Sample records for primary design consideration

  1. DOE handbook: Design considerations



    The Design Considerations Handbook includes information and suggestions for the design of systems typical to nuclear facilities, information specific to various types of special facilities, and information useful to various design disciplines. The handbook is presented in two parts. Part 1, which addresses design considerations, includes two sections. The first addresses the design of systems typically used in nuclear facilities to control radiation or radioactive materials. Specifically, this part addresses the design of confinement systems and radiation protection and effluent monitoring systems. The second section of Part 1 addresses the design of special facilities (i.e., specific types of nonreactor nuclear facilities). The specific design considerations provided in this section were developed from review of DOE 6430.1A and are supplemented with specific suggestions and considerations from designers with experience designing and operating such facilities. Part 2 of the Design Considerations Handbook describes good practices and design principles that should be considered in specific design disciplines, such as mechanical systems and electrical systems. These good practices are based on specific experiences in the design of nuclear facilities by design engineers with related experience. This part of the Design Considerations Handbook contains five sections, each of which applies to a particular engineering discipline.

  2. Primary Considerations for Primary TEFL in China

    Yvonne Griffiths


    This article will focus on five key areas relating to Primary TEFL in China. Firstly, the real TEFL context in Chinese primary schools will be discussed in terms of its special characteristics. Secondly, the current methodological approach will be examined from both a theoretical perspective, focusing on government (MOE) policy for primary TEFL, and a practical perspective, based on personal observations of classroom practice. The third section of the article will highlight some perceived shortcomings of current practice, while the fourth will outline the actual needs of primary learners in the Chinese educational system. Finally, the question of how teachers can meet these needs will be examined in relation to: methodological integration;integration of skills and sub-skills teaching/learning; and the exploitation of materials and activities to provide learners with three different types of language input and output opportunities (extensive, intensive and analysed: Swan, 2006).

  3. User interface design considerations

    Andersen, Simon Engedal; Jakobsen, Arne; Rasmussen, Bjarne D.


    When designing a user interface for a simulation model there are several important issues to consider: Who is the target user group, and which a priori information can be expected. What questions do the users want answers to and what questions are answered using a specific model?When developing...... the user interface of EESCoolTools these issues led to a series of simulation tools each with a specific purpose and a carefully selected set of input and output variables. To allow a more wide range of questions to be answered by the same model, the user can change between different sets of input...... and output variables. This feature requires special attention when designing the user interface and a special approach for controlling the user selection of input and output variables are developed. To obtain a consistent system description the different input variables are grouped corresponding...

  4. One Shot to an Asteroid- MASCOT and the Design of an Exclusively Primary Battery Powered Small Spacecraft in Hardware Design Examples and Operations Considerations

    Grundmann, Jan Thimo; Biele, Jens; Findlay, Ross; Fredon, Stephane; Ho, Tra-Mi; Krause, Christian; Ulamec, Stephan; Ziach, Christian


    The Mobile Asteroid Surface Scout, MASCOT, is a small, 11 kg mobile asteroid lander for the Japanese space probe HAYABUSA-2. It carries four science instruments, a redundant command chain, and a mobility mechanism. On-asteroid power is provided by a Li-SOCl2 primary battery, interplanetary cruise power and thermal control by umbilical connection. The power subsystem manages the activation of MASCOT. It uses a mixed configuration of isolated and non-isolated, redundant and non-redundant supply lines to stay within tight system constraints. Due to the short project timeline, extensive and early testing of integrated hardware was used, often combining off-the-shelf available designs and units of different maturity levels. An overview, progress and lessons learned are shown.

  5. Lunar Navigation Architecture Design Considerations

    D'Souza, Christopher; Getchius, Joel; Holt, Greg; Moreau, Michael


    The NASA Constellation Program is aiming to establish a long-term presence on the lunar surface. The Constellation elements (Orion, Altair, Earth Departure Stage, and Ares launch vehicles) will require a lunar navigation architecture for navigation state updates during lunar-class missions. Orion in particular has baselined earth-based ground direct tracking as the primary source for much of its absolute navigation needs. However, due to the uncertainty in the lunar navigation architecture, the Orion program has had to make certain assumptions on the capabilities of such architectures in order to adequately scale the vehicle design trade space. The following paper outlines lunar navigation requirements, the Orion program assumptions, and the impacts of these assumptions to the lunar navigation architecture design. The selection of potential sites was based upon geometric baselines, logistical feasibility, redundancy, and abort support capability. Simulated navigation covariances mapped to entry interface flightpath- angle uncertainties were used to evaluate knowledge errors. A minimum ground station architecture was identified consisting of Goldstone, Madrid, Canberra, Santiago, Hartebeeshoek, Dongora, Hawaii, Guam, and Ascension Island (or the geometric equivalent).

  6. Future space suit design considerations.


    Future space travel to the moon and Mars will present new challenges in space suit design. This paper examines the impact that working on the surface environment of the moon and Mars will have on the requirements of space suits. In particular, habitat pressures will impact suit weight and design. Potential structural materials are explored, as are the difficulties in designing a suit to withstand the severe dust conditions expected.

  7. Rook Jumping Maze Design Considerations

    Neller, Todd W.; Fisher, Adrian; Choga, Munyaradzi T.; Lalvani, Samir M.; McCarty, Kyle D.

    We define the Rook Jumping Maze, provide historical perspective, and describe a generation method for such mazes. When applying stochastic local search algorithms to maze design, most creative effort concerns the definition of an objective function that rates maze quality. We define and discuss several maze features to consider in such a function definition. Finally, we share our preferred design choices, make design process observations, and note the applicability of these techniques to variations of the Rook Jumping Maze.

  8. Smile design--specific considerations.

    Morley, J


    Smile design is a new discipline that has come to the forefront with the recent popularity of cosmetic dentistry techniques. This article explores some of the principles used in smile design that can enhance the esthetics of any anterior restorative procedure.

  9. Mechanical considerations and design skills.

    Alvis, Robert L.


    The purpose of the report is to provide experienced-based insights into design processes that will benefit designers beginning their employment at Sandia National Laboratories or those assuming new design responsibilities. The main purpose of this document is to provide engineers with the practical aspects of system design. The material discussed here may not be new to some readers, but some of it was to me. Transforming an idea to a design to solve a problem is a skill, and skills are similar to history lessons. We gain these skills from experience, and many of us have not been fortunate enough to grow in an environment that provided the skills that we now need. I was fortunate to grow up on a farm where we had to learn how to maintain and operate several different kinds of engines and machines. If you are like me, my formal experience is partially based upon the two universities from which I graduated, where few practical applications of the technologies were taught. What was taught was mainly theoretical, and few instructors had practical experience to offer the students. I understand this, as students have their hands full just to learn the theoretical. The practical part was mainly left up to 'on the job experience'. However, I believe it is better to learn the practical applications early and apply them quickly 'on the job'. System design engineers need to know several technical things, both in and out of their field of expertise. An engineer is not expected to know everything, but he should know when to ask an expert for assistance. This 'expert' can be in any field, whether it is in analyses, drafting, machining, material properties, testing, etc. The best expert is a person who has practical experience in the area of needed information, and consulting with that individual can be the best and quickest way for one to learn. If the information provided here can improve your design skills and save one design from having a problem

  10. Design considerations in a clinical trial of a cognitive behavioural intervention for the management of low back pain in primary care: Back Skills Training Trial

    Griffiths Frances E


    Full Text Available Abstract Background Low back pain (LBP is a major public health problem. Risk factors for the development and persistence of LBP include physical and psychological factors. However, most research activity has focused on physical solutions including manipulation, exercise training and activity promotion. Methods/Design This randomised controlled trial will establish the clinical and cost-effectiveness of a group programme, based on cognitive behavioural principles, for the management of sub-acute and chronic LBP in primary care. Our primary outcomes are disease specific measures of pain and function. Secondary outcomes include back beliefs, generic health related quality of life and resource use. All outcomes are measured over 12 months. Participants randomised to the intervention arm are invited to attend up to six weekly sessions each of 90 minutes; each group has 6–8 participants. A parallel qualitative study will aid the evaluation of the intervention. Discussion In this paper we describe the rationale and design of a randomised evaluation of a group based cognitive behavioural intervention for low back pain.

  11. CSM RCS Design Considerations and Failure Modes

    Interbartolo, Michael


    Objectives include: a) Define major Command and Service Module (CSM) design considerations; b) List Command Module (CM) RCS failures and lessons learned; and c) List Service Module (SM) RCS failures and lessons learned.

  12. Human Factors Considerations in System Design

    Mitchell, C. M. (Editor); Vanbalen, P. M. (Editor); Moe, K. L. (Editor)


    Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined. The following topics are discussed: human factors aspects of control room design; design of interactive systems; human computer dialogue, interaction tasks and techniques; guidelines on ergonomic aspects of control rooms and highly automated environments; system engineering for control by humans; conceptual models of information processing; information display and interaction in real time environments.

  13. Implantable intraocular pressure monitoring systems: Design considerations

    Arsalan, Muhammad


    Design considerations and limitations of implantable Intraocular Pressure Monitoring (IOPM) systems are presented in this paper. Detailed comparison with the state of the art is performed to highlight the benefits and challenges of the proposed design. The system-on-chip, presented here, is battery free and harvests energy from incoming RF signals. This low-cost design, in standard CMOS process, does not require any external components or bond wires to function. This paper provides useful insights to the designers of implantable wireless sensors in terms of design choices and associated tradeoffs. © 2013 IEEE.

  14. Design considerations for a gas microcontroller

    Ritter, D. A.


    Some of the design problems that are now being addressed in consideration of a microcontroller for the upcoming GAS payload are discussed. Microcontrollers will be used to run the experiments and to collect and store the data from those experiments. Some of the requirements for a microcontroller are to be small, lightweight, have low power consumption, and high reliability. Some of the solutions that were developed to meet these design requirements are discussed. At present, the experiment is still in the design stage and the final design may change from what is presented here. The search for new integrated circuits which will do all that is needed all in one package continues.

  15. Visual Metadiscourse: Designing the Considerate Text.

    Kumpf, Eric P.


    Considers how visual metadiscourse provides design criteria for authors when considering the needs and expectations of readers. Notes the author's discussions of textual metadiscourse in technical writing classes since 1995. Notes an improvement in the cohesion and considerateness of student writing after rethinking their role as writers and the…

  16. Design considerations for Mars photovoltaic power systems

    Landis, Geoffrey A.; Appelbaum, Joseph


    Considerations for operation of a photovoltaic power system on Mars are discussed with reference to Viking Lander data. The average solar insolation at Mars is 590 W/sq m, which is reduced yet further by atmospheric dust. Of major concern are dust storms, which have been observed to occur on local as well as on global scales, and their effect on solar array output. While atmospheric opacity may rise to values ranging from 3 to 9, depending on storm severity, there is still an appreciable large diffuse illumination, even at high opacities, so that photovoltaic operation is still possible. If the power system is to continue to generate power even on high-optical-opacity (i.e., dusty atmosphere) days, it is important that the photovoltaic system be designed to collect diffuse irradiance as well as direct. Energy storage will be required for operation during the night. Temperature and wind provide additional considerations for array design.

  17. Design considerations for piezoelectric polymer ultrasound transducers.

    Brown, L F


    Much work has been published on the design of ultrasound transducers using piezoelectric ceramics, but a great deal of this work does not apply when using the piezoelectric polymers because of their unique electrical and mechanical properties. The purpose of this paper is to review and present new insight into seven important considerations for the design of active piezoelectric polymer ultrasound transducers: piezoelectric polymer materials selection, transducer construction and packaging requirements, materials characterization and modeling, film thickness and active area design, electroding selection, backing material design, and front protection/matching layer design. Besides reviewing these design considerations, this paper also presents new insight into the design of active piezoelectric polymer ultrasonic transducers. The design and fabrication of an immersible ultrasonic transducer, which has no adhesive layer between the active element and backing layer, is included. The transducer features direct deposition of poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] copolymer onto an insulated aluminum backing substrate. Pulse-echo tests indicated a minimum insertion loss of 37 dB and -6 dB bandwidth of 9.8 to 22 MHz (71%). The use of polymer wear-protection/quarter-wave matching layers is also discussed. Test results on a P(VDF-TrFE) transducer showed that a Mylar/sup TM/ front layer provided a slight increase in pulse-echo amplitude of 15% (or 1.2 dB) and an increase in -6 dB pulse-echo fractional bandwidth from 86 to 95%. Theoretical derivations are reported for optimizing the active area of the piezoelectric polymer element for maximum power transfer at resonance. These derivations are extended to the special case for a low profile (i.e., thin) shielded transducer. A method for modeling the non-linear loading effects of a commercial pulser-receiver is also included.

  18. Design considerations for a ceramic fabric radiator

    Pauley, K.A.; Webb, B.J. (Pacific Northwest Lab., Richland, WA (USA)); Klein, A.C. (Oregon State Univ., Corvallis, OR (USA). Dept. of Nuclear Engineering)


    The design of an Advanced Ceramic Fabric (ACF) thermal management device for use in both interplanetary and near-earth space must consider several important aspects of the environment. First, the radiation field at various locations is dominated by a proton component which deposits its energy on the surface of the device. Second, the ACF materials, as well as pressure liner materials, must also be compatible with the working fluids selected for the system. Third, the fluid dynamics and heat transfer characteristics of this device should be adequately characterized. With the proper consideration of materials and operating conditions, the Bubble Membrane Radiator (BMR) may be utilized for several advanced space missions. 17 refs.

  19. Practical design considerations for photovoltaic power station

    Swanson, T. D.

    Aspects of photovoltaic (PV) technology are discussed along with generic PV design considerations, taking into account the resource sunlight, PV modules and their reliability, questions of PV system design, the support structure subsystem, and a power conditioning unit subsystem. A description is presented of two recent projects which demonstrate the translation of an idea into actual working PV systems. A privately financed project in Denton, Maryland, went on line in early December, 1982, and began providing power to the local utility grid. It represents the first intermediate size, grid-connected, privately financed power station in the U.S. Based on firm quotes, the actual cost of this system is about $13/W peak. The other project, called the PV Breeder, is an energy independent facility which utilizes solar power to make new solar cells. It is also the first large industrial structure completely powered by the sun.

  20. Design considerations for tropical forest inventories

    Ronald Edward McRoberts


    Full Text Available Forests contribute substantially to maintaining the global greenhouse gas balance, primarily because among the five economic sectors identified by the United Nations Framework Convention on Climate Change, only the forestry sector has the potential to remove greenhouse gas emissions from the atmosphere. In this context, development of national forest carbon accounting systems, particularly in countries with tropical forests, has emerged as an international priority. Because these systems are often developed as components of or in parallel with national forest inventories, a brief review of statistical issues related to the development of forest ground sampling designs is provided. This overview addresses not only the primary issues of plot configurations and sampling designs, but also to a lesser extent the emerging roles of remote sensing and uncertainty assessment. Basic inventory principles are illustrated for two case studies, the national forest inventory of Brazil with special emphasis on the state of Santa Catarina, and an inventory for Tanzania.

  1. LBB considerations for a new plant design

    Swamy, S.A.; Mandava, P.R.; Bhowmick, D.C.; Prager, D.E. [Westinghouse Electric Corp., Pittsburgh, PA (United States)


    The leak-before-break (LBB) methodology is accepted as a technically justifiable approach for eliminating postulation of Double-Ended Guillotine Breaks (DEGB) in high energy piping systems. This is the result of extensive research, development, and rigorous evaluations by the NRC and the commercial nuclear power industry since the early 1970s. The DEGB postulation is responsible for the many hundreds of pipe whip restraints and jet shields found in commercial nuclear plants. These restraints and jet shields not only cost many millions of dollars, but also cause plant congestion leading to reduced reliability in inservice inspection and increased man-rem exposure. While use of leak-before-break technology saved hundreds of millions of dollars in backfit costs to many operating Westinghouse plants, value-impacts resulting from the application of this technology for future plants are greater on a per plant basis. These benefits will be highlighted in this paper. The LBB technology has been applied extensively to high energy piping systems in operating plants. However, there are differences between the application of LBB technology to an operating plant and to a new plant design. In this paper an approach is proposed which is suitable for application of LBB to a new plant design such as the Westinghouse AP600. The approach is based on generating Bounding Analyses Curves (BAC) for the candidate piping systems. The general methodology and criteria used for developing the BACs are based on modified GDC-4 and Standard Review Plan (SRP) 3.6.3. The BAC allows advance evaluation of the piping system from the LBB standpoint thereby assuring LBB conformance for the piping system. The piping designer can use the results of the BACs to determine acceptability of design loads and make modifications (in terms of piping layout and support configurations) as necessary at the design stage to assure LBB for the, piping systems under consideration.

  2. Design consideration for magnetically suspended flywheel systems

    Anand, D.; Kirk, J. A.; Frommer, D. A.


    Consideration is given to the design, fabrication, and testing of a magnetically suspended flywheel system for energy storage applications in space. The device is the prototype of a system combining passive suspension of the flywheel plate by samarium cobalt magnets and active control in the radial direction using eight separate magnetic coils. The bearing assembly was machined from a nickel-iron alloy, and the machine parts are all hydrogen annealed. Slots in the magnetic plate allow four independent quadrants for control. The motor/generator component of the system is a brushless dc-permanent magnetic/ironless engine using electronic communication. The system has been tested at over 2500 rpm with satisfactory results. The system characteristics of the flywheel for application in low earth orbit (LEO) are given in a table.

  3. Design considerations for miniaturized optical neural probes

    Rudmann, Linda; Ordonez, Juan S.; Stieglitz, Thomas


    Neural probes are designed to selectively record from or stimulate nerve cells. In optogenetics it is desirable to build miniaturized and long-term stable optical neural probes, in which the light sources can be directly and chronically implanted into the animals to allow free movement and behavior. Because of the size and the beam shape of the available light sources, it is difficult to target single cells as well as spatially localized networks. We therefore investigated design considerations for packages, which encapsulate the light source hermetically and have integrated hemispherical lens structures that enable to focus the light onto the desired region, by optical simulations. Integration of a biconvex lens into the package lid (diameter = 300 μm, material: silicon carbide) increased the averaged absolute irradiance ηA by 298 % compared to a system without a lens and had a spot size of around 120 μm. Solely integrating a plano-convex lens (same diameter and material) results in an ηA of up to 227 %.

  4. Design Considerations For Night Vision Goggles

    Glasheen, W. M.; Reiss, R. S.


    Baird Corporation of Bedford, Massachusetts, has designed and developed two similar night vision goggles. These goggles are binocular viewing to the wearer's eyes, but use a single objective lens and a single image intensifier tube. Binocular viewing is achieved by dividing a single image and sharing it between the'viewer's eyes. The goggles are self-sufficient, independent instruments which can be simply and easily interfaced with a face mask that the viewer wears. This paper covers the main design considerations that are associated with achieving the goals of these goggle configurations and their performance. Baird's first goggle design is designated the GP/NVG; the second is designated the AN/PVS-7. The GP/NVG night vision goggle is a high-performance, single intensifier tube, passive night vision device that provides the user with a 40-degree field of view at unity magnification. The fixed aperture, f/1.0 objective lens collects the available light and images it on the fiber optic faceplate of the second generation image intensifier tube. The image intensifier tube converts the real image at the fiber optic faceplate into electrons across the image, amplifies them, and then reconverts the electrons into a real, visible image at the fiber optic output of the tube. This image is then collimated to appear as if it is coming from infinity, split in two, and reimaged by the relay lenses. The eyelenses provide a magnified image to the user. The user can adjust each eyelens to clearly view the output faceplate of the image intensifier tube. This adjustment is made only once for each user. The objective focus can be manually set for distances from 25 centimeters to infinity. The general configuration of this night vision goggle is similar to that of a pair of single objective binocular field glasses. It is extremely lightweight (with most of the main construction molded from plastic) and compact for easy handling. All adjustments and on/off switching have been "human

  5. Educational Design & ECOP: Considerations and propositions

    McKenney, Susan


    This presentation addresses foundational ideas about educational design, specifically: About design • What is educational design (research)? • What supports curriculum design? About designers • What are common designer struggles? • What can we learn from expert designers? • What are competencies of

  6. Considerations for the design of Ada reusable packages

    Nise, Norman S.; Giffin, Chuck


    Two important considerations that precede the design of Ada reusable packages (commonality and programming standards) are discuessed. First, the importance of designing packages to yield widespread commonality is expressed. A means of measuring the degree of applicability of packages both within and across applications areas is presented. Design consideration that will improve commonality are also discussed. Second, considerations for the development of programming standards are set forth. These considerations will lead to standards that will improve the reusability of Ada packages.

  7. Empirical Design Considerations for Industrial Centrifugal Compressors

    Cheng Xu


    Full Text Available Computational Fluid Dynamics (CFD has been extensively used in centrifugal compressor design. CFD provides further optimisation opportunities for the compressor design rather than designing the centrifugal compressor. The experience-based design process still plays an important role for new compressor developments. The wide variety of design subjects represents a very complex design world for centrifugal compressor designers. Therefore, some basic information for centrifugal design is still very important. The impeller is the key part of the centrifugal stage. Designing a highly efficiency impeller with a wide operation range can ensure overall stage design success. This paper provides some empirical information for designing industrial centrifugal compressors with a focus on the impeller. A ported shroud compressor basic design guideline is also discussed for improving the compressor range.

  8. Networked Learning: Design Considerations for Online Instructors

    Czerkawski, Betul C.


    The considerable increase in web-based knowledge networks in the past two decades is strongly influencing learning environments. Learning entails information retrieval, use, communication, and production, and is strongly enriched by socially mediated discussions, debates, and collaborative activities. It is becoming critical for educators to…

  9. Mechatronic Design - Still a Considerable Challenge

    Torry-Smith, Jonas; Qamar, Ahsan; Achiche, Sofiane


    Development of mechatronic products is traditionally carried out by several design experts from different design domains. Performing development of mechatronic products is thus greatly challenging. In order to tackle this, the critical challenges in mechatronics have to be well understood and wel...

  10. Instructional design considerations promoting engineering design self-efficacy

    Jackson, Andrew M.

    Engineering design activities are frequently included in technology and engineering classrooms. These activities provide an open-ended context for practicing critical thinking, problem solving, creativity, and innovation---collectively part of the 21st Century Skills which are increasingly needed for success in the workplace. Self-efficacy is a perceptual belief that impacts learning and behavior. It has been shown to directly impact each of these 21st Century Skills but its relation to engineering design is only recently being studied. The purpose of this study was to examine how instructional considerations made when implementing engineering design activities might affect student self-efficacy outcomes in a middle school engineering classroom. Student responses to two self-efficacy inventories related to design, the Engineering Design Self-Efficacy Instrument and Creative Thinking Self-Efficacy Inventory, were collected before and after participation in an engineering design curriculum. Students were also answered questions on specific factors of their experience during the curriculum which teachers may exhibit control over: teamwork and feedback. Results were analyzed using Pearson's correlation coefficients, paired and independent t-tests, and structural equation modeling to better understand patterns for self-efficacy beliefs in students. Results suggested that design self-efficacy and creative thinking self-efficacy are significantly correlated, r(1541) = .783, p showed that students perceive team inclusion and feedback as significant contributors to their self-efficacy beliefs, while team diversity was not related to self-efficacy. Separate models for each predictor demonstrated good fit. Recommendations are made based on the corresponding nature of engineering design self-efficacy and creative thinking self-efficacy: strategies encouraging self-efficacy in these domains may be transferrable. Instructors are made aware of the significant impact of classroom

  11. Design considerations for CELT adaptive optics

    Dekany, Richard G.; Nelson, Jerry E.; Bauman, Brian J.


    California Institute of Technology and University of California have begun conceptual design studies for a new telescope for astronomical research at visible and infrared wavelengths. The California Extremely Large Telescope (CELT) is currently envisioned as a filled-aperture, steerable, segmented telescope of approximately 30 m diameter. The key to satisfying many of the science goals of this observatory is the availability of diffraction-limited wavefront control. We describe potential observing modes of CELT, including a discussion of the several major outstanding AO system architectural design issues to be resolved prior to the initiation of the detailed design of the adaptive optics capability.

  12. Mechatronic Design - Still a Considerable Challenge

    Torry-Smith, Jonas; Qamar, Ahsan; Achiche, Sofiane


    supported through applicable methods and tools. This paper aims at identifying the major challenges, by conducting a survey of the most relevant research work in mechatronic design. Solutions proposed in literature are assessed and illustrated through a case study in order to investigate, if the challenges...... can be handled appropriately by the methods, tools, and mindsets suggested by the mechatronic community. Using a real world mechatronics case, the paper identifies the areas where further research is required, by showing a clear connection between the actual problems faced during the design task......Development of mechatronic products is traditionally carried out by several design experts from different design domains. Performing development of mechatronic products is thus greatly challenging. In order to tackle this, the critical challenges in mechatronics have to be well understood and well...

  13. A Multilevel Consideration of Service Design Conditions

    Karpen, Ingo; Gemser, Gerda; Calabretta, Giulia


    Purpose The purpose of this paper is to advance the current understanding of organisational conditions that facilitate service design. Specifically, the focus is on organisational capabilities, interactive practices and individual abilities as units of analysis across service system levels. Groun...

  14. HTGR fuel element structural design considerations

    Alloway, R.; Gorholt, W.; Ho, F.; Vollman, R.; Yu, H.


    The structural design of the large HTGR prismatic core fuel elements involve the interaction of four engineering disciplines: nuclear physics, thermo-hydraulics, structural and material science. Fuel element stress analysis techniques and the development of structural criteria are discussed in the context of an overview of the entire design process. The core of the proposed 2240 MW(t) HTGR is described as an example where the design process was used. Probabalistic stress analysis techniques coupled with probabalistic risk analysis (PRA) to develop structural criteria to account for uncertainty are described. The PRA provides a means for ensuring that the proposed structural criteria are consistent with plant investment and safety risk goals. The evaluation of cracked fuel elements removed from the Fort St. Vrain reactor in the USA is discussed in the context of stress analysis uncertainty and structural criteria development.

  15. Design consideration of solar powered cars

    Koten, Hasan; Yilmaz, Mustafa; Zafer Gul, M. [Marmara University Mechanical Engineering Department (Turkey)], E-mail:


    With the coming shortage of fossil fuels and the rising concerns over the environment, it is important to develop new technologies that reduce both energy consumption and pollution at the same time. Using solar energy is a good solution which could meet the world's energy needs. The aim of this study is to present the design process in the production of a solar powered car. Designing a solar powered car is a difficult task as there are strict requirements in term of efficiency: the car must have low drag resistance, be light-weight, and have low rolling resistance. In addition this paper presents the use of the solar powered Stirling engine technology rather than a photovoltaic conversion system for vehicle propulsion. This study presented a design process in the construction of a solar powered car and is expected to provide a new topic of research in the transportation field.

  16. Trajectory Design Considerations for Exploration Mission 1

    Dawn, Timothy F.; Gutkowski, Jeffrey P.; Batcha, Amelia L.


    Exploration Mission 1 (EM-1) will be the first mission to send an uncrewed Orion vehicle to cislunar space in 2018, targeted to a Distant Retrograde Orbit (DRO). Analysis of EM-1 DRO mission opportunities in 2018 help characterize mission parameters that are of interest to other subsystems (e.g., power, thermal, communications, flight operations, etc). Subsystems request mission design trades which include: landing lighting, addition of an Orion main engine checkout burn, and use of auxiliary thruster only cases. This paper examines the evolving trade studies that incorporate subsystem feedback and demonstrate the feasibility of these constrained mission trajectory designs and contingencies.

  17. An Analysis of Ethical Considerations in Programme Design Practice

    Govers, Elly


    Ethical considerations are inherent to programme design decision-making, but not normally explicit. Nonetheless, they influence whose interests are served in a programme and who benefits from it. This paper presents an analysis of ethical considerations made by programme design practitioners in the context of a polytechnic in Aotearoa/New Zealand.…

  18. The LACIE data bases: Design considerations

    Westberry, L. E. (Principal Investigator)


    The implementation of direct access storage devices for LACIE is discussed with emphasis on the storage and retrieval of image data. Topics covered include the definition of the problem, the solution methodology (design decisions), the initial operational structure, and the modifications which were incorporated. Some conclusions and projections of future problems to be solved are also presented.

  19. Design Considerations for Phased Array Modules


    basica )ly designed for C7 operation. In pulsed mode of oporation however, peak pov:e%.’ of 150:7 at 10.52GHz wras obtained for psoc pulse lengths and...repeating the above calculations with the appropriate value of referer:ce phase ýP applied to each element. Bearing in mind the tedious algebra involved in

  20. Section summary: Uncertainty and design considerations

    Stephen Hagen


    Well planned sampling designs and robust approaches to estimating uncertainty are critical components of forest monitoring. The importance of uncertainty estimation increases as deforestation and degradation issues become more closely tied to financing incentives for reducing greenhouse gas emissions in the forest sector. Investors like to know risk and risk is tightly...

  1. Service-Learning Instructional Design Considerations

    Maddrell, Jennifer


    This paper explores the design of "service-learning" experiences to engage college students in the real-world application of course subject matter. Service learning is an educational approach that combines community service, academic coursework, and work-based applied learning. Based on data gathered during a series of recent interviews…

  2. Service-Learning Instructional Design Considerations

    Maddrell, Jennifer


    This paper explores the design of "service-learning" experiences to engage college students in the real-world application of course subject matter. Service learning is an educational approach that combines community service, academic coursework, and work-based applied learning. Based on data gathered during a series of recent interviews…

  3. Aeroelastic Considerations in the Preliminary Design Aircraft


    DESIGN OBJECTIVES FEM FASO MODELINGWEGS TRNFRAIS SIZING RIGID AtP .FIRST FIRST FLEX FIRST FLEXSTATICLOADS [ IZING STATIC LOADS SIZING UPDATEFLEX SIZING...Structural Optimization by ASAT A computer software system called ASAT (Automatische Struktur Auslegung von Trag- flchen) exists at MBB which allows

  4. Considerations for efficient airflow design in cleanrooms

    Xu, Tengfang


    A high-performance cleanroom should provide efficient energy performance in addition to effective contamination control. Energy-efficient designs can yield capital and operational cost savings, and can be part of a strategy to improve productivity in the cleanroom industry. Based upon in-situ measurement data from ISO Class 5 clean rooms, this article discusses key factors affecting cleanroom air system performance and benefits of efficient airflow design in clean rooms. Cleanroom HVAC systems used in the semiconductor, pharmaceutical, and healthcare industries are very energy intensive, requiring large volumes of cleaned air to remove or dilute contaminants for satisfactory operations. There is a tendency, however, to design excessive airflow rates into cleanroom HVAC systems, due to factors such as design conservatism, lack of thorough understanding of airflow requirements, concerns about cleanliness reliability, and potential design and operational liabilities. Energy use of cleanroom environmental systems varies with system type and design, cleanroom functions, and the control of critical parameters such as temperature and humidity. In particular, cleanroom cleanliness requirements specified by cleanliness class have an impact on overall energy use. A previous study covering Europe and the US reveals annual cleanroom electricity usage for cooling and fan energy varies significantly depending on cleanliness class, and may account for up to three-quarters of total annual operating costs. A study on a semiconductor cleanroom in Japan found air delivery systems account for more than 30% of total power consumption. It is evident that the main factors dictating cleanroom operation energy include airflow rates and HVAC system efficiency. Improving energy efficiency in clean rooms may potentially contribute to significant savings in the initial costs of the facilities as well as operation and maintenance costs. For example, energy consumption by a typical chip

  5. Thermal expansion recovery microscopy: Practical design considerations

    Mingolo, N., E-mail:; Martínez, O. E. [Facultad de Ingeniería, Universidad de Buenos Aires, Paseo Colon 850, 1063 Buenos Aires (Argentina)


    A detailed study of relevant parameters for the design and operation of a photothermal microscope technique recently introduced is presented. The technique, named thermal expansion recovery microscopy (ThERM) relies in the measurement of the defocusing introduced by a surface that expands and recovers upon the heating from a modulated source. A new two lens design is presented that can be easily adapted to commercial infinite conjugate microscopes and the sensitivity to misalignment is analyzed. The way to determine the beam size by means of a focus scan and the use of that same scan to verify if a thermoreflectance signal is overlapping with the desired ThERM mechanism are discussed. Finally, a method to cancel the thermoreflectance signal by an adequate choice of a nanometric coating is presented.


    Norica-Felicia BUCUR


    Full Text Available Studies and articles that focus on describing and classifying foreign language syllabuses are dominated by the product / process dichotomy. Nevertheless, this is not always the case, as there are authors who, apparently, use other criteria to produce their own taxonomy. Thus, this paper attempts to provide a brief chronological outline of the various descriptions found in the syllabus design literature, so that the principles underlying the proposed taxonomies could be identified and critical comparisons could be performed.

  7. Controller Design Considerations for ACM APFC Systems

    Alexander Abramovitz


    Full Text Available This paper is concerned with performance of the current shaping network in Average Current Mode (ACM Active Power Factor Correction (APFC systems. Theoretical expressions for the ripple components are derived. Then, ripple interaction and impact on the current loop reference signal are investigated. A modification of the controller network is suggested that results in an improved Total Harmonic Distortion (THD. Design guidelines are suggested. The theoretical predictions were validated by simulation.

  8. Physics Considerations in the Design of NCSX

    G.H. Neilson; M.C. Zarnstorff; L.P. Ku; E.A. Lazarus; P.K. Mioduszewski; M. Fenstermacher; E. Fredrickson; G.Y. Fu; A. Grossman; P.J. Heitzenroeder; R.H. Hatcher; S.P. Hirshman; S.R. Hudson; D.W. Johnson; H.W. Kugel; J.F. Lyon; R. Majeski; D.R. Mikkelsen; D.A. Monticello; B.E. Nelson; N. Pomphrey; W.T. Reiersen; A.H. Reiman; P.H. Rutherford; J.A. Schmidt; D.A. Spong; D.J. Strickler


    Compact stellarators have the potential to make steady-state, disruption-free magnetic fusion systems with beta approximately 5% and relatively low aspect ratio (R/ < 4.5) compared to most drift-optimized stellarators. Magnetic quasi-symmetry can be used to reduce orbit losses. The National Compact Stellarator Experiment (NCSX) is designed to test compact stellarator physics in a high-beta quasi-axisymmetric configuration and to determine the conditions for high-beta disruption-free operation. It is designed around a reference plasma with low ripple, good magnetic surfaces, and stability to the important ideal instabilities at beta approximately 4%. The device size, available heating power, and pulse lengths provide access to a high-beta target plasma state. The NCSX has magnetic flexibility to explore a wide range of equilibrium conditions and has operational flexibility to achieve a wide range of beta and collisionality values. The design provides space to accommodate plasma-facing components for divertor operation and ports for an extensive array of diagnostics.

  9. Wankel engines as steam expanders: design considerations

    Badr, O.; Naik, S.; O' Callaghan, P.W.; Probert, S.D. (Cranfield Inst. of Tech., Bedford (GB). Dept. of Applied Energy)


    Rotary Wankel engines offer several advantages compared with turbines and other positive-displacement machines as the expansion devices in low-power-output Rankine-cycle systems. So a Wankel expander was selected as the most appropriate device for a steam Rankine-engine, operating principally as a mini combined heat-and-power unit, providing a mechanical output of 5-20 kW. A computer-aided-design technique for selecting the optimal geometry and location of the ports of the expander is described: the computer programs are available from the authors. Lubrication and possible material combinations are also discussed. (author).

  10. Design Considerations in Capacitively Coupled Plasmas

    Song, Sang-Heon; Ventzek, Peter; Ranjan, Alok


    Microelectronics industry has driven transistor feature size scaling from 10-6 m to 10-9 m during the past 50 years, which is often referred to as Moore's law. It cannot be overstated that today's information technology would not have been so successful without plasma material processing. One of the major plasma sources for the microelectronics fabrication is capacitively coupled plasmas (CCPs). The CCP reactor has been intensively studied and developed for the deposition and etching of different films on the silicon wafer. As the feature size gets to around 10 nm, the requirement for the process uniformity is less than 1-2 nm across the wafer (300 mm). In order to achieve the desired uniformity, the hardware design should be as precise as possible before the fine tuning of process condition is applied to make it even better. In doing this procedure, the computer simulation can save a significant amount of resources such as time and money which are critical in the semiconductor business. In this presentation, we compare plasma properties using a 2-dimensional plasma hydrodynamics model for different kinds of design factors that can affect the plasma uniformity. The parameters studied in this presentation include chamber accessing port, pumping port, focus ring around wafer substrate, and the geometry of electrodes of CCP.

  11. Consideration from a PBL perspective designing a virtual workshop

    Buus, Lillian; Bygholm, Ann


    This paper is taking departure in considerations of the pedagogical and learning oriented approaches made in the process from design to evaluation of the virtual workshop; as part of the MVU tutor course. Our focus in this paper is on elaborating and discussing the pedagogical considerations...... assignments. The design has tight and clear standards concentrated within only one week, as to give the participants opportunity to generate experiences in a considerable focus of collaboration, group work and different media supporting the assignments. In this paper we will elaborate the considerations...

  12. Design considerations for parallel graphics libraries

    Crockett, Thomas W.


    Applications which run on parallel supercomputers are often characterized by massive datasets. Converting these vast collections of numbers to visual form has proven to be a powerful aid to comprehension. For a variety of reasons, it may be desirable to provide this visual feedback at runtime. One way to accomplish this is to exploit the available parallelism to perform graphics operations in place. In order to do this, we need appropriate parallel rendering algorithms and library interfaces. This paper provides a tutorial introduction to some of the issues which arise in designing parallel graphics libraries and their underlying rendering algorithms. The focus is on polygon rendering for distributed memory message-passing systems. We illustrate our discussion with examples from PGL, a parallel graphics library which has been developed on the Intel family of parallel systems.

  13. Digital libraries philosophies, technical design considerations, and example scenarios

    Stern, David


    An unparalleled overview of current design considerations for your digital library! Digital Libraries: Philosophies, Technical Design Considerations, and Example Scenarios is a balanced overview of public services, collection development, administration, and systems support, for digital libraries, with advice on adopting the latest technologies that appear on the scene. As a professional in the library and information science field, you will benefit from this special issue that serves as an overview of selected directions, trends, possibilities, limitations, enhancements, design principals, an

  14. Design considerations for partial neutralization acid injection

    Perl, T.R.; Van der Cook, R.E.


    It is currently estimated that, after vacuum evaporator-crystallizer of Hanford liquid wastes on the order of 10 million gallons of caustic residual liquor will remain. Partial Neutralization, the continuous addition of nitric acid to the slurry is being developed to allow additional volume reduction and reduce interim storage costs. Tests revealed that acid and liquor compositions as well as nozzle design are significant factors in the concentration of NO/sub x/ in the mild steel vessel vent system. The available literature information relating to mixing of up to 20 gallons per minute of acid with 14,000 gallons per minute of slurry is presented. Very rapid and thorough mixing of the injected acid is required, since reaction of even 0.1 percent of the injected acid with sodium nitrite in the slurry would yield unacceptable levels of NO/sub x/ in the vessel vent system. The mixing time calculated by a method developed herein was used to evaluate the proposed conceptual mixing nozzle.

  15. Design Considerations for Proposed Fermilab Integrable RCS

    Eldred, Jeffrey [Fermilab; Valishev, Alexander


    Integrable optics is an innovation in particle accelerator design that provides strong nonlinear focusing while avoiding parametric resonances. One promising application of integrable optics is to overcome the traditional limits on accelerator intensity imposed by betatron tune-spread and collective instabilities. The efficacy of high-intensity integrable accelerators will be undergo comprehensive testing over the next several years at the Fermilab Integrable Optics Test Accelerator (IOTA) and the University of Maryland Electron Ring (UMER). We propose an integrable Rapid-Cycling Synchrotron (iRCS) as a replacement for the Fermilab Booster to achieve multi-MW beam power for the Fermilab high-energy neutrino program. We provide a overview of the machine parameters and discuss an approach to lattice optimization. Integrable optics requires arcs with integer-pi phase advance followed by drifts with matched beta functions. We provide an example integrable lattice with features of a modern RCS - long dispersion-free drifts, low momentum compaction, superperiodicity, chromaticity correction, separate-function magnets, and bounded beta functions.

  16. Planetary Protection Considerations in EVA System Design

    Eppler, Dean B.; Kosmo, Joseph J.


    very little expression of these anomalies. hardware from the human-occupied area may limit (although not likely eliminate) external materials in the human habitat. Definition of design-to requirements is critical to understanding technical feasibility and costs. The definition of Planetary Protection needs in relation to EVA mission and system element development cost impacts should be considered and interpreted in terms of Plausible Protection criteria. Since EVA operations will have the most direct physical interaction with the Martian surface, PP needs should be considered in the terms of mitigating hardware and operations impacts and costs.

  17. Primary ciliary dyskinesia: considerations regarding six cases of Kartagener syndrome.

    Ortega, Hugo Alejandro Vega; Vega, Nelson de Araujo; Santos, Bruno Quirino Dos; Maia, Guilherme Tavares da Silva


    Primary ciliary dyskinesia (PCD), previously known as immotile cilia syndrome, is an autosomal recessive hereditary disease that includes various patterns of ciliary ultrastructural defects. The most serious form is Kartagener syndrome (KS), which accounts for 50% of all cases of PCD. The incidence of PCD ranges from 1:20,000 to 1:60,000. Since PCD causes deficiency or even stasis of the transport of secretions throughout the respiratory tract, it favors the growth of viruses and bacteria. As a result, patients have lifelong chronic and recurrent infections, typically suffering from bronchitis, pneumonia, hemoptysis, sinusitis, and infertility. Bronchiectasis and other chronic conditions infections can be the end result of the irreversible bronchial alterations, leading to chronic cor pulmonale and its consequences. Only half of the patients affected by PDC present all of the symptoms, a condition designated complete KS, compared with incomplete KS, typically defined as cases in which situs inversus does not occur. The diagnosis is made clinically and confirmed through transmission electron microscopy. Since there is no specific therapy for PCD, it is recommended that, upon diagnosis, secondary infections be treated with potent antibiotics and prophylactic interventions be implemented. In this paper, we report six cases of PCD (five cases of complete KS and one case of KS) and review the related literature, focusing on the diagnostic, therapeutic and clinical aspects of this disease.

  18. Clinical and imaging considerations in primary immunodeficiency disorders: an update

    Wu, Eveline Y. [University of North Carolina at Chapel Hill, Department of Pediatrics, Chapel Hill, NC (United States); Ehrlich, Lauren [Yale School of Medicine, Department of Diagnostic Radiology, New Haven, CT (United States); Handly, Brian [University of North Carolina at Chapel Hill, Department of Radiology, Chapel Hill, NC (United States); Frush, Donald P. [Duke University Medical Center, Division of Pediatric Radiology, Durham, NC (United States); Buckley, Rebecca H. [Duke University Medical Center, Department of Pediatrics, Durham, NC (United States); Duke University School of Medicine, Department of Immunology, Durham, NC (United States)


    Primary immunodeficiencies are a group of genetically determined disorders with diverse presentations. The purpose of this review is to provide a practical and brief description of a select number of these diseases and to discuss the important role the radiologist can have in making an early diagnosis and in detecting and following disease complications. The role of diagnostic imaging and informed performance and interpretation are vital in the diagnosis, surveillance and management of all primary immunodeficiency disorders. (orig.)

  19. Probe interface design consideration. [for interplanetary spacecraft missions

    Casani, E. K.


    Interface design between a probe and a spacecraft requires not only technical considerations but also management planning and mission analysis interactions. Two further aspects of importance are the flyby versus the probe trade-off, and the relay link design and data handling optimization.

  20. Four Major Considerations of a Business English Curriculum Design

    GUO Jing


    Business English(BE)in China is developing in an amazing speed, yet no consensus on curriculum design is reached. This paper reviews the history of Business English development both in and out of China, and gives four major considerations of the curriculum design of Business English for BA level.

  1. Research design considerations for chronic pain prevention clinical trials

    Gewandter, Jennifer S; Dworkin, Robert H; Turk, Dennis C


    Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations...... for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment...... element exposure), and are chronically painful conditions that are treated with a range of interventions. Improvements in the design of chronic pain prevention trials could improve assay sensitivity and thus accelerate the identification of efficacious interventions. Such interventions would have...

  2. Primary cell culture of human adenocarcinomas--practical considerations.

    Lerescu, Lucian; Tucureanu, Cătălin; Caraş, Iuliana; Neagu, Stefan; Melinceanu, Laura; Sălăgeanu, Aurora


    Cell culture is one of the major tools for oncology research, being an excellent system in which to study the biochemistry and molecular biology associated with individual cancer types and to understand cancer cell physiology. Progress in understanding the biology of any type of carcinoma has been impeded by the inability to culture adequately malignant cells from most epithelial tissues. The ultimate in vitro tumor model would completely reflect the in vivo tumor microenvironment in function and mechanism. Unfortunately, such a model does not currently exist. Homogeneous cell lines that can be continuously propagated on plastic surfaces have been extensively used as a surrogate for tumor environment; however they are very different from the in vivo tumor cells. Model systems involving primary culture represent the situation most closely related to the original tissue although they have a number of disadvantages over cell lines, such as the limited ability to repeat studies with a well characterized culture system that can be used in multiple laboratories. The primary culture may contain many types of stromal and infiltrating cell types potentially complicating the interpretation of data. Yet, their properties better reflect the cellular interactions present in intact tissue. The present article reviews the critical steps in obtaining, routine maintenance and cryopreservation of primary tumor cell cultures, based on information from literature and personal experience on the subject. The article also includes an updated protocol for primary tumor cell isolation and culture.

  3. Design Considerations for Hydropower Development In a Water Distribution System

    DavidP.Chamberlain; EdStewart; Fei-FanYeh; MichaelT.Stift


    Installation of a hydraulic turbine in a water distribution system involving long pipeline reaches requires several unique design considerations. For a fixed speed unit, the selection of design points for head and flow needs to be optimized to provide an operating envelope that would maximize the return on the investment given the widely varied flow and pressure conditions imposed by the water distribution system. The selection of a turbine design speed is essential in facilitating runner design, which must minimize the hydraulic pressure transients on turbine runaway that may result in overstressing the existing pipelines. Method and approach to evaluate these considerations are outlined. Relevant results for the selected design are presented using the 4.3 MW Rancho Penasquitos Pressure Control/Hydroelectric Facility as an illustrative example. Licensing requirements for small inline hydroelectric facilities are also briefly discussed.

  4. Recent advances and design considerations in capping systems

    DiPippo, G.J.; Monteleone, M.J. [Eckenfelder Inc., Mahwah, NJ (United States)


    Capping systems for solid and hazardous waste management facilities and remedial applications have changed significantly over the years. Early designs were virtually monolithic, with little specification of functional properties. The evolution of capping systems has continued and was hastened by the application of geosynthetics and the diligence of those working in the industry in understanding the design considerations for and performance of various capping materials. Capping systems continue to evolve particularly with respect to the application and understanding of the geosynthetic components. Today the design of an effective cap with a total thickness of two feet, or even less as is discussed further below, is possible. Yet much more work remains in various areas such as more precise means of assessing stability, the effects of strain softening, design using seismic considerations, and the like. This paper describes various recent advances in cap design. Three of these advances are covered in some detail; namely, geosynthetic clay layers, subdrainage design using high capacity geonets, and a thin cap section using direct asphalt overlay of geosynthetics for industrial site applications. Several other advances and design considerations are more briefly addressed to illustrate the breadth of the evolution of capping systems.

  5. [Primary empty sella. Clinico-radiologic considerations in 18 cases].

    Pompili, A; Jachetti, M; Carapella, C M; Crecco, M; Gaudino, G; Isabella, F; Mastrostefano, R


    18 patients with "primary empty sella" were reviewed for this study. In 3 of them the sellar enlargement was discovered occasionally by performing skull radiographs for other reasons. The galattorrhea-dismenorrhea or amenorrhea syndrome and obesity were the most common clinical features. Endocrinological tests were normal in ten patients and abnormal in eight. Slight elevation of serum PRL was the most common record. 12 patients had enlarging of the sella turcica; in 4, only the floor was asymmetric and in 2 the sella was quite normal. In 5 patients C.T. without intra-thecal contrast was sufficient to discover the E.S. In 13 patients we performed C.T. cysternography by injecting in the lumbar subarachnoid space 8-10 ml of Iopamidolo 200. This is an excellent and safe technique to perform C.T. cysternography.

  6. Spectrum analysis on quality requirements consideration in software design documents.

    Kaiya, Haruhiko; Umemura, Masahiro; Ogata, Shinpei; Kaijiri, Kenji


    Software quality requirements defined in the requirements analysis stage should be implemented in the final products, such as source codes and system deployment. To guarantee this meta-requirement, quality requirements should be considered in the intermediate stages, such as the design stage or the architectural definition stage. We propose a novel method for checking whether quality requirements are considered in the design stage. In this method, a technique called "spectrum analysis for quality requirements" is applied not only to requirements specifications but also to design documents. The technique enables us to derive the spectrum of a document, and quality requirements considerations in the document are numerically represented in the spectrum. We can thus objectively identify whether the considerations of quality requirements in a requirements document are adapted to its design document. To validate the method, we applied it to commercial software systems with the help of a supporting tool, and we confirmed that the method worked well.

  7. Monitoring Conceptual Development: Design Considerations of a Formative Feedback tool

    Berlanga, Adriana; Smithies, Alisdair; Braidman, Isobel; Wild, Fridolin


    Berlanga, A. J., Smithies, A., Braidman, I., & Wild, F. (2010, 15 September). Monitoring Conceptual Development: Design Considerations of a Formative Feedback Tool. Presentation at the Interactive Computer Aided Learning Conference (ICL 2010), Track on Computer-based Knowledge & Skill Assessment and

  8. Lunar Module Electrical Power System Design Considerations and Failure Modes

    Interbartolo, Michael


    This slide presentation reviews the design and redesign considerations of the Apollo lunar module electrical power system. Included in the work are graphics showing the lunar module power system. It describes the in-flight failures, and the lessons learned from these failures.

  9. The Design Consideration for Game-Based Learning

    Liang, Chaoyun; Lee, Yuan-Zone; Chou, Wen-Shou


    The integration of game playing with online education has recently become one of the most discussed issues in the e-learning field for its potentially positive impact on the development of related industries and on the social lives of young people. In this article, the authors propose a set of design considerations to assist game-based learning…

  10. Considerations in designing an evaluation system for adaptive delta management

    Hermans, L.M.; Maat, J.; Haasnoot, M.; Kwakkel, J.H.


    New planning approaches put new requirements on evaluation. A recent innovation in the water domain is adaptive delta management (ADM). ADM supports long-term planning in the face of uncertainty. This paper discusses the main considerations for the design of an evaluation system for ADM, departing f

  11. Primary products and mechanistic considerations in alkane metathesis.

    Basset, Jean Marie; Copéret, Christophe; Lefort, Laurent; Maunders, Barry M; Maury, Olivier; Le Roux, Erwan; Saggio, Guillaume; Soignier, Sophie; Soulivong, Daravong; Sunley, Glenn J; Taoufik, Mostafa; Thivolle-Cazat, Jean


    Alkane metathesis, a reaction catalyzed by the silica-supported tantalum hydride [(SiO)2Ta-H], 1, which transforms acyclic alkanes into their higher and lower homologues, was reported in 1997. New studies conducted in a continuous flow reactor in the case of propane indicate that, by varying the contact time, hydrogen and olefins are primary products. This crucial observation, as well as the known properties of tantalum alkyls to perform alpha-H or beta-H eliminations, supports the proposition of a new mechanism involving metallacyclobutane intermediates just like in olefin metathesis. The observed selectivities for linear and branched Cn+1 and Cn+2 products as well as the linear/branched ratio can be well-explained on the basis of the minimization of steric interactions between 1,2- or 1,3-substituents in the various tantallacyclobutane intermediates or during their formation. Hydrogen plays a specific role in the cleavage of metal alkyls to complete the catalytic cycle.

  12. Design considerations for energy efficient, resilient, multi-layer networks

    Fagertun, Anna Manolova; Hansen, Line Pyndt; Ruepp, Sarah Renée


    This work investigates different network design considerations with respect to energy-efficiency, under green-field resilient multi-layer network deployment. The problem of energy efficient, reliable multi-layer network design is known to result in different trade-offs between key performance...... in multi-layer networks and performance measures such as network resource utilization, availability, agility to traffic fluctuations and energy consumption. A green-field network deployment scenario is considered, where different resiliency methods, design methodologies and grooming strategies are applied...

  13. Design Considerations for a Flexible Multigrid Preconditioning Library

    Jérémie Gaidamour


    Full Text Available MueLu is a library within the Trilinos software project [An overview of Trilinos, Technical Report SAND2003-2927, Sandia National Laboratories, 2003] and provides a framework for parallel multigrid preconditioning methods for large sparse linear systems. While providing efficient implementations of modern multigrid methods based on smoothed aggregation and energy minimization concepts, MueLu is designed to be customized and extended. This article gives an overview of design considerations for the MueLu package: user interfaces, internal design, data management, usage of modern software constructs, leveraging Trilinos capabilities, linear algebra operations and advanced application.

  14. Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints

    Thompson, Mary Kathryn; Moroni, Giovanni; Vaneker, Tom


    The past few decades have seen substantial growth in Additive Manufacturing (AM) technologies. However, this growth has mainly been process-driven. The evolution of engineering design to take advantage of the possibilities afforded by AM and to manage the constraints associated with the technology...... has lagged behind. This paper presents the major opportunities, constraints, and economic considerations for Design for Additive Manufacturing. It explores issues related to design and redesign for direct and indirect AM production. It also highlights key industrial applications, outlines future...

  15. Flexible design should be primary goal.


    At "Rebuilding the NHS", a recent Health Service Journal conference in London, Daryl Murphy, a partner at leading architect and health planning specialist for the primary and community care sectors Murphy Philipps, explained how the Department of Health's (DH's) forthcoming HBN 11-01 Health Building Note sets out a "less prescriptive approach" to the design of new primary care and community healthcare facilities.

  16. NIF ReShock/Shear Photometrics Design Considerations

    Flippo, Kirk Adler [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    The design of the photometrics for the NIF Shock/Shear campaign was driven by three linked considerations: the backlighter (BL) material had to be chosen such that it’s He-α emission line gave high enough contrast to measure mix width and see the shock propagation in the target wall, the BL beam geometry had to give sufficient BL spot dimensions and intensity to produce a uniform He-α radiograph of the target, and the BL/pinhole system had to have a high enough resolution and signal to be able to measure the quantities of interest. The design considerations are linked such that the required contrast determines the BL material, the BL material determines what laser intensity range is need for He-α emission, and the resulting He-α emission intensity helps determine whether or not there will be sufficient signal for analysis.

  17. Design considerations and operational performance of Anaerobic Digester: A Review

    Muzaffar Ahmad Mir


    Full Text Available Due to the decline in fossil fuel reservoirs, the researchers emphasized more on the production of biogas from organic waste. Producing the renewable energy from biodegradable waste helps to overcome the energy crisis and solid waste management, done by anaerobic digestion. Anaerobic digestion is controlled breakdown of organic matter into methane gas (60%, carbon dioxide (40%, trace components along with digested used as soil conditioner. However there is vast dearth of literature regarding the design considerations. The batch digestion system yields a cost-effective and economically viable means for conversion of the food waste to useful energy. It is therefore recommended that such process can be increasingly employed in order to get and simultaneously protect the environment .This paper aims to draw key analysis and concern about the design considerations, analysis of gas production, substrates and inoculums utilization, uses and impacts of biogas.

  18. Biomechanics of injury prediction for anthropomorphic manikins - preliminary design considerations

    Engin, A.E. [Univ. of South Alabama, Mobile, AL (United States)


    The anthropomorphic manikins are used in automobile safety research as well as in aerospace related applications. There is now a strong need to advance the biomechanics knowledge to determine appropriate criteria for injury likelihood prediction as functions of manikin-measured responses. In this paper, three regions of a manikin, namely, the head, knee joint, and lumbar spine are taken as examples to introduce preliminary design considerations for injury prediction by means of responses of theoretical models and strategically placed sensing devices.

  19. The design considerations for a superconducting magnetic bearing system

    Cansiz, Ahmet; Yildizer, Irfan


    In this paper a high temperature superconducting magnetic bearing is studied with various design considerations. The design of the bearing consists of a rotor with 7.5 kg mass. The stable levitation of the rotor is provided with the Evershed type and superconducting components. The dynamic stability of the rotor is strengthened with the electromagnetic and electrodynamic levitation techniques. The force on the rotor is predicted in terms of semi-analytical frozen image model. The designed driving system sustains stable levitation during the rotation of the rotor and achieves higher rotational speed than that of the torque driver. The results indicate that the designed rotor and driving system have potential solutions for the development of the superconducting flywheel energy storage.

  20. Design considerations for post accident monitoring system of a research reactor

    Jang, Gwi Sook; Park, Je Yun; Kim, Young Ki [KAERI, Daejeon (Korea, Republic of)


    The Post Accident Monitoring System (PAMS) provides primary information for operators to assess the plant conditions and perform their role in bringing the plant to a safe condition during an accident. The PAMS of NPP (Nuclear Power Plant) in KOREA provides the continuous display of the PAM category 1 parameters specified in R.G 1.97, Rev. 03. Recently the PAMS of NPP has been designed according to R.G 1.97, Rev. 04. There is no PAMS at the HANARO in KOREA, but recently RRs (Research Reactors) around the world are going to have PAMS for various multi purposes. We should determine the design considerations for PAMS in a Korean RR based on the design state analysis. Thus, this paper proposes strategies on the design considerations for the PAMS of a Korean RR.


    BARSAN Lucian


    Full Text Available The paper presents some considerations about the necessity of evaluating the environmental impact of a product during its entire life. The present situation (economic, social and ecologic imposes solutions to reduce this impact as a result of an analysis performed during all stages of the life cycle. This paper focuses on design solutions with consequences in the last stage, the end-of-life. Reusing products, with, or without remanufacturing and recycling the materials from products that cannot be reused represent some options analysed in this paper. The end-of-life options should be known even from the beginning of the design process and should be included as design objectives or, at least as constrictions. Considering them as human needs would naturally include them in the requirements list.

  2. Design considerations for fume hoods for process plants.

    Goodfellow, H D; Bender, M


    Proper design of fume hoods is a necessary requisite for a clean working environment for many industrial processes. Until recently, the design of these hoods has been rather a trial and error approach and not based on sound engineering design principles. Hatch Associates have developed and applied new techniques to establish hood parameters for different industrail processes. The paper reviews the developed techniques and illustrates practical application of these techniques to the solving of difficult and comples fume hood design and operating performance problems. The scope of the paper covers the following subject areas: definitions and general considerations: evaluation of volume and heat flow rates for emission sources; local capture of process emissions; remote capture of process emissions and case studies of fume hood applications. The purpose of the paper is to detail a coherent approach in the analysis of emission problems which will result in the development of an efficient design of a fume capture hood. An efficient fume hood can provide a safe working place as well as a clean external environment. Although the techniques can be applied to smaller sources, the case studies which will be examined will be for fume hoods in the flow design range of 50 000 CFM to +1 000 000 CFM.

  3. Design Considerations For Blast Loads In Pressure Vessels.

    Rodriguez, E. A. (Edward A.); Nickell, Robert E.; Pepin, J. E. (Jason E.)


    Los Alamos National Laboratory (LANL), under the auspices of the U.S. Department of Energy (DOE) and the National Nuclear Security Administration (NNSA), conducts confined detonation experiments utilizing large, spherical, steel pressure vessels to contain the reaction products and hazardous materials from high-explosive (HE) events. Structural design and analysis considerations include: (a) Blast loading phase (i.e., impulsive loading); (b) Dynamic structural response; (c) Fragment (i.e., shrapnel) generation and penetration; (d) Ductile and non-ductile fracture; and (e) Design Criteria to ASME Code Sec. VIII, Div. 3, Impulsively Loaded Vessels. These vessels are designed for one-time-use only, efficiently utilizing the significant plastic energy absorption capability of ductile vessel materials. Alternatively, vessels may be designed for multiple-detonation events, in which case the material response is restricted to elastic or near-elastic range. Code of Federal Regulations, Title 10 Part 50 provides requirements for commercial nuclear reactor licensing; specifically dealing with accidental combustible gases in containment structures that might cause extreme loadings. The design philosophy contained herein may be applied to extreme loading events postulated to occur in nuclear reactor and non-nuclear systems or containments.

  4. Carbon Taxes: A Review of Experience and Policy Design Considerations

    Sumner, J.; Bird, L.; Smith, H.


    State and local governments in the United States are evaluating a wide range of policies to reduce carbon emissions, including, in some instances, carbon taxes, which have existed internationally for nearly 20 years. This report reviews existing carbon tax policies both internationally and in the United States. It also analyzes carbon policy design and effectiveness. Design considerations include which sectors to tax, where to set the tax rate, how to use tax revenues, what the impact will be on consumers, and how to ensure emissions reduction goals are achieved. Emission reductions that are due to carbon taxes can be difficult to measure, though some jurisdictions have quantified reductions in overall emissions and other jurisdictions have examined impacts that are due to programs funded by carbon tax revenues.

  5. Carbon Taxes. A Review of Experience and Policy Design Considerations

    Sumner, Jenny [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Smith, Hillary [National Renewable Energy Lab. (NREL), Golden, CO (United States)


    State and local governments in the United States are evaluating a wide range of policies to reduce carbon emissions, including, in some instances, carbon taxes, which have existed internationally for nearly 20 years. This report reviews existing carbon tax policies both internationally and in the United States. It also analyzes carbon policy design and effectiveness. Design considerations include which sectors to tax, where to set the tax rate, how to use tax revenues, what the impact will be on consumers, and how to ensure emissions reduction goals are achieved. Emission reductions that are due to carbon taxes can be difficult to measure, though some jurisdictions have quantified reductions in overall emissions and other jurisdictions have examined impacts that are due to programs funded by carbon tax revenues.

  6. Design Considerations for a Launch Vehicle Development Flight Instrumentation System

    Johnson, Martin L.; Crawford, Kevin


    When embarking into the design of a new launch vehicle, engineering models of expected vehicle performance are always generated. While many models are well established and understood, some models contain design features that are only marginally known. Unfortunately, these analytical models produce uncertainties in design margins. The best way to answer these analytical issues is with vehicle level testing. The National Aeronautics and Space Administration respond to these uncertainties by using a vehicle level system called the Development Flight Instrumentation, or DFI. This DFI system can be simple to implement, with only a few measurements, or it may be a sophisticated system with hundreds of measurement and video, without a recording capability. From experience with DFI systems, DFI never goes away. The system is renamed and allowed to continue, in most cases. Proper system design can aid the transition to future data requirements. This paper will discuss design features that need to be considered when developing a DFI system for a launch vehicle. It will briefly review the data acquisition units, sensors, multiplexers and recorders, telemetry components and harnessing. It will present a reasonable set of requirements which should be implemented in the beginning of the program in order to start the design. It will discuss a simplistic DFI architecture that could be the basis for the next NASA launch vehicle. This will be followed by a discussion of the "experiences gained" from a past DFI system implementation, such as the very successful Ares I-X test flight. Application of these design considerations may not work for every situation, but they may direct a path toward success or at least make one pause and ask the right questions.

  7. System design considerations for fast-neutron interrogation systems

    Micklich, B.J.; Curry, B.P.; Fink, C.L.; Smith, D.L.; Yule, T.J.


    Nonintrusive interrogation techniques that employ fast neutrons are of interest because of their sensitivity to light elements such as carbon, nitrogen, and oxygen. The primary requirement of a fast-neutron inspection system is to determine the value of atomic densities, or their ratios, over a volumetric grid superimposed on the object being interrogated. There are a wide variety of fast-neutron techniques that can provide this information. The differences between the various nuclear systems can be considered in light of the trade-offs relative to the performance requirements for each system`s components. Given a set of performance criteria, the operational requirements of the proposed nuclear systems may also differ. For instance, resolution standards will drive scanning times and tomographic requirements, both of which vary for the different approaches. We are modelling a number of the fast-neutron interrogation techniques currently under consideration, to include Fast Neutron Transmission Spectroscopy (FNTS), Pulsed Fast Neutron Analysis (PFNA), and its variant, 14-MeV Associated Particle Imaging (API). The goals of this effort are to determine the component requirements for each technique, identify trade-offs that system performance standards impose upon those component requirements, and assess the relative advantages and disadvantages of the different approaches. In determining the component requirements, we will consider how they are driven by system performance standards, such as image resolution, scanning time, and statistical uncertainty. In considering the trade-offs between system components, we concentrate primarily on those which are common to all approaches, for example: source characteristics versus detector array requirements. We will then use the analysis to propose some figures-of-merit that enable performance comparisons between the various fast-neutron systems under consideration. The status of this ongoing effort is presented.

  8. Considerations of Dance Transmission Processes: Adapting Bharata Natyam in a Singapore Primary School

    Lum, Chee Hoo; Gonda, Donn Emmanuel


    This qualitative case study has, for its purpose, an examination of the pedagogies and practices of a master Bharata Natyam dance instructor working within a Singapore primary school context. It explores the instructor's adaptation within an after-school weekly activity of the South Indian traditional classical dance form. Considerations of dance…

  9. Considerations of Dance Transmission Processes: Adapting Bharata Natyam in a Singapore Primary School

    Lum, Chee Hoo; Gonda, Donn Emmanuel


    This qualitative case study has, for its purpose, an examination of the pedagogies and practices of a master Bharata Natyam dance instructor working within a Singapore primary school context. It explores the instructor's adaptation within an after-school weekly activity of the South Indian traditional classical dance form. Considerations of…

  10. System Design Considerations In Bar-Code Laser Scanning

    Barkan, Eric; Swartz, Jerome


    The unified transfer function approach to the design of laser barcode scanner signal acquisition hardware is considered. The treatment of seemingly disparate system areas such as the optical train, the scanning spot, the electrical filter circuits, the effects of noise, and printing errors is presented using linear systems theory. Such important issues as determination of depth of modulation, filter specification, tolerancing of optical components, and optimi-zation of system performance in the presence of noise are discussed. The concept of effective spot size to allow for impact of optical system and analog processing circuitry upon depth of modulation is introduced. Considerations are limited primarily to Gaussian spot profiles, but also apply to more general cases. Attention is paid to realistic bar-code symbol models and to implications with respect to printing tolerances.

  11. Primary battery design and safety guidelines handbook

    Bragg, Bobby J.; Casey, John E.; Trout, J. Barry


    This handbook provides engineers and safety personnel with guidelines for the safe design or selection and use of primary batteries in spaceflight programs. Types of primary batteries described are silver oxide zinc alkaline, carbon-zinc, zinc-air alkaline, manganese dioxide-zionc alkaline, mercuric oxide-zinc alkaline, and lithium anode cells. Along with typical applications, the discussions of the individual battery types include electrochemistry, construction, capacities and configurations, and appropriate safety measures. A chapter on general battery safety covers hazard sources and controls applicable to all battery types. Guidelines are given for qualification and acceptance testing that should precede space applications. Permissible failure levels for NASA applications are discussed.

  12. Methodologic issues, theoretical considerations, and design criteria for experimental animal and cell culture experiments.

    Birt, D F


    This article provides background information that is important when evaluating the relevance to humans of particular animal or in vitro experiments designed to assess the relations between fatty acids and cancer. Considerations in designing carcinogenesis studies to assess the relation between dietary fatty acids and human cancer include selection of the animal model and design of the experimental diets. Animal carcinogenesis models are generally best for evaluating the early phases of cancer development: the initiation and promotion of cancer. Transplantation protocols have been developed for evaluating the effect of diet on the growth and metastasis of partially or fully transformed cells. The variables that are important in such models are the origin and biology of the cell line, the animal host used for the implantation, the site of transplantation, whether the primary tumor is excised after a period of time to allow for metastasis, and when the diets are fed relative to the different phases of tumor growth and metastasis. Studies in cultured cells have been particularly useful for assessing the mechanisms by which fatty acids affect cancer. Considerations in designing studies with cultured cells include selection of the cell line, cell culture conditions, selection of biological endpoints that are relevant to human cancer, and in vivo confirmation of the mechanisms observed in vitro. Design considerations for each of these experimental approaches are discussed and the contributions of each approach are summarized.

  13. Design considerations for joints in deployable space truss structures

    Rhodes, Marvin D.


    All of the structures considered for the Control of Flexible Structures (COFS) flight experiments are deployable truss structures and their response will be dominated by the structural response of the joints. To prepare for these experiments some fundamental research work is being conducted in the Structures and Dynamics Division at LaRC which will provide insight into structurally efficient and predictable deployable truss joints. This work involves generic studies of the static and dynamic response of joints as well as the development of analytical models which can be used to predict the response of a large multijointed truss. In addition to the generic joint studies, the research effort encompasses the design and fabrication of a 20-meter long deployable truss beam for laboratory evaluation of its structural characteristics and correlation with developed prediction methods. The experimental results have indicated the importance of attention to detail in the design and fabrication of joints for deployable truss structures. The dimensional relations and material considerations for efficient pin-clevis joints have been outlined. Results of tests on the near-center latch are discussed.

  14. Standard guide for general design considerations for hot cell equipment

    American Society for Testing and Materials. Philadelphia


    1.1 Intent: 1.1.1 The intent of this guide is to provide general design and operating considerations for the safe and dependable operation of remotely operated hot cell equipment. Hot cell equipment is hardware used to handle, process, or analyze nuclear or radioactive material in a shielded room. The equipment is placed behind radiation shield walls and cannot be directly accessed by the operators or by maintenance personnel because of the radiation exposure hazards. Therefore, the equipment is operated remotely, either with or without the aid of viewing. 1.1.2 This guide may apply to equipment in other radioactive remotely operated facilities such as suited entry repair areas, canyons or caves, but does not apply to equipment used in commercial power reactors. 1.1.3 This guide does not apply to equipment used in gloveboxes. 1.2 Applicability: 1.2.1 This guide is intended for persons who are tasked with the planning, design, procurement, fabrication, installation, or testing of equipment used in rem...

  15. Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

    Gewandter, Jennifer S; Dworkin, Robert H; Turk, Dennis C; Farrar, John T; Fillingim, Roger B; Gilron, Ian; Markman, John D; Oaklander, Anne Louise; Polydefkis, Michael J; Raja, Srinivasa N; Robinson, James P; Woolf, Clifford J; Ziegler, Dan; Ashburn, Michael A; Burke, Laurie B; Cowan, Penney; George, Steven Z; Goli, Veeraindar; Graff, Ole X; Iyengar, Smriti; Jay, Gary W; Katz, Joel; Kehlet, Henrik; Kitt, Rachel A; Kopecky, Ernest A; Malamut, Richard; McDermott, Michael P; Palmer, Pamela; Rappaport, Bob A; Rauschkolb, Christine; Steigerwald, Ilona; Tobias, Jeffrey; Walco, Gary A


    Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment, outcomes, timing of assessment, and adjusting for risk factors in the analyses. We provide a detailed examination of 4 models of chronic pain prevention (ie, chronic postsurgical pain, postherpetic neuralgia, chronic low back pain, and painful chemotherapy-induced peripheral neuropathy). The issues discussed can, in many instances, be extrapolated to other chronic pain conditions. These examples were selected because they are representative models of primary and secondary prevention, reflect persistent pain resulting from multiple insults (ie, surgery, viral infection, injury, and toxic or noxious element exposure), and are chronically painful conditions that are treated with a range of interventions. Improvements in the design of chronic pain prevention trials could improve assay sensitivity and thus accelerate the identification of efficacious interventions. Such interventions would have the potential to reduce the prevalence of chronic pain in the population. Additionally, standardization of outcomes in prevention clinical trials will facilitate meta-analyses and systematic reviews and improve detection of preventive strategies emerging from clinical trials.

  16. Quasi-experimental designs in practice-based research settings: design and implementation considerations.

    Handley, Margaret A; Schillinger, Dean; Shiboski, Stephen


    Although randomized controlled trials are often a gold standard for determining intervention effects, in the area of practice-based research (PBR), there are many situations in which individual randomization is not possible. Alternative approaches to evaluating interventions have received increased attention, particularly those that can retain elements of randomization such that they can be considered "controlled" trials. Methodological design elements and practical implementation considerations for two quasi-experimental design approaches that have considerable promise in PBR settings--the stepped-wedge design, and a variant of this design, a wait-list cross-over design, are presented along with a case study from a recent PBR intervention for patients with diabetes. PBR-relevant design features include: creation of a cohort over time that collects control data but allows all participants (clusters or patients) to receive the intervention; staggered introduction of clusters; multiple data collection points; and one-way cross-over into the intervention arm. Practical considerations include: randomization versus stratification, training run in phases; and extended time period for overall study completion. Several design features of practice based research studies can be adapted to local circumstances yet retain elements to improve methodological rigor. Studies that utilize these methods, such as the stepped-wedge design and the wait-list cross-over design, can increase the evidence base for controlled studies conducted within the complex environment of PBR.

  17. Design consideration for design a flat and ring plastics part using Solidworks software

    Amran, M. A. M.; Faizal, K. M.; Salleh, M. S.; Sulaiman, M. A.; Mohamad, E.


    Various considerations on design of plastic injection moulded parts were applied in initial stage to prevent any defects of end products. Therefore, the objective of this project is to design the plastic injection moulded part by taking consideration on several factors such as draft angle, corner radius and location of gate. In this project, flat plastic part, ring plastic part, core inserts for flat and ring plastic part were designed using SolidWorks software. The plastic part was drawn in sketching mode then the 3D modeling of solid part was generated using various commands. Considerations of plastic part such as draft angle and corner radius with location of gate was considered in the design stage. Finally, it was successfully designed the two plastic parts with their respectively insert by using SolidWorks software. The flat plastic part and ring plastic part were designed for the purpose for future researches for study the weld lines, meld lines, air trapped and geometrical size of the product. Thus, by designing the flat plastic part and ring plastic part having core insert on each part, the completed mould design of two plate mould can be considered. This is because, plastic injection parts are needed to be designed properly in order to neglect any defect when the mould was made.

  18. Design Considerations for Space Transfer Vehicles Using Solar Thermal Propulsion

    Emrich, William J.


    The economical deployment of satellites to high energy earth orbits is crucial to the ultimate success of this nations commerical space ventures and is highly desirable for deep space planetary missions requiring earth escape trajectories. Upper stage space transfer vehicles needed to accomplish this task should ideally be simple, robust, and highly efficient. In this regard, solar thermal propulsion is particularly well suited to those missions where high thrust is not a requirement. The Marshall Space Flight Center is , therefore, currently engaged in defining a transfer vehicle employing solar thermal propulsion capable of transferring a 1000 lb. payload from low Earth orbit (LEO) to a geostationary Earth orbit (GEO) using a Lockheed launch vehicle (LLV3) with three Castors and a large shroud. The current design uses liquid hydrogen as the propellant and employs two inflatable 16 x 24 feet eliptical off-axis parabolic solar collectors to focus sunlight onto a tungsten/rhenium windowless black body type absorber. The concentration factor on this design is projected to be approximately 1800:1 for the primary collector and 2.42:1 for the secondary collector for an overall concentration factor of nearly 4400:1. The engine, which is about twice as efficient as the best currently available chemical engines, produces two pounds of thrust with a specific impulse (Isp) of 860 sec. Transfer times to GEO are projected to be on the order of one month. The launch and deployed configurations of the solar thermal upper stage (STUS) are depicted.

  19. Lunar Module Wiring Design Considerations and Failure Modes

    Interbartolo, Michael


    This slide presentation reviews the considerations for the design of wiring for the Lunar Module. Included are a review of the choice of conductors and insulations, the wire splicing (i.e., crimping, and soldering), the wire connectors, and the fabrication of the wire harnesses. The problems in fabrication include the wires being the wrong length, the damage due to the sharp edges, the requried use of temproary protective covers and inadequate training. The problems in the wire harness installation include damge from sharp eges, work on adjacent harnesses, connector damage, and breaking wires. Engineering suggestions from the Apollo-era in reference to the conductors that are reviewed include: the use of plated conductors, and the use of alloys for stronger wiring. In refernce to insulation, the suggestions from Apollo era include the use of polymer tape-wrap wire insulation due to the light weight, however, other types of modern insulation might be more cost-effective. In reference to wire splices and terminal boards the suggestions from the Apollo Era include the use of crimp splices as superior to solder splices, joining multiple wire to a common point using modular plug-ins might be more reliable, but are heavier than crimp splicing. For connectors, the lessons from the Apollo era indicate that a rear environmental seal that does not require additional potting is preferred, and pins should be crimped or welded to the incoming wires and be removable from the rear of the connector.

  20. Energy-harvesting laser phosphor display and its design considerations

    Fujieda, Ichiro; Itaya, Shunsuke; Ohta, Masamichi; Hirai, Yuuki; Kohmoto, Takamasa


    One can convert a luminescent solar concentrator to a display by projecting intensity-modulated light on it. We fabricated a 95 mm×95 mm×10 mm screen by sandwiching a thin coumarin 6 layer with two acrylic plates. We removed the light source in a commercial projector and fed a blue laser beam into its optics. It displayed monochrome images on the screen clearly. A photodiode covered a 10 mm×10 mm region on the edge surface of the screen. As we pulsed the laser, the photodiode output varied synchronously. Its output indicates that a fully covered version would harvest up to 71% of the incoming laser power. However, a ghost image was noticeable when we displayed a high-contrast still image. We address two aspects in design considerations. First, tiling small modules will reduce the thickness of a large-area projection system and alleviate its self-absorption loss. For seamless tiling, we can attach output couplers to the surface of the transparent plate and extract photoluminescence (PL) photons in each module. Second, the origin of the ghost image is the PL photons reflected at the plate-air interface inside the screen. Thinning the transparent plate facing the projector will eliminate such an optical cross talk.

  1. Completion Design Considerations for a Horizontal Enhanced Geothermal System

    Olson, Jeffrey; Eustes, Alfred; Fleckenstein, William; Eker, Erdinc; Baker, Reed; Augustine, Chad


    The petroleum industry has had considerable success in recent decades in developing unconventional shale plays using horizontal drilling and multi-zonal isolation and stimulation techniques to fracture tight formations to enable the commercial production of oil and gas. Similar well completions could be used in Enhanced Geothermal Systems (EGS) to create multiple fractures from horizontal wells. This study assesses whether well completion techniques used in the unconventional shale industry to create multi-stage fractures can be applied to an enhanced geothermal system, with a focus on the completion of the EGS injection well. This study assumes an Enhanced Geothermal System (EGS) consisting of a central horizontal injection well flanked on each side by horizontal production wells, connected to the injection well by multiple fractures. The focus is on the design and completion of the horizontal well. For the purpose of developing design criteria, a reservoir temperature of 200 degrees C (392 degrees F) and an injection well flow rate of 87,000 barrels per day (160 kg/s), corresponding to production well flow rates of 43,500 barrels per day (80 kg/s) is assumed. The analysis found that 9-5/8 inches 53.5 pounds per foot (ppf) P110 casing string with premium connections meets all design criteria for the horizontal section of injection well. A P110 grade is fairly common and is often used in horizontal sections of shale development wells in petroleum operations. Next, several zonal isolation systems commonly used in the shale gas industry were evaluated. Three techniques were evaluated -- a 'plug and perf' design, a 'sand and perf' design, and a 'packer and port' design. A plug and perf system utilizes a cemented casing throughout the length of the injector wellbore. The sand and perf system is identical to the plug and perf system, but replaces packers with sand placed in the casing after stimulation to screen out the stimulated

  2. Primary Design of DTL for CPHS

    Zheng, Shu-xin; Wei, Jie; Zhang, Huayi; Billen, James; Young, Lloyd; Li, Jinhai; Zhang, Dong-sheng; Li, Jian; Stovall, James; Zhao, Yaliang


    The Compact Pulsed Hadron Source (CPHS) has launched at Tsinghua University to develop a neutron source based on a 13-MeV, 50-mA proton linac, consisting of an ECR ion source, LEBT, RFQ, and DTL. The primary design of the DTL for the CPHS is presented in this paper, which includes the dynamics calculation, RF field optimization, and error analysis. This DTL accelerates a 50-mA proton beam from 3 MeV to 13 MeV with 1.2 MW of RF power. The DTL directly follows the RFQ with no Medium-Energy Beam-Transport line (MEBT). Transverse focusing is provided by PMQs housed in the drift tubes. The focusing lattice is designed to continue the transverse phase advance of the RFQ to preserve current independence while avoiding mismatches and parametric resonances

  3. Designing the primary mirror support for the E-ELT

    Nijenhuis, Jan; Heijmans, Jeroen; den Breeje, Remco; Hazelebach, René; de Vreugd, Jan; Crowcombe, Will; Naron, Daniel; Fritz, Erik; Borghi, Guiseppe; Navarro, Ramon; Sillari, Luca; Sambenedetto, Enrico; Eder, Josef; Kamphues, Fred


    Described is the M1 segment support, as designed by TNO in the period 2015-2016. The design has significantly changed and improved compared to the earlier designs. During the period 2009-2010 prototypes for the primary mirror support of the E-ELT have been developed. These have been extensively tested by ESO. Design improvement were found to be necessary, especially in the field of manufacturability and maintainability. Furthermore, the technical performance had to improve in specific areas as well. This has evolved into a new specifications which have resulted in a new design for the segment support structure. The design rules that have led to the prototype design have been maintained but the implementation has been much improved. Also considerable improvement has been obtained with respect to the dynamic behavior. Accessibility and visibility on all parts and subsystems has changed such that everything is now clearly visible. Despite the increased performance no mass increase has been recorded meaning that more efficient use has been made of the material. The active means to influence the segment shape by use of the warping harness has been completely redesigned. A very important quality that has been achieved is simplicity. Hence a minimum amount of components is used. Reliability and safety are other aspects that have been greatly improved compared to the prototypes. The design for the M1 segment support provides a solution that not only performs to specification but one that can be operated in a telescope environment, all 798 of them.

  4. Passive wick fluxmeters: Design considerations and field applications

    Gee, G. W.; Newman, B. D.; Green, S. R.; Meissner, R.; Rupp, H.; Zhang, Z. F.; Keller, J. M.; Waugh, W. J.; van der Velde, M.; Salazar, J.


    Optimization of water use in agriculture and quantification of percolation from landfills and watersheds require reliable estimates of vadose zone water fluxes. Current technology is limited primarily to lysimeters, which directly measure water flux but are expensive and may in some way disrupt flow, causing errors in the measured drainage. We report on design considerations and field tests of an alternative approach, passive wick fluxmeters, which use a control tube to minimize convergent or divergent flow. Design calculations with a quasi-three-dimensional model illustrate how convergence and divergence can be minimized for a range of soil and climatic conditions under steady state and transient fluxes using control tubes of varying heights. There exists a critical recharge rate for a given wick length, where the fluxmeter collection efficiency is 100% regardless of the height of the control tube. Otherwise, convergent or divergent flow will occur, especially when the control tube height is small. While divergence is eliminated in coarse soils using control tubes, it is reduced but not eliminated in finer soils, particularly for fluxes soils ranging from nonvegetated semiarid settings in the United States to grasslands in Germany and rain-fed crops in New Zealand and the South Pacific. Where side-by-side comparisons of drainage were made between passive wick fluxmeters and conventional lysimeters in the United States and Germany, agreement was very good. In semiarid settings, drainage was found to depend upon precipitation distribution, surface soil, topographic relief, and the type and amount of vegetation. In Washington State, United States, soil texture dominated all factors controlling drainage from test landfill covers. As expected, drainage was greatest (>60% annual precipitation) from gravel surfaces and least (no drainage) from silt loam soils. In Oregon and New Mexico, United States, and in New Zealand, drainage showed substantial spatial variability


    Marshall, Douglas W.


    High Temperature Gas Cooled Reactors (HTGRs) are fueled with tristructural isotropic (TRISO) coated nuclear fuel particles embedded in a carbon-graphite fuel body. TRISO coatings consist of four layers of pyrolytic carbon and silicon carbide that are deposited on uranium ceramic fuel kernels (350µm – 500µm diameters) in a concatenated series of batch depositions. Each layer has dedicated functions such that the finished fuel particle has its own integral containment to minimize and control the release of fission products into the fuel body and reactor core. The TRISO coatings are the primary containment structure in the HTGR reactor and must have very high uniformity and integrity. To ensure high quality TRISO coatings, the four layers are deposited by chemical vapor deposition (CVD) using high purity precursors and are applied in a concatenated succession of batch operations before the finished product is unloaded from the coating furnace. These depositions take place at temperatures ranging from 1230°C to 1550°C and use three different gas compositions, while the fuel particle diameters double, their density drops from 11.1 g/cm3 to 3.0 g/cm3, and the bed volume increases more than 8-fold. All this is accomplished without the aid of sight ports or internal instrumentation that could cause chemical contamination within the layers or mechanical damage to thin layers in the early stages of each layer deposition. The converging section of the furnace retort was specifically designed to prevent bed stagnation that would lead to unacceptably high defect fractions and facilitate bed circulation to avoid large variability in coating layer dimensions and properties. The gas injection nozzle was designed to protect precursor gases from becoming overheated prior to injection, to induce bed spouting and preclude bed stagnation in the bottom of the retort. Furthermore, the retort and injection nozzle designs minimize buildup of pyrocarbon and silicon carbide on the

  6. Feedback Control Systems Loop Shaping Design with Practical Considerations

    Kopsakis, George


    This paper describes loop shaping control design in feedback control systems, primarily from a practical stand point that considers design specifications. Classical feedback control design theory, for linear systems where the plant transfer function is known, has been around for a long time. But it s still a challenge of how to translate the theory into practical and methodical design techniques that simultaneously satisfy a variety of performance requirements such as transient response, stability, and disturbance attenuation while taking into account the capabilities of the plant and its actuation system. This paper briefly addresses some relevant theory, first in layman s terms, so that it becomes easily understood and then it embarks into a practical and systematic design approach incorporating loop shaping design coupled with lead-lag control compensation design. The emphasis is in generating simple but rather powerful design techniques that will allow even designers with a layman s knowledge in controls to develop effective feedback control designs.

  7. 77 FR 74196 - Draft Guidance for Industry on Safety Considerations for Product Design To Minimize Medication...


    ... Product Design To Minimize Medication Errors; Availability AGENCY: Food and Drug Administration, HHS... guidance for industry entitled ``Safety Considerations for Product Design to Minimize Medication Errors... using a systems approach to minimize medication errors relating to product design. The draft...

  8. Design considerations for lunar base photovoltaic power systems

    Hickman, J. Mark; Curtis, Henry B.; Landis, Geoffrey A.


    A survey was made of factors that may affect the design of photovoltaic arrays for a lunar base. These factors, which include the lunar environment and system design criteria, are examined. A photovoltaic power system design with a triangular array geometry is discussed and compared to a nuclear reactor power systems and a power system utilizing both nuclear and solar power sources.

  9. Design considerations for HFQ® hot stamped aluminium structural panels

    Foster Alistair


    Full Text Available HFQ is a deep drawing process for alloyed aluminium sheet that can be used to produce complex-stamped forms while maintaining the high-strength of 6xxx and 7xxx alloys. By adopting a strategy to design for HFQ at the platform level, designers can reduce part count (thereby reducing cost and weight, reduce gauge (thereby reducing weight, and improve part packaging. Two simple design examples are given to assist designers in evolving traditionally formed panel designs to HFQ formed solutions. Example features are used to illustrate the effect of geometry, thickness and strength on the final structural component.

  10. A methodology for integrating sustainability considerations into process design

    Azapagic, A.; Millington, A.; Collett, A


    Designing more sustainable processes is one of the key challenges for sustainable development of the chemical industry. This is by no means a trivial task as it requires translating the theoretical principles of sustainable development into design practice. At present, there is no general methodology to guide sustainable process design and almost no practical experience. In an attempt to contribute to this emerging area, this paper proposes a new methodology for integrating sustainability con...

  11. Design considerations for beamwaveguide in the NASA Deep Space Network

    Veruttipong, Thavath; Withington, James R.; Galindo-Israel, Victor; Imbraile, William A.; Bathker, Dan A.


    A generalized solution is found for retrofitting a large dual-shaped reflector antenna for a beamwaveguide. The design is termed as a bypass beamwaveguide. Both highpass design feed imaging and bandpass design feed imaging are considered. Each design was studied using geometrical optics, Gaussian wave analysis, and both low-frequency and high-frequency diffraction analysis. An important extension of the Mizusawa-Kitsuregawa criteria was discovered (Zusama and Kitsuregawa, 1973). The principle revealed shows how a two-reflector cell, although in itself distorting, may be combined with a second cell which compensates for the first and delivers an output beam which is a good image of the input beam.

  12. Biomechanical design considerations for transradial prosthetic interface: A review.

    Sang, Yuanjun; Li, Xiang; Luo, Yun


    Traditional function and comfort assessment of transradial prostheses pay scant attention to prosthetic interface. With better understanding of the biomechanics of prosthetic interface comes better efficiency and safety for interface design; in this way, amputees are more likely to accept prosthetic usage. This review attempts to provide design and selection criteria of transradial interface for prosthetists and clinicians. Various transradial socket types in the literature were chronologically reviewed. Biomechanical discussion of transradial prosthetic interface design from an engineering point of view was also done. Suspension control, range of motion, stability, as well as comfort and safety of socket designs have been considered in varying degrees in the literature. The human-machine interface design should change from traditional "socket design" to new "interface design." From anatomy and physiology to biomechanics of the transradial residual limb, the force and motion transfer, together with comfort and safety, are the two main aspects in prosthetic interface design. Load distribution and transmission should mainly rely on achieving additional skeletal control through targeted soft tissue relief. Biomechanics of the residual limb soft tissues should be studied to find the relationship between mechanical properties and the comfort and safety of soft tissues. © IMechE 2016.

  13. Feed-in Tariffs: Good Practices and Design Considerations

    Cox, Sadie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Esterly, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States)


    In recent years, feed-in tariff (FIT) activity has focused primarily on revisions to current policies, underscoring the need for stable and predictable, yet flexible, policy environments. This policy brief provides a primer on key FIT design elements, lessons from country experience, and support resources to enable more detailed and country-specific FIT policy design.

  14. Renewable Electricity Standards: Good Practices and Design Considerations

    Cox, Sadie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Esterly, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States)


    In widespread use globally, renewable electricity standards (RES) are one of the most widely adopted renewable energy policies and a critical regulatory vehicle to accelerate renewable energy deployment. This policy brief provides an introduction to key RES design elements, lessons from country experience, and support resources to enable more detailed and country-specific RES policy design.

  15. Design and control considerations for industrial and space manipulators

    Whitney, D. E.; Book, W. J.; Lynch, P. M.


    This paper is a progress report summarizing theoretical and practical results concerning integration of design and control aspects of manipulator arms for industrial or space applications. The relationships between task specifications, gross motions, fine motions, actuator type and location, size and strength of structural members, control servos and strategies, and overall design evaluation are briefly discussed, with some technical examples.

  16. Design Considerations of Permanent Magnet Transverse Flux Machines

    Lu, Kaiyuan; Rasmussen, Peter Omand; Ritchie, Ewen


    Permanent magnet transverse flux machine (PMTFM) is well known for its high torque density and is interested in various direct-drive applications. Due to its complicated 3-D flux components, design and design optimization of a PMTFM is more difficult and time consuming than for radial flux...

  17. Design and control considerations for industrial and space manipulators

    Whitney, D. E.; Book, W. J.; Lynch, P. M.


    This paper is a progress report summarizing theoretical and practical results concerning integration of design and control aspects of manipulator arms for industrial or space applications. The relationships between task specifications, gross motions, fine motions, actuator type and location, size and strength of structural members, control servos and strategies, and overall design evaluation are briefly discussed, with some technical examples.

  18. Design considerations for an archimedean slot spiral antenna

    Nurnberger, Michael W.; Volakis, John L.


    The design goal is to develop a 118-157 MHz, vertically polarized, low-profile (or conformal) antenna as a replacement for VHF AM blade antennas on aircraft. This design is to be arrived at by scaling the dimensions of an antenna designed for a center frequency of 1.1 GHz. The design prior to scaling may have the following maximum dimensions: diameter less than 3.70 in. and thickness less than 0.50 in. Although a four-arm spiral design was originally suggested, a two-arm spiral may also be used, as both mode-1 and mode-2 (sum and difference) radiation patterns aren't required. While a four-arm spiral can easily be designed should both sum and difference patterns be required, the two-arm design will provide the required sum pattern and simplify the design problem somewhat: only one feed is required, and the feed area geometry is more straightforward. Polarization requirements dictate that a slot spiral be used, as opposed to a wire spiral. Two similar radiating structures were considered. The first is the standard archimedean spiral antenna. The second is a hollow archimedean spiral antenna, essentially a standard archimedean spiral with the inner portion removed.

  19. Design considerations in Li/SOCl{sub 2} battery technology

    Cieslak, W.R.


    Li/SOCl{sub 2} battery technology is attractive by virtue of its high energy density, low self-discharge rate, and ability to to perform well at a wide variety of discharge rates. However, some of these same attributes also make Li/SOCl{sub 2} cells capable of hightly exothermic events when handled under abnormal conditions. We manage the energy safely and optimize the performance by tailoring the design to the application. We have developed three different ``D`` size cells that target low, moderate, and high rate applications. Each design provides safe and efficient performance, although, in progressing from low to high rate capability, the likelihood of venting under abuse conditions increses. We incorporate a vent mechanism in all designs as the ultimate protection from severe abuse. The details of our battery designs and the benefits of application-specific design are discussed.

  20. Practical considerations in the pharmacological treatment of postherpetic neuralgia for the primary care provider

    Massengill JS


    Full Text Available Jamie S Massengill,1 John L Kittredge2 1JSM Medical, Edmond, OK, USA; 2Michiana Spine, Sports and Occupational Rehab, PC, Mishawaka, IN, USA Abstract: An estimated one million individuals in the US are diagnosed with herpes zoster (HZ; shingles each year. Approximately 20% of these patients will develop postherpetic neuralgia (PHN, a complex HZ complication characterized by neuropathic pain isolated to the dermatome that was affected by the HZ virus. PHN is debilitating, altering physical function and quality of life, and commonly affects vulnerable populations, including the elderly and the immunocompromised. Despite the availability of an immunization for HZ prevention and several approved HZ treatments, the incidence of PHN is increasing. Furthermore, management of the neuropathic pain associated with PHN is often suboptimal, and the use of available therapeutics may be complicated by adverse effects and complex, burdensome treatment regimens, as well as by patients' comorbidities and polypharmacy, which may lead to drug–drug interactions. Informed and comprehensive assessments of currently available pharmacological treatment options to achieve effective pain control in the primary care setting are needed. In this article, we discuss the situation in clinical practice, review currently recommended prevention and treatment options for PHN, and outline practical considerations for the management of this neuropathic pain syndrome, with a focus on optimal, individual-based treatment plans for use in the primary care setting. Keywords: herpes zoster, postherpetic neuralgia, primary care, clinical practice, pharmacological treatment, practical guidelines

  1. Anthropometric evaluation for primary school furniture design.

    Chung, Joanne W Y; Wong, Thomas K S


    Musculoskeletal symptoms are one of the top ten health problems among schoolchildren in Hong Kong. Whether or not these symptoms are related to school furniture has yet to be determined and published data on furniture size are lacking. The purpose of the study was to determine whether the design of furniture in schools is appropriate for children's anthropometry. A total of 214 volunteer subjects were recruited. This constituted 90% of the total number of primary 5 and 6 students in the studied school (i.e. those aged 10 and 13 years). The data collected included demographic information, data on perceived health and posture and body and furniture measurements. The girls' BMI was lower than that of the boys. The girls had longer lower limbs and wider hip breadth measurements in the standing position. This was similar in the sitting position. Almost none of the subjects had a chair with an appropriate seat height. Seat depth was found appropriate for large groups of students whether or not a large or small chair was used. Recommendations on the sizes of chairs and desks for boys and girls are discussed.

  2. Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations.

    Dworkin, Robert H; Turk, Dennis C; Peirce-Sandner, Sarah; Baron, Ralf; Bellamy, Nicholas; Burke, Laurie B; Chappell, Amy; Chartier, Kevin; Cleeland, Charles S; Costello, Ann; Cowan, Penney; Dimitrova, Rozalina; Ellenberg, Susan; Farrar, John T; French, Jacqueline A; Gilron, Ian; Hertz, Sharon; Jadad, Alejandro R; Jay, Gary W; Kalliomäki, Jarkko; Katz, Nathaniel P; Kerns, Robert D; Manning, Donald C; McDermott, Michael P; McGrath, Patrick J; Narayana, Arvind; Porter, Linda; Quessy, Steve; Rappaport, Bob A; Rauschkolb, Christine; Reeve, Bryce B; Rhodes, Thomas; Sampaio, Cristina; Simpson, David M; Stauffer, Joseph W; Stucki, Gerold; Tobias, Jeffrey; White, Richard E; Witter, James


    There has been an increase in the number of chronic pain clinical trials in which the treatments being evaluated did not differ significantly from placebo in the primary efficacy analyses despite previous research suggesting that efficacy could be expected. These findings could reflect a true lack of efficacy or methodological and other aspects of these trials that compromise the demonstration of efficacy. There is substantial variability among chronic pain clinical trials with respect to important research design considerations, and identifying and addressing any methodological weaknesses would enhance the likelihood of demonstrating the analgesic effects of new interventions. An IMMPACT consensus meeting was therefore convened to identify the critical research design considerations for confirmatory chronic pain trials and to make recommendations for their conduct. We present recommendations for the major components of confirmatory chronic pain clinical trials, including participant selection, trial phases and duration, treatment groups and dosing regimens, and types of trials. Increased attention to and research on the methodological aspects of confirmatory chronic pain clinical trials has the potential to enhance their assay sensitivity and ultimately provide more meaningful evaluations of treatments for chronic pain.

  3. On-chip antenna: Practical design and characterization considerations

    Shamim, Atif


    This paper highlights the challenges of an emergent field, namely, on-chip antenna design. Consistent with the RF System-on-Chip (SoC) concept, co-design strategy for circuits and on-chip antennas is described. A number of design and layout issues, arising from the highly integrated nature of this kind of systems, are discussed. The characterization difficulties related to on-chip antennas radiation properties are also highlighted. Finally, a novel on-wafer test fixture is proposed to measure the gain and radiation pattern of the on-chip antennas in the anechoic chamber.

  4. Design Considerations of a Solid State Thermal Energy Storage

    Janbozorgi, Mohammad; Houssainy, Sammy; Thacker, Ariana; Ip, Peggy; Ismail, Walid; Kavehpour, Pirouz


    With the growing governmental restrictions on carbon emission, renewable energies are becoming more prevalent. A reliable use of a renewable source however requires a built-in storage to overcome the inherent intermittent nature of the available energy. Thermal design of a solid state energy storage has been investigated for optimal performance. The impact of flow regime, laminar vs. turbulent, on the design and sizing of the system is also studied. The implications of low thermal conductivity of the storage material are discussed and a design that maximizes the round trip efficiency is presented. This study was supported by Award No. EPC-14-027 Granted by California Energy Commission (CEC).

  5. Practical considerations for adaptive trial design and implementation

    Pinheiro, José; Kuznetsova, Olga


    This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers.  In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low.  One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, t...

  6. Geothermal FIT Design: International Experience and U.S. Considerations

    Rickerson, W.; Gifford, J.; Grace, R.; Cory, K.


    Developing power plants is a risky endeavor, whether conventional or renewable generation. Feed-in tariff (FIT) policies can be designed to address some of these risks, and their design can be tailored to geothermal electric plant development. Geothermal projects face risks similar to other generation project development, including finding buyers for power, ensuring adequate transmission capacity, competing to supply electricity and/or renewable energy certificates (RECs), securing reliable revenue streams, navigating the legal issues related to project development, and reacting to changes in existing regulations or incentives. Although FITs have not been created specifically for geothermal in the United States to date, a variety of FIT design options could reduce geothermal power plant development risks and are explored. This analysis focuses on the design of FIT incentive policies for geothermal electric projects and how FITs can be used to reduce risks (excluding drilling unproductive exploratory wells).

  7. Multiaxial and thermomechanical fatigue considerations in damage tolerant design

    Leese, G. E.; Bill, R. C.


    In considering damage tolerant design concepts for gas turbine hot section components, several challenging concerns arise: Complex multiaxial loading situations are encountered; Thermomechanical fatigue loading involving very wide temperature ranges is imposed on components; Some hot section materials are extremely anisotropic; and coatings and environmental interactions play an important role in crack propagation. The effects of multiaxiality and thermomechanical fatigue are considered from the standpoint of their impact on damage tolerant design concepts. Recently obtained research results as well as results from the open literature are examined and their implications for damage tolerant design are discussed. Three important needs required to advance analytical capabilities in support of damage tolerant design become readily apparent: (1) a theoretical basis to account for the effect of nonproportional loading (mechanical and mechanical/thermal); (2) the development of practical crack growth parameters that are applicable to thermomechanical fatigue situations; and (3) the development of crack growth models that address multiple crack failures.

  8. Ultra-mobile rugged computing platform design considerations

    Garcia, Ray; Wright-Johnson, Mark; Daniels, Reginald


    State of the art mobile computing is designed to withstand variable rugged environments. Specific platforms including mobile phones, GPS devices, tablets, Netbooks and laptops that are used by the general public and increasingly by dismounted military users.

  9. Propagation considerations in the American Mobile Satellite system design

    Kittiver, Charles; Sigler, Charles E., Jr.


    An overview of the American Mobile Satellite Corporation (AMSC) mobile satellite services (MSS) system with special emphasis given to the propagation issues that were considered in the design is presented. The aspects of the voice codec design that effect system performance in a shadowed environment are discussed. The strategies for overcoming Ku-Band rain fades in the uplink and downlink paths of the gateway station are presented. A land mobile propagation study that has both measurement and simulation activities is described.

  10. Optimum municipal wastewater treatment plant design with consideration of uncertainty

    ZENG Guang-ming; LIN Yu-peng; QIN Xiao-sheng; HUANG Guo-he; LI Jian-bing; JIANG Ru


    A newly developed model for the optimum municipal wastewater treatment plant (MWTP) design is presented. Through introducing the interval variables, the model attempts to consider the effects of uncertainties caused by the fluctuation of the wastewater quality and quantity during the design of MWTP. The model solution procedure is illustrated in detail, and a numerical example is given to verify the feasibility and advantage of the model. Furthermore, the possibility of the model application is briefly outlined.



    Some important factors for designing a series hybrid active power filter (SHAPF) are presented in this paper for the case when the load is varied in a wide range and/or the source voltage is seriously distorted. Special design of passive filters, adaptive control of parameter and multi variant control are discussed in detail. The filter is stable, has good performance, and causes small capacitive reactive current. The simulation and experimental results accorded with the theoretical analysis results.

  12. Design Considerations for an Underactuated Robotic Finger Mechanism

    YAO Shuangji; CECCARELLI Marco; ZHAN Qiang; ARBONE Giuseppe; LU Zhen


    A design approach is presented in this paper for underactuation in robotic finger mechanisms. The characters of underactuated finger mechanisms are introduced as based on linkage and spring systems. The feature of self-adaptive enveloping grasp by underactuated finger mechanisms is discussed with feasible in grasping unknown objects. The design problem of robotic fingers is analyzed by looking at many aspects for an optimal functionality. Design problems and requirements for underactuated mechanisms are formulated as related to human-like robotic fingers. In particular, characteristics of finger mechanisms are analyzed and optimality criteria are summarized with the aim to formulate a general design algorithm. A general multi-objective optimization design approach is applied as based on a suitable optimization problem by using suitable expressions of optimality criteria. An example is illustrated as an improvement of finger mechanism in Laboratory of Robotics and Mechatronics (LARM) Hand. Results of design outputs and grasp simulations are reported with the aim to show the practical feasibility of the proposed concepts and computations.

  13. Initial MPTS study results: Design considerations and issues

    Maynard, O. E.


    One of the key issues identified during investigations of microwave power transmission systems from 1965 to 1976 was the need to assure that the billions of diodes on ground-based rectennas are sufficiently reliable to support long life times of approximately 30 years. Major systems studies conducted focused on waveguides; radio frequency interference and biological considerations; the relationship between performance, weight, and cost; risk assessment; crossed field directional amplifier noise; a 48 kW klystron; effects of the environment on propagation and phase control; rectenna technology; a rationale for the ground power density region; alternate technologies for orbital assembly; ionospheric effects and phase control; and reception conversion (rf to dc collector/converter).

  14. Some design considerations for ceramic components in heat engine applications

    Gyekenyesi, John P.


    The design methodology for brittle material structures which is being developed and used at the Lewis Research Center for sizing ceramic components in heat engine applications is reviewed. Theoretical aspects of designing with structural ceramics are discussed, and a general purpose reliability program for predicting fast fracture response due to volume distributed flaws is described. Statistical treatment of brittle behavior, based on the Weibull model, is reviewed and its advantages, as well as drawbacks, are listed. A mechanistic statistical fracture theory, proposed by Batdorf to overcome the Weibull model limitations and based on Griffith fracture mechanics, is summarized. Failure probability predictions are made for rotating annular Si3N4 disks using various fracture models, and the results are compared to actual failure data. The application of these design methods to Government funded ceramics engine demonstration programs is surveyed. The uncertainty in observed component performance emphasizes the need for proof testing and improved nondestructive evaluation to guarantee adequate structural integrity.

  15. Magnet Design Considerations for Fusion Nuclear Science Facility

    Zhai, Y. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Kessel, C. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); El-Guebaly, L. [Univ. of Wisconsin, Madison, WI (United States) Fusion Technology Institute; Titus, P. [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States)


    The Fusion Nuclear Science Facility (FNSF) is a nuclear confinement facility that provides a fusion environment with components of the reactor integrated together to bridge the technical gaps of burning plasma and nuclear science between the International Thermonuclear Experimental Reactor (ITER) and the demonstration power plant (DEMO). Compared with ITER, the FNSF is smaller in size but generates much higher magnetic field, i.e., 30 times higher neutron fluence with three orders of magnitude longer plasma operation at higher operating temperatures for structures surrounding the plasma. Input parameters to the magnet design from system code analysis include magnetic field of 7.5 T at the plasma center with a plasma major radius of 4.8 m and a minor radius of 1.2 m and a peak field of 15.5 T on the toroidal field (TF) coils for the FNSF. Both low-temperature superconductors (LTS) and high-temperature superconductors (HTS) are considered for the FNSF magnet design based on the state-of-the-art fusion magnet technology. The higher magnetic field can be achieved by using the high-performance ternary restacked-rod process Nb3Sn strands for TF magnets. The circular cable-in-conduit conductor (CICC) design similar to ITER magnets and a high-aspect-ratio rectangular CICC design are evaluated for FNSF magnets, but low-activation-jacket materials may need to be selected. The conductor design concept and TF coil winding pack composition and dimension based on the horizontal maintenance schemes are discussed. Neutron radiation limits for the LTS and HTS superconductors and electrical insulation materials are also reviewed based on the available materials previously tested. The material radiation limits for FNSF magnets are defined as part of the conceptual design studies for FNSF magnets.

  16. Considerations on Seismic Design of Installations using Natural Gas Fuel

    Adriana Tokar


    Full Text Available The paper presents issues relating to existing standards underlying seismic design restrictions for non-structural components (NSC related to constructions. Are presented measures that can be implemented to maintain a high level of safety in case of earthquake, natural gas plants, which due to the flammability of fuel, carry some risk of fire or explosion. The purpose of this paper is to highlight the need for seismic design of facilities using natural gas fuel for new buildings but also to review the existing installations in buildings by taking mandatory measures.

  17. Mems Electromagnetic Micro Relays Overview and Design Considerations

    Zuraini Dahari, Thurai Vinay and Dinesh Sood


    Full Text Available Miniature electromagnetic relay matrices capable of switching currents up to one ampere range are  widely used in commercial applications such as instrumentation and telecommunication. Traditionally these devices have been fabricated from a number of discrete components, however in recent years the emergence of Micro Electro Mechanical System (MEMS technology has opened up the possibility for batch fabrication of microrelays at much reduced unit cost. While several electromagnetic microrelay designs have been successfully developed and commercialized for use as individual units, development work on electromagnetic microrelay matrices where individual relays can be selectively switched on and off have been fewer and less successful. Due to inherent limitations of the micromachining processes, significant dimensional and material property variations occur among individual relays in a matrix. These variations severely limit the tolerance window and hence the reliability of operation of the device. After reviewing existing designs of electromagnetic microrelays, a set of desirable design features that would make the electromagnetic microrelay more robust are identified.  A novel design incorporating these features is proposed and preliminary results of ANSYS1 simulation studies are presented.Keywords: MEMS, microrelay and electromagnetic

  18. Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints

    Tompson, M.K.; Moroni, G.; Vaneker, Thomas H.J.; Fadel, G.; Campbell, I.; Gibson, I.; Bernard, A.; Schulz, J.; Graf, P.; Ahuja, B.; Martina, F.


    The past few decades have seen substantial growth in Additive Manufacturing (AM) technologies. However, this growth has mainly been process-driven. The evolution of engineering design to take advantage of the possibilities afforded by AM and to manage the constraints associated with the technology h

  19. Acoustical Considerations in Planning and Design of Library Facilities.

    Wrightson, Denelle; Wrightson, John M.


    Discusses acoustical demands in public libraries to consider during the design and construction process of new or renovated library space. Topics include intrusive noises; overly reverberant spaces; lack of speech privacy; sound transmission class; noise criteria; reverberation time and noise reduction coefficient; space planning; sound systems;…

  20. Additive Manufacturing Design Considerations for Liquid Engine Components

    Whitten, Dave; Hissam, Andy; Baker, Kevin; Rice, Darron


    The Marshall Space Flight Center's Propulsion Systems Department has gained significant experience in the last year designing, building, and testing liquid engine components using additive manufacturing. The department has developed valve, duct, turbo-machinery, and combustion device components using this technology. Many valuable lessons were learned during this process. These lessons will be the focus of this presentation. We will present criteria for selecting part candidates for additive manufacturing. Some part characteristics are 'tailor made' for this process. Selecting the right parts for the process is the first step to maximizing productivity gains. We will also present specific lessons we learned about feature geometry that can and cannot be produced using additive manufacturing machines. Most liquid engine components were made using a two-step process. The base part was made using additive manufacturing and then traditional machining processes were used to produce the final part. The presentation will describe design accommodations needed to make the base part and lessons we learned about which features could be built directly and which require the final machine process. Tolerance capabilities, surface finish, and material thickness allowances will also be covered. Additive Manufacturing can produce internal passages that cannot be made using traditional approaches. It can also eliminate a significant amount of manpower by reducing part count and leveraging model-based design and analysis techniques. Information will be shared about performance enhancements and design efficiencies we experienced for certain categories of engine parts.

  1. Safety Considerations in the Design of Riot-Control Grenades


    fuze design resulted in injuries to the user, because the user would not maintain the required pressure after removing the safety pin . The grenade...of the M25A2 grenade was the accidental functioning of the grenade with the safety pin intact. If the ferenade was dropped onto a hard surface

  2. Teachers' Considerations of Students' Thinking during Mathematics Lesson Design

    Amador, Julie M.


    Teachers' abilities to design mathematics lessons are related to their capability to mobilize resources to meeting intended learning goals based on their noticing. In this process, knowing how teachers consider Students' thinking is important for understanding how they are making decisions to promote student learning. While teaching, what teachers…

  3. Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints

    Tompson, M.K.; Moroni, G.; Vaneker, T.H.J.; Fadel, G.; Campbell, I.; Gibson, I.; Bernard, A.; Schulz, J.; Graf, P.; Ahuja, B.; Martina, F.


    The past few decades have seen substantial growth in Additive Manufacturing (AM) technologies. However, this growth has mainly been process-driven. The evolution of engineering design to take advantage of the possibilities afforded by AM and to manage the constraints associated with the technology h

  4. Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints

    Tompson, M.K.; Moroni, G.; Vaneker, Thomas H.J.; Fadel, G.; Campbell, I.; Gibson, I.; Bernard, A.; Schulz, J.; Graf, P.; Ahuja, B.; Martina, F.


    The past few decades have seen substantial growth in Additive Manufacturing (AM) technologies. However, this growth has mainly been process-driven. The evolution of engineering design to take advantage of the possibilities afforded by AM and to manage the constraints associated with the technology

  5. Flexible energy-storage devices: design consideration and recent progress.

    Wang, Xianfu; Lu, Xihong; Liu, Bin; Chen, Di; Tong, Yexiang; Shen, Guozhen


    Flexible energy-storage devices are attracting increasing attention as they show unique promising advantages, such as flexibility, shape diversity, light weight, and so on; these properties enable applications in portable, flexible, and even wearable electronic devices, including soft electronic products, roll-up displays, and wearable devices. Consequently, considerable effort has been made in recent years to fulfill the requirements of future flexible energy-storage devices, and much progress has been witnessed. This review describes the most recent advances in flexible energy-storage devices, including flexible lithium-ion batteries and flexible supercapacitors. The latest successful examples in flexible lithium-ion batteries and their technological innovations and challenges are reviewed first. This is followed by a detailed overview of the recent progress in flexible supercapacitors based on carbon materials and a number of composites and flexible micro-supercapacitors. Some of the latest achievements regarding interesting integrated energy-storage systems are also reviewed. Further research direction is also proposed to surpass existing technological bottle-necks and realize idealized flexible energy-storage devices. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Considerations in designing a centrifugal atomiser for metal powder production

    Zhao, Y.Y. [Department of Engineering, The University of Liverpool, Liverpool L69 3GH (United Kingdom)]. E-mail:


    In centrifugal atomisation for metal powder production, the key to the control of the particle sizes is the design of the atomiser. This paper studies the main issues concerned in designing a centrifugal atomiser and provides guidance on the selection of an electric motor, radius of atomiser, slope angle of atomiser wall and flow rate of cooling water. In the selection of the atomiser radius, the power and material constraints as well as the hydraulic jump radius need to be considered. A cup atomiser with a slope angle of 60-70{sup o} would result in small spray droplets and thus a fine powder. The water cooling system needs to be assessed by examining the heat flow in the solid metal layer and in the atomiser.

  7. Design Considerations for Stand-Alone Photovoltaic (PV Cell Applications

    Mehmet Cebeci


    Full Text Available Solar energy is one of the most important renewable energy sources. The photovoltaic (PV cell systems are used to convert solar energy into electricity. PV systems are divided into two as fixed systems and tracking systems. Fixed systems are mounted at a certain tilt with horizontal to make full use of sunlight. The tilt angle of PV arrays in a fixed system depends on the location and time. If this tilt angle is determined well, the amount of insolation and the energy that is generated increases. When a stand-alone PV cell system is being chosen, certain design operations should be implemented. The number of modules and batteries needed for any system should be calculated by means of the amount of load, insolation level, module characteristics, etc. The design of system is finalized according to the energy demand.

  8. Design Considerations for Human Rating of Liquid Rocket Engines

    Parkinson, Douglas


    I.Human-rating is specific to each engine; a. Context of program/project must be understood. b. Engine cannot be discussed independently from vehicle and mission. II. Utilize a logical combination of design, manufacturing, and test approaches a. Design 1) It is crucial to know the potential ways a system can fail, and how a failure can propagate; 2) Fault avoidance, fault tolerance, DFMR, caution and warning all have roles to play. b. Manufacturing and Assembly; 1) As-built vs. as-designed; 2) Review procedures for assembly and maintenance periodically; and 3) Keep personnel trained and certified. c. There is no substitute for test: 1) Analytical tools are constantly advancing, but still need test data for anchoring assumptions; 2) Demonstrate robustness and explore sensitivities; 3) Ideally, flight will be encompassed by ground test experience. III. Consistency and repeatability is key in production a. Maintain robust processes and procedures for inspection and quality control based upon development and qualification experience; b. Establish methods to "spot check" quality and consistency in parts: 1) Dedicated ground test engines; 2) Random components pulled from the line/lot to go through "enhanced" testing.

  9. Design and construction considerations for light steel structures

    G. P.J. de Vos


    Full Text Available Many alternative structural systems have recently been proposed in South Africa in an attempt to reduce costs of lightweight steel structures. Most of these comprise premanufactured components which are bolted together on site. Large industrial type structures are usually constructed with hot-rolled steel profiles, so that, apart from the architect, a structural engineer, manufacturer and contractor would be required. As an alternative to these existing practices, this article proposes design and construction techniques that may reduce the cost of the structure and at the same time create employment for emerging contractors. The proposed construction method consists of the welding together of lightweight profiles on site. For the structure the following is proposed: short pile  footings to provide partial fixidity to the structure, effective and lightweight compositions of cold-formed thin-walled profiles for structural elements, and stressed skin diaphragm design wherein the cladding, purlins and structural elements work together as one unit. Alternative portal frame configurations were analysed and designed to form larger structures, which indicates the versatility of the proposed construction concept. The article further illustrates that the utilization of the proposed construction method results in more economical structures and discusses applications of the principles on a number of real structures.

  10. Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations.

    Beier, Susann; Ormiston, John; Webster, Mark; Cater, John; Norris, Stuart; Medrano-Gracia, Pau; Young, Alistair; Cowan, Brett


    Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. The purpose of this study was to evaluate the impact of stent design on wall shear stress (WSS), time average WSS, and WSS gradient (WSSG), in idealized stent geometries using computational fluid dynamics. Strut spacing, thickness, luminal protrusion, and malapposition were systematically investigated and a comparison made between two commercially available stents (Omega and Biomatrix). Narrower strut spacing led to larger areas of adverse low WSS and high WSSG but these effects were mitigated when strut size was reduced, particularly for WSSG. Local hemodynamics worsened with luminal protrusion of the stent and with stent malapposition, adverse high WSS and WSSG were identified around peak flow and throughout the cardiac cycle respectively. For the Biomatrix stent, the adverse effect of thicker struts was mitigated by greater strut spacing, radial cell offset and flow-aligned struts. In conclusion, adverse hemodynamic effects of specific design features (such as strut size and narrow spacing) can be mitigated when combined with other hemodynamically beneficial design features but increased luminal protrusion can worsen the stent's hemodynamic profile significantly.

  11. Design and fabrication considerations of EUVL collectors for HVM

    Bianucci, G.; Cassol, G. L.; Kools, J.; Prea, M.; Salmaso, G.; Valsecchi, G.; Zocchi, F. E.; Bolshukhin, D.; Schürmann, M.; Schriever, G.; Mader, A.; Zink, P.


    The power roadmap for EUVL high volume manufacturing (HVM) exceeds the 200W EUV in-band power at intermediate focus, thus posing more demanding requirements on HVM sources, debris suppression systems and collectors. Starting from the lessons learned in the design and fabrication of the grazing incidence collectors for the Alpha EUVL scanners, Media Lario Technologies is developing HVM optical solutions that enable designed-in lifetime improvements, such as larger source-collector distances, optimized collection efficiency through larger collected solid angles, and customized EUV reflective layers. The optical design of an HVM collector is described together with the selection of the sacrificial ruthenium reflective layer. The water cooling layout of the collector is evolved from the integrated cooling technology developed at Alpha level into an innovative cooling layout that minimizes the thermal gradients across the mirrors and allows controlling the optical performance at the far-field plane. Finally, the evolution of the collector's manufacturing technologies for HVM is discussed. XTREME technologies and Philips Extreme UV support this work by integrating the collector in the complete source collector module (SoCoMo). At system level, each component of the SoCoMo is part of a development and improvement plan leading to a comprehensive system that will fulfill the 200+ W EUV in-band power at intermediate focus.

  12. Antenna Design Considerations for the Advanced Extravehicular Mobility Unit

    Bakula, Casey J.; Theofylaktos, Onoufrios


    NASA is designing an Advanced Extravehicular Mobility Unit (AEMU)to support future manned missions beyond low-Earth orbit (LEO). A key component of the AEMU is the communications assembly that allows for the wireless transfer of voice, video, and suit telemetry. The Extravehicular Mobility Unit (EMU) currently used on the International Space Station (ISS) contains a radio system with a single omni-directional resonant cavity antenna operating slightly above 400 MHz capable of transmitting and receiving data at a rate of about 125 kbps. Recent wireless communications architectures are calling for the inclusion of commercial wireless standards such as 802.11 that operate in higher frequency bands at much higher data rates. The current AEMU radio design supports a 400 MHz band for low-rate mission-critical data and a high-rate band based on commercial wireless local area network (WLAN) technology to support video, communication with non-extravehicular activity (EVA) assets such as wireless sensors and robotic assistants, and a redundant path for mission-critical EVA data. This paper recommends the replacement of the existing EMU antenna with a new antenna that maintains the performance characteristics of the current antenna but with lower weight and volume footprints. NASA has funded several firms to develop such an antenna over the past few years, and the most promising designs are variations on the basic patch antenna. This antenna technology at UHF is considered by the authors to be mature and ready for infusion into NASA AEMU technology development programs.

  13. Design considerations for an air core magnetic actuator

    Groom, Nelson J.


    Equations for the force produced by an air core electromagnet on a permanent magnet core as a function of the coil height, coil inner and outer radii, and core displacement are developed. The magnetization vector of the permanent magnet core is assumed to be aligned with the central axis of the electromagnet and the forces which are produced lie along the same axis. Variations in force due to changes in electromagnet parameters and core displacement are investigated and parameter plots which should be useful for coil design are presented.

  14. Design considerations for a low-noise CMOS image sensor

    González-Márquez, Ana; Charlet, Alexandre; Villegas, Alberto; Jiménez-Garrido, Francisco; Medeiro, Fernando; Domínguez-Castro, Rafael; Rodríguez-Vázquez, Ángel


    This paper reports a Low-Noise CMOS Image Sensor. Low-noise operation is achieved owing to the combination of a noise-enhanced pixel, the use of a two-step ADC architecture and the analysis, and the optimization thereof, of the noise contributed by the readout channel. The paper basically gathers the sensor architecture, the ADC converter architecture, the outcome of the noise analysis and some basic characterization data. The general low-noise design framework is discussed in the companion presentation.

  15. Considerations of Protein Subpockets in Fragment-Based Drug Design.

    Bartolowits, Matthew; Davisson, V Jo


    While the fragment-based drug design approach continues to gain importance, gaps in the tools and methods available in the identification and accurate utilization of protein subpockets have limited the scope. The importance of these features of small molecule-protein recognition is highlighted with several examples. A generalized solution for the identification of subpockets and corresponding chemical fragments remains elusive, but there are numerous advancements in methods that can be used in combination to address subpockets. Finally, additional examples of approaches that consider the relative importance of small-molecule co-dependence of protein conformations are highlighted to emphasize an increased significance of subpockets, especially at protein interfaces.

  16. Design and market considerations for axial flux superconducting electric machine design

    Ainslie, Mark D; Shaw, Robert; Dawson, Lewis; Winfield, Andy; Steketee, Marina; Stockley, Simon


    In this paper, the authors investigate a number of design and market considerations for an axial flux superconducting electric machine design that uses high temperature superconductors. This work was carried out as part of the University of Cambridge's Centre for Entrepreneurial Learning ETECH Project programme, designed to accelerate entrepreneurship and diffusion of innovations based on early stage and potentially disruptive technologies from the University. The axial flux machine design is assumed to utilise high temperature superconductors in both wire (stator winding) and bulk (rotor field) forms, to operate over a temperature range of 65-77 K, and to have a power output in the range from 10s of kW up to 1 MW (typical for axial flux machines), with approximately 2-3 T as the peak trapped field in the bulk superconductors. The authors firstly investigate the applicability of this type of machine as a generator in small- and medium-sized wind turbines, including the current and forecasted market and pricin...

  17. System-Level Design Considerations for Carbon Nanotube Electromechanical Resonators

    Christian Kauth


    Full Text Available Despite an evermore complete plethora of complex domain-specific semiempirical models, no succinct recipe for large-scale carbon nanotube electromechanical systems design has been formulated. To combine the benefits of these highly sensitive miniaturized mechanical sensors with the vast functionalities available in electronics, we identify a reduced key parameter set of carbon nanotube properties, nanoelectromechanical system design, and operation that steers the sensor’s performance towards system applications, based on open- and closed-loop topologies. Suspended single-walled carbon nanotubes are reviewed in terms of their electromechanical properties with the objective of evaluating orders of magnitude of the electrical actuation and detection mechanisms. Open-loop time-averaging and 1ω or 2ω mixing methods are completed by a new 4ω actuation and detection technique. A discussion on their extension to closed-loop topologies and system applications concludes the analysis, covering signal-to-noise ratio, and the capability to spectrally isolate the motional information from parasitical feedthrough by contemporary electronic read-out techniques.

  18. Mental and behavioral health environments: critical considerations for facility design.

    Shepley, Mardelle McCuskey; Watson, Angela; Pitts, Francis; Garrity, Anne; Spelman, Elizabeth; Kelkar, Janhawi; Fronsman, Andrea


    The purpose of the study was to identify features in the physical environment that are believed to positively impact staff and patients in psychiatric environments and use these features as the foundation for future research regarding the design of mental and behavioral health facilities. Pursuant to a broad literature review that produced an interview script, researchers conducted 19 interviews of psychiatric staff, facility administrators and architects. Interview data were analyzed using the highly structured qualitative data analysis process authored by Lincoln and Guba (1985). Seventeen topics were addressed ranging from the importance of a deinstitutionalized environment to social interaction and autonomy. The interviewees reinforced the controversy that exists around the implications of a deinstitutionalized environment, when the resulting setting diminishes patient and staff safety. Respondents tended to support open nurse stations vs. enclosed stations. Support for access to nature and the provision of an aesthetic environment was strong. Most interviewees asserted that private rooms were highly desirable because lower room density reduces the institutional character of a unit. However, a few interviewees adamantly opposed private rooms because they considered the increased supervision of one patient by another to be a deterrent to self-harm. The need to address smoking rooms in future research received the least support of all topics. Responses of interviews illustrate current opinion regarding best practice in the design of psychiatric facilities. The findings emphasize the need for more substantive research on appropriate physical environments in mental and behavioral health settings. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Design Considerations, Modeling and Analysis for the Multispectral Thermal Imager

    Borel, C.C.; Clodius, W.B.; Cooke, B.J.; Smith, B.W.; Weber, P.G.


    The design of remote sensing systems is driven by the need to provide cost-effective, substantive answers to questions posed by our customers. This is especially important for space-based systems, which tend to be expensive, and which generally cannot be changed after they are launched. We report here on the approach we employed in developing the desired attributes of a satellite mission, namely the Multispectral Thermal Imager. After an initial scoping study, we applied a procedure which we call: "End-to-end modeling and analysis (EEM)." We began with target attributes, translated to observable signatures and then propagated the signatures through the atmosphere to the sensor location. We modeled the sensor attributes to yield a simulated data stream, which was then analyzed to retrieve information about the original target. The retrieved signature was then compared to the original to obtain a figure of merit: hence the term "end-to-end modeling and analysis." We base the EEM in physics to ensure high fidelity and to permit scaling. As the actual design of the payload evolves, and as real hardware is tested, we can update the EEM to facilitate trade studies, and to judge, for example, whether components that deviate from specifications are acceptable.

  20. Biomechanical considerations in the design of graft: the homeostasis hypothesis.

    Kassab, Ghassan S; Navia, José A


    Since its inception in the 1960s, coronary artery bypass graft (CABG) evolved as one of the most common, best documented, and most effective of all major surgical treatments for ischemic heart disease. Despite its widespread use, however, the outcome is not always completely satisfactory. The objective of this review is to highlight the physical determinants of biomechanical design of CABG so that future procedures would have prolonged patency and better outcome. Our central axiom postulates the existence of a mechanical homeostatic state of the blood vessel, i.e., the variation in vessel wall stresses and strains are relatively small under physiological conditions. Any perturbation of mechanical homeostasis leads to growth and remodeling. In this sense, stenosis and failure of a graft may be viewed as an adaptation process gone awry. We outline the principles of engineering design and discuss the biofluid and biosolid mechanics principles that may have the greatest bearing on mechanical homeostasis and the long-term outcome of CABG.

  1. Design Considerations for High Energy Electron -- Positron Storage Rings

    Richter, B.


    High energy electron-positron storage rings give a way of making a new attack on the most important problems of elementary particle physics. All of us who have worked in the storage ring field designing, building, or using storage rings know this. The importance of that part of storage ring work concerning tests of quantum electrodynamics and mu meson physics is also generally appreciated by the larger physics community. However, I do not think that most of the physicists working tin the elementary particle physics field realize the importance of the contribution that storage ring experiments can make to our understanding of the strongly interacting particles. I would therefore like to spend the next few minutes discussing the sort of things that one can do with storage rings in the strongly interacting particle field.

  2. Design Considerations for Optimized Lateral Spring Structures for Wearable Electronics

    Hussain, Aftab M.


    The market for wearable electronics has been gaining momentum in the recent years. For completely electronic wearable textiles with integrated sensors, actuators, computing units and communication circuitry, it is important that there is significant stretchability. This stretchability can be obtained by introducing periodic stretchable structures between the electronic circuits. In this work, we derive the equations and constraints governing the stretchability in horseshoe lateral spring structures. We have derived the optimum design and the parameters therein, to help develop the best spring structures for a given stretchability. We have also developed a figure of merit, called area efficiency of stretchability, to compare all twodimensional stretchable systems. Finally, we experimentally verify the validity of our equations by fabricating a metal/polymer bilayer thin film based stretchable horseshoe lateral spring structures. We obtain a stretchability of 1.875 which is comparable to the theoretical maxima of 2.01 for the given parameters.

  3. Design and implementation considerations of a MSAT packet data network

    Karam, Fouad G.; Hearn, Terry; Rohr, Doug; Guibord, Arthur F.

    The Mobile Data System, which is intended to provide for packet switched data services is currently under development. The system is based on a star network topology consisting of a centralized Data Hub (DH) serving a large number of mobile terminals. Through the Data Hub, end-to-end connections can be established between terrestrial users on public or private data networks and mobile users. The MDS network will be capable of offering a variety of services some of which are based on the standard X.25 network interface protocol, and others optimized for short messages and broadcast messages. A description of these services and the trade-offs in the DH design are presented.

  4. Some design considerations for small piezo-electrical ceramic transducers

    Rijnja, H. A. J.


    The design parameters and the characteristics of small omnidirectional transducers, to be applied under water as projectors in the frequency range of about 1 kHz to 100 kHz and as hydrophones from very low frequencies up to again 100kHz are described. The transducers are constructed with piezoelectrical ceramic materials in the shape of hollow spheres, end capped tubes or piston (Tonpilz) elements. The highest source levels are obtained with spherical transducers as single omnidirectional sound sources. If larger arrays of sources are applied the array should be composed of single ended Tonpilz elements. The most sensitive receivers (hydrophones) are obtained with tangentially polarized end-capped tubes.

  5. Fuel-cell powered uninterruptible power supply systems: Design considerations

    Choi, Woojin; Howze, Jo. W.; Enjeti, Prasad

    A 1-kVA fuel cell powered, line-interactive uninterruptible power supply (UPS) system that employs modular (fuel cell and power converter) blocks is introduced. Two commercially available proton-exchange membrane fuel cell (25-39 V, 500 W) modules together with suitable dc-dc and dc-ac power electronic converter modules are employed. A supercapacitor module is also used to compensate for the instantaneous power fluctuations and to overcome the slow dynamics of the fuel processor (reformers). Further energy stored in the supercapacitor is also utilized to handle a momentary overload such as 200% for a short duration. Due to the absence of batteries, the system satisfies the demand for an environmentally clean source of energy. A complete design that defines the amount of hydrogen storage required for a power outage of 1 h, and the sizing of the supercapacitors for transient load demand is presented for a 1-kVA UPS.

  6. Technicon H*1 Hematology System: Optical Design Considerations

    Colella, G. M.; Tycko, D. H.; Groner, W.


    The Technicon H*1 systemTM is a clinical laboratory flow cytometer which performs a complete hematology profile, providing quantitative information on the various types of cells in a blood sample. A light-scattering method, using a HeNe laser, determines in a single flow channel the red cell count, platelet count, and the distributions of red cell volume, red cell hemoglobin concentration, and platelet volume. To accomplish this the scattered light from each red cell in the sample is measured in real time at two angular intervals. The cell volume and the hemoglobin concentration within the cell are derived from these two measurements. Severe accuracy and precision specifications are placed on the medically important red cell count (RBC) and the mean red cell volume (MCV). From the point of view of optical system design, the dominant factor is the requirement that RBC and MCV have precision and accuracy of the order of 2%. Signal-to-noise and scattering-angle definition requirements dictated the choice of a HeNe laser light source. The optics includes an illumination system for producing a sharply defined, uniformly illuminated scattering region and a detection system which must accurately define the accepted scattering angles. In previous cytometric methods for determining MCV only a single quantity was measured for each cell. Such methods cannot disentangle the independent effects of cell size and hemoglobin concentration on the measurement, thus compromising MCV accuracy. The present double-angle scattering method overcomes this accuracy problem. The H*1 red cell method, the supporting optical design and data demonstrating that the use of this technique eliminates interference between the observed red cell indices are presented.

  7. Ultra-long fiber Raman lasers: design considerations

    Koltchanov, I.; Kroushkov, D. I.; Richter, A.


    In frame of the European Marie Currie project GRIFFON [] the usage of a green approach in terms of reduced power consumption and maintenance costs is envisioned for long-span fiber networks. This shall be accomplished by coherent transmission in unrepeatered links (100 km - 350 km) utilizing ultra-long Raman fiber laser (URFL)-based distributed amplification, multi-level modulation formats, and adapted Digital Signal Processing (DSP) algorithms. The URFL uses a cascaded 2-order pumping scheme where two (co- and counter-) ˜ 1365 nm pumps illuminate the fiber. The URFL oscillates at ˜ 1450 nm whereas amplification is provided by stimulated Raman scattering (SRS) of the ˜ 1365 nm pumps and the optical feedback is realized by two Fiber Bragg gratings (FBGs) at the fiber ends reflecting at 1450 nm. The light field at 1450 nm provides amplification for signal waves in the 1550 nm range due to SRS. In this work we present URFL design studies intended to characterize and optimize the power and noise characteristics of the fiber links. We use a bidirectional fiber model describing propagation of the signal, pump and noise powers along the fiber length. From the numerical solution we evaluate the on/off Raman gain and its bandwidth, the signal excursion over the fiber length, OSNR spectra, and the accumulated nonlinearities. To achieve best performance for these characteristics the laser design is optimized with respect to the forward/backward pump powers and wavelengths, input/output signal powers, reflectivity profile of the FBGs and other parameters.

  8. Materials for Consideration in Standardized Canister Design Activities.

    Bryan, Charles R.; Ilgen, Anastasia Gennadyevna; Enos, David George; Teich-McGoldrick, Stephanie; Hardin, Ernest


    This document identifies materials and material mitigation processes that might be used in new designs for standardized canisters for storage, transportation, and disposal of spent nuclear fuel. It also addresses potential corrosion issues with existing dual-purpose canisters (DPCs) that could be addressed in new canister designs. The major potential corrosion risk during storage is stress corrosion cracking of the weld regions on the 304 SS/316 SS canister shell due to deliquescence of chloride salts on the surface. Two approaches are proposed to alleviate this potential risk. First, the existing canister materials (304 and 316 SS) could be used, but the welds mitigated to relieve residual stresses and/or sensitization. Alternatively, more corrosion-resistant steels such as super-austenitic or duplex stainless steels, could be used. Experimental testing is needed to verify that these alternatives would successfully reduce the risk of stress corrosion cracking during fuel storage. For disposal in a geologic repository, the canister will be enclosed in a corrosion-resistant or corrosion-allowance overpack that will provide barrier capability and mechanical strength. The canister shell will no longer have a barrier function and its containment integrity can be ignored. The basket and neutron absorbers within the canister have the important role of limiting the possibility of post-closure criticality. The time period for corrosion is much longer in the post-closure period, and one major unanswered question is whether the basket materials will corrode slowly enough to maintain structural integrity for at least 10,000 years. Whereas there is extensive literature on stainless steels, this evaluation recommends testing of 304 and 316 SS, and more corrosion-resistant steels such as super-austenitic, duplex, and super-duplex stainless steels, at repository-relevant physical and chemical conditions. Both general and localized corrosion testing methods would be used to

  9. Design Considerations for RNA Spherical Nucleic Acids (SNAs).

    Barnaby, Stacey N; Perelman, Grant A; Kohlstedt, Kevin L; Chinen, Alyssa B; Schatz, George C; Mirkin, Chad A


    Ribonucleic acids (RNAs) are key components in many cellular processes such as cell division, differentiation, growth, aging, and death. RNA spherical nucleic acids (RNA-SNAs), which consist of dense shells of double-stranded RNA on nanoparticle surfaces, are powerful and promising therapeutic modalities because they confer advantages over linear RNA such as high cellular uptake and enhanced stability. Due to their three-dimensional shell of oligonucleotides, SNAs, in comparison to linear nucleic acids, interact with the biological environment in unique ways. Herein, the modularity of the RNA-SNA is used to systematically study structure-function relationships in order to understand how the oligonucleotide shell affects interactions with a specific type of biological environment, namely, one that contains serum nucleases. We use a combination of experiment and theory to determine the key architectural properties (i.e., sequence, density, spacer moiety, and backfill molecule) that affect how RNA-SNAs interact with serum nucleases. These data establish a set of design parameters for SNA architectures that are optimized in terms of stability.

  10. Design Considerations for Array CGH to OligonucleotideArrays

    Baldocchi, R.A.; Glynne, R.J.; Chin, K.; Kowbel, D.; Collins, C.; Mack, D.H.; Gray, J.W.


    Background: Representational oligonucleotide microarray analysis has been developed for detection of single nucleotide polymorphisms and/or for genome copy number changes. In this process, the intensity of hybridization to oligonucleotides arrays is increased by hybridizing a polymerase chain reaction (PCR)-amplified representation of reduced genomic complexity. However, hybridization to some oligonucleotides is not sufficiently high to allow precise analysis of that portion of the genome. Methods: In an effort to identify aspects of oligonucleotide hybridization affecting signal intensity, we explored the importance of the PCR product strand to which each oligonucleotide is homologous and the sequence of the array oligonucleotides. We accomplished this by hybridizing multiple PCR-amplified products to oligonucleotide arrays carrying two sense and two antisense 50-mer oligonucleotides for each PCR amplicon. Results: In some cases, hybridization intensity depended more strongly on the PCR amplicon strand (i.e., sense vs. antisense) than on the detection oligonucleotide sequence. In other cases, the oligonucleotide sequence seemed to dominate. Conclusion: Oligonucleotide arrays for analysis of DNA copy number or for single nucleotide polymorphism content should be designed to carry probes to sense and antisense strands of each PCR amplicon to ensure sufficient hybridization and signal intensity.

  11. Design considerations and modifications on an optomechatronic load cell

    Camacho P., Alma A.; Martínez Serrano, Francisco Javier; García D., Osvaldo M.


    We have divided this project in stages the first being the construction of an optomechatronics load cell1, the operating principle is based on the fact that the application on a mechanical load produces a deformation on that element. This deformation causes a reduction in the distance between the transmitter and receiver, resulting in a change in the electrical signal. It should be noted that the distribution of light intensity varies between sender and receiver due to the displacement generated. In a load cell, it was adapted an infrared emitter whose signal is received by the detector at the other end. The second stage was the demonstration that our system is able to measure external loads on a mechanical device through an indirect method for measuring stresses, which we present results generated from the experimental trials with adequate mechanical equipment in the cited work. We have implemented a strain sensitive prototype. As a result of the first and second stages to implement the system is to test it on academic applications and then adapt it to industrial environment. Note that the third stage there was a validation of the optomecatronic load cell with ASTM E74-061-2 shows the result with the basic metrological characteristics of resolution, sensitivity, repeatability, which requires it. We are currently analyzing other mechanical design proposals to improve their elastic behavior and the efficiency of this measurement system, because they increase the range of load values at which the expected response should be linear.

  12. Consideration of plant behaviour in optimal servo-compensator design

    Moase, W. H.; Manzie, C.


    Where the most prevalent optimal servo-compensator formulations penalise the behaviour of an error system, this paper considers the problem of additionally penalising the actual states and inputs of the plant. Doing so has the advantage of enabling the penalty function to better resemble an economic cost. This is especially true of problems where control effort needs to be sensibly allocated across weakly redundant inputs or where one wishes to use penalties to soft-constrain certain states or inputs. It is shown that, although the resulting cost function grows unbounded as its horizon approaches infinity, it is possible to formulate an equivalent optimisation problem with a bounded cost. The resulting optimisation problem is similar to those in earlier studies but has an additional 'correction term' in the cost function, and a set of equality constraints that arise when there are redundant inputs. A numerical approach to solve the resulting optimisation problem is presented, followed by simulations on a micro-macro positioner that illustrate the benefits of the proposed servo-compensator design approach.

  13. Design and market considerations for axial flux superconducting electric machine design

    Ainslie, M. D.; George, A.; Shaw, R.; Dawson, L.; Winfield, A.; Steketee, M.; Stockley, S.


    In this paper, the authors investigate a number of design and market considerations for an axial flux superconducting electric machine design that uses high temperature superconductors. The axial flux machine design is assumed to utilise high temperature superconductors in both wire (stator winding) and bulk (rotor field) forms, to operate over a temperature range of 65-77 K, and to have a power output in the range from 10s of kW up to 1 MW (typical for axial flux machines), with approximately 2-3 T as the peak trapped field in the bulk superconductors. The authors firstly investigate the applicability of this type of machine as a generator in small- and medium-sized wind turbines, including the current and forecasted market and pricing for conventional turbines. Next, a study is also carried out on the machine's applicability as an in-wheel hub motor for electric vehicles. Some recommendations for future applications are made based on the outcome of these two studies. Finally, the cost of YBCO-based superconducting (2G HTS) wire is analysed with respect to competing wire technologies and compared with current conventional material costs and current wire costs for both 1G and 2G HTS are still too great to be economically feasible for such superconducting devices.

  14. Nuclear Design Considerations for Z-IFE Chambers

    Meier, W R; Schmitt, R C; Abbott, R P; Latkowski, J F; Reyes, S


    Z-pinch driven IFE (Z-IFE) requires the design of a repetitive target insertion system that allows coupling of the pulsed power to the target with adequate standoff, and a chamber that can withstand blast and radiation effects from large yield targets. The present strategy for Z-IFE is to use high yield targets ({approx}2-3 GJ/shot), low repetition rate per chamber ({approx}0.1 Hz), and 10 chambers per power plant. In this study, we propose an alternative power plant configuration that uses very high yield targets (20 GJ/shot) in a single chamber operating at 0.1 Hz. A thick-liquid-wall chamber is proposed to absorb the target emission (x-rays, debris and neutrons) and mitigate the blast effects on the chamber wall. The target is attached to the end of a conical shaped Recyclable Transmission Line (RTL) made from a solid coolant (e.g., frozen flibe), or a material that is easily separable from the coolant (e.g., steel). The RTL/target assembly is inserted through a single opening at the top of the chamber for each shot. This study looks at the RTL material choice from a safety and environmental point of view. Materials were assessed according to waste disposal rating (WDR) and contact dose rate (CDR). Neutronics calculations, using the TART2002 Monte Carlo code from Lawrence Livermore National Laboratory (LLNL), were performed for the RTL and Z-IFE chamber, and key results reported here.

  15. The SDSS-IV MaNGA Sample: Design, Optimization, and Usage Considerations

    Wake, David A.; Bundy, Kevin; Diamond-Stanic, Aleksandar M.; Yan, Renbin; Blanton, Michael R.; Bershady, Matthew A.; Sánchez-Gallego, José R.; Drory, Niv; Jones, Amy; Kauffmann, Guinevere; Law, David R.; Li, Cheng; MacDonald, Nicholas; Masters, Karen; Thomas, Daniel; Tinker, Jeremy; Weijmans, Anne-Marie; Brownstein, Joel R.


    We describe the sample design for the SDSS-IV MaNGA survey and present the final properties of the main samples along with important considerations for using these samples for science. Our target selection criteria were developed while simultaneously optimizing the size distribution of the MaNGA integral field units (IFUs), the IFU allocation strategy, and the target density to produce a survey defined in terms of maximizing signal-to-noise ratio, spatial resolution, and sample size. Our selection strategy makes use of redshift limits that only depend on i-band absolute magnitude (M i ), or, for a small subset of our sample, M i and color (NUV - i). Such a strategy ensures that all galaxies span the same range in angular size irrespective of luminosity and are therefore covered evenly by the adopted range of IFU sizes. We define three samples: the Primary and Secondary samples are selected to have a flat number density with respect to M i and are targeted to have spectroscopic coverage to 1.5 and 2.5 effective radii (R e ), respectively. The Color-Enhanced supplement increases the number of galaxies in the low-density regions of color-magnitude space by extending the redshift limits of the Primary sample in the appropriate color bins. The samples cover the stellar mass range 5× {10}8≤slant {M}* ≤slant 3× {10}11 {M}⊙ {h}-2 and are sampled at median physical resolutions of 1.37 and 2.5 kpc for the Primary and Secondary samples, respectively. We provide weights that will statistically correct for our luminosity and color-dependent selection function and IFU allocation strategy, thus correcting the observed sample to a volume-limited sample.

  16. 78 FR 66941 - Design Considerations for Pivotal Clinical Investigations for Medical Devices; Guidance for...


    ... for Medical Devices; Guidance for Industry, Clinical Investigators, Institutional Review Boards and... entitled ``Design Considerations for Pivotal Clinical Investigations for Medical Devices.'' This document... premarket submissions for medical devices and for FDA staff who review those submissions. This...

  17. Lunar Module ECS (Environmental Control System) - Design Considerations and Failure Modes. Part 1

    Interbartolo, Michael


    Design considerations and failure modes for the Lunar Module (LM) Environmental Control System (ECS) are described. An overview of the the oxygen supply and cabin pressurization, atmosphere revitalization, water management and heat transport systems are provided. Design considerations including reliability, flight instrumentation, modularization and the change to the use of batteries instead of fuel cells are discussed. A summary is provided for the LM ECS general testing regime.

  18. Particulate Matter Filtration Design Considerations for Crewed Spacecraft Life Support Systems

    Agui, Juan H.; Vijayakumar, R.; Perry, Jay L.


    Particulate matter filtration is a key component of crewed spacecraft cabin ventilation and life support system (LSS) architectures. The basic particulate matter filtration functional requirements as they relate to an exploration vehicle LSS architecture are presented. Particulate matter filtration concepts are reviewed and design considerations are discussed. A concept for a particulate matter filtration architecture suitable for exploration missions is presented. The conceptual architecture considers the results from developmental work and incorporates best practice design considerations.

  19. A new type of dehydration unit of natural gas and its design considerations

    LIU Hengwei; LIU Zhongliang; ZHANG Jian; GU Keyu; YAN Tingmin


    A new type of dehydration unit for natural gas is described and its basic structure and working principles are presented.The key factors affecting the performance and dehydration efficiency of the unit such as nucleation rate, droplet growth rate, the strength of the swirl, and the position at which the shock wave occurs are discussed. And accordingly the design considerations of each component of the unit are provided. Experimental investigations on the working performance of the unit justified the design considerations.

  20. Designing the primary mirror support for the E-ELT

    Nijenhuis, J.R.; Heijmans, J.A.C.; Breeje, R. de; Hazelebach, R.L.M.; Vreugd, J. de; Crowcombe, W.E.; Naron, D.J.; Fritz, E.C.; Borghi, G.; Navarro, R.; Sillari, L.; Sambenedetto, E.; Eder, J.; Kamphues, F.G.


    Described is the M1 segment support, as designed by TNO in the period 2015- 2016. The design has significantly changed and improved compared to the earlier designs. During the period 2009-2010 prototypes for the primary mirror support of the E-ELT have been developed. These have been extensively tes

  1. Interim design status and operational report for remote handling fixtures: primary and secondary burners

    Burgoyne, R.M.


    The HTGR reprocessing flowsheet consists of two basic process elements: (1) spent fuel crushing and burning and (2) solvent extraction. Fundamental to these elements is the design and development of specialized process equipment and support facilities. A major consideration of this design and development program is equipment maintenance: specifically, the design and demonstration of selected remote maintenance capabilities and the integration of these into process equipment design. This report documents the current status of the development of remote handling and maintenance fixtures for the primary and secondary burners.

  2. Designing A Mixed Methods Study In Primary Care

    Creswell, John W.; Fetters, Michael D.; Ivankova, Nataliya V.


    BACKGROUND Mixed methods or multimethod research holds potential for rigorous, methodologically sound investigations in primary care. The objective of this study was to use criteria from the literature to evaluate 5 mixed methods studies in primary care and to advance 3 models useful for designing such investigations.

  3. Designing A Mixed Methods Study In Primary Care

    Creswell, John W.; Fetters, Michael D.; Ivankova, Nataliya V.


    BACKGROUND Mixed methods or multimethod research holds potential for rigorous, methodologically sound investigations in primary care. The objective of this study was to use criteria from the literature to evaluate 5 mixed methods studies in primary care and to advance 3 models useful for designing such investigations.

  4. Teaching science and technology at primary school level: theoretical and practical considerations for primary school teachers' professional training.

    Walma van der Molen, Juliëtte H.; Aalderen-Smeets, van Sandra I.; Asma, Lieke J.F.


    This paper focuses on the importance of starting science and technology education at a young age and at the consequential importance of providing primary school teachers with enough professional background to be able to effectively incorporate science and technology into their teaching. We will disc

  5. LUTE primary mirror materials and design study report

    Ruthven, Greg


    The major objective of the Lunar Ultraviolet Telescope Experiment (LUTE) Primary Mirror Materials and Design Study is to investigate the feasibility of the LUTE telescope primary mirror. A systematic approach to accomplish this key goal was taken by first understanding the optical, thermal, and structural requirements and then deriving the critical primary mirror-level requirements for ground testing, launch, and lunar operations. After summarizing the results in those requirements which drove the selection of material and the design for the primary mirror are discussed. Most important of these are the optical design which was assumed to be the MSFC baseline (i.e. 3 mirror optical system), telescope wavefront error (WFE) allocations, the telescope weight budget, and the LUTE operational temperature ranges. Mechanical load levels, reflectance and microroughness issues, and options for the LUTE metering structure were discussed and an outline for the LUTE telescope sub-system design specification was initiated. The primary mirror analysis and results are presented. The six material substrate candidates are discussed and four distinct mirror geometries which are considered are shown. With these materials and configurations together with varying the location of the mirror support points, a total of 42 possible primary mirror designs resulted. The polishability of each substrate candidate was investigated and a usage history of 0.5 meter and larger precision cryogenic mirrors (the operational low end LUTE temperature of 60 K is the reason we feel a survey of cryogenic mirrors is appropriate) that were flown or tested are presented.

  6. Evolution of design considerations in complex craniofacial reconstruction using patient-specific implants.

    Peel, Sean; Bhatia, Satyajeet; Eggbeer, Dominic; Morris, Daniel S; Hayhurst, Caroline


    Previously published evidence has established major clinical benefits from using computer-aided design, computer-aided manufacturing, and additive manufacturing to produce patient-specific devices. These include cutting guides, drilling guides, positioning guides, and implants. However, custom devices produced using these methods are still not in routine use, particularly by the UK National Health Service. Oft-cited reasons for this slow uptake include the following: a higher up-front cost than conventionally fabricated devices, material-choice uncertainty, and a lack of long-term follow-up due to their relatively recent introduction. This article identifies a further gap in current knowledge - that of design rules, or key specification considerations for complex computer-aided design/computer-aided manufacturing/additive manufacturing devices. This research begins to address the gap by combining a detailed review of the literature with first-hand experience of interdisciplinary collaboration on five craniofacial patient case studies. In each patient case, bony lesions in the orbito-temporal region were segmented, excised, and reconstructed in the virtual environment. Three cases translated these digital plans into theatre via polymer surgical guides. Four cases utilised additive manufacturing to fabricate titanium implants. One implant was machined from polyether ether ketone. From the literature, articles with relevant abstracts were analysed to extract design considerations. In all, 19 frequently recurring design considerations were extracted from previous publications. Nine new design considerations were extracted from the case studies - on the basis of subjective clinical evaluation. These were synthesised to produce a design considerations framework to assist clinicians with prescribing and design engineers with modelling. Promising avenues for further research are proposed.

  7. Primary packaging considerations in developing medicines for children: oral liquid and powder for constitution.

    Campbell, Gossett A; Vallejo, Erick


    The packaging presentation of oral liquid pediatric medicines is a critical step in maintaining chemical and physical stability, compliance, adherence, and proper handling by the target patient population, guardians, caregivers, and health-care professionals. The common packaging presentations for commercial oral liquid pediatric drug products are glass bottle, plastic bottle, sachet, and stick pack configurations. The type of pack presentation selected is driven by the quality target product profile (QTPP) that is designed around the physicochemical properties of the drug substance and the desired drug product suitability for the target population. The QTPP defines the intended use of the drug product, drug product quality criteria, dose strength, dosage form, container closure system, storage conditions, stability criteria, dosing device, shelf life, and attributes affecting the pharmacokinetic characteristics. Oral liquid pediatric formulations are typically prepared from a powder that is constituted at the time of use as a suspension or a solution for single or multiple use depending on the stability of the constituted formulation. Active ingredients with high aqueous solubility can be developed as a powder for oral solution and presented in a bottle for multiple use product and a stick pack, packet, or sachet for single-use product. Active ingredients with low aqueous solubility can be developed as a powder for oral suspension and presented in a bottle for multiple use product and a stick pack or sachet for single-use product. A secondary package may be used in cases where the primary pack failed to provide adequate protection against light degradation. This work will help formulation scientists select the most appropriate pack presentation in the early stages of pediatric clinical development. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

  8. Epidemiological study and considerations of primary focal hyperhidrosis in Japan: from questionnaire analysis.

    Fujimoto, Tomoko; Kawahara, Kazuo; Yokozeki, Hiroo


    Primary hyperhidrosis is a disorder of excessive, bilateral and relatively symmetrical sweating occurring in the palms, soles and axillae regions without obvious etiology. There have been some reports of the epidemiology of primary hyperhidrosis abroad so far, but there has never been any research performed in Japan. We performed a questionnaire survey for people aged 5-64 years who agreed with the purpose of this study at 20 companies or schools, and received 5807 valid responses. From this survey, each prevalence could broken down into 5.33% for primary palm hyperhidrosis, 2.79% for primary plantar hyperhidrosis, 5.75% for primary axillae hyperhidrosis and 4.7% for primary head hyperhidrosis. Patients with severe symptoms were estimated to be approximately 616,000 for primary palmar hyperhidrosis and 2,239,000 for primary axillae hyperhidrosis in Japan. These findings reveal that many patients feel a decreased quality of life because of symptoms of hyperhidrosis every day. However, only 6.2% of the patients had visited medical institutions. Moreover, few patients take appropriate treatment even after visiting the hospital.

  9. Periodontal and space maintenance considerations for primary teeth presenting with aggressive periodontitis: a case report.

    Hazan-Molina, Hagai; Zigdon, Hadar; Einy, Shmuel; Aizenbud, Dror


    Aggressive periodontitis is diagnosed mainly by clinical and radiographic examination. Diagnosis in the primary dentition indicates a choice between conservative and radical treatment that involves extractions, depending on the severity of the case. The purpose of this report was to present a case of aggressive periodontitis in a systemically healthy child and to discuss the periodontal and orthodontic aspects. A 7-year-old girl presented with bleeding on probing of approximately half of the dentition, deep periodontal pockets around all primary molars, and increased tooth mobility. An individual oral hygiene program was initiated. The primary maxillary right molar and all primary mandibular molars were extracted, and clear vacuum-formed removable retainers were fabricated and used as space maintainers. The patient was followed longitudinally for 2 years, and no space loss was recorded. Clear vacuum-formed removable retainers mainly involve occlusal crown attachment and, therefore, decrease the risk of plaque accumulation, gingival irritation, and aggressive periodontitis in the permanent dentition.

  10. Research design considerations for single-dose analgesic clinical trials in acute pain

    Cooper, Stephen A; Desjardins, Paul J; Turk, Dennis C


    This article summarizes the results of a meeting convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) on key considerations and best practices governing the design of acute pain clinical trials. We discuss the role of early phase clinical trials......, including pharmacokinetic-pharmacodynamic (PK-PD) trials, and the value of including both placebo and active standards of comparison in acute pain trials. This article focuses on single-dose and short-duration trials with emphasis on the perioperative and study design factors that influence assay...... sensitivity. Recommendations are presented on assessment measures, study designs, and operational factors. Although most of the methodological advances have come from studies of postoperative pain after dental impaction, bunionectomy, and other surgeries, the design considerations discussed are applicable...

  11. Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations.

    Cooper, Stephen A; Desjardins, Paul J; Turk, Dennis C; Dworkin, Robert H; Katz, Nathaniel P; Kehlet, Henrik; Ballantyne, Jane C; Burke, Laurie B; Carragee, Eugene; Cowan, Penney; Croll, Scott; Dionne, Raymond A; Farrar, John T; Gilron, Ian; Gordon, Debra B; Iyengar, Smriti; Jay, Gary W; Kalso, Eija A; Kerns, Robert D; McDermott, Michael P; Raja, Srinivasa N; Rappaport, Bob A; Rauschkolb, Christine; Royal, Mike A; Segerdahl, Märta; Stauffer, Joseph W; Todd, Knox H; Vanhove, Geertrui F; Wallace, Mark S; West, Christine; White, Richard E; Wu, Christopher


    This article summarizes the results of a meeting convened by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) on key considerations and best practices governing the design of acute pain clinical trials. We discuss the role of early phase clinical trials, including pharmacokinetic-pharmacodynamic (PK-PD) trials, and the value of including both placebo and active standards of comparison in acute pain trials. This article focuses on single-dose and short-duration trials with emphasis on the perioperative and study design factors that influence assay sensitivity. Recommendations are presented on assessment measures, study designs, and operational factors. Although most of the methodological advances have come from studies of postoperative pain after dental impaction, bunionectomy, and other surgeries, the design considerations discussed are applicable to many other acute pain studies conducted in different settings.

  12. Some Considerations Regarding the Design and Implementation of Data Warehouse in Insurance Broker Management

    Alexandru Manole


    Full Text Available This paper describes a proposal for a data warehouse model, designed for the use in the management of insurance brokerage companies. The model aims to provide information to the leadership of such companies, beyond the classical knowledge drawn from current activity reports. Also, the design process took into consideration the characteristics of the business model analysed. The model is then “exploited” by making some analyses on the data loaded.

  13. 77 FR 74195 - Draft Guidance for Industry and Food and Drug Administration Staff; Design Considerations for...


    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Design Considerations for Devices Intended for Home Use; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  14. Designing the Best Urban, Preservice Elementary Science Methods Course: Dilemmas and Considerations

    Moscovici, Hedy; Osisioma, Irene


    This paper addresses the dilemmas encountered by two secondary science education instructors designing a course for preservice elementary teachers. Taking into consideration past experiences of teaching education and science courses in general and with preservice elementary teachers in particular and recommendations from state and national…

  15. Precision and cost considerations for two-stage sampling in a panelized forest inventory design.

    Westfall, James A; Lister, Andrew J; Scott, Charles T


    Due to the relatively high cost of measuring sample plots in forest inventories, considerable attention is given to sampling and plot designs during the forest inventory planning phase. A two-stage design can be efficient from a field work perspective as spatially proximate plots are grouped into work zones. A comparison between subsampling with units of unequal size (SUUS) and a simple random sample (SRS) design in a panelized framework assessed the statistical and economic implications of using the SUUS design for a case study in the Northeastern USA. The sampling errors for estimates of forest land area and biomass were approximately 1.5-2.2 times larger with SUUS prior to completion of the inventory cycle. Considerable sampling error reductions were realized by using the zones within a post-stratified sampling paradigm; however, post-stratification of plots in the SRS design always provided smaller sampling errors in comparison. Cost differences between the two designs indicated the SUUS design could reduce the field work expense by 2-7 %. The results also suggest the SUUS design may provide substantial economic advantage for tropical forest inventories, where remote areas, poor access, and lower wages are typically encountered.

  16. Design Considerations of Very Low Profile Coupled Inductors for Flexible Photovoltaic Module

    Ouyang, Ziwei; Acanski, M; Popovic, J


    important design issues for the sandwich core structure including self-inductance, leakage inductance, eddy current effect and core loss are analyzed in-depth in this work. Since the non-uniform flux is distributed in the core plates, the parameters calculation and the design considerations are completely......Power converters with flexible PCB integrated magnetic components are highly demanded in future photovoltaic (PV) applications, resulting in a higher power density. In this paper, a 1.5-mm thickness integrated coupled inductor with planar sandwich core structure is under investigation. Several...... different with the traditional magnetic approaches. Accordingly, this paper enables original design considerations as a guideline for sandwiched coupled inductor. In order to reduce the high frequency eddy current effect in sandwich core structure, section III initiates a discussion with adjustable core...

  17. Web-based assessments of physical activity in youth: considerations for design and scale calibration.

    Saint-Maurice, Pedro F; Welk, Gregory J


    This paper describes the design and methods involved in calibrating a Web-based self-report instrument to estimate physical activity behavior. The limitations of self-report measures are well known, but calibration methods enable the reported information to be equated to estimates obtained from objective data. This paper summarizes design considerations for effective development and calibration of physical activity self-report measures. Each of the design considerations is put into context and followed by a practical application based on our ongoing calibration research with a promising online self-report tool called the Youth Activity Profile (YAP). We first describe the overall concept of calibration and how this influences the selection of appropriate self-report tools for this population. We point out the advantages and disadvantages of different monitoring devices since the choice of the criterion measure and the strategies used to minimize error in the measure can dramatically improve the quality of the data. We summarize strategies to ensure quality control in data collection and discuss analytical considerations involved in group- vs individual-level inference. For cross-validation procedures, we describe the advantages of equivalence testing procedures that directly test and quantify agreement. Lastly, we introduce the unique challenges encountered when transitioning from paper to a Web-based tool. The Web offers considerable potential for broad adoption but an iterative calibration approach focused on continued refinement is needed to ensure that estimates are generalizable across individuals, regions, seasons and countries.

  18. Robotic Observatory System Design-Specification Considerations for Achieving Long-Term Sustainable Precision Performance

    Wray, J. D.


    The robotic observatory telescope must point precisely on the target object, and then track autonomously to a fraction of the FWHM of the system PSF for durations of ten to twenty minutes or more. It must retain this precision while continuing to function at rates approaching thousands of observations per night for all its years of useful life. These stringent requirements raise new challenges unique to robotic telescope systems design. Critical design considerations are driven by the applicability of the above requirements to all systems of the robotic observatory, including telescope and instrument systems, telescope-dome enclosure systems, combined electrical and electronics systems, environmental (e.g. seeing) control systems and integrated computer control software systems. Traditional telescope design considerations include the effects of differential thermal strain, elastic flexure, plastic flexure and slack or backlash with respect to focal stability, optical alignment and angular pointing and tracking precision. Robotic observatory design must holistically encapsulate these traditional considerations within the overall objective of maximized long-term sustainable precision performance. This overall objective is accomplished through combining appropriate mechanical and dynamical system characteristics with a full-time real-time telescope mount model feedback computer control system. Important design considerations include: identifying and reducing quasi-zero-backlash; increasing size to increase precision; directly encoding axis shaft rotation; pointing and tracking operation via real-time feedback between precision mount model and axis mounted encoders; use of monolithic construction whenever appropriate for sustainable mechanical integrity; accelerating dome motion to eliminate repetitive shock; ducting internal telescope air to outside dome; and the principal design criteria: maximizing elastic repeatability while minimizing slack, plastic deformation

  19. Apollo CSM Power Generation System Design Considerations, Failure Modes and Lessons Learned

    Interbartolo, Michael


    The objectives of this slide presentation are to: review the basic design criteria for fuel cells (FC's), review design considerations during developmental phase that affected Block I and Block II vehicles, summarize the conditions that led to the failure of components in the FC's, and state the solution implemented for each failure. It reviews the location of the fuel cells, the fuel cell theory the design criteria going into development phase and coming from the development phase, failures and solutions of Block I and II, and the lessons learned.

  20. Numerical methods and a computer program for subsonic and supersonic aerodynamic design and analysis of wings with attainable thrust considerations

    Carlson, H. W.; Walkley, K. B.


    This paper describes methodology and an associated computer program for the design of wing lifting surfaces with attainable thrust taken into consideration. The approach is based on the determination of an optimum combination of a series of candidate surfaces rather than the more commonly used candidate loadings. Special leading-edge surfaces are selected to provide distributed leading-edge thrust forces which compensate for any failure to achieve the full theoretical leading-edge thrust, and a second series of general candidate surfaces is selected to minimize drag subject to constraints on the lift coefficient and, if desired, on the pitching moment coefficient. A primary purpose of the design approach is the introduction of attainable leading-edge thrust considerations so that relatively mild camber surfaces may be employed in the achievement of aerodynamic efficiencies comparable to those attainable if full theoretical leading-edge thrust could be achieved. The program provides an analysis as well as a design capability and is applicable to both subsonic and supersonic flow.

  1. Design Considerations of a Transverse Flux Machine for Direct-Drive Wind Turbine Applications

    Husain, Tausif; Hasan, Iftekhar; Sozer, Yilmaz; Husain, Iqbal; Muljadi, Eduard


    This paper presents the design considerations of a double-sided transverse flux machine (TFM) for direct-drive wind turbine applications. The TFM has a modular structure with quasi-U stator cores and ring windings. The rotor is constructed with ferrite magnets in a flux-concentrating arrangement to achieve high air gap flux density. The design considerations for this TFM with respect to initial sizing, pole number selection, key design ratios, and pole shaping are presented in this paper. Pole number selection is critical in the design process of a TFM because it affects both the torque density and power factor under fixed magnetic and changing electrical loading. Several key design ratios are introduced to facilitate the design procedure. The effect of pole shaping on back-emf and inductance is also analyzed. These investigations provide guidance toward the required design of a TFM for direct-drive applications. The analyses are carried out using analytical and three-dimensional finite element analysis. A prototype is under construction for experimental verification.

  2. Design Considerations of a Transverse Flux Machine for Direct-Drive Wind Turbine Applications: Preprint

    Husain, Tausif; Hasan, Iftekhar; Sozer, Yilmaz; Husain, Iqbal; Muljadi, Eduard


    This paper presents the design considerations of a double-sided transverse flux machine (TFM) for direct-drive wind turbine applications. The TFM has a modular structure with quasi-U stator cores and ring windings. The rotor is constructed with ferrite magnets in a flux-concentrating arrangement to achieve high air gap flux density. The design considerations for this TFM with respect to initial sizing, pole number selection, key design ratios, and pole shaping are presented in this paper. Pole number selection is critical in the design process of a TFM because it affects both the torque density and power factor under fixed magnetic and changing electrical loading. Several key design ratios are introduced to facilitate the design procedure. The effect of pole shaping on back-emf and inductance is also analyzed. These investigations provide guidance toward the required design of a TFM for direct-drive applications. The analyses are carried out using analytical and three-dimensional finite element analysis. A prototype is under construction for experimental verification.

  3. Novel dose-finding designs and considerations on practical implementations in oncology clinical trials.

    Huang, Bo; Bycott, Paul; Talukder, Enayet


    One of the main objectives in phase I oncology trials is to evaluate safety and tolerability of an experimental treatment by estimating the maximum tolerated dose (MTD) based on the rate of dose-limiting toxicities (DLT). To meet emerging challenges in dose-finding studies, over the past two decades, extensive research has been conducted by statistical and medical researchers to create innovative dose finding designs that perform better than the standard 3 + 3 design, which often exhibits undesirable statistical and operational properties. However, clinical implementation and practical usage of these new designs have been limited. This article begins with a review of the most recent literature and then provides some perspectives on implementing novel adaptive dose finding designs in oncology phase I trials from a pharmaceutical industry perspective. Statistical planning and logistical considerations on how to effectively execute such designs in multi-center clinical trials are discussed using two recent case studies.

  4. Memories and NASA Spacecraft: A Description of Memories, Radiation Failure Modes, and System Design Considerations

    LaBel, Kenneth A.; Ladbury, Ray; Oldhamm, Timothy


    As NASA has evolved it's usage of spaceflight computing, memory applications have followed as well. In this slide presentation, the history of NASA's memories from magnetic core and tape recorders to current semiconductor approaches is discussed. There is a brief description of current functional memory usage in NASA space systems followed by a description of potential radiation-induced failure modes along with considerations for reliable system design.

  5. A consideration of education programs for gifted primary school pupils in Masvingo, Zimbabwe

    Manyowa, A.F.


    Full Text Available An exploratory study reported here sought to consider and obtain baseline information on educational programs for gifted pupils available in primary schools in the City of Masvingo, Zimbabwe. A sample of 40 regular class teachers, selected from 9 of the 13 primary schools completed questionnaires that sought to establish categories of giftedness and identification methods used in the schools. The teachers were then asked to nominate children they considered gifted who had received some educational program that could be deemed specific for gifted children. 198 pupils were selected from the different grades using this purposive sampling method. A questionnaire that sought information from children on the educational provisions available in the schools was administered. Teachers named children they considered gifted across all the categories. All methods of identification save achievement tests were found to be used in the schools. Nine forms of educational provision for gifted learners were identified from the children’s responses. It is suggested that further research focusing on content and sequence of knowledge and skills being taught in the various gifted education provisions be carried out so as to answer questions of appropriateness.

  6. Design and Analysis of an Efficient Primary Synchronization Signal Detector



    Full Text Available In this paper, we present a novel design for the detection of primary synchronization signal in a Long Term Evolution (LTE system based device at the expense of low cost and low power. This is facilitated by using a matched filter architecture which incorporates parallel processing. The approach of a 1-bit analog-todigital converter (ADC with down-sampling is compared with that of a 10-bit ADC without down-sampling under multi-path fading conditions defined in LTE standard for user equipment (UE performance test. A high performance primary synchronization signal detection method is derived in this paper.

  7. Considerations in the design of a communication network for an autonomously managed power system

    Mckee, J. W.; Whitehead, Norma; Lollar, Louis


    The considerations involved in designing a communication network for an autonomously managed power system intended for use in space vehicles are examined. An overview of the design and implementation of a communication network implemented in a breadboard power system is presented. An assumption that the monitoring and control devices are distributed but physically close leads to the selection of a multidrop cable communication system. The assumption of a high-quality communication cable in which few messages are lost resulted in a simple recovery procedure consisting of a time out and retransmit process.

  8. Residential hospice environments: evidence-based architectural and landscape design considerations.

    Verderber, Stephen


    The residential hospice care movement is increasingly accepted and supported globally, and yet, unfortunately, the amount of literature on best practices in the planning and design of residential hospice facilities and adjacent outdoor spaces remains relatively small. This paper reports on a compendium of architectural and landscape design considerations that reflect the fundamental dimensions of the residential hospice experience: site and context, arrival spaces, communal and private spaces of the residential milieu, transitional spaces, and nature connectivity. Additionally, key staffing and administrative ramifications of this built-environment compendium are addressed, as are prognostications and challenges for the future.

  9. Designing for Motivation: Design-Considerations for Spaced-Repetition-Based Learning Games on Mobile Devices

    Schimanke, Florian; Mertens, Robert; Vornberger, Oliver


    Learning games are an ideal vessel for many kinds of learning content. Playful interaction with the subject matter makes the human mind more receptive and thus learning itself more effective. Well designed games also come with an addictive game-play that makes users want to play the game over and over. This is intended in fun games but it can be…

  10. Single-case research design in pediatric psychology: considerations regarding data analysis.

    Cohen, Lindsey L; Feinstein, Amanda; Masuda, Akihiko; Vowles, Kevin E


    Single-case research allows for an examination of behavior and can demonstrate the functional relation between intervention and outcome in pediatric psychology. This review highlights key assumptions, methodological and design considerations, and options for data analysis. Single-case methodology and guidelines are reviewed with an in-depth focus on visual and statistical analyses. Guidelines allow for the careful evaluation of design quality and visual analysis. A number of statistical techniques have been introduced to supplement visual analysis, but to date, there is no consensus on their recommended use in single-case research design. Single-case methodology is invaluable for advancing pediatric psychology science and practice, and guidelines have been introduced to enhance the consistency, validity, and reliability of these studies. Experts generally agree that visual inspection is the optimal method of analysis in single-case design; however, statistical approaches are becoming increasingly evaluated and used to augment data interpretation.

  11. Process cost and facility considerations in the selection of primary cell culture clarification technology.

    Felo, Michael; Christensen, Brandon; Higgins, John


    The bioreactor volume delineating the selection of primary clarification technology is not always easily defined. Development of a commercial scale process for the manufacture of therapeutic proteins requires scale-up from a few liters to thousands of liters. While the separation techniques used for protein purification are largely conserved across scales, the separation techniques for primary cell culture clarification vary with scale. Process models were developed to compare monoclonal antibody production costs using two cell culture clarification technologies. One process model was created for cell culture clarification by disc stack centrifugation with depth filtration. A second process model was created for clarification by multi-stage depth filtration. Analyses were performed to examine the influence of bioreactor volume, product titer, depth filter capacity, and facility utilization on overall operating costs. At bioreactor volumes cost savings compared to clarification using centrifugation. For bioreactor volumes >5,000 L, clarification using centrifugation followed by depth filtration offers significant cost savings. For bioreactor volumes of ∼ 2,000 L, clarification costs are similar between depth filtration and centrifugation. At this scale, factors including facility utilization, available capital, ease of process development, implementation timelines, and process performance characterization play an important role in clarification technology selection. In the case study presented, a multi-product facility selected multi-stage depth filtration for cell culture clarification at the 500 and 2,000 L scales of operation. Facility implementation timelines, process development activities, equipment commissioning and validation, scale-up effects, and process robustness are examined. © 2013 American Institute of Chemical Engineers.

  12. Implementing evidence-based patient self-management programs in the Veterans Health Administration: perspectives on delivery system design considerations.

    Damush, T M; Jackson, G L; Powers, B J; Bosworth, H B; Cheng, E; Anderson, J; Guihan, M; LaVela, S; Rajan, S; Plue, L


    While many patient self-management (PSM) programs have been developed and evaluated for effectiveness, less effort has been devoted to translating and systematically delivering PSM in primary and specialty care. Therefore, the purpose of this paper is to review delivery system design considerations for implementing self-management programs in practice. As lessons are learned about implementing PSM programs in Veterans Health Administration (VHA), resource allocation by healthcare organization for formatting PSM programs, providing patient access, facilitating PSM, and incorporating support tools to foster PSM among its consumers can be refined and tailored. Redesigning the system to deliver and support PSM will be important as implementation researchers translate evidence based PSM practices into routine care and evaluate its impact on the health-related quality of life of veterans living with chronic disease.

  13. 76 FR 68198 - Lists of Designated Primary Medical Care, Mental Health, and Dental Health Professional Shortage...


    ... Administration Lists of Designated Primary Medical Care, Mental Health, and Dental Health Professional Shortage... designated as primary medical care, mental health, and dental health professional shortage areas (HPSAs) as... seven health professional types (primary medical care, dental, psychiatric, vision care,...

  14. Analysis and design consideration of mean temperature differential Stirling engine for solar application

    Tlili, Iskander; Timoumi, Youssef; Nasrallah, Sassi Ben [Laboratoire d' Etude des Systemes Thermiques et Energetiques Ecole Nationale d' Ingenieurs de Monastir, Rue Ibn El Jazzar, 5019 Monastir (Tunisia)


    This article presents a technical innovation, study of solar power system based on the Stirling dish (SD) technology and design considerations to be taken in designing of a mean temperature differential Stirling engine for solar application. The target power source will be solar dish/Stirling with average concentration ratio, which will supply a constant source temperature of 320{sup o}C. Hence, the system design is based on a temperature difference of 300{sup o}C, assuming that the sink is kept at 20{sup o}C. During the preliminary design stage, the critical parameters of the engine design are determined according to the dynamic model with losses energy and pressure drop in heat exchangers was used during the design optimisation stage in order to establish a complete analytical model for the engine. The heat exchangers are designed to be of high effectiveness and low pressure-drop. Upon optimisation, for given value of difference temperature, operating frequency and dead volume there is a definite optimal value of swept volume at which the power is a maximum. The optimal swept volume of 75 cm{sup 3} for operating frequency 75 Hz with the power is 250 W and the dead volume is of 370 cm{sup 3}. (author)

  15. System and antenna design considerations for highly elliptical orbits as applied to the proposed Archimedes Constellation

    Paynter, C.; Cuchanski, M.


    The paper discusses various aspects of the system design for a satellite in a highly elliptical inclined orbit, and presents a number of antenna design options for the proposed Archimedes mission. A satellite constellation was studied for the provision of multi media communication services in the L and S Band for northern latitudes. The inclined elliptical orbit would allow coverage of Europe, America, and East Asia. Using Canada and North America as the baseline coverage area, this paper addresses system considerations such as the satellite configuration and pointing, beam configuration, and requirements for antennas. A trade-off is performed among several antenna candidates including a direct radiating array, a focal-fed reflector, and a single reflector imaging system. Antenna geometry, performance, and beam forming methods are described. The impact of the designs on the antenna deployment is discussed.

  16. Some important considerations in the design of a quiet compressor station

    Binek, J.


    Some considerations in the design of power generating plants using natural gas compressors were discussed from the point of view of noise control, affecting not only operating personnel but also residents in the surrounding community. Among these were: (1) determination of noise sources (engine inlet, engine casing, engine exhaust, booster compressor, yard piping and valves, gas aftercoolers, blow-off valves), (2) understanding sound attenuation phenomena (hemispheric divergence, wind, temperature, molecular absorption and ground cover), (3) the importance of low frequency noise, and (4) the shortcomings of dBA as a noise descriptor. Noise control systems should be designed concurrently with the design of the new facility, or the expansion of an old one, recognizing that peaceful coexistence with the surrounding community is an essential ingredient of success. 7 refs., 12 figs.

  17. Zebrafish housing systems: a review of basic operating principles and considerations for design and functionality.

    Lawrence, Christian; Mason, Timothy


    The strategies for housing zebrafish used in biomedical research have evolved considerably over the past three decades. To keep pace with the rapid expansion and development of the zebrafish model system, the field has generally moved from keeping fish at the level of aquarium hobbyist to that of industrialized, recirculating aquaculture. Numerous commercial system vendors now offer increasingly sophisticated housing systems based on design principles that maximize the number of animals that can be housed in a given space footprint, and they are thus able to support large and diverse research programs. This review is designed to provide managers, lab animal veterinarians, investigators, and other parties responsible for care and use of these animals with a comprehensive overview of the basic operating and design principles of zebrafish housing systems. This information can be used to help plan the construction of new facilities and/or the upgrade and maintenance of existing operations.

  18. Designing A Mixed Methods Study In Primary Care

    Creswell, John W.; Fetters, Michael D.; Ivankova, Nataliya V.


    BACKGROUND Mixed methods or multimethod research holds potential for rigorous, methodologically sound investigations in primary care. The objective of this study was to use criteria from the literature to evaluate 5 mixed methods studies in primary care and to advance 3 models useful for designing such investigations. METHODS We first identified criteria from the social and behavioral sciences to analyze mixed methods studies in primary care research. We then used the criteria to evaluate 5 mixed methods investigations published in primary care research journals. RESULTS Of the 5 studies analyzed, 3 included a rationale for mixing based on the need to develop a quantitative instrument from qualitative data or to converge information to best understand the research topic. Quantitative data collection involved structured interviews, observational checklists, and chart audits that were analyzed using descriptive and inferential statistical procedures. Qualitative data consisted of semistructured interviews and field observations that were analyzed using coding to develop themes and categories. The studies showed diverse forms of priority: equal priority, qualitative priority, and quantitative priority. Data collection involved quantitative and qualitative data gathered both concurrently and sequentially. The integration of the quantitative and qualitative data in these studies occurred between data analysis from one phase and data collection from a subsequent phase, while analyzing the data, and when reporting the results. DISCUSSION We recommend instrument-building, triangulation, and data transformation models for mixed methods designs as useful frameworks to add rigor to investigations in primary care. We also discuss the limitations of our study and the need for future research. PMID:15053277

  19. Material Control and Accounting Design Considerations for High-Temperature Gas Reactors

    Trond Bjornard; John Hockert


    The subject of this report is domestic safeguards and security by design (2SBD) for high-temperature gas reactors, focusing on material control and accountability (MC&A). The motivation for the report is to provide 2SBD support to the Next Generation Nuclear Plant (NGNP) project, which was launched by Congress in 2005. This introductory section will provide some background on the NGNP project and an overview of the 2SBD concept. The remaining chapters focus specifically on design aspects of the candidate high-temperature gas reactors (HTGRs) relevant to MC&A, Nuclear Regulatory Commission (NRC) requirements, and proposed MC&A approaches for the two major HTGR reactor types: pebble bed and prismatic. Of the prismatic type, two candidates are under consideration: (1) GA's GT-MHR (Gas Turbine-Modular Helium Reactor), and (2) the Modular High-Temperature Reactor (M-HTR), a derivative of Areva's Antares reactor. The future of the pebble-bed modular reactor (PBMR) for NGNP is uncertain, as the PBMR consortium partners (Westinghouse, PBMR [Pty] and The Shaw Group) were unable to agree on the path forward for NGNP during 2010. However, during the technology assessment of the conceptual design phase (Phase 1) of the NGNP project, AREVA provided design information and technology assessment of their pebble bed fueled plant design called the HTR-Module concept. AREVA does not intend to pursue this design for NGNP, preferring instead a modular reactor based on the prismatic Antares concept. Since MC&A relevant design information is available for both pebble concepts, the pebble-bed HTGRs considered in this report are: (1) Westinghouse PBMR; and (2) AREVA HTR-Module. The DOE Office of Nuclear Energy (DOE-NE) sponsors the Fuel Cycle Research and Development program (FCR&D), which contains an element specifically focused on the domestic (or state) aspects of SBD. This Material Protection, Control and Accountancy Technology (MPACT) program supports the present work

  20. Design Considerations and Experimental Verification of a Rail Brake Armature Based on Linear Induction Motor Technology

    Sakamoto, Yasuaki; Kashiwagi, Takayuki; Hasegawa, Hitoshi; Sasakawa, Takashi; Fujii, Nobuo

    This paper describes the design considerations and experimental verification of an LIM rail brake armature. In order to generate power and maximize the braking force density despite the limited area between the armature and the rail and the limited space available for installation, we studied a design method that is suitable for designing an LIM rail brake armature; we considered adoption of a ring winding structure. To examine the validity of the proposed design method, we developed a prototype ring winding armature for the rail brakes and examined its electromagnetic characteristics in a dynamic test system with roller rigs. By repeating various tests, we confirmed that unnecessary magnetic field components, which were expected to be present under high speed running condition or when a ring winding armature was used, were not present. Further, the necessary magnetic field component and braking force attained the desired values. These studies have helped us to develop a basic design method that is suitable for designing the LIM rail brake armatures.

  1. Design considerations for a LORAN-C timing receiver in a hostile signal to noise environment

    Porter, J. W.; Bowell, J. R.; Price, G. E.


    The environment in which a LORAN-C Timing Receiver may function effectively depends to a large extent on the techniques utilized to insure that interfering signals within the pass band of the unit are neutralized. The baseline performance manually operated timing receivers is discussed and the basic design considerations and necessary parameters for an automatic unit utilizing today's technology are established. Actual performance data is presented comparing the results obtained from a present generation timing receiver against a new generation microprocessor controlled automatic acquisition receiver. The achievements possible in a wide range of signal to noise situations are demonstrated.

  2. Note: Design considerations and characterization of a flexible snapshot hyperspectral probe

    Lim, Hoong-Ta; Murukeshan, Vadakke Matham


    Hyperspectral imaging is a combination of imaging and spectroscopy to give detailed spectral information for each spatial point in the imaged scene. Using the concept of integral field spectroscopy, a custom fabricated two-dimensional to one-dimensional fiber bundle has recently been reported. It is used as a flexible snapshot hyperspectral probe, which can be used as an endoscope for biomedical applications. This paper reports on the design considerations of the fiber bundle as the flexible probe in the snapshot hyperspectral imaging system. The physical characterization of the custom fabricated fiber bundle and lateral resolution of the developed hyperspectral imaging system are also analyzed and described.

  3. Optimization of the National Ignition Facility primary shield design

    Annese, C.E.; Watkins, E.F.; Greenspan, E.; Miller, W.F. [California Univ., Berkeley, CA (United States). Dept. of Nuclear Engineering; Latkowski, J.; Lee, J.D.; Soran, P.; Tobin, M.L. [Lawrence Livermore National Lab., CA (United States)


    Minimum cost design concepts of the primary shield for the National Ignition laser fusion experimental Facility (NIF) are searched with the help of the optimization code SWAN. The computational method developed for this search involves incorporating the time dependence of the delayed photon field within effective delayed photon production cross sections. This method enables one to address the time-dependent problem using relatively simple, time-independent transport calculations, thus significantly simplifying the design process. A novel approach was used for the identification of the optimal combination of constituents that will minimize the shield cost; it involves the generation, with SWAN, of effectiveness functions for replacing materials on an equal cost basis. The minimum cost shield design concept was found to consist of a mixture of polyethylene and low cost, low activation materials such as SiC, with boron added near the shield boundaries.

  4. Design considerations for a time-resolved tomographic diagnostic at DARHT

    Morris I. Kaufman, Daniel Frayer, Wendi Dreesen, Douglas Johnson, Alfred Meidinger


    An instrument has been developed to acquire time-resolved tomographic data from the electron beam at the DARHT [Dual-Axis Radiographic Hydrodynamic Test] facility at Los Alamos National Laboratory. The instrument contains four optical lines of sight that view a single tilted object. The lens design optically integrates along one optical axis for each line of sight. These images are relayed via fiber optic arrays to streak cameras, and the recorded streaks are used to reconstruct the original two-dimensional data. Installation of this instrument into the facility requires automation of both the optomechanical adjustments and calibration of the instrument in a constrained space. Additional design considerations include compound tilts on the object and image planes.

  5. Design Considerations for Scalable High-Performance Vision Systems Embedded in Industrial Print Inspection Machines

    Rössler Peter


    Full Text Available This paper describes the design of a scalable high-performance vision system which is used in the application area of optical print inspection. The system is able to process hundreds of megabytes of image data per second coming from several high-speed/high-resolution cameras. Due to performance requirements, some functionality has been implemented on dedicated hardware based on a field programmable gate array (FPGA, which is coupled to a high-end digital signal processor (DSP. The paper discusses design considerations like partitioning of image processing algorithms between hardware and software. The main chapters focus on functionality implemented on the FPGA, including low-level image processing algorithms (flat-field correction, image pyramid generation, neighborhood operations and advanced processing units (programmable arithmetic unit, geometry unit. Verification issues for the complex system are also addressed. The paper concludes with a summary of the FPGA resource usage and some performance results.

  6. The TSU Streaming Video Astronomy Course - II, Video Interface Design and Bandwidth Considerations

    Burks, G. S.; Smith, W.


    Researchers are developing an on-line video astronomy course at Tennessee State University. Many factors are taken into account when designing a first year course for a broad audience. The initial target audience is students attending historically black colleges and universities, tribal colleges, and other minority institutions, without an astronomy course. The primary goal is to attract students into a course of study that could prepare them to enter the NASA workforce. A secondary goal is to serve the general student population. The question we try to address here is: How can we deliver the video components of such a course in a way that will take into account the innate learning styles of most students and the limited access to very high speed internet lines in smaller colleges? The design for the video information interface will be discussed. The effect of limited bandwidth on video size and other features of the presentation design is also analyzed.

  7. Planning Considerations for a Mars Sample Receiving Facility: Summary and Interpretation of Three Design Studies

    Beaty, David W.; Allen, Carlton C.; Bass, Deborah S.; Buxbaum, Karen L.; Campbell, James K.; Lindstrom, David J.; Miller, Sylvia L.; Papanastassiou, Dimitri A.


    It has been widely understood for many years that an essential component of a Mars Sample Return mission is a Sample Receiving Facility (SRF). The purpose of such a facility would be to take delivery of the flight hardware that lands on Earth, open the spacecraft and extract the sample container and samples, and conduct an agreed-upon test protocol, while ensuring strict containment and contamination control of the samples while in the SRF. Any samples that are found to be non-hazardous (or are rendered non-hazardous by sterilization) would then be transferred to long-term curation. Although the general concept of an SRF is relatively straightforward, there has been considerable discussion about implementation planning. The Mars Exploration Program carried out an analysis of the attributes of an SRF to establish its scope, including minimum size and functionality, budgetary requirements (capital cost, operating costs, cost profile), and development schedule. The approach was to arrange for three independent design studies, each led by an architectural design firm, and compare the results. While there were many design elements in common identified by each study team, there were significant differences in the way human operators were to interact with the systems. In aggregate, the design studies provided insight into the attributes of a future SRF and the complex factors to consider for future programmatic planning.

  8. Planning considerations for a Mars Sample Receiving Facility: summary and interpretation of three design studies.

    Beaty, David W; Allen, Carlton C; Bass, Deborah S; Buxbaum, Karen L; Campbell, James K; Lindstrom, David J; Miller, Sylvia L; Papanastassiou, Dimitri A


    It has been widely understood for many years that an essential component of a Mars Sample Return mission is a Sample Receiving Facility (SRF). The purpose of such a facility would be to take delivery of the flight hardware that lands on Earth, open the spacecraft and extract the sample container and samples, and conduct an agreed-upon test protocol, while ensuring strict containment and contamination control of the samples while in the SRF. Any samples that are found to be non-hazardous (or are rendered non-hazardous by sterilization) would then be transferred to long-term curation. Although the general concept of an SRF is relatively straightforward, there has been considerable discussion about implementation planning. The Mars Exploration Program carried out an analysis of the attributes of an SRF to establish its scope, including minimum size and functionality, budgetary requirements (capital cost, operating costs, cost profile), and development schedule. The approach was to arrange for three independent design studies, each led by an architectural design firm, and compare the results. While there were many design elements in common identified by each study team, there were significant differences in the way human operators were to interact with the systems. In aggregate, the design studies provided insight into the attributes of a future SRF and the complex factors to consider for future programmatic planning.

  9. Advanced tokamak reactors based on the spherical torus (ATR/ST). Preliminary design considerations

    Miller, R.L.; Krakowski, R.A.; Bathke, C.G.; Copenhaver, C.; Schnurr, N.M.; Engelhardt, A.G.; Seed, T.J.; Zubrin, R.M.


    Preliminary design results relating to an advanced magnetic fusion reactor concept based on the high-beta, low-aspect-ratio, spherical-torus tokamak are summarized. The concept includes resistive (demountable) toroidal-field coils, magnetic-divertor impurity control, oscillating-field current drive, and a flowing liquid-metal breeding blanket. Results of parametric tradeoff studies, plasma engineering modeling, fusion-power-core mechanical design, neutronics analyses, and blanket thermalhydraulics studies are described. The approach, models, and interim results described here provide a basis for a more detailed design. Key issues quantified for the spherical-torus reactor center on the need for an efficient drive for this high-current (approx.40 MA) device as well as the economic desirability to increase the net electrical power from the nominal 500-MWe(net) value adopted for the baseline system. Although a direct extension of present tokamak scaling, the stablity and transport of this high-beta (approx.0.3) plasma is a key unknown that is resoluble only by experiment. The spherical torus generally provides a route to improved tokamak reactors as measured by considerably simplified coil technology in a configuration that allows a realistic magnetic divertor design, both leading to increased mass power density and reduced cost.

  10. Technical considerations for designing low-cost, long-wave infrared objectives

    Desroches, Gerard; Dalzell, Kristy; Robitaille, Blaise


    With the growth of uncooled infrared imaging in the consumer market, the balance between cost implications and performance criteria in the objective lens must be examined carefully. The increased availability of consumer-grade, long-wave infrared cameras is related to a decrease in military usage but it is also due to the decreasing costs of the cameras themselves. This has also driven up demand for low-cost, long-wave objectives that can resolve smaller pixels while maintaining high performance. Smaller pixels are traditionally associated with high cost objectives because of higher resolution requirements but, with careful consideration of all the requirements and proper selection of materials, costs can be moderated. This paper examines the cost/performance trade-off implications associated with optical and mechanical requirements of long-wave infrared objectives. Optical performance, f-number, field of view, distortion, focus range and thermal range all affect the cost of the objective. Because raw lens material cost is often the most expensive item in the construction, selection of the material as well as the shape of the lens while maintaining acceptable performance and cost targets were explored. As a result of these considerations, a low-cost, lightweight, well-performing objective was successfully designed, manufactured and tested.

  11. Some considerations for establishing seismic design criteria for nuclear plant piping

    Chen, W.P. [Energy Technology Engineering Center, Canoga Park, CA (United States); Chokshi, N.C. [Nuclear Regulatory Commission, Washington, DC (United States)


    The Energy Technology Engineering Center (ETEC) is providing assistance to the U.S. NRC in developing regulatory positions on the seismic analysis of piping. As part of this effort, ETEC previously performed reviews of the ASME Code, Section III piping seismic design criteria as revised by the 1994 Addenda. These revised criteria were based on evaluations by the ASME Special Task Group on Integrated Piping Criteria (STGIPC) and the Technical Core Group (TCG) of the Advanced Reactor Corporation (ARC) of the earlier joint Electric Power Research Institute (EPRI)/NRC Piping & Fitting Dynamic Reliability (PFDR) program. Previous ETEC evaluations reported at the 23rd WRSM of seismic margins associated with the revised criteria are reviewed. These evaluations had concluded, in part, that although margins for the timed PFDR tests appeared acceptable (>2), margins in detuned tests could be unacceptable (<1). This conclusion was based primarily on margin reduction factors (MRFs) developed by the ASME STGIPC and ARC/TCG from realistic analyses of PFDR test 36. This paper reports more recent results including: (1) an approach developed for establishing appropriate seismic margins based on PRA considerations, (2) independent assessments of frequency effects on margins, (3) the development of margins based on failure mode considerations, and (4) the implications of Code Section III rules for Section XI.

  12. Carbon dioxide mineralization process design and evaluation: concepts, case studies, and considerations.

    Yuen, Yeo Tze; Sharratt, Paul N; Jie, Bu


    Numerous carbon dioxide mineralization (CM) processes have been proposed to overcome the slow rate of natural weathering of silicate minerals. Ten of these proposals are mentioned in this article. The proposals are described in terms of the four major areas relating to CM process design: pre-treatment, purification, carbonation, and reagent recycling operations. Any known specifics based on probable or representative operating and reaction conditions are listed, and basic analysis of the strengths and shortcomings associated with the individual process designs are given in this article. The processes typically employ physical or chemical pseudo-catalytic methods to enhance the rate of carbon dioxide mineralization; however, both methods have its own associated advantages and problems. To examine the feasibility of a CM process, three key aspects should be included in the evaluation criteria: energy use, operational considerations as well as product value and economics. Recommendations regarding the optimal level of emphasis and implementation of measures to control these aspects are given, and these will depend very much on the desired process objectives. Ultimately, a mix-and-match approach to process design might be required to provide viable and economic proposals for CM processes.

  13. Consideration of neutral beam prompt loss in the design of a tokamak helicon antenna

    Pace, D.C., E-mail:; Van Zeeland, M.A.; Fishler, B.; Murphy, C.


    Highlights: • Neutral beam prompt losses place appreciable power on an in-vessel tokamak antenna. • Simulations predict prompt loss power and inform protective tile design. • Experiments confirm the validity of the prompt loss simulations. - Abstract: Neutral beam prompt losses (injected neutrals that ionize such that their first poloidal transit intersects with the wall) can put appreciable power on the outer wall of tokamaks, and this power may damage the wall or other internal components. These prompt losses are simulated including a protruding helicon antenna installation in the DIII-D tokamak and it is determined that 160 kW of power will impact the antenna during the injection of a particular neutral beam. Protective graphite tiles are designed in response to this modeling and the wall shape of the installed antenna is precisely measured to improve the accuracy of these calculations. Initial experiments confirm that the antenna component temperature increases according to the amount of neutral beam energy injected into the plasma. In this case, only injection of beams that are aimed counter to the plasma current produce an appreciable power load on the outer wall, suggesting that the effect is of little concern for tokamaks featuring only co-current neutral beam injection. Incorporating neutral beam prompt loss considerations into the design of this in-vessel component serves to ensure that adequate protection or cooling is provided.

  14. Bioequivalence study designs for generic solid oral anticancer drug products: scientific and regulatory considerations.

    Kaur, Paramjeet; Chaurasia, Chandra S; Davit, Barbara M; Conner, Dale P


    The demonstration of bioequivalence (BE) between the test and reference products is an integral part of generic drug approval process. A sound BE study design is pivotal to the successful demonstration of BE of generic drugs to their corresponding reference listed drug product. Generally, BE of systemically acting oral dosage forms is demonstrated in a crossover, single-dose in vivo study in healthy subjects. The determination of BE of solid oral anticancer drug products is associated with its own unique challenges due to the serious safety risks involved. Unlike typical BE study in healthy subjects, the safety issues often necessitate conducting BE studies in cancer patients. Such BE studies of an anticancer drug should be conducted without disturbing the patients' therapeutic dosing regimen. Attributes such as drug permeability and solubility, pharmacokinetics, dosing regimen, and approved therapeutic indication(s) are considered in the BE study design of solid anticancer drug products. To streamline the drug approval process, the Division of Bioequivalence posts the Bioequivalence Recommendations for Specific Products guidances on the FDA public website. The objective of this article is to illustrate the scientific and regulatory considerations in the design of BE studies for generic solid oral anticancer drug products through examples.

  15. Facts learnt from the Hanshin-Awaji disaster and consideration on design basis earthquake

    Shibata, Heki [Yokohama National Univ. (Japan). Faculty of Engineering


    This paper will deal with how to establish the concept of the design basis earthquake for critical industrial facilities such as nuclear power plants in consideration of disasters induced by the 1995 Hyogoken-Nanbu Earthquake (Southern Hyogo-prefecture Earthquake-1995), so-called Kobe earthquake. The author once discussed various DBEs at 7 WCEE. At that time, the author assumed that the strongest effective PGA would be 0.7 G, and compared to the values of accelerations to a structure obtained by various codes in Japan and other countries. The maximum PGA observed by an instrument at the Southern Hyogo-pref. Earthquake-1995 exceeded the previous assumption of the author, even though the evaluation results of the previous paper had been pessimistic. According to the experience of Kobe event, the author will point out the necessity of the third earthquake S{sub s} adding to S{sub 1} and S{sub 2}, previous DBEs. (author)

  16. BPM Design and Impedance Considerations for a Rotatable Collimator for the LHC Collimation Upgrade

    Smith, Jeffrey Claiborne; /SLAC; Keller, Lewis; /SLAC; Lundgren, Steven; /SLAC; Markiewicz, Thomas; /SLAC; Young, Andrew; /SLAC


    The Phase II upgrade to the LHC collimation system calls for complementing the 30 high robust Phase I graphite secondary collimators with 30 high Z Phase II collimators. This paper reports on BPM and impedance considerations and measurements of the integrated BPMs in the prototype rotatable collimator to be installed in the Super Proton Synchrotron (SPS) at CERN. The BPMs are necessary to align the jaws with the beam. Without careful design the beam impedance can result in unacceptable heating of the chamber wall or beam instabilities. The impedance measurements involve utilizing both a single displaced wire and two wires excited in opposite phase to disentangle the driving and detuning transverse impedances. Trapped mode resonances and longitudinal impedance are to also be measured and compared with simulations. These measurements, when completed, will demonstrate the device is fully operational and has the impedance characteristics and BPM performance acceptable for installation in the SPS.

  17. Integrated design and evaluation of biomass energy system taking into consideration demand side characteristics

    Ren, Hongbo [Ritsumeikan Global Innovation Research Organization, Ritsumeikan University, 56-1 Toji-in Kitamachi, Kita-Ku, 603-8577 Kyoto (Japan); Zhou, Weisheng; Nakagami, Ken' ichi [College of Policy Sciences, Ritsumeikan University, 603-8577 Kyoto (Japan); Gao, Weijun [Faculty of Environmental Engineering, The University of Kitakyushu, 808-0135 Kitakyushu (Japan)


    In this paper, a linear programming model has been developed for the design and evaluation of biomass energy system, while taking into consideration demand side characteristics. The objective function to be minimized is the total annual cost of the energy system for a given customer equipped with a biomass combined cooling, heating and power (CCHP) plant, as well as a backup boiler fueled by city gas. The results obtained from the implementation of the model demonstrate the optimal system capacities that customers could employ given their electrical and thermal demands. As an illustrative example, an investigation addresses the optimal biomass CCHP system for a residential area located in Kitakyushu Science and Research Park, Japan. In addition, sensitivity analyses have been elaborated in order to show how the optimal solutions would vary due to changes of some key parameters including electricity and city gas tariffs, biogas price, electricity buy-back price, as well as carbon tax rate. (author)

  18. System considerations and RF front-end design for integration of satellite navigation and mobile standards

    A. Miskiewicz


    Full Text Available The paper presents the challenges involved in a system design of a robust reconfigurable RF front-end for navigation and mobile standards. Receiver architecture is chosen from the point of view of inter-system interference and 130nm CMOS process characteristics. System concept covers the implementation of GPS, Galileo, UMTS, GSM and CDMA2000 using a Zero-IF architecture with reconfigurable analog and digital path. Feasibility studies of the system cover analysis of the wireless regulations and performance criteria, such as overall gain, noise figure (NF, and 1dB compression point (P1dB of the RF chain, phase noise requirements and VCO tuning range [1]. The presented chip was fabricated in 130 nm CMOS technology. System considerations are confirmed with the chip measurements of gain, noise figure, and linearity. Prospects for the future work are presented including technology shrink.

  19. How many patients are needed? Variation and design considerations in bone histomorphometry.

    Hauge, E M; Mosekilde, L; Melsen, F; Frydenberg, M


    In osteoporosis research, bone histomorphometry plays an important role in documenting the biological effects and possible side-effects of new drug treatments. To ensure that the study is properly scaled, it is important to be concerned with the risk of type II error; that is, the risk of failing to detect a real difference. We therefore calculated the necessary sample size in bone histomorphometric studies according to a specified difference of 15% between two groups. The calculations were based on variance components estimated from three different studies: women with a distal fracture of the forearm (n = 22); patients with pituitary insufficiency (n = 21); and patients with primary hyperparathyroidism (n = 21). Using a significance level of 0.05 and a risk of type II error of 0.20, the statistical power of two different designs was compared: a single biopsy design comparing the responses in two groups after the treatment; and a paired biopsy design in which individual differences (posttreatment minus baseline) were calculated before the comparison of the two groups. We found that the mineral apposition rate, wall thickness, and erosion depth are statistically powerful indices that, in the single biopsy design, require no more than n = 25 in each group to detect differences of 15% between the groups. Bone volume, erosion surface, osteoid surface, mineralizing surface, and activation frequency need group sizes of 100-600 individuals to find a 15% difference to be statistically significant. However, the effect of bisphosphonate treatment, for instance, is large enough to reduce the group size to 20 individuals concerning activation frequency. The remodeling balance reaches extreme group sizes of several thousand for a 15% difference to be statistically significant, but for a 5 microm (approximately 150%) improvement, about 100 individuals are required in the single biopsy design. An analysis of the components of variance showed that the variation between individuals

  20. Design Considerations for Attitude State Awareness and Prevention of Entry into Unusual Attitudes

    Ellis, Kyle K. E.; Prinzel, Lawrence J., III; Arthur, Jarvis J.; Nicholas, Stephanie N.; Kiggins, Daniel; Verstynen, Harry; Hubbs, Clay; Wilkerson, James


    Loss of control - inflight (LOC-I) has historically represented the largest category of commercial aviation fatal accidents. A review of the worldwide transport airplane accidents (2001-2010) evinced that loss of attitude or energy state awareness was responsible for a large majority of the LOC-I events. A Commercial Aviation Safety Team (CAST) study of 18 worldwide loss-of-control accidents and incidents determined that flight crew loss of attitude awareness or energy state awareness due to lack of external visual reference cues was a significant causal factor in 17 of the 18 reviewed flights. CAST recommended that "Virtual Day-Visual Meteorological Condition" (Virtual Day-VMC) displays be developed to provide the visual cues necessary to prevent loss-of-control resulting from flight crew spatial disorientation and loss of energy state awareness. Synthetic vision or equivalent systems (SVS) were identified for a design "safety enhancement" (SE-200). Part of this SE involves the conduct of research for developing minimum aviation system performance standards (MASPS) for these flight deck display technologies to aid flight crew attitude and energy state awareness similar to that of a virtual day-VMC-like environment. This paper will describe a novel experimental approach to evaluating a flight crew's ability to maintain attitude awareness and to prevent entry into unusual attitudes across several SVS optical flow design considerations. Flight crews were subjected to compound-event scenarios designed to elicit channelized attention and startle/surprise within the crew. These high-fidelity scenarios, designed from real-world events, enable evaluation of the efficacy of SVS at improving flight crew attitude awareness to reduce the occurrence of LOC-I incidents in commercial flight operations.

  1. Design considerations for massively parallel sequencing studies of complex human disease.

    Bing-Jian Feng

    Full Text Available Massively Parallel Sequencing (MPS allows sequencing of entire exomes and genomes to now be done at reasonable cost, and its utility for identifying genes responsible for rare Mendelian disorders has been demonstrated. However, for a complex disease, study designs need to accommodate substantial degrees of locus, allelic, and phenotypic heterogeneity, as well as complex relationships between genotype and phenotype. Such considerations include careful selection of samples for sequencing and a well-developed strategy for identifying the few "true" disease susceptibility genes from among the many irrelevant genes that will be found to harbor rare variants. To examine these issues we have performed simulation-based analyses in order to compare several strategies for MPS sequencing in complex disease. Factors examined include genetic architecture, sample size, number and relationship of individuals selected for sequencing, and a variety of filters based on variant type, multiple observations of genes and concordance of genetic variants within pedigrees. A two-stage design was assumed where genes from the MPS analysis of high-risk families are evaluated in a secondary screening phase of a larger set of probands with more modest family histories. Designs were evaluated using a cost function that assumes the cost of sequencing the whole exome is 400 times that of sequencing a single candidate gene. Results indicate that while requiring variants to be identified in multiple pedigrees and/or in multiple individuals in the same pedigree are effective strategies for reducing false positives, there is a danger of over-filtering so that most true susceptibility genes are missed. In most cases, sequencing more than two individuals per pedigree results in reduced power without any benefit in terms of reduced overall cost. Further, our results suggest that although no single strategy is optimal, simulations can provide important guidelines for study design.

  2. Design considerations for remotely operated welding in space: Task definition and visual weld monitoring experiment

    Reynerson, Charles M.


    This thesis explores the concept of welding in a space environment with the use of automation. Since the amount of time astronauts can work outside a spacecraft is limited, future construction and repair tasks will likely be assisted by automation. It is also likely that remote space welding will be needed for the construction of large-scale space structures in earth orbit as well as for lunar and Martian ground-based structures. Due to the complex nature of the tasks to be accomplished, the equipment will probably not be fully autonomous but instead supervised by a human operator. The welding fabrication problem in space is examined in a broad sense including some of the considerations for designing a human supervisory remote welding system. The history of space welding processes is examined, as well as current research in the field. A task definition and functional analysis is provided to assist future designers in outlining typical operational sequences for such a remote welding system. Such analysis is important when deciding whether the human operator should perform certain tasks or if the operator should supervise the automated system while it performs the tasks.

  3. Design considerations and experimental results for MRI systems using HTS magnets

    Parkinson, Ben


    An increasing number of magnetic resonance imaging (MRI) systems using high temperature superconductors (HTS) magnets have been designed and constructed, with detailed results of their performance now available. Features of REBCO and BSCCO conductors are described as they pertain to use in high homogeneity magnets, with emphasis placed on the practical use of these conductors in magnets. Methods of coil winding are discussed, in particular the differences between pancake and layer winding techniques. Design considerations for HTS magnets are presented in light of the difficulties presented by quench in these magnets, but also in terms of the features of HTS magnets afforded by their high operating temperatures, namely robust cryogen free operation and the potential to use unshielded gradient coils. Drawing on two example MRI systems, namely a 3 T BSCCO brain imaging magnet developed in Japan and a 1.5 T REBCO orthopaedic imaging system developed in New Zealand, the report details real-world stability and homogeneity of HTS-MRI systems, in particular with regards to the screening current effects observed in these systems. It is concluded that, apart from conductor cost, there are currently no technical obstacles to use of HTS-MRI systems.

  4. Statistical design considerations applicable to clinical trials of iodine supplementation in pregnant women who may be mildly iodine deficient.

    Troendle, James F


    No large, randomized, placebo-controlled trial of iodine supplementation in pregnant women in a region of mild or moderate iodine deficiency has been completed in which a primary outcome measure was an assessment of the neurobehavioral development of the offspring at age ≥2 y. In this article, I discuss considerations for the design of such a trial in a region of mild iodine deficiency, with a focus on statistical methods and approaches. Exposure and design issues include the ethics of using a placebo, the potential for overexposure to iodine, and the possibility of community randomization. The main scientific goal of the trial is important in determining the follow-up period. If the goal is to determine whether iodine supplementation during pregnancy improves neurobehavioral development in the offspring, then follow-up should continue until a reasonably reliable assessment can be conducted, which might be at age ≥2 y. Once the timing of assessment is decided, the impact of potential loss to follow-up should be considered so that appropriate statistical methods can be incorporated into the design. The minimum sample size can be calculated by using a sample size formula that incorporates noncompliance and assumes that a certain proportion of study participants do not have any outcome observed. To have sufficient power to detect a reasonably modest difference in neurobehavioral development scores using an assessment tool with an SD of 15, a large number of participants (>500/group) is required. The minimum adequate number of participants may be even larger (>1300/group) depending on the magnitude of the difference in outcome between the supplementation and placebo groups, the estimated proportion of the iodine-supplementation group that fails to take the supplement, and the estimated proportion of pregnancies that do not produce outcome measurements.

  5. Launch and Functional Considerations Guiding the Scaling and Design of Rigid Inflatable Habitat Modules

    Bell, L.


    The Sasakawa International Center for Space Architecture (SICSA) has a long history of projects that involve design of space structures, including habitats for low-Earth orbit (LEO) and planetary applications. Most of these facilities and component systems are planned to comply with size, geometry and mass restrictions imposed by the Space Shuttle Orbiter's payload and lift/landing abort restrictions. These constraints limit launch elements to approximately 15 ft. diameter, 40 ft. long cylindrical dimensions weighing no more than approximately 25 metric tons. It is clear that future success of commercial space programs such as tourism will hinge upon the availability of bigger and more efficient Earth to LEO launch vehicles which can greatly reduce transportation and operational costs. This will enable development and utilization of larger habitat modules and other infrastructure elements which can be deployed with fewer launches and on-orbit assembly procedures. The sizing of these new heavy lift launchers should be scaled to optimize habitat functionality and efficiency, just as the habitat designs must consider optimization of launch vehicle economy. SICSA's planning studies address these vehicle and habitat optimization priorities as parallel and interdependent considerations. The allowable diameter of habitat modules established by launch vehicle capacity dictates functionally acceptable internal configuration options. Analyses of these options relative to practical dimensions for Earth-to-orbit launch vehicle scaling were conducted for two general schemes. The "bologna slice" configuration stacks the floors within a predominately cylindrical or spherical envelope, producing circular areas. The "banana split" approach divides a cylindrical module longitudinally, creating floors that are generally rectangular in shape. The assessments established minimum sizes for reasonable utility and efficiency. The bologna slice option. This configuration is only acceptable

  6. Design Considerations for the Nuclear Thermal Rocket Element Environmental Simulator (NTREES)

    Emrich, Bill; Kirk, Daniel


    Nuclear Thermal Rockets or NTR's have been suggested as a propulsion system option for vehicles traveling to the moon or Mars. These engines are capable of providing high thrust at specific impulses at least twice that of today s best chemical engines. The performance constraints on these engines are mainly the result of temperature limitations on the fuel coupled with a limited ability to withstand chemical attack by the hot hydrogen propellant. To operate at maximum efficiency, fuel forms are desired which can withstand the extremely hot, hostile environment characteristic of NTR operation for at least several hours. The simulation of such an environment would require an experimental device which could simultaneously approximate the power, flow, and temperature conditions which a nuclear fuel element (or partial element) would encounter during NTR operation. Such a simulation would allow detailed studies of the fuel behavior and hydrogen flow characteristics under reactor like conditions to be performed. The goal of these simulations would be directed toward expanding the performance envelope of NTR engines over that which was demonstrated during the Rover and NERVA nuclear rocket programs of the 1970's. Currently, such a simulator is nearing completion at the Marshall Space Flight Center, and will shortly be used in the future to evaluate a wide variety of he1 element designs and the materials of which they are constructed. This present work addresses the initial experimental objectives of the Nuclear Thermal Rocket Element Environmental Simulator or NTREES and some of the design considerations which were considered prior to and during its construction.

  7. The SpeX Prism Library Analysis Toolkit: Design Considerations and First Results

    Burgasser, Adam J.; Aganze, Christian; Escala, Ivana; Lopez, Mike; Choban, Caleb; Jin, Yuhui; Iyer, Aishwarya; Tallis, Melisa; Suarez, Adrian; Sahi, Maitrayee


    Various observational and theoretical spectral libraries now exist for galaxies, stars, planets and other objects, which have proven useful for classification, interpretation, simulation and model development. Effective use of these libraries relies on analysis tools, which are often left to users to develop. In this poster, we describe a program to develop a combined spectral data repository and Python-based analysis toolkit for low-resolution spectra of very low mass dwarfs (late M, L and T dwarfs), which enables visualization, spectral index analysis, classification, atmosphere model comparison, and binary modeling for nearly 2000 library spectra and user-submitted data. The SpeX Prism Library Analysis Toolkit (SPLAT) is being constructed as a collaborative, student-centered, learning-through-research model with high school, undergraduate and graduate students and regional science teachers, who populate the database and build the analysis tools through quarterly challenge exercises and summer research projects. In this poster, I describe the design considerations of the toolkit, its current status and development plan, and report the first published results led by undergraduate students. The combined data and analysis tools are ideal for characterizing cool stellar and exoplanetary atmospheres (including direct exoplanetary spectra observations by Gemini/GPI, VLT/SPHERE, and JWST), and the toolkit design can be readily adapted for other spectral datasets as well.This material is based upon work supported by the National Aeronautics and Space Administration under Grant No. NNX15AI75G. SPLAT code can be found at


    MĂRCUŞ Liviu


    Full Text Available The high demands for cheap footwear can only be satisfied by mass fabrication. Costumed footwear would represent a regress, despite the advantages that it brings. This paper regards mainly the demands that mass footwear requires, in order to maintain the health of the foot. The desire to maintain the foot shape and functionality requires certain last forms and fabrication algorithms. We analyze certain aspects referring to: the correct design of the inner sole, insuring the flexibility of the lower part of the footwear by choosing the right type of materials and confection systems, choosing the right height of the heel, setting the adequate shape by increasing the number of different shoe sizes. In order to give a loose space to the adults’ toes, where they are not pressed, but have a complete range of motion, the orthopedists and the last specialists have set several requirements for building the contour of the inner sole. The technique of building a bond between the footwear forepart and the inferior ensemble is dependent to the purpose and partially to the fashion demands of the shoe. The sole shape is influenced by the buyers, as seen by the development of the ex-flex footwear. There must be noted that in this case, the work of the model designer coincides with the exigencies of the specialist in footwear health. With the help of certain functional considerations and of several mechanical calculations, it can be proven that a heel with a height of 3 cm does not necessarily have a negative impact on the foot health. This is why even the orthopedics consider this limit as acceptable. Higher heels must be avoided if we want to maintain a normal function and development of the foot.

  9. Design consideration for nano-accuracy long trace profiler at BSRF

    Yang, Fugui; Wang, Lichao; Tang, Shanzhi; Wang, Qiushi; Li, Ming


    The third generation synchrotron radiation source like High Energy Photon Source (HEPS, Beijing) requires X-ray optics surface with high accuracy. It is crucial to develop advanced optics surface metrology instrument. The Long Trace Profiler (LTP) is an instrument which measures slope in the long dimension of an optical surface. In order to meet the accuracy requirements for synchrotron optics, a number of researches have been carried out to improve the LTP during the last decades. Many variations have been installed worldwide. As a part of the advanced research of HEPS, the metrology laboratory at Beijing Synchrotron Radiation Facility (BSRF, Beijing) has been conducting work of building a new LTP since 2012. The accuracy of the instrument is expected to be <0.1μrad rms for component up to 1m in length. In this paper, we present some design consideration for nano-accuracy LTP. Two error sources, including the deformation of the granite structure and imperfect optical surface, are studied. We report our optimized configuration of the granite structure and the dependences of the measurement error on the surface error. The results are considered as an important instruction for the proper choice of each component in the profiler. We expect to bring the profiler into operation in 2015.

  10. Antibiotic-free selection in E. coli: new considerations for optimal design and improved production

    Peubez Isabelle


    Full Text Available Abstract Background The increasing regulatory requirements to which biological agents are subjected will have a great impact in the field of industrial protein expression and production. There is an expectation that in a near future, there may be "zero tolerance" towards antibiotic-based selection and production systems. Besides the antibiotic itself, the antibiotic resistance gene is an important consideration. The complete absence of antibiotic-resistance gene being the only way to ensure that there is no propagation in the environment or transfer of resistance to pathogenic strains. Results In a first step, we have designed a series of vectors, containing a stabilization element allowing a complete elimination of antibiotics during fermentation. Vectors were further improved in order to include alternative selection means such as the well known poison/antidote stabilization system. Eventually we propose an elegant positive pressure of selection ensuring the elimination of the antibiotic-resistance gene through homologous recombination. In addition, we have shown that the presence of an antibiotic resistance gene can indirectly reduce the amount of expressed protein, since even in absence of selection pressure the gene would be transcribed and account for an additional stress for the host during the fermentation process. Conclusions We propose a general strategy combining plasmid stabilization and antibiotic-free selection. The proposed host/vector system, completely devoid of antibiotic resistance gene at the end of construction, has the additional advantage of improving recombinant protein expression and/or plasmid recovery.

  11. Human engineering design considerations for the use of signal color enhancement in ASW displays

    Banks, W.W.


    The Lawrence Livermore National Laboratory (LLNL) was requested to examine and define man-machine limits as part of the Office of Naval Technology's High Gain Initiative program (HGI). As an initial investigative area, LLNL's Systems and Human Performance effort focused upon color display interfaces and the use of color enhancement techniques to define human and system interface limits in signal detection and discrimination tasks. The knowledgeable and prudent use of color in different types of display is believed to facilitate human visual detection, discrimination and recognition in complex visual tasks. The consideration and understanding of the complex set of interacting variables associated with the prudent use of color is essential to optimize human performance, especially in the ASW community. The designers of advanced display technology and signal processing algorithms may be eventually called upon to present pre-processed information to ASW operators and researchers using the latest color enhancement techniques. These techniques, however, may be limited if one does not understand the complexity and limits of human information processing which reflects the assessed state of knowledge relevant to the use of color in displays. The initial sections of this report discuss various aspects of color presentation and the problems typically encountered, while the last section deals with a specific research proposal required to further our understanding and proper use of color enhancement methods.

  12. Beyond Mouse and Keyboard: Expanding Design Considerations for Information Visualization Interactions.

    Lee, Bongshin; Isenberg, P; Riche, N H; Carpendale, S


    The importance of interaction to Information Visualization (InfoVis) and, in particular, of the interplay between interactivity and cognition is widely recognized [12, 15, 32, 55, 70]. This interplay, combined with the demands from increasingly large and complex datasets, is driving the increased significance of interaction in InfoVis. In parallel, there have been rapid advances in many facets of interaction technologies. However, InfoVis interactions have yet to take full advantage of these new possibilities in interaction technologies, as they largely still employ the traditional desktop, mouse, and keyboard setup of WIMP (Windows, Icons, Menus, and a Pointer) interfaces. In this paper, we reflect more broadly about the role of more "natural" interactions for InfoVis and provide opportunities for future research. We discuss and relate general HCI interaction models to existing InfoVis interaction classifications by looking at interactions from a novel angle, taking into account the entire spectrum of interactions. Our discussion of InfoVis-specific interaction design considerations helps us identify a series of underexplored attributes of interaction that can lead to new, more "natural," interaction techniques for InfoVis.

  13. Design considerations regarding slug ruptures in the intermediate power level reactor

    Pearl, W.L.; Pursel, C.A.


    The minimum shutdown time, to permit accessibility, for the Intermediate Power Reactor is estimated to be 38 hours. In case the reactor were shutdown following each rupture this long shutdown period would have serious disadvantages. The desirability of being able to make firm power commitments (independent of slug ruptures) has led to a study of the possibility of continuous operation following a rupture. There is evidence to indicate that, at the proposed water temperature, the rate of corrosion of uranium may be so high that at least a major portion of the rupture products may have entered the system before the reactor can be shutdown. A pushout of the affected column would then be a pushout of only those slugs which are still intact and the problem would still remain of removing the rupture products from the system. The first portion of this report is concerned with the rate of corrosion of a slug following rupture and the possible limitations to the principle of non-shutdown operation. These limitations include a flow stoppage by the ruptured can, undue increase in gamma activity, increased corrosion by the rupture products, and adherence of rupture products to the piping. The latter portion of the document is concerned with design considerations of the shielding and water plant so as to eliminate or minimize the effects of the introduction of rupture products into the cooling system. 7 refs., 2 figs.

  14. Design and Optimization of the SPOT Primary Mirror Segment

    Budinoff, Jason G.; Michaels, Gregory J.


    The 3m Spherical Primary Optical Telescope (SPOT) will utilize a single ring of 0.86111 point-to-point hexagonal mirror segments. The f2.85 spherical mirror blanks will be fabricated by the same replication process used for mass-produced commercial telescope mirrors. Diffraction-limited phasing will require segment-to-segment radius of curvature (ROC) variation of approx.1 micron. Low-cost, replicated segment ROC variations are estimated to be almost 1 mm, necessitating a method for segment ROC adjustment & matching. A mechanical architecture has been designed that allows segment ROC to be adjusted up to 400 microns while introducing a minimum figure error, allowing segment-to-segment ROC matching. A key feature of the architecture is the unique back profile of the mirror segments. The back profile of the mirror was developed with shape optimization in MSC.Nastran(TradeMark) using optical performance response equations written with SigFit. A candidate back profile was generated which minimized ROC-adjustment-induced surface error while meeting the constraints imposed by the fabrication method. Keywords: optimization, radius of curvature, Pyrex spherical mirror, Sigfit

  15. Electrolyte management considerations in modern nickel/hydrogen and nickel/cadmium cell and battery designs

    Thaller, Lawrence H.; Zimmerman, Albert H.

    In the early 1980s, the battery group at the NASA Lewis Research Center (LeRC) reviewed the design issues associated with nickel/hydrogen cells for low-earth orbit applications. In 1984, these issues included gas management, liquid management, plate expansion, and the recombination of oxygen during overcharge. The design effort by that group followed principles set forth in an earlier LeRC paper that introduced the topic of pore size engineering. Also in 1984, the beneficial effect of lower electrolyte concentrations on cycle life was verified by Hughes Aircraft as part of a LeRC-funded study. Subsequent life cycle tests of these concepts have been carried out that essentially have verified all of this earlier work. During the past decade, some of the mysteries involved in the active material of the nickel electrode have been resolved by careful research done at several laboratories. While attention has been paid to understanding and modeling abnormal nickel/hydrogen cell behaviors, not enough attention has been paid to the potassium ion content in these cells, and more recently, in batteries. Examining the potassium ion content of different portions of the cell or battery is a convenient way of following the conductivity, mass transport properties, and electrolyte volume in each of the cell or battery portions under consideration. Several of the consequences of solvent and solute changes within fuel cells have been well known for some time. However, only recently have these consequences been applied to nickel/hydrogen and nickel/cadmium cell designs. As a result of these studies, several unusual cell performance signatures can now be satisfactorily explained in terms of movement of the solvent and solute components in the electrolyte. This paper will review three general areas where the potassium ion content can impact the performance and life of nickel/hydrogen and nickel/cadmium cells. Sample calculations of the concentration or volume changes that can take

  16. Mould design and manufacturing considerations of honeycomb biocomposites with transverse fibre direction for aerospace application

    Manan, N. H.; Majid, D. L.; Romli, F. I.


    Sandwich structures with honeycomb core are known to significantly improve stiffness at lower weight and possess high flexural rigidity. They have found wide applications in aerospace as part of the primary structures, as well as the interior paneling and floors. High performance aluminum and aramid are the typical materials used for the purpose of honeycomb core whereas in other industries, materials such as fibre glass, carbon fibre, Nomex and also Kevlar reinforced with polymer are used. Recently, growing interest in developing composite structures with natural fibre reinforcement has also spurred research in natural fibre honeycomb material. The majority of the researches done, however, have generally emphasized on the usage of random chopped fibre and only a few are reported on development of honeycomb structure using unidirectional fibre as the reinforcement. This is mainly due to its processing difficulties, which often involve several stages to account for the arrangement of fibres and curing. Since the use of unidirectional fibre supports greater strength compared to random chopped fibre, a single-stage process in conjunction with vacuum infusion is suggested with a mould design that supports fibre arrangement in the direction of honeycomb loading.

  17. Cryogenic Considerations for Superconducting Magnet Design for the Material Plasma Exposure eXperiment

    Duckworth, Robert C [ORNL; Demko, Dr. Jonathan A [LeTourneau University, Texas; Lumsdaine, Arnold [ORNL; Caughman, John B [ORNL; Goulding, Richard Howell [ORNL; McGinnis, William Dean [ORNL; Bjorholm, Thomas P [ORNL; Rapp, Juergen [ORNL


    In order to determine long term performance of plasma facing components such as diverters and first walls for fusion devices, next generation plasma generators are needed. A Material Plasma Exposure eXperiment (MPEX) has been proposed to address this need through the generation of plasmas in front of the target with electron temperatures of 1-15 eV and electron densities of 1020 to 1021 m-3. Heat fluxes on target diverters could reach 20 MW/m2. In order generate this plasma, a unique radio frequency helicon source and heating of electrons and ions through Electron Bernstein Wave (EBW) and Ion Cyclotron Resonance Heating (ICRH) has been proposed. MPEX requires a series of magnets with non-uniform central fields up to 2 T over a 5m length in the heating and transport region and 1 T uniform central field over a 1-m length on a diameter of 1.3 m. Given the field requirements, superconducting magnets are under consideration for MPEX. In order to determine the best construction method for the magnets, the cryogenic refrigeration has been analyzed with respect to cooldown and operational performance criteria for open-cycle and closed-cycle systems, capital and operating costs of these system, and maturity of supporting technology such as cryocoolers. These systems will be compared within the context of commercially available magnet constructions to determine the most economical method for MPEX operation. The current state of the MPEX magnet design including details on possible superconducting magnet configurations will be presented.

  18. 75 FR 52860 - Final Airworthiness Design Standards for Acceptance Under the Primary Category Rule; Orlando...


    ... Under the Primary Category Rule; Orlando Helicopter Airways (OHA), Inc., Models Cessna 172I, 172K, 172L... Proposed Airworthiness Design Standards for Acceptance Under the Primary Category Rule; Orlando...

  19. Modified Anchor Shaped Post Core Design for Primary Anterior Teeth

    R. Rajesh; Kusai Baroudi; K. Bala Kasi Reddy; Praveen, B. H.; V. Sumanth Kumar; Amit, S


    Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  20. Modified Anchor Shaped Post Core Design for Primary Anterior Teeth

    R. Rajesh


    Full Text Available Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  1. Modified anchor shaped post core design for primary anterior teeth.

    Rajesh, R; Baroudi, Kusai; Reddy, K Bala Kasi; Praveen, B H; Kumar, V Sumanth; Amit, S


    Restoring severely damaged primary anterior teeth is challenging to pedodontist. Many materials are tried as a post core but each one of them has its own drawbacks. This a case report describing a technique to restore severely damaged primary anterior teeth with a modified anchor shaped post. This technique is not only simple and inexpensive but also produces better retention.

  2. 78 FR 69690 - Draft Guidance for Industry: Considerations for the Design of Early-Phase Clinical Trials of...


    ...The Food and Drug Administration (FDA) is extending the comment period for the draft guidance for industry entitled ``Guidance for Industry: Considerations for the Design of Early-Phase Clinical Trials of Cellular and Gene Therapy Products'' that appeared in the Federal Register of July 2, 2013 (78 FR 39736). The draft guidance document provides sponsors of Investigational New Drug......

  3. Design considerations for a large-scale image-based text search engine in historical manuscript collections

    Schomaker, Lambertus


    This article gives an overview of design considerations for a handwriting search engine based on pattern recognition and high-performance computing, “Monk”. In order to satisfy multiple and often conflicting technological requirements, an architecture is used which heavily relies on high-performance

  4. Soft error rate simulation and initial design considerations of neutron intercepting silicon chip (NISC)

    Celik, Cihangir

    -scale technologies. Prevention of SEEs has been studied and applied in the semiconductor industry by including radiation protection precautions in the system architecture or by using corrective algorithms in the system operation. Decreasing 10B content (20%of natural boron) in the natural boron of Borophosphosilicate glass (BPSG) layers that are conventionally used in the fabrication of semiconductor devices was one of the major radiation protection approaches for the system architecture. Neutron interaction in the BPSG layer was the origin of the SEEs because of the 10B (n,alpha) 7Li reaction products. Both of the particles produced have the capability of ionization in the silicon substrate region, whose thickness is comparable to the ranges of these particles. Using the soft error phenomenon in exactly the opposite manner of the semiconductor industry can provide a new neutron detection system based on the SERs in the semiconductor memories. By investigating the soft error mechanisms in the available semiconductor memories and enhancing the soft error occurrences in these devices, one can convert all memory using intelligent systems into portable, power efficient, directiondependent neutron detectors. The Neutron Intercepting Silicon Chip (NISC) project aims to achieve this goal by introducing 10B-enriched BPSG layers to the semiconductor memory architectures. This research addresses the development of a simulation tool, the NISC Soft Error Analysis Tool (NISCSAT), for soft error modeling and analysis in the semiconductor memories to provide basic design considerations for the NISC. NISCSAT performs particle transport and calculates the soft error probabilities, or SER, depending on energy depositions of the particles in a given memory node model of the NISC. Soft error measurements were performed with commercially available, off-the-shelf semiconductor memories and microprocessors to observe soft error variations with the neutron flux and memory supply voltage. Measurement

  5. Architectural considerations in the design of a superconducting quantum annealing processor

    Bunyk, P. I.; Hoskinson, E.; Johnson, M. W.; Tolkacheva, E.; Altomare, F.; Berkley, A. J.; Harris, R; Hilton, J. P.; Lanting, T.; Whittaker, J


    We have developed a quantum annealing processor, based on an array of tunably coupled rf-SQUID flux qubits, fabricated in a superconducting integrated circuit process [1]. Implementing this type of processor at a scale of 512 qubits and 1472 programmable inter-qubit couplers and operating at ~ 20 mK has required attention to a number of considerations that one may ignore at the smaller scale of a few dozen or so devices. Here we discuss some of these considerations, and the delicate balance n...

  6. Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 22. Nuclear considerations for repository design


    This volume, Y/OWI/TM-36/22, ''Nuclear Considerations for Repository Design,'' is one of a 23-volume series, ''Technical Support for GEIS: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-36, which supplements the ''Contribution to Draft Generic Environmental Impact Statement on Commercial Waste Management: Radioactive Waste Isolation in Geologic Formations,'' Y/OWI/TM-44. The series provides a more complete technical basis for the preconceptual designs, resource requirements, and environmental source terms associated with isolating commercial LWR wastes in underground repositories in salt, granite, shale and basalt. Wastes are considered from three fuel cycles: uranium and plutonium recycling, no recycling of spent fuel and uranium-only recycling. Included in this volume are baseline design considerations such as characteristics of canisters, drums, casks, overpacks, and shipping containers; maximum allowable and actual decay-heat levels; and canister radiation levels. Other topics include safeguard and protection considerations; occupational radiation exposure including ALARA programs; shielding of canisters, transporters and forklift trucks; monitoring considerations; mine water treatment; canister integrity; and criticality calculations.

  7. Future Directions in Adventure-based Therapy Research: Methodological Considerations and Design Suggestions.

    Newes, Sandra L.


    More methodologically sound research in adventure therapy is needed if the field is to claim empirically-based efficacy as a treatment modality. Some considerations for conducting outcome studies in adventure therapy relate to standardization, multiple domain assessment, regression techniques, objective assessment of participant change, client and…

  8. A Visual Haptic System for Children with Learning Disabilities: Software and Hardware Design Considerations

    Subrahmaniyan, Neeraja; Krishnaswamy, Swetha; Chowriappa, Ashirwad; Srimathveeravalli, Govindarajan; Bisantz, Ann; Shriber, Linda; Kesavadas, Thenkurussi


    Research has shown that children with learning disabilities exhibit considerable challenges with visual motor integration. While there are specialized Occupational Therapy interventions aimed at visual motor integration, computer games and virtual toys have now become increasingly popular, forming an integral part of children's learning and play.…

  9. A Course on Operational Considerations in Wastewater Treatment Plant Design. Student Manual.

    Stottler, Stag and Associates, San Antonio, TX.

    This manual was designed to furnish information for upgrading the design of wastewater treatment plant facilities and to serve as a resource for establishing criteria for upgrading these plants. The manual also furnishes information for modifying plant design to compensate for current organic and hydraulic overloads and/or to meet more stringent…

  10. A Study on Primary School English Homework Design



    In the current English environment is lacking and primary school English class is relatively insufficient, homework, which is an easy way to overlook the class and a summary of knowledge of the class and allows students to discover their own learning deficiencies, is an assistant measure that is very useful for class teaching.

  11. Cyclone-Resistant Rural Primary School Construction - A Design Guide. Educational Building Report 7.

    Sinnamon, Ian T.; Loo, G. A. van't

    One of a series of documents on design of disaster-resistant buildings, this publication treats construction of rural primary schools to resist destruction by wind and water from cyclones. Also appropriate for other buildings, material is aimed at rural primary schools because they are less likely to be professionally designed or supervised; the…

  12. 30 CFR 285.707 - What are the CVA's primary duties for facility design review?


    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the CVA's primary duties for facility... Facility Design, Fabrication, and Installation Certified Verification Agent § 285.707 What are the CVA's primary duties for facility design review? If you are required to use a CVA: (a) The CVA must use good...

  13. Cyclone-Resistant Rural Primary School Construction - A Design Guide. Educational Building Report 7.

    Sinnamon, Ian T.; Loo, G. A. van't

    One of a series of documents on design of disaster-resistant buildings, this publication treats construction of rural primary schools to resist destruction by wind and water from cyclones. Also appropriate for other buildings, material is aimed at rural primary schools because they are less likely to be professionally designed or supervised; the…

  14. Important considerations for designing and reporting epidemiologic and clinical studies in dental traumatology

    Andersson, Lars; Andreasen, Jens O


    The purpose of this article is to suggest important considerations for epidemiologic and clinical studies in the field of dental traumatology. The article is based on the authors' experiences from research in this field and editorial board work for the scientific journal Dental Traumatology....... Examples are given of issues where development is important. The importance of planning ahead of the study and consulting with experts in other fields is emphasized....

  15. Design Considerations of Help Options in Computer-Based L2 Listening Materials Informed by Participatory Design

    Cárdenas-Claros, Mónica Stella


    This paper reports on the findings of two qualitative exploratory studies that sought to investigate design features of help options in computer-based L2 listening materials. Informed by principles of participatory design, language learners, software designers, language teachers, and a computer programmer worked collaboratively in a series of…

  16. Design Considerations of Help Options in Computer-Based L2 Listening Materials Informed by Participatory Design

    Cárdenas-Claros, Mónica Stella


    This paper reports on the findings of two qualitative exploratory studies that sought to investigate design features of help options in computer-based L2 listening materials. Informed by principles of participatory design, language learners, software designers, language teachers, and a computer programmer worked collaboratively in a series of…

  17. Primary Teachers' and Students' Understanding of School Situated Design in Canada and England

    Hill, Ann Marie; Anning, Angela


    How do teachers in primary schools translate curriculum requirements for teaching design, within technology frameworks, in their primary classrooms? We call teachers' and students' designerly thinking and behaviours school situated design. The results discussed in this paper are part of a larger study that explored: the relationships between designerly thinking and behaviours situated in primary/elementary classrooms in Ontario (Canada) and England (UK); beliefs about how designing is learned in schools and how they compare to learning and designing in the real world and children's and teachers' understanding of design. Data were collected from teachers, children and designers through interviews, classroom observations and dialogue, photographs and design documents. This paper focuses on the school situated design evidence from the study - the teacher and student data - and refers only briefly to designer data to compare school activities to workplace design. We call professional designers' designerly thinking and behaviours workplace design. Similarities and differences between primary school situated design in Ontario (Canada) and England (UK) are discussed.

  18. [What a primary health care is: some considerations after almost thirty five years of Alma-Ata].

    Tejada de Rivero, David A


    Primary health care was conceived in the 70s as a comprehensive, joint and inclusive strategy to achieve the goal of "Health for Everyone". It was the result of important social, political and economic changes which occurred at global level back in those years and which persist until now. Due to an unfortunate combination of words, Primary Healthcare has been mistakenly understood by many as "healthcare at the basic level" or the "provision of basic, and hence insufficient services to the poorest", wrong concepts that contribute to the current social and health inequalities. This article explains what primary healthcare is and what it is not in order to address the subject in its real context.

  19. (U) Design Considerations for Obtaining Deep Release in Reacted Epon 828

    Fredenburg, David A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Lang, John Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Dattelbaum, Dana Mcgraw [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bennett, Langdon Stanford [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    Our document summarizes results from one-dimensional calculations performed to investigate the release behavior of reacted Epon 828. Two design goals were set, (1) the product phase had to be achieved upon the initial shock loading, and (2) a deep release state could be achieved. Both transmission and front surface impact geometry were investigated. Moreover, the two design criteria were met with the front surface impact design employing a modi ed projectile.

  20. Reliability considerations in long-life outer planet spacecraft system design

    Casani, E. K.


    A Mariner Jupiter/Saturn mission has been planned for 1977. System reliability questions are discussed, taking into account the actual and design lifetime, causes of mission termination, in-flight failures and their consequences for the mission, and the use of redundancy to avoid failures. The design process employed optimizes the use of proven subsystem and system designs and then makes the necessary improvements to increase the lifetime as required.

  1. Human Centred Design Considerations for Connected Health Devices for the Older Adult

    Richard P. Harte


    Full Text Available Connected health devices are generally designed for unsupervised use, by non-healthcare professionals, facilitating independent control of the individuals own healthcare. Older adults are major users of such devices and are a population significantly increasing in size. This group presents challenges due to the wide spectrum of capabilities and attitudes towards technology. The fit between capabilities of the user and demands of the device can be optimised in a process called Human Centred Design. Here we review examples of some connected health devices chosen by random selection, assess older adult known capabilities and attitudes and finally make analytical recommendations for design approaches and design specifications.

  2. Design considerations and initial physical layer performance results for a space time coded OFDM 4G cellular network

    Doufexi, A; Armour, SMD; Nix, AR; Beach, MA


    The exponential growth of cellular radio, WLANs and the Internet sets the context for a discussion on the role and objectives of 4G. In this paper OFDM is proposed as a leading candidate for a 4G cellular communications standard. The key design considerations and link parameters for a 4G OFDM system are identified and initial physical layer performance results are presented for a number of transmission modes and channel scenarios. Additionally, space-time techniques are considered as a means ...

  3. Abrams Primary School passive solar design. Phase 1. Final report



    The general project documentation and the design process documentation for the project are presented. The following are appended: analysis of thermal transfer and internal heat contributions to the heating and cooling loads for a typical four-classroom teaching module using bin-chart temperature data, trace simulation for the original building design, Teanet simulation of original building design for the month of January 1959, Teanet simulation of Solar 2 for the month of January 1959, incremental solar cost assessment, and diffuse radiation incident on the monitor glass. (MHR)

  4. Injector Cavities Fabrication, Vertical Test Performance and Primary Cryomodule Design

    Wang, Haipeng [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Cheng, Guangfeng [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Clemens, William [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Davis, G [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Macha, Kurt [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Overton, Roland [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Spell, D. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)


    After the electromagnetic design and the mechanical design of a β=0.6, 2-cell elliptical SRF cavity, the cavity has been fabricated. Then both 2-cell and 7-cell cavities have been bench tuned to the target values of frequency, coupling external Q and field flatness. After buffer chemistry polishing (BCP) and high pressure rinses (HPR), Vertical 2K cavity test results have been satisfied the specifications and ready for the string assembly. We will report the cavity performance including Lorenz Force Detuning (LFD) and Higher Order Modes (HOM) damping data. Its integration with cavity tuners to the cryomodule design will be reported.

  5. Design considerations for MIL-STD-2179 recorders in a rugged environment

    Hoff, Steve C.


    MIL-STD-2179 is based on D-1 technology which has been proven in the commercial TV industry for over ten years. Application of this technology, in a harsh military environment, has presented technical challenges not addressed in commercial designs. This paper addresses those special design obstacles as well as enhancements desirable for scientific data manipulation compared to fixed rate benign commercial applications.

  6. A Course on Operational Considerations in Wastewater Treatment Plant Design. Instructor's Manual.

    Cooper, John W.; And Others

    This manual contains 17 instructional units (sequenced to correspond to parallel chapters in a student's manual) focusing on upgrading the design of wastewater plant facilities and serving as a reference source for establishing criteria for upgrading wastewater treatment plants. The manual also furnishes information for modifying plant design to…

  7. Magnetic design consideration of a Magnetic Lead Screw with Halbach Array

    Holm, Rasmus Koldborg; Berg, Nick Ilsø; Rasmussen, Peter Omand

    This paper presents the novel design of a Magnetic Lead Screw (MLS) with magnetic thread of Halbach Arrays. The MLS where designed and build, tests indicated a stall force which where 12 % lower than calculated in 3D FE. This is explained by demagnetization of the magnet during stall, the behavio...

  8. Design Considerations of Fast Kicker Systems for High Intensity Proton Accelerators

    Zhang, W; Sandberg, J; Parson, W M; Walstrom, P; Murray, M M; Cook, E; Hartouni, E


    In this paper, we discuss the specific issues related to the design of the Fast Kicker Systems for high intensity proton accelerators. To address these issues in the preliminary design stage can be critical since the fast kicker systems affect the machine lattice structure and overall design parameters. Main topics include system architecture, design strategy, beam current coupling, grounding, end user cost vs. system cost, reliability, redundancy and flexibility. Operating experience with the Alternating Gradient Synchrotron injection and extraction kicker systems at Brookhaven National Laboratory and their future upgrade is presented. Additionally, new conceptual designs of the extraction kicker for the Spallation Neutron Source at Oak Ridge and the Advanced Hydrotest Facility at Los Alamos are discussed.

  9. Design considerations of electromagnetic force in a direct drive permanent magnet brushless motor

    Chen, H. S.; Tsai, M. C.


    In this paper, a numerical study of electromagnetic force associated with the width of stator teeth, width of rotor back iron, and slot opening for a ten-pole nine-slot direct drive permanent magnet brushless motor is presented. The study calculates the amplitude of the electromagnetic force on the rotating rotor by using the finite-element method. The results show that the amplitude of electromagnetic force, which may cause the noise and vibration of motors, changes with the variation of these above mentioned three factors. The relationship between the considerations of output torque and the minimization of noise and vibration is also established in this paper.

  10. Decision Optimization of Machine Sets Taking Into Consideration Logical Tree Minimization of Design Guidelines

    Deptuła A.


    Full Text Available The method of minimization of complex partial multi-valued logical functions determines the degree of importance of construction and exploitation parameters playing the role of logical decision variables. Logical functions are taken into consideration in the issues of modelling machine sets. In multi-valued logical functions with weighting products, it is possible to use a modified Quine - McCluskey algorithm of multi-valued functions minimization. Taking into account weighting coefficients in the logical tree minimization reflects a physical model of the object being analysed much better

  11. Design considerations in the use of stainless steel for vacuum and cryogenic equipment

    Geyari, C


    The properties making austenitic stainless steel a preferred material for the construction of high vacuum equipment are reviewed. Best results are obtained if attention is paid to the improvement of welding properties, particularly with a view to prevent intercrystalline disintegration. A review of mechanical properties, the effect of cold working and cryogenic temperatures on the strength and magnetic characteristics of stainless steel is given. During material selection for very high vacuum, attention must be paid to the porosity problem. A practical example shows the application of these considerations to the choice of materials for the CERN-ISR intersecting storage rings. (19 refs).

  12. Structural Design Considerations for Tubular Power Tower Receivers Operating at 650 Degrees C: Preprint

    Neises, T. W.; Wagner, M. J.; Gray, A. K.


    Research of advanced power cycles has shown supercritical carbon dioxide power cycles may have thermal efficiency benefits relative to steam cycles at temperatures around 500 - 700 degrees C. To realize these benefits for CSP, it is necessary to increase the maximum outlet temperature of current tower designs. Research at NREL is investigating a concept that uses high-pressure supercritical carbon dioxide as the heat transfer fluid to achieve a 650 degrees C receiver outlet temperature. At these operating conditions, creep becomes an important factor in the design of a tubular receiver and contemporary design assumptions for both solar and traditional boiler applications must be revisited and revised. This paper discusses lessons learned for high-pressure, high-temperature tubular receiver design. An analysis of a simplified receiver tube is discussed, and the results show the limiting stress mechanisms in the tube and the impact on the maximum allowable flux as design parameters vary. Results of this preliminary analysis indicate an underlying trade-off between tube thickness and the maximum allowable flux on the tube. Future work will expand the scope of design variables considered and attempt to optimize the design based on cost and performance metrics.

  13. Interface design and human factors considerations for model-based tight glycemic control in critical care.

    Ward, Logan; Steel, James; Le Compte, Aaron; Evans, Alicia; Tan, Chia-Siong; Penning, Sophie; Shaw, Geoffrey M; Desaive, Thomas; Chase, J Geoffrey


    Tight glycemic control (TGC) has shown benefits but has been difficult to implement. Model-based methods and computerized protocols offer the opportunity to improve TGC quality and compliance. This research presents an interface design to maximize compliance, minimize real and perceived clinical effort, and minimize error based on simple human factors and end user input. The graphical user interface (GUI) design is presented by construction based on a series of simple, short design criteria based on fundamental human factors engineering and includes the use of user feedback and focus groups comprising nursing staff at Christchurch Hospital. The overall design maximizes ease of use and minimizes (unnecessary) interaction and use. It is coupled to a protocol that allows nurse staff to select measurement intervals and thus self-manage workload. The overall GUI design is presented and requires only one data entry point per intervention cycle. The design and main interface are heavily focused on the nurse end users who are the predominant users, while additional detailed and longitudinal data, which are of interest to doctors guiding overall patient care, are available via tabs. This dichotomy of needs and interests based on the end user's immediate focus and goals shows how interfaces must adapt to offer different information to multiple types of users. The interface is designed to minimize real and perceived clinical effort, and ongoing pilot trials have reported high levels of acceptance. The overall design principles, approach, and testing methods are based on fundamental human factors principles designed to reduce user effort and error and are readily generalizable. © 2012 Diabetes Technology Society.

  14. First Considerations on Beam Optics and Lattice Design for the Future Hadron-Hadron Collider FCC

    Alemany Fernandez, R


    The present document explains the steps carried out in order to make the first design of the Future Hadron-Hadron Collider (FCC-hh) following the base line parameters that can be found in [1]. Two lattice layouts are presented, a ring collider with 12 arcs and 12 straight sections, four of them designed as interaction points, and a racetrack like collider with two arcs and two straight sections, each of them equipped with two interaction points. The lattice design presented in the paper is modular allowing the same modules be used for both layouts. The present document addresses as well the beta star reach at the interaction points.

  15. Design considerations and performance characteristics of high concentration point-focussing photovoltaic modules

    Sanders, J.A.; Broadbent, S.


    Through the auspices of the Department of Energy, the Fresnel lens point-focussing photovoltaic module has evolved into a commercially available, high efficiency low cost option for converting solar energy into electricity. The 15.4% efficient baseline module is undergoing several design improvements to achieve higher efficiencies at high concentrations and lower cost. A 16.5% module will be available in 1984 and 18% Gallium Arsenide modules in 1985. This paper describes the design details and performance characteristics of the baseline module and the design improvements.

  16. Natural laminar flow airfoil design considerations for winglets on low-speed airplanes

    Vandam, C. P.


    Winglet airfoil section characteristics which significantly influence cruise performance and handling qualities of an airplane are discussed. A good winglet design requires an airfoil section with a low cruise drag coefficient, a high maximum lift coefficient, and a gradual and steady movement of the boundary layer transition location with angle of attack. The first design requirement provides a low crossover lift coefficient of airplane drag polars with winglets off and on. The other requirements prevent nonlinear changes in airplane lateral/directional stability and control characteristics. These requirements are considered in the design of a natural laminar flow airfoil section for winglet applications and chord Reynolds number of 1 to 4 million.

  17. Simplicity in command and control systems - A human factors consideration. [for man computer interfare design

    Chafin, R. L.


    The importance of simplicity in the man computer interface (MCI) is stressed because of the effect it has on the system containing the MCI. Results are used from an MCI study at the Jet Propulsion Laboratory to find an area where the system MCIs can be simplified. The circumstances under which these simplifications are appropriate are listed. The concepts of cognitive simplicity and process simplicity are presented as design alternatives for the MCI. In addition, the concepts of understandability, operation, learnability, level of learning, and usability are presented as tools for the system designer. The use of these concepts in developing a systematic MCI design is discussed.

  18. FMEA and consideration of real work situations for safer design of production systems.

    Lux, Aurélien; Mawo De Bikond, Johann; Etienne, Alain; Quillerou-Grivot, Edwige


    Production equipment designers must ensure the health and safety of future users; in this regard, they augment requirements for standardizing and controlling operator work. This contrasts with the ergonomic view of the activity, which recommends leaving operators leeway (margins for manoeuvre) in performing their task, while safeguarding their health. Following a brief analysis of design practices in the car industry, we detail how the Failure Modes and Effects Analysis (FMEA) approach is implemented in this sector. We then suggest an adaptation that enables designers to consider real work situations. This new protocol, namely, work situation FMEA, allows experience feedback to be used to defend the health standpoint during designer project reviews, which usually only address quality and performance issues. We subsequently illustrate the advantage of this approach using two examples of work situations at car parts manufacturers: the first from the literature and the second from an in-company industrial project.

  19. Design Consideration of SAW/BAW Band Reject Filters Embedded in Impedance Converter.

    Huang, Yulin; Bao, Jingfu; Tang, Gongbin; Zhang, Qiaozhen; Omori, Tatsuya; Hashimoto, Ken-Ya


    This paper discusses design of surface acoustic wave/bulk acoustic wave (SAW/BAW)-based band reject filters composed of the impedance converters, where capacitive elements are replaced with SAW/BAW resonators. First, basic properties of the unit cell are studied. It is shown how basic properties of a unit cell change with the design. It is also shown that when two notches caused by the resonators are placed in proximity, two synergy effects occur: 1) an extra matching point appears on one side of the transition band. This makes the insertion loss at the point smaller and the transition band steeper and 2) the dip level becomes deeper, and the total rejection level improves. Then, two resonators are fabricated, measured, and combined with inductors in circuit simulator to demonstrate functionality of the basic cell design. Finally, the wide rejection band filter is designed by cascading multistages, and effectiveness of the device configurations is demonstrated.

  20. Design considerations for the beam-waveguide retrofit of a ground antenna station

    Veruttipong, T.; Withington, J.; Galindo-Israel, V.; Imbriale, W.; Bathker, D.


    Retrofitting an antenna that was originally designed without a beam waveguide introduces special difficulties because it is desirable to minimize alteration of the original mechanical truss work and to image the actual feed without distortion at the focal point of the dual-shaped reflector. To obtain an acceptable image, certain Geometrical Optics (GO) design criteria are followed as closely as possible. The problems associated with applying these design criteria to a 34-meter dual-shaped DSN (Deep Space Network) antenna are discussed. The use of various diffraction analysis techniques in the design process is also discussed. GTD and FFT algorithms are particularly necessary at the higher frequencies, while Physical Optics and Spherical Wave Expansions proved necessary at the lower frequencies.

  1. Design considerations to enhance the safety of patient compartments in ambulance transporters.

    Byran, Eyal; Gilad, Issachar


    The safety of the interior of ambulances is dubious and, in the event of sudden impact during emergency transport, potentially perilous to patients they carry. The workplace ergonomics of the interior of the passenger cabin is lacking. This article discusses an improved ergonomic interior design based on study findings, observations and subjective perception. It suggests design aspects and safety concepts aimed at increasing the safety of patients and paramedic staff inside the ambulance as a mobile workstation.

  2. Lightweight design and finite element analysis of primary mirror for the space telescope

    Zhang, Dandan; Li, Weiyan; Lv, Qunbo; Liu, Yangyang; Chen, Xinwen


    In order to satisfy the strict requirements of the lightweight ratios and high dimensional stability for space mirror, the design method of lightweight structure and the flexible supporting structure of the primary mirror is proposed. Subsequently, the surface deformations of two different lightweight structures for primary mirror are discussed for analyzing the influence of the mirror weight on its surface. Finally, the finite element models for primary mirror assembly are built for calculating the surface deformation caused by different gravity orientations and various thermal environments. It is proved that the weight, stiffness and surface accuracy of the structure design for primary mirror can meet the engineering requirement.

  3. Thermo-mechanical Design Considerations for First Wall of A-SSTR2

    何开辉; 西尾敏


    The finite element analysis and calculation were performed for the blanket first-wallmade of SiC/SiC composite material for Advanced Steady-state Tokamak Reactor 2, A-SSTR2,which at present is conceptually designed in Naka Fusion research establishment, JAERI. Compar-ison analysis and design window were analyzed using the finite element code ADINA 7.4. Througha 2D calculation for various geometrical configurations and sensitive material properties, a fun-damental guideline for the first wall and blanket design are established with respect to maximumtemperature, thermal and mechanical stress for many configurations. To satisfy hydrodynamicrequirement, a4d4 (the dimension of coolant channel is 4 mm × 8 mm, and the distance betweenneighboring channels is 4 mm) was chosen as a design point for high thermal conductivity upto 50 W/m.K. In order to find a good solution for lower conductivity, more elaborate work shouldbe done in the future. Nonetheless, the outline of design window for a specific structural materialis very useful for the future A-SSTR2 first wall design.

  4. Design and Analysis Considerations for Cluster Randomized Controlled Trials That Have a Small Number of Clusters.

    Deke, John


    Cluster randomized controlled trials (CRCTs) often require a large number of clusters in order to detect small effects with high probability. However, there are contexts where it may be possible to design a CRCT with a much smaller number of clusters (10 or fewer) and still detect meaningful effects. The objective is to offer recommendations for best practices in design and analysis for small CRCTs. I use simulations to examine alternative design and analysis approaches. Specifically, I examine (1) which analytic approaches control Type I errors at the desired rate, (2) which design and analytic approaches yield the most power, (3) what is the design effect of spurious correlations, and (4) examples of specific scenarios under which impacts of different sizes can be detected with high probability. I find that (1) mixed effects modeling and using Ordinary Least Squares (OLS) on data aggregated to the cluster level both control the Type I error rate, (2) randomization within blocks is always recommended, but how best to account for blocking through covariate adjustment depends on whether the precision gains offset the degrees of freedom loss, (3) power calculations can be accurate when design effects from small sample, spurious correlations are taken into account, and (4) it is very difficult to detect small effects with just four clusters, but with six or more clusters, there are realistic circumstances under which small effects can be detected with high probability. © The Author(s) 2016.

  5. Primary diffuse large B-cell lymphoma of the prostate: A report of two cases with diagnostic considerations

    Aanchal Kakkar


    Full Text Available Primary prostatic lymphomas are extremely unusual neoplasms. Their rarity and nonspecific symptomatology at presentation usually prompt a clinical diagnosis of benign prostatic hyperplasia or chronic prostatitis, leading to significant delay in diagnosis. Clinical examination, serum prostate-specific antigen levels, and transrectal ultrasonography (TRUS are not of much utility in differential diagnosis, and histological examination is the gold standard. We report two cases of primary non-Hodgkin lymphoma of prostate, diffuse large B-cell type, diagnosed on TRUS-guided prostatic biopsies. Correct diagnosis is of crucial importance as the therapeutic strategy for lymphoma is radically different from that for carcinoma, and early detection of prostatic lymphoma can be potentially curative. Thus, knowledge of this rare entity, inclusion in differential diagnosis of lower urinary tract obstruction, and application of an appropriate immunohistochemical panel are essential so as not to miss this unusual diagnosis and to avoid unnecessary surgery.

  6. Human factors considerations in designing for infection prevention and control in neonatal care - findings from a pre-design inquiry.

    Trudel, Chantal; Cobb, Sue; Momtahan, Kathryn; Brintnell, Janet; Mitchell, Ann


    Qualitative data collection methods drawn from the early stages of human-centred design frameworks combined with thematic analysis were used to develop an understanding of infection prevention practice within an existing neonatal intensive care unit. Findings were used to generate a framework of understanding which in turn helped inform a baseline approach for future research and design development. The study revealed that a lack of clarity between infection transmission zones and a lack of design attributes needed to uphold infection prevention measures may be undermining healthcare workers' understanding and application of good practice. The issue may be further complicated by well-intentioned behavioural attitudes to meeting work objectives; undue influences from spatial constraints; the influence of inadvertent and excessive touch-based interactions; physical and/or cognitive exertion to maintain transmission barriers; and the impact of expanding job design and increased workload to supplement for lack of effective barriers. Practitioner Summary: Despite high hand hygiene compliance within a neonatal intensive care unit, healthcare workers expressed concerns about the unit design and infection prevention practice. Early inquiry methods from human-centred design and thematic analysis helped develop a framework to understand how design can be used to aid infection prevention.

  7. Design Considerations for Exterior and Interior Configurations of Surface Habitat Modules

    Bannova, O.

    Planning for long-duration lunar and Mars exploration missions must provide appropriate human support accommodations to optimize crew comfort, health, morale, performance and safety. Important requirements to make planetary exploration missions successful are to create habitats and facilities offering the maximum possible space and volume for human and mission needs, minimize site preparation and module assembly time and offer on-site equipment readiness in the fewest number of launches. The paper addresses two general types of habitat structures: vertical and horizontal. Both of these approaches offer special advantages, but also impose special planning considerations to optimize benefits. Goals are to maximize habitability, crew safety, spatial efficiency, functional versatility and EVA access/egress from the surface. While complying with the strictly constrained diameter and length dimensions imposed by Earth launch vehicles, landing limitations and surface mobility restrictions. Illustrative concepts are presented showing examples of interior layouts, functional areas and equipment systems.

  8. Towards Improved Considerations of Risk in Seismic Design (Plinius Medal Lecture)

    Sullivan, T. J.


    The aftermath of recent earthquakes is a reminder that seismic risk is a very relevant issue for our communities. Implicit within the seismic design standards currently in place around the world is that minimum acceptable levels of seismic risk will be ensured through design in accordance with the codes. All the same, none of the design standards specify what the minimum acceptable level of seismic risk actually is. Instead, a series of deterministic limit states are set which engineers then demonstrate are satisfied for their structure, typically through the use of elastic dynamic analyses adjusted to account for non-linear response using a set of empirical correction factors. From the early nineties the seismic engineering community has begun to recognise numerous fundamental shortcomings with such seismic design procedures in modern codes. Deficiencies include the use of elastic dynamic analysis for the prediction of inelastic force distributions, the assignment of uniform behaviour factors for structural typologies irrespective of the structural proportions and expected deformation demands, and the assumption that hysteretic properties of a structure do not affect the seismic displacement demands, amongst other things. In light of this a number of possibilities have emerged for improved control of risk through seismic design, with several innovative displacement-based seismic design methods now well developed. For a specific seismic design intensity, such methods provide a more rational means of controlling the response of a structure to satisfy performance limit states. While the development of such methodologies does mark a significant step forward for the control of seismic risk, they do not, on their own, identify the seismic risk of a newly designed structure. In the U.S. a rather elaborate performance-based earthquake engineering (PBEE) framework is under development, with the aim of providing seismic loss estimates for new buildings. The PBEE framework

  9. The Impact of Materials and Maintenance Considerations during the Design Stage of Public Buildings in Oman

    Al Rubaiey S.


    Full Text Available The purpose of this study is to describe the experiences of architects and civil engineers in the Sultanate of Oman regarding building maintenance during the design of public buildings. This exploratory and descriptive study used a qualitative approach, drawing data from focus groups in particular, to develop a rich and in-depth description of the designers’ building maintenance experiences. Structured interviews were conducted with 15 participants from architecture and civil engineering fields, from which, the interviewees shared the viewpoint that maintenance functions entirely separate from the design and construction process itself, but that it is, in fact, an integral part of the design process and post-occupancy stage. The designer should plan for sufficient maintenance for the whole building life cycle. However, some elements are more difficult to maintain in Oman than in other regions such as roofs, facades and the substructure of buildings. The results showed that salt is the most challenging environmental factor that could cause building defects. This was followed by solar heat, moisture from below ground and, lastly, rain. Most of these defects occurred during the buildings’ post-occupancy phase and were related to inappropriate or poor design. The results also suggested that deficiencies caused by thermal expansion came in the form of cracks, followed by paint decay, dampness, and staining.

  10. Design Considerations of a Slit Diaphragm Flexure Used in a Precision Mirror Gimbal

    Cox, B. C., Kaufman, M. I.


    Two precision mirror gimbals were designed using slit diaphragm flexures to provide two-axis precision mirror alignment in space-limited applications. Both gimbals are currently in use in diagnostics at the National Ignition Facility: one design in the Gamma Reaction History (GRH) diagnostic and the other in the Neutron Imaging System (NIS) diagnostic. The GRH gimbal has an adjustment sensitivity of 0.1 mrad about both axes and a total adjustment capability of ±6°; the NIS gimbal has an adjustment sensitivity of 0.8 μrad about both axes and a total adjustment range of ±3°. Both slit diaphragm flexures were electro-discharge machined out of high-strength titanium and utilize stainless steel stiffeners. The stiffener-flexure design results in adjustment axes with excellent orthogonality and centering with respect to the mirror in a single stage; a typical two-axis gimbal flexure requires two stages. Finite element analyses are presented for both flexure designs, and a design optimization of the GRH flexure is discussed.

  11. Design considerations of a slit diaphragm flexure used in a precision mirror gimbal

    Cox, Brian; Kaufman, Morris


    Two precision mirror gimbals were designed using slit diaphragm flexures to provide two-axis precision mirror alignment in space-limited applications. Both gimbals are currently in use in diagnostics at the National Ignition Facility: one design in the Gamma Reaction History (GRH) diagnostic and the other in the Neutron Imaging System (NIS) diagnostic. The GRH gimbal has an adjustment sensitivity of 0.1 mrad about both axes and a total adjustment capability of +/-6° the NIS gimbal has an adjustment sensitivity of 0.8 μrad about both axes and a total adjustment range of +/-3°. Both slit diaphragm flexures were electro-discharge machined out of high-strength titanium and utilize stainless steel stiffeners. The stiffener-flexure design results in adjustment axes with excellent orthogonality and centering with respect to the mirror in a single stage; a typical two-axis gimbal flexure requires two stages. Finite element analyses are presented for both flexure designs, and a design optimization of the GRH flexure is discussed.

  12. Design Considerations for Wireless Charging Systems with an Analysis of Batteries

    Zhenshi Wang


    Full Text Available Three criteria, including charging time, effective charging capacity and charging energy efficiency, are introduced to evaluate the CC (constant current and CC/CV (constant current/constant voltage charging strategies. Because the CC strategy presents a better performance and most resonant topologies have the CC characteristic, the CC strategy is more suitable for the design of wireless charging systems than the CC/CV strategy. Then, the state space model of the receiver is built to study the system dynamic characteristics, and the design of nonuse output filter capacitors is proposed, which can improve the system power density and avoid the drop in efficiency caused by capacitor degradation. At last, an electrochemical impedance spectrum (EIS based analysis method is introduced to validate that the design without output filter capacitors has no effects on the battery characteristics when the charging frequency is higher than 460 Hz. A prototype is fabricated to verify our research results.

  13. Thermodynamic considerations for the design of a sonic-boom reducing powerplant.

    Galanis, N.


    Third-order analytical expressions are obtained for the lift and wave-drag coefficients of a two-dimensional wing. The expressions are used to demonstrate the possibility of boomless lifting configuration designs when the cross-section area of the stream tube is reduced. The reduction is obtained by processing the captured airstream in such a manner that the stream tube area is smaller at the exit than at the entrance. Calculations by these expressions are shown to be in good agreement with exact results obtained from compressive flow tables. It is also shown that three-dimensional wing configurations of this design give the maximum thermodynamic effect when a propulsive power plant is employed for the reduction of the captured-stream area. Thermodynamic guidelines are given for power plant designs to be used for this purpose.

  14. First Considerations Concerning an Optimized Cavity Design for the Main Linac of BERLinPro

    B. Riemann, T. Weis, W. Anders, J. Knobloch, A. Neumann, H.-W. Glock, C. Potratz, U. van Rienen, F. Marhauser


    The Berlin Energy Recovery Linac Project (BERLinPro) is designed to develop and demonstrate CW linac technology and expertise required to drive next-generation Energy Recovery Linacs. Strongly HOM-damped multicell 1.3 GHz cavities are required for the main linac. The optimization of the cavities presented here is primarily based on the CEBAF 1.5 GHz 5-cell high-current cavity design, including HOM waveguide couplers. The cavity was scaled to 1.3 GHz and extended to 7 cells. Modifications to the end group design have also been studied. An effort was also made to reduce the ratio Epk/Eacc while still permitting HOMs to propagate.

  15. Enviro-geotechnical considerations in waste containment system design and analysis

    Fang, H.Y.; Daniels, J.L.; Inyang, H.I. [Univ. of Massachusetts, Lowell, MA (United States)


    The effectiveness of waste control facilities hinges on careful evaluation of the overall planning, analysis and design of the entire system prior to construction. At present, most work is focused on the waste controlling system itself, with little attention given to the local environmental factors surrounding the facility sites. Containment materials including geomembranes, geotextiles and clay amended soils have received intense scrutiny. This paper, however, focuses on three relatively important issues relating to the characterization of the surrounding geomedia. Leakage through naturally occurring low-permeability soil layers, shrinkages swelling, cracking and effects of dynamic loads on system components are often responsible for a waste containment breach. In this paper, these mechanisms and their synergistic effects are explained in terms of the particle energy field theory. It is hoped that this additional information may assist the designer to be aware or take precaution to design safer future waste control facilities.

  16. A document describing shuttle considerations for the design of large space structures

    Roebuck, J. A., Jr.


    A Shuttle user guide document to aid designers and analysis associated with large space structures projects is described. The format and contents are a compromise designed to satisfy the needs of several levels of users. Special features include checklists and references to source documents as a convenience to very knowledgeable readers. In addition, general, introductory and explanatory text, and art work are included for the reader less familiar with shuttle systems. Also, there are a subject index, glossary, list of acronyms, and many cross references. Throughout the document, there are suggested implications or references to the importance of the included orbiter interfaces material as it pertains to designing and planning large space structures projects. The content of the document is outlined. Shuttle payload accommodations and constraints, connections for orbiter construction fixtures, packaging, and construction space eometry are addressed.

  17. Design factors and considerations for a time-based flight management system

    Vicroy, D. D.; Williams, D. H.; Sorensen, J. A.


    Recent NASA Langley Research Center research to develop a technology data base from which an advanced Flight Management System (FMS) design might evolve is reviewed. In particular, the generation of fixed range cruise/descent reference trajectories which meet predefined end conditions of altitude, speed, and time is addressed. Results on the design and theoretical basis of the trajectory generation algorithm are presented, followed by a brief discussion of a series of studies that are being conducted to determine the accuracy requirements of the aircraft and weather models resident in the trajectory generation algorithm. Finally, studies to investigate the interface requirements between the pilot and an advanced FMS are considered.

  18. Electrolyte Management Considerations in Modern Nickel Hydrogen and Nickel Cadmium Cell and Battery Designs

    Thaller, Lawrence H.; Zimmerman, Albert H.


    This paper reviews three general areas where the potassium ion content can impact the performance and life of nickel hydrogen and nickel cadmium cells. Sample calculations of the concentration or volume changes that can take place within operating cells are presented. With the aid of an accurate model of an operating cell or battery, the impact of changes of potassium ion content within a potential cell design can be estimated. All three of these areas are directly related to the volume tolerance and pore size engineering aspects of the components used in the cell or battery design.

  19. Design Considerations for Thermally Insulating Structural Sandwich Panels for Hypersonic Vehicles

    Blosser, Max L.


    Simplified thermal/structural sizing equations were derived for the in-plane loading of a thermally insulating structural sandwich panel. Equations were developed for the strain in the inner and outer face sheets of a sandwich subjected to uniaxial mechanical loads and differences in face sheet temperatures. Simple equations describing situations with no viable solution were developed. Key design parameters, material properties, and design principles are identified. A numerical example illustrates using the equations for a preliminary feasibility assessment of various material combinations and an initial sizing for minimum mass of a sandwich panel.

  20. Design Considerations for Miniaturized Control Moment Gyroscopes for Rapid Retargeting and Precision Pointing of Small Satellites

    Patankar, Kunal; Fitz-Coy, Norman; Roithmayr, Carlos


    This paper presents the design as well as characterization of a practical control moment gyroscope (CMG) based attitude control system (ACS) for small satellites in the 15-20 kg mass range performing rapid retargeting and precision pointing maneuvers. The paper focuses on the approach taken in the design of miniaturized CMGs while considering the constraints imposed by the use of commercial off-the-shelf (COTS) components as well as the size of the satellite. It is shown that a hybrid mode is...

  1. Instructional Design for Computer-Supported Collaborative Learning in Primary and Secondary School.

    Gros, Begona


    Discussion of computer-supported collaborative learning (CSCL) focuses on the way in which current instructional design theories can be used to design collaborative learning environments in primary and secondary schools. Highlights include definitions of CSCL; CSCL research, including cognitive approach, systems design, and curricular…

  2. 78 FR 28896 - Design Limits and Loading Combinations for Metal Primary Reactor Containment System Components


    ... COMMISSION Design Limits and Loading Combinations for Metal Primary Reactor Containment System Components... Regulatory Commission (NRC) is issuing Revision 2 to Regulatory Guide (RG) 1.57, ``Design Limits and Loading... clarity. This guide describes a method that the NRC staff considers acceptable for design limits...

  3. Towards Primary School Physics Teaching and Learning: Design Research Approach. Research Report 256

    Juuti, Kalle


    This thesis describes a project to design a primary school physics learning environment which takes into account teachers' needs, design procedures, properties of the learning environment, and pupil learning outcomes. The project's design team has wide experience in research and development work in relation to science education, the use of ICT in…

  4. Exploring different dimensions of holism: considerations in the context of an evaluation of complementary medicine in primary care.

    Marian, Florica


    Holism is often associated with both complementary medicine and primary care. In the context of the Swiss Programme for the Evaluation of Complementary Medicine (PEK), the concept of holism emerged from data on physician's philosophy of care and motivation for patients' choice of physician. Yet, as PEK primarily aimed to quantify differences between conventional and complementary medicine, qualitative aspects of the study were neglected and data not fully explored. The main objective of this article is to explore the concept, variations and dimensions of holism by exploring and reflecting on PEK results implicitly and explicitly related to holism.

  5. Private financing and operation of a space station: Investment requirements, risk, government support and other primary business management considerations

    Simon, M.


    Private investment in a manned space station is considered as an alternative to complete government sponsorship of such a program. The implications of manned space operations are discussed from a business perspective. The most significant problems and risks which would be faced by a private company involved in a space station enterprise are outlined and possible government roles in helping to overcome these difficulties suggested. Economic factors such as inflation and the rate of interest are of primary concern, but less obvious conditions such as antitrust and appropriate regulatory laws, government appropriations for space activities, and national security are also considered.

  6. A VDF/TrFE copolymer on silicon pyroelectric sensor: design considerations and experiments

    Setiadi, D.; Regtien, P.P.L.


    For an optimal design of a VDF/TrFE (vinylidene fluoride trifluoroethylene) copolymer-on-silicon pyroelectric sensor, the one-dimensional diffusion equation is solved for the pyroelectric multilayer structure. Output current and voltage of the sensor are calculated. Improvement of the sensor can be

  7. Teachers' Attitudes toward Technology: Considerations for Designing Preservice and Practicing Teacher Instruction

    Banas, Jennifer R.


    To best design technological pedagogical content knowledge (TPCK) related instruction for preservice teachers or for practicing teachers, community college librarians must have an accurate assessment of their audience's attitudes towards technology. A summary, analysis, and excerpts from 225 student responses to a course reflection regarding…

  8. Design considerations to improve cognitive ergonomic issues of unmanned vehicle interfaces utilizing video game controllers.

    Oppold, P; Rupp, M; Mouloua, M; Hancock, P A; Martin, J


    Unmanned (UAVs, UCAVs, and UGVs) systems still have major human factors and ergonomic challenges related to the effective design of their control interface systems, crucial to their efficient operation, maintenance, and safety. Unmanned system interfaces with a human centered approach promote intuitive interfaces that are easier to learn, and reduce human errors and other cognitive ergonomic issues with interface design. Automation has shifted workload from physical to cognitive, thus control interfaces for unmanned systems need to reduce mental workload on the operators and facilitate the interaction between vehicle and operator. Two-handed video game controllers provide wide usability within the overall population, prior exposure for new operators, and a variety of interface complexity levels to match the complexity level of the task and reduce cognitive load. This paper categorizes and provides taxonomy for 121 haptic interfaces from the entertainment industry that can be utilized as control interfaces for unmanned systems. Five categories of controllers were based on the complexity of the buttons, control pads, joysticks, and switches on the controller. This allows the selection of the level of complexity needed for a specific task without creating an entirely new design or utilizing an overly complex design.

  9. Submitted for your consideration: potential advantages of a novel clinical trial design and initial patient reaction

    Matthew Shane Loop


    Full Text Available In many circumstances, individuals do not respond identically to the same treatment. This phenomenon, which is called treatment response heterogeneity (TRH, appears to be present in treatments for many conditions, including obesity. Estimating the total amount of TRH, predicting an individual’s response, and identifying the mediators of TRH are of interest to biomedical researchers. Clinical investigators and physicians commonly postulate that some of these mediators could be genetic. Current designs can estimate TRH as a function of specific, measurable observed factors; however, they cannot estimate the total amount of TRH, nor provide reliable estimates of individual persons’ responses. We propose a new repeated randomizations design (RRD, which can be conceived as a generalization of the Balaam design, that would allow estimates of that variability and facilitate estimation of the total amount of TRH, prediction of an individual’s response, and identification of the mediators of TRH. In a pilot study, we asked 118 subjects entering a weight loss trial for their opinion of the RRD, and they stated a preference for the RRD over the conventional 2-arm parallel groups design. Research is needed as to how the RRD will work in practice and its relative statistical properties, and we invite dialogue about it.

  10. Housing Arrays Following Disasters: Social Vulnerability Considerations in Designing Transitional Communities

    Spokane, Arnold R.; Mori, Yoko; Martinez, Frank


    Displacement and dislocation from homes disrupt fundamental social processes necessary for optimal community functioning. Neighborhood and community social capital, collective efficacy and place attachment are social processes that may be compromised following disaster, conflict, and upheaval. A collaborative approach to the preplanning, design,…

  11. Diversity and constructive conflict in stakeholder dialogue: considerations for design and methods

    Cuppen, E.H.W.J.


    Diversity is generally recognized as a key issue for learning in stakeholder dialogue on wicked sustainability issues. Yet the question on how design of stakeholder dialogue and supporting methods actually enhance learning in stakeholder dialogue deserves more attention. This paper presents construc

  12. Design considerations for arrays of MMCs for X-ray astronomy

    Enss, C. E-mail:; Fleischmann, A.; Bandler, S.R.; Stevenson, T.R.; Seidel, G.M


    There are a number of substantially different ways of fabricating arrays of metallic magnetic calorimeters (MMCs). We discuss different designs and readout schemes and comment on the requirements, advantages and disadvantages of specific MMC arrays. In particular, we address the problems of thermal and inductive cross-talk, thermalization times, heat dissipation, layout and suitable SQUID readout techniques.

  13. Designing Energy Supply Chains with the P-graph Framework under Cost Constraints and Sustainability Considerations

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...

  14. Design considerations for micromechanical sensors using encapsulated built-in resonant strain gauges

    Tilmans, Harrie A.C.; Bouwstra, Siebe; Fluitman, Jan H.J; Spence, Scott L.


    This paper describes the various design aspects for micromechanical sensors consisting of a structure with encapsulated built-in resonant strain gauges. Analytical models are used to investigate the effect of device parameters on the behaviour of a pressure sensor and a force sensor. The analyses in

  15. Designing Energy Supply Chains with the P-graph Framework under Cost Constraints and Sustainability Considerations

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...

  16. Design considerations for examining trends in avian abundance using point counts: examples from oak woodlands

    Kathryn L. Purcell; Sylvia R. Mori; Mary K. Chase


    We used data from two oak-woodland sites in California to develop guidelines for the design of bird monitoring programs using point counts. We used power analysis to determine sample size adequacy when varying the number of visits, count stations, and years for examining trends in abundance. We assumed an overdispersed Poisson distribution for count data, with...

  17. Applying Universal Design for Learning in Online Courses: Pedagogical and Practical Considerations

    Dell, Cindy Ann; Dell, Thomas F.; Blackwell, Terry L.


    Inclusion of the universal design for learning (UDL) model as a guiding set of principles for online curriculum development in higher education is discussed. Fundamentally, UDL provides the student with multiple means of accessing the course based on three overarching principles: presentation; action and expression; and engagement and interaction.…

  18. Sampling design considerations for demographic studies: a case of colonial seabirds

    Kendall, William L.; Converse, Sarah J.; Doherty, Paul F.; Naughton, Maura B.; Anders, Angela; Hines, James E.; Flint, Elizabeth


    For the purposes of making many informed conservation decisions, the main goal for data collection is to assess population status and allow prediction of the consequences of candidate management actions. Reducing the bias and variance of estimates of population parameters reduces uncertainty in population status and projections, thereby reducing the overall uncertainty under which a population manager must make a decision. In capture-recapture studies, imperfect detection of individuals, unobservable life-history states, local movement outside study areas, and tag loss can cause bias or precision problems with estimates of population parameters. Furthermore, excessive disturbance to individuals during capture?recapture sampling may be of concern because disturbance may have demographic consequences. We address these problems using as an example a monitoring program for Black-footed Albatross (Phoebastria nigripes) and Laysan Albatross (Phoebastria immutabilis) nesting populations in the northwestern Hawaiian Islands. To mitigate these estimation problems, we describe a synergistic combination of sampling design and modeling approaches. Solutions include multiple capture periods per season and multistate, robust design statistical models, dead recoveries and incidental observations, telemetry and data loggers, buffer areas around study plots to neutralize the effect of local movements outside study plots, and double banding and statistical models that account for band loss. We also present a variation on the robust capture?recapture design and a corresponding statistical model that minimizes disturbance to individuals. For the albatross case study, this less invasive robust design was more time efficient and, when used in combination with a traditional robust design, reduced the standard error of detection probability by 14% with only two hours of additional effort in the field. These field techniques and associated modeling approaches are applicable to studies of

  19. Design Considerations and Economics of Water Harvesting System for Crop Production

    Pali, A. K.


    By and large, the design of water harvesting pond is generally based on thumb rules and needs to be upgraded on scientific and engineering principles. In this study, the design procedure of on-farm water harvesting pond has been discussed and two farm ponds of circular, rectangular and square shapes were designed for 50, 60, 75 and 80 % probability of occurrence of rainfall and runoff. Though, the circular shape resulted in the least mean water surface area, but due to not being practicable for agricultural operations, it was discarded. The square shaped ponds resulted in giving least water surface areas as 0.761 ha for the micro watershed of 8.19 ha and as 0.246 ha for the micro watershed of 1.7 ha at 80 % probability level of rainfall and runoff at 80 % level of probability. The storage capacity of the first pond was found as 32,314 m3 and it was 12,962 m3 for the second farm pond. The area to be occupied by the two ponds was worked out as about 11 % of the total land area (8.19 ha) of the first micro watershed and about 18-22 % of the area (1.7 ha) of second micro watershed. Results indicated that the designed size of the first farm pond can be acceptable for construction. The economics of farm pond based agricultural production showed that the highest B/C ratio of 2 and 1.9 were possible for the farm pond designed at 80 and 75 % probability of occurrence of rainfall and runoff respectively.

  20. Invited review: study design considerations for clinical research in veterinary radiology and radiation oncology.

    Scrivani, Peter V; Erb, Hollis N


    High quality clinical research is essential for advancing knowledge in the areas of veterinary radiology and radiation oncology. Types of clinical research studies may include experimental studies, method-comparison studies, and patient-based studies. Experimental studies explore issues relative to pathophysiology, patient safety, and treatment efficacy. Method-comparison studies evaluate agreement between techniques or between observers. Patient-based studies investigate naturally acquired disease and focus on questions asked in clinical practice that relate to individuals or populations (e.g., risk, accuracy, or prognosis). Careful preplanning and study design are essential in order to achieve valid results. A key point to planning studies is ensuring that the design is tailored to the study objectives. Good design includes a comprehensive literature review, asking suitable questions, selecting the proper sample population, collecting the appropriate data, performing the correct statistical analyses, and drawing conclusions supported by the available evidence. Most study designs are classified by whether they are experimental or observational, longitudinal or cross-sectional, and prospective or retrospective. Additional features (e.g., controlled, randomized, or blinded) may be described that address bias. Two related challenging aspects of study design are defining an important research question and selecting an appropriate sample population. The sample population should represent the target population as much as possible. Furthermore, when comparing groups, it is important that the groups are as alike to each other as possible except for the variables of interest. Medical images are well suited for clinical research because imaging signs are categorical or numerical variables that might be predictors or outcomes of diseases or treatments. © 2013 Veterinary Radiology & Ultrasound.

  1. Inductorless bi-directional piezoelectric transformerbased converters: Design and control considerations

    Ekhtiari, Marzieh

    , this brings an open area for conducting further research which has been subject of this project. The research on this type of power converters are progressive but still very new in the technology to become a successful commercial product. The unique characteristics of piezoelectric transformers i.e. low...... electromagnetic interference, compact, light, high power density and low cost allows for promising market in the near future. The piezoelectric transformer technology has the potential to be used in various applications e.g. motor driver for magnetic resonance imaging scans, the electronic ballast for fluorescent...... lamps, backlight for LCD displays in notebook computers. Piezoelectric ceramic devices vibrate at their mechanical resonance. The operating principle of the piezoelectric transformers is based on electromechanical energy conversion. There is electromechanical coupling between the primary...

  2. Considerations In The Design And Specifications Of An Automatic Inspection System

    Lee, David T.


    Considerable activities have been centered around the automation of manufacturing quality control and inspection functions. Several reasons can be cited for this development. The continuous pressure of direct and indirect labor cost increase is only one of the obvious motivations. With the drive for electronics miniaturization come more and more complex processes where control parameters are critical and the yield is highly susceptible to inadequate process monitor and inspection. With multi-step, multi-layer process for substrate fabrication, process defects that are not detected and corrected at certain critical points may render the entire subassembly useless. As a process becomes more complex, the time required to test the product increases significantly in the total build cycle. The urgency to reduce test time brings more pressure to improve in-process control and inspection. The advances and improvements of components, assemblies and systems such as micro-processors, micro-computers, programmable controllers, and other intelligent devices, have made the automation of quality control much more cost effective and justifiable.

  3. Fire Safety Consideration in the Pre-conceptual Design State of Pyro-Facillity

    Jeon, Hong Rae; Seo, Seok Jun; Lee, Hyo Jik [KAERI, Daejeon (Korea, Republic of)


    The government, in order to solve this problem, has organized a public engagement committee and is searching for a solution. To use sustainable nuclear energy, our country is also pursuing research and development of fast breeder reactor and pyroprocessing technology in accordance with the international movement of spent fuel recycling and efforts towards nuclear non-proliferation which is centered on the development and demonstration of recycling spent fuel and fast breeder reactors. Pyro-facility has different features with nuclear power plant. In the pyroprocess, chemical and electrochemical separation were took place in the hot cells and material at risk (MAR) is distributed in many working areas. In this paper, we conducted the fire modeling of hot cells to see the stability of pyrophoric materials which is considered as one of the potential hazardous materials in the main process cell. Based on modeling results, consideration of fire safety pyrofacility will be discussed. We performed preliminary hazard analysis for pyrofacility and summarized potential fire hazard. Pyrophoric material fire is the dominant hazard in the main process hot cell and fire modeling of cable tray in the cell was analyzed to see the stability of pyrophoric materials. Analysis results clearly shows that pyrophoric materials are prone to be affected.

  4. Mechanism of operation and design considerations for surface acoustic wave device vapor sensors

    Wohltjen, H.


    Surface acoustic wave (SAW) devices offer many attractive features for application as vapor phase chemical microsensors. This paper describes the characteristics of SAW devices and techniques by which they can be employed as vapor sensors. The perturbation of SAW amplitude and velocity by polymeric coating films was investigated both theoretically and experimentally. High sensitivity can be achieved when the device is used as the resonating element in a delay line oscillator circuit. A simple equation has been developed from theoretical considerations which offers reasonably accurate quantitative predictions of SAW Device frequency shifts when subjected to a given mass loading. In this mode the SAW device behaves in a fashion very similar to conventional bulk wave quartz crystal microbalance except that the sensitivity can be several orders of magnitude higher and the device size can be several orders of magnitude smaller. Detection of mass changes of less than 1 femtogram by a SAW device having a surface area of 0.0001 square cm. is theoretically possible.

  5. The capacity of duckweed to treat wastewater: ecological considerations for a sound design.

    Körner, Sabine; Vermaat, Jan E; Veenstra, Siemen


    Duckweed species are promising macrophytes for use in sustainable wastewater treatment due to their rapid growth, ease of harvest, and feed potential as a protein source. This paper reviews growth rates of different duckweed species on wastewater and ammonia toxicity to duckweed and summarizes insights into the mechanism of organic matter and nutrient removal. Results were gained from laboratory experiments in small, shallow, duckweed-covered semicontinuous batch systems. Growth rates on different types of wastewater vary considerably among different species. Ammonia is toxic for duckweed in both the ionized and un-ionized forms. Duckweed, however, can be used to treat wastewater containing very high total ammonia concentrations as long as certain pH levels are not exceeded. The degradation of organic material is enhanced by duckweed through both additional oxygen supply and additional surface for bacterial growth. The duckweed mat with attached bacteria and algae is, independent of the loading rates, responsible for three-quarters of the total nitrogen (N) and phosphorus (P) loss in very shallow systems. Based on our results we suggest that full-scale pilot plants with duckweed should be shallower than the range encountered in the literature. A harvesting schedule that allows doubling times of 2 to 3.5 d, maintenance of a full coverage, and plug flow conditions are recommended.

  6. Design considerations for a steam-injection pilot with in-situ foaming

    Siddiqui, M.H.; Sanyal, S.K.; Horn, A.J.


    This report reviews the necessary aspects of the planning, operation, evaluation, environmental impact and cost to implement a field pilot of steam injection with in-situ foaming. The Stanford University Petroleum Research Institute (SUPRI) is planning to implement such a pilot in Kern County, California. The cost of the pilot will be shared by the US Department of Energy and an oil company. Some important aspects of drilling and completion programs and their specifications, permits from regulatory bodies, and downhole tools to improve steam stimulation are discussed. The essential surface facilities which include water treatment plant, steam generator, demulsifier and dehydrator are considered. The necessary laboratory research in support of the pilot has been recommended. The formation evaluation and reservoir engineering effort for the pilot has been divided into three phases: reservoir definition, reservoir monitoring and post-pilot study. Appropriate techniques applicable to each phase of the test have been discussed. The environmental impact regulations as related to the steam injection process have been considered. In particular, the environmental problems associated with the burning of crude oil and desulfurization of flue gas have been discussed. Other environmental considerations such as solid and liquid waste disposal, health and safety are also discussed. An estimate of the cost of this field test is presented. Three scenarii (for pilots with high, medium, and low investment potentials, respectively) are presented. Since this report was prepared, a specific site for the supri pilot has been chosen. Appendices G and H present the details on this site.

  7. Considerations for the Design of a central counterparty for the Mexican Money Market

    Miguel de Lascurain M.


    Full Text Available The financial crisis has brought the problems of regulatory failure and unbridled counterparty risk to the forefront in financial discussions. In the last decade, central counterparties have been created in order to face those insidious problems. In Mexico, both the stock and the derivatives markets have central counterparties, but the money market has not. This paper addresses the issue of creating a central counterparty for the Mexican money market. Recommendations that must be followed in the design and the management of risk of a central counterparty, given by international regulatory institutions, are presented in this study. Also, two different conceptual designs for a central counterparty, appropriate for the Mexican market, are proposed. Final conclusions support the creation of a new central counterparty for the Mexican money market.

  8. Design Considerations for Miniaturized Control Moment Gyroscopes for Rapid Retargeting and Precision Pointing of Small Satellites

    Patankar, Kunal; Fitz-Coy, Norman; Roithmayr, Carlos M.


    This paper presents the design as well as characterization of a practical control moment gyroscope (CMG) based attitude control system (ACS) for small satellites in the 15-20 kilogram mass range performing rapid retargeting and precision pointing maneuvers. The paper focuses on the approach taken in the design of miniaturized CMGs while considering the constraints imposed by the use of commercial off-the-shelf (COTS) components as well as the size of the satellite. It is shown that a hybrid mode is more suitable for COTS based moment exchange actuators; a mode that uses the torque amplification of CMGs for rapid retargeting and direct torque capabilities of the flywheel motors for precision pointing. A simulation is provided to demonstrate on-orbit slew and pointing performance.

  9. Design considerations for a digital audio Class D output stage with emphasis on hearing aid application

    Pracný, Peter

    that the switching frequency of the Class D power amplifier – the main power consumer in the back end - is minimized. • In the multistage interpolation filter the first stage is implemented as a half-band IIR filter consisting of two parallel all-pass cells. A novel approach that does not require any rigorous...... numerical techniques is proposed to quantize the filter coefficients. Together with the simple all-pass cells the resulting filter has very low hardware / power demands compared to the state-of-the-art. • The switching frequency of the Class D power amplifier is reduced at the cost of the increase...... of the maximum clock frequency in the digital part of the back end. This approach moves the burden from the Class D power amplifier to the digital part, which easily scales with the IC technologies of today - optimized for digital design. • Judging by the figure-of-merit five design iterations are performed...

  10. Design considerations for concentrating solar power tower systems employing molten salt.

    Moore, Robert Charles; Siegel, Nathan Phillip; Kolb, Gregory J.; Vernon, Milton E.; Ho, Clifford Kuofei


    The Solar Two Project was a United States Department of Energy sponsored project operated from 1996 to 1999 to demonstrate the coupling of a solar power tower with a molten nitrate salt as a heat transfer media and for thermal storage. Over all, the Solar Two Project was very successful; however many operational challenges were encountered. In this work, the major problems encountered in operation of the Solar Two facility were evaluated and alternative technologies identified for use in a future solar power tower operating with a steam Rankine power cycle. Many of the major problems encountered can be addressed with new technologies that were not available a decade ago. These new technologies include better thermal insulation, analytical equipment, pumps and values specifically designed for molten nitrate salts, and gaskets resistant to thermal cycling and advanced equipment designs.

  11. Design Considerations for CMOS-Integrated Hall-Effect Magnetic Bead Detectors for Biosensor Applications.

    Skucha, K; Gambini, S; Liu, P; Megens, M; Kim, J; Boser, Be


    We describe a design methodology for on-chip magnetic bead label detectors based on Hall-effect sensors. Signal errors caused by the label-binding process and other factors that limit the minimum detection area are quantified and adjusted to meet typical assay accuracy standards. The methodology is demonstrated by designing an 8192 element Hall sensor array, implemented in a commercial 0.18 μm CMOS process with single-mask postprocessing. The array can quantify a 1% surface coverage of 2.8 μm beads in 30 seconds with a coefficient of variation of 7.4%. This combination of accuracy and speed makes this technology a suitable detection platform for biological assays based on magnetic bead labels.

  12. Frequency response and design consideration of GaN SAM avalanche photodiodes

    Xie, Feng; Yang, Guofeng; Zhou, Dong; Lu, Hai; Wang, Guosheng


    In this work, a method is developed for estimating the frequency response characteristics of GaN avalanche photodiodes (APDs) with separated absorption and multiplication regions (SAM). The method calculates the total diode current with varying frequency by solving transport equations analytically and uses a commercial device simulator as a supplement for determining the exact electrical field profile within the device. Due to the high carrier saturation velocity of GaN, a high-gain-bandwidth product over THz is found achievable for GaN SAM-APDs. The potential performances of GaN SAM-APDs with different structural designs are further compared through numerical studies. It is found that a close-to-reach-through design is attractive for simultaneously achieving both relatively low operation voltage and high working frequency. In addition, transit-time limit and RC-delay limit for the frequency response of GaN SAM-APDs are also discussed.

  13. Design considerations of a linear generator for a range extender application

    Seo Un-Jae


    Full Text Available The free piston linear generator is a new range extender concept for the application in a full electric vehicle. The free piston engine driven linear generators can achieve high efficiency at part and full load which is suitable for the range extender application. This paper presents requirements for designing a linear generator deduced from a basic analysis of a free piston linear generator.

  14. Design Considerations for a Water Treatment System Utilizing Ultra-Violet Light Emitting Diodes


    industry use for UV fluorescent bulb type water disinfection systems (Aquionics, 2013). Shorter wavelength LEDs (240 nm) were shown to be in its infancy and research as it applies to UV water treatment is required to advance knowledge for practical application. This thesis focused...on two subjects. First, the design, fabrication, and operation of a water treatment reaction system utilizing Ultra-Violet ( UV ) Light Emitting

  15. Mix design considerations and performance characteristics of foamed bitumen mixtures (FBMs)

    Kuna, Kranthi


    The sustainability issues in pavement materials and design form a strong incentive for the present work. Using recycled materials in pavements is a sustainable practice that is gaining adoption, particularly for flexible (bituminous) pavements. One approach is to incorporate large quantities of Reclaimed Asphalt Pavement (RAP) into base and sub-base applications for pavement construction. Numerous studies have reported that RAP can be reused as an aggregate in Hot Mix Asphalt (HMA) as well as...

  16. Methodological Considerations in the Design of Large Scale Systems Engineering Processes.


    Tversky, A., "Prospect Theory : An Analysis of Decision Under Risk", Econometrica, vol. 47, March 1979, pp. 263-291. Inhelder, B. and Piaget , J., The...concerned with the mathematical and behavioral theory of systems. This we will call systems science and operations research. Also, it says that we...will be con- cerned with a combination of these theories . We will denote the effort to obtain this combination systems methodology and design. Finally

  17. Optimal design variable considerations in the use of phase change materials in indirect evaporative cooling

    Chilakapaty, Ankit Paul

    The demand for sustainable, energy efficient and cost effective heating and cooling solutions is exponentially increasing with the rapid advancement of computation and information technology. Use of latent heat storage materials also known as phase change materials (PCMs) for load leveling is an innovative solution to the data center cooling demands. These materials are commercially available in the form of microcapsules dispersed in water, referred to as the microencapsulated phase change slurries and have higher heat capacity than water. The composition and physical properties of phase change slurries play significant role in energy efficiency of the cooling systems designed implementing these PCM slurries. Objective of this project is to study the effect of PCM particle size, shape and volumetric concentration on overall heat transfer potential of the cooling systems designed with PCM slurries as the heat transfer fluid (HTF). In this study uniform volume heat source model is developed for the simulation of heat transfer potential using phase change materials in the form of bulk temperature difference in a fully developed flow through a circular duct. Results indicate the heat transfer potential increases with PCM volumetric concentration with gradually diminishing returns. Also, spherical PCM particles offer greater heat transfer potential when compared to cylindrical particles. Results of this project will aid in efficient design of cooling systems based on PCM slurries.

  18. A broader consideration of human factor to enhance sustainable building design.

    Attaianese, Erminia


    The link between ergonomic/human factor and sustainability seems to be clearly evidenced mainly in relation to social dimension of sustainability, in order to contribute to assure corporate social responsibility and global value creation. But the will to establish an equilibrated connection among used resources in human activities, supported by the sustainability perspective, evidences that the contribution of ergonomics/human factors can be effectively enlarged to other aspects, especially in relation to building design. In fact a sustainable building is meant to be a building that contributes, through its characteristics and attribute, to a sustainable development by assuring, in the same time, a decrease of resources use and environmental impact and an increase of health, safety and comfort of the occupants. The purpose of this paper is to analyze in a broader sense the contribution of ergonomic/human factor to design of sustainable building, focusing how ergonomics principles, methodology and techniques can improve building design, enhancing its sustainability performance during all phases of building lifecycle.

  19. Considerations on the design and financial feasibility of full-scale membrane bioreactors for municipal applications.

    Brepols, Ch; Schäfer, H; Engelhardt, N


    Based on the practical experience in design and operation of three full-scale membrane bioreactors (MBR) for municipal wastewater treatment that were commissioned since 1999, an overview on the different design concepts that were applied to the three MBR plants is given. The investment costs and the energy consumption of the MBRs and conventional activated sludge (CAS) plants (with and without tertiary treatment) in the Erft river region are compared. It is found that the specific investment costs of the MBR plants are lower than those of comparable CAS with tertiary treatment. A comparison of the specific energy demand of MBRs and conventional WWTPs is given. The structure of the MBRs actual operational costs is analysed. It can be seen that energy consumption is only responsible for one quarter to one third of all operational expenses. Based on a rough design and empirical cost data, a cost comparison of a full-scale MBR and a CAS is carried out. In this example the CAS employs a sand filtration and a disinfection in order to achieve comparable effluent quality. The influence of membrane lifetime on life cycle cost is assessed.

  20. Information architecture considerations in designing a comprehensive tuberculosis enterprise system in Western Kenya.

    Gichoya, Judy; Pearce, Chris; Wickramasinghe, Nilmini


    Kenya ranks among the twenty-two countries that collectively contribute about 80% of the world's Tuberculosis cases; with a 50-200 fold increased risk of tuberculosis in HIV infected persons versus non-HIV hosts. Contemporaneously, there is an increase in mobile penetration and its use to support healthcare throughout Africa. Many are skeptical that such m-health solutions are unsustainable and not scalable. We seek to design a scalable, pervasive m-health solution for Tuberculosis care to become a use case for sustainable and scalable health IT in limited resource settings. We combine agile design principles and user-centered design to develop the architecture needed for this initiative. Furthermore, the architecture runs on multiple devices integrated to deliver functionality critical for successful Health IT implementation in limited resource settings. It is anticipated that once fully implemented, the proposed m-health solution will facilitate superior monitoring and management of Tuberculosis and thereby reduce the alarming statistic regarding this disease in this region.

  1. Anthropological perspectives on money management: considerations for the design and implementation of interventions for substance abuse.

    Carpenter-Song, Elizabeth


    There remains a long-standing argument regarding the need for money management strategies to control poor spending habits among people with substance use disorders. The objective was to review issues relevant to the design and implementation of money-management-based interventions for substance abuse. Using a comparative, cross-cultural framework of anthropology, this manuscript examines three challenges for the design and implementation of money management interventions for substance abuse: (i) clients may not trust mental health centers to manage their money, (ii) clients may have different economic perspectives from clinicians and researchers, and (iii) clients may obtain substances through informal networks of exchange. This article clarifies the inherently complex symbolic and social dimensions of money and addiction and illustrates the need for researchers and clinicians to be mindful of the cultural assumptions that underlie money management interventions for substance abuse. Using an anthropological approach toward understanding the issues surrounding money management for individuals struggling with addiction and mental illness has the potential to strengthen the design and implementation of money-management-based interventions in a manner that is acceptable and meaningful for this target population.

  2. Design considerations and challenges for mechanical stretch bioreactors in tissue engineering.

    Lei, Ying; Ferdous, Zannatul


    With the increase in average life expectancy and growing aging population, lack of functional grafts for replacement surgeries has become a severe problem. Engineered tissues are a promising alternative to this problem because they can mimic the physiological function of the native tissues and be cultured on demand. Cyclic stretch is important for developing many engineered tissues such as hearts, heart valves, muscles, and bones. Thus a variety of stretch bioreactors and corresponding scaffolds have been designed and tested to study the underlying mechanism of tissue formation and to optimize the mechanical conditions applied to the engineered tissues. In this review, we look at various designs of stretch bioreactors and common scaffolds and offer insights for future improvements in tissue engineering applications. First, we summarize the requirements and common configuration of stretch bioreactors. Next, we present the features of different actuating and motion transforming systems and their applications. Since most bioreactors must measure detailed distributions of loads and deformations on engineered tissues, techniques with high accuracy, precision, and frequency have been developed. We also cover the key points in designing culture chambers, nutrition exchanging systems, and regimens used for specific tissues. Since scaffolds are essential for providing biophysical microenvironments for residing cells, we discuss materials and technologies used in fabricating scaffolds to mimic anisotropic native tissues, including decellularized tissues, hydrogels, biocompatible polymers, electrospinning, and 3D bioprinting techniques. Finally, we present the potential future directions for improving stretch bioreactors and scaffolds. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:543-553, 2016.

  3. Curriculum design in transformation: consideration about educational institutions and beyond them

    FELDMANN, Marina Graziela; MASETTO, Marcos Tarciso

    Full Text Available This article looks for calling to the attention of our readers some thoughts about the need to rethink the curriculum designs in our educational institutions, most of which still remain with a curriculum of traditional organization called features. Currently, both the authors who write about the significance of education in our society, such as curriculum experts warn of the need to review our curricula. It’s a compulsory agenda in many conferences and educational events. In the course of these concerns, we bring our collaboration nowadays. For the case of transformation of a curriculum design it´s is necessary to agree on a conception of curriculum, its historical contextualization, the redefinition and reorganization of the elements that compose it and the current demands that a curriculum should respond. In this article, we will discuss two aspects that appear to contain special relevance to our theme: the first concerns the design of curriculum and its developments; and the second, the teaching staff and their training in curriculum redesign.

  4. Creating healing intensive care unit environments: physical and psychological considerations in designing critical care areas.

    Bazuin, Doug; Cardon, Kerrie


    A number of elements contribute to a healing ICU environment. The layout of a critical care unit helps create an environment that supports caregiving, which helps alleviate a host of work-related stresses. A quieter environment, one that includes family and friends, dotted with windows and natural light, creates a space that makes people feel balanced and reassured. A healing environment responds to the needs of all the people within a critical care unit-those who receive or give care and those who support patients and staff. Critical care units should be designed to focus on healing the body, the mind, and the senses. The design and policies of that department can be created in such a way to provide a sense of calm and balance. The physical environment has an impact on patient outcomes; the psychological environment can, too. A healing ICU environment will balance both. The authors discuss the ways in which architecture, interior design, and behavior contribute to a healing ICU environment.

  5. Design of horizontal test cryostat for testing two 650 MHz cavities: cryogenic considerations

    Khare, P.; Gilankar, S.; Kush, P. K.; Lakshminarayanan, A.; Choubey, R.; Ghosh, R.; Jain, A.; Patel, H.; Gupta, P. D.; Hocker, A.; Ozelis, J. P.; Geynisman, M.; Reid, C.; Poloubotko, V.; Mitchell, D.; Peterson, T. J.; Nicol, T. H.


    Horizontal Test Cryostat has been designed for testing two 650 MHz "dressed" Superconducting Radio Frequency (SCRF) cavities in a single testing cycle at Raja Ramanna Centre for Advanced Technology, India (RRCAT) in collaboration with Fermi National Accelerator Laboratory, USA (FNAL). This cryostat will facilitate testing of two 5-cell 650 MHz SCRF cavities, in CW or pulsed regime, for upcoming High Intensity Superconducting Proton Accelerator projects at both countries. Two such HTS facilities are planned, one at RRCAT for Indian Spallation Neutron Source project (ISNS), which is on the horizon, and the other at FNAL, USA. A test cryostat, a part of horizontal test stand-2 (HTS-2) will be set up at RRCAT for Indian project. In order to maximize the utility of this facility, it can also be used to test two dressed 9-cell 1.3 GHz cavities and other similarly-sized devices. The facility assumes, as an input, the availability of liquid nitrogen at 80 K and liquid helium at 4.5 K and 2 K, with a refrigeration capacity of approximately 50 W at 2 K. Design work of cryostat has been completed and now procurement process is in progress. This paper discusses salient features of the cryostat. It also describes different design calculations and ANSYS analysis for cool down of few subsystems like cavity support system and liquid nitrogen cooled thermal radiation shield of horizontal test cryostat..

  6. 30 CFR 250.916 - What are the CVA's primary duties during the design phase?


    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the CVA's primary duties during the... Structures Platform Verification Program § 250.916 What are the CVA's primary duties during the design phase? (a) The CVA must use good engineering judgement and practices in conducting an independent assessment...

  7. How to stay heart healthy in 2011: considerations for the primary prevention of cardiovascular disease in women.

    Davis, Melinda B; Duvernoy, Claire S


    More women die of cardiovascular disease than any other cause. Effective primary prevention depends on accurate assessment of risk status. While most risk factors are similar for men and women, risk factors may differ in magnitude between the sexes, and recognition of gender-specific risk factors such as gestational diabetes, hypertensive syndromes of pregnancy and polycystic ovarian syndrome provides opportunities for early intervention and prevention. Obesity, hypertension and hyperlipidemia affect both genders; however, women often postpone addressing these risk factors until later in life. The American Heart Association emphasizes that all women are at cardiovascular risk and should maintain a healthy lifestyle and avoid smoking. Blood pressure, hyperlipidemia and diabetes should be aggressively treated. Current available data regarding proposed preventive drug therapies including daily aspirin, HRT, vitamin D and omega-3 fatty acid supplements will be reviewed.

  8. Primary retroperitoneal mucinous cystadenoma with a sarcoma-like mural nodule: an immunohistochemical study with histogenetic considerations and literature review.

    Demirel, Dilaver; Gun, Ismet; Kucukodaci, Zafer; Balta, Ahmet Ziya; Ramzy, Ibrahim


    Primary retroperitoneal mucinous cystadenomas (PRMCs) are extremely rare tumors and their association with sarcoma-like mural nodules (SLMNs) has not been described thoroughly. The aim of this study is to characterize the gross and microscopic features and the immunohistochemical profile of the first case of PRMC with SLMN and to discuss the differential diagnosis of SLMNs. The literature related to primary retroperitoneal mucinous tumors is reviewed in an attempt to clarify the histogenesis of the epithelial and sarcomatoid components of the associated mural nodules. A 34-yr-old woman presented with a 14-cm retroperitoneal cystic lesion with a 6-cm mural nodule. An immunohistochemical study with a panel of 19 antibodies and a histochemical study for mucin stains were performed. The epithelial component of the PRMC showed positive staining for cytokeratin (CK) 7, CK AE1/3, epithelial membrane antigen, carcinoembryonic antigen, and calretinin. The neoplasm was not immunoreactive for CK 20, CK 5/6, and the other antibodies used in this study. In addition, it stained positively for mucin by mucicarmine, periodic acid-Schiff, and Alcian blue. The stromal cells of the cyst showed estrogen receptor positivity. SLMN cells were negative for all CKs and other epithelial markers used in the study, but they showed diffuse positive staining for vimentin and CD68, and positive staining for Ki-67 was demonstrated in 25% of these cells. The immunohistochemical and histochemical profiles of PRMC were similar to those of ovarian mucinous neoplasms and the mesothelium. The formation of SLMNs seems to be related to subepithelial hemorrhage and some reactive epithelial changes near the mural nodules. The specific immunohistochemical and morphologic features of SLMNs are helpful in differentiating them from malignant mural nodules, including true sarcomas, osteoclast-rich undifferentiated carcinomas, and carcinosarcomas. Such a differentiation is critical in view of its significant

  9. Electrolyte management considerations in modern nickel hydrogen and nickel cadmium cell and battery designs

    Thaller, L. H.; Zimmerman, A. H.


    In the early 1980's the NASA Lewis group addressed the topic of designing nickel hydrogen cells for LEO applications. As published in 1984, the design addressed the topics of gas management, liquid management, plate expansion, and the recombination of oxygen during overcharge. This design effort followed principles set forth in an earlier Lewis paper that addressed the topic of pore size engineering. At about that same time, the beneficial effect on cycle life of lower electrolyte concentrations was verified by Hughes Aircraft as part of a Lewis funded study. A succession of life cycle tests of these concepts have been carried out that essentially verified all of this earlier work. During these past two decades, some of the mysteries involved in the active material of the nickel electrode have been resolved by careful research efforts carried out at several laboratories. At The Aerospace Corporation, Dr. Zimmerman has been developing a sophisticated model of an operating nickel hydrogen cell which will be used to model certain mechanisms that have contributed to premature failures in nickel hydrogen and nickel cadmium cells. During the course of trying to understand and model abnormal nickel hydrogen cell behaviors, we have noted that not enough attention has been paid to the potassium ion content in these cells, and more recently batteries. Several of these phenomenon have been well known in the area of alkaline fuel cells, but only recently have they been examined as they might impact alkaline cell designs. This paper will review three general areas where the potassium ion content can impact the performance and life of nickel hydrogen and nickel cadmium devices, Once these phenomenon are understood conceptually, the impact of potassium content on a potential cell design can be evaluated with the aid of an accurate model of an operating cell or battery. All three of these areas are directly related to the volume tolerance and pore size engineering aspects of the

  10. Syngas fermentation in a 100-L pilot scale fermentor: design and process considerations.

    Kundiyana, Dimple K; Huhnke, Raymond L; Wilkins, Mark R


    Fermentation of syngas offers several advantages compared to chemical catalysts such as higher specificity of biocatalysts, lower energy costs, and higher carbon efficiency. Scale-up of syngas fermentation from a bench scale to a pilot scale fermentor is a critical step leading to commercialization. The primary objective of this research was to install and commission a pilot scale fermentor, and subsequently scale-up the Clostridium strain P11 fermentation from a 7.5-L fermentor to a pilot scale 100-L fermentor. Initial preparation and fermentations were conducted in strictly anaerobic conditions. The fermentation system was maintained in a batch mode with continuous syngas supply. The effect of anaerobic fermentation in a pilot scale fermentor was evaluated. In addition, the impact of improving the syngas mass transfer coefficient on the utilization and product formation was studied. Results indicate a six fold improvement in ethanol concentration compared to serum bottle fermentation, and formation of other compounds such as isopropyl alcohol, acetic acid and butanol, which are of commercial importance.

  11. Coil design considerations for a high-frequency electromagnetic induction sensing instrument

    Sigman, John B.; Barrowes, Benjamin E.; Wang, Yinlin; Bennett, Hollis J.; Simms, Janet E.; Yule, Donald E.; O'Neill, Kevin; Shubitidze, Fridon


    Intermediate electrical conductivity (IEC) materials (101S/m IEC objects. Recent analytical and numerical studies have showed that these targets exhibit characteristic quadrature response peaks at high induction frequencies (100kHz - 15MHz, the High Frequency Electromagnetic Induction (HFEMI) band), and they are not detectable with traditional ultra wideband (UWB) electromagnetic induction (EMI) metal detectors operating between 100Hz - 100kHz. Using the HFEMI band for induction sensing is not so simple as driving existing instruments at higher frequencies, though. At low frequency, EMI systems use more wire turns in transmit and receive coils to boost signal-to-noise ratios (SNR), but at higher frequencies, the transmitter current has non-uniform distribution along the coil length. These non-uniform currents change the spatial distribution of the primary magnetic field and disturb axial symmetry and thwart established approaches for inferring subsurface metallic object properties. This paper discusses engineering tradeoffs for sensing with a broader band of frequencies ever used for EMI sensing, with particular focus on coil geometries.

  12. Design considerations for micro- and nanopositioning: leveraging the latest for biophysical applications.

    Jordan, S C; Anthony, P C


    Biophysical applications ranging from fluorescence microassays to single-molecule microscopy are increasingly dependent on automated nanoscale positional control and stability. A whirlwind of motion-industry innovation has resulted in an array of new motion options offering significant improvements in application performance, reproducibility and throughput. The challenge to leverage these developments depends on researchers, engineers and motion vendors acquiring a common language of specifications and a shared understanding of the challenges posed by application needs. To assist in building this shared understanding, this article reviews today's motion technologies, beginning with a concise review of key principles of motion control focusing on applications. It progresses through illustrations of sensor/encoder technologies and servo techniques. A spectrum of classical and recent motion technologies is explored, from stepper and servo actuation of conventional microscopy stages, to advanced piezo stack nanopositioners capable of picometer precision, to novel ultrasonic resonant piezomotors and piezo-ceramic-based mechanisms capable of high-force positioning over many millimeters while providing resolutions down into the sub-nanometer range. A special emphasis is placed on the effects of integrating multiple motion technologies into an application, such as stacking a fine nanopositioner atop a long-travel stage. Examples and data are presented to clarify these issues, including important and insightful new stability measurements taken directly from an advanced optical trapping application. The important topics of software and interfacing are also explored from an applications perspective, since design-and-debugging time, synchronization capabilities and overall throughput are heavily dependent on these often-overlooked aspects of motion system design. The discussion is designed to illuminate specifications-related topics that become increasingly important as

  13. Considerations for Altering Preparation Designs of Porcelain Inlay/Onlay Restorations for Nonvital Teeth.

    Homsy, Foudda; Eid, Rita; El Ghoul, Wiam; Chidiac, Jose Johann


    The aim of this study was to compare all ceramic inlay/onlay survival rates in vital and nonvital teeth having the same cavity design. Filling the pulp chamber with ceramic materials or not was also discussed. Ceramic class II inlays/onlays were made on 11 premolars and 30 molars: 14 vital, 27 endodontically treated. The same tooth preparation design was performed on vital and nonvital teeth: In nonvital teeth the pulp chambers were covered by a glass ionomer cement until the pulpal floor depths were between 2 and 2.5 mm, more likely similar to the vital teeth preparations. In vital teeth, glass ionomer was used as a liner to achieve pulpal floor depths between 2 and 2.5 mm when needed. The restorations were assessed (at baseline, 6 months, 1 and 2 years) according to three criteria: marginal discoloration, marginal integrity, and fracture of teeth/restorations, consistent with United States Public Health Service (USPHS) criteria. Eight teeth (19%) showed minor marginal discolorations, while three molars (7%) had loss of marginal integrity. These margins were adjusted using rubber polishing cups and were then judged clinically acceptable. From these three molars, one was vital and two were endodontically treated. No fracture of teeth or restorations was observed. Chi square and exact probability tests were used. There was no statistical difference between vital and nonvital teeth (p = 0.719 chi-squared and Fisher) or between premolars and molars (p = 0.564 chi-squared; 1.000, Fisher). Within the limitations of this study there was no difference for the same inlay/onlay cavity design between vital and nonvital teeth. In nonvital teeth, it seems that filling the pulp chamber with a ceramic core material is not important. Long-term observation periods are needed to reinforce the clinical behavior outcome. © 2015 by the American College of Prosthodontists.

  14. Bioreactor design considerations in the production of high-quality microbial exopolysaccaride

    Lawford, H.G.; Rousseau, J.D. [Univ. of Toronto, Ontario (Canada)


    An examination into the effect of bioreactor design on the production of {beta},1,3-glucan exopolysaccharide ({open_quotes}curdlan{close_quotes}) by selected patent cultures of Alcaligenes faecalis and Agrobacterium radiobacter revealed that low shear mixing achieved through the replacement of the radial-flow flat-blade impellers that are commonly supplied in {open_quotes}standard{close_quotes} commercial bioreactors, by low shear (high-pumping) axial-flow impellers, leads to an increase in the quality of the exopolymer recovered during the stationary-phase of batch fermentations. Whereas {open_quotes}Rushton turbine{close_quotes} impellers were effective in providing high rates of oxygen transfer necessary for high cell density fermentations, the high shear-to-flow ratio characteristic of this design produced a product of inferior quality, but with characteristics very similar to that of the commercially available {open_quotes}curdlan standard.{close_quotes} Curdlan is water insoluble, and consequently, the fermentation broth is of a relative low viscosity compared to other soluble microbial polysaccharides. Whereas curdlan does not constrain mass transfer from gas to liquid, it nevertheless offers a resistance to oxygen transfer from the liquid to the cell by virtue of the layer of insoluble exopolymer surrounding the cell mass thereby necessitating an unexpectedly high dissolved oxygen concentration for maximal productivity. The requirement for high volumetric oxygen transfer can be met by low shear designs with axial-flow impellers, providing gas dispersion is assisted by the use of sparging devices consisting of microporous materials.

  15. Preparation design and considerations for direct posterior composite inlay/onlay restoration.

    Fligor, Jason


    In order to ensure a functional, aesthetic, and long-lasting porcelain result, clinicians need to anticipate the strengths and limits of the restorative material, as well as the specific requisites of the presented case. As flaws in preparation design can have significant and detrimental effects on the final result, clinical comprehension of the dimensions and limitations during this step is of utmost importance. This article discusses a case presentation in which porcelain restorations were placed for two adjacent teeth. Although the clinician anticipated placing inlay or onlay restorations, the degree of decay and the location of hairline fractures would necessitate prophylactic removal of a weakened or undermined cusp.

  16. Air Distribution in a Room and Design Considerations of Mixing Ventilation by Flow Elements

    Nielsen, Peter V.; Jensen, Rasmus Lund; Pedersen, D. N.


    The paper shows detailed measurements of the air distribution in a room ventilated by mixing ventilation according to the specifications given by the International Energy Agency work. (Energy Conservation in Buildings and Community Systems Programme, Annex 20). It describes a number of flow...... elements and how they are used as design tools. The flow elements are the throw of an isothermal jet and the change in jet velocity when the jet moves from the upper to the lower part of the room. A third flow element is the penetration length of a non-isothermal wall jet....

  17. Training aircraft design considerations based on the successive organization of perception in manual control

    Heffley, R. K.; Clement, W. F.; Craig, S. J.


    The thesis that pilot skill development in the Navy approach and landing task is very strongly tied to the aircraft closure rate and, therefore, that pilot training for this task should be based on an appropriate progression closure rate is considered. A rational and explicit determination of design point approach speeds as well as other important aerodynamic features for training aircraft is also considered. Two keys are discussed: recognition of the significance of transitioning from a purely compensatory control loop technique to one involving a pursuit crossfeed between throttle and pitch attitude, and addressing the terminal flight path adjustment in terms of range-to-go.

  18. Rain fade in Ku-band VSAT networks - A design consideration

    Raust, Eric H.

    The components of a Very Small Aperture Terminal (VSAT) network are shown to determine the effect that rainfall has on Ku-band satellite communications. This paper considers the effect of the signal attenuation caused by rain as predicted by a well known rain fade model. The result, of considering the highest rain attenuations experienced is related to both transmission availabilities and signal margins. The results of link calculations are tabulated for typical network designs. These results show that proper selection of the VSAT's components and the satellite transponder power can all but eliminate rain outages while maintaining the economics of a Ku-band VSAT network.

  19. Design considerations of the irradiation test vehicle for the advanced test reactor

    Tsai, H.; Gomes, I.C.; Smith, D.L. [Argonne National Lab., IL (United States)] [and others


    An irradiation test vehicle (ITV) for the Advanced Test Reactor (ATR) is being jointly developed by the Lockheed Martin Idaho Technologies Company (LMIT) and the U.S. Fusion Program. The vehicle is intended for neutron irradiation testing of candidate structural materials, including vanadium-based alloys, silicon carbide composites, and low activation steels. It could possibly be used for U.S./Japanese collaboration in the Jupiter Program. The first test train is scheduled to be completed by September 1998. In this report, we present the functional requirements for the vehicle and a preliminary design that satisfies these requirements.

  20. Materials design considerations involved in the fabrication of implantable bionics by metallization of ceramic substrates.

    Patel, Sunil; Guenther, Thomas; Dodds, Christopher W D; Kolke, Sergej; Privat, Karen L; Matteucci, Paul B; Suaning, Gregg J


    The Pt metallization of co-fired Al2O3/SiO2 substrates containing Pt feedthroughs was shown to be a suitable means to construct implantable bionics. The use of forge welding to join an electrode to such a metallized feedthrough was demonstrated and subsequently evaluated through the use of metallography and electron microscopy. Metallurgical phenomena involved in forge welding relevant to the fabrication of all types of biomedical implants are discussed within this paper. The affect of thermal profiles used in brazing or welding to build implantable devices from metal components is analysed and the case for considered selection of alloys in implant design is put forward.


    Giuca Simona-Mihaela


    Full Text Available The current paper has the aim to provide guidelines for designing efficient product and price strategies, through proposed business cases which could be used especially for banking products addressed to SMEs. While identifying the optimal product and price strategy and designing the product catalogue structure, the marketing specialist should definitely consider existing portfolio behaviour and estimate the growing potential (if possible, overall portfolio, with focus on accurately defining the additional impact of the newly proposed product/ products. A business case contains estimations for results to be generated by products to be launched or optimized. This paper presents complex schemes for business case scenarios for migration of existing portfolio to the new products, but also considers new clients acquisition based on important features of the products. The pricing strategy is not a simple task to manage. Especially when speaking about transactional packages (for which the price is lower than separate services included, some segments or clusters may generate loss to the bank if they already used the services at a higher price than the one of the package. Therefore, the decision of setting up specific prices needs to be based on an accurate and complex analysis, as presented in current paper. The assumptions used in a business case need to be relevant for the entire process of designing and launching a product, therefore they can always be adjusted for better calculation of the impact. No matter if the assumptions and prices remain as in the initial proposal or not, the steps to be followed are the same. Segmentation also plays an important role in designing the product strategy, since the target for a product or product catalogue can be represented by a segment, a sub segment or a cluster of many segments. Not always the initial segmentation represents the clustering for the product strategy. Sometimes, behaviour of existing clients

  2. Design Considerations for a Stopped-Rotor Cyclocopter for Venus Exploration

    Husseyin, S.; Warmbrodt, William G.


    This paper considers the use of a cycloidal blade system as a means of providing lift and propulsive thrust as well as combined with a stopped rotor system, to create a stopped-rotor cyclocopter vehicle, during a mission to Venus. This stopped-rotor cyclocopter will be capable of flying at all atmospheric levels of Venus as well as landing on the surface for scientific investigation. Three reference conceptual designs with different stopped-rotor cyclocopter yaw angles are tested in RotCFD as well as a model of a hovering cyclorotor for comparison with past work in the literature and innovative study for future projects.

  3. Design Considerations of an Active Integrated Antenna with Negative Resistance Transistor Oscillator

    J. Bartolic


    Full Text Available The design of an active integrated antenna with negative resistancetransistor oscillator has been described. Simple but reasonablyaccurate analysis of oscillation start-up and steady state operatingfrequency prediction is presented. The active antenna prototype wasmanufactured and its operating frequency, EIRP and radiation patternswere measured. Two of these antennas were integrated in active arrayscoupled in E- and H-planes. The inter-element distance in the arrayswas optimized to obtain in-phase operation and mutual injectionlocking. Very good power combining efficiency was measured and beamscanning capabilities were demonstrated for both arrays.

  4. Geomechanical Analysis and Design Considerations for Thin-Bedded Salt Caverns

    Michael S. Bruno


    The bedded salt formations located throughout the United States are layered and interspersed with non-salt materials such as anhydrite, shale, dolomite and limestone. The salt layers often contain significant impurities. GRI and DOE have initialized this research proposal in order to increase the gas storage capabilities by providing operators with improved geotechnical design and operating guidelines for thin bedded salt caverns. Terralog has summarized the geologic conditions, pressure conditions, and critical design factors that may lead to: (1) Fracture in heterogeneous materials; (2) Differential deformation and bedding plane slip; (3) Propagation of damage around single and multiple cavern; and (4) Improved design recommendations for single and multiple cavern configurations in various bedded salt environments. The existing caverns within both the Permian Basin Complex and the Michigan and Appalachian Basins are normally found between 300 m to 1,000 m (1,000 ft to 3,300 ft) depth depending on local geology and salt dissolution depth. Currently, active cavern operations are found in the Midland and Anadarko Basins within the Permian Basin Complex and in the Appalachian and Michigan Basins. The Palo Duro and Delaware Basins within the Permian Basin Complex also offer salt cavern development potential. Terralog developed a number of numerical models for caverns located in thin bedded salt. A modified creep viscoplastic model has been developed and implemented in Flac3D to simulate the response of salt at the Permian, Michigan and Appalachian Basins. The formulation of the viscoplastic salt model, which is based on an empirical creep law developed for Waste Isolation Pilot Plant (WIPP) Program, is combined with the Drucker-Prager model to include the formation of damage and failure. The Permian salt lab test data provided by Pfeifle et al. 1983, are used to validate the assumptions made in the material model development. For the actual cavern simulations two

  5. Small UAV Automatic Ground Collision Avoidance System Design Considerations and Flight Test Results

    Sorokowski, Paul; Skoog, Mark; Burrows, Scott; Thomas, SaraKatie


    The National Aeronautics and Space Administration (NASA) Armstrong Flight Research Center Small Unmanned Aerial Vehicle (SUAV) Automatic Ground Collision Avoidance System (Auto GCAS) project demonstrated several important collision avoidance technologies. First, the SUAV Auto GCAS design included capabilities to take advantage of terrain avoidance maneuvers flying turns to either side as well as straight over terrain. Second, the design also included innovative digital elevation model (DEM) scanning methods. The combination of multi-trajectory options and new scanning methods demonstrated the ability to reduce the nuisance potential of the SUAV while maintaining robust terrain avoidance. Third, the Auto GCAS algorithms were hosted on the processor inside a smartphone, providing a lightweight hardware configuration for use in either the ground control station or on board the test aircraft. Finally, compression of DEM data for the entire Earth and successful hosting of that data on the smartphone was demonstrated. The SUAV Auto GCAS project demonstrated that together these methods and technologies have the potential to dramatically reduce the number of controlled flight into terrain mishaps across a wide range of aviation platforms with similar capabilities including UAVs, general aviation aircraft, helicopters, and model aircraft.

  6. Optical Design Considerations for Efficient Light Collection from Liquid Scintillation Counters

    Bernacki, Bruce E.; Douglas, Matthew; Erchinger, Jennifer L.; Fuller, Erin S.; Keillor, Martin E.; Morley, Shannon M.; Mullen, Crystal A.; Orrell, John L.; Panisko, Mark E.; Warren, Glen A.; Wright, Michael E.


    Liquid scintillation counters measure charged particle-emitting radioactive isotopes and are used for environmental studies, nuclear chemistry, and life science. Alpha and beta emissions arising from the material under study interact with the scintillation cocktail to produce light. The prototypical liquid scintillation counter employs low-level photon-counting detectors to measure the arrival of the scintillation light produced as a result of the dissolved material under study interacting with the scintillation cocktail. For reliable operation the counting instrument must convey the scintillation light to the detectors efficiently and predictably. Current best practices employ the use of two or more detectors for coincidence processing to discriminate true scintillation events from background events due to instrumental effects such as photomultiplier tube dark rates, tube flashing, or other light emission not generated in the scintillation cocktail vial. In low background liquid scintillation counters additional attention is paid to shielding the scintillation cocktail from naturally occurring radioactive material (NORM) present in the laboratory and within the instruments construction materials. Low background design is generally at odds with optimal light collection. This study presents the evolution of a light collection design for liquid scintillation counting in a low background shield. The basic approach to achieve both good light collection and a low background measurement is described. The baseline signals arising from the scintillation vial are modeled and methods to efficiently collect scintillation light are presented as part of the development of a customized low-background, high sensitivity liquid scintillation counting system.

  7. Client Perspectives on Desirable Attributes and Skills of Veterinary Technologists in Australia: Considerations for Curriculum Design.

    Clarke, Patricia M; Al-Alawneh, John; Pitt, Rachael E; Schull, Daniel N; Coleman, Glen T


    Client or service user perspectives are important when designing curricula for professional programs. In the case of veterinary technology, an emerging profession in the veterinary field in Australasia, client views on desirable graduate attributes, skills, and knowledge have not yet been explored. This study reports on a survey of 441 veterinary clients (with 104 responses) from four veterinary practices in Brisbane, Queensland, conducted between October 2008 and February 2009. The included veterinary practices provided clinical placements for veterinary technology undergraduates and employment for veterinary technology graduates (2003-2007). Client socio-demographic data along with ratings of the importance of a range of technical (veterinary nursing) skills, emotional intelligence, and professional attributes for veterinary technology graduates were collected and analyzed. Overall, the majority of clients viewed technical skills, emotional intelligence, and professional attributes as important in the clinical practice of veterinary technology graduates with whom they interacted in the veterinary practice. Client interviews (n=3) contextualized the survey data and also showed that clients attached importance to graduates demonstrating professional competence. Agglomerative hierarchical cluster analysis revealed four distinct groupings of clients within the data based on their differing perceptions. Using a multivariable proportional-odds regression model, it was also found that some client differences were influenced by demographic factors such as gender, age, and number of visits annually. For example, the odds of female clients valuing emotionality and sociability were greater than males. These findings provide useful data for the design of a professionalizing and market-driven veterinary technology curriculum.

  8. Thermo-structural analysis and design consideration of the replaceable backwall in IFMIF liquid lithium target

    Nakamura, H. [Japan Atomic Energy Agency, Tokai-mura, Ibaraki 319-1195 (Japan)]. E-mail:; Ida, M. [Japan Atomic Energy Agency, Tokai-mura, Ibaraki 319-1195 (Japan); Chida, T. [Japan Atomic Energy Agency, Tokai-mura, Ibaraki 319-1195 (Japan); Shiba, K. [Japan Atomic Energy Agency, Tokai-mura, Ibaraki 319-1195 (Japan); Shimizu, K. [Mitsubishi Heavy Industry, Hyogo 652-8585 (Japan); Sugimoto, M. [Japan Atomic Energy Agency, Tokai-mura, Ibaraki 319-1195 (Japan)


    The IFMIF is an accelerator-based intense neutron source for testing candidate materials for fusion reactors. Intense neutrons are emitted inside the Li flow through a backwall. The backwall made of 316L stainless steel or RAFM is attached to the target assembly with a lip seal welded by a YAG laser. Since the backwall is operating under a severe neutron irradiation of 50 dpa/year and a maximum nuclear heating rate of 25 W/cm{sup 3}, thermo-structural design is one of critical issues in a target design. Thermal stress was calculated using the ABAQUS code. As a permissible stress, yield strength at 300 {sup o}C was used. In the case of the 316 stainless steel backwall, the maximum thermal stress was more than the permissible stress (164 MPa). On the other hand, in case of the F82H backwall, a maximum thermal stress was below the permissible stress (455 MPa). Therefore, F82H is recommended as the backwall material.

  9. Design Considerations for the Installation of an Iodine (I2) Cell onto TRES

    Garcia-Mejia, Juliana


    The radial velocity (RV) method utilizes the reflex motion of a target star to predict the presence of one or multiple exoplanets. However, the disparity in mass between planet and host star often results in RV oscillations below the precision of most modern spectrographs. Such is the case of TRES, the Tillinghast Reflector Echelle Spectrograph located in the Fred Lawrence Whipple Observatory in Mt. Hopkins, Arizona, with a radial velocity (RV) precision of ~ 20 m s-1, dominated by instrumental effects. Since 1992, the iodine cell technique, presented in Butler et al.(1992) has become widely used for the reduction of RV measurement errors. Here, we describe the beginning stages in the installation of one such cell onto TRES. After traveling to the telescope site to perform the first fitting of the iodine stage, I designed, built and fitted the first prototype of an improved thermal insulation system for the front end of the spectrograph, where the cell will be mounted. Here I present such a design, as well as a detailed description of the current state of the project. We expect the iodine cell to be fully functional in approximately 1 year. Once the cell is installed, we expect errors in radial velocity measurements to decrease by an order of magnitude from the aforementioned 20 m s-1. This increase in precision will come with an increase in stability of radial velocity measurements, allowing TRES to perform in-house spectroscopy of more nearby bright targets and high-cadence exoplanet follow-up.

  10. Design Considerations of Biaxially Tensile-Strained Germanium-on-Silicon Lasers

    Li, Xiyue; Li, Simon; Chrostowski, Lukas; Guangrui,; Xia,


    Physical models of Ge energy band structure and material loss were implemented in LASTIP(TM), a 2D simulation tool for edge emitting laser diodes. The model calculation is able to match experimental data available. Important design parameters of a Fabry-Perot Ge laser, such as the cavity length, thickness, width, polycrystalline Si cladding layer thickness were studied and optimized. The laser structure optimizations were shown to reduce the threshold current by 22-fold. The simulations also showed that improving the defect limited carrier lifetime is critical for achieving an efficient and low-threshold Ge laser. With the optimized structure design (300 micron for the cavity length, 0.4 micron for the cavity width, 0.3 micron for the cavity thickness, and 0.6 micron for the polycrystalline Si cladding layer thickness) and a defect limited carrier lifetime of 100 ns, a wall-plug efficiency of 14.6% at 1mW output is predicted, where Jth of 2.8 kA/cm2, Ith of 3.3 mA, I_1mA of 9 mA, and differential efficiency o...

  11. Design consideration in constructing high performance embedded Knowledge-Based Systems (KBS)

    Dalton, Shelly D.; Daley, Philip C.


    As the hardware trends for artificial intelligence (AI) involve more and more complexity, the process of optimizing the computer system design for a particular problem will also increase in complexity. Space applications of knowledge based systems (KBS) will often require an ability to perform both numerically intensive vector computations and real time symbolic computations. Although parallel machines can theoretically achieve the speeds necessary for most of these problems, if the application itself is not highly parallel, the machine's power cannot be utilized. A scheme is presented which will provide the computer systems engineer with a tool for analyzing machines with various configurations of array, symbolic, scaler, and multiprocessors. High speed networks and interconnections make customized, distributed, intelligent systems feasible for the application of AI in space. The method presented can be used to optimize such AI system configurations and to make comparisons between existing computer systems. It is an open question whether or not, for a given mission requirement, a suitable computer system design can be constructed for any amount of money.

  12. Meristematic activity of the Endodermis and the Pericycle in the primary thickening in monocotyledons: considerations on the "PTM"

    Nanuza L. de Menezes


    Full Text Available This paper proposes a new interpretation for primary thickening in monocotyledons. The anatomy of the vegetative organs of the following species was examined: Cephalostemon riedelianus (Rapataceae, Cyperus papyrus (Cyperaceae, Lagenocarpus rigidus, L. junciformis (Cyperaceae, Echinodorus paniculatus (Alismataceae and Zingiber officinale (Zingiberaceae. The endodermis with meristematic activity was observed in the root of all the species, in the stem of Cyperus, Cephalostemum and Lagenocarpus rigidus, and in the leaf trace of Cyperus and leaf of Echinodorus. Considering the continuity of tissues through the root, stem and leaf, the authors conclude that in the stem the pericycle remains active throughout the life of the plant as the generator of the vascular tissue. The "Primary Thickening Meristem" is in fact the pericycle plus the endodermis and its derivatives (or only the pericycle. Close to the stem apex, the assemblage of seems to be a unique meristem, giving rise to the inner cortex and vascular tissues.A proposta deste trabalho é mostrar uma nova interpretação do meristema de espessamento primário em monocotiledôneas. Anatomia dos órgãos vegetativos das seguintes espécies foi examinada: Cephalostemon riedelianus (Rapataceae, Cyperus papyrus (Cyperaceae, Lagenocarpus rigidus, L. Junciformis (Cyperaceae, Echinodorus paniculatus (Alismataceae and Zingiberofficinale (Zingiberaceae. A atividade meristemática da endoderme foi observada nas raizes de todas as espécies, no caule de Cyperus, Cephalostemum e Lagenocarpus rigidus, e no traço foliar de Cyperus e folha de Echinodorus. Considerando a continuidade dos tecidos através da raiz, caule e folha, as autoras concluem que no caule o periciclo permanece ativo durante a vida da planta, como um gerador de tecidos vasculares. O "Meristema de Espessamento Primário" é o periciclo em fase meristemática, juntamente com a endoderme e suas derivadas (ou apenas o periciclo. Próximo ao

  13. Screening for psychological distress in adult primary brain tumor patients and caregivers: considerations for cancer care coordination

    Wafa eTrad


    Full Text Available IntroductionThis study aimed to assess psychological distress (PD as scored by the Distress Thermometer (DT in adult primary brain tumor (PBT patients and caregivers in a clinic setting, and ascertain if any high risk sub-groups for PD exist. Material and MethodsFrom May 2012 to August 2013, n=96 patients and n=32 caregivers (CG underwent DT screening at diagnosis, and a differing cohort of n=12 patients and n=14 caregivers at first recurrence. Groups were described by diagnosis (high grade, low grade and benign, and English versus non-English speaking. Those with DT score≥4 met caseness criteria for referral to psycho-oncology services. One-way ANOVA tests were conducted to test for between group differences where appropriate.ResultsAt diagnosis and first recurrence, 37.5% and 75.0% (respectively of patients had DT scores above the cut-off for distress. At diagnosis, 78.1% of caregivers met caseness criteria for distress. All caregivers at recurrence met distress criterion. Patients with high grade glioma had significantly higher scores than those with a benign tumor. For patients at diagnosis, non-English speaking participants did not report significantly higher DT scores than English speaking participants.DiscussionPsychological distress is particularly elevated in caregivers, and in patients with high grade glioma at diagnosis. Effective PD screening, triage and referral by skilled care coordinators is vital to enable timely needs assessment, psychological support and effective intervention.

  14. Design considerations for quasi-phase-matching in doubly resonant lithium niobate hexagonal micro-resonators

    Sono, Tleyane J.; Riziotis, Christos; Mailis, Sakellaris; Eason, Robert W.


    Fabrication capabilities of high optical quality hexagonal superstructures by chemical etching of inverted ferroelectric domains in lithium niobate platform suggests a route for efficient implementation of compact hexagonal microcavities. Such nonlinear optical hexagonal micro-resonators are proposed as a platform for second harmonic generation (SHG) by the combined mechanisms of total internal reflection (TIR) and quasi-phase-matching (QPM). The proposed scheme for SHG via TIR-QPM in a hexagonal microcavity can improve the efficiency and also the compactness of SHG devices compared to traditional linear-type based devices. A simple theoretical model based on six-bounce trajectory and phase matching conditions was capable for obtaining the optimal cavity size. Furthermore numerical simulation results based on finite difference time domain beam propagation method analysis confirmed the solutions obtained by demonstrating resonant operation of the microcavity for the second harmonic wave produced by TIR-QPM. Design aspects, optimization issues and characteristics of the proposed nonlinear device are presented.

  15. Design Considerations for Autocalibrations of Wide-Band ΔΣ Fractional-N PLL Synthesizers

    Jaewook Shin


    Full Text Available Autocalibration of VCO frequency and loop gain is an essential process in PLL frequency synthesizers. In a wide tuning-range fractional-N PLL frequency synthesizer, high-speed and high-precision automatic calibration is especially important for shortening the lock time and improving the phase noise. This paper reviews the design issues of the PLL auto-calibration and discusses on the limitations of the previous techniques. A very simple and efficient auto-calibration method based on a high-speed frequency-to-digital converter (FDC is proposed and verified through simulations. The proposed method is highly suited for a very wide-band ΔΣ fractional-N PLL.

  16. Considerations for Ship Design and Forensics Based Upon Modern Advances in Nonlinear Waves

    Osborne, Alfred


    My recent activities for Nonlinear Waves Research Corporation have lead to a number of new advances in ocean surface waves that have been applied to the reanalysis and forensics of sunken ships. The methods are based upon progress in the physical understanding of ocean waves and have required a number of breakthroughs requiring applications of algebraic geometry, topology and differential geometry. This work has provided a number of new tools for the forecasting/hindcasting of wind waves (including the prediction of rogue waves), for the deterministic simulation of ocean waves (including both the Type I and Type II instabilities) and for the statistical behavior of ocean waves. These approaches have lead to procedures for the determination of the design wave for ships and for the forensics of sunken ships in past storms. I give examples of how these approaches have been applied.

  17. Design considerations for a fiber optic communications network for power systems

    Kirkham, H.; Johnston, A.R. [Jet Propulsion Lab., Pasadena, CA (United States); Allen, G.D. [American Electric Power Service Corp., Columbus, OH (United States)


    The design of a fiber optic communication network for monitoring and control in power systems is discussed. It is shown that by appropriate choice of protocols, a fault-tolerant system can be built that operates in any arbitrary configuration. Since the network is based on fiber optics, it can be made fast enough for substation monitoring and control. In this application, a relatively small number of cables is required to implement a high reliability system. The network can also be used for distribution automation. In this application the network is required to reach all parts of the power system, and the fiber cable itself becomes a significant fraction of the cost of communications. However, since many applications can be supported at once, the cost per function can be reasonable.

  18. Investigation of beam window buckling with consideration of irradiation effects for conceptual ADS design

    Sugawara, Takanori, E-mail: sugawara.takanori@jaea.go.j [Japan Atomic Energy Agency, Shirakata Shirane 2-4, Tokai-mura, Naka-gun, Ibaraki, 319-1195 (Japan); Kikuchi, Kenji; Nishihara, Kenji; Oigawa, Hiroyuki [Japan Atomic Energy Agency, Shirakata Shirane 2-4, Tokai-mura, Naka-gun, Ibaraki, 319-1195 (Japan)


    The investigation of the beam window, which is a key component in the conceptual design of an Accelerator Driven System, has been performed. In the past studies, it was found that buckling failure due to hydrostatic pressure in the liquid lead bismuth was critical failure mode for the beam window and detailed structural analyses were performed. These investigations, however, did not consider irradiation effects by neutrons and protons. In this study, investigations based on the latest knowledge for irradiation effects obtained in the spallation target irradiation program are presented. By using the experimental data, it was found that the buckling pressure increased about 80% by the irradiation (20 dpa). It was assumed that if the beam window had integrity in the unirradiated condition, the buckling failure would not be critical issue during the ADS operation.

  19. Audio Key Finding: Considerations in System Design and Case Studies on Chopin's 24 Preludes

    Chuan, Ching-Hua; Chew, Elaine


    We systematically analyze audio key finding to determine factors important to system design, and the selection and evaluation of solutions. First, we present a basic system, fuzzy analysis spiral array center of effect generator algorithm, with three key determination policies: nearest-neighbor (NN), relative distance (RD), and average distance (AD). AD achieved a 79% accuracy rate in an evaluation on 410 classical pieces, more than 8% higher RD and NN. We show why audio key finding sometimes outperforms symbolic key finding. We next propose three extensions to the basic key finding system—the modified spiral array (mSA), fundamental frequency identification (F0), and post-weight balancing (PWB)—to improve performance, with evaluations using Chopin's Preludes (Romantic repertoire was the most challenging). F0 provided the greatest improvement in the first 8 seconds, while mSA gave the best performance after 8 seconds. Case studies examine when all systems were correct, or all incorrect.

  20. Design considerations for the coherent radiator, FEL, in the MAX IV proposal

    Werin, Sverker; Brandin, Mathias; Eriksson, Mikael; Hansen, T N; Larsson, Jörgen; Lindgren, L J; Tarawneh, Hamed


    The MAX IV proposal is a project for the next Swedish synchrotron radiation source. Currently a design study is produced with funding from the Swedish research council (VR). One half of the project will be a double storage ring (at 3 and 1.5 GeV respectively) but the other half will be a coherent radiator, FEL, based on the 3 GeV injector. The basic FEL solution will consist of a normal conducting linac at 3 GeV which feeds three seeded cascaded optical klystrons and a radiator undulator to produce radiation down to 1.5-3 nm at GW powers. To assure synchronisation the gun laser and the seed laser share initial laser and amplifier. This basic system can be enhanced in various ways which will be discussed .


    Drake, R. P. [Department of Atmospheric, Oceanic, and Space Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Gregori, G., E-mail: [Department of Physics, University of Oxford, Parks Road, Oxford OX1 3PU (United Kingdom)


    The subject of this paper is the design of practical laser experiments that can produce collisionless shocks mediated by the Weibel instability. Such shocks may be important in a wide range of astrophysical systems. Three issues are considered. The first issue is the implications of the fact that such experiments will produce expanding flows that are approximately homologous. As a result, both the velocity and the density of the interpenetrating plasma streams will be time dependent. The second issue is the implications of the linear theory of the Weibel instability. For the experiments, the instability is in a regime where standard simplifications do not apply. It appears feasible but non-trivial to obtain adequate growth. The third issue is collisionality. The need to keep resistive magnetic-field dissipation small enough implies that the plasmas should not be allowed to cool substantially.

  2. Size effect in composite materials and structures: Basic concepts and design considerations

    Zweben, Carl


    Composite materials display strength characteristics that are similar to those of brittle ceramics, whose strengths are known to decrease with increasing volume for a uniform state of stress (size effect) and also are dependent on stress distribution. These similarities raise the question of whether there is also a size effect in composite materials and structures. There is significant, but inconclusive experimental evidence for the existence of a size effect in composites. Macroscopic and micromechanical statistical models have been developed which predict a size effect and are in general agreement with experimental data. The existence of a significant size effect in composites would be of great importance. For example, it would mean that use of standard test coupons to establish design allowables for large structures could be very nonconservative. Further, it would be necessary to analyze the strength of large composite structures using statistical methods, as is done for ceramics.

  3. Guide to radiological accident considerations for siting and design of DOE nonreactor nuclear facilities

    Elder, J.C.; Graf, J.M.; Dewart, J.M.; Buhl, T.E.; Wenzel, W.J.; Walker, L.J.; Stoker, A.K.


    This guide was prepared to provide the experienced safety analyst with accident analysis guidance in greater detail than is possible in Department of Energy (DOE) Orders. The guide addresses analysis of postulated serious accidents considered in the siting and selection of major design features of DOE nuclear facilities. Its scope has been limited to radiological accidents at nonreactor nuclear facilities. The analysis steps addressed in the guide lead to evaluation of radiological dose to exposed persons for comparison with siting guideline doses. Other possible consequences considered are environmental contamination, population dose, and public health effects. Choices of models and parameters leading to estimation of source terms, release fractions, reduction and removal factors, dispersion and dose factors are discussed. Although requirements for risk analysis have not been established, risk estimates are finding increased use in siting of major nuclear facilities, and are discussed in the guide. 3 figs., 9 tabs.

  4. Design considerations for a 10-kW integrated hydrogen-oxygen regenerative fuel cell system

    Hoberecht, M. A.; Miller, T. B.; Rieker, L. L.; Gonzalez-Sanabria, O. D.


    Integration of an alkaline fuel cell subsystem with an alkaline electrolysis subsystem to form a regenerative fuel cell (RFC) system for low earth orbit (LEO) applications characterized by relatively high overall round trip electrical efficiency, long life, and high reliability is possible with present state of the art technology. A hypothetical 10 kW system computer modeled and studied based on data from ongoing contractual efforts in both the alkaline fuel cell and alkaline water electrolysis areas. The alkaline fuel cell technology is under development utilizing advanced cell components and standard Shuttle Orbiter system hardware. The alkaline electrolysis technology uses a static water vapor feed technique and scaled up cell hardware is developed. The computer aided study of the performance, operating, and design parameters of the hypothetical system is addressed.

  5. Development of the Database for Environmental Sound Research and Application (DESRA: Design, Functionality, and Retrieval Considerations

    Brian Gygi


    Full Text Available Theoretical and applied environmental sounds research is gaining prominence but progress has been hampered by the lack of a comprehensive, high quality, accessible database of environmental sounds. An ongoing project to develop such a resource is described, which is based upon experimental evidence as to the way we listen to sounds in the world. The database will include a large number of sounds produced by different sound sources, with a thorough background for each sound file, including experimentally obtained perceptual data. In this way DESRA can contain a wide variety of acoustic, contextual, semantic, and behavioral information related to an individual sound. It will be accessible on the Internet and will be useful to researchers, engineers, sound designers, and musicians.

  6. Audio Key Finding: Considerations in System Design and Case Studies on Chopin's 24 Preludes

    Elaine Chew


    Full Text Available We systematically analyze audio key finding to determine factors important to system design, and the selection and evaluation of solutions. First, we present a basic system, fuzzy analysis spiral array center of effect generator algorithm, with three key determination policies: nearest-neighbor (NN, relative distance (RD, and average distance (AD. AD achieved a 79% accuracy rate in an evaluation on 410 classical pieces, more than 8% higher RD and NN. We show why audio key finding sometimes outperforms symbolic key finding. We next propose three extensions to the basic key finding system—the modified spiral array (mSA, fundamental frequency identification (F0, and post-weight balancing (PWB—to improve performance, with evaluations using Chopin's Preludes (Romantic repertoire was the most challenging. F0 provided the greatest improvement in the first 8 seconds, while mSA gave the best performance after 8 seconds. Case studies examine when all systems were correct, or all incorrect.

  7. Joint Channel Assignment and Routing in Multiradio Multichannel Wireless Mesh Networks: Design Considerations and Approaches

    Omar M. Zakaria


    Full Text Available Multiradio wireless mesh network is a promising architecture that improves the network capacity by exploiting multiple radio channels concurrently. Channel assignment and routing are underlying challenges in multiradio architectures since both determine the traffic distribution over links and channels. The interdependency between channel assignments and routing promotes toward the joint solutions for efficient configurations. This paper presents an in-depth review of the joint approaches of channel assignment and routing in multiradio wireless mesh networks. First, the key design issues, modeling, and approaches are identified and discussed. Second, existing algorithms for joint channel assignment and routing are presented and classified based on the channel assignment types. Furthermore, the set of reconfiguration algorithms to adapt the network traffic dynamics is also discussed. Finally, the paper presents some multiradio practical implementations and test-beds and points out the future research directions.

  8. Design considerations for multi-core optical fibers in nonlinear switching and mode-locking applications

    Nazemosadat, Elham


    We explore the practical challenges which should be addressed when designing a multi-core fiber coupler for nonlinear switching or mode-locking applications. The inevitable geometric imperfections formed in these fiber couplers during the fabrication process affect the performance characteristics of the nonlinear switching device. Fabrication uncertainties are tolerable as long as the changes they impose on the propagation constant of the modes are smaller than the linear coupling between the cores. It is possible to reduce the effect of the propagation constant variations by bringing the cores closer to each other, hence, increasing the coupling. However, higher coupling translates into a higher switching power which may not be desirable in some practical situations. Therefore, fabrication errors limit the minimum achievable switching power in nonlinear couplers.

  9. Implementing a pilot leadership course for internal medicine residents: design considerations, participant impressions, and lessons learned.

    Blumenthal, Daniel M; Bernard, Ken; Fraser, Traci N; Bohnen, Jordan; Zeidman, Jessica; Stone, Valerie E


    Effective clinical leadership is associated with better patient care. We implemented and evaluated a pilot clinical leadership course for second year internal medicine residents at a large United States Academic Medical Center that is part of a multi-hospital health system. The course met weekly for two to three hours during July, 2013. Sessions included large group discussions and small group reflection meetings. Topics included leadership styles, emotional intelligence, and leading clinical teams. Course materials were designed internally and featured "business school style" case studies about everyday clinical medicine which explore how leadership skills impact care delivery. Participants evaluated the course's impact and quality using a post-course survey. Questions were structured in five point likert scale and free text format. Likert scale responses were converted to a 1-5 scale (1 = strongly disagree; 3 = neither agree nor disagree; 5 = strongly agree), and means were compared to the value 3 using one-way T-tests. Responses to free text questions were analyzed using the constant comparative method. All sixteen pilot course participants completed the survey. Participants overwhelmingly agreed that the course provided content and skills relevant to their clinical responsibilities and leadership roles. Most participants also acknowledged that taking the course improved their understanding of their strengths and weaknesses as leaders, different leadership styles, and how to manage interpersonal conflict on clinical teams. 88% also reported that the course increased their interest in pursuing additional leadership training. A clinical leadership course for internal medicine residents designed by colleagues, and utilizing case studies about clinical medicine, resulted in significant self-reported improvements in clinical leadership competencies.

  10. Consideration of hazardous and especially hazardous hydrometeorological impacts in design of buildings and structures of nuclear power plants

    Bryukhan Fedor


    Full Text Available External impacts of the hydrometeorological origin have a significant influence on the safety level of objects of use of atomic energy (OUAE, including nuclear power plants (NPP. Therefore, the existing NPP-related safety regulations demand to consider such impacts at all stages of the NPP life cycle. It is important to make decisions on considering or ignoring certain external impacts while designing NPP buildings and structures. The main criterion for such decisions is the probability of a non-project accident associated with the release of radionuclides into the environment when an extreme phenomena occurs. The aim of this study is to develop a concept for refinement regulatory requirements, considering hydrometeorological factors in organization of NPP engineering protection. Criteria for consideration of hazardous and especially hazardous hydrometeorological impacts for design of NPP buildings and structures were analyzed, and recommendations for refinement of regulatory requirements, considering hydrometeorological factors in organization of NPP engineering protection, were developed.

  11. Consideration of alternative designs for a Percutaneous Endoscopic Gastrostomy feeding tube

    Yerrabolu, Santosh Rohit

    The inability of some people to chew or swallow foods (but can digest foods) due to problems associated with various diseases and complications leads them to insufficient nutritional intake and loss of quality of life. These individuals are generally provided with nutritional support by means of injecting or infusing food directly into their stomachs or small intestines via feeding tubes. Gastrostomy feeding tubes (G-tubes) are used when such nutritional support is required for over 3-6 weeks. Percutaneous Endoscopic Gastrostomy (PEG) tubes are one of the most widely used G- Tubes and devices which are inserted via an incision through the abdominal wall either through a pull or push method. This investigation proposes conceptual alternative Percutaneous Endoscopy Gastrostomy (PEG) feeding tube designs with optimized materials selection to be used for their construction. The candidate materials were chosen from 18 commercial catheters, 2 reference grade polymers and a commercial polymer; using tissue-catheter-friction testing and surface chemistry characterization (Infrared spectroscopy and Critical Surface Tension approximation). The main objectives considered were to minimize slipping/dislodgement of gastrostomy tube/seal, to reduce peristomal leakage, and to attain size variability of PEG tubes while maintaining a low profile. Scanning Electron Microscope- Energy Dispersive X-ray Spectroscopy was employed to further determine the filler materials used in the samples. Nylon coated with fatty ester and filled with Barium sulphate was determined as the optimum material for the construction of the tube part of the feeding tubes to reduce slipping/dislodgment of gastrostomy tube/seal and to minimize peristomal leakage. Nylon coated with fatty ester and filled with Silica is the suggested as a candidate material for construction of the bumper/mushroom sections of the feeding tubes to avoid the Buried Bumper Syndrome. Fused Deposition Modeling, Selective Laser Sintering

  12. Finite-size scaling in silver nanowire films: design considerations for practical devices

    Large, Matthew J.; Cann, Maria; Ogilvie, Sean P.; King, Alice A. K.; Jurewicz, Izabela; Dalton, Alan B.


    We report the first application of finite-size scaling theory to nanostructured percolating networks, using silver nanowire (AgNW) films as a model system for experiment and simulation. AgNWs have been shown to be a prime candidate for replacing Indium Tin Oxide (ITO) in applications such as capacitive touch sensing. While their performance as large area films is well-studied, the production of working devices involves patterning of the films to produce isolated electrode structures, which exhibit finite-size scaling when these features are sufficiently small. We demonstrate a generalised method for understanding this behaviour in practical rod percolation systems, such as AgNW films, and study the effect of systematic variation of the length distribution of the percolating material. We derive a design rule for the minimum viable feature size in a device pattern, relating it to parameters which can be derived from a transmittance-sheet resistance data series for the material in question. This understanding has direct implications for the industrial adoption of silver nanowire electrodes in applications where small features are required including single-layer capacitive touch sensors, LCD and OLED display panels.We report the first application of finite-size scaling theory to nanostructured percolating networks, using silver nanowire (AgNW) films as a model system for experiment and simulation. AgNWs have been shown to be a prime candidate for replacing Indium Tin Oxide (ITO) in applications such as capacitive touch sensing. While their performance as large area films is well-studied, the production of working devices involves patterning of the films to produce isolated electrode structures, which exhibit finite-size scaling when these features are sufficiently small. We demonstrate a generalised method for understanding this behaviour in practical rod percolation systems, such as AgNW films, and study the effect of systematic variation of the length distribution of

  13. ULE design considerations for a 3m class light weighted mirror blank for E-ELT M5

    Fox, Andrew; Hobbs, Tom; Edwards, Mary; Arnold, Matthew; Sawyer, Kent


    It is expected that the next generation of large ground based astronomical telescopes will need large fast-steering/tip-tilt mirrors made of ultra-lightweight construction. These fast-steering mirrors are used to continuously correct for atmospheric disturbances and telescope vibrations. An example of this is the European Extremely Large Telescope (E-ELT) M5 lightweight mirror, which is part of the Tip-Tilt/Field-Stabilization Unit. The baseline design for the E-ELT M5 mirror, as presented in the E-ELT Construction Proposal, is a closed-back ULE mirror with a lightweight core using square core cells. Corning Incorporated (Corning) has a long history of manufacturing lightweight mirror blanks using ULE in a closed-back construction, going back to the 1960's, and includes the Hubble Space Telescope primary mirror, Subaru Telescope secondary and tertiary mirrors, the Magellan I and II tertiary mirrors, and Kepler Space Telescope primary mirror, among many others. A parametric study of 1-meter class lightweight mirror designs showed that Corning's capability to seal a continuous back sheet to a light-weighted core structure provides superior mirror rigidity, in a near-zero thermal expansion material, relative to other existing technologies in this design space. Corning has investigated the parametric performance of several design characteristics for a 3-meter class lightweight mirror blank for the E-ELT M5. Finite Element Analysis was performed on several design scenarios to obtain weight, areal density, and first Eigen frequency. This paper presents an overview of Corning ULE and lightweight mirror manufacturing capabilities, the parametric performance of design characteristics for 1-meter class and 3-meter class lightweight mirrors, as well as the manufacturing advantages and disadvantages of those characteristics.

  14. Design and methodological considerations of an effectiveness trial of a computer-assisted intervention: an example from the NIDA Clinical Trials Network.

    Campbell, Aimee N C; Nunes, Edward V; Miele, Gloria M; Matthews, Abigail; Polsky, Daniel; Ghitza, Udi E; Turrigiano, Eva; Bailey, Genie L; VanVeldhuisen, Paul; Chapdelaine, Rita; Froias, Autumn; Stitzer, Maxine L; Carroll, Kathleen M; Winhusen, Theresa; Clingerman, Sara; Perez, Livangelie; McClure, Erin; Goldman, Bruce; Crowell, A Rebecca


    Computer-assisted interventions hold the promise of minimizing two problems that are ubiquitous in substance abuse treatment: the lack of ready access to treatment and the challenges to providing empirically-supported treatments. Reviews of research on computer-assisted treatments for mental health and substance abuse report promising findings, but study quality and methodological limitations remain an issue. In addition, relatively few computer-assisted treatments have been tested among illicit substance users. This manuscript describes the methodological considerations of a multi-site effectiveness trial conducted within the National Institute on Drug Abuse's (NIDA's) National Drug Abuse Treatment Clinical Trials Network (CTN). The study is evaluating a web-based version of the Community Reinforcement Approach, in addition to prize-based contingency management, among 500 participants enrolled in 10 outpatient substance abuse treatment programs. Several potential effectiveness trial designs were considered and the rationale for the choice of design in this study is described. The study uses a randomized controlled design (with independent treatment arm allocation), intention-to-treat primary outcome analysis, biological markers for the primary outcome of abstinence, long-term follow-up assessments, precise measurement of intervention dose, and a cost-effectiveness analysis. Input from community providers during protocol development highlighted potential concerns and helped to address issues of practicality and feasibility. Collaboration between providers and investigators supports the utility of infrastructures that enhance research partnerships to facilitate effectiveness trials and dissemination of promising, technologically innovative treatments. Outcomes from this study will further the empirical knowledge base on the effectiveness and cost-effectiveness of computer-assisted treatment in clinical treatment settings.

  15. Design Considerations for Ceramic Matrix Composite Vanes for High Pressure Turbine Applications

    Boyle, Robert J.; Parikh, Ankur H.; Nagpal, Vinod K.; Halbig, Michael C.


    Issues associated with replacing conventional metallic vanes with Ceramic Matrix Composite (CMC) vanes in the first stage of the High Pressure Turbine (HPT) are explored. CMC materials have higher temperature capability than conventional HPT vanes, and less vane cooling is required. The benefits of less vane coolant are less NOx production and improved vane efficiency. Comparisons between CMC and metal vanes are made at current rotor inlet temperatures and at an vane inlet pressure of 50 atm.. CMC materials have directionally dependent strength characteristics, and vane designs must accommodate these characteristics. The benefits of reduced NOx and improved cycle efficiency obtainable from using CMC vanes. are quantified Results are given for vane shapes made of a two dimensional CMC weave. Stress components due to thermal and pressure loads are shown for all configurations. The effects on stresses of: (1) a rib connecting vane pressure and suction surfaces; (2) variation in wall thickness; and (3) trailing edge region cooling options are discussed. The approach used to obtain vane temperature distributions is discussed. Film cooling and trailing edge ejection were required to avoid excessive vane material temperature gradients. Stresses due to temperature gradients are sometimes compressive in regions where pressure loads result in high tensile stresses.

  16. Timing-Error Detection Design Considerations in Subthreshold: An 8-bit Microprocessor in 65 nm CMOS

    Lauri Koskinen


    Full Text Available This paper presents the first known timing-error detection (TED microprocessor able to operate in subthreshold. Since the minimum energy point (MEP of static CMOS logic is in subthreshold, there is a strong motivation to design ultra-low-power systems that can operate in this region. However, exponential dependencies in subthreshold, require systems with either excessively large safety margins or that utilize adaptive techniques. Typically, these techniques include replica paths, sensors, or TED. Each of these methods adds system complexity, area, and energy overhead. As a run-time technique, TED is the only method that accounts for both local and global variations. The microprocessor presented in this paper utilizes adaptable error-detection sequential (EDS circuits that can adjust to process and environmental variations. The results demonstrate the feasibility of the microprocessor, as well as energy savings up to 28%, when using the TED method in subthreshold. The microprocessor is an 8-bit core, which is compatible with a commercial microcontroller. The microprocessor is fabricated in 65 nm CMOS, uses as low as 4.35 pJ/instruction, occupies an area of 50,000 μm2, and operates down to 300 mV.

  17. Design considerations for case series models with exposure onset measurement error.

    Mohammed, Sandra M; Dalrymple, Lorien S; Sentürk, Damla; Nguyen, Danh V


    The case series model allows for estimation of the relative incidence of events, such as cardiovascular events, within a pre-specified time window after an exposure, such as an infection. The method requires only cases (individuals with events) and controls for all fixed/time-invariant confounders. The measurement error case series model extends the original case series model to handle imperfect data, where the timing of an infection (exposure) is not known precisely. In this work, we propose a method for power/sample size determination for the measurement error case series model. Extensive simulation studies are used to assess the accuracy of the proposed sample size formulas. We also examine the magnitude of the relative loss of power due to exposure onset measurement error, compared with the ideal situation where the time of exposure is measured precisely. To facilitate the design of case series studies, we provide publicly available web-based tools for determining power/sample size for both the measurement error case series model as well as the standard case series model.

  18. Design considerations for pulsed-flow comprehensive two-dimensional GC: dynamic flow model approach.

    Harvey, Paul McA; Shellie, Robert A; Haddad, Paul R


    A dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GCxGC) system is described. The dynamic flow model assists design of a PFM-GCxGC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GCxGC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GCxGC system. The flexibility of a PFM-GCxGC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods.

  19. Biomechanical Considerations in the Design of High-Flexion Total Knee Replacements

    Cheng-Kung Cheng


    Full Text Available Typically, joint arthroplasty is performed to relieve pain and improve functionality in a diseased or damaged joint. Total knee arthroplasty (TKA involves replacing the entire knee joint, both femoral and tibial surfaces, with anatomically shaped artificial components in the hope of regaining normal joint function and permitting a full range of knee flexion. In spite of the design of the prosthesis itself, the degree of flexion attainable following TKA depends on a variety of factors, such as the joint’s preoperative condition/flexion, muscle strength, and surgical technique. High-flexion knee prostheses have been developed to accommodate movements that require greater flexion than typically achievable with conventional TKA; such high flexion is especially prevalent in Asian cultures. Recently, computational techniques have been widely used for evaluating the functionality of knee prostheses and for improving biomechanical performance. To offer a better understanding of the development and evaluation techniques currently available, this paper aims to review some of the latest trends in the simulation of high-flexion knee prostheses.

  20. Statistical considerations of optimal study design for human plasma proteomics and biomarker discovery.

    Zhou, Cong; Simpson, Kathryn L; Lancashire, Lee J; Walker, Michael J; Dawson, Martin J; Unwin, Richard D; Rembielak, Agata; Price, Patricia; West, Catharine; Dive, Caroline; Whetton, Anthony D


    A mass spectrometry-based plasma biomarker discovery workflow was developed to facilitate biomarker discovery. Plasma from either healthy volunteers or patients with pancreatic cancer was 8-plex iTRAQ labeled, fractionated by 2-dimensional reversed phase chromatography and subjected to MALDI ToF/ToF mass spectrometry. Data were processed using a q-value based statistical approach to maximize protein quantification and identification. Technical (between duplicate samples) and biological variance (between and within individuals) were calculated and power analysis was thereby enabled. An a priori power analysis was carried out using samples from healthy volunteers to define sample sizes required for robust biomarker identification. The result was subsequently validated with a post hoc power analysis using a real clinical setting involving pancreatic cancer patients. This demonstrated that six samples per group (e.g., pre- vs post-treatment) may provide sufficient statistical power for most proteins with changes>2 fold. A reference standard allowed direct comparison of protein expression changes between multiple experiments. Analysis of patient plasma prior to treatment identified 29 proteins with significant changes within individual patient. Changes in Peroxiredoxin II levels were confirmed by Western blot. This q-value based statistical approach in combination with reference standard samples can be applied with confidence in the design and execution of clinical studies for predictive, prognostic, and/or pharmacodynamic biomarker discovery. The power analysis provides information required prior to study initiation.

  1. Dietary considerations in designing nutrition intervention programmes in rural areas of Kenya.

    Mwadime, R K; Muita, J W; Omwega, A M; Havemann, K


    A comparative study was carried out in three localities in Kenya: Kwale, Mbooni and Lwak in an attempt to identify dietary factors important in designing community based nutrition interventions. The data indicate geographical differences in age at weaning, reasons for termination of breastfeeding, the variety in the diets consumed and the nutrient intake adequacy. However, there was no difference in the duration in breastfeeding and, for children above 6 months (a period when weaning is recommended) rarely was there any food termed as "baby food" but children consumed bits and portions of the family food. In all the localities, there was no statistical difference between households with malnourished children and those without in most of the factors. Households with children admitted in the nutritional rehabilitation centres in the localities were, however, different in most of the characteristics examined. It is concluded that dietary interventions should be targeted to households and not children, mothers' care and nutrition are of paramount importance if the nutrition condition of their children is to be improved and, planning of nutritional interventions should be specific to the districts.

  2. Rational design of CPP-based drug delivery systems: considerations from pharmacokinetics.

    Mickan, Arite; Sarko, Dikran; Haberkorn, Uwe; Mier, Walter


    Therapeutics are restricted from cellular internalization due to the biological barrier formed by the cell membrane. Especially for therapeutics with high molecular weight, strategies are required to enable delivery to intracellular targets. Cell-penetrating peptides (CPPs) represent a powerful tool to mediate the entry of large cargos such as proteins, siRNA and nanoparticles. The high diversity of CPPs is the prerequisite to use this class of carriers for various applications. However, therapies based on CPPs are hampered by their unfavorable pharmacokinetics, mainly dominated by their rapid renal clearance and their lack of specificity. Rational design is required to overcome these disadvantages and thereby exploits the actual potential of CPPs. We summarize and highlight the current state of knowledge with special emphasis on pharmacokinetics. The unclear internalization pathways of CPPs remain one of the main obstacles and therefore have been in the focus of research. In this review, several promising strategies such as the combination with targeting sequences, activatable CPPs and adjustment of the molecular weight are described. In addition, new absorption pathways such as nasal, pulmonary or transdermal uptake expand the applicability of CPPs and may be a promising prospect for clinical application.

  3. Ethical Consideration on "Designer Babies"%"设计婴儿"的伦理思考

    周匡果; 王一鸣; 王向; 王荣林


    Recently, the development of modern medical reproductive technology has led to the birth of "designer babies".The new technology brings about blessings and potential threatens at the same time, which causes a series of ethical, legal disputes. Facing the opening Pandora's Box, human should deal with it rationally for the benefit of mankind. Human can take use of ethics, ethical and juristical principles to ensure proper direction of the technology.%飞速发展的现代医学生技技术促使了"设计婴儿"的诞生."设计婴儿"的问世,为罹患不治之症的儿童带来了福音,同时,它对人类传统的生育方式和观念的冲击也引发了一系列的伦理、社会争议.面对潘多拉魔盒,我们不应该因噎废食,而应该理性面对,寻找可行可信的指针来规范"设计婴儿"的发展,为人类造福.

  4. Design Considerations for Aural Vital Signs Using PZT Piezoelectric Ceramics Sensor Based on the Computerization Method

    Jerapong Tantrakoon


    Full Text Available The purpose was to illustrate how system developed for measurement of the aural vital signs such as patient’s heart and lung sounds in the hospital. For heart sounds measurement must operate the frequency response between 20 – 800 Hz, and lung sounds measurement must operate the frequency response between 160 – 4,000 Hz. The method was designed PZT piezoelectric ceramics for both frequency response in the same PZT sensor. It converts a signal from aural vital sign form to voltage signal. The signal is suitably amplified and re-filtered in band pass frequency band. It is converted to digital signal by an analog to digital conversion circuitry developed for the purpose. The results were that all signals can fed to personal computer through the sound card port. With the supporting software for drawing of graphic on the screen, the signal for a specific duration is accessed and stored in the computer’s memory in term of each patient’s data. In conclusion, the data of each patient call dot pcg (.pcg for drawing graph and dot wave (.wave for sound listening or automatic sending via electronic mail to the physician for later analysis of interpreting the sounds on the basis of their time domain and frequency domain representation to diagnose heart disorders.

  5. Design Optimization of a Mecanum Wheel to Reduce Vertical Vibrations by the Consideration of Equivalent Stiffness

    Jong-Jin Bae


    Full Text Available Mecanum wheels are capable of moving a vehicle to any direction instantaneously by the combination of independent wheel rotations. Because the mecanum wheel is composed of a hub and rollers, however, it has unavoidable drawbacks such as vertical and horizontal vibrations due to the sequential contacts between rollers and ground. In order to investigate the dynamic characteristics of a mecanum wheel, we made a prototype and performed experiments to measure the vertical vibrations. Interestingly, it was observed that the vertical accelerations were asymmetric with respect to the average value of signals; the vibration signals of upward and downward directions show quite different shape. This asymmetric phenomenon was confirmed through the dynamic simulations performed by RecurDyn. In addition, the peak-to-peak and RMS values of the displacements and accelerations were calculated to investigate the effects of the curvature of rollers on the vertical vibrations of the vehicle. Furthermore, we proposed a mecanum wheel having a spring to attenuate the vibrations. It was also noted that the significant reduction of the vertical accelerations was observed due to the absence of the spring. Finally, considering the equivalent stiffness of the mecanum wheel for several different fillet radii, we found the optimal geometric design which minimizes the vertical vibration of a mecanum wheel.

  6. Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations

    Turk, Dennis C.; O’Connor, Alec B.; Dworkin, Robert H.; Chaudhry, Amina; Katz, Nathaniel P.; Adams, Edgar H.; Brownstein, John S.; Comer, Sandra D.; Dart, Richard; Dasgupta, Nabarun; Denisco, Richard A.; Klein, Michael; Leiderman, Deborah B.; Lubran, Robert; Rappaport, Bob A.; Zacny, James P.; Ahdieh, Harry; Burke, Laurie B.; Cowan, Penney; Jacobs, Petra; Malamut, Richard; Markman, John; Michna, Edward; Palmer, Pamela; Peirce-Sandner, Sarah; Potter, Jennifer S.; Raja, Srinivasa N.; Rauschkolb, Christine; Roland, Carl L.; Webster, Lynn R.; Weiss, Roger D.; Wolf, Kerry


    Opioids are essential to the management of pain in many patients, but they also are associated with potential risks for abuse, overdose, and diversion. A number of efforts have been devoted to the development of abuse-deterrent formulations of opioids to reduce these risks. This article summarizes a consensus meeting that was organized to propose recommendations for the types of clinical studies that can be used to assess the abuse deterrence of different opioid formulations. Due to the many types of individuals who may be exposed to opioids, an opioid formulation will need to be studied in several populations using various study designs in order to determine its abuse-deterrent capabilities. It is recommended that the research conducted to evaluate abuse deterrence should include studies assessing: (1) abuse liability; (2) the likelihood that opioid abusers will find methods to circumvent the deterrent properties of the formulation; (3) measures of misuse and abuse in randomized clinical trials involving pain patients with both low risk and high risk of abuse; and (4) post-marketing epidemiological studies. PMID:22770841

  7. Design of primary ground support during roadway development using empirical databases

    Ry Stone⇑


    There have been many design practices utilised within the coal mining industry to arrive at the minimum densities of primary ground support required during roadway development. This paper demonstrates the practical use of empirical databases, and focuses on the main drivers for ground support as demonstrated in conceptual models. Golder Associates’ empirical databases used for ground support include a primary roof support database and a primary rib support database. Both are based on successful ground support designs installed in mines in Australia, the US, the UK, South Africa, New Zealand, and Europe. The term‘successful”refers to those designs that were used on a repeated basis for the purpose of roadway devel-opment. The primary roof support database indicates that the major factors influencing successful roof support designs are roof competency, expressed as the coal mine roof rating (CMRR), and in situ stress. In regard to the primary rib support database, it is evident from the current database that the primary factors affecting the capacity of rib support required for a successful design are roadway height and depth of cover. These databases have been used to help determine the minimum primary ground support designs required at many mine sites in Australasia, Europe, and the US. This paper will demonstrate the effectiveness and practicality of these databases at two selected mines in Australia and the US. In order to improve the primary rib support database, this paper will also propose a new rib deformation rating based on the addition of site specific coal strength data for the Australian mines. The proposed rat-ing attempts to capture the main variables that define the behaviour of a buckling column.

  8. Design considerations for a limited angle, dedicated breast, TOF PET scanner

    Surti, S; Karp, J S [Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 (United States)], E-mail:, E-mail:


    Development of partial ring, dedicated breast positron emission tomography (PET) scanners is an active area of research. Due to the limited angular coverage, generation of distortion and artifact-free, fully 3D tomographic images is not possible without rotation of the detectors. With time-of-flight (TOF) information, it is possible to achieve the 3D tomographic images with limited angular coverage and without detector rotation. We performed simulations for a breast scanner design with a ring diameter and an axial length of 15 cm and comprising a full (180{sup 0} in-plane angular coverage), 2/3 (120{sup 0} in-plane angular coverage) or 1/2 (90{sup 0} in-plane angular coverage) ring detector. Our results show that as the angular coverage decreases, improved timing resolution is needed to achieve distortion-free and artifact-free images with TOF. The contrast recovery coefficient (CRC) value for small hot lesions in a partial ring scanner is similar to a full ring non-TOF scanner. Our results indicate that a timing resolution of 600 ps is needed for a 2/3 ring scanner, while a timing resolution of 300 ps is needed for a 1/2 ring scanner. We also analyzed the ratio of lesion CRC to the background pixel noise (SNR) and concluded that TOF improves the SNR values of the partial ring scanner, and helps to compensate for the loss in sensitivity due to reduced geometric sensitivity in a limited angle coverage PET scanner. In particular, it is possible to maintain similar SNR characteristic in a 2/3 ring scanner with a timing resolution of 300 ps as in a full ring non-TOF scanner.

  9. Design considerations for a limited angle, dedicated breast, TOF PET scanner

    Surti, S.; Karp, J. S.


    Development of partial ring, dedicated breast positron emission tomography (PET) scanners is an active area of research. Due to the limited angular coverage, generation of distortion and artifact-free, fully 3D tomographic images is not possible without rotation of the detectors. With time-of-flight (TOF) information, it is possible to achieve the 3D tomographic images with limited angular coverage and without detector rotation. We performed simulations for a breast scanner design with a ring diameter and an axial length of 15 cm and comprising a full (180° in-plane angular coverage), 2/3 (120° in-plane angular coverage) or 1/2 (90° in-plane angular coverage) ring detector. Our results show that as the angular coverage decreases, improved timing resolution is needed to achieve distortion-free and artifact-free images with TOF. The contrast recovery coefficient (CRC) value for small hot lesions in a partial ring scanner is similar to a full ring non-TOF scanner. Our results indicate that a timing resolution of 600 ps is needed for a 2/3 ring scanner, while a timing resolution of 300 ps is needed for a 1/2 ring scanner. We also analyzed the ratio of lesion CRC to the background pixel noise (SNR) and concluded that TOF improves the SNR values of the partial ring scanner, and helps to compensate for the loss in sensitivity due to reduced geometric sensitivity in a limited angle coverage PET scanner. In particular, it is possible to maintain similar SNR characteristic in a 2/3 ring scanner with a timing resolution of 300 ps as in a full ring non-TOF scanner.

  10. Considerations on Circuit Design and Data Acquisition of a Portable Surface Plasmon Resonance Biosensing System.

    Chang, Keke; Chen, Ruipeng; Wang, Shun; Li, Jianwei; Hu, Xinran; Liang, Hao; Cao, Baiqiong; Sun, Xiaohui; Ma, Liuzheng; Zhu, Juanhua; Jiang, Min; Hu, Jiandong


    The aim of this study was to develop a circuit for an inexpensive portable biosensing system based on surface plasmon resonance spectroscopy. This portable biosensing system designed for field use is characterized by a special structure which consists of a microfluidic cell incorporating a right angle prism functionalized with a biomolecular identification membrane, a laser line generator and a data acquisition circuit board. The data structure, data memory capacity and a line charge-coupled device (CCD) array with a driving circuit for collecting the photoelectric signals are intensively focused on and the high performance analog-to-digital (A/D) converter is comprehensively evaluated. The interface circuit and the photoelectric signal amplifier circuit are first studied to obtain the weak signals from the line CCD array in this experiment. Quantitative measurements for validating the sensitivity of the biosensing system were implemented using ethanol solutions of various concentrations indicated by volume fractions of 5%, 8%, 15%, 20%, 25%, and 30%, respectively, without a biomembrane immobilized on the surface of the SPR sensor. The experiments demonstrated that it is possible to detect a change in the refractive index of an ethanol solution with a sensitivity of 4.99838 × 10(5) ΔRU/RI in terms of the changes in delta response unit with refractive index using this SPR biosensing system, whereby the theoretical limit of detection of 3.3537 × 10(-5) refractive index unit (RIU) and a high linearity at the correlation coefficient of 0.98065. The results obtained from a series of tests confirmed the practicality of this cost-effective portable SPR biosensing system.

  11. Changing cluster composition in cluster randomised controlled trials: design and analysis considerations.

    Corrigan, Neil; Bankart, Michael J G; Gray, Laura J; Smith, Karen L


    There are many methodological challenges in the conduct and analysis of cluster randomised controlled trials, but one that has received little attention is that of post-randomisation changes to cluster composition. To illustrate this, we focus on the issue of cluster merging, considering the impact on the design, analysis and interpretation of trial outcomes. We explored the effects of merging clusters on study power using standard methods of power calculation. We assessed the potential impacts on study findings of both homogeneous cluster merges (involving clusters randomised to the same arm of a trial) and heterogeneous merges (involving clusters randomised to different arms of a trial) by simulation. To determine the impact on bias and precision of treatment effect estimates, we applied standard methods of analysis to different populations under analysis. Cluster merging produced a systematic reduction in study power. This effect depended on the number of merges and was most pronounced when variability in cluster size was at its greatest. Simulations demonstrate that the impact on analysis was minimal when cluster merges were homogeneous, with impact on study power being balanced by a change in observed intracluster correlation coefficient (ICC). We found a decrease in study power when cluster merges were heterogeneous, and the estimate of treatment effect was attenuated. Examples of cluster merges found in previously published reports of cluster randomised trials were typically homogeneous rather than heterogeneous. Simulations demonstrated that trial findings in such cases would be unbiased. However, simulations also showed that any heterogeneous cluster merges would introduce bias that would be hard to quantify, as well as having negative impacts on the precision of estimates obtained. Further methodological development is warranted to better determine how to analyse such trials appropriately. Interim recommendations include avoidance of cluster merges where

  12. Considerations on Circuit Design and Data Acquisition of a Portable Surface Plasmon Resonance Biosensing System

    Keke Chang


    Full Text Available The aim of this study was to develop a circuit for an inexpensive portable biosensing system based on surface plasmon resonance spectroscopy. This portable biosensing system designed for field use is characterized by a special structure which consists of a microfluidic cell incorporating a right angle prism functionalized with a biomolecular identification membrane, a laser line generator and a data acquisition circuit board. The data structure, data memory capacity and a line charge-coupled device (CCD array with a driving circuit for collecting the photoelectric signals are intensively focused on and the high performance analog-to-digital (A/D converter is comprehensively evaluated. The interface circuit and the photoelectric signal amplifier circuit are first studied to obtain the weak signals from the line CCD array in this experiment. Quantitative measurements for validating the sensitivity of the biosensing system were implemented using ethanol solutions of various concentrations indicated by volume fractions of 5%, 8%, 15%, 20%, 25%, and 30%, respectively, without a biomembrane immobilized on the surface of the SPR sensor. The experiments demonstrated that it is possible to detect a change in the refractive index of an ethanol solution with a sensitivity of 4.99838 × 105 ΔRU/RI in terms of the changes in delta response unit with refractive index using this SPR biosensing system, whereby the theoretical limit of detection of 3.3537 × 10−5 refractive index unit (RIU and a high linearity at the correlation coefficient of 0.98065. The results obtained from a series of tests confirmed the practicality of this cost-effective portable SPR biosensing system.

  13. Design Considerations for Spacecraft Operations During Uncrewed Dormant Phases of Human Exploration Missions

    Williams-Byrd, Julie; Antol, Jeff; Jefferies, Sharon; Goodliff, Kandyce; Williams, Phillip; Ambrose, Rob; Sylvester, Andre; Anderson, Molly; Dinsmore, Craig; Hoffman, Stephen; Lawrence, James; Seibert, Marc; Schier, Jim; Frank, Jeremy; Alexander, Leslie; Ruff, Gary; Soeder, Jim; Guinn, Joseph; Stafford, Matthew


    NASA is transforming human spaceflight. The Agency is shifting from an exploration-based program with human activities in low Earth orbit (LEO) and targeted robotic missions in deep space to a more sustainable and integrated pioneering approach. However, pioneering space involves daunting technical challenges of transportation, maintaining health, and enabling crew productivity for long durations in remote, hostile, and alien environments. Subject matter experts from NASA's Human Exploration and Operations Mission Directorate (HEOMD) are currently studying a human exploration campaign that involves deployment of assets for planetary exploration. This study, called the Evolvable Mars Campaign (EMC) study, explores options with solar electric propulsion as a central component of the transportation architecture. This particular in-space transportation option often results in long duration transit to destinations. The EMC study is also investigating deployed human rated systems like landers, habitats, rovers, power systems and ISRU system to the surface of Mars, which also will involve long dormant periods when these systems are staged on the surface. In order to enable the EMC architecture, campaign and element design leads along with system and capability development experts from HEOMD's System Maturation Team (SMT) have identified additional capabilities, systems and operation modes that will sustain these systems especially during these dormant phases of the mission. Dormancy is defined by the absence of crew and relative inactivity of the systems. For EMC missions, dormant periods could range from several months to several years. Two aspects of uncrewed dormant operations are considered herein: (1) the vehicle systems that are placed in a dormant state and (2) the autonomous vehicle systems and robotic capabilities that monitor, maintain, and repair the vehicle and systems. This paper describes the mission stages of dormancy operations, phases of dormant

  14. Migration of persons between households in rural Alaska: considerations for study design

    Dana Bruden


    11% of individuals change households. These are important demographic figures to consider when planning and designing studies that measure an epidemiological exposure at the household level. Power and sample size calculations should account for the loss to follow-up associated with in- and out-migration of individuals from households.

  15. Nuclear safety considerations in the conceptual design of a fast reactor for space electric power and propulsion

    Hsieh, T.-M.; Koenig, D. R.


    Some nuclear safety aspects of a 3.2 mWt heat pipe cooled fast reactor with out-of-core thermionic converters are discussed. Safety related characteristics of the design including a thin layer of B4C surrounding the core, the use of heat pipes and BeO reflector assembly, the elimination of fuel element bowing, etc., are highlighted. Potential supercriticality hazards and countermeasures are considered. Impacts of some safety guidelines of space transportation system are also briefly discussed, since the currently developing space shuttle would be used as the primary launch vehicle for the nuclear electric propulsion spacecraft.

  16. Simulation-guided phase 3 trial design to evaluate vaccine effectiveness to prevent Ebola virus disease infection: Statistical considerations, design rationale, and challenges.

    Vandebosch, An; Mogg, Robin; Goeyvaerts, Nele; Truyers, Carla; Greenwood, Brian; Watson-Jones, Debby; Herrera-Taracena, Guillermo; Parys, Wim; Vangeneugden, Tony


    Starting in December 2013, West Africa was overwhelmed with the deadliest outbreak of Ebola virus known to date, resulting in more than 27,500 cases and 11,000 deaths. In response to the epidemic, development of a heterologous prime-boost vaccine regimen was accelerated and involved preparation of a phase 3 effectiveness study. While individually randomized controlled trials are widely acknowledged as the gold standard for demonstrating the efficacy of a candidate vaccine, there was considerable debate on the ethical appropriateness of these designs in the context of an epidemic. A suitable phase 3 trial must convincingly ensure unbiased evaluation with sufficient statistical power. In addition, efficient evaluation of a vaccine candidate is required so that an effective vaccine can be immediately disseminated. This manuscript aims to present the statistical and modeling considerations, design rationale and challenges encountered due to the emergent, epidemic setting that led to the selection of a cluster-randomized phase 3 study design under field conditions.

  17. An Intervention Framework Designed to Develop the Collaborative Problem-Solving Skills of Primary School Students

    Gu, Xiaoqing; Chen, Shan; Zhu, Wenbo; Lin, Lin


    Considerable effort has been invested in innovative learning practices such as collaborative inquiry. Collaborative problem solving is becoming popular in school settings, but there is limited knowledge on how to develop skills crucial in collaborative problem solving in students. Based on the intervention design in social interaction of…

  18. An Intervention Framework Designed to Develop the Collaborative Problem-Solving Skills of Primary School Students

    Gu, Xiaoqing; Chen, Shan; Zhu, Wenbo; Lin, Lin


    Considerable effort has been invested in innovative learning practices such as collaborative inquiry. Collaborative problem solving is becoming popular in school settings, but there is limited knowledge on how to develop skills crucial in collaborative problem solving in students. Based on the intervention design in social interaction of…

  19. A low-power 10 bit ADC in a 025 mum CMOS Design considerations and test results

    Rivetti, A; Anghinolfi, F; Mazza, G; Rotondo, F


    This paper presents the design and test of a low power analog to digital converter implemented in a commercial 0.25 mum CMOS technology. The circuit has been developed to serve as a building block in multi-channel data acquisition systems for High Energy Physics (HEP) applications. Therefore medium resolution (10 bits), very low power consumption and high modularity are the key features of the design. In HEP experiments the resistance of the electronics to the ionizing radiation is often a primary issue. Hence the ADC has been laid-out using a radiation tolerant approach. The test results show that the chip operates as a full 10 bit converter up to a clock frequency of 30 MHz. No degradation in performance has been measured after a total dose of 1Q Mrd (SiO//2). 7 Refs.

  20. Beyond Informed Consent: Ethical Considerations in the Design and Implementation of Sexual and Reproductive Health Research Among Adolescents

    Folayan, Morenike Oluwatoyin; Haire, Bridget; Harrison, Abigail; Fatusi, Olawunmi; Brown, Brandon


    Interest in addressing the ethical issues related to adolescents’ engagement in research, especially sexual and reproductive health and rights (SRHR) research is increasing in view of the need to design and implement research that address peculiar SRHR needs of adolescents. These needs include issues of sexually transmitted infections, HIV, AIDS, adverse pregnancy outcomes, community, family and relationship violence and mental health. Unfortunately, adolescents’ voluntary participation in research has been limited due to their perceived potential to be coerced into participation, and concerns that they may not fully comprehend the issues related to research risks. As such, many of the regulations for engaging research participants have been defined by age rather than due consideration of psychological development. This paper examines the various potential ethical issues that may impact on decision making when adolescents are engaged in research. These include the need to minimise therapeutic misconception, considerations for recruitment and retention, types and amounts for reimbursement, and engagement of communities of adolescents on advisory boards of studies that involve their population. The potential challenges associated with recruitment of adolescents in early child marriages were also highlighted. PMID:26050384

  1. Modeling and design considerations of a photovoltaic energy source feeding a synchronous reluctance motor suitable for pumping systems

    M. Nabil


    Full Text Available This paper presents the performance analysis of a photovoltaic (PV energy source driving a synchronous reluctance (SyncRel motor. The design considerations of the PV array, suitable for driving a centrifugal pump, are studied. Three design approaches are proposed at an average insolation of 0.5 kW/m2. These approaches depend upon determining the system operating point firstly and then maintaining this point on the PV generator characteristics. The first approach takes motor starting current into account as an additional design criterion. The second one is based on achieving the maximum power at the system operating point. The third approach considers maintaining voltage regulation of the PV generator at a pre-specified suitable value. A sample of the simulation results is introduced using the SyncRel motor measured parameters and the estimated parameters of the PV array. It has been found that the minimum number of cells can be achieved using the second approach.

  2. HIV treatment as prevention: considerations in the design, conduct, and analysis of cluster randomized controlled trials of combination HIV prevention.

    Marie-Claude Boily

    Full Text Available The rigorous evaluation of the impact of combination HIV prevention packages at the population level will be critical for the future of HIV prevention. In this review, we discuss important considerations for the design and interpretation of cluster randomized controlled trials (C-RCTs of combination prevention interventions. We focus on three large C-RCTs that will start soon and are designed to test the hypothesis that combination prevention packages, including expanded access to antiretroviral therapy, can substantially reduce HIV incidence. Using a general framework to integrate mathematical modelling analysis into the design, conduct, and analysis of C-RCTs will complement traditional statistical analyses and strengthen the evaluation of the interventions. Importantly, even with combination interventions, it may be challenging to substantially reduce HIV incidence over the 2- to 3-y duration of a C-RCT, unless interventions are scaled up rapidly and key populations are reached. Thus, we propose the innovative use of mathematical modelling to conduct interim analyses, when interim HIV incidence data are not available, to allow the ongoing trials to be modified or adapted to reduce the likelihood of inconclusive outcomes. The preplanned, interactive use of mathematical models during C-RCTs will also provide a valuable opportunity to validate and refine model projections.

  3. Advanced design and economic considerations for commercial geothermal power plants at Heber and Niland, California. Final report


    Two separate studies, involving advanced design and economic considerations for commercial geothermal power plants using liquid-dominated hydrothermal resources, are presented. In the first study, the effects on design, capital cost, and bus bar electric energy production cost caused by an anticipated decline in available geothermal fluid temperature over the lifetime of power plants are described. A two-stage, flashed-steam energy conversion process was used for the conceptual design of the power plants, which operate from the moderate-temperature, low-salinity reservoir at Heber, California. Plants with net capacities of 50, 100, and 200 MWe (net) were investigated. The results show that it is important to include provision for geothermal fluid temperature decline in the design of power plants to prevent loss of electric energy production capability and to reduce bus bar electric energy costs. In the second study, the technical, economic, and environmental effects of adding regeneration to a 50 MWe (net) power plant employing the multistage-flash/binary process are described. Regeneration is potentially attractive because it recovers waste heat from the turbine exhaust and uses it in the power cycle. However, the pressure drop caused by the introduction of the regenerator decreases the turbine expansion and thus decreases system performance. An innovative approach was taken in the design of the regenerator, which minimized the expected performance degradation of the turbine. The result was that the performance, capital cost, and bus bar electric energy production cost are nearly the same for the processes with and without regeneration. On the other hand, the addition of regeneration has the environmental benefits of substantially reducing heat rejection to the atmosphere and cooling tower makeup and blowdown water requirements. It also increases the temperature of the brine returned to the field for reinjection.

  4. Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry.

    Hruby, V J; Shenderovich, M; Lam, K S; Lebl, M


    A critical issue in drug discovery utilizing combinatorial chemistry as part of the discovery process is the choice of scaffolds to be used for a proper presentation, in a three-dimensional space, of the critical elements of structure necessary for molecular recognition (binding) and information transfer (agonist/ antagonist). In the case of polypeptide ligands, considerations related to the properties of various backbone structures (alpha-helix, beta-sheets, etc.; phi, psi space) and those related to three-dimensional presentation of side-chain moieties (topography; chi (chi) space) must be addressed, although they often present quite different elements in the molecular recognition puzzle. We have addressed aspects of this problem by examining the three-dimensional structures of chemically different scaffolds at various distances from the scaffold to evaluate their putative diversity. We find that chemically diverse scaffolds can readily become topographically similar. We suggest a topographical approach involving design in chi space to deal with these problems.

  5. Design Considerations and Research Needs for Expanding the Current Perceptual Model of Spatial Orientation into an In-Cockpit Spatial Disorientation Warning System


    USAARL Report No. 2017-07 Design Considerations and Research Needs for Expanding the Current Perceptual Model of Spatial Orientation into an In...19b. TELEPHONE NUMBER (Include area code) 30-11-2016 Final Design Considerations and Research Needs for Expanding the Current Perceptual Model of... International Journal of Human-Computer Studies, 58, 697-718. Kelley, A. M., Grandizio, C. M., Estrada, A., & Crowley, J. C. (2014). Tactile cues

  6. Collaborative Robotics Design Considerations


    in Multirobot Systems," IEEE Transactions on Robotics and Automation, Vol. 18, No. 5, October 2002 [3] Batavia, P., "A Survey of Collaborative... Transactions on Robotics and Automation, Vol. 18, No.5, Oct. 2002, pp 781-795. [21]Scholtz, J.C., "Human-Robot Interactions: Creating Synergistic Cyber...Parker, L.E, eds., Kluwer Academic Publishers, 2002, pp 185-193. [20] Roumeliotis, S., Bekey, G.A., "Distributed Multirobot Localization," IEEE

  7. Design study of primary ion provider for relativistic heavy ion collider electron beam ion source.

    Kondo, K; Kanesue, T; Tamura, J; Okamura, M


    Brookhaven National Laboratory has developed the new preinjector system, electron beam ion source (EBIS) for relativistic heavy ion collider (RHIC) and National Aeronautics and Space Administration Space Radiation Laboratory. Design of primary ion provider is an essential problem since it is required to supply beams with different ion species to multiple users simultaneously. The laser ion source with a defocused laser can provide a low charge state and low emittance ion beam, and is a candidate for the primary ion source for RHIC-EBIS. We show a suitable design with appropriate drift length and solenoid, which helps to keep sufficient total charge number with longer pulse length. The whole design of primary ion source, as well as optics arrangement, solid targets configuration and heating about target, is presented.

  8. Design considerations and experimental observations for the TAMU air-cooled reactor cavity cooling system for the VHTR

    Sulaiman, S. A.; Dominguez-Ontiveros, E. E.; Alhashimi, T.; Budd, J. L.; Matos, M. D.; Hassan, Y. A.


    The Reactor Cavity Cooling System (RCCS) is a promising passive decay heat removal system for the Very High Temperature Reactor (VHTR) to ensure reliability of the transfer of the core residual and decay heat to the environment under all off-normal circumstances. A small scale experimental test facility was constructed at Texas A&M University (TAMU) to study pertinent multifaceted thermal hydraulic phenomena in the air-cooled reactor cavity cooling system (RCCS) design based on the General Atomics (GA) concept for the Modular High Temperature Gas-Cooled Reactor (MHTGR). The TAMU Air-Cooled Experimental Test Facility is ⅛ scale from the proposed GA-MHTGR design. Groundwork for experimental investigations focusing into the complex turbulence mixing flow behavior inside the upper plenum is currently underway. The following paper illustrates some of the chief design considerations used in construction of the experimental test facility, complete with an outline of the planned instrumentation and data acquisition methods. Computational Fluid Dynamics (CFD) simulations were carried out to furnish some insights on the overall behavior of the air flow in the system. CFD simulations assisted the placement of the flow measurement sensors location. Preliminary experimental observations of experiments at 120oC inlet temperature suggested the presence of flow reversal for cases involving single active riser at both 5 m/s and 2.25 m/s, respectively and four active risers at 2.25 m/s. Flow reversal may lead to thermal stratification inside the upper plenum by means of steady state temperature measurements. A Particle Image Velocimetry (PIV) experiment was carried out to furnish some insight on flow patterns and directions.

  9. Design considerations and experimental observations for the TAMU air-cooled reactor cavity cooling system for the VHTR

    Sulaiman, S. A., E-mail:; Dominguez-Ontiveros, E. E., E-mail:; Alhashimi, T., E-mail:; Budd, J. L., E-mail:; Matos, M. D., E-mail:; Hassan, Y. A., E-mail: [Department of Nuclear Engineering, Texas A and M University, College Station, TX, 77843-3133 (United States)


    The Reactor Cavity Cooling System (RCCS) is a promising passive decay heat removal system for the Very High Temperature Reactor (VHTR) to ensure reliability of the transfer of the core residual and decay heat to the environment under all off-normal circumstances. A small scale experimental test facility was constructed at Texas A and M University (TAMU) to study pertinent multifaceted thermal hydraulic phenomena in the air-cooled reactor cavity cooling system (RCCS) design based on the General Atomics (GA) concept for the Modular High Temperature Gas-Cooled Reactor (MHTGR). The TAMU Air-Cooled Experimental Test Facility is ⅛ scale from the proposed GA-MHTGR design. Groundwork for experimental investigations focusing into the complex turbulence mixing flow behavior inside the upper plenum is currently underway. The following paper illustrates some of the chief design considerations used in construction of the experimental test facility, complete with an outline of the planned instrumentation and data acquisition methods. Computational Fluid Dynamics (CFD) simulations were carried out to furnish some insights on the overall behavior of the air flow in the system. CFD simulations assisted the placement of the flow measurement sensors location. Preliminary experimental observations of experiments at 120oC inlet temperature suggested the presence of flow reversal for cases involving single active riser at both 5 m/s and 2.25 m/s, respectively and four active risers at 2.25 m/s. Flow reversal may lead to thermal stratification inside the upper plenum by means of steady state temperature measurements. A Particle Image Velocimetry (PIV) experiment was carried out to furnish some insight on flow patterns and directions.

  10. Designing Tasks to Promote and Assess Mathematical Transfer in Primary School Children

    Clark, Julie; Page, Shaileigh; Thornton, Steve


    This study aims to design learning situations and tasks that promote and assess the capacity of primary school children to transfer mathematical knowledge to new contexts. We discuss previous studies investigating mathematical transfer, and particularly the strengths and limitations of tasks used to assess transfer in these studies. We describe…

  11. Reliability and Validity of the Rey Visual Design Learning Test in Primary School Children

    Wilhelm, P.


    The Rey Visual Design Learning Test (Rey, 1964, in Spreen & Strauss, 1991) assesses immediate memory span, new learning and recognition for non-verbal material. Three studies are presented that focused on the reliability and validity of the RVDLT in primary school children. Test-retest reliability a

  12. Health effects of freshwater bathing among primary school children; Design for a randomised exposure study

    Asperen IA van; Medema GJ; Havelaar AH; Borgdorff MW; CIE; MGB


    To study the health effects of bathing in freshwaters that meet current water quality standard, large epidemiological studies are needed. A design is presented of a study among primary school children, that aims to evaluate current water quality standard. The study concerns a randomised exposure

  13. Design of an Optimally Integrated Primary Land Arctic Navigation System. (Plas). Volume 1. System Design,


    filtre de Kalman huit tats de capacitd accrue, conu pour traiter les mesures des capteurs, fournit une estimation optimale de la position, de la augment the gyro and provide a rough initial heading. An eight state extended Kalman Filter was designed to process the measurements from these...COMPUTER ............................................ *........... 38 5.0 DISPLAYS ............................................... oo... ... 40 6.0 KALMAN

  14. Preliminary Considerations on the Thermodynamic Feasibility and Possible Design of Ultra-, Micro- and Nano-Gas Turbines

    Enrico Sciubba


    Full Text Available The paper describes a preliminary feasibility analysis of a nano-GT (50÷200 W for portable power generation. The system is examined under both a thermodynamic and an operative point of view. The technical problems posed by a practical implementation of an operative system are assessed first via a preliminary calculation of the overall thermodynamic performance of the real cycle, and then via a first-order design of the main components. The extremely small size of the device makes a preliminary estimate of the components performance problematic (the available data are scant and unreliable: it is likely that a real advance in this field must go through a series of detailed fluid-dynamic simulations. The results of our preliminary sizing are compared with the existing technical literature in an attempt to further define the material selection, in view of a possible prototype production. Some considerations are also offered about the final utilisation of nano-GTs: in our opinion, they represent a realistic alternative to batteries for powering optical, GPS and other satellite devices, or in medical applications.

  15. Designing a valid randomized pragmatic primary care implementation trial: the my own health report (MOHR) project.

    Krist, Alex H; Glenn, Beth A; Glasgow, Russell E; Balasubramanian, Bijal A; Chambers, David A; Fernandez, Maria E; Heurtin-Roberts, Suzanne; Kessler, Rodger; Ory, Marcia G; Phillips, Siobhan M; Ritzwoller, Debra P; Roby, Dylan H; Rodriguez, Hector P; Sabo, Roy T; Sheinfeld Gorin, Sherri N; Stange, Kurt C


    There is a pressing need for greater attention to patient-centered health behavior and psychosocial issues in primary care, and for practical tools, study designs and results of clinical and policy relevance. Our goal is to design a scientifically rigorous and valid pragmatic trial to test whether primary care practices can systematically implement the collection of patient-reported information and provide patients needed advice, goal setting, and counseling in response. This manuscript reports on the iterative design of the My Own Health Report (MOHR) study, a cluster randomized delayed intervention trial. Nine pairs of diverse primary care practices will be randomized to early or delayed intervention four months later. The intervention consists of fielding the MOHR assessment--addresses 10 domains of health behaviors and psychosocial issues--and subsequent provision of needed counseling and support for patients presenting for wellness or chronic care. As a pragmatic participatory trial, stakeholder groups including practice partners and patients have been engaged throughout the study design to account for local resources and characteristics. Participatory tasks include identifying MOHR assessment content, refining the study design, providing input on outcomes measures, and designing the implementation workflow. Study outcomes include the intervention reach (percent of patients offered and completing the MOHR assessment), effectiveness (patients reporting being asked about topics, setting change goals, and receiving assistance in early versus delayed intervention practices), contextual factors influencing outcomes, and intervention costs. The MOHR study shows how a participatory design can be used to promote the consistent collection and use of patient-reported health behavior and psychosocial assessments in a broad range of primary care settings. While pragmatic in nature, the study design will allow valid comparisons to answer the posed research question, and

  16. Design Considerations for a UCAV Wing for Subsonic and Transonic Aeroelastic and Flight Mechanic Wind Tunnel Tests


    actuation device in the wing will increase the model complexity considerably and very probably stiffen the wing considerably. Figure 6: Desing ...7] [8] research /groups/ucav/ [9] Kudva, J.N.: Overview of the DARPA Smart Wing

  17. Design and Coupled Thermo-Mechanical Analysis of Silicon Carbide Primary Mirror Assembly

    HAN Yuan-yuan; ZHANG Yu-min; HAN Jie-cai


    Based on the principle that the thermal expansion coefficient of the support structure should match that of the mirror, three schemes of primary mirror assembly were designed. Of them, the first is fused silica mirror plus 4J32 flexible support plus ZTC4 support back plate, the second K9 mirror plus 4J45 flexible support plus ZTC4 support back plate, and the third SiC mirror plus SiC rigid support back plate. A coupled thermo-mechanical analysis of the three primary mirror assemblies was made with finite element method. The results show that the SiC assembly is the best of all schemes in terms of their combination properties due to its elimination of the thermal expansion mismatch between the materials. The analytical results on the cryogenic property of the SiC primary mirror assembly show a higher surface finish of the SiC mirror even under the cryogenic condition.

  18. Designing Excellence and Quality Model for Training Centers of Primary Health Care: A Delphi Method Study

    Jafar-Sadegh TABRIZI


    Full Text Available Background: Excellence and quality models are comprehensive methods for improving the quality of healthcare. The aim of this study was to design excellence and quality model for training centers of primary health care using Delphi method. Methods: In this study, Delphi method was used. First, comprehensive information were collected using literature review. In extracted references, 39 models were identified from 34 countries and related sub-criteria and standards were extracted from 34 models (from primary 39 models. Then primary pattern including 8 criteria, 55 sub-criteria, and 236 standards was developed as a Delphi questionnaire and evaluated in four stages by 9 specialists of health care system in Tabriz and 50 specialists from all around the country.Results: Designed primary model (8 criteria, 55 sub-criteria, and 236 standards were concluded with 8 criteria, 45 sub-criteria, and 192 standards after 4 stages of evaluations by specialists. Major criteria of the model are leadership, strategic and operational planning, resource management, information analysis, human resources management, process management, costumer results, and functional results, where the top score was assigned as 1000 by specialists. Functional results had the maximum score of 195 whereas planning had the minimum score of 60. Furthermore the most and the least sub-criteria was for leadership with 10 sub-criteria and strategic planning with 3 sub-criteria, respectively. Conclusion: The model that introduced in this research has been designed following 34 reference models of the world. This model could provide a proper frame for managers of health system in improving quality. Keywords: Quality model, Excellence model, Training centers, Primary cares, Iran

  19. Newly Designed Polypropylene Polyol with Terminated Primary Hydroxy Group and Application for Polyurethane Foam

    K.Maeda; M.Kaku; Y.Sakural; K.Nishiyama; H.Nakaminami


    1 Results Polypropylene polyol is very important chemical materials for polyurethane. We developed newly designed polypropylene polyol with terminated primary hydroxyl group. We focus on our new polypropylene polyol, and show its useful application for polyurethane foam. Polymerization of propyleneoxide is conventionally carried out in anionic polymerization process. In anionic process α-cleavage of propyleneoxide occurs rather than β-cleavage. Then the terminal hydroxyl group of the resulting polypropy...

  20. Designing display primaries with currently available light sources for UHDTV wide-gamut system colorimetry.

    Masaoka, Kenichiro; Nishida, Yukihiro; Sugawara, Masayuki


    The wide-gamut system colorimetry has been standardized for ultra-high definition television (UHDTV). The chromaticities of the primaries are designed to lie on the spectral locus to cover major standard system colorimetries and real object colors. Although monochromatic light sources are required for a display to perfectly fulfill the system colorimetry, highly saturated emission colors using recent quantum dot technology may effectively achieve the wide gamut. This paper presents simulation results on the chromaticities of highly saturated non-monochromatic light sources and gamut coverage of real object colors to be considered in designing wide-gamut displays with color filters for the UHDTV.


    Cojanu Florin


    Full Text Available In actual didactic design is need to anticipate problems that may arise during implementation of proposed interdisciplinary content in the physical education lesson in class, by projecting sequential forward type of content, there by ensuring quality and efficiency. Its necessary to include in the design content of physical education lessons in primary sequence type of feed-forward, to increase the quality and effectiveness of physical education lessons at the operational objectives achieved. To development modern didactics of physical education we can keep some purchases of traditionalteaching, but still with emphasis currently reconsidering its entire system on the content, forms, methods of education.

  2. The integration of occupational therapy into primary care: a multiple case study design


    Background For over two decades occupational therapists have been encouraged to enhance their roles within primary care and focus on health promotion and prevention activities. While there is a clear fit between occupational therapy and primary care, there have been few practice examples, despite a growing body of evidence to support the role. In 2010, the province of Ontario, Canada provided funding to include occupational therapists as members of Family Health Teams, an interprofessional model of primary care. The integration of occupational therapists into this model of primary care is one of the first large scale initiatives of its kind in North America. The objective of the study was to examine how occupational therapy services are being integrated into primary care teams and understand the structures supporting the integration. Methods A multiple case study design was used to provide an in-depth description of the integration of occupational therapy. Four Family Health Teams with occupational therapists as part of the team were identified. Data collection included in-depth interviews, document analyses, and questionnaires. Results Each Family Health Team had a unique organizational structure that contributed to the integration of occupational therapy. Communication, trust and understanding of occupational therapy were key elements in the integration of occupational therapy into Family Health Teams, and were supported by a number of strategies including co-location, electronic medical records and team meetings. An understanding of occupational therapy was critical for integration into the team and physicians were less likely to understand the occupational therapy role than other health providers. Conclusion With an increased emphasis on interprofessional primary care, new professions will be integrated into primary healthcare teams. The study found that explicit strategies and structures are required to facilitate the integration of a new professional group

  3. Clinical trial design in chronic obstructive pulmonary disease: current perspectives and considerations with regard to blinding of tiotropium

    Beeh Kai-Michael


    Full Text Available Abstract Randomised, double-blind, controlled trials are considered the gold standard for evaluating a pharmacological agent, as they minimise any potential bias. However, it is not always possible to perform double-blind trials, particularly for medications delivered via specific devices, e.g. inhalers. In such cases, open-label studies can be employed instead. Methods used to minimise any potential bias introduced by open-label study design include randomisation, crossover study design, and objective measurements of primary efficacy and safety variables. Concise reviews analysing the effect of blinding procedures of comparator drugs on outcomes in respiratory trials are limited. Here, we compare data from different chronic obstructive pulmonary disease trials with once-daily indacaterol versus a blinded or non-blinded comparator. The clinical trial programme for indacaterol, a once-daily, long-acting β2-agonist, used tiotropium as a comparator either in an open-label or blinded fashion. Data from these studies showed that the effects of tiotropium were consistent for forced expiratory volume in 1 second, an objective measure, across blinded and non-blinded studies. The data were consistent with previous studies of double-blind tiotropium, suggesting that the open-label use of tiotropium did not introduce treatment bias. The effect of tiotropium on subjective measures (St George’s Respiratory Questionnaire; transition dyspnoea index varied slightly across blinded and non-blinded studies, indicating that minimal bias was introduced by using open-label tiotropium. Importantly, the studies used randomised, open-label tiotropium patients to treatment allocation, a method shown to minimise bias to a greater degree than blinding. In conclusion, it is important when reporting a clinical trial to be transparent about who was blinded and how the blinding was performed; if the design is open-label, additional efforts must be made to minimise risk of

  4. An Ethnographically Informed Participatory Design of Primary Healthcare Information Technology in a Developing Country Setting.

    Shidende, Nima Herman; Igira, Faraja Teddy; Mörtberg, Christina Margaret


    Ethnography, with its emphasis on understanding activities where they occur, and its use of qualitative data gathering techniques rich in description, has a long tradition in Participatory Design (PD). Yet there are limited methodological insights in its application in developing countries. This paper proposes an ethnographically informed PD approach, which can be applied when designing Primary Healthcare Information Technology (PHIT). We use findings from a larger multidisciplinary project, Health Information Systems Project (HISP) to elaborate how ethnography can be used to facilitate participation of health practitioners in developing countries settings as well as indicating the importance of ethnographic approach to participatory Health Information Technology (HIT) designers. Furthermore, the paper discusses the pros and cons of using an ethnographic approach in designing HIT.

  5. Cluster randomized trials utilizing primary care electronic health records: methodological issues in design, conduct, and analysis (eCRT Study).

    Gulliford, Martin C; van Staa, Tjeerd P; McDermott, Lisa; McCann, Gerard; Charlton, Judith; Dregan, Alex


    There is growing interest in conducting clinical and cluster randomized trials through electronic health records. This paper reports on the methodological issues identified during the implementation of two cluster randomized trials using the electronic health records of the Clinical Practice Research Datalink (CPRD). Two trials were completed in primary care: one aimed to reduce inappropriate antibiotic prescribing for acute respiratory infection; the other aimed to increase physician adherence with secondary prevention interventions after first stroke. The paper draws on documentary records and trial datasets to report on the methodological experience with respect to research ethics and research governance approval, general practice recruitment and allocation, sample size calculation and power, intervention implementation, and trial analysis. We obtained research governance approvals from more than 150 primary care organizations in England, Wales, and Scotland. There were 104 CPRD general practices recruited to the antibiotic trial and 106 to the stroke trial, with the target number of practices being recruited within six months. Interventions were installed into practice information systems remotely over the internet. The mean number of participants per practice was 5,588 in the antibiotic trial and 110 in the stroke trial, with the coefficient of variation of practice sizes being 0.53 and 0.56 respectively. Outcome measures showed substantial correlations between the 12 months before, and after intervention, with coefficients ranging from 0.42 for diastolic blood pressure to 0.91 for proportion of consultations with antibiotics prescribed, defining practice and participant eligibility for analysis requires careful consideration. Cluster randomized trials may be performed efficiently in large samples from UK general practices using the electronic health records of a primary care database. The geographical dispersal of trial sites presents a difficulty for

  6. Effect of implant macro-design on primary stability: A prospective clinical study

    Lozano-Carrascal, Naroa; Salomó-Coll, Oscar; Gilabert-Cerdà, Marta; Farré-Pagés, Nuria; Hernández-Alfaro, Federico


    Background Implant restorations have become a high predictable treatment option. Several caracteristics such as surgical technique and implant design can influence the treatment outcomes. The aim of the present study was to evaluate the influence of implant macro-design on primary stability measured with resonance frequency analysis (RFA) and insertion torque (IT). Material and Methods A total of 47 implants divided in two groups: Test group (TI): 22 Tapered MIS® Seven implants; Control group (CI): 25 cylindrical Astra® Osseospeed implants. All implants were inserted following the manufacturers’ standard protocols. Implant primary stability was measured at the moment of implant placement by registering insertion torque values (ITv) and ISQ values by means of Osstell™ Mentor (ISQv) (Integration Diagnostic Ltd., Goteborg, Sweden). Results In the mandible, mean ISQv for tapered implants (TI) was 71.67±5.16 and for cylindrical implants (CI) 57.15±4.83 (p=0.01). Mean insertion torque was 46.67±6.85 Ncm for TI and 35.77±6.72 Ncm for CI (p=0.01). In the maxilla, mean ISQ was 67.2±4.42 for tapered implants and 49.17±15.30 for cylindrical implants (p=0.01). Mean insertion torque for TI was 41.5±6.26 Ncm and for CI 39.17±6.34 Ncm (p>0.05). For tapered implants, no correlation could be found between implant diameter and primary stability. But for cylindrical implants there was a statistically significant correlation between implant diameter and primary stability: ITv (p=0.03); ISQv (p=0.04). Conclusions Within the limits of the present study, tapered shaped implants achieve higher primary stability measured through ISQ and insertion torque values. Moreover, for cylindrical implants positive correlation has been established between implant diameter and primary stability. Key words:Primary stability, tapered, cylindrical, conical, implant macro-design. PMID:26827067

  7. Thermal analysis and cooling structure design of the primary collimator in CSNS/RCS

    Zou, Yi-Qing; Kang, Ling; Qu, Hua-Min; He, Zhe-Xi; Yu, Jie-Bing; 10.1088/1674-1137/37/5/057004


    The rapid cycling synchrotron (RCS) of the China Spallation Neutron Source (CSNS) is a high intensity proton ring with beam power of 100 kW. In order to control the residual activation to meet the requirements of hands-on maintenance, a two-stage collimation system has been designed for the RCS. The collimation system consists of one primary collimator made of thin metal to scatter the beam and four secondary collimators as absorbers. Thermal analysis is an important aspect in evaluating the reliability of the collimation system. The calculation of the temperature distribution and thermal stress of the primary collimator with different materials is carried out by using ANSYS code. In order to control the temperature rise and thermal stress of the primary collimator to a reasonable level, an air cooling structure is intended to be used. The mechanical design of the cooling structure is presented, and the cooling effciency with different chin numbers and wind velocity is also analyzed. Finally, the fatigue life...

  8. Using students' misconceptions of primary coloured lights to design a hands-on coloured light mixer

    Nopparatjamjomras, Suchai; Chitaree, Ratchapak


    A surface mount typed multi-coloured Light-Emitting Diode (LED) is used as a light source for the hands-on coloured light mixer. The LED consists of red, green and blue tiny sources but the mixer is designed to have four switches corresponding to red, green, blue and yellow light. These colours correspond to students' misconceptions of primary coloured lights; they realize that the primary colours and the rules for lights mixing are the same as those of paints. To generate a yellow light, a microcontroller placed between four input switches and the LED operates both a red and green tiny sources. In addition, the microcontroller is employed to eliminate some combinations of coloured light mixing to simplify the experiment (basic mode) for non advanced students. If the mixer is used with more advanced students, a number of combinations will increase and students need more analytical skills to find out the primary coloured lights (the coloured lights that can not be produced by the mixing of any other coloured lights). Therefore, the mixer is able to use with more advanced and non advanced students depending on the program in the microcontroller and some modifications of the circuit. Furthermore, to introduce students an idea that other hues or shades can be generated by mixing of these three primary coloured lights of different intensities, a tuning circuit is integrated to vary an intensity of the green light source.

  9. Design and Stability of Load-Side Primary Frequency Control in Power Systems

    Zhao, CH; Topcu, U; Li, N; Low, S


    We present a systematic method to design ubiquitous continuous fast-acting distributed load control for primary frequency regulation in power networks, by formulating an optimal load control (OLC) problem where the objective is to minimize the aggregate cost of tracking an operating point subject to power balance over the network. We prove that the swing dynamics and the branch power flows, coupled with frequency-based load control, serve as a distributed primal-dual algorithm to solve OLC. We establish the global asymptotic stability of a multimachine network under such type of load-side primary frequency control. These results imply that the local frequency deviations on each bus convey exactly the right information about the global power imbalance for the loads to make individual decisions that turn out to be globally optimal. Simulations confirm that the proposed algorithm can rebalance power and resynchronize bus frequencies after a disturbance with significantly improved transient performance.

  10. The SMU Primary Mercury Manometer and its Comparison with Three Manometers of Different Design

    Farár, P.; Skrovánek, T.; Faltus, Z.; Chytil, M.


    After the CCM Medium Pressure Working Group intercomparison indicated that the SMU primary mercury manometer differed by more than 20 ppm from other national standards, attention was paid to determining and eliminating the possible sources of these deviations. These efforts included replacing or redesigning some of the manometer components. The modified manometer design is presented in this paper. A piston gauge has been calibrated in the absolute mode using nitrogen as a pressure media, with the primary standard manometers at four national standards laboratories: Slovenský Metrologický Ústav (SMU), Bratislava; Amt für Standardisierung, Messwesen und Warenprüfung (ASMW), Berlin; Physikalisch-Technische Bundesanstalt (PTB), Braunschweig; and the National Institute of Standards and Technology (NIST), Gaithersburg; over a period of six years. Each of these manometers is of a different design. This has provided a basis from which to determine how the design changes affect the SMU manometer performance. The results indicate that the previous systematic deviations have been eliminated in the upper pressure ranges. The results for all four manometers agree to within their claimed uncertainties, however at the lowest pressures significant differences still exist and require further investigation.

  11. Experience in design and startup of distillation towers in primary crude oil processing unit

    Lebedev, Y.N.; D' yakov, V.G.; Mamontov, G.V.; Sheinman, V.A.; Ukhin, V.V.


    This paper describes a refinery in the city of Mathura, India, with a capacity of 7 million metric tons of crude per year, designed and constructed to include the following units: AVT for primary crude oil processing; catalytic cracking; visbreaking; asphalt; and other units. A diagram of the atmospheric tower with stripping sections is shown, and the stabilizer tower is illustrated. The startup and operation of the AVT and visbreaking units are described, and they demonstrate the high reliability and efficiency of the equipment.

  12. In-service English language training for Italian Primary School Teachers An experience in syllabus design

    Barbara Dawes


    Full Text Available The aim of this paper is to report on an in-service English Language Teacher Training Programme devised for the Government project to equip Italian primary school teachers  with the skills to teach English. The paper focuses on the first phase of the project which envisaged research into the best training models and the preparation of appropriate  English Language syllabuses. In  the first three sections of the paper we report on the experience of designing the language syllabus. In the last section we suggest ways of using the syllabus as a tool for self reflective professional development.

  13. The Design of a Primary Flight Trainer using Concurrent Engineering Concepts

    Ladesic, James G.; Eastlake, Charles N.; Kietzmann, Nicholas H.


    Concurrent Engineering (CE) concepts seek to coordinate the expertise of various disciplines from initial design configuration selection through product disposal so that cost efficient design solutions may be achieve. Integrating this methodology into an undergraduate design course sequence may provide a needed enhancement to engineering education. The Advanced Design Program (ADP) project at Embry-Riddle Aeronautical University (EMU) is focused on developing recommendations for the general aviation Primary Flight Trainer (PFT) of the twenty first century using methods of CE. This project, over the next two years, will continue synthesizing the collective knowledge of teams composed of engineering students along with students from other degree programs, their faculty, and key industry representatives. During the past year (Phase I). conventional trainer configurations that comply with current regulations and existing technologies have been evaluated. Phase I efforts have resulted in two baseline concepts, a high-wing, conventional design named Triton and a low-wing, mid-engine configuration called Viper. In the second and third years (Phases II and III). applications of advanced propulsion, advanced materials, and unconventional airplane configurations along with military and commercial technologies which are anticipated to be within the economic range of general aviation by the year 2000, will be considered.

  14. User-centered design to improve clinical decision support in primary care.

    Brunner, Julian; Chuang, Emmeline; Goldzweig, Caroline; Cain, Cindy L; Sugar, Catherine; Yano, Elizabeth M


    A growing literature has demonstrated the ability of user-centered design to make clinical decision support systems more effective and easier to use. However, studies of user-centered design have rarely examined more than a handful of sites at a time, and have frequently neglected the implementation climate and organizational resources that influence clinical decision support. The inclusion of such factors was identified by a systematic review as "the most important improvement that can be made in health IT evaluations." (1) Identify the prevalence of four user-centered design practices at United States Veterans Affairs (VA) primary care clinics and assess the perceived utility of clinical decision support at those clinics; (2) Evaluate the association between those user-centered design practices and the perceived utility of clinical decision support. We analyzed clinic-level survey data collected in 2006-2007 from 170 VA primary care clinics. We examined four user-centered design practices: 1) pilot testing, 2) provider satisfaction assessment, 3) formal usability assessment, and 4) analysis of impact on performance improvement. We used a regression model to evaluate the association between user-centered design practices and the perceived utility of clinical decision support, while accounting for other important factors at those clinics, including implementation climate, available resources, and structural characteristics. We also examined associations separately at community-based clinics and at hospital-based clinics. User-centered design practices for clinical decision support varied across clinics: 74% conducted pilot testing, 62% conducted provider satisfaction assessment, 36% conducted a formal usability assessment, and 79% conducted an analysis of impact on performance improvement. Overall perceived utility of clinical decision support was high, with a mean rating of 4.17 (±.67) out of 5 on a composite measure. "Analysis of impact on performance

  15. Designing a multifaceted quality improvement intervention in primary care in a country where general practice is seeking recognition: the case of Cyprus

    Stoffers Henri E


    Full Text Available Abstract Background Quality Improvement Interventions require significant financial investments, and therefore demand careful consideration in their design in order to maximize potential benefits. In this correspondence we present the methodological approach of a multifaceted quality improvement intervention aiming to improve quality of care in primary care, properly tailored for a country such as Cyprus where general practice is currently seeking recognition. Methods Our methodological approach was focused on the design of an open label, community-based intervention controlled trial using all patients from two urban and two rural public primary care centers diagnosed with hypertension and type II diabetes mellitus. The design of our intervention was grounded on a strong theoretical framework that included the Unified Theory of Acceptance and Use of Technology, and the Chronic Care Model, which synthesize evidence-based system changes in accordance with the Theory of Planned Behavior and the Theory of Reasoned Action. The primary outcome measure was improvement in the quality of care for two chronic diseases evaluated through specific clinical indicators, as well as the patient satisfaction assessed by the EUROPEP questionnaire and additional personal interviews. Results We designed a multifaceted quality improvement intervention model, supported by a varying degree of scientific evidence, tailored to local needs and specific country characteristics. Overall, the main components of the intervention were the development and adoption of an electronic medical record and the introduction of clinical guidelines for the management of the targeted chronic diseases facilitated by the necessary model of organizational changes. Conclusion Health planners and policy makers need to be aware of the potential use of certain theoretical models and applied methodology as well as inexpensive tools that may be suitably tailored to the local needs, in order to

  16. Research and Development Projects with ICT and students as learning designers in Primary Schools

    Levinsen, Karin; Sørensen, Birgitte Holm; Tosca, Susana


    In this paper we present some methodological challenges that emerged during the process of shaping the research design for the comprehensive and complex research project Children as learning designers in a digital school. The project is the realization of our proposal to a research call from...... the Danish Ministry of Education named Development projects and pilot school experiments (Udviklingsprojekter med demonstrationsskoleforsøg vedr. it i folkeskolen – see Undervisningsministeriet 2013) in the spring 2013. The call was based on a governmental decision to allocate 500 million DKR to increase...... the use of ICT in the Danish primary school from 2012-2015 combined with an increased focus on fulfilling learning objectives and to build competencies. This effort is on the one side due to a decade of disappointing Danish PISA results regarding reading, writing and math; on the other side due...

  17. Design and testing of the U.S. Space Station Freedom primary propulsion system

    Morano, Joseph S.; Delventhal, Rex A.; Chilcot, Kimberly J.


    The primary propulsion system (PPS) for the Space Station Freedom is discussed in terms of salient design characteristics and key testing procedures. The rocket engine modules contain reboost and attitude control thrusters, and their designs are illustrated showing the mounting structures, thruster solenoid valves, and thrust chambers. The propellant tank assembly for storing gaseous N pressurant and hydrazine propellant is described as are the system avionics, thruster solenoid valves, and latching isolation valves. PPS testing conducted on the development systems includes the use of a propulsion-module development unit, a development test article, and system qualification testing. Specific test articles include functional heaters, mass/thermal simulated components, flight-quality structures, and software control operations.

  18. A novel design for a primary measurement standard for the quantity torque

    Taccola, G. M.; Leão, R. J.


    Primary standards are established using a reference measurement procedure. Through the realization of the definition of a given quantity they provide traceability in the metrology chain. Most torque standards use calibrated weights linked to a lever arm to provide known torques in the rotational axis of the device. These standards do not succeed to provide continuous torque values because of limitation in weights combination and the intrinsic incremental steps of the technique. In automatic machines this can be overcome but it requires a complex mechanical system to operate. In designs that use movable weights along the lever arm the determination of the length of the lever arm is a large source of errors. Zeroing the torque standard also represents a major problem. An innovative and functional design that aims to solve the aforementioned disadvantages is presented.

  19. Psychiatric Assessment and Screening for the Elderly in Primary Care: Design, Implementation, and Preliminary Results

    Robert C. Abrams


    Full Text Available Introduction. We describe the design and implementation of a psychiatric collaborative care model in a university-based geriatric primary care practice. Initial results of screening for anxiety and depression are reported. Methods and Materials. Screens for anxiety and depression were administered to practice patients. A mental health team, consisting of a psychiatrist, mental health nurse practitioner, and social worker, identified patients who on review of screening and chart data warranted evaluation or treatment. Referrals for mental health interventions were directed to members of the mental health team, primary care physicians at the practice, or community providers. Results. Subjects (N=1505 comprised 38.2% of the 3940 unique patients seen at the practice during the 4-year study period. 37.1% (N=555 screened positive for depression, 26.9% (N=405 for anxiety, and 322 (21.4% screened positive for both. Any positive score was associated with age (P<0.033, female gender (P<0.006, and a nonsignificant trend toward living alone (P<0.095. 8.87% had suicidal thoughts. Conclusions. Screening captured the most affectively symptomatic patients, including those with suicidal ideation, for intervention. The partnering of mental health professionals and primary care physicians offers a workable model for addressing the scarcity of expertise in geriatric psychiatry.

  20. Partnership effectiveness in primary community care networks: A national empirical analysis of partners' coordination infrastructure designs.

    Lin, Blossom Yen-Ju; Lin, Yung-Kai; Lin, Cheng-Chieh


    Previous empirical and managerial studies have ignored the effectiveness of integrated health networks. It has been argued that the varying definitions and strategic imperatives of integrated organizations may have complicated the assessment of the outcomes/performance of varying models, particularly when their market structures and contexts differed. This study aimed to empirically verify a theoretical perspective on the coordination infrastructure designs and the effectiveness of the primary community care networks (PCCNs) formed and funded by the Bureau of National Health Insurance since March 2003. The PCCNs present a model to replace the traditional fragmented providers in Taiwan's health care. The study used a cross-sectional mailed survey designed to ascertain partnership coordination infrastructure and integration of governance, clinical care, bonding, finances, and information. The outcome indicators were PCCNs' perceived performance and willingness to remain within the network. Structural equation modeling examined the causal relationships, controlling for organizational and environmental factors. Primary data collection occurred from February through December 2005, via structured questionnaires sent to 172 PCCNs. Using the individual PCCN as the unit of analysis, the results found that a network's efforts regarding coordination infrastructures were positively related to the PCCN's perceived performance and willingness to remain within the network. In addition, PCCNs practicing in rural areas and in areas with higher density of medical resources had better perceived effectiveness and willingness to cooperate in the network.Practical Implication: The lack of both an operational definition and an information about system-wide integration may have obstructed understanding of integrated health networks' organizational dynamics. This study empirically examined individual PCCNs and offers new insights on how to improve networks' organizational design and

  1. Design for life-cycle profit with simultaneous consideration of initial manufacturing and end-of-life remanufacturing

    Kwak, Minjung; Kim, Harrison


    Remanufacturing is emerging as a promising solution for achieving green, profitable businesses. This article considers a manufacturer that produces new products and also remanufactured versions of the new products that become available at the end of their life cycle. For such a manufacturer, design decisions at the initial design stage determine both the current profit from manufacturing and future profit from remanufacturing. To maximize the total profit, design decisions must carefully consider both ends of product life cycle, i.e. manufacturing and end-of-life stages. This article proposes a decision-support model for the life-cycle design using mixed-integer nonlinear programming. With an aim to maximize the total life-cycle profit, the proposed model searches for an (at least locally) optimal product design (i.e. design specifications and the selling price) for the new and remanufactured products. It optimizes both the initial design and design upgrades at the end-of-life stage and also provides corresponding production strategies, including production quantities and take-back rate. The model is extended to a multi-objective model that maximizes both economic profit and environmental-impact saving. To illustrate, the developed model is demonstrated with an example of a desktop computer.

  2. Analysis of Environmental Issues Related to Small-Scale Hydroelectric Development II: Design Consideration for Passing Fish Upstream Around Dams

    Hildebrandt, S. G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bell, M. C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Anderson, J. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Richey, E. P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Parkhurst, Z. E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)


    The purpose of this report is to provide general information for use by potential developers of small scale hydroelectric projects that will include facilities to pass migrating fish upstream around dams. The document is not intended to be a textbook on design of fish passage facilities, but rather to be a general guide to some factors that are important when designing such facilities.

  3. Redesigning Terraced Social Housing in the UK for Flexibility Using Building Energy Simulation with Consideration of Passive Design

    Hasim Altan


    Full Text Available A chosen case study house forms the basis of this paper, which is a pilot energy-efficient social housing project, completed by one of the largest housing developers in the UK. The main aim of this study is to inform the redesign of flexible energy-efficient housing units. The housing, designed for social tenants, was built by the Accent Group in 2005, using modern construction methods and sustainable materials, based on extensive research from the adaptable and “Grow Home” principles of Avi Friedman as well as open building implementation. The first pilot scheme was designed in collaboration with the Building Energy Analysis Unit at the University of Sheffield, together with the Goddard Wybor Practise, and was a successful housing development with respect to being environmentally friendly and a low-energy design scheme for the UK climate. This paper presents redesigning of flexible terraced housing units, and their performance evaluation, using a building simulation method as well as the passive-house planning package. The aim was to plan a row of terraced houses that can not only utilize a flexible design concept in floor planning layout, but also to reduce energy consumption with a passive design with particular attention paid to material selection. In addition, building simulation work has been carried out with the use of DesignBuilder software for both thermal and energy performance evaluation. The study examines the annual energy performance and comfort conditions in the designed house to be situated in the Northeast of England, UK. A terraced house unit design is considered a flexible home that can adjust to the needs of different tenants for the purpose of achieving a sustainable building under different aspects, such as low energy, low carbon, use of renewables, and low impact materials, with flexibility by design.

  4. Composition induced design considerations for InP/Ga xIn 1- xAs heterojunction bipolar transistors

    Mohammad, S. Noor


    Several design principles based on compositional grading and heavy doping of the base region of a heterojunction bipolar transistor (HBT) have been presented. Physical and technological advantages underlying composition induced design criteria of InP/Ga xIn 1- xAs HBTs have been discussed. A number of issues such as superlattice based grading in the base region, base resistance vs base region grading, the emitter-base junction design, tradeoffs between base region grading and the nonuniform doping of the base region, and the surface recombination at the external base region, have been articulated.

  5. Assessment of LWR spent fuel disposal options. Volume 3. Study bases and system design considerations (Appendices). Technical report


    Volume 3 (Appendices) provides a tabulation of the bases and assumptions used in the study as well as preconceptual design description and cost estimates of the facilities and transportation systems necessary to implement the various study cases.

  6. Some Considerations on Simple Non-Linear Magnetic Analysis-Based Optimum Design of Multi-Pole Permanent Magnet Machines

    Kano, Yoshiaki; Kosaka, Takashi; Matsui, Nobuyuki

    This paper presents a simple non-linear magnetic analysis-based optimum design of a multi-pole permanent magnet machine as an assistant design tool of 3D-FEM. The proposed analysis is based on the equivalent magnetic circuit and the air gap permeance model between the stator and rotor teeth of the motor, taking into account the local magnetic saturation in the pointed end of teeth. The availability of the proposed analysis is verified by comparing with 3D-FEM analysis from the standpoints of the torque calculation accuracy for the variations of design free parameter and the computation time. After verification, the proposed analysis-based optimum design of the dimensions of permanent magnet is examined, by which the minimization of magnet volume is realized while keeping torque/current ratio at the specified value.

  7. Social housing in Costa Rica's warm humid climate : strategies and considerations for passive design

    Smith-Masis, M. [Architectural Association, London (United Kingdom). Sustainable and Environmental Design Programme


    The demand for housing in Costa Rica is growing but affordability still prevents low income families from obtaining quality homes. Although local authorities have made significant effort to face housing demand, social housing projects do not consider climate adaptation, users necessities nor thermal comfort. This is evident in warm-humid regions where poor design is often used. This paper aims to set design recommendations and environmental guidelines for social housing projects for the warm humid regions of Costa-Rica, where openness and shading becomes a main issue. Such concepts will be explored in regards of passive design strategies and thermal comfort. It was concluded that Costa Rica's social housing scenario should consider design strategies that optimize effective use of spaces, natural ventilation and shading in order to provide comfort with low energy use. The design recommendations aim to have an intrinsic relationship within bioclimatic design, comfort assessments and sustainable architecture, where social housing dwellings enhance and promote quality and dignity for the occupants through social awareness and sustainable resources. 9 refs., 6 figs.

  8. Primary Stability Recognition of the Newly Designed Cementless Femoral Stem Using Digital Signal Processing

    Salleh, Sh-Hussain; Hamedi, Mahyar; Zulkifly, Ahmad Hafiz; Lee, Muhammad Hisyam; Mohd Noor, Alias; Harris, Arief Ruhullah A.; Abdul Majid, Norazman


    Stress shielding and micromotion are two major issues which determine the success of newly designed cementless femoral stems. The correlation of experimental validation with finite element analysis (FEA) is commonly used to evaluate the stress distribution and fixation stability of the stem within the femoral canal. This paper focused on the applications of feature extraction and pattern recognition using support vector machine (SVM) to determine the primary stability of the implant. We measured strain with triaxial rosette at the metaphyseal region and micromotion with linear variable direct transducer proximally and distally using composite femora. The root mean squares technique is used to feed the classifier which provides maximum likelihood estimation of amplitude, and radial basis function is used as the kernel parameter which mapped the datasets into separable hyperplanes. The results showed 100% pattern recognition accuracy using SVM for both strain and micromotion. This indicates that DSP could be applied in determining the femoral stem primary stability with high pattern recognition accuracy in biomechanical testing. PMID:24800230

  9. Primary, secondary, and tertiary amines for CO2 capture: designing for mesoporous CO2 adsorbents.

    Ko, Young Gun; Shin, Seung Su; Choi, Ung Su


    CO(2) emissions, from fossil-fuel-burning power plants, the breathing, etc., influence the global worming on large scale and the man's work efficiency on small scale. The reversible capture of CO(2) is a prominent feature of CO(2) organic-inorganic hybrid adsorbent to sequester CO(2). Herein, (3-aminopropyl) trimethoxysilane (APTMS), [3-(methylamino)propyl] trimethoxysilane (MAPTMS), and [3-(diethylamino) propyl] trimethoxysilane (DEAPTMS) are immobilized on highly ordered mesoporous silicas (SBA-15) to catch CO(2) as primary, secondary, and tertiary aminosilica adsorbents. X-ray photoelectron spectroscopy was used to analyze the immobilized APTMS, MAPTMS, and DEAPTMS on the SBA-15. We report an interesting discovery that the CO(2) adsorption and desorption on the adsorbent depend on the amine type of the aminosilica adsorbent. The adsorbed CO(2) was easily desorbed from the adsorbent with the low energy consumption in the order of tertiary, secondary, and primary amino-adsorbents while the adsorption amount and the bonding-affinity increased in the reverse order. The effectiveness of amino-functionalized (1(o), 2(o), and 3(o) amines) SBA-15s as a CO(2) capturing agent was investigated in terms of adsorption capacity, adsorption-desorption kinetics, and thermodynamics. This work demonstrates apt amine types to catch CO(2) and regenerate the adsorbent, which may open new avenues to designing "CO(2) basket".

  10. A Dynamic Design Space for Primary Drying During Batch Freeze-Drying

    Mortier, Séverine Thérèse F C; Van Bockstal, Pieter Jan; Nopens, Ingmar;


    model is used to determine the optimal values for the adaptable variables, hereby accounting for the uncertainty in all involved model parameters. A dynamic Design Space was constructed with a risk of failure acceptance level of 0.01%, i.e. a 'zero-failure' situation. Even for a risk of failure of 0......Biopharmaceutical products are emerging within the pharmaceutical industry. However, biopharmaceuticals are often unstable in aqueous solution. Freeze-drying (lyophilisation) is the preferred method to achieve a stable product with an increased shelf-life. During batch freeze-drying, there are only...... two adaptable process variables, i.e. the shelf temperature and the pressure in the drying chamber. The value of both should be optimized, preferably in a dynamic way, to minimise the primary drying time while respecting process and equipment constraints and ensuring end product quality. A mechanistic...

  11. Analysis and Design of Fully Integrated Planar Magnetics for Primary-Parallel Isolated Boost Converter

    Ouyang, Ziwei; Sen, Gökhan; Thomsen, Ole Cornelius;


    -I-E core geometry, reducing the total ferrite volume and core loss. The transformer windings are symmetrically distributed into the outer legs of E-cores and the inductor windings are wound on the center legs of E-cores with air gaps. Therefore, the inductor and the transformer can be operated...... and switching loss of MOSFETs are analyzed in-depth in this work as well. To verify the validity of the design approach, a 2-kW prototype converter with two primary power stages is implemented for a fuel cell fed traction applications with 20-50 V input and 400-V output. An efficiency of 95.9% can be achieved...

  12. Design Development Test and Evaluation (DDT and E) Considerations for Safe and Reliable Human Rated Spacecraft Systems

    Miller, James; Leggett, Jay; Kramer-White, Julie


    A team directed by the NASA Engineering and Safety Center (NESC) collected methodologies for how best to develop safe and reliable human rated systems and how to identify the drivers that provide the basis for assessing safety and reliability. The team also identified techniques, methodologies, and best practices to assure that NASA can develop safe and reliable human rated systems. The results are drawn from a wide variety of resources, from experts involved with the space program since its inception to the best-practices espoused in contemporary engineering doctrine. This report focuses on safety and reliability considerations and does not duplicate or update any existing references. Neither does it intend to replace existing standards and policy.

  13. Design consideration of a multipinhole collimator with septa for ultra high-resolution silicon drift detector modules

    Min, Byung Jun [Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Gangnam-Gu, Seoul 135-710 (Korea, Republic of); Choi, Yong [Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Gangnam-Gu, Seoul 135-710 (Korea, Republic of)], E-mail:; Lee, Nam-Yong [School of Computer Aided Science, Institute of Basic Science, Inje University, Gimhae, Gyeongnam 621-749 (Korea, Republic of); Lee, Kisung [Department of Radiologic Science, Korea University, Seoul 136-703 (Korea, Republic of); Ahn, Young Bok [Department of Electronic Engineering, Konkuk University, Seoul 143-701 (Korea, Republic of); Joung, Jinhun [Molecular Imaging, Siemens Medical Solutions USA, Inc., Hoffman Estates, IL 60195 (United States)


    The aim of this study was to design a multipinhole (MP) collimator with lead vertical septa coupled to a high-resolution detector module containing silicon drift detectors (SDDs) with an intrinsic resolution approaching the sub-millimeter level. Monte Carlo simulations were performed to determine pinhole parameters such as pinhole diameter, focal length, and number of pinholes. Effects of parallax error and collimator penetration were investigated for the new MP collimator design. The MP detector module was evaluated using reconstructed images of resolution and mathematical cardiac torso (MCAT) phantoms. In addition, the reduced angular sampling effect was investigated over 180 deg. The images were reconstructed using dedicated maximum likelihood expectation maximization (MLEM) algorithm. An MP collimator with 81-pinhole was designed with a 2-mm-diameter pinhole and a focal length of 40 mm . Planar sensitivity and resolution obtained using the devised MP collimator were 3.9 cps/{mu}Ci and 6 mm full-width at half-maximum (FWHM) at a 10 cm distance. The parallax error and penetration ratio were significantly improved using the proposed MP collimation design. The simulation results demonstrated that the proposed MP detector provided enlarged imaging field of view (FOV) and improved the angular sampling effect in resolution and MCAT phantom studies. Moreover, the novel design enables tomography images by simultaneously obtaining eight projections with eight-detector modules located along the 180 deg. orbit surrounding a patient, which allows designing of a stationary cardiac SPECT. In conclusion, the MP collimator with lead vertical septa was designed to have comparable system resolution and sensitivity to those of the low-energy high-resolution (LEHR) collimator per detector. The system sensitivity with an eight-detector configuration would be four times higher than that with a standard dual-detector cardiac SPECT.

  14. SKALA, a log-periodic array antenna for the SKA-low instrument: design, simulations, tests and system considerations

    Acedo, E de Lera; Troop, N; Drought, N; Faulkner, A J


    The very demanding requirements of the SKA-low instrument call for a challenging antenna design capable of delivering excellence performance in radiation patterns, impedance matching, polarization purity, cost, longevity, etc. This paper is devoted to the development (design and test of first prototypes) of an active ultra-wideband antenna element for the low-frequency instrument of the SKA radio telescope. The antenna element and differential low noise amplifier described here were originally designed to cover the former SKA-low band (70-450MHz) but it is now aimed to cover the re-defined SKA-low band (50-350MHz) and furthermore the antenna is capable of performing up to 650MHz with the current design. The design is focused on maximum sensitivity in a wide field of view (+/- 45deg from zenith) and low cross-polarization ratios. Furthermore, the size and cost of the element has to be kept to a minimum as millions of these antennas will need to be deployed for the full SKA in very compact configurations. The p...

  15. 78 FR 47191 - Air Quality Designations for the 2010 Sulfur Dioxide (SO2) Primary National Ambient Air Quality...


    ... AGENCY 40 CFR Part 81 RIN 2060-AR18 Air Quality Designations for the 2010 Sulfur Dioxide (SO ) Primary National Ambient Air Quality Standard AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: This rule establishes air quality designations for certain areas in the United States for the...

  16. Organizations as Social Inventions: Some Considerations for Those Who Would Design Schools To Serve Human Ends. Revised.

    Greenfield, T. Barr

    In searching for a concept of organization which recognizes its base in human action rather than in objective structure, the author draws on a European tradition stemming from the works of Max Weber. This tradition, combined with examples of organizational life in schools, serves to identify implications for those who attempt to design better…

  17. A strategy for a thorough beam stability and aperture analysis for a storage ring from design considerations

    Chattopadhyay, S.


    An outline of a possible approach to understanding and analyzing beam stability and related aperture as thoroughly as one can using tracking and all the other available analytic tools to date is presented in the context of designing any particular storage ring. 8 refs., 3 figs.

  18. 电磁兼容性(EMC)设计需要考虑的问题%EMC Design Considerations

    Atmel Inc.


    阐述了电磁兼容(EMC)设计的原则,指出了产品EMC现象的若干主要原因,提出了相应的方法和措施%The paper expounds the principle of EMC design, main cause of EMC phenomenaand proposes a few of solution for EMC

  19. Universal Design for Learning and Assistive Technology: Leadership Considerations for Promoting Inclusive Education in Today's Secondary Schools

    Messinger-Willman, Jaime; Marino, Matthew T.


    The increased number of students with learning disabilities in general education secondary school classrooms presents complex challenges for today's educators. This article describes how the Universal Design for Learning theoretical framework can be used with assistive technology to enhance educational opportunities for secondary students with…

  20. Designing Energy Supply Chains with the P-Graph Framework under Cost Constraints andSustainability Considerations

    A computer-aided methodology for designing sustainable supply chains is presented using the P-graph framework to develop supply chain structures which are analyzed using cost, the cost of producing electricity, and two sustainability metrics: ecological footprint and emergy. They...