acknowledged to be of high interest in areas with low residual LF endemicity rates after multiple rounds of MDA. The objective of this study was therefore to evaluate the immunochromatographic test (ICT) sensitivity in low endemicity settings and, specifically, in individuals with low intensity of lymphatic filariasis infection. To perform this study, calibrated thick blood smears, ICT and Og4C3 enzyme-linked immunosorbent assay (ELISA) were carried out by night to identify Wuchereria bancrofti microfilarial and circulating filarial antigen carriers. A threshold determination assay regarding ICT and ELISA was performed using serial plasma dilutions from individuals with positive microfilarial counts. All individuals harbouring microfilariae (positive blood films) were detected by ICT and ELISA, but among individuals positive for ELISA, only 35.7 % of them were detected using ICT (Chi square: 4.57; p-value = 0.03), indicating a moderate agreement between both tests (kappa statistics = 0.49). Threshold determination analyses showed that ELISA was still positive at the last plasma dilution with negative ICT result. These findings suggest a loss of sensitivity for ICT in low endemicity settings, especially in people exhibiting low levels of circulating filarial antigen, raising serious concern regarding the monitoring and evaluation procedures in the framework of LF elimination program.

Biosynthesis, mosquitocidal and antibacterial properties of Toddalia asiatica-synthesized silver nanoparticles: do they impact predation of guppy Poecilia reticulata against the filariasis mosquito Culex quinquefasciatus?

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Murugan, Kadarkarai; Venus, Joseph Selvaraj Eugine; Panneerselvam, Chellasamy; Bedini, Stefano; Conti, Barbara; Nicoletti, Marcello; Sarkar, Santosh Kumar; Hwang, Jiang-Shiou; Subramaniam, Jayapal; Madhiyazhagan, Pari; Kumar, Palanisamy Mahesh; Dinesh, Devakumar; Suresh, Udaiyan; Benelli, Giovanni

2015-11-01

Mosquito-borne diseases represent a deadly threat for millions of people worldwide. Furthermore, pathogens and parasites polluting water also constitute a severe plague for populations of developing countries. In this study, silver nanoparticles (AgN) were biosynthesized a cheap aqueous extract of T. asiatica leaves as reducing and stabilizing agent. The formation of nanoparticle was confirmed by surface Plasmon resonance band illustrated in UV-vis spectrophotometer. AgN were characterized by FTIR, SEM, EDX, and XRD analyses. AgN were mostly spherical in shape, crystalline in nature, with face-centered cubic geometry, and their mean size was 25-30 nm. T. asiatica aqueous extract and green-synthesized AgN showed excellent larvicidal and pupicidal toxicity against the filariasis vector Culex quinqufasciatus, both in laboratory and field experiments. AgN LC50 ranged from 16.48 (I instar larvae) to 31.83 ppm (pupae). T. asiatica-synthesized were also highly effective in inhibiting growth of Bacillus subtilis, Klebsiella pneumoniae, and Salmonella typhi using the agar disk diffusion and minimum inhibitory concentration protocol. Lastly, we evaluated if sublethal doses of nanoparticles affect predation rates of fishes, Poecilia reticulata, against C. quinquefasciatus. In AgN-contaminated environment, predation of guppies against mosquito larvae was slightly higher over normal laboratory conditions. Overall, this study highlighted that T. asiatica-synthesized AgN are easy to produce, stable over time, and may be employed at low dosages to reduce populations of filariasis vectors, without detrimental effects on predation rates of mosquito natural enemies.

How elimination of lymphatic filariasis as a public health problem in the Kingdom of Cambodia was achieved.

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Khieu, Virak; Or, Vandine; Tep, Chhakda; Odermatt, Peter; Tsuyuoka, Reiko; Char, Meng Chuor; Brady, Molly A; Sidwell, Joshua; Yajima, Aya; Huy, Rekol; Ramaiah, Kapa D; Muth, Sinuon

2018-02-20

Endemicity of lymphatic filariasis (LF) in Cambodia was proven in 1956 when microfilariae were detected in mosquitos in the Kratié province. In 2001, an extensive study confirmed the presence of both Brugia malayi and Wuchereria bancrofti microfilariae. In 2003, the Ministry of Health established a national task force to develop policies and strategies for controlling and eliminating neglected tropical diseases (NTDs), with the goal of eliminating LF by 2015. This article summarizes the work accomplished to eliminate LF as a public health problem in Cambodia. The National Program to Eliminate Lymphatic Filariasis made excellent progress in the goal towards elimination due to strong collaboration between ministries, intensive supervision by national staff, and advocacy for mobilization of internal and external resources. Mass drug administration (MDA) with diethylcarbamazine citrate and albendazole was conducted in six implementation units, achieving > 70% epidemiological coverage for five consecutive rounds, from 2005 to 2009. In 2006, in 14 provinces, healthcare workers developed a line list of lymphedema and hydrocele patients, many of whom were > 40 years old and had been affected by LF for many years. The national program also trained healthcare workers and provincial and district staff in morbidity management and disability prevention, and designated health centers to provide care for lymphedema and acute attack. Two reference hospitals were designated to administer hydrocele surgery. Effectiveness of MDA was proven with transmission assessment surveys. These found that less than 1% of school children had antigenemia in 2010, which fell to 0% in both 2013 and 2015. A separate survey in one province in 2015 using Brugia Rapid tests to test for LF antibody found one child positive among 1677 children. The list of chronic LF patients was most recently updated and confirmed in 2011-2012, with 32 lymphoedema patients and 17 hydrocele patients listed. All

The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000-2007.

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Brian K Chu

2010-06-01

Full Text Available Between 2000-2007, the Global Programme to Eliminate Lymphatic Filariasis (GPELF delivered more than 1.9 billion treatments to nearly 600 million individuals via annual mass drug administration (MDA of anti-filarial drugs (albendazole, ivermectin, diethylcarbamazine to all at-risk for 4-6 years. Quantifying the resulting economic benefits of this significant achievement is important not only to justify the resources invested in the GPELF but also to more fully understand the Programme's overall impact on some of the poorest endemic populations.To calculate the economic benefits, the number of clinical manifestations averted was first quantified and the savings associated with this disease prevention then analyzed in the context of direct treatment costs, indirect costs of lost-labor, and costs to the health system to care for affected individuals. Multiple data sources were reviewed, including published literature and databases from the World Health Organization, International Monetary Fund, and International Labour OrganizationAn estimated US$21.8 billion of direct economic benefits will be gained over the lifetime of 31.4 million individuals treated during the first 8 years of the GPELF. Of this total, over US$2.3 billion is realized by the protection of nearly 3 million newborns and other individuals from acquiring lymphatic filariasis as a result of their being born into areas freed of LF transmission. Similarly, more than 28 million individuals already infected with LF benefit from GPELF's halting the progression of their disease, which results in an associated lifetime economic benefit of approximately US$19.5 billion. In addition to these economic benefits to at-risk individuals, decreased patient services associated with reduced LF morbidity saves the health systems of endemic countries approximately US$2.2 billion.MDA for LF offers significant economic benefits. Moreover, with favorable program implementation costs (largely a result of

Female Traditional Principals and Co-Principals: Experiences of Role Conflict and Job Satisfaction

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Eckman, Ellen Wexler; Kelber, Sheryl Talcott

2010-01-01

This paper presents a secondary analysis of survey data focusing on role conflict and job satisfaction of 102 female principals. Data were collected from 51 female traditional principals and 51 female co-principals. By examining the traditional and co-principal leadership models as experienced by female principals, this paper addresses the impact…

The Effect of Hygiene-Based Lymphedema Management in Lymphatic Filariasis-Endemic Areas: A Systematic Review and Meta-analysis.

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Meredith E Stocks

2015-10-01

Full Text Available Lymphedema of the leg and its advanced form, known as elephantiasis, are significant causes of disability and morbidity in areas endemic for lymphatic filariasis (LF, with an estimated 14 million persons affected worldwide. The twin goals of the World Health Organization's Global Program to Eliminate Lymphatic Filariasis include interrupting transmission of the parasitic worms that cause LF and providing care to persons who suffer from its clinical manifestations, including lymphedema-so-called morbidity management and disability prevention (MMDP. Scaling up of MMDP has been slow, in part because of a lack of consensus about the effectiveness of recommended hygiene-based interventions for clinical lymphedema.We conducted a systemic review and meta-analyses to estimate the effectiveness of hygiene-based interventions on LF-related lymphedema. We systematically searched PubMed, Embase, ISI Web of Knowledge, MedCarib, Lilacs, REPIDISCA, DESASTRES, and African Index Medicus databases through March 23, 2015 with no restriction on year of publication. Studies were eligible for inclusion if they (1 were conducted in an area endemic for LF, (2 involved hygiene-based interventions to manage lymphedema, and (3 assessed lymphedema-related morbidity. For clinical outcomes for which three or more studies assessed comparable interventions for lymphedema, we conducted random-effects meta-analyses. Twenty-two studies met the inclusion criteria and two meta-analyses were possible. To evaluate study quality, we developed a set of criteria derived from the GRADE methodology. Publication bias was assessed using funnel plots. Participation in hygiene-based lymphedema management was associated with a lower incidence of acute dermatolymphagioadenitis (ADLA, (Odds Ratio 0.32, 95% CI 0.25-0.40, as well as with a decreased percentage of patients reporting at least one episode of ADLA during follow-up (OR 0.29, 95% CI 0.12-0.47. Limitations included high heterogeneity

The Effect of Hygiene-Based Lymphedema Management in Lymphatic Filariasis-Endemic Areas: A Systematic Review and Meta-analysis.

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Stocks, Meredith E; Freeman, Matthew C; Addiss, David G

2015-10-01

Lymphedema of the leg and its advanced form, known as elephantiasis, are significant causes of disability and morbidity in areas endemic for lymphatic filariasis (LF), with an estimated 14 million persons affected worldwide. The twin goals of the World Health Organization's Global Program to Eliminate Lymphatic Filariasis include interrupting transmission of the parasitic worms that cause LF and providing care to persons who suffer from its clinical manifestations, including lymphedema-so-called morbidity management and disability prevention (MMDP). Scaling up of MMDP has been slow, in part because of a lack of consensus about the effectiveness of recommended hygiene-based interventions for clinical lymphedema. We conducted a systemic review and meta-analyses to estimate the effectiveness of hygiene-based interventions on LF-related lymphedema. We systematically searched PubMed, Embase, ISI Web of Knowledge, MedCarib, Lilacs, REPIDISCA, DESASTRES, and African Index Medicus databases through March 23, 2015 with no restriction on year of publication. Studies were eligible for inclusion if they (1) were conducted in an area endemic for LF, (2) involved hygiene-based interventions to manage lymphedema, and (3) assessed lymphedema-related morbidity. For clinical outcomes for which three or more studies assessed comparable interventions for lymphedema, we conducted random-effects meta-analyses. Twenty-two studies met the inclusion criteria and two meta-analyses were possible. To evaluate study quality, we developed a set of criteria derived from the GRADE methodology. Publication bias was assessed using funnel plots. Participation in hygiene-based lymphedema management was associated with a lower incidence of acute dermatolymphagioadenitis (ADLA), (Odds Ratio 0.32, 95% CI 0.25-0.40), as well as with a decreased percentage of patients reporting at least one episode of ADLA during follow-up (OR 0.29, 95% CI 0.12-0.47). Limitations included high heterogeneity across studies

Pilot Assessment of Soil-Transmitted Helminthiasis in the Context of Transmission Assessment Surveys for Lymphatic Filariasis in Benin and Tonga

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Chu, Brian K.; Gass, Katherine; Batcho, Wilfrid; 'Ake, Malakai; Dorkenoo, Améyo M.; Adjinacou, Elvire; Mafi, 'Eva; Addiss, David G.

2014-01-01

Background Mass drug administration (MDA) for lymphatic filariasis (LF) programs has delivered more than 2 billion treatments of albendazole, in combination with either ivermectin or diethylcarbamazine, to communities co-endemic for soil-transmitted helminthiasis (STH), reducing the prevalence of both diseases. A transmission assessment survey (TAS) is recommended to determine if MDA for LF can be stopped within an evaluation unit (EU) after at least five rounds of annual treatment. The TAS also provides an opportunity to simultaneously assess the impact of these MDAs on STH and to determine the frequency of school-based MDA for STH after community-wide MDA is no longer needed for LF. Methodology/Principal Findings Pilot studies conducted in Benin and Tonga assessed the feasibility of a coordinated approach. Of the schools (clusters) selected for a TAS in each EU, a subset of 5 schools per STH ecological zone was randomly selected, according to World Health Organization (WHO) guidelines, for the coordinated survey. In Benin, 519 children were sampled in 5 schools and 22 (4.2%) had STH infection (A. lumbricoides, T. trichiura, or hookworm) detected using the Kato-Katz method. All infections were classified as light intensity under WHO criteria. In Tonga, 10 schools were chosen for the coordinated TAS and STH survey covering two ecological zones; 32 of 232 (13.8%) children were infected in Tongatapu and 82 of 320 (25.6%) in Vava'u and Ha'apai. All infections were light-intensity with the exception of one with moderate-intensity T. trichiura. Conclusions Synchronous assessment of STH with TAS is feasible and provides a well-timed evaluation of infection prevalence to guide ongoing treatment decisions at a time when MDA for LF may be stopped. The coordinated field experiences in both countries also suggest potential time and cost savings. Refinement of a coordinated TAS and STH sampling methodology should be pursued, along with further validation of alternative

Pilot assessment of soil-transmitted helminthiasis in the context of transmission assessment surveys for lymphatic filariasis in Benin and Tonga.

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Brian K Chu

2014-02-01

Full Text Available BACKGROUND: Mass drug administration (MDA for lymphatic filariasis (LF programs has delivered more than 2 billion treatments of albendazole, in combination with either ivermectin or diethylcarbamazine, to communities co-endemic for soil-transmitted helminthiasis (STH, reducing the prevalence of both diseases. A transmission assessment survey (TAS is recommended to determine if MDA for LF can be stopped within an evaluation unit (EU after at least five rounds of annual treatment. The TAS also provides an opportunity to simultaneously assess the impact of these MDAs on STH and to determine the frequency of school-based MDA for STH after community-wide MDA is no longer needed for LF. METHODOLOGY/PRINCIPAL FINDINGS: Pilot studies conducted in Benin and Tonga assessed the feasibility of a coordinated approach. Of the schools (clusters selected for a TAS in each EU, a subset of 5 schools per STH ecological zone was randomly selected, according to World Health Organization (WHO guidelines, for the coordinated survey. In Benin, 519 children were sampled in 5 schools and 22 (4.2% had STH infection (A. lumbricoides, T. trichiura, or hookworm detected using the Kato-Katz method. All infections were classified as light intensity under WHO criteria. In Tonga, 10 schools were chosen for the coordinated TAS and STH survey covering two ecological zones; 32 of 232 (13.8% children were infected in Tongatapu and 82 of 320 (25.6% in Vava'u and Ha'apai. All infections were light-intensity with the exception of one with moderate-intensity T. trichiura. CONCLUSIONS: Synchronous assessment of STH with TAS is feasible and provides a well-timed evaluation of infection prevalence to guide ongoing treatment decisions at a time when MDA for LF may be stopped. The coordinated field experiences in both countries also suggest potential time and cost savings. Refinement of a coordinated TAS and STH sampling methodology should be pursued, along with further validation of

GAMBARAN IgG4 dan IgE TERHADAP PROTEIN MIKROFILARIA PADA SERA PENDUDUK ENDEMIS FILARIASIS DI KECAMATAN PASIR PENYU, RIAU

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Basundari SU

2012-09-01

Full Text Available Western blot test to detect specific IgG4 and IgE was performed to 12 microfilaraemic and 13 amicrofilaraemic individuals from malayan filariasis endemic area, Pasir Penyu, Riau. No differences in binding patterns of IgG4 and IgE antibodies to microfUarial protein components was shown. There was a parallel protein components recognition by IgG4 and IgE of molecular weight ranging from 158 kd to 14 kd. Protein component of 125 kd was only recognized by IgG4 and of 112 kd only by IgE. These findings suggest that in filarial infection IgG4 antibodies play a role as a blocking antibodies to inhibit the spesific reaction of IgE that is usually expressed as an allergic reaction.

A mathematical model for long-term effect of diethylcarbamazine-albendazole mass drug administration on lymphatic filariasis

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Tasman, H.; Supali, T.; Supriatna, A. K.; Nuraini, N.; Soewono, E.

2015-03-01

In this paper we discuss a mathematical model for the transmission of lymphatic filariasis disease. The human population is divided into susceptible, latent, acute and chronic subpopulations. Treatment is carried out within the scheme of mass drug administration (MDA) by giving the diethylcarbamazine (DEC) and albendazole (ALB) to all individuals. In the model, we assume that the treatments have direct killing effect to microfilariae, increase of immune-mediated effect. The treated individuals are assumed to remain susceptible to the disease. This is due to the fact that the treatment is only partially effective against macrofilaria. Simulations of the model reveals that DEC-ALB treatment does give significant reduction of acute and chronic compartments at the end of the treatment period and slow down the growth after the treatment before eventually tend to the endemic state. It showed that repeated treatment during MDA is effective to decrease the transmission. This suggests that terminating MDA program after a long period of its application may still effective in controlling the disease.

Stigma reduction and improved knowledge and attitudes towards filariasis using a comic book for children.

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el-Setouhy, Maged A; Rio, Francisco

2003-04-01

WHO has initiated a global program for lymphatic filariasis (LF) elimination by year 2020. A comic book was designed to improve knowledge and attitudes of Egyptian school children, which included messages on the acceptability of Mass Drug Administration (MDA) and stigma reduction. Comic book administration significantly reduced the fear of the studied children from LF as a killer disease. It helped in positively changing the attitudes of the children towards Elephantiasis patients (p-value comic book also reduced the number of children who had earlier stated that they would avoid someone with LF. Knowledge about the ability of treating and preventing LF was also significantly increased among the children after reading the comic book. Moreover, comic book reading helped in raising the awareness towards MDA as the method of choice in preventing LF. Most of the children liked the comic book and its contents. Importantly, 96.2% found this book easy to understand. Many of relatives and friends read the comic book within 2 weeks after distribution. A well-accepted comic book for children is a proven way to reduce stigma and increase knowledge about disease prevention and treatment.

Lymphatic filariasis in Papua New Guinea: distribution at district level and impact of mass drug administration, 1980 to 2011

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2013-01-01

Background Lymphatic filariasis (LF) caused by Wuchereria bancrofti is present at high prevalence in some parts of Papua New Guinea. However, there has been no rigorous data-based representative assessment of nationwide prevalence of LF. The LF programme has been daunted by the scope of the problem, and progress on mass drug administration (MDA) has been slow and lacking in resources. Methods A systematic literature review identified LF surveys in Papua New Guinea between 1980 and 2011. Results were extracted by location, time period and test used (blood slide, immunochromatographic test (ICT) or Og4C3 ELISA) and combined by district. Three criteria schemes based on the Global Programme to Eliminate Lymphatic Filariasis guidelines, with modifications, were developed to classify and prioritize districts by prevalence level. Results of repeated surveys in the same sites were used to investigate the impact of MDA on LF prevalence over the time period. Results There were 312 distinct survey sites identified in 80 of the 89 districts over the 31-year period. The overall LF prevalence in the sites tested was estimated at 18.5 to 27.5% by blood slide for microfilariae (Mf), 10.1% to 12.9% by ICT and 45.4% to 48.8% by Og4C3. Biases in site selection towards areas with LF, and change in type of assay used, affected the prevalence estimates, but overall decline in prevalence over the time period was observed. Depending on the criteria used, 34 to 36 districts (population 2.7 to 2.9 million) were classed as high endemic (≥5% prevalence), 15 to 25 districts (1.7 to 1.9 million) as low endemic (Papua New Guinea enables better estimation of the national burden, identifies gaps in knowledge, quantifies and locates the population at risk, and can be used to predict the likely impact of MDA and/or vector control. Better targeting of districts by level of prevalence will strengthen the control programme, facilitate monitoring of the disease trend and increase the likelihood of

Assessing transmission of lymphatic filariasis using parasitologic, serologic, and entomologic tools after mass drug administration in American Samoa.

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Mladonicky, Janice M; King, Jonathan D; Liang, Jennifer L; Chambers, Eric; Pa'au, Molisamoa; Schmaedick, Mark A; Burkot, Thomas R; Bradley, Mark; Lammie, Patrick J

2009-05-01

Assessing the interruption of lymphatic filariasis transmission after annual mass drug administration (MDA) requires a better understanding of how to interpret results obtained with the available diagnostic tools. We conducted parasitologic, serologic, and entomologic surveys in three villages in American Samoa after sentinel site surveys suggested filarial antigen prevalence was < 1% after five annual MDAs with diethylcarbamazine and albendazole. Antigen and antifilarial antibody prevalence ranged from 3.7% to 4.6% and from 12.5% to 14.9%, respectively, by village. Only one person was microfilaria positive. Although no children less than 10 years of age were antigen positive, antifilarial antibody prevalence in this age group was 5.1% and antibody-positive children were detected in all three villages. Wuchereria bancrofti-infected mosquitoes were also detected in all three villages. Thus, monitoring of infections in mosquitoes and antifilarial antibody levels in children may serve as indicators of local transmission and be useful for making decisions about program endpoints.

Assessment of the burden of soil-transmitted helminthiasis after five years of mass drug administration for Onchocerciasis and Lymphatic filariasis in Kebbi State, Nigeria

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Akinola Stephen Oluwole

2017-05-01

Full Text Available There is a hypothesis that Mass drug administration (MDA of ivermectin and albendazole for the treatment of onchocerciasis and lymphatic filariasis could have an impact on the burden of soil-transmitted helminthiasis (STH in MDA communities. We, therefore, assessed the burden of STH (Ascaris lumbricoides, Trichuris trichiura, and hookworm infections in nine communities from 3 LGAs (two MDA local government areas (LGAs and one control LGA in Kebbi State, Nigeria after 5-years (2010–2015 of MDA for onchocerciasis and/or lymphatic filariasis. We also administered questionnaire to obtain demographic information and history of MDA in the past five years. The three LGAs are Bagudo (Ivermectin MDA; Zuru (Ivermectin/Albendazole MDA and Dandi (No MDA. The study was a cross sectional survey. The total number of people that complied with provision of stool samples and questionnaire were 1357 persons; stool samples collected were examined for STH infections in the three LGAs. Zuru LGA had the highest prevalence of STH (41.89, 95% CI: 37.08–46.81 followed by Dandi LGA (24.66, 95% CI: 20.69–28.97 and Bagudo LGA (3.36, 95% CI: 1.97–5.32. Prevalence of STH infection was not significantly different among age group and sex. Geometric mean intensity per gram of infection for both A. lumbricoides and Hookworm were highest in Zuru LGA with (1.16 GMI, 95% CI: 0.97–1.36 and (1.49 GMI, 95% CI: 1.29–1.70 respectively. Treatment coverage was less than 65% from 2010 to 2013 in the intervention LGAs. The study shows that STH is still a public health problem in Zuru LGA (IVM + ALB and requires MDA of albendazole for STH control to continue, while Dandi LGA (No MDA history requires MDA with albendazole to scale up treatment for STH control.

29 CFR 1471.995 - Principal.

Science.gov (United States)

2010-07-01

... SUSPENSION (NONPROCUREMENT) Definitions § 1471.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or... 29 Labor 4 2010-07-01 2010-07-01 false Principal. 1471.995 Section 1471.995 Labor Regulations...

Portraits of Principal Practice: Time Allocation and School Principal Work

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Sebastian, James; Camburn, Eric M.; Spillane, James P.

2018-01-01

Purpose: The purpose of this study was to examine how school principals in urban settings distributed their time working on critical school functions. We also examined who principals worked with and how their time allocation patterns varied by school contextual characteristics. Research Method/Approach: The study was conducted in an urban school…

PREVALENCE OF LYMPHATIC FILARIASIS, MALARIA AND SOIL TRANSMITTED HELMINTHIASIS IN A COMMUNITY OF BARDIYA DISTRICT, WESTERN NEPAL.

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Ranjitkar, Samir; Alifrangis, Michael; Adhikari, Madhav; Olsen, Annette; Simonsen, Paul E; Meyrowitsch, Dan Wolf

2014-11-01

Lymphatic filariasis (LF), malaria and soil transmitted helminthiasis (STH) cause major health problems in Nepal, but in spite of this very few stud- ies have been carried out on these parasitic infections in Nepal. A cross sectional survey of all three categories of parasitic infections was carried out in Deuda- kala Village of Bardiya District, western Nepal. A total of 510 individuals aged 5 years and above were examined from finger prick blood for circulating filarial antigen (CFA), malaria antigen using a rapid diagnostic test (RDT), and malaria DNA using a PCR-based assay. In addition, 317 individuals were examined for soil-transmitted helminth (STH) eggs by the Kato-Katz technique. Prevalence of LF, malaria (antigen) and STH infection was 25.1%, 0.6% and 18.3%, respectively. PCR analysis did not detect any additional malaria cases. The prevalence of LF and STH infections differ significantly among different age groups and ethnic communities. The high prevalence of LF in the community studied indicates an immediate need for implementing a mass drug administration program for its control in this particular geographical area of Nepal.

31 CFR 19.995 - Principal.

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2010-07-01

... SUSPENSION (NONPROCUREMENT) Definitions § 19.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or supervisory... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Principal. 19.995 Section 19.995...

22 CFR 208.995 - Principal.

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2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Principal. 208.995 Section 208.995 Foreign...) Definitions § 208.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or supervisory responsibilities related to a...

22 CFR 1006.995 - Principal.

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2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Principal. 1006.995 Section 1006.995 Foreign... § 1006.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or supervisory responsibilities related to a...

2 CFR 180.995 - Principal.

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2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Principal. 180.995 Section 180.995 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET GOVERNMENTWIDE GUIDANCE FOR GRANTS AND AGREEMENTS... § 180.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator...

22 CFR 1508.995 - Principal.

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2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Principal. 1508.995 Section 1508.995 Foreign...) Definitions § 1508.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or supervisory responsibilities related to a...

Principal stratification in causal inference.

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Frangakis, Constantine E; Rubin, Donald B

2002-03-01

Many scientific problems require that treatment comparisons be adjusted for posttreatment variables, but the estimands underlying standard methods are not causal effects. To address this deficiency, we propose a general framework for comparing treatments adjusting for posttreatment variables that yields principal effects based on principal stratification. Principal stratification with respect to a posttreatment variable is a cross-classification of subjects defined by the joint potential values of that posttreatment variable tinder each of the treatments being compared. Principal effects are causal effects within a principal stratum. The key property of principal strata is that they are not affected by treatment assignment and therefore can be used just as any pretreatment covariate. such as age category. As a result, the central property of our principal effects is that they are always causal effects and do not suffer from the complications of standard posttreatment-adjusted estimands. We discuss briefly that such principal causal effects are the link between three recent applications with adjustment for posttreatment variables: (i) treatment noncompliance, (ii) missing outcomes (dropout) following treatment noncompliance. and (iii) censoring by death. We then attack the problem of surrogate or biomarker endpoints, where we show, using principal causal effects, that all current definitions of surrogacy, even when perfectly true, do not generally have the desired interpretation as causal effects of treatment on outcome. We go on to forrmulate estimands based on principal stratification and principal causal effects and show their superiority.

Principals' Salaries, 2007-2008

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Cooke, Willa D.; Licciardi, Chris

2008-01-01

How do salaries of elementary and middle school principals compare with those of other administrators and classroom teachers? Are increases in salaries of principals keeping pace with increases in salaries of classroom teachers? And how have principals' salaries fared over the years when the cost of living is taken into account? There are reliable…

21 CFR 1404.995 - Principal.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Principal. 1404.995 Section 1404.995 Food and...) Definitions § 1404.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or supervisory responsibilities related to a...

34 CFR 85.995 - Principal.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Principal. 85.995 Section 85.995 Education Office of...) Definitions § 85.995 Principal. Principal means— (a) An officer, director, owner, partner, principal investigator, or other person within a participant with management or supervisory responsibilities related to a...

Principal Self-Efficacy and Work Engagement: Assessing a Norwegian Principal Self-Efficacy Scale

Science.gov (United States)

Federici, Roger A.; Skaalvik, Einar M.

2011-01-01

One purpose of the present study was to develop and test the factor structure of a multidimensional and hierarchical Norwegian Principal Self-Efficacy Scale (NPSES). Another purpose of the study was to investigate the relationship between principal self-efficacy and work engagement. Principal self-efficacy was measured by the 22-item NPSES. Work…

Persistent 'hotspots' of lymphatic filariasis microfilaraemia despite 14 years of mass drug administration in Ghana.

Science.gov (United States)

Biritwum, Nana-Kwadwo; Yikpotey, Paul; Marfo, Benjamin K; Odoom, Samuel; Mensah, Ernest O; Asiedu, Odame; Alomatu, Bright; Hervie, Edward T; Yeboah, Abednego; Ade, Serge; Hinderaker, Sven G; Reid, Anthony; Takarinda, Kudakwashe C; Koudou, Benjamin; Koroma, Joseph B

2016-12-01

Among the 216 districts in Ghana, 98 were declared endemic for lymphatic filariasis in 1999 after mapping. Pursuing the goal of elimination, WHO recommends annual treatment using mass drugs administration (MDA) for at least 5 years. MDA was started in the country in 2001 and reached national coverage in 2006. By 2014, 69 districts had 'stopped-MDA' (after passing the transmission assessment survey) while 29 others remained with persistent microfilaraemia (mf) prevalence (≥1%) despite more than 11 years of MDA and were classified as 'hotspots'. An ecological study was carried out to compare baseline mf prevalence and anti-microfilaria interventions between hotspot and stopped-MDA districts. Baseline mf prevalence was significantly higher in hotspots than stopped-MDA districts (photspot districts, but it was still higher than in stopped-MDA districts. The number of MDA rounds was slightly higher in hotspot districts (photspots and stopped-MDA districts was a high baseline mf prevalence. This finding indicates that the recommended 5-6 rounds annual treatment may not achieve interruption of transmission. © The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

An Investigation of Teacher, Principal, and Superintendent Perceptions on the Ability of the National Framework for Principal Evaluations to Measure Principals' Leadership Competencies

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Lamb, Lori D.

2014-01-01

The purpose of this qualitative study was to investigate the perceptions of effective principals' leadership competencies; determine if the perceptions of teachers, principals, and superintendents aligned with the proposed National Framework for Principal Evaluations initiative. This study examined the six domains of leadership outlined by the…

STUDIES OF FILARIASIS IN KEBAN AGUNG AND GUNUNG AGUNG VILLAGES IN SOUTH BENGKULU, SUMATERA, INDONESIA : II Field identification of Mansonia Bonneae and Mansonia Dives

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Suwarto Suwarto

2012-09-01

Full Text Available Nyamuk Mansonia bonneae/dives adalah vektor potensial untuk penyakit filariasis malayi. Dua species ini mempunyai bentuk morfologi yang mirip sekali hanya dibedakan dengan ada tidaknya sisik-sisik di antara rambut-rambut di atas pangkal sayap (supra-alar scale dan bentuk gigi sisir (comb teeth pada tergit segmen abdomen ke-8. Sisik-sisik di atas pangkal sayap tersebut mudah sekali lepas sehingga sulit untuk membedakan Ma. dives dan Ma. bonneae. Penelitian untuk membedakan dua species ini secara morfologi telah dikerjakan yang kemudian hasilnya dicocokkan dengan bentuk gigi sisir untuk masing-masing species. Hasil pengamatan secara morfologi ternyata, setelah dicocokkan dengan gigi sisir dari masing-masing specimen, Ma. dives mempunyai kesalahan identifikasi sebesar 6% sedang Ma bonneae 11,3%.

Change in composition of the Anopheles gambiae complex and its possible implications for the transmission of malaria and lymphatic filariasis in north-eastern Tanzania

DEFF Research Database (Denmark)

Derua, Yahya A; Alifrangis, Michael; Hosea, Kenneth M

2012-01-01

ABSTRACT: BACKGROUND: A dramatic decline in the incidence of malaria due to Plasmodium falciparum infection in coastal East Africa has recently been reported to be paralleled (or even preceded) by an equally dramatic decline in malaria vector density, despite absence of organized vector control. ...... to differences in biology and vectorial capacity of the An. gambiae s.l. complex the change in sibling species composition will have important implications for the epidemiology and control of malaria and lymphatic filariasis in the study area.......ABSTRACT: BACKGROUND: A dramatic decline in the incidence of malaria due to Plasmodium falciparum infection in coastal East Africa has recently been reported to be paralleled (or even preceded) by an equally dramatic decline in malaria vector density, despite absence of organized vector control...

Experiences of a Community-Based Lymphedema Management Program for Lymphatic Filariasis in Odisha State, India: An Analysis of Focus Group Discussions with Patients, Families, Community Members and Program Volunteers.

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Tali Cassidy

2016-02-01

Full Text Available Globally 68 million people are infected with lymphatic filariasis (LF, 17 million of whom have lymphedema. This study explores the effects of a lymphedema management program in Odisha State, India on morbidity and psychosocial effects associated with lymphedema.Focus groups were held with patients (eight groups, separated by gender, their family members (eight groups, community members (four groups and program volunteers (four groups who had participated in a lymphedema management program for the past three years. Significant social, physical, and economic difficulties were described by patients and family members, including marriageability, social stigma, and lost workdays. However, the positive impact of the lymphedema management program was also emphasized, and many family and community members indicated that community members were accepting of patients and had some improved understanding of the etiology of the disease. Program volunteers and community members stressed the role that the program had played in educating people, though interestingly, local explanations and treatments appear to coexist with knowledge of biomedical treatments and the mosquito vector.Local and biomedical understandings of disease can co-exist and do not preclude individuals from participating in biomedical interventions, specifically lymphedema management for those with lymphatic filariasis. There is a continued need for gender-specific psychosocial support groups to address issues particular to men and women as well as a continued need for improved economic opportunities for LF-affected patients. There is an urgent need to scale up LF-related morbidity management programs to reduce the suffering of people affected by LF.

RE Rooted in Principal's Biography

NARCIS (Netherlands)

ter Avest, Ina; Bakker, C.

2017-01-01

Critical incidents in the biography of principals appear to be steering in their innovative way of constructing InterReligious Education in their schools. In this contribution, the authors present the biographical narratives of 4 principals: 1 principal introducing interreligious education in a

Situational analysis of lymphatic filariasis morbidity in Ahanta West District of Ghana.

Science.gov (United States)

Stanton, Michelle C; Best, Abigail; Cliffe, Matthew; Kelly-Hope, Louise; Biritwum, Nana-Kwadwo; Batsa, Linda; Debrah, Alex

2016-02-01

Situational analysis of lymphatic filariasis (LF) morbidity and its management in Ahanta West, Ghana, to identify potential barrier to healthcare for LF patients. Lymphoedema and hydrocoele patients were identified by community health workers from a subset of villages, and were interviewed and participated in focus group discussions to determine their attitudes and practices towards managing their morbidity, and their perceived barriers to accessing care. Local health professionals were also interviewed to obtain their views on the availability of morbidity management services in the district. Sixty-two patients (34 lymphoedema and 28 hydrocoeles) and 13 local health professionals were included in the study. Lymphoedema patients predominantly self-managed their conditions, which included washing with soap and water (61.8%), and exercising the affected area (52.9%). Almost 65% of patients had sought medical assistance at some stage, but support was generally limited to receiving tablets (91%). Local health professionals reported rarely seeing lymphoedema patients, citing stigma and lack of provisions to assist patients as a reason for this. Almost half of hydrocoele patients (44%) chose not to seek medical assistance despite the negative impact it had on their lives. Whilst surgery itself is free with national health insurance, 63% those who had not sought treatment stated that indirect costs of surgery (travel costs, loss of earnings, etc.) were the most prohibitive factor to seeking treatment. The information obtained from this study should now be used to guide future morbidity strategies in building a stronger relationship between the local health services and LF patients, to ultimately improve patients' physical, psychological and economic wellbeing. © 2015 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd.

Redesigning Principal Internships: Practicing Principals' Perspectives

Science.gov (United States)

Anast-May, Linda; Buckner, Barbara; Geer, Gregory

2011-01-01

Internship programs too often do not provide the types of experiences that effectively bridge the gap between theory and practice and prepare school leaders who are capable of leading and transforming schools. To help address this problem, the current study is directed at providing insight into practicing principals' views of the types of…

The Future of Principal Evaluation

Science.gov (United States)

Clifford, Matthew; Ross, Steven

2012-01-01

The need to improve the quality of principal evaluation systems is long overdue. Although states and districts generally require principal evaluations, research and experience tell that many state and district evaluations do not reflect current standards and practices for principals, and that evaluation is not systematically administered. When…

Preparing Principals as Instructional Leaders: Perceptions of University Faculty, Expert Principals, and Expert Teacher Leaders

Science.gov (United States)

Taylor Backor, Karen; Gordon, Stephen P.

2015-01-01

Although research has established links between the principal's instructional leadership and student achievement, there is considerable concern in the literature concerning the capacity of principal preparation programs to prepare instructional leaders. This study interviewed educational leadership faculty as well as expert principals and teacher…

Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents.

Science.gov (United States)

Gordon, Susan; Melrose, Wayne; Warner, Jeffrey; Buttner, Petra; Ward, Leigh

2011-07-01

Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.

Lymphatic Filariasis: A Method to Identify Subclinical Lower Limb Change in PNG Adolescents

Science.gov (United States)

Gordon, Susan; Melrose, Wayne; Warner, Jeffrey; Buttner, Petra; Ward, Leigh

2011-01-01

Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity. PMID:21811644

Predicting lymphatic filariasis transmission and elimination dynamics using a multi-model ensemble framework

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Morgan E. Smith

2017-03-01

Full Text Available Mathematical models of parasite transmission provide powerful tools for assessing the impacts of interventions. Owing to complexity and uncertainty, no single model may capture all features of transmission and elimination dynamics. Multi-model ensemble modelling offers a framework to help overcome biases of single models. We report on the development of a first multi-model ensemble of three lymphatic filariasis (LF models (EPIFIL, LYMFASIM, and TRANSFIL, and evaluate its predictive performance in comparison with that of the constituents using calibration and validation data from three case study sites, one each from the three major LF endemic regions: Africa, Southeast Asia and Papua New Guinea (PNG. We assessed the performance of the respective models for predicting the outcomes of annual MDA strategies for various baseline scenarios thought to exemplify the current endemic conditions in the three regions. The results show that the constructed multi-model ensemble outperformed the single models when evaluated across all sites. Single models that best fitted calibration data tended to do less well in simulating the out-of-sample, or validation, intervention data. Scenario modelling results demonstrate that the multi-model ensemble is able to compensate for variance between single models in order to produce more plausible predictions of intervention impacts. Our results highlight the value of an ensemble approach to modelling parasite control dynamics. However, its optimal use will require further methodological improvements as well as consideration of the organizational mechanisms required to ensure that modelling results and data are shared effectively between all stakeholders.

School Principals' Emotional Coping Process

Science.gov (United States)

Poirel, Emmanuel; Yvon, Frédéric

2014-01-01

The present study examines the emotional coping of school principals in Quebec. Emotional coping was measured by stimulated recall; six principals were filmed during a working day and presented a week later with their video showing stressful encounters. The results show that school principals experience anger because of reproaches from staff…

Studies of Anopheles gambiae s.l (Diptera: Culicidae) exhibiting different vectorial capacities in lymphatic filariasis transmission in the Gomoa district, Ghana.

Science.gov (United States)

Amuzu, Hilaria; Wilson, Michael D; Boakye, Daniel A

2010-09-14

Two lymphatic filariasis endemic communities Mampong and Hwida in Ghana have been regularly monitored for impact on transmission after annual mass drug administration (MDA) with albendazole and ivermectin. After six MDAs even though the ABR for Mampong was 55883/person/year and that of Hwida was 2494/person/year, they both had ATPs of 15.21 infective larvae/person/year. Interestingly the human microfilaraemia levels had reduced significantly from 14% to 0% at Mampong and 12% to 3% at Hwida. In an attempt to understand this anomaly, we collected mosquitoes over a 5-month period using human landing catches to determine the species composition, the number of cibarial teeth, the lengths and widths of the cibarium and the cibarial dome of the vector populations. Out of 2553 mosquitoes caught at Mampong, 42.6% were An. gambiae s.l. All 280 identified further by PCR were An. gambiae s.s (275 M and 5 S molecular forms). At Hwida, 112 mosquitoes were obtained; 67 (59.8%) were An. gambiae s.l, comprised of 40 (59.7%) An. melas, 24 (35.8%) An. gambiae s.s (17 and 5 M and S molecular forms respectively) and 3 (4.5%) unidentified. The mean number of teeth for An. melas was 14.1 (median = 14, range = 12-15), An. gambiae s.s., 15.7 (median = 15, range = 13-19) M form 15.5 (median = 15 range = 13-19) and S form 16 (median = 16, range 15-17). The observed differences in teeth numbers were significantly different between An. melas and An. gambiae s.s (p = 0.004), and the M form (p = 0.032) and the S form (p = 0.002). In this study, An. gambiae s.s was the main vector at Mampong and was found to possess significantly more cibarial teeth than An. melas, the principal vector at Hwida. We postulate that the different impact observed after 6 MDAs may be due to An. gambiae s.s exhibiting 'facilitation' at Mampong and at Hwida An. melas the main vector exhibits 'limitation'. Thus it may be necessary to compliment MDA with vector control to achieve interruption of transmission in areas

Principal Time Management Skills: Explaining Patterns in Principals' Time Use, Job Stress, and Perceived Effectiveness

Science.gov (United States)

Grissom, Jason A.; Loeb, Susanna; Mitani, Hajime

2015-01-01

Purpose: Time demands faced by school principals make principals' work increasingly difficult. Research outside education suggests that effective time management skills may help principals meet job demands, reduce job stress, and improve their performance. The purpose of this paper is to investigate these hypotheses. Design/methodology/approach:…

Principal Self-Efficacy, Teacher Perceptions of Principal Performance, and Teacher Job Satisfaction

Science.gov (United States)

Evans, Molly Lynn

2016-01-01

In public schools, the principal's role is of paramount importance in influencing teachers to excel and to keep their job satisfaction high. The self-efficacy of leaders is an important characteristic of leadership, but this issue has not been extensively explored in school principals. Using internet-based questionnaires, this study obtained…

Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa.

Science.gov (United States)

M'bondoukwé, Noé Patrick; Kendjo, Eric; Mawili-Mboumba, Denise Patricia; Koumba Lengongo, Jeanne Vanessa; Offouga Mbouoronde, Christelle; Nkoghe, Dieudonné; Touré, Fousseyni; Bouyou-Akotet, Marielle Karine

2018-01-30

Malaria, filariasis, and intestinal parasitic infections (IPIs) are common and frequently overlap in developing countries. The prevalence and predictors of these infections were investigated in three different settlements (rural, semi-urban, and urban) of Gabon. During cross-sectional surveys performed from September 2013 to June 2014, 451 individuals were interviewed. In addition, blood and stool samples were analysed for the presence of Plasmodium, filarial roundworm, intestinal protozoan, and helminth infections. Intestinal parasitic infections (61.1%), including intestinal protozoa (56.7%) and soil-transmitted helminths (STHs) (22.2%), predominated, whereas Plasmodium falciparum (18.8%), Loa loa (4.7%), and Mansonella perstans (1.1%) were less prevalent. Filariasis and STHs were mainly found in rural settlements, whereas a higher plasmodial infection prevalence rate was observed in the periurban area. The most common IPI was blastocystosis (48.6%), followed by ascaridiasis (13.7%), trichuriasis (11.8%), amoebiasis (9.3%), giardiasis (4.8%), and strongyloidiasis (3.7%). Hookworm was detected in one adult from rural Dienga. Adults had a higher prevalence of Blastocystis hominis and STHs, whereas Giardia duodenalis was more frequently observed among children aged below 5 years (P < 0.01). The polyparasitism rate was 41.5%, with 7.0% Plasmodium-IPIs and 1.8% Plasmodium-STH co-infections. The multivariate analysis showed that living in a suburban area, belonging to the age group of 5-15 years, having none or a secondary education, or having an open body water close to home were significant risk factors for malaria (P ≤ 0.01). For STH infections, identified risk factors were drinking untreated water and living in a rural area (P ≤ 0.04). No significant predictors were identified for IPIs and malaria-IPI co-infection. This study reports a high prevalence of IPIs and intestinal protozoa, but a low rate of malaria-IPI co-infections in the study sites

Toxicity of seaweed-synthesized silver nanoparticles against the filariasis vector Culex quinquefasciatus and its impact on predation efficiency of the cyclopoid crustacean Mesocyclops longisetus.

Science.gov (United States)

Murugan, Kadarkarai; Benelli, Giovanni; Ayyappan, Suganya; Dinesh, Devakumar; Panneerselvam, Chellasamy; Nicoletti, Marcello; Hwang, Jiang-Shiou; Kumar, Palanisamy Mahesh; Subramaniam, Jayapal; Suresh, Udaiyan

2015-06-01

Nearly 1.4 billion people in 73 countries worldwide are threatened by lymphatic filariasis, a parasitic infection that leads to a disease commonly known as elephantiasis. Filariasis is vectored by mosquitoes, with special reference to the genus Culex. The main control tool against mosquito larvae is represented by treatments with organophosphates and insect growth regulators, with negative effects on human health and the environment. Recently, green-synthesized nanoparticles have been proposed as highly effective larvicidals against mosquito vectors. In this research, we attempted a reply to the following question: do green-synthesized nanoparticles affect predation rates of copepods against mosquito larvae? We proposed a novel method of seaweed-mediated synthesis of silver nanoparticles using the frond extract of Caulerpa scalpelliformis. The toxicity of the seaweed extract and silver nanoparticles was assessed against the filarial vector Culex quinquefasciatus. Then, we evaluated the predatory efficiency of the cyclopoid crustacean Mesocyclops longisetus against larval instars of C. quinquefasciatus in a nanoparticle-contaminated water environment. Green-synthesized silver nanoparticles were characterized by UV-vis spectrum, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). In mosquitocidal assays, the LC₅₀ values of the C. scalpelliformis extract against C. quinquefasciatus were 31.38 ppm (I), 46.49 ppm (II), 75.79 ppm (III), 102.26 ppm (IV), and 138.89 ppm (pupa), while LC₅₀ of silver nanoparticles were 3.08 ppm, (I), 3.49 ppm (II), 4.64 ppm (III), 5.86 ppm (IV), and 7.33 ppm (pupa). The predatory efficiency of the copepod M. longisetus in the control treatment was 78 and 59% against I and II instar larvae of C. quinquefasciatus. In a nanoparticle-contaminated environment, predation efficiency was 84 and 63%, respectively. Predation was higher against first instar larvae over other instars

Legal Problems of the Principal.

Science.gov (United States)

Stern, Ralph D.; And Others

The three talks included here treat aspects of the law--tort liability, student records, and the age of majority--as they relate to the principal. Specifically, the talk on torts deals with the consequences of principal negligence in the event of injuries to students. Assurance is given that a reasonable and prudent principal will have a minimum…

Principals Who Think Like Teachers

Science.gov (United States)

Fahey, Kevin

2013-01-01

Being a principal is a complex job, requiring quick, on-the-job learning. But many principals already have deep experience in a role at the very essence of the principalship. They know how to teach. In interviews with principals, Fahey and his colleagues learned that thinking like a teacher was key to their work. Part of thinking the way a teacher…

Trust Me, Principal, or Burn Out! The Relationship between Principals' Burnout and Trust in Students and Parents

Science.gov (United States)

Ozer, Niyazi

2013-01-01

The purpose of this study was to determine the primary school principals' views on trust in students and parents and also, to explore the relationships between principals' levels of professional burnout and their trust in students and parents. To this end, Principal Trust Survey and Friedman Principal Burnout scales were administered on 119…

Principal component regression analysis with SPSS.

Science.gov (United States)

Liu, R X; Kuang, J; Gong, Q; Hou, X L

2003-06-01

The paper introduces all indices of multicollinearity diagnoses, the basic principle of principal component regression and determination of 'best' equation method. The paper uses an example to describe how to do principal component regression analysis with SPSS 10.0: including all calculating processes of the principal component regression and all operations of linear regression, factor analysis, descriptives, compute variable and bivariate correlations procedures in SPSS 10.0. The principal component regression analysis can be used to overcome disturbance of the multicollinearity. The simplified, speeded up and accurate statistical effect is reached through the principal component regression analysis with SPSS.

Exploring the Impact of Applicants' Gender and Religion on Principals' Screening Decisions for Assistant Principal Applicants

Science.gov (United States)

Bon, Susan C.

2009-01-01

In this experimental study, a national random sample of high school principals (stratified by gender) were asked to evaluate hypothetical applicants whose resumes varied by religion (Jewish, Catholic, nondenominational) and gender (male, female) for employment as assistant principals. Results reveal that male principals rate all applicants higher…

Mosquito repellent properties of Delonix elata (L. gamble (Family: Fabaceae against filariasis vector, Culex quinquefasciatus Say. (Diptera: Culicidae

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Marimuthu Govindarajan

2014-02-01

Full Text Available Objective: To determine the repellent activity of hexane, ethyl acetate, benzene, chloroform and methanol extract of Delonix elata (D. elata leaf and seed against Culex quinquefasciatus (Cx. quinquefasciatus. Methods: Evaluation was carried out in a net cage (45 cm伊30 cm伊25 cm containing 100 blood starved female mosquitoes of Cx. quinquefasciatus. Repellent activity was carried out in the laboratory conditions according to the WHO 2009 protocol. Plant crude extracts of D. elata were applied at 1.0, 2.5, and 5.0 mg/cm2 separately in the exposed fore arm of study subjects. Ethanol was used as the sole control. Results: In this study, the applied plant crude extracts were observed to protect against mosquito bites. There were no allergic reactions experienced by the study subjects. The repellent activity of the extract was dependent on the strength of the extract. Among the tested solvents, the leaf and seed methanol extract showed the maximum efficacy. The highest concentration of 5.0 mg/cm2 provided over 150 min and 120 min protection, respectively. Conclusions: Crude extracts of D. elata exhibit the potential for controlling Cx. quinquefasciatus, the mosquito vector of filariasis.

Principals' Perceptions of Politics

Science.gov (United States)

Tooms, Autumn K.; Kretovics, Mark A.; Smialek, Charles A.

2007-01-01

This study is an effort to examine principals' perceptions of workplace politics and its influence on their productivity and efficacy. A survey was used to explore the perceptions of current school administrators with regard to workplace politics. The instrument was disseminated to principals serving public schools in one Midwestern state in the…

Urbanização, favelas e endemias: a produção da filariose no Recife, Brasil Urbanization, slums, and endemics: the production of filariasis in Recife, Brazil

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Maria de Fátima P. M. Albuquerque

1993-12-01

Full Text Available Neste artigo discutimos a ocorrência da filariose como um problema de saúde pública na cidade do Recife, capital do Estado de Pernambuco, que apresenta ainda hoje, em algumas áreas, níveis de prevalência preocupantes. Procura-se mostrar o papel da evolução urbana da cidade, caracterizada por um crescimento desordenado e pela formação de um número crescente de favelas, na criação de condições propícias para a transmissão desta parasitose. Identificamos categorias de análise, ligadas à organização social do espaço urbano, que devem ser incluídas como "mediadoras" em um modelo compreensivo da transmissão da filariose. Os aglomerados de habitações inadequadas, construídas em favelas superpovoadas, sem saneamento básico e sem sistema de drenagem de águas, propiciam as condições adequadas à proliferação dos mosquitos vetores da infecção e à manutenção da endemia.In this article the filariasis endemic is discussed as a public health problem in the city of Recife, capital of the state of Pernambuco, Brazil. Prevalence figures for this parasitic disease in some urban settings are cause for concern. The urban development process, characterized by disordered growth of cities and an increase in the number of slums, is pointed out as an important factor for the maintenance of conditions favouring disease transmission. Some analytical categories linked to urban social organization are identified and included in a comprehensive filariasis transmission model. Clusters of inadequate houses built in overcrowded slums without basic sanitation or a proper drainage system produce adequate conditions for proliferation of infection vectors and maintenance of the endemic.

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.

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Christina A Bulman

2015-02-01

Full Text Available Two major human diseases caused by filariid nematodes are onchocerciasis, or river blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, diethylcarbamazine (DEC, and albendazole are used in control programs for these diseases, but are mainly effective against the microfilarial stage and have minimal or no effect on adult worms. Adult Onchocerca volvulus and Brugia malayi worms (macrofilariae can live for up to 15 years, reproducing and allowing the infection to persist in a population. Therefore, to support control or elimination of these two diseases, effective macrofilaricidal drugs are necessary, in addition to current drugs. In an effort to identify macrofilaricidal drugs, we screened an FDA-approved library with adult worms of Brugia spp. and Onchocerca ochengi, third-stage larvae (L3s of Onchocerca volvulus, and the microfilariae of both O. ochengi and Loa loa. We found that auranofin, a gold-containing drug used for rheumatoid arthritis, was effective in vitro in killing both Brugia spp. and O. ochengi adult worms and in inhibiting the molting of L3s of O. volvulus with IC50 values in the low micromolar to nanomolar range. Auranofin had an approximately 43-fold higher IC50 against the microfilariae of L. loa compared with the IC50 for adult female O. ochengi, which may be beneficial if used in areas where Onchocerca and Brugia are co-endemic with L. loa, to prevent severe adverse reactions to the drug-induced death of L. loa microfilariae. Further testing indicated that auranofin is also effective in reducing Brugia adult worm burden in infected gerbils and that auranofin may be targeting the thioredoxin reductase in this nematode.

Renewing the Principal Pipeline

Science.gov (United States)

Turnbull, Brenda J.

2015-01-01

The work principals do has always mattered, but as the demands of the job increase, it matters even more. Perhaps once they could maintain safety and order and call it a day, but no longer. Successful principals today must also lead instruction and nurture a productive learning community for students, teachers, and staff. They set the tone for the…

Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis.

Science.gov (United States)

Joseph, S K; Ramaswamy, K

2013-07-18

The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and protein or protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-protein) and 48% (BmHAT protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis. Copyright © 2013 Elsevier Ltd. All rights reserved.

Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis

Science.gov (United States)

Joseph, SK; Ramaswamy, K

2013-01-01

The multivalent vaccine BmHAT, consisting of the Brugia malayi infective larval (L3) antigens heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL), was shown to be protective in rodent models from our laboratory. We hypothesize that since these antigens were identified using protective antibodies from immune endemic normal individuals, the multivalent vaccine can be augmented by natural L3 infections providing protection to the vaccinated host. This hypothesis was tested using single dose of DNA and Protein or Protein alone of the BmHAT vaccination in gerbils followed by live trickle L3 infection as booster dose. Vaccine-induced protection in gerbils was determined by worm establishment, micropore chamber assay and by antibody dependant cell cytotoxicity (ADCC) assay. Results were compared with the traditional prime-boost vaccination regimen. Gerbils vaccinated with BmHAT and boosted with L3 trickle infection were protected 51% (BmHAT DNA-Protein) and 48% (BmHAT Protein) respectively. BmHAT vaccination plus L3 trickle booster generated significant titer of antigen-specific IgG antibodies comparable to the traditional prime boost vaccination approach. BmHAT vaccination plus L3 trickle booster also generated antigen-specific cells in the spleen of vaccinated animals and these cells secreted predominantly IFN-γ and IL-4 in response to the vaccine antigens. These studies thus show that single dose of BmHAT multivalent vaccination followed by L3 trickle booster infection can confer significant protection against lymphatic filariasis. PMID:23735679

Principal Ports

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Principal Ports are defined by port limits or US Army Corps of Engineers (USACE) projects, these exclude non-USACE projects not authorized for publication. The...

Perceptions of Beginning Public School Principals.

Science.gov (United States)

Lyons, James E.

1993-01-01

Summarizes a study to determine principal's perceptions of their competency in primary responsibility areas and their greatest challenges and frustrations. Beginning principals are challenged by delegating responsibilities and becoming familiar with the principal's role, the local school, and school operations. Their major frustrations are role…

Multiscale principal component analysis

International Nuclear Information System (INIS)

Akinduko, A A; Gorban, A N

2014-01-01

Principal component analysis (PCA) is an important tool in exploring data. The conventional approach to PCA leads to a solution which favours the structures with large variances. This is sensitive to outliers and could obfuscate interesting underlying structures. One of the equivalent definitions of PCA is that it seeks the subspaces that maximize the sum of squared pairwise distances between data projections. This definition opens up more flexibility in the analysis of principal components which is useful in enhancing PCA. In this paper we introduce scales into PCA by maximizing only the sum of pairwise distances between projections for pairs of datapoints with distances within a chosen interval of values [l,u]. The resulting principal component decompositions in Multiscale PCA depend on point (l,u) on the plane and for each point we define projectors onto principal components. Cluster analysis of these projectors reveals the structures in the data at various scales. Each structure is described by the eigenvectors at the medoid point of the cluster which represent the structure. We also use the distortion of projections as a criterion for choosing an appropriate scale especially for data with outliers. This method was tested on both artificial distribution of data and real data. For data with multiscale structures, the method was able to reveal the different structures of the data and also to reduce the effect of outliers in the principal component analysis

Andragogical Practices of School Principals in Developing the Leadership Capacities of Assistant Principals

Science.gov (United States)

McDaniel, Luther

2017-01-01

The purpose of this mixed methods study was to assess school principals' perspectives of the extent to which they apply the principles of andragogy to the professional development of assistant principals in their schools. This study was conducted in school districts that constitute a RESA area in a southeastern state. The schools in these…

41 CFR 105-68.995 - Principal.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Principal. 105-68.995 Section 105-68.995 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 105-68.995 Principal. Principal means— (a...

Principal-Counselor Collaboration and School Climate

Science.gov (United States)

Rock, Wendy D.; Remley, Theodore P.; Range, Lillian M.

2017-01-01

Examining whether principal-counselor collaboration and school climate were related, researchers sent 4,193 surveys to high school counselors in the United States and received 419 responses. As principal-counselor collaboration increased, there were increases in counselors viewing the principal as supportive, the teachers as regarding one another…

12 CFR 561.39 - Principal office.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Principal office. 561.39 Section 561.39 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING ALL SAVINGS ASSOCIATIONS § 561.39 Principal office. The term principal office means the home...

Teacher Supervision Practices and Principals' Characteristics

Science.gov (United States)

April, Daniel; Bouchamma, Yamina

2015-01-01

A questionnaire was used to determine the individual and collective teacher supervision practices of school principals and vice-principals in Québec (n = 39) who participated in a research-action study on pedagogical supervision. These practices were then analyzed in terms of the principals' sociodemographic and socioprofessional characteristics…

Developing Principal Instructional Leadership through Collaborative Networking

Science.gov (United States)

Cone, Mariah Bahar

2010-01-01

This study examines what occurs when principals of urban schools meet together to learn and improve their instructional leadership in collaborative principal networks designed to support, sustain, and provide ongoing principal capacity building. Principal leadership is considered second only to teaching in its ability to improve schools, yet few…

Principal Stability and the Rural Divide

Science.gov (United States)

Pendola, Andrew; Fuller, Edward J.

2018-01-01

This article examines the unique features of the rural school context and how these features are associated with the stability of principals in these schools. Given the small but growing literature on the characteristics of rural principals, this study presents an exploratory analysis of principal stability across schools located in different…

A principal-agent Model of corruption

NARCIS (Netherlands)

Groenendijk, Nico

1997-01-01

One of the new avenues in the study of political corruption is that of neo-institutional economics, of which the principal-agent theory is a part. In this article a principal-agent model of corruption is presented, in which there are two principals (one of which is corrupting), and one agent (who is

Principal Curves on Riemannian Manifolds.

Science.gov (United States)

Hauberg, Soren

2016-09-01

Euclidean statistics are often generalized to Riemannian manifolds by replacing straight-line interpolations with geodesic ones. While these Riemannian models are familiar-looking, they are restricted by the inflexibility of geodesics, and they rely on constructions which are optimal only in Euclidean domains. We consider extensions of Principal Component Analysis (PCA) to Riemannian manifolds. Classic Riemannian approaches seek a geodesic curve passing through the mean that optimizes a criteria of interest. The requirements that the solution both is geodesic and must pass through the mean tend to imply that the methods only work well when the manifold is mostly flat within the support of the generating distribution. We argue that instead of generalizing linear Euclidean models, it is more fruitful to generalize non-linear Euclidean models. Specifically, we extend the classic Principal Curves from Hastie & Stuetzle to data residing on a complete Riemannian manifold. We show that for elliptical distributions in the tangent of spaces of constant curvature, the standard principal geodesic is a principal curve. The proposed model is simple to compute and avoids many of the pitfalls of traditional geodesic approaches. We empirically demonstrate the effectiveness of the Riemannian principal curves on several manifolds and datasets.

Principal Leadership for Technology-enhanced Learning in Science

Science.gov (United States)

Gerard, Libby F.; Bowyer, Jane B.; Linn, Marcia C.

2008-02-01

Reforms such as technology-enhanced instruction require principal leadership. Yet, many principals report that they need help to guide implementation of science and technology reforms. We identify strategies for helping principals provide this leadership. A two-phase design is employed. In the first phase we elicit principals' varied ideas about the Technology-enhanced Learning in Science (TELS) curriculum materials being implemented by teachers in their schools, and in the second phase we engage principals in a leadership workshop designed based on the ideas they generated. Analysis uses an emergent coding scheme to categorize principals' ideas, and a knowledge integration framework to capture the development of these ideas. The analysis suggests that principals frame their thinking about the implementation of TELS in terms of: principal leadership, curriculum, educational policy, teacher learning, student outcomes and financial resources. They seek to improve their own knowledge to support this reform. The principals organize their ideas around individual school goals and current political issues. Principals prefer professional development activities that engage them in reviewing curricula and student work with other principals. Based on the analysis, this study offers guidelines for creating learning opportunities that enhance principals' leadership abilities in technology and science reform.

Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil.

Science.gov (United States)

Cartaxo, Marina F S; Ayres, Constância F J; Weetman, David

2011-09-01

Recife is one of the largest cities in north-eastern Brazil and is endemic for lymphatic filariasis transmitted by Culex quinquefasciatus. Since 2003 a control program has targeted mosquito larvae by elimination of breeding sites and bimonthly application of Bacillus sphaericus. To assess the impact of this program on the local vector population we monitored the genetic diversity and differentiation of Cx. quinquefasciatus using microsatellites and a B. sphaericus-resistance associated mutation (cqm1(REC)) over a 3-year period. We detected a significant but gradual decline in allelic diversity, which, coupled with subtle temporal genetic structure, suggests a major impact of the control program on the vector population. Selection on cqm1(REC) does not appear to be involved with loss of neutral diversity from the population, with no temporal trend in resistant allele frequency and no correlation with microsatellite differentiation. The evidence for short-term genetic drift we detected suggests a low ratio of effective population size: census population size for Cx. quinquefasciatus, perhaps coupled with strong geographically-restricted population structure. Spatial definition of populations will be an important step for success of an expanded vector control program. Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Triangulating Principal Effectiveness: How Perspectives of Parents, Teachers, and Assistant Principals Identify the Central Importance of Managerial Skills. Working Paper 35

Science.gov (United States)

Grissom, Jason A.; Loeb, Susanna

2009-01-01

While the importance of effective principals is undisputed, few studies have addressed what specific skills principals need to promote school success. This study draws on unique data combining survey responses from principals, assistant principals, teachers and parents with rich administrative data to identify which principal skills matter most…

Principal components

NARCIS (Netherlands)

Hallin, M.; Hörmann, S.; Piegorsch, W.; El Shaarawi, A.

2012-01-01

Principal Components are probably the best known and most widely used of all multivariate analysis techniques. The essential idea consists in performing a linear transformation of the observed k-dimensional variables in such a way that the new variables are vectors of k mutually orthogonal

Measuring Principal Performance: How Rigorous Are Commonly Used Principal Performance Assessment Instruments? A Quality School Leadership Issue Brief

Science.gov (United States)

Condon, Christopher; Clifford, Matthew

2010-01-01

This brief reviews the publicly available principal assessments and points superintendents and policy makers toward strong instruments to measure principal performance. Specifically, the measures included in this review are expressly intended to evaluate principal performance and have varying degrees of publicly available evidence of psychometric…

Integration of irradiation with cytoplasmic incompatibility to facilitate a lymphatic filariasis vector elimination approach

Directory of Open Access Journals (Sweden)

Dobson Stephen L

2009-08-01

Full Text Available Abstract Background Mass drug administration (MDA is the emphasis of an ongoing global lymphatic filariasis (LF elimination program by the World Health Organization, in which the entire 'at risk' human population is treated annually with anti-filarial drugs. However, there is evidence that the MDA strategy may not be equally appropriate in all areas of LF transmission, leading to calls for the augmentation of MDA with anti-vector interventions. One potential augmentative intervention is the elimination of vectors via repeated inundative releases of male mosquitoes made cytoplasmically incompatible via an infection with Wolbachia bacteria. However, with a reduction in the vector population size, there is the risk that an accidental female release would permit the establishment of the incompatible Wolbachia infection type, resulting in population replacement instead of population elimination. To avoid the release of fertile females, we propose the exposure of release individuals to low doses of radiation to sterilize any accidentally released females, reducing the risk of population replacement. Results Aedes polynesiensis pupae of differing ages were irradiated to determine a radiation dose that results in sterility but that does not affect the survival and competitiveness of males. Laboratory assays demonstrate that males irradiated at a female sterilizing dosage of 40 Gy are equally competitive with un-irradiated males. No effect of irradiation on the ability of Wolbachia to affect egg hatch was observed. Conclusion An irradiation dose of 40 Gy is sufficient to cause female sterility, but has no observed negative effect on male fitness. The results support further development of this approach as a preventative measure against accidental population replacement.

The global programme to eliminate lymphatic filariasis: health impact after 8 years.

Directory of Open Access Journals (Sweden)

Eric A Ottesen

Full Text Available BACKGROUND: In its first 8 years, the Global Programme to Eliminate Lymphatic Filariasis (GPELF achieved an unprecedentedly rapid scale-up: >1.9 billion treatments with anti-filarial drugs (albendazole, ivermectin, and diethylcarbamazine were provided via yearly mass drug administration (MDA to a minimum of 570 million individuals living in 48 of the 83 initially identified LF-endemic countries. METHODOLOGY: To assess the health impact that this massive global effort has had, we analyzed the benefits accrued first from preventing or stopping the progression of LF disease, and then from the broader anti-parasite effects ('beyond-LF' benefits attributable to the use of albendazole and ivermectin. Projections were based on demographic and disease prevalence data from publications of the Population Reference Bureau, The World Bank, and the World Health Organization. RESULT: Between 2000 and 2007, the GPELF prevented LF disease in an estimated 6.6 million newborns who would otherwise have acquired LF, thus averting in their lifetimes nearly 1.4 million cases of hydrocele, 800,000 cases of lymphedema and 4.4 million cases of subclinical disease. Similarly, 9.5 million individuals--previously infected but without overt manifestations of disease--were protected from developing hydrocele (6.0 million or lymphedema (3.5 million. These LF-related benefits, by themselves, translate into 32 million DALYs (Disability Adjusted Life Years averted. Ancillary, 'beyond-LF' benefits from the >1.9 billion treatments delivered by the GPELF were also enormous, especially because of the >310 million treatments to the children and women of childbearing age who received albendazole with/without ivermectin (effectively treating intestinal helminths, onchocerciasis, lice, scabies, and other conditions. These benefits can be described but remain difficult to quantify, largely because of the poorly defined epidemiology of these latter infections. CONCLUSION: The GPELF has

Innovation Management Perceptions of Principals

Science.gov (United States)

Bakir, Asli Agiroglu

2016-01-01

This study is aimed to determine the perceptions of principals about innovation management and to investigate whether there is a significant difference in this perception according to various parameters. In the study, descriptive research model is used and universe is consisted from principals who participated in "Acquiring Formation Course…

Time Management for New Principals

Science.gov (United States)

Ruder, Robert

2008-01-01

Becoming a principal is a milestone in an educator's professional life. The principalship is an opportunity to provide leadership that will afford students opportunities to thrive in a nurturing and supportive environment. Despite the continuously expanding demands of being a new principal, effective time management will enable an individual to be…

Urban lymphatic filariasis in the metropolis of Dar es Salaam, Tanzania.

Science.gov (United States)

Mwakitalu, Mbutolwe E; Malecela, Mwelecele N; Pedersen, Erling M; Mosha, Franklin W; Simonsen, Paul E

2013-09-30

The last decades have seen a considerable increase in urbanization in Sub-Saharan Africa, and it is estimated that over 50% of the population will live in urban areas by 2040. Rapid growth of cities combined with limited economic resources often result in informal settlements and slums with favorable conditions for proliferation of vectors of lymphatic filariasis (LF). In Dar es Salaam, which has grown more than 30 times in population during the past 55 years (4.4 million inhabitants in 2012), previous surveys have indicated high prevalences of LF. This study investigated epidemiological aspects of LF in Dar es Salaam, as a background for planning and implementation of control. Six sites with varying distance from the city center (3-30 km) and covering different population densities, socioeconomic characteristics, and water, sewerage and sanitary facilities were selected for the study. Pupils from one public primary school at each site were screened for circulating filarial antigen (CFA; marker of adult worm infection) and antibodies to Bm14 (marker of exposure to transmission). Community members were examined for CFA, microfilariae and chronic manifestations. Structured questionnaires were administered to pupils and heads of community households, and vector surveys were carried out in selected households. The study indicated that a tremendous decrease in the burden of LF infection had occurred, despite haphazard urbanisation. Contributing factors may be urban malaria control targeting Anopheles vectors, short survival time of the numerous Culex quinquefasciatus vectors in the urban environment, widespread use of bed nets and other mosquito proofing measures, and mass drug administration (MDA) in 2006 and 2007. Although the level of ongoing transmission was low, the burden of chronic LF disease was still high. The development has so far been promising, but continued efforts are necessary to ensure elimination of LF as a public health problem. These will include

What Motivates Principals?

Science.gov (United States)

Iannone, Ron

1973-01-01

Achievement and recognition were mentioned as factors appearing with greater frequency in principal's job satisfactions; school district policy and interpersonal relations were mentioned as job dissatisfactions. (Editor)

Bureaucratic Control and Principal Role.

Science.gov (United States)

Bezdek, Robert; And Others

The purposes of this study were to determine the manner in which the imposition of increased bureaucratic control over principals influenced their allocation of time to tasks and to investigate principals' perceptions of the changes in their roles brought about by this increased control. The specific bureaucratic control system whose effects were…

A Mathematical Model to Investigate the Long-Term Effects of the Lymphatic Filariasis Medical Treatment in Jati Sampurna, West Java

Directory of Open Access Journals (Sweden)

A.K. Supriatna

2009-03-01

Full Text Available In this paper we discuss a mathematical model for the transmission of Lymphatic Filariasis disease in Jati Sampurna, West Java Indonesia. The model assumes that acute infected humans are infectious and treatment is given to a certain number of acute infected humans found from screening process. The treated acute individuals are assumed to be remain susceptible to the disease. The model is analyzed and it is found a condition for the existence and stability of the endemic equilibrium. A well known rule of thumb in epidemiological model, that is, the endemic equilibrium exists and stable if the basic reproduction number is greater than one, is shown. Moreover, it is also shown that if the level of screening n is sufficiently large, current medical treatment strategy will be able to reduce the long-term level of incidences. However, in practice it is not realistic and cannot eliminate the disease, in terms of reducing the basic reproduction number. The reproduction number can be reduced by giving additional treatments, such as reducing the biting rate and mosquito's density. This suggests that there should be a combination of treatment to eliminate the disease.

School Principals' Sources of Knowledge

Science.gov (United States)

Perkins, Arland Early

2014-01-01

The purpose of this study was to determine what sources of professional knowledge are available to principals in 1 rural East Tennessee school district. Qualitative research methods were applied to gain an understanding of what sources of knowledge are used by school principals in 1 rural East Tennessee school district and the barriers they face…

Reduction of symplectic principal R-bundles

International Nuclear Information System (INIS)

Lacirasella, Ignazio; Marrero, Juan Carlos; Padrón, Edith

2012-01-01

We describe a reduction process for symplectic principal R-bundles in the presence of a momentum map. These types of structures play an important role in the geometric formulation of non-autonomous Hamiltonian systems. We apply this procedure to the standard symplectic principal R-bundle associated with a fibration π:M→R. Moreover, we show a reduction process for non-autonomous Hamiltonian systems on symplectic principal R-bundles. We apply these reduction processes to several examples. (paper)

New Principal Coaching as a Safety Net

Science.gov (United States)

Celoria, Davide; Roberson, Ingrid

2015-01-01

This study examines new principal coaching as an induction process and explores the emotional dimensions of educational leadership. Twelve principal coaches and new principals--six of each--participated in this qualitative study that employed emergent coding (Creswell, 2008; Denzin, 2005; Glaser & Strauss, 1998; Spradley, 1979). The major…

Modelling Monthly Mental Sickness Cases Using Principal ...

African Journals Online (AJOL)

The methodology was principal component analysis (PCA) using data obtained from the hospital to estimate regression coefficients and parameters. It was found that the principal component regression model that was derived was good predictive tool. The principal component regression model obtained was okay and this ...

Importance of an Effective Principal-Counselor Relationship

Science.gov (United States)

Edwards, LaWanda; Grace, Ronald; King, Gwendolyn

2014-01-01

An effective relationship between the principal and school counselor is essential when improving student achievement. To have an effective relationship, there must be communication, trust and respect, leadership, and collaborative planning between the principal and school counselor (College Board, 2011). Principals and school counselors are both…

Management Of Indiscipline Among Teachers By Principals Of ...

African Journals Online (AJOL)

This study compared the management of indiscipline among teachers by public and private school principals in Akwa Ibom State. The sample comprised four hundred and fifty (450) principals/vice principals randomly selected from a population of one thousand, four hundred and twenty eight (1,428) principals. The null ...

What Do Effective Principals Do?

Science.gov (United States)

Protheroe, Nancy

2011-01-01

Much has been written during the past decade about the changing role of the principal and the shift in emphasis from manager to instructional leader. Anyone in education, and especially principals themselves, could develop a mental list of responsibilities that fit within each of these realms. But research makes it clear that both those aspects of…

The Principal as Academician: The Renewed Voice.

Science.gov (United States)

McAvoy, Brenda, Ed.

This collection of essays was written by principals who participated in the 1986-87 Humanities Seminar sponsored by the Principals' Institute of Georgia State University. The focus was "The Evolution of Intellectual Leadership." The roles of the principal as philosopher, historian, ethnician, writer and team member are examined through…

Leadership Coaching for Principals: A National Study

Science.gov (United States)

Wise, Donald; Cavazos, Blanca

2017-01-01

Surveys were sent to a large representative sample of public school principals in the United States asking if they had received leadership coaching. Comparison of responses to actual numbers of principals indicates that the sample represents the first national study of principal leadership coaching. Results indicate that approximately 50% of all…

Riccati transformations and principal solutions of discrete linear systems

International Nuclear Information System (INIS)

Ahlbrandt, C.D.; Hooker, J.W.

1984-01-01

Consider a second-order linear matrix difference equation. A definition of principal and anti-principal, or recessive and dominant, solutions of the equation are given and the existence of principal and anti-principal solutions and the essential uniqueness of principal solutions is proven

Principals' Collaborative Roles as Leaders for Learning

Science.gov (United States)

Kitchen, Margaret; Gray, Susan; Jeurissen, Maree

2016-01-01

This article draws on data from three multicultural New Zealand primary schools to reconceptualize principals' roles as leaders for learning. In doing so, the writers build on Sinnema and Robinson's (2012) article on goal setting in principal evaluation. Sinnema and Robinson found that even principals hand-picked for their experience fell short on…

Principals as Assessment Leaders in Rural Schools

Science.gov (United States)

Renihan, Patrick; Noonan, Brian

2012-01-01

This article reports a study of rural school principals' assessment leadership roles and the impact of rural context on their work. The study involved three focus groups of principals serving small rural schools of varied size and grade configuration in three systems. Principals viewed assessment as a matter of teacher accountability and as a…

Principals: Learn P.R. Survival Skills.

Science.gov (United States)

Reep, Beverly B.

1988-01-01

School building level public relations depends on the principal or vice principal. Strategies designed to enhance school public relations programs include linking school and community, working with the press, and keeping morale high inside the school. (MLF)

Principal minors and rhombus tilings

International Nuclear Information System (INIS)

Kenyon, Richard; Pemantle, Robin

2014-01-01

The algebraic relations between the principal minors of a generic n × n matrix are somewhat mysterious, see e.g. Lin and Sturmfels (2009 J. Algebra 322 4121–31). We show, however, that by adding in certain almost principal minors, the ideal of relations is generated by translations of a single relation, the so-called hexahedron relation, which is a composition of six cluster mutations. We give in particular a Laurent-polynomial parameterization of the space of n × n matrices, whose parameters consist of certain principal and almost principal minors. The parameters naturally live on vertices and faces of the tiles in a rhombus tiling of a convex 2n-gon. A matrix is associated to an equivalence class of tilings, all related to each other by Yang–Baxter-like transformations. By specializing the initial data we can similarly parameterize the space of Hermitian symmetric matrices over R,C or H the quaternions. Moreover by further specialization we can parametrize the space of positive definite matrices over these rings. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Cluster algebras mathematical physics’. (paper)

Statewide Data on Supply and Demand of Principals after Policy Changes to Principal Preparation in Illinois

Science.gov (United States)

Haller, Alicia; Hunt, Erika

2016-01-01

Research has demonstrated that principals have a powerful impact on school improvement and student learning. Principals play a vital role in recruiting, developing, and retaining effective teachers; creating a school-wide culture of learning; and implementing a continuous improvement plan aimed at increasing student achievement. Leithwood, Louis,…

Secondary mapping of lymphatic filariasis in Haiti-definition of transmission foci in low-prevalence settings.

Directory of Open Access Journals (Sweden)

Naomi Drexler

Full Text Available To eliminate Lymphatic filariasis (LF as a public health problem, the World Health Organization (WHO recommends that any area with infection prevalence greater than or equal to 1% (denoted by presence of microfilaremia or antigenemia should receive mass drug administration (MDA of antifilarial drugs for at least five consecutive rounds. Areas of low-antigen prevalence (< 1% are thought to pose little risk for continued transmission of LF. Five low-antigen prevalence communes in Haiti, characterized as part of a national survey, were further assessed for transmission in this study. An initial evaluation of schoolchildren was performed in each commune to identify antigen-positive children who served as index cases for subsequent community surveys conducted among households neighboring the index cases. Global positioning system (GPS coordinates and immunochromatographic tests (ICT for filarial antigenemia were collected on approximately 1,600 persons of all ages in the five communes. The relationship between antigen-positive cases in the community and distance from index cases was evaluated using multivariate regression techniques and analyses of spatial clustering. Community surveys demonstrated higher antigen prevalence in three of the five communes than was observed in the original mapping survey; autochthonous cases were found in the same three communes. Regression techniques identified a significantly increased likelihood of being antigen-positive when living within 20 meters of index cases when controlling for age, gender, and commune. Spatial clustering of antigen-positive cases was observed in some, but not all communes. Our results suggest that localized transmission was present even in low-prevalence settings and suggest that better surveillance methods may be needed to detect microfoci of LF transmission.

The Deputy Principal Instructional Leadership Role and Professional Learning: Perceptions of Secondary Principals, Deputies and Teachers

Science.gov (United States)

Leaf, Ann; Odhiambo, George

2017-01-01

Purpose: The purpose of this paper is to report on a study examining the perceptions of secondary principals, deputies and teachers, of deputy principal (DP) instructional leadership (IL), as well as deputies' professional learning (PL) needs. Framed within an interpretivist approach, the specific objectives of this study were: to explore the…

Measuring Principals' Effectiveness: Results from New Jersey's First Year of Statewide Principal Evaluation. REL 2016-156

Science.gov (United States)

Herrmann, Mariesa; Ross, Christine

2016-01-01

States and districts across the country are implementing new principal evaluation systems that include measures of the quality of principals' school leadership practices and measures of student achievement growth. Because these evaluation systems will be used for high-stakes decisions, it is important that the component measures of the evaluation…

Principals' Perceptions of School Public Relations

Science.gov (United States)

Morris, Robert C.; Chan, Tak Cheung; Patterson, Judith

2009-01-01

This study was designed to investigate school principals' perceptions on school public relations in five areas: community demographics, parental involvement, internal and external communications, school council issues, and community resources. Findings indicated that principals' concerns were as follows: rapid population growth, change of…

Principal-vector-directed fringe-tracking technique.

Science.gov (United States)

Zhang, Zhihui; Guo, Hongwei

2014-11-01

Fringe tracking is one of the most straightforward techniques for analyzing a single fringe pattern. This work presents a principal-vector-directed fringe-tracking technique. It uses Gaussian derivatives for estimating fringe gradients and uses hysteresis thresholding for segmenting singular points, thus improving the principal component analysis method. Using it allows us to estimate the principal vectors of fringes from a pattern with high noise. The fringe-tracking procedure is directed by these principal vectors, so that erroneous results induced by noise and other error-inducing factors are avoided. At the same time, the singular point regions of the fringe pattern are identified automatically. Using them allows us to determine paths through which the "seed" point for each fringe skeleton is easy to find, thus alleviating the computational burden in processing the fringe pattern. The results of a numerical simulation and experiment demonstrate this method to be valid.

Whose Perception of Principal Instructional Leadership? Principal-Teacher Perceptual (Dis)agreement and Its Influence on Teacher Collaboration

Science.gov (United States)

Park, Joo-Ho; Ham, Seung-Hwan

2016-01-01

This study examines teacher collaboration across three Asia-Pacific countries (Australia, Malaysia, and South Korea), focusing on the possibility that principal-teacher perceptual disagreement regarding principal instructional leadership performance may impede progress toward a school organizational condition conducive to collaborative teacher…

Elimination of lymphatic filariasis as a public health problem from the Cook Islands.

Science.gov (United States)

Ave, Charlie; Kapa, D Ramaiah; Ottesen, Eric

2018-01-01

The Cook Islands has a long history of high-endemicity lymphatic filariasis (LF) transmitted by Aedes vector mosquitoes. Though the infection prevalence had declined between 1975 and 1999 following episodic treatment activities, still infection was widespread with pockets of persistent infection. Beginning in 1999, the Cook Islands embarked on a national program, in partnership with Pacific Programme to Eliminate LF (PacELF), to eliminate LF as a public health problem. All 12 inhabited islands were identified as endemic, and six rounds of mass drug administration (MDA) with once-yearly, single-dose albendazole plus diethylcarbamazine (DEC) were implemented during 2000-2006 to interrupt transmission of LF. Surveys carried out at the baseline, mid-term, stop-MDA, and post-MDA periods assessed LF antigen (Ag) prevalence in children and adults. Historical data, health workers' observations, and hospital records were used to assess the trend and burden of chronic disease. The baseline Ag prevalence (1999) ranged from 2.0% in Manihiki to > 18.0% in Aitutaki, Mitiaro, and Pukapuka, and the national average Ag prevalence was 8.6%. MDA, carried out with a national treatment coverage over six annual rounds of MDA ranging from 63.5 to 96.7% in different years, was stopped in 2007. By then, the national Ag prevalence had declined to 0.27%. The post-MDA surveillance survey results (2013-2014) showed that Ag prevalence had fallen to 0% in 11/12 islands, and the national prevalence was only 0.03%. Chronic filarial disease had almost entirely disappeared. The Cook Islands met all the criteria required for the World Health Organization (WHO) to acknowledge elimination of LF as a public health problem, as it did officially in 2016. This success also confirms that LF, even when transmitted by Aedes mosquitoes that are recognized to be more efficient than other vector species, can be eliminated as a public health problem by six rounds of MDA.

New pulser for principal PO power

International Nuclear Information System (INIS)

Coudert, G.

1984-01-01

The pulser of the principal power of the PS is the unit that makes it possible to generate the reference function of the voltage of the principal magnet. This function depends on time and on the magnetic field of the magnet. It also generates various synchronization and reference pulses

An Examination of Principal Job Satisfaction

Science.gov (United States)

Pengilly, Michelle M.

2010-01-01

As education continues to succumb to deficits in budgets and increasingly high levels of student performance to meet the federal and state mandates, the quest to sustain and retain successful principals is imperative. The National Association of School Boards (1999) portrays effective principals as "linchpins" of school improvement and…

The Succession of a School Principal.

Science.gov (United States)

Fauske, Janice R.; Ogawa, Rodney T.

Applying theory from organizational and cultural perspectives to succession of principals, this study observes and records the language and culture of a small suburban elementary school. The study's procedures included analyses of shared organizational understandings as well as identification of the principal's influence on the school. Analyses of…

Social Media Strategies for School Principals

Science.gov (United States)

Cox, Dan; McLeod, Scott

2014-01-01

The purpose of this qualitative study was to describe, analyze, and interpret the experiences of school principals who use multiple social media tools with stakeholders as part of their comprehensive communications practices. Additionally, it examined why school principals have chosen to communicate with their stakeholders through social media.…

The Interdependence of Principal School Leadership and Student Achievement

Science.gov (United States)

Soehner, David; Ryan, Thomas

2011-01-01

This review illuminated principal school leadership as a variable that impacted achievement. The principal as school leader and manager was explored because these roles were thought to impact student achievement both directly and indirectly. Specific principal leadership behaviors and principal effectiveness were explored as variables potentially…

District Leadership for Effective Principal Evaluation and Support

Science.gov (United States)

Kimball, Steven M.; Arrigoni, Jessica; Clifford, Matthew; Yoder, Maureen; Milanowski, Anthony

2015-01-01

Research demonstrating principals' impact on student learning outcomes has fueled the shift from principals as facilities managers to an emphasis on instructional leadership (Hallinger & Heck, 1996; Leithwood, Louis, Anderson, & Wahlstrom, 2004; Marzano, Waters, & McNulty, 2005). Principals are under increasing pressure to carry out…

School Restructuring and the Dilemmas of Principals' Work.

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Wildy, Helen; Louden, William

2000-01-01

The complexity of principals' work may be characterized according to three dilemmas: accountability, autonomy, and efficiency. Narrative vignettes of 74 Australian principals revealed that principals were fair and inclusive. When faced with restructuring dilemmas, however, they favored strong over shared leadership, efficiency over collaboration,…

Do Principals Fire the Worst Teachers?

Science.gov (United States)

Jacob, Brian A.

2011-01-01

This article takes advantage of a unique policy change to examine how principals make decisions regarding teacher dismissal. In 2004, the Chicago Public Schools (CPS) and Chicago Teachers Union signed a new collective bargaining agreement that gave principals the flexibility to dismiss probationary teachers for any reason and without the…

Revising the Role of Principal Supervisor

Science.gov (United States)

Saltzman, Amy

2016-01-01

In Washington, D.C., and Tulsa, Okla., districts whose efforts are supported by the Wallace Foundation, principal supervisors concentrate on bolstering their principals' work to improve instruction, as opposed to focusing on the managerial or operational aspects of running a school. Supervisors oversee fewer schools, which enables them to provide…

The Principal's Guide to Grant Success.

Science.gov (United States)

Bauer, David G.

This book provides principals of public and private elementary and middle schools with a step-by-step approach for developing a system that empowers faculty, staff, and the school community in attracting grant funds. Following the introduction, chapter 1 discusses the principal's role in supporting grantseeking. Chapter 2 describes how to…

Principals, agents and research programmes

OpenAIRE

Elizabeth Shove

2003-01-01

Research programmes appear to represent one of the more powerful instruments through which research funders (principals) steer and shape what researchers (agents) do. The fact that agents navigate between different sources and styles of programme funding and that they use programmes to their own ends is readily accommodated within principal-agent theory with the help of concepts such as shirking and defection. Taking a different route, I use three examples of research programming (by the UK, ...

Negligence--When Is the Principal Liable? A Legal Memorandum.

Science.gov (United States)

Stern, Ralph D., Ed.

Negligence, a tort liability, is defined, discussed, and reviewed in relation to several court decisions involving school principals. The history of liability suits against school principals suggests that a reasonable, prudent principal can avoid legal problems. Ten guidelines are presented to assist principals in avoiding charges of negligence.…

The Principal and the Law. Elementary Principal Series No. 7.

Science.gov (United States)

Doverspike, David E.; Cone, W. Henry

Developments over the past 25 years in school-related legal issues in elementary schools have significantly changed the principal's role. In 1975, a decision of the U.S. Supreme Court established three due-process guidelines for short-term suspension. The decision requires student notification of charges, explanation of evidence, and an informal…

Should Principals Know More about Law?

Science.gov (United States)

Doctor, Tyrus L.

2013-01-01

Educational law is a critical piece of the education conundrum. Principals reference law books on a daily basis in order to address the wide range of complex problems in the school system. A principal's knowledge of law issues and legal decision-making are essential to provide effective feedback for a successful school.

[Lymphatic filariasis transmission assessment survey in schools three years after stopping mass drug treatment with albendazole and ivermectin in the 7 endemic districts in Togo].

Science.gov (United States)

Dorkenoo, A M; Sodahlon, Y K; Bronzan, R N; Yakpa, K; Sossou, E; Ouro-Medeli, A; Teko, M; Seim, A; Mathieu, E

2015-08-01

The aim of this study is to verify the level of transmission of lymphatic filariasis three years after stopping mass drug treatment in the 7 endemic districts in Togo. The survey was conducted in 2012 in Togo's 7 endemic districts grouped into four evaluation units (EU) using the WHO-recommended transmission assessment survey (TAS) protocol. Children aged 6-7 years were screened for Wuchereria bancofti antigen using the immunochromatographic card (ICT) method. A cluster sampling method was used to select eligible children in schools as the net primary-school enrolment ratio is greater than or equal to 75% in each of the four EUs. The number of children and schools to be selected in each EU, the randomization list for the selection of these children and the critical cut-off number of positive cases not to exceed were automatically generated using the Survey Sample Builder (SSB) tool, (NTD Support Center, Atlanta, Ga, USA). For confirmation, positive cases were subsequently tested for microfilaremia using nocturnal thick blood smear and for filarial antigen using Og4C3 antigen ELISA (TropBio ELISA Kit®, Townsville, Queensland, Australia). An EU is considered to have passed the test successfully (it is assumed that transmission can no longer be sustained), when the number of positive cases is below the critical cut-off number set by the SSB, which is roughly equivalent to 2% prevalence. Of the 1 706 children surveyed in Kpendjal-Tone's EU, 1 549 in Binah-Doufelgou's EU, 1 550 in Kozah's EU and the 1 575 in Amou-Haho's EU, 8 (0.46%), 1 (0.08%), 0 (0.00%) and 4 (0.25%) ICT positive cases respectively were detected. The number of positive ICT tests was well below 18, the critical cut number for each of the 4 EUs. All 13 ICT positive cases tested negative for nocturnal microfilaremia and Og4C3 ELISA. We conclude that all four EU passed the TAS with success, and the transmission of Wuchereria bancrofti is no longer likely to be sustained in the 7 endemic districts in Togo

Principal Ports and Facilities

Data.gov (United States)

California Natural Resource Agency — The Principal Port file contains USACE port codes, geographic locations (longitude, latitude), names, and commodity tonnage summaries (total tons, domestic, foreign,...

Principal Ports and Facilities

Data.gov (United States)

California Department of Resources — The Principal Port file contains USACE port codes, geographic locations (longitude, latitude), names, and commodity tonnage summaries (total tons, domestic, foreign,...

Promoting principals' managerial involvement in instructional improvement.

Science.gov (United States)

Gillat, A

1994-01-01

Studies of school leadership suggest that visiting classrooms, emphasizing achievement and training, and supporting teachers are important indicators of the effectiveness of school principals. The utility of a behavior-analytic program to support the enhancement of these behaviors in 2 school principals and the impact of their involvement upon teachers' and students' performances in three classes were examined in two experiments, one at an elementary school and another at a secondary school. Treatment conditions consisted of helping the principal or teacher to schedule his or her time and to use goal setting, feedback, and praise. A withdrawal design (Experiment 1) and a multiple baseline across classrooms (Experiment 2) showed that the principal's and teacher's rates of praise, feedback, and goal setting increased during the intervention, and were associated with improvements in the academic performance of the students. In the future, school psychologists might analyze the impact of involving themselves in supporting the principal's involvement in improving students' and teachers' performances or in playing a similar leadership role themselves.

Primary School Principals' Self-Monitoring Skills

Science.gov (United States)

Konan, Necdet

2015-01-01

The aim of the present study is to identify primary school principals' self-monitoring skills. The study adopted the general survey model and its population comprised primary school principals serving in the city of Diyarbakir, Turkey, while 292 of these constituted the sample. Self-Monitoring Scale was used as the data collection instrument. In…

How Not to Prepare School Principals

Science.gov (United States)

Davis, Stephen H.; Leon, Ronald J.

2011-01-01

Instead of focusing on how principals should be trained, an contrarian view is offered, grounded upon theoretical perspectives of experiential learning, and in particular, upon the theory of andragogy. A brief parable of the DoNoHarm School of Medicine is used as a descriptive analog for many principal preparation programs in America. The…

Evaluating the Effectiveness of Traditional and Alternative Principal Preparation Programs

Science.gov (United States)

Pannell, Summer; Peltier-Glaze, Bernnell M.; Haynes, Ingrid; Davis, Delilah; Skelton, Carrie

2015-01-01

This study sought to determine the effectiveness on increasing student achievement of principals trained in a traditional principal preparation program and those trained in an alternate route principal preparation program within the same Mississippi university. Sixty-six Mississippi principals and assistant principals participated in the study. Of…

Principal Turnover: Upheaval and Uncertainty in Charter Schools?

Science.gov (United States)

Ni, Yongmei; Sun, Min; Rorrer, Andrea

2015-01-01

Purpose: Informed by literature on labor market and school choice, this study aims to examine the dynamics of principal career movements in charter schools by comparing principal turnover rates and patterns between charter schools and traditional public schools. Research Methods/Approach: This study uses longitudinal data on Utah principals and…

Principal succession: The socialisation of a primary school principal in South Africa

Directory of Open Access Journals (Sweden)

Gertruida M. Steyn

2013-04-01

Full Text Available This study focussed on the socialisation of a new principal in a South African primary school with a strong Christian culture. He was appointed when the predecessor retired after more than two decades. The conceptual framework focuses on the three phases of socialisation: professional socialisation, organisational socialisation and occupational identity, which are used to interpret the study. A qualitative study, which occurred during two phases, investigated the phenomenon, principal succession, in the particular school. The data collection methods included a number of interviews with the principal, a focus group interview with staff members who experienced the previous principal’s leadership practice, and individual interviews with staff members. The following categories emerged from the data analysis: Recalling the previous principal: ‘One sees Mr X [the predecessor] everywhere’; Entry and orientation: ‘I found it intimidating initially’; and Immersion and reshaping: ‘Reins that previously were a bit slack, he is now pulling tight’.Die sosialisering van ’n primêre skoolhoof in Suid-Afrika. Hierdie studie het gefokus op die sosialisering van ’n nuwe skoolhoof in ’n Suid-Afrikaanse primêre skool met ’n sterk Christelike kultuur. Hy is aangestel toe sy voorganger ná meer as twee dekades afgetree het. Die konseptuele raamwerk, wat gebruik is om die bevindinge te interpreteer, het op die drie fases van sosialisering gefokus, naamlik professionele sosialisering, organisatoriese sosialisering en beroepsidentiteit. ’n Kwalitatiewe ondersoek na die skoolhoofopvolgingverskynsel in die bepaalde skool is in twee fases gedoen. Die data-insamelingsmetodes het ’n aantal onderhoude met die skoolhoof, ’n fokusgroeponderhoud met personeellede wat ook onder leierskap van die vorige skoolhoof gewerk het en individuele onderhoude met personeellede ingesluit. Tydens die data-analise het die volgende kategorieë na vore gekom

Looked after or Left Behind: The Effectiveness of Principal Preparation Programs as Perceived by Generation Y Principals

Science.gov (United States)

Sledge, Chandra

2013-01-01

This research study intended to discover the perceptions of 10 Illinois Generation Y novice high school principals pertaining to the effectiveness of their principal preparation programs in terms of how well it prepared them to lead in the first three years of their principalship, and what subsequent professional development they deemed necessary…

Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin.

Directory of Open Access Journals (Sweden)

Nana O Wilson

2016-12-01

Full Text Available In Africa, onchocerciasis and lymphatic filariasis (LF are co-endemic in many areas. Current efforts to eliminate both diseases are through ivermectin-based mass drug administration (MDA. Years of ivermectin distribution for onchocerciasis may have interrupted LF transmission in certain areas. The Kédougou region, Senegal, is co-endemic for LF and onchocerciasis. Though MDA for onchocerciasis started in 1988, in 2014 albendazole had not yet been added for LF. The objective of this study was to assess in an integrated manner the LF and onchocerciasis status in the three districts of the Kédougou region after ≥10 years of ivermectin-based MDA. The study employed an African Programme for Onchocerciasis Control (APOC onchocerciasis-related methodology. In the three districts, 14 villages close to three rivers that have Simulium damnosum breeding sites were surveyed. Convenience sampling of residents ≥5 years old was performed. Assessment for LF antigenemia by immunochromatographic testing (ICT was added to skin snip microscopy for onchocerciasis. Participants were also tested for antibodies against Wb123 (LF and Ov16 (onchocerciasis antigens. In two districts, no participants were ICT or skin snip positive. In the third district, 3.5% were ICT positive and 0.7% were skin snip positive. In all the three districts, Wb123 prevalence was 0.6%. Overall, Ov16 prevalence was 6.9%. Ov16 prevalence among children 5-9 years old in the study was 2.5%. LF antigenemia prevalence was still above treatment threshold in one district despite ≥10 years of ivermectin-based MDA. The presence of Ov16 positive children suggested recent transmission of Onchocerca volvulus. This study showed the feasibility of integrated evaluation of onchocerciasis and LF but development of integrated robust methods for assessing transmission of both LF and onchocerciasis are needed to determine where MDA can be stopped safely in co-endemic areas.

Stepping stones: Principal career paths and school outcomes.

Science.gov (United States)

Béteille, Tara; Kalogrides, Demetra; Loeb, Susanna

2012-07-01

More than one out of every five principals leaves their school each year. In some cases, these career changes are driven by the choices of district leadership. In other cases, principals initiate the move, often demonstrating preferences to work in schools with higher achieving students from more advantaged socioeconomic backgrounds. Principals often use schools with many poor or low-achieving students as stepping stones to what they view as more desirable assignments. We use longitudinal data from one large urban school district to study the relationship between principal turnover and school outcomes. We find that principal turnover is, on average, detrimental to school performance. Frequent turnover of school leadership results in lower teacher retention and lower student achievement gains. Leadership changes are particularly harmful for high poverty schools, low-achieving schools, and schools with many inexperienced teachers. These schools not only suffer from high rates of principal turnover but are also unable to attract experienced successors. The negative effect of leadership changes can be mitigated when vacancies are filled by individuals with prior experience leading other schools. However, the majority of new principals in high poverty and low-performing schools lack prior leadership experience and leave when more attractive positions become available in other schools. Copyright © 2012 Elsevier Inc. All rights reserved.

Immune responses of B. malayi thioredoxin (TRX) and venom allergen homologue (VAH) chimeric multiple antigen for lymphatic filariasis.

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Anugraha, Gandhirajan; Jeyaprita, Parasurama Jawaharlal; Madhumathi, Jayaprakasam; Sheeba, Tamilvanan; Kaliraj, Perumal

2013-12-01

Although multiple vaccine strategy for lymphatic filariasis has provided tremendous hope, the choice of antigens used in combination has determined its success in the previous studies. Multiple antigens comprising key vaccine candidates from different life cycle stages would provide a promising strategy if the antigenic combination is chosen by careful screening. In order to analyze one such combination, we have used a chimeric construct carrying the well studied B. malayi antigens thioredoxin (BmTRX) and venom allergen homologue (BmVAH) as a fusion protein (TV) and evaluated its immune responses in mice model. The efficacy of fusion protein vaccine was explored in comparison with the single antigen vaccines and their cocktail. In mice, TV induced significantly high antibody titer of 1,28,000 compared to cocktail vaccine TRX+VAH (50,000) and single antigen vaccine TRX (16,000) or VAH (50,000). Furthermore, TV elicited higher level of cellular proliferative response together with elevated levels of IFN-γ, IL-4 and IL-5 indicating a Th1/Th2 balanced response. The isotype antibody profile showed significantly high level of IgG1 and IgG2b confirming the balanced response elicited by TV. Immunization with TV antigen induced high levels of both humoral and cellular immune responses compared to either cocktail or antigen given alone. The result suggests that TV is highly immunogenic in mice and hence the combination needs to be evaluated for its prophylactic potential.

Traditional herbal remedies and dietary spices from Cameroon as novel sources of larvicides against filariasis mosquitoes?

Science.gov (United States)

Pavela, Roman; Maggi, Filippo; Mbuntcha, Hélène; Woguem, Verlaine; Fogang, Hervet Paulin Dongmo; Womeni, Hilaire Macaire; Tapondjou, Léon Azefack; Barboni, Luciano; Nicoletti, Marcello; Canale, Angelo; Benelli, Giovanni

2016-12-01

In Cameroon, many dietary spices are used by traditional healers to cure several diseases such as cancer and microbial infections. Aframomum daniellii, Dichrostachys cinerea and Echinops giganteus are Cameroonian spices widely used as flavourings and as food additives. Moreover, they are traditionally herbal remedies employed to treat several diseases, as well as to control populations of insect pests. In this research, we analysed the chemical composition of A. daniellii, D. cinerea and E. giganteus essential oils and we evaluated their larvicidal potential against larvae of the filariasis and West Nile virus vector Culex quinquefasciatus. The essential oils were obtained from different plant parts by hydrodistillation and their composition was analysed by GC-MS. The three spices exhibited different volatile chemical profiles, being characterized by 1,8-cineole, sabinene and β-pinene (A. daniellii), geraniol and terpinen-4-ol (D. cinerea), and silphiperfol-6-ene and presilphiperfolan-8-ol (E. giganteus). Results showed that the highest larvicidal toxicity on Cx. quinquefasciatus was exerted by D. cinerea essential oil (LC 50  = 39.1 μL L -1 ), followed by A. daniellii (pericarp essential oil: LC 50  = 65.5 μL L -1 ; leaves: LC 50  = 65.5μL L -1 ; seeds: LC 50  = 106.5μL L -1 ) and E. giganteus (LC 50  = 227.4 μL L -1 ). Overall, the chance to use the D. cinerea essential oil against Cx. quinquefasciatus young instars seems promising, since it is effective at moderate doses and could be an advantageous alternative to build newer mosquito control tools.

Effect of water resource development and management on lymphatic filariasis, and estimates of populations at risk.

Science.gov (United States)

Erlanger, Tobias E; Keiser, Jennifer; Caldas De Castro, Marcia; Bos, Robert; Singer, Burton H; Tanner, Marcel; Utzinger, Jürg

2005-09-01

Lymphatic filariasis (LF) is a debilitating disease overwhelmingly caused by Wuchereria bancrofti, which is transmitted by various mosquito species. Here, we present a systematic literature review with the following objectives: (i) to establish global and regional estimates of populations at risk of LF with particular consideration of water resource development projects, and (ii) to assess the effects of water resource development and management on the frequency and transmission dynamics of the disease. We estimate that globally, 2 billion people are at risk of LF. Among them, there are 394.5 million urban dwellers without access to improved sanitation and 213 million rural dwellers living in close proximity to irrigation. Environmental changes due to water resource development and management consistently led to a shift in vector species composition and generally to a strong proliferation of vector populations. For example, in World Health Organization (WHO) subregions 1 and 2, mosquito densities of the Anopheles gambiae complex and Anopheles funestus were up to 25-fold higher in irrigated areas when compared with irrigation-free sites. Although the infection prevalence of LF often increased after the implementation of a water project, there was no clear association with clinical symptoms. Concluding, there is a need to assess and quantify changes of LF transmission parameters and clinical manifestations over the entire course of water resource developments. Where resources allow, integrated vector management should complement mass drug administration, and broad-based monitoring and surveillance of the disease should become an integral part of large-scale waste management and sanitation programs, whose basic rationale lies in a systemic approach to city, district, and regional level health services and disease prevention.

Modeling the impact and costs of semiannual mass drug administration for accelerated elimination of lymphatic filariasis.

Directory of Open Access Journals (Sweden)

Wilma A Stolk

Full Text Available The Global Program to Eliminate Lymphatic Filariasis (LF has a target date of 2020. This program is progressing well in many countries. However, progress has been slow in some countries, and others have not yet started their mass drug administration (MDA programs. Acceleration is needed. We studied how increasing MDA frequency from once to twice per year would affect program duration and costs by using computer simulation modeling and cost projections. We used the LYMFASIM simulation model to estimate how many annual or semiannual MDA rounds would be required to eliminate LF for Indian and West African scenarios with varied pre-control endemicity and coverage levels. Results were used to estimate total program costs assuming a target population of 100,000 eligibles, a 3% discount rate, and not counting the costs of donated drugs. A sensitivity analysis was done to investigate the robustness of these results with varied assumptions for key parameters. Model predictions suggested that semiannual MDA will require the same number of MDA rounds to achieve LF elimination as annual MDA in most scenarios. Thus semiannual MDA programs should achieve this goal in half of the time required for annual programs. Due to efficiency gains, total program costs for semiannual MDA programs are projected to be lower than those for annual MDA programs in most scenarios. A sensitivity analysis showed that this conclusion is robust. Semiannual MDA is likely to shorten the time and lower the cost required for LF elimination in countries where it can be implemented. This strategy may improve prospects for global elimination of LF by the target year 2020.

A Review of the Literature on Principal Turnover

Science.gov (United States)

Snodgrass Rangel, Virginia

2018-01-01

Among the many challenges facing public schools are high levels of principal turnover. Given the important role that principals play and are expected to play in the improvement process, concerns about principal turnover have resulted in a growing body of research on its causes and consequences. The purpose of this review is to take stock of what…

Aerobic Physical Activity and the Leadership of Principals

Science.gov (United States)

Kiser, Kari

2016-01-01

The purpose of this study was to explore if there was a connection between regular aerobic physical activity and the stress and energy levels of principals as they reported it. To begin the research, the current aerobic physical activity level of principals was discovered. Additionally, the energy and stress levels of the principals who do engage…

Surface analysis the principal techniques

CERN Document Server

Vickerman, John C

2009-01-01

This completely updated and revised second edition of Surface Analysis: The Principal Techniques, deals with the characterisation and understanding of the outer layers of substrates, how they react, look and function which are all of interest to surface scientists. Within this comprehensive text, experts in each analysis area introduce the theory and practice of the principal techniques that have shown themselves to be effective in both basic research and in applied surface analysis. Examples of analysis are provided to facilitate the understanding of this topic and to show readers how they c

Subjective performance evaluations and reciprocity in principal-agent relations

DEFF Research Database (Denmark)

Sebald, Alexander Christopher; Walzl, Markus

2014-01-01

. In contrast to existing models of reciprocity, we find that agents tend to sanction whenever the feedback of principals is below their subjective self-evaluations even if agents' pay-offs are independent of it. In turn, principals provide more positive feedback (relative to their actual performance assessment......We conduct a laboratory experiment with agents working on, and principals benefiting from, a real effort task in which the agents' performance can only be evaluated subjectively. Principals give subjective performance feedback to agents, and agents have an opportunity to sanction principals...... of the agent) if this does not affect their pay-off....

Perceptions of Kentucky High School Principals and Superintendents on the Role of the Superintendent Influencing Principal Instructional Leadership

Science.gov (United States)

Hamilton, Charles L., Jr.

2011-01-01

This exploratory study surveyed the promotion of instructional leadership of high school principals by superintendents, as perceived by self and the principals they supervise. The two-phased study included an initial questionnaire administered to both study groups and comparisons of responses analyzed. All superintendents (N = 173), except the…

Role Perceptions and Job Stress among Special Education School Principals: Do They Differ from Principals of Regular Schools?

Science.gov (United States)

Gaziel, Haim Henry; Cohen-Azaria, Yael; Ermenc, Klara Skubic

2012-01-01

The objective of the present study was to compare principals' perceptions of their leadership roles in regular (Dovno, 1999) versus special education (Zaretzky, Faircloth & Moreau, 2005) schools, and how these perceptions affect feelings of job stress (Friedman, 2001; Margalit, 1999). We predicted that regular school principals would differ in…

Deformation quantization of principal fibre bundles

International Nuclear Information System (INIS)

Weiss, S.

2007-01-01

Deformation quantization is an algebraic but still geometrical way to define noncommutative spacetimes. In order to investigate corresponding gauge theories on such spaces, the geometrical formulation in terms of principal fibre bundles yields the appropriate framework. In this talk I will explain what should be understood by a deformation quantization of principal fibre bundles and how associated vector bundles arise in this context. (author)

A case study of risk factors for lymphatic filariasis in the Republic of Congo.

Science.gov (United States)

Chesnais, Cédric B; Missamou, François; Pion, Sébastien D; Bopda, Jean; Louya, Frédéric; Majewski, Andrew C; Fischer, Peter U; Weil, Gary J; Boussinesq, Michel

2014-07-01

Little is known regarding risk factors for lymphatic filariasis (LF) in Central Africa. We studied the epidemiology of LF in an endemic village in the Republic of Congo. Dependent variables were Wuchereria bancrofti antigenemia (ICT card test) and microfilaremia (night blood smears). The following factors were investigated: sex, age, bed net, latrines, source of water, uptake of anthelmintic drugs, hunting/fishing activities, and occasionally sleeping in the bush. Mixed multivariate logistic regression models were used. 134 of 774 subjects aged ≥ 5 years (17.3%) had W. bancrofti antigenemia and 41 (5.3%) had microfilaremia (mf). Infection rates increased with age up to roughly 20 years and remained stable thereafter. Multivariate analysis of antigenemia demonstrated an increased risk for males (OR = 2.0 [1.3-3.0]) and for people who hunt or fish (OR = 1.5 [1.0-2.4]) and a protective effect of latrines (OR = 0.5 [0.4-0.8]). Among males, those hunting or fishing at night had an increased risk for antigenemia (OR = 1.9 [1.1-3.5]), and use of latrines was protective (OR = 0.5 [0.3-0.9]). For females, bed nets were protective (OR = 0.4 [0.1-0.9]), and there was a strong household effect (intraclass correlation coefficient [ICC]: 0.24). When mf was used as the dependent variable, males had a higher risk for infection (OR = 5.4 [2.1-13.4]), latrines had a protective effect (OR = 0.4 [0.1-0.9]) and there was a marked household effect (ICC = 0.49). Age, sex, and occupation-dependent exposure to mosquitoes were important risk factors for infection with W. bancrofti in this study. It is likely that men often acquire infection in high transmission areas outside of the village, while children and women are infected in areas with lower transmission inside or near the village. Additional studies are needed to determine whether these findings apply to other areas in Central Africa.

Artful Dodges Principals Use to Beat Bureaucracy.

Science.gov (United States)

Ficklen, Ellen

1982-01-01

A study of Chicago (Illinois) principals revealed many ways principals practiced "creative insubordination"--avoiding following instructions but still getting things done. Among the dodges are deliberately missing deadlines, following orders literally, ignoring channels to procure teachers or materials, and using community members to…

Principal spectra describing magnetooptic permittivity tensor in cubic crystals

Energy Technology Data Exchange (ETDEWEB)

Hamrlová, Jana [Nanotechnology Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); IT4Innovations Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Legut, Dominik [IT4Innovations Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Veis, Martin [Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, Prague, 121 16 Czech Republic (Czech Republic); Pištora, Jaromír [Nanotechnology Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Hamrle, Jaroslav, E-mail: jaroslav.hamrle@vsb.cz [IT4Innovations Centre, VSB – Technical University of Ostrava, listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic); Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, Prague, 121 16 Czech Republic (Czech Republic); Department of Physics, VSB – Technical University of Ostrava, 17. listopadu 15, Ostrava, 708 33 Czech Republic (Czech Republic)

2016-12-15

We provide unified phenomenological description of magnetooptic effects being linear and quadratic in magnetization. The description is based on few principal spectra, describing elements of permittivity tensor up to the second order in magnetization. Each permittivity tensor element for any magnetization direction and any sample surface orientation is simply determined by weighted summation of the principal spectra, where weights are given by crystallographic and magnetization orientations. The number of principal spectra depends on the symmetry of the crystal. In cubic crystals owning point symmetry we need only four principal spectra. Here, the principal spectra are expressed by ab initio calculations for bcc Fe, fcc Co and fcc Ni in optical range as well as in hard and soft x-ray energy range, i.e. at the 2p- and 3p-edges. We also express principal spectra analytically using modified Kubo formula.

Community dermatology in practice: Control of morbidity in ...

African Journals Online (AJOL)

Lymphatic filariasis (LF) is a neglected disease of the poor, prevalent in 78 countries. ... the Elimination of Lymphatic Filariasis (GPELF) several years ago. The first objective is to ... In India there is no major public health intervention against filariasis. However, for ... found to have insufficient knowledge of LF when assessed ...

Reel Principals: A Descriptive Content Analysis of the Images of School Principals Depicted in Movies from 1997-2009

Science.gov (United States)

Wolfrom, Katy J.

2010-01-01

According to Glanz's early research, school principals have been depicted as autocrats, bureaucrats, buffoons, and/or villains in movies from 1950 to 1996. The purpose of this study was to determine if these stereotypical characterizations of school principals have continued in films from 1997-2009, or if more favorable images have emerged that…

The DRE-Principal Partnership: Making It Work.

Science.gov (United States)

Davis, Barbara; Elliott, Karen

1995-01-01

Discusses the roles of the director of religious education (DRE) and the school principal at Catholic schools, viewing them as complimentary rather than competitive. Provides examples of positive cooperation between the principal and DRE at Most Pure Heart of Mary Parish, in Shelby, Ohio. (KP)

New Principals' Perspectives of Their Multifaceted Roles

Science.gov (United States)

Gentilucci, James L.; Denti, Lou; Guaglianone, Curtis L.

2013-01-01

This study utilizes Symbolic Interactionism to explore perspectives of neophyte principals. Findings explain how these perspectives are modified through complex interactions throughout the school year, and they also suggest preparation programs can help new principals most effectively by teaching "soft" skills such as active listening…

Leading Learning: First-Year Principals' Reflections on Instructional Leadership

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O'Doherty, Ann; Ovando, Martha N.

2013-01-01

This qualitative study examined the instructional leadership perceptions of four first-year principals. Findings illuminate five themes drawn from the data: definitions of instructional leadership, challenges that first-year principals faced, how these principals addressed these challenges, how the novice principals plan to enact their…

Coverage and Compliance of Mass Drug Administration in Lymphatic Filariasis: A Comparative Analysis in a District of West Bengal, India

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Tanmay Kanti Panja

2012-01-01

Full Text Available Background: Despite several rounds of Mass Drug Administration (MDA as an elimination strategy of Lymphatic Filariasis (LF from India, still the coverage is far behind the required level of 85%.Objectives: The present study was carried out with the objectives to assess the coverage and compliance of MDA and their possible determinants. Methods: A cross-sectional community based study was conducted in Paschim Midnapur district of West Bengal, India for consecutive two years following MDA. Study participants were chosen by 30-cluster sampling technique. Data was collected by using pre-tested semi-structured proforma to assess the coverage and compliance of MDA along with possible determinants for non-attaining the expected coverage. Results: In the year 2009, coverage, compliance, coverage compliance gap (CCG and effective coverage was seen to be 84.1%, 70.5%, 29.5% and 59.3% respectively. In 2010, the results further deteriorated to 78.5%, 66.9%, 33.3% and 57% respectively. The poor coverage and compliance were attributed to improper training of service providers and lack of community awareness regarding MDA.Conclusion: The study emphasized supervised consumption, retraining of service providers before MDA activities, strengthening behaviour change communication strategy for community awareness. Advocacy by the program managers and policy makers towards prioritization of MDA program will make the story of filaria elimination a success.

Honouring Roles: The Story of a Principal and a Student

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Jerome Cranston

2012-11-01

Full Text Available The importance of the teacher-student relationship in educational practice is well established, as is the idea of principal leadership in relationship to staff. Even though principal leadership is regarded as a factor in student success, the principal’s effect is usually assumed to take place via the teaching staff. There is an absence of research about the “lived experience” of direct principal-student relationships that shed lights on the ways in which these relationships play a role in student success and principal transformation. This paper presents two narratives written about a particular set of principal-student interactions experienced by the researcher (principal and participant (student.  The analysis uses a narrative inquiry approach to explore both the individual and collective meanings of this principal-student relationship. The stories and their derived meanings have the potential to enliven and  influence educational practice as they explore the subtleties of the principal-student relationship.

Improving drug delivery strategies for lymphatic filariasis elimination in urban areas in Ghana.

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Nana-Kwadwo Biritwum

2017-05-01

Full Text Available The Global Program to Eliminate Lymphatic Filariasis (GPELF advocates for the treatment of entire endemic communities, in order to achieve its elimination targets. LF is predominantly a rural disease, and achieving the required treatment coverage in these areas is much easier compared to urban areas that are more complex. In Ghana, parts of the Greater Accra Region with Accra as the capital city are also endemic for LF. Mass Drug Administration (MDA in Accra started in 2006. However, after four years of treatment, the coverage has always been far below the 65% epidemiologic coverage for interrupting transmission. As such, there was a need to identify the reasons for poor treatment coverage and design specific strategies to improve the delivery of MDA. This study therefore set out to identify the opportunities and barriers for implementing MDA in urban settings, and to develop appropriate strategies for MDA in these settings. An experimental, exploratory study was undertaken in three districts in the Greater Accra region. The study identified various types of non-rural settings, the social structures, stakeholders and resources that could be employed for MDA. Qualitative assessment such as in-depth interviews (IDIs and focus group discussions (FGDs with community leaders, community members, health providers, NGOs and other stakeholders in the community was undertaken. The study was carried out in three phases: pre-intervention, intervention and post-intervention phases, to assess the profile of the urban areas and identify reasons for poor treatment coverage using both qualitative and quantitative research methods. The outcomes from the study revealed that, knowledge, attitudes and practices of community members to MDA improved slightly from the pre-intervention phase to the post-intervention phase, in the districts where the interventions were readily implemented by health workers. Many factors such as adequate leadership, funding, planning and

The Principal's Role in Site-Based Management.

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Drury, William R.

1993-01-01

In existing school-based management models, the principal's role ranges from chairing the local council to being a coach/facilitator. With teachers and parents assuming greater control over governance, curriculum, and budgeting, paranoid principals may establish more formal bargaining relationships with district boards. Caution is advised, because…

Leadership Standards in Action: The School Principal as Servant-Leader

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Brumley, Cade

2011-01-01

"Leadership Standards In Action: The School Principal as Servant-Leader" is a powerful resource for aspiring principals, practicing principals, district leadership, and university faculty. The book responsibly unpacks the metaphor of principal as servant leader to the school's people and purpose. As a framework, the six ISLLC Standards of…

Do Qualification, Experience and Age Matter for Principals Leadership Styles?

OpenAIRE

Muhammad Javed Sawati; Saeed Anwar; Muhammad Iqbal Majoka

2013-01-01

The main focus of present study was to find out the prevalent leadership styles of principals in government schools of Khyber Pakhtunkhwa and to find relationship of leadership styles with qualifications, age and experience of the principals. On the basis of analyzed data, four major leadership styles of the principals were identified as Eclectic, Democratic, Autocratic, and Free-rein. However, a small proportion of the principal had no dominant leadership style. This study shows that princip...

Integrating Technology: The Principals' Role and Effect

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Machado, Lucas J.; Chung, Chia-Jung

2015-01-01

There are many factors that influence technology integration in the classroom such as teacher willingness, availability of hardware, and professional development of staff. Taking into account these elements, this paper describes research on technology integration with a focus on principals' attitudes. The role of the principal in classroom…

Constructing principals' professional identities through life stories ...

African Journals Online (AJOL)

The Life History approach was used to collect data from six ... experience as the most significant leadership factors that influence principals' ... ranging from their entry into the teaching profession to their appointment as ..... teachers. I think I learnt from my principal to be strict but accommodating ..... Teachers College Press.

Women principals' reflections of curriculum management challenges ...

African Journals Online (AJOL)

This study reports the reflections of grade 6 rural primary principals in Mpumalanga province. A qualitative method of inquiry was used in this article, where data were collected using individual interviews with three principals and focus group discussions with the school management teams (SMTs) of three primary schools.

What Effective Principals Do to Improve Instruction and Increase Student Achievement

Science.gov (United States)

Turner, Elizabeth Anne

2013-01-01

The purposes of this mixed method study were to (a) Examine the relationships among principal effectiveness, principal instructional leadership, and student achievement; (b) examine the differences among principal effectiveness, principal instructional leadership and student achievement; and (c) investigate what effective principals do to improve…

How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis.

Science.gov (United States)

Kastner, Randee J; Sicuri, Elisa; Stone, Christopher M; Matwale, Gabriel; Onapa, Ambrose; Tediosi, Fabrizio

2017-09-01

Lymphatic filariasis (LF), a neglected tropical disease (NTD) preventable through mass drug administration (MDA), is one of six diseases deemed possibly eradicable. Previously we developed one LF elimination scenario, which assumes MDA scale-up to continue in all countries that have previously undertaken MDA. In contrast, our three previously developed eradication scenarios assume all LF endemic countries will undertake MDA at an average (eradication I), fast (eradication II), or instantaneous (eradication III) rate of scale-up. In this analysis we use a micro-costing model to project the financial and economic costs of each of these scenarios in order to provide evidence to decision makers about the investment required to eliminate and eradicate LF. Costing was undertaken from a health system perspective, with all results expressed in 2012 US dollars (USD). A discount rate of 3% was applied to calculate the net present value of future costs. Prospective NTD budgets from LF endemic countries were reviewed to preliminarily determine activities and resources necessary to undertake a program to eliminate LF at a country level. In consultation with LF program experts, activities and resources were further reviewed and a refined list of activities and necessary resources, along with their associated quantities and costs, were determined and grouped into the following activities: advocacy and communication, capacity strengthening, coordination and strengthening partnerships, data management, ongoing surveillance, monitoring and supervision, drug delivery, and administration. The costs of mapping and undertaking transmission assessment surveys and the value of donated drugs and volunteer time were also accounted for. Using previously developed scenarios and deterministic estimates of MDA duration, the financial and economic costs of interrupting LF transmission under varying rates of MDA scale-up were then modelled using a micro-costing approach. The elimination scenario

How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis.

Directory of Open Access Journals (Sweden)

Randee J Kastner

2017-09-01

Full Text Available Lymphatic filariasis (LF, a neglected tropical disease (NTD preventable through mass drug administration (MDA, is one of six diseases deemed possibly eradicable. Previously we developed one LF elimination scenario, which assumes MDA scale-up to continue in all countries that have previously undertaken MDA. In contrast, our three previously developed eradication scenarios assume all LF endemic countries will undertake MDA at an average (eradication I, fast (eradication II, or instantaneous (eradication III rate of scale-up. In this analysis we use a micro-costing model to project the financial and economic costs of each of these scenarios in order to provide evidence to decision makers about the investment required to eliminate and eradicate LF.Costing was undertaken from a health system perspective, with all results expressed in 2012 US dollars (USD. A discount rate of 3% was applied to calculate the net present value of future costs. Prospective NTD budgets from LF endemic countries were reviewed to preliminarily determine activities and resources necessary to undertake a program to eliminate LF at a country level. In consultation with LF program experts, activities and resources were further reviewed and a refined list of activities and necessary resources, along with their associated quantities and costs, were determined and grouped into the following activities: advocacy and communication, capacity strengthening, coordination and strengthening partnerships, data management, ongoing surveillance, monitoring and supervision, drug delivery, and administration. The costs of mapping and undertaking transmission assessment surveys and the value of donated drugs and volunteer time were also accounted for. Using previously developed scenarios and deterministic estimates of MDA duration, the financial and economic costs of interrupting LF transmission under varying rates of MDA scale-up were then modelled using a micro-costing approach. The

Twelve-month longitudinal parasitological assessment of lymphatic filariasis-positive individuals: impact of a biannual treatment with ivermectin and albendazole.

Science.gov (United States)

Kanamitie, John N; Ahorlu, Collins S; Otchere, Joseph; Aboagye-Antwi, Fred; Kwansa-Bentum, Bethel; Boakye, Daniel A; Biritwum, Nana-Kwadwo; Wilson, Michael D; de Souza, Dziedzom K

2017-11-01

Mass drug administration (MDA) for the control of lymphatic filariasis (LF), in Ghana, started in the year 2000. While this had great success in many implementation units, there remain areas with persistent transmission, after more than 10 years of treatment. A closer examination of the parasite populations could help understand the reasons for persistent infections and formulate appropriate strategies to control LF in these areas of persistent transmission. In a longitudinal study, we assessed the prevalence of microfilaraemia (mf) in two communities with 12 years of MDA in Ghana. In baseline surveys 6 months after the National MDA in 2014, 370 consenting individuals were tested for antigenaemia using immunochromatographic test (ICT) cards and had their mf count determined through night blood surveys. 48 ICT positives, of whom, 17 were positive for mf, were treated with 400 μg/kg ivermectin + 400 mg albendazole and subsequently followed for parasitological assessment at 3-month intervals for 1 year. This overlapped with the National MDA in 2015. There was a 68% parasite clearance 3 months after treatment. The pre-treatment mf count differed significantly from the post-treatment mf counts at 3 months (P = 0.0023), 6 months (P = 0.0051), 9 months (P = 0.0113) and 12 months (P = 0.0008). In these settings with persistent LF transmission, twice-yearly treatment may help accelerate LF elimination. Further large-scale evaluations are required to ascertain these findings. © 2017 John Wiley & Sons Ltd.

Exploring genetic variation in haplotypes of the filariasis vector Culex quinquefasciatus (Diptera: Culicidae) through DNA barcoding.

Science.gov (United States)

Vadivalagan, Chithravel; Karthika, Pushparaj; Murugan, Kadarkarai; Panneerselvam, Chellasamy; Del Serrone, Paola; Benelli, Giovanni

2017-05-01

Culex quinquefasciatus (Diptera: Culicidae) is a vector of many pathogens and parasites of humans, as well as domestic and wild animals. In urban and semi-urban Asian countries, Cx. quinquefasciatus is a main vector of nematodes causing lymphatic filariasis. In the African region, it vectors the Rift Valley fever virus, while in the USA it transmits West Nile, St. Louis encephalitis and Western equine encephalitis virus. In this study, DNA barcoding was used to explore the genetic variation of Cx. quinquefasciatus populations from 88 geographical regions. We presented a comprehensive approach analyzing the effectiveness of two gene markers, i.e. CO1 and 16S rRNA. The high threshold genetic divergence of CO1 (0.47%) gene was reported as an ideal marker for molecular identification of this mosquito vector. Furthermore, null substitutions were lower in CO1 if compared to 16S rRNA, which influenced its differentiating potential among Indian haplotypes. NJ tree was well supported with high branch values for CO1 gene than 16S rRNA, indicating ideal genetic differentiation among haplotypes. TCS haplotype network revealed 14 distinct clusters. The intra- and inter-population polymorphism were calculated among the global and Indian Cx. quinquefasciatus lineages. The genetic diversity index Tajima' D showed negative values for all the 4 intra-population clusters (G2-4, G10). Fu's FS showed negative value for G10 cluster, which was significant and indicated recent population expansion. However, the G2-G4 (i.e. Indian lineages) had positive values, suggesting a bottleneck effect. Overall, our research firstly shed light on the genetic differences among the haplotypes of Cx. quinquefasciatus species complex, adding basic knowledge to the molecular ecology of this important mosquito vector. Copyright © 2017 Elsevier B.V. All rights reserved.

Contemporary Challenges and Changes: Principals' Leadership Practices in Malaysia

Science.gov (United States)

Jones, Michelle; Adams, Donnie; Joo, Mabel Tan Hwee; Muniandy, Vasu; Perera, Corinne Jaqueline; Harris, Alma

2015-01-01

This article outlines the findings from a contemporary study of principals' leadership practices in Malaysia as part of the 7 System Leadership Study. Recent policy developments within Malaysia have increased principals' accountability and have underlined the importance of the role of the principals in transforming school performance and student…

3D face recognition with asymptotic cones based principal curvatures

KAUST Repository

Tang, Yinhang

2015-05-01

The classical curvatures of smooth surfaces (Gaussian, mean and principal curvatures) have been widely used in 3D face recognition (FR). However, facial surfaces resulting from 3D sensors are discrete meshes. In this paper, we present a general framework and define three principal curvatures on discrete surfaces for the purpose of 3D FR. These principal curvatures are derived from the construction of asymptotic cones associated to any Borel subset of the discrete surface. They describe the local geometry of the underlying mesh. First two of them correspond to the classical principal curvatures in the smooth case. We isolate the third principal curvature that carries out meaningful geometric shape information. The three principal curvatures in different Borel subsets scales give multi-scale local facial surface descriptors. We combine the proposed principal curvatures with the LNP-based facial descriptor and SRC for recognition. The identification and verification experiments demonstrate the practicability and accuracy of the third principal curvature and the fusion of multi-scale Borel subset descriptors on 3D face from FRGC v2.0.

3D face recognition with asymptotic cones based principal curvatures

KAUST Repository

Tang, Yinhang; Sun, Xiang; Huang, Di; Morvan, Jean-Marie; Wang, Yunhong; Chen, Liming

2015-01-01

The classical curvatures of smooth surfaces (Gaussian, mean and principal curvatures) have been widely used in 3D face recognition (FR). However, facial surfaces resulting from 3D sensors are discrete meshes. In this paper, we present a general framework and define three principal curvatures on discrete surfaces for the purpose of 3D FR. These principal curvatures are derived from the construction of asymptotic cones associated to any Borel subset of the discrete surface. They describe the local geometry of the underlying mesh. First two of them correspond to the classical principal curvatures in the smooth case. We isolate the third principal curvature that carries out meaningful geometric shape information. The three principal curvatures in different Borel subsets scales give multi-scale local facial surface descriptors. We combine the proposed principal curvatures with the LNP-based facial descriptor and SRC for recognition. The identification and verification experiments demonstrate the practicability and accuracy of the third principal curvature and the fusion of multi-scale Borel subset descriptors on 3D face from FRGC v2.0.

Evaluating the Burden of Lymphedema Due to Lymphatic Filariasis in 2005 in Khurda District, Odisha State, India.

Directory of Open Access Journals (Sweden)

Victoria Walsh

2016-08-01

Full Text Available Over 1.1 billion people worldwide are at risk for lymphatic filariasis (LF, and the global burden of LF-associated lymphedema is estimated at 16 million affected people, yet country-specific estimates are poor.A house-to-house morbidity census was conducted to assess the burden and severity of lymphedema in a population of 1,298,576 persons living in the LF-endemic district of Khurda in Odisha State, India. The burden of lymphedema in Khurda is widespread geographically, and 1.3% (17,036 of the total population report lymphedema. 51.3% of the patients reporting lymphedema were female, mean age 49.4 years (1-99. Early lymphedema (Dreyer stages 1 & 2 was reported in two-thirds of the patients. Poisson regression analysis was conducted in order to determine risk factors for advanced lymphedema (Dreyer stages 4-7. Increasing age was significantly associated with advanced lymphedema, and persons 70 years and older had a prevalence three times greater than individuals ages 15-29 (aPR: 3.21, 95% CI 2.45, 4.21. The number of adenolymphangitis (ADL episodes reported in the previous year was also significantly associated with advanced lymphedema (aPR 4.65, 95% CI 2.97-7.30. This analysis is one of the first to look at potential risk factors for advanced lymphedema using morbidity census data from an entire district in Odisha State, India.These data highlight the magnitude of lymphedema in LF-endemic areas and emphasize the need to develop robust estimates of numbers of individuals with lymphedema in order to identify the extent of lymphedema management services needed in these regions.

Principal bundles the classical case

CERN Document Server

Sontz, Stephen Bruce

2015-01-01

This introductory graduate level text provides a relatively quick path to a special topic in classical differential geometry: principal bundles.  While the topic of principal bundles in differential geometry has become classic, even standard, material in the modern graduate mathematics curriculum, the unique approach taken in this text presents the material in a way that is intuitive for both students of mathematics and of physics. The goal of this book is to present important, modern geometric ideas in a form readily accessible to students and researchers in both the physics and mathematics communities, providing each with an understanding and appreciation of the language and ideas of the other.

Taking a Distributed Perspective to the School Principal's Workday

Science.gov (United States)

Spillane, James P.; Camburn, Eric M.; Pareja, Amber Stitziel

2007-01-01

Focusing on the school principal's day-to-day work, we examine who leads curriculum and instruction- and administration-related activities when the school principal is not leading but participating in the activity. We also explore the prevalence of coperformance of management and leadership activities in the school principal's workday. Looking…

Principal Preparation in Special Education: Building an Inclusive Culture

Science.gov (United States)

Hofreiter, Deborah

2017-01-01

The importance of principal preparation in special education has increased since the Education for All Handicapped Children Act was passed in 1975. There are significant financial reasons for preparing principals in the area of special education. Recent research also shows that all children learn better in an inclusive environment. Principals who…

Urban School Principals and Their Role as Multicultural Leaders

Science.gov (United States)

Gardiner, Mary E.; Enomoto, Ernestine K.

2006-01-01

This study focuses on the role of urban school principals as multicultural leaders. Using cross-case analysis, the authors describe what 6 practicing principals do in regard to multicultural leadership. The findings suggest that although multicultural preparation was lacking for these principals, some did engage in work that promoted diversity in…

Principals: Human Capital Managers at Every School

Science.gov (United States)

Kimball, Steven M.

2011-01-01

Being a principal is more than just being an instructional leader. Principals also must manage their schools' teaching talent in a strategic way so that it is linked to school instructional improvement strategies, to the competencies needed to enact the strategies, and to success in boosting student learning. Teacher acquisition and performance…

The Effects of Reform in Principal Selection on Leadership Behavior of General and Vocational High School Principals in Taiwan

Science.gov (United States)

Hsiao, Hsi-Chi; Lee, Ming-Chao; Tu, Ya-Ling

2013-01-01

Deregulation has formed the primary core of education reform in Taiwan in the past decade. The principal selection system was one of the specific recommendations in the deregulation of education. The method of designation of senior high school principals has changed from being "appointed" to being "selected." The issue as to…

Principal Holistic Judgments and High-Stakes Evaluations of Teachers

Science.gov (United States)

Briggs, Derek C.; Dadey, Nathan

2017-01-01

Results from a sample of 1,013 Georgia principals who rated 12,617 teachers are used to compare holistic and analytic principal judgments with indicators of student growth central to the state's teacher evaluation system. Holistic principal judgments were compared to mean student growth percentiles (MGPs) and analytic judgments from a formal…

Job Satisfaction of Elementary Principals in Large Urban Communities

Science.gov (United States)

Mitchell, Cathryn M.

2010-01-01

The purpose of this study was to determine job satisfaction levels of elementary principals in "major urban" districts in Texas and to identify strategies these principals used to cope with the demands of the position. Additionally, the project sought to find structures and supports needed to attract and retain principals in the…

Leadership Behaviors and Its Relation with Principals' Management Experience

Science.gov (United States)

Mehdinezhad, Vali; Sardarzahi, Zaid

2016-01-01

This paper aims at studying the leadership behaviors reported by principals and observed by teachers and its relationship with management experience of principals. A quantitative method was used in this study. The target population included all principals and teachers of guidance schools and high schools in the Dashtiari District, Iran. A sample…

Building Leadership Capacity to Support Principal Succession

Science.gov (United States)

Escalante, Karen Elizabeth

2016-01-01

This study applies transformational leadership theory practices, specifically inspiring a shared vision, modeling the way and enabling others to act to examine the purposeful ways in which principals work to build the next generation of teacher leaders in response to the dearth of K-12 principals. The purpose of this study was to discover how one…

Multilevel sparse functional principal component analysis.

Science.gov (United States)

Di, Chongzhi; Crainiceanu, Ciprian M; Jank, Wolfgang S

2014-01-29

We consider analysis of sparsely sampled multilevel functional data, where the basic observational unit is a function and data have a natural hierarchy of basic units. An example is when functions are recorded at multiple visits for each subject. Multilevel functional principal component analysis (MFPCA; Di et al. 2009) was proposed for such data when functions are densely recorded. Here we consider the case when functions are sparsely sampled and may contain only a few observations per function. We exploit the multilevel structure of covariance operators and achieve data reduction by principal component decompositions at both between and within subject levels. We address inherent methodological differences in the sparse sampling context to: 1) estimate the covariance operators; 2) estimate the functional principal component scores; 3) predict the underlying curves. Through simulations the proposed method is able to discover dominating modes of variations and reconstruct underlying curves well even in sparse settings. Our approach is illustrated by two applications, the Sleep Heart Health Study and eBay auctions.

Principals, Trust, and Cultivating Vibrant Schools

Directory of Open Access Journals (Sweden)

Megan Tschannen-Moran

2015-03-01

Full Text Available Although principals are ultimately held accountable to student learning in their buildings, the most consistent research results have suggested that their impact on student achievement is largely indirect. Leithwood, Patten, and Jantzi proposed four paths through which this indirect influence would flow, and the purpose of this special issue is to examine in greater depth these mediating variables. Among mediating variables, we assert that trust is key. In this paper, we explore the evidence that points to the role that faculty trust in the principal plays in student learning and how principals can cultivate trust by attending to the five facets of trust, as well as the correlates of trust that mediate student learning, including academic press, collective teacher efficacy, and teacher professionalism. We argue that trust plays a role in each of the four paths identified by Leithwood, Patten, and Jantzi. Finally, we explore possible new directions for future research.

Principal noncommutative torus bundles

DEFF Research Database (Denmark)

Echterhoff, Siegfried; Nest, Ryszard; Oyono-Oyono, Herve

2008-01-01

of bivariant K-theory (denoted RKK-theory) due to Kasparov. Using earlier results of Echterhoff and Williams, we shall give a complete classification of principal non-commutative torus bundles up to equivariant Morita equivalence. We then study these bundles as topological fibrations (forgetting the group...

Principal Investigator-in-a-Box

Science.gov (United States)

Young, Laurence R.

1999-01-01

Human performance in orbit is currently limited by several factors beyond the intrinsic awkwardness of motor control in weightlessness. Cognitive functioning can be affected by such factors as cumulative sleep loss, stress and the psychological effects of long-duration small-group isolation. When an astronaut operates a scientific experiment, the performance decrement associated with such factors can lead to lost or poor quality data and even the total loss of a scientific objective, at great cost to the sponsors and to the dismay of the Principal Investigator. In long-duration flights, as anticipated on the International Space Station and on any planetary exploration, the experimental model is further complicated by long delays between training and experiment, and the large number of experiments each crew member must perform. Although no documented studies have been published on the subject, astronauts report that an unusually large number of simple errors are made in space. Whether a result of the effects of microgravity, accumulated fatigue, stress or other factors, this pattern of increased error supports the need for a computerized decision-making aid for astronauts performing experiments. Artificial intelligence and expert systems might serve as powerful tools for assisting experiments in space. Those conducting space experiments typically need assistance exactly when the planned checklist does not apply. Expert systems, which use bits of human knowledge and human methods to respond appropriately to unusual situations, have a flexibility that is highly desirable in circumstances where an invariably predictable course of action/response does not exist. Frequently the human expert on the ground is unavailable, lacking the latest information, or not consulted by the astronaut conducting the experiment. In response to these issues, we have developed "Principal Investigator-in-a-Box," or [PI], to capture the reasoning process of the real expert, the Principal

African-American Female Students and STEM: Principals' Leadership Perspectives

Science.gov (United States)

Sampson, Kristin Morgan

As the U.S. becomes more diverse, school leaders, major corporations, and areas of national defense continue to investigate science, technology, engineering and math (STEM) education issues. African-American female students have historically been underrepresented in STEM fields, yet educational leadership research, examining this population is limited. The purpose of this qualitative study was to explore how principals support African-American female students in schools with a STEM program. The Critical Race Theory (CRT)was used as a theoretical framework to highlight the inadequacies to support educational inequalities. The application of the CRT in this study is due to the embedded inequality practices within the educational system, that have resulted in the underrepresentation of African-American female students in STEM. To complement CRT, the transformative leadership model was also utilized to examine the emancipatory leadership practices principals utilized. These theories framed the context of this study by recognizing the need to address how support is actualized to African-American female students in STEM by their principals. A case study approach was an appropriate method to answer the two research questions, 1) How do principals feel they support African-American female students in their STEM programs? and 2) What practices do principals engage in that support underrepresented students in STEM? This approach intended to uncover how a principal leads a multifaceted population of underrepresented students in STEM programs. Two principals of STEM schools, where more than 50% of the population were African-American, were interviewed and observed completing daily operations at community-wide events. The STEM Coordinators and a teacher were also interviewed, and test scores were examined to provide further information about the STEM program, and public records were obtained to analyze the principals' means of communication. I found that principals supported

Incremental Tensor Principal Component Analysis for Handwritten Digit Recognition

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Chang Liu

2014-01-01

Full Text Available To overcome the shortcomings of traditional dimensionality reduction algorithms, incremental tensor principal component analysis (ITPCA based on updated-SVD technique algorithm is proposed in this paper. This paper proves the relationship between PCA, 2DPCA, MPCA, and the graph embedding framework theoretically and derives the incremental learning procedure to add single sample and multiple samples in detail. The experiments on handwritten digit recognition have demonstrated that ITPCA has achieved better recognition performance than that of vector-based principal component analysis (PCA, incremental principal component analysis (IPCA, and multilinear principal component analysis (MPCA algorithms. At the same time, ITPCA also has lower time and space complexity.

An Assessment of the Perceived Instructional Leadership Behaviors of Assistant Principals

Science.gov (United States)

Atkinson, Ronald E., Jr.

2013-01-01

This study examined the extent to which the role of the assistant principal is perceived to include instructional leadership behaviors. Specifically, this study compared the perceptions of instructional leadership practices of elementary, middle, and high school assistant principals from the perspectives of assistant principals, principals, and…

Location and characterisation of pollution sites by principal ...

African Journals Online (AJOL)

Location and characterisation of pollution sites by principal component analysis of trace contaminants in a slightly polluted seasonal river: a case study of the Arenales River (Salta, Argentina) ... Keywords: trace element contamination, water quality, principal component analysis, Arenales River, Salta, Argentina ...

Two Charter School Principals' Engagement in Instructional Leadership

Science.gov (United States)

Bickmore, Dana L.; Sulentic Dowell, Margaret-Mary

2014-01-01

This comparative case (Merriam, 2009) study explored two charter school principals' engagement in instructional leadership. Analysis of three data sources--interviews, observations, and documents--revealed that principals were almost exclusively focused on state accountability and possessed limited knowledge of pedagogical practices. In…

Empowering principals to lead and manage public schools ...

African Journals Online (AJOL)

Globally, education systems have been affected by radical social, political and economic changes. Although school principals play a pivotal role in improving student learning and attaining educational outcomes, they work under strenuous conditions to deal with multifaceted transformational issues. Principals experience ...

Euler principal component analysis

NARCIS (Netherlands)

Liwicki, Stephan; Tzimiropoulos, Georgios; Zafeiriou, Stefanos; Pantic, Maja

Principal Component Analysis (PCA) is perhaps the most prominent learning tool for dimensionality reduction in pattern recognition and computer vision. However, the ℓ 2-norm employed by standard PCA is not robust to outliers. In this paper, we propose a kernel PCA method for fast and robust PCA,

School Principals' Perceptions of Ethically Just Responses to a Student Sexting Vignette: Severity of Administrator Response, Principal Personality, and Offender Gender and Race

Science.gov (United States)

Moriarty, Margaret E.

2012-01-01

This mixed-methods study was designed to determine how principals perceived the ethicality of sanctions for students engaged in sexting behavior relative to the race/ethnicity and gender of the student. Personality traits of the principals were surveyed to determine if Openness and/or Conscientiousness would predict principal response. Sexting is…

Use of Sparse Principal Component Analysis (SPCA) for Fault Detection

DEFF Research Database (Denmark)

Gajjar, Shriram; Kulahci, Murat; Palazoglu, Ahmet

2016-01-01

Principal component analysis (PCA) has been widely used for data dimension reduction and process fault detection. However, interpreting the principal components and the outcomes of PCA-based monitoring techniques is a challenging task since each principal component is a linear combination of the ...

Informing principal policy reforms in South Africa through data-based evidence

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Gabrielle Wills

2015-12-01

Full Text Available In the past decade there has been a notable shift in South African education policy that raises the value of school leadership as a lever for learning improvements. Despite a growing discourse on school leadership, there has been a lack of empirical based evidence on principals to inform, validate or debate the efficacy of proposed policies in raising the calibre of school principals. Drawing on findings from a larger study to understand the labour market for school principals in South Africa, this paper highlights four overarching characteristics of this market with implications for informing principal policy reforms. The paper notes that improving the design and implementation of policies guiding the appointment process for principals is a matter of urgency. A substantial and increasing number of principal replacements are taking place across South African schools given a rising age profile of school principals. In a context of low levels of principal mobility and high tenure, the leadership trajectory of the average school is established for nearly a decade with each principal replacement. Evidence-based policy making has a strong role to play in getting this right.

Preschool Principal's Curriculum Leadership Indicators: A Taiwan Perspective

Science.gov (United States)

Lin, Chia-Fen; Lee, John Chi-Kin

2013-01-01

The role of a principal's curriculum leadership has become an educational issue in Taiwan's early childhood education. This study represents a pioneering attempt in adopting a target school interview, fuzzy Delphi, and analytic hierarchy process for constructing preschool principal's curriculum leadership indicators. Fifteen experts and…

Delegation of Monitoring in a Principal-Agent Relationship

NARCIS (Netherlands)

Strausz, R.G.

1995-01-01

This paper studies a principal-agent relationship with moral hazard in which the principal or the supervisor can monitor the agent's hidden action by using identical monitoring technologies. The paper shows that delegation of monitoring to the supervisor is profitable because of two effects. With

COMPETENCE OF SCHOOL PRINCIPALS REGARDING KNOWLEDGE MANAGEMENT IN ELEMENTARY SCHOOLS

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Gökmen DAĞLI

2007-12-01

Full Text Available This research aims to determine the manner of school principals regarding knowledge managementin primary school education. The research is a subjective one conducted in general scanning method. Personal informationform and five-likert scale are the main means in which data was collected. During the data collection stage, school principalswere requested to provide information about the way in which they obtain, share, process, evaluate knowledge, take decisionand analyze problems within the scope of knowledge management. In the virtue of the data acquired, the research shows that;the school principals obtain knowledge by attending meetings with teachers, making personal observation, their personalexperience and online resources. Regarding the sharing of knowledge, the research shows the principals always shareknowledge with their assistant principals and teachers; in using of knowledge, decision making and analyzing problemsresearch also shows that principals take decisions in co-operation with assistant principals and teachers. Last but not least,research shows that in storing the knowledge principals mainly use computers and traditional filing techniques. Seminarsshould be organized periodically by specialists with respect to acquiring, sharing, using and also filling knowledge followingdecision-making in order for school administrators to keep abreast of the latest developments in knowledge management

How the Principalship Has Changed: Lessons from Principals' Life Stories.

Science.gov (United States)

Brubaker, Dale L.

1995-01-01

The life stories of (North Carolina) principals in a graduate education class reveal vast changes over the past 20 years. "Good ol' boy" superintendents and principals have been replaced by self-interested political "sharks" concerned more with image than substance. Fortunately, principals with resiliency, caring values, and…

The Principal-Agent model and the European Union

NARCIS (Netherlands)

Delreux, Tom; Adriaensen, J.

2017-01-01

This book assesses the use and limitations of the principal-agent model in a context of increasingly complex political systems such as the European Union. Whilst a number of conceptual, theoretical and methodological challenges need to be addressed, the authors show that the principal-agent model

Career Paths in Educational Leadership: Examining Principals' Narratives

Science.gov (United States)

Parylo, Oksana; Zepeda, Sally J.; Bengtson, Ed

2012-01-01

This qualitative study analyzes the career path narratives of active principals. Structural narrative analysis was supplemented with sociolinguistic theory and thematic narrative analysis to discern the similarities and differences, as well as the patterns in the language used by participating principals. Thematic analysis found four major themes…

Principals' Perceptions of Their Knowledge in Special Education

Science.gov (United States)

Roberts, Maria Banda; Guerra, Federico R., Jr.

2017-01-01

With the "Every Student Succeeds Act" continuing to legislate accountability for special education and Hispanic students, the appropriate content in principal preparation programs relevant to successful leadership of special education programs is vital. This mixed methods study analyzed the survey responses of 84 principals in South…

Learning Leaders: How Do Award-Winning Principals Learn and Grow? Are There Commonalities in the Professional Development Practices of NAESP/NASSP Award-Winning Principals?

Science.gov (United States)

Hansen, Mark

2013-01-01

The role a principal plays in school improvement has evolved over time. The transition from principal as manager to principal as instructional leader began with and was driven in large part by the effective schools movement of the 1970's and 1980's (Hallinger, 2003; Zigarelli, 1996). Since the inception of NCLB in 2001, the leader's role in…

Common Core Implementation Decisions Made by Principals in Elementary Schools

Science.gov (United States)

Norman, Alexis Cienfuegos

2016-01-01

The purpose of this study was to understand the decisions elementary principals have made during the Common Core State Standards reform. Specifically, (a) what decisions principals have made to support Common Core implementation, (b) what strategies elementary principals have employed to communicate with stakeholders about Common Core State…

Principals' Perception of Educational Inputs and Students' Academic ...

African Journals Online (AJOL)

This study investigated principals' perception of the relationship between educational inputs and academic performance of students in public junior secondary schools (JSS) in the Central Senatorial District of Delta State, Nigeria. The population was all the 173 public JSS and their principals from which a sample of twenty ...

Principal Preservice Education for Leadership in Inclusive Schools

Science.gov (United States)

Lyons, Wanda

2016-01-01

Principal leadership has been identified as the key to successful implementation of inclusive education for students with disabilities. Prospective principals require knowledge, skills, and dispositions to equip them to work with key stakeholders to initiate and sustain inclusive practices within their schools. The purpose of this action research…

Teacher Contract Non-Renewal: What Matters to Principals?

Science.gov (United States)

Nixon, Andy; Packard, Abbot; Dam, Margaret

2016-01-01

This quantitative study investigated the relationship between teacher dispositions, subject content knowledge, pedagogical content knowledge, and reasons that school principals recommend non-renewal of teachers' contracts. Nearly 2,000 school principals in 13 states completed an emailed survey. In deciding whether to non-renew a teacher contract,…

Defamation of and by Principals. A Legal Memorandum.

Science.gov (United States)

Zirkel, Perry A.

Defamation is a common-law claim for liability that encompasses "libel," which is the written form, and "slander," which is the oral form. School principals can be plaintiffs or defendants in defamation suits. Relevant case law provides illustrations of the various elements of defamation for both roles of the principal. Court…

Principals' Perceptions of Needs in Hispanic Special Education

Science.gov (United States)

Roberts, Maria B.; Guerra, Federico, Jr.

2017-01-01

This mixed methods study used a survey by Frost and Kersten to answer the following questions: (a) Do principals of predominantly Hispanic schools perceive themselves as having adequate knowledge in special education? (b) Which areas are these principals most involved in with special education teachers? (c) What suggestions do these principals…

Primary School Principals' Job Satisfaction and Occupational Stress

Science.gov (United States)

Darmody, Merike; Smyth, Emer

2016-01-01

Purpose: The purpose of this paper is to explore the factors associated with occupational stress and job satisfaction among Irish primary school principals. A principal's job has become increasingly demanding and complex in recent decades. However, there is little current research into their levels of stress and job satisfaction, particularly…

Circulating filarial antigen in the hydrocele fluid from individuals living in a bancroftian filariasis area - Recife, Brazil: detected by the monoclonal antibody Og4C3-assay

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Abraham Rocha

2004-02-01

Full Text Available The purpose of this study was to examine the circulating filarial antigen (CFA detected by the monoclonal antibody (mAb Og4C3-ELISA in paired samples of serum and hydrocele fluid from 104 men with hydrocele, living in an endemic area of Wuchereria bancrofti. Nocturnal blood specimens were filtered and examined for microfilariae (MF and ultrasound was used in order to identify the presence of adult worms (the filaria dance sign - FDS in the lymphatic vessels of the scrotal area. Four groups were selected according to their parasitological status: group I - 71 MF- and FDS-; group II - 21 MF+ and FDS+; group III - 10 MF- and FDS+ and group IV- 2 MF+ and FDS-. CFA was identified simultaneously (fluid and serum in 11 (15.5%, 21 (100%, 3 (30%, and 1 (50% in groups I, II, III, and IV, respectively. In despite of high CFA+ level (antigen Og4C3 units/ml, the Geometrical Mean (GM = 2696 in the sera of these 36/104 paired samples, when compared to the hydrocele fluid, (GM = 1079, showed a very good correlation between the CFA level in the serum and CFA level in the fluid (r = 0.731. CFA level in the serum of the 23 microfilaremics (groups II and IV was extremely high (GM = 4189 and was correlated with MF density (r = 0.442. These findings report for the first time the potential alternative use of the hydrocele fluid to investigate CFA using the mAb Og4C3-ELISA.

Principals' Perceived Supervisory Behaviors Regarding Marginal Teachers in Two States

Science.gov (United States)

Range, Bret; Hewitt, Paul; Young, Suzie

2014-01-01

This descriptive study used an online survey to determine how principals in two states viewed the supervision of marginal teachers. Principals ranked their own evaluation of the teacher as the most important factor when identifying marginal teachers and relied on informal methods to diagnose marginal teaching. Female principals rated a majority of…

relationship between principals' management approaches

African Journals Online (AJOL)

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Data were collected using a self-administered questionnaire from a sample of. 211 teachers, 28 principals and 22 chairpersons of parent- teachers association. Data were ..... their role expectation in discipline management. Data from the 20 ...

Honouring Roles: The Story of a Principal and a Student

Science.gov (United States)

Cranston, Jerome

2012-01-01

The importance of the teacher-student relationship in educational practice is well established, as is the idea of principal leadership in relationship to staff. Even though principal leadership is regarded as a factor in student success, the principal's effect is usually assumed to take place via the teaching staff. There is an absence of research…

Principals' Leadership Styles and ESL Teachers' Job Satisfaction

Science.gov (United States)

Jackson, K. A'jaydin

2013-01-01

The purpose of this research study was to examine principals' leadership styles and how and what extent it impacted teachers' job satisfaction. Principals' leadership styles were examined by middle and high school teachers' perceptions. This study drew from 10 middle and 10 high schools in a large school district located in Texas. Participants…

"Mujeres" in the Principal's Office: Latina School Leaders

Science.gov (United States)

Méndez-Morse, Sylvia; Murakami, Elizabeth T.; Byrne-Jiménez, Mónica; Hernandez, Frank

2015-01-01

This article is based on a national survey of Latina/o principals and assistant principals conducted by the National Latina/o Leadership Project and focuses on the women participants. Included is a description of Latinas' leadership experiences, their career paths, and the influence of racial/ethnic identity on their leadership practice. The…

Latina/o School Principals: Identity, Leadership and Advocacy

Science.gov (United States)

Murakami, Elizabeth T.; Hernandez, Frank; Mendez-Morse, Sylvia; Byrne-Jimenez, Monica

2016-01-01

This study sought to further define and inform about the influence of Latina/o principals in schools as an alternative to traditional forms of leadership. The principals' Latina/o identity, their leadership styles and advocacy towards the improvement of student achievement were examined. This research focused on three questions: (a) How did…

The Principal as CEO

Science.gov (United States)

Hollar, Charlie

2004-01-01

They may never grace the pages of The Wall Street Journal or Fortune magazine, but they might possibly be the most important CEOs in our country. They are elementary school principals. Each of them typically serves the learning needs of 350-400 clients (students) while overseeing a multimillion-dollar facility staffed by 20-25 teachers and 10-15…

Anglo-American views of Gavrilo Princip

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Markovich Slobodan G.

2015-01-01

Full Text Available The paper deals with Western (Anglo-American views on the Sarajevo assassination/attentat and Gavrilo Princip. Articles on the assassination and Princip in two leading quality dailies (The Times and The New York Times have particularly been analysed as well as the views of leading historians and journalists who covered the subject including: R. G. D. Laffan, R. W. Seton-Watson, Winston Churchill, Sidney Fay, Bernadotte Schmitt, Rebecca West, A. J. P. Taylor, Vladimir Dedijer, Christopher Clark and Tim Butcher. In the West, the original general condemnation of the assassination and its main culprits was challenged when Rebecca West published her famous travelogue on Yugoslavia in 1941. Another Brit, the remarkable historian A. J. P. Taylor, had a much more positive view on the Sarajevo conspirators and blamed Germany and Austria-Hungary for the outbreak of the Great War. A turning point in Anglo-American perceptions was the publication of Vladimir Dedijer’s monumental book The Road to Sarajevo (1966, which humanised the main conspirators, a process initiated by R. West. Dedijer’s book was translated from English into all major Western languages and had an immediate impact on the understanding of the Sarajevo assassination. The rise of national antagonisms in Bosnia gradually alienated Princip from Bosnian Muslims and Croats, a process that began in the 1980s and was completed during the wars of the Yugoslav succession. Although all available sources clearly show that Princip, an ethnic Serb, gradually developed a broader Serbo-Croat and Yugoslav identity, he was ethnified and seen exclusively as a Serb by Bosnian Croats and Bosniaks and Western journalists in the 1990s. In the past century imagining Princip in Serbia and the West involved a whole spectrum of views. In interwar Anglo-American perceptions he was a fanatic and lunatic. He became humanised by Rebecca West (1941, A. J. P. Taylor showed understanding for his act (1956, he was fully

Principal component regression for crop yield estimation

CERN Document Server

Suryanarayana, T M V

2016-01-01

This book highlights the estimation of crop yield in Central Gujarat, especially with regard to the development of Multiple Regression Models and Principal Component Regression (PCR) models using climatological parameters as independent variables and crop yield as a dependent variable. It subsequently compares the multiple linear regression (MLR) and PCR results, and discusses the significance of PCR for crop yield estimation. In this context, the book also covers Principal Component Analysis (PCA), a statistical procedure used to reduce a number of correlated variables into a smaller number of uncorrelated variables called principal components (PC). This book will be helpful to the students and researchers, starting their works on climate and agriculture, mainly focussing on estimation models. The flow of chapters takes the readers in a smooth path, in understanding climate and weather and impact of climate change, and gradually proceeds towards downscaling techniques and then finally towards development of ...

School Principals' Technology Leadership Competency and Technology Coordinatorship

Science.gov (United States)

Banoglu, Koksal

2011-01-01

The aim of this study is to determine the primary and high school principals' competency in technology leadership and so to define implications for advanced competency. The population of the study was formed by 134 school principals in Maltepe and Kadikoy districts in Istanbul. On account of the fact that population was reachable, no specific…

Implications for Research: Preparing Principals for Leadership Roles.

Science.gov (United States)

Hord, Shirley M.; Thurber, John C.

Recent research has shown that, to exercise more effective leadership, principals need to match their behaviors with the appropriate needs and concerns of teachers. Concepts and tools from work done by the Research on Concerns-Based Adoption Project at the Austin campus of the University of Texas were employed to provide principals in the Palm…

The Development of Faith Leadership in Novice Principals

Science.gov (United States)

Rieckhoff, Barbara Stacy

2014-01-01

This article describes the Catholic School Principal Support Program (CSPSP), a mentoring program for first and second-year Catholic school principals in a large urban diocese, and identifies key challenges, impacts and influences on decision-making. Ten school leaders describe their work and provide the lens by which they reflect on their role as…

First-Year Principal Encounters Homophobia

Science.gov (United States)

Retelle, Ellen

2011-01-01

A 1st-year principal encounters homonegativity and an ethical dilemma when she attempts to terminate a teacher because of the teacher's inadequate and ineffective teaching. The teacher responds by threatening to "out" Ms. L. to the parents.

The Leadership Roles of a Principal in Improving School Effectiveness

Directory of Open Access Journals (Sweden)

Burhanuddin Burhanuddin

2016-02-01

Full Text Available The purpose of this study was to investigate the leadership roles and practices of the principal in improving school effectiveness. This descriptive study involved the principal , counselor, and 11 teachers from the Tonsley Park Primary School in South Australia. The findings showed that all respondents generally regarded team leader as the most important role, while supervisor was rated as the least important. Of the 20 tasks observed, generally revealed that a principal should work cooperatively with staff to ensure more effective use of their skills. While, the task of a principal in making decisions on staff development programs was not necessarily expected by the practicing teachers. All respondents considered organization coordination as the most important area within which a principal should provide more leadership, while curriculum or instructional improvement and innovation was regarded as the least important

Principals' and Teachers' Attitudes towards Inclusion in Israel

Science.gov (United States)

Hess, Itay; Zamir, Sara

2016-01-01

The main goal of this study was to determine whether, in schools that practice inclusion, there is a correlation between the attitudes of school principals and teachers in their schools, towards inclusion of student with special needs. For this purpose, 38 schools were sampled in each of which the school principal and five teachers who work with…

A community-based study of factors associated with continuing transmission of lymphatic filariasis in Leogane, Haiti.

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Alexis Boyd

Full Text Available Seven rounds of mass drug administration (MDA have been administered in Leogane, Haiti, an area hyperendemic for lymphatic filariasis (LF. Sentinel site surveys showed that the prevalence of microfilaremia was reduced to <1% from levels as high as 15.5%, suggesting that transmission had been reduced. A separate 30-cluster survey of 2- to 4-year-old children was conducted to determine if MDA interrupted transmission. Antigen and antifilarial antibody prevalence were 14.3% and 19.7%, respectively. Follow-up surveys were done in 6 villages, including those selected for the cluster survey, to assess risk factors related to continued LF transmission and to pinpoint hotspots of transmission. One hundred houses were mapped in each village using GPS-enabled PDAs, and then 30 houses and 10 alternates were chosen for testing. All individuals in selected houses were asked to participate in a short survey about participation in MDA, history of residence in Leogane and general knowledge of LF. Survey teams returned to the houses at night to collect blood for antigen testing, microfilaremia and Bm14 antibody testing and collected mosquitoes from these communities in parallel. Antigen prevalence was highly variable among the 6 villages, with the highest being 38.2% (Dampus and the lowest being 2.9% (Corail Lemaire; overall antigen prevalence was 18.5%. Initial cluster surveys of 2- to 4-year-old children were not related to community antigen prevalence. Nearest neighbor analysis found evidence of clustering of infection suggesting that LF infection was focal in distribution. Antigen prevalence among individuals who were systematically noncompliant with the MDAs, i.e. they had never participated, was significantly higher than among compliant individuals (p<0.05. A logistic regression model found that of the factors examined for association with infection, only noncompliance was significantly associated with infection. Thus, continuing transmission of LF seems

Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.

Science.gov (United States)

Chu, Brian K; Deming, Michael; Biritwum, Nana-Kwadwo; Bougma, Windtaré R; Dorkenoo, Améyo M; El-Setouhy, Maged; Fischer, Peter U; Gass, Katherine; Gonzalez de Peña, Manuel; Mercado-Hernandez, Leda; Kyelem, Dominique; Lammie, Patrick J; Flueckiger, Rebecca M; Mwingira, Upendo J; Noordin, Rahmah; Offei Owusu, Irene; Ottesen, Eric A; Pavluck, Alexandre; Pilotte, Nils; Rao, Ramakrishna U; Samarasekera, Dilhani; Schmaedick, Mark A; Settinayake, Sunil; Simonsen, Paul E; Supali, Taniawati; Taleo, Fasihah; Torres, Melissa; Weil, Gary J; Won, Kimberly Y

2013-01-01

Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low enough that it cannot be sustained even in the absence of drug intervention. Guidelines advanced by WHO call for a transmission assessment survey (TAS) to determine if MDA can be stopped within an LF evaluation unit (EU) after at least five effective rounds of annual treatment. To test the value and practicality of these guidelines, a multicenter operational research trial was undertaken in 11 countries covering various geographic and epidemiological settings. The TAS was conducted twice in each EU with TAS-1 and TAS-2 approximately 24 months apart. Lot quality assurance sampling (LQAS) formed the basis of the TAS survey design but specific EU characteristics defined the survey site (school or community), eligible population (6-7 year olds or 1(st)-2(nd) graders), survey type (systematic or cluster-sampling), target sample size, and critical cutoff (a statistically powered threshold below which transmission is expected to be no longer sustainable). The primary diagnostic tools were the immunochromatographic (ICT) test for W. bancrofti EUs and the BmR1 test (Brugia Rapid or PanLF) for Brugia spp. EUs. In 10 of 11 EUs, the number of TAS-1 positive cases was below the critical cutoff, indicating that MDA could be stopped. The same results were found in the follow-up TAS-2, therefore, confirming the previous decision outcome. Sample sizes were highly sex and age-representative and closely matched the target value after factoring in estimates of non-participation. The TAS was determined to be a practical and effective evaluation tool for stopping MDA although its validity for longer-term post-MDA surveillance requires further investigation.

Significant decline in lymphatic filariasis associated with nationwide scale-up of insecticide-treated nets in Zambia

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M. Nsakashalo-Senkwe

2017-11-01

Full Text Available Lymphatic filariasis (LF is a mosquito-borne disease, broadly endemic in Zambia, and is targeted for elimination by mass drug administration (MDA of albendazole and diethylcarbamazine citrate (DEC to at-risk populations. Anopheline mosquitoes are primary vectors of LF in Africa, and it is possible that the significant scale-up of malaria vector control over the past decade may have also impacted LF transmission, and contributed to a decrease in prevalence in Zambia. We therefore aimed to examine the putative association between decreasing LF prevalence and increasing coverage of insecticide-treated mosquito nets (ITNs for malaria vector control, by comparing LF mapping data collected between 2003–2005 and 2009–2011 to LF sentinel site prevalence data collected between 2012 and 2014, before any anti-LF MDA was started. The coverage of ITNs for malaria was quantified and compared for each site in relation to the dynamics of LF. We found a significant decrease in LF prevalence from the years 2003–2005 (11.5% CI95 6.6; 16.4 to 2012–2014 (0.6% CI95 0.03; 1.1; at the same time, there was a significant scale-up of ITNs across the country from 0.2% (CI95 0.0; 0.3 to 76.1% (CI95 71.4; 80.7 respectively. The creation and comparison of two linear models demonstrated that the geographical and temporal variation in ITN coverage was a better predictor of LF prevalence than year alone. Whilst a causal relationship between LF prevalence and ITN coverage cannot be proved, we propose that the scale-up of ITNs has helped to control Anopheles mosquito populations, which have in turn impacted on LF transmission significantly before the scale-up of MDA. This putative synergy with vector control has helped to put Zambia on track to meet national and global goals of LF elimination by 2020.

Female Principals in Education: Breaking the Glass Ceiling in Spain

Directory of Open Access Journals (Sweden)

Enrique Javier Diez Gutierrez

Full Text Available Abstract Spanish schools are characterised by having a high proportion of female staff. However, statistics show that a proportionately higher number of men hold leadership positions. The aim of this study was to analyse the reasons why this is so, and to determine the motivations and barriers that women encounter in attaining and exercising these positions of greater responsibility and power. Questionnaires were administered to 2,022 female teachers, 430 female principals and 322 male principals. In addition, semi-structured interviews were held with 60 female principals, 14 focus group discussions were held with female principals and 16 autobiographical narratives were compiled with female principals and school inspectors. The reasons identified were related to structural aspects linked to the patriarchal worldview that is still dominant in our society and culture. Nevertheless, we also found motivations among women for attaining and exercising leadership roles.

Twins and Kindergarten Separation: Divergent Beliefs of Principals, Teachers, Parents, and Twins

Science.gov (United States)

Gordon, Lynn Melby

2015-01-01

Should principals enforce mandatory separation of twins in kindergarten? Do school separation beliefs of principals differ from those of teachers, parents of twins, and twins themselves? This survey questioned 131 elementary principals, 54 kindergarten teachers, 201 parents of twins, and 112 twins. A majority of principals (71%) believed that…

78 FR 59383 - Principal Management Corporation, et al.; Notice of Application

Science.gov (United States)

2013-09-26

... sections 12(d)(1)(A) and (B) of the Act. Applicants: Principal Management Corporation (``PMC''), Principal... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30692; 812-14136] Principal Management Corporation, et al.; Notice of Application September 20, 2013. AGENCY: Securities and Exchange...

Sparse logistic principal components analysis for binary data

KAUST Repository

Lee, Seokho

2010-09-01

We develop a new principal components analysis (PCA) type dimension reduction method for binary data. Different from the standard PCA which is defined on the observed data, the proposed PCA is defined on the logit transform of the success probabilities of the binary observations. Sparsity is introduced to the principal component (PC) loading vectors for enhanced interpretability and more stable extraction of the principal components. Our sparse PCA is formulated as solving an optimization problem with a criterion function motivated from a penalized Bernoulli likelihood. A Majorization-Minimization algorithm is developed to efficiently solve the optimization problem. The effectiveness of the proposed sparse logistic PCA method is illustrated by application to a single nucleotide polymorphism data set and a simulation study. © Institute ol Mathematical Statistics, 2010.

Predicting the current and future potential distributions of lymphatic filariasis in Africa using maximum entropy ecological niche modelling.

Directory of Open Access Journals (Sweden)

Hannah Slater

Full Text Available Modelling the spatial distributions of human parasite species is crucial to understanding the environmental determinants of infection as well as for guiding the planning of control programmes. Here, we use ecological niche modelling to map the current potential distribution of the macroparasitic disease, lymphatic filariasis (LF, in Africa, and to estimate how future changes in climate and population could affect its spread and burden across the continent. We used 508 community-specific infection presence data collated from the published literature in conjunction with five predictive environmental/climatic and demographic variables, and a maximum entropy niche modelling method to construct the first ecological niche maps describing potential distribution and burden of LF in Africa. We also ran the best-fit model against climate projections made by the HADCM3 and CCCMA models for 2050 under A2a and B2a scenarios to simulate the likely distribution of LF under future climate and population changes. We predict a broad geographic distribution of LF in Africa extending from the west to the east across the middle region of the continent, with high probabilities of occurrence in the Western Africa compared to large areas of medium probability interspersed with smaller areas of high probability in Central and Eastern Africa and in Madagascar. We uncovered complex relationships between predictor ecological niche variables and the probability of LF occurrence. We show for the first time that predicted climate change and population growth will expand both the range and risk of LF infection (and ultimately disease in an endemic region. We estimate that populations at risk to LF may range from 543 and 804 million currently, and that this could rise to between 1.65 to 1.86 billion in the future depending on the climate scenario used and thresholds applied to signify infection presence.

Impact of community-based lymphedema management on perceived disability among patients with lymphatic filariasis in Orissa State, India.

Directory of Open Access Journals (Sweden)

Philip J Budge

Full Text Available Lymphatic filariasis (LF infects approximately 120 million people worldwide. As many as 40 million have symptoms of LF disease, including lymphedema, elephantiasis, and hydrocele. India constitutes approximately 45% of the world's burden of LF. The Indian NGO Church's Auxiliary for Social Action (CASA has been conducting a community-based lymphedema management program in Orissa State since 2007 that aims to reduce the morbidity associated with lymphedema and elephantiasis. The objective of this analysis is to evaluate the effects of this program on lymphedema patients' perceived disability.For this prospective cohort study, 370 patients ≥14 years of age, who reported lymphedema lasting more than three months in one or both legs, were recruited from villages in the Bolagarh sub-district, Khurda District, Orissa, India. The World Health Organization Disability Assessment Schedule II was administered to participants at baseline (July, 2009, and then at regular intervals through 24 months (July, 2011, to assess patients' perceived disability. Disability scores decreased significantly (p<0.0001 from baseline to 24 months. Multivariable analysis using mixed effects modeling found that employment and time in the program were significantly associated with lower disability scores after two years of program involvement. Older age, female gender, the presence of other chronic health conditions, moderate (Stage 3 or advanced (Stage 4-7 lymphedema, reporting an adenolymphangitis (ADL episode during the previous 30 days, and the presence of inter-digital lesions were associated with higher disability scores. Patients with moderate or advanced lymphedema experienced greater improvements in perceived disability over time. Patients participating in the program for at least 12 months also reported losing 2.5 fewer work days per month (p<0.001 due to their lymphedema, compared to baseline.These results indicate that community-based lymphedema management programs

Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs.

Directory of Open Access Journals (Sweden)

Paul T Cantey

2010-06-01

Full Text Available Nearly 45% of people living at risk for lymphatic filariasis (LF worldwide live in India. India has faced challenges obtaining the needed levels of compliance with its mass drug administration (MDA program to interrupt LF transmission, which utilizes diethylcarbamazine (DEC or DEC plus albendazole. Previously identified predictors of and barriers to compliance with the MDA program were used to refine a pre-MDA educational campaign. The objectives of this study were to assess the impact of these refinements and of a lymphedema morbidity management program on MDA compliance.A randomized, 30-cluster survey was performed in each of 3 areas: the community-based pre-MDA education plus community-based lymphedema management education (Com-MDA+LM area, the community-based pre-MDA education (Com-MDA area, and the Indian standard pre-MDA education (MDA-only area. Compliance with the MDA program was 90.2% in Com-MDA+LM, 75.0% in Com-MDA, and 52.9% in the MDA-only areas (p<0.0001. Identified barriers to adherence included: 1 fear of side effects and 2 lack of recognition of one's personal benefit from adherence. Multivariable predictors of adherence amenable to educational intervention were: 1 knowing about the MDA in advance of its occurrence, 2 knowing everyone is at risk for LF, 3 knowing that the MDA was for LF, and 4 knowing at least one component of the lymphedema management techniques taught in the lymphedema management program.This study confirmed previously identified predictors of and barriers to compliance with India's MDA program for LF. More importantly, it showed that targeting these predictors and barriers in a timely and clear pre-MDA educational campaign can increase compliance with MDA programs, and it demonstrated, for the first time, that lymphedema management programs may also increase compliance with MDA programs.

Setting Instructional Expectations: Patterns of Principal Leadership for Middle School Mathematics

Science.gov (United States)

Katterfeld, Karin

2013-01-01

Principal instructional leadership has been found to support improved instruction. However, the methods through which principal leadership influences classroom instruction are less clear. This study investigates how principals' leadership may predict the expectations that mathematics teachers perceive for classroom practice. Results from a…

A Principal-Agent Analysis of the Family: Implications for the Welfare State

OpenAIRE

Munro, Lauchlan

1999-01-01

The principal-agent literature has focussed on situations where both principal and agent are assumed to be capable of defining and defending their own interests. The principal-agent literature has thus ignored an important set of cases where the principal is incapable of acting on her own behalf, and so is assigned an agent by law or custom. Such cases account for around 40% of humanity and for a similarly substantial proportion of all principal-agent interactions. This paper applies principa...

A Tannakian approach to dimensional reduction of principal bundles

Science.gov (United States)

Álvarez-Cónsul, Luis; Biswas, Indranil; García-Prada, Oscar

2017-08-01

Let P be a parabolic subgroup of a connected simply connected complex semisimple Lie group G. Given a compact Kähler manifold X, the dimensional reduction of G-equivariant holomorphic vector bundles over X × G / P was carried out in Álvarez-Cónsul and García-Prada (2003). This raises the question of dimensional reduction of holomorphic principal bundles over X × G / P. The method of Álvarez-Cónsul and García-Prada (2003) is special to vector bundles; it does not generalize to principal bundles. In this paper, we adapt to equivariant principal bundles the Tannakian approach of Nori, to describe the dimensional reduction of G-equivariant principal bundles over X × G / P, and to establish a Hitchin-Kobayashi type correspondence. In order to be able to apply the Tannakian theory, we need to assume that X is a complex projective manifold.

Longitudinal functional principal component modelling via Stochastic Approximation Monte Carlo

KAUST Repository

Martinez, Josue G.

2010-06-01

The authors consider the analysis of hierarchical longitudinal functional data based upon a functional principal components approach. In contrast to standard frequentist approaches to selecting the number of principal components, the authors do model averaging using a Bayesian formulation. A relatively straightforward reversible jump Markov Chain Monte Carlo formulation has poor mixing properties and in simulated data often becomes trapped at the wrong number of principal components. In order to overcome this, the authors show how to apply Stochastic Approximation Monte Carlo (SAMC) to this problem, a method that has the potential to explore the entire space and does not become trapped in local extrema. The combination of reversible jump methods and SAMC in hierarchical longitudinal functional data is simplified by a polar coordinate representation of the principal components. The approach is easy to implement and does well in simulated data in determining the distribution of the number of principal components, and in terms of its frequentist estimation properties. Empirical applications are also presented.

Probabilistic Principal Component Analysis for Metabolomic Data.

LENUS (Irish Health Repository)

Nyamundanda, Gift

2010-11-23

Abstract Background Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique for analyzing metabolomic data. However, PCA is limited by the fact that it is not based on a statistical model. Results Here, probabilistic principal component analysis (PPCA) which addresses some of the limitations of PCA, is reviewed and extended. A novel extension of PPCA, called probabilistic principal component and covariates analysis (PPCCA), is introduced which provides a flexible approach to jointly model metabolomic data and additional covariate information. The use of a mixture of PPCA models for discovering the number of inherent groups in metabolomic data is demonstrated. The jackknife technique is employed to construct confidence intervals for estimated model parameters throughout. The optimal number of principal components is determined through the use of the Bayesian Information Criterion model selection tool, which is modified to address the high dimensionality of the data. Conclusions The methods presented are illustrated through an application to metabolomic data sets. Jointly modeling metabolomic data and covariates was successfully achieved and has the potential to provide deeper insight to the underlying data structure. Examination of confidence intervals for the model parameters, such as loadings, allows for principled and clear interpretation of the underlying data structure. A software package called MetabolAnalyze, freely available through the R statistical software, has been developed to facilitate implementation of the presented methods in the metabolomics field.

Burnout And Lifestyle Of Principals And Entrepreneurs

Directory of Open Access Journals (Sweden)

Jasna Lavrenčič

2014-12-01

Full Text Available Research Question (RQ: What kind of lifestyle do the principals and entrepreneurs lead? Does the lifestyle of principals and entrepreneurs influence burnout? Purpose: To find out, based on the results of a questionnaire, what kind of lifestyle both researched groups lead. Does lifestyle have an influence on the occurrence of the phenomenon of burnout. Method: We used the method of data collection by questionnaire. Acquired data were analyzed using SPSS, descriptive and inference statistics. Results: Results showed, that both groups lead a similar lifestyle and that lifestyle influences burnout with principals, as well as entrepreneurs. Organization: School principals and entrepreneurs are the heads of individual organizations or companies, the goal of which is success. To be successful in their work, they must adapt their lifestyle, which can be healthy or unhealthy. If their lifestyle is unhealthy, it can lead to burnout. Society: With results of the questionnaire we would like to answer the question about the lifestyle of both groups and its influence on the occurrence of burnout. Originality: The study of lifestyle and the occurrence of burnout in these two groups is the first study in this area. Limitations/Future Research: In continuation, research groups could be submitted to the research fields of effort physiology and tracking of certain haematological parameters, such as cholesterol, blood sugar and stress hormones - adrenaline, noradrenalin, cortisol. Thus, we could carry out an even more in depth research of the connection between lifestyle and burnout.

26 CFR 301.6226(a)-1 - Principal place of business of partnership.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Principal place of business of partnership. 301... Principal place of business of partnership. (a) In general. The principal place of a partnership's business... partnership items may be filed is its principal place of business as of the date the petition is filed. (b...

Maintaining effective mass drug administration for lymphatic filariasis through in-process monitoring in Sierra Leone

Directory of Open Access Journals (Sweden)

Hodges Mary H

2012-10-01

Full Text Available Abstract Background Since 2007 Sierra Leone has conducted mass drug administration (MDA for the elimination of lymphatic filariasis (LF implemented by unpaid community health volunteers (CHVs. Other health campaigns such as Mother and Child Health Weeks (MCHW pay for services to be implemented at community level and these persons are then known as community health workers (CHWs. In 2010, the LF MDA in the 12 districts of the Southern, Northern and Eastern Provinces un-expectantly coincided with universal distribution of Long Lasting Insecticide Treated Nets (LLITNs during the MCHW. In-process monitoring of LF MDA was performed to ensure effective coverage was attained in hard to reach sites (HTR in both urban and rural locations where vulnerable populations reside. Methods Independent monitors interviewed individuals eligible for LF MDA and tallied those who recalled having taken ivermectin and albendazole, calculated program coverage and reported results daily by phone. Monitoring of coverage in HTR sites in the 4 most rapidly urbanizing towns was performed after 4 weeks of LF MDA and again after 8 weeks throughout all 12 districts. End process monitoring was performed in randomly selected HTR sites not previously sampled throughout all 12 districts and compared to coverage calculated from the pre-MDA census and reported treatments. Results Only one town had reached effective program coverage (≥80% after 4 weeks following which CHWs were recruited for LF MDA in all district headquarter towns. After 8 weeks only 4 of 12 districts had reached effective coverage so LF MDA was extended for a further month in all districts. By 12 weeks effective program coverage had been reached in all districts except Port Loko and there was no significant difference between those interviewed in communities versus households or by sex. Effective epidemiological coverage (≥65% was reported in all districts and overall was significantly higher in males versus

Toward Instructional Leadership: Principals' Perceptions of Large-Scale Assessment in Schools

Science.gov (United States)

Prytula, Michelle; Noonan, Brian; Hellsten, Laurie

2013-01-01

This paper describes a study of the perceptions that Saskatchewan school principals have regarding large-scale assessment reform and their perceptions of how assessment reform has affected their roles as principals. The findings revealed that large-scale assessments, especially provincial assessments, have affected the principal in Saskatchewan…

Instructional Leadership Responsibilities of Assistant Principals in Large Texas High Schools

Science.gov (United States)

Howard-Schwind, Michelle

2010-01-01

The purpose of this study was to determine the extent secondary assistant principals in large Texas high schools demonstrate behaviors consistent with what the literature describes as instructional leadership. Three hundred seventy principals and assistant principals of large Texas high schools participated in this study. The Principal…

Comment 2 on workshop in political institutions - principal-agent relationships

International Nuclear Information System (INIS)

Feeny, D.

1992-01-01

In recent decades, economic analysis has been extended to situations in which there are important asymmetries of information between actors. One important class of these situations are principal-agent relationships, in which one party, the agent, acts on behalf of the other, the principal. In such situations of incomplete and asymmetric information (in which the agent may be better informed than the principal), is it possible to devise mechanisms to ensure that the agent acts in the best interests of the principal? How can we construct relationships so that physicians act in the best interests of patients, lawyer in the best interests of their clients, or public officials in the best interests of their constituents?

The experiences of female principals on curriculum leadership in ...

African Journals Online (AJOL)

Gender and Behaviour ... women have managed curriculum implementation in secondary schools in order to inform both policy makers, school principals and scholars of gender studies about good practices from ... The study found that: One, these principals possessed social skills, such as warmth and strong relationships.

Collusion and Renegotiation in a Principal-Supervisor-Agent Relationship

NARCIS (Netherlands)

Strausz, R.G.

1995-01-01

This paper describes a principal-agent relationship with a supervisor who has information about the agent. The agent and the supervisor have the possibility to collude and misinform the principal. From the literature we know that there exists an optimal contract which excludes collusion in

Constrained principal component analysis and related techniques

CERN Document Server

Takane, Yoshio

2013-01-01

In multivariate data analysis, regression techniques predict one set of variables from another while principal component analysis (PCA) finds a subspace of minimal dimensionality that captures the largest variability in the data. How can regression analysis and PCA be combined in a beneficial way? Why and when is it a good idea to combine them? What kind of benefits are we getting from them? Addressing these questions, Constrained Principal Component Analysis and Related Techniques shows how constrained PCA (CPCA) offers a unified framework for these approaches.The book begins with four concre

Teachers' Perspectives of the Principals' Invitational Leadership Behaviors, Teacher Job Satisfaction and Principal Effectiveness in High-Poverty Rural Elementary Schools

Science.gov (United States)

Younis, Matthew Christopher Zadin

2017-01-01

The purpose of this study was to examine the impact of Invitational Leadership behaviors on school teacher satisfaction, teacher perceptions of the school principal's performance, and to identify if there was a difference between the levels of inviting behaviors of principals at high-achieving and low-achieving rural schools in North Carolina. The…

Stepping Stones: Principal Career Paths and School Outcomes. Working Paper 58

Science.gov (United States)

Beteille, Tara; Kalogrides, Demetra; Loeb, Susanna

2011-01-01

Principals tend to prefer working in schools with higher-achieving students from more advantaged socioeconomic backgrounds. Principals often use schools with many poor or low-achieving students as stepping stones to what they view as more desirable assignments. District leadership can also exacerbate principal turnover by implementing policies…

Assessing Principals' Quality Assurance Strategies in Osun State Secondary Schools, Nigeria

Science.gov (United States)

Fasasi, Yunus Adebunmi; Oyeniran, Saheed

2014-01-01

This paper examined principals' quality assurance strategies in secondary schools in Osun State, Nigeria. The study adopted a descriptive survey research design. Stratified random sampling technique was used to select 10 male and 10 female principals, and 190 male and190 female teachers. "Secondary School Principal Quality Assurance…

Career Status of Secondary Principals in Small Schools in the Southwest.

Science.gov (United States)

Seifert, Edward H.

1985-01-01

A random sample of 559 secondary small school principals in Arkansas, Colorado, New Mexico, Oklahoma, and Texas revealed that 73 percent of the principals were actively seeking new positions or were leaving school administration. The findings have implications for selection procedures, salary/fringe benefit packages, principal autonomy, evaluation…

School Principals' Assumptions about Human Nature: Implications for Leadership in Turkey

Science.gov (United States)

Sabanci, Ali

2008-01-01

This article considers principals' assumptions about human nature in Turkey and the relationship between the assumptions held and the leadership style adopted in schools. The findings show that school principals hold Y-type assumptions and prefer a relationship-oriented style in their relations with assistant principals. However, both principals…

The Motivating Language of Principals: A Sequential Transformative Strategy

Science.gov (United States)

Holmes, William Tobias

2012-01-01

This study implemented a Sequential Transformative Mixed Methods design with teachers (as recipients) and principals (to give voice) in the examination of principal talk in two different school accountability contexts (Continuously Improving and Continuously Zigzag) using the conceptual framework of Motivating Language Theory. In phase one,…

Empowering Teachers: Characteristics, Strategies, and Practices of Successful Principals

Science.gov (United States)

Ellis, Cailin Patrice

2012-01-01

This study implemented an exploratory mixed-methods design to better understand how the characteristics of a principal, specifically the strategies, behaviors, and actions, lead to the perception of empowerment as perceived by the teachers themselves. An expert panel identified three "highly successful" principals assigned to elementary…

School Uniforms: Guidelines for Principals.

Science.gov (United States)

Essex, Nathan L.

2001-01-01

Principals desiring to develop a school-uniform policy should involve parents, teachers, community leaders, and student representatives; beware restrictions on religious and political expression; provide flexibility and assistance for low-income families; implement a pilot program; align the policy with school-safety issues; and consider legal…

The principal radionuclides in high level radioactive waste management

International Nuclear Information System (INIS)

Mulyanto

1998-01-01

The principal radionuclides in high level radioactive waste management. The selection of the principal radionuclides in the high level waste (HLW) management was developed in order to improve the disposal scenario of HLW. In this study the unified criteria for selection of the principal radionuclides were proposed as; (1) the value of hazard index estimated by annual limit of intake (ALI) for long-term tendency,(2) the relative dose factor related to adsorbed migration rate transferred by ground water, and (3) heat generation in the repository. From this study it can be concluded that the principal radionuclides in the HLW management were minor actinide (MA=Np, Am, Cm, etc), Tc, I, Cs and Sr, based on the unified basic criteria introduced in this study. The remaining short-lived fission product (SLFPs), after the selected nuclides are removed, should be immobilized and solidified in a glass matrix. Potential risk due to the remaining SLFPs can be lower than that of uranium ore after about 300 year. (author)

Knowledge and Professional Development for Principals Leading Linguistic Communities in Schools

Science.gov (United States)

Vidal-Butler, Stacey Lynn

2017-01-01

The role of the school principal is demanding in a variety of ways. School principals are faced with the daily challenge of balancing their roles of site manager and instructional leader. This study examined and identified the knowledge and learning opportunities school principals rely upon to lead schools, particularly those that lead schools…

The Job Realities of Beginning and Experienced Assistant Principals

Science.gov (United States)

Barnett, Bruce G.; Shoho, Alan R.; Oleszewski, Ashley M.

2012-01-01

This study examined the perceptions of a cross section of new and experienced assistant principals regarding the realities of their jobs. Findings indicated that their challenges pertain to workload and task management, conflicts with adults and students, and curriculum and instruction issues. Novice and experienced assistant principals' responses…

Ecstasy of Emptiness? Reflections of a Retired School Principal.

Science.gov (United States)

Azzara, Judith R.

2001-01-01

A retired elementary principal who was actively tied to her community for decades explains how to put a positive spin on retirement. New retirees should treasure their gifts and talents, develop new ones, take advantage of travel opportunities, mentor a new principal, and/or go back to college. (MLH)

75 FR 82236 - Principal Trades with Certain Advisory Clients

Science.gov (United States)

2010-12-30

... 3235-AJ96 Principal Trades with Certain Advisory Clients AGENCY: Securities and Exchange Commission... certain of their advisory clients. The amendment extends the date on which rule 206(3)- 3T will sunset... a principal capacity in transactions with certain of their advisory clients.\\1\\ In December 2009, we...

Rural Rides in Queensland: Travels with Novice Teaching Principals

Science.gov (United States)

Clarke, Simon; Stevens, Elizabeth; Wildy, Helen

2006-01-01

This article is concerned with the nature of novice teaching principals' interactions in Queensland rural communities. Stories selected from case accounts are used to provide insights into the teaching principals' interrelationship with the community. The article concludes with a discussion of some implications for practice suggested by these…

The Technology Principal: To Be or Not to Be?

Science.gov (United States)

Anthony, Anika Ball; Patravanich, Supawaree

2014-01-01

This case provides principal licensure candidates a strategic perspective on leading and managing educational technology initiatives. It presents issues related to vision setting, planning, implementation, organizational structure, and decision making. The case narrative is presented from the perspective of a principal, but it can also be used to…

Importing a Culture of Success Via a Strong Principal.

Science.gov (United States)

Reavis, Charles A.; Vinson, David; Fox, Richard

1999-01-01

Examines how a new principal at a historically low-performing high school brought about changes in the school culture and in student achievement. Describes how the principal emphasized achievement at the highest levels through heroes and heroines, rites and rituals, stories, governance and leadership, symbols, enforcing expectations, and serving…

Teachers' Perspectives on Principal Mistreatment

Science.gov (United States)

Blase, Joseph; Blase, Jo

2006-01-01

Although there is some important scholarly work on the problem of workplace mistreatment/abuse, theoretical or empirical work on abusive school principals is nonexistent. Symbolic interactionism was the theoretical structure for the present study. This perspective on social research is founded on three primary assumptions: (1) individuals act…

Plasmodium knowlesi and Wucheriria bancrofti: Their vectors and challenges for the future

Directory of Open Access Journals (Sweden)

Indra eVythilingam

2012-05-01

Full Text Available Malaria and filariasis still continue to pose public health problems in developing countries of the tropics. Although plans are ongoing for the elimination of both these parasitic vector borne diseases, we are now faced with a daunting challenge as we have a fifth species, Plasmodium knowlesi a simian malaria parasite affecting humans. Similarly in peninsular Malaysia, filariasis was mainly due to Brugia malayi, however, we now see cases of W. bancrofti in immigrant workers coming into the country. Work is on going to eliminate malaria and filariasis from the country. In order to be successful we need to revamp our control measures. Thus this paper attempts to review the vectors of malaria and filariasis in Southeast Asia with special emphasis on P. knowlesi and W. bancrofti and their control strategies.

Principal Perceptions of the Effectiveness of University Educational Leadership Preparation and Professional Learning

Science.gov (United States)

Johnson, Arvin D.

2016-01-01

Principals and assistant principals currently serving in Florida and Georgia school districts were surveyed about their perceptions of university educational leadership preparation and professional learning. The results revealed that many principals and assistant principals agreed that university educational leadership preparation programs…

A New "Principal Principle" (#14) of Physical Activity Education Is Emerging

Science.gov (United States)

Zeigler, Earle F.

2011-01-01

There is every reason to believe that a new "principal principle" of physical activity education is emerging. In this article, the author talks about the new "principal principle"(#14) of physical education. Revisiting a historical milestone in the field's history to explain the origin of the term "principal principle," Dr. Arthur H. Steinhaus,…

Principal permeability determination from multiple horizontal well tests

Energy Technology Data Exchange (ETDEWEB)

Economides, M. [Texas A and M Univ., TX (United States); Munoz, A.; Ehlig-Economides, C.

1998-12-31

A method for obtaining principal permeability magnitudes and direction that requires only the linear flow regime from transient tests in three horizontal wells oriented in three distinct and arbitrary directions, is described. Well design optimization strategies require knowledge of both the principal permeability orientation as well as the horizontal permeability magnitudes. When the degree of horizontal permeability anisotropy (i.e. permeability in the bedding plane with respect to direction) is significant, the productivity of a long horizontal well will depend greatly on its direction, especially when the well is first brought into production. Productivities have been found to deviate substantially among wells in the same reservoir and this deviation has been attributed to differences in well orientation. In view of this fact, measuring permeability anisotropy becomes a compelling necessity. The success of the proposed method is illustrated by a case study in which the principal permeability magnitudes and direction from three wells were used to predict the productivity of a fourth well within 10 per cent. Use of the computed principal permeabilities from the case study, it was possible to forecast the cumulative production to show the significance of well trajectory optimization on the discounted cash flow and the net present value. 20 refs., 3 figs.

Invisible Barriers: The Loneliness of School Principals at Turkish ...

African Journals Online (AJOL)

Psychological insight is the notion that all participants agreed on and emphasised when asked to offer a definition of loneliness at schools. Participants also agreed on the fact that the organisational climate at Turkish schools represented the most significant reason for principals' loneliness at work. The school principals that ...

40 CFR 14.12 - Principal types of unallowable claims.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Principal types of unallowable claims... PERSONAL PROPERTY CLAIMS § 14.12 Principal types of unallowable claims. Claims that ordinarily will not be... valid appraisal or authentication with the carrier prior to shipment of the item; (d) Loss of bankbooks...

Teacher-Principal Race and Teacher Satisfaction over Time, Region

Science.gov (United States)

Viano, Samantha L.; Hunter, Seth B.

2017-01-01

Purpose: The purpose of this paper is to replicate prior findings on teacher-principal race congruence and teacher job satisfaction and extend the literature by investigating trends over time and if the relationship between race congruence and teacher job satisfaction differs by principal race and region. Design/methodology/approach: The study…

Social Media Arrive in School; Principals Look at Impacts

Science.gov (United States)

Armistead, Lew

2010-01-01

Social media have the potential to improve educational opportunities for high school students, but also present legal and policy challenges for public school principals. Those were among opinions expressed in the 2010 Principals' Partnership Poll. The most frequently-cited request by the 306 respondents was help in integrating social media into…

The Relationship Among Principal Preparation Programs, Professional Development, and Instructional Leadership Efficacy  

OpenAIRE

Thomas III, Harry R.

2015-01-01

This study presents a qualitative analysis of principals' perceptions of the relationship among principal preparation programs, professional development and instructional leadership confidence in one urban school division in Virginia. Levine (2005) argued that the principal has a salient effect on the instructional programs within schools, and the preparation and professional development of the principal affects the degree to which they maintain and improve instruction. To examine principal p...

Computing Cumulative Interest and Principal Paid For a Calendar Year

OpenAIRE

John O. MASON

2011-01-01

This paper demonstrates how easy it is use Microsoft Excel’s CUMPRINC and CUMIPMT functions to compute principal and interest paid for an entire year, even though the payments were made monthly. The CUMPRINC function computes the principal paid by a series of loan payments; the CUMIPMT function computes the interest paid. These two functions provide an alternative to preparing a monthly loan amortization schedule and adding up the amounts of monthly interest paid and principal paid for the ye...

Practices of Elementary Principals in Influencing New Teachers to Remain in Education

OpenAIRE

Palermo, Thelma D.

2002-01-01

The grounded theory presented in this study describes practices elementary principals utilize in influencing new teachers to remain in education. Eleven teachers and three elementary principals from one school division in Virginia participated in this study. Interview data were collected, elementary principals were shadowed, and documents were analyzed. Thematic categories and sub categories were formed through data analysis. The grounded theory that resulted from this study is: principals wh...

An Introductory Application of Principal Components to Cricket Data

Science.gov (United States)

Manage, Ananda B. W.; Scariano, Stephen M.

2013-01-01

Principal Component Analysis is widely used in applied multivariate data analysis, and this article shows how to motivate student interest in this topic using cricket sports data. Here, principal component analysis is successfully used to rank the cricket batsmen and bowlers who played in the 2012 Indian Premier League (IPL) competition. In…

Financial accountability: the principal or the school governing body ...

African Journals Online (AJOL)

The Schools Act 84 of 1996 prescribes how a school should manage its funds. It also provides guidelines for the school governing body and the principal on their roles and responsibilities in managing the finances of the school. However, there are school governing bodies and principals that have little knowledge of the ...

Prolonged persistence of residual Wuchereria bancrofti infection after cessation of diethylcarbamazine-fortified salt programme.

Science.gov (United States)

Ramaiah, K D; Thiruvengadam, B; Vanamail, P; Subramanian, S; Gunasekaran, S; Nilamani, N; Das, P K

2009-08-01

A diethylcarbamazine (DEC)-fortified salt intervention programme was implemented between 1982 and 1986 in Karaikal district, Union territory of Pondicherry, south India, to control Culex transmitted bancroftian filariasis. The intervention reduced the microfilaria (Mf) rate from 4.49% to 0.08%. To eliminate the residual microfilaraemia, the health department detected and treated Mf carriers from 1987 to 2005 and mass-administered drugs in 2004 and 2005. Surveillance from 1987 to 2005 revealed persistent microfilaraemia in 0.03-0.42% of the population. In 2006, we conducted a more detailed Mf survey and a child antigenaemia (Ag) survey in 15 urban wards and 17 rural villages. These surveys showed an overall Mf rate of 0.46% in the high-risk urban areas and 0.18% in the rural areas; none of the sampled children was positive for Ag. All detected Mf carriers were >20 years old. The age of the youngest Mf carrier was 30 years in urban and 21 years in rural areas, which suggests that transmission was interrupted and there was no incidence of new Mf case after cessation of DEC salt programme. Eleven of 15 urban and 15 of 17 villages were totally free from microfilaraemia. Nevertheless, three of 15 surveyed urban localities and two of 17 villages showed >1% Mf rate. Thus, it seems that (i) post-intervention very low levels of microfilaraemia can continue as long as 20 years; (ii) 0.60-0.70% Mf rate is a safe level and at this level recrudescence of infection may not occur; (iii) there can be isolated localities with >1% Mf rate and their detection for further intervention measures could be challenging in larger control/elimination programmes and (iv) the residual infection mostly gets concentrated in the adult population, in underdeveloped urban areas and in historically highly endemic or large endemic rural areas. These groups and areas should be targeted with rigorous intervention measures such as mass drug administration to eliminate the residual infection.

Insecticide resistance in disease vectors from Mayotte: an opportunity for integrated vector management.

Science.gov (United States)

Pocquet, Nicolas; Darriet, Frédéric; Zumbo, Betty; Milesi, Pascal; Thiria, Julien; Bernard, Vincent; Toty, Céline; Labbé, Pierrick; Chandre, Fabrice

2014-07-01

Mayotte, a small island in the Indian Ocean, has been affected for many years by vector-borne diseases. Malaria, Bancroftian filariasis, dengue, chikungunya and Rift Valley fever have circulated or still circulate on the island. They are all transmitted by Culicidae mosquitoes. To limit the impact of these diseases on human health, vector control has been implemented for more than 60 years on Mayotte. In this study, we assessed the resistance levels of four major vector species (Anopheles gambiae, Culex pipiens quinquefasciatus, Aedes aegypti and Aedes albopictus) to two types of insecticides: i) the locally currently-used insecticides (organophosphates, pyrethroids) and ii) alternative molecules that are promising for vector control and come from different insecticide families (bacterial toxins or insect growth regulators). When some resistance was found to one of these insecticides, we characterized the mechanisms involved. Larval and adult bioassays were used to evaluate the level of resistance. When resistance was found, we tested for the presence of metabolic resistance through detoxifying enzyme activity assays, or for target-site mutations through molecular identification of known resistance alleles. Resistance to currently-used insecticides varied greatly between the four vector species. While no resistance to any insecticides was found in the two Aedes species, bioassays confirmed multiple resistance in Cx. p. quinquefasciatus (temephos: ~ 20 fold and deltamethrin: only 10% mortality after 24 hours). In An. gambiae, resistance was scarce: only a moderate resistance to temephos was found (~5 fold). This resistance appears to be due only to carboxyl-esterase overexpression and not to target modification. Finally, and comfortingly, none of the four species showed resistance to any of the new insecticides. The low resistance observed in Mayotte's main disease vectors is particularly interesting, because it leaves a range of tools useable by vector control

Microfilaria in pleural effusion: An unusual association

Directory of Open Access Journals (Sweden)

Rehena Sarkar

2016-01-01

Full Text Available Lymphatic filariasis is a major public health problem in tropical countries and India is endemic for it. However, lymphatic filariasis presenting as pleural effusion is an unusual manifestation and finding microfilaria in pleural effusion without any lung pathology is rare. We report a case of pleural effusion without any underlying lung pathology and normal blood picture. Clinical cure occurred after treatment with diethyl-carbamazepine. Filariasis should be kept in view while considering the differential diagnosis of idiopathic pleural effusion, especially in endemic countries.

Principal components analysis in clinical studies.

Science.gov (United States)

Zhang, Zhongheng; Castelló, Adela

2017-09-01

In multivariate analysis, independent variables are usually correlated to each other which can introduce multicollinearity in the regression models. One approach to solve this problem is to apply principal components analysis (PCA) over these variables. This method uses orthogonal transformation to represent sets of potentially correlated variables with principal components (PC) that are linearly uncorrelated. PCs are ordered so that the first PC has the largest possible variance and only some components are selected to represent the correlated variables. As a result, the dimension of the variable space is reduced. This tutorial illustrates how to perform PCA in R environment, the example is a simulated dataset in which two PCs are responsible for the majority of the variance in the data. Furthermore, the visualization of PCA is highlighted.

Becoming a Principal in Indonesia: Possibility, Pitfalls and Potential

Science.gov (United States)

Sumintono, Bambang; Sheyoputri, Elslee Y. A.; Jiang, Na; Misbach, Ifa H.; Jumintono

2015-01-01

The preparation and development of school leaders is now considered to be fundamental to school and system improvement. In the pursuit of educational change and reform, the leadership of the principal is deemed to be of critical importance. This qualitative study is part of a large scale research project that is exploring principal preparation and…

Principal Concerns: Iowa May Face Statewide Demand. Data Brief

Science.gov (United States)

DeArmond, Michael; Ouijdani, Monica

2012-01-01

When people talk about human capital or talent in public education, they generally focus on teachers, not principals. That's a mistake. School districts and states generally don't take a strategic approach toward managing their principal workforce. Often, they lack even the most basic information about who is leading their schools: Where do most…

The kinds of knowledge principals use: Implications for training

Directory of Open Access Journals (Sweden)

Angeliki Lazaridou

2009-01-01

Full Text Available Information about how school principals operate pertains mainly to the actions of principals. However, the kinds of knowledge that the principalship demands have not been isolated as clearly, more often than not being conflated with actions. As principals’ duties become more complex, it becomes more important to ground specific practices in robust knowledge of relevant theoretical principles. One aspect of the principal’s job where this is particularly germane is the resolution of unfamiliar, complex, unstructured challenges. This paper presents findings from research into how principals think when dealing with problematic situations, in particular the types of knowledge they use. Four broad categories of knowledge were identified and, within those, twelve specific types. The research lends credence to the oral report or think-aloud method for making thinking processes available for analysis, and the findings indicate how the content of preparation programs may be adjusted to better qualify principals for the contemporary demands of their work. A prime recommendation is the inclusion of opportunities for the development of tacit knowledge.

Optimal interface between principal deterrent systems and material accounting

International Nuclear Information System (INIS)

Deiermann, P.J.; Opelka, J.H.

1983-01-01

The purpose of this study is to find an optimal blend between three safeguards systems for special nuclear material (SNM), the material accounting system and the physical security and material control systems. The latter two are denoted as principal deterrent systems. The optimization methodology employed is a two-stage decision algorithm, first an explicit maximization of expected diverter benefits and subsequently a minimization of expected defender costs for changes in material accounting procedures and incremental improvements in the principal deterrent systems. The probability of diverter success function dependent upon the principal deterrents and material accounting system variables is developed. Within the range of certainty of the model, existing material accounting, material control and physical security practices are justified

Wavelet decomposition based principal component analysis for face recognition using MATLAB

Science.gov (United States)

Sharma, Mahesh Kumar; Sharma, Shashikant; Leeprechanon, Nopbhorn; Ranjan, Aashish

2016-03-01

For the realization of face recognition systems in the static as well as in the real time frame, algorithms such as principal component analysis, independent component analysis, linear discriminate analysis, neural networks and genetic algorithms are used for decades. This paper discusses an approach which is a wavelet decomposition based principal component analysis for face recognition. Principal component analysis is chosen over other algorithms due to its relative simplicity, efficiency, and robustness features. The term face recognition stands for identifying a person from his facial gestures and having resemblance with factor analysis in some sense, i.e. extraction of the principal component of an image. Principal component analysis is subjected to some drawbacks, mainly the poor discriminatory power and the large computational load in finding eigenvectors, in particular. These drawbacks can be greatly reduced by combining both wavelet transform decomposition for feature extraction and principal component analysis for pattern representation and classification together, by analyzing the facial gestures into space and time domain, where, frequency and time are used interchangeably. From the experimental results, it is envisaged that this face recognition method has made a significant percentage improvement in recognition rate as well as having a better computational efficiency.

High School Principals and the High School Journalism Program.

Science.gov (United States)

Peterson, Jane W.

A study asked selected high school principals to respond to statements about the value of high school journalism to the high school student and about the rights and responsibilities of the high school journalist. These responses were then checked against such information as whether or not the high school principal had worked on a high school…

On the principal state method for runlength limited sequences

NARCIS (Netherlands)

Tjalkens, T.J.

1994-01-01

Presents a detailed result on Franaszek's (1968) principal state method for the generation of run-length constrained codes. The authors show that, whenever the constraints k and d satisfy k 2d>0, the set of "principal states" is s0, s1, ···, sk-1. Thus there is no need for Franaszek's search

Using Concept Mapping to Build Concept the Competence of School Principals

Directory of Open Access Journals (Sweden)

Mustamin Mustamin

2012-08-01

Full Text Available More and more the competence concept of school principals have an impact on two conditions, namely: (1 to develop the concept can complement and support each other; and (2 to develop the concept of possible contradict, giving rise to different interpretations. Therefore, this becomes the main issue researchers to identify the competence concept of school principals with adaptation of Jackson-Trochim method that is capable of illustrating the concept of competencies. Results of adaptation Jackson-Trochim method that school principals should have three types of competencies to lead the school effectively and efficiently. Kind of competencies are such as school leadership, instructional leadership, and operational leadership. Based on these results, the adaptationof Jackson-Trochim method to build the competence concept of school principals suggests this concept obtained may serve as a reference for school principals continue to build competencies in the future

Sequential modelling of the effects of mass drug treatments on anopheline-mediated lymphatic filariasis infection in Papua New Guinea.

Directory of Open Access Journals (Sweden)

Brajendra K Singh

Full Text Available Lymphatic filariasis (LF has been targeted by the WHO for global eradication leading to the implementation of large scale intervention programs based on annual mass drug administrations (MDA worldwide. Recent work has indicated that locality-specific bio-ecological complexities affecting parasite transmission may complicate the prediction of LF extinction endpoints, casting uncertainty on the achievement of this initiative. One source of difficulty is the limited quantity and quality of data used to parameterize models of parasite transmission, implying the important need to update initially-derived parameter values. Sequential analysis of longitudinal data following annual MDAs will also be important to gaining new understanding of the persistence dynamics of LF. Here, we apply a Bayesian statistical-dynamical modelling framework that enables assimilation of information in human infection data recorded from communities in Papua New Guinea that underwent annual MDAs, into our previously developed model of parasite transmission, in order to examine these questions in LF ecology and control.Biological parameters underlying transmission obtained by fitting the model to longitudinal data remained stable throughout the study period. This enabled us to reliably reconstruct the observed baseline data in each community. Endpoint estimates also showed little variation. However, the updating procedure showed a shift towards higher and less variable values for worm kill but not for any other drug-related parameters. An intriguing finding is that the stability in key biological parameters could be disrupted by a significant reduction in the vector biting rate prevailing in a locality.Temporal invariance of biological parameters in the face of intervention perturbations indicates a robust adaptation of LF transmission to local ecological conditions. The results imply that understanding the mechanisms that underlie locally adapted transmission dynamics will

Subjective Performance Evaluations, Self-esteem, and Ego-threats in Principal-agent Relations

DEFF Research Database (Denmark)

Sebald, Alexander Christopher; Walzl, Markus

find that agents sanction whenever the feedback of principals is below their subjective self-evaluations even if the agents' payoff is independent of the principals' feedback. Based on our experimental analysis we propose a principal-agent model with subjective performance evaluations that accommodates...

A principal components model of soundscape perception.

Science.gov (United States)

Axelsson, Östen; Nilsson, Mats E; Berglund, Birgitta

2010-11-01

There is a need for a model that identifies underlying dimensions of soundscape perception, and which may guide measurement and improvement of soundscape quality. With the purpose to develop such a model, a listening experiment was conducted. One hundred listeners measured 50 excerpts of binaural recordings of urban outdoor soundscapes on 116 attribute scales. The average attribute scale values were subjected to principal components analysis, resulting in three components: Pleasantness, eventfulness, and familiarity, explaining 50, 18 and 6% of the total variance, respectively. The principal-component scores were correlated with physical soundscape properties, including categories of dominant sounds and acoustic variables. Soundscape excerpts dominated by technological sounds were found to be unpleasant, whereas soundscape excerpts dominated by natural sounds were pleasant, and soundscape excerpts dominated by human sounds were eventful. These relationships remained after controlling for the overall soundscape loudness (Zwicker's N(10)), which shows that 'informational' properties are substantial contributors to the perception of soundscape. The proposed principal components model provides a framework for future soundscape research and practice. In particular, it suggests which basic dimensions are necessary to measure, how to measure them by a defined set of attribute scales, and how to promote high-quality soundscapes.

Dimensionality reduction of collective motion by principal manifolds

Science.gov (United States)

Gajamannage, Kelum; Butail, Sachit; Porfiri, Maurizio; Bollt, Erik M.

2015-01-01

While the existence of low-dimensional embedding manifolds has been shown in patterns of collective motion, the current battery of nonlinear dimensionality reduction methods is not amenable to the analysis of such manifolds. This is mainly due to the necessary spectral decomposition step, which limits control over the mapping from the original high-dimensional space to the embedding space. Here, we propose an alternative approach that demands a two-dimensional embedding which topologically summarizes the high-dimensional data. In this sense, our approach is closely related to the construction of one-dimensional principal curves that minimize orthogonal error to data points subject to smoothness constraints. Specifically, we construct a two-dimensional principal manifold directly in the high-dimensional space using cubic smoothing splines, and define the embedding coordinates in terms of geodesic distances. Thus, the mapping from the high-dimensional data to the manifold is defined in terms of local coordinates. Through representative examples, we show that compared to existing nonlinear dimensionality reduction methods, the principal manifold retains the original structure even in noisy and sparse datasets. The principal manifold finding algorithm is applied to configurations obtained from a dynamical system of multiple agents simulating a complex maneuver called predator mobbing, and the resulting two-dimensional embedding is compared with that of a well-established nonlinear dimensionality reduction method.

The Networked Principal: Examining Principals' Social Relationships and Transformational Leadership in School and District Networks

Science.gov (United States)

Moolenaar, Nienke M.; Sleegers, Peter J. C.

2015-01-01

Purpose: While in everyday practice, school leaders are often involved in social relationships with a variety of stakeholders both within and outside their own schools, studies on school leaders' networks often focus either on networks within or outside schools. The purpose of this paper is to investigate the extent to which principals occupy…

Geometry of Quantum Principal Bundles. Pt. 1

International Nuclear Information System (INIS)

Durdevic, M.

1996-01-01

A theory of principal bundles possessing quantum structure groups and classical base manifolds is presented. Structural analysis of such quantum principal bundles is performed. A differential calculus is constructed, combining differential forms on the base manifold with an appropriate differential calculus on the structure quantum group. Relations between the calculus on the group and the calculus on the bundle are investigated. A concept of (pseudo)tensoriality is formulated. The formalism of connections is developed. In particular, operators of horizontal projection, covariant derivative and curvature are constructed and analyzed. Generalizations of the first Structure Equation and of the Bianchi identity are found. Illustrative examples are presented. (orig.)

Principals' Self-Efficacy: Relations with Job Autonomy, Job Satisfaction, and Contextual Constraints

Science.gov (United States)

Federici, Roger A.

2013-01-01

The purpose of the present study was to explore relations between principals' self-efficacy, perceived job autonomy, job satisfaction, and perceived contextual constraints to autonomy. Principal self-efficacy was measured by a multidimensional scale called the Norwegian Principal Self-Efficacy Scale. Job autonomy, job satisfaction, and contextual…

77 FR 62185 - Temporary Rule Regarding Principal Trades With Certain Advisory Clients

Science.gov (United States)

2012-10-12

... 3235-AJ96 Temporary Rule Regarding Principal Trades With Certain Advisory Clients AGENCY: Securities... principal capacity in transactions with certain of their advisory clients. The amendment would extend the... Advisers Act when they act in a principal capacity in transactions with certain of their advisory clients...

75 FR 75650 - Temporary Rule Regarding Principal Trades With Certain Advisory Clients

Science.gov (United States)

2010-12-06

... 3235-AJ96 Temporary Rule Regarding Principal Trades With Certain Advisory Clients AGENCY: Securities... principal capacity in transactions with certain of their advisory clients. The amendment would extend the... Advisers Act when they act in a principal capacity in transactions with certain of their advisory clients...

The Principal and Tort Liability.

Science.gov (United States)

Stern, Ralph D.

The emphasis of this chapter is on the tort liability of principals, especially their commission of unintentional torts or torts resulting from negligent conduct. A tort is defined as a wrongful act, not including a breach of contract or trust, which results in injury to another's person, property, or reputation and for which the injured party is…

Constructing principals' professional identities through life stories: an exploration

Directory of Open Access Journals (Sweden)

Jabulani Mpungose

2010-01-01

Full Text Available Adopting a humanistic perspective to the study of leadership, I discuss and describe how school principals adapt to their new roles, owing to the new education policies and educational restructuring within the South African Department of Education. The Life History approach was used to collect data from six selected school principals in KwaZulu-Natal. On the basis of the analysis of data, I conclude that leaders create their provisional selves and construct their professional identities from their personal and professional knowledge. Provisional selves, in this context, are temporary solutions principals use to close the gap between their current capacities and self-concepts, and the ideas they hold about what attitudes and behaviours are expected in their new roles.

Leadership Styles of Principals and Job Performance of Staff in ...

African Journals Online (AJOL)

Leadership Styles of Principals and Job Performance of Staff in Secondary Schools in Delta State of Nigeria. ... recommended that principals should adopt the democratic leadership style to boost better job performance among staff and in essence enhance administrative effectiveness and students‟ academic performance.

Is mass drug administration against lymphatic filariasis required in urban settings? The experience in Kano, Nigeria.

Science.gov (United States)

Pam, Dung D; de Souza, Dziedzom K; D'Souza, Susan; Opoku, Millicent; Sanda, Safiya; Nazaradden, Ibrahim; Anagbogu, Ifeoma N; Okoronkwo, Chukwu; Davies, Emmanuel; Elhassan, Elisabeth; Molyneux, David H; Bockarie, Moses J; Koudou, Benjamin G

2017-10-01

The Global Programme to Eliminate Lymphatic Filariasis (GPELF), launched in 2000, has the target of eliminating the disease as a public health problem by the year 2020. The strategy adopted is mass drug administration (MDA) to all eligible individuals in endemic communities and the implementation of measures to reduce the morbidity of those suffering from chronic disease. Success has been recorded in many rural endemic communities in which elimination efforts have centered. However, implementation has been challenging in several urban African cities. The large cities of West Africa, exemplified in Nigeria in Kano are challenging for LF elimination program because reaching 65% therapeutic coverage during MDA is difficult. There is therefore a need to define a strategy which could complement MDA. Thus, in Kano State, Nigeria, while LF MDA had reached 33 of the 44 Local Government Areas (LGAs) there remained eleven 'urban' LGAs which had not been covered by MDA. Given the challenges of achieving at least 65% coverage during MDA implementation over several years in order to achieve elimination, it may be challenging to eliminate LF in such settings. In order to plan the LF control activities, this study was undertaken to confirm the LF infection prevalence in the human and mosquito populations in three urban LGAs. The prevalence of circulating filarial antigen (CFA) of Wuchereria bancrofti was assessed by an immuno-chromatography test (ICT) in 981 people in three urban LGAs of Kano state, Nigeria. Mosquitoes were collected over a period of 4 months from May to August 2015 using exit traps, gravid traps and pyrethrum knock-down spray sheet collections (PSC) in different households. A proportion of mosquitoes were analyzed for W. bancrofti, using dissection, loop-mediated isothermal amplification (LAMP) assay and conventional polymerase chain reaction (PCR). The results showed that none of the 981 subjects (constituted of West Africa may not be of significant importance

How Does a Community of Principals Develop Leadership for Technology-Enhanced Science?

Science.gov (United States)

Gerard, Libby F.; Bowyer, Jane B.; Linn, Marcia C.

2010-01-01

Active principal leadership can help sustain and scale science curriculum reform. This study illustrates how principal leadership developed in a professional learning community to support a technology-enhanced science curriculum reform funded by the National Science Foundation. Seven middle school and high school principals in one urban-fringe…

The Gender of Secondary School Principals.

Science.gov (United States)

Bonuso, Carl; Shakeshaft, Charol

1983-01-01

A study was conducted to understand why so few of the secondary school principals in New York State are women. Results suggest two possible causes: either sufficient women candidates do not apply for the positions, or sex discrimination still exists. (KH)

Principal Leadership and Teacher Motivation under High-Stakes Accountability Policies

Science.gov (United States)

Finnigan, Kara S.

2010-01-01

This article examines principal leadership and teacher motivation in schools under accountability sanctions. The conceptual framework is grounded in research on expectancy theory and transformational leadership. The study involves a survey of Chicago teachers and indicates that principal instructional leadership and support for change are…

Principals' Opinions of Organisational Justice in Elementary Schools in Turkey

Science.gov (United States)

Aydin, Inayet; Karaman-Kepenekci, Yasemin

2008-01-01

Purpose--This study aims to present the opinions of public elementary school principals in Turkey about the current organisational justice practices among teachers from the distributive, procedural, interactional, and rectificatory dimensions. Design/methodology/approach--The opinions of 11 public elementary school principals in Ankara about…

Principals' Perceptions of Public Schools' Professional Development Changes during NCLB

Science.gov (United States)

Wieczorek, Douglas

2017-01-01

This study investigated public school principals' reports of professional development implementation at the school level while working in different state- and local-level contexts (state accountability level, geographic locations, socioeconomic status, demographics, and grade levels). I attempted to measure principals' reported changes in levels…

Generalized principal resonance in oscillatory systems of second order; Resonancia principal generalizada en sistemas oscilatorios de segundo orden

Energy Technology Data Exchange (ETDEWEB)

Munoz Aguirre, E. [Universidad Autonoma de Puebla, Oaxaca (Mexico); Alexandrov, V. V. [Benemerita Universidad Autonoma de Puebla, Puebla (Mexico)

2001-02-01

This paper will describe the generalized principal resonance of systems as described by the second order of ordinary differential equations and proved by the Pontriaguin maximal principle to coincide with the lengthened solution of an external problem of the same system. The results are verified in special cases of general resonance and parametric resonance for the Mathieu equation. [Spanish] En el presente articulo se estudia la resonancia principal generalizada para sistemas descritos por ecuaciones diferenciales ordinarias de segundo orden y se demuestra con ayuda del principio del maximo de Pontriaguin, la coincidencia de esta con la solucion prolongada de un problema extremal para el mismo sistema. Ademas se verifican estos resultados en los casos particulares de resonancia general y resonancia parametrica para la ecuacion de Mathieu.

A Matter of Definition: Is There Truly a Shortage of School Principals?

Science.gov (United States)

Roza, Marguerite

Although some districts and areas have experienced difficulty finding good principals, there are far more candidates certified to be principals than there are principal vacancies to fill. This report describes a study based on a written indepth survey of human-resource directors supplemented by formal survey questions to school superintendents and…

A Principal Striving for Effective Instructional Leadership in an Era of Accountability

Science.gov (United States)

Mazzoni, Matthew J.

2017-01-01

The purpose of this case study was to explore a principal's experiences and how they aligned to Hallinger and Murphy's (1985) effective instructional leadership practices in an era of accountability. This study of effective principal leadership is timely and relevant due to the recent implementation of national and state mandates for principals to…

Identifying and Addressing Themes of Job Dissatisfaction for Secondary Principals

Science.gov (United States)

De Jong, David; Grundmeyer, Trent; Yankey, Julie

2017-01-01

Secondary principals serve in important roles that are complex, high-stress, and include demanding job responsibilities. Key stakeholders such as superintendents, school board members, and legislators must understand the challenges facing secondary principals in order to address the current themes of job dissatisfaction. Using new survey data…

Discretion in Student Discipline: Insight into Elementary Principals' Decision Making

Science.gov (United States)

Findlay, Nora M.

2015-01-01

Little research exists that examines the exercise of discretion by principals in their disciplinary decision making. This study sought to understand the application of values by principals as they engage in student disciplinary decision making within legally fixed parameters of their administrative discretion. This qualitative methodology used…

Religious Intolerance: The Case of Principals in Multi-faith Schools ...

African Journals Online (AJOL)

This article reports on a qualitative study framed in a phenomenological research design and aimed at investigating how school principals describe their mediating role when implementing religion-in-education policy at schools. Data were collected by means of narrative interviews. Stories of twelve school principals ...

Effective Principals, Effective Schools: Arriving at Site-Based Decision-Making with Successful Principals and Teacher Participation.

Science.gov (United States)

Charles, Gregory Stewart; Karr-Kidwell, PJ

This paper reviews research on principals' and teachers' roles in site-based decision making (SBDM). Research examining teacher participation in SBDM is reviewed, finding that higher quality teaching behaviors and higher student academic attainment resulted from teacher participation. The review focuses on steps in implementing SBDM, means for…

Creating a New Approach to Principal Leadership: The National Institute of School Leadership has Borrowed from the Leadership Practices of Other Professions to Build an Innovative Program for Principals

Science.gov (United States)

Hughes, Robert C.

2005-01-01

The author describes a principal training program resulting from a study that found disconnects between education leadership programs and what principals need to know and be able to do to guide improved instruction. The National Institute for School Leadership program focuses on practicing principals but also has applications for aspiring…

Integrated risk mapping and landscape characterisation of lymphatic filariasis and loiasis in South West Nigeria

Directory of Open Access Journals (Sweden)

Tara A. Brant

2018-02-01

Full Text Available Nigeria has the heaviest burden of lymphatic filariasis (LF in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis is an impediment due to the risk of severe adverse events (SAEs associated with the drug ivermectin. To better understand factors influencing LF elimination in loiasis areas, this study conducted a cross-sectional survey on the prevalence and co-distribution of the two infections, and the potential demographic, landscape, human movement, and intervention-related risk factors at a micro-level in the South West zone of Nigeria. In total, 870 participants from 10 communities on the fringe of a meso-endemic loiasis area of Osun State were selected. LF prevalence was measured by clinical assessment and using the rapid immunochromatographic test (ICT to detect W. bancrofti antigen. Overall LF prevalence was low with ICT positivity ranging from 0 to 4.7%, with only 1 hydrocoele case identified. Males had significantly higher ICT positivity than females (3.2% vs 0.8%. Participants who did not sleep under a bed net had higher ICT positivity (4.0% than those who did (1.3%. ICT positivity was also higher in communities with less tree coverage/canopy height (2.5–2.8% than more forested areas with greater tree coverage/canopy height (0.9–1.0%. In comparison, loiasis was determined using the rapid assessment procedure for loiasis (RAPLOA, and found in all 10 communities with prevalence ranging from 1.4% to 11.2%. No significant difference was found by participants' age or sex. However, communities with predominately shrub land (10.4% or forested land cover (6.2% had higher prevalence than those with mosaic vegetation/croplands (2.5%. Satellite imagery

Sparse Principal Component Analysis in Medical Shape Modeling

DEFF Research Database (Denmark)

Sjöstrand, Karl; Stegmann, Mikkel Bille; Larsen, Rasmus

2006-01-01

Principal component analysis (PCA) is a widely used tool in medical image analysis for data reduction, model building, and data understanding and exploration. While PCA is a holistic approach where each new variable is a linear combination of all original variables, sparse PCA (SPCA) aims...... analysis in medicine. Results for three different data sets are given in relation to standard PCA and sparse PCA by simple thresholding of sufficiently small loadings. Focus is on a recent algorithm for computing sparse principal components, but a review of other approaches is supplied as well. The SPCA...

Opinions of Primary and Secondary School Principals about Internal and External Motivation

Science.gov (United States)

Erdem, Ali Riza; Cicekdemir, Ibrahim

2016-01-01

Problem Statement: "Motivation" can be defined as the action of directing human behavior in a desirable way. School principals are not only the managers who are the most responsible for the school. The vice principals who are officially charged and help the principals with the school tasks are also called school managers. School managers…

Preparing Novice Principals in Australia and Turkey: How Similar Are Their Needs?

Science.gov (United States)

Wildy, Helen; Clarke, Simon; Styles, Irene; Beycioglu, Kadir

2010-01-01

Part of a 13-nation, cross-cultural study of the extent to which principals perceive their pre-appointment experiences had prepared them for the job, the International Study of Principal Preparation (ISPP), this paper compares the responses of novice principals in Turkey and Western Australia. Using a survey based on data from case studies of…

Investment Success in Public Health: An Analysis of the Cost-Effectiveness and Cost-Benefit of the Global Programme to Eliminate Lymphatic Filariasis

Science.gov (United States)

Bettis, Alison A.; Chu, Brian K.; McFarland, Deborah A.; Hooper, Pamela J.; Mante, Sunny D.; Fitzpatrick, Christopher; Bradley, Mark H.

2017-01-01

Abstract Background. It has been estimated that $154 million per year will be required during 2015–2020 to continue the Global Programme to Eliminate Lymphatic Filariasis (GPELF). In light of this, it is important to understand the program’s current value. Here, we evaluate the cost-effectiveness and cost-benefit of the preventive chemotherapy that was provided under the GPELF between 2000 and 2014. In addition, we also investigate the potential cost-effectiveness of hydrocele surgery. Methods. Our economic evaluation of preventive chemotherapy was based on previously published health and economic impact estimates (between 2000 and 2014). The delivery costs of treatment were estimated using a model developed by the World Health Organization. We also developed a model to investigate the number of disability-adjusted life years (DALYs) averted by a hydrocelectomy and identified the cost threshold under which it would be considered cost-effective. Results. The projected cost-effectiveness and cost-benefit of preventive chemotherapy were very promising, and this was robust over a wide range of costs and assumptions. When the economic value of the donated drugs was not included, the GPELF would be classed as highly cost-effective. We projected that a typical hydrocelectomy would be classed as highly cost-effective if the surgery cost less than $66 and cost-effective if less than $398 (based on the World Bank’s cost-effectiveness thresholds for low income countries). Conclusions. Both the preventive chemotherapy and hydrocele surgeries provided under the GPELF are incredibly cost-effective and offer a very good investment in public health. PMID:27956460

From Redistribution to Recognition: How School Principals Perceive Social Justice

Science.gov (United States)

Wang, Fei

2016-01-01

Where there are people, there is social in/justice. Using Nancy Fraser's framework, this qualitative research examines how school principals perceive social justice in schools. Twenty-one elementary and secondary school principals were interviewed in the Greater Toronto Area. The study provides some empirical evidence on the ways social…

The Relationship of Principal Conflict Management Style and School Climate

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Boucher, Miriam Miley

2013-01-01

Using a mixed-methods design, this study examined conflict management styles of elementary school principals in South Carolina and the relationship of conflict management style and school climate. The Rahim Organizational Conflict Inventory-II, Form B, which identifies five styles of managing conflict, was used to determine principal conflict…

High School Principals as Leaders: Styles and Sources of Power

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Brinia, Vasiliki; Papantoniou, Eva

2016-01-01

Purpose: The purpose of this paper is to present the characteristics of leadership (style adopted, sources of power exercised and factors affecting leadership) of high school principals in Greece. Design/Methodology/Approach: In total, 235 school principals were surveyed using questionnaires. These questionnaires assessed how often they adopted…

Evading Equity: Principal Autonomy under the Bloomberg-Klein Market Regime

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Lewis-Durham, Tiffanie C.

2015-01-01

Using New York City schools as a case study, this study draws on interview data from principals, district consultants and administrators, and principal's union representatives to explore the relationship between market-based reform and colorblindness in educational policy. The study is informed by colorblindness theory, which explores the subtle…

School Principals' Authentic Leadership and Teachers' Psychological Capital: Teachers' Perspectives

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Feng, Feng-I

2016-01-01

This study examined teachers' perceptions of principals' authentic leadership and the relationship of authentic leadership to teachers' psychological capital in Taiwan. A total of 1,429 elementary and secondary school teachers were surveyed. The results showed that teachers perceived their principals' authentic leadership as moderate and that the…

Teacher and Principal Perceptions of How Principal Transformational and Instructional Leadership Behaviors Relate to Student Achievement

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Steele, Gayle

2012-01-01

Because of public concern over the effectiveness of our schools, a new evaluation system was put in place to hold principals and teachers directly accountable for student academic achievement. Part of this evaluation included student performance on state assessments. The purpose of this qualitative study sought to examine how the transformation…

Instructional Leadership Behaviors in Principals Who Attended an Assistant Principals' Academy: Self-Reports and Teacher Perceptions

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Gurley, D. Keith; Anast-May, Linda; O'Neal, Marcia; Lee, H. T.; Shores, Melanie

2015-01-01

Focus on the development of instructional leadership skills for school principals in the U.S. continues to be at the forefront of educational research and reform in response to the increased call for accountability. In this article we review relevant literature regarding instructional leadership from a historical perspective, then present a…

Principals' instructional management skills and middle school science teacher job satisfaction

Science.gov (United States)

Gibbs-Harper, Nzinga A.

The purpose of this research study was to determine if a relationship exists between teachers' perceptions of principals' instructional leadership behaviors and middle school teacher job satisfaction. Additionally, this study sought to assess whether principal's instructional leadership skills were predictors of middle school teachers' satisfaction with work itself. This study drew from 13 middle schools in an urban Mississippi school district. Participants included teachers who taught science. Each teacher was given the Principal Instructional Management Rating Scale (PIMRS; Hallinger, 2011) and the Teacher Job Satisfaction Questionnaire (TJSQ; Lester, 1987) to answer the research questions. The study was guided by two research questions: (a) Is there a relationship between the independent variables Defining the School's Mission, Managing the Instructional Program, and Developing the School Learning Climate Program and the dependent variable Work Itself?; (b) Are Defining the School's Mission, Managing the Instructional Program, and Developing the School Learning Climate Program predictors of Work Itself? The Pearson's correlation and multiple regression analysis were utilized to examine the relationship between the three dimensions of principals' instructional leadership and teacher satisfaction with work itself. The data revealed that there was a strong, positive correlation between all three dimensions of principals' instructional leadership and teacher satisfaction with work itself. However, the multiple regression analysis determined that teachers' perceptions of principals' instructional management skills is a slight predictor of Defining the School's Mission only.

Perceptions of School Principals on Participation in Professional Learning Communities as Job-Embedded Learning

Science.gov (United States)

Gaudioso, Jennifer A.

2017-01-01

Perceptions of School Principals on Participation in Professional Learning Communities as Job-Embedded Learning Jennifer Gaudioso Principal Professional Learning Communities (PPLCs) have emerged as a vehicle for professional development of principals, but there is little research on how principals experience PPLCs or how districts can support…

Interpretable functional principal component analysis.

Science.gov (United States)

Lin, Zhenhua; Wang, Liangliang; Cao, Jiguo

2016-09-01

Functional principal component analysis (FPCA) is a popular approach to explore major sources of variation in a sample of random curves. These major sources of variation are represented by functional principal components (FPCs). The intervals where the values of FPCs are significant are interpreted as where sample curves have major variations. However, these intervals are often hard for naïve users to identify, because of the vague definition of "significant values". In this article, we develop a novel penalty-based method to derive FPCs that are only nonzero precisely in the intervals where the values of FPCs are significant, whence the derived FPCs possess better interpretability than the FPCs derived from existing methods. To compute the proposed FPCs, we devise an efficient algorithm based on projection deflation techniques. We show that the proposed interpretable FPCs are strongly consistent and asymptotically normal under mild conditions. Simulation studies confirm that with a competitive performance in explaining variations of sample curves, the proposed FPCs are more interpretable than the traditional counterparts. This advantage is demonstrated by analyzing two real datasets, namely, electroencephalography data and Canadian weather data. © 2015, The International Biometric Society.

A Principal's Guide to Children's Allergies.

Science.gov (United States)

Munoz-Furlong, Anne

1999-01-01

Discusses several common children's allergies, including allergic rhinitis, asthma, atopic dermatitis, food allergies, and anaphylactic shock. Principals should become familiar with various medications and should work with children's parents and physicians to determine how to manage their allergies at school. Allergen avoidance is the best…

Principal Components as a Data Reduction and Noise Reduction Technique

Science.gov (United States)

Imhoff, M. L.; Campbell, W. J.

1982-01-01

The potential of principal components as a pipeline data reduction technique for thematic mapper data was assessed and principal components analysis and its transformation as a noise reduction technique was examined. Two primary factors were considered: (1) how might data reduction and noise reduction using the principal components transformation affect the extraction of accurate spectral classifications; and (2) what are the real savings in terms of computer processing and storage costs of using reduced data over the full 7-band TM complement. An area in central Pennsylvania was chosen for a study area. The image data for the project were collected using the Earth Resources Laboratory's thematic mapper simulator (TMS) instrument.

Critical Factors Explaining the Leadership Performance of High-Performing Principals

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Hutton, Disraeli M.

2018-01-01

The study explored critical factors that explain leadership performance of high-performing principals and examined the relationship between these factors based on the ratings of school constituents in the public school system. The principal component analysis with the use of Varimax Rotation revealed that four components explain 51.1% of the…

School Principals' Job Satisfaction: The Effects of Work Intensification

Science.gov (United States)

Wang, Fei; Pollock, Katina; Hauseman, Cameron

2018-01-01

This study examines principals' job satisfaction in relation to their work intensification. Frederick Herzberg's two-factor theory was used to shed light on how motivating and maintenance factors affect principals' job satisfaction. Logistic multiple regressions were used in the analysis of survey data that were collected from 2,701 elementary and…

Measuring School Principals' Support for ICT Integration in Palermo, Italy

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Polizzi, Gabriella

2011-01-01

School principals play an important role in managing media and technology integration into school teaching since they can foster the use of information communication technologies (ICT) at a strategic level, even supporting the introduction of media literacy education activities into teaching. Starting from a review on the role of principals'…

Factors influencing drug uptake during mass drug administration for control of lymphatic filariasis in rural and urban Tanzania.

Directory of Open Access Journals (Sweden)

William J Kisoka

Full Text Available BACKGROUND: In most countries of Sub-Saharan Africa, control of lymphatic filariasis (LF is based on annual mass drug administration (MDA with a combination of ivermectin and albendazole. Treatment coverages are however often suboptimal for programmes to reach the goal of transmission interruption within reasonable time. The present study aimed to identify predictors and barriers to individual drug uptake during MDA implementation by the National LF Elimination Programme in Tanzania. METHODS: A questionnaire based cross sectional household survey was carried out in two rural and two urban districts in Lindi and Morogoro regions shortly after the 2011 MDA. 3279 adults (≥15 years were interviewed about personal characteristics, socio-economic status, MDA drug uptake among themselves and their children, reasons for taking/not taking drugs, and participation in previous MDA activities for LF control. FINDINGS: The overall drug uptake rate was 55.1% (range of 44.5-75.6% between districts. There was no overall major difference between children (54.8% and adults (55.2% or between females (54.9% and males (55.8%, but the role of these and other predictors varied to some extent between study sites. Major overall predictors of drug uptake among the interviewed adults were increasing age and history of previous drug uptake. Being absent from home during drug distribution was the main reason for not taking the drugs (50.2% followed by clinical contraindications to treatment (10.8%, missing household visits of drug distributors (10.6%, and households not being informed about the distribution (9.0%. CONCLUSION: Drug uptake relied more on easily modifiable provider-related factors than on individual perceptions and practices in the target population. Limited investments in appropriate timing, dissemination of accurate timing information to recipients and motivation of drug distributors to visit all households (repeatedly when residents are absent are likely

Informing principal policy reforms in South Africa through data-based evidence

OpenAIRE

Gabrielle Wills

2015-01-01

In the past decade there has been a notable shift in South African education policy that raises the value of school leadership as a lever for learning improvements. Despite a growing discourse on school leadership, there has been a lack of empirical based evidence on principals to inform, validate or debate the efficacy of proposed policies in raising the calibre of school principals. Drawing on findings from a larger study to understand the labour market for school principals in South Africa...

Implementing Comprehensive School Health in Alberta, Canada: the principal's role.

Science.gov (United States)

Roberts, Erica; McLeod, Nicole; Montemurro, Genevieve; Veugelers, Paul J; Gleddie, Doug; Storey, Kate E

2016-12-01

Comprehensive School Health (CSH) is an internationally recognized framework that moves beyond the individual to holistically address school health, leading to the development of health-enhancing behaviors while also improving educational outcomes. Previous research has suggested that principal support for CSH implementation is essential, but this role has yet to be explored. Therefore, the purpose of this research was to examine the role of the principal in the implementation of a CSH project aimed at creating a healthy school culture. This research was guided by the grounded ethnography method. Semi-structured interviews were conducted with APPLE School principals (n = 29) to qualitatively explore their role in creating a healthy school culture. A model consisting of five major themes emerged, suggesting that the principal played a fluid role throughout the CSH implementation process. Principals (i) primed the cultural change; (ii) communicated the project's importance to others; (iii) negotiated concerns and collaboratively planned; (iv) held others accountable to the change, while enabling them to take ownership and (v) played an underlying supportive role, providing positive recognition and establishing ongoing commitment. This research provides recommendations to help establish effective leadership practices in schools, conducive to creating a healthy school culture. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Spatial control of groundwater contamination, using principal

Indian Academy of Sciences (India)

Spatial control of groundwater contamination, using principal component analysis ... anthropogenic (agricultural activities and domestic wastewaters), and marine ... The PC scores reflect the change of groundwater quality of geogenic origin ...

A Review of Singapore Principals' Leadership Qualities, Styles, and Roles

Science.gov (United States)

Ng, David Foo Seong; Nguyen, Dong Thanh; Wong, Benjamin Koon Siak; Choy, William Kim Weng

2015-01-01

Purpose: The purpose of this paper is to present a review of empirical studies on principal leadership in Singapore. It seeks to provide a general picture of Singapore principals' leadership qualities, styles, and roles. Design/methodology/approach: This is a systematic review of empirical studies, using a "bounded" approach with a focus…

Are Teacher and Principal Candidates Prepared to Address Student Cyberbullying?

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Styron, Ronald A., Jr.; Bonner, Jessica L.; Styron, Jennifer L.; Bridgeforth, James; Martin, Cecelia

2016-01-01

The purpose of this study was to examine the preparation of teacher and principal candidates to address problems created in K-12 settings as a result of cyberbullying. Participants included teacher and principal preparation students. Findings indicated that respondents were familiar with the most common forms of cyberbullying and its impact on…

Investing in Leadership: The District's Role in Managing Principal Turnover

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Mascall, Blair; Leithwood, Kenneth

2010-01-01

This article presents the results of research into the impact of principal turnover on schools, and the ability of schools to mitigate the negative effects of frequent turnover by distributing leadership in the schools. The findings from this qualitative and quantitative analysis show that rapid principal turnover does indeed have a negative…

The Relationship between Principals' Transformational Leadership Behaviors and School Culture

Science.gov (United States)

Bolton, David A.

2011-01-01

This quantitative study looks at the relationship between a principals' transformational leadership behaviors and the culture of their school. The goal of the study is to determine if transformational leadership qualities have a positive impact on the culture present in a school. Congruency between the views of a principal and their staff will…

Assistant/Deputy Principals: What Are Their Perceptions of Their Role?

Science.gov (United States)

Shore, Kevin; Walshaw, Margaret

2018-01-01

The roles and aspirations of Assistant/Deputy Principals (AP/DPs) have received attention for a number of decades. In contrast to much of the reported research that either highlights the administrative and management tasks or foregrounds principal succession, we explore levels of satisfaction that play into DP/APs' interpretations of the realities…

PCA: Principal Component Analysis for spectra modeling

Science.gov (United States)

Hurley, Peter D.; Oliver, Seb; Farrah, Duncan; Wang, Lingyu; Efstathiou, Andreas

2012-07-01

The mid-infrared spectra of ultraluminous infrared galaxies (ULIRGs) contain a variety of spectral features that can be used as diagnostics to characterize the spectra. However, such diagnostics are biased by our prior prejudices on the origin of the features. Moreover, by using only part of the spectrum they do not utilize the full information content of the spectra. Blind statistical techniques such as principal component analysis (PCA) consider the whole spectrum, find correlated features and separate them out into distinct components. This code, written in IDL, classifies principal components of IRS spectra to define a new classification scheme using 5D Gaussian mixtures modelling. The five PCs and average spectra for the four classifications to classify objects are made available with the code.

Summer Principals'/Directors' Orientation Training Module.

Science.gov (United States)

Mata, Robert L.; Garcia, Richard L.

Intended to provide current or potential project principals/directors with the basic knowledge, skills, abilities, and sensitivities needed to manage a summer migrant school project in the local educational setting, this module provides instruction in the project management areas of planning, preparation, control, and termination. The module…