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Sample records for previous investigation results

  1. A comparison of results from previous and present investigations of benthic macroinvertebrates in the small and shallow Lake Shoji, Fuji Five Lakes, Japan

    Directory of Open Access Journals (Sweden)

    Kimio Hirabayashi

    2012-10-01

    Full Text Available In order to clarify the current status of the benthic community of Lake Shoji, and to examine the difference with the last quantitative data of the lake by Miyadi (1932 and Kitagawa (1973, the distribution of benthic macroinvertebrates in this lake was studied. Also, a comparison of the benthic fauna and density was made between the present and previous studies, with a discussion concerning the succession of benthic macroinvertebrates in relation to changes in the lake bottom environment. On March 1, 2010, and September 7, 2011, bathymetrical sampling surveys were carried out using a standard Ekman-Birge grab at each of the 7 locations in Lake Shoji. The average densities of the benthic communities for all the stations were 4,107 inds. m-2, comprised principally of oligochaetes 50.2%, chironomids 48.6%, and chaoborid 1.2% in March 2010, whereas in September 2011 the average density was 1,185 inds. m-2, and mostly comprised of oligochaetes 86.6% and chironomids 13.4%. On the other hand, the average biomasses (wet weight of these benthic macroinvertebrates in March 2010 were composed of 33.3% oligochaetes, 62.8% chironomid larvae, and 3.9% chaoborid larvae, as opposed to 48.8% oligochaetes and 51.2% chironomid larvae, respectively, in September 2011. Propsilocerus akamusi (Tokunaga, 1938 and Procladius sp. of chironomid larvae were the dominant species, making up 10.0% and 17.6%, respectively, of the total chironomid fauna in density, and 83.2% and 9.2% in biomass in March 2010. The mean density of P. akamusi was about 2.5 times higher than that reported by Kitagawa in the 1970s. In recent years, the number of P. akamusi larvae has tended to increase; they are widely distributed, and the anoxic-layer and anaerobic-layer are thickening, especially during summer to late fall in Lake Shoji, suggesting that the lake is in the process of eutrophication.doi: 10.5324/fn.v31i0.1365.Published online: 17 October 2012

  2. Docking and Molecular Dynamics Calculations of Some Previously Studied and newly Designed Ligands to Catalytic Core Domain of HIV-1 Integrase and an Investigation to Effects of Conformational Changes of Protein on Docking Results

    Directory of Open Access Journals (Sweden)

    Selami Ercan

    2016-10-01

    Full Text Available Nowadays, AIDS still remains as a worldwide pandemic and continues to cause many death which arise from HIV-1 virus. For nearly 35 years, drugs that target various steps of virus life cycle have been developed. HIV-1 integrase is the one of these steps which is essential for virus life cycle. Computer aided drug design is being used in many drug design studies as also used in development of the first HIV-1 integrase inhibitor Raltegravir. In this study 3 ligands which are used as HIV-1 integrase inhibitors and 4 newly designed ligands were docked to catalytic core domain of HIV-1 integrase. Each of ligands docked to three different conformations of protein. Prepared complexes (21 item were carried out by 50 ns MD simulations and results were analyzed. Finally, the binding free energies of ligands were calculated. Hereunder, it was determined that designed ligands L01 and L03 gave favorable results. The questions about the ligands which have low docking scores in a conformation of protein could give better scores in another conformation of protein and if the MD simulations carry the different oriented and different localized ligands in same position at the end of simulation were answered.

  3. Investigating the effect of previous treatments on wheat biomass over multiple spatial frequencies

    Science.gov (United States)

    Milne, A. E.; Castellanos, M. T.; Cartagena, M. C.; Tarquis, A. M.; Lark, R. M.

    2010-09-01

    In this study we use the maximum overlap discrete packet transform (MODWPT) to investigate residual effects on wheat biomass of fertigation treatments applied to a previous crop. The wheat crop covered nine subplots from a previous experiment on melon response to fertigation. Each subplot had previously received a different level of applied nitrogen. Many factors affect wheat biomass, causing it to vary at different spatial frequencies. We hypothesize that these will include residual effects from fertilizer application (at relatively low spatial frequencies) and the local influence of individual plants from the previous melon crop (at high frequency). To test this hypothesis we use the MODWPT to identify the dominant spatial frequencies of wheat biomass variation, and analyse the relationship to both the previous fertilizer application and the location of individual melon plants in the previous crop. The MODWPT is particularly appropriate for this because it allows us first to identify the key spatial frequencies in the wheat biomass objectively and to analyse them, and their relationship to hypothesized driving factors without any assumptions of uniformity (stationarity) of wheat-biomass variation. The results showed that the applied nitrogen dominated the wheat biomass response, and that there was a noticeable component of wheat-biomass variation at the spatial frequency that corresponds to the melon cropping. We expected wheat biomass to be negatively correlated with the position of melons in the previous crop, due to uptake of the applied nitrogen. The MODWPT, which allows us to detect changes in correlation between variables at different frequencies, showed that such a relationship was found across part of the experiment but not uniformly.

  4. Priming in word stem completion tasks: comparison with previous results in word fragment completion tasks

    Directory of Open Access Journals (Sweden)

    Maria Jose Soler

    2015-08-01

    Full Text Available This study investigates priming in an implicit Word Stem Completion (WSC task. A total of 305 participants performed a WSC task in two phases (study and test. The test phase included 63 unique-solution stems and 63 multiple-solution stems. After confirming the presence of priming (mean = 0.22, analysis revealed that it was stronger in the case of multiple-solution stems, indicating that the stems were not a homogeneous group of stimuli. Thus, further analyses were performed only for the data of the unique-solution stems. The correlations between priming and a set of conceptual (familiarity, frequency of use, number of meanings and non-conceptual (letters/blanks ratio and difficulty of completed variables showed significant relationships between two conceptual variables (familiarity and frequency and priming. Difficulty was also significantly correlated with priming. The most familiar and frequent words were those that produced a greater magnitude of priming. At the same time, the most difficult stems were those generating more priming. A regression analysis showed that the difficulty of completing a stem was the strongest predictor of priming. When difficulty was the dependent variable in the regression analysis, the significant variables in the regression were familiarity and letters-blanks ratio. Finally, a comparison was made between these results and those obtained in a previous study of WFC by Soler et al. (2009 in which the same words and procedure were employed. A comparison of results from these two sets of data suggested that the only relevant difference between the two tasks was the influence of the variable letters-blanks ratio. This perceptual variable had a significant correlation with priming only in the WFC task. These results highlight the importance of controlling the characteristics (conceptual and non-conceptual of stimuli used in WFC and WSC tasks when exploring the nature of priming.

  5. Priming in word stem completion tasks: comparison with previous results in word fragment completion tasks.

    Science.gov (United States)

    Soler, María J; Dasí, Carmen; Ruiz, Juan C

    2015-01-01

    This study investigates priming in an implicit word stem completion (WSC) task by analyzing the effect of linguistic stimuli characteristics on said task. A total of 305 participants performed a WSC task in two phases (study and test). The test phase included 63 unique-solution stems and 63 multiple-solution stems. Analysis revealed that priming (mean = 0.22) was stronger in the case of multiple-solution stems, indicating that they were not a homogeneous group of stimuli. Thus, further analyses were performed only for the data of the unique-solution stems. Correlations between priming and familiarity, frequency of use, and baseline completion were significant. The less familiar words, which were less frequent, had higher priming values. At the same time, the stems with lower baseline completion generated more priming. A regression analysis showed that baseline completion was the only significant predictor of priming, suggesting that the previous processing of the stimuli had a greater impact on the stimuli with low baseline performance. At the same time, baseline completion showed significant positive correlations with familiarity and frequency of use, and a negative correlation with length. When baseline completion was the dependent variable in the regression analysis, the significant variables in the regression were familiarity and length. These results were compared with those obtained in a study using word fragment completion (WFC) by Soler et al. (2009), in which the same words and procedure were employed. Analysis showed that the variables that correlated with priming were the same as in the WSC task, and that completion baseline was the variable that showed the greatest predictive power of priming. This coincidence of results obtained with WFC and WSC tasks highlights the importance of controlling the characteristics of the stimuli used when exploring the nature of priming.

  6. UsToo PC-SPES surveys: review of studies and update of previous survey results.

    Science.gov (United States)

    Porterfield, H

    2000-01-01

    In 1997, we resolved to survey UsToo members and other men known at that time to be taking PC-SPES, a Chinese herb combination that contains eight herbs: chrysanthemum, dyers woad, licorice, reishi, san-qi ginseng, rabdosia, saw palmetto, and baikal skullcap. The survey showed positive results, with respondents experiencing a decline in serum prostate specific antigen (PSA), most to the undetectable range. Of these patients, 88% maintained a low PSA concentration, whereas 12% had a rise from nadir. These results made it obvious that we should obtain follow-up reports from the respondents. We therefore conducted a second survey, this time finding 93% of the respondents with positive results and only 7% reporting a rise in PSA after the initial lowering with PC-SPES. Even though there are some side effects, a great majority of men are realizing good PSA control while taking the capsules, and some of the respondents are now into their fourth year of PC-SPES use. Currently, several institutions are investigating the biology of this Chinese herb combination. Although there is some estrogenic effect, there are other potential mechanisms of action to enable this product to control PSA, not only in newly diagnosed cancer, but also in longer-term use.

  7. Investigating physiological methods to determine previous exposure of immature insects to ionizing radiation

    International Nuclear Information System (INIS)

    Mansour, M.Y.

    2001-01-01

    Effect of gamma radiation on phenoloxidase activity in codling moth, Cydia pomonella L., larvae was investigated. Phenoloxidase activity was determined spectrophotometrically by measuring the increase in optical density at 490 nm, or by observing the degree of melanization in larvae killed by freezing. Results showed that, in unirradiated larvae, phenoloxidase activity could be detected in 7 day old larvae and activity continued to increase throughout the larval stage. This increase was not observed when larvae were irradiated with a minimum dose of 50 Gy during the 1st week of their development. However, irradiating larvae in which enzyme activity was already high (24 week old) did not eliminate the activity but reduced further increase. Larval melanization studies were in general agreement with the results of the phenoloxidase assay. (author)

  8. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil

    CSIR Research Space (South Africa)

    Van Greunen, DG

    2017-02-01

    Full Text Available A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug...

  9. Initial results of CyberKnife treatment for recurrent previously irradiated head and neck cancer

    International Nuclear Information System (INIS)

    Himei, Kengo; Katsui, Kuniaki; Yoshida, Atsushi

    2003-01-01

    The purpose of this study was to evaluate the efficacy of CyberKnife for recurrent previously irradiated head and neck cancer. Thirty-one patients with recurrent previously irradiated head and neck cancer were treated with a CyberKnife from July 1999 to March 2002 at Okayama Kyokuto Hospital were retrospectively studied. The accumulated dose was 28-80 Gy (median 60 Gy). The interval between CyberKnife treatment and previous radiotherapy was 0.4-429.5 months (median 16.3 months). Primary lesions were nasopharynx: 7, maxillary sinus: 6, tongue: 5, ethmoid sinus: 3, and others: 1. The pathology was squamous cell carcinoma: 25, adenoid cystic carcinoma: 4, and others: 2. Symptoms were pain: 8, and nasal bleeding: 2. The prescribed dose was 15.0-40.3 Gy (median 32.3 Gy) as for the marginal dose. The response rate (complete response (CR)+partial response (PR)) and local control rate (CR+PR+no change (NC)) was 74% and 94% respectively. Pain disappeared for 4 cases, relief was obtained for 4 cases and no change for 2 cases and nasal bleeding disappeared for 2 cases for an improvement of symptoms. An adverse effects were observed as mucositis in 5 cases and neck swelling in one case. Prognosis of recurrent previously irradiated head and neck cancer was estimated as poor. Our early experience shows that CyberKnife is expected to be feasible treatment for recurrent previously irradiated head and neck cancer, and for the reduction adverse effects and maintenance of useful quality of life (QOL) for patients. (author)

  10. Previous treatment influences fingolimod efficacy in relapsing-remitting multiple sclerosis: results from an observational study.

    Science.gov (United States)

    Baldi, Eleonora; Guareschi, Angelica; Vitetta, Francesca; Senesi, Caterina; Curti, Erica; Montepietra, Sara; Simone, Anna Maria; Immovilli, Paolo; Caniatti, Luisa; Tola, Maria Rosaria; Pesci, Ilaria; Montanari, Enrico; Sola, Patrizia; Granella, Franco; Motti, Luisa; Ferraro, Diana

    2014-09-01

    Fingolimod (FTY) is licensed as a disease-modifying treatment in highly active relapsing-remitting multiple sclerosis. The aim of the study was to evaluate the efficacy and safety of FTY in a real-life setting and to explore the possible role of clinical and MRI parameters, including previous treatment type, in predicting its efficacy. Clinical and MRI data was collected on 127 patients assigned to treatment with FTY in six multiple sclerosis centers in Emilia-Romagna, Italy, between August 2011 and June 2013. During a mean follow-up period of 10 months (range 1-22), we observed a total of 47 relapses in 39 patients (30.7%); new T2 lesions or gadolinium-enhancing (Gd+) lesions were present at follow-up MRI in 32/71 patients (45%). Expanded disability status scale (EDSS) at the end of the follow-up period was not different when compared to the baseline EDSS. Serious adverse events occurred in three patients (2.4%). A higher proportion of patients previously treated with natalizumab showed clinical (41%) or MRI activity (54%). Previous treatment with natalizumab increased the risk of a relapse within 30 days (versus immunomodulatory drugs; OR: 4.3; p = 0.011) and at survival analysis (versus remaining patients; HR: 1.9; p = 0.046). Study limitations include a small population sample, a short observation period with variable timing of follow-up MRI and different baseline characteristics of patients previously treated with natalizumab compared to those treated with immunomodulatory drugs. This study confirms the efficacy of FTY in reducing relapse rate in patients previously treated with immunomodulatory drugs, while it seems to be less effective in patients discontinuing natalizumab. Due to the short duration of follow-up it is not possible to evaluate disability progression; however, no difference was observed between the groups.

  11. False-Positive Xpert MTB/RIF Results in Retested Patients with Previous Tuberculosis: Frequency, Profile, and Prospective Clinical Outcomes.

    Science.gov (United States)

    Theron, Grant; Venter, Rouxjeane; Smith, Liezel; Esmail, Aliasgar; Randall, Philippa; Sood, Vishesh; Oelfese, Suzette; Calligaro, Greg; Warren, Robin; Dheda, Keertan

    2018-03-01

    Globally, Xpert MTB/RIF (Xpert) is the most widely used PCR test for the diagnosis of tuberculosis (TB). Positive results in previously treated patients, which are due to old DNA or active disease, are a diagnostic dilemma. We prospectively retested sputum from 238 patients, irrespective of current symptoms, who were previously diagnosed to be Xpert positive and treated successfully. Patients who retested as Xpert positive and culture negative were exhaustively investigated (repeat culture, chest radiography, bronchoscopy with bronchoalveolar lavage, long-term clinical follow-up). We evaluated whether the duration since previous treatment completion, mycobacterial burden (the Xpert cycle threshold [ C T ] value), and reclassification of Xpert-positive results with a very low semiquantitation level to Xpert-negative results reduced the rate of false positivity. A total of 229/238 (96%) of patients were culture negative. Sixteen of 229 (7%) were Xpert positive a median of 11 months (interquartile range, 5 to 19 months) after treatment completion. The specificity was 93% (95% confidence interval [CI], 89 to 96%). Nine of 15 (40%) Xpert-positive, culture-negative patients reverted to Xpert negative after 2 to 3 months (1 patient declined further participation). Patients with false-positive Xpert results had a lower mycobacterial burden than patients with true-positive Xpert results ( C T , 28.7 [95% CI, 27.2 to 30.4] versus 17.6 [95% CI, 16.9 to 18.2]; P < 0.001), an increased likelihood of a chest radiograph not compatible with active TB (5/15 patients versus 0/5 patients; P = 0.026), and less-viscous sputum (15/16 patients versus 2/5 patients whose sputum was graded as mucoid or less; P = 0.038). All patients who initially retested as Xpert positive and culture negative ("Xpert false positive") were clinically well without treatment after follow-up. The duration since the previous treatment poorly predicted false-positive results (a duration of ≤2 years identified

  12. Previous antibiotic exposure and antimicrobial resistance in invasive pneumococcal disease: results from prospective surveillance.

    Science.gov (United States)

    Kuster, Stefan P; Rudnick, Wallis; Shigayeva, Altynay; Green, Karen; Baqi, Mahin; Gold, Wayne L; Lovinsky, Reena; Muller, Matthew P; Powis, Jeff E; Rau, Neil; Simor, Andrew E; Walmsley, Sharon L; Low, Donald E; McGeer, Allison

    2014-10-01

    Estimating the risk of antibiotic resistance is important in selecting empiric antibiotics. We asked how the timing, number of courses, and duration of antibiotic therapy in the previous 3 months affected antibiotic resistance in isolates causing invasive pneumococcal disease (IPD). We conducted prospective surveillance for IPD in Toronto, Canada, from 2002 to 2011. Antimicrobial susceptibility was measured by broth microdilution. Clinical information, including prior antibiotic use, was collected by chart review and interview with patients and prescribers. Clinical information and antimicrobial susceptibility were available for 4062 (90%) episodes; 1193 (29%) of episodes were associated with receipt of 1782 antibiotic courses in the prior 3 months. Selection for antibiotic resistance was class specific. Time elapsed since most recent antibiotic was inversely associated with resistance (cephalosporins: adjusted odds ratio [OR] per day, 0.98; 95% confidence interval [CI], .96-1.00; P = .02; macrolides: OR, 0.98; 95% CI, .96-.99; P = .005; penicillins: OR [log(days)], 0.62; 95% CI, .44-.89; P = .009; fluoroquinolones: profile penalized-likelihood OR [log(days)], 0.62; 95% CI, .39-1.04; P = .07). Risk of resistance after exposure declined most rapidly for fluoroquinolones and penicillins and reached baseline in 2-3 months. The decline in resistance was slowest for macrolides, and in particular for azithromycin. There was no significant association between duration of therapy and resistance for any antibiotic class. Too few patients received multiple courses of the same antibiotic class to assess the significance of repeat courses. Time elapsed since last exposure to a class of antibiotics is the most important factor predicting antimicrobial resistance in pneumococci. The duration of effect is longer for macrolides than other classes. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved

  13. [Investigation on the approach of delivery after previous cesarean section of Xinjiang Uyghur women].

    Science.gov (United States)

    Ding, Xin; Aimainilezi, Adalaiti; Jin, Yan; Abudula, Wuriguli; Yin, Chenghong

    2014-10-01

    To explore the appropriate approach of delivery after cesarean section of Uyghur women in primary hospitals in Xinjiang Uyghur Autonomous Region. A total of 5 154 women delivered in Luopu County People Hospital, Hetian Prefecture, Xinjiang Uyghur Autonomous Region from January 2011 to December 2012. Among them, 178 Uyghur women had cesarean section history. The interval between the previous cesarean section and this delivery varied from 1 year to 17 years. The number of cases attempting vaginal labor and the indications of the previous cesarean section were recorded. The indications for the second cesarean section were analyzed. The gestational weeks at delivery, blood loss in 2 hours after delivery, neonatal birth weight, newborn asphyxia, the rate of postpartum fever (≥ 38 °C) and hospitalization days were compared between the two approaches of delivery. (1) Among the 178 cases, 119 cases attempted vaginal labor, the rate of attempting vaginal labor was 66.9% (119/178). A total of 113 cases succeeded in vaginal delivery (the vaginal delivery group), with the successful rate of attempting vaginal delivery of 95.0% (113/119), and the successful rate of vaginal delivery was 63.5% (113/178). For those 119 women succeeded in vaginal delivery, the indications of the previous cesarean sections were as following: pregnancy complications (68.1%, 81/119), macrosomia(5.0%, 6/119), dystocia (14.3%, 17/119), pregnancies complicated with other diseases (5.0%, 6/119) and cesarean section on maternal request (7.6%, 9/119). (2) 15 cases in the cesarean section group had postpartum hemorrhage, with the incidence of 13.3% (15/113). The mean total labor time was (507 ± 182) minutes. 6 cases attempting vaginal delivery failed and turned to cesarean section. (3) 59 cases received the second cesarean section (the cesarean section group). The rate of second cesarean section was 33.1% (59/178). The indications of the second cesarean section were as following: contracted pelvis (5%, 3

  14. Additional coiling of previously coiled cerebral aneurysms : Clinical and angiographic results

    NARCIS (Netherlands)

    Slob, MJ; Sluzewski, M; van Rooij, WJ; Roks, G; Rinkel, GJE

    BACKGROUND AND PURPOSE: Some cerebral aneurysms that have been coiled reopen over time and additional treatment should be considered to reduce the risk of recurrent hemorrhage. Our purpose was to assess procedural complications and angiographic results of additional coiling in patients with

  15. Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.

    Science.gov (United States)

    van Greunen, Divan G; Cordier, Werner; Nell, Margo; van der Westhuyzen, Chris; Steenkamp, Vanessa; Panayides, Jenny-Lee; Riley, Darren L

    2017-02-15

    A series of twenty seven acetylcholinesterase inhibitors, as potential agents for the treatment of Alzheimer's disease, were designed and synthesised based upon previously unexplored chemical space surrounding the molecular skeleton of the drug donepezil, which is currently used for the management of mild to severe Alzheimer's disease. Two series of analogues were prepared, the first looking at the replacement of the piperidine ring in donepezil with different sized saturated N-containing ring systems and the second looking at the introduction of different linkers between the indanone and piperidine rings in donepezil. The most active analogue 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl 1-benzylpiperidine-4-carboxylate (67) afforded an in vitro IC 50 value of 0.03 ± 0.07 μM against acetylcholinesterase with no cytotoxicity observed (IC 50 of >100 μM, SH-SY5Y cell line). In comparison donepezil had an IC 50 of 0.05 ± 0.06 μM and an observed cytotoxicity IC 50 of 15.54 ± 1.12 μM. Molecular modelling showed a strong correlation between activity and in silico binding in the active site of acetylcholinesterase. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  16. Potential substitution of ammonium chloride in Ruhr coal hydrogenation. (Previous test results)

    Energy Technology Data Exchange (ETDEWEB)

    Grassl

    1943-10-20

    The report related that ammonium chloride could be nearly totally replaced by equivalent amounts of elemental chlorine in the form of gas, chlorinated grinding oil, moderately chlorinated coal, as well as hydrogen chloride. Similar results were obtained using organic chloride compounds, such as carbon tetrachloride. Sulfur monochloride was also considered a substitute for ammonium chloride, since sulfuric acid and ammonium fluoride were considered unfavorable at the time. At a reaction temperature 1/2 mV higher than usual, phosphoric acid gave results similar to those of ammonium chloride except for splitting. By using metal powders (Fe, Al, Zn, Sn, etc.), the amount of chlorine could be reduced from 1/3 to 1/2, yet to attain a favorable reduction in asphalt as with NH/sub 4/Cl, a slight temperature increase was necessary. Tests with chlorine-containing water-soluble aluminum oxide as well as aqueous aluminum chloride appeared to be good prospects and were to be followed up. A number of summaries were referred to in relation to this report.

  17. An investigation of false positive dosimetry results

    International Nuclear Information System (INIS)

    Lewandowski, M.A.; Davis, S.A.; Goff, T.E.; Wu, C.F.

    1996-01-01

    The Waste Isolation Pilot Plant (WIPP) is a facility designed for the demonstration of the safe disposal of transuranic waste. Currently, the radiation source term is confined to sealed calibration and check sources since WIPP has not received waste for disposal. For several years the WIPP Dosimetry Group has operated a Harshaw Model 8800C reader to analyze Harshaw 8801-7776 thermoluminescent cards (3 TLD-700 and 1 TLD-600) with 8805 holder. The frequency of false positive results for quarterly dosimeter exchanges is higher than desired by the Dosimetry Group management. Initial observations suggested that exposure to intense ambient sunlight may be responsible for the majority of the false positive readings for element 3. A study was designed to investigate the possibility of light leaking through the holder and inducing a signal in element 3. This paper discusses the methods and results obtained, with special emphasis placed on recommendations to reduce the frequency of light-induced false positive readings

  18. Results of LIA-10M accelerator investigations

    CERN Document Server

    Gordeev, V S; Filippov, V O

    2001-01-01

    There are presented basic results of experiments on the LIA-10M accelerator since its putting into operation (1994) till today. There were investigated various modes of accelerator operation and its output characteristics depending on the parameters of injected electron beam,number of connected accelerator modules,time program of inductors switch-in etc. There was obtained a large scope of experimental data that are of interest for LIA-10M accelerator practical use and for the development of new facilities of this type. The investigations that have been performed recently make it possible to considerably (half as much again) increase the output dose parameters of the accelerator as compared to the level achieved before:maximal dose(Si) and dose rate on the output flange constitute 400 Gy and 2.5 centre dot 10 Gy/s, while at a 1 meter distance from the target they are equal to 7.5 Gy and 5 centre dot 10 sup 8 Gy/s, respectively.

  19. Archaeogeophysical investigations in Tiwanaku: preliminary results

    Science.gov (United States)

    Masini, Nicola; Sileo, Maria; Lasaponara, Rosa; Leucci, Giovanni; Orefici, Giuseppe; Rizzo, Enzo

    2017-04-01

    -1450) Tiwanaku was characterized by the resurgence of regional identities and polities In spite of the rich archaeological record numerous issues, related to the function and the extension of Tiwanaku, need to be investigated especially in the monumental core which includes the pyramid of Akapana, and other ceremonial places such Kalasasaya, Putuni and Kantatallita. To this aims some geophysical investigations were performed in 2009 and 2014 in the context of multidisciplinary research including the use of satellite remote sensing [8]. This paper deals with the discussion of preliminary results of geomagnetic and GPR investigations, some of which have been verified by trial archaeological excavations which have unearthed some buried structures, improving the knowledge of the ceremonial areas of Tiwanaku. References [1] Lasaponara R., Leucci G., Masini N., Persico R., Scardozzi G., Towards an operative use of remote sensing for exploring the past using satellite data: The case study of Hierapolis (Turkey), Remote sensing of Environment, 174 (2016) : 148-164, doi:10.1016/j.rse.2015.12.016 [2] Masini N., Lasaponara R., Rizzo E., Orefici G. 2012. Integrated Remote Sensing Approach in Cahuachi (Peru): Studies and Results of the ITACA Mission (2007-2010), In: Lasaponara R., Masini N. (Eds) 2012, Satellite Remote Sensing: a new tool for Archaeology, Springer, Verlag Berlin Heidelberg, ISBN 978-90-481-8800-0, doi: 10.1007/978-90-481-8801-7_14; pp. 307-344 [3] Rizzo E., Masini N., Lasaponara R., Orefici G. 2010, ArchaeoGeophysical methods in the Templo del Escalonado (Cahuachi, Nasca, Perù), Near Surface Geophysics 8 (5), 433-439, doi:10.3997/1873-0604.2010030 [4] Masini N., Rizzo E., Lasaponara R., and Orefici G. 2008, Integrated remote sensing techniques for the detection of buried archaeological adobe structures: preliminary results in Cahuachi (Peru), Advances in Geosciences, 19, 75-82 [5] Lasaponara R., Leucci G., Masini N., Persico R. 2014. Investigating archaeological looting

  20. Investigations of auroral dynamics: techniques and results

    International Nuclear Information System (INIS)

    Steen, Aa.

    1988-10-01

    This study is an experimental investigation of the dynamics of the aurora, describing both the systems developed for the optical measurements and the results obtained. It is found that during a auroral arc deformation, a fold travelling eastward along the arc is associated with an enhanced F-region ion temperature of 2700 K, measured by EISCAT, indicative of enhanced ionspheric electric fields. It is shown that for an auroral break-up, the large-scale westward travelling surge (WTS) is the last developed spiral in a sequence of spiral formations. It is proposed that the Kelvin-Helmholtz instability is the responsible process. In another event it is shown that large-amplitude long-lasting pulsations, observed both in ground-based magnetic field and photometer recordings, correspond to strong modulations of the particle intensity at the equatorial orbit (6.6 Re). In this event a gradual transition occurs between pulses classified as Ps6/auroral torches toward pulses with characteristics of substorms. The observations are explained by the Kelvin-Helmholtz instability in a magnetospheric boundary layer. The meridional neutral wind, at about 240 km altitude, is found to be reduced prior to or at the onset of auroral activity. These findings are suggestive of large-scale reconfigurations of the ionspheric electric fields prior to auroral onsets. A new real time triangulation technique developed to determine the altitude of auroral arcs is presented, and an alternative method to analyze incoherent scatter data is discussed. (With 46 refs.) (author)

  1. Deciding on the mode of birth after a previous caesarean section - An online survey investigating women's preferences in Western Switzerland.

    Science.gov (United States)

    Bonzon, Magali; Gross, Mechthild M; Karch, André; Grylka-Baeschlin, Susanne

    2017-07-01

    promoting vaginal births after caesarean section (VBAC) for eligible women and increasing rates of successful VBACs are the best strategies to reduce the number of repeat caesarean sections (CS). Knowledge of factors that are associated with women's decision-making around mode of birth after CS is important when developing strategies to promote VBAC. This study assessed which factors are associated with women's preferences for VBAC versus elective repeat caesarean section (ERCS) in a new pregnancy after one previous caesarean in Switzerland. cross-sectional web-survey. Western Switzerland. French-speaking women living in Western Switzerland, with one previous CS who gave birth subsequently to a child after a complication-free pregnancy were eligible to participate in the survey. Of 393 women who started the survey in November/December 2014, 349 were included: 227 who planned a VBAC and 122 who planned an ERCS at term. univariable and multivariable analyses were conducted to describe and compare women who had planned a VBAC with women who had planned an ERCS in a pregnancy following a CS. Logistic regression modelling was used to investigate predictors that were associated with a preference for a VBAC at term. Analyses were performed with SPSS 22 and Stata 13. of the women planning a VBAC, 62.6% VBAC gave birth vaginally. Predictors which were significantly associated with increased odds of women choosing a VBAC: duration since previous birth in years (OR=1.11 95% CI [1.03-1.20], p=0.010), having had midwifery care during pregnancy (OR=2.09, 95% CI [1.08-4.05], p=0.029), being advised by their healthcare provider to attempt a VBAC (OR=4.20, 95% CI [1.75-10.09], p=0.001), preference for VBAC during the third trimester of their pregnancy (OR=3.98, 95% CI [1.77-8.93], p=0.001), and wishing to let the child choose the moment of birth (OR=1.46, 95% CI[1.22-1.74], p<0.001). The importance of safety for the mother decreased the odds of women preferring a VBAC (OR=0.74, 95

  2. Continuation of the summarizing interim report on previous results of the Gorleben site survey as of May 1983

    International Nuclear Information System (INIS)

    1990-04-01

    In addition to results from the 1983 interim report, this report contains, in order to supplement the surface explorations, seismic reflection measurements, hydrogeologic and seismologic investigations, sorption experiments, and studies of glacial development in the site region and of long-term safety of final waste repositories in salt domes. The site's high grade of suitability for becoming a final radioactive waste repository, the legal basis as well as quality assurance are evaluated. (orig.) [de

  3. COMPARISON OF THE RESULTS OF BLOOD GLUCOSE SELFMONITORING AND CONTINUOUS GLUCOSE MONITORING IN PREGNANT WOMEN WITH PREVIOUS DIABETES MELLITUS

    Directory of Open Access Journals (Sweden)

    A. V. Dreval'

    2015-01-01

    Full Text Available Background: Pregnancy is one of the indications for continuous glucose monitoring (CGM. The data on its efficiency in pregnant women are contradictory.Aim: To compare the results of blood glucose self-monitoring (SMBG and CGM in pregnant women with previous diabetes mellitus.Materials and methods: We performed a cross-sectional comparative study of glycemia in 18 pregnant women with previous type 1 (87.8% of patients and type 2 diabetes (22.2% of patients with various degrees of glycemic control. Their age was 27.7 ± 4.9 year. At study entry, the patients were at 17.2 ± 6.1 weeks of gestation. CGM and SMBG were performed in and by all patients for the duration of 5.4 ± 1.5 days. Depending on their HbA1c levels, all patients were divided into two groups: group 1 – 12 women with the HbA1c above the target (8.5 ± 1%, and group 2 – 6 women with the HbA1c levels within the target (5.6 ± 0.3%.Results: According to SMBG results, women from group 2 had above-the-target glycemia levels before breakfast, at 1 hour after breakfast and at bedtime: 6.2 ± 1.6, 8.7 ± 2.1, and 5.7 ± 1.9 mmol/L, respectively. According to CGM, patients from group 1 had higher postprandial glycemia than those from group 2 (8.0 ± 2.1 and 6.9 ± 1.8 mmol/L, respectively, p = 0.03. The analysis of glycemia during the day time revealed significant difference between the groups only at 1 hour after dinner (7.1 ± 1.4 mmol/L in group 1 and 5.8 ± 0.9 mmol/L in group 2, р = 0.041 and the difference was close to significant before lunch (6.0 ± 2.2 mmol/L in group 1 and 4.8 ± 1.0 mmol/L in group 2, р = 0.053. Comparison of SMBG and CGM results demonstrated significant difference only at one timepoint (at 1 hour after lunch and only in group 1: median glycemia was 7.4 [6.9; 8.1] mmol/L by SMBG and 6 [5.4; 6.6] mmol/L by CGM measurement (р = 0.001. Lower median values by CGM measurement could be explained by averaging of three successive measurements carried out in the

  4. Preliminary results of the first paleontologic investigations in Uruguayan Antarctica

    International Nuclear Information System (INIS)

    Perea, D.; Masquelin, E.; Verde, M.; Querequiz, R.

    1998-01-01

    Preliminary results of the first Uruguayan paleontollogic and biostratigraphical investigations in Antartica are presented. The field work was performed in fildes Peninsula, King George Island, near Uruguayan station Base Cientifica Antarctica Artigas.Some fossiliferous outcrops were geologic and paleontologically analyzed, among them Fossil Hills, situated in the center part of the peninsula, in front of Ardley Island, between the chinese and chilean stations.This hill is composed of fossil bearing piroclastic and epiclastic rocks, assigned to the fossil Hill Fm. Vegetal remains(petrified wood and leaf impronts) were observed and collected in this unit and it is remarkable the presence of Nothofagus sp. and invertebrate trace fossils, Cochlichmus isp and Helminthopsis isp.The depositional environment deduced from the fossil association in lacustrine, under a warm and humid climate.In the same deposits, other investigators have collected aquatic and ratite bird trace fossils. Paleontologic evidence is not contradictory with the Eocene age previously proposed for the studied deposits. (author)

  5. Investigating physiological methods to determine previous exposure of immature insects to ionizing radiation and estimating the exposure dose

    International Nuclear Information System (INIS)

    Mansour, M.

    1999-01-01

    Effects of gamma radiation on pupation and adult emergence in mature (diapausing and non-diapausing) codling moth, Cydia pomonella L., larvae and on phenoloxidase activity in larvae killed by freezing were investigated. Results showed that, a dose of 50 Gy reduced adult emergence (and pupation) significantly and a dose of 200 Gy completely prevented it. Diapausing larvae were more susceptible to irradiation than non-diapausing larvae, and female moths were more susceptible to irradiation injury than males. Phenoloxidase activity in codling moth larvae was determined spectrophotometrically by measuring the increase in optical density at 490 nm, or by observing the degree of melanization in larvae killed by freezing. Results showed that, in un-irradiated larvae, phenoloxidase activity can be detected in 7 days old larvae and it continues to accumulate throughout the larvae stage. This accumulation was not observed when larvae were irradiated with a minimum dose of 50 Gy during the 1st week of their development. However, irradiating larvae in which enzyme activity was already high (2-3 week old) did not remove activity but only reduced further accumulation. Larval melanization studies were in agreement with results of the phenoloxidase assay.(author)

  6. Investigating physiological methods to determine previous exposure of immature insects to ionizing radiation and estimating the exposure dose

    International Nuclear Information System (INIS)

    Mansour, M.

    1998-10-01

    Effects of gamma radiation on pupation and adult emergence in mature (diapausing and non-diapausing) codling moth, Cydia pomonella L., larvae and on phenoloxidase activity in larvae killed by freezing were investigated. Results showed that, a dose of 50 Gy reduced adult emergence (and pupation) significantly and 200 Gy completely prevented it. Diapausing larvae were more susceptible to irradiation that non-diapausing larvae and female moths were more susceptible to irradiation injury than males. Phenoloxidase activity in codling moth larvae was determined spectrophotometrically by measuring the increase in optical density at 490 nm, or by observing the degree of melanization in larvae killed by freezing. Results showed that, in un-irradiated larvae, phenoloxidase activity can be detected in 7 day old larvae and activity continued to accumulate throughout the larval stage. This accumulation was not observed when larvae were irradiated with a minimum dose of 50 Gy during the 1st week of their development. However, irradiating larvae in which enzyme activity was already high (2-3 week old) did not remove activity but only reduced further accumulation. Larval melanization studies were in agreement with results of the phenoloxidase assay. (author)

  7. Overview of JET post-mortem results following the 2007-9 operational period, and comparisons with previous campaigns

    Science.gov (United States)

    Coad, J. P.; Gruenhagen, S.; Hole, D. E.; Hakola, A.; Koivuranta, S.; Likonen, J.; Rubel, M.; Widdowson, A.; contributors, JET-EFDA

    2011-12-01

    In 2010, all the plasma-facing components were removed from JET so that the carbon-based surfaces could be replaced with beryllium (Be) or tungsten as part of the ITER-like wall (ILW) project. This gives unprecedented opportunities for post-mortem analyses of these plasma-facing surfaces; this paper reviews the data obtained so far and relates the information to studies of tiles removed during previous JET shutdowns. The general pattern of erosion/deposition at the JET divertor has been maintained, with deposition of impurities in the scrape-off layer (SOL) at the inner divertor and preferential removal of carbon and transport into the corner. However, the remaining films in the SOL contain very high Be/C ratios at the surface. The first measurements of erosion using a tile profiler have been completed, with up to 200 microns erosion being recorded at points on the inner wall guard limiters.

  8. Investigating of the Knocking Out Properties of Moulding Sands with New Inorganic Binders Used for Castings of Non-ferrous Metal Alloys in Comparison with the Previously Used

    Directory of Open Access Journals (Sweden)

    I. Izdebska-Szanda

    2012-12-01

    Full Text Available The article presents the results of investigations, which make a fragment of the broad-scale studies carried out as a part of the projectPOIG.01.01.02-00-015/09 “Advanced materials and technologies”.One of the objectives of the introduction of new inorganic binders is to provide a good knocking out properties of moulding sands, whilemaintaining an appropriate level of strength properties.Therefore, a logical continuation of the previous studies were carried out the tests knocking out properties of moulding sands with newinorganic binders, including making moulds, pouring them by the chosen of non-ferrous metal alloys, knoking-out, and determining theknocking out work.The results of the study were related to the research results obtained by applying the moulding sand performed by existing technology.

  9. Effects of 60 Hz electromagnetic fields on early growth in three plant species and a replication of previous results

    Energy Technology Data Exchange (ETDEWEB)

    Davis, M.S. [Univ. of Sunderland (United Kingdom). Ecology Centre

    1996-05-01

    In an attempt to replicate the findings of Smith et al., seeds of Raphanus sativus L. (radish), Sinapsis alba L. (mustard), and Hordeum vulgare L. (barley) were grown for between 9 and 21 days in continuous electromagnetic fields (EMFs) at ion-cyclotron resonance conditions for stimulation of Ca{sup 2+} (B{sub H} = 78.3 {micro}T, B{sub HAC} = 40 {micro}T peak-peak at 60 Hz, B{sub v} = 0). On harvesting, radish showed results similar to those of Smith et al. Dry stem weight and plant height were both significantly greater (Mann-Whitney tests, Ps < 0.05) in EMF-exposed plants than in control plants in each EMF experiment. Wet root weight was significantly greater in EMF-exposed plants in two out of three experiments, as were dry leaf weight, dry whole weight, and stem diameter. Dry root weight, wet leaf weight, and wet whole weight were significantly greater in EMF-exposed plants in one of three experiments. All significant differences indicated an increase in weight or size in the EMF-exposed plants. In each of the sham experiments, no differences between exposed and control plants were evident. Mustard plants failed to respond to the EMFs in any of the plant parameters measured. In one experiment, barley similarly failed to respond; but in another showed significantly greater wet root weight and significantly smaller stem diameter and dry seed weight at the end of the experiment in exposed plants compared to control plants. Although these results give no clue about the underlying bioelectromagnetic mechanism, they demonstrate that, at least for one EMF-sensitive biosystem, results can be independently replicated in another laboratory. Such replication is crucial in establishing the validity of bioelectromagnetic science.

  10. Effects of 60 Hz electromagnetic fields on early growth in three plant species and a replication of previous results.

    Science.gov (United States)

    Davies, M S

    1996-01-01

    In an attempt to replicate the findings of Smith et al., seeds of Raphanus sativus L. (radish), Sinapsis alba L. (mustard), and Hordeum vulgare L. (barley) were grown for between 9 and 21 days in continuous electromagnetic fields (EMFs) at "ion-cyclotron resonance" conditions for stimulation of Ca(2+) (B(H) = 78.3 mu T, B(HAC) = 40 mu T peak-peak at 60 Hz, B(V) = 0). On harvesting, radish showed results similar to those of Smith et al. Dry stem weight and plant height were both significantly greater (Mann-Whitney tests, Ps < 0.05) in EMF-exposed plants than in control plants in each EMF experiment. Wet root weight was significantly greater in EMF-exposed plants in two out of three experiments, as were dry leaf weight, dry whole weight, and stem diameter. Dry root weight, wet leaf weight, and wet whole weight were significantly greater in EMF-exposed plants in one of three experiments. All significant differences indicated an increase in weight or size in the EMF-exposed plants. In each of the sham experiments, no differences between exposed and control plants were evident. Mustard plants failed to respond to the EMFs in any of the plant parameters measured. In one experiment, barley similarly failed to respond; but in another showed significantly greater wet root weight and significantly smaller stem diameter and dry seed weight at the end of the experiment in exposed plants compared to control plants. Although these results give no clue about the underlying bioelectromagnetic mechanism, they demonstrate that, at least for one EMF-sensitive biosystem, results can be independently replicated in another laboratory. Such replication is crucial in establishing the validity of bioelectromagnetic science.

  11. Locating previously unknown patterns in data-mining results: a dual data- and knowledge-mining method

    Directory of Open Access Journals (Sweden)

    Knaus William A

    2006-03-01

    Full Text Available Abstract Background Data mining can be utilized to automate analysis of substantial amounts of data produced in many organizations. However, data mining produces large numbers of rules and patterns, many of which are not useful. Existing methods for pruning uninteresting patterns have only begun to automate the knowledge acquisition step (which is required for subjective measures of interestingness, hence leaving a serious bottleneck. In this paper we propose a method for automatically acquiring knowledge to shorten the pattern list by locating the novel and interesting ones. Methods The dual-mining method is based on automatically comparing the strength of patterns mined from a database with the strength of equivalent patterns mined from a relevant knowledgebase. When these two estimates of pattern strength do not match, a high "surprise score" is assigned to the pattern, identifying the pattern as potentially interesting. The surprise score captures the degree of novelty or interestingness of the mined pattern. In addition, we show how to compute p values for each surprise score, thus filtering out noise and attaching statistical significance. Results We have implemented the dual-mining method using scripts written in Perl and R. We applied the method to a large patient database and a biomedical literature citation knowledgebase. The system estimated association scores for 50,000 patterns, composed of disease entities and lab results, by querying the database and the knowledgebase. It then computed the surprise scores by comparing the pairs of association scores. Finally, the system estimated statistical significance of the scores. Conclusion The dual-mining method eliminates more than 90% of patterns with strong associations, thus identifying them as uninteresting. We found that the pruning of patterns using the surprise score matched the biomedical evidence in the 100 cases that were examined by hand. The method automates the acquisition of

  12. Sudden onset of cauda equina syndrome resulting from posterior migration of lumbar herniated disc without significant previous neurological signs.

    Science.gov (United States)

    Ju, Jeong-Hyuk; Kim, Hyun-Woo; Jung, Chul-Ku; Ha, Ho-Gyun

    2012-09-01

    While extruded disc fragments are known to migrate anteriorly, posteriorly, or laterally to the theca sac, posterior migration of the fragments is relatively rare and sudden onset of cauda equina syndrome (CES) caused by the migration is extremely rare. The authors experienced a case of CES that was manifested abruptly with sudden paraplegia caused by posterior migration of the lumbar intervertebral disc. A 74-year old man, who had no prior significant neurologic signs or trauma history, visited our emergency center with paraplegia of both lower extremities occurring suddenly when awakened. On magnetic resonance image (MRI) findings, we could detect ruptured disc herniation with severe lumbar stenosis at the L2-3 level. We performed an emergent decompression, and the right posterior migrated disc fragments at L2-3 were intraoperatively observed. The patient was fully recovered himself on the follow up after 3 months of the operation. In conclusion, early operation can result in better outcome in acute paraplegia caused by the posterior migrated disc fragments.

  13. Making the best use of our previous results as a clue for interpreting kinetics of scintigraphic agents

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Sato

    2011-08-01

    Full Text Available Up to now, we have performed scintigraphy with 201-thallium chloride (201-TlCl and 99m-Tc-hexakis-2-methoxy-isobutyl-isonitrile (99m-Tc-MIBI for malignant tumors and lymphoscintigraphy with 99m-Tc-rhenium-colloid (99m-Tc-Re and 99m-Tc-human-serum-albumin-diethylene-triamine-penta-acetic-acid (99m-Tc-HSA-D for lymph node metastasis. In this article, we re-evaluated scintigraphic images retrospectively with a hope that the results might be a clue, even if it is small, for dentists to try to improve the accuracy of diagnosis of malignant tumors. From scintigraphy, we obtained the tumor retention index as a factor to estimate the uptake of radioactive agents in tumor cells. Moreover, we estimated transport proteins of Na+/K+-ATPase and permeability-glycoprotein (P-gp expressed on the cell membrane that might regulate the kinetic condition of radioactive agents. Among the tumor retention index, the transport protein and the histopathologic finding of tumors, there were relatively well correlations. The tumor retention index showed a difference clearly between malignant tumor and benign tumor. The transport protein revealed a distinct expression in accordance with the malignancy of tumor, and the uptake clearly depended upon the expression of transport protein. Moreover, the lymph node metastasis was detected well by lymphoscintigraphy with 99m-Tc-Re and 99m-Tc-HSA-D.

  14. Volatile Organic Compound Investigation Results, 300 Area, Hanford Site, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Robert E.; Williams, Bruce A.; Smith, Ronald M.

    2008-07-07

    Unexpectedly high concentrations of volatile organic compounds (VOC) were discovered while drilling in the unconfined aquifer beneath the Hanford Site’s 300 Area during 2006. The discovery involved an interval of relatively finer-grained sediment within the unconfined aquifer, an interval that is not sampled by routine groundwater monitoring. Although VOC contamination in the unconfined aquifer has been identified and monitored, the concentrations of newly discovered contamination are much higher than encountered previously, with some new results significantly higher than the drinking water standards. The primary contaminant is trichloroethene, with lesser amounts of tetrachloroethene. Both chemicals were used extensively as degreasing agents during the fuels fabrication process. A biological degradation product of these chemicals, 1,2-dichloroethene, was also detected. To further define the nature and extent of this contamination, additional characterization drilling was undertaken during 2007. Four locations were drilled to supplement the information obtained at four locations drilled during the earlier investigation in 2006. The results of the combined drilling indicate that the newly discovered contamination is limited to a relatively finer-grained interval of Ringold Formation sediment within the unconfined aquifer. The extent of this contamination appears to be the area immediately east and south of the former South Process Pond. Samples collected from the finer-grained sediment at locations along the shoreline confirm the presence of the contamination near the groundwater/river interface. Contamination was not detected in river water that flows over the area where the river channel potentially incises the finer-grained interval of aquifer sediment. The source for this contamination is not readily apparent. A search of historical documents and the Hanford Waste Information Data System did not provide definitive clues as to waste disposal operations and

  15. New results of investigations of whistler-mode chorus emissions

    Directory of Open Access Journals (Sweden)

    O. Santolík

    2008-07-01

    Full Text Available This review summarizes selected recent results obtained during investigation of whistler-mode chorus emissions in the Earth's magnetosphere. Special attention is paid to results published during the last five years, with a focus on the results of the CLUSTER project. The nonlinear nature of chorus emissions is demonstrated using both theoretical results and measurements. Selected areas of research on whistler-mode chorus are covered and the paper especially reports new results on substructure and amplitudes of chorus wave packets, on new observations of frequency differences of chorus wave packets at different points in space and on their possible interpretations, on results concerning determination of position and size of the source region of chorus, on recent observational and theoretical results which lead to improved description of propagation of chorus from its source, and, finally, on comparison of chorus measurements with corresponding values deduced from nonlinear theory and simulations.

  16. Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trial.

    Science.gov (United States)

    Coppens, Michiel; Synhorst, David; Eikelboom, John W; Yusuf, Salim; Shestakovska, Olga; Connolly, Stuart J

    2014-07-21

    The AVERROES double-blinded, randomized trial demonstrated that apixaban reduces the risk of stroke or systemic embolism (SSE) by 55% compared with aspirin without an increase in major bleeding in patients with atrial fibrillation either who previously tried but failed vitamin K antagonists (VKA) therapy or who were expected to be unsuitable for VKA therapy. In this pre-specified analysis, we explored the consistency of the results in the subgroup of patients who tried but failed VKA therapy. Of 5599 patients, 2216 (40%) had previously failed VKA treatment [main reasons: poor international normalized ratio (INR) control 42%, refusal 37%, bleeding on VKA 8%]. Compared with those expected to be unsuitable for VKA therapy, those who had previously failed were older, more often male, had higher body mass index, more likely to have moderate renal impairment and a history of stroke and less likely to have heart failure or to be medically undertreated. The effects of apixaban compared with aspirin were consistent in those who previously failed and those who were expected to be unsuitable, for both SSE (P interaction 0.13) and major bleeding (P interaction 0.74) and were also consistent among different subgroups of patients who had previously failed VKA therapy defined by reasons for unsuitability, age, sex, renal function, CHADS2 score, aspirin dose, duration, indication, and quality of INR control of prior VKA use. The efficacy and safety of apixaban compared with aspirin is consistent in subgroups of patients who have previously attempted but failed VKA therapy, irrespective of the reason for discontinuation. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.

  17. Investigation for Ensuring the Reliability of the MELCOR Analysis Results

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Joonyoung; Maeng, Yunhwan; Lee, Jaeyoung [Handong Global Univ., Pohang (Korea, Republic of)

    2015-10-15

    Flow rate could be also main factor to be proven because it is in charge of a role which takes thermal balance through heat transfer in inner side of fuel assembly. Some problems about a reliability of MELCOR results could be posed in the 2{sup nd} technical report of NSRC project. In order to confirm whether MELCOR results are dependable, experimental data of Sandia Fuel Project 1 phase were used to be compared to be a reference. In Spent Fuel Pool (SFP) severe accident, especially in case of boil-off, partial loss of coolant accident, and complete loss of coolant accident; heat source and flow rate could be main points to analyze the MELCOR results. Heat source might be composed as decay heat and oxidation heat. Because heat source makes it possible to lead a zirconium fire situation if it is satisfied that heat accumulates in spent fuel rod and then cladding temperature could be raised continuously to be generated an oxidation heat, this might be a main factor to be confirmed. This work was proposed to investigate reliability of MELCOR results in order to confirm physical phenomena if SFP severe accident is occurred. Almost results showed that MELCOR results were significantly different by minute change of main parameter in identical condition. Therefore it could be necessary that oxidation coefficients have to be chosen as value to delineate real phenomena as possible.

  18. Solar thermally driven cooling systems: Some investigation results and perspectives

    International Nuclear Information System (INIS)

    Ajib, Salman; Günther, Wolfgang

    2013-01-01

    over the surfaces of heat exchangers more effective. Thus, many investigations have been done on some types of heat exchangers for optimization of heat and mass transfer in the system. In this contribution we will show some investigation results on solar thermally driven system in small capacity range. Moreover, we will illustrate an experimental setup for investigation of heat transfer by shell tube heat exchanger consisting of two kinds of tubes. The first one has a smooth outer surface and the other one has a ribbed outer surface. The aim of these investigations is to optimize the whole system.

  19. Results of EPRI/ANL DCH investigations and model development

    International Nuclear Information System (INIS)

    Spencer, B.W.; Sienicki, J.J.; Sehgal, B.R.; Merilo, M.

    1988-01-01

    The results of a series of five experiments are described addressing the severity and mitigation of direct containment heating. The tests were performed in a 1:30 linear scale mockup of the Zion PWR containment system using a reactor-material corium melt consisting of 60% UO 2 , 16% ZrO 2 , 24% SSt at nominally 2800C initial temperature. A ''worst-case'' type test involving unimpeded corium dispersal through an air atmosphere in a closed vessel produced an atmosphere heatup of 323K, equivalent to a DCH efficiency of 62%. With the addition of structural features which impeded the corium dispersal, representative of dispersal pathway features at Zion, the DCH efficiency was reduced to 1--5%. (This important result is scale dependent and requires larger scale tests such as the SURTSEY program at SNL plus mechanistic modeling for application to the reactor system.) With the addition of water in the cavity region, there was no measurable heatup of the atmosphere. This was attributable to the vigorous codispersal of water with corium which prevented the temperature of the atmosphere from significantly exceeding T/sub sat/. In this case the DCH load was replaced by the more benign ''steam spike'' from corium quench. Significant oxidation of the corium constituents occurred in the tests, adding chemical energy to the system and producing hydrogen. Overall, the results suggest that with consideration of realistic, plant specific, mitigating features, DCH may be no worse and possibly far less severe than the previously examined steam spike. Implications for accident management are addressed. 17 refs., 7 figs., 4 tabs

  20. Coupled Interpretation of Geoelectrical Surveying Results in Environmental Site Investigations

    Science.gov (United States)

    Skold, M.; Hubbard, S. S.; Karaoulis, M.; Revil, A.; Spycher, N.; Watson, D. B.; Wu, Y.

    2011-12-01

    Geoelectric methods are sensitive to material properties which can be used to investigate subsurficial processes at contaminated sites. Electrical resistivity tomography (ERT) measures the electrical resistivity distribution in the ground; the self-potential (SP) method is based on source current densities resulting from ground water flow; and induced polarization (IP) responds to geochemical interactions between mineral surfaces and pore fluids. Ground water flow patterns and contaminant migration may be better understood if the results of these survey methods are interpreted jointly rather than separately. The purpose of this project is to jointly interpret results of geophysical surveying and laboratory characterization of soil and ground water samples to assess ground water flow patterns and contaminant migration at a site within the Oak Ridge National Laboratory. Historical disposal of liquid waste containing nitric acid and uranium in unlined ponds has resulted in contamination of soil and ground water. ERT, SP, and IP surveying was performed downgradient of the source area and the geophysical behavior of sediment and ground water samples was investigated in the laboratory. Measured electrical conductivity and self-potential anomalies coincided with elevated nitrate and uranium concentrations indicating preferential flow from the source area. The self-potential response can be related to ground water flow either by calculating the excess of charge in the diffuse layer surrounding mineral surfaces or by the streaming potential coupling coefficient. Geochemical reactions between pore water and minerals and their surfaces were modeled using the contaminant transport software TOUGHREACT. Surface complexation modeling using the Gouy-Chapman diffuse double layer was used to simulate charge density-surface potential relationship. Laboratory measurements of the streaming potential coupling coefficient of sediment samples at various pH and salt concentrations were

  1. Risk for high depressive symptoms in diagnosed and previously undetected diabetes: 5-year follow-up results of the Heinz Nixdorf Recall study.

    Directory of Open Access Journals (Sweden)

    Andrea Icks

    Full Text Available OBJECTIVE: The objective of this study was to determine the risk for the development of high depressive symptoms in study participants with diagnosed and previously undetected diabetes mellitus compared to those without diabetes in a prospective population-based cohort study in Germany. METHODS: We estimated the 5-year cumulative incidence of high depressive symptoms in participants without high depressive symptoms at baseline (n = 3,633, 51.4% men, mean age (SD 59.1 (7.6 years, 7.0% diagnosed diabetes, 5.3% previously undetected diabetes from the population-based Heinz Nixdorf Recall study. Diabetes was assessed by self-report, medication, and blood glucose. High depressive symptoms were assessed using CES-D. We calculated odds ratios and their corresponding 95% confidence interval, using multiple logistic regression analyses. RESULT: Cumulative 5-year incidences (95% CI of high depressive symptoms in participants with diagnosed, undetected, and without diabetes were 7.1 (4.2-10.9, 4.1 (1.8-8.0, and 6.5 (5.6-7.4, respectively. The age-sex-adjusted OR for developing high depressive symptoms was 1.22 (0.74-2.03 in participants with diagnosed compared to those without diabetes, and 1.00 (0.59-1.68 after adjustment for BMI, physical activity, education, stroke, and myocardial infarction. The age-sex adjusted OR for developing high depressive symptoms in participants with previously undetected diabetes compared to those without diabetes was 0.72; 0.35-1.48; and fully adjusted 0.62; 0.30-1.30. CONCLUSION: We found no significant associations, maybe due to low power. However, our results are in line with a recent meta-analysis suggesting that risk of developing high depressive symptoms in patients with diagnosed diabetes may be moderately higher than in those without diabetes, and that comorbidity may explain in part this association. In participants with previously undetected diabetes, this first longitudinal study indicates that the risk is not

  2. Mobile phone messaging for communicating results of medical investigations.

    Science.gov (United States)

    Gurol-Urganci, Ipek; de Jongh, Thyra; Vodopivec-Jamsek, Vlasta; Car, Josip; Atun, Rifat

    2012-06-13

    Mobile phone messaging, such as Short Message Service (SMS) and Multimedia Message Service (MMS), has rapidly grown into a mode of communication with a wide range of applications, including communicating the results from medical investigations to patients. Alternative modes of communication of results include face-to-face communication, postal messages, calls to landlines or mobile phones, through web-based health records and email. Possible advantages of mobile phone messaging include convenience to both patients and healthcare providers, reduced waiting times for health services and healthcare costs. To assess the effects of mobile phone messaging for communicating results of medical investigations, on people's healthcare-seeking behaviour and health outcomes. Secondary objectives include assessment of participants' evaluation of the intervention, direct and indirect healthcare costs and possible risks and harms associated with the intervention. We searched the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2009, Issue 2), MEDLINE (OvidSP) (January 1993 to June 2009), EMBASE (OvidSP) (January 1993 to June 2009), PsycINFO (OvidSP) (January 1993 to June 2009), CINAHL (EbscoHOST) (January 1993 to June 2009), LILACS (January 1993 to June 2009) and African Health Anthology (January 1993 to June 2009). We also reviewed grey literature (including trial registers) and reference lists of articles. We included randomised controlled trials (RCTs), quasi-randomised controlled trials (QRCTs), controlled before-after (CBA) studies, or interrupted time series (ITS) studies with at least three time points before and after the intervention. We included studies assessing mobile phone messaging for communicating results of medical tests, between a healthcare provider or 'treatment buddy' and patient. We only included studies in which it was possible to assess the effects of mobile phone messaging independent of other technologies or interventions.

  3. Investigations of nephrotoxicity caused by ionic and non-ionic contrast media in rats with previously damaged and not previously damaged kidneys and special view to urinary enzyme determinations

    International Nuclear Information System (INIS)

    Hofmeister, R.

    1988-01-01

    In this study ionic (meglumine amidotrizoate) and non-ionic contrast media (SHH 340 AB, Iohexol, Iopromide, Iosimide and Iopamidol) were tested for their nephrotoxicity in rats. During the experiment detections of urea nitrogen, serum creatinine and urinary enzymes as well as histological examinations of the kidneys were carried out for the diagnosis of acute renal damage. The results obtained in this study demonstrate that rats are not very sensitive to non-ionic contrast media with regard to kidney damage and determinations of urinary enzymes are valuable for the diagnosis of contrast media induced acute kidney damage in living animals. (orig./MG) [de

  4. Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.

    Directory of Open Access Journals (Sweden)

    Maria I Zervou

    Full Text Available Treatment strategies blocking tumor necrosis factor (anti-TNF have proven very successful in patients with rheumatoid arthritis (RA, showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown. The aim of this study was to validate five single nucleotide polymorphisms (SNPs of PTPRC, CD226, AFF3, MyD88 and CHUK gene loci that have previously been reported to predict anti-TNF outcome. In addition, two markers of RA susceptibility, namely TRAF1/C5 and STAT4 were assessed, in a cohort of anti-TNF-treated RA patients, from the homogeneous Greek island of Crete, Greece. The RA patient cohort consisted of 183 patients treated with either of 3 anti-TNF biologic agents (infliximab, adalimumab and etanercept from the Clinic of Rheumatology of the University Hospital of Crete. The SNPs were genotyped by TaqMan assays or following the Restriction Fragments Length Polymorphisms (RFLPs approach. Disease activity score in 28 joints (DAS28 at baseline and after 6 months were available for all patients and analysis of good versus poor response at 6 months was performed for each SNP. None of the 7 genetic markers correlated with treatment response. We conclude that the gene polymorphisms under investigation are not strongly predictive of anti-TNF response in RA patients from Greece.

  5. Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.

    Science.gov (United States)

    Zervou, Maria I; Myrthianou, Efsevia; Flouri, Irene; Plant, Darren; Chlouverakis, Gregory; Castro-Giner, Francesc; Rapsomaniki, Panayiota; Barton, Anne; Boumpas, Dimitrios T; Sidiropoulos, Prodromos; Goulielmos, George N

    2013-01-01

    Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown. The aim of this study was to validate five single nucleotide polymorphisms (SNPs) of PTPRC, CD226, AFF3, MyD88 and CHUK gene loci that have previously been reported to predict anti-TNF outcome. In addition, two markers of RA susceptibility, namely TRAF1/C5 and STAT4 were assessed, in a cohort of anti-TNF-treated RA patients, from the homogeneous Greek island of Crete, Greece. The RA patient cohort consisted of 183 patients treated with either of 3 anti-TNF biologic agents (infliximab, adalimumab and etanercept) from the Clinic of Rheumatology of the University Hospital of Crete. The SNPs were genotyped by TaqMan assays or following the Restriction Fragments Length Polymorphisms (RFLPs) approach. Disease activity score in 28 joints (DAS28) at baseline and after 6 months were available for all patients and analysis of good versus poor response at 6 months was performed for each SNP. None of the 7 genetic markers correlated with treatment response. We conclude that the gene polymorphisms under investigation are not strongly predictive of anti-TNF response in RA patients from Greece.

  6. Reduced live-birth rates after IVF/ICSI in women with previous unilateral oophorectomy: results of a multicentre cohort study.

    Science.gov (United States)

    Lind, Tekla; Holte, Jan; Olofsson, Jan I; Hadziosmanovic, Nermin; Gudmundsson, Johannes; Nedstrand, Elizabeth; Lood, Mikael; Berglund, Lars; Rodriguez-Wallberg, Kenny

    2018-02-01

    Is there a reduced live-birth rate (LBR) after IVF/ICSI treatment in women with a previous unilateral oophorectomy (UO)? A significantly reduced LBR after IVF/ICSI was found in women with previous UO when compared with women with intact ovaries in this large multicentre cohort, both crudely and after adjustment for age, BMI, fertility centre and calendar period and regardless of whether the analysis was based on transfer of embryos in the fresh cycle only or on cumulative results including transfers using frozen-thawed embryos. Similar pregnancy rates after IVF/ICSI have been previously reported in case-control studies and small cohort studies of women with previous UO versus women without ovarian surgery. In all previous studies multiple embryos were transferred. No study has previously evaluated LBR in a large cohort of women with a history of UO. This research was a multicentre cohort study, including five reproductive medicine centres in Sweden: Carl von Linné Clinic (A), Karolinska University Hospital (B), Uppsala University Hospital (C), Linköping University Hospital (D) and Örebro University Hospital (E). The women underwent IVF/ICSI between January 1999 and November 2015. Single embryo transfer (SET) was performed in approximately 70% of all treatments, without any significant difference between UO exposed women versus controls (68% versus 71%), respectively (P = 0.32), and a maximum of two embryos were transferred in the remaining cases. The dataset included all consecutive treatments and fresh and frozen-thawed cycles. The exposed cohort included 154 women with UO who underwent 301 IVF/ICSI cycles and the unexposed control cohort consisted of 22 693 women who underwent 41 545 IVF/ICSI cycles. Overall, at the five centres (A-E), the exposed cohort underwent 151, 34, 35, 41 and 40 treatments, respectively, and they were compared with controls of the same centre (18 484, 8371, 5575, 4670 and 4445, respectively). The primary outcome was LBR, which was

  7. Results of microbiological Investigations of Orbital Station MIR Environment

    Science.gov (United States)

    Novikova, N.

    15-year experience of orbital station MIR service demonstrated that specifically modified space vehicle environment allows to consider spaceship habitats as a certain ecological niche of microbial community development and functioning, which was formed from the organisms of different physiological and taxonomical groups. As a result of on-board experiments and revision of interior and equipment more than 234 microorganisms were identified. They were represented by technophylic specia, which cause material damage, as well as potential pathogens (bacteria, actinomyces spp, fungi), which capable to grow on artificial substrates. Resident colonization of interior and equipment of space habitat by bacterial and fungal associations, taking place during long-term microbiota exposure on cosmophysic, physic-chemical and biological factors, which is accompanied by appearance of technological and medical risks, capable to provide significant influence on safety of humans and reliability of space equipment. These risks are due to such processes: biodestruction of synthetic and organic polymeres, biocorrosion of metals, biofoulding of surfaces (biofilms), formation of obturation in vital activity support system, occurrence of biodisturbances resulting in devise and equipment failure, occurrence and development of supertolerants and other variants with unpredictable attributes, which are expressed as a result of phenotypical and genotypical modifications. Based on the information from results of in-flight and laboratory microbiological investigations, the following suppositions can be made to characterize evolution of the microbial community aboard long-operating space vehicle: - environment of a long-operating piloted space vehicle may be a peculiar kind of ecological niche for development and reproduction of bacilli and fungi belonging to particular species, - bacteriofungal associations primarily reside on decorative-finish and structural materials of space interior and

  8. Preliminary results of spatially resolved ECR ion beam profile investigations

    International Nuclear Information System (INIS)

    Panitzsch, L.; Stalder, M.; Wimmer-Schweingruber, R.F.

    2012-01-01

    The profile of an ion beam produced in an Electron Cyclotron Resonance Ion Source (ECRIS) can vary greatly depending on the source settings and the ion-optical tuning. Strongly focussed ion beams form circular structures (hollow beams) as predicted by simulations and observed in experiments. Each of the rings is predicted to be dominated by ions with same or at least similar m/q-ratios due to ion-optical effects. To check this we performed a series of preliminary investigations to test the required tuning capabilities of our ion source. This includes beam focussing (A) and beam steering (B) using a 3D-movable extraction. Having tuned the source to deliver a beam of strongly focussed ions of different ion species and having steered this beam to match the transmittance area of the sector magnet we also recorded the ion charge state distribution of the strongly focussed beam profile at different, spatially limited positions (C). The preliminary results will be introduced within this paper: it appears that our 3D-movable extraction is very efficient to steer and to focus the beam strongly. The paper is followed by the slides of the presentation. (authors)

  9. Targeted MRI/TRUS fusion-guided biopsy in men with previous prostate biopsies using a novel registration software and multiparametric MRI PI-RADS scores: first results.

    Science.gov (United States)

    Tewes, Susanne; Hueper, Katja; Hartung, Dagmar; Imkamp, Florian; Herrmann, Thomas R W; Weidemann, Juergen; Renckly, Stefan; Kuczyk, Markus A; Wacker, Frank; Peters, Inga

    2015-11-01

    To evaluate a novel system for MRI/TRUS fusion-guided biopsy for detection of prostate cancer (PCa) in patients with previous negative prostate biopsy and determine diagnostic accuracy when using the Prostate Imaging Reporting and Data System (PI-RADS) for multiparametric magnetic resonance imaging (mpMRI) as proposed by the European Society of Urogenital Radiology. Thirty-nine men with clinical suspicion of PCa and history of previous prostate biopsy underwent mpMRI on a 3-T MRI. In total, 72 lesions were evaluated by the consensus of two radiologists. PI-RADS scores for each MRI sequence, the sum of the PI-RADS scores and the global PI-RADS were determined. MRI/TRUS fusion-guided targeted biopsy was performed using the BioJet™ software combined with a transrectal ultrasound system. Image fusion was based on rigid registration. PI-RADS scores of the dominant lesion were compared with histopathological results. Diagnostic accuracy was determined using receiver operating characteristic curve analysis. MRI/TRUS fusion-guided biopsy was reliable and successful for 71 out of 72 lesions. The global PI-RADS score of the dominant lesion was significantly higher in patients with PCa (4.0 ± 1.3) compared to patients with negative histopathology (2.6 ± 0.8; p = 0.0006). Using a global PI-RADS score cut-off ≥4, a sensitivity of 85 %, a specificity of 82 % and a negative predictive value of 92 % were achieved. The described fusion system is dependable and efficient for targeted MRI/TRUS fusion-guided biopsy. mpMRI PI-RADS scores combined with a novel real-time MRI/TRUS fusion system facilitate sufficient diagnosis of PCa with high sensitivity and specificity.

  10. First results from the Cluster wideband plasma wave investigation

    Directory of Open Access Journals (Sweden)

    D. A. Gurnett

    2001-09-01

    Full Text Available In this report we present the first results from the Cluster wideband plasma wave investigation. The four Cluster spacecraft were successfully placed in closely spaced, high-inclination eccentric orbits around the Earth during two separate launches in July – August 2000. Each spacecraft includes a wideband plasma wave instrument designed to provide high-resolution electric and magnetic field wave-forms via both stored data and direct downlinks to the NASA Deep Space Network. Results are presented for three commonly occurring magnetospheric plasma wave phenomena: (1 whistlers, (2 chorus, and (3 auroral kilometric radiation. Lightning-generated whistlers are frequently observed when the spacecraft is inside the plasmasphere. Usually the same whistler can be detected by all spacecraft, indicating that the whistler wave packet extends over a spatial dimension at least as large as the separation distances transverse to the magnetic field, which during these observations were a few hundred km. This is what would be expected for nonducted whistler propagation. No case has been found in which a strong whistler was detected at one spacecraft, with no signal at the other spacecraft, which would indicate ducted propagation. Whistler-mode chorus emissions are also observed in the inner region of the magnetosphere. In contrast to lightning-generated whistlers, the individual chorus elements seldom show a one-to-one correspondence between the spacecraft, indicating that a typical chorus wave packet has dimensions transverse to the magnetic field of only a few hundred km or less. In one case where a good one-to-one correspondence existed, significant frequency variations were observed between the spacecraft, indicating that the frequency of the wave packet may be evolving as the wave propagates. Auroral kilometric radiation, which is an intense radio emission generated along the auroral field lines, is frequently observed over the polar regions. The

  11. First results from the Cluster wideband plasma wave investigation

    Directory of Open Access Journals (Sweden)

    D. A. Gurnett

    Full Text Available In this report we present the first results from the Cluster wideband plasma wave investigation. The four Cluster spacecraft were successfully placed in closely spaced, high-inclination eccentric orbits around the Earth during two separate launches in July – August 2000. Each spacecraft includes a wideband plasma wave instrument designed to provide high-resolution electric and magnetic field wave-forms via both stored data and direct downlinks to the NASA Deep Space Network. Results are presented for three commonly occurring magnetospheric plasma wave phenomena: (1 whistlers, (2 chorus, and (3 auroral kilometric radiation. Lightning-generated whistlers are frequently observed when the spacecraft is inside the plasmasphere. Usually the same whistler can be detected by all spacecraft, indicating that the whistler wave packet extends over a spatial dimension at least as large as the separation distances transverse to the magnetic field, which during these observations were a few hundred km. This is what would be expected for nonducted whistler propagation. No case has been found in which a strong whistler was detected at one spacecraft, with no signal at the other spacecraft, which would indicate ducted propagation. Whistler-mode chorus emissions are also observed in the inner region of the magnetosphere. In contrast to lightning-generated whistlers, the individual chorus elements seldom show a one-to-one correspondence between the spacecraft, indicating that a typical chorus wave packet has dimensions transverse to the magnetic field of only a few hundred km or less. In one case where a good one-to-one correspondence existed, significant frequency variations were observed between the spacecraft, indicating that the frequency of the wave packet may be evolving as the wave propagates. Auroral kilometric radiation, which is an intense radio emission generated along the auroral field lines, is frequently observed over the polar regions. The

  12. Safety and tolerability of frovatriptan in the acute treatment of migraine and prevention of menstrual migraine: Results of a new analysis of data from five previously published studies.

    Science.gov (United States)

    MacGregor, E Anne; Pawsey, Stephen P; Campbell, John C; Hu, Xiaojun

    2010-04-01

    Triptans are a recommended first-line treatment for moderate to severe migraine. Using clinical trial data, we evaluated the safety and tolerability of frovatriptan as acute treatment (AT) and as short-term preventive (STP) therapy for menstrual migraine (MM). Data from 2 Phase III AT trials (AT1: randomized, placebo controlled, 1 attack; AT2: 12-months, noncomparative, open label) and 3 Phase IIIb STP trials in MM (MMP1 and MMP2: randomized, placebo controlled, double blind, 3 perimenstrual periods; MMP3: open label, noncomparative, 12 perimenstrual periods) were analyzed. In AT1, patients treated each attack with frovatriptan 2.5 mg, sumatriptan 100 mg, or placebo. In AT2, they used frovatriptan 2.5 mg. In MMP1 and MMP2, women administered frovatriptan 2.5 mg for 6 days during the perimenstrual period, taking a loading dose of 2 or 4 tablets on day 1, followed by once-daily or BID frovatriptan 2.5 mg, respectively; in MMP3, they used BID frovatriptan 2.5 mg. In AT1, which was previously published in part, group differences in adverse events (AEs) were analyzed using the Fisher exact test, and response rates were compared using logistic regression. Post hoc analyses of sustained pain-free status with no AEs (SNAE) and sustained pain response with no AEs (SPRNAE) were performed using a 2-sample test for equality of proportions without continuity correction. For AT2 and the STP studies, data were summarized using descriptive statistics. Results of individual safety analyses for the STP studies were previously reported; the present report includes new results from a pooled analysis of MMP1 and MMP2 and a new analysis of MMP3 in which AEs were coded using Medical Dictionary for Regulatory Activities version 8.0. AT1 included 1206 patients in the safety group; AT2 included 496. In the STP studies, safety data were collected for 1487 women. In AT1 and AT2, 85.6% and 88.3%, respectively, of enrolled patients were women. Overall, AEs were generally mild to moderate (AT

  13. Mirror activity in the human brain while observing hand movements: a comparison between EEG desynchronization in the mu-range and previous fMRI results.

    Science.gov (United States)

    Perry, Anat; Bentin, Shlomo

    2009-07-28

    Mu (mu) rhythms are EEG oscillations between 8-13 Hz distinguished from alpha by having more anterior distribution and being desynchronized by motor rather than visual activity. Evidence accumulating during the last decade suggests that the desynchronization of mu rhythms (mu suppression) might be also a manifestation of a human Mirror Neuron System (MNS). To further explore this hypothesis we used a paradigm that, in a previous fMRI study, successfully activated this putative MNS in humans. Our direct goal was to provide further support for a link between modulation of mu rhythms and the MNS, by finding parallels between the reported patterns of fMRI activations and patterns of mu suppression. The EEG power in the mu range has been recorded while participants passively observed either a left or a right hand, reaching to and grasping objects, and compared it with that recorded while participants observed the movement of a ball, and while observing static grasping scenes or still objects. Mirroring fMRI results (Shmuelof, L., Zohary, E., 2005. Dissociation between ventral and dorsal fMRI activation during object and action recognition. Neuron 47, 457-470), mu suppression was larger in the hemisphere contra-lateral to the moving hand and larger when the hands grasped different objects in different ways than when the movement was repetitive. No suppression was found while participants observed still objects but mu suppression was also found while seeing static grasping postures. These data are discussed in light of similar parallels between modulations of alpha waves and fMRI while recording EEG in the magnet. The present data support a link between mu suppression and a human MNS.

  14. Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trial

    NARCIS (Netherlands)

    Coppens, Michiel; Synhorst, David; Eikelboom, John W.; Yusuf, Salim; Shestakovska, Olga; Connolly, Stuart J.

    2014-01-01

    The AVERROES double-blinded, randomized trial demonstrated that apixaban reduces the risk of stroke or systemic embolism (SSE) by 55% compared with aspirin without an increase in major bleeding in patients with atrial fibrillation either who previously tried but failed vitamin K antagonists (VKA)

  15. Differences in Stem Cell Processing Lead to Distinct Secretomes Secretion-Implications for Differential Results of Previous Clinical Trials of Stem Cell Therapy for Myocardial Infarction.

    Science.gov (United States)

    Wernly, Bernhard; Gonçalves, Inês; Kiss, Attila; Paar, Vera; Mösenlechner, Tobias; Leisch, Michael; Santer, David; Motloch, Lukas Jaroslaw; Klein, Klaus U; Tretter, Eva V; Kretzschmar, Daniel; Podesser, Bruno; Jung, Christian; Hoppe, Uta C; Lichtenauer, Michael

    2017-09-01

    Stem cell therapy for acute myocardial infarction (AMI) seemed to be a promising therapy, however, large clinical trials brought differential outcome. It has been shown that paracrine effects of secretomes of stem cells rather than cell therapy might play a fundamental role. The present study seeks to compare cell processing protocols of clinical trials and investigate effects of differential cell culture conditions on chemokine secretion and functional effects. Different secretomes are compared regarding IL-8, VEGF, MCP-1, and TNF-alpha secretion. Secretome mediated effects are evaluated on endothelial cell (HUVEC) tube formation and migration. Cardioprotective signaling kinases in human cardiomyocytes are determined by Western immunoblotting. Cells processed according to the REPAIR-AMI protocol secrete significantly higher amounts of IL-8 (487.3 ± 1231.1 vs 9.1 ± 8.2 pg mL -1 ; p Cell processing conditions have a major impact on the composition of the secretome. The REPAIR-AMI secretome significantly enhances proangiogenic chemokine secretion, angiogenesis, cell migration, and cardioprotective signaling pathways. These results might explain differential outcomes between clinical trials. Optimizing cell processing protocols with special regards to paracrine factors, might open a new therapeutic concept for improving patient outcome. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Office and ambulatory blood pressure control with a fixed-dose combination of candesartan and hydrochlorothiazide in previously uncontrolled hypertensive patients: results of CHILI CU Soon

    Directory of Open Access Journals (Sweden)

    Bramlage P

    2011-12-01

    Full Text Available Thomas Mengden1, Reinhold Hübner2, Peter Bramlage31Kerckhoff-Klinik GmbH, Bad Nauheim, 2Takeda Pharma GmbH, Aachen, 3Institut für Kardiovaskuläre Pharmakologie und Epidemiologie, Mahlow, GermanyBackground: Fixed-dose combinations of candesartan 32 mg and hydrochlorothiazide (HCTZ have been shown to be effective in clinical trials. Upon market entry we conducted a noninterventional study to document the safety and effectiveness of this fixed-dose combination in an unselected population in primary care and to compare blood pressure (BP values obtained during office measurement (OBPM with ambulatory blood pressure measurement (ABPM.Methods: CHILI CU Soon was a prospective, noninterventional, noncontrolled, open-label, multicenter study with a follow-up of at least 10 weeks. High-risk patients aged ≥18 years with previously uncontrolled hypertension were started on candesartan 32 mg in a fixed-dose combination with either 12.5 mg or 25 mg HCTZ. OBPM and ABPM reduction and adverse events were documented.Results: A total of 4131 patients (52.8% male with a mean age of 63.0 ± 11.0 years were included. BP was 162.1 ± 14.8/94.7 ± 9.2 mmHg during office visits at baseline. After 10 weeks of candesartan 32 mg/12.5 mg or 25 mg HCTZ, mean BP had lowered to 131.7 ± 10.5/80.0 ± 6.6 mmHg (P < 0.0001 for both comparisons. BP reduction was comparable irrespective of prior or concomitant medication. In patients for whom physicians regarded an ABPM to be necessary (because of suspected noncontrol over 24 hours, ABP at baseline was 158.2/93.7 mmHg during the day and 141.8/85.2 mmHg during the night. At the last visit, BP had significantly reduced to 133.6/80.0 mmHg and 121.0/72.3 mmHg, respectively, resulting in 20.8% being normotensive over 24 hours (<130/80 mmHg. The correlation between OBPM and ABPM was good (r = 0.589 for systolic BP and r = 0.389 for diastolic BP during the day. Of those who were normotensive upon OBPM, 35.1% had high ABPM during the

  17. Structural investigations of biogenic iron oxide samples. Preliminary results

    International Nuclear Information System (INIS)

    Balasoiu, M.; Kuklin, A.I.; Orelovich, O.L.; Kovalev, Yu.S.; Arzumanyan, G.M.; Kurkin, T.S.; Stolyar, S.V.; Iskhakov, R.S.; Rajkher, Yu.L.

    2008-01-01

    Some preliminary results on morphology and structure of iron oxide particles formed inside Klebsiella oxytoca bacteria are presented. In particular, by means of optical microscopy, scanning electron microscopy and small-angle X-ray scattering the effect of the bacteria age (the duration of growth) on the nanoparticles properties is studied

  18. Results of investigations at the Ahuachapan geothermal field, El Salvador

    Energy Technology Data Exchange (ETDEWEB)

    Dennis, B.; Goff, F.; Van Eeckhout, E.; Hanold, B. (comps.)

    1990-04-01

    Well logging operations were performed in eight of the geothermal wells at Ahuachapan. High-temperature downhole instruments, including a temperature/rabbit, caliper, fluid velocity spinner/temperature/pressure (STP), and fluid sampler, were deployed in each well. The caliper tool was used primarily to determine if chemical deposits were present in well casings or liners and to investigate a suspected break in the casing in one well. STP logs were obtained from six of the eight wells at various flow rates ranging from 30 to 80 kg/s. A static STP log was also run with the wells shut-in to provide data to be used in the thermodynamic analysis of several production wells. The geochemical data obtained show a system configuration like that proposed by C. Laky and associates in 1989. Our data indicate recharge to the system from the volcanic highlands south of the field. Additionally, our data indicate encroachment of dilute fluids into deeper production zones because of overproduction. 17 refs., 50 figs., 10 tabs.

  19. Investigating Resulting Residual Stresses during Mechanical Forming Process

    Science.gov (United States)

    Akinlabi, Stephen A.; Fatoba, Olawale S.; Mashinini, Peter M.; Akinlabi, Esther T.

    2018-03-01

    Most manufacturing processes such as machining, welding, heat treatment, laser forming, laser cladding and, laser metal deposition, etc. are subjected to a form of heat or energy to change the geometrical shape thus changing the inherent engineering and structural properties of the material. These changes often cause the development of locked up stresses referred to as residual stresses as a result of these activities. This study reports on the residual stresses developed due to the mechanical forming process to maintain a suitable structural integrity for the formed components. The result of the analysis through the X-ray diffraction confirmed that residual stresses were induced in the manufactured parts and further revealed that residual stresses were compressive in nature as found in the parent material but with values less than the parent material.

  20. A Comparative Investigation of the Previous and New Secondary History Curriculum: The Issues of the Definition of the Aims and Objectives and the Selection of Curriculum Content

    Science.gov (United States)

    Dinc, Erkan

    2011-01-01

    Discussions on history teaching in Turkey indicate that the previous versions of the history curriculum and the pedagogy of history in the country bear many problems and deficiencies. The problems of Turkish history curriculum mainly arise from the perspectives it takes and the selection of its content. Since 2003, there have been extensive…

  1. RESULTS OF EXPERIMENTAL AND THEORETICAL INVESTIGATIONS OF THE HERRING SALTING

    Directory of Open Access Journals (Sweden)

    M. V. Shumanova

    2015-01-01

    Full Text Available To the salting process of fish many studies are devoted, both in experimental and in theoretical terms. Study of features of fish salting in historical terms can be divided into 3 groups. One group of researchers believes that osmotic pressure has a major influence during the salting process. Another group attributed this process to the influence of molecular diffusion. The third group considers that during this process takes place both osmosis and diffusion. Determination of the main characteristics (salinity, diffusion coefficients, time of salting, etc. is a very time-consuming task. This leads to the idea of searching for innovative research methods. Current state of science, in addition to theoretical solutions points to the possibility to determine the basic characteristics of salting and applying methods associated with the interaction of ultrasound and electromagnetic radiation with matter. In our studies, we have been producing laser beam scanning of salt solution and fish meat thickness. Scattered radiation is determined by the salt concentration, diffusion coefficients, the size of the diffusing particles. This method is called a photon correlation spectroscopy. It has been applied in our work. The dependence of the scattered light intensity on the concentration of sodium chloride solution (brine has been investigated. According to diffusion coefficient a diffusion in solution to herring skin a conclusion was made that salt solution obtains fractal structure and its size was determined. Also we determined diffusion coefficients depending on the temperature in the layers. The layers are brine-leather, leather, and herring meat thickness. The process of diffusion-osmotic equilibrium revealed at temperatures of 10-12 ° C. Suggested the possibility of higher quality of fish salting at low temperatures. On the basis of the selfsimilar solution of the differential diffusion equation, a formula for calculating time salting fish was obtained

  2. Robot-assisted radical prostatectomy in the setting of previous abdominal surgery: Perioperative results, oncological and functional outcomes, and complications in a single surgeon's series.

    Science.gov (United States)

    Di Pierro, Giovanni Battista; Grande, Pietro; Mordasini, Livio; Danuser, Hansjörg; Mattei, Agostino

    2016-12-01

    Data on safety and efficacy of robot-assisted radical prostatectomy (RARP) after previous abdominal surgery are scarce. Hence, we assessed perioperative, oncological and functional outcomes, and complications of RARP in patients with previous abdominal surgery after 1-year minimum follow-up. Prospectively collected data from 339 consecutive patients undergoing transperitoneal RARP by a single surgeon (AM) between November 2008 and May 2014 were analysed. Complications were classified according to Modified Clavien System. Biochemical recurrence (BCR) was defined as two consecutive PSA values ≥ 0.2 ng/ml. Functional outcomes were assessed using validated, self-administered questionnaires. In particular, only patients undergoing nerve-sparing RARP with no erectile dysfunction (baseline IIEF-5 score >21) and no use of phosphodiesterase-5 inhibitors preoperatively who were interested in erections and required no adjuvant therapy (radiation, orchiectomy and androgen-deprivation therapy) were evaluated concerning potency recovery. Patients without and with previous abdominal surgery were compared using Mann-Whitney and chi-square tests (or Fisher exact test). On 339 patients, 247 (71.6%) had not undergone previous abdominal surgery (Group 1) and 92 (28.4%) were pre-operated (Group 2). There were no statistically significant differences between Groups 1 and 2 regarding mean operative time (260 vs. 257 min; p = 0.597), median number of resected nodes (16 vs. 17; p = 0.484), mean length of stay (7.2 vs. 7.1 d; p = 0.151), positive surgical margin (12.5% vs. 16.3%; p = 0.233) and complication rates (26.7% vs. 31.5%; p = 0.187). Median (IQR) follow-up was 36 (12-48) months. For Groups 1 and 2, BCR-free survival rates were 78.5% and 79.8% (p = 0.467); continence rates were 97.9% and 100% (p = 0.329), whereas a potency recovery was achieved in 69.5% and 62.2% of patients (p = 0.460), respectively. Transperitoneal RARP is a safe and efficient treatment for

  3. Results of the physical-chemical investigations 1992; in tables

    International Nuclear Information System (INIS)

    1994-01-01

    The ARGE Weser, a cooperative effort of the Laender of Bremen, Hessen, Niedersachsen, Nordrhein-Westfalen and Thueringen for the abatement of pollution in the Weser river, issues a yearly report which contains the results of the water quality monitoring programmes in the Weser and Werra/Ulster rivers. There is an introductory section with a description of the measuring programme, a map containing the measuring points, a sampling schedule, sampling procedures, and the method of analysis. The report addresses scientific/technical services and universities. It permits a parameter-specific assessment of the water quality of the Weser river. (orig./EF) [de

  4. Magnetotelluric investigation across the Agri Valley: preliminary results.

    Science.gov (United States)

    Balasco, Marianna; Romano, Gerardo; Siniscalchi, Agata; Alfredo Stabile, Tony

    2017-04-01

    The Agri Valley is an axial zone of the Southern Apennines thrust belt chain with a strong seismogenic potential where two important energy technologies responsible for inducing/triggering seismicity are active: (1) the disposal at the Costa Molina 2 injection well of the wastewater produced during the exploitation of the biggest onshore oil field in west Europe (27 wells producing more than 80,000 barrels of crude oil per day), managed by the Eni S.p.A., and (2) the water loading and unloading operations in the Pertusillo artificial reservoir. It is recognized the possibility that the fluctuation of the water level inside the reservoir, due to the hydrological cycle for example, produces pressure perturbations at the bottom of reservoir, causing induced seismicity. Furthermore it is even more known the role of fluids in the rupture processes which could cause an increase of pore pressure specially at high rate of injection fluids and/or for the presence of weakening of preexisting faults. With the aim to better characterize and understand the physical processes involved in the observed induced/triggered seismicity, in 2016 a broadband seismic network, covering an area of about 20 km x 20 km nearby the Pertusillo Dam and Costa Molina2 well has been installed in the framework of SIR-MIUR project INSIEME (INduced Seismicity in Italy: Estimation, Monitoring, and sEismic risk mitigation) and a MagnetoTelluric (MT) survey has been performed. The MT investigation consists of 25 soundings aligned along 30 km profile oriented at about N40 direction, orthogonal with the strike of the major and noticeable geological structures and crossing both of the source that may induce/trigger seismicity. In this work, we present the preliminary 2D resistivity model which provides useful deep geophysical information for understanding the geological and structural setting of the Agri Valley. Moreover, the comparison of the resistivity model with the earthquake location as inferred from

  5. Preliminary results of hydrogeologic investigations Humboldt River Valley, Winnemucca, Nevada

    Science.gov (United States)

    Cohen, Philip M.

    1964-01-01

    . The resulting increase of the stage of the river causes the river to lose large amounts of water by infiltration to the ground-water reservoir in the study area. In addition, there is much recharge to the ground-water reservoir in the spring and early summer as a result of seepage losses from irrigation ditches and the downward percolation of some of the excess water applied for irrigation. The average net increase of ground water in storage in the deposits beneath and adjacent to the flood plain of the Humboldt River during the spring and early summer is about 10,000 acre-feet.

  6. Remedial investigation report for J-Field, Aberdeen Proving Ground, Maryland. Volume 1: Remedial investigation results

    International Nuclear Information System (INIS)

    Yuen, C. R.; Martino, L. E.; Biang, R. P.; Chang, Y. S.; Dolak, D.; Van Lonkhuyzen, R. A.; Patton, T. L.; Prasad, S.; Quinn, J.; Rosenblatt, D. H.; Vercellone, J.; Wang, Y. Y.

    2000-01-01

    This report presents the results of the remedial investigation (RI) conducted at J-Field in the Edgewood Area of Aberdeen Proving Ground (APG), a U.S. Army installation located in Harford County, Maryland. Since 1917, activities in the Edgewood Area have included the development, manufacture, and testing of chemical agents and munitions and the subsequent destruction of these materials at J-Field by open burning and open detonation. These activities have raised concerns about environmental contamination at J-Field. This RI was conducted by the Environmental Conservation and Restoration Division, Directorate of Safety, Health and Environmental Division of APG, pursuant to requirements outlined under the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (CERCLA). The RI was accomplished according to the procedures developed by the U.S. Environmental Protection Agency (EPA 1988). The RI provides a comprehensive evaluation of the site conditions, nature of contaminants present, extent of contamination, potential release mechanisms and migration pathways, affected populations, and risks to human health and the environment. This information will be used as the basis for the design and implementation of remedial actions to be performed during the remedial action phase, which will follow the feasibility study (FS) for J-Field

  7. Remedial investigation report for J-Field, Aberdeen Proving Ground, Maryland. Volume 1: Remedial investigation results

    Energy Technology Data Exchange (ETDEWEB)

    Yuen, C. R.; Martino, L. E.; Biang, R. P.; Chang, Y. S.; Dolak, D.; Van Lonkhuyzen, R. A.; Patton, T. L.; Prasad, S.; Quinn, J.; Rosenblatt, D. H.; Vercellone, J.; Wang, Y. Y.

    2000-03-14

    This report presents the results of the remedial investigation (RI) conducted at J-Field in the Edgewood Area of Aberdeen Proving Ground (APG), a U.S. Army installation located in Harford County, Maryland. Since 1917, activities in the Edgewood Area have included the development, manufacture, and testing of chemical agents and munitions and the subsequent destruction of these materials at J-Field by open burning and open detonation. These activities have raised concerns about environmental contamination at J-Field. This RI was conducted by the Environmental Conservation and Restoration Division, Directorate of Safety, Health and Environmental Division of APG, pursuant to requirements outlined under the Comprehensive Environmental Response, Compensation, and Liability Act, as amended (CERCLA). The RI was accomplished according to the procedures developed by the U.S. Environmental Protection Agency (EPA 1988). The RI provides a comprehensive evaluation of the site conditions, nature of contaminants present, extent of contamination, potential release mechanisms and migration pathways, affected populations, and risks to human health and the environment. This information will be used as the basis for the design and implementation of remedial actions to be performed during the remedial action phase, which will follow the feasibility study (FS) for J-Field.

  8. Everolimus Plus Exemestane in Advanced Breast Cancer: Safety Results of the BALLET Study on Patients Previously Treated Without and with Chemotherapy in the Metastatic Setting.

    Science.gov (United States)

    Generali, Daniele; Montemurro, Filippo; Bordonaro, Roberto; Mafodda, Antonino; Romito, Sante; Michelotti, Andrea; Piovano, Pierluigi; Ionta, Maria Teresa; Bighin, Claudia; Sartori, Donata; Frassoldati, Antonio; Cazzaniga, Marina Elena; Riccardi, Ferdinando; Testore, Franco; Vici, Patrizia; Barone, Carlo Antonio; Schirone, Alessio; Piacentini, Federico; Nolè, Franco; Molino, Annamaria; Latini, Luciano; Simoncini, Edda Lucia; Roila, Fausto; Cognetti, Francesco; Nuzzo, Francesco; Foglietta, Jennifer; Minisini, Alessandro Marco; Goffredo, Francesca; Portera, Giuseppe; Ascione, Gilda; Mariani, Gabriella

    2017-06-01

    The BALLET study was an open-label, multicenter, expanded access study designed to allow treatment with everolimus plus exemestane in postmenopausal women with hormone receptor-positive metastatic breast cancer progressed following prior endocrine therapy. A post hoc analysis to evaluate if previous chemotherapy in the metastatic setting affects the safety profile of the combination regimen of everolimus and exemestane was conducted on the Italian subset, as it represented the major part of the patients enrolled (54%). One thousand one hundred and fifty-one Italian patients were included in the present post hoc analysis, which focused on two sets of patients: patients who never received chemotherapy in the metastatic setting (36.1%) and patients who received at least one chemotherapy treatment in the metastatic setting (63.9%). One thousand one hundred and sixteen patients (97.0%) prematurely discontinued the study drug, and the main reasons reported were disease progression (39.1%), local reimbursement of everolimus (31.1%), and adverse events (AEs) (16.1%). The median duration of study treatment exposure was 139.5 days for exemestane and 135.0 days for everolimus. At least one AE was experienced by 92.5% of patients. The incidence of everolimus-related AEs was higher (83.9%) when compared with those that occurred with exemestane (29.1%), and the most commonly reported everolimus-related AE was stomatitis (51.3%). However, no significant difference in terms of safety related to the combination occurred between patients without and with chemotherapy in the metastatic setting. Real-life data of the Italian patients BALLET-related cohort were an adequate setting to state that previous chemotherapy did not affect the safety profile of the combination regimen of everolimus and exemestane. With the advent of new targeted agents for advanced or metastatic breast cancer, multiple lines of therapy may be possible, and components of the combined regimens can overlap from

  9. Culture Negative Listeria monocytogenes Meningitis Resulting in Hydrocephalus and Severe Neurological Sequelae in a Previously Healthy Immunocompetent Man with Penicillin Allergy

    DEFF Research Database (Denmark)

    Gaini, Shahin; Karlsen, Gunn Hege; Nandy, Anirban

    2015-01-01

    A previously healthy 74-year-old Caucasian man with penicillin allergy was admitted with evolving headache, confusion, fever, and neck stiffness. Treatment for bacterial meningitis with dexamethasone and monotherapy ceftriaxone was started. The cerebrospinal fluid showed negative microscopy...... the catheter. The patient had severe neurological sequelae. This case report emphasises the importance of covering empirically for Listeria monocytogenes in all patients with penicillin allergy with suspected bacterial meningitis. The case also shows that it is possible to have significant infection...... for bacteria, no bacterial growth, and negative polymerase chain reaction for bacterial DNA. The patient developed hydrocephalus on a second CT scan of the brain on the 5th day of admission. An external ventricular catheter was inserted and Listeria monocytogenes grew in the cerebrospinal fluid from...

  10. Drug-Induced QT Prolongation as a Result of an Escitalopram Overdose in a Patient with Previously Undiagnosed Congenital Long QT Syndrome

    Directory of Open Access Journals (Sweden)

    Paul Singh

    2014-01-01

    Full Text Available We present a case of drug-induced QT prolongation caused by an escitalopram overdose in a patient with previously undiagnosed congenital LQTS. A 15-year-old Caucasian female presented following a suicide attempt via an escitalopram overdose. The patient was found to have a prolonged QT interval with episodes of torsades de pointes. The patient was admitted to the telemetry unit and treated. Despite the resolution of the torsades de pointes, she continued to demonstrate a persistently prolonged QT interval. She was seen by the cardiology service and diagnosed with congenital long QT syndrome. This case illustrates the potential for an escitalopram overdose to cause an acute QT prolongation in a patient with congenital LQTS and suggests the importance of a screening electrocardiogram prior to the initiation of SSRIs, especially in patients at high risk for QT prolongation.

  11. Culture Negative Listeria monocytogenes Meningitis Resulting in Hydrocephalus and Severe Neurological Sequelae in a Previously Healthy Immunocompetent Man with Penicillin Allergy

    Directory of Open Access Journals (Sweden)

    Shahin Gaini

    2015-01-01

    Full Text Available A previously healthy 74-year-old Caucasian man with penicillin allergy was admitted with evolving headache, confusion, fever, and neck stiffness. Treatment for bacterial meningitis with dexamethasone and monotherapy ceftriaxone was started. The cerebrospinal fluid showed negative microscopy for bacteria, no bacterial growth, and negative polymerase chain reaction for bacterial DNA. The patient developed hydrocephalus on a second CT scan of the brain on the 5th day of admission. An external ventricular catheter was inserted and Listeria monocytogenes grew in the cerebrospinal fluid from the catheter. The patient had severe neurological sequelae. This case report emphasises the importance of covering empirically for Listeria monocytogenes in all patients with penicillin allergy with suspected bacterial meningitis. The case also shows that it is possible to have significant infection and inflammation even with negative microscopy, negative cultures, and negative broad range polymerase chain reaction in cases of Listeria meningitis. Follow-up spinal taps can be necessary to detect the presence of Listeria monocytogenes.

  12. Non-perforation tension pneumoperitoneum resulting from primary non-aerobic bacterial peritonitis in a previously healthy middle-aged man: a case report.

    Science.gov (United States)

    Milev, Ognyan Georgiev; Nikolov, Plamen Cekov

    2016-06-06

    Tension pneumoperitoneum is a rare surgical emergency in which free intraperitoneal gas accumulates under pressure. The known sources of free gas are perforated hollow viscera. We believe this is the first published case of a tension non-perforation pneumoperitoneum secondary to anaerobic gas production. This occurred in a background of primary non-aerobic bacterial peritonitis, which developed in an immunocompetent adult man. A previously healthy 45-year-old Bulgarian man presented with a 3-week history of abdominal pain. He displayed signs of shock, peritonitis, and abdominal compartment syndrome. A plain abdominal X-ray showed the pathognomonic "saddlebag sign" with his liver displaced downwards and medially. An emergency laparotomy released pressurized gas, accompanied by 3100 mL of foamy pus. A sudden hemodynamic deterioration occurred soon after decompression. The sources of infection and tension pneumoperitoneum were not found. The peritoneal exudate sample did not recover aerobes. A laparostomy was created and three planned re-operations were performed. During the second re-laparotomy we placed an intraperitoneal silo and his abdomen was closed with skin sutures. Definitive fascial closure was achieved through separation of his two rectus muscles from their posterior sheaths. He was discharged in good health on the 25th postoperative day. Our case provides evidence supporting the theory that anaerobic infection may underlie the etiology of tension pneumoperitoneum. Prior to decompressive laparotomy the patient should receive an intravenous volume bolus to compensate for possible hypotension. If laparostomy leads to lateralization of the rectus muscles with a gap of 6 cm or less, the posterior part of the components separation technique is effective in achieving fascial closure. We present an original classification of tension pneumoperitoneum defining it as primary or secondary.

  13. Factors Influencing Choices for Colorectal Cancer Screening Among Previously Unscreened African and Caucasian Americans: Findings from a Triangulation Mixed Methods Investigation

    OpenAIRE

    Ruffin, Mack T.; Creswell, John W.; Jimbo, Masahito; Fetters, Michael D.

    2009-01-01

    We investigated factors that influence choice of colorectal cancer (CRC) screening test and assessed the most- and least-preferred options among fecal occult blood testing (FOBT), flexible sigmoidoscopy, colonoscopy, and double contrast barium enema among adults with varied race, gender, and geographic region demographics. Mixed methods data collection consisted of 10 focus group interviews and a survey of the 93 focus group participants. Participants were ≥50 years of age and reported not ha...

  14. Final report : results of the 2007 targeted investigation at Hilton, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2008-04-29

    The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility in Hilton, Kansas, in 1954-1965. In 1992, carbon tetrachloride was first identified, at a concentration of 910 {micro}g/L, in groundwater from well GW01 at Hilton. This discovery occurred in association with the sale of the private grain storage facility on which well GW01 is located to the current owner, the Mid-Kansas Cooperative Association. The Kansas Department of Health and Environment conducted investigations at Hilton in 1992-1994. In 1996-1997, Argonne National Laboratory conducted Phase I and Phase II investigations on behalf of the CCC/USDA to characterize the distribution of the carbon tetrachloride contamination identified in well GW01, the stratigraphic units potentially hosting contaminant migration, and local hydrogeology in the Hilton area. The 2007 targeted investigation reported here focused specifically on the former CCC/USDA property at Hilton, west of the railroad tracks. (Until a property record search in 2005, the location of the CCC/USDA's former facility at Hilton was not known with certainty.) The objectives of the investigation, as implemented, were to (1) investigate for carbon tetrachloride contamination in the shallower soil and shallow aquifer units below the former CCC/USDA property and (2) investigate groundwater flow patterns. The key results of the 2007 targeted investigation are as follows: (1) No carbon tetrachloride or chloroform contamination was found in soil or groundwater below the former CCC/USDA facility. (2) The 2007 groundwater level data support a southwesterly direction for groundwater flow in the main Hilton aquifer (Equus Beds), consistent with findings of previous investigations. Contaminated well GW01 was confirmed to be upgradient from the former CCC/USDA facility. (3) The contaminants carbon tetrachloride, chloroform, and 1,2-dibromoethane (ethylene dibromide) were found in

  15. Results of paleoflood investigations for Spring, Rapid, Boxedler, and Elk Creeks, Black Hills, western South Dakota

    Science.gov (United States)

    Driscoll, Daniel G.; O'Connor, James E.; Harden, Tessa M.

    2012-01-01

    Flood-frequency analyses for the Black Hills area are especially important because of severe flooding of June 9–10, 1972, that was caused by a large mesoscale convective system and resulted in at least 238 deaths. This paper summarizes results of paleoflood investigations for six study reaches in the central Black Hills. Stratigraphic records and resulting long-term flood chronologies, locally extending more than 2,000 years, were combined with observed and historical flood information to derive flood-frequency estimates. Results indicate that floods as large as and even substantially larger than 1972 have affected most of the study reaches. Results of the paleoflood investigations provide better physically based information on low-probability floods than has been previously available, substantially improving estimates of the magnitude and frequency of large floods in the central Black Hills and reducing associated uncertainties. Collectively, the results provide insights regarding regional flood-generation processes and their spatial controls, enable approaches for extrapolation of results for hazard assessment beyond specific study reaches, and provide a millennial-scale perspective on the 1972 flooding.

  16. Integrating magnetic resonance imaging postprocessing results into neuronavigation for electrode implantation and resection of subtle focal cortical dysplasia in previously cryptogenic epilepsy.

    Science.gov (United States)

    Wellmer, Jörg; Parpaley, Yaroslav; von Lehe, Marec; Huppertz, Hans-Jürgen

    2010-01-01

    Focal cortical dysplasias (FCDs) are highly epileptogenic lesions. Surgical removal is frequently the best treatment option for pharmacoresistant epilepsy. However, subtle FCDs may remain undetected even after high-resolution magnetic resonance imaging (MRI). Morphometric MRI analysis, which compares the individual brain with a normal database, can facilitate the detection of FCDs. We describe how the results of normal database-based MRI postprocessing can be used to guide stereotactic electrode implantation and subsequent resection of lesions that are suspected to be FCDs. A presurgical evaluation was conducted on a 19-year-old woman with pharmacoresistant hypermotor seizures. Conventional high-resolution MRI was classified as negative for epileptogenic lesions. However, morphometric analysis of the spatially normalized MRI revealed abnormal gyration and blurring of the gray-white matter junction, which was suggestive of a small and deeply seated FCD in the left frontal lobe. The brain region highlighted by morphometric analysis was marked as a region of interest, transferred back to the original dimension of the individual MRI, and imported into a neuronavigation system. This allowed the region of interest-targeted stereotactic implantation of 2 depth electrodes, by which seizure onset was confirmed in the lesion. The electrodes also guided the final resection, which rendered the patient seizure-free. The lesion was histologically classified as FCD Palmini and Lüders IIB. Transferring normal database-based MRI postprocessing results into a neuronavigation system is a new and worthwhile extension of multimodal neuronavigation. The combination of resulting regions of interest with functional and anatomic data may facilitate planning of electrode implantation for invasive electroencephalographic recordings and the final resection of small or deeply seated FCDs.

  17. Can GSTM1 and GSTT1 polymorphisms predict clinical outcomes of chemotherapy in gastric and colorectal cancers? A result based on the previous reports

    Directory of Open Access Journals (Sweden)

    Liu H

    2016-06-01

    Full Text Available Haixia Liu,1,* Wei Shi,2,* Lianli Zhao,3 Dianlu Dai,4 Jinghua Gao,5 Xiangjun Kong6 1Department of Ultrasound, 2Office of Medical Statistics, 3Human Resource Department, 4Department of Surgical Oncology, 5Department of Medical Oncology, 6Central Laboratory, Cangzhou Central Hospital, Yunhe District, Cangzhou, People’s Republic of China *These authors contributed equally to this study and should be considered cofirst authors Background: Gastric and colorectal cancers remain the major causes of cancer-related death. Although chemotherapy improves the prognosis of the patients with gastrointestinal cancers, some patients do not benefit from therapy and are exposed to the adverse effects. The polymorphisms in genes including GSTM1 and GSTT1 have been explored to predict therapeutic efficacy; however, the results were inconsistent and inconclusive. Materials and methods: A systematic review and meta-analysis was performed by searching relevant studies about the association between the GSTM1 and GSTT1 polymorphisms and chemotherapy efficacy in gastrointestinal cancers in databases such as PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, and Wanfang database up to January 10, 2016. Subgroup analyses were also performed according to ethnicity, cancer type, evaluation criteria, study type, chemotherapy type, and age. Results: A total of 19 articles containing 3,217 cases were finally included. Overall analysis suggested that no significance was found between overall toxicity, neurotoxicity, neutropenia, gastrointestinal toxicity, tumor response, and progression-free survival, and the polymorphisms in GSTM1 and GSTT1, while GSTM1 polymorphism associated with overall survival (OS; hazard ratio =1.213, 95% confidence interval =1.060–1.388, P=0.005. Subgroup analyses suggested that neurotoxicity was associated with GSTM1 polymorphism in the Asian population, neutropenia was associated with GSTM1 polymorphism in palliative

  18. Factors Influencing Choices for Colorectal Cancer Screening Among Previously Unscreened African and Caucasian Americans: Findings from a Triangulation Mixed Methods Investigation

    Science.gov (United States)

    Ruffin, Mack T.; Creswell, John W.; Jimbo, Masahito

    2014-01-01

    We investigated factors that influence choice of colorectal cancer (CRC) screening test and assessed the most- and least-preferred options among fecal occult blood testing (FOBT), flexible sigmoidoscopy, colonoscopy, and double contrast barium enema among adults with varied race, gender, and geographic region demographics. Mixed methods data collection consisted of 10 focus group interviews and a survey of the 93 focus group participants. Participants were ≥50 years of age and reported not having been screened for colorectal cancer in the last ten years. Analyses examined differences by race, gender, and geographic location. Participants had modest knowledge about CRC and there were fewer correct answers to knowledge questions by African Americans. Participants recognized value of early detection, and identified health symptoms and their doctor's recommendation as influential for obtaining CRC screening. They chose colonoscopy and FOBT as the most preferred tests, while barium enema was least preferred. The analysis revealed intra-group variations in preference, though there were no significant differences by race, gender, or location. Openness of discussing this sensitive topic, lack of knowledge about colorectal cancer and screening costs, and diversity of preferences expressed within study groups suggest the importance of patient-physician dialogue about colorectal cancer screening options. New approaches to promoting colorectal cancer screening need to explore methods to facilitate patients establishing and expressing preferences among the screening options. PMID:19082695

  19. Constructing a paleo-DEM in an urban area by the example of the city of Aachen, Germany: Methods and previous results

    Science.gov (United States)

    Pröschel, Bernhard; Lehmkuhl, Frank

    2017-04-01

    Reconstructing paleo-landscapes in urban areas is always a special challenge since the research area often witnessed constant human impact over long time periods. Dense building development is a major difficulty, particularly in regard to accessibility to in-situ soils and archaeological findings. It is therefore necessary to use data from various sources and combine methods from different fields to gain a detailed picture of the former topography. The area, which is occupied by the city of Aachen today, looks back on a long history of human influence. Traces of human activity can be dated back to Neolithic time. The first architectural structures and the first road network were built by the Romans about 2000 years ago. From then on, the area of Aachen was more or less continuously inhabited forming today's city. This long history is represented by archaeological findings throughout the city. Several meters of settlement deposits, covering different eras, are present in many locations. Therefore, it can be assumed that the modern topography significantly differs from the pre-roman topography. The main objective of this project is a reconstruction of the paleo-topography of Aachen in order to gain new insights on the spatial preconditions that the first settlers found. Moreover, further attention is given to the question whether and to what extent a paleo-DEM can help to clarify specific open archaeological and historical questions. The main database for the reconstruction are the archaeological excavation reports of the past 150 years, provided by municipal and regional archives. After analyzing these written accounts, we linked this information to drill data, provided by the Geological Service of North Rhine-Westphalia. Together with additional sources like geological and hydrological maps, we generated a GIS-based terrain model. The result is a high-resolution terrain model, representing the undisturbed pre-roman topography of the inner city of Aachen without any

  20. Results From the Phase III Randomized Trial of Onartuzumab Plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non-Small-Cell Lung Cancer: METLung.

    Science.gov (United States)

    Spigel, David R; Edelman, Martin J; O'Byrne, Kenneth; Paz-Ares, Luis; Mocci, Simonetta; Phan, See; Shames, David S; Smith, Dustin; Yu, Wei; Paton, Virginia E; Mok, Tony

    2017-02-01

    Purpose The phase III OAM4971g study (METLung) examined the efficacy and safety of onartuzumab plus erlotinib in patients with locally advanced or metastatic non-small-cell lung cancer selected by MET immunohistochemistry whose disease had progressed after treatment with a platinum-based chemotherapy regimen. Patients and Methods Patients were randomly assigned at a one-to-one ratio to receive onartuzumab (15 mg/kg intravenously on day 1 of each 21-day cycle) plus daily oral erlotinib 150 mg or intravenous placebo plus daily oral erlotinib 150 mg. The primary end point was overall survival (OS) in the intent-to-treat population. Secondary end points included median progression-free survival, overall response rate, biomarker analysis, and safety. Results A total of 499 patients were enrolled (onartuzumab, n = 250; placebo, n = 249). Median OS was 6.8 versus 9.1 months for onartuzumab versus placebo (stratified hazard ratio [HR], 1.27; 95% CI, 0.98 to 1.65; P = .067), with a greater number of deaths in the onartuzumab arm (130 [52%] v 114 [46%]). Median progression-free survival was 2.7 versus 2.6 months (stratified HR, 0.99; 95% CI, 0.81 to 1.20; P = .92), and overall response rate was 8.4% and 9.6% for onartuzumab versus placebo, respectively. Exploratory analyses using MET fluorescence in situ hybridization status and gene expression showed no benefit for onartuzumab; patients with EGFR mutations showed a trend toward shorter OS with onartuzumab treatment (HR, 4.68; 95% CI, 0.97 to 22.63). Grade 3 to 5 adverse events were reported by 56.0% and 51.2% of patients, with serious AEs in 33.9% and 30.7%, for experimental versus control arms, respectively. Conclusion Onartuzumab plus erlotinib did not improve clinical outcomes, with shorter OS in the onartuzumab arm, compared with erlotinib in patients with MET-positive non-small-cell lung cancer.

  1. Investigation of sonar transponders for offshore wind farms: modeling approach, experimental setup, and results.

    Science.gov (United States)

    Fricke, Moritz B; Rolfes, Raimund

    2013-11-01

    The installation of offshore wind farms in the German Exclusive Economic Zone requires the deployment of sonar transponders to prevent collisions with submarines. The general requirements for these systems have been previously worked out by the Research Department for Underwater Acoustics and Marine Geophysics of the Bundeswehr. In this article, the major results of the research project "Investigation of Sonar Transponders for Offshore Wind Farms" are presented. For theoretical investigations a hybrid approach was implemented using the boundary element method to calculate the source directivity and a three-dimensional ray-tracing algorithm to estimate the transmission loss. The angle-dependence of the sound field as well as the weather-dependence of the transmission loss are compared to experimental results gathered at the offshore wind farm alpha ventus, located 45 km north of the island Borkum. While theoretical and experimental results are in general agreement, the implemented model slightly underestimates scattering at the rough sea surface. It is found that the source level of 200 dB re 1 μPa at 1 m is adequate to satisfy the detectability of the warning sequence at distances up to 2 NM (≈3.7 km) within a horizontal sector of ±60° if realistic assumptions about signal-processing and noise are made. An arrangement to enlarge the angular coverage is discussed.

  2. PREVIOUS SECOND TRIMESTER ABORTION

    African Journals Online (AJOL)

    PNLC

    PREVIOUS SECOND TRIMESTER ABORTION: A risk factor for third trimester uterine rupture in three ... for accurate diagnosis of uterine rupture. KEY WORDS: Induced second trimester abortion - Previous uterine surgery - Uterine rupture. ..... scarred uterus during second trimester misoprostol- induced labour for a missed ...

  3. Laparoscopy After Previous Laparotomy

    Directory of Open Access Journals (Sweden)

    Zulfo Godinjak

    2006-11-01

    Full Text Available Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

  4. Golimumab in patients with active rheumatoid arthritis who have previous experience with tumour necrosis factor inhibitors: results of a long-term extension of the randomised, double-blind, placebo-controlled GO-AFTER study through week 160

    NARCIS (Netherlands)

    Smolen, Josef S.; Kay, Jonathan; Landewé, Robert B. M.; Matteson, Eric L.; Gaylis, Norman; Wollenhaupt, Jurgen; Murphy, Frederick T.; Zhou, Yiying; Hsia, Elizabeth C.; Doyle, Mittie K.

    2012-01-01

    The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of

  5. Saturn's icy satellites investigated by Cassini-VIMS. II. Results at the end of nominal mission

    Science.gov (United States)

    Filacchione, G.; Capaccioni, F.; Clark, R.N.; Cuzzi, J.N.; Cruikshank, D.P.; Coradini, A.; Cerroni, P.; Nicholson, P.D.; McCord, T.B.; Brown, R.H.; Buratti, B.J.; Tosi, F.; Nelson, R.M.; Jaumann, R.; Stephan, K.

    2010-01-01

    We report the detailed analysis of the spectrophotometric properties of Saturn's icy satellites as derived by full-disk observations obtained by visual and infrared mapping spectrometer (VIMS) experiment aboard Cassini. In this paper, we have extended the coverage until the end of the Cassini's nominal mission (June 1st 2008), while a previous paper (Filacchione, G., and 28 colleagues [2007]. Icarus 186, 259-290, hereby referred to as Paper I) reported the preliminary results of this study. During the four years of nominal mission, VIMS has observed the entire population of Saturn's icy satellites allowing us to make a comparative analysis of the VIS-NIR spectral properties of the major satellites (Mimas, Enceladus, Tethys, Dione, Rhea, Hyperion, Iapetus) and irregular moons (Atlas, Prometheus, Pandora, Janus, Epimetheus, Telesto, Calypso, Phoebe). The results we discuss here are derived from the entire dataset available at June 2008 which consists of 1417 full-disk observations acquired from a variety of distances and inclinations from the equatorial plane, with different phase angles and hemispheric coverage. The most important spectrophotometric indicators (as defined in Paper I: I/F continua at 0.55 ??m, 1.822 ??m and 3.547 ??m, visible spectral slopes, water and carbon dioxide bands depths and positions) are calculated for each observation in order to investigate the disk-integrated composition of the satellites, the distribution of water ice respect to "contaminants" abundances and typical regolith grain properties. These quantities vary from the almost pure water ice surfaces of Enceladus and Calypso to the organic and carbon dioxide rich Hyperion, Iapetus and Phoebe. Janus visible colors are intermediate between these two classes having a slightly positive spectral slope. These results could help to decipher the origins and evolutionary history of the minor moons of the Saturn's system. We introduce a polar representation of the spectrophotometric

  6. Recent results of EPR and Moessbauer investigations on lattice dynamics in ammonium sulphate

    CERN Document Server

    Grecu, M N; Grecu, V V

    2003-01-01

    Recent results of the lattice dynamics investigation on ammonium sulfate are reported based on recent experiments carried out using using the non-destructive experimental technique of EPR and NGR. The main results confirm the presence and the contribution of a soft mode, which accompanied the paraferroelectric phase transition in the investigated crystal. (authors)

  7. Investigation into perfluoroalkyl substances (PFASs) in a cranberry bog: method development and sampling results.

    Science.gov (United States)

    Genualdi, Susan; Jeong, Nahyun; deJager, Lowri; Begley, Timothy

    2017-12-01

    The contamination of groundwater and surface water from previous uses of perfluoroalkyl substances (PFASs), particularly products containing the contaminants perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), has become a concern for drinking water and as a potential exposure route to the food supply. In 2016, the Food and Drug Administration (FDA) was asked to investigate a bog in Massachusetts where the surface water was believed to be contaminated with PFASs. As a result, a method was developed for the analysis of PFASs in cranberries, and water and fruit from the affected bog were evaluated. A QuEChERS method was developed and validated for PFOA, PFOS, and six additional shorter-chain PFASs. Method recoveries ranged from 60% to 115% for validation spikes performed at 10, 20 and 40 ng g -1 and method detection limits ranged from 0.2 to 5.6 ng g -1 . Bog water samples were analysed using Environmental Protection Agency (EPA) method 537 for PFOA, PFOS and four additional short-chain PFASs. Surface water concentrations for PFOS ranged from 16 to 122 ng L -1 and input water concentrations were 132 ng L -1 and 206 ng L -1 . Of the eight water samples, seven had water concentrations that exceeded the EPA health advisory level for PFOS of 70 ng L -1 . Of the 42 cranberry samples analysed, none had detects of PFOA or PFOS above their method detection limits (0.4 and 0.5 ng g -1 , respectively), nor any of the other short-chain PFASs.

  8. Major results of geophysical investigations at Yucca Mountain and vicinity, southern Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Oliver, H.W.; Ponce, D.A. [eds.] [Geological Survey, Menlo Park, CA (United States); Hunter, W.C. [ed.] [Geological Survey, Denver, CO (United States). Yucca Mountain Project Branch

    1995-12-31

    In the consideration of Yucca Mountain as a possible site for storing high level nuclear waste, a number of geologic concerns have been suggested for study by the National Academy of Sciences which include: (1) natural geologic and geochemical barriers, (2) possible future fluctuations in the water table that might flood a mined underground repository, (3) tectonic stability, and (4) considerations of shaking such as might be caused by nearby earthquakes or possible volcanic eruptions. This volume represents the third part of an overall plan of geophysical investigation of Yucca Mountain, preceded by the Site Characterization Plan (SCP; dated 1988) and the report referred to as the Geophysical White Paper, Phase 1, entitled Status of Data, Major Results, and Plans for Geophysical Activities, Yucca Mountain Project (Oliver and others, 1990). The SCP necessarily contained uncertainty about applicability and accuracy of methods then untried in the Yucca Mountain volcano-tectonic setting, and the White Paper, Phase 1, focused on summarization of survey coverage, data quality, and applicability of results. For the most part, it did not present data or interpretation. The important distinction of the current volume lies in presentation of data, results, and interpretations of selected geophysical methods used in characterization activities at Yucca Mountain. Chapters are included on the following: gravity investigations; magnetic investigations; regional magnetotelluric investigations; seismic refraction investigations; seismic reflection investigations; teleseismic investigations; regional thermal setting; stress measurements; and integration of methods and conclusions. 8 refs., 60 figs., 2 tabs.

  9. Major results of geophysical investigations at Yucca Mountain and vicinity, southern Nevada

    International Nuclear Information System (INIS)

    Oliver, H.W.; Ponce, D.A.; Hunter, W.C.

    1995-01-01

    In the consideration of Yucca Mountain as a possible site for storing high level nuclear waste, a number of geologic concerns have been suggested for study by the National Academy of Sciences which include: (1) natural geologic and geochemical barriers, (2) possible future fluctuations in the water table that might flood a mined underground repository, (3) tectonic stability, and (4) considerations of shaking such as might be caused by nearby earthquakes or possible volcanic eruptions. This volume represents the third part of an overall plan of geophysical investigation of Yucca Mountain, preceded by the Site Characterization Plan (SCP; dated 1988) and the report referred to as the Geophysical White Paper, Phase 1, entitled Status of Data, Major Results, and Plans for Geophysical Activities, Yucca Mountain Project (Oliver and others, 1990). The SCP necessarily contained uncertainty about applicability and accuracy of methods then untried in the Yucca Mountain volcano-tectonic setting, and the White Paper, Phase 1, focused on summarization of survey coverage, data quality, and applicability of results. For the most part, it did not present data or interpretation. The important distinction of the current volume lies in presentation of data, results, and interpretations of selected geophysical methods used in characterization activities at Yucca Mountain. Chapters are included on the following: gravity investigations; magnetic investigations; regional magnetotelluric investigations; seismic refraction investigations; seismic reflection investigations; teleseismic investigations; regional thermal setting; stress measurements; and integration of methods and conclusions. 8 refs., 60 figs., 2 tabs

  10. GPA-MDS: A Visualization Approach to Investigate Genetic Architecture among Phenotypes Using GWAS Results.

    Science.gov (United States)

    Wei, Wei; Ramos, Paula S; Hunt, Kelly J; Wolf, Bethany J; Hardiman, Gary; Chung, Dongjun

    2016-01-01

    Genome-wide association studies (GWAS) have identified tens of thousands of genetic variants associated with hundreds of phenotypes and diseases, which have provided clinical and medical benefits to patients with novel biomarkers and therapeutic targets. Recently, there has been accumulating evidence suggesting that different complex traits share a common risk basis, namely, pleiotropy. Previously, a statistical method, namely, GPA (Genetic analysis incorporating Pleiotropy and Annotation), was developed to improve identification of risk variants and to investigate pleiotropic structure through a joint analysis of multiple GWAS datasets. While GPA provides a statistically rigorous framework to evaluate pleiotropy between phenotypes, it is still not trivial to investigate genetic relationships among a large number of phenotypes using the GPA framework. In order to address this challenge, in this paper, we propose a novel approach, GPA-MDS, to visualize genetic relationships among phenotypes using the GPA algorithm and multidimensional scaling (MDS). This tool will help researchers to investigate common etiology among diseases, which can potentially lead to development of common treatments across diseases. We evaluate the proposed GPA-MDS framework using a simulation study and apply it to jointly analyze GWAS datasets examining 18 unique phenotypes, which helps reveal the shared genetic architecture of these phenotypes.

  11. The prevalence of abnormal results of annual investigations among diabetic patients with different risk factors

    International Nuclear Information System (INIS)

    Al-Faris, Eiad A.

    2000-01-01

    The basic theme of this study was to promote the use of risk approach and encourage selectively in requesting laboratory investigations. The objective was to estimate the proportion of abnormal results obtained from routinely requested annual investigations among the whole study population and the odds ratio of abnormal test results among patients with certain risk factors. A total of 459 diabetic patients aged 12 years and over, attending the primary care clinics of a university hospitals in Riyadh, Saudi Arabia, were included in this study. In this cross-sectional study, analysis of associations between patient's demographic characteristics and clinical findings (independent variables), and the results of annual investigations were conducted. A multiple logistic regression analysis was carried to identify certain independent variables associated with abnormal investigations. The proportion of patients who had abnormal electrocardiogram (ECG) was 23%, chest X-ray (CXR) 26% and liver function test (LFT) 9%. High systolic blood pressure (BP) and age were found to be important determinants of abnormal ECG and CXR. Patients who had high systolic BP (>140mm Hg) were found to be 2.39 times more likely to have abnormal ECG (OR=2.39), and their odds ratio of abnormal CXR was 2.33. Furthermore, for each 10-year increment in age, there was a 43% increased likelihood of abnormal ECG and 295 increase of abnormal CXR. Smokers were nine times more likely to have abnormal LFT (OR=9.26, 95% CI=2.29 tp 37.5). The disease duration and obesity were not found to have and independent association with the possibility of having abnormal results. The study results led to some tentative suggestions on guidelines for clinicians in their decision either to request annual investigations for all diabetic patients, or to restrict some investigations to certain group of patients. This was discussed and compared with the findings from the literature and other authorities recommendations. (author)

  12. Results of a seepage investigation at Bear Creek Valley, Oak Ridge, Tennessee, January through September 1994

    International Nuclear Information System (INIS)

    Robinson, J.A.; Johnson, G.C.

    1996-01-01

    A seepage investigation was conducted of 4,600 acres of Bear Creek Valley southwest of the Y-12 Plant, Oak Ridge, Tennessee, for the period of January through September 1994. The data was collected to help the Y-12 Environmental Restoration Program develop a better understanding of ground-water and surface-water interactions, recharge and discharge relations, and ground-water flow patterns. The project was divided into three phases: a reconnaissance and mapping of seeps, springs, and stream-measurement sites; a high base flow seepage investigation; and a low base flow seepage investigation. This report describes the results of the investigation. It includes a map showing measurement site locations and tables that list the coordinates for each site and measurements of discharge, pH, specific conductance, temperature, and dissolved oxygen

  13. From “Mr. Guthrie is profoundly mistaken ...” to “Our data do not seem to confirm the results of a previous study on...”: A diachronic study of polemicity in academic writing (1810-1995)

    OpenAIRE

    Françoise Salager-Meyer

    1999-01-01

    Objective: The objective of this paper is to investigate the quantitative and qualitative diachronic evolution of critical (Cr) with respect to non-critical (NCr) references in English medical discourse over a 185 year-period.Materials and Methods: We analyzed a corpus of 90 medical articles drawn from 34 different journals published between 1810 and 1995. Cr and NCr references were recorded in each paper and their frequency of occurrence was computed per 20 year-period. Results were analyzed...

  14. NEEDS for LHC experiment planning from results of very high energy cosmic ray Investigations (NEEDS-2

    Directory of Open Access Journals (Sweden)

    Petrukhin A.A.

    2015-01-01

    Full Text Available 12 years ago, at 12th ISVHECRI, a special NEEDS workshop was held to discuss future LHC data required for interpretation of cosmic ray experiments. Now, when the main task of LHC is solved – the Higgs boson is discovered – the question “What will be the next?” is very actual. In this paper the results of cosmic ray experiments at LHC energies are considered. Their possible explanation in the frame of a new model of production of quark-gluon matter blobs is discussed. The necessity to pass in LHC experiments from investigations of pp-interactions to investigations of nucleus-nucleus interactions is underlined since cosmic rays consist mainly of nuclei (≈ 60% which interact with nuclei of air. But namely in these nucleus-nucleus interactions many unusual results were obtained in cosmic ray investigations. Corresponding tasks for future LHC experiments are proposed.

  15. THE EFFECTS OF COOPERATIVE LEARNING MODEL GROUP INVESTIGATION AND MOTIVATION TOWARD PHYSICS LEARNING RESULTS MAN TANJUNGBALAI

    Directory of Open Access Journals (Sweden)

    Amalia Febri Aristi

    2014-12-01

    Full Text Available This study aimed to determine: (1 Is there a difference in student's learning outcomes with the application of learning models Investigation Group and Direct Instruction teaching model. (2 Is there a difference in students' motivation with the application of learning models Investigation Group and Direct Instruction teaching model, (3 Is there an interaction between learning models Investigation Group and Direct Instruction to improve students' motivation in learning outcomes Physics. This research is a quasi experimental. The study population was a student of class XII Tanjung Balai MAN. Random sample selection is done by randomizing the class. The instrument used consisted of: (1 achievement test (2 students' motivation questionnaire. The tests are used to obtain the data is shaped essay. The data in this study were analyzed using ANOVA analysis of two paths. The results showed that: (1 there were differences in learning outcomes between students who used the physics model of Group Investigation learning compared with students who used the Direct Instruction teaching model. (2 There was a difference in student's learning outcomes that had a low learning motivation and high motivation to learn both in the classroom and in the classroom Investigation Group Direct Instruction. (3 There was interaction between learning models Instruction Direct Group Investigation and motivation to learn in improving learning outcomes Physics.

  16. Concomitant and previous osteoporotic vertebral fractures.

    Science.gov (United States)

    Lenski, Markus; Büser, Natalie; Scherer, Michael

    2017-04-01

    Background and purpose - Patients with osteoporosis who present with an acute onset of back pain often have multiple fractures on plain radiographs. Differentiation of an acute osteoporotic vertebral fracture (AOVF) from previous fractures is difficult. The aim of this study was to investigate the incidence of concomitant AOVFs and previous OVFs in patients with symptomatic AOVFs, and to identify risk factors for concomitant AOVFs. Patients and methods - This was a prospective epidemiological study based on the Registry of Pathological Osteoporotic Vertebral Fractures (REPAPORA) with 1,005 patients and 2,874 osteoporotic vertebral fractures, which has been running since February 1, 2006. Concomitant fractures are defined as at least 2 acute short-tau inversion recovery (STIR-) positive vertebral fractures that happen concomitantly. A previous fracture is a STIR-negative fracture at the time of initial diagnostics. Logistic regression was used to examine the influence of various variables on the incidence of concomitant fractures. Results - More than 99% of osteoporotic vertebral fractures occurred in the thoracic and lumbar spine. The incidence of concomitant fractures at the time of first patient contact was 26% and that of previous fractures was 60%. The odds ratio (OR) for concomitant fractures decreased with a higher number of previous fractures (OR =0.86; p = 0.03) and higher dual-energy X-ray absorptiometry T-score (OR =0.72; p = 0.003). Interpretation - Concomitant and previous osteoporotic vertebral fractures are common. Risk factors for concomitant fractures are a low T-score and a low number of previous vertebral fractures in cases of osteoporotic vertebral fracture. An MRI scan of the the complete thoracic and lumbar spine with STIR sequence reduces the risk of under-diagnosis and under-treatment.

  17. Investigation of Election Results, Numbers of Party Members, and Opinion Polls in Germany

    Science.gov (United States)

    Schneider, Johannes J.; Hirtreiter, Christian

    Our publication focuses on two different but related topics in politics: in the first part of this publication, we investigate the influence of election results in the elections for the parliaments of the German states and for the German Diet (federal parliament) on the member numbers of the largest parties in the various states. In the second part of this publication, we consider the correlations between opinion polls and election results and focus on the question whether real election results can be predicted by opinion polls.

  18. Investigation of polarized-proton target materials by differential calorimetry: preliminary results

    International Nuclear Information System (INIS)

    Hill, D.A.; Hill, J.J.

    1980-01-01

    A simple differential calorimeter was designed and operated for an investigation of the thermodynamic properties of polarized target materials. The calibration and use of the calorimeter are discussed, after a brief exposition of our motivation for this work. The results of a preliminary study of target materials is presented with emphasis on the relevance of the glass state to dynamic polarization in chemically-doped targets

  19. Cosmic Ray Investigation in the Stratosphere and Space: Results from Instruments on Russian Satellites and Balloons

    Directory of Open Access Journals (Sweden)

    Yu. I. Logachev

    2013-01-01

    Full Text Available Selected activities aimed to investigate cosmic ray fluxes and to contribute to the understanding of the mechanisms behind, over a long-time period using space research tools in the former USSR/Russia and Slovakia, are reviewed, and some of the results obtained are presented. As the selection is connected with the institutes where the authors are working, it represents only a partial review of this wide topic.

  20. Small-angle neutron scattering investigations of Co-doped iron oxide nanoparticles. Preliminary results

    Science.gov (United States)

    Creanga, Dorina; Balasoiu, Maria; Soloviov, Dmitro; Balasoiu-Gaina, Alexandra-Maria; Puscasu, Emil; Lupu, Nicoleta; Stan, Cristina

    2018-03-01

    Preliminary small-angle neutron scattering investigations on aqueous suspensions of several cobalt doped ferrites (CoxFe3-xO4, x=0; 0.5; 1) nanoparticles prepared by chemical co-precipitation method, are reported. The measurements were accomplished at the YuMO instrument in function at the IBR-2 reactor. Results of intermediary data treatment are presented and discussed.

  1. Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: results from the recidivism of alcohol-impaired driving (ROAD) study.

    Science.gov (United States)

    Maenhout, Thomas M; Poll, Anneleen; Vermassen, Tijl; De Buyzere, Marc L; Delanghe, Joris R

    2014-01-01

    In several European countries, drivers under the influence (DUI), suspected of chronic alcohol abuse are referred for medical and psychological examination. This study (the ROAD study, or Recidivism Of Alcohol-impaired Driving) investigated the usefulness of indirect alcohol biomarkers for predicting drunk-driving recidivism in previously convicted drunk-driving offenders. The ROAD study is a prospective study (2009-13) that was performed on 517 randomly selected drivers in Belgium. They were convicted for drunk-driving for which their licence was confiscated. The initial post-arrest blood samples were collected and analysed for percentage carbohydrate-deficient transferrin (%CDT), transaminsase activities [alanine amino transferase (ALT), aspartate amino transferase (AST)], gamma-glutamyltransferase (γGT) and red cell mean corpuscular volume (MCV). The observation time for each driver was 3 years and dynamic. A logistic regression analysis revealed that ln(%CDT) (P drunk-driving. The ROAD index (which includes ln(%CDT), ln(γGT), -ln(ALT) and the sex of the driver) was calculated and had a significantly higher area under the receiver operator characteristic curve (0.71) than the individual biomarkers for drunk-driving recidivism. Drivers with a high risk of recidivating (ROAD index ≥ 25%; third tertile) could be distinguished from drivers with an intermediate risk (16% ≤ ROAD index drunk-driving. The association with gamma-glutamyltransferase, alanine amino transferase and the sex of the driver could have additional value for identifying drunk-drivers at intermediate risk of recidivism. Non-specific indirect alcohol markers, such as alanine amino transferase, gamma-glutamyltransferase, aspartate amino transferase and red cell mean corpuscular volume have minimal added value to % carbohydrate-deficient transferrin for distinguishing drunk drivers with a low or high risk of recidivism. © 2013 Society for the Study of Addiction.

  2. FInal Report: Site Investigation Results, 2009-2011, at Inman, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Sciences Div.

    2015-05-01

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility at the southern edge of the city of Inman, Kansas, from 1954 to 1965. During this time, commercial grain fumigants containing carbon tetrachloride were in common use by the grain storage industry to preserve grain in their facilities. In 1997, trace to low levels of carbon tetrachloride (below the maximum contamination level [MCL] of 5.0 μg/L) were detected in three private wells near the former grain storage facility at Inman, as part of a statewide USDA private well sampling program that was implemented by the Kansas Department of Health and Environment (KDHE) near former CCC/USDA facilities. No public water supply wells were identified in 1998 by the KDHE within 1 mi of the town. Carbon tetrachloride is the contaminant of primary concern at sites associated with grain storage operations. To determine whether the former CCC/USDA facility at Inman is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA agreed to conduct investigations at Inman. The investigations were performed by the Environmental Science Division of Argonne National Laboratory in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency of the USDA. Argonne, on behalf of the CCC/USDA, developed a Work Plan (Argonne 2007) and subsequently a Summary of Investigation Results and Proposed Work Plan (Appendix A) for a phased site investigation. The proposed work was approved by the KDHE (2007, 2011). The investigations were conducted from November 2009 to September 2011, as proposed in the two work plans. This report presents the findings of the 2009-2011 investigations at Inman.

  3. 50th Anniversary of Bilyar Archaeological Expedition: results and issues of Great Town investigation

    Directory of Open Access Journals (Sweden)

    Khuzin Fayaz Sh.

    2017-07-01

    Full Text Available The article outlines the main results of the investigation of Bilyar fortified settlement – a unique monument of medieval East-European archaeology located in Alexeyevsky District of the Tatarstan Republic. A small amount of information on Bilyar has remained in Ancient Russian chronicles (in which it is referred to as Great Town and the works by 10th – 14th century Arabic and Persian authors. The monument has been known to historians since 18th century, but its archaeological excavations only started in 1967. For 20 years researchers studied its fortifications, five urban burial grounds (including a necropolis of nobility in the centre of the town, discovered the ruined remains of three brick buildings and a white-stone Cathedral Mosque with a free-standing minaret, craft workshops (pottery, glass-making, blacksmithing and metallurgical, as well as tens and hundreds of common dwellings, utility structures and wells. The discoveries made by Bilyar expedition received a positive reaction from the archaeological community of the country. Since late 1980s the activity of the expedition gradually decreased due to the absence of adequate financing. Minor protective excavations were generally performed in the neighbouring villages. Investigation of the settlement it self continued in 2015. The necessity of continuing systematic excavations in Bilyar and the surrounding monuments is evident from both the scientific and practical viewpoints – application of investigation results for the purposes of tourism.

  4. Main results of BN-600 reactor stress-strain state investigations

    International Nuclear Information System (INIS)

    Panov, V.A.

    1983-01-01

    The development of BN-600 fast reactor plant needed the solution of a series of complex engineering problems including ones for confirming integrity of the most vital structural components. The particular attention was given to the main vessel since reactor availability end safe operation of the plant as a whole depend on vessel strength end integrity. The present report deals with the main results of theoretical and experimental investigations of the stress-strain state of BN-600 reactor vessel carried out during design, start-up and initial bringing the reactor to power

  5. Investigation of the results of therapy of anaplastic thyroid gland carcinomas

    International Nuclear Information System (INIS)

    Ooijen, M. van.

    1979-01-01

    The results of the treatment of 28 patients with an anaplastic thyroid gland carcinoma are investigated, to see whether an optimal therapy is indicated. The execution of an operation before radiotherapy does not appear to improve the prognosis (statistically this conclusion is not wholly justified). The presence of metastases at the beginning of the therapy gave rise to a worse prognosis than the absence of metastases. The combination treatment of chemotherapy and either surgery or radiotherapy was only applied to two patients so no conclusions can be made about its benefit. (C.F.)

  6. [Comparison of fecal examinations and worm collection results in an investigation of Ascaris lumbricoides infection].

    Science.gov (United States)

    Jiang, Wei-Sheng; Zeng, Xiao-Jun; Li, Hua-Zhong; Chen, Ying-Dan; Hong, Xian-Lin; Hu, Sheng-Zhu; Lan, Wei-Min; Chen, Yi-Yang

    2012-10-01

    To explore the relationship between fecal examinations and worm collection results in a community investigation of Ascaris lumbricoides infection. A total of 1 019 residents in Zhangxi Village, Nanchang County, Jiangxi Province were investigated with the Kato-Katz technique and worm collection after deworming. Among 1 019 residents investigated, the actual prevalence of A. lumbricoides was 30.23%, and the egg and worm positive rates were 20.41% and 23.75%, respectively. The average burden was 2.64 worms per person, and the heavier worm burden accounted for less proportion. The heavier the worm burden, the higher the probability to got egg in the feces. If one person had 7 worms or more, the probability to got eggs in his feces was 100%. Among people of false negative fecal examination, 61.00% of them were infected with male worms only, whereas 7.00% were infected with immature female worms with or without male worms, and 32.00% were infected with mature female worms with or without male worms. Totally 32.47% of infected people were missed by fecal examination, including 22.08% without egg excreted, and 10.39% missed because of the method itself. The egg positive rate is obviously lower than the actual infection rate, and the egg detection rate is correlated with the worm burden.

  7. Radon inside rooms. Results of a series of investigations in the Fichtelgebirge mountains

    International Nuclear Information System (INIS)

    Neroth, G.

    1993-01-01

    Radon measurements and structural surveys were carried out in 16 residential buildings of a village in the Upper Franconian Fichtelgebirge. It is shown by the results that the radon exposure inside the buildings is considerably influenced by the impermeability of the components in contact with the ground: old buildings with timber floors layed directly above the ground showed relatively high radon values of up to 3300 Bq/m 3 , whereas the concentrations measured in younger buildings with a continuous concrete floor slab were less than 100 Bq/m 3 . Based on the results of the investigations proposals were elaborated showing the structural measures suited for reducing the contents of radon in the most exposed buildings. (orig.) [de

  8. Investigation and analytical results of bituminized products in drums at filing room

    International Nuclear Information System (INIS)

    Shibata, Atsuhiro; Kato, Yoshiyuki; Sano, Yuichi; Kitajima, Takafumi; Fujita, Hideto

    1999-09-01

    This report describes the results of investigation of the bituminized products in drums, liquid waste in the receiving tank V21 and the bituminized mixture in the extruder. The investigation of the products in drums showed most of the unburned products filled after 28B had abnormality, such as hardened surfaces, caves and porous brittle products. The particle sizes of the salt fixed in bituminized products depended neither on batch number nor on feed rate. It indicates the fining of the salt particle caused by the decreased feed rate did not occur. The measured concentrations of metals and anions in the bituminized products showed no abnormality. The catalytic content was not recognized in the products. The infrared absorption spectra obtained with the bituminized products show the oxidation at the incident occurred without oxygen. There was no organic phase on the surface of liquid waste in V21. Chemical analysis and thermal analysis on the precipitate in V21 showed no abnormality. Concentration of sodium nitrate/nitrite in the mixture collected from the extruder was lower than normal products. These results show no chemical activation of the bituminized products. It can be concluded that the chemical characteristics of the products had little abnormality even around the incident. (author)

  9. Results of HHF tests and metallographic investigation of beryllium HHF mockups

    International Nuclear Information System (INIS)

    Giniaytulin, R.; Komarov, V.; Mazul, I.; Yablokov, N.; Watson, R.; Cadden, C.; Yang, N.

    2000-01-01

    The reliability of the beryllium-armoured elements for any fusion facilities strongly depends from the armour tile geometry and determines by the armour thickness and how it is castellated in the planar dimensions. The mockup with the tile dimensions of 5 x 5 x 5 mm demonstrated best results during the HHF tests at EBTS facility (SNLA). Thermal response test demonstrated the ultimate heat flux level fo 16.6 MW/m 2 without failure of the joint, melting of the beryllium surface limited the level of the heat flux. During thousand cycles by heat flux density of 13.5 MW/m 2 no damages in the Be/CuCrZr joint occurred that was approved by metallographic investigation of the tested and non-tested cross-sections. This paper presents the results of HHF testing with Be-armoured mockup that has optimized armour geometry, 2-D temperature analysis for testing conditions and the results of metallographic analysis. The results are discussed and the recommendations for armour dimensions are also made. (orig.)

  10. INITIAL RESULTS FROM INVESTIGATIONS TO ENHANCE THE PERFORMANCE OF HIGH TEMPERATURE IRRADIATION-RESISTANT THERMOCOUPLES

    International Nuclear Information System (INIS)

    Crepeau, John; Rempe, Joy; Wilkins, S. Curtis; Knudson, Darrell L.; Condie, Keith G.; Daw, Joshua

    2007-01-01

    New fuel, cladding, and structural materials offer the potential for safer and more economic energy from existing reactor and advanced nuclear reactor designs. However, insufficient data are available to characterize these materials in high temperature, radiation conditions. To evaluate candidate material performance, robust instrumentation is needed that can survive these conditions. However, traditional thermocouples either drift due to degradation at high temperatures (above 1100 C) or due to transmutation of thermocouple components. Thermocouples are needed which can withstand both high temperature and high radiation environments. To address this instrumentation need, the Idaho National Laboratory (INL) recently developed the design and evaluated the performance of a high temperature radiation-resistant thermocouple that contains commercially-available alloys of molybdenum and niobium (Rempe, 2006). Candidate thermocouple component materials were first identified based on their ability to withstand high temperature and radiation. Then, components were selected based on data obtained from materials interaction tests, ductility investigations, and resolution evaluations. Results from long duration (over 4000 hours) tests at high temperatures (up to 1400 C) and thermal cycling tests demonstrate the stability and reliability of the INL-developed design. Tests in INL's Advanced Test Reactor (ATR) are underway to demonstrate the in-pile performance of these thermocouples. However, several options have been identified that could further enhance the lifetime and reliability of the INL-developed thermocouples, allowing their use in higher temperature applications (up to at least 1700 C). A joint University of Idaho (UI) and INL University Nuclear Energy Research Initiative (UNERI) is underway to investigate these options and ultimately, provide recommendations for an enhanced thermocouple design. This paper presents preliminary results from this UI/INL effort. Results

  11. Investigation of the Results of Combined Reclamation on the Particular Stages of Grain Matrix Recovery

    Directory of Open Access Journals (Sweden)

    Łucarz M.

    2016-12-01

    Full Text Available In this article, there were presented the results of research on combined mechanical and thermal regeneration of waste moulding sand with furfuryl resin originated from one of national foundries manufacturing aluminium alloys castings. Attempts of mechanical reclamation were led on the REGMAS reclaimer enabling to realize preliminary and primary reclamation with use of two modes of mechanical interactions on waste moulding sand. In the first attempt the reclaimer worked without any additional regenerating elements, and as the second solution, the reclaimer operated with additional crushing and abrasive elements to increase the result of primary reclamation. Thermal reclamation was led in the prototypic thermal reclaimer, enabling to fully control the process of grain matrix recovery. As a result of completed investigations the small efficiency of mechanical reclamation was determined. However, use of combined regeneration allowed for obtaining grain matrix of high purity. Thermal regeneration was conducted in prototypic thermal reclaimer. Evaluation of reclaim (reclaimed material quality was carried out in the way of iginition losses and grain-size analysis, surface morphology and also by executing of strength testing of moulding sand prepared on obtained grain matrix for the particular reclamation operations.

  12. Investigation of topographical effects on rupture dynamics and resultant ground motions

    Science.gov (United States)

    Huang, Hanqing; Zhang, Zhenguo; Chen, Xiaofei

    2018-01-01

    In this work, we investigate the effect of irregular topography on the dynamic rupture and resultant ground motions using the curved grid finite-difference method. The research is based on spontaneous dynamic rupture on vertical strike-slip faults by varying the shapes and relative locations of irregular topography to the critical supershear transition distance. The results show that seismic energy of a supershear earthquake can be transmitted farther with large amplitudes. However, its ground motion near the fault is weaker than that caused by a subshear (namely the sub-Rayleigh) rupture. Whether the irregular topography exhibits stronger ground motion overall depends on the irregular topography's ability to prevent the subshear-to-supershear transition. Finally, we also discuss the effects of the strength parameter S and a larger size of the irregular topography on the resultant ground motion. The modellings of San Andreas Fault with real and inverted topographical surfaces show the implications of the topographical effects from the real earthquake.

  13. Investigations of aircrews exposure to cosmic radiation - results, conclusions and suggestions

    CERN Document Server

    Bilski, P; Horwacik, T; Marczewska, B; Ochab, E; Olko, P

    2002-01-01

    In frame of a research project undertaken in collaboration with Polish airlines LOT, analysis of aircrews exposure to cosmic radiation has been performed. The applied methods included measurements of radiation doses with thermoluminescent detectors (MTS-N, MCP-N) and track detectors (CR-39) and also calculations of route doses with the CARI computer code. The obtained results indicate that aircrews of nearly all airplanes, with exception of these flying only on ATR aircraft, exceed regularly or may exceed in some conditions, effective doses of 1 mSv. In case of Boeing-767 aircrews such exceeding occurs always, independently of solar activity. Investigations revealed, that during these periods of the solar cycle, when intensity of cosmic radiation is high, exceeding of 6 mSv level is also possible. These results indicate, that according to Polish and European regulations it is necessary for airlines to provide regular estimations of radiation exposure of aircrews. Basing on the obtained results a system for pe...

  14. Raman scattering investigation of the water-bridge phenomenon: Some preliminary results

    Directory of Open Access Journals (Sweden)

    Francesco Aliotta

    2010-09-01

    Full Text Available A floating water-bridge is formed if a high-voltage direct current is applied between two beakers filled of chemically pure water. Raman spectra of the OH-stretching region have been obtained at ambient condition of temperature and pressure. These preliminary results seem to indicate that the hydrogen-bond structure is only slightly modified by the presence of the electric field applied to form the floating water-bridge in agreement with recent neutron scattering investigation. In fact, the polarized Raman spectrum of the pure water and of the water-bridge is almost superimposable. We are planning to carry out further spectroscopic analysis, at different thermodynamic conditions, for better understanding the role played by the hydrogen-bond in driving the formation of the floating water-bridge.

  15. The magnetic field investigation on the ARASE (ERG) mission: Data characteristics and initial scientific results

    Science.gov (United States)

    Matsuoka, A.; Teramoto, M.; Nomura, R.; Nose, M.; Fujimoto, A.; Tanaka, Y.; Shinohara, M.; Nagatsuma, T.; Shiokawa, K.; Obana, Y.; Miyoshi, Y.; Takashima, T.; Shinohara, I.

    2017-12-01

    The ARASE (ERG) satellite was successfully launched on December 20 2016. A fluxgate magnetometer (MGF) was built for the ARASE satellite to measure DC and low-frequency magnetic field. The requirements to the magnetic field measurements by ARASE was defined as (1) accuracy of the absolute field intensity is within 5 nT (2) angular accuracy of the field direction is within 1 degree (3) measurement frequency range is from DC to 60Hz or wider. MGF measures the vector magnetic field with the original sampling frequency of 256 Hz. The dynamic range is switched between +/-8000nT and +/- 60000nT according to the background field intensity. The MGF initial checkout was carried on January 10th 2017, when the MGF normal performance and downlinked data were confirmed. The 5-m length MAST for the sensor was deployed on 17th January. The nominal operation of MGF started in March 2017. The MGF data are calibrated based on the results from the ground experiments and in-orbit data analysis. The MGF CDF files are distributed by the ARASE Science Center and available by Space Physics Environment Data Analysis Software (SPEDAS). The acceleration process of the charged particles in the inner magnetosphere is considered to be closely related to the deformation and perturbation of the magnetic field. Accurate measurement of the magnetic field is required to understand the acceleration mechanism of the charged particles, which is one of the major scientific objectives of the ARASE mission. We designed a fluxgate magnetometer which is optimized to investigate following topics; (1) accurate measurement of the background magnetic field - the deformation of the magnetic field and its relationship with the particle acceleration. (2) MHD waves - measurement of the ULF electromagnetic waves of frequencies about 1mHz (Pc4-5), and investigation of the radiation-belt electrons radially diffused by the resonance with the ULF waves. (3) EMIC waves - measurement of the electromagnetic ion

  16. From “Mr. Guthrie is profoundly mistaken ...” to “Our data do not seem to confirm the results of a previous study on...”: A diachronic study of polemicity in academic writing (1810-1995

    Directory of Open Access Journals (Sweden)

    Françoise Salager-Meyer

    1999-04-01

    Full Text Available Objective: The objective of this paper is to investigate the quantitative and qualitative diachronic evolution of critical (Cr with respect to non-critical (NCr references in English medical discourse over a 185 year-period.Materials and Methods: We analyzed a corpus of 90 medical articles drawn from 34 different journals published between 1810 and 1995. Cr and NCr references were recorded in each paper and their frequency of occurrence was computed per 20 year-period. Results were analyzed by means of Chi-square tests.Results: Our quantitative results indicate that in the corpus as a whole NCr significantly outweigh Cr references. When diachronically analyzed, our quantitative data revealed that the corpus analyzed could be divided into 2 blocks: Block A (1810-1929 and Block B (1930-1995, the cutting point being the 1930’s when NCr references started exhibiting a dramatic ascent. Our findings further showed that, proportionally speaking, Cr references were significantly more frequent in Block A than in Block B, but that NCr references significantly outnumbered Cr ones in Block B. Our quantitative data also indicated that the NCr/Cr reference ratio remained rather constant for the first 120 years studied, but that it changed radically from the 1930’s. Finally, our qualitative findings revealed that 19th and early 20th century Cr references were formulated in a much more direct, involved, personal and author-responsible manner than their mid- and late 20th century counterparts, the rhetorical features of the latter being a pronounced hedginess and the shifting of the disagreeement responsibility from a human agent (who became a detached and apparently neutral actor to an inanimate “talking fact/finding” which is then given a prominent thematic position.Conclusions: We conclude that 19th and early 20th century medical papers adopted a critical stand more frequently than mid- and late 20th century medical discourse did, and that the

  17. Investigation of short pulse effects in IR FELs and new simulation results

    CERN Document Server

    Asgekar, Vivek; Brunken, M; Casper, Lars; Genz, Harald; Grigore, Maria; Hessler, Christoph; Khodyachykh, Sergiy; Richter, Achim; Van der Meer, Alex F G

    2003-01-01

    The Darmstadt IR FEL is designed to generate wavelengths between 3 and 10 mum and driven by the superconducting electron linear accelerator. The pulsed electron beam has a peak current of 2.7 A leading to a small signal gain of 5%. Currently, investigations of the energy transfer process inside the undulator are performed using the 1D time-dependent simulation code FAST1D-OSC. We present simulation results for the power vs. different desynchronization and tapering parameters as well as a comparison with experimental data from the S-DALINAC IR-FEL. Furthermore, a compact autocorrelation system assuring a background-free measurement of the optical pulse length is described. In a first test experiment at FELIX, the autocorrelator has been tested at wavelengths 5.7 less than approximately equals lambda less than approximately equals 9.0 mum. The frequency doubling in a 2 mm-long ZnGeP//2-crystal resulted in a time resolution of 300 fs and a conversion efficiency of 5%.

  18. Post-test investigation result on the WWER-1000 fuel tested under severe accident conditions

    International Nuclear Information System (INIS)

    Goryachev, A.; Shtuckert, Yu.; Zwir, E.; Stupina, L.

    1996-01-01

    The model bundle of WWER-type were tested under SFD condition in the out-of-pile CORA installation. The objective of the test was to provide an information on the WWER-type fuel bundles behaviour under severe fuel damage accident conditions. Also it was assumed to compare the WWER-type bundle damage mechanisms with these experienced in the PWR-type bundle tests with aim to confirm a possibility to use the various code systems, worked our for PWR as applied to WWER. In order to ensure the possibility of the comparison of the calculated core degradation parameters with the real state of the tested bundle, some parameters have been measured on the bundle cross-sections under examination. Quantitative parameters of the bundle degradation have been evaluated by digital image processing of the bundle cross-sections. The obtained results are shown together with corresponding results obtained by the other participants of this investigation. (author). 3 refs, 13 figs

  19. Analysis of Systems Hardware Flown on LDEF-Results of the Systems Special Investigation Group

    National Research Council Canada - National Science Library

    Dursch, H

    1992-01-01

    .... The Systems Special Investigation Group (Systems SIG) was formed to investigate the effects of the long term exposure to LEO on systems related hardware and to coordinate and collate all systems analysis of LDEF hardware...

  20. Efficacy and Safety of Vorapaxar With and Without a Thienopyridine for Secondary Prevention in Patients With Previous Myocardial Infarction and No History of Stroke or Transient Ischemic Attack: Results from TRA 2°P-TIMI 50.

    Science.gov (United States)

    Bohula, Erin A; Aylward, Philip E; Bonaca, Marc P; Corbalan, Ramon L; Kiss, Robert G; Murphy, Sabina A; Scirica, Benjamin M; White, Harvey; Braunwald, Eugene; Morrow, David A

    2015-11-17

    Vorapaxar antagonizes protease-activated receptor 1, the primary receptor for thrombin on human platelets, and reduces recurrent thrombotic events in stable patients with a previous myocardial infarction (MI). We wished to determine whether the efficacy and safety of antiplatelet therapy with vorapaxar was modified by concurrent thienopyridine use. The Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events-Thrombolysis in Myocardial Infarction 50 (TRA 2°P-TIMI 50) was a randomized, double-blind, placebo-controlled trial of vorapaxar in 26,449 patients with previous atherothrombosis. This prespecified analysis included 16,897 patients who qualified with a MI in the preceding 2 weeks to 12 months and was restricted to patients without a history of stroke or transient ischemic attack given its contraindication in that population. Randomization was stratified on the basis of planned thienopyridine use. Thienopyridine was planned at randomization in 12,410 (73%). Vorapaxar significantly reduced the composite of cardiovascular death, MI, and stroke in comparison with placebo regardless of planned thienopyridine therapy (planned thienopyridine, hazard ratio, 0.80, 0.70-0.91, PGlobal Use of Strategies to Open Occluded Coronary Arteries (GUSTO) moderate or severe bleeding risk was increased with vorapaxar and was not significantly altered by planned thienopyridine (planned, hazard ratio, 1.50; 1.18-1.89, Phistory of previous MI, whether treated concomitantly with a thienopyridine or not. The relative risk of moderate or severe bleeding was similarly increased irrespective of thienopyridine use. URL: http://www.clinicaltrials.gov. Unique identifier: NCT00526474. © 2015 American Heart Association, Inc.

  1. Results from NNWSI [Nevada Nuclear Waste Storage Investigations] Series 2 bare fuel dissolution tests

    International Nuclear Information System (INIS)

    Wilson, C.N.

    1990-09-01

    The dissolution and radionuclide release behavior of spent fuel in groundwater is being studied by the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. Two bare spent fuel specimens plus the empty cladding hulls were tested in NNWSI J-13 well water in unsealed fused silica vessels under ambient hot cell air conditions (25 degree C) in the currently reported tests. One of the specimens was prepared from a rod irradiated in the H. B. Robinson Unit 2 reactor and the other from a rod irradiated in the Turkey Point Unit 3 reactor. Results indicate that most radionuclides of interest fall into three groups for release modeling. The first group principally includes the actinides (U, Np, Pu, Am, and Cm), all of which reached solubility-limited concentrations that were orders of magnitude below those necessary to meet the NRC 10 CFR 60.113 release limits for any realistic water flux predicted for the Yucca Mountain repository site. The second group is nuclides of soluble elements such as Cs, Tc, and I, for which release rates do not appear to be solubility-limited and may depend on the dissolution rate of fuel. In later test cycles, 137 Cs, 90 Sr, 99 Tc, and 129 I were continuously released at rates between about 5 x 10 -5 and 1 x 10 -4 of inventory per year. The third group is radionuclides that may be transported in the vapor phase, of which 14 C is of primary concern. Detailed test results are presented and discussed. 17 refs., 15 figs., 21 tabs

  2. Nutrition, hormones and prostate cancer risk: results from the European prospective investigation into cancer and nutrition.

    Science.gov (United States)

    Key, Timothy J

    2014-01-01

    Nutritional factors may influence the risk of developing prostate cancer, but understanding of this topic is poor. This chapter discusses research on this subject, mostly from the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort which includes 150,000 men recruited in the 1990s in eight European countries. So far the EPIC collaborators have published analyses of the relationship of prostate cancer risk with the intake of a range of foods and nutrients, and with blood-based markers of nutritional factors, on up to nearly 3,000 incident cases of prostate cancer. Most of the results of these analyses have been null, with no clear indication that the risk for prostate cancer is related to intakes of meat, fish, fruit, vegetables, fibre, fat or alcohol or with blood levels of fatty acids, carotenoids, tocopherols, B vitamins, vitamin D, or selenium. There is some evidence from EPIC that risk may be increased in men with a high intake of protein from dairy products, and analyses of hormone levels have shown that risk is higher in men with relatively high blood levels of insulin-like growth factor-I (IGF-I). More research is needed to better describe the relationships of prostate cancer risk with IGF-I and related hormones, and to better understand whether nutritional factors may influence risk through hormones or perhaps by other mechanisms.

  3. Investigation of film boiling thermal hydraulics under FCI conditions. Results of a numerical study

    Energy Technology Data Exchange (ETDEWEB)

    Dinh, T.N.; Dinh, A.T.; Nourgaliev, R.R.; Sehgal, B.R. [Div. of Nuclear Power Safety Royal Inst. of Tech. (RIT), Brinellvaegen 60, 10044 Stockholm (Sweden)

    1998-01-01

    Film boiling on the surface of a high-temperature melt jet or of a melt particle is one of key phenomena governing the physics of fuel-coolant interactions (FCIs) which may occur during the course of a severe accident in a light water reactor (LWR). A number of experimental and analytical studies have been performed, in the past, to address film boiling heat transfer and the accompanying hydrodynamic aspects. Most of the experiments have, however, been performed for temperature and heat flux conditions, which are significantly lower than the prototypic conditions. For ex-vessel FCIs, high liquid subcooling can significantly affect the FCI thermal hydraulics. Presently, there are large uncertainties in predicting natural-convection film boiling of subcooled liquids on high-temperature surfaces. In this paper, research conducted at the Division of Nuclear Power Safety, Royal Institute of Technology (RIT/NPS), Stockholm, concerning film-boiling thermal hydraulics under FCI condition is presented. Notably, the focus is placed on the effects of (1) water subcooling, (2) high-temperature steam properties, (3) the radiation heat transfer and (4) mixing zone boiling dynamics, on the vapor film characteristics. Numerical investigations are performed using a novel CFD modeling concept named as the local-homogeneous-slip model (LHSM). Results of the analytical and numerical studies are discussed with respect to boiling dynamics under FCI conditions. (author)

  4. Internal structure changes in bleached black human hair resulting from chemical treatments: A Raman spectroscopic investigation

    Science.gov (United States)

    Kuzuhara, Akio

    2014-11-01

    In order to investigate in detail the influence of chemical treatments (reduction, hydrolyzed eggwhite protein (HEWP) treatment, and oxidation) on damaged hair keratin fibers, the structure of cross-sections at various depths of excessively bleached (damaged) black human hair resulting from a permanent waving process was directly analyzed using Raman spectroscopy. It was found that L-cysteine (CYS) largely reacted with the gauche-gauche-gauche (GGG) conformation of disulfide (-SS-) groups (while CYS did not react with the trans-gauche-trans (TGT) conformation). In particular, not only the GGG content, but also the cysteic acid content existing throughout the cortex region of the excessively bleached human hair remarkably decreased by performing the oxidation process after reduction. On the other hand, the GGG content of the excessively bleached black human hair increased, while the TGT content decreased by performing the oxidation process after reduction and then HEWP treatment processes. From these experiments, the authors concluded that some of the keratin associated protein (KAP), which has a rich -SS- content and cysteic acid content was eluted from the cortex region along with the disconnection of -SS- groups, thereby leading to the remarkable reduction in the reconnection of -SS- groups of the excessively bleached black human hair after the permanent waving process (the reduction and oxidation processes). Also, the authors concluded that the HEWP treatment process in the permanent waving process caused the reconstruction of the KAP, thereby contributing to the acceleration of the reconnection of -SS- groups during the oxidation process.

  5. Investigation into River Sediments Toxicity as a Result of Inappropriate Waste Disposal

    Directory of Open Access Journals (Sweden)

    Lívia R. Souza

    2013-01-01

    Full Text Available Sediments of the São Francisco River basin (Brazil were investigated to determine the environmental consequences of incorrect disposal of wastes generated by a zinc industry. Surface sediments were characterized by X-ray diffraction (XRD and chemically analyzed by X-ray fluorescence (XRF. Total organic carbon (TOC, acid volatile sulfides (AVSs, and simultaneously extracted metals (SEMs were also determined. AVS/SEM procedure was employed to assess the bioavailability of the metals in sediments. XRD analyses indicated that the main phases in the sediments were kaolinite and quartz. The total concentration of Zn and Pb, near the old industrial discharge point, indicated high levels of contamination according to the sediment quality guidelines (SQGs. According to the AVS/SEM criteria, despite the high levels of zinc and lead in the sediments, the toxicity resulting from these metals is unlikely in most of the samples. However, in one of the samples, collected near the old industrial discharge point, the toxicity is uncertain—according to the USEPA criteria.

  6. Prophylaxis of irradiation-induced Diarrhea with smectite. Results of a placebo-controlled investigation

    International Nuclear Information System (INIS)

    Hombrink, J.; Froehlich, D.; Glatzel, M.; Krauss, A.; Thiel, H.J.; Meier, J.; Hamann, D.; Muecke, R.; Glaser, F.H.; Koest, S.

    2000-01-01

    Between April 1994 and May 1995, a total of 176 patients obtaining radiotherapy of the pelvis or the abdomen were evaluated in a double-blind, randomized placebo-controlled investigation regarding the prophylactic effect of smectite (=Colina trademark ) against radiotherapy-induced diarrhea. During the whole period of radiotherapy 85 patients obtained 2x6 g smectite daily and 91 patients received 2x6 g placebo. The primary end point of the analysis was the time to the first appearance of diarrhea (≥3 pappy stools). Results: All 176 patients were evaluated according to an intent-to-treat analysis. There was no significant difference between the prophylactic effects of smectite and placebo. For an explorative post-hoc analysis the total study group was split up into 2 subgroups, one with an irradiated small bowel volume ≤837.5 ml, the other with a small bowel volume >837.5 ml (median); the analysis indicated that the first subgroup showed a benefit for the smectite-treated patients in contrast to the placebo treatment (32 vs. 18 calendar days to the first appearance of diarrhea). This benefit was statistically not significant. Conclusion: Prophylactic application of smectite during irradiation of the pelvis and the abdomen can delay the development of radiotherapy-induced diarrhea, a statistical significance could not be verified neither in the total study group nor in the post-hoc subgroup analysis. (orig.) [de

  7. Analysis of systems hardware flown on LDEF. Results of the systems special investigation group

    Science.gov (United States)

    Dursch, Harry W.; Spear, W. Steve; Miller, Emmett A.; Bohnhoff-Hlavacek, Gail L.; Edelman, Joel

    1992-01-01

    The Long Duration Exposure Facility (LDEF) was retrieved after spending 69 months in low Earth orbit (LEO). LDEF carried a remarkable variety of mechanical, electrical, thermal, and optical systems, subsystems, and components. The Systems Special Investigation Group (Systems SIG) was formed to investigate the effects of the long duration exposure to LEO on systems related hardware and to coordinate and collate all systems analysis of LDEF hardware. Discussed here is the status of the LDEF Systems SIG investigation through the end of 1991.

  8. Residual stress investigation of copper plate and canister EB-Welds Complementary Results

    International Nuclear Information System (INIS)

    Gripenberg, H.

    2009-03-01

    The residual stresses in copper as induced by EB-welding were studied by specimens where the weld had two configurations: either a linear or a circumferential weld. This report contains the residual stress measurements of two plates, containing linear welds, and the full-scale copper lid specimen to which a hollow cylinder section had been joined by a circumferential EB-weld. The residual stress state of the EB-welded copper specimens was investigated by X-ray diffraction (XRD), hole drilling (HD) ring core (RC) and contour method (CM). Three specimens, canister XK010 and plates X251 and X252, were subjected to a thorough study aiming at quantitative determination of the residual stress state in and around the EB-welds using XRD for surface and HD and RC for spatial stress analysis. The CM maps one stress component over a whole cross section. The surface residual stresses measured by XRD represent the machined condition of the copper material. The XRD study showed that the stress changes towards compression close to the weld in the hollow cylinder, which indicates shrinkage in the hoop direction. According to the same analogy, the shrinkage in the axial direction is much smaller. The HD measurements showed that the stress state in the base material is bi-axial and, in terms of von Mises stress, 50 MPa for the plates and 20 MPa for the cylinder part of the canister. The stress state in the EB-welds of all specimens differs clearly from the stress state in the base material being more tensile, with higher magnitudes of von Mises stress in the plate than in the canister welds. The HD and RC results were obtained using linear elastic theory. The RC measurements showed that the maximum principal stress in the BM is close to zero near the surface and it becomes slightly tensile, 10 MPa, deeper under the surface. Welding pushed the general stress state towards tension with the maximum principal stress reaching 50 MPa, deeper than 5 mm below the surface in the weld. The

  9. Six-month outcome in unstable angina patients without previous myocardial infarction according to the use of tertiary cardiologic resources. RESCATE Investigators. Recursos Empleados en el Síndrome Coronario Agudo y Tiempos de Espera.

    Science.gov (United States)

    Lupón, J; Valle, V; Marrugat, J; Elosua, R; Serés, L; Pavesi, M; Freixa, R; Sanz, G; Masiá, R; Molina, L; Sala, J; Serra, J

    1999-12-01

    The study assessed whether varying accessibility of patients with unstable angina (UA) to coronary angiography and revascularization determined differing usages and outcomes. The appropriate use rate of coronary angiography and revascularization procedures in UA remains to be established. A total of 791 consecutive patients with UA without previous acute myocardial infarction (AMI) admitted to four reference teaching hospitals (one with tertiary facilities) were followed for six months. End points were six-month mortality and readmission for AMI, UA, heart failure, or severe ventricular arrhythmias. Patients admitted to the tertiary hospital were 3.27 (95% confidence interval [CI] 2.32 to 4.62) times more likely to undergo coronary angiography after adjustment for comorbidity and severity than were those admitted to nontertiary facilities (overall six-month use rates 70.1% and 48.3%, respectively). Revascularization procedures were performed in 36.2% of patients in the tertiary hospital and 24.6% in the others (p = 0.0007); adjusted relative risk (RR) 2.37 (95% CI 1.55 to 3.63). Median delay for urgent coronary angiography was shorter in the tertiary hospital (24 h vs. 4 days, p < 0.0002). Six-month mortality and readmission rates were similar in tertiary and nontertiary hospitals: 3.9% versus 5.3% and 16.9% versus 21.2%, respectively. Adjusted RR of death or readmission for the nontertiary hospitals was 1.23 (95% CI 0.57 to 2.67). The use of coronary angiography and revascularization procedures in UA patients with no previous AMI is higher in tertiary than in nontertiary hospitals, but the more selective use of these procedures in nontertiary centers does not imply worse outcome.

  10. Methodology and results of investigations of physical parameters of high-temperature reactors

    International Nuclear Information System (INIS)

    Cherepnin, Yu.S.; Chertkov, Yu.B.

    1995-01-01

    A physical investigations of reactors of stand complexes Baikal-1 and IGR have been carrying out more 30 years. Measuring methods of the physical investigations were divided into 2 groups: 1) methods for measuring of reactivity effects; 2) methods for measuring relative and absolute values of neutron flux and power release. The physical investigations on the reactors IVG-1 and IGR were carryied out under following conditions: during physical starts-up of regular variants of reactor cores; during energy starts-up of the reactors; before beginning of new loop chanel tests of the reactors; during research hot starts-up of the reactors the physical parameters were controled. The most full and authentic information about studied reactor have been providing by physical investigations. In 1984 physical investigations were carryied out on the IGR reactor and then the hot start-up of the mostest power and mostest large on fuel loading loop chanel was carryied out. This chanel contained 6 fuel assemblies with the summary fuel loading 3,06 kilogrammes of uranium and it was calculated for power equal to 20 MW. In 1988 the physical investigations for selection of project process chanels destined for new water cooled reactor core were carryied out. In 1993 the neutron-physical calculation on possibility of tests for the rector Nerva fuel element was carryied out. 9 refs., 4 figs

  11. Results from Investigations of Torsional Vibration in Turbine Set Shaft Systems

    Science.gov (United States)

    Taradai, D. V.; Deomidova, Yu. A.; Zile, A. Z.; Tomashevskii, S. B.

    2018-01-01

    The article generalizes the results obtained from investigations of torsional vibration in the shaft system of the T-175/210-12.8 turbine set installed at the Omsk CHPP-5 combined heat and power plant. Three different experimental methods were used to determine the lowest natural frequencies of torsional vibration excited in the shaft system when the barring gear is switched into operation, when the generator is synchronized with the grid, and in response to unsteady disturbances caused by the grid and by the turbine control and steam admission system. It is pointed out that the experimental values of the lowest natural frequencies (to the fourth one inclusively) determined using three different methods were found to be almost completely identical with one another, even though the shaft system was stopped in the experiments carried out according to one method and the shaft system rotated at the nominal speed in those carried out according to two other methods. The need to further develop the experimental methods for determining the highest natural frequencies is substantiated. The values of decrements for the first, third, and fourth natural torsional vibration modes are obtained. A conclusion is drawn from a comparison between the calculated and experimental data on the shaft system's static twisting about the need to improve the mathematical models for calculating torsional vibration. The measurement procedure is described, and the specific features pertinent to the way in which torsional vibration manifests itself as a function of time and turbine set operating mode under the conditions of its long-term operation are considered. The fundamental measurement errors are analyzed, and their influence on the validity of measured parameters is evaluated. With an insignificant level of free and forced torsional vibrations set up under the normal conditions of turbine set and grid operation, it becomes possible to exclude this phenomenon from the list of main factors

  12. Mediterranean diet and cognitive health: Initial results from the Hellenic Longitudinal Investigation of Ageing and Diet.

    Science.gov (United States)

    Anastasiou, Costas A; Yannakoulia, Mary; Kosmidis, Mary H; Dardiotis, Efthimios; Hadjigeorgiou, Giorgos M; Sakka, Paraskevi; Arampatzi, Xanthi; Bougea, Anastasia; Labropoulos, Ioannis; Scarmeas, Nikolaos

    2017-01-01

    The Mediterranean dietary pattern has been associated with a decreased risk of many degenerative diseases and cognitive function in particular; however, relevant information from Mediterranean regions, where the prototype Mediterranean diet is typically adhered to, have been very limited. Additionally, predefined Mediterranean diet (MeDi) scores with use of a priori cut-offs have been used very rarely, limiting comparisons between different populations and thus external validity of the associations. Finally, associations between individual components of MeDi (i.e., food groups, macronutrients) and particular aspects of cognitive performance have rarely been explored. We evaluated the association of adherence to an a priori defined Mediterranean dietary pattern and its components with dementia and specific aspects of cognitive function in a representative population cohort in Greece. Participants from the Hellenic Longitudinal Investigation of Ageing and Diet (HELIAD), an on-going population-based study, exploring potential associations between diet and cognitive performance in a representative sample from Greek regions, were included in this analysis. Diagnosis of dementia was made by a full clinical and neuropsychological evaluation, while cognitive performance was assessed according to five cognitive domains (memory, language, attention-speed, executive functioning, visuospatial perception) and a composite cognitive score. Adherence to MeDi was evaluated by an a priori score (range 0-55), derived from a detailed food frequency questionnaire. Among 1,865 individuals (mean age 73±6 years, 41% male), 90 were diagnosed with dementia and 223 with mild cognitive impairment. Each unit increase in the Mediterranean dietary score (MedDietScore) was associated with a 10% decrease in the odds for dementia. Adherence to the MeDi was also associated with better performance in memory, language, visuospatial perception and the composite cognitive score; the associations were

  13. Pain and other non-neurological adverse events in children with sickle cell anemia and previous stroke who received hydroxyurea and phlebotomy or chronic transfusions and chelation: results from the SWiTCH clinical trial.

    Science.gov (United States)

    Alvarez, Ofelia; Yovetich, Nancy A; Scott, J Paul; Owen, William; Miller, Scott T; Schultz, William; Lockhart, Alexandre; Aygun, Banu; Flanagan, Jonathan; Bonner, Melanie; Mueller, Brigitta U; Ware, Russell E

    2013-11-01

    To compare the non-neurological events in children with sickle cell anemia (SCA) and previous stroke enrolled in SWiTCH. The NHLBI-sponsored Phase III multicenter randomized clinical trial stroke with transfusions changing to hydroxyurea (SWiTCH) (ClinicalTrials.gov NCT00122980) compared continuation of chronic blood transfusion/iron chelation to switching to hydroxyurea/phlebotomy for secondary stroke prevention and management of iron overload. All randomized children were included in the analysis (intention to treat). The Fisher's Exact test was used to compare the frequency of subjects who experienced at least one SCA-related adverse event (AE) or serious adverse event (SAE) in each arm and to compare event rates. One hundred and thirty three subjects, mean age 13 ± 3.9 years (range 5.2-19.0 years) and mean time of 7 years on chronic transfusion at study entry, were randomized and treated. Numbers of subjects experiencing non-neurological AEs were similar in the two treatment arms, including SCA-related events, SCA pain events, and low rates of acute chest syndrome and infection. However, fewer children continuing transfusion/chelation experienced SAEs (P = 0.012), SCA-related SAEs (P = 0.003), and SCA pain SAEs (P = 0.016) as compared to children on the hydroxyurea/phlebotomy arm. The timing of phlebotomy did not influence SAEs. Older age at baseline predicted having at least 1 SCA pain event. Patients with recurrent neurological events during SWiTCH were not more likely to experience pain. In children with SCA and prior stroke, monthly transfusions and daily iron chelation provided superior protection against acute vaso-occlusive pain SAEs when compared to hydroxyurea and monthly phlebotomy. Copyright © 2013 Wiley Periodicals, Inc.

  14. Investigation results on water quality and volume of flowing-in water to the Yotsugi slag heap site. 2

    International Nuclear Information System (INIS)

    Naganuma, Masaki; Taki, Tomihiro; Takimoto, Sadao; Makita, A.

    2000-05-01

    Mining water flowing into the Yotsugi slag heap site at the Ningyo-toge Environment Technical Center is exhausted to a common river after carrying out the treatment of uranium and radium in the mining water at the previously settled mining water treatment facility and confirming it to be less than management target value on the river water within the site boundary regulated by the agreement on environmental conservation with Okayama prefecture and Kami-saihara mura. In order to elucidate some required treatment on every water system flowing-in the heap site as a part of reduction of flowing volume on taking action of the heap site, an investigation on its water quality and volume was carried out. As a result, it was confirmed on water quality that uranium values of every river were all less than their target values but radium values of them were all over their target values which necessitated conventional water treatment. And, on water volume, it was confirmed that flowing water volume from the exposed excavation site was reduced about 40% in comparison with same rain-fall before removing from rain water. (G.K.)

  15. Investigating the attainment of open government data objectives : Is there a mismatch between objectives and results?

    NARCIS (Netherlands)

    Zuiderwijk-van Eijk, AMG; Shinde, R.; Janssen, M.F.W.H.A.

    The objectives of open government data initiatives range from enhancing transparency and accountability to increasing innovation and participation. However, there is a lack of knowledge of the extent to which the objectives of open government data initiatives are achieved. This article investigates

  16. Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the Compass pilot randomised trial.

    Science.gov (United States)

    Canfell, Karen; Caruana, Michael; Gebski, Val; Darlington-Brown, Jessica; Heley, Stella; Brotherton, Julia; Gertig, Dorota; Jennett, Chloe J; Farnsworth, Annabelle; Tan, Jeffrey; Wrede, C David; Castle, Philip E; Saville, Marion

    2017-09-01

    Using primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%). Compass is an open-label randomised trial of 5-yearly HPV screening versus 2.5-yearly liquid-based cytology (LBC) screening. In the first phase, consenting women aged 25-64 years presenting for routine screening at 47 primary practices in Victoria, Australia, provided a cervical sample and were randomised at a central laboratory at a 1:2:2 allocation to (i) image-read LBC screening with HPV triage of low-grade cytology ('LBC screening'), (ii) HPV screening with those HPV16/18 positive referred to colposcopy and with LBC triage for other oncogenic (OHR) types ('HPV+LBC triage'), or (iii) HPV screening with those HPV16/18 positive referred to colposcopy and with dual-stained cytology triage for OHR types ('HPV+DS triage'). A total of 5,006 eligible women were recruited from 29 October 2013 to 7 November 2014 (recruitment rate 58%); of these, 22% were in the group age-eligible for vaccination. Data on 4,995 participants were analysed after 11 withdrawals; 998 were assigned to, and 995 analysed (99.7%) in, the LBC-screened group; 1,996 assigned to and 1,992 analysed (99.8%) in the HPV+LBC triage group; and 2,012 assigned to and 2,008 analysed (99.8%) in the HPV+DS triage group. No serious trial-related adverse events were reported. The main outcomes were colposcopy referral and detected CIN2+ rates at baseline screening, assessed on an intention

  17. Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the Compass pilot randomised trial

    Science.gov (United States)

    Canfell, Karen; Gebski, Val; Heley, Stella; Brotherton, Julia; Gertig, Dorota; Jennett, Chloe J.; Farnsworth, Annabelle; Castle, Philip E.; Saville, Marion

    2017-01-01

    Background Using primary human papillomavirus (HPV) testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+]) compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia’s HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%–77%). Methods and findings Compass is an open-label randomised trial of 5-yearly HPV screening versus 2.5-yearly liquid-based cytology (LBC) screening. In the first phase, consenting women aged 25–64 years presenting for routine screening at 47 primary practices in Victoria, Australia, provided a cervical sample and were randomised at a central laboratory at a 1:2:2 allocation to (i) image-read LBC screening with HPV triage of low-grade cytology (‘LBC screening’), (ii) HPV screening with those HPV16/18 positive referred to colposcopy and with LBC triage for other oncogenic (OHR) types (‘HPV+LBC triage’), or (iii) HPV screening with those HPV16/18 positive referred to colposcopy and with dual-stained cytology triage for OHR types (‘HPV+DS triage’). A total of 5,006 eligible women were recruited from 29 October 2013 to 7 November 2014 (recruitment rate 58%); of these, 22% were in the group age-eligible for vaccination. Data on 4,995 participants were analysed after 11 withdrawals; 998 were assigned to, and 995 analysed (99.7%) in, the LBC-screened group; 1,996 assigned to and 1,992 analysed (99.8%) in the HPV+LBC triage group; and 2,012 assigned to and 2,008 analysed (99.8%) in the HPV+DS triage group. No serious trial-related adverse events were reported. The main outcomes were colposcopy referral and detected CIN2+ rates at

  18. Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the Compass pilot randomised trial.

    Directory of Open Access Journals (Sweden)

    Karen Canfell

    2017-09-01

    Full Text Available Using primary human papillomavirus (HPV testing for cervical screening increases detection of high-grade cervical intraepithelial neoplastic lesions and invasive cancer (cervical intraepithelial neoplasia grade 2+ [CIN2+] compared to cytology, but no evaluation has been conducted in a population previously offered HPV vaccination. We aimed to assess colposcopy referral and CIN2+ detection rates for HPV-screened versus cytology-screened women in Australia's HPV-vaccinated population (by 2014, resident women ≤33 years had been age-eligible for HPV vaccination, with 3-dose uptake across age cohorts being about 50%-77%.Compass is an open-label randomised trial of 5-yearly HPV screening versus 2.5-yearly liquid-based cytology (LBC screening. In the first phase, consenting women aged 25-64 years presenting for routine screening at 47 primary practices in Victoria, Australia, provided a cervical sample and were randomised at a central laboratory at a 1:2:2 allocation to (i image-read LBC screening with HPV triage of low-grade cytology ('LBC screening', (ii HPV screening with those HPV16/18 positive referred to colposcopy and with LBC triage for other oncogenic (OHR types ('HPV+LBC triage', or (iii HPV screening with those HPV16/18 positive referred to colposcopy and with dual-stained cytology triage for OHR types ('HPV+DS triage'. A total of 5,006 eligible women were recruited from 29 October 2013 to 7 November 2014 (recruitment rate 58%; of these, 22% were in the group age-eligible for vaccination. Data on 4,995 participants were analysed after 11 withdrawals; 998 were assigned to, and 995 analysed (99.7% in, the LBC-screened group; 1,996 assigned to and 1,992 analysed (99.8% in the HPV+LBC triage group; and 2,012 assigned to and 2,008 analysed (99.8% in the HPV+DS triage group. No serious trial-related adverse events were reported. The main outcomes were colposcopy referral and detected CIN2+ rates at baseline screening, assessed on an intention

  19. Final Report: Results of Environmental Site Investigation at Sylvan Grove, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-09-01

    Sylvan Grove is located in western Lincoln County, approximately 60 mi west of Salina, Kansas (Figure 1.1). From 1954 to 1966, the Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility at the northeastern edge of Sylvan Grove. During this time, commercial grain fumigants containing carbon tetrachloride were in common use to preserve grain in storage. In 1998, the Kansas Department of Health and Environment (KDHE) found carbon tetrachloride above the maximum contaminant level (MCL) of 5 μg/L in groundwater from one private well used for livestock and lawn and garden watering. The 1998 KDHE sampling at Sylvan Grove was conducted under the USDA private well sampling program. To determine whether the former CCC/USDA facility at Sylvan Grove is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA proposed to conduct an environmental site investigation, in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency (FSA) of the USDA. Argonne National Laboratory, on behalf of the CCC/USDA, developed a work plan (Argonne 2012) for the site investigation and a supplemental work plan for indoor and ambient air sampling (Appendix A). The proposed work was approved by the KDHE (2012a, 2013). The investigations were performed by the Environmental Science Division of Argonne National Laboratory, on behalf of the CCC/USDA. The main activities for the site investigation were conducted in June 2012, and indoor and ambient air sampling was performed in February 2013. This report presents the findings of the investigations at Sylvan Grove.

  20. Correlação entre fratura por queda em idosos e uso prévio de medicamentos Correlation between fractures resulting from falls and previous drug use

    Directory of Open Access Journals (Sweden)

    Alberto Hamra

    2007-01-01

    Full Text Available O uso de medicamentos por idosos é freqüente e tem crescido a cada dia em virtude do aumento da expectativa de vida no Brasil. Algumas destas drogas quando administradas, podem provocar efeitos colaterais como tontura e diminuição dos reflexos podendo ocasionar quedas e conseqüentes fraturas. Este trabalho verificou se o uso de medicamentos pode ser considerado como fator de risco para fratura por queda no idoso. Para isso fez-se um estudo no ano de 2004 com 205 pacientes a partir de 60 anos de idade internados com fratura por queda e comparou-se estatisticamente com grupo-controle de 205 pacientes do mesmo grupo etário sem fratura. Verificou-se que o uso de medicamentos pode ser considerado como fator de risco para fratura por queda. Os resultados também podem servir como orientação para equipe médica, pacientes e seus familiares, no sentido de se tentar evitar quedas, principalmente quando o uso de medicamentos é necessário.The use of medication by elderly individuals is frequently and is constantly growing due to the increase of life expectance rates in Brazil. When some of these drugs are administered, they can cause collateral effects like dizziness and decreased reflex, potentially causing the occurrence of falls resulting in fractures. This study examined whether the use of medications by the elderly could be regarded as a risk factor to fractures resulting from falls. The study, conducted in 2004, assessed 205 hospitalized patients > 60 years old, with fractures resulting from falls. These patients were statistically compared to a control group (205 patients in the same age group and without fractures. We’ve found that the use of medication can be regarded as a risk factor to fractures resulting from falls. Our results could be useful to raise the awareness of doctors, patients and their families so that to avoid accidents when any drug therapy is required.

  1. Investigation about the Chrome Steel Wire Arc Spray Process and the Resulting Coating Properties

    Science.gov (United States)

    Wilden, J.; Bergmann, J. P.; Jahn, S.; Knapp, S.; van Rodijnen, F.; Fischer, G.

    2007-12-01

    Nowadays, wire-arc spraying of chromium steel has gained an important market share for corrosion and wear protection applications. However, detailed studies are the basis for further process optimization. In order to optimize the process parameters and to evaluate the effects of the spray parameters DoE-based experiments had been carried out with high-speed camera shoots. In this article, the effects of spray current, voltage, and atomizing gas pressure on the particle jet properties, mean particle velocity and mean particle temperature and plume width on X46Cr13 wire are presented using an online process monitoring device. Moreover, the properties of the coatings concerning the morphology, composition and phase formation were subject of the investigations using SEM, EDX, and XRD-analysis. These deep investigations allow a defined verification of the influence of process parameters on spray plume and coating properties and are the basis for further process optimization.

  2. BP-5 Remedial Investigation Slug-Test Characterization Results for Well 699-52-55A

    Energy Technology Data Exchange (ETDEWEB)

    Newcomer, Darrell R.

    2008-07-21

    Pacific Northwest National Laboratory conducted slug-test characterization at the final, completed BP-5 Remedial Investigation well 699-52-55A near the 200-East Area at the Hanford Site on April 22, 2008. The slug-test characterization was in support of the BP-5 Remedial Investigation. The portion of the unconfined aquifer tested is composed of sediments of the lower Ringold Formation and the underlying Elephant Mountain basalt flowtop. The basalt flowtop unit was included as part of the effective test-interval length for the slug-test analysis because the flowtop unit is hydraulically communicative with the unconfined aquifer. Estimates of hydraulic conductivity for the effective test-interval length represent composite values for the lower Ringold Formation and the underlying Elephant Mountain basalt flow top.

  3. WEGENER: Solid Body Dynamics Investigation of Venus. Results from Summer School Alpbach 2014.

    Science.gov (United States)

    Bialek, A.; Coyle, S.; Czeluschke, A.; Donaldson Hanna, K.; Donohoe, A.; Hu, H.; Koopmans, R.-J.; Lucchetti, A.; Mannel, T.; Nachon, M.; Nilsson, D.; Shelakhaev, N.; Suer, A.; Timoney, R.

    2015-10-01

    The work presented in this paper was performed by the Orange Team during Summer School Alpbach 2014, which mainly concerns about geophysics of terrestrial planets. A mission is designed to investigate the past and current tectonic and volcanic activity on Venus. During the mission, a simultaneous observations from topographic, magnetic and gravitational measurements will be performed and the combination of the information has the potential to provide an improved understanding of the formation and evolution of the planet.

  4. [Changes in bone structure according to the results of investigations on biosatellites of the "BION" series].

    Science.gov (United States)

    Kabitskaya, O E; Oganov, V S; Gordienko, K V; Bakulin, K V

    2014-01-01

    Noninvasive technologies of bone investigations measure largely the main skeletal sites and are not quite suitable to have a look at the bone internal organization in situ. However, there are data obtained noninvasively in experiments on board the space biosatellites. The review is dedicated to analysis and comparison of the evidence for the bone organic and mineral matrix restructuring due to microgravity. These changes have presumably evolved in the course of the system reaction of bone tissue and the whole skeleton.

  5. [Novel concepts in biology of diffuse endocrine system: results and future investigations].

    Science.gov (United States)

    Iaglov, V V; Iaglova, N V

    2012-01-01

    Diffuse endocrine system is a largest part of endocrine system of vertebrates. Recend findings showed that DES-cells are not neuroectodermal but have ectodermal, mesodermal, and entodermal ontogeny. The article reviews novel concept of diffuse endocrine system anatomy and physiology, functional role of DES hormones and poorly investigated aspects like DES-cell morphology, hormones secretion in normal and pathologic conditions. Further research of diffuse endocrine system has a great significance for biochemistry, morphology, and clinical medicine.

  6. Investigation of Long Term Cycle Stability - First Results of Metal Hydride Composites

    OpenAIRE

    Dieterich, Mila; Bürger, Inga; Linder, Marc; Wörner, Antje

    2014-01-01

    Reversible reactions of solid powders and hydrogen can be used for hydrogen storage as well as for thermal applications like heat storages or heat conversion systems. For all applications, one of the fundamental prerequisites is the cycle stability of the reaction material and - if required - its bulk structure. At the Institute of Technical Thermodynamics at the German Aerospace Center a test bench to investigate the cycle stability of reversible gas/solid-reactions has been developed and...

  7. Results of investigations within the IWGFR benchmark test acoustic boiling noise detection

    International Nuclear Information System (INIS)

    Mauersberger, H.; Froehlich, K.J.

    1989-01-01

    The present paper deals with investigations of acoustic signals from a boiling experiment performed on the KNS I loop at KfK Karlsruhe. Signals have been analysed in frequency as well as in time domain. Signal characteristics successfully used to detect the boiling process have been found in time domain. A proposal for in-service boiling monitoring by acoustic means is briefly described. (author). 10 refs, 16 figs, 1 tab

  8. Preoperative screening: value of previous tests.

    Science.gov (United States)

    Macpherson, D S; Snow, R; Lofgren, R P

    1990-12-15

    To determine the frequency of tests done in the year before elective surgery that might substitute for preoperative screening tests and to determine the frequency of test results that change from a normal value to a value likely to alter perioperative management. Retrospective cohort analysis of computerized laboratory data (complete blood count, sodium, potassium, and creatinine levels, prothrombin time, and partial thromboplastin time). Urban tertiary care Veterans Affairs Hospital. Consecutive sample of 1109 patients who had elective surgery in 1988. At admission, 7549 preoperative tests were done, 47% of which duplicated tests performed in the previous year. Of 3096 previous results that were normal as defined by hospital reference range and done closest to the time of but before admission (median interval, 2 months), 13 (0.4%; 95% CI, 0.2% to 0.7%), repeat values were outside a range considered acceptable for surgery. Most of the abnormalities were predictable from the patient's history, and most were not noted in the medical record. Of 461 previous tests that were abnormal, 78 (17%; CI, 13% to 20%) repeat values at admission were outside a range considered acceptable for surgery (P less than 0.001, frequency of clinically important abnormalities of patients with normal previous results with those with abnormal previous results). Physicians evaluating patients preoperatively could safely substitute the previous test results analyzed in this study for preoperative screening tests if the previous tests are normal and no obvious indication for retesting is present.

  9. Conception of spent fuel and radioactive wastes management in Poland based on the results of the previous work performed in the frames of Governmental Strategic Programme realised under patronate of National Atomic Energy Agency

    International Nuclear Information System (INIS)

    Wlodarski, J.; Chwaszczewski, S.; Slizowski, K.; Frankowski, Z.

    1999-01-01

    About 300 cubic meters of solid and solidified radioactive wastes of low and medium activity are produced each year in Poland. Such materials, after processing, are stored in the Institute of Atomic Energy at Swierk or in the National Repository for Radioactive Wastes in Rozan. About 6000 spent fuel elements are temporarily stored in water pools at Swierk. Assumptions and strategy of future spent fuel and radioactive wastes management are presented taking into account operation of the first nuclear power plants (after 2010). Then Governmental Strategic Programme (GSP) for the year 1997-1999 concerning such topic is described and some results of the work performed in the frames of the GSP are given

  10. Commenting on Research Results in Applied Linguistics and Education: A Comparative Genre-Based Investigation

    Science.gov (United States)

    Lim, Jason Miin-Hwa

    2010-01-01

    As university students are frequently given the tasks of writing research reports to fulfil their respective programme requirements, teaching novice writers to present the results of their reports understandably constitutes an essential component of English lessons at tertiary level. While past research has shown that results are consistently…

  11. Preliminary Results From the CAUGHT Experiment: Investigation of the North Central Andes Subsurface Using Receiver Functions and Ambient Noise Tomography

    Science.gov (United States)

    Ryan, J. C.; Ward, K. M.; Porter, R. C.; Beck, S. L.; Zandt, G.; Wagner, L. S.; Minaya, E.; Tavera, H.

    2011-12-01

    Jamie Ryan, Kevin M. Ward, Ryan Porter, Susan Beck, George Zandt, Lara Wagner, Estela Minaya, and Hernando Tavera The University of Arizona The University of North Carolina San Calixto Observatorio, La Paz, Bolivia IGP, Lima, Peru In order to investigate the interplay between crustal shortening, lithospheric removal, and surface uplift we have deployed 50 broadband seismometers in northwestern Bolivia and southern Peru as part of the interdisciplinary Central Andean Uplift and Geodynamics of High Topography (CAUGHT) project. The morphotectonic units of the central Andes from west to east, consist of the Western Cordillera, the active volcanic arc, the Altiplano, an internally drained basin (~4 km elevation), the Eastern Cordillera, the high peaks (~6 km elevation) of an older fold and thrust belt, the Subandean zone, the lower elevation active fold and thrust belt, and the foreland Beni basin. Between northwestern Bolivia and southern Peru, the Altiplano pinches out north of Lake Titicaca as the Andes narrow northward. The CAUGHT seismic instruments were deployed between 13° to 18° S latitudes to investigate the crust and mantle lithosphere of the central Andes in this transitional zone. In northwest Bolivia, perpendicular to the strike of the Andes, there is a total of 275 km of documented upper crustal shortening (15° to 17°S) (McQuarrie et al, 2008). Associated with the shortening is crustal thickening and possibly lithospheric removal as the thickening lithospheric root becomes unstable. An important first order study is to compare upper crustal shortening estimates with present day crustal thickness. To estimate crustal thickness, we have calculated receiver functions using an iterative deconvolution method and used common conversion point stacking along the same profile as the geologically based shortening estimates. In our preliminary results, we observed a strong P to S conversion corresponding to the Moho at approximately 60-65 km depth underneath the

  12. Forsmark site investigation. Searching for evidence of late- or postglacial faulting in the Forsmark region. Results from 2002-2004

    International Nuclear Information System (INIS)

    Lagerbaeck, Robert; Sundh, Martin; Svedlund, Jan-Olov; Johansson, Helena

    2005-10-01

    currents were responsible for significant erosion of the bed of the ancient sea. Together with sliding, this erosion resulted in extensive redistribution of sediments and in a substantial levelling of the terrain. The discovery of apparently freshly fractured bedrock within the candidate area at Forsmark raised the question of the origin and significance of the features. The spatial and temporal relationships between this fracturing, still more intensely disrupted bedrock exposures and an extreme abundance of glacially transported boulders in the vicinities suggest that a phase of greatly intensified fracturing and quarrying occurred during a late stage of deglaciation. Field evidence clearly indicates that in parts of the investigation area the surficial bedrock, previously protruding bedrock knobs included, were disrupted and transformed into sheets of boulders

  13. Forsmark site investigation. Searching for evidence of late- or postglacial faulting in the Forsmark region. Results from 2002-2004

    Energy Technology Data Exchange (ETDEWEB)

    Lagerbaeck, Robert; Sundh, Martin; Svedlund, Jan-Olov; Johansson, Helena [Geological Survey of Sweden, Uppsala (Sweden)

    2005-10-15

    that strong currents were responsible for significant erosion of the bed of the ancient sea. Together with sliding, this erosion resulted in extensive redistribution of sediments and in a substantial levelling of the terrain. The discovery of apparently freshly fractured bedrock within the candidate area at Forsmark raised the question of the origin and significance of the features. The spatial and temporal relationships between this fracturing, still more intensely disrupted bedrock exposures and an extreme abundance of glacially transported boulders in the vicinities suggest that a phase of greatly intensified fracturing and quarrying occurred during a late stage of deglaciation. Field evidence clearly indicates that in parts of the investigation area the surficial bedrock, previously protruding bedrock knobs included, were disrupted and transformed into sheets of boulders.

  14. results

    Directory of Open Access Journals (Sweden)

    Salabura Piotr

    2017-01-01

    Full Text Available HADES experiment at GSI is the only high precision experiment probing nuclear matter in the beam energy range of a few AGeV. Pion, proton and ion beams are used to study rare dielectron and strangeness probes to diagnose properties of strongly interacting matter in this energy regime. Selected results from p + A and A + A collisions are presented and discussed.

  15. Investigation of Influence of Speech Specter Differences on Intelligibility Estimation Results

    Science.gov (United States)

    Ivanov, A. V.; Reva, I. L.; Shemshetdinova, E. E.

    2018-01-01

    The purpose of this study is to investigate influence of difference of speakers’ speech specters on word intelligibility. Experiment on estimation of speakers’ speech specter difference was conducted with taking into account an effect of a text which a speaker uses. Theoretical calculation of speaker’s speech specter influence on intelligibility was done with use of voice information protection approach. The influence of speaker’s speech specter on intelligibility was confirmed by immediate appreciation tests. Recomendations on possible consideration of the effect are provided.

  16. Principal trends and results of investigations in the field of chemistry of condensed phosphates

    International Nuclear Information System (INIS)

    Tananaev, I.V.; Gruntse, Kh.; Chudinova, N.N.; Akademie der Wissenschaften der DDR, Berlin. Zentralinstitut fuer Anorganische Chemie)

    1984-01-01

    Investigations into the chemistry of condensed phosphates (oligomeric or polymeric phosphorus (5) derivatives, containing POP bonds) jointly performed by the Institute of General and Inorganic Chemistry of the USSR Academy of Sciences and the Central Institute of Inorganic Chemistry of the GDR Academy of Sciences are reviewed. Investigations followed two trends: 1) development of scientific grounds for the synthesis of phosphate polymers (studying the mechanism of crystallization, condensation and polymerization reactions in the phosphate systems); 2) preparing phosphates of various compositions and structure (cyclic, branched and chain structure of anions), jnvestigating their structure and properties, establishing correlations between the composition, structure and properties for directed synthesis of compounds with definite properties. Phosphates of Al, Ga, In, rare earths, Cr, Bi, Zn, Cd, Ti, Ge, Zr, Hf, Th, V, Nb, Ta, Mo, W, U, Mn, Fe, Co, Ni are considered as well as binary phosphates with alakali metals. The studied inorganic polymers exhibited a wide range of properties which seem to be promising for their use in various fields of technology

  17. Deep brain stimulation results in local glutamate and adenosine release: investigation into the role of astrocytes.

    Science.gov (United States)

    Tawfik, Vivianne L; Chang, Su-Youne; Hitti, Frederick L; Roberts, David W; Leiter, James C; Jovanovic, Svetlana; Lee, Kendall H

    2010-08-01

    Several neurological disorders are treated with deep brain stimulation; however, the mechanism underlying its ability to abolish oscillatory phenomena associated with diseases as diverse as Parkinson's disease and epilepsy remain largely unknown. To investigate the role of specific neurotransmitters in deep brain stimulation and determine the role of non-neuronal cells in its mechanism of action. We used the ferret thalamic slice preparation in vitro, which exhibits spontaneous spindle oscillations, to determine the effect of high-frequency stimulation on neurotransmitter release. We then performed experiments using an in vitro astrocyte culture to investigate the role of glial transmitter release in high-frequency stimulation-mediated abolishment of spindle oscillations. In this series of experiments, we demonstrated that glutamate and adenosine release in ferret slices was able to abolish spontaneous spindle oscillations. The glutamate release was still evoked in the presence of the Na channel blocker tetrodotoxin, but was eliminated with the vesicular H-ATPase inhibitor bafilomycin and the calcium chelator 2-bis(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid tetrakis acetoxymethyl ester. Furthermore, electrical stimulation of purified primary astrocytic cultures was able to evoke intracellular calcium transients and glutamate release, and bath application of 2-bis (2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid tetrakis acetoxymethyl ester inhibited glutamate release in this setting. Vesicular astrocytic neurotransmitter release may be an important mechanism by which deep brain stimulation is able to achieve clinical benefits.

  18. Criminal anticipation of DNA investigations resulting in mutilation of a corpse.

    Science.gov (United States)

    Karger, B; Rand, S P; Brinkmann, B

    2000-01-01

    A corpse of a female was found in her apartment in a state of advanced putrefaction. Both hands were amputated, the external genitals were excised and the body parts had been removed from the scene. The subsequent investigations proved that the body parts had been severed post mortem. The cause of death was determined to be manual strangulation. A 33-year-old man later confessed that he had strangled the victim 9 days prior to discovery of the body and that he had had sexual intercourse post mortem. According to the confession, the rational motive for the subsequent mutilation was to eliminate biological stains (e.g. semen inside the vagina, epithelial cells below the fingernails from scratching) suitable for forensic DNA analysis. This constitutes a new type of defensive mutilation intended to prevent the identification of the perpetrator. An increase in the occurrence would be detrimental to the elucidation rate of homicides: in a total of 171 homicides investigated at this institute, DNA analysis of biological stains gave reliable evidence in 45 cases.

  19. Evaluation of clinical and biological prognostic factors in relapsed or refractory diffuse large B-cell lymphoma patients after previous treatment with rituximab and chemotherapy: results of the PRO-R-IPI study.

    Science.gov (United States)

    Panizo, Carlos; Rodríguez, Anny Jaramillo; Gutiérrez, Gonzalo; Díaz, Francisco Javier; González-Barca, Eva; de Oña, Raquel; Grande, Carlos; Sancho, Juan Manuel; García-Álvarez, María Flor; Sánchez-González, Blanca; Peñalver, Francisco Javier; Cannata, Jimena; Espeso, Manuel; Requena, María José; Gardella, Santiago; Durán, Soledad; González, Ana Pilar; Alfonso, Ana; Caballero, María Dolores

    2015-07-01

    Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity, showing a highly variable outcome. In patients with DLBCL relapsed/refractory to first-line treatment with rituximab the usefulness of the revised International Prognostic Index (R-IPI) as a prognostic tool remains unexplored. Some biological parameters (B-cell lymphoma 6 [Bcl-6], Bcl-2, p53, and multiple myeloma 1 [MUM1]) and blood populations (lymphocyte and monocyte counts) have been described as International Prognostic Index-independent prognostic factors. The objective was to evaluate the R-IPI to predict the outcome of DLBCL patients at the time of relapse after a front-line treatment with chemotherapy and rituximab and to establish in this population the relationship between biological parameters and outcome. We included patients with refractory/relapsed DLBCL after first-line treatment with rituximab-containing regimens; patients must have already finished a rescue treatment also including rituximab. Immunohistochemical assessment of Bcl-2, Bcl-6, p53, and MUM1 expression were undertaken in available biopsies. R-IPI factors were identified from the clinical data at diagnosis and at relapse. Response was assessed using National Cancer Institute-sponsored Working Group guidelines. R-IPI prognosis at relapse was not significantly associated with overall response rate (ORR) after Rituximab-chemotherapy rescue therapy. None of the immunohistochemical parameters analyzed correlated with rescue therapy results. In contrast, patients with absolute lymphocyte count (ALC) ≥ 1 × 10(9)/L at relapse were more likely to respond than patients with ALC IPI score calculated at relapse could not predict the ORR to second-line treatment. Lymphopenia is a simple and useful predictor for outcome in relapsed/refractory DLBCL and the only prognostic factor that in our hands could predict the overall response to a second-line treatment with rituximab and chemotherapy. Copyright © 2015 Elsevier Inc. All rights

  20. Results from Nevada Nuclear Waste Storage Investigations (NNWSI) Series 3 spent fuel dissolution tests

    International Nuclear Information System (INIS)

    Wilson, C.N.

    1990-06-01

    The dissolution and radionuclide release behavior of spent fuel in groundwater is being studied by the Yucca Mountain Project (YMP), formerly the Nevada Nuclear Waste Storage Investigations (NNWSI) Project. Specimens prepared from pressurized water reactor fuel rod segments were tested in sealed stainless steel vessels in Nevada Test Site J-13 well water at 85 degree C and 25 degree C. The test matrix included three specimens of bare-fuel particles plus cladding hulls, two fuel rod segments with artificially defected cladding and water-tight end fittings, and an undefected fuel rod section with watertight end fittings. Periodic solution samples were taken during test cycles with the sample volumes replenished with fresh J-13 water. Test cycles were periodically terminated and the specimens restarted in fresh J-13 water. The specimens were run for three cycles for a total test duration of 15 months. 22 refs., 32 figs., 26 tabs

  1. CEM V based special cementitious materials investigated by means of SANS method. Preliminary results

    Science.gov (United States)

    Dragolici, A. C.; Balasoiu, M.; Orelovich, O. L.; Ionascu, L.; Nicu, M.; Soloviov, D. V.; Kuklin, A. I.; Lizunov, E. I.; Dragolici, F.

    2017-05-01

    The management of the radioactive waste assume the conditioning in a cement matrix as an embedding, stable, disposal material. Cement matrix is the first and most important engineering barrier against the migration in the environment of the radionuclides contained in the waste packages. Knowing how the microstructure develops is therefore desirable in order to assess the compatibility of radioactive streams with cement and predict waste form performance during storage and disposal. For conditioning wastes containing radioactive aluminum new formulas of low basicity cements, using coatings as a barrier between the metal and the conditioning environment or introducing a corrosion inhibitor in the matrix system are required. Preliminary microstructure investigation of such improved CEM V based cement matrix is reported.

  2. Project Morpheus: Morpheus 1.5A Lander Failure Investigation Results

    Science.gov (United States)

    Devolites, Jennifer L.; Olansen, Jon B.; Munday, Stephen R.

    2013-01-01

    On August 9, 2012 the Morpheus 1.5A vehicle crashed shortly after lift off from the Kennedy Space Center. The loss was limited to the vehicle itself which was pre-declared to be a test failure and not a mishap. The Morpheus project is demonstrating advanced technologies for in space and planetary surface vehicles including: autonomous flight control, landing site hazard identification and safe site selection, relative surface and hazard navigation, precision landing, modular reusable flight software, and high performance, non-toxic, cryogenic liquid Oxygen and liquid Methane integrated main engine and attitude control propulsion system. A comprehensive failure investigation isolated the fault to the Inertial Measurement Unit (IMU) data path to the flight computer. Several improvements have been identified and implemented for the 1.5B and 1.5C vehicles.

  3. Tuberculosis in alpaca (lama pacos on a farm in ireland. 2. results of an epidemiological investigation

    Directory of Open Access Journals (Sweden)

    Connolly DJ

    2008-08-01

    Full Text Available Abstract Tuberculosis (TB, due to infection with Mycobacterium bovis was diagnosed in a flock of alpaca in Ireland in 2004. An epidemiological investigation was conducted to identify the risk of TB for farmed alpaca where TB is endemic, the origin of the infection, the potential for alpaca-to-alpaca transmission and appropriate control measures. The investigation focused on the alpaca flock (including the farm, animal movements and breeding, feeding and flock health practice, the disease episode (including animal disease events and subsequent control measures and TB infection risk in the locality. The TB risk to alpaca is high in areas where infection is endemic in cattle and badgers and where biosecurity is inadequate. It is most likely that the source of infection for the alpaca was a local strain of M. bovis, present in cattle in this area since at least 2001. Genotyping of isolates identified a single variable number tandem repeat (VNTR profile in both cattle and alpaca in this region. Although a tuberculous badger was also removed from the vicinity, bacterial isolation was not attempted. On this farm, infection in alpaca was probably derived from a common source. Alpaca-to-alpaca transmission seems unlikely. Two broad control strategies were implemented, aimed at the rapid removal of infected (and potentially infectious animals and the implementation of measures to limit transmission. Tests that proved useful in detecting potentially-infected animals included measurement of the albumin-to-globulin ratio and regular body condition scoring. Skin testing was time consuming and unproductive, and early detection of infected animals remains a challenge. The flock was managed as a series of separate groupings, based on perceived infection risk. No further TB cases have been detected.

  4. INVESTIGATIONS TO IMPROVE THE TRANSFERABILITY OF SPECIMEN RESULTS BY REAL COMPONENT

    Directory of Open Access Journals (Sweden)

    Martin Riedler

    2010-12-01

    Full Text Available For the improvement of the lifetime calculation of components made of the titanium alloy Ti-6-4, a closed loop methodology from specimen to the component is presented. Based on forged pre-material specimens fatigue tests are done as a basic research, which are presented as S/N-curves. With the determined material data a lifetime calculation with the program FEMFAT is done on a typically fitting element. Finally the results of the lifetime calculation are compared to real component tests, which are done to evaluate the results of the lifetime calculation. The component tests are performed with constant and variable load. Therewith the transferability of specimen results to real components is shown. Additional fracture analysis by light microscope and scanning electron microscope is carried out to give further information of the influence factor of the lifetime and a further description between fracture behaviour of specimen and components.

  5. Investigation of user needs for driver assistance: results of an Internet questionnaire

    NARCIS (Netherlands)

    van Driel, Cornelie; van Arem, Bart

    2005-01-01

    Advanced Driver Assistance Systems (ADAS) aim at supporting the driver with the driving task and are expected to lead to a safer, cleaner and more efficient and comfortable transport system. This paper presents the results of an Internet questionnaire among more than 1000 Dutch car drivers.

  6. Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition.

    Science.gov (United States)

    Brand, J S; Onland-Moret, N C; Eijkemans, M J C; Tjønneland, A; Roswall, N; Overvad, K; Fagherazzi, G; Clavel-Chapelon, F; Dossus, L; Lukanova, A; Grote, V; Bergmann, M M; Boeing, H; Trichopoulou, A; Tzivoglou, M; Trichopoulos, D; Grioni, S; Mattiello, A; Masala, G; Tumino, R; Vineis, P; Bueno-de-Mesquita, H B; Weiderpass, E; Redondo, M L; Sánchez, M J; Castaño, J M Huerta; Arriola, L; Ardanaz, E; Duell, E J; Rolandsson, O; Franks, P W; Butt, S; Nilsson, P; Khaw, K T; Wareham, N; Travis, R; Romieu, I; Gunter, M J; Riboli, E; van der Schouw, Y T

    2015-06-01

    Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000. Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale. Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89-1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10-20 years: HR = 1.43; 95% CI 1.02-2.01, France); German Cancer Aid, German Cancer Research Center (DKFZ) and Federal Ministry of Education and Research (BMMF) (Germany); Ministry of Health and Social Solidarity, Stavros Niarchos Foundation and Hellenic Health Foundation (Greece); Italian Association for Research on Cancer (AIRC) and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), Regional Governments of Andaluc

  7. Investigation of Bearing Axial Cracking: Benchtop and Full-Scale Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gould, Benjamin [Argonne National Lab. (ANL), Argonne, IL (United States); Greco, Aaron [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-08-16

    The most common failure mode in wind turbine gearboxes is axial cracking in intermediate and high-speed-stage bearings, also commonly called white-etching cracks (WECs). Although these types of cracks have been reported for over a decade, the conditions leading to WECs, the process by which this failure culminates, and the reasons for their apparent prevalence in wind turbine gearboxes are all highly debated. This paper summarizes the state of a multipronged research effort to examine the causes of WECs in wind turbine gearbox bearings. Recent efforts have recreated WECs on a benchtop test rig in highly loaded sliding conditions, wherein it was found that the formation of a dark etching microstructure precedes the formation of a crack, and a crack precedes the formation of white-etching microstructure. A cumulative frictional sliding energy criterion has been postulated to predict the presence of WECs. Bearing loads have also been measured and predicted in steady state and transient drivetrain operations in dynamometer testing. In addition, both loads and sliding at full scale will be measured in planned uptower drivetrain testing. If the cumulative frictional sliding energy is the dominant mechanism that causes WECs, understanding the amount of frictional sliding energy that wind turbine bearings are subjected to in typical operations is the next step in the investigation. If highly loaded sliding conditions are found uptower, similar to the examined benchtop levels, appropriate mitigation solutions can be examined, ranging from new bearing coatings and improved lubricants to changes in gearbox designs and turbine operations.

  8. Further efforts needed to achieve measles elimination in Germany: results of an outbreak investigation

    Science.gov (United States)

    Siedler, Anette; Sagebiel, Daniel; Hellenbrand, Wiebke; Santibanez, Sabine; Mankertz, Annette; Vogt, Georg; van Treeck, Ulrich; Krause, Gérard

    2009-01-01

    Abstract Objective To determine morbidity and costs related to a large measles outbreak in Germany and to identify ways to improve the country’s national measles elimination strategy. Methods We investigated a large outbreak of measles in the federal state of North Rhine-Westphalia (NRW) that occurred in 2006 after 2 years of low measles incidence (complications, hospitalization and physician consultations. Findings In NRW, 1749 cases were notified over a 48-week period. Compared with 2001, the distribution of cases shifted to older age groups (especially the 10–14 year group). Most cases (n = 614) occurred in Duisburg. Of these, 81% were interviewed; 15% were hospitalized and two died. Of the 464 for whom information was available, 80% were reported as unvaccinated. Common reasons for non-vaccination were parents either forgetting (36%) or rejecting (28%) vaccination. The average cost per measles case was estimated at €373. Conclusion An accumulation of non-immune individuals led to this outbreak. The shift in age distribution has implications for the effectiveness of measles control and the elimination strategy in place. Immediate nationwide school-based catch-up vaccination campaigns targeting older age groups are needed to close critical immunity gaps. Otherwise, the elimination of measles in Germany and thus in Europe by 2010 will not be feasible. PMID:19274362

  9. Does indirect speech promote nondirective genetic counseling? Results of a sociolinguistic investigation.

    Science.gov (United States)

    Benkendorf, J L; Prince, M B; Rose, M A; De Fina, A; Hamilton, H E

    2001-01-01

    To date, research examining adherence to genetic counseling principles has focused on specific counseling activities such as the giving or withholding of information and responding to client requests for advice. We audiotaped 43 prenatal genetic counseling sessions and used data-driven, qualitative, sociolinguistic methodologies to investigate how language choices facilitate or hinder the counseling process. Transcripts of each session were prepared for sociolinguistic analysis of the emergent discourse that included studying conversational style, speaker-listener symmetry, directness, and other interactional patterns. Analysis of our data demonstrates that: 1) indirect speech, marked by the use of hints, hedges, and other politeness strategies, facilitates rapport and mitigates the tension between a client-centered relationship and a counselor-driven agenda; 2) direct speech, or speaking literally, is an effective strategy for providing information and education; and 3) confusion exists between the use of indirect speech and the intent to provide nondirective counseling, especially when facilitating client decision-making. Indirect responses to client questions, such as those that include the phrases "some people" or "most people," helped to maintain counselor neutrality; however, this well-intended indirectness, used to preserve client autonomy, may have obstructed direct explorations of client needs. We argue that the genetic counseling process requires increased flexibility in the use of direct and indirect speech and provide new insights into how "talk" affects the work of genetic counselors.

  10. Results of investigations at the Zunil geothermal field, Guatemala: Well logging and brine geochemistry

    Energy Technology Data Exchange (ETDEWEB)

    Adams, A.; Dennis, B.; Van Eeckhout, E.; Goff, F.; Lawton, R.; Trujillo, P.E.; Counce, D.; Archuleta, J. (Los Alamos National Lab., NM (USA)); Medina, V. (Instituto Nacional de Electrificacion, Guatemala City (Guatemala). Unidad de Desarollo Geotermico)

    1991-07-01

    The well logging team from Los Alamos and its counterpart from Central America were tasked to investigate the condition of four producing geothermal wells in the Zunil Geothermal Field. The information obtained would be used to help evaluate the Zunil geothermal reservoir in terms of possible additional drilling and future power plant design. The field activities focused on downhole measurements in four production wells (ZCQ-3, ZCQ-4, ZCQ-5, and ZCQ-6). The teams took measurements of the wells in both static (shut-in) and flowing conditions, using the high-temperature well logging tools developed at Los Alamos National Laboratory. Two well logging missions were conducted in the Zunil field. In October 1988 measurements were made in well ZCQ-3, ZCQ-5, and ZCQ-6. In December 1989 the second field operation logged ZCQ-4 and repeated logs in ZCQ-3. Both field operations included not only well logging but the collecting of numerous fluid samples from both thermal and nonthermal waters. 18 refs., 22 figs., 7 tabs.

  11. Experimental Investigation of the Vehicle–Ground Interaction – Experiment Preparation and Preliminary Results

    Directory of Open Access Journals (Sweden)

    Valašková Veronika

    2017-12-01

    Full Text Available Interaction of the moving vehicle and the ground represents the actual engineering, environmental and economic problem. Due to the complexity of the problem, a combination of the experimental measurement and the computational simulation to understand the interaction mechanism is the most beneficial approach. Results of the in-situ observation serve as an input for the numerical analysis and also as a background for the calibration of the model. Presented paper brings the summary of the experiment preparation and preliminary results which are necessary for further analyses and numerical models. Computational simulations will be helpful for understanding the vehicle-ground interaction when inputs will be verified by the experimental way at known boundary conditions.

  12. Assessment of the value of electricity grids - Results of an investigation using enterprise data

    International Nuclear Information System (INIS)

    Schaerer, M.; Kaufmann, I.; Flury, R.

    2002-01-01

    This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study made on the effects of different ways of evaluating the transmission fees for the use of electricity grids as foreseen in Swiss legislation on electricity market liberalisation. The study was made using enterprise data supplied by various distribution utilities. The sensitivity analysis made, with the capital costs of the grids as its kernel, is described. Four variants based on different combinations of basic assessment data and rates of interest are presented. The availability and quality of data is discussed, as is the large number of different utility types to be found in Switzerland. For the interpretation of the results of the study, two primary points of view are considered - that of the utility, focussed on future investments and their financing, and that of the consumer, focussed on pricing aspects. The report is concluded with recommendations on which models should be proposed for a future electricity market decree

  13. Investigation of radio objects with continuos optical spectra. The results of four-color electrophotometric observations

    International Nuclear Information System (INIS)

    Beskin, G.M.; Lyutyj, V.M.; Neizvestnyj, S.I.; Pustil'nik, S.I.; Shvartsman, V.F.

    1985-01-01

    The results of UBVR photometry of 30 radio objects with continuous optical spectra (ROCOSes) are reported. The observations were performed using five telescopes during the years 1979-1982; 54 values have been obtained of U, B, V magnitudes and 26 ones of R magnitude. Colours for 16 ROCOSes have been obtained for the first time. The analysis of the data results in the following conclusions. 1) Practically all colours of ROCOSes have proved to be in the region of localization of BL Lac objects' colours on UBV and BVR diagrams. This fact (altogether with the other data) indicates on the proximity of the objects of the two classes. 2) In half of all cases, instantaneous colours of ROCOSes corresponded to purely power-law optical continua F(ν) varies as νsup(α) with α approximately= -(1-2.5). 3) In the remaining cases, optical continua differed significantly from the power-law ones. 4) 6 ROCOSes appeared to be in the phases of deep minimum of brightness at the moment of observations (namely, about 3sup(m)-5sup(m) fainter than in the brightest phase known from the literature). The UBVR colours of none of them give indication on the presence of an elliptical galaxy which, according to conventional concepts, must encompass a variable nonthermal source. 5) Two blue objects, 0548+165 and 0713+199, which are situated at low galactic latitudes (b 2 =-5 deg and +14 deg respectively) have shown colours unusual for lacertids. Appendices contain the results of theoretical calculations of (U-B), (B-V) and (V-R) colours for purely power-law spectra F(ν)=constxνsup(α) with α in the range (-6.5-+2.5) and the results of UBV photometry of the BL Lac object OJ 287 during the years 1976-1982 (24 measurements)

  14. The Results of Experimental Investigation Recycling Meat and Plant Waste in the Periodic Operation Bioreactor

    Directory of Open Access Journals (Sweden)

    Antonas Misevičius

    2011-12-01

    Full Text Available Waste is unwanted materials that are mainly the result of human activities and one of the sources of environmental pollution. An increase in the world’s population causes a growth in the amounts of waste in the modern world. Every year, the increasing quantities of waste are the major problems these days; therefore, calls for taking effective measures to tackle this problem could be effective tools. The article presents the results of experimental studies on using meat waste and their mixes with herbal waste. The conducted experiments observed the concentrations of methane, hydrogen sulphide and oxygen under periodic mesophilic conditions in the bioreactor. Research has shown that the use of herbal supplements with meat waste produces better results than using only meat waste. The digestion of meat wastes points to an average amount of biogas which is 0.5 m3/m3d, that of meat and herbal waste mixture (19:1 – 0.51 m3/m3d, meat and herbal waste mixture (9:1 – 0.56 m3/m3d. The content of biogas methane was 0.074 m3/m3d, 0.083 m3/m3d, 0.101 m3/m3d respectively.Article in Lithuanian

  15. Preliminary results of ERTS-investigations by W-German investigations. [multidisciplinary geoscientific experiments in central Germany and hydrogeology of Argentina Pampas

    Science.gov (United States)

    Muehlfeld, R.

    1974-01-01

    Results are presented of West German investigations into multidisciplinary geoscientific experiments in central Germany and the Alps, and hydrogeological investigations in the Pampa of Argentina based on ERTS-1 data. The main goals of the investigation were achieved. The studies have given a good idea of the possibilities and limitations of ERTS imagery depending on the objectives in question and on the geographical conditions of the areas under investigation. Even in the well known region of central Europe, ERTS has proven its ability of improving present knowledge. In fields such as pollution monitoring and regional planning the satellite techniques should have distinct practical value. For any regional study of less known areas, the value of ERTS imagery can hardly be overestimated.

  16. Safety and effectiveness of a 6-French MRI conditional pacemaker lead: The INGEVITYTMclinical investigation study results.

    Science.gov (United States)

    Nielsen, Jens C; Giudici, Michael; Tolasana Viu, Jose Maria; Chew, Engwooi; Sommerijns, Elke; Wold, Nicholas; Evert, Linda; Love, Charles J; Stein, Kenneth; Olaf, Hedrich

    2017-10-01

    The design of pacemaker leads has continued to evolve; ease of lead handling, improved electrical performance, and magnetic resonance imaging (MRI) conditional aspects have become more important, while safety remains critical. The INGEVITY™ family leads was designed to provide MRI conditional aspects, decreased diameter, and improved performance of pacemaker leads. The INGEVITY study is an investigational device exemption trial evaluating the acute and chronic safety and effectiveness of these leads. Consecutive patients were included in 77 institutions worldwide, where 1,657 leads (846 right ventricular active fixation leads, 213 right ventricular passive fixation leads, 121 right atrial passive fixation preformed J-leads, and 477 right atrial active fixation leads) were implanted or attempted in 1,060 subjects. At 3-month follow-up, the electrical performance were: mean pacing threshold 0.67 V at 0.5-ms pulse width, pacing impedance 773 ohms, mean P-wave amplitude 4.8 mV, and R-wave amplitude 16.5 ± 6.5 mV. Over a median follow-up of 31 months, 93 subjects died and 33 subjects reported lead-related complications. Lead-related complication-free rate from 0 to 3 months and 3 to 12 months for all leads was 98.4% and 99.7%, respectively. The hazard of lead-related complications was observed to be decelerating over the course of follow-up (Weibull shape = 0.23). The overall lead dislodgment rate observed in the study was 1.3%, the perforation rate was 0.0%, and the pericardial effusion rate was 0.3%. The clinical performance of the INGEVITY lead demonstrated a high lead-related complication-free rate over 12 months of follow-up and excellent electrical characteristics. © 2017 Wiley Periodicals, Inc.

  17. Investigation Results on Solar Array Thermal & Electrical Imbalance Phenomenon on Power Systems Equipped with MPPT

    Science.gov (United States)

    Mercier, F.; Samaniego, B.; Soriano, T.; Beaufils, G.; Fernandez Lisbona, E.; Dettlaff, K.; Jensen, H.

    2014-08-01

    The thermal / electrical imbalance phenomenon on the satellite solar arrays is a common issue inherent to the negative thermal voltage coefficient of the triple junction cells, which is usually already taken into account with basic precautions on the solar panel layout.In the frame of the ESA TRP study "Investigation on Solar Array thermal and electrical imbalance phenomenon on power systems equipped with Maximum Power Point Tracker (MPPT)" performed by Airbus Defence & Space (former Astrium Toulouse and Ottobrunn) and TERMA, in-depth analyses were conducted for the first time to better understand and characterize the secondary maximum power point phenomenon for various representative mission cases, whether in Earth vicinity or not. With the help of a newly developed detailed thermo-electrical coupled solver and a wide range of solar cell characterizations in flux and temperature, multiple sets of simulations were run to simulate realistic solar panel characteristics.The study showed that no secondary false maximum power point can be created on the solar panel characteristic IV curve for missions around Earth vicinity, at the sole exception of critical shadowing cases. Furthermore, the same conclusions apply for missions up to Mars orbit. The only potential threats come from the missions further than Mars (typically Jupiter missions) where various very high heterogeneities could lead to multiple maxima. This is deeply linked to the LILT (low illumination low temperature) conditions applied to the current solar cell triple junction characteristics and shape. Moreover, thermo-electrical imbalances that do not create secondary power point can still seriously grieve the solar array power output performances. This power loss can however be accurately assessed by the newly developed solver in support of in-development missions like Juice.

  18. Neutron activation investigation of the accumulation of some elements in Taraxacum officinale, resulting from environmental pollution

    International Nuclear Information System (INIS)

    Kulev, I.; Dzhingova, R.

    1985-01-01

    Taraxinum officinale (dandelion) have been proposed as a biological monitor of antropogenic toxic metals. The INAA has been used to determine the content of As, Cd, Co, Cr, Hg, Mn, Sb, Se, Zn, and atomic absorption spectroscopy - of Cu and Pb in leaf samples collected round a smelter, in a living quarter of a big city and high up in Rila mountains. A logarithmic dependence of the concentration of the elements on the distance from the emitter was found. The results have shown that the leaves of Taraxacum Officinale reflect the level of environmental pollution thus beeing a very suitable bioindicator for local pollution

  19. Preliminary Results on the Experimental Investigation of the Structure Functions of Bound Nucleons

    Energy Technology Data Exchange (ETDEWEB)

    Bodek, Arie [Univ. of Rochester, NY (United States); Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-08-01

    We present preliminary results on an experimental study of the nuclear modification of the longitudinal ($\\sigma_L$) and transverse ($\\sigma_T$) structure functions of nucleons bound in nuclear targets. The origin of these modifications (commonly referred as as the EMC effect) is not fully understood. Our measurements of R= $\\sigma_L / \\sigma_T$ for nuclei ($R_A$) and for deuterium ($R_D$) indicate that nuclear modifications of the structure functions of bound nucleons are different for the longitudinal and transverse structure functions, and that contrary to expectation from several theoretical models, $R_A< R_D$.

  20. [Results of intelligence investigations in civil pilots with atherosclerotic changes in cerebral vessels].

    Science.gov (United States)

    Razsolov, N A; Krapivnitskaia, T A; Khashba, B G

    2009-01-01

    Intelligence was evaluated in 73 normal civil pilots (control) and 70 with atherosclerotic cerebral vessels including 23 men with atheromas. Intelligence was evaluated with the use of computerized EPI (Gorbov's modification). Pilots with cerebral atherosclerosis tended to slightly decrease mean IQ values in comparison with the normal; IQ values remained high enough to attest professional efficiency. Atheromas did not impact results of the numerical (IQ2) and verbal (IQ3) tests. Hemodynamically negligible stable atheromas did not disturb cognitive functions of the pilots and, therefore, they were certified for continuation of the flight career.

  1. RESULTS OF INVESTIGATIONS ON THERMAL CHARACTERISTICS OF AIR HEATER BUNDLE MADE OF BIMETALLIC FINNED TUBES

    Directory of Open Access Journals (Sweden)

    V. B. Kuntysh

    2014-01-01

    Full Text Available The paper presents a scheme and description of a new aerodynamic stand that has a 300x300 mm cross-section operating channel. The stand is used for studying thermal and aerodynamic characteristics of bundles made of finned tubes of actual dimensions in crossflow. The paper provides results of an exploratory test pertaining to heat transfer and resistance of four row staggered bundle made of tubes with aluminium spiral fins having outside diameter of 26 mm which are used in the systems of ventilation, air-conditioning and heating of buildings and also in transport heat exchangers.

  2. Analysis of Systems Hardware Flown on LDEF-Results of the Systems Special Investigation Group

    Science.gov (United States)

    1992-04-01

    resulted in the development of internal pressures which caused bulging of the NiCd cell cases. However, post-flight testing showed that the battery still...meteoroid impact DAC: bit 25 latched high NiCd battery cells bulging (may have been overcharged). TABLE 4.2-2 ’. Known Electrical Component...Failures PART Part Number MFG. EXP. Relay, Latching FL11D P&B A0038 Capacitor , Tantalum 137D, 33uF Sprague A0187-1 Indicator, Miniature BHGD21T Minelco

  3. Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.

    Science.gov (United States)

    Skudlarek, Jason W; DiMarco, Christina N; Babaoglu, Kerim; Roecker, Anthony J; Bruno, Joseph G; Pausch, Mark A; O'Brien, Julie A; Cabalu, Tamara D; Stevens, Joanne; Brunner, Joseph; Tannenbaum, Pamela L; Wuelfing, W Peter; Garson, Susan L; Fox, Steven V; Savitz, Alan T; Harrell, Charles M; Gotter, Anthony L; Winrow, Christopher J; Renger, John J; Kuduk, Scott D; Coleman, Paul J

    2017-03-15

    In an ongoing effort to explore the use of orexin receptor antagonists for the treatment of insomnia, dual orexin receptor antagonists (DORAs) were structurally modified, resulting in compounds selective for the OX 2 R subtype and culminating in the discovery of 23, a highly potent, OX 2 R-selective molecule that exhibited a promising in vivo profile. Further structural modification led to an unexpected restoration of OX 1 R antagonism. Herein, these changes are discussed and a rationale for selectivity based on computational modeling is proposed. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Results of investigations of non-specific humoral-type response in workers exposed to beryllium

    International Nuclear Information System (INIS)

    Cianciara, M.; Loch, T.

    1989-12-01

    In the group of 30 workers exposed to beryllium a statistically significant increase in the level of immunoglobulins of class A was found in comparison with the control group (p<0.01). This may be an early indicator of a process taking place in the respiratory system. Results of measurement of immunoglobulins, as non-specific indicators, are of limited value in the evaluation of the influence of the occupational factor; at the same time they point to the usefulness of testing for the specific indicators of humoral reactivity in persons whose work involves contact with beryllium or its compounds. (author)

  5. Qualitative and quantitative methods for human factor analysis and assessment in NPP. Investigations and results

    International Nuclear Information System (INIS)

    Hristova, R.; Kalchev, B.; Atanasov, D.

    2005-01-01

    We consider here two basic groups of methods for analysis and assessment of the human factor in the NPP area and give some results from performed analyses as well. The human factor is the human interaction with the design equipment, with the working environment and takes into account the human capabilities and limits. In the frame of the qualitative methods for analysis of the human factor are considered concepts and structural methods for classifying of the information, connected with the human factor. Emphasize is given to the HPES method for human factor analysis in NPP. Methods for quantitative assessment of the human reliability are considered. These methods allow assigning of probabilities to the elements of the already structured information about human performance. This part includes overview of classical methods for human reliability assessment (HRA, THERP), and methods taking into account specific information about human capabilities and limits and about the man-machine interface (CHR, HEART, ATHEANA). Quantitative and qualitative results concerning human factor influence in the initiating events occurrences in the Kozloduy NPP are presented. (authors)

  6. Investigation of personnel beta and gamma dosimetry results at Amok Ltd, Cluff Lake

    International Nuclear Information System (INIS)

    Utting, R.E.; Brown, L.D.; Bradley, R.P.

    1981-06-01

    Apparent skin doses significantly higher than expected have been indicated by some thermoluminescent dosimeters worn by employees at Amok Ltd., Cluff Lake. Calculations have indicated that skin doses as a result of exposure to uranium ore are likely to be no more than twice the whole body doses. Experiments were conducted to expose TL dosimeters to a variety of radioactive materials commonly found in the mill environment under different conditions. The results of these experiments togethr with a re-examination of the original dosimeters leads to the conclusion that contamination either on or inside the dosimeter badge was the cause of the abnormal apparent skin doses. It is therefore recommended that for individuals with apparent skin doses in excess of twice the body dose, the actual skin dose should be considered to be equal to twice the body dose for purposes of determining compliance with the AEC Regulations. It is further recommended that the National Dose Registry records of anomalous skin doses to Amok employees be amended to reflect this. (author)

  7. Incremental versus Rapid Internationalisation of Firms: Results of Exploratory Investigation from Poland

    Directory of Open Access Journals (Sweden)

    Krzysztof Wach

    2016-02-01

    Full Text Available Objective: The main objective of the article was to discuss the pace of internationalisation and its empirical verification among Polish firms taking into account two factors – strategic thinking and familiness of the studied firms. Research Design & Methods: The paper, apart from literature review and its critique, is based on results of a survey conducted among randomly selected 355 internationalised firms of different sizes from Poland. Findings: Firms having an internationalisation strategy rather internationalize faster than these lacking such a strategy, taking into account the average number of years elapses from its founding to the first internationalisation. The empirical results show that the average time of internationalisation is shorter in case of family firms than non-family firms. Implications & Recommendations: Strategic thinking seems to be very important while going international. A well thought-out strategy can stimulate the whole process of internationalisation, so decision makers, especially entrepreneurs, should pay more attention to strategic aspects, even in early stages of development or early internationalisation. Contribution & Value Added: The article attempts to enrich the ongoing scientific discourse on the role of time and the pace of internationalisation by adding some evidence from Poland illustrating and verifying the links between strategic thinking as well as familiness of firms and the speed of internationalisation measured in years from the establishment of firms.

  8. Low-Temperature Thermochronology Investigation in Uruguay and Southernmost Brazil: Apatite (U-Th)/He Results

    Science.gov (United States)

    Machado, J. P.; Bicca, M. M.

    2017-12-01

    Low-temperature thermochronology has successfully allowed one to reveal exhumation histories of many orogenic belts across the Earth, and lately these techniques have been applied in cratonic regions. The present study aims to constrain thermal history and exhumation of the South Atlantic Passive Margin, between Uruguay and Southernmost Brazil, a region scarce of thermochronological data. This location has become relatively stable after the Neoproterozoic Brasiliano Orogeny, being more intensely disturbed by tectonics during the Gondwana Breakup and consequent opening of the Atlantic Ocean (Jurassic - Cretaceous). Both apatite and zircon (U-Th)/He methods are being applied on basement rocks, and since those have a long cooling history, radiation damage is expected to play an important role in crystal ages. A total of 25 samples were analyzed, and preliminary apatite (U-Th)/He results reveals unweighted sample ages ranging from Permian to Lower-Cretaceous in Southernmost Brazil, with a couple of outliers with Devonian - Carboniferous ages. In Uruguay results can be grouped in two different clusters: one of samples with Jurassic to Lower-Cretaceous ages, and another of Devonian to Permian ages. This wide range of results can be assign to variations in the uranium content of the grains, due the presence of inclusions, compositional zonation or substantial radiation damage of the crystalline lattice. In most cases, ages tend to increase with crystal eU content. No clear relationship between ages and tectonic terranes has been found so far, neither between ages and elevation, since the region does not have significant topographic variations. Younger ages are commonly found closer to the coastal region, possibly in response to the rift shoulders uplift during Gondwana breakup and further exhumation and denudation at higher rates. An anomalous concentration of older ages in the southern region of the Pelotas Batholith, close to the Brazil - Uruguay border, suggests a

  9. Initial results from the ISEE-1 and -2 plasma wave investigation

    International Nuclear Information System (INIS)

    Gurnett, D.A.; Anderson, R.R.; Smith, E.J.

    1979-01-01

    In this paper the authors present an initial survey of results from the plasma wave experiments on the ISEE-1 and -2 spacecraft which are in nearly identical orbits passing through the Earth's magneotsphere at radial distances out to about 22.5 Rsub(e). Essentially every crossing of the Earth's bow shock can be associated with an intense burst of electrostatic and whistler-mode turbulence at the shock, with substanial wave intensities in both the upstream and downstream regions. In the magnetosphere high resolution spectrograms of the electric field show an extremely complex distribution of plasma and radio emission, with numerous resonance and cutoff effects. High resolution spectrograms of kilometric radio emissions are also presented which show an extremely complex frequency-time structure with many closely spaced narrow-band emissions. (Auth.)

  10. The results of nuclear tomography in the investigation of tumours of the facial skeleton

    International Nuclear Information System (INIS)

    Uhlenbrock, D.; Radtke, J.; Beyer, H.K.; Machtens, E.; Pastoors, H.; Knappschaftskrankenhaus Langendreer, Essen

    1986-01-01

    We examined 21 patients with tumours of the mouth, one with tumour involvement of the facial skeleton and three with lymph node involvement in the upper neck, by nuclear tomography. Twenty patients with carcinomas of the mouth were also examined by CT. Nuclear tomography was superior to CT in showing the extent of the tumour; in ten patients the extent of the tumour could not be accurately determined, since there was no clear demarcation from normal tissue. Amongst our patients, nuclear tomography was also superior for showing lymph node metastases. Computed tomography is better at showing bone infiltration. Our results indicate that nuclear tomography is better than CT for showing the tumour and lymph nodes. If there is a suspicion of bone involvement, CT should be used in addition. (orig.) [de

  11. Optimized Control Strategy for a Medium-Voltage DVR-Theoretical Investigations and Experimental Results

    DEFF Research Database (Denmark)

    Meyer, Christoph; De Doncker, Rik W.; Li, Yun Wei

    2008-01-01

    the needed voltage amplitude. To avoid this drawback, an optimized control strategy is presented in this paper, which is able to reduce the needed injection voltage of the DVR and concurrently to mitigate the transient distortions at the load side. In the following paper, a brief introduction of the basic...... a small fraction of the energy stored in the DC-link capacitor is used, which makes it impractical for DVRs to compensate relatively long voltage sags. Present control strategies are only able to minimize the distortions at the load or to allow a better utilization of the storage system by minimizing...... DVR principle will be given. Next, three standard control strategies will be compared and an optimized control strategy is developed in this paper. Finally, experimental results using a medium-voltage 10-kV DVR setup will be shown to verify and prove the functionality of the presented control strategy...

  12. Methods of Science Investigation Part 2: Results of Implementation of a Curriculum Fostering Original Scientific Research

    Science.gov (United States)

    Danch, J. M.

    2008-12-01

    Originally designed to allow secondary students with special needs to participate in original scientific research, the Methods of Science Curriculum was piloted in 2008. Students participating included those with special needs, English language learners, and the general population. Students were incrementally graduated from traditional inquiry activities towards authentic student-generated research projects. Students were evaluated via class work grades, an in-school symposium and a pre/post test. 100 percent of participants successfully completed and presented their original research. The pre/post evaluation demonstrated improvement for 91 percent of participants. An unanticipated result was the performance and growth of English language learners, possibly because of the emphasis on the creative and active process of science rather than vocabulary. A teacher-training program is being developed for expansion of the curriculum to additional schools in 2009.

  13. The results of investigation in connection with the 18th Chinese nuclear test

    International Nuclear Information System (INIS)

    1977-01-01

    Concerning the 18th nuclear explosion test of the People's Republic of China, the results of measurements of radioactivity, etc. in Japan are presented. (1) As for gross beta-radioactivity in upper air, the same level as normal was measured in middle and northern Japan. (2) At monitoring posts, the same level as normal was measured across the country. (3) As for gross beta-radioactivity in rain and dry fallout, 56 pCi/ml was detected in Hachijo Island. (4) As for gross beta-radioactivity in airborne dust, 6.0 pCi/m 3 was detected in Fukuoka. (5) As for gross beta-radioactivity in dry fallout the same level as normal was measured. (6) As for the Iodine-131 concentration in fresh milk, 113 pCi/l was detected in Ishikawa Prefecture. (7) Analysis of radionuclides. (8) Data concerning the radioactivity surveillance. (J.P.N.)

  14. Results of isotopic investigations of nitrogen nutrition of apples and cherries

    International Nuclear Information System (INIS)

    Makariev, Z.

    1990-01-01

    Results are reported of 15 N study of absorption and dislocation of nitrogen fertilization in apple and cherry plantations and field trials localized nitrogen fertilization of apple plantations. It is found that there is a good functional relation between the individual roots and all skeletal branches of the crown. The apple- and cherry trees can satisfy their nitrogen needs by a part of their root system and hence the introduction of nitrogen into the whole nutrition area is not absolutely necessary. The localized nitrogen fertilization in every other row or only in the row band of apple plantations increases its biological, economic and ecological efficiency. The method is patented. 2 tabs, 7 figs, 5 refs

  15. New experimental results on the pion-nucleon interaction investigation in the resonance region

    Science.gov (United States)

    Sumachev, V. V.; Beloglazov, Yu. A.; Kovalev, A. I.; Kozlenko, N. G.; Kruglov, S. P.; Kulbardis, A. A.; Novinsky, D. V.; Trautman, V. Yu.; Alekseev, I. G.; Budkovsky, P. E.; Kanavets, V. P.; Koroleva, L. I.; Morozov, B. V.; Nesterov, V. M.; Ryltsov, V. V.; Sulimov, A. D.; Svirida, D. N.; Bazhanov, N. A.; Bunyatova, E. I.

    2002-03-01

    The spin rotation parameters A and R were measured for the elastic pion-proton scattering by the PNPI-ITEP collaboration in the D13 (1700), ΔS31(1900), ΔP33(1920) and ΔD33 (1940) resonances region. These resonances were absent in the set of partial wave analysis (PWA) of the Virginia Polytechnic Institute group (VPI), but was included in the tables of the Review of Particle Physics. The main goal of the experimental program was to resolve the current PWA’s disagreement in spin rotation parameters value predictions. Simultaneously with A and R the polarization parameter P was measured with the purpose to improve the experimental data base and estimate the experimental systematic errors. Our results for spin rotation parameters A and | R| are in agreement with PWA VPI predictions.

  16. The investigation on compressed air quality analysis results of nuclear power plants

    International Nuclear Information System (INIS)

    Sung, K. B.; Kim, H. K.; Kim, W. S.

    2000-01-01

    The compressed air system of nuclear power plants provides pneumatic power for both operation and control of various plant equipment, tools, and instrumentation. Included in the air supply systems are the compressors, coolers, moisture separators, dryers, filters and air receiver tanks that make up the major items of equipment. The service air system provides oil-free compressed air for general plant and maintenance use and the instrument air system provides dry, oil-free, compressed air for both nonessential and essential components and instruments. NRC recommended the periodic checks on GL88-14 'Instrument air supply system problems affecting safety-related equipment'. To ensure that the quality of the instrument air is equivalent to or exceeds the requirement s of ISA-S7.3(1975), air samples are taken at every refueling outage and analyzed for moisture, oil and particulate content. The over all results are satisfied the requirements of ISA-S7.3

  17. [Combustion zone investigation and modelling in fuel flexible suspension fired boilers]. Result summary and status

    Energy Technology Data Exchange (ETDEWEB)

    Lovmand Hvid, S.

    2011-12-15

    The project has been designed to obtain data from a power plant boiler with co-combustion, partly to gain greater knowledge of particle turnover in the fuel zone, partly to support the development of modeling tools. Data collection occurred at Studstrup Power Station Unit 4, where the fuel is a combination of coal and biomass. The boiler is equipped with 24 dust burners, four of which have been converted to firing with biomass. Measurements have been carried out in the flame zone with different fuels: coal alone, coal + straw and coal + wood. During the experiments velocity fields, temperature fields and gas concentration fields were measured in the firing zone. Also, particle samples from the flame zone ware collected. Several measurements are performed with well-known techniques, but in addition, the project developed new optical measurement methods based on UV spectroscopy. They allow measuring other gases than the hitherto known methods and allow you to gain insight into the dynamic variations beyond just mean fields. The collection of particle samples from the boiler was, as expected, a very challenging task under the given conditions, but was carried out with a largely satisfactory result. Analysis of the samples has initially failed to lead to an increased recognition of the speed of the conversion process, but the samples will be analyzed in more detail in other projects. (LN)

  18. Investigation of public exposure resulted from the radioiodine delay tank facility of nuclear medicine department

    Energy Technology Data Exchange (ETDEWEB)

    Yusof, Mohd Fahmi Mohd, E-mail: mfahmi@usm.my; Ali, Abdul Muhaimin Mat; Abdullah, Reduan; Idris, Abdullah Waidi [School of Health Sciences, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan (Malaysia)

    2016-01-22

    The study is carried out to assess the exposure rate that could contribute to public exposure in a radioiodine ward delay tank facility of Radiotherapy, Oncology and Nuclear Medicine, Department, Hospital Universiti Sains Malaysia (HUSM). The exposure rate at several locations including the delay tank room, doorway and at the public walking route was measured using Victoreen 415P-RYR survey meter. The radioactive level of the {sup 131}I waste was measured using Captus 3000 well counting system. The results showed that exposure rate and total count of the delay tank sample increased when the radioiodine ward was fully occupied with patient and reduced when the ward was vacant. Occupancy of radioiodine ward for two consecutive weeks had dramatically increased the exposure rate around the delay tank and radioactive level of {sup 131}I waste. The highest exposure rate and radioactive level was recorded when the ward was occupied for two consecutive weeks with 177.00 µR/h and 58.36 kcpm respectively. The exposure rate decreased 15.76 % when the door of the delay tank room was closed. The exposure rate at public walking route decreased between 15.58 % and 36.92 % as the distance increased between 1 and 3 m.

  19. Investigating dynamic parameters in HWZPR ased on the experimental and calculated results

    Energy Technology Data Exchange (ETDEWEB)

    Nasrazadani, Zahra; Behfamia, Manochehar; Khosandi, Jamshid; Mirvakili, Mohammad [Reactors Research School, Nuclear Science And Technology Research Institute, Atomic Energy Organization of Iran, Esfahan (Iran, Islamic Republic of)

    2016-10-15

    The neutron decay constant, α, and effective delayed neutron fraction, β{sub eff}, are important parameters for the control of the dynamic behavior of nuclear reactors. For the heavy water zero power reactor (HWZPR), this document describes the measurements of the neutron decay constant by noise analysis methods, including variance to mean (VTM) ratio and endogenous pulse source (EPS) methods. The measured α is successively used to determine the experimental value of the effective delayed neutron fraction as well. According to the experimental results, β{sub eff} of the HWZPR reactor under study is equal to 7.84e-3. This value is finally used to validate the calculation of the effective delayed neutron fraction by the Monte Carlo methods that are discussed in the document. Using the Monte Carlo N-Particle (MCNP)-4C code, a β{sub eff} value of 7.58e-3 was obtained for the reactor under study. Thus, the relative difference between the β{sub eff} values determined experimentally and by Monte Carlo methods was estimated to be < 4%.

  20. Preliminary Results of Tectonic Geomorphology Investigation of the Northern Cyprus coasts

    Science.gov (United States)

    Yildirim, Cengiz; Tüysüz, Okan; Melnick, Daniel; Damla Altınbaş, Cevza; Zeynel Öztürk, Muhammed; Oruç Baykara, Mehmet; Shen, Chuan-Chou

    2016-04-01

    Cyprus, an island located in the Eastern Mediterranean region, is a part of subduction zone that defines the plate boundary at the southern margin of the Central Anatolian Plateau. The presence of uplifted marine terraces, wave-cut notches, surface ruptures and tsunami deposits are pieces of evidence of subduction related active deformation in the northern part of the island. To understand timing, mode and rate of deformation, we conducted high-resolution geomorphic mapping of marine terraces and levelling of wave-cut notches by using drone and DGPS. Tsunami boulders and boulder trains reaching up to 5-6 meters were discovered and surface rupture of an earthquake strechting from offshore to onshore was mapped for the first time with this study. Coral fossils were collected from marine terraces and tsunami boulders for age determinations by U-Th and 14C dating techniques, respectively. U-Th dating results indicate 144±12 (2s) ka for the MIS5e terrace at 40 m above sea level and 14C ages show the late Holocene (<4.5 ka) coseismic deformation. Here we will present tectonic implicatios from temporal and spatial distribution of marine terraces and wave-cut notches along the northern Cyprus. This study is supported by the Istanbul Technical University Research Found (Project no: 37548).

  1. Investigation of previously implicated genetic variants in chronic tic disorders

    DEFF Research Database (Denmark)

    Abdulkadir, Mohamed; Londono, Douglas; Gordon, Derek

    2017-01-01

    with those from a large independent case-control cohort. After quality control 71 SNPs were available in 371 trios; 112 SNPs in 179 trios; and 3 SNPs in 192 trios. 17 were candidate SNPs implicated in TS and 2 were implicated in obsessive-compulsive disorder (OCD) or autism spectrum disorder (ASD); 142 were...

  2. The Results of the Bone Mineral Density Screening of Istanbul-Sultanbeyli - Original Investigation

    Directory of Open Access Journals (Sweden)

    İlknur Aktaş

    2006-09-01

    Full Text Available Aim: Our aim of this study is to determine demographic characteristics and social insurance profile of the patients by doing osteoporosis screening in the socioeconomic developing territory. Material and Method: Six thousand eight hundred sixteen cases enrolled in this study, who were living in Istanbul-Sultanbeyli. Bone mineral density was measured by using radiographic absorbsiometry (Metriscan-ALARA. Demographic characteristics and social insurance profile are interrogated. Results: Of the total cases, 19.6% were unemployed, 69.6% were housewive, 4.2% were self-employed, 2.7% were retired, 2.2% were officials, 1.1% were workers, 0.5% were managers. There were not social guaranty on 44.4% of the cases. Of the other cases, 6.9% were members of Emekli Sandığı, 42.3% were members of SSK, 5.4% were members of Bağ-Kur, 1.1% were members of Yeşil Kart. According to the age of the people occurrence of osteoporosis; in 40-49 age group 3.2%, in 50-59 age group 9.5%, in 60-69 age group 32%, in 70 years old and over it was calculated as %48. The overall occurrence of the osteoporosis were 7.8% and 31% of them had not social guaranty. Conclusion: When the cost of the osteoporosis treatment is considered, it seems difficult to have treatment for the cases haven't social insurance. The majority of the same kinds of socioeconomicly developing territories increases the importance of the studies about how to prevent osteoporosis twice as much. (Osteoporoz Dünyasından 2006;12:47-9

  3. Results of the first Seismometer to Investigate Ice and Ocean Structure (SIIOS) Analogue Mission

    Science.gov (United States)

    Della-Giustina, Daniella; Bray, Veronica; "Hop" Bailey, Samuel; Pettit, Erin; Schmerr, Nicholas; Dahl, Peter; Avenson, Brad; Byrne, Shane; SIIOS Team

    2017-10-01

    The icy moons of Europa and Enceladus are thought to have global subsurface oceans in contact with mineral-rich interiors, likely providing the ingredients needed for life as we know it. The possibility of life forming in the ocean or in melt pockets, relies on the presence of a source of energy and chemistry for biological molecule formation. A thick, stagnant ice crust would likely prevent transfer of oxidants from the surface to the water, halting the development of life. The ice thickness and structure is therefore one of the most important and controversial topics in astrobiology.The best way to access an icy moon’s interior structure is with a lander-based seismometer. Our team has identified a commercial-off-the-shelf device as a flight-candidate for operation in the extreme environment of the icy moons. Based on estimates of Europan seismicity, the flight candidate device is sensitive enough to detect the ice-water boundary and pockets of liquid within the ice. Its low mass and low power enables deployment of multiple seismometers in a short-baseline array on a lander. The performance, mass, and volume of this device meet or exceed flight requirements identified in lander studies making a field test of these seismometers highly representative of a flight unit developed for an Ocean Worlds mission.We report the results of the first field campaign for the SIIOS Analogue Mission Program (AMP), which has evaluates the performance of the flight candidate seismometer in Ocean World terrestrial analogue environments. In particular, the first SIIOS AMP field exercise is performed at Gulkana Glacier, Alaska. During the summer melt season Gulkana provides kilometer-scale regions of coexisting ice, water, and silicate material, thereby providing areas with the desired analogue seismic contrasts. During this first mission, we have demonstrated device sensitivity to the detection of seismicity from high frequency (> 50 Hz) active and passive sources, the depth of ice

  4. Results of stainless steel canister corrosion studies and environmental sample investigations

    Energy Technology Data Exchange (ETDEWEB)

    Bryan, Charles R. [Sandia National Laboratories, Albuquerque, NM (United States); Enos, David [Sandia National Laboratories, Albuquerque, NM (United States)

    2014-12-01

    This progress report describes work being done at Sandia National Laboratories (SNL) to assess the localized corrosion performance of container/cask materials used in the interim storage of used nuclear fuel. The work involves both characterization of the potential physical and chemical environment on the surface of the storage canisters and how it might evolve through time, and testing to evaluate performance of the canister materials under anticipated storage conditions. To evaluate the potential environment on the surface of the canisters, SNL is working with the Electric Power Research Institute (EPRI) to collect and analyze dust samples from the surface of in-service SNF storage canisters. In FY 13, SNL analyzed samples from the Calvert Cliffs Independent Spent Fuel Storage Installation (ISFSI); here, results are presented for samples collected from two additional near-marine ISFSI sites, Hope Creek NJ, and Diablo Canyon CA. The Hope Creek site is located on the shores of the Delaware River within the tidal zone; the water is brackish and wave action is normally minor. The Diablo Canyon site is located on a rocky Pacific Ocean shoreline with breaking waves. Two types of samples were collected: SaltSmart™ samples, which leach the soluble salts from a known surface area of the canister, and dry pad samples, which collected a surface salt and dust using a swipe method with a mildly abrasive ScotchBrite™ pad. The dry samples were used to characterize the mineralogy and texture of the soluble and insoluble components in the dust via microanalytical techniques, including mapping X-ray Fluorescence spectroscopy and Scanning Electron Microscopy. For both Hope Creek and Diablo Canyon canisters, dust loadings were much higher on the flat upper surfaces of the canisters than on the vertical sides. Maximum dust sizes collected at both sites were slightly larger than 20 μm, but Phragmites grass seeds ~1 mm in size, were observed on the tops of the Hope Creek canisters

  5. Investigation of sol-gel transition by rheological methods. Part II. Results and discussion.

    Directory of Open Access Journals (Sweden)

    KUDRYAVTSEV Pavel Gennadievich

    2017-10-01

    Full Text Available In this work rheological studies of the gelling process were carried out. We have developed a measuring system for studying the rheology of the gelation process. It consisted of several measuring cells of the Weiler-Rebinder type, system for automatic regulation of the composition of the medium and thermostabilization system. This complex is designed to measure the dependence of the value of the ultimate shear stress as a function of time, from the start of the sol-gel transition to the complete conversion of the sol to the gel. The developed device has a wide range of measured values of critical shear stresses τ0 = (0,05÷50000 Dyne/cm2. Using the developed instrument, it was possible to establish the shape of the initial section of the curve τ0 = f(t and develop a methodology for more accurate determination of gelation time. The developed method proved that the classical method for determining the start time of the sol-gel transition using the point of intersection of the tangent to the linear part of the rheological curve τ0 = f(t, gives significantly distorted results. A new phenomenon has been discovered: the kinetic curves in the coordinates of the Avrami-Erofeev-Bogolyubov equation have an inflection point which separates the kinetic curve into two parts, the initial and the final. It was found that the constant k in the Avrami–Erofeev–Bogolyubov equation does not depend on the temperature and is the same for both the initial and final parts of the kinetic curve. It depends only on the chemical nature of the reacting system. It was found that for the initial section of the kinetic curves, the value of the parameter n in the Avrami-Erofeev-Bogolyubov equation was n = 23,4±2,8 and, unlike the final section of the rheological curve, does not depend on temperature. A large value of this parameter can be interpreted as the average number of directions of growth of a fractal aggregate during its growth. The value of this parameter

  6. Day-and-Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home

    NARCIS (Netherlands)

    Renard, Eric; Farret, Anne; Kropff, Jort; Bruttomesso, Daniela; Messori, Mirko; Place, Jerome; Visentin, Roberto; Calore, Roberta; Toffanin, Chiara; Di Palma, Federico; Lanzola, Giordano; Magni, Paolo; Boscari, Federico; Galasso, Silvia; Avogaro, Angelo; Keith-Hynes, Patrick; Kovatchev, Boris; del Favero, Simone; Cobelli, Claudio; Magni, Lalo; DeVries, J. Hans

    2016-01-01

    After testing of a wearable artificial pancreas (AP) during evening and night (E/N-AP) under free-living conditions in patients with type 1 diabetes (T1D), we investigated AP during day and night (D/N-AP) for 1 month. Twenty adult patients with T1D who completed a previous randomized crossover study

  7. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh

    2011-01-01

    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  8. Secondary recurrent miscarriage is associated with previous male birth.

    LENUS (Irish Health Repository)

    Ooi, Poh Veh

    2012-01-31

    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53\\/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32\\/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78\\/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16\\/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19\\/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13\\/32 vs. 6\\/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.

  9. Uterine rupture without previous caesarean delivery

    DEFF Research Database (Denmark)

    Thisted, Dorthe L. A.; H. Mortensen, Laust; Krebs, Lone

    2015-01-01

    OBJECTIVE: To determine incidence and patient characteristics of women with uterine rupture during singleton births at term without a previous caesarean delivery. STUDY DESIGN: Population based cohort study. Women with term singleton birth, no record of previous caesarean delivery and planned...... vaginal delivery (n=611,803) were identified in the Danish Medical Birth Registry (1997-2008). Medical records from women recorded with uterine rupture during labour were reviewed to ascertain events of complete uterine rupture. Relative Risk (RR) and adjusted Relative Risk Ratio (aRR) of complete uterine...... rupture with 95% confidence intervals (95% CI) were ascertained according to characteristics of the women and of the delivery. RESULTS: We identified 20 cases with complete uterine rupture. The incidence of complete uterine rupture among women without previous caesarean delivery was about 3...

  10. Dumping of radioactive waste and investigation of contamination in the Kara Sea. Results from 3 years of investigations (1992-1994) in the Kara Sea

    International Nuclear Information System (INIS)

    Strand, P.; Foeyn, L.; Nikitin, A.I.

    1996-03-01

    The report summarises the results obtained from the joint Russian-Norwegian investigation concerning the consequences of dumping of radioactive waste in the Kara Sea. Three expeditions were undertaken to the Kara Sea and the present dumping sites for radioactive waste. Samples of water, sediments and biota were collected and analysed. An impact and risk assessment was performed, based on the information provided through the joint cooperation. Enhanced levels and artificially produced radionuclides in the sediments collected in the very close vicinity of almost all localised dumped objects, demonstrate that leakage occur. No contribution from dumped radioactive waste was observed in the open Kara Sea. Due to the potential for leakage from the dumped waste in the future and the presence of other potential sources in the area, a regular monitoring programme is highly recommended. 65 refs., 42 figs., 16 tabs

  11. Dumping of radioactive waste and investigation of contamination in the Kara Sea. Results from 3 years of investigations (1992-1994) in the Kara Sea

    Energy Technology Data Exchange (ETDEWEB)

    Strand, P. [Statens Straalevern, Oesteraas (Norway); Foeyn, L. [Norsk Inst. for Vannforskning, Oslo (Norway); Nikitin, A.I. [SPA ``Typhoon``, Roshydromet (Russian Federation)] [and others

    1996-03-01

    The report summarises the results obtained from the joint Russian-Norwegian investigation concerning the consequences of dumping of radioactive waste in the Kara Sea. Three expeditions were undertaken to the Kara Sea and the present dumping sites for radioactive waste. Samples of water, sediments and biota were collected and analysed. An impact and risk assessment was performed, based on the information provided through the joint cooperation. Enhanced levels and artificially produced radionuclides in the sediments collected in the very close vicinity of almost all localised dumped objects, demonstrate that leakage occur. No contribution from dumped radioactive waste was observed in the open Kara Sea. Due to the potential for leakage from the dumped waste in the future and the presence of other potential sources in the area, a regular monitoring programme is highly recommended. 65 refs., 42 figs., 16 tabs.

  12. Previously unknown organomagnesium compounds in astrochemical context

    OpenAIRE

    Ruf, Alexander

    2018-01-01

    We describe the detection of dihydroxymagnesium carboxylates (CHOMg) in astrochemical context. CHOMg was detected in meteorites via ultrahigh-resolving chemical analytics and represents a novel, previously unreported chemical class. Thus, chemical stability was probed via quantum chemical computations, in combination with experimental fragmentation techniques. Results propose the putative formation of green-chemical OH-Grignard-type molecules and triggered fundamental questions within chemica...

  13. Investigating the importance of Delaunay-based definition of atomic interactions in scoring of protein-protein docking results.

    Science.gov (United States)

    Jafari, Rahim; Sadeghi, Mehdi; Mirzaie, Mehdi

    2016-05-01

    The approaches taken to represent and describe structural features of the macromolecules are of major importance when developing computational methods for studying and predicting their structures and interactions. This study attempts to explore the significance of Delaunay tessellation for the definition of atomic interactions by evaluating its impact on the performance of scoring protein-protein docking prediction. Two sets of knowledge-based scoring potentials are extracted from a training dataset of native protein-protein complexes. The potential of the first set is derived using atomic interactions extracted from Delaunay tessellated structures. The potential of the second set is calculated conventionally, that is, using atom pairs whose interactions were determined by their separation distances. The scoring potentials were tested against two different docking decoy sets and their performances were compared. The results show that, if properly optimized, the Delaunay-based scoring potentials can achieve higher success rate than the usual scoring potentials. These results and the results of a previous study on the use of Delaunay-based potentials in protein fold recognition, all point to the fact that Delaunay tessellation of protein structure can provide a more realistic definition of atomic interaction, and therefore, if appropriately utilized, may be able to improve the accuracy of pair potentials. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Oskarshamn site investigation. Searching for evidence of late- or post-glacial faulting in the Oskarshamn region. Results from 2004

    International Nuclear Information System (INIS)

    Lagerbaeck, Robert; Sundh, Martin; Svantesson, Sven-Ingemund; Svedlund, Jan-Olov

    2005-11-01

    In connection with previous aerial photo interpretation, a number of prominent escarpments, hypothetically indicative of late- or postglacial faulting, were noted in the mainland part of the investigation area. Most of these scarps were field-checked in 2004 and found to be more or less intensely glacially abraded, i.e. formed prior to the last deglaciation. On the island of Oeland a very distinct, straight lineament was likewise noticed in connection with aerial photo interpretation. In the field the lineament was identified as a step in the ground surface or as a very distinct vegetational boundary, the latter due to a difference in thickness of the soil cover on either side of the lineament. The step in the ground surface clearly derives from a bedrock scarp but it was not possible to determine its nature or age in the absence of stratigraphical information. No systematic search for unstable boulders, tentatively refuting the occurrence of major earthquakes in the vicinity, was carried out, but a few specimens were encountered during minor excursions in different parts of the investigation area. However, without estimating how much earthquake-induced ground motion these boulders could withstand before they would topple over, it is difficult to judge their significance as palaeo-earthquake indicators. Stratigraphical investigations in machine-dug trenches were carried out at three localities along the Faarbo esker, all situated west of the candidate area at Simpevarp. A total of some 170 m of trenches were excavated and investigated. Deposits of loosely packed sand and coarse silt were encountered in almost all the trenches and in some of them a clayey bed covered the sandy-silty deposits. When shaken by strong earthquakes in a water saturated state, such deposits are highly likely to liquefy but no significant features related to liquefaction were noted in any of the trenches. However, as the excavation sites are situated some 30-100 m above the present sea

  15. Investigation of newborns with abnormal results in a newborn screening program for four lysosomal storage diseases in Brazil

    Directory of Open Access Journals (Sweden)

    Heydy Bravo

    2017-09-01

    Full Text Available Lysosomal storage diseases (LSDs are genetic disorders, clinically heterogeneous, mainly caused by defects in genes encoding lysosomal enzymes that degrade macromolecules. Several LSDs already have specific therapies that may improve clinical outcomes, especially if introduced early in life. With this aim, screening methods have been established and newborn screening (NBS for some LSDs has been developed. Such programs should include additional procedures for the confirmation (or not of the cases that had an abnormal result in the initial screening. We present here the methods and results of the additional investigation performed in four babies with positive initial screening results in a program of NBS for LSDs performed by a private laboratory in over 10,000 newborns in Brazil. The suspicion in these cases was of Mucopolysaccharidosis I - MPS I (in two babies, Pompe disease and Gaucher disease (one baby each. One case of pseudodeficiency for MPS I, 1 carrier for MPS I, 1 case of pseudodeficiency for Pompe disease and 1 carrier for Gaucher disease were identified. This report illustrates the challenges that may be encountered by NBS programs for LSDs, and the need of a comprehensive protocol for the rapid and precise investigation of the babies who have an abnormal screening result.

  16. Recent results from experimental and numerical investigations of the self-magnetically BΘ-insulated ion diode

    International Nuclear Information System (INIS)

    Bauer, W.; Hoppe, P.; Bachmann, H.

    1996-01-01

    Comparison of the observed and calculated data of foil acceleration experiments on KALIF showed discrepancies which called for a re-investigation of the beam characteristics produced by the Bo-Diode. It was shown that the peak power density achieved in the focus is only 0.15 TW/cm 2 and not 0.25 TW/cm 2 as reported earlier. In addition, a most likely time history of the proton power density with a FWHM pulse duration of 60 ns in the focus was derived. The experiments led to a new description of the operating principle of this diode, which was confirmed by particle-in-cell-simulations. As a result of these considerations, suggestions for a new design of the diode were developed and investigated by simulations. (author). 7 figs., 6 refs

  17. Results of verification and investigation of wind velocity field forecast. Verification of wind velocity field forecast model

    International Nuclear Information System (INIS)

    Ogawa, Takeshi; Kayano, Mitsunaga; Kikuchi, Hideo; Abe, Takeo; Saga, Kyoji

    1995-01-01

    In Environmental Radioactivity Research Institute, the verification and investigation of the wind velocity field forecast model 'EXPRESS-1' have been carried out since 1991. In fiscal year 1994, as the general analysis, the validity of weather observation data, the local features of wind field, and the validity of the positions of monitoring stations were investigated. The EXPRESS which adopted 500 m mesh so far was improved to 250 m mesh, and the heightening of forecast accuracy was examined, and the comparison with another wind velocity field forecast model 'SPEEDI' was carried out. As the results, there are the places where the correlation with other points of measurement is high and low, and it was found that for the forecast of wind velocity field, by excluding the data of the points with low correlation or installing simplified observation stations to take their data in, the forecast accuracy is improved. The outline of the investigation, the general analysis of weather observation data and the improvements of wind velocity field forecast model and forecast accuracy are reported. (K.I.)

  18. The use of scientific and technical results from underground research laboratory investigations for the geological disposal of radioactive waste

    International Nuclear Information System (INIS)

    2001-09-01

    The objective of the report is to provide information on the use of results obtained from underground research laboratory investigations for the development of a deep geological repository system for long lived and/or high level radioactive waste including spent fuel. Specifically, it should provide Member States that intend to start development of a geological disposal system with an overview of existing facilities and of the sorts and quality of results that have already been acquired. The report is structured into six main themes: rock characterization methodologies and testing; assessment of the geological barrier; assessment of the engineered barrier system; respository construction techniques; demonstration of repository operations; confidence building and international co-operation

  19. Investigating output and energy variations and their relationship to delivery QA results using Statistical Process Control for helical tomotherapy.

    Science.gov (United States)

    Binny, Diana; Mezzenga, Emilio; Lancaster, Craig M; Trapp, Jamie V; Kairn, Tanya; Crowe, Scott B

    2017-06-01

    The aims of this study were to investigate machine beam parameters using the TomoTherapy quality assurance (TQA) tool, establish a correlation to patient delivery quality assurance results and to evaluate the relationship between energy variations detected using different TQA modules. TQA daily measurement results from two treatment machines for periods of up to 4years were acquired. Analyses of beam quality, helical and static output variations were made. Variations from planned dose were also analysed using Statistical Process Control (SPC) technique and their relationship to output trends were studied. Energy variations appeared to be one of the contributing factors to delivery output dose seen in the analysis. Ion chamber measurements were reliable indicators of energy and output variations and were linear with patient dose verifications. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  20. Results of experimental investigations on the heat conductivity of nanofluids based on diathermic oil for high temperature applications

    International Nuclear Information System (INIS)

    Colangelo, Gianpiero; Favale, Ernani; Risi, Arturo de; Laforgia, Domenico

    2012-01-01

    Highlights: ► This work reports experimental results for nanofluids using diathermic oil as base fluid. ► Nanofluids with CuO, Al 2 O 3 , ZnO and Cu, with different shapes and concentrations have been tested. ► Thermal conductivity enhancement of nanofluids with diathermic oil is higher than those with demineralized water. ► Better results were obtained with ZnO, for nanofluids with metal oxide nanoparticles. -- Abstract: The work reported in this paper shows the experimental results from a study on diathermic oil based nanofluids. Diathermic oil finds application in renewable energy, cogeneration and cooling systems. For example, it is used in solar thermodynamic or biomass plants, where high efficiency, compact volumes and high energy fluxes are required. Besides diathermic oil is very important in those applications where high temperatures are reached or where the use of water or vapor is not suitable. Therefore an improvement of diathermic oil thermo-physical properties, by using of nanoparticles, can increase the performance of the systems. In literature there are not many experimental data on diathermic oil based nanofluids because many experimental campaigns are focused on water nanofluids. Samples of nanofluids, with nanoparticles of CuO, Al 2 O 3 , ZnO and Cu, having different shapes and concentrations varying from 0.0% up to 3.0%, have been produced and their thermal conductivity has been measured by means of hot-wire technique, according to the standard ASTM D 2717-95. Measurements were carried out to investigate the effects of volume fraction, particle size of nanoparticles on the thermal conductivity of the nanofluid. The effect of temperature has been also investigated in the range 20–60 °C. A dependence was observed on the measured parameters and the results showed that the heat transfer performance of diathermic oil enhances more than water with the same nanoparticles.

  1. Results of the fire training facility siting investigation at Davis-Monthan Air Force Base, Tucson, Arizona

    Energy Technology Data Exchange (ETDEWEB)

    Witt, D.A.; Smuin, D.R.; Williams, J.K.

    1988-05-01

    An investigative drilling and sampling survey at the site of a proposed Fire Training Facility (FTF) at Davis--Monthan Air Force Base, Tuscon, Arizona, was conducted. The objectives of this survey were to provide environmental/chemical information and geotechnical characteristics of the site from soil samples collected at the proposed site, to determine the concentrations of volatile organic compounds (VOCs) and petroleum hydrocarbon contaminants in these samples, and to make an assessment of survey data to determine if the proposed FTF site is environmentally and geotechnically suitable. Results of the chemical analyses indicate the presence of subsurface petroleum hydrocarbons directly related to the former fire training burn pits. Although one of the samples was found to have a relatively high concentration of petroleum hydrocarbons (9300 ..mu..g/g), the contamination was limited in vertical extent, and the location of the bore hole was approximately 61 m (200 ft) downgradient from any construction planned for the proposed FTF site. All chemical analyses performed on bore hole samples for VOCs were found to be at or below detection limits. This indicates that no significant subsurface concentrations of hazardous wastes are present at the site of the planned FTF. The geotechnical investigation performed by The Earth Technology Corporation provided several recommendations for construction of the FTF, but presents no data to indicate that the site planned for the proposed FTF is geotechnically unsuitable. The results of this siting investigation support the location of the new FTF in close proximity to the present fire training area as planned. 10 refs., 6 figs.

  2. Experimental investigation and modelling of surface roughness and resultant cutting force in hard turning of AISI H13 Steel

    Science.gov (United States)

    Boy, M.; Yaşar, N.; Çiftçi, İ.

    2016-11-01

    In recent years, turning of hardened steels has replaced grinding for finishing operations. This process is compared to grinding operations; hard turning has higher material removal rates, the possibility of greater process flexibility, lower equipment costs, and shorter setup time. CBN or ceramic cutting tools are widely used hard part machining. For successful application of hard turning, selection of suitable cutting parameters for a given cutting tool is an important step. For this purpose, an experimental investigation was conducted to determine the effects of cutting tool edge geometry, feed rate and cutting speed on surface roughness and resultant cutting force in hard turning of AISI H13 steel with ceramic cutting tools. Machining experiments were conducted in a CNC lathe based on Taguchi experimental design (L16) in different levels of cutting parameters. In the experiments, a Kistler 9257 B, three cutting force components (Fc, Ff and Fr) piezoelectric dynamometer was used to measure cutting forces. Surface roughness measurements were performed by using a Mahrsurf PS1 device. For statistical analysis, analysis of variance has been performed and mathematical model have been developed for surface roughness and resultant cutting forces. The analysis of variance results showed that the cutting edge geometry, cutting speed and feed rate were the most significant factors on resultant cutting force while the cutting edge geometry and feed rate were the most significant factor for the surface roughness. The regression analysis was applied to predict the outcomes of the experiment. The predicted values and measured values were very close to each other. Afterwards a confirmation tests were performed to make a comparison between the predicted results and the measured results. According to the confirmation test results, measured values are within the 95% confidence interval.

  3. Event sequence variability in healthy swallowing: building on previous findings.

    Science.gov (United States)

    Molfenter, Sonja M; Leigh, Chelsea; Steele, Catriona M

    2014-04-01

    This study builds on previous work by Kendall, Leonard, and McKenzie, which investigated event sequence variability for 12 paired events during swallowing by healthy volunteers. They identified four event pairs that always occurred in a stereotyped order and a most common occurring overall order of events during swallowing. In the current study, we investigated overall event sequencing and the same four paired events in a sample of swallows by healthy young (under 45 years old) volunteers. Data were collected during a 16-swallow lateral videofluoroscopy protocol, which included manipulations of bolus volume, barium density, bolus viscosity, and swallow cueing. Our results agreed with previous findings that variable event sequencing is found in healthy swallowing, and, in regard to obligatory sequencing of two paired events, movement of the arytenoids toward the base of the epiglottis begins prior to upper esophageal sphincter (UES) opening and maximum hyolaryngeal approximation occurs after UES opening. However, our data failed to replicate the previous findings that there is obligatory sequencing of maximum pharyngeal constriction after maximal UES distension and the UES opens before bolus arrival at the UES. The most common observed overall event sequence reported by Kendall et al. was observed in only 4/293 swallows in our dataset. Manipulations of bolus volume, bolus viscosity, barium concentration, swallow cueing, and swallow repetitions could not completely account for the differences observed between the two studies.

  4. Results of investigations regarding the physical and mechanical properties of the martensitic 9% Cr steel EUROFER '97

    International Nuclear Information System (INIS)

    Schirra, M.; Falkenstein, A.; Graf, P.; Heger, S.; Kempe, H.; Lindau, R.; Zimmermann, H.

    2002-04-01

    Following the history of the development activities from conventional martensitic 12% Cr steel, MANET and OPTIFER up to low-activated EUROFER (RAFM steel), the results obtained from experiments on rods of 100 mm diameter and plates of 14 mm shall be presented for a basic characterization. The physical and mechanical properties shall be compared with those of OPTIFER-1W and the F82H-mod 2% W steel. To determine the conversion behavior, a continuous cct diagram was plotted. Hardening experiments in the temperature range of 850 - 1120 C illustrated the range of maximum hardness as well as grain size development. The notch impact behavior was described for various heat treatments and sample types at test temperatures ranging from +60 to -100 C. Tensile strengths were determined for various heat treatments at temperatures ranging from room temperature to 700 C. Aging due to a long-term heat treatment was investigated by means of stabilization annealing experiments. Creep rupture strength and creeping were investigated in the temperature range of 450 - 650 C. So far, a duration of up to about 15 000 h has been covered by the experiments. (orig.)

  5. Books average previous decade of economic misery.

    Science.gov (United States)

    Bentley, R Alexander; Acerbi, Alberto; Ormerod, Paul; Lampos, Vasileios

    2014-01-01

    For the 20(th) century since the Depression, we find a strong correlation between a 'literary misery index' derived from English language books and a moving average of the previous decade of the annual U.S. economic misery index, which is the sum of inflation and unemployment rates. We find a peak in the goodness of fit at 11 years for the moving average. The fit between the two misery indices holds when using different techniques to measure the literary misery index, and this fit is significantly better than other possible correlations with different emotion indices. To check the robustness of the results, we also analysed books written in German language and obtained very similar correlations with the German economic misery index. The results suggest that millions of books published every year average the authors' shared economic experiences over the past decade.

  6. Stock market returns and clinical trial results of investigational compounds: an event study analysis of large biopharmaceutical companies.

    Science.gov (United States)

    Hwang, Thomas J

    2013-01-01

    For biopharmaceutical companies, investments in research and development are risky, and the results from clinical trials are key inflection points in the process. Few studies have explored how and to what extent the public equity market values clinical trial results. Our study dataset matched announcements of clinical trial results for investigational compounds from January 2011 to May 2013 with daily stock market returns of large United States-listed pharmaceutical and biotechnology companies. Event study methodology was used to examine the relationship between clinical research events and changes in stock returns. We identified public announcements for clinical trials of 24 investigational compounds, including 16 (67%) positive and 8 (33%) negative events. The majority of announcements were for Phase 3 clinical trials (N = 13, 54%), and for oncologic (N = 7, 29%) and neurologic (N = 6, 24%) indications. The median cumulative abnormal returns on the day of the announcement were 0.8% (95% confidence interval [CI]: -2.3, 13.4%; P = 0.02) for positive events and -2.0% (95% CI: -9.1, 0.7%; P = 0.04) for negative events, with statistically significant differences from zero. In the day immediately following the announcement, firms with positive events were associated with stock price corrections, with median cumulative abnormal returns falling to 0.4% (95% CI: -3.8, 12.3%; P = 0.33). For firms with negative announcements, the median cumulative abnormal returns were -1.7% (95% CI: -9.5, 1.0%; P = 0.03), and remained significantly negative over the two day event window. The magnitude of abnormal returns did not differ statistically by indication, by trial phase, or between biotechnology and pharmaceutical firms. The release of clinical trial results is an economically significant event and has meaningful effects on market value for large biopharmaceutical companies. Stock return underperformance due to negative events is greater in magnitude and persists longer than

  7. Investigating Heavy Water Zero Power Reactors with a New Core Configuration Based on Experiment and Calculation Results

    Directory of Open Access Journals (Sweden)

    Zahra Nasrazadani

    2017-02-01

    Full Text Available The heavy water zero power reactor (HWZPR, which is a critical assembly with a maximum power of 100 W, can be used in different lattice pitches. The last change of core configuration was from a lattice pitch of 18–20 cm. Based on regulations, prior to the first operation of the reactor, a new core was simulated with MCNP (Monte Carlo N-Particle-4C and WIMS (Winfrith Improved Multigroup Scheme–CITATON codes. To investigate the criticality of this core, the effective multiplication factor (Keff versus heavy water level, and the critical water level were calculated. Then, for safety considerations, the reactivity worth of D2O, the reactivity worth of safety and control rods, and temperature reactivity coefficients for the fuel and the moderator, were calculated. The results show that the relevant criteria in the safety analysis report were satisfied in the new core. Therefore, with the permission of the reactor safety committee, the first criticality operation was conducted, and important physical parameters were measured experimentally. The results were compared with the corresponding values in the original core.

  8. Preliminary investigation results as applied to utilization of Ukrainian salt formations for disposal of high-level radioactive waste

    International Nuclear Information System (INIS)

    Shekhunova, S.B.; Khrushchov, D.P.; Petrichenko, O.I.

    1994-01-01

    The salt-bearing formations have been investigated in five regions of Ukraine. Upper Devonian and Lower Permian evaporite formations in Dnieper-Donets Depression and in the NW part of Donets basin are considered to be promising for disposal of high-level radioactive waste (HLRW). Rock salt occurs there either as bedded salts or as salt pillows and salt diapirs. Preliminary studies have resulted in selection of several candidate sites that show promise for construction of a subsurface pilot lab. Ten salt domes and two sites in bedded salts have been proposed for further exploration. Based on microstructural studies it is possible to separate the body of a salt structure and to locate within its limits the rock salt structure and to locate within its limits the rock salt blocks of different genesis, i.e.: (a) blocks characteristic of initial undisturbed sedimentary structure; (b) flow zones; (c) sliding planes; (d) bodies of loose or uncompacted rock salt. Ultramicrochemical examination of inclusions in halite have shown that they are composed of more than 40 minerals. It is emphasized that to assess suitability of a structure for construction of subsurface lab, and also the potential construction depth intervals, account should be taken of the results of ultra microchemical and microstructural data

  9. THE RESULTS OF THE DEFECT PLACES INVESTIGATION OF DONETSK RAILWAY ROAD BED BY GROUND PENETRATING RADAR COMPLEX

    Directory of Open Access Journals (Sweden)

    V. D. Petrenko

    2014-10-01

    Full Text Available Purpose. Defective places definition of road bed at ground penetrating radar is examined. Methodology. For achievement of this goal the experimental research on ground penetrating radar inspection of road bed defective places of the Donetsk Railway, which are caused by a complex of various reasons of geotechnical and constructive character, were conducted. Findings. According to these diagnostic results of road bed on the three districts of the Donetsk Railway is revealed the main causes which lead to the defects appearance, deformities and injuries in it, there is abuse of process parameters and modify its physic mechanical soil properties of natural and technology-related factors. As it is established, the use of ground penetrating radar of series “Losa” on the railways of Ukraine allows searching ballast tank in the body of road bed, defining damp places in soil road bed and foundations, to find arrangement of foreign matter in the soil road bed and work search heterogeneity and places weakening soil. In addition, the use of ground penetrating radar provides rapid detection of defects, deformation and damage of railway track, especially in areas the most dangerous for rolling stock that creates the high level security at the main and auxiliary lines of Ukrzaliznytsia. In conducting the research was justified the high level of reliability and performance with autonomous use of ground penetrating radar. Originality. In modern conditions of defects determination, deformations and damages by traditional methods with application of engineering-geological investigations, it is impossible in connection with their insufficient efficiency. Therefore the using of highly effective methodology of expeditious tool identification of defective places allows reducing significantly the periods of repair of a railway track which is very important for introduction of the high-speed movement on the Ukrainian Railways. Practical value. On the basis of the

  10. Results and perspectives of the investigation of traditional and thermal stress induced thermophoresis of particles in gas in microgravity

    Science.gov (United States)

    Vedernikov, Andrei; Balapanov, Daniyar; Beresnev, Sergey; Queeckers, Patrick

    Thermophoretic motion of particles suspended in a gas has been a subject of extensive theoretical and experimental investigations for many years because of its wide spread in nature, significance for fundamental and applied aerosol physic. Negative thermophoresis, i.e. solid particle motion towards hotter region in a gas and not as usually from hotter region, was predicted more than 40 years ago and remains an unsolved problem for a choice between different models treating main driving mechanisms -- thermal slip and thermal stress induced gas motion. For a problem of negative thermophoresis, we present experimental evidences in favor of the latter mechanism based on direct observation of particle motion at microgravity; Knudsen particle number 2\\cdot 10(-3) (Kn being the ratio of the molecular mean free path to the particle size); particle-to-gas heat conductivity ratios 2\\cdot 10(4) for copper solid particles and 1.8 for glass bubbles. For both types of particles the experimental results fit well the gas kinetic model of Beresnev and Chernyak [1]. We present characteristics of a set-up and procedures that are able to provide sufficient accuracy and volume of experimental data for testing any model of particle thermophoresis. High quality microgravity is a necessity for such investigations. The short duration microgravity of drop towers suits well this requirement. The sign and value of the thermophoretic force strongly depends on the Knudsen number, particle-to-gas heat conductivity ratio and accommodation coefficients, all of which vary within several decimal orders of magnitude. In order to make crucial conclusions on the choice of the adequate model, there should be hundreds of short duration microgravity experiments. The European Space Agency scientific project Interaction in Cosmic and Atmospheric Particle Systems (ICAPS) [2] planned for the International Space Station, provides complementary opportunities for the investigation of thermophoresis at large

  11. Induced vaginal birth after previous caesarean section

    Directory of Open Access Journals (Sweden)

    Akylbek Tussupkaliyev

    2016-11-01

    Full Text Available Introduction The rate of operative birth by Caesarean section is constantly rising. In Kazakhstan, it reaches 27 per cent. Research data confirm that the percentage of successful vaginal births after previous Caesarean section is 50–70 per cent. How safe the induction of vaginal birth after Caesarean (VBAC remains unclear. Methodology The studied techniques of labour induction were amniotomy of the foetal bladder with the vulsellum ramus, intravaginal administration of E1 prostaglandin (Misoprostol, and intravenous infusion of Oxytocin-Richter. The assessment of rediness of parturient canals was conducted by Bishop’s score; the labour course was assessed by a partogram. The effectiveness of labour induction techniques was assessed by the number of administered doses, the time of onset of regular labour, the course of labour and the postpartum period and the presence of complications, and the course of the early neonatal period, which implied the assessment of the child’s condition, described in the newborn development record. The foetus was assessed by medical ultrasound and antenatal and intranatal cardiotocography (CTG. Obtained results were analysed with SAS statistical processing software. Results The overall percentage of successful births with intravaginal administration of Misoprostol was 93 per cent (83 of cases. This percentage was higher than in the amniotomy group (relative risk (RR 11.7 and was similar to the oxytocin group (RR 0.83. Amniotomy was effective in 54 per cent (39 of cases, when it induced regular labour. Intravenous oxytocin infusion was effective in 94 per cent (89 of cases. This percentage was higher than that with amniotomy (RR 12.5. Conclusions The success of vaginal delivery after previous Caesarean section can be achieved in almost 70 per cent of cases. At that, labour induction does not decrease this indicator and remains within population boundaries.

  12. Investigation of study items for the patterns of care study in the radiotherapy of laryngeal cancer: preliminary results

    International Nuclear Information System (INIS)

    Chung, Woong Ki; Ahn, Sung Ja; Kim, Il Han

    2003-01-01

    In order to develop the national guide-lines for the standardization of radiotherapy we are planning to establish a web-based, on-line data-base system for laryngeal cancer. As a first step this study was performed to accumulate the basic clinical information of laryngeal cancer and to determine the items needed for the data-base system. We analyzed the clinical data of patients who were treated under the diagnosis of laryngeal cancer from January 1998 through December 1999 in the South-west area of Korea. Eligibility criteria of the patients are as follows: 18 years or older, currently diagnosed with primary epithelial carcinoma of larynx, and no history of previous treatments for another cancers and the other laryngeal diseases. The items were developed and filled out by radiation oncologist who are members of Korean Southwest Radiation Oncology Group. SPSS v10.0 software was used for statistical analysis, Data of forty-five patients were collected. Age distribution of patients ranged from 28 to 88 years (median, 61). Laryngeal cancer occurred predominantly in males (10: t sex ratio). Twenty-eight patients (62%) had primary cancers in the glottis and 17 (38%) in the supraglottis. Most of them were diagnosed pathologically as squamous cell carcinoma (44/45, 98%). Twenty-four of 28 glottic cancer patients (86%) had AJCC (American Joint Committee on Cancer) stage l/ll, but 50% (8/16) had in supraglottic cancer patients (p=0.02). Most patients (89%) had the symptom of hoarseness. Indirect laryngoscopy was done in all patients and direct laryngoscopy was performed in 43 (98%) patients. Twenty-one of 28 (75%) glottic cancer cases and 6 of 17 (35%) supraglottic cancer cases were treated with radiation alone, respectively. The combined treatment of surgery and radiation was used in 5 (18%) glottic and 8 (47%) supraglottic patients. Chemotherapy and radiation was used in 2 (7%) glottic and 3 (18%) supraglottic patients. There was no statistically significant difference in

  13. Performance investigation of low – Concentration photovoltaic systems under hot and arid conditions: Experimental and numerical results

    International Nuclear Information System (INIS)

    Yousef, Mohamed S.; Abdel Rahman, Ali K.; Ookawara, S.

    2016-01-01

    Highlights: • Influence of cooling on the performance of photovoltaic systems. • A comprehensive model (optical, thermal, and electrical) was developed. • Experimental measurements were conducted under hot climate conditions. • For conventional photovoltaic with cooling, about 11% more power was obtained. • For concentrated photovoltaic with cooling, about 15% more power was obtained. - Abstract: In this study, a comparative performance analysis was performed between a conventional photovoltaic system and a low-concentration photovoltaic system. Two typical photovoltaic modules and two compound parabolic concentrating photovoltaic systems were examined. A Cooling system was employed to lower the temperature of the solar cells in each of the two configurations. Experimental and numerical investigations of the performance of the two arrangements with and without cooling were presented. Experiments were conducted outdoors at the Egypt-Japan University of Science and Technology, subjected to the hot climate conditions of New Borg El-Arab City, Alexandria, Egypt (Longitude/Latitude: E 029°42′/N 30°55′). A comprehensive system model was established, which comprises an optical model, coupled with thermal and electrical models. The coupled model was developed analytically and solved numerically, using MATLAB software, to assess the overall performance of the two configurations, considering the concentration ratio of the concentrated photovoltaic system to be 2.4X. The results indicated that cooling the solar panels considerably improved the electrical power yield of the photovoltaic systems. By employing cooling, the temperatures of the conventional photovoltaic system and the concentrated photovoltaic system were effectively lowered by approximately 25% and 30%, respectively, resulting in a significant enhancement in the electrical power output of the photovoltaic system by 11% and that of the concentrated photovoltaic system by 15%. Furthermore, the

  14. 22 CFR 40.91 - Certain aliens previously removed.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Certain aliens previously removed. 40.91... IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED Aliens Previously Removed § 40.91 Certain aliens previously removed. (a) 5-year bar. An alien who has been found inadmissible, whether as a result...

  15. Toxicity and survival results of a phase II study investigating the role of postoperative chemoradioimmunotherapy for gastric adenocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Bese, N.S.; Yildirim, A.; Oeber, A. [Dept. of Radiation Oncology, Istanbul Univ., Cerrahpasa Medical School, Istanbul (Turkey); Bueyuekuenal, E.; Oezgueroglu, M.; Demir, G.; Mandel, N.M.; Demirelli, F.; Serdengecti, S. [Dept. of Internal Medicine, Medical Oncology Section, Istanbul Univ., Cerrahpasa Medical School, Istanbul (Turkey)

    2005-10-01

    Background and purpose: to investigate the role of postoperative concomitant chemoradioimmunotherapy in gastric adenocarcinoma patients. Patients and methods: 59 pateints, who underwent total or subtotal gastrectomy, with lymph node involvement, positive microscopic surgical margins or serosal involvement were included in the study. Radiotherapy started concomitantly with chemotherapy and levamisole. Extended-field radiotherapy was given to gastric bed and regional lymphatics via two anterior-posterior/posterior-anterior fields. A total dose of 45 Gy in 25 fractions with a fraction size of 1.8 Gy was planned. In 28 patients (48%) with positive surgical margins a 10-Gy boost dose was given to the anastomosis site. An adjuvant i.v. bolus of 450 mg/m{sup 2}/day 5-fluorouracil (5-FU) was administered concomitantly during the first 3 days and at the 20th day of irradiation. After completion of radiotherapy, i.v. boluses of 450 mg/m{sup 2}/day 5-FU and 25 mg/m{sup 2}/day rescuvorin were continued for 6 months once a week. Levamisole 40 mg/day orally was started at the 1st day of radiotherapy and also continued for 6 months. Median follow-up was 37 months (7-112 months). Results: median survival was 23 months. Overall 3- and 5-year survival rates amounted to 35% and 14%, respectively. Median survival of the patients with positive surgical margins was 22 months. The 3- and 5-year locoregional control rates were 59% and 55%, respectively. The most common toxicity was upper gastrointestinal system toxicity, which was observed in 42 patients (71%). Four patients (7%) died on account of early toxic effects, and six (10%) could not complete treatment. Conclusion: although 48% of the study population involved patients with microscopic residual disease, the survival results as a whole were satisfactory. However, due to high toxicity, radiotherapy must be delivered with the most proper techniques along with adequate nutrition and supportive care. (orig.)

  16. Two-year results of a prospective, multi-site investigation of patient satisfaction and psychosocial status following cosmetic surgery.

    Science.gov (United States)

    Sarwer, David B; Infield, Alison L; Baker, James L; Casas, Laurie A; Glat, Paul M; Gold, Alan H; Jewell, Mark L; Larossa, Don; Nahai, Foad; Young, V Leroy

    2008-01-01

    The number of cosmetic surgical and nonsurgical procedures performed in the United States has increased by 500% over the past 10 years. Most studies of psychosocial functioning following aesthetic procedures have reported high levels of patient satisfaction and improved functioning; however, nearly all these studies focused only on changes during the first posttreatment year. This paper reports on the 2-year results of a prospective, multi-site investigation of postoperative satisfaction and changes in psychosocial status following cosmetic surgery. One hundred patients from 8 surgical practices completed psychometric measures of body image, depressive symptoms, and self-esteem before surgery. Patients completed the same measures again at 3, 6, 12, and 24 months postoperatively. In addition, they reported their postoperative satisfaction as well as self-rated attractiveness at the 4 postoperative assessment points. Patients reported improvements in their overall appearance and body image, the appearance of and their degree of dissatisfaction with the feature altered by surgery, and the frequency of negative body image emotions in specific social situations through 24 months after surgery. These improvements were first evident at 3 months postoperatively and were maintained, without deterioration, through 2 years following surgery. Patients reported high rates of satisfaction and improvements in body image within the first 3 months of cosmetic surgery. These improvements were well maintained through the first 2 postoperative years.

  17. Overview of NASA FINESSE (Field Investigations to Enable Solar System Science and Exploration) Science and Exploration Results

    Science.gov (United States)

    Heldmann, J. L.; Lim, D. S. S.; Hughes, S. S.; Kobs-Nawotniak, S. E.; Garry, W. B.; Osinski, G. R.; Hodges, K. V.; Kobayashi, L.; Colaprete, A.

    2015-12-01

    NASA's FINESSE (Field Investigations to Enable Solar System Science and Exploration) project is focused on a science and exploration field-based research program to generate strategic knowledge in preparation for human and robotic exploration of other planetary bodies including our moon, Mars' moons Phobos and Deimos, and near-Earth asteroids. Scientific study focuses on planetary volcanism (e.g., the formation of volcanoes, evolution of magma chambers and the formation of multiple lava flow types, as well as the evolution and entrapment of volatile chemicals) and impact cratering (impact rock modification, cratering mechanics, and the chronologic record). FINESSE conducts multiple terrestrial field campaigns (Craters of the Moon National Monument and Preserve in Idaho for volcanics, and West Clearwater Impact Structure in Canada for impact studies) to study such features as analogs relevant to our moon, Phobos, Deimos, and asteroids. Here we present the science and exploration results from two deployments to Idaho (2014, 2015) and our first deployment to Canada (2014). FINESSE was selected as a research team by NASA's Solar System Exploration Research Virtual Institute (SSERVI). SSERVI is a joint effort by NASA's Science Mission Directorate (SMD) and Human Exploration and Operations Mission Directorate (HEOMD).

  18. Effluent treatment by multi-media filtration, microfiltration and ultrafiltration: results of a pilot investigation at WWTP Hoek van Holland.

    Science.gov (United States)

    te Poele, S; Menkveld, W; Boom, J; van Bragt, W

    2005-01-01

    Upgrading of wastewater treatment plant (WWTP) effluent as a part of the Dutch governmental policy to close the water cycle has increasing interest now. The Water Board Hoogheemraadschap van Delfland together with the project team of Witteveen + Bos Consulting Engineers, Delft University of Technology and Rossmark water treatment investigated the reuse possibilities of WWTP effluent in the region of Delfland. Therefore pilot research was carried out at WWTP Hoek van Holland applying different filtration techniques: multi-media filtration, micro- and ultrafiltration. The results show stable process performances of the different filtration techniques when proper pre-treatment was applied. For microfiltration the filtration characteristics were strongly influenced by particles which were not retained in the multi-media filter. For ultrafiltration the filtration characteristics were strongly influenced by organic components WWTP effluent could not be used directly as process water or for agriculture purposes, due to high concentrations of COD and salts in the WWTP effluent and filtrates. However WWTP effluent or floc filtrate could be applied directly as water for the washing of sea-sand.

  19. Can we use digital life-log images to investigate active and sedentary travel behaviour? Results from a pilot study

    Directory of Open Access Journals (Sweden)

    Hodges Steve

    2011-05-01

    Full Text Available Abstract Background Active travel such as walking and cycling has potential to increase physical activity levels in sedentary individuals. Motorised car travel is a sedentary behaviour that contributes to carbon emissions. There have been recent calls for technology that will improve our ability to measure these travel behaviours, and in particular evaluate modes and volumes of active versus sedentary travel. The purpose of this pilot study is to investigate the potential efficacy of a new electronic measurement device, a wearable digital camera called SenseCam, in travel research. Methods Participants (n = 20 were required to wear the SenseCam device for one full day of travel. The device automatically records approximately 3,600 time-stamped, first-person point-of-view images per day, without any action required by the wearer. Participants also completed a self-report travel diary over the same period for comparison, and were interviewed afterwards to assess user burden and experience. Results There were a total of 105 confirmed journeys in this pilot. The new SenseCam device recorded more journeys than the travel diary (99 vs. 94. Although the two measures demonstrated an acceptable correlation for journey duration (r = 0.92, p Conclusions Direct observation of travel behaviour from time-stamped images shows considerable potential in the field of travel research. Journey duration derived from direct observation of travel behaviour from time-stamped images appears to suggest over-reporting of self-reported journey duration.

  20. Results of Paleomagnetic Investigation of Angara - Taseeva Depression and Central Part of Tunguska Syncline (Siberian Trap Province, Russia)

    Science.gov (United States)

    Latyshev, A.; Veselovskiy, R. V.; Pavlov, V.

    2014-12-01

    Results of paleomagnetic investigation of two regions of Siberian Trap province (Angara - Taseeva depression and central part of Tunguska syncline) are performed here. Our work was dedicated to the estimation of dynamics and duration of magmatic activity during Siberian Traps emplacement. The conclusions are based on paleomagnetic study of large dolerite sills in the periphery of Siberian Trap province, tuffaceous deposits, small intrusions and lava flows of Tunguska syncline, and on geochronological data (Ivanov et al., 2013; Reichow et al., 2009). The presented data show that formation of Siberian Traps in these regions took place as several short bursts of magmatic activity led to large sill intrusions and eruptions of tuffs. This data are in agreement with the pulsating character of magmatic activity in the Northern part of Siberian platform (Pavlov et al., 2014). The most powerful burst of magmatic activity in Angara-Taseeva syncline is supposed to be synchronous to the main phase of volcanic eruptions in the Northern part of Siberian platform and emplacement of ore-bearing intrusions in Noril'sk district. This study was funded by grant RFBR # 14-05-31447.

  1. Overview of NASA FINESSE (Field Investigations to Enable Solar System Science and Exploration) Science and Exploration Results

    Science.gov (United States)

    Heldmann, Jennifer L.; Lim, Darlene S. S.; Hughes, S.; Kobs, S.; Garry, B.; Osinski, G. R.; Hodges, K.; Kobayashi, L.; Colaprete, A.

    2015-01-01

    NASA's FINESSE (Field Investigations to Enable Solar System Science and Exploration) project is focused on a science and exploration field-based research program to generate strategic knowledge in preparation for human and robotic exploration of other planetary bodies including our moon, Mars' moons Phobos and Deimos, and near-Earth asteroids. Scientific study focuses on planetary volcanism (e.g., the formation of volcanoes, evolution of magma chambers and the formation of multiple lava flow types, as well as the evolution and entrapment of volatile chemicals) and impact cratering (impact rock modification, cratering mechanics, and the chronologic record). FINESSE conducts multiple terrestrial field campaigns (Craters of the Moon National Monument and Preserve in Idaho for volcanics, and West Clearwater Impact Structure in Canada for impact studies) to study such features as analogs relevant to our moon, Phobos, Deimos, and asteroids. Here we present the science and exploration results from two deployments to Idaho (2014, 2015) and our first deployment to Canada (2014). FINESSE was selected as a research team by NASA's Solar System Exploration Research Virtual Institute (SSERVI). SSERVI is a joint effort by NASA's Science Mission Directorate (SMD) and Human Exploration and Operations Mission Directorate (HEOMD).

  2. Surface-water-quality assessment of the lower Kansas River basin, Kansas and Nebraska; results of investigations, 1987-90

    Science.gov (United States)

    Helgesen, J.O.

    1995-01-01

    Surface-water-quality conditions and trends were assessed in the lower Kansas River Basin, which drains about 15,300 square miles of mainly agricultural land in southeast Nebraska and northeast Kansas. On the basis of established water-quality criteria, most streams in the basin were suitable for uses such as public-water supply, irrigation, and maintenance of aquatic life. However, most concerns identified from a previous analysis of available data through 1986 are substantiated by analysis of data for May 1987 through April 1990. Less-than-normal precipitation and runoff during 1987-90 affected surface-water quality and are important factors in the interpretation of results.Dissolved-solids concentrations in the main stem Kansas River during May 1987 through April 1990 commonly exceeded 500 milligrams per liter, which may be of concern for public-water supplies and for the irrigation of sensitive crops. Large concentrations of chloride in the Kansas River are derived from ground water discharging in the Smoky Hill River Basin west of the study unit. Trends of increasing concentrations of some dissolved major ions were statistically significant in the northwestern part of the study unit, which could reflect substantial increases in irrigated acreage.The largest concentrations of suspended sediment in streams during May 1987 through April 1990 were associated with high-density cropland in areas of little local relief and medium-density irrigated cropland in more dissected areas. The smallest concentrations were measured downstream from large reservoirs and in streams draining areas having little or no row-crop cultivation. Mean annual suspended-sediment transport rates in the main stem Kansas River increased substantially in the downstream direction. No conclusions could be reached concerning the relations of suspended-sediment transport, yields, or trends to natural and human factors.The largest sources of nitrogen and phosphorus in the study unit were fertilizer

  3. The disposition of impact ejecta resulting from the AIDA-DART mission to binary asteroid 65803 Didymos: an independent investigation

    Science.gov (United States)

    Richardson, James E.; O'Brien, David P.

    2016-10-01

    If all goes as planned, in the year 2020 a joint ESA and NASA mission will be launched that will rendezvous with the near-Earth binary asteroid system 65803 Didymos in the fall of 2022. The European component, the Asteroid Impact & Deflection Assessment (AIDA) spacecraft will arrive first and characterize the system, which consists of a ~800 m diameter primary and a ~160 m diameter secondary, orbiting a common center of mass at a semi-major axis distance of ~1200 m with a orbital period of 11.9 hr. Following system characterization, the AIDA spacecraft will remove to a safe distance while the NASA component, the 300 kg Double Asteroid Redirection Test (DART) spacecraft collides with the trailing edge of the secondary body (with respect to the binary's retrograde mutual orbit). Meanwhile, the AIDA spacecraft will conduct observations of this impact and its aftermath, specifically looking for changes made to the primary, the secondary, and their mutual orbit as a result of the DART collision. Of particular interest is the ballistic flight and final disposition of the ejecta produced by the impact cratering process, not just from the standpoint of scientific study, but also from the standpoint of AIDA spacecraft safety.In this study, we investigate a series of hypothetical DART impacts utilizing a semi-empirical, numerical impact ejecta plume model originally developed for the Deep Impact mission and designed specifically with impacts on small bodies in mind. The resulting excavated mass is discretized into 7200 individual tracer particles, each representing a unique combination of speed, mass, and ejected direction. The trajectory of each tracer is computed numerically under the gravitational influence of both primary and secondary, along with the effects of solar radiation pressure. Each tracer is followed until it either impacts a body or escapes the system, whereupon tracking is continued in the heliocentric frame using an N-body integrator. Various impact

  4. Placental complications after a previous cesarean section

    OpenAIRE

    Milošević Jelena; Lilić Vekoslav; Tasić Marija; Radović-Janošević Dragana; Stefanović Milan; Antić Vladimir

    2009-01-01

    Introduction The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complic...

  5. Internal structural changes in keratin fibres resulting from combined hair waving and stress relaxation treatments: a Raman spectroscopic investigation.

    Science.gov (United States)

    Kuzuhara, A

    2016-04-01

    The objective of our research was to investigate the influence of chemical treatments (reduction, stress relaxation and oxidation) on hair keratin fibres. The structure of cross-sections at various depths of virgin white human hair resulting from permanent waving treatments with stress relaxation process was directly analysed at a molecular level using Raman spectroscopy. In particular, the three disulphide (-SS-) conformations in human hair were compared by S-S band analysis. The gauche-gauche-gauche (GGG) and gauche-gauche-trans (GGT) contents of -SS- groups remarkably decreased, while the trans-gauche-trans (TGT) content was not changed by performing the reduction process with thioglycolic acid. In addition, the high-temperature stress relaxation process after reduction accelerated the disconnection of -SS- (GGG and GGT) groups in the human hair, while the low-temperature stress relaxation process after reduction accelerated the reconnection of -SS- (GGG and GGT) groups. Moreover, the S-O band intensity at 1042 cm(-1) , assigned to cysteic acid, existing in the cuticle region and the surface of the cortex region increased, while the GGG content significantly decreased by performing the oxidation process after the reduction and the high-temperature stress relaxation processes. The author concluded that the high-temperature relaxation process after reduction accelerated the disconnection of -SS- (GGG and GGT) groups, thereby leading to the remarkable local molecular disorganization (an increase in the cysteic acid content and a decrease in the GGG content) on the cuticle and cortex cells during the oxidation process. © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  6. Final report : results of the 2007 investigation of potential contamination at the former CCC/USDA facility in Powhattan, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2008-08-15

    The 2007 investigation of carbon tetrachloride and chloroform contamination at Powhattan, Kansas, was conducted at the request of the Kansas Department of Health and Environment (KDHE 2006a). The Environmental Science Division of Argonne National Laboratory implemented the investigation on behalf of the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA). The primary purposes of the investigation were to evaluate potential contaminant source areas on the former CCC/USDA property, determine the horizontal and vertical extent of potential contamination, conduct groundwater monitoring, and provide recommendations for future action.

  7. Recent Results of the Investigation of a Microfluidic Sampling Chip and Sampling System for Hot Cell Aqueous Processing Streams

    Energy Technology Data Exchange (ETDEWEB)

    Julia Tripp; Jack Law; Tara Smith

    2013-10-01

    A Fuel Cycle Research and Development project has investigated an innovative sampling method that could evolve into the next generation sampling and analysis system for metallic elements present in aqueous processing streams. Initially sampling technologies were evaluated and microfluidics sampling chip technology was selected and tested. A conceptual design for a fully automated microcapillary-based system was completed and a robotic automated sampling system was fabricated. The mechanical and sampling operation of the completed sampling system was investigated. In addition, the production of a less expensive, mass produced sampling chip was investigated to avoid chip reuse thus increasing sampling reproducibility/accuracy. The microfluidic-based robotic sampling system’s mechanical elements were tested to ensure analytical reproducibility and the optimum robotic handling of microfluidic sampling chips.

  8. Dietary fat intake and subsequent weight change in adults: results from the European Prospective Investigation into Cancer and Nutrition cohorts

    DEFF Research Database (Denmark)

    Forouhi, Nita G; Sharp, Stephen J; Du, Huaidong

    2009-01-01

    weight divided by duration of follow-up). DESIGN: We analyzed data from 89,432 men and women from 6 cohorts of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Using country-specific food-frequency questionnaires, we examined the association between baseline fat intake...

  9. Results of infertility investigations and follow-up among 312 infertile women and their partners in Kigali, Rwanda

    NARCIS (Netherlands)

    Dhont, Nathalie; van de Wijgert, Janneke; Vyankandondera, Joseph; Busasa, Rosette; Gasarabwe, Ammiel; Temmerman, Marleen

    2011-01-01

    The objectives of this study were to assess the outcome of infertility investigations and an 18-month follow-up of 312 infertile women and their partners in Rwanda. Between November 2007 and May 2009, an infertility research clinic was opened. Infertile couples received basic infertility

  10. Bell Labs fires physicist for faking research data. Investigators say Schon changed results without knowledge of coworkers

    CERN Multimedia

    Stroh, M

    2002-01-01

    In one of the most serious cases of scientific misconduct, Jan Hendrik Schon, a star researcher at Bell Laboratories in New Jersey, was fired yesterday after investigators determined he fabricated data in numerous high-profile papers (1/2 page).

  11. A Pilot Study Investigating the Effects of Advanced Nuclear Power Plant Control Room Technologies: Methods and Qualitative Results

    Energy Technology Data Exchange (ETDEWEB)

    BLanc, Katya Le [Idaho National Lab. (INL), Idaho Falls, ID (United States); Powers, David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Joe, Jeffrey [Idaho National Lab. (INL), Idaho Falls, ID (United States); Spielman, Zachary [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rice, Brandon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Fitzgerald, Kirk [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-08-01

    Control room modernization is an important part of life extension for the existing light water reactor fleet. None of the 99 currently operating commercial nuclear power plants in the U.S. has completed a full-scale control room modernization to date. Nuclear power plant main control rooms for the existing commercial reactor fleet remain significantly analog, with only limited digital modernizations. Upgrades in the U.S. do not achieve the full potential of newer technologies that might otherwise enhance plant and operator performance. The goal of the control room upgrade benefits research is to identify previously overlooked benefits of modernization, identify candidate technologies that may facilitate such benefits, and demonstrate these technologies through human factors research. This report describes a pilot study to test upgrades to the Human Systems Simulation Laboratory at INL.

  12. Clinical performance of a new magnetic bone conduction hearing implant system: results from a prospective, multicenter, clinical investigation.

    Science.gov (United States)

    Briggs, Robert; Van Hasselt, Andrew; Luntz, Michal; Goycoolea, Marcos; Wigren, Stina; Weber, Peter; Smeds, Henrik; Flynn, Mark; Cowan, Robert

    2015-06-01

    The aim of the investigation was to prospectively evaluate, in a multicenter setting, the clinical performance of a new magnetic bone conduction hearing implant system. The test device was the Cochlear Baha Attract System (Cochlear Bone Anchored Solutions AB, Mölnlycke, Sweden). Instead of the skin-penetrating abutment of traditional bone conduction hearing implants, the test device uses an implantable and an external magnet to transmit sound from the sound processor (SP) through intact skin to the skull bone. Twenty-seven adult patients with a conductive or mild mixed hearing loss or single-sided sensorineural deafness were included in the clinical investigation across four investigational sites. The patients were followed for 9 months after implantation. The study evaluated efficacy in terms of hearing performance compared with unaided hearing and with hearing with the SP on a softband. Patient benefit, soft tissue status, device retention, and safety parameters were monitored continuously throughout the investigation. Surgery and healing was uneventful. Statistically significant improvements in audibility and speech understanding in noise and quiet were recorded for the test device compared with preoperative unaided hearing. Speech recognition was similar or better than tests performed with the same SP on a softband. Good soft tissue outcomes were reported, without major pressure-related complications. At the end of the investigation, all patients continued to use and benefit from the device. The test device provides good hearing performance in patients with a conductive hearing loss or single-sided sensorineural deafness, with good wearing comfort and minimal soft tissue complications.

  13. Automatic electromagnetic valve for previous vacuum

    International Nuclear Information System (INIS)

    Granados, C. E.; Martin, F.

    1959-01-01

    A valve which permits the maintenance of an installation vacuum when electric current fails is described. It also lets the air in the previous vacuum bomb to prevent the oil ascending in the vacuum tubes. (Author)

  14. Is Previous Respiratory Disease a Risk Factor for Lung Cancer?

    Science.gov (United States)

    Denholm, Rachel; Schüz, Joachim; Straif, Kurt; Stücker, Isabelle; Jöckel, Karl-Heinz; Brenner, Darren R.; De Matteis, Sara; Boffetta, Paolo; Guida, Florence; Brüske, Irene; Wichmann, Heinz-Erich; Landi, Maria Teresa; Caporaso, Neil; Siemiatycki, Jack; Ahrens, Wolfgang; Pohlabeln, Hermann; Zaridze, David; Field, John K.; McLaughlin, John; Demers, Paul; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Dumitru, Rodica Stanescu; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Kendzia, Benjamin; Peters, Susan; Behrens, Thomas; Vermeulen, Roel; Brüning, Thomas; Kromhout, Hans

    2014-01-01

    Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia, and asthma. Methods: The SYNERGY project pooled information on previous respiratory diseases from 12,739 case subjects and 14,945 control subjects from 7 case–control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, center, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years, and time since quitting smoking. Measurements and Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (e.g., in men: odds ratio [OR], 1.33; 95% confidence interval [CI], 1.20–1.48 and OR, 1.50; 95% CI, 1.21–1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 years or less before lung cancer (OR, 3.31; 95% CI, 2.33–4.70 for men), but not longer. Co-occurrence of chronic bronchitis and emphysema and/or pneumonia had a stronger positive association with lung cancer than chronic bronchitis “only.” Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 years or more before lung cancer compared with shorter. Conclusions: Findings from this large international case–control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. PMID:25054566

  15. Aespoe HRL - Geoscientific evaluation 1997/2. Results from pre-investigation and detailed site characterization. Summary report

    Energy Technology Data Exchange (ETDEWEB)

    Rhen, I. [VBB Viak, Goeteborg (Sweden); Baeckbom, G. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)] [eds.; Gustafsson, Gunnar [VBB Viak, Goeteborg (Sweden) and Chalmers Univ. of Technology, Goeteborg (Sweden); Stanfors, R. [RS Consulting, Lund (Sweden); Wikberg, P. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden)

    1997-05-01

    The work at Aespoe Hard rock laboratory provides an important scientific and technical basis for implementing and operating a future deep repository in Sweden. A milestone has now been reached with the completion of the pre investigation and construction phases at Aespoe HRL. The present data base at Aespoe HRL is one of the most comprehensive data bases in the world for crystalline rock properties, containing data from a large number of investigation methods from the surface down to 1700 m below ground level. Site characterization in conjunction with construction work has basically confirmed the pre-construction models. The site characterization has been a realistic `dress rehearsal` that is invaluable for planning and execution of surface and underground characterization of sites for the deep repository for spent nuclear fuel in Sweden. 502 refs, 114 figs, 30 tabs.

  16. Aespoe HRL - Geoscientific evaluation 1997/2. Results from pre-investigation and detailed site characterization. Summary report

    International Nuclear Information System (INIS)

    Rhen, I.; Baeckbom, G.; Stanfors, R.; Wikberg, P.

    1997-05-01

    The work at Aespoe Hard rock laboratory provides an important scientific and technical basis for implementing and operating a future deep repository in Sweden. A milestone has now been reached with the completion of the pre investigation and construction phases at Aespoe HRL. The present data base at Aespoe HRL is one of the most comprehensive data bases in the world for crystalline rock properties, containing data from a large number of investigation methods from the surface down to 1700 m below ground level. Site characterization in conjunction with construction work has basically confirmed the pre-construction models. The site characterization has been a realistic 'dress rehearsal' that is invaluable for planning and execution of surface and underground characterization of sites for the deep repository for spent nuclear fuel in Sweden

  17. An Ongoing Investigation of Science Literacy: Results of a 22-Year Study Probing Students' Knowledge and Attitude Towards Science

    Science.gov (United States)

    Impey, C.; Buxner, S.; Antonellis, J.; CATS

    2013-04-01

    This talk presents findings related to our ongoing work investigating students' knowledge and attitudes towards science and technology. We present an overview of research studies and findings including a comparison of the science literacy measures of University of Arizona students compared to national studies, conceptions related to astrology, views of radiation, and students' pseudoscience and religious beliefs. We discuss implications for instructors and researchers interested in improving students' science literacy scores and diagnosing alternative beliefs.

  18. Investigations on alternative substances for control of apple scab - Results from Conidia germinating tests and experiments with plant extracts

    OpenAIRE

    Pfeiffer, B.; Alt, S.; Schulz, C.; Hein, B.; Kollar, A.

    2004-01-01

    The intention of this research project, which was supported within the "Bundesprogramm Ökologischer Landbau", was to find alternatives for the control of Venturia inaequalis for the organic fruitgrower. Beside the investigations on reducing the ascospore potential on fallen leaves, experiments were conducted in laboratory, greenhouses and in orchard to test direct control of scab with different plant extracts, concentrations and methods of extraction. Extracts from Inula viscosa, ...

  19. The U.S. Government Technical Report and Aerospace Knowledge Diffusion : Results of an On-Going Investigation

    OpenAIRE

    Pinelli, Thomas E. (NASA Langley Research Center); Khan, A.R. (NTIS); Barclay, R.O. (Rensselaer Polytechnic Institute); Kennedy, J.M. (Indiana University); GreyNet, Grey Literature Network Service

    1994-01-01

    This paper contains descriptive and analytical data concerning the U.S. government technical report. These data were collected as part of an on-going investigation directed toward understanding the transfer of federally funded aerospace research and development (R&D). The paper summarizes current literature and research, discusses U.S. government technical report use, and presents data obtained from the Aerospace Knowledge Diffusion Research Project. U.A. aerospace engineers and scientists us...

  20. Correlates of joint child protection and police child sexual abuse investigations: results from the Canadian Incidence Study of Reported Child Abuse and Neglect-2008

    Directory of Open Access Journals (Sweden)

    L. Tonmyr

    2015-01-01

    Full Text Available Introduction: Our study examines the frequency of joint investigations by child protection workers and the police in sexual abuse investigations compared to other maltreatment types and the association of child-, caregiver-, maltreatment- and investigation-related characteristics in joint investigations, focussing specifically on investigations involving sexual abuse. Methods: We analyzed data from the Canadian Incidence Study of Reported Child Abuse and Neglect-2008 using logistic regression. Results: The data suggest that sexual abuse (55%, and then physical abuse, neglect and emotional maltreatment, are most often co-investigated. Substantiation of maltreatment, severity of maltreatment, placement in out-of-home care, child welfare court involvement and referral of a family member to specialized services was more likely when the police were involved in an investigation. Conclusion: This study adds to the limited information on correlates of joint child protection agency and police investigations. Further research is needed to determine the effectiveness of these joint investigations.

  1. Results of investigation of muon fluxes of superhigh energy cosmic rays with X-ray emulsion chambers

    Science.gov (United States)

    Ivanenko, I. P.; Ivanova, M. A.; Kuzmichev, L. A.; Ilyina, N. P.; Mandritskaya, K. V.; Osipova, E. A.; Rakobolskaya, I. V.; Zatsepin, G. T.

    1985-01-01

    The overall data from the investigation of the cosmic ray muon flux in the range of zenith angles (0-90) deg within the energy range (3.5 to 5.0) TeV is presented. The exposure of large X-ray emulsion chambers underground was 1200 tons. year. The data were processe using the method which was applied in the experiment Pamir and differred from the earlier applied one. The obtained value of a slope power index of the differential energy spectrum of the global muon flux is =3.7 that corresponds to the slope of the pion generation differential spectrum, gamma sub PI = 2.75 + or - .04. The analysis of the muon zenith-angular distribution showed that the contribution of rapid generation muons in the total muon flux agree the best with the value .2% and less with .7% at a 90% reliability level.

  2. How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium.

    Science.gov (United States)

    Wirrell, Elaine C; Shellhaas, Renée A; Joshi, Charuta; Keator, Cynthia; Kumar, Shilpi; Mitchell, Wendy G

    2015-04-01

    To prospectively evaluate the etiology of new-onset infantile spasms and evaluate the yield of genetic and metabolic investigations in those without obvious cause after initial clinical evaluation and magnetic resonance imaging (MRI). Twenty-one U.S. pediatric epilepsy centers prospectively enrolled infants with newly diagnosed West syndrome in a central database. Etiology and investigations performed within 3 months of diagnosis were documented. From June 2012 to June 2014, a total of 251 infants were enrolled (53% male). A cause was identified in 161 (64.4%) of 250 cases (genetic,14.4%; genetic-structural, 10.0%; structural-congenital, 10.8%; structural-acquired, 22.4%; metabolic, 4.8%; and infectious, 2.0%). An obvious cause was found after initial clinical assessment (history and physical examination) and/or MRI in 138 of 161, whereas further genetic and metabolic studies were revealing in another 23 cases. Of 112 subjects without an obvious cause after initial evaluation and MRI, 81 (72.3%) had undergone genetic testing, which showed a causal abnormality in 23.5% and a variant of unknown significance in 14.8%. Although metabolic studies were done in the majority (serum, 79.5%; urine, 69.6%; and cerebrospinal fluid [CSF], 38.4%), these revealed an etiology in only five cases (4.5%). No correlation was found between type of health insurance (public vs. private) and either genetic or metabolic testing. Clinical evaluation and MRI provide a specific diagnosis in 55% of children presenting with West syndrome. We propose that a cost-effective workup for those without obvious cause after initial clinical evaluation and MRI includes an array comparative genomic hybridization (aCGH) followed by an epilepsy gene panel if the microarray is not definitive, serum lactate, serum amino acids, and urine organic acids. Wiley Periodicals, Inc. © 2015 International League Against Epilepsy.

  3. INTRODUCTION Previous reports have documented a high ...

    African Journals Online (AJOL)

    pregnancy if they were married, educated, had dental insurance, previously used dental services when not pregnant, or had knowledge about the possible connection between oral health and pregnancy outcome8. The purpose of this study was to explore the factors determining good oral hygiene among pregnant women ...

  4. Empowerment perceptions of educational managers from previously ...

    African Journals Online (AJOL)

    The perceptions of educational manag ers from previously disadvantaged primary and high schools in the Nelson Mandela Metropole regarding the issue of empowerment are outlined and the perceptions of educational managers in terms of various aspects of empowerment at different levels reflected. A literature study ...

  5. Management of choledocholithiasis after previous gastrectomy.

    Science.gov (United States)

    Anwer, S; Egan, R; Cross, N; Guru Naidu, S; Somasekar, K

    2017-09-01

    Common bile duct stones in patients with a previous gastrectomy can be a technical challenge because of the altered anatomy. This paper presents the successful management of two such patients using non-traditional techniques as conventional endoscopic retrograde cholangiopancreatography was not possible.

  6. Laboratory Grouping Based on Previous Courses.

    Science.gov (United States)

    Doemling, Donald B.; Bowman, Douglas C.

    1981-01-01

    In a five-year study, second-year human physiology students were grouped for laboratory according to previous physiology and laboratory experience. No significant differences in course or board examination performance were found, though correlations were found between predental grade-point averages and grouping. (MSE)

  7. Results of instrumented posterolateral fusion in treatment of lumbar spondylolisthesis with and without segmental kyphosis: A retrospective investigation

    Directory of Open Access Journals (Sweden)

    Szu-Yuan Chen

    2015-06-01

    Full Text Available Background: Treatment by posterolateral fusion (PLF with pedicle-screw instrumentation can be unsuccessful in one-segment and low-grade lumbar spondylolisthesis. Segmental kyphosis, either rigid or dynamic, was hypothesized to be one of the factors interfering with the fusion results. Methods: From 2004 to 2005, 239 patients with single-segment and low-grade spondylolisthesis were recruited and divided into two groups: Group 1 consisting of 129 patients without segmental kyphosis and group 2 consisting of 110 patients with segmental kyphosis. All patients underwent instrumented PLF at the same medical institute, and the average follow-up period was 31 ± 19 months. We obtained plain radiographs of the lumbosacral spine with the anteroposterior view, the lateral view, and the dynamic flexion-extension views before the operation and during the follow-ups. The results of PLF in the two groups were then compared. Results: There was no significant difference in the demographic data of the two groups, except for gender distribution. The osseous fusion rates were 90.7% in group 1 and 68.2% in group 2 (p < 0.001. Conclusion: Instrumented PLF resulted in significantly higher osseous fusion rate in patients without segmental kyphosis than in the patients with segmental kyphosis. For the patients with sagittal imbalance, such as rigid or dynamic kyphosis, pedicle-screw fixation cannot ensure successful PLF. Interbody fusion by the posterior lumbar interbody fusion or transforaminal lumbar interbody fusion technique might help overcome this problem.

  8. Development of a wind energy converter and investigation of its operational function. Part 4: Test setup and results of measurement

    Science.gov (United States)

    Armbrust, S.; Molly, J. P.

    1982-12-01

    Measurements made during test operations at the MODA.10 plant as well as at a 25 years old 6 kW wind energy converter are presented. The test arrangements, measurement results of both wind energy converters, and the experience gained are described.

  9. Wild medicinal and food plants used by communities living in Mopane woodlands of southern Angola: Results of an ethnobotanical field investigation.

    Science.gov (United States)

    Urso, Valeria; Signorini, Maria Adele; Tonini, Matteo; Bruschi, Piero

    2016-01-11

    diseases (25, 54). The highest values of FIC were recorded for body care (FIC=1.0), circulatory diseases (FIC=0.91), malaria (FIC=0.81) and digestive disorders (FIC=0.55). The plants showing the highest informants' consensus (FL) were Myrothamnus flabellifolia used to treat colds and respiratory diseases (FL=100%), Terminalia prunioides for digestive diseases (93%) and Euphorbia subsalsa for backache (86%). For five plants cited as medicinal by the informants, no reports were found in the consulted ethnobotanical and ethnopharmacological literature; many uses of several already known medicinal plants were also unrecorded. Food products obtained from wild plants include fresh fruit (20 ethnospecies, 287 citations), alcoholic (11, 107) and non-alcoholic (10, 44) beverages, massa, i.e. a kind of mash, (4, 65), vegetables (10, 40), and others. Results show that people living in Mopane communities of southern Angola hold a valuable knowledge of the uses of plant resources and that some of the plants cited by the informants represent an important component of the local livelihood strategies. We also found some plants worthy of more in-depth investigations on their possible pharmacological activity, including: (i) those used to treat diseases which reached the highest FIC, like malaria and various disorders of the gastrointestinal tract; (ii) plants with a high FL; (iii) plants not previously reported in ethnomedical literature, especially those cited by different informants; (iv) plants with possible nutraceutical or pharma-food properties, i.e. plants with considerable contents in vitamins and/or micronutrients and plants whose food and medicinal uses are closely related. Anthropological and historical studies in ethnopharmacology, quality traditional medicines. Botany, Traditional medicine, Africa, Diarrhea, Malaria. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  10. Alterations in autonomic tone during trauma exposure using eye movement desensitization and reprocessing (EMDR)--results of a preliminary investigation.

    Science.gov (United States)

    Sack, Martin; Lempa, Wolfgang; Steinmetz, Adrian; Lamprecht, Friedhelm; Hofmann, Arne

    2008-10-01

    EMDR combines stimuli that evoke divided attention--e.g. eye movements--with exposure to traumatic memories. Our objective was to investigate psycho-physiological correlates of EMDR during treatment sessions. A total of 55 treatment sessions from 10 patients with PTSD was monitored applying impedance cardiography. Onset of every stimulation/exposure period (n=811) was marked and effects within and across stimulation sets on heart rate (HR), heart rate variability (HRV), pre-ejection period (PEP) and respiration rate were examined. At stimulation onsets a sharp increase of HRV and a significant decrease of HR was noticed indicating de-arousal. During ongoing stimulation, PEP and HRV decreased significantly while respiration rate significantly increased, indicating stress-related arousal. However, across entire sessions a significant decrease of psycho-physiological activity was noticed, evidenced by progressively decreasing HR and increasing HRV. These findings suggest that EMDR is associated with patterns of autonomic activity associated with substantial psycho-physiological de-arousal over time.

  11. Tree Death Not Resulting in Gap Creation: An Investigation of Canopy Dynamics of Northern Temperate Deciduous Forests

    Directory of Open Access Journals (Sweden)

    Jean-Francois Senécal

    2018-01-01

    Full Text Available Several decades of research have shown that canopy gaps drive tree renewal processes in the temperate deciduous forest biome. In the literature, canopy gaps are usually defined as canopy openings that are created by partial or total tree death of one or more canopy trees. In this study, we investigate linkages between tree damage mechanisms and the formation or not of new canopy gaps in northern temperate deciduous forests. We studied height loss processes in unmanaged and managed forests recovering from partial cutting with multi-temporal airborne Lidar data. The Lidar dataset was used to detect areas where canopy height reduction occurred, which were then field-studied to identify the tree damage mechanisms implicated. We also sampled the density of leaf material along transects to characterize canopy structure. We used the dataset of the canopy height reduction areas in a multi-model inference analysis to determine whether canopy structures or tree damage mechanisms most influenced the creation of new canopy gaps within canopy height reduction areas. According to our model, new canopy gaps are created mainly when canopy damage enlarges existing gaps or when height is reduced over areas without an already established dense sub-canopy tree layer.

  12. Investigating the composition of organic aerosol resulting from cyclohexene ozonolysis: low molecular weight and heterogeneous reaction products

    Directory of Open Access Journals (Sweden)

    J. F. Hamilton

    2006-01-01

    Full Text Available The composition of organic aerosol formed from the gas phase ozonolysis of cyclohexene has been investigated in a smog chamber experiment. Comprehensive gas chromatography with time of flight mass spectrometric detection was used to determine that dicarboxylic acids and corresponding cyclic anhydrides dominated the small gas phase reaction products found in aerosol sampled during the first hour after initial aerosol formation. Structural analysis of larger more polar molecules was performed using liquid chromatography with ion trap tandem mass spectrometry. This indicated that the majority of identified organic mass was in dimer form, built up from combinations of the most abundant small acid molecules, with frequent indication of the inclusion of adipic acid. Trimers and tetramers potentially formed via similar acid combinations were also observed in lower abundances. Tandem mass spectral data indicated dimers with either acid anhydride or ester functionalities as the linkage between monomers. High-resolution mass spectrometry identified the molecular formulae of the most abundant dimer species to be C10H16O6, C11H18O6, C10H14O8 and C11H16O8 and could be used in some cases to reduce uncertainty in exact chemical structure determination by tandem MS.

  13. High-resolution Fourier diffractometers at the WWR-M reactor: method development and results of structural investigations

    International Nuclear Information System (INIS)

    Trunov, V.A.

    1997-01-01

    In paper detail information of the development and construction of the efficient neutron high resolution diffractometer with using of original version of Fourier method - reverse time-of-flight Fourier method - are presented. The advantages of dignities of method are demonstrated by help of numeral structural studies (rare-earth formates, hexaborides, high-Tc superconductors, catalyses). The part of the scientific results are presented for the first time

  14. Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk.

    Science.gov (United States)

    Zuo, Hui; Ueland, Per M; Midttun, Øivind; Vollset, Stein E; Tell, Grethe S; Theofylaktopoulou, Despoina; Travis, Ruth C; Boutron-Ruault, Marie-Christine; Fournier, Agnès; Severi, Gianluca; Kvaskoff, Marina; Boeing, Heiner; Bergmann, Manuela M; Fortner, Renée T; Kaaks, Rudolf; Trichopoulou, Antonia; Kotanidou, Anastasia; Lagiou, Pagona; Palli, Domenico; Sieri, Sabina; Panico, Salvatore; Bueno-de-Mesquita, H Bas; Peeters, Petra H; Grankvist, Kjell; Johansson, Mikael; Agudo, Antonio; Garcia, Jose Ramon Quiros; Larranaga, Nerea; Sanchez, Maria-Jose; Chirlaque, Maria Dolores; Ardanaz, Eva; Chuang, Shu-Chun; Gallo, Valentina; Brennan, Paul; Johansson, Mattias; Ulvik, Arve

    2018-01-01

    Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1,748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake of vegetables and fruits and physical activity did not materially affect risk association. The association of PAr with lung cancer risk was similar in both genders but slightly stronger in former smokers and in participants diagnosed with squamous cell carcinoma. This study provides robust evidence that increased vitamin B6 catabolism is independently associated with a higher risk of future lung cancer. Significance: This large cohort study firmly establishes an association between an index of vitamin B6 levels with lung cancer risk. Cancer Res; 78(1); 302-8. ©2017 AACR . ©2017 American Association for Cancer Research.

  15. Very late complications of cervical arthroplasty: results of 2 controlled randomized prospective studies from a single investigator site.

    Science.gov (United States)

    Hacker, Francis M; Babcock, Rebecca M; Hacker, Robert J

    2013-12-15

    Prospective, single-site, randomized, Food and Drug Administration-approved investigational device exemption clinical trials of 2 cervical arthroplasty (CA) devices. To evaluate complications with CA occurring more than 4 years after the surgical procedure in Food and Drug Administration clinical trials of the Bryan and Prestige LP arthroplasty devices. Reports of several randomized clinical studies have shown CA to be a safe and effective alternative to anterior cervical fusion in the treatment of degenerative cervical disc disorders. A majority include follow-up intervals of 4 years or less. Between 2002 and 2006, 94 patients were enrolled in Food and Drug Administration studies of the Bryan and Prestige LP cervical disc devices. Charts, imaging studies, and hospital records were reviewed for those who underwent arthroplasty and returned more than 4 years after their surgical procedure with neck-related pain or dysfunction. Excluding adjacent segment disease that occurred with a similar rate for patients who underwent fusion and arthroplasty, 5 patients, all treated with arthroplasty, returned for evaluation of neck and arm symptoms between 48 and 72 months after surgery. Four patients had peridevice vertebral body bone loss. One patient had posterior device migration and presented with myelopathy. Three required revision surgery and 2 were observed. Four patients maintained follow-up and reported stabilization or improvement in symptoms. Despite their similarities, CA and fusion are not equivalent procedures in this study in regard to very late complications. Similar to large joint arthroplasty, delayed device-related complications may occur with CA. These complications commenced well beyond the time frame for complications associated with more traditional cervical spine procedures. Both patients and surgeons should be aware of the potential for very late device-related complications occurring with CA and the need for revision surgery. 1.

  16. Out-of-pile and in-pile temperature noise investigations: a survey of methods results and models

    International Nuclear Information System (INIS)

    Dentico, G.; Giovannini, R.; Marseguerra, M.; Pacilio, N.; Taglienti, S.; Tosi, V.; Vigo, A.; Oguma, R.

    1982-01-01

    A review is given of the main results obtained from temperature noise measurements performed in out-of-pile sodium loops on fast fuel element mock-ups. Sources of data were thermocouples placed in the central axis of the channel downstream from the bundle end. Autoregressive moving average (ARMA) models have been applied to several temperature time series; the analysis shows that a simple ARMA (3, 2) model adequately accounts for the observed fluctuations. Finally, highlights of a heat transfer stochastic model are also reported together with a preliminary validation against in-pile experimental data. (author)

  17. Internet Use and Access, Behavior, Cyberbullying, and Grooming: Results of an Investigative Whole City Survey of Adolescents.

    Science.gov (United States)

    Vismara, Marco Flavio Michele; Toaff, Joseph; Pulvirenti, Giuliana; Settanni, Chiara; Colao, Emma; Lavano, Serena Marianna; Cemicetti, Riccardo; Cotugno, David; Perrotti, Giuseppe; Meschesi, Viviana; Montera, Roberto; Zepponi, Barbara; Rapetto, Umberto; Marotta, Rosa

    2017-08-29

    According to the Digital Agenda for Europe, the way children use the Internet and mobile technologies has changed dramatically in the past years. The aims of this study were to: (1) breakdown the modalities of access and use of the Internet by teenagers to assess risks and risky behaviors; and (2) provide scientific data to evaluate and counsel safe use of the Internet and new technologies by teenagers. The study was conducted under the program "Strategies for a Better Internet for Children" started in May 2012 by the European Commission. It represents the main result of the project launched by Telecom Italia, "Anche io ho qualcosa da dire" (I too have something to say), thanks to which many contributions were collected and used to develop a survey. The questionnaire was structured in 45 questions, covering three macro areas of interest. It was approved by the Department Board at University of Magna Graecia's School of Medicine. After authorization from the regional high school authority, it was administered to all 1534 students (aged 13-19 years) in the city of Catanzaro, Italy. The data was broken down into three main groups: (1) describing education and access to the Internet; (2) methods of use and social networking; and (3) perception and evaluation of risk and risky behaviors. Among noteworthy results in the first group, we can mention that the average age of first contact with information technologies was around 9 years. Moreover, 78.87% (1210/1534) of the interviewed students reported having access to a smartphone or a tablet. Among the results of the second group, we found that the most used social networks were Facebook (85.78%, 1316/1534), YouTube (61.14%, 938/1534), and Google+ (51.56%, 791/1534). About 71.31% (1094/1534) of the interviewed teenagers use their name and surname on social networks, and 40.09% (615/1534) of them knew all their Facebook contacts personally. Among the results of the third group, we found that 7.69% (118/1534) of the

  18. [Placental complications after a previous cesarean section].

    Science.gov (United States)

    Milosević, Jelena; Lilić, Vekoslav; Tasić, Marija; Radović-Janosević, Dragana; Stefanović, Milan; Antić, Vladimir

    2009-01-01

    The incidence of cesarean section has been rising in the past 50 years. With the increased number of cesarean sections, the number of pregnancies with the previous cesarean section rises as well. The aim of this study was to establish the influence of the previous cesarean section on the development of placental complications: placenta previa, placental abruption and placenta accreta, as well as to determine the influence of the number of previous cesarean sections on the complication development. The research was conducted at the Clinic of Gynecology and Obstetrics in Nis covering 10-year-period (from 1995 to 2005) with 32358 deliveries, 1280 deliveries after a previous cesarean section, 131 cases of placenta previa and 118 cases of placental abruption. The experimental groups was presented by the cases of placenta previa or placental abruption with prior cesarean section in obstetrics history, opposite to the control group having the same conditions but without a cesarean section in medical history. The incidence of placenta previa in the control group was 0.33%, opposite to the 1.86% incidence after one cesarean section (pcesarean sections and as high as 14.28% after three cesarean sections in obstetric history. Placental abruption was recorded as placental complication in 0.33% pregnancies in the control group, while its incidence was 1.02% after one cesarean section (pcesarean sections. The difference in the incidence of intrapartal hysterectomy between the group with prior cesarean section (0.86%) and without it (0.006%) shows a high statistical significance (pcesarean section is an important risk factor for the development of placental complications.

  19. An Investigation Of The Influence Of Leadership And Processes On Basic Performance Results Using A Decision Model Based On Efqm

    Directory of Open Access Journals (Sweden)

    Ahmet Talat İnan

    2013-06-01

    Full Text Available EFQM Excellence Model is a quality approach that companies benefit in achieving success. EFQM Excellence Model is an assessment tool helping to determine what is competence and missing aspects in achieving excellence.In this study, based on the EFQM Excellence Model, the influence of basic performance results caused by leadership and processes variables in this model of a firm engaged in maintenance and repair services due to a large-scale company. In this work, a survey was conducted that covering the company's employees and managers. The data obtained from this survey was utilized by using SPSS16.0 statistics software in respect of factor analysis, reliability analysis, correlation and regression analysis. The relation between variables was evaluated taking into account the resuşts of analysis.

  20. Language, memory, and verbal fluency changes in patients with aneurysmal subarachnoid hemorrhage: results of a preoperative investigation.

    Science.gov (United States)

    Vieira, Ana Cláudia C; Azevedo-Filho, Hildo R C; Quinino, Saul; Ponte de Souza, Moysés Loyola; Câmara, Divaldo; Leitão, Laécio; Andrade, Gustavo

    2011-01-01

    To detect changes in speech, verbal fluency, and memory in patients with subarachnoid hemorrhage (SAH) caused by ruptured aneurysms and to analyze the results before surgical or embolization procedure. During the period May 2007 to November 2009, 193 patients with anterior aneurysmal SAH admitted to the Department of Neurosurgery, Hospital da Restauração, Recife, Brazil, were tested for speech, verbal fluency, and memory disturbances after the first week of bleeding and compared with a control group with similar demographics. Patients with aneurysmal SAH differed significantly from the control group in language, verbal fluency, and memory functions before clipping or coiling procedures. There were differences in cognitive performance between patients with different aneurysm sites. It was possible to characterize the cognitive impairments of each area affected early on in the preoperative period, confirming the assumptions that the aneurysm site could be a determining factor of cognitive impairment. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. The power of cooperative investigation: summary and comparison of the HUPO Brain Proteome Project pilot study results.

    Science.gov (United States)

    Reidegeld, Kai A; Müller, Michael; Stephan, Christian; Blüggel, Martin; Hamacher, Michael; Martens, Lennart; Körting, Gerhard; Chamrad, Daniel C; Parkinson, David; Apweiler, Rolf; Meyer, Helmut E; Marcus, Katrin

    2006-09-01

    Within the pilot phase of the HUPO Brain Proteome Project, nine participating laboratories analysed human (epilepsy and/or post mortem material) and mouse brain samples (embryonic, juvenile and adult), respectively, using a variety of different state of the art techniques. Thirty-seven different analytical approaches were accomplished. Of these analyses, 17 were done differentially, i.e. the protein expression patterns of the different samples (human or mouse) were compared. A catalogue of all proteins present in the respective sample was built in 20 analyses (mapping). All data were collected in the Data Collection Center in Bochum, Germany, and were reprocessed according to thoroughly defined parameters. In this report, a summary of all results and inter-laboratory comparisons with respect to the number of identified proteins, the analysed organism, and the used techniques is presented.

  2. Investigations of DNA damage induction and repair resulting from cellular exposure to high dose-rate pulsed proton beams

    Energy Technology Data Exchange (ETDEWEB)

    Renis, M.; Malfa, G.; Tomasello, B. [Drug Sciences Department, University of Catania, Catania (Italy); Borghesi, M.; Schettino, G. [Queen' s University Belfast, Northern Ireland (United Kingdom); Favetta, M.; Romano, F.; Cirrone, G. A. P. [National Institute for Nuclear Physics (INFN-LNS), Catania (Italy); Manti, L. [Physics Science Department, University of Naples Federico II, Naples, and National Institute for Nuclear Physics (INFN), Naples (Italy)

    2013-07-26

    Studies regarding the radiobiological effects of low dose radiation, microbeam irradiation services have been developed in the world and today laser acceleration of protons and heavy ions may be used in radiation therapy. The application of different facilities is essential for studying bystander effects and relating signalling phenomena in different cells or tissues. In particular the use of ion beams results advantageous in cancer radiotherapy compared to more commonly used X-rays, since the ability of ions in delivering lethal amount of doses into the target tumour avoiding or limiting damage to the contiguous healthy tissues. At the INFN-LNS in Catania, a multidisciplinary radiobiology group is strategically structured aimed to develop radiobiological research, finalised to therapeutic applications, compatible with the use of high dose laser-driven ion beams. The characteristic non-continuous dose rates with several orders of magnitude of laser-driven ion beams makes this facility very interesting in the cellular systems' response to ultra-high dose rates with non-conventional pulse time intervals cellular studies. Our group have projected to examine the effect of high dose laser-driven ion beams on two cellular types: foetal fibroblasts (normal control cells) and DU145 (prostate cancer cells), studying the modulation of some different bio-molecular parameters, in particular cell proliferation and viability, DNA damage, redox cellular status, morphological alterations of both the cytoskeleton components and some cell organelles and the possible presence of apoptotic or necrotic cell death. Our group performed preliminary experiments with high energy (60 MeV), dose rate of 10 Gy/min, doses of 1, 2, 3 Gy and LET 1 keV/μm on human foetal fibroblasts (control cells). We observed that cell viability was not influenced by the characteristics of the beam, the irradiation conditions or the analysis time. Conversely, DNA damage was present at time 0, immediately

  3. Investigations of DNA damage induction and repair resulting from cellular exposure to high dose-rate pulsed proton beams

    Science.gov (United States)

    Renis, M.; Borghesi, M.; Favetta, M.; Malfa, G.; Manti, L.; Romano, F.; Schettino, G.; Tomasello, B.; Cirrone, G. A. P.

    2013-07-01

    Studies regarding the radiobiological effects of low dose radiation, microbeam irradiation services have been developed in the world and today laser acceleration of protons and heavy ions may be used in radiation therapy. The application of different facilities is essential for studying bystander effects and relating signalling phenomena in different cells or tissues. In particular the use of ion beams results advantageous in cancer radiotherapy compared to more commonly used X-rays, since the ability of ions in delivering lethal amount of doses into the target tumour avoiding or limiting damage to the contiguous healthy tissues. At the INFN-LNS in Catania, a multidisciplinary radiobiology group is strategically structured aimed to develop radiobiological research, finalised to therapeutic applications, compatible with the use of high dose laser-driven ion beams. The characteristic non-continuous dose rates with several orders of magnitude of laser-driven ion beams makes this facility very interesting in the cellular systems' response to ultra-high dose rates with non-conventional pulse time intervals cellular studies. Our group have projected to examine the effect of high dose laser-driven ion beams on two cellular types: foetal fibroblasts (normal control cells) and DU145 (prostate cancer cells), studying the modulation of some different bio-molecular parameters, in particular cell proliferation and viability, DNA damage, redox cellular status, morphological alterations of both the cytoskeleton components and some cell organelles and the possible presence of apoptotic or necrotic cell death. Our group performed preliminary experiments with high energy (60 MeV), dose rate of 10 Gy/min, doses of 1, 2, 3 Gy and LET 1 keV/μm on human foetal fibroblasts (control cells). We observed that cell viability was not influenced by the characteristics of the beam, the irradiation conditions or the analysis time. Conversely, DNA damage was present at time 0, immediately

  4. Investigating Gender Differences in Mathematics and Science: Results from the 2011 Trends in Mathematics and Science Survey

    Science.gov (United States)

    Reilly, David; Neumann, David L.; Andrews, Glenda

    2017-06-01

    The underrepresentation of women in science, technology, engineering, and mathematics (STEM)-related fields remains a concern for educators and the scientific community. Gender differences in mathematics and science achievement play a role, in conjunction with attitudes and self-efficacy beliefs. We report results from the 2011 Trends in Mathematics and Science Study (TIMSS), a large international assessment of eighth grade students' achievement, attitudes, and beliefs among 45 participating nations (N = 261,738). Small- to medium-sized gender differences were found for most individual nations (from d = -.60 to +.31 in mathematics achievement, and d = -.60 to +.26 for science achievement), although the direction varied and there were no global gender differences overall. Such a pattern cross-culturally is incompatible with the notion of immutable gender differences. Additionally, there were different patterns between OECD and non-OECD nations, with girls scoring higher than boys in mathematics and science achievement across non-OECD nations. An association was found between gender differences in science achievement and national levels of gender equality, providing support for the gender segregation hypothesis. Furthermore, the performance of boys was more variable than that of girls in most nations, consistent with the greater male variability hypothesis. Boys reported more favorable attitudes towards mathematics and science, and girls reported lower self-efficacy beliefs. While the gender gap in STEM achievement may be closing, there are still large sections of the world where differences remain.

  5. Acute epididymitis in ultrasound: Results of a prospective study with baseline and follow-up investigations in 134 patients

    Energy Technology Data Exchange (ETDEWEB)

    Pilatz, A., E-mail: adrian.pilatz@chiru.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany); Wagenlehner, F., E-mail: florian.wagenlehner@chiru.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany); Bschleipfer, T., E-mail: thomas.bschleipfer@chiru.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany); Schuppe, H.-C., E-mail: hans-christian.schuppe@derma.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany); Diemer, T., E-mail: thorsten.diemer@chiru.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany); Linn, T., E-mail: thomas.linn@innere.med.uni-giessen.de [Clinical Research Unit, 3rd Medical Clinic and Policlinic, Justus-Liebig University Giessen, Klinikstrasse 33, 35392 Giessen (Germany); Weidner, W., E-mail: wolfgang.weidner@chiru.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany); Altinkilic, B., E-mail: bora.altinkilic@chiru.med.uni-giessen.de [Department of Urology, Pediatric Urology and Andrology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen (Germany)

    2013-12-01

    Objectives: To perform a comprehensive follow-up analysis of ultrasonographic scrotal features and associated signs in patients with acute epididymitis. Methods: Between 2007 and 2012, 134 adults (median age 54 years) with acute epididymitis underwent scrotal ultrasonography and palpation at first presentation and after 2 weeks and 3 months. Results: At first presentation, 61 patients (45.5%) had hydrocele, 63 (47.0%) concomitant orchitis, and 8 (5.9%) epididymal abscess. Epididymitis was predominantly located in 24 cases (17.9%) in the head, 52 cases (38.8%) in the tail, and 58 cases (43.3%) in both. On the affected side, testicular volume was 16.9 ± 6.8 ml and peak systolic velocity of the testicular artery was 23.7 ± 7.5 cm/s, compared to the healthy side with 12.3 ± 4.4 ml and 9.5 ± 3.6 cm/s respectively (P < 0.001). Concomitant orchitis was associated with hydrocele, testicular enlargement and pain (P < 0.01). Orchiectomy due to secondary testicular infarction was necessary in four cases, while in all other patients ultrasound parameters normalized. Only 16/90 patients (17.8%) showed a persistent epididymal swelling after 3 months. Conclusions: Common ultrasound features include hydrocele, epididymal enlargement, hyperperfusion, and testicular involvement. Under conservative treatment, ultrasound parameters normalize without evidence of testicular atrophy even in patients with epididymal abscess or concomitant orchitis.

  6. Predictive factors for the development of diabetes in women with previous gestational diabetes mellitus

    DEFF Research Database (Denmark)

    Damm, P.; Kühl, C.; Bertelsen, Aksel

    1992-01-01

    OBJECTIVES: The purpose of this study was to determine the incidence of diabetes in women with previous dietary-treated gestational diabetes mellitus and to identify predictive factors for development of diabetes. STUDY DESIGN: Two to 11 years post partum, glucose tolerance was investigated in 241...... women with previous dietary-treated gestational diabetes mellitus and 57 women without previous gestational diabetes mellitus (control group). RESULTS: Diabetes developed in 42 (17.4%) women with previous gestational diabetes mellitus (3.7% insulin-dependent diabetes mellitus and 13.7% non......-insulin-dependent diabetes mellitus). Diabetes did not develop in any of the controls. Predictive factors for diabetes development were fasting glucose level at diagnosis (high glucose, high risk), preterm delivery, and an oral glucose tolerance test result that showed diabetes 2 months post partum. In a subgroup...

  7. Investigating the Potential Range Expansion of the Vector Mosquito Aedes Aegypti in Mexico with NASA Earth Science Remote Sensing Results

    Science.gov (United States)

    Crosson, W. L.; Estes, M. G.; Estes, S. M.; Hayden, M.; Monaghan, A. J.; Eisen, L.; Lozano-Fuentes, S.; Ochoa, C.; Tapia, B.; Welsh-Rodriquez, C. M.; a style="text-decoration: none; " href="javascript:void(0); " onClick="displayelement('author_20130001856'); toggleEditAbsImage('author_20130001856_show'); toggleEditAbsImage('author_20130001856_hide'); "> hide

    2012-01-01

    In tropical and sub ]tropical regions, the mosquito Aedes aegypti is the major vector for the virus causing dengue, a serious public health issue in these areas. Through ongoing NSF- and NASA-funded studies, field surveys of Aedes aegypti and an integrated modeling approach are being used to improve our understanding of the potential range of the mosquito to expand toward heavily populated high elevation areas such as Mexico City under various climate change and socio ]economic scenarios. This work serves three primary objectives: (1) Employ NASA remotely-sensed data to supplement the environmental monitoring and modeling component of the project. These data-- for example, surface temperature, precipitation, vegetation indices, soil moisture and elevation-- are critical for understanding the habitat necessary for mosquito survival and abundance; (2) Implement training sessions to instruct scientists and students from Mexico and the U.S. on how to use remote sensing and implement the NASA SERVIR Regional Visualization and Monitoring System; (3) Employ the SERVIR framework to optimize the dissemination of key project results in order to increase their societal relevance and benefits in developing climate adaptation strategies. Field surveys of larval, pupal and adult Aedes aegypti, as well as detailed physical and social household characteristics, were conducted in the summers of 2011and 2012 at geographic scales from the household to the community along a transect from sea level to 2400 m ASL. These data are being used in models to estimate Aedes aegypti habitat suitability. In 2011, Aedes aegypti were identified at an elevation of over 2150 m in Puebla, the highest elevation at which this species has been observed.

  8. Event Sequence Variability in Healthy Swallowing: Building on Previous Findings

    OpenAIRE

    Molfenter, Sonja M.; Leigh, Chelsea; Steele, Catriona M.

    2014-01-01

    This study builds on previous work by Kendall, Leonard and McKenzie, which investigated event sequence variability for 12 paired-events during swallowing by healthy volunteers. They identified four event pairs, which always occurred in a stereotyped order as well as a most-common occurring overall order of events during swallowing. In the current study, we investigate overall event sequencing and the same four paired-events in a sample of swallows by healthy, young (under 45 years old) volunt...

  9. SU-E-T-631: Preliminary Results for Analytical Investigation Into Effects of ArcCHECK Setup Errors

    International Nuclear Information System (INIS)

    Kar, S; Tien, C

    2015-01-01

    Purpose: As three-dimensional diode arrays increase in popularity for patient-specific quality assurance for intensity-modulated radiation therapy (IMRT), it is important to evaluate an array’s susceptibility to setup errors. The ArcCHECK phantom is set up by manually aligning its outside marks with the linear accelerator’s lasers and light-field. If done correctly, this aligns the ArcCHECK cylinder’s central axis (CAX) with the linear accelerator’s axis of rotation. However, this process is prone to error. This project has developed an analytical expression including a perturbation factor to quantify the effect of shifts. Methods: The ArcCHECK is set up by aligning its machine marks with either the sagittal room lasers or the light-field of the linear accelerator at gantry zero (IEC). ArcCHECK has sixty-six evenly-spaced SunPoint diodes aligned radially in a ring 14.4 cm from CAX. The detector response function (DRF) was measured and combined with inverse-square correction to develop an analytical expression for output. The output was calculated using shifts of 0 (perfect alignment), +/−1, +/−2 and +/−5 mm. The effect on a series of simple inputs was determined: unity, 1-D ramp, steps, and hat-function to represent uniform field, wedge, evenly-spaced modulation, and single sharp modulation, respectively. Results: Geometric expressions were developed with perturbation factor included to represent shifts. DRF was modeled using sixth-degree polynomials with correlation coefficient 0.9997. The output was calculated using simple inputs such as unity, 1-D ramp, steps, and hat-function, with perturbation factors of: 0, +/−1, +/−2 and +/−5 mm. Discrepancies have been observed, but large fluctuations have been somewhat mitigated by aliasing arising from discrete diode placement. Conclusion: An analytical expression with perturbation factors was developed to estimate the impact of setup errors on an ArcCHECK phantom. Presently, this has been applied to

  10. RESULTS FROM RECENT SCIENCE AND TECHNOLOGY INVESTIGATIONS TARGETING CHROMIUM IN THE 100D AREA HANFORD SITE WASHINGTON USA

    Energy Technology Data Exchange (ETDEWEB)

    PETERSEN SW; THOMPSON KM; TONKIN MJ

    2009-12-03

    Sodium dichromate was used in Hanford's 100D Area during the reactor operations period of 1950 to 1964 to retard corrosion in the reactor cooling systems. Some of the sodium dichromate was released to the environment by spills and/or leaks from pipelines used to deliver the chemical to water treatment plants in the area. As a result, hexavalent chromium [Cr(VI)] has migrated through the vadose zone to the groundwater and contaminated nearly 1 km{sup 2} of groundwater to above the drinking water standard of 48 {micro}g/L. Three technology tests have recently been completed in this area to characterize the source area of the plumes and evaluate alternative methods to remove Cr(VI) from groundwater. These are (1) refine the source area of the southern plume; (2) test electrocoagulation as an alternative groundwater treatment technology; and (3) test the ability to repair a permeable reactive barrier by injecting micron or nanometer-size zero-valent iron (ZVI). The projects were funded by the US Department of Energy as part of a program to interject new technologies and accelerate active cleanup. Groundwater monitoring over the past 10 years has shown that Cr(VI) concentrations in the southern plume have not significantly diminished, strongly indicating a continuing source. Eleven groundwater wells were installed in 2007 and 2008 near a suspected source area and monitored for Cr(VI) and groundwater levels. Interpretation of these data has led to refinement of the source area location to an area of less than 1 hectare (ha, 2.5 acres). Vadose zone soil samples collected during drilling did not discover significant concentrations of Cr(VI), indicating the source is localized, with a narrow wetted path from the surface to the water table. Electrocoagulation was evaluated through a pilot-scale treatability test. Over 8 million liters of groundwater were treated to Cr(VI) concentrations of {le}20 {micro}g/L. The test determined that this technology has the potential to

  11. Carbon dioxide on the satellites of Saturn: Results from the Cassini VIMS investigation and revisions to the VIMS wavelength scale

    Science.gov (United States)

    Cruikshank, D.P.; Meyer, A.W.; Brown, R.H.; Clark, R.N.; Jaumann, R.; Stephan, K.; Hibbitts, C.A.; Sandford, S.A.; Mastrapa, R.M.E.; Filacchione, G.; Ore, C.M.D.; Nicholson, P.D.; Buratti, B.J.; McCord, T.B.; Nelson, R.M.; Dalton, J.B.; Baines, K.H.; Matson, D.L.

    2010-01-01

    Several of the icy satellites of Saturn show the spectroscopic signature of the asymmetric stretching mode of C-O in carbon dioxide (CO2) at or near the nominal solid-phase laboratory wavelength of 4.2675 ??m (2343.3 cm-1), discovered with the Visible-Infrared Mapping Spectrometer (VIMS) on the Cassini spacecraft. We report here on an analysis of the variation in wavelength and width of the CO2 absorption band in the spectra of Phoebe, Iapetus, Hyperion, and Dione. Comparisons are made to laboratory spectra of pure CO2, CO2 clathrates, ternary mixtures of CO2 with other volatiles, implanted and adsorbed CO2 in non-volatile materials, and ab initio theoretical calculations of CO2 * nH2O. At the wavelength resolution of VIMS, the CO2 on Phoebe is indistinguishable from pure CO2 ice (each molecule's nearby neighbors are also CO2) or type II clathrate of CO2 in H2O. In contrast, the CO2 band on Iapetus, Hyperion, and Dione is shifted to shorter wavelengths (typically ???4.255 ??m (???2350.2 cm-1)) and broadened. These wavelengths are characteristic of complexes of CO2 with different near-neighbor molecules that are encountered in other volatile mixtures such as with H2O and CH3OH, and non-volatile host materials like silicates, some clays, and zeolites. We suggest that Phoebe's CO2 is native to the body as part of the initial inventory of condensates and now exposed on the surface, while CO2 on the other three satellites results at least in part from particle or UV irradiation of native H2O plus a source of C, implantation or accretion from external sources, or redistribution of native CO2 from the interior. The analysis presented here depends on an accurate VIMS wavelength scale. In preparation for this work, the baseline wavelength calibration for the Cassini VIMS was found to be distorted around 4.3 ??m, apparently as a consequence of telluric CO2 gas absorption in the pre-launch calibration. The effect can be reproduced by convolving a sequence of model detector

  12. Research Note Effects of previous cultivation on regeneration of ...

    African Journals Online (AJOL)

    We investigated the effects of previous cultivation on regeneration potential under miombo woodlands in a resettlement area, a spatial product of Zimbabwe's land reforms. We predicted that cultivation would affect population structure, regeneration, recruitment and potential grazing capacity of rangelands. Plant attributes ...

  13. Implant breast reconstruction after salvage mastectomy in previously irradiated patients.

    Science.gov (United States)

    Persichetti, Paolo; Cagli, Barbara; Simone, Pierfranco; Cogliandro, Annalisa; Fortunato, Lucio; Altomare, Vittorio; Trodella, Lucio

    2009-04-01

    The most common surgical approach in case of local tumor recurrence after quadrantectomy and radiotherapy is salvage mastectomy. Breast reconstruction is the subsequent phase of the treatment and the plastic surgeon has to operate on previously irradiated and manipulated tissues. The medical literature highlights that breast reconstruction with tissue expanders is not a pursuable option, considering previous radiotherapy a contraindication. The purpose of this retrospective study is to evaluate the influence of previous radiotherapy on 2-stage breast reconstruction (tissue expander/implant). Only patients with analogous timing of radiation therapy and the same demolitive and reconstructive procedures were recruited. The results of this study prove that, after salvage mastectomy in previously irradiated patients, implant reconstruction is still possible. Further comparative studies are, of course, advisable to draw any conclusion on the possibility to perform implant reconstruction in previously irradiated patients.

  14. Releasing the Results of Investigations

    Science.gov (United States)

    2010-03-01

    joke.1 Earlier in the month Mr. Arenas and teammate Javaris Crittenton – with only two years of NBA experience – “got into an argument over a card...Senior military leaders are analogous to NBA stars as both sets of professionals have risen through the ranks above their peers; they’ve reached the

  15. Previously Funded Teams | Division of Cancer Prevention

    Science.gov (United States)

    The first group of NCI-supported Tumor Glycomics Laboratories teams offered different approaches and concentrations to exploit the potential of glycomics to yield biomarkers for early cancer detection, and used various technologies to investigate complex carbohydrate biochemistry. They are listed here with links to more information about each laboratory, including publications related to their Alliance work. |

  16. Clinical effectiveness and cost-effectiveness results from the randomised, Phase IIB trial in previously untreated patients with chronic lymphocytic leukaemia to compare fludarabine, cyclophosphamide and rituximab with fludarabine, cyclophosphamide, mitoxantrone and low-dose rituximab: the Attenuated dose Rituximab with ChemoTherapy In Chronic lymphocytic leukaemia (ARCTIC) trial.

    Science.gov (United States)

    Howard, Dena R; Munir, Talha; McParland, Lucy; Rawstron, Andy C; Chalmers, Anna; Gregory, Walter M; O'Dwyer, John L; Smith, Alison; Longo, Roberta; Varghese, Abraham; Smith, Alexandra; Hillmen, Peter

    2017-05-01

    mitoxantrone. A total of 100 participants completed FCR, 79 completed FCM-miniR and 21 commenced FCM-miniR but switched to FCR following DMEC recommendations. The CR rate for participants receiving FCR was 76%, compared with 55% for FCM-miniR (adjusted odds ratio 0.37; 95% confidence interval 0.19 to 0.73). Key secondary end points also showed that FCR was superior, with more participants achieving MRD negativity (57% for FCR vs. 46% for FCM-miniR). More participants experienced a serious adverse reaction with FCM-miniR compared with FCR (50% vs. 41%). At a median of 37.3 months' follow-up, the PFS and OS rates are good compared with previous studies, with no significant difference between the treatment arms. The economic analysis indicates that because FCM-miniR is less effective than FCR, FCM-miniR is not expected to be cost-effective over a lifetime horizon, producing a mean cost-saving of -£7723, a quality-adjusted life-year loss of -0.73 and a resulting incremental net monetary loss of -£6780. FCM-miniR is less well tolerated, with poorer response rates, than FCR, partly owing to the additional toxicity associated with mitoxantrone. In view of this, FCM-miniR will not be taken forward into a larger definitive Phase III trial. The trial demonstrated that oral FCR yields extremely high response rates compared with historical series with intravenous chemotherapy. We shall compare the results of ARCTIC with those of the ADMIRE (Does the ADdition of Mitoxantrone Improve Response to FCR chemotherapy in patients with CLL?) trial, which compared FCR with FCM-R to assess the efficacy of low- versus standard-dose rituximab, allowing for the toxicity associated with mitoxantrone. Current Controlled Trials ISRCTN16544962. This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment ; Vol. 21, No. 28. See the NIHR Journals Library website for further project information.

  17. Investigation of the 27 February 2010 Mw 8.8 Chilean earthquake integrating aftershock analysis, back-projection imaging and cGPS results

    Science.gov (United States)

    Clévédé, E.; Satriano, C.; Bukchin, B.; Lancieri, M.; Fuenzalida, A.; Vilotte, J.; Lyon-Caen, H.; Vigny, C.; Socquet, A.; Aranda, C.; Campos, J. A.; Scientific Team of the Lia Montessus de Ballore (Cnrs-Insu, U. Chile)

    2010-12-01

    The Mw 8.8 earthquake in central Chile ruptured more than 400 km along the subduction bound between the Nazca and the South American plates. The aftershock distribution clearly shows that this earthquake filled a well-known seismic gap, corresponding to rupture extension of the 1835 earthquake. The triggered post-seismic activity extends farther north of the gap, partially overlapping the 1985 and the 1960 Valparaiso earthquakes. However, the analysis of continuous GPS (cGPS) recordings, and back projection imaging of teleseismic body wave energy, indicate that the rupture stopped south of Valparaiso, around -33.5 degrees of latitude. An important question is how far the rupture actually extended to the north and the potential relation between the northernmost aftershock activity and remaining asperities within the ruptured zone of the previous Valparaiso earthquakes. The extension of the rupture offshore, towards west, also deserves further investigation. The aftershock distribution and the back propagation analysis support the hypothesis that, in the northern part, the rupture may have reached the surface at the trench. In this work, we performed a CMT and depth location study for more than 10 of the immediate largest aftershocks using teleseismic surface wave analysis constrained by P-wave polarity. In parallel, a detailed analysis of aftershocks in the northern part of the rupture, between 2010-03-11 and 2010-05-13, have been performed using the data from the station of the Chilean Servicio Sismológico Nacional (SSN), and of the post-seismic network, deployed by the French CNRS-INSU, GFZ, IRIS, and Caltech. We accurately hand-picked 153 larger events, which have been located using a non-linear probabilistic code, with improved depth location. Focal mechanisms have been computed for the larger events. Those results have been integrated with the analysis of cGPS and teleseismic back projection, and the overall kinematic of the Maule earthquake is discussed as

  18. THE RESULTS OF THE INVESTIGATION OF CURRENT STATE OF INFORMATION CULTURE DEVELOPMENT PROBLEM IN THE CONTEXT OF FUTURE TRANSLATORS TRAINING FOR THE PROFESSIONAL ACTIVITY

    Directory of Open Access Journals (Sweden)

    Olha Yu. Nesterova

    2014-12-01

    Full Text Available The article deals with the results of the investigation of future translators information culture development problem as the aspect of vocational training. The investigation involved the analysis of the documents regulating the future translators education, the questionnaire of the students, academic staff, and university entrants. The article characterizes the future translators information culture development under the conditions of higher educational institutions as unsystematical and inefficient process. The author considers approaches to the integration of information culture development to the training process. As the prospective investigations the search of intensification of future translators training under the conditions of higher educational institutions was mentioned.

  19. Analysis of Product Buying Decision on Lazada E-commerce based on Previous Buyers’ Comments

    OpenAIRE

    Neil Aldrin

    2017-01-01

    The aims of the present research are: 1) to know that product buying decision possibly occurs, 2) to know how product buying decision occurs on Lazada e-commerce’s customers, 3) how previous buyers’ comments can increase product buying decision on Lazada e-commerce. This research utilizes qualitative research method. Qualitative research is a research that investigates other researches and makes assumption or discussion result so that other analysis results can be made in order to widen idea ...

  20. [Influence of previous abdominopelvic surgery on gynecological laparoscopic operation].

    Science.gov (United States)

    Jin, Haoran; Shi, Wei; Zhou, Yingfang; Wu, Beisheng; Peng, Chao

    2014-09-01

    To investigate the influence of previous abdominopelvic surgery on gynecological laparoscopic operation. A retrospective analysis of 3 283 cases of gynecological diseases by laparoscopic operation patients in Peking University First Hospital from 2007 January to 2012 December, among them, 719 (21.90%) patients with previous abdominopelvic surgery history (study Group), 2 564 (78.10%)patients have no history of abdominopelvic surgery (control group). Study group 719 patients, previous operation times: one time in 525 cases, 194 cases were multiple; previous operation: 185 cases of gynecological surgery, 305 cases of obstetric surgery, 108 cases of general surgery, and 121 complex surgery (include at least two kinds of surgery); previous operative approach: 650 cases laparotomy and 69 cases laparoscopy. Compared two groups of patients with abdominopelvic adhesion and the gynecologic laparoscopic operation situation, analyzed the influence of previous abdominopelvic surgery on abdominopelvic adhesion on and gynecological laparoscopic operation. The incidence of abdominopelvic adhesion in the patients with previous abdominopelvic surgery was 51.2% (368/719), which was significantly higher than that of 8.2% (211/2 564)in patients without previous abdominopelvic surgery (P surgery (23.1%, 166/719) was significantly higher than that in the control group (3.3% , 85/2 564;P laparotomy was 0.6% (4/719) significantly more than the control groups (0.1%, 2/2 564; P = 0.023). Compared with other groups, patients with gynecological or complex surgery or multiple operation history presented more severe abdominopelvic adhesion both in the score and degree (P laparotomy showed no statistical difference between the two groups (P > 0.05). The laparoscopic operation could be carried out successfully and safely in patients with a history of various abdominopelvic operations, but the conversion rate increases, for patients with a history of multiple operation because of pelvic adhesion

  1. Methods and results of the investigation of the thermomechanical behaviour of rock salt with regard to the final disposal of high-level radioactive wastes

    International Nuclear Information System (INIS)

    Wieczorek, K.; Klarr, K.

    1993-01-01

    This report summarizes the knowledge about thermal and mechanical behaviour of rock salt that has been accumulated by various R and D institutions in Germany from laboratory and in situ investigations. An important objective is to give a comprehensive overview of the investigation methods and instruments available and to discuss these methods and instruments with regard to their applicability and reliability for the investigation of the thermomechanical effects of high level radioactive waste emplacement in rock salt formations. The report is focused on the activities of the GSF-Institut fur Tieflagerung in the Asse mine regarding the disposal of high and intermediate level radioactive waste during the last decades. The design and the results of the most important in situ experiments are presented and discussed in detail. The results are compared to model calculations in order to evaluate the reliability of both the measurements and the calculation results. The relevance of the results for the situation in Spain is discussed in a separate chapter. As the investigations in Germany have been performed in domal salt, while the Spanish concept is based on waste disposal in bedded salt, significant differences in the thermomechanical behaviour cannot be excluded. The investigation methods, however, will be applicable. (Author)

  2. The results of the investigations on rock mechanics in HDB-9-11 boreholes and update of the rock mechanical model around the Horonobe URL construction area

    International Nuclear Information System (INIS)

    Sanada, Hiroyuki; Niunoya, Sumio; Matsui, Hiroya

    2008-09-01

    Horonobe URL (Underground Research Laboratory) Project is conducted at Horonobe-cho, Teshio-gun, Hokkaido. This research report shows the result of the rock mechanical investigations which have been carried out from 2004 to 2005 as a part of the project. The objectives of the rock mechanical investigation are as follows: To obtain the data which were necessary for construction design of URL. To confirm the distribution of rock mechanical properties in and around URL construction area. The results of the investigations are summarized as follows: 1) Variation and values of depth direction of physical and mechanical properties in the laboratory construction area corresponded approximately to the results obtained from the rock mechanical investigations of HDB-1-8. 2) The major redesign had been not had about physical and mechanical properties in the laboratory construction area being able to divide into three zones and length of its own zone in updating rock mechanical model. 3) From the results of initial stress measured by hydraulic fracturing, the results that the direction of the maximum principle stress is E-W was no different from results obtained from the investigations of HDB-1-8, but the magnitude correlation among maximum, minimum principle stress and overburden pressure measured around G.L.-927 m showed different trends compared with the results of HDB-1-8. 4) Diatomaceous mudstone was yielded under isotropic compression. Cam-clay model as constitutive law of diatomaceous mudstone should be used for tunnel excavation analysis. 5) Uniaxial compression strength of rock saturated under saline water is larger than that of saturated under freshwater. Poisson's ratio of rock saturated under saline water is smaller than that of saturated under saline water. 6) The effective confining pressure increases with the equivalent opening width and permeability decreases. 7) The value of principle stress obtained from DSCA method is larger than that obtained from hydraulic

  3. A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons

    Science.gov (United States)

    Martín Esteban, Jorge; Rodríguez Villanueva, Laura

    2017-01-01

    Despite the wide variety of pharmacological activities described for the Marrubium vulgare L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should Marrubium vulgare be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical trial methodology to establish valid and final results. PMID:28930271

  4. A Reassessment of the Marrubium Vulgare L. Herb's Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons.

    Science.gov (United States)

    Rodríguez Villanueva, Javier; Martín Esteban, Jorge; Rodríguez Villanueva, Laura

    2017-08-02

    Despite the wide variety of pharmacological activities described for the Marrubium vulgare L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should Marrubium vulgare be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical trial methodology to establish valid and final results.

  5. A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons

    Directory of Open Access Journals (Sweden)

    Javier Rodríguez Villanueva

    2017-08-01

    Full Text Available Despite the wide variety of pharmacological activities described for the Marrubium vulgare L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should Marrubium vulgare be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical trial methodology to establish valid and final results.

  6. [Family constellation in mental disorder. results and methods of statistical investigations of family size, birth order and sib position (author's transl)].

    Science.gov (United States)

    Schmidt, C W; Tölle, R

    1977-01-01

    Possibilities, difficulties and results of statistic investigations on the relation between schizophrenia, depression, neurosis and alcoholism are reported: The schizophrenic patients showed an excess of single childs and children of large sibship. In depressive patients the eldest are overrepresented. In neurotics single and eldest children are more numerous than in the general population. In alcoholic males tha last born und specially the youngest children are overrepresented. But nearly al of the relations found here have been contested by some other authors. The results are different because of the different methods. The reasons are explained in the second part of this study. The methodical differences consist in variable diagnosis, inadmissible selection, investigation without direct interviews, different statistical methods, summation of heterogenous samples and nonrepresentative controls. Methodical consequences for further investigations are discussed.

  7. Investigation of the chemical explosion of an ion exchange resin column and resulting americium contamination of personnel in the 242-Z building, August 30, 1976

    Energy Technology Data Exchange (ETDEWEB)

    1976-10-19

    As a result of an explosion in the Waste Treatment Facility, 242-Z Building, 200 West Area of the Hanford Reservation on August 30, 1976, the Manager of the Richland Operations Office (RL), Energy Research and Development Administration (ERDA), appointed an ERDA Committee to conduct a formal investigation and to prepare a report on their findings of this occurrence. The Committee was instructed to conduct the investigation in accordance with ERDAMC 0502, insofar as circumstances would permit, to cover and explain technical elements of the casual sequence(s) of the occurrence, and to describe management systems which should have or could have prevented the occurrence. This report is the result of the investigation and presents the conclusions of the review.

  8. Analyses of systems and their behaviour in extraordinary situations as based on the latest results in network sciences and extensive empirical investigations; Netzwerkanalyse fuer ein antizipatives Katastrophenmanagement

    Energy Technology Data Exchange (ETDEWEB)

    Ammoser, H. [Technische Univ. Dresden (Germany). Inst. fuer Wirtschaft und Verkehr; Kuehnert, C. [Technische Univ. Dresden (Germany). Inst. fuer Wirtschaft und Verkehr; Imperial College, London (United Kingdom); Buzna, L. [Zilina Univ. (Slovakia). Dept. of Transportation Networks

    2006-07-01

    In the context of a DFG research project, scientists of Prof. Helbing's chair at the Institute of Transport and Economics deal with the dynamics of disasters, being experienced in the modelling of complex systems and in the simulation of emergency scenarios. The analyses of systems and their behaviour in extraordinary events are based on the latest results of network sciences and on numerous empirical investigations. The results shall be used for precaution measures and innovations in disaster recovery. (orig.)

  9. (hydronsan) in previously untreated cases of pulmo

    African Journals Online (AJOL)

    B., M.D., King George V. Hospital, Durban. SUMMARY. The results of a randomized, single-blind, between-paTienI trial of various combinations of rifampicin, .... clearing after 16 weeks of trial is higher in the rifampicin- treated groups than in the ethambutol-plus-Hydronsan group. Table III shows the radiological clearing.

  10. The pathogenicity of genetic variants previously associated with left ventricular non-compaction

    DEFF Research Database (Denmark)

    Abbasi, Yeganeh; Jabbari, Javad; Jabbari, Reza

    2016-01-01

    an updated list of previously reported LVNC-associated variants with biologic description and investigate the prevalence of LVNC variants in healthy general population to find false-positive LVNC-associated variants. METHODS AND RESULTS: The Human Gene Mutation Database and PubMed were systematically...... searched to identify all previously reported LVNC-associated variants. Thereafter, the Exome Sequencing Project (ESP) and the Exome Aggregation Consortium (ExAC), that both represent the background population, was searched for all variants. Four in silico prediction tools were assessed to determine...

  11. The results of the investigations of Russian Research Center - {open_quotes}Kurchatov Institute{close_quotes} on molten salt applications to problems of nuclear energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Novikov, V.M. [Russian Research Center, Moscow (Russian Federation)

    1995-10-01

    The results of investigations on molten salt (MS) applications to problems of nuclear energy systems that have been conducted in Russian Research {open_quotes}Kurchatov Institute{close_quotes} are presented and discussed. The spectrum of these investigations is rather broad and covers the following items: physical characteristics of molten salt nuclear energy systems (MSNES); nuclear and radiation safety of MSNES; construction materials compatible with MS of different compositions; technological aspects of MS loops; in-reactor loop testing. It is shown that main findings of completed program support the conclusion that there are no physical nor technological obstacles on way of MS application to different nuclear energy systems.

  12. Control of feed intake as affected by previous treatment | Pienaar ...

    African Journals Online (AJOL)

    An experiment was conducted with eighteen rumen cannulated sheep fed on a chopped lucerne diet. Previous level of intake significantly influenced the level at which sheep initially established voluntary feed intake. This difference had disappeared after three weeks on an ad lib. intake. Perturbation analysis of the results ...

  13. Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

    DEFF Research Database (Denmark)

    Mavaddat, Nasim; Barrowdale, Daniel; Andrulis, Irene L

    2012-01-01

    BACKGROUND: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization. METHODS: We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze the path......BACKGROUND: Previously, small studies have found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization. METHODS: We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze...... the pathology of invasive breast, ovarian, and contralateral breast cancers. RESULTS: There was strong evidence that the proportion of estrogen receptor (ER)-negative breast tumors decreased with age at diagnosis among BRCA1 (P-trend = 1.2 × 10(-5)), but increased with age at diagnosis among BRCA2, carriers (P......-trend = 6.8 × 10(-6)). The proportion of triple-negative tumors decreased with age at diagnosis in BRCA1 carriers but increased with age at diagnosis of BRCA2 carriers. In both BRCA1 and BRCA2 carriers, ER-negative tumors were of higher histologic grade than ER-positive tumors (grade 3 vs. grade 1; P = 1...

  14. Rates of induced abortion in Denmark according to age, previous births and previous abortions

    Directory of Open Access Journals (Sweden)

    Marie-Louise H. Hansen

    2009-11-01

    Full Text Available Background: Whereas the effects of various socio-demographic determinants on a woman's risk of having an abortion are relatively well-documented, less attention has been given to the effect of previous abortions and births. Objective: To study the effect of previous abortions and births on Danish women's risk of an abortion, in addition to a number of demographic and personal characteristics. Data and methods: From the Fertility of Women and Couples Dataset we obtained data on the number of live births and induced abortions by year (1981-2001, age (16-39, county of residence and marital status. Logistic regression analysis was used to estimate the influence of the explanatory variables on the probability of having an abortion in a relevant year. Main findings and conclusion: A woman's risk of having an abortion increases with the number of previous births and previous abortions. Some interactions were was found in the way a woman's risk of abortion varies with calendar year, age and parity. The risk of an abortion for women with no children decreases while the risk of an abortion for women with children increases over time. Furthermore, the risk of an abortion decreases with age, but relatively more so for women with children compared to childless women. Trends for teenagers are discussed in a separate section.

  15. Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs

    Directory of Open Access Journals (Sweden)

    Lannfelt Lars

    2009-12-01

    Full Text Available Abstract Background Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes. Methods In the present study, we have combined a selection of affected relative pairs (ARPs from the UK and the USA included in a previous linkage study by Myers et al. (Am J Med Genet, 2002, with ARPs from Sweden and Washington University. In this total sample collection of 397 ARPs, we have analyzed linkage to chromosomes 1, 9, 10, 12, 19 and 21, implicated in the previous scan. Results The analysis revealed that linkage to chromosome 19q13 close to the APOE locus increased considerably as compared to the earlier scan. However, linkage to chromosome 10q21, which provided the strongest linkage in the previous scan could not be detected. Conclusion The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.

  16. Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients.

    Science.gov (United States)

    Reinders, Mattheus K; van Roon, Eric N; Houtman, Pieternella M; Brouwers, Jacobus R B J; Jansen, Tim L Th A

    2007-09-01

    In 2003, the uricosuric drug benzbromarone was withdrawn from the market. The first alternative drug of choice was the xanthine oxidase inhibitor allopurinol. The purpose was to (1) investigate the efficacy of allopurinol (standard dosage) compared with previous treatment with benzbromarone; and (2) investigate the combination therapy allopurinol-probenecid as an effective alternative treatment compared with previous benzbromarone treatment. A prospective, open study was carried out in a cohort of 51 gout patients who discontinued benzbromarone therapy because of market withdrawal. Patients were given 200-300 mg allopurinol (stage 1). When allopurinol failed to attain the target serum urate (sUr) levels probenecid 1,000 mg/day was added (stage 2). Treatment with benzbromarone monotherapy (range: 100-200 mg/day; mean 138 mg/day) resulted in 92% of patients reaching target levels sUr probenecid combination therapy, which resulted in 86% of patients attaining target sUr levels (after failure on allopurinol monotherapy), which was comparable to previous treatment with benzbromarone (p = 0.81). Decrease in sUr levels was 53[9]% (CI 95%: 48-58%), which was a non-significant difference compared to previous treatment with benzbromarone (p = 0.23). Benzbromarone is a very effective antihyperuricemic drug with 91% success in attainment of target sUr levels probenecid proves to be an effective treatment strategy for attaining sUr target levels (86% success).

  17. Investigation and analysis of a reported incident resulting in an actual airline hijacking due to a fanatical and engrossed VR state.

    Science.gov (United States)

    Ichimura, A; Nakajima, I; Juzoji, H

    2001-06-01

    We begin this report by defining Chronic Alternate-World Disorder (CAWD) as a symptomatic behavior in which a person becomes fanatically engrossed in a virtual-reality (VR) world to the extent that he or she can no longer distinguish between the actual world and virtual reality. We then report on our investigation and provide an analysis and discussion of what we believe to be a case of CAWD. The case in question involves a perpetrator who hijacked a jumbo jetliner in order to fly the airplane on his own, after developing CAWD from the use of light-simulator software. Psychiatrists and physicians specializing in VR-related disorders have analyzed the case's psychological, social, and technical background based on previously disclosed information. We believe symptomatic cases of CAWD will increase as VR spreads throughout our society. In view of this, our objective is to propose precautionary and preventive measures for providers of VR systems for patients with schizophrenia or personality disorders, from psychiatric and sociological perspectives.

  18. Clinical profile and therapeutic management of patients with atrial fibrillation in Greece: results from the Registry of Atrial Fibrillation to Investigate New Guidelines (RAFTING).

    Science.gov (United States)

    Farmakis, Dimitrios; Pipilis, Athanasios; Antoniou, Anna; Kaliambakos, Sotirios; Goudevenos, John; Anastasiou-Nana, Maria; Pyrgakis, Vlassios; Parcharidis, Georgios; Lekakis, John

    2013-01-01

    Atrial fibrillation (AF) is the most common arrhythmia with significant morbidity, including a 5-fold increase in stroke risk. The management of AF, including antithrombotic therapy (AT), varies considerably among countries. Representative data concerning AF features and management in Greece are generally lacking. The Registry of Atrial Fibrillation To Investigate New Guidelines (RAFTING) is a country-wide prospective observational study of AF in Greece that enrolled consecutive patients with a diagnosis of AF in emergency departments of 31 hospitals of different types according to the population's geographical distribution. RAFTING enrolled 1127 patients, 51% females, aged 71 ± 12 years. Paroxysmal AF was present in 54% of patients and newly diagnosed AF in 28%; 68% of patients with a previous AF history had undergone a median of 4 cardioversions. A high rate of comorbidities was present, including arterial hypertension in 75% and heart failure in 40%. The median CHADS2 and CHA2DS2VASc scores were 2 and 3, respectively; AT had been prescribed in 87% of non-newly diagnosed patients, with warfarin being prescribed in 56% of them. Among all patients on warfarin, INR values were within therapeutic range in 34% of cases during inhospital measurement. Hospital admission occurred in 82% of cases, with in-hospital mortality 0.8%. RAFTING provides updated insights into the current features and management of AF in Greece. The majority of patients have a sufficiently high risk to warrant oral anticoagulation and further attempts to comply with the existing guidelines are warranted.

  19. Congruency sequence effects are driven by previous-trial congruency, not previous-trial response conflict

    OpenAIRE

    Weissman, Daniel H.; Carp, Joshua

    2013-01-01

    Congruency effects in distracter interference tasks are often smaller after incongruent trials than after congruent trials. However, the sources of such congruency sequence effects (CSEs) are controversial. The conflict monitoring model of cognitive control links CSEs to the detection and resolution of response conflict. In contrast, competing theories attribute CSEs to attentional or affective processes that vary with previous-trial congruency (incongruent vs. congruent). The present study s...

  20. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev, and results from the year of construction

    International Nuclear Information System (INIS)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2003-01-01

    The present report presents the base-line investigations of birds conducted during August 1999-April 2001 in relation to construction of an offshore wind farm at Horns Rev, 14 km west-south-west of Blaevandshuk, in the Danish North Sea. The report also presents data collected during the period September 2001-April 2002, when construction of the wind farm was in progress. The wind farm will consist of 80 wind turbines, each of 2 MW, and cover an area of c. 20 km 2 . The eastern part of the North Sea constitutes major staging and wintering grounds for huge numbers of water- and seabirds. The area is also known to be an important site for migrating birds, which especially in autumn pass in large numbers. As Denmark has obligations to protect and maintain the bird populations it was laid down in the approval for erection of the wind farm that the impact on birds should be investigated. According to the 1% criteria defined in the Ramsar Convention, the eastern part of the North Sea including the wind farm area is of international importance to divers, Common Tern, and Sandwich Tern. A number of other species, e.g. Common Eider, Common Scoter, Guillemot and Razorbill, are present in the area in significant numbers as well, though these numbers do not make up 1% of the populations. Detailed distributions of birds in the area around and at Horns Rev were virtually unknown until initiation of this project. Previous bird counts in this area have been carried out almost exclusively from the coast and detailed knowledge exists concerning the numbers of roosting at and migrating birds from the westernmost point of Jutland, Blaevandshuk. To describe the numbers and distributions of birds staging and wintering in the Horns Rev area, bird investigations were initiated in 1999 by using standardised transect counts from aircraft. Up to April 2002, 18 aerial counts have been carried out over an area of c. 1,700 km 2 centred on the Horns Rev project area. (au)

  1. Base-line investigations of birds in relation to an offshore wind farm at Horns Rev, and results from the year of construction

    Energy Technology Data Exchange (ETDEWEB)

    Kjaer Christensen, T.; Clausager, I.; Krag Petersen, I.

    2003-04-15

    The present report presents the base-line investigations of birds conducted during August 1999-April 2001 in relation to construction of an offshore wind farm at Horns Rev, 14 km west-south-west of Blaevandshuk, in the Danish North Sea. The report also presents data collected during the period September 2001-April 2002, when construction of the wind farm was in progress. The wind farm will consist of 80 wind turbines, each of 2 MW, and cover an area of c. 20 km{sup 2}. The eastern part of the North Sea constitutes major staging and wintering grounds for huge numbers of water- and seabirds. The area is also known to be an important site for migrating birds, which especially in autumn pass in large numbers. As Denmark has obligations to protect and maintain the bird populations it was laid down in the approval for erection of the wind farm that the impact on birds should be investigated. According to the 1% criteria defined in the Ramsar Convention, the eastern part of the North Sea including the wind farm area is of international importance to divers, Common Tern, and Sandwich Tern. A number of other species, e.g. Common Eider, Common Scoter, Guillemot and Razorbill, are present in the area in significant numbers as well, though these numbers do not make up 1% of the populations. Detailed distributions of birds in the area around and at Horns Rev were virtually unknown until initiation of this project. Previous bird counts in this area have been carried out almost exclusively from the coast and detailed knowledge exists concerning the numbers of roosting at and migrating birds from the westernmost point of Jutland, Blaevandshuk. To describe the numbers and distributions of birds staging and wintering in the Horns Rev area, bird investigations were initiated in 1999 by using standardised transect counts from aircraft. Up to April 2002, 18 aerial counts have been carried out over an area of c. 1,700 km{sup 2} centred on the Horns Rev project area. (au)

  2. Recent results of the parameters A and R measurements in the resonance region of the πN-elastic scattering and subsequent investigations.

    Science.gov (United States)

    Sumachev, V. V.; Beloglazov, Yu. A.; Filimonov, E. A.; Kovalev, A. I.; Kozlenko, N. G.; Kruglov, S. P.; Kulbardis, A. A.; Lopatin, I. V.; Novinsky, D. V.; Shchedrov, V. A.; Trautman, V. Yu.; Alekseev, I. G.; Budkovsky, P. E.; Kanavets, V. P.; Koroleva, L. I.; Morozov, B. V.; Nesterov, V. M.; Ryltsov, V. V.; Sulimov, A. D.; Svirida, D. N.; Bazhanov, N. A.; Bunyatova, E. I.

    2008-10-01

    The existing models of baryons usually predict considerably more resonance (three or more in number) than it was found by investigation of elastic pion-nucleon scattering. This disagreement invites further investigation of the pion-nucleon interaction and among other things the measurement of spin rotation parameters A and R in the elastic pion-nucleon scattering. Recent experiments of the PNPI and PNPI-ITEP collaborations resolved a part of twofold ambiguities of the existing partial wave analyses (PWA). These results were used in the last PWA of the George Washington University group SP06. The proposal for the additional spin rotation parameters A and R measurement in the resonance region is motivated. Such additional measurements are necessary to resolve remaining twofold ambiguities of the existing PWAs.

  3. The Investigation of Acoustic Properties of Carbon Fiber-Polyester Composites and Comparing the Results with Poplar, Walnut and Beech Wood Specimens

    Directory of Open Access Journals (Sweden)

    Amir soheil Pirayeshfar

    2011-12-01

    Full Text Available In this paper, regarding the high capability of polymeric composites as a substitute of the wood in musical instruments, the acoustic properties of carbon fiber-polyester composites, such as elastic modulus, acoustic coefficient, acoustic coefficient efficiency etc, were investigated using free longitudinal and flexural vibration non-destructive tests and forced vibration non-destructive test. For better understanding, three wooden samples of poplar, walnut and beech trees (frequently used in the manufacturing of musical instruments were chosen and analyzed. Comparing the results showed that the resultant composites had essential acoustic and vibrational properties higher than those of wood samples. Ultrasonic velocity and elastic modulus in longitudinal direction of carbon composites were approximately 11300 m/s and 130GPa, respectively. Besides, the damping results of carbon composites are magnificent and far better than those of the wood specimens.

  4. Fulminant Pneumococcal Pericarditis in a Previously Healthy Patient.

    Science.gov (United States)

    Trpkov, Cvetan; Nath, Ermin; Moon, Michael; Windram, Jonathan; Graham, Michelle M

    2017-04-01

    Purulent pericarditis is a rare acutely life-threatening condition. Initial symptoms, signs, and investigations can be nonspecific. Echocardiography is invaluable for establishing the diagnosis and initial management. We present a case of a previously healthy patient with purulent pericarditis caused by Streptococcus pneumoniae in the absence of a primary focus of infection. The patient deteriorated rapidly with cardiac tamponade and septic shock and was managed successfully by a combined medical and surgical approach. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  5. On an outline of investigation results of earthquake damage estimation for Akita prefecture; Akitaken jishin higai sotei chosa kekka no gaiyo ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Nogoshi, M. [Akita University, Akita (Japan). College of Education

    1997-05-27

    This paper reports an outline of investigation results of earthquake damage estimation carried out in Akita Prefecture. The basic policy for this investigation consists of the following: (1) an indication on existence of a blank area in the Akita off-coast earthquake shall be viewed so importantly that a fault model is set to estimate damages; (2) because most of the earthquakes in history of Akita Prefecture are inland earthquakes with magnitude of about M=7, four earthquakes in the past shall be adopted as the set model; and (3) the central Sea of Japan earthquake in 1983 was an earthquake occurred in the Sea of Japan side and caused a great deal of damages to Akita Prefecture, and its epicenter model and damages were investigated in detail, hence these data shall be utilized in verifying the procedure and method for estimating damages studied in the present investigation. This paper reports finally estimated human damages. With an assumed earthquake as strong as the Tencho earthquake in the year of 830, more than 1000 deaths will occur in the city of Akita; with an earthquake in the scale of the Noshiro earthquake in 1694, more than 50 deaths will be counted in the city of Noshiro; one as strong as the Rikuu earthquake in 1896 will cause about 300 deaths in the cities of Yokote and Omagari, respectively; one with the scale of the 1914 Goushu earthquake will result in about 300 people to be killed in the city of Omagari and about 200 people in the city of Yuzawa; and an earthquake estimated to occur in the blank area off the Akita coast will force 33% of the residents of the Kisakata town to be evacuated from their homes. 1 fig.

  6. Investigation of error estimation method of observational data and comparison method between numerical and observational results toward V and V of seismic simulation

    International Nuclear Information System (INIS)

    Suzuki, Yoshio; Kawakami, Yoshiaki; Nakajima, Norihiro

    2017-01-01

    The method to estimate errors included in observational data and the method to compare numerical results with observational results are investigated toward the verification and validation (V and V) of a seismic simulation. For the method to estimate errors, 144 literatures for the past 5 years (from the year 2010 to 2014) in the structure engineering field and earthquake engineering field where the description about acceleration data is frequent are surveyed. As a result, it is found that some processes to remove components regarded as errors from observational data are used in about 30% of those literatures. Errors are caused by the resolution, the linearity, the temperature coefficient for sensitivity, the temperature coefficient for zero shift, the transverse sensitivity, the seismometer property, the aliasing, and so on. Those processes can be exploited to estimate errors individually. For the method to compare numerical results with observational results, public materials of ASME V and V Symposium 2012-2015, their references, and above 144 literatures are surveyed. As a result, it is found that six methods have been mainly proposed in existing researches. Evaluating those methods using nine items, advantages and disadvantages for those methods are arranged. The method is not well established so that it is necessary to employ those methods by compensating disadvantages and/or to search for a solution to a novel method. (author)

  7. Energy savings by reduced mixing in aeration tanks: Results from a full scale investigation and long term implementation at Avedoere wastewater treatment plant

    DEFF Research Database (Denmark)

    Sharma, Anitha Kumari; Guildal, T.; Thomsen, H.R.

    2011-01-01

    The aim of this project was to investigate the potential of reducing number of mixers in the biological treatment process and thereby achieve energy and economical savings and contribute to cleaner environment. The project was carried out at Avedoere wastewater treatment plant and a full scale in...... has been operating with 50% of its designed number of mixers since September 2007 and long term results also confirm that reduced mixing did not have any negative effect on treatment efficiency. The estimated yearly electricity saving is 0.75 GWh/year. © IWA Publishing 2011....

  8. Previous climatic alterations are caused by the sun

    International Nuclear Information System (INIS)

    Groenaas, Sigbjoern

    2003-01-01

    The article surveys the scientific results of previous research into the contribution of the sun to climatic alterations. The author concludes that there is evidence of eight cold periods after the last ice age and that the alterations largely were due to climate effects from the sun. However, these effects are only causing a fraction of the registered global warming. It is assumed that the human activities are contributing to the rest of the greenhouse effect

  9. The effect of previous traumatic injury on homicide risk.

    Science.gov (United States)

    Griffin, Russell L; Davis, Gregory G; Levitan, Emily B; MacLennan, Paul A; Redden, David T; McGwin, Gerald

    2014-07-01

    Research has reported that a strong risk factor for traumatic injury is having a previous injury (i.e., recidivism). To date, the only study examining the relationship between recidivism and homicide reported strong associations, but was limited by possible selection bias. The current matched case-control study utilized coroner's data from 2004 to 2008. Subjects were linked to trauma registry data to determine whether the person had a previous traumatic injury. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between homicide and recidivism. Homicide risk was increased for those having a previous traumatic injury (OR 1.81, 95% CI 1.09-2.99) or a previous intentional injury (OR 2.53, 95% CI 1.24-5.17). These results suggest an association between homicide and injury recidivism, and that trauma centers may be an effective setting for screening individuals for secondary prevention efforts of homicide through violence prevention programs. © 2014 American Academy of Forensic Sciences.

  10. Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq)

    Science.gov (United States)

    Ouma, Wilberforce Zachary; Mejia-Guerra, Maria Katherine; Yilmaz, Alper; Pareja-Tobes, Pablo; Li, Wei; Doseff, Andrea I.; Grotewold, Erich

    2015-01-01

    Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide genome-wide transcription factor binding sites (TFBSs). ChIP-Seq furnishes millions of short reads that, after alignment, describe the genome-wide binding sites of a particular TF. However, in all organisms investigated an average of 40% of reads fail to align to the corresponding genome, with some datasets having as much as 80% of reads failing to align. We describe here the provenance of previously unaligned reads in ChIP-Seq experiments from animals and plants. We show that a substantial portion corresponds to sequences of bacterial and metazoan origin, irrespective of the ChIP-Seq chromatin source. Unforeseen was the finding that 30%–40% of unaligned reads were actually alignable. To validate these observations, we investigated the characteristics of the previously unaligned reads corresponding to TAL1, a human TF involved in lineage specification of hemopoietic cells. We show that, while unmapped ChIP-Seq read datasets contain foreign DNA sequences, additional TFBSs can be identified from the previously unaligned ChIP-Seq reads. Our results indicate that the re-evaluation of previously unaligned reads from ChIP-Seq experiments will significantly contribute to TF target identification and determination of emerging properties of GRNs. PMID:25727450

  11. Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).

    Science.gov (United States)

    Aleksandrova, Krasimira; Jenab, Mazda; Bueno-de-Mesquita, H Bas; Fedirko, Veronika; Kaaks, Rudolf; Lukanova, Annekatrin; van Duijnhoven, Fränzel J B; Jansen, Eugene; Rinaldi, Sabina; Romieu, Isabelle; Ferrari, Pietro; Murphy, Neil; Gunter, Marc J; Riboli, Elio; Westhpal, Sabine; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Boutron-Ruault, Marie-Christine; Dossus, Laure; Racine, Antoine; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Agnoli, Claudia; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Vineis, Paolo; Peeters, Petra H; Duell, Eric J; Molina-Montes, Esther; Quirós, J Ramón; Dorronsoro, Miren; Chirlaque, Maria-Dolores; Barricarte, Aurelio; Ljuslinder, Ingrid; Palmqvist, Richard; Travis, Ruth C; Khaw, Kay-Tee; Wareham, Nicholas; Pischon, Tobias; Boeing, Heiner

    2014-04-01

    A number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). During median follow-up time of 7.0 (3.7-9.4) years, 1,260 incident CRC cases occurred and were matched to 1,260 controls using risk-set sampling. Pre-diagnostic measurements of C-peptide, glycated hemoglobin, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), reactive oxygen metabolites (ROM), insulin-like growth factor 1, adiponectin, leptin and soluble leptin receptor (sOB-R) were used to derive biomarker patterns from principal component analysis (PCA). The relation with CRC incidence was assessed using conditional logistic regression models. We identified four biomarker patterns 'HDL-C/Adiponectin fractions', 'ROM/CRP', 'TG/C-peptide' and 'leptin/sOB-R' to explain 60 % of the overall biomarker variance. In multivariable-adjusted logistic regression, the 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' patterns were associated with CRC risk [for the highest quartile vs the lowest, incidence rate ratio (IRR) = 0.69, 95 % CI 0.51-0.93, P-trend = 0.01; IRR = 1.70, 95 % CI 1.30-2.23, P-trend = 0.002; and IRR = 0.79, 95 % CI 0.58-1.07; P-trend = 0.05, respectively]. In contrast, the 'TG/C-peptide' pattern was not associated with CRC risk (IRR = 0.75, 95 % CI 0.56-1.00, P-trend = 0.24). After cases within the first 2 follow-up years were excluded, the 'ROM/CRP' pattern was no longer associated with CRC risk, suggesting potential influence of preclinical disease on these associations. By application of PCA, the study identified 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' as

  12. Using a bayesian latent class model to evaluate the utility of investigating persons with negative polymerase chain reaction results for pertussis.

    Science.gov (United States)

    Tarr, Gillian A M; Eickhoff, Jens C; Koepke, Ruth; Hopfensperger, Daniel J; Davis, Jeffrey P; Conway, James H

    2013-07-15

    Pertussis remains difficult to control. Imperfect sensitivity of diagnostic tests and lack of specific guidance regarding interpretation of negative test results among patients with compatible symptoms may contribute to its spread. In this study, we examined whether additional pertussis cases could be identified if persons with negative pertussis test results were routinely investigated. We conducted interviews among 250 subjects aged ≤18 years with pertussis polymerase chain reaction (PCR) results reported from 2 reference laboratories in Wisconsin during July-September 2010 to determine whether their illnesses met the Centers for Disease Control and Prevention's clinical case definition (CCD) for pertussis. PCR validity measures were calculated using the CCD as the standard for pertussis disease. Two Bayesian latent class models were used to adjust the validity measures for pertussis detectable by 1) culture alone and 2) culture and/or more sensitive measures such as serology. Among 190 PCR-negative subjects, 54 (28%) had illnesses meeting the CCD. In adjusted analyses, PCR sensitivity and the negative predictive value were 1) 94% and 99% and 2) 43% and 87% in the 2 types of models, respectively. The models suggested that public health follow-up of reported pertussis patients with PCR-negative results leads to the detection of more true pertussis cases than follow-up of PCR-positive persons alone. The results also suggest a need for a more specific pertussis CCD.

  13. Contamination during production of heater-cooler units by Mycobacterium chimaera potential cause for invasive cardiovascular infections: results of an outbreak investigation in Germany, April 2015 to February 2016.

    Science.gov (United States)

    Haller, Sebastian; Höller, Christiane; Jacobshagen, Anja; Hamouda, Osamah; Abu Sin, Muna; Monnet, Dominique L; Plachouras, Diamantis; Eckmanns, Tim

    2016-04-28

    Invasive infections with Mycobacterium chimaera were reported in patients with previous open chest surgery and exposure to contaminated heater-cooler units (HCUs). We present results of the surveillance of clinical cases and of contaminated HCUs as well as environmental investigations in Germany up until February 2016. Clinical infections occurred in five male German cases over 50 years of age (range 53-80). Cases had been exposed to HCUs from one single manufacturer during open chest surgery up to five years prior to onset of symptoms. During environmental investigations, M. chimaera was detected in samples from used HCUs from three different countries and samples from new HCUs as well as in the environment at the manufacturing site of one manufacturer in Germany. Our investigation suggests that at least some of the M. chimaera infections may have been caused by contamination of HCUs at manufacturing site. We recommend that until sustainable measures for safe use of HCUs in operation theatres are implemented, users continue to adhere to instructions for use of HCUs and Field Safety Notices issued by the manufacturer, implement local monitoring for bacterial contamination and continuously check the websites of national and European authorities for current recommendations for the safe operation of HCUs.

  14. NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 35: The US government technical report and aerospace knowledge diffusion: Results of an on-going investigation

    Science.gov (United States)

    Pinelli, Thomas E.; Khan, A. Rahman; Barclay, Rebecca O.; Kennedy, John M.

    1993-01-01

    The U.S. government technical report is a primary means by which the results of federally funded research and development (R&D) are transferred to the U.S. aerospace industry. However, little is known about this information product in terms of its actual use, importance, and value in the transfer of federally funded (U.S.) R&D. To help establish a body of knowledge, the U.S. government technical report is being investigated as part of the NASA/DOD Aerospace Knowledge Diffusion Research Project. In this paper, we summarize the literature on technical reports and provide a model that depicts the transfer of federally funded aerospace R&D via the U.S. government technical report. We present results from two surveys (one of five studies) of our investigation of aerospace knowledge diffusion vis-a-vis the U.S. government technical report and close with a brief overview of on-going research into the use of the U.S. government technical report as a rhetorical device for transferring federally funded aerospace R&D.

  15. Factors that influence the turnover intention of Chinese village doctors based on the investigation results of Xiangyang City in Hubei Province.

    Science.gov (United States)

    Fang, Pengqian; Liu, Xiangli; Huang, Lingxiao; Zhang, Xiaoyan; Fang, Zi

    2014-11-04

    This study analyzes the factors that influence the turnover intention of village doctors by investigating village clinic workers in rural areas, particularly in Xiangyang City, Hubei Province. A total of 1184 village clinics were sampled randomly in Xiangyang City. The research assistants distributed 1930 questionnaires to village doctors. This study had a response rate of 97.88%. A total of 1889 village doctors completed the questionnaires. The results of the investigation conducted in Xiangyang City indicated that 63.2% of the village doctors did not plan to leave the organization where they were currently employed. However, more than one-third (36.8%) of the village doctors considered leaving their posts voluntarily. Some job satisfaction indexes affect their intention to resign. The results showed that income satisfaction and the way organization policies are put into practice, in addition, my pay and the amount of work I do, the chances for advancement on this job and the work conditions are significant factors that contribute to the turnover intention of village doctors. This study may interest heath care management administrator and highlight the influence of job satisfaction on turnover intention of village doctors. Our findings outline some issues that contribute to these problems and suggest an approach for health care policy maker to implement a broader national process and organizational strategies to improve the job satisfaction and stability of the village doctors.

  16. Tubal anastomosis after previous sterilization: a systematic review.

    Science.gov (United States)

    van Seeters, Jacoba A H; Chua, Su Jen; Mol, Ben W J; Koks, Carolien A M

    2017-05-01

    Female sterilization is one of the most common contraceptive methods. A small number of women, however, opt for reversal of sterilization procedures after they experience regret. Procedures can be performed by laparotomy or laparoscopy, with or without robotic assistance. Another commonly utilized alternative is IVF. The choice between surgery and IVF is often influenced by reimbursement politics for that particular geographic location. We evaluated the fertility outcomes of different surgical methods available for the reversal of female sterilization, compared these to IVF and assessed the prognostic factors for success. Two search strategies were employed. Firstly, we searched for randomized and non-randomized clinical studies presenting fertility outcomes of sterilization reversal up to July 2016. Data on the following outcomes were collected: pregnancy rate, ectopic pregnancy rate, cost of the procedure and operative time. Eligible study designs included prospective or retrospective studies, randomized controlled trials, cohort studies, case-control studies and case series. No age restriction was applied. Exclusion criteria were patients suffering from tubal infertility from any other reason (e.g. infection, endometriosis and adhesions from previous surgery) and studies including sterilization reversal procedures were then evaluated: female age, BMI and duration and method of sterilization. Secondly, we searched for randomized and non-randomized clinical studies that compared reversal of sterilization to IVF and evaluated them for pregnancy outcomes and cost effectiveness. We included 37 studies that investigated a total of 10 689 women. No randomized controlled trials were found. Most studies were retrospective cohort studies of a moderate quality. The pooled pregnancy rate after sterilization reversal was 42-69%, with heterogeneity seen from the different methods utilized. The reported ectopic pregnancy rate was 4-8%. The only prognostic factor affecting the

  17. Kidnapping Detection and Recognition in Previous Unknown Environment

    Directory of Open Access Journals (Sweden)

    Yang Tian

    2017-01-01

    Full Text Available An unaware event referred to as kidnapping makes the estimation result of localization incorrect. In a previous unknown environment, incorrect localization result causes incorrect mapping result in Simultaneous Localization and Mapping (SLAM by kidnapping. In this situation, the explored area and unexplored area are divided to make the kidnapping recovery difficult. To provide sufficient information on kidnapping, a framework to judge whether kidnapping has occurred and to identify the type of kidnapping with filter-based SLAM is proposed. The framework is called double kidnapping detection and recognition (DKDR by performing two checks before and after the “update” process with different metrics in real time. To explain one of the principles of DKDR, we describe a property of filter-based SLAM that corrects the mapping result of the environment using the current observations after the “update” process. Two classical filter-based SLAM algorithms, Extend Kalman Filter (EKF SLAM and Particle Filter (PF SLAM, are modified to show that DKDR can be simply and widely applied in existing filter-based SLAM algorithms. Furthermore, a technique to determine the adapted thresholds of metrics in real time without previous data is presented. Both simulated and experimental results demonstrate the validity and accuracy of the proposed method.

  18. Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic leukemia, other lymphomas and multiple myeloma-results of the European Prospective Investigation into Cancer and Nutrition

    NARCIS (Netherlands)

    Nieters, Alexandra; Luczynska, Anna; Becker, Susen; Becker, Nikolaus; Vermeulen, Roel; Overvad, Kim; Aleksandrova, Krasimira; Boeing, Heiner; Lagiou, Pagona; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Krogh, Vittorio; Masala, Giovanna; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Bueno-de-Mesquita, Bas; Jeurnink, Suzanne M.; Weiderpass, Elisabete; Ardanaz, Eva; Chirlaque, Maria-Dolores; Sanchez, Maraia-Jose; Sanchez, Soledad; Borgquist, Signe; Butt, Salma; Melin, Beatrice; Spaeth, Florentin; Rinaldi, Sabina; Brennan, Paul; Kelly, Rachel S.; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolf

    2014-01-01

    Previous epidemiological studies suggest an inverse association between allergies, marked by elevated immunoglobulin (Ig) E levels, and non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent and prospective data are sparse. We examined the association between prediagnostic total

  19. Pain related to mandibular block injections and its relationship with anxiety and previous experiences with dental anesthetics

    NARCIS (Netherlands)

    van Wijk, A.; Lindeboom, J.A.; de Jongh, A.; Tuk, J.G.; Hoogstraten, J.

    2012-01-01

    Objective. Anesthetic injections should reassure patients with the prospect of painless treatment, but for some patients it is the main source of their fear. We investigated pain resulting from mandibular block injections in relation to anxiety and previous experience with receiving injections.

  20. Annual report on the Background Soil Characterization Project on the Oak Ridge Reservation, Oak Ridge, Tennessee: Results of Phase 1 investigation

    International Nuclear Information System (INIS)

    Watkins, D.R.; Goddard, P.L.; Hatmaker, T.L.; Hook, L.A.; Jackson, B.L.; Kimbrough, C.W.; Lee, S.Y.; Lietzke, D.A.; McGin, C.W.; Nourse, B.D.; Schmoyer, R.L.; Shaw, R.A.; Stinnette, S.E.; Switek, J.; Wright, J.C.; Ammons, J.T.; Branson, J.L.; Burgoa, B.B.

    1993-05-01

    Many constituents of potential concern for human health occur naturally at low concentrations in undisturbed soils. The Background soil Characterization Project (BSCP) was undertaken to provide background concentration data on potential contaminants in natural soils on the Oak Ridge Reservation (ORR). The objectives of the BSCP are to provide baseline data for contaminated site assessment and estimates of potential human health risk associated with background concentrations of hazardous and other constituents in native soils. This report presents, evaluates, and documents data and results obtained in Phase I of the project. It is intended to be a stand-alone document for application and use in structuring and conducting remedial investigation and remedial action projects in the Environmental Restoration (ER) Program

  1. Annual report on the Background Soil Characterization Project on the Oak Ridge Reservation, Oak Ridge, Tennessee: Results of Phase 1 investigation

    Energy Technology Data Exchange (ETDEWEB)

    Watkins, D.R.; Goddard, P.L.; Hatmaker, T.L.; Hook, L.A.; Jackson, B.L.; Kimbrough, C.W.; Lee, S.Y.; Lietzke, D.A.; McGin, C.W.; Nourse, B.D.; Schmoyer, R.L.; Shaw, R.A.; Stinnette, S.E.; Switek, J.; Wright, J.C. [Oak Ridge National Lab., TN (United States); Ammons, J.T.; Branson, J.L.; Burgoa, B.B. [Tennessee Univ., Knoxville, TN (United States). Dept. of Plant and Soil Science; Lietzke, D.A. [Lietzke (David A.), Rutledge, TN (United States)

    1993-05-01

    Many constituents of potential concern for human health occur naturally at low concentrations in undisturbed soils. The Background soil Characterization Project (BSCP) was undertaken to provide background concentration data on potential contaminants in natural soils on the Oak Ridge Reservation (ORR). The objectives of the BSCP are to provide baseline data for contaminated site assessment and estimates of potential human health risk associated with background concentrations of hazardous and other constituents in native soils. This report presents, evaluates, and documents data and results obtained in Phase I of the project. It is intended to be a stand-alone document for application and use in structuring and conducting remedial investigation and remedial action projects in the Environmental Restoration (ER) Program.

  2. First conclusions about results of GPR investigations in the Church of the Assumption of the Blessed Virgin Mary in Kłodzko, Poland

    Directory of Open Access Journals (Sweden)

    A. Chernov

    2018-03-01

    Full Text Available The article presents results of a ground penetrating radar (GPR investigation carried out in the Church of the Assumption of the Blessed Virgin Mary in Kłodzko, Poland, dating from the 14th to 16th centuries. Due to the 20th century wars, the current state of knowledge about the history of the church is still poor. Under the floor of the Catholic temple, unknown structures might exist. To verify the presence of underground structures such as crypts and tombs, a GPR survey was carried out in chapels and aisles with 500 and 800 MHz GPR shielded antennas. Numerous anomalies were detected. It was concluded that those under the chapels were caused by the presence of crypts beneath the floor.

  3. Preliminary results of a multidisciplinary geophysical investigation in an archaeological area near Rome, with remains of a vast imperial age Roman villa

    Science.gov (United States)

    Florindo, F.; Sapia, V.; Marchetti, M.

    2017-12-01

    We present preliminary results of a multidisciplinary geophysical investigation applied to the subsoil imaging of the archaeological site of Cocciano, near Rome. The area was place of a series of archaeological findings, which are generally recognized as the remains of a vast Roman villa of the imperial age, notably attributed to Emperor Tiberius. We acquired capacitive coupled resistivity data along two parallel profiles and we performed a magnetic survey over a small subset of the survey area. The recovered resistivity models suggest the presence of a shallow, sub-horizontal, resistive layer (ρ > 350 Ωm), of slightly variable thickness (2 - 3 m), which we interpret as the response of ancient substructions overlying a relatively low-resistive layer, which we ascribe to the geological substratum. Processed magnetic data show a clear magnetic signature aligned to form a curve-shaped anomaly right at the prosecution of a nearby, partially exposed, ancient wall.

  4. Correlates of joint child protection and police child sexual abuse investigations: results from the Canadian Incidence Study of Reported Child Abuse and Neglect-2008.

    Science.gov (United States)

    Tonmyr, L; Gonzalez, A

    2015-01-01

    Our study examines the frequency of joint investigations by child protection workers and the police in sexual abuse investigations compared to other maltreatment types and the association of child-, caregiver-, maltreatment- and investigation-related characteristics in joint investigations, focussing specifically on investigations involving sexual abuse. We analyzed data from the Canadian Incidence Study of Reported Child Abuse and Neglect-2008 using logistic regression. The data suggest that sexual abuse (55%), and then physical abuse, neglect and emotional maltreatment, are most often co-investigated. Substantiation of maltreatment, severity of maltreatment, placement in out-of-home care, child welfare court involvement and referral of a family member to specialized services was more likely when the police were involved in an investigation. This study adds to the limited information on correlates of joint child protection agency and police investigations. Further research is needed to determine the effectiveness of these joint investigations.

  5. Prevalence of Infraumbilical Adhesions in Women With Previous Laparoscopy

    Science.gov (United States)

    Ku, Lowell; Wong, Herb; Liu, C. Y.; Phelps, John Y.

    2007-01-01

    Background and Objectives: The aim of this study is to evaluate the prevalence of intraabdominal adhesions to the umbilicus following gynecologic laparoscopy through an umbilical incision. Methods: A retrospective review was performed of all gynecologic laparoscopic procedures in a private practice setting to identify patients with a repeat laparoscopy who had a history of a previous laparoscopy through an umbilical incision. Patients with a history of other surgeries were excluded. All repeat laparoscopies used a left upper quadrant entry technique where the abdominal cavity was surveyed for adhesions. We also reviewed adverse events attributable to the left upper quadrant entry approach. Results: We identified 151 patients who underwent a second laparoscopy and had a previous umbilical scar. Thirty-two of the 151 (21.2%) patients with a history of a laparoscopy had evidence of adhesions to the umbilical undersurface. No adverse events or injuries were attributed to the left upper quadrant entry technique. Conclusions: Adhesions to the umbilical undersurface occur in 21.2% of patients who have undergone a prior laparoscopy through an umbilical incision. For this reason, we recommend an alternate location for entry in patients with an umbilical scar from a previous laparoscopy. PMID:17651555

  6. Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus

    Directory of Open Access Journals (Sweden)

    Ann Ray

    2016-07-01

    Full Text Available Members of the genus Vibrio include many pathogens of humans and marine animals that share genetic information via horizontal gene transfer. Hence, the Vibrio pan-genome carries the potential to establish new pathogenic strains by sharing virulence determinants, many of which have yet to be characterized. Here, we investigated the virulence properties of Vibrio proteolyticus, a Gram-negative marine bacterium previously identified as part of the Vibrio consortium isolated from diseased corals. We found that V. proteolyticus causes actin cytoskeleton rearrangements followed by cell lysis in HeLa cells in a contact-independent manner. In search of the responsible virulence factor involved, we determined the V. proteolyticus secretome. This proteomics approach revealed various putative virulence factors, including active type VI secretion systems and effectors with virulence toxin domains; however, these type VI secretion systems were not responsible for the observed cytotoxic effects. Further examination of the V. proteolyticus secretome led us to hypothesize and subsequently demonstrate that a secreted hemolysin, belonging to a previously uncharacterized clan of the leukocidin superfamily, was the toxin responsible for the V. proteolyticus-mediated cytotoxicity in both HeLa cells and macrophages. Clearly, there remains an armory of yet-to-be-discovered virulence factors in the Vibrio pan-genome that will undoubtedly provide a wealth of knowledge on how a pathogen can manipulate host cells.

  7. Effects of Blocked and Random Practice Schedule on Outcomes of Sound Production Treatment for Acquired Apraxia of Speech: Results of a Group Investigation.

    Science.gov (United States)

    Wambaugh, Julie L; Nessler, Christina; Wright, Sandra; Mauszycki, Shannon C; DeLong, Catharine; Berggren, Kiera; Bailey, Dallin J

    2017-06-22

    The purpose of this investigation was to compare the effects of schedule of practice (i.e., blocked vs. random) on outcomes of Sound Production Treatment (SPT; Wambaugh, Kalinyak-Fliszar, West, & Doyle, 1998) for speakers with chronic acquired apraxia of speech and aphasia. A combination of group and single-case experimental designs was used. Twenty participants each received SPT administered with randomized stimuli presentation (SPT-R) and SPT applied with blocked stimuli presentation (SPT-B). Treatment effects were examined with respect to accuracy of articulation as measured in treated and untreated experimental words produced during probes. All participants demonstrated improved articulation of treated items with both practice schedules. Effect sizes were calculated to estimate magnitude of change for treated and untreated items by treatment condition. No significant differences were found for SPT-R and SPT-B relative to effect size. Percent change over the highest baseline performance was also calculated to provide a clinically relevant indication of improvement. Change scores associated with SPT-R were significantly higher than those for SPT-B for treated items but not untreated items. SPT can result in improved articulation regardless of schedule of practice. However, SPT-R may result in greater gains for treated items. https://doi.org/10.23641/asha.5116831.

  8. Weight change and 15 year mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study.

    Science.gov (United States)

    Mulligan, Angela A; Lentjes, Marleen A H; Luben, Robert N; Wareham, Nicholas J; Khaw, Kay-Tee

    2018-01-01

    Studies have reported a higher mortality risk associated with weight loss, particularly in middle-aged and older adults, although some of these studies did find that gaining weight was also associated with an increased mortality risk. We examined changes in weight in relation to mortality in a prospective population-based cohort study of men and women, resident in Norfolk, UK. Participants were assessed at baseline (1993-1997) and at a second examination (1998-2000), as part of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study, and followed up to 2015 for mortality. Participants with a self-reported history of cancer or cardiovascular disease, body mass index  5 kg. Similar associations were observed after excluding deaths in the first 5 years of follow-up. Results for weight gain were inconclusive. We conclude that objectively measured weight loss, but not weight gain, was associated with subsequent higher mortality risk in this population-based study of middle-aged and elderly men and women. However, undiagnosed, pre-existing disease and the inability to account for weight cycling need to be remembered when interpreting these results. Unravelling the causal pathways underlying this association will require more detailed studies, including that of changes in body composition.

  9. Clinical investigation on axial versus tilted implants for immediate fixed rehabilitation of edentulous arches: preliminary results of a single cohort study.

    Science.gov (United States)

    Agnini, Alessandro; Agnini, Andrea Mastrorosa; Romeo, Davide; Chiesi, Manuele; Pariente, Leon; Stappert, Christian F J

    2014-08-01

    The purpose of this clinical investigation was to evaluate full-arch fixed-dental restorations supported by immediate loaded axial and tilted implants in a single-cohort study. Survival rate of axial and tilted implants was compared. From 2006 to 2010, 30 patients were recruited and treated with dental implants. Provisional fixed-dental prostheses were screw-retained over axial or axial and tilted implants within 24 hours after surgery. Follow-ups at 6, 12, and 24 months and annually up to 5 years were scheduled, and radiographic evaluation of peri-implant bone level changes was conducted. Thirty patients (20 females and 10 males) were followed up for an average of 44 months (range 18-67 months). Six patients received both upper and lower implant rehabilitations, resulting in 36 restorations. A total of two hundred two implants were placed (maxilla = 118; mandible = 84) and 46% of the fixtures were evaluated at the 4-year recall. Four axial implants were lost in three patients, leading to 98.02% implant (97.56% axial implants and 100% tilted implants) and 100% prosthetic cumulative survival rate, respectively. No significant difference in marginal bone loss was found between tilted and axial implants in both jaws at 1-year evaluation. Midterm results confirmed that immediate loading of axial and tilted implants provides a viable treatment modality for the rehabilitation of edentulous arches. © 2012 Wiley Periodicals, Inc.

  10. Effect of booster doses of poliovirus vaccine in previously vaccinated children, Clinical Trial Results 2013.

    Science.gov (United States)

    Habib, Muhammad Atif; Soofi, Sajid; Mach, Ondrej; Samejo, Tariq; Alam, Didar; Bhatti, Zaid; Weldon, William C; Oberste, Steven M; Sutter, Roland; Bhutta, Zulfiqar A

    2016-07-19

    Considering the current polio situation Pakistan needs vaccine combinations to reach maximum population level immunity. The trial assessed whether inactivated poliovirus vaccine (IPV) can be used to rapidly boost immunity among children in Pakistan. A five-arm randomized clinical trial was conducted among children (6-24months, 5-6years and 10-11years). Children were randomized in four intervention arms as per the vaccines they received (bOPV, IPV, bOPV+vitamin A, and bOPV+IPV) and a control arm which did not receive any vaccine. Baseline seroprevalence of poliovirus antibodies and serological immune response 28days after intervention were assessed. The baseline seroprevalence was high for all serotypes and the three age groups [PV1: 97%, 100%, 96%, PV2: 86%, 100%, 99%, PV3: 83%, 95%, 87% for the three age groups respectively]. There was significantly higher rate of immune response observed in the study arms which included IPV (95-99%) compared with bOPV only arms (11-43%), [p0.5]. IPV has shown the ability to efficiently close existing immunity gaps in a vulnerable population of children in rural Pakistan. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Cutaneous protothecosis in a patient with previously undiagnosed HIV infection.

    Science.gov (United States)

    Fong, Kenneth; Tee, Shang-Ian; Ho, Madeline S L; Pan, Jiun Yit

    2015-08-01

    Protothecosis is an uncommon condition resulting from infection by achlorophyllous algae of the Prototheca species. Immunocompromised individuals are generally most susceptible to protothecal infection and tend to develop severe and disseminated disease. However, the association between protothecosis and HIV-induced immunosuppression is not clear, with only a handful of cases having been described to date. Here we report a case of cutaneous protothecosis in a Chinese man with previously undiagnosed HIV infection that responded well to oral itraconazole. © 2014 The Australasian College of Dermatologists.

  12. Typing DNA profiles from previously enhanced fingerprints using direct PCR.

    Science.gov (United States)

    Templeton, Jennifer E L; Taylor, Duncan; Handt, Oliva; Linacre, Adrian

    2017-07-01

    Fingermarks are a source of human identification both through the ridge patterns and DNA profiling. Typing nuclear STR DNA markers from previously enhanced fingermarks provides an alternative method of utilising the limited fingermark deposit that can be left behind during a criminal act. Dusting with fingerprint powders is a standard method used in classical fingermark enhancement and can affect DNA data. The ability to generate informative DNA profiles from powdered fingerprints using direct PCR swabs was investigated. Direct PCR was used as the opportunity to generate usable DNA profiles after performing any of the standard DNA extraction processes is minimal. Omitting the extraction step will, for many samples, be the key to success if there is limited sample DNA. DNA profiles were generated by direct PCR from 160 fingermarks after treatment with one of the following dactyloscopic fingerprint powders: white hadonite; silver aluminium; HiFi Volcano silk black; or black magnetic fingerprint powder. This was achieved by a combination of an optimised double-swabbing technique and swab media, omission of the extraction step to minimise loss of critical low-template DNA, and additional AmpliTaq Gold ® DNA polymerase to boost the PCR. Ninety eight out of 160 samples (61%) were considered 'up-loadable' to the Australian National Criminal Investigation DNA Database (NCIDD). The method described required a minimum of working steps, equipment and reagents, and was completed within 4h. Direct PCR allows the generation of DNA profiles from enhanced prints without the need to increase PCR cycle numbers beyond manufacturer's recommendations. Particular emphasis was placed on preventing contamination by applying strict protocols and avoiding the use of previously used fingerprint brushes. Based on this extensive survey, the data provided indicate minimal effects of any of these four powders on the chance of obtaining DNA profiles from enhanced fingermarks. Copyright © 2017

  13. Paediatric multidetector CT optimisation training: a survey of common scanning procedures and the resultant dose reduction associated with paediatric MDCT investigations in Australia

    International Nuclear Information System (INIS)

    Wallace, Anthony; Sibelle, Kimberly; Stanley, Martin; Budd, Ray; Goergen, Stacey; Heggie, John

    2008-01-01

    The growing recognition of the increased risk of stochastic injury to paediatric patients from multidetector CT (MDCT) investigations prompted a survey sponsored by Royal Australian and New Zealand College of Radiology (RANZCR), Austin Health and Monash University to initiate a national paediatric dosimetry review for some of the most common investigations undertaken in MDCT paediatric practice. The survey forms included a data sheet requiring acquisition protocol parameters and a phantom graphic sheet requiring the marking of the inferior and superior acquisition margins. Survey forms were supplied for each of 13 common MDCT acquisitions to be tested. Response data was input into CT-Expo Version 1.5.1., a CT dosimetry calculation engine, to determine dose length product (DLP (mGy.cm)) and effective dose (ED (mSv)). Initial survey data was collected, calculated, blinded and collated into various presentations that were given at a MDCT optimisation seminar in November, 2006. All sites were re-surveyed in May 2007 and doses calculated. Initial survey data showed a range of dose efficiencies spread across the surveyed sites. A measure of the initial spread of DLP values per procedure ranged from a minimum of less than 2 for a head-trauma acquisition (372 - 520 mGy.cm) to 14 for a chest-trauma acquisition (28 - 388 mGy.cm). Results of the 2nd survey strongly indicate that the application of optimisation training to paediatric MDCT scanning can produce significant dose savings by the application of simple dose saving strategies. Many protocols demonstrated dose reductions of greater than 50% with significant reductions in both the maximum and minimum values of calculated DLP and ED. The development of a survey-training-resurvey model of MDCT optimisation has proven to be a successful strategy for paediatric MDCT dose reduction in Australia. (author)

  14. Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus.

    Science.gov (United States)

    Ray, Ann; Kinch, Lisa N; de Souza Santos, Marcela; Grishin, Nick V; Orth, Kim; Salomon, Dor

    2016-07-26

    Members of the genus Vibrio include many pathogens of humans and marine animals that share genetic information via horizontal gene transfer. Hence, the Vibrio pan-genome carries the potential to establish new pathogenic strains by sharing virulence determinants, many of which have yet to be characterized. Here, we investigated the virulence properties of Vibrio proteolyticus, a Gram-negative marine bacterium previously identified as part of the Vibrio consortium isolated from diseased corals. We found that V. proteolyticus causes actin cytoskeleton rearrangements followed by cell lysis in HeLa cells in a contact-independent manner. In search of the responsible virulence factor involved, we determined the V. proteolyticus secretome. This proteomics approach revealed various putative virulence factors, including active type VI secretion systems and effectors with virulence toxin domains; however, these type VI secretion systems were not responsible for the observed cytotoxic effects. Further examination of the V. proteolyticus secretome led us to hypothesize and subsequently demonstrate that a secreted hemolysin, belonging to a previously uncharacterized clan of the leukocidin superfamily, was the toxin responsible for the V. proteolyticus-mediated cytotoxicity in both HeLa cells and macrophages. Clearly, there remains an armory of yet-to-be-discovered virulence factors in the Vibrio pan-genome that will undoubtedly provide a wealth of knowledge on how a pathogen can manipulate host cells. The pan-genome of the genus Vibrio is a potential reservoir of unidentified toxins that can provide insight into how members of this genus have successfully risen as emerging pathogens worldwide. We focused on Vibrio proteolyticus, a marine bacterium that was previously implicated in virulence toward marine animals, and characterized its interaction with eukaryotic cells. We found that this bacterium causes actin cytoskeleton rearrangements and leads to cell death. Using a

  15. HEART TRANSPLANTATION IN PATIENTS WITH PREVIOUS OPEN HEART SURGERY

    Directory of Open Access Journals (Sweden)

    R. Sh. Saitgareev

    2016-01-01

    Full Text Available Heart Transplantation (HTx to date remains the most effective and radical method of treatment of patients with end-stage heart failure. The defi cit of donor hearts is forcing to resort increasingly to the use of different longterm mechanical circulatory support systems, including as a «bridge» to the follow-up HTx. According to the ISHLT Registry the number of recipients underwent cardiopulmonary bypass surgery increased from 40% in the period from 2004 to 2008 to 49.6% for the period from 2009 to 2015. HTx performed in repeated patients, on the one hand, involves considerable technical diffi culties and high risks; on the other hand, there is often no alternative medical intervention to HTx, and if not dictated by absolute contradictions the denial of the surgery is equivalent to 100% mortality. This review summarizes the results of a number of published studies aimed at understanding the immediate and late results of HTx in patients, previously underwent open heart surgery. The effect of resternotomy during HTx and that of the specifi c features associated with its implementation in recipients previously operated on open heart, and its effects on the immediate and long-term survival were considered in this review. Results of studies analyzing the risk factors for perioperative complications in repeated recipients were also demonstrated. Separately, HTx risks after implantation of prolonged mechanical circulatory support systems were examined. The literature does not allow to clearly defi ning the impact factor of earlier performed open heart surgery on the course of perioperative period and on the prognosis of survival in recipients who underwent HTx. On the other hand, subject to the regular fl ow of HTx and the perioperative period the risks in this clinical situation are justifi ed as a long-term prognosis of recipients previously conducted open heart surgery and are comparable to those of patients who underwent primary HTx. Studies

  16. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

    Science.gov (United States)

    Mavaddat, Nasim; Barrowdale, Daniel; Andrulis, Irene L.; Domchek, Susan M.; Eccles, Diana; Nevanlinna, Heli; Ramus, Susan J.; Spurdle, Amanda; Robson, Mark; Sherman, Mark; Mulligan, Anna Marie; Couch, Fergus J.; Engel, Christoph; McGuffog, Lesley; Healey, Sue; Sinilnikova, Olga M.; Southey, Melissa C.; Terry, Mary Beth; Goldgar, David; O’Malley, Frances; John, Esther M.; Janavicius, Ramunas; Tihomirova, Laima; Hansen, Thomas v O; Nielsen, Finn C.; Osorio, Ana; Stavropoulou, Alexandra; Benítez, Javier; Manoukian, Siranoush; Peissel, Bernard; Barile, Monica; Volorio, Sara; Pasini, Barbara; Dolcetti, Riccardo; Putignano, Anna Laura; Ottini, Laura; Radice, Paolo; Hamann, Ute; Rashid, Muhammad U.; Hogervorst, Frans B.; Kriege, Mieke; van der Luijt, Rob B.; Peock, Susan; Frost, Debra; Evans, D. Gareth; Brewer, Carole; Walker, Lisa; Rogers, Mark T.; Side, Lucy E.; Houghton, Catherine; Weaver, JoEllen; Godwin, Andrew K.; Schmutzler, Rita K.; Wappenschmidt, Barbara; Meindl, Alfons; Kast, Karin; Arnold, Norbert; Niederacher, Dieter; Sutter, Christian; Deissler, Helmut; Gadzicki, Doroteha; Preisler-Adams, Sabine; Varon-Mateeva, Raymonda; Schönbuchner, Ines; Gevensleben, Heidrun; Stoppa-Lyonnet, Dominique; Belotti, Muriel; Barjhoux, Laure; Isaacs, Claudine; Peshkin, Beth N.; Caldes, Trinidad; de al Hoya, Miguel; Cañadas, Carmen; Heikkinen, Tuomas; Heikkilä, Päivi; Aittomäki, Kristiina; Blanco, Ignacio; Lazaro, Conxi; Brunet, Joan; Agnarsson, Bjarni A.; Arason, Adalgeir; Barkardottir, Rosa B.; Dumont, Martine; Simard, Jacques; Montagna, Marco; Agata, Simona; D’Andrea, Emma; Yan, Max; Fox, Stephen; Rebbeck, Timothy R.; Rubinstein, Wendy; Tung, Nadine; Garber, Judy E.; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S.; Lindor, Noralane M.; Szabo, Csilla; Offit, Kenneth; Sakr, Rita; Gaudet, Mia M.; Singer, Christian F.; Tea, Muy-Kheng; Rappaport, Christine; Mai, Phuong L.; Greene, Mark H.; Sokolenko, Anna; Imyanitov, Evgeny; Toland, Amanda Ewart; Senter, Leigha; Sweet, Kevin; Thomassen, Mads; Gerdes, Anne-Marie; Kruse, Torben; Caligo, Maria; Aretini, Paolo; Rantala, Johanna; von Wachenfeld, Anna; Henriksson, Karin; Steele, Linda; Neuhausen, Susan L.; Nussbaum, Bob; Beattie, Mary; Odunsi, Kunle; Sucheston, Lara; Gayther, Simon A; Nathanson, Kate; Gross, Jenny; Walsh, Christine; Karlan, Beth; Chenevix-Trench, Georgia; Easton, Douglas F.; Antoniou, Antonis C.

    2011-01-01

    Background Previous small studies found that BRCA1 and BRCA2 breast tumors differ in their pathology. Analysis of larger datasets of mutation carriers should allow further tumor characterization. Methods We used data from 4,325 BRCA1 and 2,568 BRCA2 mutation carriers to analyze the pathology of invasive breast, ovarian and contralateral breast cancers. Results There was strong evidence that the proportion of estrogen receptor (ER)-negative breast tumors decreased with age at diagnosis among BRCA1 (p-trend=1.2×10−5) but increased with age at diagnosis among BRCA2 carriers (p-trend=6.8×10−6). The proportion of triple negative tumors decreased with age at diagnosis in BRCA1 carriers but increased with age at diagnosis of BRCA2 carriers. In both BRCA1 and BRCA2 carriers, ER-negative tumors were of higher histological grade than ER-positive tumors (Grade 3 vs. Grade 1, p=1.2×10−13 for BRCA1 and p=0.001 for BRCA2). ER and progesterone receptor (PR) expression were independently associated with mutation carrier status (ER-positive odds ratio (OR) for BRCA2=9.4, 95%CI:7.0-12.6 and PR-positive OR=1.7, 95%CI:1.3-2.3, under joint analysis). Lobular tumors were more likely to be BRCA2-related (OR for BRCA2=3.3, 95%CI:2.4-4.4, p=4.4×10−14), and medullary tumors BRCA1-related (OR for BRCA2=0.25, 95%CI:0.18-0.35, p=2.3×10−15). ER-status of the first breast cancer was predictive of ER-status of asynchronous contralateral breast cancer (p=0.0004 for BRCA1; p=0.002 for BRCA2). There were no significant differences in ovarian cancer morphology between BRCA1 and BRCA2 carriers (serous:67%; mucinous:1%; endometriod:12%; clear-cell:2%). Conclusions/Impact Pathology characteristics of BRCA1 and BRCA2 tumors may be useful for improving risk prediction algorithms and informing clinical strategies for screening and prophylaxis. PMID:22144499

  17. Investigating the deep internal structure and the heterogeneous margins of the enigmatic Demerara plateau using deep penetrating seismic methods: first results of the MARGATS cruise

    Science.gov (United States)

    Graindorge, David; Walter, Roest; Klingelhoefer, Frauke; Loncke, Lies; Basile, Christophe; Poetisi, Ewald; Deverchère, Jacques; Frédéric Lebrun, Jean; Heuret, Arnauld; Perrot, Julie; Apprioual, Ronan; Crozon, Jacques; Fabre, Maud; Fernagu, Philippe; Guyavarch, Pierre; Prunier, Christophe

    2017-04-01

    The MARGATS scientific cruise was carried out from October 20th to November 16th 2016 on board the R/V L'Atalante, in the Exclusive Economic Zones of Suriname and French Guiana. This cruise is part of a program dedicated to geological investigations of the continental margin, including the Demerara plateau, following the GUYAPLAC (2003), IGUANES (2013) and DRADEMcruises (2016). The aim of MARGATS was to image the internal structure of the Demerara plateau and its different margins using coincident deep penetrating wide angle refraction and multi channel reflection seismic (MCS) methods. During the MARGATS experiment 171 OBSs were deployed distributed along 4 wide-angle lines. Along each wide angle line we also recorded coincident MCS data using a 3 km 480 channel streamer. The dataset was completed by three MCS lines along the eastern part of the Demerara plateau. MCS MAR007 line which is coincident with line OBS MAR-3 was extended on land by a set of 13 land stations deployed along the Maroni River. This line, together with MCS MAR001 and the coincident OBS MAR-1 line reveal the highly homogeneous deep structure of the internal part of the plateau. MCS MAR005 line, which is coincident with OBS MAR-2, MCS MAR006 line coincident with OBS MAR-4, MCS MAR002, MCS MAR003 and MCS MAR004 help to elucidate the structural complexity of the northern transform margin and the eastern divergent margin of the plateau. These new datasets will be highly complementary to the DRADEM dredges results which provide evidence for huge vertical displacements along the transform margin. This EGU session will be the first opportunity to reveal the exceptional quality of the seismic data, after the initial processing steps and the new emergent results conditioning our understanding of the Demarara plateau and its margins.

  18. Molecular characterisation of human Shiga toxin-producing Escherichia coli O26 strains: results of an outbreak investigation, Romania, February to August 2016.

    Science.gov (United States)

    Usein, Codruţa-Romaniţa; Ciontea, Adriana Simona; Militaru, Cornelia Mãdãlina; Condei, Maria; Dinu, Sorin; Oprea, Mihaela; Cristea, Daniela; Michelacci, Valeria; Scavia, Gaia; Zota, Lavinia Cipriana; Zaharia, Alina; Morabito, Stefano

    2017-11-01

    IntroductionAt the beginning of 2016, an increase in paediatric haemolytic uremic syndrome (HUS) cases was observed in Romania. The microbiological investigations allowed isolation of Shiga toxin-producing Escherichia coli (STEC) O26 as the causative agent from most cases. Methods: An enhanced national surveillance of HUS and severe diarrhoea was established across the country following the identification of the first cases and was carried out until August 2016. A total of 15 strains were isolated from 10 HUS and five diarrhoea cases. Strains were characterised by virulence markers (i.e. stx type/subtype, eae , ehxA genes), phylogroup, genetic relatedness and clonality using PCR-based assays, PFGE and multilocus sequence typing (MLST). The first six strains were further characterised by whole genome sequencing (WGS). Results: Five PCR-defined genotypes were distinguished. All strains from HUS cases harboured stx2a and eae , with or without stx1a , while strains from diarrhoea cases carried exclusively stx1a and eae genes. PFGE resolved strains into multiple pulsotypes, compatible with a certain geographic segregation of the cases, and strains were assigned to phylogroup B1 and sequence type (ST) 21. WGS confirmed the results of conventional molecular methods, brought evidence of O26:H11 serotype, and complemented the virulence profiles. Discussion/conclusion: This first description of STEC O26 strains from cases in Romania showed that the isolates belonged to a diverse population. The virulence content of most strains highlighted a high risk for severe outcome in infected patients. Improving the national surveillance strategy for STEC infections in Romania needs to be further considered.

  19. The Results of the CCI-3 Reactor Material Experiment Investigating 2-D Core-Concrete Interaction and Debris Coolability with a Siliceous Concrete Crucible

    International Nuclear Information System (INIS)

    Farmer, M.T.; Lomperski, S.; Basu, S.

    2006-01-01

    The OECD-sponsored Melt Coolability and Concrete Interaction (MCCI) program conducted reactor materials experiments and associated analysis to achieve the following two objectives: 1) resolve the ex-vessel debris coolability issue, and 2) address remaining uncertainties related to long-term two-dimensional molten core-concrete interactions under both wet and dry cavity conditions. Achievement of these two objectives will demonstrate the efficacy of severe accident management guidelines for existing plants, and provide the technical basis for better containment designs of future plants. With respect to the second objective, there are remaining uncertainties in the models that evaluate the lateral vs. axial power split during core-concrete interaction because of a lack of truly two-dimensional experiment data. As a result, there are differences in the 2-D cavity erosion profiles predicted by codes such as WECHSL, COSACO, TOLBIAC, MEDICIS, and MELCOR. In the continuing effort to bridge this data gap, the third in a series of large scale Core-Concrete Interaction experiments (CCI-3) has been conducted as part of the MCCI program. This test investigated the long-term interaction of a 375 kg core-oxide melt within a two-dimensional siliceous concrete crucible. The initial phase of the test was conducted under dry conditions. After a predetermined time interval, the cavity was flooded with water to obtain data on the coolability of a core melt after core-concrete interaction has progressed for some time. This paper provides a description of the facility and an overview of results from this test. (authors)

  20. A 470 x 235 ppi LCD for high-resolution 2D and 3D autostereoscopic display and user aptitude investigation results for mobile phone applications

    Science.gov (United States)

    Takanashi, Nobuaki; Uehara, Shin-ichi; Asada, Hideki

    2007-02-01

    Although interest in 3D displays that don't require special glasses is growing, developers of 3D displays still face many challenges, such as resolution loss in 3D and 3D/2D convertibility. We have solved these problems with the development of a novel pixel arrangement, called Horizontally Double-Density Pixels (HDDP). In this structure, two pictures (one for the left and one for the right eye) on two adjacent pixels form one square 3D pixel. This doubles the 3D resolution, making it as high as the 2D display and shows 3D images anywhere in 2D images with the same resolution. The display we have developed is lenticular lens based, is 2.5 diagonal inches in size, and has a 320x2 (RL) x 480x3 (RGB) resolution. As a 3D display, the horizontal and vertical resolutions are equal (235 ppi each). A user aptitude investigation was conducted for mobile phone applications. Several kinds of 3D pictures were presented to 345 participants, whose ages ranged from 16 to 54, and their preferences were surveyed. 3D pictures were categorized into three application areas: communication, entertainment, and useful tools in the mobile environment. Eighteen examples of possible 3D applications were listed and put to the vote. The results showed a high acceptance of and interest in this mobile 3D display.

  1. Results of Investigations on the Blink Reflex as a Protective Means against Laser and LED Radiation: A Description Based on Fundamental Psychophysical Laws

    International Nuclear Information System (INIS)

    Hans-Dieter Reidenbach

    2006-01-01

    2,650 volunteers have been investigated in blink-reflex studies with various test equipment, where a laser beam or a single element L.E.D. or an array have been used to irradiate the human eye in order to initiate a physiological reaction. In addition 1,196 volunteers took part in aversion response studies. 491 persons out of 2,650, i.e., 18.53 %, showed a blink reflex or lid closure, upon exposure to irradiation from a laser or an L.E.D.. Only 6.19 %, i. e., 74 out of 1,196 volunteers, showed other aversion responses, like gross eye or head movements. The different parameters which are mainly responsible for the respective results concerning the blink reflex will be dealt with and explained, as they have been achieved up to now. In addition some experimentally verified dependencies on fundamental psychophysical laws will be described. Besides the statement that the blink reflex should not be used as a sufficient physiological protective means it can be generally stated that in order to ensure their safety, in spite of the missing blink-reflex and other aversion responses, users of low-power lasers should be instructed to perform active protective reactions, e.g., to close the eyes voluntarily and simultaneously move the head away from the beam in the case of an unintentional exposure or intrabeam viewing. (author)

  2. Anorexia, functional capacity, and clinical outcome in patients with chronic heart failure: results from the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF)

    Science.gov (United States)

    Saitoh, Masakazu; dos Santos, Marcelo R.; Emami, Amir; Ishida, Junichi; Ebner, Nicole; Valentova, Miroslava; Bekfani, Tarek; Sandek, Anja; Lainscak, Mitja; Doehner, Wolfram; Anker, Stefan D.

    2017-01-01

    Abstract Aims We aimed to assess determinants of anorexia, that is loss of appetite in patients with heart failure (HF) and aimed to further elucidate the association between anorexia, functional capacity, and outcomes in affected patients. Methods and results We assessed anorexia status among 166 patients with HF (25 female, 66 ± 12 years) who participated in the Studies Investigating Co‐morbidities Aggravating HF. Anorexia was assessed by a 6‐point Likert scale (ranging from 0 to 5), wherein values ≥1 indicate anorexia. Functional capacity was assessed as peak oxygen uptake (peak VO2), 6 min walk test, and short physical performance battery test. A total of 57 patients (34%) reported any anorexia, and these patients showed lower values of peak VO2, 6 min walk distance, and short physical performance battery score (all P anorexia. A total of 22 patients (13%) died during a mean follow‐up of 22.5 ± 5.1 months. Kaplan‐Meier curves for cumulative survival showed that those patients with anorexia presented higher mortality (Log‐rank test P = 0.03). Conclusions Inflammation, use of loop diuretics, and cachexia are associated with an increased likelihood of anorexia in patients with HF, and patients with anorexia showed impaired functional capacity and poor outcomes. PMID:28960880

  3. Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation for Locoregionally Advanced Head and Neck Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Seiwert, Tanguy Y., E-mail: tseiwert@medicine.bsd.uchicago.edu [Departments of Medicine, University of Chicago, Chicago, Illinois (United States); Melotek, James M. [Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois (United States); Blair, Elizabeth A. [Department of Otolaryngology, University of Chicago, Chicago, Illinois (United States); Stenson, Kerstin M. [Department of Otolaryngology, Rush University, Chicago, Illinois (United States); Salama, Joseph K. [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Witt, Mary Ellyn [Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois (United States); Brisson, Ryan J.; Chawla, Apoorva; Dekker, Allison [Departments of Medicine, University of Chicago, Chicago, Illinois (United States); Lingen, Mark W. [Department of Pathology, University of Chicago, Chicago, Illinois (United States); Kocherginsky, Masha [Department of Public Health Sciences, University of Chicago, Chicago, Illinois (United States); Villaflor, Victoria M. [Departments of Medicine, University of Chicago, Chicago, Illinois (United States); Cohen, Ezra E.W. [Moores Cancer Center, University of California, San Diego, San Diego, California (United States); Haraf, Daniel J. [Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois (United States); Vokes, Everett E. [Departments of Medicine, University of Chicago, Chicago, Illinois (United States)

    2016-09-01

    Purpose: The role of cetuximab in the treatment of locoregionally advanced head and neck squamous cell cancer (LA-HNSCC) remains poorly defined. In this phase 2 randomized study, we investigated the addition of cetuximab to both induction chemotherapy (IC) and hyperfractionated or accelerated chemoradiation. Methods and Materials: Patients with LA-HNSCC were randomized to receive 2 cycles of weekly IC (cetuximab, paclitaxel, carboplatin) and either Cetux-FHX (concurrent cetuximab, 5-fluorouracil, hydroxyurea, and 1.5 Gy twice-daily radiation therapy every other week to 75 Gy) or Cetux-PX (cetuximab, cisplatin, and accelerated radiation therapy with delayed concomitant boost to 72 Gy in 42 fractions). The primary endpoint was progression-free survival (PFS), with superiority compared with historical control achieved if either arm had 2-year PFS ≥70%. Results: 110 patients were randomly assigned to either Cetux-FHX (n=57) or Cetux-PX (n=53). The overall response rate to IC was 91%. Severe toxicity on IC was limited to rash (23% grade ≥3) and myelosuppression (38% grade ≥3 neutropenia). The 2-year rates of PFS for both Cetux-FHX (82.5%) and Cetux-PX (84.9%) were significantly higher than for historical control (P<.001). The 2-year overall survival (OS) was 91.2% for Cetux-FHX and 94.3% for Cetux-PX. With a median follow-up time of 72 months, there were no significant differences in PFS (P=.35) or OS (P=.15) between the treatment arms. The late outcomes for the entire cohort included 5-year PFS, OS, locoregional failure, and distant metastasis rates of 74.1%, 80.3%, 15.7%, and 7.4%, respectively. The 5-year PFS and OS were 84.4% and 91.3%, respectively, among human papillomavirus (HPV)-positive patients and 65.9% and 72.5%, respectively, among HPV-negative patients. Conclusions: The addition of cetuximab to IC and chemoradiation was tolerable and produced long-term control of LA-HNSCC, particularly among poor-prognosis HPV-negative patients. Further

  4. Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation for Locoregionally Advanced Head and Neck Cancer

    International Nuclear Information System (INIS)

    Seiwert, Tanguy Y.; Melotek, James M.; Blair, Elizabeth A.; Stenson, Kerstin M.; Salama, Joseph K.; Witt, Mary Ellyn; Brisson, Ryan J.; Chawla, Apoorva; Dekker, Allison; Lingen, Mark W.; Kocherginsky, Masha; Villaflor, Victoria M.; Cohen, Ezra E.W.; Haraf, Daniel J.; Vokes, Everett E.

    2016-01-01

    Purpose: The role of cetuximab in the treatment of locoregionally advanced head and neck squamous cell cancer (LA-HNSCC) remains poorly defined. In this phase 2 randomized study, we investigated the addition of cetuximab to both induction chemotherapy (IC) and hyperfractionated or accelerated chemoradiation. Methods and Materials: Patients with LA-HNSCC were randomized to receive 2 cycles of weekly IC (cetuximab, paclitaxel, carboplatin) and either Cetux-FHX (concurrent cetuximab, 5-fluorouracil, hydroxyurea, and 1.5 Gy twice-daily radiation therapy every other week to 75 Gy) or Cetux-PX (cetuximab, cisplatin, and accelerated radiation therapy with delayed concomitant boost to 72 Gy in 42 fractions). The primary endpoint was progression-free survival (PFS), with superiority compared with historical control achieved if either arm had 2-year PFS ≥70%. Results: 110 patients were randomly assigned to either Cetux-FHX (n=57) or Cetux-PX (n=53). The overall response rate to IC was 91%. Severe toxicity on IC was limited to rash (23% grade ≥3) and myelosuppression (38% grade ≥3 neutropenia). The 2-year rates of PFS for both Cetux-FHX (82.5%) and Cetux-PX (84.9%) were significantly higher than for historical control (P<.001). The 2-year overall survival (OS) was 91.2% for Cetux-FHX and 94.3% for Cetux-PX. With a median follow-up time of 72 months, there were no significant differences in PFS (P=.35) or OS (P=.15) between the treatment arms. The late outcomes for the entire cohort included 5-year PFS, OS, locoregional failure, and distant metastasis rates of 74.1%, 80.3%, 15.7%, and 7.4%, respectively. The 5-year PFS and OS were 84.4% and 91.3%, respectively, among human papillomavirus (HPV)-positive patients and 65.9% and 72.5%, respectively, among HPV-negative patients. Conclusions: The addition of cetuximab to IC and chemoradiation was tolerable and produced long-term control of LA-HNSCC, particularly among poor-prognosis HPV-negative patients. Further

  5. A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons

    OpenAIRE

    Javier Rodríguez Villanueva; Jorge Martín Esteban; Laura Rodríguez Villanueva

    2017-01-01

    Despite the wide variety of pharmacological activities described for the Marrubium vulgare L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should Marrubium vulgare be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical...

  6. Investigation of the exposure to radon and progeny in the thermal spas of Loutraki (Attica-Greece): Results from measurements and modelling

    International Nuclear Information System (INIS)

    Nikolopoulos, Dimitrios; Vogiannis, Efstratios; Petraki, Ermioni; Zisos, Athanasios; Louizi, Anna

    2010-01-01

    Radon and progeny ( 218 Po, 214 Pb, 214 Bi and 214 Po) in thermal spas are well known radioactive pollutants identified for additional radiation burden of patients due to the activity concentration peaks which appear during bath treatment or due to drinking of waters of high radon content. This burden affects additionally the working personnel of the spas. The present paper has focused on the thermal spas of Loutraki (Attica-Greece). The aim was the investigation of the health impact for patients and working personnel due to radon and progeny. Attention has been paid to radon and progeny transient concentration peaks (for bath treatment) and to radon of thermal waters (both for bath treatment and drinking therapy). Designed experiments have been carried out, which included radon and progeny activity concentration measurements in thermal waters and ambient air. Additionally, published models for description of radon and progeny transient concentration peaks were employed. The models were based on physicochemical processes involved and employed non linear first order derivative mass balance differential equations which were solved numerically with the aid of specially developed computer codes. The collected measurements were analysed incorporating these models. Results were checked via non linear statistical tests. Predictions and measurements were found in close agreement. Non linear parameters were estimated. The models were employed for dosimetric estimations of patients and working personnel. The effective doses of patients receiving bath treatment were found low but not negligible. The corresponding doses to patients receiving potable treatment were found high but below the proposed international limits. It was found that the working personnel are exposed to considerable effective doses, however well below the acceptable limits for workers. It was concluded that treatment and working in the Loutraki spas leads to intense variations of radon and progeny and

  7. Incidence of Acneform Lesions in Previously Chemically Damaged Persons-2004

    Directory of Open Access Journals (Sweden)

    N Dabiri

    2008-04-01

    Full Text Available ABSTRACT: Introduction & Objective: Chemical gas weapons especially nitrogen mustard which was used in Iraq-Iran war against Iranian troops have several harmful effects on skin. Some other chemical agents also can cause acne form lesions on skin. The purpose of this study was to compare the incidence of acneform in previously chemically damaged soldiers and non chemically damaged persons. Materials & Methods: In this descriptive and analytical study, 180 chemically damaged soldiers, who have been referred to dermatology clinic between 2000 – 2004, and forty non-chemically damaged people, were chosen randomly and examined for acneform lesions. SPSS software was used for statistic analysis of the data. Results: The mean age of the experimental group was 37.5 ± 5.2 and that of the control group was 38.7 ± 5.9 years. The mean percentage of chemical damage in cases was 31 percent and the time after the chemical damage was 15.2 ± 1.1 years. Ninety seven cases (53.9 percent of the subjects and 19 people (47.5 percent of the control group had some degree of acne. No significant correlation was found in incidence, degree of lesions, site of lesions and age of subjects between two groups. No significant correlation was noted between percentage of chemical damage and incidence and degree of lesions in case group. Conclusion: Incidence of acneform lesions among previously chemically injured peoples was not higher than the normal cases.

  8. Intravitreal ranibizumab for diabetic macular oedema in previously vitrectomized eyes

    DEFF Research Database (Denmark)

    Laugesen, Caroline Schmidt; Ostri, Christoffer; Brynskov, Troels

    2017-01-01

    PURPOSE: There is little information about the efficacy of intravitreal vascular endothelial growth factor (VEGF) inhibition in vitrectomized eyes. This study aimed to evaluate the efficacy of anti-VEGF (ranibizumab) on diabetic macular oedema in previously vitrectomized eyes. METHODS: A nationwide...... retrospective review of medical records from 2010 to 2013. RESULTS: We identified 33 previously vitrectomized eyes in 28 patients treated with ranibizumab injections for diabetic macular oedema. Median follow-up was 323 days (interquartile range 72-1404 days). Baseline mean visual acuity was 0.57 logMAR (95% CI...... 0.13-1.01) before injections. After an average of 4.7 injections (range 1-15), mean visual acuity remained stable at 0.54 logMAR (95% CI 0.13-0.95) with a mean improvement of 0.03 (p = 0. 45, 95% CI -0.12 to 0.06). In 12 eyes (36%), visual acuity improved 0.1 logMAR or more, in 12 eyes (36%), vision...

  9. Efforts to promote vaginal delivery after a previous cesarean section.

    Science.gov (United States)

    Hamai, Yoko; Imanishi, Yukio

    2012-01-01

    The aim of this study was to examine the results of vaginal delivery in patients with a past history of cesarean section. The type of delivery, interventions during delivery, and the prognoses of the mothers and babies were examined in 145 women with a history of cesarean section over the 10-year period from January 2000 to December 2009. A scheduled cesarean section was performed in 27 cases. Vaginal delivery was recommended in 118 cases and the success rate was 94.9% (112/118). Uterine rupture was observed in one patient who experienced a natural rupture at home and whose previous cesarean section was an inverse T incision. No cases required a blood transfusion or hysterectomy. The prognoses of both mothers and babies were good and the vaginal delivery success rate was 94.9%. Uterine rupture was observed in one case. Vaginal delivery with previous cesarean section should be considered in cases with expectation and informed consent. © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

  10. Forsmark site investigation. Hydrochemical monitoring of groundwaters and surface waters. Results from water sampling in the Forsmark area, January-December 2009

    Energy Technology Data Exchange (ETDEWEB)

    Nilsson, Ann-Chatrin (ed.); Berg, Cecilia; Harrstroem, Johan; Joensson, Stig; Thur, Pernilla (Geosigma AB (Sweden)); Borgiel, Micke; Qvarfordt, Susanne (Sveriges Vattenekologer AB (Sweden))

    2010-09-15

    The fifth year (2009) of hydrochemical monitoring of groundwaters, surface waters and precipitation in Forsmark is documented in the report. The hydrochemical monitoring programme 2009 included water sampling from: - percussion- and core boreholes equipped with installations for long-term pressure monitoring, tracer tests and water sampling in packed off borehole sections, sampling and analysis performed twice (spring and autumn), - near surface groundwaters (sampling four times a year), - private wells (once per year in October), - surface waters (eleven sampling occasions per year). Due to the somewhat different performance of the hydrogeochemical monitoring of the deep groundwaters during the autumn 2009 compared to previous years, some new findings and knowledge were obtained: 1) Removal of water volumes corresponding to three to five times the volume of the borehole section (the routine procedure) is seldom enough to obtain a complete exchange of the water present in the borehole section when the pumping starts. 2) It is likely that the elevated sulphide concentrations observed in the monitoring programme /1/ is due to contamination from initial water present in the borehole sections when the pumping starts. This water may have a very high sulphide concentration. Dirty water in tubes and in stand pipes may also contribute to the enhanced sulphide concentration. 3) Plug flow calculations will be introduced in the future as a new routine procedure to estimate the water volumes to be removed, in order to exchange the section water volume, prior to groundwater sampling in delimited borehole sections. During the autumn sampling, sample series of five samples per sampling location were collected during continuous pumping in thirteen selected borehole sections. Furthermore, special efforts were put on cleaning of stand pipes and exchange of water prior to sampling. The analytical protocol was rather extensive and included sulphide and uranium analyses for each sample

  11. Forsmark site investigation. Hydrochemical monitoring of groundwaters and surface waters. Results from water sampling in the Forsmark area, January-December 2009

    International Nuclear Information System (INIS)

    Nilsson, Ann-Chatrin; Borgiel, Micke; Qvarfordt, Susanne

    2010-09-01

    The fifth year (2009) of hydrochemical monitoring of groundwaters, surface waters and precipitation in Forsmark is documented in the report. The hydrochemical monitoring programme 2009 included water sampling from: - percussion- and core boreholes equipped with installations for long-term pressure monitoring, tracer tests and water sampling in packed off borehole sections, sampling and analysis performed twice (spring and autumn), - near surface groundwaters (sampling four times a year), - private wells (once per year in October), - surface waters (eleven sampling occasions per year). Due to the somewhat different performance of the hydrogeochemical monitoring of the deep groundwaters during the autumn 2009 compared to previous years, some new findings and knowledge were obtained: 1) Removal of water volumes corresponding to three to five times the volume of the borehole section (the routine procedure) is seldom enough to obtain a complete exchange of the water present in the borehole section when the pumping starts. 2) It is likely that the elevated sulphide concentrations observed in the monitoring programme /1/ is due to contamination from initial water present in the borehole sections when the pumping starts. This water may have a very high sulphide concentration. Dirty water in tubes and in stand pipes may also contribute to the enhanced sulphide concentration. 3) Plug flow calculations will be introduced in the future as a new routine procedure to estimate the water volumes to be removed, in order to exchange the section water volume, prior to groundwater sampling in delimited borehole sections. During the autumn sampling, sample series of five samples per sampling location were collected during continuous pumping in thirteen selected borehole sections. Furthermore, special efforts were put on cleaning of stand pipes and exchange of water prior to sampling. The analytical protocol was rather extensive and included sulphide and uranium analyses for each sample

  12. Investigation of Effect of High, Short Duration Temperatures on Fiber Graphitization and Resulting Property Changes in 3D Woven TPS Preforms During Entry Trajectories, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — To address the need for low-ballistic coefficient aeroshells with minimal impact on vehicle weight, NASA is investigating flexible thermal protection system (TPS)...

  13. Incidence of previously undetected disease in routine paediatric otolaryngology admissions.

    Science.gov (United States)

    Zeitoun, H; Robinson, P

    1996-06-01

    The process of clerking routine pre-operative admissions involves the house officer taking a full medical history and performing a full physical examination. The diagnostic yield is thought to be low, and the educational value to the house officer is also small. This study addresses the question as to whether routine physical examination is always indicated. One hundred and nine children admitted for routine Otolaryngology procedures were prospectively studied to identify the importance of examination in the pre-operative assessment of patients. The results showed that 51 per cent of the children admitted had risk factors. The medical history was sufficient to identify these risk factors in all patients with the exception of one cardiac condition. This study concludes that a suitable alternative to the current process of clerking such as a standardized nurse history could be safely and efficiently undertaken. Eliminating the tiny percentage of previously unrecognized disease would be a prerequisite for such a change.

  14. Determining root correspondence between previously and newly detected objects

    Science.gov (United States)

    Paglieroni, David W.; Beer, N Reginald

    2014-06-17

    A system that applies attribute and topology based change detection to networks of objects that were detected on previous scans of a structure, roadway, or area of interest. The attributes capture properties or characteristics of the previously detected objects, such as location, time of detection, size, elongation, orientation, etc. The topology of the network of previously detected objects is maintained in a constellation database that stores attributes of previously detected objects and implicitly captures the geometrical structure of the network. A change detection system detects change by comparing the attributes and topology of new objects detected on the latest scan to the constellation database of previously detected objects.

  15. Analysis of Product Buying Decision on Lazada E-commerce based on Previous Buyers’ Comments

    Directory of Open Access Journals (Sweden)

    Neil Aldrin

    2017-06-01

    Full Text Available The aims of the present research are: 1 to know that product buying decision possibly occurs, 2 to know how product buying decision occurs on Lazada e-commerce’s customers, 3 how previous buyers’ comments can increase product buying decision on Lazada e-commerce. This research utilizes qualitative research method. Qualitative research is a research that investigates other researches and makes assumption or discussion result so that other analysis results can be made in order to widen idea and opinion. Research result shows that product which has many ratings and reviews will trigger other buyers to purchase or get that product. The conclusion is that product buying decision may occur because there are some processes before making decision which are: looking for recognition and searching for problems, knowing the needs, collecting information, evaluating alternative, evaluating after buying. In those stages, buying decision on Lazada e-commerce is supported by price, promotion, service, and brand.

  16. How well suited are maar lakes of Madagascar for palaeoenvironmental multi-proxy reconstructions? - First results from shallow seismic, sedimentological and hydrological investigations in Central and Northwest Madagascar.

    Science.gov (United States)

    Daut, Gerhard; Jasmin Krahn, Kim; Rabhobisoa, Jean-Jacques; Ornella Moanazafy, Sergénie; Haberzettl, Torsten; Kasper, Thomas; Mäusbacher, Roland; Schwalb, Antje

    2017-04-01

    Madagascar is well known for its unique flora and fauna which are frequently in the focus of scientific investigations. However, studies on environmental changes in Madagascar linked to Quaternary climatic and/or anthropogenic impact are scarce. The aim of this initial study is to evaluate the potential of maar lakes, situated in different climatic zones of Madagascar, for paleoenvironmental studies and to identify promising coring sites with continuous sediment sequences reaching far back in time. Therefore, in November 2016, a shallow seismic profiling campaign, combined with surface sediment, short gravity core (max. 1.8 m), water and plankton sampling was performed on three target sites. These were two deep maar lakes, i.e., Andraikiba (Central Madagascar, 50m waterdepth) as well as Amparahibe (46,5m waterdepth) and Andampy Ambatoloaka, a shallow (5m waterdepth during low tide) former maar lake now connected to the Ocean (both NW-Madagascar. Vertical water parameter measurements in Lake Amparahibe confirm anoxic bottom conditions, while dissolved oxygen values at the water surface are about 7.9 mg/L (103%). Temperature decreases with depth from 29.3 °C to 27.2 °C, and the lake is slightly alkaline with an electrical conductivity of around 245 µS/cm. Since Andampy Ambatoloaka is connected to the ocean, it shows slightly alkaline conditions as well, electrical conductivity is high ( 57.8 mS/cm) and dissolved oxygen and temperature values are relatively stable at about 8.2 mg/L (104%) and 28.1 °C, respectively. The shallow seismic survey shows an infill with layered sediments of >50 m thickness in Lake Andraikiba. In Lake Amparahibe natural gas in the sediment prevented deeper penetration, however the record shows 10 m of undisturbed, layered sediments in the uppermost part. Sediment cores obtained from both lakes consist of dark brownish to blackish, clayey to silty and partly laminated sediments. High values of magnetic susceptibilities (>1800*10-6 SI) and

  17. Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

    DEFF Research Database (Denmark)

    Osorio, A; Milne, R L; Pita, G

    2009-01-01

    for BRCA1 (per-allele HR: 0.98, 95% CI: 0.93-1.04, P=0.5) or BRCA2 (per-allele HR: 0.97, 95% CI: 0.89-1.06, P=0.5) mutation carriers.Conclusion:This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out.British Journal of Cancer advance......Background:In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers.Methods:We have...... genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach.Results:We found no evidence of association with breast cancer risk...

  18. Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

    DEFF Research Database (Denmark)

    Osorio, A.; Milne, R.L.; Pita, G.

    2009-01-01

    BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers. METHODS: We have...... genotyped rs744154 in 9408 BRCA1 and 5632 BRCA2 mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and assessed its association with breast cancer risk using a retrospective weighted cohort approach. RESULTS: We found no evidence of association with breast cancer risk...... for BRCA1 (per-allele HR: 0.98, 95% CI: 0.93-1.04, P = 0.5) or BRCA2 (per-allele HR: 0.97, 95% CI: 0.89-1.06, P = 0.5) mutation carriers. CONCLUSION: This SNP is not a significant modifier of breast cancer risk for mutation carriers, though weak associations cannot be ruled out Udgivelsesdato: 2009/12/15...

  19. Motivational activities based on previous knowledge of students

    Science.gov (United States)

    García, J. A.; Gómez-Robledo, L.; Huertas, R.; Perales, F. J.

    2014-07-01

    Academic results depend strongly on the individual circumstances of students: background, motivation and aptitude. We think that academic activities conducted to increase motivation must be tuned to the special situation of the students. Main goal of this work is analyze the students in the first year of the Degree in Optics and Optometry in the University of Granada and the suitability of an activity designed for those students. Initial data were obtained from a survey inquiring about the reasons to choose this degree, their knowledge of it, and previous academic backgrounds. Results show that: 1) the group is quite heterogeneous, since students have very different background. 2) Reasons to choose the Degree in Optics and Optometry are also very different, and in many cases were selected as a second option. 3) Knowledge and motivations about the Degree are in general quite low. Trying to increase the motivation of the students we designed an academic activity in which we show different topics studied in the Degree. Results show that students that have been involved in this activity are the most motivated and most satisfied with their election of the degree.

  20. Analysis of 60 706 Exomes Questions the Role of De Novo Variants Previously Implicated in Cardiac Disease

    DEFF Research Database (Denmark)

    Paludan-Müller, Christian; Ahlberg, Gustav; Ghouse, Jonas

    2017-01-01

    sought to evaluate the pathogenicity of de novo variants previously associated with cardiac disease based on a large population-representative exome database. METHODS AND RESULTS: We performed a literature search for previous publications on de novo variants associated with severe arrhythmias...... and structural heart diseases and investigated whether these variants were present in the Exome Aggregation Consortium (ExAC) database (n=60 706). We identified monogenic variants in single case reports and smaller studies (≤200 subjects) and variants considered to increase susceptibility of disease in 3 larger...

  1. Aespoe HRL - Geoscientific evaluation 1997/4. Results from pre-investigation and detailed site characterization. Comparison of predictions and observations. Hydrogeology, groundwater chemistry and transport of solutes

    International Nuclear Information System (INIS)

    Rhen, I.; Gustafson, Gunnar; Wikberg, P.

    1997-06-01

    The pre-investigations for the Aespoe Hard Rock Laboratory were started in 1986 and involved extensive field measurements, aimed at characterizing the rock formations with regard to geology, hydrogeology, hydrochemistry and rock mechanics. Prior to the excavation in 1990 predictions were made for the excavation phase concerning: geology, ground water flow and chemistry, transport of solutes and mechanical stability. This report presents a comparison between these predictions and the observations made during the excavation. Also, investigation methods for the 700-2874 m sections of the tunnel are evaluated

  2. Medication abortion failure in women with and without previous cesarean delivery.

    Science.gov (United States)

    Dehlendorf, Christine E; Fox, Edith E; Ali, Rose F; Anderson, Nora C; Reed, Reiley D; Lichtenberg, E Steve

    2015-11-01

    To investigate the association between previous cesarean delivery and medication abortion failure and the association between parity and failure. Data were abstracted from 2035 consecutive charts of women who underwent medication abortion in 2011. All women were at 63 days gestation or less and received mifepristone 200mg orally and misoprostol 800 mcg buccally. We used multivariate logistic regression to assess the relationship between failure, defined as requiring either curettage or additional medication, and prior cesarean delivery. We also examined the relationship between failure and parity. Follow-up was available on 1609 (79%) patients. Overall, 4.5% of patients experienced failure. Neither cesarean delivery nor parity was associated with failure; 6.5% of women with prior cesarean delivery experienced failure, compared to 3.7% of nulliparous women [adjusted odds ratio (aOR), 1.79, 95% confidence interval (CI), 0.83-3.87]. With regard to parity, 4.7% of women with two or more previous births experienced failure, compared to 3.7% of nulliparous women (aOR, 1.07, 95% CI, 0.54-2.14). We did not find significant associations between prior cesarean delivery and failure or parity and failure. A previous study of patients who had received a less effective regimen reported significant associations between cesarean delivery and failure and parity and failure. While our results do not rule out the possibility of modest associations due to our limited statistical power, they are reassuring relative to previous findings. Our results suggest that if there are differences in women's odds of medication abortion failure by obstetric history, such differences are unlikely to be large. Providers and patients may factor this information into decision making about methods of pregnancy termination. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Surgical treatment of breast cancer in previously augmented patients.

    Science.gov (United States)

    Karanas, Yvonne L; Leong, Darren S; Da Lio, Andrew; Waldron, Kathleen; Watson, James P; Chang, Helena; Shaw, William W

    2003-03-01

    The incidence of breast cancer is increasing each year. Concomitantly, cosmetic breast augmentation has become the second most often performed cosmetic surgical procedure. As the augmented patient population ages, an increasing number of breast cancer cases among previously augmented women can be anticipated. The surgical treatment of these patients is controversial, with several questions remaining unanswered. Is breast conservation therapy feasible in this patient population and can these patients retain their implants? A retrospective review of all breast cancer patients with a history of previous augmentation mammaplasty who were treated at the Revlon/UCLA Breast Center between 1991 and 2001 was performed. During the study period, 58 patients were treated. Thirty patients (52 percent) were treated with a modified radical mastectomy with implant removal. Twenty-eight patients (48 percent) underwent breast conservation therapy, which consisted of lumpectomy, axillary lymph node dissection, and radiotherapy. Twenty-two of the patients who underwent breast conservation therapy initially retained their implants. Eleven of those 22 patients (50 percent) ultimately required completion mastectomies with implant removal because of implant complications (two patients), local recurrences (five patients), or the inability to obtain negative margins (four patients). Nine additional patients experienced complications resulting from their implants, including contracture, erosion, pain, and rupture. The data illustrate that breast conservation therapy with maintenance of the implant is not ideal for the majority of augmented patients. Breast conservation therapy with explantation and mastopexy might be appropriate for rare patients with large volumes of native breast tissue. Mastectomy with immediate reconstruction might be a more suitable choice for these patients.

  4. Bridge-in-a-backpack(TM) : task 3.2: investigating soil - structure interaction - modeling and experimental results of steel arches.

    Science.gov (United States)

    2015-07-01

    This report includes fulfillment of Task 3.2 of a multi-task contract to further enhance concrete filled FRP tubes, or : the Bridge in a Backpack. Task 3 is an investigation of soil-structure interaction for the FRP tubes. Task 3.2 is the : modeling ...

  5. Bridge-in-a-backpack(TM) task 3.3 : investigate soil-structure interaction-modeling and experimental results of concrete filled FRP tube arches.

    Science.gov (United States)

    2015-12-01

    This report includes fulfillment of Task 3.3 of a multi-task contract to further enhance concrete filled FRP tubes, or : the Bridge in a Backpack. Task 3 is an investigation of soil-structure interaction for the FRP tubes. Task 3.3 is the : modeling ...

  6. Iodine intake before and after mandatory iodization in Denmark: results from the Danish Investigation of Iodine Intake and Thyroid Diseases (DanThyr) study

    DEFF Research Database (Denmark)

    Rasmussen, Lone Banke; Carle, Allan; Jørgensen, Torben Walther

    2008-01-01

    Iodine deficiency is still common in some European countries. In Denmark an iodine fortification programme was introduced in 1998 and a monitoring programme was established prior to iodization. This study reports the change in urinary iodine excretion caused by fortification and investigates dete...

  7. Sleep quality and duration in relation to memory in the elderly: Initial results from the Hellenic Longitudinal Investigation of Aging and Diet.

    Science.gov (United States)

    Tsapanou, A; Gu, Y; O'Shea, D M; Yannakoulia, M; Kosmidis, M; Dardiotis, E; Hadjigeorgiou, G; Sakka, P; Stern, Y; Scarmeas, N

    2017-05-01

    Sleep is crucial for cognition, particularly for memory, given its complex association with neurodegenerative processes. The aim of the present study was to examine the association between sleep quality as well as sleep duration and memory performance in a Greek elderly population. Cross-sectional design in the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD), a population representative study of Greek elderly (65years or older). Data from 1589 participants free of sleep medication were included. Sleep quality was estimated by using the Sleep Scale from the Medical Outcomes Study. An extensive neuropsychological assessment examining memory was administered to each participant. Linear regression analyses were used to examine whether sleep quality (higher score, poor quality) and/or sleep duration were associated with memory expressed in the form of a z-score. Age, sex, education, and body mass index were included as covariates. The main analyses were conducted first on the total sample, then with the exclusion of demented participants, and finally with the exclusion of both demented and participants with Mild Cognitive Impairment (MCI). We then conducted further analyses on the non-demented, non-MCI group, initially stratified by Apolipoprotein E-ε4 gene. We further examined the role of co-morbidities, as well as the association between sleep duration groups and memory. We also explored any interaction effect between sex and sleep quality/duration on memory. We then examined the associations between components of sleep measures and memory scores. Lastly, we examined the associations between sleep quality/duration and verbal/non-verbal memory separately. In the total sample, we noted significant associations between sleep duration and memory (B=-0.001, p≤0.0001), but not for sleep quality and memory (B=-0.038, p=0.121). After excluding the demented participants, the associations were significant for: sleep quality and memory (B=-0.054, p=0.023), and

  8. Influence of Previous Knowledge in Torrance Tests of Creative Thinking

    Directory of Open Access Journals (Sweden)

    María Aranguren

    2015-07-01

    Full Text Available The aim of this work is to analyze the influence of study field, expertise and recreational activities participation in Torrance Tests of Creative Thinking (TTCT, 1974 performance. Several hypotheses were postulated to explore the possible effects of previous knowledge in TTCT verbal and TTCT figural university students’ outcomes. Participants in this study included 418 students from five study fields: Psychology;Philosophy and Literature, Music; Engineering; and Journalism and Advertising (Communication Sciences. Results found in this research seem to indicate that there in none influence of the study field, expertise and recreational activities participation in neither of the TTCT tests. Instead, the findings seem to suggest some kind of interaction between certain skills needed to succeed in specific studies fields and performance on creativity tests, such as the TTCT. These results imply that TTCT is a useful and valid instrument to measure creativity and that some cognitive process involved in innovative thinking can be promoted using different intervention programs in schools and universities regardless the students study field.

  9. [Subjective Aspects of Return to Work and Social Reintegration in Patients with Extensive Work-related Problems in Cardiac Rehabilitation - Results of a Qualitative Investigation].

    Science.gov (United States)

    Schulz-Behrendt, C; Salzwedel, A; Rabe, S; Ortmann, K; Völler, H

    2017-06-01

    This study investigated subjective biopsychosocial effects of coronary heart disease (CHD), coping strategies and social support in patients undergoing cardiac rehabilitation (CR) and having extensive work-related problems. A qualitative investigation was performed in 17 patients (48.9±7.0 y, 13 male) with extensive work-related problems (SIMBO-C>30). All patients were interviewed with structured surveys. Data analysis was performed using a software that is based on the content analysis approach of Mayring. In regard to effects of disease, patients indicated social aspects including occupational aspects (62%) more often than physical or mental factors (9 or 29%). Applied coping strategies and support services are mainly focused on physical impairments (70 or 45%). The development of appropriate coping strategies was insufficient although social effects of disease were subjectively meaningful for patients in CR. © Georg Thieme Verlag KG Stuttgart · New York.

  10. Detection of ruthenium 106 in France and in Europe. Results of IRSN's investigations. Information report (Update of report of 09/10/2017)

    International Nuclear Information System (INIS)

    2017-01-01

    Ruthenium 106 has been detected in late September by several European networks involved in the monitoring of atmospheric radioactive contamination, at levels of a few milli-Becquerels per cubic meter of air. IRSN's investigations make it possible to provide information on the possible location of the source of the release as well as the order of magnitude of the quantities released

  11. An investigation into the functional outcomes of individuals with paraplegia, resulting from spinal cord injury, following discharge from a rehabilitation setting

    LENUS (Irish Health Repository)

    McNamara, Angela Dr.

    2005-01-01

    The purpose of this study was to investigate if changes occurred in the functional independence of spinal cord injured (SCI) patients, following discharge from a rehabilitation setting. The research was carried out on patients with a paraplegic injury, who underwent rehabilitation in the spinal injury unit of a Dublin based rehabilitation hospital. Eight male subjects residing in the Republic of Ireland were recruited to the study between October 2004 and May 2005.\\r\

  12. Recent results of the investigation of a micro-fluidic sampling chip and sampling system for hot cell aqueous processing streams

    Energy Technology Data Exchange (ETDEWEB)

    Tripp, J.; Smith, T.; Law, J. [Idaho National Laboratory: P.O. Box 1625, Idaho Falls, ID 83415 (United States)

    2013-07-01

    A Fuel Cycle Research and Development project has investigated an innovative sampling method that could evolve into the next generation sampling and analysis system for metallic elements present in aqueous processing streams. Initially sampling technologies were evaluated and micro-fluidic sampling chip technology was selected and tested. A conceptual design for a fully automated microcapillary-based system was completed and a robotic automated sampling system was fabricated. The mechanical and sampling operation of the completed sampling system was investigated. Different sampling volumes have been tested. It appears that the 10 μl volume has produced data that had much smaller relative standard deviations than the 2 μl volume. In addition, the production of a less expensive, mass produced sampling chip was investigated to avoid chip reuse thus increasing sampling reproducibility/accuracy. The micro-fluidic-based robotic sampling system's mechanical elements were tested to ensure analytical reproducibility and the optimum robotic handling of micro-fluidic sampling chips. (authors)

  13. Five-year clinical results of cervical total disc replacement compared with anterior discectomy and fusion for treatment of 2-level symptomatic degenerative disc disease: a prospective, randomized, controlled, multicenter investigational device exemption clinical trial.

    Science.gov (United States)

    Radcliff, Kris; Coric, Domagoj; Albert, Todd

    2016-08-01

    OBJECTIVE The purpose of this study was to report the outcome of a study of 2-level cervical total disc replacement (Mobi-C) versus anterior cervical discectomy and fusion (ACDF). Although the long-term outcome of single-level disc replacement has been extensively described, there have not been previous reports of the 5-year outcome of 2-level cervical disc replacement. METHODS This study reports the 5-year results of a prospective, randomized US FDA investigational device exemption (IDE) study conducted at 24 centers in patients with 2-level, contiguous, cervical spondylosis. Clinical outcomes at up to 60 months were evaluated, including validated outcome measures, incidence of reoperation, and adverse events. The complete study data and methodology were critically reviewed by 3 independent surgeon authors without affiliation with the IDE study or financial or institutional bias toward the study sponsor. RESULTS A total of 225 patients received the Mobi-C cervical total disc replacement device and 105 patients received ACDF. The Mobi-C and ACDF follow-up rates were 90.7% and 86.7%, respectively (p = 0.39), at 60 months. There was significant improvement in all outcome scores relative to baseline at all time points. The Mobi-C patients had significantly more improvement than ACDF patients in terms of Neck Disability Index score, SF-12 Physical Component Summary, and overall satisfaction with treatment at 60 months. The reoperation rate was significantly lower with Mobi-C (4%) versus ACDF (16%). There were no significant differences in the adverse event rate between groups. CONCLUSIONS Both cervical total disc replacement and ACDF significantly improved general and disease-specific measures compared with baseline. However, there was significantly greater improvement in general and disease-specific outcome measures and a lower rate of reoperation in the 2-level disc replacement patients versus ACDF control patients. Clinical trial registration no. NCT00389597

  14. 2 CFR 1.215 - Relationship to previous issuances.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Relationship to previous issuances. 1.215 Section 1.215 Grants and Agreements ABOUT TITLE 2 OF THE CODE OF FEDERAL REGULATIONS AND SUBTITLE A Introduction toSubtitle A § 1.215 Relationship to previous issuances. Although some of the guidance was...

  15. 2 CFR 230.45 - Relationship to previous issuance.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Relationship to previous issuance. 230.45 Section 230.45 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR NON-PROFIT ORGANIZATIONS (OMB CIRCULAR A-122) § 230.45 Relationship to previous issuance. (a...

  16. Research Note Effects of previous cultivation on regeneration of ...

    African Journals Online (AJOL)

    Research Note Effects of previous cultivation on regeneration of Julbernadia globiflora and Brachystegia spiciformis in grazing areas of Mupfurudzi ... Plant attributes for Julbernadia globiflora and Brachystegia spiciformis were measured in previously cultivated and uncultivated sites making up rangelands of the scheme.

  17. 49 CFR 173.23 - Previously authorized packaging.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Previously authorized packaging. 173.23 Section... REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Preparation of Hazardous Materials for Transportation § 173.23 Previously authorized packaging. (a) When the regulations specify a packaging with a specification marking...

  18. 75 FR 76056 - FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT:

    Science.gov (United States)

    2010-12-07

    ... SECURITIES AND EXCHANGE COMMISSION Sunshine Act Meeting FEDERAL REGISTER CITATION OF PREVIOUS ANNOUNCEMENT: STATUS: Closed meeting. PLACE: 100 F Street, NE., Washington, DC. DATE AND TIME OF PREVIOUSLY ANNOUNCED MEETING: Thursday, December 9, 2010 at 2 p.m. CHANGE IN THE MEETING: Time change. The closed...

  19. Triple outlet right ventricle: a previously unknown cardiac malformation.

    Science.gov (United States)

    Tingo, Jennifer E; Carroll, Sheila J; Crystal, Matthew A

    2015-03-01

    We present the case of an infant with three distinct outflow tracts from the right ventricle. Three outlets from the heart have been previously named the "Tritruncal Heart". We review the two previously reported cases of tritruncal hearts and describe the anatomy, diagnosis, surgical management, and outcome of our case. Embryologic implications are also discussed.

  20. The prevalence of previous self-harm amongst self-poisoning patients in Sri Lanka

    DEFF Research Database (Denmark)

    Mohamed, Fahim; Perera, Aravinda; Wijayaweera, Kusal

    2011-01-01

    was to investigate the prevalence of previous self-harm among a consecutive series of self-harm patients presenting to hospitals in rural Sri Lanka. METHOD: Six hundred and ninety-eight self-poisoning patients presenting to medical wards at two hospitals in Sri Lanka were interviewed about their previous episodes...... with previous Asian research and is considerably lower than that seen in the West. Explanations for these low levels of repeat self-harm require investigation. Our data indicate that a focus on the aftercare of those who attempt suicide in Sri Lanka may have a smaller impact on suicide incidence than may...

  1. The role of substance use and emotion dysregulation in predicting risk for incapacitated sexual revictimization in women: results of a prospective investigation.

    Science.gov (United States)

    Messman-Moore, Terri L; Ward, Rose Marie; Zerubavel, Noga

    2013-03-01

    Incapacitated sexual assault (ISA) is the most common form of sexual victimization experienced by college women. Although ISA victims are at risk for future assaults, few studies have examined mechanisms responsible for ISA revictimization besides heavy drinking. Using a prospective design, the present study examined whether emotion dysregulation, given its association with interpersonal trauma and substance use, increases risk for revictimization among women with a history of ISA above and beyond the effects of substance use. Female college students (n = 229) completed a baseline assessment followed by assessment of incapacitated sexual assault over a 9-week follow-up period. Approximately 36% of participants reported a history of ISA, and 73% of those victimized during the study had a history of ISA. Revictimized women reported higher levels of alcohol-related problems, greater marijuana use, greater emotion dysregulation, and higher levels of fear and guilt prior to experiencing ISA during the study; however, they did not consume more alcohol than previously victimized women. In a logistic regression analysis, guilt, emotion dysregulation, and marijuana use accurately classified 78.9% of ISA revictimized women. Women with a history of ISA are at substantial risk for ISA revictimization. Findings suggest that even very small increases in emotion dysregulation, particularly in impulsivity, as well as marijuana use, impact revictimization risk substantially. Efficacy of interventions to reduce ISA revictimization may be improved if emotion dysregulation is addressed. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  2. CHEERS Results from NGC 3393. II. Investigating the Extended Narrow-line Region Using Deep Chandra Observations and Hubble Space Telescope Narrow-line Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Maksym, W. Peter; Fabbiano, Giuseppina; Elvis, Martin; Karovska, Margarita; Paggi, Alessandro; Raymond, John [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Wang, Junfeng [Department of Astronomy, Physics Building, Xiamen University Xiamen, Fujian, 361005 (China); Storchi-Bergmann, Thaisa, E-mail: walter.maksym@cfa.harvard.edu [Departamento de Astronomia, Universidade Federal do Rio Grande do Sul, IF, CP 15051, 91501-970 Porto Alegre, RS (Brazil)

    2017-07-20

    The CHandra Extended Emission Line Region Survey (CHEERS) is an X-ray study of nearby active galactic nuclei (AGNs) designed to take full advantage of Chandra 's unique angular resolution by spatially resolving feedback signatures and effects. In the second paper of a series on CHEERS target NGC 3393, we examine deep high-resolution Chandra images and compare them with Hubble Space Telescope narrow-line images of [O iii], [S ii], and H α , as well as previously unpublished mid-ultraviolet (MUV) images. The X-rays provide unprecedented evidence that the S-shaped arms that envelope the nuclear radio outflows extend only ≲0.″2 (≲50 pc) across. The high-resolution multiwavelength data suggest that the extended narrow-line region is a complex multiphase structure in the circumnuclear interstellar medium (ISM). Its ionization structure is highly stratified with respect to outflow-driven bubbles in the bicone and varies dramatically on scales of ∼10 pc. Multiple findings show likely contributions from shocks to the feedback in regions where radio outflows from the AGN most directly influence the ISM. These findings include H α evidence for gas compression and extended MUV emission and are in agreement with existing STIS kinematics. Extended filamentary structure in the X-rays and optical suggests the presence of an undetected plasma component, whose existence could be tested with deeper radio observations.

  3. No discrimination against previous mates in a sexually cannibalistic spider

    Science.gov (United States)

    Fromhage, Lutz; Schneider, Jutta M.

    2005-09-01

    In several animal species, females discriminate against previous mates in subsequent mating decisions, increasing the potential for multiple paternity. In spiders, female choice may take the form of selective sexual cannibalism, which has been shown to bias paternity in favor of particular males. If cannibalistic attacks function to restrict a male's paternity, females may have little interest to remate with males having survived such an attack. We therefore studied the possibility of female discrimination against previous mates in sexually cannibalistic Argiope bruennichi, where females almost always attack their mate at the onset of copulation. We compared mating latency and copulation duration of males having experienced a previous copulation either with the same or with a different female, but found no evidence for discrimination against previous mates. However, males copulated significantly shorter when inserting into a used, compared to a previously unused, genital pore of the female.

  4. Retrospective analysis on malignant calcification previously misdiagnosed as benign on screening mammography

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Su Min [Dept. of Radiology, Research Institute of Radiology, Chung Ang University Hospital, Seoul(Korea, Republic of); Cha, Joo Hee; Kim, Hak Hee; Shin, Hee Jung; Chae, Eun Young; Choi, Woo Jung [Dept. of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2017-04-15

    The purpose of our study was to investigate the morphology and distribution of calcifications initially interpreted as benign or probably benign, but proven to be malignant by subsequent stereotactic biopsy, and to identify the reason for misinterpretation or underestimation at the initial diagnosis. Out of 567 women who underwent stereotactic biopsy for calcifications at our hospital between January 2012 and December 2014, 167 women were diagnosed with malignancy. Forty-six of these 167 women had previous mammography assessed as benign or probably benign which was changed to suspicious malignancy on follow-up mammography. Of these 46 women, three women with biopsy-proven benign calcifications at the site of subsequent cancer were excluded, and 43 patients were finally included. The calcifications (morphology, distribution, extent, associated findings) in the previous and follow-up mammography examinations were analyzed according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon and assessment category. We classified the patients into two groups: 1) group A patients who were still retrospectively re-categorized as less than or equal to BI-RADS 3 and 2) group B patients who were re-categorized as equal to or higher than BI-RADS 4a and whose results should have prompted previous diagnostic assessment. In the follow-up mammography examinations, change in calcification morphology (n = 27, 63%) was the most frequent cause of assessment change. The most frequent previous mammographic findings of malignant calcification were amorphous morphology (n = 26, 60%) and grouped distribution (n = 36, 84%). The most frequent calcification findings at reassessment were amorphous morphology (n = 4, 9%), fine pleomorphic calcification (n = 30, 70%), grouped distribution (n = 23, 53%), and segmental calcification (n = 12, 28%). There were 33 (77%) patients in group A, and 10 patients (23%) in group B. Amorphous morphology and grouped distribution were the most frequent

  5. Radon in the water from drilled wells. Results from an investigation in Oerebro; Radon i vatten fraan bergborrade brunnar. Resultat fraan en undersoekning i oerebro kommun

    Energy Technology Data Exchange (ETDEWEB)

    Liden, E.; Andersson, Lennart [Regionsjukhuset, Oerebro (Sweden). Yrkes- och miljoemedicinska kliniken; Linden, A. [Svensk Geofysik AB, Falun (Sweden); Aakerblom, G. [Statens Straalskyddsinstitut, Stockholm (Sweden); Aakesson, T. [Miljoe- och haelsoskyddsfoervaltningen, Oerebro (Sweden)

    1995-09-01

    In 1991 a drilled well containing water with a radon count of about 20,000 Bq/l was found in the city of Oerebro in southern Sweden. A study was started to develop measures to decrease the radon content of water, investigate public health risks and determine the prevalence of high-radon waters in Sweden. 1991-94 various techniques were tested to reduce the concentration of radon in water. The efficiency of aerating high-radon drinking water was studied under field conditions using two modified aerators in a well, in a pressure tank, and in a column of pellets. The efficiency varied from 20 to 99%. A survey of radon in water from 269 drilled wells was conducted in the Municipality of Oerebro. In water from 78 wells, the mean concentration of radon was 1336 Bq/l. The emanation of radon during normal household activities was studied in a home supplied with water from a drilled well whose radon count was approx 20,000 Bq/l. A geological investigation revealed the presence of thin Uranium-loaded fissures in the bedrock (granite) surrounding the well. 130 refs, 16 figs, 14 tabs.

  6. Weather, day length and physical activity in older adults: Cross-sectional results from the European Prospective Investigation into Cancer and Nutrition (EPIC Norfolk Cohort.

    Directory of Open Access Journals (Sweden)

    Yu-Tzu Wu

    Full Text Available A wide range of environmental factors have been related to active ageing, but few studies have explored the impact of weather and day length on physical activity in older adults. We investigate the cross-sectional association between weather conditions, day length and activity in older adults using a population-based cohort in England, the European Prospective Investigation into Cancer and Nutrition (EPIC Norfolk study.Physical activity was measured objectively over 7 days using an accelerometer and this was used to calculate daily total physical activity (counts per minute, daily minutes of sedentary behaviour and light, moderate and vigorous physical activity (LMVPA. Day length and two types of weather conditions, precipitation and temperature, were obtained from a local weather station. The association between these variables and physical activity was examined by multilevel first-order autoregressive modelling.After adjusting for individual factors, short day length and poor weather conditions, including high precipitation and low temperatures, were associated with up to 10% lower average physical activity (p<0.01 and 8 minutes less time spent in LMVPA but 15 minutes more sedentary time, compared to the best conditions.Day length and weather conditions appear to be an important factor related to active ageing. Future work should focus on developing potential interventions to reduce their impact on physical activity behaviours in older adults.

  7. New Strategies for Cultivation and Detection of Previously Uncultured Microbes

    Science.gov (United States)

    Stevenson, Bradley S.; Eichorst, Stephanie A.; Wertz, John T.; Schmidt, Thomas M.; Breznak, John A.

    2004-01-01

    An integrative approach was used to obtain pure cultures of previously uncultivated members of the divisions Acidobacteria and Verrucomicrobia from agricultural soil and from the guts of wood-feeding termites. Some elements of the cultivation procedure included the following: the use of agar media with little or no added nutrients; relatively long periods of incubation (more than 30 days); protection of cells from exogenous peroxides; and inclusion of humic acids or a humic acid analogue (anthraquinone disulfonate) and quorum-signaling compounds (acyl homoserine lactones) in growth media. The bacteria were incubated in the presence of air and in hypoxic (1 to 2% O2 [vol/vol]) and anoxic atmospheres. Some bacteria were incubated with elevated concentrations of CO2 (5% [vol/vol]). Significantly more Acidobacteria were found on isolation plates that had been incubated with 5% CO2. A simple, high-throughput, PCR-based surveillance method (plate wash PCR) was developed. This method greatly facilitated detection and ultimate isolation of target bacteria from as many as 1,000 colonies of nontarget microbes growing on the same agar plates. Results illustrate the power of integrating culture methods with molecular techniques to isolate bacteria from phylogenetic groups underrepresented in culture. PMID:15294811

  8. Measles Outbreak among Previously Immunized Adult Healthcare Workers, China, 2015

    Directory of Open Access Journals (Sweden)

    Zhengyi Zhang

    2016-01-01

    Full Text Available Measles is caused by measles virus belonging to genus Morbillivirus of the family Paramyxoviridae. Vaccination has played a critical role in controlling measles infection worldwide. However, in the recent years, outbreaks of measles infection still occur in many developing countries. Here, we report an outbreak of measles among healthcare workers and among the 60 measles infected patients 50 were healthcare workers including doctors, nurses, staff, and medics. Fifty-one patients (85% tested positive for IgM antibodies against the measles virus and 50 patients (83.3% tested positive for measles virus RNA. Surprisingly, 73.3% of the infected individuals had been previously immunized against measles. Since there is no infection division in our hospital, the fever clinics are located in the Emergency Division. In addition, the fever and rash were not recognized as measles symptoms at the beginning of the outbreak. These factors result in delay in isolation and early confirmation of the suspected patients and eventually a measles outbreak in the hospital. Our report highlights the importance of following a two-dose measles vaccine program in people including the healthcare workers. In addition, vigilant attention should be paid to medical staff with clinical fever and rash symptoms to avoid a possible nosocomial transmission of measles infection.

  9. Multispecies Coevolution Particle Swarm Optimization Based on Previous Search History

    Directory of Open Access Journals (Sweden)

    Danping Wang

    2017-01-01

    Full Text Available A hybrid coevolution particle swarm optimization algorithm with dynamic multispecies strategy based on K-means clustering and nonrevisit strategy based on Binary Space Partitioning fitness tree (called MCPSO-PSH is proposed. Previous search history memorized into the Binary Space Partitioning fitness tree can effectively restrain the individuals’ revisit phenomenon. The whole population is partitioned into several subspecies and cooperative coevolution is realized by an information communication mechanism between subspecies, which can enhance the global search ability of particles and avoid premature convergence to local optimum. To demonstrate the power of the method, comparisons between the proposed algorithm and state-of-the-art algorithms are grouped into two categories: 10 basic benchmark functions (10-dimensional and 30-dimensional, 10 CEC2005 benchmark functions (30-dimensional, and a real-world problem (multilevel image segmentation problems. Experimental results show that MCPSO-PSH displays a competitive performance compared to the other swarm-based or evolutionary algorithms in terms of solution accuracy and statistical tests.

  10. Coronary collateral vessels in patients with previous myocardial infarction

    International Nuclear Information System (INIS)

    Nakatsuka, M.; Matsuda, Y.; Ozaki, M.

    1987-01-01

    To assess the degree of collateral vessels after myocardial infarction, coronary angiograms, left ventriculograms, and exercise thallium-201 myocardial scintigrams of 36 patients with previous myocardial infarction were reviewed. All 36 patients had total occlusion of infarct-related coronary artery and no more than 70% stenosis in other coronary arteries. In 19 of 36 patients with transient reduction of thallium-201 uptake in the infarcted area during exercise (Group A), good collaterals were observed in 10 patients, intermediate collaterals in 7 patients, and poor collaterals in 2 patients. In 17 of 36 patients without transient reduction of thallium-201 uptake in the infarcted area during exercise (Group B), good collaterals were seen in 2 patients, intermediate collaterals in 7 patients, and poor collaterals in 8 patients (p less than 0.025). Left ventricular contractions in the infarcted area were normal or hypokinetic in 10 patients and akinetic or dyskinetic in 9 patients in Group A. In Group B, 1 patient had hypokinetic contraction and 16 patients had akinetic or dyskinetic contraction (p less than 0.005). Thus, patients with transient reduction of thallium-201 uptake in the infarcted area during exercise had well developed collaterals and preserved left ventricular contraction, compared to those in patients without transient reduction of thallium-201 uptake in the infarcted area during exercise. These results suggest that the presence of viable myocardium in the infarcted area might be related to the degree of collateral vessels

  11. Risky sexual behaviour in context: qualitative results from an investigation into risk factors for seroconversion among gay men who test for HIV.

    Science.gov (United States)

    Elam, G; Macdonald, N; Hickson, F C I; Imrie, J; Power, R; McGarrigle, C A; Fenton, K A; Gilbart, V L; Ward, H; Evans, B G

    2008-11-01

    The INSIGHT case-control study confirmed that HIV serodiscordant unprotected anal intercourse (SdUAI) remains the primary risk factor for HIV infection in gay men in England. This paper uses qualitative follow-up data to examine the contexts of SdUAI and other risk factors among the case-control study participants. In-depth interviews were conducted with 26 recent HIV seroconverters and 22 non-converters. Purposive selection was used to provide diversity in demographics and sexual behaviour and to facilitate exploration of risk factors identified in the case-control study. Condoms were perceived as barriers to intimacy, trust and spontaneity. The potential consequences of the loss of these were traded off against the consequences of HIV infection. Previous negative HIV tests and the adoption of risk reduction strategies diminished the perceived threat of HIV infection, supporting beliefs that HIV was something that happened to others. Depression and low self-esteem, often combined with use of alcohol or other drugs, led to further risk taking and loss of control over risk reduction strategies. A range of psychosocial reasons led some men to engage in UAI with serodiscordant or unknown partners, despite high levels of risk awareness. Men in their mid-life, those in serodiscordant relationships and men that had experienced bereavement or other significant, negative, life events revealed factors related to these circumstances that contributed to increases in risky UAI. A diverse portfolio of interventions is required to build confidence and control over safer sex practices that are responsive to gay men's wider emotional needs.

  12. An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

    Science.gov (United States)

    2015-06-01

    filling, be it steady or episodic, evokes a limited mass-reflex of the abdominal musculature . This contraction of abdominal muscle then stimulates the... activity in general ( abdominal wall and pelvic floor). Figure 7 illustrates these preliminary results. 0 20 40 60 Bladder Contraction Amplitude (BCA...over the course of the past year have been that NVC in chronic SCI are accompanied by intra- abdominal pressure increases resulting from abdominal wall

  13. A piloted simulator investigation of stability and control, display and crew-loading requirements for helicopter instrument approach. Part 1: Technical discussion and results

    Science.gov (United States)

    Lebacqz, J. V.; Forrest, R. D.; Gerdes, R. M.

    1982-01-01

    A ground-simulation experiment was conducted to investigate the influence and interaction of flight-control system, fight-director display, and crew-loading situation on helicopter flying qualities during terminal area operations in instrument conditions. The experiment was conducted on the Flight Simulator for Advanced Aircraft at Ames Research Center. Six levels of control complexity, ranging from angular rate damping to velocity augmented longitudinal and vertical axes, were implemented on a representative helicopter model. The six levels of augmentation were examined with display variations consisting of raw elevation and azimuth data only, and of raw data plus one-, two-, and three-cue flight directors. Crew-loading situations simulated for the control-display combinations were dual-pilot operation (representative auxiliary tasks of navigation, communications, and decision-making). Four pilots performed a total of 150 evaluations of combinations of these parameters for a representative microwave landing system (MLS) approach task.

  14. Preliminary Results of Altitude-Wind-Tunnel Investigation of X24C-4B Turbojet Engine. IV - Performance of Modified Compressor. Part 4; Performance of Modified Compressor

    Science.gov (United States)

    Thorman, H. Carl; Dupree, David T.

    1947-01-01

    The performance of the 11-stage axial-flow compressor, modified to improve the compressor-outlet velocity, in a revised X24C-4B turbojet engine is presented and compared with the performance of the compressor in the original engine. Performance data were obtained from an investigation of the revised engine in the MACA Cleveland altitude wind tunnel. Compressor performance data were obtained for engine operation with four exhaust nozzles of different outlet area at simulated altitudes from 15,OOO to 45,000 feet, simulated flight Mach numbers from 0.24 to 1.07, and engine speeds from 4000 to 12,500 rpm. The data cover a range of corrected engine speeds from 4100 to 13,500 rpm, which correspond to compressor Mach numbers from 0.30 to 1.00.

  15. Tracking and incentivizing substance abusers in longitudinal research: results of a survey of National Institute on Drug Abuse-funded investigators.

    Science.gov (United States)

    Farabee, David; Hawken, Angela; Griffith, Peter

    2011-06-01

    Increased recognition that addictive behaviors tend to be chronic and relapsing has led to a growing emphasis on longitudinal substance abuse research. The purpose of this study was to identify effective follow-up strategies used by National Institute on Drug Abuse-funded investigators who have conducted at least 1 study involving follow-up data collection from human subjects. A web-based survey was administered to a representative sample of National Institute on Drug Abuse-funded researchers (N = 153) with a history of conducting longitudinal research. Reported study response rates were generally high, although 27% of the studies fell below the 80% benchmark. Face-to-face and telephone-based interviews commanded the largest subject payments-2 to 3 times higher than compensation rates for collection of biologic samples. With regard to the presumed impact of low follow-up rates on the generalizability of study findings, one-third of investigators who compared baseline characteristics of those who did and did not participate in the follow-up found meaningful differences. Support was found for the hypothesis that follow-up rates and total compensation would be positively related, with the mean compensation amounts between studies achieving effect in the predicted direction. The majority of respondents reported difficulty in tracking and locating subjects, and study respondents often proved to be quite different from nonrespondents. Incentives improved follow-up rates to a point, although the relationship was not linear. Efforts to improve follow-up rates may be better spent on addressing tracking and locating logistics rather than on strategies to compel participation once the subject has been located.

  16. Adolescents previously involved in Satanism experiencing mental health problems

    Directory of Open Access Journals (Sweden)

    H Heathcote

    1999-09-01

    Full Text Available No research has previously been done regarding the phenomenon of adolescents who have previously been involved in Satanism and who experience obstacles in their strive for mental health. Adolescents previously involved in Satanism present behavioral problems like aggressive outbursts, depression, “ psychosis” or suicide attempts, that could lead to suicide. In the phenomenonanalysis semi-structured, phenomenological interviews were performed with the respondents and their parents. The respondents were requested to write a naïve sketch about their life. After completion of the data-control, guidelines for nursing staff were set.

  17. Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors?

    DEFF Research Database (Denmark)

    Gade, Malene R; Goukasian, Irina; Panduro, Nathalie

    2018-01-01

    Objective To estimate the prevalence of vaginal symptoms in postmenopausal women with breast cancer exposed to aromatase inhibitors, and to investigate if the risk of vaginal symptoms is associated with previous episodes of bacterial vaginosis. Methods Patients from Rigshospitalet and Herlev...... University Hospital, Denmark, were identified through the register of Danish Breast Cancer Cooperation Group and 78 patients participated in the study. Semiquantitave questionnaires and telephone interview were used to assess the prevalence of vaginal symptoms and previous episode(s) of bacterial vaginosis....... Multivariable logistic regression models were used to assess the association between vaginal symptoms and previous episodes of bacterial vaginosis. Results Moderate to severe symptoms due to vaginal itching/irritation were experienced by 6.4% (95% CI: 2.8-14.1%), vaginal dryness by 28.4% (95% CI: 19...

  18. Results of the investigation on validity of Japanese seismic design guidelines of nuclear facilities, based on the 1995 Hyogoken-Nanbu Earthquake

    International Nuclear Information System (INIS)

    Watabe, Makoto

    1997-01-01

    This paper describes the reviewed results and main discussions on some items thought to be problems in the 'Examination Guide for Aseismatic Design of the Nuclear Power Reactor Facilities' of Japan, based on knowledge from the 1995 Hyogoken-Nanbu Earthquake, and the conclusion that validity of the Guideline was confirmed. (J.P.N.)

  19. Experimental and numerical investigations of internal heat transfer in an innovative trailing edge blade cooling system: stationary and rotation effects, part 2: numerical results

    Science.gov (United States)

    Beniaiche, Ahmed; Ghenaiet, Adel; Carcasci, Carlo; Facchini, Bruno

    2017-02-01

    This paper presents a numerical validation of the aero-thermal study of a 30:1 scaled model reproducing an innovative trailing edge with one row of enlarged pedestals under stationary and rotating conditions. A CFD analysis was performed by means of commercial ANSYS-Fluent modeling the isothermal air flow and using k- ω SST turbulence model and an isothermal air flow for both static and rotating conditions (Ro up to 0.23). The used numerical model is validated first by comparing the numerical velocity profiles distribution results to those obtained experimentally by means of PIV technique for Re = 20,000 and Ro = 0-0.23. The second validation is based on the comparison of the numerical results of the 2D HTC maps over the heated plate to those of TLC experimental data, for a smooth surface for a Reynolds number = 20,000 and 40,000 and Ro = 0-0.23. Two-tip conditions were considered: open tip and closed tip conditions. Results of the average Nusselt number inside the pedestal ducts region are presented too. The obtained results help to predict the flow field visualization and the evaluation of the aero-thermal performance of the studied blade cooling system during the design step.

  20. The Pre-Depression Investigation of Cloud Systems in the Tropics (PREDICT) Experiment: Scientific Basis, New Analysis Tools and Some First Results (PREPRINT)

    Science.gov (United States)

    2011-01-01

    Adding the results of earlier efforts such as the Tropical Experiment in Mexico (TEXMEX; Bister and Emanuel 1997, Ray- mond et al. 1998) and even...Microphysics Icing rate Rosemount Liquid water content DMT King probe Cloud droplets/ice DMT CDP probe Ice particles PMS/DMT 2D-C Ice particles SPEC 3V

  1. Results of the investigation on validity of Japanese seismic design guidelines of nuclear facilities, based on the 1995 Hyogoken-Nanbu Earthquake

    Energy Technology Data Exchange (ETDEWEB)

    Watabe, Makoto [Keio Univ., Fujisawa, Kanagawa (Japan). Fac. of Environment and Information Engineering

    1997-03-01

    This paper describes the reviewed results and main discussions on some items thought to be problems in the `Examination Guide for Aseismatic Design of the Nuclear Power Reactor Facilities` of Japan, based on knowledge from the 1995 Hyogoken-Nanbu Earthquake, and the conclusion that validity of the Guideline was confirmed. (J.P.N.)

  2. Influence of previous participation in physical activity on its ...

    African Journals Online (AJOL)

    ... participation can influence perceptions of PA among the students. Physical activity promotion programmes should consider the role of these factors which should be emphasised from childhood. Keywords: physical activity, students, perceived benefits, perceived barriers, previous participation, sedentary lifestyle, Rwanda

  3. Choice of contraception after previous operative delivery at a family ...

    African Journals Online (AJOL)

    Choice of contraception after previous operative delivery at a family planning clinic in Northern Nigeria. Amina Mohammed‑Durosinlorun, Joel Adze, Stephen Bature, Caleb Mohammed, Matthew Taingson, Amina Abubakar, Austin Ojabo, Lydia Airede ...

  4. Payload specialist Reinhard Furrer show evidence of previous blood sampling

    Science.gov (United States)

    1985-01-01

    Payload specialist Reinhard Furrer shows evidence of previous blood sampling while Wubbo J. Ockels, Dutch payload specialist (only partially visible), extends his right arm after a sample has been taken. Both men show bruises on their arms.

  5. Delivery outcomes at term after one previous cesarean section.

    Science.gov (United States)

    Yamani-Zamzami, Tarik Y

    2007-12-01

    To determine the maternal and perinatal outcomes at term in women with one previous cesarean delivery and with no history of vaginal birth. This is a case-control study conducted at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia, between January 1, 1999 and December 31, 2002. One hundred sixty-two women with one previous cesarean delivery and with no previous vaginal birth were compared with 324 control women. The cesarean section rate was higher in the study group 40 (24.7%) versus 23 (7.1%) in the control group and was statistically significant (phistory of vaginal delivery are considered less favorable, the vaginal birth after cesarean section success rate may be even lower if the indication for previous primary cesarean delivery was failure to progress, and may be associated with increased risk of uterine rupture. Further study is required to confirm our findings.

  6. Nivolumab versus standard, single-agent therapy of investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related quality-of-life results from a randomised, phase 3 trial.

    Science.gov (United States)

    Harrington, Kevin J; Ferris, Robert L; Blumenschein, George; Colevas, A Dimitrios; Fayette, Jérôme; Licitra, Lisa; Kasper, Stefan; Even, Caroline; Vokes, Everett E; Worden, Francis; Saba, Nabil F; Kiyota, Naomi; Haddad, Robert; Tahara, Makoto; Grünwald, Viktor; Shaw, James W; Monga, Manish; Lynch, Mark; Taylor, Fiona; DeRosa, Michael; Morrissey, Laura; Cocks, Kim; Gillison, Maura L; Guigay, Joël

    2017-08-01

    Patients with platinum-refractory recurrent or metastatic squamous cell carcinoma of the head and neck have few treatment options and poor prognosis. Nivolumab significantly improved survival of this patient population when compared with standard single-agent therapy of investigator's choice in Checkmate 141; here we report the effect of nivolumab on patient-reported outcomes (PROs). CheckMate 141 was a randomised, open-label, phase 3 trial in patients with recurrent or metastatic squamous cell carcinoma of the head and neck who progressed within 6 months after platinum-based chemotherapy. Patients were randomly assigned (2:1) to nivolumab 3 mg/kg every 2 weeks (n=240) or investigator's choice (n=121) of methotrexate (40-60 mg/m 2 of body surface area), docetaxel (30-40 mg/m 2 ), or cetuximab (250 mg/m 2 after a loading dose of 400 mg/m 2 ) until disease progression, intolerable toxicity, or withdrawal of consent. On Jan 26, 2016, the independent data monitoring committee reviewed the data at the planned interim analysis and declared overall survival superiority for nivolumab over investigator's choice therapy (primary endpoint; described previously). The protocol was amended to allow patients in the investigator's choice group to cross over to nivolumab. All patients not on active therapy are being followed for survival. As an exploratory endpoint, PROs were assessed at baseline, week 9, and every 6 weeks thereafter using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30), the EORTC head and neck cancer-specific module (EORTC QLQ-H&N35), and the three-level European Quality of Life-5 Dimensions (EQ-5D) questionnaire. Differences within and between treatment groups in PROs were analysed by ANCOVA among patients with baseline and at least one other assessment. All randomised patients were included in the time to clinically meaningful deterioration analyses. Median time to clinically meaningful

  7. [Investigation of the effect of oxymetazoline on the duration of rhinitis. results of a placebo-controlled double-blind study in patients with acute rhinitis].

    Science.gov (United States)

    Reinecke, S; Tschaikin, M

    2005-10-06

    A prospective placebo-controlled double-blind study investigated the question whether oxymetazoline has a clinically relevant impact on the duration of acute rhinitis. The study included 247 patients with acute rhinitis who, over a maximum of 10 days, received either oxymetazoline hydrochloride (test substance group) or physiological saline solution applied in the form of a spray (control group). The main target measure was the duration of rhinitis, with time to onset of effect and symptoms as secondary measures. The safety of the treatment was determined on the basis of patient satisfaction, heart rate measurement, and undesired side effects recorded. The duration of the rhinitis decreased significantly under oxymetazoline in comparison with the control group (4 vs. 6 days). On average, the effect of oxymetazoline set in after 25 seconds, as compared with 90 seconds for physiological saline (difference significant, P oxymetazoline group, and were identical again in both arms of the study from the 9th day onward. The physicians assessed the efficacy of oxymetazoline to be good orvery good in 85% of the cases as compared with 38% for the physiological saline solution (P oxymetazoline group assessed the effect to be good or very good, as compared with 44% in the patients in the physiological saline group (P oxymetazoline to be significantly superior to physiological saline solution. Treatment with the former significantly shortened the duration of the rhinitis by one-third (2 days).

  8. Disparity in Cutaneous Pigmentary Response to LED vs Halogen Incandescent Visible Light: Results from a Single Center, Investigational Clinical Trial Determining a Minimal Pigmentary Visible Light Dose.

    Science.gov (United States)

    Soleymani, Teo; Cohen, David E; Folan, Lorcan M; Okereke, Uchenna R; Elbuluk, Nada; Soter, Nicholas A

    2017-11-01

    Background: While most of the attention regarding skin pigmentation has focused on the effects of ultraviolet radiation, the cutaneous effects of visible light (400 to 700nm) are rarely reported. The purpose of this study was to investigate the cutaneous pigmentary response to pure visible light irradiation, examine the difference in response to different sources of visible light irradiation, and determine a minimal pigmentary dose of visible light irradiation in melanocompetent subjects with Fitzpatrick skin type III - VI. The study was designed as a single arm, non-blinded, split-side dual intervention study in which subjects underwent visible light irradiation using LED and halogen incandescent light sources delivered at a fluence of 0.14 Watts/cm2 with incremental dose progression from 20 J/cm2 to 320 J/cm2. Pigmentation was assessed by clinical examination, cross-polarized digital photography, and analytic colorimetry. Immediate, dose-responsive pigment darkening was seen with LED light exposure in 80% of subjects, beginning at 60 Joules. No pigmentary changes were seen with halogen incandescent light exposure at any dose in any subject. This study is the first to report a distinct difference in cutaneous pigmentary response to different sources of visible light, and the first to demonstrate cutaneous pigment darkening from visible LED light exposure. Our findings raise the concern that our increasing daily artificial light surroundings may have clandestine effects on skin biology. J Drugs Dermatol. 2017;16(11):1105-1110..

  9. Preliminary results of the investigation “Women and Men Entrepreneurs in Science and Technology in Costa Rica: a contrast of gender realities”

    Directory of Open Access Journals (Sweden)

    Eugenia Ferreto-Gutiérrez

    2014-03-01

    Full Text Available The project is an investigation that seeks to demons­trate the contrasts of gender entrepreneurship on companies focused in Science and Technology in Costa Rica. By consulting secondary sources and experts on the topic, and deepen the field of Science and Technology. We have found a lack of documented information to take appropriate actions to guide the various actors involved at the level of Government, private sector and academia. In 2010, the Ministry of Economy, Industry and Commerce (MEIC launches two public policy of promoting SMEs and other enterprises to which state the issue of gender as a crosscutting issue. In addition, the Institute Tecnolológico Costa Rica (ITCR has defined support for SMEs and entre­preneurship as an institutional policy and transverse axis of its academic work (Institutional III Congress, which motivates venture into this line of research. Based on the above, this research proposal pretend at laying the foundations to make a gender contrast in entrepreneurs and their initiatives in science and technology and determine whether the differences or similarities impact on the performance of their companies.

  10. Is the fibrotic parietal thickening a reliable parameter for diagnosing previous asymptomatic deep vein thrombosis?

    Science.gov (United States)

    Quarto, Gennaro; Genovese, Giuseppe; Apperti, Marco; Amato, Bruno; Benassai, Giacomo; Furino, Ermenegildo

    2015-01-01

    Research of a starting point to debate about the possibility of identifying a unique sign of previous DVT. A retrospective study involving 202 outpatients with venous insufficiency of the lower limbs (CEAP classes C 4/6), classified according to the affected venous district. Patients positive for deep vein thrombosis (DVT) were subjected to Compression Ultra Sound test (CUS test) with measurement of the wall thickness at the point of formation of the thrombus and at fixed points of common femoral and popliteal veins used also in the patients with negative history of DVT RESULTS: Among total group, only 19 patients (9.40%) had an history of DVT. No one of them had a superficial incontinence. The measurement of wall thickness in positive DVT history patients (group A) resulted in an average value of 1.10 mm (s.d=0.06), while the average value obtained in negative DVT history (group B) was 0.55 mm (s.d.= 0.20). However, in 13 patients wall thickness was > 1mm (mean: 1.04 mm). The difference between the averages of group A and B was statistically significant (p 1 mm. Can the wall thickening more than 1 mm be considered an indicator of previous DVT? Can it be considered a "marker" for thrombophilia status? The usefulness of a sign of previous DVT (even if asymptomatic), detected during a routine Doppler ultrasound check of lower limbs, could be a warning bell to investigate thrombophilia status. Chronic Venous Insufficiency, Duplex ultrasound, Hypercoagulability, Post-thrombotic Syndrome, Venous Thromboembolism.

  11. Assessment of the value of electricity grids - Results of an investigation using enterprise data; Bewertung der Elektrizitaetsnetze - Ergebnisse einer Untersuchung von Unternehmensdaten

    Energy Technology Data Exchange (ETDEWEB)

    Schaerer, M. [PricewaterhouseCoopers, Basel (Switzerland); Kaufmann, I. [Nabholz Verwaltungsberatung, Zuerich (Switzerland); Flury, R. [BDO Visura, Lucerne (Switzerland)

    2002-07-01

    This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study made on the effects of different ways of evaluating the transmission fees for the use of electricity grids as foreseen in Swiss legislation on electricity market liberalisation. The study was made using enterprise data supplied by various distribution utilities. The sensitivity analysis made, with the capital costs of the grids as its kernel, is described. Four variants based on different combinations of basic assessment data and rates of interest are presented. The availability and quality of data is discussed, as is the large number of different utility types to be found in Switzerland. For the interpretation of the results of the study, two primary points of view are considered - that of the utility, focussed on future investments and their financing, and that of the consumer, focussed on pricing aspects. The report is concluded with recommendations on which models should be proposed for a future electricity market decree.

  12. Global Investigation of the Mg Atom and ion Layers using SCIAMACHY/Envisat Observations between 70 km and 150 km Altitude and WACCM-MG Model Results

    Science.gov (United States)

    Langowski, M.; vonSavigny, C.; Burrows, J. P.; Feng, W.; Plane, J. M. C.; Marsh, D. R.; Janches, Diego; Sinnhuber, M.; Aikin, A. C.

    2014-01-01

    Mg and Mg+ concentration fields in the upper mesosphere/lower thermosphere (UMLT) region are retrieved from SCIAMACHY/Envisat limb measurements of Mg and Mg+ dayglow emissions using a 2-D tomographic retrieval approach. The time series of monthly means of Mg and Mg+ for number density as well as vertical column density in different latitudinal regions are shown. Data from the limb mesosphere-thermosphere mode of SCIAMACHY/Envisat are used, which covers the 50 km to 150 km altitude region with a vertical sampling of 3.3 km and a highest latitude of 82 deg. The high latitudes are not covered in the winter months, because there is no dayglow emission during polar night. The measurements were performed every 14 days from mid-2008 until April 2012. Mg profiles show a peak at around 90 km altitude with a density between 750 cm(exp-3) and 2000 cm(exp-3). Mg does not show strong seasonal variation at mid-latitudes. The Mg+ peak occurs 5-15 km above the neutral Mg peak at 95-105 km. Furthermore, the ions show a significant seasonal cycle with a summer maximum in both hemispheres at mid- and high-latitudes. The strongest seasonal variations of the ions are observed at mid-latitudes between 20-40 deg and densities at the peak altitude range from 500 cm(exp-3) to 6000 cm(exp-3). The peak altitude of the ions shows a latitudinal dependence with a maximum at mid-latitudes that is up to 10 km higher than the peak altitude at the equator. The SCIAMACHY measurements are compared to other measurements and WACCM model results. In contrast to the SCIAMACHY results, the WACCM results show a strong seasonal variability for Mg with a winter maximum, which is not observable by SCIAMACHY, and globally higher peak densities. Although the peak densities do not agree the vertical column densities agree, since SCIAMACHY results show a wider vertical profile. The agreement of SCIAMACHY and WACCM results is much better for Mg+, showing the same seasonality and similar peak densities. However

  13. Summary of Previous Chamber or Controlled Anthrax Studies and Recommendations for Possible Additional Studies

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Amidan, Brett G.; Morrow, Jayne B.

    2010-12-29

    This report and an associated Excel file(a) summarizes the investigations and results of previous chamber and controlled studies(b) to characterize the performance of methods for collecting, storing and/or transporting, extracting, and analyzing samples from surfaces contaminated by Bacillus anthracis (BA) or related simulants. This report and the Excel are the joint work of the Pacific Northwest National Laboratory (PNNL) and the National Institute of Standards and Technology (NIST) for the Department of Homeland Security, Science and Technology Directorate. The report was originally released as PNNL-SA-69338, Rev. 0 in November 2009 with limited distribution, but was subsequently cleared for release with unlimited distribution in this Rev. 1. Only minor changes were made to Rev. 0 to yield Rev. 1. A more substantial update (including summarizing data from other studies and more condensed summary tables of data) is underway

  14. Visual pathway abnormalities were found in most multiple sclerosis patients despite history of previous optic neuritis

    Directory of Open Access Journals (Sweden)

    Stella Maris Costa Castro

    2013-07-01

    Full Text Available Objective It was to investigate visual field (VF abnormalities in a group of multiple sclerosis (MS patients in the remission phase and the presence of magnetic resonance imaging (MRI lesions in the optic radiations. Methods VF was assessed in 60 participants (age range 20-51 years: 35 relapsing-remitting MS patients [20 optic neuritis (+, 15 optic neuritis (-] and 25 controls. MRI (3-Tesla was obtained in all patients. Results Visual parameters were abnormal in MS patients as compared to controls. The majority of VF defects were diffuse. All patients except one had posterior visual pathways lesions. No significant difference in lesion number, length and distribution was noted between patients with and without history of optic neuritis. One patient presented homonymous hemianopsia. Conclusion Posterior visual pathway abnormalities were found in most MS patients despite history of previous optic neuritis.

  15. Influence of the Previous Preheating Temperature on the Static Coefficient of Friction with Lubrication

    Directory of Open Access Journals (Sweden)

    M. Živković

    2016-12-01

    Full Text Available Experimental investigations static coefficient of friction in lubricated conditions and pre-heating of the sample pin at high temperatures is discussed in this paper. The static coefficient of friction was measured in the sliding steel copper pins per cylinder of polyvinylchloride. Pins are previously heated in a special chamber from room temperature to a temperature of 800 oC with a step of 50 °C. Tribological changes in the surface layer of the pins caused by pre-heating the pins at high temperatures and cooling systems have very significantly influenced the increase in the coefficient of static friction. The results indicate the possibility of improving the friction characteristics of metal materials based on their thermal treatment at elevated temperatures.

  16. Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.

    Directory of Open Access Journals (Sweden)

    Tomas Kirchhoff

    Full Text Available Recently, a locus on chromosome 6q22.33 (rs2180341 was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC. In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA. Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR = 1.03, 95% CI 1.00-1.06, p = 0.023. There was evidence for heterogeneity in the ORs among studies (I(2 = 49.3%; p = <0.004. In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048, indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.

  17. Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).

    Science.gov (United States)

    Salihovic, Samira; Kärrman, Anna; Lind, Lars; Lind, P Monica; Lindström, Gunilla; van Bavel, Bert

    2015-09-01

    Per- and polyfluoroalkyl substances (PFASs) are a class of compounds with unique chemical properties that have been shown useful in a wide variety of applications because they provide materials with reduced surface tension and exceptional non-stick properties. PFASs are commonly found in impregnation materials, coatings of papers and textiles, fire-fighting foams, pesticides, and cleaning agents. The potential for human exposure to PFASs is high because of their widespread distribution. The aim of this study was to investigate levels of PFASs in men and women from Sweden and to assess the influence of gender and parity among women. Levels of 13 PFASs were determined in plasma samples collected during 2001-2004 from 1016 (507 women) 70year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). The PFASs studied were nine perfluorinated carboxylic acids (PFCAs), four perfluorinated sulfonic acids (PFSAs) and perfluorooctane sulfonamide (PFOSA). In addition, structural isomers of perfluorooctane sulfonic acid (PFOS) were determined in a subset of 398 individuals. The detection rates were high and the majority of the studied compounds were detected in more than 75% of the participants. Levels of the selected analytes were found to be similar to other studies of non-occupationally exposed populations. Gender differences were observed in levels of PFHpA which was higher in men, while PFHxS was higher in women. Parity among women was shown to have a minor effect on PFAS concentrations and we found primi- and multiparous women to have slightly lower levels of PFUnDA when compared to nulliparous women. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Investigation of a Ca2+ channel α2δ ligand for the treatment of interstitial cystitis: results of a randomized, double-blind, placebo controlled phase II trial.

    Science.gov (United States)

    Nickel, J Curtis; Crossland, Anna; Davis, Edward; Haab, François; Mills, Ian W; Rovner, Eric; Scholfield, David; Crook, Tim

    2012-09-01

    We investigated PD-0299685, a Ca(2+) channel α2δ ligand, for interstitial cystitis pain in a randomized, double-blind, placebo controlled phase IIa study. Patients with interstitial cystitis/bladder pain syndrome received 30 or 60 mg PD-0299685 daily or placebo for 12 weeks. Primary end points were change in average daily worst pain severity score (on an 11-point numerical rating scale) and change in Interstitial Cystitis Symptom Index score from baseline to week 12. Secondary end points included global response assessment, micturition and urgency episode frequency per 24 hours and mean voided volume per micturition. Incidence of adverse events was also assessed. Of 161 patients 54 received 30 mg PD-0299685 daily, 55 received 60 mg PD-0299685 daily and 52 received placebo. At week 12 the 60 mg dose produced a clinically significant reduction in daily worst pain severity score from baseline compared to placebo (treatment difference [90% CI] -0.82 [-1.72, 0.08]). A greater proportion of patients taking 60 mg PD-0299685 daily demonstrated improvement in global response assessment. PD-0299685 had no clinically significant effect on the Interstitial Cystitis Symptom Index score or urinary end points. More patients discontinued due to treatment related adverse events with 30 or 60 mg PD-0299685 daily than with the placebo. PD-0299685 failed to demonstrate positive proof of concept for the treatment of pain and other urinary end points associated with interstitial cystitis/bladder pain syndrome. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  19. Repeat immigration: A previously unobserved source of heterogeneity?

    Science.gov (United States)

    Aradhya, Siddartha; Scott, Kirk; Smith, Christopher D

    2017-07-01

    Register data allow for nuanced analyses of heterogeneities between sub-groups which are not observable in other data sources. One heterogeneity for which register data is particularly useful is in identifying unique migration histories of immigrant populations, a group of interest across disciplines. Years since migration is a commonly used measure of integration in studies seeking to understand the outcomes of immigrants. This study constructs detailed migration histories to test whether misclassified migrations may mask important heterogeneities. In doing so, we identify a previously understudied group of migrants called repeat immigrants, and show that they differ systematically from permanent immigrants. In addition, we quantify the degree to which migration information is misreported in the registers. The analysis is carried out in two steps. First, we estimate income trajectories for repeat immigrants and permanent immigrants to understand the degree to which they differ. Second, we test data validity by cross-referencing migration information with changes in income to determine whether there are inconsistencies indicating misreporting. From the first part of the analysis, the results indicate that repeat immigrants systematically differ from permanent immigrants in terms of income trajectories. Furthermore, income trajectories differ based on the way in which years since migration is calculated. The second part of the analysis suggests that misreported migration events, while present, are negligible. Repeat immigrants differ in terms of income trajectories, and may differ in terms of other outcomes as well. Furthermore, this study underlines that Swedish registers provide a reliable data source to analyze groups which are unidentifiable in other data sources.

  20. Serratia liquefaciens Infection of a Previously Excluded Popliteal Artery Aneurysm

    Directory of Open Access Journals (Sweden)

    A. Coelho

    Full Text Available : Introduction: Popliteal artery aneurysms (PAAs are rare in the general population, but they account for nearly 70% of peripheral arterial aneurysms. There are several possible surgical approaches including exclusion of the aneurysm and bypass grafting, or endoaneurysmorrhaphy and interposition of a prosthetic conduit. The outcomes following the first approach are favorable, but persistent blood flow in the aneurysm sac has been documented in up to one third of patients in the early post-operative setting. Complications from incompletely excluded aneurysms include aneurysm enlargement, local compression symptoms, and sac rupture. Notably infection of a previously excluded and bypassed PAA is rare. This is the third reported case of PAA infection after exclusion and bypass grafting and the first due to Serratia liquefaciens. Methods: Relevant medical data were collected from the hospital database. Results: This case report describes a 54 year old male patient, diagnosed with acute limb ischaemia due to a thrombosed PAA, submitted to emergency surgery with exclusion and venous bypass. A below the knee amputation was necessary 3 months later. Patient follow-up was lost until 7 years following surgical repair, when he was diagnosed with aneurysm sac infection with skin fistulisation. He had recently been diagnosed with alcoholic hepatic cirrhosis Child–Pugh Class B. The patient was successfully treated by aneurysm resection, soft tissue debridement and systemic antibiotics. Conclusion: PAA infection is a rare complication after exclusion and bypass procedures but should be considered in any patient with evidence of local or systemic infection. When a PAA infection is diagnosed, aneurysmectomy, local debridement, and intravenous antibiotic therapy are recommended. The “gold standard” method of PAA repair remains controversial. PAA excision or endoaneurysmorrhaphy avoids complications from incompletely excluded aneurysms, but is associated with

  1. Sacrococcygeal pilonidal disease: analysis of previously proposed risk factors

    Directory of Open Access Journals (Sweden)

    Ali Harlak

    2010-01-01

    Full Text Available PURPOSE: Sacrococcygeal pilonidal disease is a source of one of the most common surgical problems among young adults. While male gender, obesity, occupations requiring sitting, deep natal clefts, excessive body hair, poor body hygiene and excessive sweating are described as the main risk factors for this disease, most of these need to be verified with a clinical trial. The present study aimed to evaluate the value and effect of these factors on pilonidal disease. METHOD: Previously proposed main risk factors were evaluated in a prospective case control study that included 587 patients with pilonidal disease and 2,780 healthy control patients. RESULTS: Stiffness of body hair, number of baths and time spent seated per day were the three most predictive risk factors. Adjusted odds ratios were 9.23, 6.33 and 4.03, respectively (p<0.001. With an adjusted odds ratio of 1.3 (p<.001, body mass index was another risk factor. Family history was not statistically different between the groups and there was no specific occupation associated with the disease. CONCLUSIONS: Hairy people who sit down for more than six hours a day and those who take a bath two or less times per week are at a 219-fold increased risk for sacrococcygeal pilonidal disease than those without these risk factors. For people with a great deal of hair, there is a greater need for them to clean their intergluteal sulcus. People who engage in work that requires sitting in a seat for long periods of time should choose more comfortable seats and should also try to stand whenever possible.

  2. RESULTS OF CALCULATION-EXPERIMENTAL INVESTIGATIONS OF ELECTRO-THERMAL RESISTIBILITY OF SHEET STEEL SAMPLES TO ACTION OF RATIONED COMPONENTS OF PULSED CURRENT OF ARTIFICIAL LIGHTING

    Directory of Open Access Journals (Sweden)

    M.I. Baranov

    2016-06-01

    Full Text Available Purpose. Calculation and experimental researches of the electro-thermal resistibility of the steel sheet samples to action standard pulse current components of the artificial lightning with amplitude-time parameters (ATP, corresponded the requirements of normative documents of USA for SAE ARP 5412 & SAE ARP 5416. Methodology. Electrophysics bases of technique of high tensions and large impulsive currents (LIC, and also scientific and technical bases of planning of devices of high-voltage impulsive technique and measuring in them LIC. Сurrent amplitude ImA=±200 kA (with a tolerance of ±10 %; current action integral JA=2∙106 A2•s (with a tolerance of ±20 %; time, corresponding to the amplitude of the current ImA, tmA≤50 microseconds; the duration of the current flow τpA≤500 microseconds. Results. The results of the evaluation of the calculated and experimental studies of electro-thermal resistance of the samples of plates measuring 0,5 m  0,5 m stainless steel 1 mm thickness to the action on them artificial lightning impulse currents with rationed ATP on the requirements of normative documents of USA for SAE ARP 5412 & SAE ARP 5416. A pulse A- component have a first amplitude 192 kA, the corresponding time of 34 μs, and the duration aperiodic component amplitude 804 A, corresponding to the time 9 ms. It has been shown that the long C- component current of artificial lightning can lead to keyhole these samples. The diameter of the holes in this thin steel sheet, which is formed during the flow of current C- components can reach 15 mm. The results of calculation and experiment agree within 28 %. Originality. For the first time in world practice on the generator large pulsed currents experimental studies of resistibility of sheet steel samples to the action of artificial lightning currents with critical parameters. Practical value. Using the results obtained in the practice of lightning protection will significantly improve the

  3. Global investigation of the Mg atom and ion layers using SCIAMACHY/Envisat observations between 70 and 150 km altitude and WACCM-Mg model results

    Directory of Open Access Journals (Sweden)

    M. P. Langowski

    2015-01-01

    Full Text Available Mg and Mg+ concentration fields in the upper mesosphere/lower thermosphere (UMLT region are retrieved from SCIAMACHY/Envisat limb measurements of Mg and Mg+ dayglow emissions using a 2-D tomographic retrieval approach. The time series of monthly mean Mg and Mg+ number density and vertical column density in different latitudinal regions are presented. Data from the limb mesosphere–thermosphere mode of SCIAMACHY/Envisat are used, which cover the 50 to 150 km altitude region with a vertical sampling of ≈3.3 km and latitudes up to 82°. The high latitudes are not observed in the winter months, because there is no dayglow emission during polar night. The measurements were performed every 14 days from mid-2008 until April 2012. Mg profiles show a peak at around 90 km altitude with a density between 750 cm−3 and 1500 cm−3. Mg does not show strong seasonal variation at latitudes below 40°. For higher latitudes the density is lower and only in the Northern Hemisphere a seasonal cycle with a summer minimum is observed. The Mg+ peak occurs 5–15 km above the neutral Mg peak altitude. These ions have a significant seasonal cycle with a summer maximum in both hemispheres at mid and high latitudes. The strongest seasonal variations of Mg+ are observed at latitudes between 20 and 40° and the density at the peak altitude ranges from 500 cm−3 to 4000 cm−3. The peak altitude of the ions shows a latitudinal dependence with a maximum at mid latitudes that is up to 10 km higher than the peak altitude at the equator. The SCIAMACHY measurements are compared to other measurements and WACCM model results. The WACCM results show a significant seasonal variability for Mg with a summer minimum, which is more clearly pronounced than for SCIAMACHY, and globally a higher peak density than the SCIAMACHY results. Although the peak density of both is not in agreement, the vertical column density agrees well, because SCIAMACHY and WACCM profiles have different

  4. Assessment of carbon dioxide sink/source in the oceanic areas: the results of 1982-84 investigation. Final technical report

    International Nuclear Information System (INIS)

    Takahashi, T.; Chipman, D.W.; Smethie, W. Jr.; Goddard, J.; Trumbore, S.; Mathieu, G.G.; Sutherland, S.

    1985-07-01

    The oceanic CO 2 sink/source relationships over the tropical Atlantic Ocean, the eastern North and South Pacific Ocean, and the Ross Sea were investigated. The net CO 2 flux across the air-sea interface over these areas was estimated. Measurements of the Kr-85 in atmospheric samples collected over the central Pacific along the 155 0 W meridian were initiated. Based on the measurements of the difference between the pCO 2 values in the surface ocean water and the atmosphere and of the radon-222 distribution in the upper water column, we have found that the average net flux for the Atlantic equatorial belt, 10 0 N-10 0 S, is 1.3 moles CO 2 /m 2 .y out of the ocean, when our measurements were made in November 1982 through February 1983. The surface water pCO 2 data obtained over the eastern North and South Pacific during the period, October 1983 through January 1984, show that the equatorial zone between 2 0 N and 8 0 S is an intense CO 2 source area, whereas a 10 0 wide belt coinciding with the area between the Subtropical and Antarctic Convergence Zones is a strong CO 2 sink area. The temperate gyre area located north of about 5 0 N and that located between 8 0 S and 35 0 S are nearly in equilibrium with atmospheric CO 2 . The surface water pCO 2 data obtained in the Southern Ocean during the past ten or more years suggest strongly the existence of an intense CO 2 sink zone, the Circumpolar Low pCO 2 Zone, which is about 10 0 wide in latitude and centered at about 50 0 S surrounding the Antarctica Continent. The surface water of the Ross Sea is found to be a strong CO 2 sink during the period January 23 through February 12, 1984. Because of contamination problems, no reliable data for atmospheric krypton-85 have been obtained. 23 refs., 22 figs., 3 tabs

  5. El parlache: resultados de una investigación lexicográfica The ‘parlache’: Results of a lexicographical investigation

    Directory of Open Access Journals (Sweden)

    LUZ STELLA CASTAÑEDA

    2005-06-01

    Full Text Available La idea de realizar una investigación sobre la caracterización lexicográfica del parlache, con el fin de elaborar un diccionario, se debe al interés de profundizar en el estudio de una variedad dialectal de origen diastrático, del español colombiano, denominada parlache, que utilizan amplios sectores de la sociedad, pero en especial los jóvenes de los barrios populares y marginales de Medellín y de su Área Metropolitana. En toda sociedad se presentan cambios lingüísticos que van mostrando las transformaciones de la realidad. Ahora bien, en los sectores populares y marginales de Medellín, el surgimiento de los cambios lingüísticos fue tan acelerado, que desbordó los límites normales de este fenómeno debido a la agudización de la crisis social y al surgimiento de nuevas formas de “trabajo”, caracterizadas por un marco de trasgresión de la ley y por un amplio dominio de la cultura de la droga, en donde el sector social más afectado ha sido el de los jóvenes. Por esto, a pesar de que el parlache es una variedad dialectal muy extendida, la mayor parte de sus hablantes y los que lo usan con mayor propiedad son los jóvenes entre 15 y 26 años.The idea of carrying out an investigation on the lexicographical characterization of the parlache in order to elaborate a dictionary, was born by the interest in searching thoroughly on a dialectal variety of diastratic origin from the Colombian Spanish, called parlache, which is widely used by our society, but specifically by youth of popular and outskirt neighbourhoods of Medellin and its metropolitan area. In all the society linguistic changes are occurring which show the transformation of their reality. As a matter of fact, the occurrence of linguistic change in the popular and outskirt districts of Medellin advanced so fast that it surpassed the commonl limits of this phenomenon, due to the worsening of the social crisis, the upspring of new kinds of “work”, marked by legal

  6. Effects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: results from two randomized trials.

    Science.gov (United States)

    Van Damme, Pierre; Leroux-Roels, Geert; Simon, Philippe; Foidart, Jean-Michel; Donders, Gilbert; Hoppenbrouwers, Karel; Levin, Myron; Tibaldi, Fabian; Poncelet, Sylviane; Moris, Philippe; Dessy, Francis; Giannini, Sandra L; Descamps, Dominique; Dubin, Gary

    2014-06-17

    A prophylactic human papillomavirus (HPV) vaccine targeting oncogenic HPV types in addition to HPV-16 and -18 may broaden protection against cervical cancer. Two Phase I/II, randomized, controlled studies were conducted to compare the immunogenicity and safety of investigational tetravalent HPV L1 virus-like particle (VLP) vaccines, containing VLPs from two additional oncogenic genotypes, with the licensed HPV-16/18 AS04-adjuvanted vaccine (control) in healthy 18-25 year-old women. In one trial (NCT00231413), subjects received control or one of 6 tetravalent HPV-16/18/31/45 AS04 vaccine formulations at months (M) 0,1,6. In a second trial (NCT00478621), subjects received control or one of 5 tetravalent HPV-16/18/33/58 vaccines formulated with different adjuvant systems (AS04, AS01 or AS02), administered on different schedules (M0,1,6 or M0,3 or M0,6). One month after the third injection (Month 7), there was a consistent trend for lower anti-HPV-16 and -18 geometric mean antibody titers (GMTs) for tetravalent AS04-adjuvanted vaccines compared with control. GMTs were statistically significantly lower for an HPV-16/18/31/45 AS04 vaccine containing 20/20/10/10 μg VLPs for both anti-HPV-16 and anti-HPV-18 antibodies, and for an HPV-16/18/33/58 AS04 vaccine containing 20/20/20/20 μg VLPs for anti-HPV-16 antibodies. There was also a trend for lower HPV-16 and -18-specific memory B-cell responses for tetravalent AS04 vaccines versus control. No such trends were observed for CD4(+) T-cell responses. Immune interference could not always be overcome by increasing the dose of HPV-16/18 L1 VLPs or by using a different adjuvant system. All formulations had acceptable reactogenicity and safety profiles. Reactogenicity in the 7-day post-vaccination period tended to increase with the introduction of additional VLPs, especially for formulations containing AS01. HPV-16 and -18 antibody responses were lower when additional HPV L1 VLPs were added to the HPV-16/18 AS04-adjuvanted

  7. The frequency of cartilage lesions in non-injured knees with symptomatic meniscus tears: results from an arthroscopic and NIR- (near-infrared) spectroscopic investigation.

    Science.gov (United States)

    Spahn, Gunter; Plettenberg, Holger; Hoffmann, Martin; Klemm, Holm-Torsten; Brochhausen-Delius, Christoph; Hofmann, Gunther O

    2017-06-01

    Are symptomatic tear injuries to the menisci of the knee frequently or always associated with cartilage damage to the corresponding articular surfaces and other joint surfaces, respectively? A total of 137 patients (medial n = 127; lateral n = 10) underwent a meniscus resection. These patients showed no signs of a clear radiographic arthrosis and no MRI-detectable cartilage lesions > grade II. Traumatic injury was ruled out with a thorough medical history. The indication for operation was made exclusively on the basis of distinct, clinically apparent meniscus signs. In addition to the ICRS classification, all articular surfaces were examined spectroscopically (NIRS, near-infrared spectroscopy). In 76.6% (n = 105) of all knees examined, clear cartilage damage (ICRS-grade III/IV) was found. For 43.8%, these were in the area of the patella, while for 34.3% they were in the area of the medial femur, and for 17.5%, in the area of the medial tibial plateau. More rarely, this damage was localized to the area of the trochlea (8.8%) or the lateral joint compartment (femoral 2.2%, tibial 15.3%). There were no significant differences between patients with medial or lateral meniscus lesions with respect to the distribution pattern of the joint injuries. During spectroscopic examination, pathological values were demonstrated (objective evidence of cartilage degeneration) in at least one of the examined articular surfaces (media n = 6, range 1-6). Through our investigations, a high, if not complete, concomitance of degenerative cartilage lesions and degenerative meniscus damage was demonstrated. From this it can be concluded that the entity of "isolated degenerative meniscus damage" clearly does not exist in practice. It is therefore highly probable that degenerative meniscus lesions, as a part of general joint degeneration, are to be interpreted in the context of the development of arthrosis. The practical consequences still are unclear. Patients after partial

  8. The grain size dependency of vesicular particle shapes strongly affects the drag of particles. First results from microtomography investigations of Campi Flegrei fallout deposits

    Science.gov (United States)

    Mele, Daniela; Dioguardi, Fabio

    2018-03-01

    Acknowledging the grain size dependency of shape is important in volcanology, in particular when dealing with tephra produced and emplaced during and after explosive volcanic eruptions. A systematic measurement of the tridimensional shape of vesicular pyroclasts of Campi Flegrei fallout deposits (Agnano-Monte Spina, Astroni 6 and Averno 2 eruptions) varying in size from 8.00 to 0.016 mm has been carried out by means of X-Ray Microtomography. Data show that particle shape changes with size, especially for juvenile vesicular clasts, since it is dependent on the distribution and size of vesicles that contour the external clast outline. Two drag laws that include sphericity in the formula were used for estimating the dependency of settling velocity on shape. Results demonstrate that it is not appropriate to assume a size-independent shape for vesicular particles, in contrast with the approach commonly employed when simulating the ash dispersion in the atmosphere.

  9. Investigations of subterranean microorganisms and their importance for performance assessment of radioactive waste disposal. Results and conclusions achieved during the period 1995 to 1997

    International Nuclear Information System (INIS)

    Pedersen, K.

    1997-11-01

    In 1987, microbiology became a part of the Swedish scientific program for the safe disposal of high level nuclear waste (HLW). The goal of the microbiology sub-program is to understand how subterranean microorganisms will interact with the performance of a future HLW repository. The Swedish research program on subterranean microbiology has mainly been performed at two sites in granitic rock aquifers at depths ranging from 70 m down to 1240 m; the Stripa research mine in the middle of Sweden and the Aespoe hard rock laboratory (HRL) situated on the south eastern coast of Sweden. Some work has also been performed in co-operation with other national or international research groups in Sweden, Canada and at the natural analogue sites in Oklo in Gabon and Maqarin in Jordan. The most recent report in the SKB technical report series on microbiology and performance assessment, SKB-TR--95-10, gave the state of the art regarding microorganisms and their importance for performance assessment. That report is recommended as a source of knowledge about basic microbiology, microbial ecology of subterranean environments and the nuclear waste disposal concept in a microbiological perspective. The present report summarises results and conclusions achieved during the period 1995 to 1997 and is a continuation of SKB TR 95-10. The report is structured as summary which explains and analyses the obtained results and conclusions in a performance assessment perspective. The scientific basis for the summary is an enclosed series of eleven papers of which eight have gone through an international peer review process for publication in international scientific journals and reports and papers published earlier

  10. Investigations of subterranean microorganisms and their importance for performance assessment of radioactive waste disposal. Results and conclusions achieved during the period 1995 to 1997

    Energy Technology Data Exchange (ETDEWEB)

    Pedersen, K. [Goeteborg Univ. (Sweden). Dept. of General and Marine Microbiology

    1997-11-01

    In 1987, microbiology became a part of the Swedish scientific program for the safe disposal of high level nuclear waste (HLW). The goal of the microbiology sub-program is to understand how subterranean microorganisms will interact with the performance of a future HLW repository. The Swedish research program on subterranean microbiology has mainly been performed at two sites in granitic rock aquifers at depths ranging from 70 m down to 1240 m; the Stripa research mine in the middle of Sweden and the Aespoe hard rock laboratory (HRL) situated on the south eastern coast of Sweden. Some work has also been performed in co-operation with other national or international research groups in Sweden, Canada and at the natural analogue sites in Oklo in Gabon and Maqarin in Jordan. The most recent report in the SKB technical report series on microbiology and performance assessment, SKB-TR--95-10, gave the state of the art regarding microorganisms and their importance for performance assessment. That report is recommended as a source of knowledge about basic microbiology, microbial ecology of subterranean environments and the nuclear waste disposal concept in a microbiological perspective. The present report summarises results and conclusions achieved during the period 1995 to 1997 and is a continuation of SKB TR 95-10. The report is structured as summary which explains and analyses the obtained results and conclusions in a performance assessment perspective. The scientific basis for the summary is an enclosed series of eleven papers of which eight have gone through an international peer review process for publication in international scientific journals and reports and papers published earlier. 413 refs, 56 figs, 39 tabs.

  11. Prostatic arterial embolization for the treatment of lower urinary tract symptoms as a result of large benign prostatic hyperplasia: A prospective single-center investigation.

    Science.gov (United States)

    Wang, Maoqiang; Guo, Liping; Duan, Feng; Yuan, Kai; Zhang, Guodong; Li, Kai; Yan, Jieyu; Wang, Yan; Kang, Haiyan; Wang, Zhijun

    2015-08-01

    To evaluate the effectiveness and safety of prostatic arterial embolization as a primary treatment for patients with lower urinary tract symptoms as a result of large benign prostatic hyperplasia. A total of 64 patients with prostates >80 mL were included in the study. Prostatic arterial embolization was carried out using a combination of 50-µm and 100-µm particles. Clinical follow up was carried out using the International Prostate Symptom Score, quality of life, peak urinary flow, postvoid residual volume, International Index of Erectile Function Short Form, prostate-specific antigen, and prostatic volume at 1, 3, 6 and every 6 months thereafter. Prostatic arterial embolization was technically successful in 60 of 64 patients (93.8%). Follow-up data were available for 60 patients with a mean of 18 months. A clinical improvement, defined as reduction of International Prostate Symptom Score and increase of peak urinary flow, at 1 month, 3 months, 6 months, 12 months and 24 months, was achieved in 95.0%, 95.0%, 93.3%, 92.6% and 90.5%, respectively. A total of 42 patients had completed the follow up at 24 months after prostatic arterial embolization. There was an improvement in terms of mean International Prostate Symptom Score (pre-prostatic arterial embolization vs post-prostatic arterial embolization 27.0 vs 8.0; P prostatic volume (121.0 vs 71.5, reduction of 40.9%; P Prostatic arterial embolization seems to be a safe and effective treatment method for patients with lower urinary tract symptoms as a result of large benign prostatic hyperplasia, and it might play an important role for patients in whom medical therapy has failed, who are not candidates for surgical treatment. © 2015 The Japanese Urological Association.

  12. Sarcopenia and Endothelial Function in Patients With Chronic Heart Failure: Results From the Studies Investigating Comorbidities Aggravating Heart Failure (SICA-HF).

    Science.gov (United States)

    Dos Santos, Marcelo R; Saitoh, Masakazu; Ebner, Nicole; Valentova, Miroslava; Konishi, Masaaki; Ishida, Junichi; Emami, Amir; Springer, Jochen; Sandek, Anja; Doehner, Wolfram; Anker, Stefan D; von Haehling, Stephan

    2017-03-01

    Skeletal muscle wasting, also known as sarcopenia, has recently been identified as a serious comorbidity in patients with heart failure (HF). We aimed to assess the impact of sarcopenia on endothelial dysfunction in patients with HF with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). Cross-sectional study. Ambulatory patients with HF were recruited at Charité Medical School, Campus Virchow-Klinikum, Berlin, Germany. We assessed peripheral blood flow (arm and leg) in 228 patients with HF and 32 controls who participated in the Studies Investigating Comorbidities Aggravating HF (SICA-HF). The appendicular skeletal muscle mass of the arms and the legs combined was assessed by dual energy x-ray absorptiometry (DEXA). Sarcopenia was defined as the appendicular muscle mass two standard deviations below the mean of a healthy reference group of adults aged 18 to 40 years, as suggested for the diagnosis of muscle wasting in healthy aging. All patients underwent a 6-minute walk test and spiroergometry testing. Forearm and leg blood flow were measured by venous occlusion plethysmography. Peak blood flow was assessed after a period of ischemia in the limbs to test endothelial function. Sarcopenia was identified in 37 patients (19.5%). Patients with sarcopenia presented with lower baseline forearm blood flow (2.30 ± 1.21 vs. 3.06 ± 1.49 vs. 4.00 ± 1.66 mL min -1 100 mL -1 ; P = .02) than those without sarcopenia or controls. The group of patients with sarcopenia showed similar baseline leg blood flow (2.06 ± 1.62 vs. 2.39 ± 1.39 mL min -1 100 mL -1 ; P = .11) to those without but lower values when compared to controls (2.06 ± 1.62 vs. 2.99 ± 1.28 mL min -1 100 mL -1 ; P = .03). In addition, patients with and without sarcopenia presented with lower peak flow in the forearm when compared to controls (18.37 ± 7.07 vs. 22.19 ± 8.64 vs. 33.63 ± 8.57 mL min -1 100 mL -1 ; P sarcopenia, and coronary artery

  13. What Predicts Patients’ Willingness to Undergo Online Treatment and Pay for Online Treatment? Results from a Web-Based Survey to Investigate the Changing Patient-Physician Relationship

    Science.gov (United States)

    Bidmon, Sonja; Terlutter, Ralf

    2016-01-01

    Background Substantial research has focused on patients’ health information–seeking behavior on the Internet, but little is known about the variables that may predict patients’ willingness to undergo online treatment and willingness to pay additionally for online treatment. Objective This study analyzed sociodemographic variables, psychosocial variables, and variables of Internet usage to predict willingness to undergo online treatment and willingness to pay additionally for online treatment offered by the general practitioner (GP). Methods An online survey of 1006 randomly selected German patients was conducted. The sample was drawn from an e-panel maintained by GfK HealthCare. Missing values were imputed; 958 usable questionnaires were analyzed. Variables with multi-item measurement were factor analyzed. Willingness to undergo online treatment and willingness to pay additionally for online treatment offered by the GP were predicted using 2 multiple regression models. Results Exploratory factor analyses revealed that the disposition of patients’ personality to engage in information-searching behavior on the Internet was unidimensional. Exploratory factor analysis with the variables measuring the motives for Internet usage led to 2 separate factors: perceived usefulness (PU) of the Internet for health-related information searching and social motives for information searching on the Internet. Sociodemographic variables did not serve as significant predictors for willingness to undergo online treatment offered by the GP, whereas PU (B=.092, P=.08), willingness to communicate with the GP more often in the future (B=.495, Ponline communication with the GP (B=.198, Ponline treatment, but it was predicted by health-related information–seeking personality (B=.127, P=.07), PU (B=–.098, P=.09), willingness to undergo online treatment (B=.391, Ponline communication with the GP (B=.192, P=.001), highest education level (B=.178, Ponline more often in the future (B

  14. Association of Aortic Valve Sclerosis with Previous Coronary Artery Disease and Risk Factors

    Directory of Open Access Journals (Sweden)

    Filipe Carvalho Marmelo

    2014-11-01

    Full Text Available Background: Aortic valve sclerosis (AVS is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. Several studies show an association between AVS and presence of coronary artery disease. Objective: The aim of this study is to investigate the association between presence of AVS with occurrence of previous coronary artery disease and classical risk factors. Methods: The sample was composed of 2,493 individuals who underwent transthoracic echocardiography between August 2011 and December 2012. The mean age of the cohort was 67.5 ± 15.9 years, and 50.7% were female. Results: The most frequent clinical indication for Doppler echocardiography was the presence of stroke (28.8%, and the most common risk factor was hypertension (60.8%. The most prevalent pathological findings on Doppler echocardiography were mitral valve sclerosis (37.1% and AVS (36.7%. There was a statistically significant association between AVS with hypertension (p < 0.001, myocardial infarction (p = 0.007, diabetes (p = 0.006 and compromised left ventricular systolic function (p < 0.001. Conclusion: Patients with AVS have higher prevalences of hypertension, stroke, hypercholesterolemia, myocardial infarction, diabetes and compromised left ventricular systolic function when compared with patients without AVS. We conclude that there is an association between presence of AVS with previous coronary artery disease and classical risk factors.

  15. Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats

    Science.gov (United States)

    Gallardo-Calero, Irene; López-Fernández, Alba; Romagosa, Cleofe; Vergés, Ramona; Aguirre-Canyadell, Marius; Soldado, Francisco; Velez, Roberto

    2016-01-01

    Background: The objective of the present investigation was to compare the effect of neoadjuvant irradiation on the microvascular anastomosis in cervical bundle using an experimental model in rats. Methods: One hundred forty male Sprague–Dawley rats were allocated into 4 groups: group I, control, arterial microanastomosis; group II, control, venous microanastomosis; group III, arterial microanastomosis with previous irradiation (20 Gy); and group IV, venous microanastomosis with previous irradiation (20 Gy). Clinical parameters, technical values of anastomosis, patency, and histopathological parameters were evaluated. Results: Irradiated groups (III and IV) and vein anastomosis groups (II and IV) showed significantly increased technical difficulties. Group IV showed significantly reduced patency rates (7/35) when compared with the control group (0/35). Radiotherapy significantly decreased the patency rates of the vein (7/35) when compared with the artery (1/35). Groups III and IV showed significantly reduced number of endothelial cells and also showed the presence of intimal thickening and adventitial fibrosis as compared with the control group. Conclusion: Neoadjuvant radiotherapy reduces the viability of the venous anastomosis in a preclinical rat model with a significant increase in the incidence of vein thrombosis. PMID:27975009

  16. Surface-water-quality assessment of the upper Illinois River Basin in Illinois, Indiana, and Wisconsin; results of investigations through April 1992

    Science.gov (United States)

    Schmidt, Arthur R.; Blanchard, Stephen F.

    1997-01-01

    A water-quality assessment of the upper Illinois River Basin (10,949 square miles) was conducted during water years 1987-91. This assessment involved interpretation of available data; 4 years of intensive data collection, including monthly sample collection at eight fixed-monitoring stations in the basin; and synoptic studies of selected water-quality constituents at many sites. The number of exceedances of water-quality criteria for chromium, copper, lead, mercury, silver, and zinc in water was essentially the same at similar stations between 1978-86 and 1987-90. For water and sediment, a large signature for many trace inorganic constituents was observed from the Chicago metropolitan area, mainly from the Des Plaines River Basin and continuing down the Illinois River. Loads of trace inorganic constituents in water were 2-13 times greater from the Chicago metropolitan area than from rural areas in the upper Illinois River Basin. Concentrations of cadmium, mercury, nickel, selenium, and zinc appeared to be relatively enriched in biota in the upper Illinois River Basin compared to other river basins. Biota from some urban sites were enriched with respect to several elements. For example, relatively large concentrations of cadmium, chromium, copper, lead, and nickel were observed in biota from sites in the Chicago River in the metropolitan area and the Calumet River. Results of pesticide sampling in 1988 and 1989 identified the pesticides bromacil, diazinon, malathion, prometon, and simazine as urban related and alachlor, atrazine, cyanazine, metolachlor, and metribuzin as agricultural related. Phenol concentrations never exceeded general-use and secondary-contact water-quality standards of 100 and 300 micrograms per liter, respectively. Pentachlorophenol concentrations observed at the Illinois River at Marseilles, Ill., between 1981 and 1992 decreased beginning in 1987. A breakdown product of the organochlorine pesticide dichloro-diphenyl-trichloroethane (DDT), p

  17. Inter-organizational relationships of seven Veterans Affairs Medical Centers and their affiliated medical schools: results of a multiple-case-study investigation.

    Science.gov (United States)

    Leeman, J; Kilpatrick, K

    2000-10-01

    This study describes the costs and and value added to Veterans Affairs Medical Centers (VAMCs) through their affiliations with medical schools. The study also creates a conceptual framework for evaluating the critical dimensions across which these affiliations vary. Case studies of seven VAMCs' affiliations with medical schools, ranging from two highly affiliated VAMCs to one with only one funded residency position, were conducted in 1997 and 1998 using a survey and in-depth interviews with 78 key individuals at the institutions. The qualitative data were then used to develop a conceptual framework for evaluating these affiliations. The results are reported in two stages. In stage one, three organizing themes emerged from the data that formed the conceptual framework for evaluating affiliations: (1) the characteristics of each VAMC and its environment, (2) the characteristics of the relationships between each VAMC and its medical school affiliates, and (3) the costs and value that medical school affiliations add to VAMCs. The affiliations that were most beneficial to VAMCs were characterized by a relationship of trust, extensively shared education and research programs, and a high degree of physician interaction. The achievement of these characteristics is influenced by the distance between the VAMCs and their affiliated medical schools, the VAMCs' levels of organizational complexity, the degree of managed care penetration, and the continuity and academic orientation of leadership at the VAMCs. In stage two, study data were used to create a conceptual framework to evaluate the characteristics of VAMCs and their affiliations with medical schools. The study supplied data to construct a conceptual framework that describes many of the relationships among the different affiliations in the study. The framework offers a tool for evaluating the dimensions across which affiliations vary and how these differences influence the costs and value of medical school affiliations

  18. Correlation between genotypic and phenotypic testing for resistance to rifampin in Mycobacterium tuberculosis clinical isolates in Haiti: investigation of cases with discrepant susceptibility results.

    Directory of Open Access Journals (Sweden)

    Oksana Ocheretina

    Full Text Available The World Health Organization has recommended use of molecular-based tests MTBDRplus and GeneXpert MTB/RIF to diagnose multidrug-resistant tuberculosis in developing and high-burden countries. Both tests are based on detection of mutations in the Rifampin (RIF Resistance-Determining Region of DNA-dependent RNA Polymerase gene (rpoB. Such mutations are found in 95-98% of Mycobacterium tuberculosis strains determined to be RIF-resistant by the "gold standard" culture-based drug susceptibility testing (DST. We report the phenotypic and genotypic characterization of 153 consecutive clinical Mycobacterium tuberculosis strains diagnosed as RIF-resistant by molecular tests in our laboratory in Port-au-Prince, Haiti. 133 isolates (86.9% were resistant to both RIF and Isoniazid and 4 isolates (2.6% were RIF mono-resistant in MGIT SIRE liquid culture-based DST. However the remaining 16 isolates (10.5% tested RIF-sensitive by the assay. Five strains with discordant genotypic and phenotypic susceptibility results had RIF minimal inhibitory concentration (MIC close to the cut-off value of 1 µg/ml used in phenotypic susceptibility assays and were confirmed as resistant by DST on solid media. Nine strains had sub-critical RIF MICs ranging from 0.063 to 0.5 µg/ml. Finally two strains were pan-susceptible and harbored a silent rpoB mutation. Our data indicate that not only detection of the presence but also identification of the nature of rpoB mutation is needed to accurately diagnose resistance to RIF in Mycobacterium tuberculosis. Observed clinical significance of low-level resistance to RIF supports the re-evaluation of the present critical concentration of the drug used in culture-based DST assays.

  19. Comparison of Bispectral Index™ values during the flotation restricted environmental stimulation technique and results for stage I sleep: a prospective pilot investigation.

    Science.gov (United States)

    Dunham, C Michael; McClain, Jesse V; Burger, Amanda

    2017-11-29

    To determine whether Bispectral Index™ values obtained during flotation-restricted environment stimulation technique have a similar profile in a single observation compared to literature-derived results found during sleep and other relaxation-induction interventions. Bispectral Index™ values were as follows: awake-state, 96.6; float session-1, 84.3; float session-2, 82.3; relaxation-induction, 82.8; stage I sleep, 86.0; stage II sleep, 66.2; and stages III-IV sleep, 45.1. Awake-state values differed from float session-1 (%difference 12.7%; Cohen's d = 3.6) and float session-2 (%difference 14.8%; Cohen's d = 4.6). Relaxation-induction values were similar to float session-1 (%difference 1.8%; Cohen's d = 0.3) and float session-2 (%difference 0.5%; Cohen's d = 0.1). Stage I sleep values were similar to float session-1 (%difference 1.9%; Cohen's d = 0.4) and float session-2 (%difference 4.3%; Cohen's d = 1.0). Stage II sleep values differed from float session-1 (%difference 21.5%; Cohen's d = 4.3) and float session-2 (%difference 19.6%; Cohen's d = 4.0). Stages III-IV sleep values differed from float session-1 (%difference 46.5%; Cohen's d = 5.6) and float session-2 (%difference 45.2%; Cohen's d = 5.4). Bispectral Index™ values during flotation were comparable to those found in stage I sleep and nadir values described with other relaxation-induction techniques.

  20. Combining laboratory results, numerical modeling, and in situ measurements to investigate the relative contributions of homogeneous and heterogeneous nucleation to ice formation in the tropical tropopause layer

    Science.gov (United States)

    Jensen, E. J.; Karcher, B.; Ueyama, R.; Pfister, L.; Bui, T. V.; Diskin, G. S.; DiGangi, J. P.; Woods, S.; Lawson, P.; Froyd, K. D.; Murphy, D. M.

    2017-12-01

    Laboratory experiments over the past decade have advanced our understanding of the physical state and ice nucleation efficacy of aerosols with atmospherically-relevant compositions at low temperatures. We use these laboratory results along with measurements of upper-tropospheric aerosol composition to develop a parameterization if the ice nuclei number, and activity dependence on ice supersaturation and temperature in the cold tropical tropopause layer (TTL, 13-18 km). We show that leading candidates for aerosol types serving as effective ice nuclei are glassy organic-containing aerosols, crystalline ammonium sulfate, and mineral dust. We apply the low-temperature heterogeneous ice nucleation parameterization in a detailed model of TTL transport and cirrus formation. The model treats heterogeneous ice nucleation and homogeneous freezing of aqueous aerosols, deposition growth and sublimation of ice crystals, and sedimentation of ice crystals. The model is driven by meteorological fields with high-frequency waves superimposed, and simulated cirrus microphysical properties are statistically compared with recent measurements of TTL cirrus microphysical properties and ice supersaturation from recent high-altitude aircraft campaigns. We show that effective ice nuclei concentrations on the order of 50-100/L can dominate over homogeneous freezing production of TTL cirrus ice crystals. Glassy organic-containing aerosols or crystalline ammonium sulfate could conceivably provide more abundant sources of ice nuclei, but the simulations indicate that high concentrations of effective IN would prevent observed occurrence of large supersaturations and high ice concentrations. We will also show the impact of heterogeneous ice nuclei on TTL cirrus microphysical properties and occurrence frequencies.

  1. Should previous mammograms be digitised in the transition to digital mammography?

    International Nuclear Information System (INIS)

    Taylor-Phillips, S.; Gale, A.G.; Wallis, M.G.

    2009-01-01

    Breast screening specificity is improved if previous mammograms are available, which presents a challenge when converting to digital mammography. Two display options were investigated: mounting previous film mammograms on a multiviewer adjacent to the workstation, or digitising them for soft copy display. Eight qualified screen readers were videotaped undertaking routine screen reading for two 45-min sessions in each scenario. Analysis of gross eye and head movements showed that when digitised, previous mammograms were examined a greater number of times per case (p=0.03), due to a combination of being used in 19% more cases (p=0.04) and where used, looked at a greater number of times (28% increase, p=0.04). Digitising previous mammograms reduced both the average time taken per case by 18% (p=0.04) and the participants' perceptions of workload (p < 0.05). Digitising previous analogue mammograms may be advantageous, in particular in increasing their level of use. (orig.)

  2. Should previous mammograms be digitised in the transition to digital mammography?

    Energy Technology Data Exchange (ETDEWEB)

    Taylor-Phillips, S.; Gale, A.G. [Loughborough University, Applied Vision Research Centre, Leicestershire (United Kingdom); Wallis, M.G. [Addenbrooke' s Hospital, Cambridge Breast Unit, Cambridge (United Kingdom)

    2009-08-15

    Breast screening specificity is improved if previous mammograms are available, which presents a challenge when converting to digital mammography. Two display options were investigated: mounting previous film mammograms on a multiviewer adjacent to the workstation, or digitising them for soft copy display. Eight qualified screen readers were videotaped undertaking routine screen reading for two 45-min sessions in each scenario. Analysis of gross eye and head movements showed that when digitised, previous mammograms were examined a greater number of times per case (p=0.03), due to a combination of being used in 19% more cases (p=0.04) and where used, looked at a greater number of times (28% increase, p=0.04). Digitising previous mammograms reduced both the average time taken per case by 18% (p=0.04) and the participants' perceptions of workload (p < 0.05). Digitising previous analogue mammograms may be advantageous, in particular in increasing their level of use. (orig.)

  3. Intelligence, previous convictions and interrogative suggestibility: a path analysis of alleged false-confession cases.

    Science.gov (United States)

    Sharrock, R; Gudjonsson, G H

    1993-05-01

    The main purpose of this study was to investigate the relationship between interrogative suggestibility and previous convictions among 108 defendants in criminal trials, using a path analysis technique. It was hypothesized that previous convictions, which may provide defendants with interrogative experiences, would correlate negatively with 'shift' as measured by the Gudjonsson Suggestibility Scale (Gudjonsson, 1984a), after intelligence and memory had been controlled for. The hypothesis was partially confirmed and the theoretical and practical implications of the findings are discussed.

  4. What Predicts Patients' Willingness to Undergo Online Treatment and Pay for Online Treatment? Results from a Web-Based Survey to Investigate the Changing Patient-Physician Relationship.

    Science.gov (United States)

    Roettl, Johanna; Bidmon, Sonja; Terlutter, Ralf

    2016-02-04

    ), and willingness to communicate with the GP online more often in the future (B=.076, P=.03). Age, gender, and trust in the GP were not significant predictors for either willingness to undergo online treatment or to pay additionally for online treatment. Willingness to undergo online treatment was partly determined by the actual use of online communication with the GP, willingness to communicate online with the GP, health information-seeking personality, and social motivation for such behavior. Willingness to pay extra for online treatment was influenced by the monthly household net income category and education level. The results of this study are useful for online health care providers and physicians who are considering offering online treatments as a viable number of patients would appreciate the possibility of undergoing an online treatment offered by their GP.

  5. 2 CFR 225.45 - Relationship to previous issuance.

    Science.gov (United States)

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Relationship to previous issuance. 225.45 Section 225.45 Grants and Agreements OFFICE OF MANAGEMENT AND BUDGET CIRCULARS AND GUIDANCE Reserved COST PRINCIPLES FOR STATE, LOCAL, AND INDIAN TRIBAL GOVERNMENTS (OMB CIRCULAR A-87) § 225.45 Relationship to...

  6. Cryptococcal meningitis in a previously healthy child | Chimowa ...

    African Journals Online (AJOL)

    An 8-year-old previously healthy female presented with a 3 weeks history of headache, neck stiffness, deafness, fever and vomiting and was diagnosed with cryptococcal meningitis. She had documented hearing loss and was referred to tertiary-level care after treatment with fluconazole did not improve her neurological ...

  7. Rapid fish stock depletion in previously unexploited seamounts: the ...

    African Journals Online (AJOL)

    Rapid fish stock depletion in previously unexploited seamounts: the case of Beryx splendens from the Sierra Leone Rise (Gulf of Guinea) ... A spectral analysis and red-noise spectra procedure (REDFIT) algorithm was used to identify the red-noise spectrum from the gaps in the observed time-series of catch per unit effort by ...

  8. Obstructive pulmonary disease in patients with previous tuberculosis ...

    African Journals Online (AJOL)

    Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort. B.W. Allwood, R Gillespie, M Galperin-Aizenberg, M Bateman, H Olckers, L Taborda-Barata, G.L. Calligaro, Q Said-Hartley, R van Zyl-Smit, C.B. Cooper, E van Rikxoort, J Goldin, N Beyers, E.D. Bateman ...

  9. Balance and bilateral skills of selected previously disadvantaged ...

    African Journals Online (AJOL)

    Balance and bilateral skills of selected previously disadvantaged children aged 9 to 12 years. Eileen K Africa, Karel J Van Deventer. Abstract. The main aim of the study was to design an appropriate motor skills development programme that could be implemented in any primary school to improve the fundamental motor ...

  10. Outcome Of Pregnancy Following A Previous Lower Segment ...

    African Journals Online (AJOL)

    Background: A previous ceasarean section is an important variable that influences patient management in subsequent pregnancies. A trial of vaginal delivery in such patients is a feasible alternative to a secondary section, thus aiding to reduce the ceasarean section rate and its associated co-morbidities. Objective: To ...

  11. Suburethral sling procedures after previous surgery for urinary ...

    African Journals Online (AJOL)

    Objective. To compare the outcome of suburethral sling procedures (tension-free vaginal tape (TVT), obturator tape (Ob-tape)) for stress urinary incontinence (SUI) in women with previous surgery for SUI or pelvic organ prolapse (POP). Methods. A comparative, descriptive, retrospective study was done using information ...

  12. 5 CFR 532.405 - Use of highest previous rate.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Use of highest previous rate. 532.405 Section 532.405 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... rate may be based upon a rate of pay received during a temporary promotion, so long as the temporary...

  13. 24 CFR 1710.552 - Previously accepted state filings.

    Science.gov (United States)

    2010-04-01

    ... of Substantially Equivalent State Law § 1710.552 Previously accepted state filings. (a) Materials... and contracts or agreements contain notice of purchaser's revocation rights. In addition see § 1715.15..., unless the developer is obligated to do so in the contract. (b) If any such filing becomes inactive or...

  14. 5 CFR 9701.352 - Use of highest previous rate.

    Science.gov (United States)

    2010-01-01

    ... HUMAN RESOURCES MANAGEMENT SYSTEM Pay and Pay Administration Pay Administration § 9701.352 Use of... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Use of highest previous rate. 9701.352 Section 9701.352 Administrative Personnel DEPARTMENT OF HOMELAND SECURITY HUMAN RESOURCES MANAGEMENT...

  15. Bilateral orbital infarction and retinal detachment in a previously ...

    African Journals Online (AJOL)

    In this report, we present a case of an 11‑year‑old previously undiagnosed sickle cell disease Nigerian girl with severe acute bilateral orbital infarction and retinal detachment to highlight that hemoglobinopathy induced orbital infarction should be considered in African children with acute onset proptosis with or without ...

  16. Response to health insurance by previously uninsured rural children.

    Science.gov (United States)

    Tilford, J M; Robbins, J M; Shema, S J; Farmer, F L

    1999-08-01

    To examine the healthcare utilization and costs of previously uninsured rural children. Four years of claims data from a school-based health insurance program located in the Mississippi Delta. All children who were not Medicaid-eligible or were uninsured, were eligible for limited benefits under the program. The 1987 National Medical Expenditure Survey (NMES) was used to compare utilization of services. The study represents a natural experiment in the provision of insurance benefits to a previously uninsured population. Premiums for the claims cost were set with little or no information on expected use of services. Claims from the insurer were used to form a panel data set. Mixed model logistic and linear regressions were estimated to determine the response to insurance for several categories of health services. The use of services increased over time and approached the level of utilization in the NMES. Conditional medical expenditures also increased over time. Actuarial estimates of claims cost greatly exceeded actual claims cost. The provision of a limited medical, dental, and optical benefit package cost approximately $20-$24 per member per month in claims paid. An important uncertainty in providing health insurance to previously uninsured populations is whether a pent-up demand exists for health services. Evidence of a pent-up demand for medical services was not supported in this study of rural school-age children. States considering partnerships with private insurers to implement the State Children's Health Insurance Program could lower premium costs by assembling basic data on previously uninsured children.

  17. "Battered Women" and Previous Victimization: Is the Question Relevant?

    Science.gov (United States)

    Gudim, Laurie, Comp.; And Others

    This report discusses battered women and the role of their previous victimization. After a literature review on family violence in general, these topics are discussed: (1) family violence and the patriarchy; (2) the historical background of family violence; (3) intergenerational cycle of violence; and (4) psychological literature's four ways…

  18. Choice of contraception after previous operative delivery at a family ...

    African Journals Online (AJOL)

    Age, education, religion, parity, prior contraception, and interval from the last delivery were significantly associated with the current choice of contraception (P 0.05). Overall, when comparing the pattern among those with a previous operative delivery and those without, ...

  19. Process cells dismantling of EUREX pant: previous activities

    International Nuclear Information System (INIS)

    Gili, M.

    1998-01-01

    In the '98-'99 period some process cells of the EUREX pant will be dismantled, in order to place there the liquid wastes conditioning plant 'CORA'. This report resumes the previous activities (plant rinsing campaigns and inactive Cell 014 dismantling), run in the past three years and the drawn experience [it

  20. The job satisfaction of principals of previously disadvantaged schools

    African Journals Online (AJOL)

    The aim of this study was to identify influences on the job satisfaction of previously disadvantaged school principals in North-West Province. Evans's theory of job satisfaction, morale and motivation was useful as a conceptual framework. A mixedmethods explanatory research design was important in discovering issues with ...

  1. Previous utilization of service does not improve timely booking in ...

    African Journals Online (AJOL)

    Previous utilization of service does not improve timely booking in antenatal care: Cross sectional study on timing of antenatal care booking at public health facilities in ... Methods: A cross sectional study was conducted to collect data from 630 pregnant women who were attending antenatal care service at 10 governmental ...

  2. Mondor's Disease of the Breast in a Nigerian Woman Previously ...

    African Journals Online (AJOL)

    2017-09-14

    Sep 14, 2017 ... Case Report. How to cite this article: Olarinoye-Akorede SA, Silas BT. Mondor's disease of the breast in a Nigerian woman previously treated for invasive ductal carcinoma in the ... and the new creations are licensed under the identical terms. For reprints .... malignancy. Financial support and sponsorship.

  3. 44 CFR 402.5 - Forwarding commodities previously shipped.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Forwarding commodities... commodities previously shipped. Order T-1 applies to transportation on or discharge from ships documented... ship or aircraft, before the issuance of Order T-1, had transported restricted commodities manifested...

  4. Nitrogen rate and previous crop effects on some agronomic traits of ...

    African Journals Online (AJOL)

    There was a previous crop x N rate interaction for seed yield during both years while significant previous crop x N rate interactions were determined for 1000 seed weight and seed weight of each ear in 2005. This study suggested that N rates and corn cultivars might result significant differences on tasseling period, ear silk ...

  5. Reoperative sentinel lymph node biopsy after previous mastectomy.

    Science.gov (United States)

    Karam, Amer; Stempel, Michelle; Cody, Hiram S; Port, Elisa R

    2008-10-01

    Sentinel lymph node (SLN) biopsy is the standard of care for axillary staging in breast cancer, but many clinical scenarios questioning the validity of SLN biopsy remain. Here we describe our experience with reoperative-SLN (re-SLN) biopsy after previous mastectomy. Review of the SLN database from September 1996 to December 2007 yielded 20 procedures done in the setting of previous mastectomy. SLN biopsy was performed using radioisotope with or without blue dye injection superior to the mastectomy incision, in the skin flap in all patients. In 17 of 20 patients (85%), re-SLN biopsy was performed for local or regional recurrence after mastectomy. Re-SLN biopsy was successful in 13 of 20 patients (65%) after previous mastectomy. Of the 13 patients, 2 had positive re-SLN, and completion axillary dissection was performed, with 1 having additional positive nodes. In the 11 patients with negative re-SLN, 2 patients underwent completion axillary dissection demonstrating additional negative nodes. One patient with a negative re-SLN experienced chest wall recurrence combined with axillary recurrence 11 months after re-SLN biopsy. All others remained free of local or axillary recurrence. Re-SLN biopsy was unsuccessful in 7 of 20 patients (35%). In three of seven patients, axillary dissection was performed, yielding positive nodes in two of the three. The remaining four of seven patients all had previous modified radical mastectomy, so underwent no additional axillary surgery. In this small series, re-SLN was successful after previous mastectomy, and this procedure may play some role when axillary staging is warranted after mastectomy.

  6. The Effect of Single Versus Repeated Previous Strategy Use on Individuals' Subsequent Strategy Choice

    Directory of Open Access Journals (Sweden)

    Viki Schillemans

    2012-12-01

    Full Text Available Previous research has shown that participants' strategy choices can be influenced by the previously-used strategy. This'perseveration effect' has been demonstrated both after a repeated use of the previous strategy (e.g., Schillemans, Luwel, Bulté, Onghena, & Verschaffel, 2009, but also after a single use of the previous strategy (Lemaire & Lecacheur, 2010. In the present study, we tested whether this perseveration effect would be stronger after a repeated than after a single previous strategy application. We were able to replicate the perseveration effect but we did not find evidence for an influence of the number of previous strategy applications on the strength of this effect. An additional cluster analysis revealed that only about one third of the participants was susceptible for the perseveration effect. The theoretical, methodological, and educational implications of these results are discussed.

  7. Results from Marine geological investigations outside Forsmark

    International Nuclear Information System (INIS)

    Nyberg, Johan; Elhammer, Anders; Sohlenius, Gustav; Kjellin, Bernt; Nordgren, Paer

    2011-08-01

    A detailed marine geological survey was conducted in a 10 km 2 large area outside Forsmark comprising hydro acoustic, 100 m spacing between survey lines, and groundtruthing. These data, together with reanalyzed survey data retrieved in 2002 from the same area, were used to produce maps of seabed and underlying bedrock surface morphology as well as horizontal and vertical extension of sediments. An esker is discovered running approximately in a north northwesterly-south southeasterly direction in the area, which may be causing submarine groundwater discharge. Pockmarks, which are caused by sediment gas of thermogenic and/or microbial origin, are detected in the area. In addition to the original commissioned survey, bedrock surface and seabed morphology as well as horizontal and vertical extension of sediments in a larger adjacent area were reanalyzed and produced from survey lines retrieved during a commission by SKB in 2002 and during SGUs regular mapping program in 2002, 2008 and 2009

  8. Results from Marine geological investigations outside Forsmark

    Energy Technology Data Exchange (ETDEWEB)

    Nyberg, Johan; Elhammer, Anders; Sohlenius, Gustav; Kjellin, Bernt; Nordgren, Paer (Geological Survey of Sweden (Sweden))

    2011-08-15

    A detailed marine geological survey was conducted in a 10 km2 large area outside Forsmark comprising hydro acoustic, 100 m spacing between survey lines, and groundtruthing. These data, together with reanalyzed survey data retrieved in 2002 from the same area, were used to produce maps of seabed and underlying bedrock surface morphology as well as horizontal and vertical extension of sediments. An esker is discovered running approximately in a north northwesterly-south southeasterly direction in the area, which may be causing submarine groundwater discharge. Pockmarks, which are caused by sediment gas of thermogenic and/or microbial origin, are detected in the area. In addition to the original commissioned survey, bedrock surface and seabed morphology as well as horizontal and vertical extension of sediments in a larger adjacent area were reanalyzed and produced from survey lines retrieved during a commission by SKB in 2002 and during SGUs regular mapping program in 2002, 2008 and 2009

  9. Previously unreported abnormalities in Wolfram Syndrome Type 2.

    Science.gov (United States)

    Akturk, Halis Kaan; Yasa, Seda

    2017-01-01

    Wolfram syndrome (WFS) is a rare autosomal recessive disease with non-autoimmune childhood onset insulin dependent diabetes and optic atrophy. WFS type 2 (WFS2) differs from WFS type 1 (WFS1) with upper intestinal ulcers, bleeding tendency and the lack ofdiabetes insipidus. Li-fespan is short due to related comorbidities. Only a few familieshave been reported with this syndrome with the CISD2 mutation. Here we report two siblings with a clinical diagnosis of WFS2, previously misdiagnosed with type 1 diabetes mellitus and diabetic retinopathy-related blindness. We report possible additional clinical and laboratory findings that have not been pre-viously reported, such as asymptomatic hypoparathyroidism, osteomalacia, growth hormone (GH) deficiency and hepatomegaly. Even though not a requirement for the diagnosis of WFS2 currently, our case series confirm hypogonadotropic hypogonadism to be also a feature of this syndrome, as reported before. © Polish Society for Pediatric Endocrinology and Diabetology.

  10. Nicotine Elicits Methamphetamine-Seeking in Rats Previously Administered Nicotine

    OpenAIRE

    Neugebauer, N. M.; Harrod, S. B.; Bardo, M. T.

    2009-01-01

    Research has indicated a high correlation between psychostimulant use and tobacco cigarette smoking in human substance abusers. The objective of the current study was to examine the effects of acute and repeated nicotine administration on responding for intravenous methampheta