Magnetic field induced flow pattern reversal in a ferrofluidic Taylor-Couette system.

Science.gov (United States)

Altmeyer, Sebastian; Do, Younghae; Lai, Ying-Cheng

2015-12-21

We investigate the dynamics of ferrofluidic wavy vortex flows in the counter-rotating Taylor-Couette system, with a focus on wavy flows with a mixture of the dominant azimuthal modes. Without external magnetic field flows are stable and pro-grade with respect to the rotation of the inner cylinder. More complex behaviors can arise when an axial or a transverse magnetic field is applied. Depending on the direction and strength of the field, multi-stable wavy states and bifurcations can occur. We uncover the phenomenon of flow pattern reversal as the strength of the magnetic field is increased through a critical value. In between the regimes of pro-grade and retrograde flow rotations, standing waves with zero angular velocities can emerge. A striking finding is that, under a transverse magnetic field, a second reversal in the flow pattern direction can occur, where the flow pattern evolves into pro-grade rotation again from a retrograde state. Flow reversal is relevant to intriguing phenomena in nature such as geomagnetic reversal. Our results suggest that, in ferrofluids, flow pattern reversal can be induced by varying a magnetic field in a controlled manner, which can be realized in laboratory experiments with potential applications in the development of modern fluid devices.

Transition of unsteady velocity profiles with reverse flow

OpenAIRE

Das, Debopam; Arakeri, Jaywant H

1998-01-01

This paper deals with the stability and transition to turbulence of wall-bounded unsteady velocity profiles with reverse flow. Such flows occur, for example, during unsteady boundary layer separation and in oscillating pipe flow. The main focus is on results from experiments in time-developing flow in a long pipe, which is decelerated rapidly. The flow is generated by the controlled motion of a piston. We obtain analytical solutions for laminar flow in the pipe and in a two-dimensional channe...

Performance characteristics of plane-wall venturi-like reverse flow diverters

International Nuclear Information System (INIS)

Smith, G.V.; Counce, R.M.

1982-01-01

The results of an analytical and experimental study of plane-wall venturi-like reverse flow diverters (RFD) are presented. In general, the flow characteristics of the RFD are reasonably well predicted by the mathematical model of the RFD, although a divergence between theory and data is observed for the output characteristics in the reverse flow mode as the output impedance is reduced. Overall, the performance of these devices indicates their usefulness in fluid control and fluid power systems, such as displacement pumping systems

Reversing flow causes passive shark scale actuation in a separating turbulent boundary layer

Science.gov (United States)

Lang, Amy; Gemmell, Bradford; Motta, Phil; Habegger, Laura; Du Clos, Kevin; Devey, Sean; Stanley, Caleb; Santos, Leo

2017-11-01

Control of flow separation by shortfin mako skin in experiments has been demonstrated, but the mechanism is still poorly understood yet must be to some extent Re independent. The hypothesized mechanisms inherent in the shark skin for controlling flow separation are: (1) the scales, which are capable of being bristled only by reversing flow, inhibit flow reversal events from further development into larger-scale separation and (2) the cavities formed when scales bristle induces mixing of high momentum flow towards the wall thus energizing the flow close to the surface. Two studies were carried out to measure passive scale actuation caused by reversing flow. A small flow channel induced an unsteady, wake flow over the scales prompting reversing flow events and scale actuation. To resolve the flow and scale movements simultaneously we used specialized optics at high magnification (1 mm field of view) at 50,000 fps. In another study, 3D printed models of shark scales, or microflaps (bristling capability up to 50 degrees), were set into a flat plate. Using a tripped, turbulent boundary layer grown over the long flat plate and a localized adverse pressure gradient, a separation bubble was generated within which the microflaps were placed. Passive flow actuation of both shark scales and microflaps by reversing flow was observed. Funding from Army Research Office and NSF REU site Grant.

Cluster observation of plasma flow reversal in the magnetotail during a substorm

Directory of Open Access Journals (Sweden)

A. T. Y. Lui

2006-08-01

Full Text Available We investigate in detail a reversal of plasma flow from tailward to earthward detected by Cluster at the downstream distance of ~19 RE in the midnight sector of the magnetotail on 22 August 2001. This flow reversal was accompanied by a sign reversal of the Bz component and occurred during the late substorm expansion phase as revealed by simultaneous global view of auroral activity from IMAGE. We examine the associated Hall current system signature, current density, electric field, Lorentz force, and current dissipation/dynamo term, the last two parameters being new features that have not been studied previously for plasma flow reversals. It is found that (1 there was no clear quadrupole Hall current system signature organized by the flow reversal time, (2 the x-component of the Lorentz force did not change sign while the other two did, (3 the timing sequence of flow reversal from the Cluster configuration did not match tailward motion of a single plasma flow source, (4 the electric field was occasionally dawnward, producing a dynamo effect, and (5 the electric field was occasionally larger at the high-latitude plasma sheet than near the neutral sheet. These observations are consistent with the current disruption model for substorms in which these disturbances are due to shifting dominance of multiple current disruption sites and turbulence at the observing location.

Remagnetization of lava flows spanning the last geomagnetic reversal

Science.gov (United States)

Vella, Jérôme; Carlut, Julie; Valet, Jean-Pierre; Goff, Maxime Le; Soler, Vicente; Lopes, Fernando

2017-08-01

Large directional changes of remanent magnetization within lava flows that cooled during geomagnetic reversals have been reported in several studies. A geomagnetic scenario implies extremely rapid geomagnetic changes of several degrees per day, thus difficult to reconcile with the rate of the earth's core liquid motions. So far, no complete rock magnetic model provides a clear explanation. We revisited lava flows sandwiched between an underlying reverse and an overlying normal polarity flow marking the last reversal in three distinct volcanic sequences of the La Palma Island (Canary archipelago, Spain) that are characterized by a gradual evolution of the direction of their remanent magnetization from bottom to top. Cleaning efficiency of thermal demagnetization was not improved by very rapid heating and cooling rates as well as by continuous demagnetization using a Triaxe magnetometer. We did not observe partial self-reversals and minor changes in magnetic grain sizes are not related to the within-flow directional changes. Microscopic observations indicate poor exsolution, which suggests post-cooling thermochemical remagnetization processes. This scenario is strongly reinforced by laboratory experiments that show large resistance to thermal demagnetization when thermoremanence was acquired over a long time period. We speculate that in the present situation exsolution was reactivated during in field reheating and yielded formation of new magnetite, yet magnetic domain state rearrangements could also play a role. Initial reheating when the overlying flow took place, albeit moderate (less than 200-300 °C), was enough to produce overlying components with significantly higher unblocking temperatures.

Analysis of reverse flow in inverted U-tubes of steam generator under natural circulation condition

International Nuclear Information System (INIS)

Yang Ruichang; Liu Ruolei; Liu Jinggong; Qin Shiwei

2008-01-01

In this paper, we report on the analysis of reverse flow in inverted U-tubes of a steam generator under natural circulation condition. The mechanism of reverse flow in inverted U-tubes of the steam generator with natural circulation is graphically analyzed by using the full-range characteristic curve of parallel U-tubes. The mathematical model and numerical calculation method for analyzing the reverse flow in inverted U-tubes of the steam generator with natural circulation have been developed. The reverse flow in an inverted U-tube steam generator of a simulated pressurized water reactor with natural circulation in analyzed. Through the calculation, the mass flow rates of normal and reverse flows in individual U-tubes are obtained. The predicted sharp drop of the fluid temperature in the inlet plenum of the steam generator due to reverse flow agrees very well with the experimental data. This indicates that the developed mathematical model and solution method can be used to correctly predict the reverse flow in the inverted U-tubes of the steam generator with natural circulation. The obtained results also show that in the analysis of natural circulation flow in the primary circuit, the reverse flow in the inverted U-tubes of the steam generator must be taken into account. (author)

Reverse flow operation with reactor side feeding : analysis, modeling and simulation

NARCIS (Netherlands)

Budhi, Y.W.; Hoebink, J.H.B.J.; Schouten, J.C.

2004-01-01

The novel concept of reverse flow operation with reactor side feeding is studied for selective oxidation of NH3 to produce either N2, N2O, or NO. During normal reverse flow operation, where the feeds are alternately introduced from either end of the reactor, the conversion is always lower when

Cluster observation of plasma flow reversal in the magnetotail during a substorm

Directory of Open Access Journals (Sweden)

A. T. Y. Lui

2006-08-01

Full Text Available We investigate in detail a reversal of plasma flow from tailward to earthward detected by Cluster at the downstream distance of ~19 R_E in the midnight sector of the magnetotail on 22 August 2001. This flow reversal was accompanied by a sign reversal of the B_z component and occurred during the late substorm expansion phase as revealed by simultaneous global view of auroral activity from IMAGE. We examine the associated Hall current system signature, current density, electric field, Lorentz force, and current dissipation/dynamo term, the last two parameters being new features that have not been studied previously for plasma flow reversals. It is found that (1 there was no clear quadrupole Hall current system signature organized by the flow reversal time, (2 the x-component of the Lorentz force did not change sign while the other two did, (3 the timing sequence of flow reversal from the Cluster configuration did not match tailward motion of a single plasma flow source, (4 the electric field was occasionally dawnward, producing a dynamo effect, and (5 the electric field was occasionally larger at the high-latitude plasma sheet than near the neutral sheet. These observations are consistent with the current disruption model for substorms in which these disturbances are due to shifting dominance of multiple current disruption sites and turbulence at the observing location.

An analytic model for flow reversal in divertor plasmas

International Nuclear Information System (INIS)

Cooke, P.I.H.; Prinja, A.K.

1987-04-01

An analytic model is developed and used to study the phenomenon of flow reversal which is observed in two-dimensional simulations of divertor plasmas. The effect is shown to be caused by the radial spread of neutral particles emitted from the divertor target which can lead to a strong peaking of the ionization source at certain radial locations. The results indicate that flow reversal over a portion of the width of the scrape-off layer is inevitable in high recycling conditions. Implications for impurity transport and particle removal in reactors are discussed

Experimental study of a reverse flow catalytic converter for a duel fuel engine

Energy Technology Data Exchange (ETDEWEB)

Liu, B.; Checkel, M. D. [Alberta Univ., Dept. of Mechanical Engineering, Edmonton, ANB (Canada); Hayes, R. E. [Alberta Univ., Dept, of Chemical and Materials Engineering, Edmonton, AB, (Canada)

2001-08-01

Performance of a reverse flow catalytic converter for a methane/diesel dual fuel engine is evaluated under steady and transient engine conditions. The converter is of the monolith honeycomb type with palladium catalyst washcoat. Results of the reverse flow converter's performance was found to be superior for several steady state engine operations when compared to unidirectional flow operation. In transient operations following a step change in engine operating conditions, reverse flow was found to be better than unidirectional flow when the change in engine operation was such as to reduce the exhaust gas temperature. When exhaust gas temperature was increased, reverse flow decreased the rate of increase in the reactor temperature. Testing was done using the transient Japanese 6-Mode tests. Best results were achieved with a switch time in the five seconds to fifteen seconds range. 31 refs., 9 tabs., 24 figs.

Modified and reverse radiometric flow injection analysis

Energy Technology Data Exchange (ETDEWEB)

Myint, U; Ba, H; Khin, M M; Aung, K; Thida, [Yangon Univ. (Myanmar). Dept. of Chemistry; Toelgyessy, J [Slovak Technical Univ., Bratislava (Slovakia). Dept. of Environmental Science

1994-06-01

Determination of [sup 137]Cs and [sup 60]Co by using modified and reverse radiometric flow injection analysis is described. Two component RFIA was also realized using [sup 60]Co and [sup 137]Cs radionuclides. (author) 2 refs.; 5 figs.

Calculation of reverse flow in inverted U-Tubes of steam generator during natural circulation

International Nuclear Information System (INIS)

Yang Ruichang; Liu Jinggong; Liu Ruolei; Qin Shiwei; Huang Yanping

2010-01-01

The mechanism of reverse flow in inverted U-tubes of steam generators of pressurized water reactors during natural circulation is analyzed by using the full range characteristic curve of parallel U-tubes. A lumped-distributed model to calculate the reverse flow occurred in inverted U-tubes of real steam generators with a large number of U-tubes during natural circulation is developed. The model has the advantages of quick calculation and high accuracy for the analysis of reverse flow in inverted U-tubes of real steam generators with natural circulation. This model has been used to calculate the normal and reverse flows occurred in inverted U-tubes of a steam generator with natural circulation. The comparison of calculated results indicates a well agreement with that predicted by the model in which normal or reverse flow in each individual U-tube is analyzed, which verifies the reliability of the model developed in this paper. (authors)

Study on reverse flow characteristics under natural circulation in inverted U-tube steam generator

International Nuclear Information System (INIS)

Duan Jun; Zhou Tao; Zhang Lei; Hong Dexun; Liu Ping

2013-01-01

Natural circulation is important for application in the nuclear power industry. Aiming at the steam generator of AP1000 pressurized water reactor loop, the mathematical model was established to analysis the reverse flow of single-phase water in the inverted U-tubes of a steam generator in a natural circulation system. The length distribution and the mass flow rates in both tubes with normal and reverse flow were determined respectively. The research results show that the reverse flow may result in sharp decrease of gravity pressure head, circulation mass flow rate and heat release rate of natural circulation. It has adverse influence on natural circulation. (authors)

Characterization of Rare Reverse Flow Events in Adverse Pressure Gradient Turbulent Boundary Layers

Science.gov (United States)

Kaehler, Christian J.; Bross, Matthew; Fuchs, Thomas

2017-11-01

Time-resolved tomographic flow fields measured in the viscous sublayer region of a turbulent boundary layer subjected to an adverse pressure gradient (APG) are examined with the aim to resolve and characterize reverse flow events at Reτ = 5000. The fields were measured using a novel high resolution tomographic particle tracking technique. It is shown that this technique is able to fully resolve mean and time dependent features of the complex three-dimensional flow with high accuracy down to very near-wall distances ( 10 μm). From time resolved Lagrangian particle trajectories, statistical information as well as instantaneous topological features of near-wall flow events are deduced. Similar to the zero pressure gradient case (ZPG), it was found that individual events with reverse flow components still occur relatively rarely under the action of the pressure gradient investigated here. However, reverse flow events comprised of many individual events, are shown to appear in relatively organized groupings in both spanwise and streamise directions. Furthermore, instantaneous measurements of reverse flow events show that these events are associated with the motion of low-momentum streaks in the near-wall region. This work is supported by the Priority Programme SPP 1881 Turbulent Superstructures and the individual project Grant KA1808/8-2 of the Deutsche Forschungsgemeinschaft.

Reverse flow and vortex breakdown in a shear-thinning fluid

International Nuclear Information System (INIS)

Cabeza, C; Sarasua, G; Barrere, N; Marti, A C

2011-01-01

The effect of polymer concentration on the development of reverse secondary flow and vortex breakdown was studied using a viscoelastic solution of polyacrlylamide in water. The fluid was contained in cylindrical containers of two different radii, the top end wall of which rotated at a varying speed, thus, imparting a circulating motion to the fluid. Whereas using a newtonian fluid, streamlines will occupy the entire container, the flow of a shear-thinning fluid may divide into two cells of opposite circulating motion. The curve of critical Reynolds and elasticity numbers (Re, E) values corresponding to the development of reverse flow was obtained over a wide range of Re values. Vortex breakdown was found to occur at extremely low Re values.

Mechanism of flow reversal during solidification of an anomalous liquid

Science.gov (United States)

Kumar, Virkeshwar; Kumawat, Mitesh; Srivastava, Atul; Karagadde, Shyamprasad

2017-12-01

In a wide variety of fluidic systems involving thermal and compositional gradients, local density changes lead to the onset of natural convection that influences the process itself, for example, during phase-change phenomena and magmatic flows. Accurate knowledge of the flow characteristics is essential to quantify the impact of the flow of the processes. In this work, the first-ever demonstration of flow reversal during bottom-up solidification of water using full-field thermal and flow measurements and its direct impact on the solidifying interface is presented. Based on prior optical interferometric measurements of full-field temperature distribution in water during solidification, we use the particle image velocimetry technique to quantify and reveal the changing natural convection pattern arising solely due to the density anomaly of water between 0 °C and 4 °C. The independently captured thermal and flow fields show striking similarities and clearly elucidate the plausible mechanism explaining the formation of a curved interface at the stagnation point and the subsequent reversal of flow direction due to a changed interface morphology. A control volume analysis is further presented to estimate the energy invested in the formation of a perturbation and the resulting flip in the flow direction caused by this perturbation.

Reverse flow through a large scale multichannel nozzle

International Nuclear Information System (INIS)

Duignan, M.R.; Nash, C.A.

1992-01-01

A database was developed for the flow of water through a scaled nozzle of a Savannah River Site reactor inlet plenum. The water flow in the nozzle was such that it ranged from stratified to water solid conditions. Data on the entry of air into the nozzle and plenum as a function of water flow are of interest in loss-of-coolant studies. The scaled nozzle was 44 cm long, had an entrance diameter of 95 mm, an exit opening of 58 mm x 356 mm, and an exit hydraulic diameter approximately equal to that of the inlet. Within the nozzle were three flow-straightening vanes which divided the flow path into four channels. All data were taken at steady-state and isothermal (300 K ± 1.5 K) conditions. During the reverse flow of water through the nozzle the point at which air begins to enter was predicted within 90% by a critical weir-flow calculation. The point of air entry into the plenum itself was found to be a function of flow conditions

Buoyancy-driven flow excursions in fuel assemblies

International Nuclear Information System (INIS)

Laurinat, J.E.; Paul, P.K.; Menna, J.D.

1995-01-01

A power limit criterion was developed for a postulated Loss of Pumping Accident (LOPA) in one of the recently shut down heavy water production reactors at the Savannah River Site. These reactors were cooled by recirculating moderator downward through channels in cylindrical fuel tubes. Powers were limited to prevent a flow excursion from occurring in one or more of these parallel channels. During full-power operation, limits prevented a boiling flow excursion from taking place. At low flow rates, during the addition of emergency cooling water, buoyant forces reverse the flow in one of the coolant channels before boiling occurs. As power increases beyond the point of flow reversal, the maximum wall temperature approaches the fluid saturation temperature, and a thermal excursion occurs. The power limit criterion for low flow rates was the onset of flow reversal. To determine conditions for flow reversal, tests were performed in a mock-up of a fuel assembly that contained two electrically heated concentric tubes surrounded by three flow channels. These tests were modeled using a finite difference thermal-hydraulic code. According to code calculations, flow reversed in the outer flow channel before the maximum wall temperature reached the local fluid saturation temperature. Thermal excursions occurred when the maximum wall temperature approximately equaled the saturation temperature. For a postulated LOPA, the flow reversal criterion for emergency cooling water addition was more limiting than the boiling excursion criterion for full power operation. This criterion limited powers to 37% of historical levels

Theory of field-reversed mirrors and field-reversed plasma-gun experiments. Paper IAEA-CN-38/R-2

International Nuclear Information System (INIS)

Anderson, D.V.; Auerbach, S.P.; Berk, H.L.

1980-01-01

Experimental and theoretical studies of field reversal in a mirror machine are reported. Plasma-gun experiments demonstrate that reversed-field plasma layers are formed. Low energy plasma flowing behind the initially produced plasma front prevents tearing of the layer from the gun muzzle. MHD simulation shows that tearing can be obtained by impeding the slow plasma flow with a plasma divider. It is demonstrated theoretically that a field-reversed mirror imbedded in a multipole field can be sustained in steady state with neutral-beam injection even in the absence of impurities. MHD stability analysis shows that growth rates of elongated reversed-field theta-pinch configurations decrease with axial extension, which indicates the importance of including finite Larmor radius in the analysis. Tilting-mode criteria are improved by proper shaping, and a problimak shape is proposed. Tearing mode stability of reversed-field theta-pinches is greatly enhanced by flux exclusion. Self-consistent, 1-1/2-dimensional transport codes have been developed, and initial results are presented

Theory of field-reversed mirrors and field-reversed plasma-gun experiments. Paper IAEA-CN-38/R-2

International Nuclear Information System (INIS)

Anderson, D.V.; Auerbach, S.P.; Berk, H.L.

1980-01-01

Experimental and theoretical studies of field reversal in a mirror machine are reported. Plasma-gun experiments demonstrate that reversed-field plasma layers are formed. Low energy plasma flowing behind the initially produced plasma front prevents tearing of the layer from the gun muzzle. MHD simulation shows that tearing can be obtained by impeding the slow plasma flow with a plasma divider. It is demonstrated theoretically that a field-reversed mirror imbedded in a multipole field can be sustained in steady state with neutral-beam injection even in the absence of impurities. MHD stability analysis shows that growth rates of elongated reversed-field theta-pinch configurations decrease with axial extension, which indicates the importance of including finite Larmor radius in the analysis. Tilting-mode criteria are dramatically improved by proper shaping, and a problimak shape is proposed. Tearing mode stability of reversed-field theta-pinches is greatly enhanced by flux exclusion. Self-consistent, 1-1/2-dimensional transport codes have been developed, and initial results are presented

Reverse-Tangent Injection in a Centrifugal Compressor

Science.gov (United States)

Skoch, Gary J.

2007-01-01

Injection of working fluid into a centrifugal compressor in the reverse tangent direction has been invented as a way of preventing flow instabilities (stall and surge) or restoring stability when stall or surge has already commenced. The invention applies, in particular, to a centrifugal compressor, the diffuser of which contains vanes that divide the flow into channels oriented partly radially and partly tangentially. In reverse-tangent injection, a stream or jet of the working fluid (the fluid that is compressed) is injected into the vaneless annular region between the blades of the impeller and the vanes of the diffuser. As used here, "reverse" signifies that the injected flow opposes (and thereby reduces) the tangential component of the velocity of the impeller discharge. At the same time, the injected jet acts to increase the radial component of the velocity of the impeller discharge.

Reducing the memory requirement in reverse mode automatic differentiation by solving TBR flow equations

International Nuclear Information System (INIS)

Naumann, U.

2002-01-01

The fast computation of gradients in reverse mode Automatic Differentiation (AD) requires the generation of adjoint versions of every statement in the original code. Due to the resulting reversal of the control flow certain intermediate values have to be made available in reverse order to compute the local partial derivatives. This can be achieved by storing these values or by recomputing them when they become required. In any case one is interested in minimizing the size of this set. Following an extensive introduction of the ''To-Be-Recorded'' (TBR) problem the authors present flow equations for propagating the TBR status of variables in the context of reverse mode AD of structured programs

Aortic Blood Flow Reversal Determines Renal Function: Potential Explanation for Renal Dysfunction Caused by Aortic Stiffening in Hypertension.

Science.gov (United States)

Hashimoto, Junichiro; Ito, Sadayoshi

2015-07-01

Aortic stiffness determines the glomerular filtration rate (GFR) and predicts the progressive decline of the GFR. However, the underlying pathophysiological mechanism remains obscure. Recent evidence has shown a close link between aortic stiffness and the bidirectional (systolic forward and early diastolic reverse) flow characteristics. We hypothesized that the aortic stiffening-induced renal dysfunction is attributable to altered central flow dynamics. In 222 patients with hypertension, Doppler velocity waveforms were recorded at the proximal descending aorta to calculate the reverse/forward flow ratio. Tonometric waveforms were recorded to measure the carotid-femoral (aortic) and carotid-radial (peripheral) pulse wave velocities, to estimate the aortic pressure from the radial waveforms, and to compute the aortic characteristic impedance. In addition, renal hemodynamics was evaluated by duplex ultrasound. The estimated GFR was inversely correlated with the aortic pulse wave velocity, reverse/forward flow ratio, pulse pressure, and characteristic impedance, whereas it was not correlated with the peripheral pulse wave velocity or mean arterial pressure. The association between aortic pulse wave velocity and estimated GFR was independent of age, diabetes mellitus, hypercholesterolemia, and antihypertensive medication. However, further adjustment for the aortic reverse/forward flow ratio and pulse pressure substantially weakened this association, and instead, the reverse/forward flow ratio emerged as the strongest determinant of estimated GFR (P=0.001). A higher aortic reverse/forward flow ratio was also associated with lower intrarenal forward flow velocities. These results suggest that an increase in aortic flow reversal (ie, retrograde flow from the descending thoracic aorta toward the aortic arch), caused by aortic stiffening and impedance mismatch, reduces antegrade flow into the kidney and thereby deteriorates renal function. © 2015 American Heart Association

Reversal of flow in the inferior vena cava and hepatic veins on dynamic CT

International Nuclear Information System (INIS)

Lelij, H. van der; Mallens, W.M.C.

1988-01-01

A tricuspid insufficiency may not be clinically evident and may remain unknown to the clinician. The phenomenon of a reversal of inferior vena caval blood flow and hepatic veins is known to occur in tricuspid regurgitation from right ventricular angiography and duplex scanning. Demonstration of such a reversal flow on a dynamic CT scan, as in our case, has, to our knowledge, not as yet been reported

Determination of maximum reactor power level consistent with the requirement that flow reversal occurs without fuel damage

International Nuclear Information System (INIS)

Rao, D.V.; Darby, J.L.; Ross, S.B.; Clark, R.A.

1990-01-01

The High Flux Beam Reactor (HFBR) operated by Brookhaven National Laboratory (BNL) employs forced downflow for heat removal during normal operation. In the event of total loss of forced flow, the reactor will shutdown and the flow reversal valves open. When the downward core flow becomes sufficiently small then the opposing thermal buoyancy induces flow reversal leading to decay heat removal by natural convection. There is some uncertainty as to whether the natural circulation is adequate for decay heat removal after 60 MW operation. BNL- staff carried out a series of calculations to establish the adequacy of flow reversal to remove decay heat. Their calculations are based on a natural convective CHF model. The primary purpose of the present calculations is to review the accuracy and applicability of Fauske's CHF model for the HFBR, and the assumptions and methodology employed by BNL-staff to determine the heat removal limit in the HFBR during a flow reversal and natural convection situation

Occurrence of critical heat flux during blowdown with flow reversal

International Nuclear Information System (INIS)

Leung, J.C.M.

1976-04-01

A small-scale experiment using Freon-11 at 130 0 F and 65 psia in a well-instrumented transparent annular test section was used to study the occurrence of critical heat flux (CHF) during blowdown with flow reversal. The inner stainless steel tube of the annulus was uniformly heated over its 2 ft length. Inlet and exit void fractions were measured by a capacitance technique. Flow regime transition was observed with high speed photography. A 1-hr contact time between Freon-11 and nitrogen at 130 0 F and 60 psig was found to greatly affect the steady-state subcooled boiling initial conditions. Delay in bubble growth was observed in adiabatic blowdown runs. This was caused by the thermodynamic nonequilibrium conditions required for the unstable bubble growth. For the diabatic runs, equilibrium was more closely approached in the test section during the early phase of blowdown. Critical heat flux did not occur immediately during the flow decay in an approximately 60 msec reversal period. The first or early CHF which occurred at about 400 msec was independent of the blowdown volume and did not propagate upward. An annular flow pattern appeared at the onset of this CHF which occurred only at the lower 8 in. of the heated zone

Network modeling for reverse flows of end-of-life vehicles

International Nuclear Information System (INIS)

Ene, Seval; Öztürk, Nursel

2015-01-01

Highlights: • We developed a network model for reverse flows of end-of-life vehicles. • The model considers all recovery operations for end-of-life vehicles. • A scenario-based model is used for uncertainty to improve real case applications. • The model is adequate to real case applications for end-of-life vehicles recovery. • Considerable insights are gained from the model by sensitivity analyses. - Abstract: Product recovery operations are of critical importance for the automotive industry in complying with environmental regulations concerning end-of-life products management. Manufacturers must take responsibility for their products over the entire life cycle. In this context, there is a need for network design methods for effectively managing recovery operations and waste. The purpose of this study is to develop a mathematical programming model for managing reverse flows in end-of-life vehicles’ recovery network. A reverse flow is the collection of used products from consumers and the transportation of these products for the purpose of recycling, reuse or disposal. The proposed model includes all operations in a product recovery and waste management network for used vehicles and reuse for vehicle parts such as collection, disassembly, refurbishing, processing (shredding), recycling, disposal and reuse of vehicle parts. The scope of the network model is to determine the numbers and locations of facilities in the network and the material flows between these facilities. The results show the performance of the model and its applicability for use in the planning of recovery operations in the automotive industry. The main objective of recovery and waste management is to maximize revenue and minimize pollution in end-of-life product operations. This study shows that with an accurate model, these activities may provide economic benefits and incentives in addition to protecting the environment

Network modeling for reverse flows of end-of-life vehicles

Energy Technology Data Exchange (ETDEWEB)

Ene, Seval; Öztürk, Nursel

2015-04-15

Highlights: • We developed a network model for reverse flows of end-of-life vehicles. • The model considers all recovery operations for end-of-life vehicles. • A scenario-based model is used for uncertainty to improve real case applications. • The model is adequate to real case applications for end-of-life vehicles recovery. • Considerable insights are gained from the model by sensitivity analyses. - Abstract: Product recovery operations are of critical importance for the automotive industry in complying with environmental regulations concerning end-of-life products management. Manufacturers must take responsibility for their products over the entire life cycle. In this context, there is a need for network design methods for effectively managing recovery operations and waste. The purpose of this study is to develop a mathematical programming model for managing reverse flows in end-of-life vehicles’ recovery network. A reverse flow is the collection of used products from consumers and the transportation of these products for the purpose of recycling, reuse or disposal. The proposed model includes all operations in a product recovery and waste management network for used vehicles and reuse for vehicle parts such as collection, disassembly, refurbishing, processing (shredding), recycling, disposal and reuse of vehicle parts. The scope of the network model is to determine the numbers and locations of facilities in the network and the material flows between these facilities. The results show the performance of the model and its applicability for use in the planning of recovery operations in the automotive industry. The main objective of recovery and waste management is to maximize revenue and minimize pollution in end-of-life product operations. This study shows that with an accurate model, these activities may provide economic benefits and incentives in addition to protecting the environment.

Predicting Flow Reversals in a Computational Fluid Dynamics Simulated Thermosyphon Using Data Assimilation.

Science.gov (United States)

Reagan, Andrew J; Dubief, Yves; Dodds, Peter Sheridan; Danforth, Christopher M

2016-01-01

A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth's weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA) methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF) to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD) of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction.

Predicting Flow Reversals in a Computational Fluid Dynamics Simulated Thermosyphon Using Data Assimilation.

Directory of Open Access Journals (Sweden)

Andrew J Reagan

Full Text Available A thermal convection loop is a annular chamber filled with water, heated on the bottom half and cooled on the top half. With sufficiently large forcing of heat, the direction of fluid flow in the loop oscillates chaotically, dynamics analogous to the Earth's weather. As is the case for state-of-the-art weather models, we only observe the statistics over a small region of state space, making prediction difficult. To overcome this challenge, data assimilation (DA methods, and specifically ensemble methods, use the computational model itself to estimate the uncertainty of the model to optimally combine these observations into an initial condition for predicting the future state. Here, we build and verify four distinct DA methods, and then, we perform a twin model experiment with the computational fluid dynamics simulation of the loop using the Ensemble Transform Kalman Filter (ETKF to assimilate observations and predict flow reversals. We show that using adaptively shaped localized covariance outperforms static localized covariance with the ETKF, and allows for the use of less observations in predicting flow reversals. We also show that a Dynamic Mode Decomposition (DMD of the temperature and velocity fields recovers the low dimensional system underlying reversals, finding specific modes which together are predictive of reversal direction.

Impact of drag reducing polymers on the onset of instability in a pipe with reverse flow

Science.gov (United States)

Shashank, H. J.; Sreenivas, K. R.

2014-11-01

The objective of this study is to understand the mechanism by which drag reducing polymer (DRP) additives modify turbulent flow, so as to reduce turbulent drag. Reverse flow in a pipe occurs when the fluid close to the wall moves in an opposite direction to that of the core fluid. Reverse flow is established by using a piston-cylinder mechanism, the programmed motion of which imparts a known impulse to the fluid. When the piston is stopped at the end of the stroke, fluid inertia makes the core of the flow to continue in the same direction. In order to conserve mass, reverse flow is established close to the wall. An inflection point is thus formed, leading to flow instability above a critical Reynolds number. Dye and streak flow visualization experiments are performed to highlight the impact of DRP additives (polyethylene oxide, PEO, dissolved in water). The time of onset of the instability and the wavelength of the observed instability are studied in systems with and without DRP additives. This study will provide further insight into the phenomenon of turbulent polymer drag reduction.

Reverse capillary flow of condensed water through aligned multiwalled carbon nanotubes

International Nuclear Information System (INIS)

Yun, Jongju; Jeon, Wonjae; Alam Khan, Fakhre; Lee, Jinkee; Baik, Seunghyun

2015-01-01

Molecular transport through nanopores has recently received considerable attention as a result of advances in nanofabrication and nanomaterial synthesis technologies. Surprisingly, water transport investigations through carbon nanochannels resulted in two contradicting observations: extremely fast transport or rejection of water molecules. In this paper, we elucidate the mechanism of impeded water vapor transport through the interstitial space of aligned multiwalled carbon nanotubes (aligned-MWCNTs)—capillary condensation, agglomeration, reverse capillary flow, and removal by superhydrophobicity at the tip of the nanotubes. The origin of separation comes from the water’s phase change from gas to liquid, followed by reverse capillary flow. First, the saturation water vapor pressure is decreased in a confined space, which is favorable for the phase change of incoming water vapor into liquid drops. Once continuous water meniscus is formed between the nanotubes by the adsoprtion and agglomeration of water molecules, a high reverse Laplace pressure is induced in the mushroom-shaped liquid meniscus at the entry region of the aligned-MWCNTs. The reverse Laplace pressure can be significantly enhanced by decreasing the pore size. Finally, the droplets pushed backward by the reverse Laplace pressure can be removed by superhydrophobicity at the tip of the aligned-MWCNTs. The analytical analysis was also supported by experiments carried out using 4 mm-long aligned-MWCNTs with different intertube distances. The water rejection rate and the separation factor increased as the intertube distance decreased, resulting in 90% and 10, respectively, at an intertube distance of 4 nm. This mechanism and nanotube membrane may be useful for energy-efficient water vapor separation and dehumidification. (paper)

Reversible logic gates based on enzyme-biocatalyzed reactions and realized in flow cells: a modular approach.

Science.gov (United States)

Fratto, Brian E; Katz, Evgeny

2015-05-18

Reversible logic gates, such as the double Feynman gate, Toffoli gate and Peres gate, with 3-input/3-output channels are realized using reactions biocatalyzed with enzymes and performed in flow systems. The flow devices are constructed using a modular approach, where each flow cell is modified with one enzyme that biocatalyzes one chemical reaction. The multi-step processes mimicking the reversible logic gates are organized by combining the biocatalytic cells in different networks. This work emphasizes logical but not physical reversibility of the constructed systems. Their advantages and disadvantages are discussed and potential use in biosensing systems, rather than in computing devices, is suggested. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Early detection of preferential channeling in reverse electrodialysis

NARCIS (Netherlands)

Vermaas, David; Saakes, Michel; Nijmeijer, Dorothea C.

2014-01-01

Membrane applications often experience fouling, which prevent uniform flow distribution through the feed water compartments, i.e. preferential channeling may occur. This research shows the effect of preferential channeling on energy generation from mixing salt water and fresh water using reverse

Toroidal equilibrium states with reversed magnetic shear and parallel flow in connection with the formation of Internal Transport Barriers

Science.gov (United States)

Kuiroukidis, Ap.; Throumoulopoulos, G. N.

2015-08-01

We construct nonlinear toroidal equilibria of fixed diverted boundary shaping with reversed magnetic shear and flows parallel to the magnetic field. The equilibria have hole-like current density and the reversed magnetic shear increases as the equilibrium nonlinearity becomes stronger. Also, application of a sufficient condition for linear stability implies that the stability is improved as the equilibrium nonlinearity correlated to the reversed magnetic shear gets stronger with a weaker stabilizing contribution from the flow. These results indicate synergetic stabilizing effects of reversed magnetic shear, equilibrium nonlinearity and flow in the establishment of Internal Transport Barriers (ITBs).

Asymmetry reversal of ion collection by mach probes in flowing unmagnetized plasmas

International Nuclear Information System (INIS)

Ko, E; Hershkowitz, N

2006-01-01

Measurements of ion current in flowing unmagnetized plasmas were performed with planar and spherical Mach probes in two different devices, one a dc multi-dipole plasma device for subsonic flow within a presheath region and the other a double plasma device for supersonic flow. Asymmetry reversal, which is higher ion current to the downstream side of the probe compared with the upstream side current, was observed for high probe bias compared with the electron temperature, relatively low ion drift velocity and Debye length comparable to probe radius. These data are in qualitative agreement with a recent numerical calculation by Hutchinson. As suggested by Hutchinson, it was found that the current ratio depended on the plasma parameters, especially for finite Debye length and high probe bias. Asymmetry reversal emphasizes the lack of validity of using the current ratio except for narrow parameter ranges. This study is the first experiment to demonstrate the non-intuitive phenomenon predicted by Hutchinson's numerical calculation

Reversing tidal flow and estuarine morphodynamics in the Metronome laboratory flume

NARCIS (Netherlands)

Kleinhans, M.G.; Leuven, J.R.F.W.; Braat, L.; van der Vegt, M.; van Maarseveen, M.C.G.; Markies, H.; Roosendaal, C.; van Eijk, A.M.

2016-01-01

Our objective is to test a novel experimental principle for creating reversing tidal flows of sufficient strength to cause estuarine morphodynamics. The study of estuarine morphodynamics has hitherto been limited to field observation and numerical modelling, whilst fluvial morphodynamics have

Reversing flow catalytic converter for a natural gas/diesel dual fuel engine

Energy Technology Data Exchange (ETDEWEB)

Liu, E.; Checkel, M.D. [Alberta Univ., Edmonton, AB (Canada). Dept. of Mechanical Engineering; Hayes, R.E. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering; Alberta Univ., Edmonton, AB (Canada). Dept. of Mechanical Engineering; Zheng, M.; Mirosh, E. [Alternative Fuel Systems Inc., Calgary, AB (Canada)

2001-07-01

An experimental and modelling study was performed for a reverse flow catalytic converter attached to a natural gas/diesel dual fuel engine. The catalytic converter had a segmented ceramic monolith honeycomb substrate and a catalytic washcoat containing a predominantly palladium catalyst. A one-dimensional single channel model was used to simulate the operation of the converter. The kinetics of the CO and methane oxidation followed first-order behaviour. The activation energy for the oxidation of methane showed a change with temperature, dropping from a value of 129 to 35 kJ/mol at a temperature of 874 K. The reverse flow converter was able to achieve high reactor temperature under conditions of low inlet gas temperature, provided that the initial reactor temperature was sufficiently high. (author)

REVERSE CHARGE AND THE CASH FLOW OF THE PUBLIC BUDGETS IN THE CZECH REPUBLIC

Directory of Open Access Journals (Sweden)

Kohoutková Růžena

2015-12-01

Full Text Available Reverse charge is currently used as a measure against VAT carousel fraud. Its extension to all goods and services is discussed among the tax policy makers at the national and EU level. Opponents of general reverse-charge argue that this method of VAT collection would completely change the nature of the VAT system. One of the practical drawbacks of reverse charge is the negative impact on the cash flow of the public budgets. This article quantifies the average monthly financing available to the State thanks to delayed repayments of input tax to VAT payers under the normal VAT system. This amount equals to almost 53 billion CZK and represents the negative impact of the general reverse charge on the cash flow of the public budgets. A change in the deadline for remitting VAT or introducing VAT advances to be paid prior to the final tax payment would reduce the negative influence on public finances.

Behavioural treatment of tics: Habit reversal and exposure with response prevention

NARCIS (Netherlands)

Griendt, J.M.T.M. van de; Verdellen, C.W.J.; Dijk, M.K. van; Verbraak, M.J.P.M.

2013-01-01

Behaviour therapy has been shown to be an effective strategy in treating tics; both habit reversal (HR) and exposure and response prevention (ER) are recommended as first-line interventions. This review provides an overview of the history, theoretical concepts and evidence at present for HR and ER.

Local wettability reversal during steady-state two-phase flow in porous media.

Science.gov (United States)

Sinha, Santanu; Grøva, Morten; Ødegården, Torgeir Bryge; Skjetne, Erik; Hansen, Alex

2011-09-01

We study the effect of local wettability reversal on remobilizing immobile fluid clusters in steady-state two-phase flow in porous media. We consider a two-dimensional network model for a porous medium and introduce a wettability alteration mechanism. A qualitative change in the steady-state flow patterns, destabilizing the percolating and trapped clusters, is observed as the system wettability is varied. When capillary forces are strong, a finite wettability alteration is necessary to move the system from a single-phase to a two-phase flow regime. When both phases are mobile, we find a linear relationship between fractional flow and wettability alteration.

Liquid flow along a solid surface reversibly alters interfacial chemistry.

Science.gov (United States)

Lis, Dan; Backus, Ellen H G; Hunger, Johannes; Parekh, Sapun H; Bonn, Mischa

2014-06-06

In nature, aqueous solutions often move collectively along solid surfaces (for example, raindrops falling on the ground and rivers flowing through riverbeds). However, the influence of such motion on water-surface interfacial chemistry is unclear. In this work, we combine surface-specific sum frequency generation spectroscopy and microfluidics to show that at immersed calcium fluoride and fused silica surfaces, flow leads to a reversible modification of the surface charge and subsequent realignment of the interfacial water molecules. Obtaining equivalent effects under static conditions requires a substantial change in bulk solution pH (up to 2 pH units), demonstrating the coupling between flow and chemistry. These marked flow-induced variations in interfacial chemistry should substantially affect our understanding and modeling of chemical processes at immersed surfaces. Copyright © 2014, American Association for the Advancement of Science.

Experimental and modelling study of reverse flow catalytic converters for natural gas/diesel dual fuel engine pollution control

Energy Technology Data Exchange (ETDEWEB)

Liu, B.

2000-07-01

There is renewed interest in the development of natural gas vehicles in response to the challenge to reduce urban air pollution and consumption of petroleum. The natural gas/diesel dual fuel engine is one way to apply natural gas to the conventional diesel engine. Dual fuel engines operating on natural gas and diesel emit less nitrogen oxides, and less carbon soot to the air compared to conventional diesel engines. The problem is that at light loads, fuel efficiency is reduced and emissions of hydrocarbons and carbon monoxide are increased. This thesis focused on control methods for emissions of hydrocarbons and carbon monoxide in the dual fuel engine at light loads. This was done by developing a reverse flow catalytic converter to complement dual fuel engine exhaust characteristics. Experimental measurements and numerical simulations of reverse flow catalytic converters were conducted. Reverse flow creates a high reactor temperature even when the engine is run at low exhaust temperature levels at light loads. The increase in reactor temperature from reverse flow could be 2 or 3 times higher than the adiabatic temperature increase, which is based on the reactor inlet temperature and concentration. This temperature makes it possible for greater than 90 per cent of the hydrocarbon and carbon monoxide to be converted with a palladium based catalyst. Reverse flow appears to be better than conventional unidirectional flow to deal with natural gas/diesel dual fuel engine pollution at light loads. Reverse flow could also maintain reactor temperature at over 800 K and hydrocarbon conversion at about 80 per cent during testing. The newly presented model simulates reactor performance with reasonable accuracy. Both carbon monoxide and methane oxidation over the palladium catalyst in excess oxygen and water were described using first order kinetics.

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.

Directory of Open Access Journals (Sweden)

Sun Woo Sophie Kang

Full Text Available Mitochondrial damage is the major factor underlying drug-induced liver disease but whether conditions that thwart mitochondrial injury can prevent or reverse drug-induced liver damage is unclear. A key molecule regulating mitochondria quality control is AMP activated kinase (AMPK. When activated, AMPK causes mitochondria to elongate/fuse and proliferate, with mitochondria now producing more ATP and less reactive oxygen species. Autophagy is also triggered, a process capable of removing damaged/defective mitochondria. To explore whether AMPK activation could potentially prevent or reverse the effects of drug-induced mitochondrial and hepatocellular damage, we added an AMPK activator to collagen sandwich cultures of rat and human hepatocytes exposed to the hepatotoxic drugs, acetaminophen or diclofenac. In the absence of AMPK activation, the drugs caused hepatocytes to lose polarized morphology and have significantly decreased ATP levels and viability. At the subcellular level, mitochondria underwent fragmentation and had decreased membrane potential due to decreased expression of the mitochondrial fusion proteins Mfn1, 2 and/or Opa1. Adding AICAR, a specific AMPK activator, at the time of drug exposure prevented and reversed these effects. The mitochondria became highly fused and ATP production increased, and hepatocytes maintained polarized morphology. In exploring the mechanism responsible for this preventive and reversal effect, we found that AMPK activation prevented drug-mediated decreases in Mfn1, 2 and Opa1. AMPK activation also stimulated autophagy/mitophagy, most significantly in acetaminophen-treated cells. These results suggest that activation of AMPK prevents/reverses drug-induced mitochondrial and hepatocellular damage through regulation of mitochondrial fusion and autophagy, making it a potentially valuable approach for treatment of drug-induced liver injury.

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

Science.gov (United States)

Taniane, Caitlin; Farrell, Geoffrey; Arias, Irwin M.; Lippincott-Schwartz, Jennifer; Fu, Dong

2016-01-01

Mitochondrial damage is the major factor underlying drug-induced liver disease but whether conditions that thwart mitochondrial injury can prevent or reverse drug-induced liver damage is unclear. A key molecule regulating mitochondria quality control is AMP activated kinase (AMPK). When activated, AMPK causes mitochondria to elongate/fuse and proliferate, with mitochondria now producing more ATP and less reactive oxygen species. Autophagy is also triggered, a process capable of removing damaged/defective mitochondria. To explore whether AMPK activation could potentially prevent or reverse the effects of drug-induced mitochondrial and hepatocellular damage, we added an AMPK activator to collagen sandwich cultures of rat and human hepatocytes exposed to the hepatotoxic drugs, acetaminophen or diclofenac. In the absence of AMPK activation, the drugs caused hepatocytes to lose polarized morphology and have significantly decreased ATP levels and viability. At the subcellular level, mitochondria underwent fragmentation and had decreased membrane potential due to decreased expression of the mitochondrial fusion proteins Mfn1, 2 and/or Opa1. Adding AICAR, a specific AMPK activator, at the time of drug exposure prevented and reversed these effects. The mitochondria became highly fused and ATP production increased, and hepatocytes maintained polarized morphology. In exploring the mechanism responsible for this preventive and reversal effect, we found that AMPK activation prevented drug-mediated decreases in Mfn1, 2 and Opa1. AMPK activation also stimulated autophagy/mitophagy, most significantly in acetaminophen-treated cells. These results suggest that activation of AMPK prevents/reverses drug-induced mitochondrial and hepatocellular damage through regulation of mitochondrial fusion and autophagy, making it a potentially valuable approach for treatment of drug-induced liver injury. PMID:27792760

Network modeling for reverse flows of end-of-life vehicles.

Science.gov (United States)

Ene, Seval; Öztürk, Nursel

2015-04-01

Product recovery operations are of critical importance for the automotive industry in complying with environmental regulations concerning end-of-life products management. Manufacturers must take responsibility for their products over the entire life cycle. In this context, there is a need for network design methods for effectively managing recovery operations and waste. The purpose of this study is to develop a mathematical programming model for managing reverse flows in end-of-life vehicles' recovery network. A reverse flow is the collection of used products from consumers and the transportation of these products for the purpose of recycling, reuse or disposal. The proposed model includes all operations in a product recovery and waste management network for used vehicles and reuse for vehicle parts such as collection, disassembly, refurbishing, processing (shredding), recycling, disposal and reuse of vehicle parts. The scope of the network model is to determine the numbers and locations of facilities in the network and the material flows between these facilities. The results show the performance of the model and its applicability for use in the planning of recovery operations in the automotive industry. The main objective of recovery and waste management is to maximize revenue and minimize pollution in end-of-life product operations. This study shows that with an accurate model, these activities may provide economic benefits and incentives in addition to protecting the environment. Copyright © 2015 Elsevier Ltd. All rights reserved.

Structural and temporal requirements for geomagnetic field reversal deduced from lava flows.

Science.gov (United States)

Singer, Brad S; Hoffman, Kenneth A; Coe, Robert S; Brown, Laurie L; Jicha, Brian R; Pringle, Malcolm S; Chauvin, Annick

2005-03-31

Reversals of the Earth's magnetic field reflect changes in the geodynamo--flow within the outer core--that generates the field. Constraining core processes or mantle properties that induce or modulate reversals requires knowing the timing and morphology of field changes that precede and accompany these reversals. But the short duration of transitional field states and fragmentary nature of even the best palaeomagnetic records make it difficult to provide a timeline for the reversal process. 40Ar/39Ar dating of lavas on Tahiti, long thought to record the primary part of the most recent 'Matuyama-Brunhes' reversal, gives an age of 795 +/- 7 kyr, indistinguishable from that of lavas in Chile and La Palma that record a transition in the Earth's magnetic field, but older than the accepted age for the reversal. Only the 'transitional' lavas on Maui and one from La Palma (dated at 776 +/- 2 kyr), agree with the astronomical age for the reversal. Here we propose that the older lavas record the onset of a geodynamo process, which only on occasion would result in polarity change. This initial instability, associated with the first of two decreases in field intensity, began approximately 18 kyr before the actual polarity switch. These data support the claim that complete reversals require a significant period for magnetic flux to escape from the solid inner core and sufficiently weaken its stabilizing effect.

A Novel Method of Protection to Prevent Reverse Power Flow Based on Neuro-Fuzzy Networks for Smart Grid

Directory of Open Access Journals (Sweden)

Ali Hadi Abdulwahid

2018-04-01

Full Text Available This paper addresses the energy challenges related to the weak protection of renewable energy from reverse energy flow and expanding access to high-quality energy at the same time. Furthermore, this paper focuses on participation in the global transition to clean and low-carbon energy systems. Moreover, the increased demand for renewable energy seems to likely depend on whether it will be possible to greatly accelerate rates of progress toward increased efficiency, de-carbonization, greater generating diversity and lower pollutant emissions. This paper focuses on the protection of renewable energy technologies because they can be particularly attractive in dispersed areas and therefore, represent an important option for rural areas that lack electrical energy and distribution infrastructure. This paper proposes an improved protection device for a reverse power protection system using a new intelligent decision support system (IDSS. The IDSS is a support system for decision making, which makes extensive use of artificial intelligence (AI techniques. The new method integrates the powerful specification for neural networks and fuzzy inference systems. The main advantage of this method is that it causes a decrease in the steady state oscillation for the reverse power relay. In addition, the proposed method has the ability to monitor extreme environmental conditions. The generator can be converted into a motor when the steam supply to a turbine is interrupted while the generator is still connected to a grid (or operates in parallel with another generator. As a result, the generator will become a synchronous motor and will actually cause significant mechanical damage. The reverse energy protection device should be included in the generator protection scheme. Smart grids use communication networks with sophisticated algorithms to ensure coordination between protection systems. ZigBee is a newly developed technology that can be used in wireless sensor

Yield of reversible colloidal gels during flow start-up: release from kinetic arrest.

Science.gov (United States)

Johnson, Lilian C; Landrum, Benjamin J; Zia, Roseanna N

2018-06-05

Yield of colloidal gels during start-up of shear flow is characterized by an overshoot in shear stress that accompanies changes in network structure. Prior studies of yield of reversible colloidal gels undergoing strong flow model the overshoot as the point at which network rupture permits fluidization. However, yield under weak flow, which is of interest in many biological and industrial fluids shows no such disintegration. The mechanics of reversible gels are influenced by bond strength and durability, where ongoing rupture and re-formation impart aging that deepens kinetic arrest [Zia et al., J. Rheol., 2014, 58, 1121], suggesting that yield be viewed as release from kinetic arrest. To explore this idea, we study reversible colloidal gels during start-up of shear flow via dynamic simulation, connecting rheological yield to detailed measurements of structure, bond dynamics, and potential energy. We find that pre-yield stress grows temporally with the changing roles of microscopic transport processes: early time behavior is set by Brownian diffusion; later, advective displacements permit relative particle motion that stretches bonds and stores energy. Stress accumulates in stretched, oriented bonds until yield, which is a tipping point to energy release, and is passed with a fully intact network, where the loss of very few bonds enables relaxation of many, easing glassy arrest. This is immediately followed by a reversal to growth in potential energy during bulk plastic deformation and condensation into larger particle domains, supporting the view that yield is an activated release from kinetic arrest. The continued condensation of dense domains and shrinkage of network surfaces, along with a decrease in the potential energy, permit the gel to evolve toward more complete phase separation, supporting our view that yield of weakly sheared gels is a 'non-equilibrium phase transition'. Our findings may be particularly useful for industrial or other coatings, where weak

Experimental study on fundamental performance of reverse flow diverters

International Nuclear Information System (INIS)

Fan Yanfang; Xu Cong; Jing Shan

2008-01-01

The Reverse Flow Diverter (RFD) is one of the key components affecting the liquid-delivered efficiency. The effects of inflow structure, outflow structure, area ratio and suction gap on the performance of RFDs were studied in this paper. It can be found experimentally that expected entrainment phenomenon can be achieved when the outlet velocity of fluid for RFDs' inflow structure is sufficient. There is less liquid delivered by an RFD with a long receiver than that without a receiver. Because of back-flow caused by vortex separation, oversize area ratio cannot have better entrainment phenomenon and the optimum area ratio is 1.5. When the ratio of suction gap length to inlet diameter of outflow structure is 0.9-1.0, the excellent liquid-delivered efficiency can be obtained. (authors)

On Variable Reverse Power Flow-Part I: Active-Reactive Optimal Power Flow with Reactive Power of Wind Stations

Directory of Open Access Journals (Sweden)

Aouss Gabash

2016-02-01

Full Text Available It has recently been shown that using battery storage systems (BSSs to provide reactive power provision in a medium-voltage (MV active distribution network (ADN with embedded wind stations (WSs can lead to a huge amount of reverse power to an upstream transmission network (TN. However, unity power factors (PFs of WSs were assumed in those studies to analyze the potential of BSSs. Therefore, in this paper (Part-I, we aim to further explore the pure reactive power potential of WSs (i.e., without BSSs by investigating the issue of variable reverse power flow under different limits on PFs in an electricity market model. The main contributions of this work are summarized as follows: (1 Introducing the reactive power capability of WSs in the optimization model of the active-reactive optimal power flow (A-R-OPF and highlighting the benefits/impacts under different limits on PFs. (2 Investigating the impacts of different agreements for variable reverse power flow on the operation of an ADN under different demand scenarios. (3 Derivation of the function of reactive energy losses in the grid with an equivalent-π circuit and comparing its value with active energy losses. (4 Balancing the energy curtailment of wind generation, active-reactive energy losses in the grid and active-reactive energy import-export by a meter-based method. In Part-II, the potential of the developed model is studied through analyzing an electricity market model and a 41-bus network with different locations of WSs.

RELAP5 analyses of two hypothetical flow reversal events for the Advanced Neutron Source Reactor

International Nuclear Information System (INIS)

Chen, N.C.J.; Wendel, M.W.; Yoder, G.L. Jr.

1995-01-01

The reactor design features 4 independent cooling loops (3 active, 1 standby), each containing a main circulation pump (with battery powered pony motor), heat exchanger, an accumulator, and a check valve. The first transient assumes one of these pumps fails, and also that the check valve in that loop remains stuck open. This accident is considered extremely unlikely. Flow reverses in this loop, reducing core flow because much of the coolant is diverted from the intact loops back through the failed loop. The second transient examines a 102-mm-dia instantaneous pipe break near the core inlet (worst break location). A break is assumed to occur 90 s after a total loss-of-offsite power. Core flow reversal occurs because accumulator injection overpowers the diminishing pump flow. Safety margins are evaluated against 4 thermal limits: T wall = T sat , incipient boiling, onset of significant void, and critical heat flux. For the first transient, results show that these limits are not exceeded (at 95% non-exceedance probability level) if the pony motor battery lasts 30 minutes (present design value). For the second transient, the closest approach of the fuel surface temperature to local saturation temperature during core flow reversal is about 39 C, so the fuel remains cool during this transient. Although this work is for the ANSR geometry and operating conditions, the general conclusion may be applicable to other highly subcooled reactor systems

A Systematic Review of Outcomes and Complications of Primary Fingertip Reconstruction Using Reverse-Flow Homodigital Island Flaps.

Science.gov (United States)

Regmi, Subhash; Gu, Jia-xiang; Zhang, Nai-chen; Liu, Hong-jun

2016-04-01

Fingertip reconstruction using reverse-flow homodigital island flaps has been very popular over the years. However, the outcomes of reconstruction have not been clearly understood. In these circumstances, a systematic review of available literature is warranted. To assess the outcomes and complications of fingertip reconstruction using reverse-flow homodigital island flaps. To justify the usage of reverse-flow homodigital island flaps for fingertip reconstruction. A PubMed [MEDLINE] electronic database was searched (1985 to 15 April 2015). Retrospective case series that met the following criteria were included: (1) Study reported primary data; (2) Study included at least five cases of fingertip defects treated using reverse-flow homodigital island flaps; (3) Study reported outcomes and complications of fingertip reconstruction, either primary or delayed, using reverse-flow homodigital island flaps; (4) The study presented at least one of the following functional outcomes: Static two-point discrimination, return-to-work time, range of motion of distal interphalangeal joints; (5) The study presented at least one complication. Two review authors independently assessed search results, and two other review authors analyzed the data and resolved disagreements. The following endpoints were analyzed: survival rate of the flap, sensibility, and functional outcomes and complications. Eight studies were included in this review. The included studies were published between 1995 and 2014, and a total of 207 patients with 230 fingertip defects were reported. The overall survival rate of the flap was 98 % (including partial survival). The mean static two-point discrimination (2PD) was 7.2 mm. The average range of motion of the DIP joint was 63°. The average return-to-work time was 7 weeks after injury. On average, 2 % of the patient had complete flap necrosis, 5 % had partial flap necrosis, 4 % developed venous congestion, 4 % developed flexion contracture, and 12 % experienced

Numerical simulation of wind-sand movement in the reversed flow region of a sand dune with a bridge built downstream.

Science.gov (United States)

He, Wei; Huang, Ning; Xu, Bin; Wang, Wenbo

2018-04-23

A bridge built inside the reversed flow region of a sand dune will change the characteristics of wind-sand movement in this region. The Reynolds-averaged Navier-Stokes simulation and discrete particle tracing are used to simulate the wind-sand movement around a sand dune with a bridge built inside the reversed region. Three cases with different bridge positions are studied. The results show that 1) compared with the isolated dune case, a tall bridge built at the leeward toe leads to an increase in the deposition rate on the leeward slope and a longer reversed flow region downstream of the sand dune; meanwhile, the high speed of crosswind on the bridge indicates that some measures should be taken to protect trains from strong crosswind; 2) a low bridge at the leeward toe has little effect on the sand deposition and reversed flow region of the dune; however, low sand transport rate and crosswind speed on the bridge show that anti-crosswind/sand measures should be taken according to the actual situation and 3) a low bridge on the leeward slope has little effect on the length of reversed flow region, however, high crosswind speed and sand flux on the bridge reveal the need of anti-crosswind/sand measures on the bridge. Moreover, the bridges in the reversed flow region increase the sand flux near the leeward crest; as a result, the moving patterns of the sand dune are changed.

RELAP5 analyses of two hypothetical flow reversal events for the advanced neutron source reactor

Energy Technology Data Exchange (ETDEWEB)

Chen, N.C.J.; Wendel, M.W.; Yoder, G.L. Jr. [Oak Ridge National Lab., TN (United States)

1995-09-01

This paper presents RELAP5 results of two hypothetical, low flow transients analyzed as part of the Advanced Neutron Source Reactor safety program. The reactor design features four independent coolant loops (three active and one in standby), each containing a main curculation pump (with battery powered pony motor), heat exchanger, an accumulator, and a check valve. The first transient assumes one of these pumps fails, and additionally, that the check valve in that loop remains stuck in the open position. This accident is considered extremely unlikely. Flow reverses in this loop, reducing the core flow because much of the coolant is diverted from the intact loops back through the failed loop. The second transient examines a 102-mm-diam instantaneous pipe break near the core inlet (the worst break location). A break is assumed to occur 90 s after a total loss-of-offsite power. Core flow reversal occurs because accumulator injection overpowers the diminishing pump flow. Safety margins are evaluated against four thermal limits: T{sub wall}=T{sub sat}, incipient boiling, onset of significant void, and critical heat flux. For the first transient, the results show that these limits are not exceeded (at a 95% non-exceedance probability level) if the pony motor battery lasts 30 minutes (the present design value). For the second transient, the results show that the closest approach of the fuel surface temperature to the local saturation temperature during core flow reversal is about 39{degrees}C. Therefore the fuel remains cool during this transient. Although this work is done specifically for the ANSR geometry and operating conditions, the general conclusions may be applicable to other highly subcooled reactor systems.

Passive Flap Actuation by Reversing Flow in Laminar Boundary Layer Separation

Science.gov (United States)

Parsons, Chase; Lang, Amy; Santos, Leo; Bonacci, Andrew

2017-11-01

Reducing the flow separation is of great interest in the field of fluid mechanics in order to reduce drag and improve the overall efficiency of aircraft. This project seeks to investigate passive flow control using shark inspired microflaps in laminar boundary layer separation. This study aims to show that whether a flow is laminar or turbulent, laminar and 2D or turbulent and 3D, microflaps actuated by reversing flow is a robust means of controlling flow separation. In order to generate a controlled adverse pressure gradient, a rotating cylinder induces separation at a chosen location on a flat plate boundary layer with Re above 10000. Within this thick boundary layer, digital particle image velocimetry is used to map the flow. This research can be used in the future to better understand the nature of the bristling shark scales and its ability to passively control separation. Results show that microflaps successfully actuated due to backflow and that this altered the formation of flow separation. I would like to thank the NSF for REU Grant EEC 1659710 and the Army Research Office for funding this project.

Air purification by catalytic oxidation in a reactor with periodic flow reversal

NARCIS (Netherlands)

van de Beld, L.; van de Beld, Bert; Westerterp, K.R.

1994-01-01

The behaviour of an adiabatic packed bed reactor with periodic flow reversal has been studied by means of model calculations. A heterogeneous model as well as a pseudo-homogeneous model have been developed. It is shown that a high degree of conversion can be obtained in an autothermal process even

Reversible flowchart languages and the structured reversible program theorem

DEFF Research Database (Denmark)

Yokoyama, Tetsuo; Axelsen, Holger Bock; Glück, Robert

2008-01-01

Many irreversible computation models have reversible counterparts, but these are poorly understood at present. We introduce reversible flowcharts with an assertion operator and show that any reversible flowchart can be simulated by a structured reversible flowchart using only three control flow...... operators. Reversible flowcharts are r- Turing-complete, meaning that they can simuluate reversible Turing machines without garbage data. We also demonstrate the injectivization of classical flowcharts into reversible flowcharts. The reversible flowchart computation model provides a theoretical...

Dynamic Behavior of Reverse Flow Reactor for Lean Methane Combustion

OpenAIRE

Yogi W. Budhi; M. Effendy; Yazid Bindar; Subagjo

2014-01-01

The stability of reactor operation for catalytic oxidation of lean CH4 has been investigated through modeling and simulation, particularly the influence of switching time and heat extraction on reverse flow reactor (RFR) performance. A mathematical model of the RFR was developed, based on one-dimensional pseudo-homogeneous model for mass and heat balances, incorporating heat loss through the reactor wall. The configuration of the RFR consisted of inert-catalyst-inert, with or without heat ext...

Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN.

Science.gov (United States)

Kyte, S Lauren; Toma, Wisam; Bagdas, Deniz; Meade, Julie A; Schurman, Lesley D; Lichtman, Aron H; Chen, Zhi-Jian; Del Fabbro, Egidio; Fang, Xianjun; Bigbee, John W; Damaj, M Imad; Gewirtz, David A

2018-01-01

Chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect during and/or after cancer chemotherapy. Paclitaxel, a taxane commonly used to treat breast, lung, and ovarian cancers, causes CIPN in 59-78% of cancer patients. Novel interventions are needed due to the current lack of effective CIPN treatments. Our studies were designed to investigate whether nicotine can prevent and/or reverse paclitaxel-induced peripheral neuropathy in a mouse model of CIPN, while ensuring that nicotine will not stimulate lung tumor cell proliferation or interfere with the antitumor properties of paclitaxel. Male C57BL/6J mice received paclitaxel every other day for a total of four injections (8 mg/kg, i.p.). Acute (0.3-0.9 mg/kg, i.p.) and chronic (24 mg/kg per day, s.c.) administration of nicotine respectively reversed and prevented paclitaxel-induced mechanical allodynia. Blockade of the antinociceptive effect of nicotine with mecamylamine and methyllycaconitine suggests that the reversal of paclitaxel-induced mechanical allodynia is primarily mediated by the α 7 nicotinic acetylcholine receptor subtype. Chronic nicotine treatment also prevented paclitaxel-induced intraepidermal nerve fiber loss. Notably, nicotine neither promoted proliferation of A549 and H460 non-small cell lung cancer cells nor interfered with paclitaxel-induced antitumor effects, including apoptosis. Most importantly, chronic nicotine administration did not enhance Lewis lung carcinoma tumor growth in C57BL/6J mice. These data suggest that the nicotinic acetylcholine receptor-mediated pathways may be promising drug targets for the prevention and treatment of CIPN. Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

Analysis of the interaction between a submerged jet and a receiver-diffuser in a reverse-flow diverter. Consolidated Fuel Reprocessing Program

International Nuclear Information System (INIS)

Smith, G.V.; Counce, R.M.

1983-01-01

Two mathematical models of the interaction between a submerged jet emanating from the nozzle of a reverse flow diverter (RFD) and a receiver-diffuser of a venturi-like reverse flow diverter are presented and compared with experimental data. Both models predict the output characteristics fairly accurately, although the experimentally measured flow is observed to saturate at higher values of jet dynamic pressure and at lower values of output load impedances. An analysis based on the inviscid flow model indicates cavitation as the likely cause of the flow saturation

Core Flow Distribution from Coupled Supercritical Water Reactor Analysis

Directory of Open Access Journals (Sweden)

Po Hu

2014-01-01

Full Text Available This paper introduces an extended code package PARCS/RELAP5 to analyze steady state of SCWR US reference design. An 8 × 8 quarter core model in PARCS and a reactor core model in RELAP5 are used to study the core flow distribution under various steady state conditions. The possibility of moderator flow reversal is found in some hot moderator channels. Different moderator flow orifice strategies, both uniform across the core and nonuniform based on the power distribution, are explored with the goal of preventing the reversal.

Validity of peak expiratory flow measurement in assessing reversibility of airflow obstruction.

Science.gov (United States)

Dekker, F W; Schrier, A C; Sterk, P J; Dijkman, J H

1992-01-01

BACKGROUND: Assessing the reversibility of airflow obstruction by peak expiratory (PEF) measurements would be practicable in general practice, but its usefulness has not been investigated. METHODS: PEF measurements were performed (miniWright peak flow meter) in 73 general practice patients (aged 40 to 84) with a history of asthma or chronic obstructive lung disease before and after 400 micrograms inhaled sulbutamol. The change in PEF was compared with the change in forced expiratory volume in one second (FEV1). Reversible airflow obstruction was analysed in two ways according to previous criteria. When defined as a 9% or greater increase in FEV1 expressed as a percentage of predicted values reversibility was observed in 42% of patients. Relative operating characteristic analysis showed that an absolute improvement in PEF of 60 l/min or more gave optimal discrimination between patients with reversible and irreversible airflow obstruction (the sensitivity and specificity of an increase of 60 l/min in detecting a 9% or more increase in FEV1 as a percentage of predicted values were 68% and 93% respectively, with a positive predictive value of 87%). When defined as an increase of 190 ml or more in FEV1, reversible airflow obstruction was observed in 53% of patients. Again an absolute improvement in PEF of 60 l/min or more gave optimal discrimination between patients with reversible and irreversible airflow obstruction (sensitivity 56%, specificity 94%, and positive predictive value 92%). CONCLUSION: Absolute changes in PEF can be used as a simple technique to diagnose reversible airflow obstruction in patients from general practice. PMID:1519192

Modelling of SOL flows and target asymmetries in JET field reversal experiments with EDGE2D code

International Nuclear Information System (INIS)

Chankin, A.; Coad, J.; Corrigan, G.

1999-11-01

The EDGE2D code with drifts can reproduce the main trends of target asymmetries observed in field reversal experiments. It also re-produces qualitatively the main feature of recent JET results obtained with double-sided reciprocating Langmuir probes introduced near the top of the torus: the reversal of parallel plasma flow with toroidal field reversal. The code results suggest that the major contributor to the observed target asymmetries is the co-current toroidal momentum generated inside the scrape-off layer (SOL) by j r xB forces due to the presence of large up-down pressure asymmetries. Contrary to previous expectations of the predominant role of ExB drifts in creating target asymmetries, ∇B and centrifugal drifts were found to be mainly responsible for both parallel flows and target asymmetries. (author)

Managing Reverse Logistics or Reversing Logistics Management?

OpenAIRE

Brito, Marisa

2004-01-01

textabstractIn the past, supply chains were busy fine-tuning the logistics from raw material to the end customer. Today an increasing flow of products is going back in the chain. Thus, companies have to manage reverse logistics as well.This thesis contributes to a better understanding of reverse logistics. The thesis brings insights on reverse logistics decision-making and it lays down theoretical principles for reverse logistics as a research field.In particular it puts together a framework ...

Evidence from lava flows for complex polarity transitions: The new composite Steens Mountain reversal record

Science.gov (United States)

Jarboe, Nicholas A.; Coe, Robert S.; Glen, Jonathan M. G.

2011-01-01

Geomagnetic polarity transitions may be significantly more complex than are currently depicted in many sedimentary and lava-flow records. By splicing together paleomagnetic results from earlier studies at Steens Mountain with those from three newly studied sections of Oregon Plateau flood basalts at Catlow Peak and Poker Jim Ridge 70–90 km to the southeast and west, respectively, we provide support for this interpretation with the most detailed account of a magnetic field reversal yet observed in volcanic rocks. Forty-five new distinguishable transitional (T) directions together with 30 earlier ones reveal a much more complex and detailed record of the 16.7 Ma reversed (R)-to-normal (N) polarity transition that marks the end of Chron C5Cr. Compared to the earlier R-T-N-T-N reversal record, the new record can be described as R-T-N-T-N-T-R-T-N. The composite record confirms earlier features, adds new west and up directions and an entire large N-T-R-T segment to the path, and fills in directions on the path between earlier directional jumps. Persistent virtual geomagnetic pole (VGP) clusters and separate VGPs have a preference for previously described longitudinal bands from transition study compilations, which suggests the presence of features at the core–mantle boundary that influence the flow of core fluid and distribution of magnetic flux. Overall the record is consistent with the generalization that VGP paths vary greatly from reversal to reversal and depend on the location of the observer. Rates of secular variation confirm that the flows comprising these sections were erupted rapidly, with maximum rates estimated to be 85–120 m ka−1 at Catlow and 130–195 m ka−1 at Poker Jim South. Paleomagnetic poles from other studies are combined with 32 non-transitional poles found here to give a clockwise rotation of the Oregon Plateau of 11.4°± 5.6° with respect to the younger Columbia River Basalt Group flows to the north and 14.5°± 4.6° with respect

Numerical investigation on the energetic performances of conventional and pellet aftertreatment systems in flow-through and reverse-flow designs

Directory of Open Access Journals (Sweden)

Morrone Pietropaolo

2011-01-01

Full Text Available The aim of the paper is the analysis of the energetic performances of structured and pelletized aftertreatment systems in flow-through and reverse-flow designs (passive and active flow control respectively for diesel internal combustion engines. To this purpose, the influence of the engine operating conditions on the system performances has been investigated adopting a one-dimensional time-dependent model. Specifically, the thermal behaviour and the fuel saving capability of several arrangements have been characterized. The analysis has shown that the active emission control system with pelletized design guarantees higher heat retention capability. Furthermore, the numerical model has revealed the significant influence of the solid and exhaust gas temperature on the energy efficiency of the aftertreatment systems and the large effect of exhaust mass flow rate and unburned hydrocarbons concentration.

Reverse primary-side flow in steam generators during natural circulation cooling

International Nuclear Information System (INIS)

Stumpf, H.; Motley, F.; Schultz, R.; Chapman, J.; Kukita, Y.

1987-01-01

A TRAC model of the Large Scale Test Facility with a 3-tube steam-generator model was used to analyze natural-circulation test ST-NC-02. For the steady state at 100% primary mass inventory, TRAC was in excellent agreement with the natural-circulation flow rate, the temperature distribution in the steam-generator tubes, and the temperature drop from the hot leg to the steam-generator inlet plenum. TRAC also predicted reverse flow in the long tubes. At reduced primary mass inventories, TRAC predicted the three natural-circulation flow regimes: single phase, two phase, and reflux condensation. TRAC did not predict the cyclic fill-and-dump phenomenon seen briefly in the test. TRAC overpredicted the two-phase natural-circulation flow rate. Since the core is well cooled at this time, the result is conservative. An important result of the analysis is that TRAC was able to predict the core dryout and heatup at approximately the same primary mass inventory as in the test. 4 refs., 8 figs., 2 tabs

The Effect of Local Irradiation in Prevention and Reversal of Acute Rejection of Transplanted Kidney with High-dose Steroid Pulse

International Nuclear Information System (INIS)

Kim, I. H.; Ha, S. W.; Park, C. I.; Kim, S. T.

1986-01-01

From 1979 to 1984, 39 local allograft irradiations were given to 29 patients: 10 irradiations were administered for prevention and 29 for reversal of acute rejection of transplanted kidney. Three doses of 150 cGy every other day were combined with high-dose of methylprednisolone pulse (1 gm/day) for 3 days. For prevention of acute rejection, local irradiation was delivered on the days 1, 3, and 5 after the transplantation, and for reversal, irradiation started after the diagnosis of acute rejection. Eight out of 10 patients irradiated for prevention had acute allograft rejection, and, what is more, there was no surviving graft at 15 months after transplantation. Reversal of acute rejection was achieved in 71%. When the pre-irradiation level of serum creatinine was below 5.5 mg%, the reversal rate was 93%, but above 5.5 mg% the reversal rate was only 17% (p<0.01). Reirradiation after failure was not successful. Among 15 reversed patients, 7 (47%) had subsequent rejection (s). The functional graft survivals at 6 month, 1, 2, and 3 year were 70%, 65%, 54%, and 65%, respectively. Therapeutic irradiation resulted in better graft survival when serum creatinine was below 5.5 mg% (p<0.001) or when irradiation started within 15 days after the diagnosis of acute rejection (p<0.001)

Experimental investigation of the reverse heat transfer of R134a flow through non-adiabatic coiled capillary tubes

Energy Technology Data Exchange (ETDEWEB)

Zareh, Masoud; Heidari, Mohammad Ghorbani [Islamic Azad University, Tehran (Iran, Islamic Republic of)

2016-07-15

This research represents an experimental investigation of the metastable flow and re-condensation phenomenon through non-adiabatic lateral helical capillary tubes and suction tube heat exchanger. The results show that mass flux ratio has a vital role: It affects metastable flow and also reverse heat transfer phenomenon through non-adiabatic helical capillary tube. Therefore, by increasing of the mass flux ratio, the rate of heat transfer between them decreases. In contrast to the strong rate condition of heat transfer between them, reverse heat transfer or re-condensation maybe happen. Moreover, experimental results show that for R134 flow with mass flux ratio more than 57.84, metastable flow exists in non-adiabatic capillary tube with 0.9144 mm inner diameter, 30 mm coil diameter, 6.18 m length, 4 mm inner diameter of compressor suction tube.

Effect of Temperature Reversion on Hot Ductility and Flow Stress-Strain Curves of C-Mn Continuously Cast Steels

Science.gov (United States)

Dong, Zhihua; Li, Wei; Long, Mujun; Gui, Lintao; Chen, Dengfu; Huang, Yunwei; Vitos, Levente

2015-08-01

The influence of temperature reversion in secondary cooling and its reversion rate on hot ductility and flow stress-strain curve of C-Mn steel has been investigated. Tensile specimens were cooled at various regimes. One cooling regime involved cooling at a constant rate of 100 °C min-1 to the test temperature, while the others involved temperature reversion processes at three different reversion rates before deformation. After hot tensile test, the evolution of mechanical properties of steel was analyzed at various scales by means of microstructure observation, ab initio prediction, and thermodynamic calculation. Results indicated that the temperature reversion in secondary cooling led to hot ductility trough occurring at higher temperature with greater depth. With increasing temperature reversion rate, the low temperature end of ductility trough extended toward lower temperature, leading to wider hot ductility trough with slightly reducing depth. Microstructure examinations indicated that the intergranular fracture related to the thin film-like ferrite and (Fe,Mn)S particles did not changed with varying cooling regimes; however, the Widmanstatten ferrite surrounding austenite grains resulted from the temperature reversion process seriously deteriorated the ductility. In addition, after the temperature reversion in secondary cooling, the peak stress on the flow curve slightly declined and the peak of strain to peak stress occurred at higher temperature. With increasing temperature reversion rate, the strain to peak stress slightly increased, while the peak stress showed little variation. The evolution of plastic modulus and strain to peak stress of austenite with varying temperature was in line with the theoretical prediction on Fe.

Managing Reverse Logistics or Reversing Logistics Management?

NARCIS (Netherlands)

M.P. de Brito (Marisa)

2004-01-01

textabstractIn the past, supply chains were busy fine-tuning the logistics from raw material to the end customer. Today an increasing flow of products is going back in the chain. Thus, companies have to manage reverse logistics as well.This thesis contributes to a better understanding of reverse

Computer modeling of the stalled flow of a rotating cylinder and the reverse magnus effect

Science.gov (United States)

Belotserkovskii, S. M.; Kotovskii, V. N.; Nisht, M. I.; Fedorov, R. M.

1985-02-01

Unsteady stalled flow around a rotating cylinder is investigated in a numerical experiment. Attention is mostly given to the reverse Magnus effect which was discovered in tube experiments at some critical rotational speed of the cylinder.

Extreme concentration fluctuations due to local reversibility of mixing in turbulent flows

Science.gov (United States)

Xia, Hua; Francois, Nicolas; Punzmann, Horst; Szewc, Kamil; Shats, Michael

2018-05-01

Mixing of a passive scalar in a fluid (e.g. a radioactive spill in the ocean) is the irreversible process towards homogeneous distribution of a substance. In a moving fluid, due to the chaotic advection [H. Aref, J. Fluid Mech. 143 (1984) 1; J. M. Ottino, The Kinematics of Mixing: Stretching,Chaos and Transport (Cambridge University Press, Cambridge, 1989)] mixing is much faster than if driven by molecular diffusion only. Turbulence is known as the most efficient mixing flow [B. I. Shraiman and E. D. Siggia, Nature 405 (2000) 639]. We show that in contrast to spatially periodic flows, two-dimensional turbulence exhibits local reversibility in mixing, which leads to the generation of unpredictable strong fluctuations in the scalar concentration. These fluctuations can also be detected from the analysis of the fluid particle trajectories of the underlying flow.

Research on external flow field of a car based on reverse engineering

Science.gov (United States)

Hu, Shushan; Liu, Ronge

2018-05-01

In this paper, the point cloud data of FAW-VOLKSWAGEN car body shape is obtained by three coordinate measuring instrument and laser scanning method. The accurate three dimensional model of the car is obtained using CATIA software reverse modelling technology. The car body is gridded, the calculation field and boundary condition type of the car flow field are determined, and the numerical simulation is carried out in Hyper Mesh software. The pressure cloud diagram, velocity vector diagram, air resistance coefficient and lift coefficient of the car are obtained. The calculation results reflect the aerodynamic characteristics of the car's external flow field. The motion of the separation flow on the surface of the vehicle body is well simulated, and the area where the vortex motion is relatively intense has been determined. The results provide a theoretical basis for improving and optimizing the body shape.

A reverse flow catalytic membrane reactor for the production of syngas: an experimental study

NARCIS (Netherlands)

Smit, J.; Bekink, G.J.; van Sint Annaland, M.; Kuipers, J.A.M.

2005-01-01

In this paper experimental results are presented for a demonstration unit of a recently proposed novel integrated reactor concept (Smit et. al., 2005) for the partial oxidation of natural gas to syngas (POM), namely a Reverse Flow Catalytic Membrane Reactor (RFCMR). Natural gas has great potential

Performance characteristics of axisymmetric venturi-like reverse-flow diverters. Consolidated Fuel Reprocessing Program

International Nuclear Information System (INIS)

Smith, G.V.; Counce, R.M.

1984-01-01

This paper presents experimental and model-predicted pressure-flow characteristics of axisymmetric venturi-like reverse-flow diverters (RFDs), the key component of fluid pumping systems utilized for the transport of hazardous fluids. The effects of several key geometric parameters, operating conditions, and fluid properties on the performance of the RFD are presented and compared to model predictions. The results indicate good agreement between data and theory over a large portion of the range of variables studied. Cavitation is observed to be the primary factor in limiting the performance of the RFD at small values of load impedances

The quantitative visualisation of the flow in a 1/10th scale model thrust reverser at the Aircraft Research Association, Bedford

Science.gov (United States)

Bryanston-Cross, P.; Sale, R.

1992-06-01

A series of laser visualization measurements has been made to both visualize and map the velocity and direction of the transonic flow from a 1/10th scale model of a thrust reverser. The measurements which have been made by injecting micron sized water droplets into the flow, used two techniques to provide a quantitative measurement of the flow field. The first technique LLS (laser light sheet) provided a general view of the flow, whereas a second pulse laser technique PIV (particle image velocimetry) made a specific measurement in the vicinity of the thrust reverser's 'kicker' plate to map the velocity and direction of the exit flow. This successful study is, to the best of the author's knowledge, the first example of a whole field quantitative visualization being achieved in such a turbulent transonic flow.

Occurrence of critical heat flux during blowdown with flow reversal

International Nuclear Information System (INIS)

Leung, J.C.M.

1977-01-01

A small-scale experiment using Freon-11 at 130 0 F (54.4 0 C) and 65 psia (0.45 MPa) in a well-instrumented, transparent annular test section was used to study the occurrence of critical heat flux (CHF) during blowdown with flow reversal. The inner stainless steel tube of the annulus was uniformly heated over its 61-cm length. Inlet and exit void fractions were measured by a capacitance technique. Flow-regime transition was observed with high-speed photography. A 1-hr contact time between Freon-11 and nitrogen at 130 0 F (54.4 0 C) and 60 psig (0.517 MPa) was found to greatly affect the steady-state subcooled-boiling initial conditions. Delay in bubble growth was observed in adiabatic blowdown runs. This was caused by the conditions of thermodynamic nonequilibrium required for the unstable bubble growth. For the diabatic runs, equilibrium was more closely approached in the test section during the early phase of blowdown

New developments in secondary stroke prevention: impact of the European/Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT) on clinical management.

Science.gov (United States)

Lutsep, Helmi L

2007-01-01

Secondary stroke prevention is an important goal of poststroke patient treatment. Various pharmacologic approaches have been advocated, but the relative efficacy and safety of these regimens has remained the subject of much debate. Recently released data from the European/Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT) indicated that combination therapy with aspirin and extended-release dipyridamole was more effective than aspirin monotherapy, and probably more effective than anticoagulants, for the prevention of cerebrovascular events after a stroke or transient ischemic attack. When viewed in light of results of earlier trials, these findings confirmed that combination aspirin plus extended-release dipyridamole therapy improved outcomes in these patients and is a recommended option for poststroke patient treatment.

Plasma-liquid system with reverse vortex flow of 'tornado' type (TORNADO-LE)

International Nuclear Information System (INIS)

Nedybalyuk, O.A.; Chernyak, V.Ya.; Olszewski, S.V.

2010-01-01

The results of experimental investigations of the plasma in plasma-liquid system with reverse vortex flow of 'tornado' type are presented. Volt-ampere characteristic of discharge in the current range from 200 to 400 mA were measured. Emission spectra of plasma in range from 200 to 1100 nm were measured. Excitation temperatures (electronic T e * , vibrational T v * and rotational T r * ) were obtained. Emission spectra of hydroxyl OH were calculated.

A highly reversible anthraquinone-based anolyte for alkaline aqueous redox flow batteries

Science.gov (United States)

Cao, Jianyu; Tao, Meng; Chen, Hongping; Xu, Juan; Chen, Zhidong

2018-05-01

The development of electroactive organic materials for use in aqueous redox flow battery (RFB) electrolytes is highly attractive because of their structural flexibility, low cost and sustainability. Here, we report on a highly reversible anthraquinone-based anolyte (1,8-dihydroxyanthraquinone, 1,8-DHAQ) for alkaline aqueous RFB applications. Electrochemical measurements reveal the substituent position of hydroxyl groups for DHAQ isomers has a significant impact on the redox potential, electrochemical reversibility and water-solubility. 1,8-DHAQ shows the highest redox reversibility and rapidest mass diffusion among five isomeric DHAQs. The alkaline aqueous RFB using 1,8-DHAQ as the anolyte and potassium ferrocyanide as the catholyte yields open-circuit voltage approaching 1.1 V and current efficiency and capacity retention exceeding 99.3% and 99.88% per cycle, respectively. This aqueous RFB produces a maximum power density of 152 mW cm-2 at 100% SOC and 45 °C. Choline hydroxide was used as a hydrotropic agent to enhance the water-solubility of 1,8-DHAQ. 1,8-DHAQ has a maximum solubility of 3 M in 1 M KOH with 4 M choline hydroxide.

Reversible chemical delithiation/lithiation of LiFePO4: towards a redox flow lithium-ion battery.

Science.gov (United States)

Huang, Qizhao; Li, Hong; Grätzel, Michael; Wang, Qing

2013-02-14

Reversible chemical delithiation/lithiation of LiFePO(4) was successfully demonstrated using ferrocene derivatives, based on which a novel energy storage system--the redox flow lithium-ion battery (RFLB), was devised by integrating the operation flexibility of a redox flow battery and high energy density of a lithium-ion battery. Distinct from the recent semi-solid lithium rechargeable flow battery, the energy storage materials of RFLB stored in separate energy tanks remain stationary upon operation, giving us a fresh perspective on building large-scale energy storage systems with higher energy density and improved safety.

Effect of Flow Channel Shape on Performance in Reverse Electrodialysis

Energy Technology Data Exchange (ETDEWEB)

Kwon, Kilsung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Deok Han; Kim, Daejoong [Sogang Univ., Seoul (Korea, Republic of)

2017-05-15

Reverse electrodialysis (RED), which generates electrical energy from the difference in concentration of two solutions, has been actively studied owing to its high potential and the increased interest in renewable energy resulting from the Paris Agreement on climate change. For RED commercialization, its power density needs to be maximized, and therefore various methods have been discussed. In this paper, the power density was measured using various flow shapes based on the aspect ratio, opening ratio, and number of distribution channels. We found that the power density is enhanced with a decrease in the aspect ratio and an increase in the opening ratio and number of distribution channels.

Device for preventing cooling water from flowing out of reactor

International Nuclear Information System (INIS)

Chinen, Masanori; Kotani, Koichi; Murase, Michio.

1976-01-01

Object: To provide emergency cooling system, which can prevent cooling water bearing radioactivity from flowing to the outside of the reactor at the time of breakage of feedwater pipe, thus eliminating the possibility of exposure of the fuel rod to provide high reliability and also reducing the possibility of causing radioactive pollution. Structure: The device for preventing cooling water from flowing out from the reactor features a jet nozzle inserted in a feedwater pipe adjacent to the inlet or outlet thereof immediately before the reactor container. The nozzle outlet is provided in the vicinity of the reactor wall and in a direction opposite to the direction of out-flow, and water supplied from a high pressure pump is jetted from it. (Nakamura, S.)

Turbulence, transport, and zonal flows in the Madison symmetric torus reversed-field pinch

Science.gov (United States)

Williams, Z. R.; Pueschel, M. J.; Terry, P. W.; Hauff, T.

2017-12-01

The robustness and the effect of zonal flows in trapped electron mode (TEM) turbulence and Ion Temperature Gradient (ITG) turbulence in the reversed-field pinch (RFP) are investigated from numerical solutions of the gyrokinetic equations with and without magnetic external perturbations introduced to model tearing modes. For simulations without external magnetic field perturbations, zonal flows produce a much larger reduction of transport for the density-gradient-driven TEM turbulence than they do for the ITG turbulence. Zonal flows are studied in detail to understand the nature of their strong excitation in the RFP and to gain insight into the key differences between the TEM- and ITG-driven regimes. The zonal flow residuals are significantly larger in the RFP than in tokamak geometry due to the low safety factor. Collisionality is seen to play a significant role in the TEM zonal flow regulation through the different responses of the linear growth rate and the size of the Dimits shift to collisionality, while affecting the ITG only minimally. A secondary instability analysis reveals that the TEM turbulence drives zonal flows at a rate that is twice that of the ITG turbulence. In addition to interfering with zonal flows, the magnetic perturbations are found to obviate an energy scaling relation for fast particles.

Safety analysis of switching between reductive and oxidative conditions in a reaction coupling reverse flow reactor.

NARCIS (Netherlands)

van Sint Annaland, M.; Kuipers, J.A.M.; van Swaaij, Willibrordus Petrus Maria

2001-01-01

A new reverse flow reactor is developed where endothermic reactants (propane dehydrogenation) and exothermic reactants (fuel combustion) are fed sequentially to a monolithic catalyst, while periodically alternating the inlet and outlet positions. Upon switching from reductive to oxidative conditions

Reverse radiometric flow injection analysis (RFIA) of radioactive waste-waters with an ASIA (Ismatec) analyzer

Energy Technology Data Exchange (ETDEWEB)

Myint, U; Win, N; San, K; Han, B; Myoe, K M [Yangon Univ. (Myanmar). Dept. of Chemistry; Toelgyessy, J [Slovak Technical Univ., Bratislava (Slovakia). Dept. of Environmental Science

1994-07-01

A new application of reverse radiometric flow injection analysis is described. RFIA was used for the analysis of radioactive wastewaters. ASIA (Ismatec) analyzer with NaI(Tl) scintillation detector was used in the study of analysis of [sup 131]I containing waste-aster. (author) 4 refs.; 3 figs.

Combining or Separating Forward and Reverse Logistics

DEFF Research Database (Denmark)

Herbert-Hansen, Zaza Nadja Lee; Larsen, Samuel; Nielsen, Anders

2018-01-01

Purpose – While forward logistics handles and manages the flow of goods downstream in the supply chain from suppliers to customers, reverse logistics (RL) manages the flow of returned goods upstream. A firm can combine reverse logistics with forward logistics, keep the flows separated, or choose......-research addresses intra-RL issues while the relationship between forward and reverse logistics is under-researched. This paper contributes to RL-theory by identifying the contextual factors that determine the most advantageous relationship between forward and reverse logistics, and proposes a novel decision making...

Evolving uses of oral reverse transcriptase inhibitors in the HIV-1 epidemic: From treatment to prevention

NARCIS (Netherlands)

R.K. Gupta (Ravindra); D.A.M.C. van de Vijver (David); S. Manicklal (Sheetal); M.A. Wainberg (Mark)

2013-01-01

textabstractThe HIV epidemic continues unabated, with no highly effective vaccine and no cure. Each new infection has significant economic, social and human costs and prevention efforts are now as great a priority as global antiretroviral therapy (ART) scale up. Reverse transcriptase inhibitors, the

Comparative study between two animal models of extrapyramidal movement disorders: prevention and reversion by pecan nut shell aqueous extract.

Science.gov (United States)

Trevizol, Fabiola; Benvegnú, Dalila M; Barcelos, Raquel C S; Pase, Camila S; Segat, Hecson J; Dias, Verônica Tironi; Dolci, Geisa S; Boufleur, Nardeli; Reckziegel, Patrícia; Bürger, Marilise E

2011-08-01

Acute reserpine and subchronic haloperidol are animal models of extrapyramidal disorders often used to study parkinsonism, akinesia and tardive dyskinesia. In humans, these usually irreversible and disabling extrapyramidal disorders are developed by typical antipsychotic treatment, whose pathophysiology has been related to oxidative damages development. So far, there is no treatment to prevent these problems of the psychiatric clinic, and therefore further studies are needed. Here we used the animal models of extrapyramidal disorders cited above, which were performed in two distinct experiments: orofacial dyskinesia (OD)/catalepsy induced by acute reserpine and subchronic haloperidol after (experiment 1) and before (experiment 2) oral treatment with pecan shell aqueous extract (AE), a natural and promissory antioxidant. When administered previously (exp.1), the AE prevented OD and catalepsy induced by both reserpine and haloperidol. When reserpine and haloperidol were administered before the extract (exp.2), the animals developed OD and catalepsy all the same. However, the orofacial parameter (but not catalepsy) in both animal models was reversed after 7 and 14 days of AE treatment. These results indicate that, acute reserpine and subchronic haloperidol administrations induced similar motor disorders, although through different mechanisms, and therefore are important animal models to study the physiopathology of extrapyramidal disorders. Comparatively, the pecan shell AE was able to both prevent and reverse OD but only to prevent catalepsy. These results reinforce the role of oxidative stress and validate the two animal models used here. Our findings also favor the idea of prevention of extrapyramidal disorders, rather than their reversal. Copyright © 2011 Elsevier B.V. All rights reserved.

A functional language for describing reversible logic

DEFF Research Database (Denmark)

Thomsen, Michael Kirkedal

2012-01-01

Reversible logic is a computational model where all gates are logically reversible and combined in circuits such that no values are lost or duplicated. This paper presents a novel functional language that is designed to describe only reversible logic circuits. The language includes high....... Reversibility of descriptions is guaranteed with a type system based on linear types. The language is applied to three examples of reversible computations (ALU, linear cosine transformation, and binary adder). The paper also outlines a design flow that ensures garbage- free translation to reversible logic...... circuits. The flow relies on a reversible combinator language as an intermediate language....

Clofibrate prevents and reverses the hemodynamic manifestations of hyperthyroidism in rats.

Science.gov (United States)

Rodríguez-Gómez, Isabel; Cruz, Antonio; Moreno, Juan Manuel; Soler, Agatángelo; Osuna, Antonio; Vargas, Félix

2008-03-01

This study analyzed the effects of the chronic administration of clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on the development and established hemodynamic, morphologic, metabolic, and renal manifestations of hyperthyroidism in rats. The prevention study used four groups of male Wistar rats: control, clofibrate (240 mg/kg/day by gavage), T(4)(75 microg thyroxine/rat/day s.c.), and T(4)+clofibrate. All treatments were maintained for 3 weeks. Body weight (BW), tail systolic blood pressure (SBP), and heart rate (HR) were recorded weekly. Finally, temperature, SBP, pulse pressure (PP) and HR were recorded in conscious rats, and morphologic, metabolic, plasma, and renal variables were measured. The reversion study used two groups of rats, T(4)(treated for 6 weeks) and T(4)+clofibrate, measuring their hemodynamic variables and temperature for 3 weeks. T(4) increased BP, HR, PP, and temperature when compared with control rats. Clofibrate prevented and reversed the increase in SBP, HR, PP, and temperature produced by T(4) administration, reduced plasma thyroid hormone levels, and increased plasma thyroid-stimulating hormone values and phenol-uridine diphosphate-glucuronosyl-transferase (UGT) activity. However, clofibrate did not modify the cardiac or renal hypertrophy, polyphagia, polydipsia, or proteinuria of hyperthyroid rats. In normal rats, clofibrate treatment did not significantly change thyroid hormone levels, phenol-UGT activity, or any hemodynamic, morphologic, or renal variables. Chronic clofibrate treatment suppressed the hemodynamic manifestations and increased temperature of hyperthyroidism, an effect that can be produced by direct antithyroid effects. However, clofibrate administration did not modify the morphologic, metabolic, or renal alterations of hyperthyroid rats, indicating specificity in the antithyroid actions of clofibrate.

High Pressure Reverse Flow APS Engine

Science.gov (United States)

Senneff, J. M.

1972-01-01

A design and test demonstration effort was undertaken to evaluate the concept of the reverse flow engine for the APS engine application. The 1500 lb (6672 N) thrust engine was designed to operate on gaseous hydrogen and gaseous oxygen propellants at a mixture ratio of 4 and to achieve the objective performance of 435 sec (4266 Nsec/kg) specific impulse. Superimposed durability requirements called for a million-cycle capability with 50 hours duration. The program was undertaken as a series of tasks including the initial preliminary design, design of critical test components and finally, the design and demonstration of an altitude engine which could be used interchangeably to examine operating parameters as well as to demonstrate the capability of the concept. The program results are reported with data to indicate that all of the program objectives were met or exceeded within the course of testing on the program. The analysis effort undertaken is also reported in detail and supplemented with test data in some cases where prior definitions could not be made. The results are contained of these analyses as well as the test results conducted throughout the course of the program. Finally, the test data and analytical results were combined to allow recommendations for a flight weight design. This preliminary design effort is also detailed.

INVESTIGATION RESULTS PERTAINING TO DETERMINATION OF REVERSE FLOW PRESSURE ON TREATED FLAT SURFACE

Directory of Open Access Journals (Sweden)

A. N. Zhuk

2018-01-01

Full Text Available The executed investigations have shown that it is possible to prepare sheet-like material for laser cutting economically viable and with small amount of power expenditure while using reverse jet cleaning for surface treatment. As compared to conventional jet cleaning technologies efficiency of the reverse jet cleaning is attributed to significant pressure increase (by 25–50 % when the jet is interacting with the treated surface. The paper proposes a mathematical model on the basis of approximate energy method (upper-bound method and the model is used for calculation of fracture pressure due to action of the reverse jet on the treated surface which consists of a corrosion deposit layer. A variational problem was solved within a framework of the developed model and the problem solution has made it possible to obtain a theoretical dependence for calculation of minimum fracture pressure value pmin in the point reverse jet impact with a barrier oretical dependence and it has taken into account yielding point of the deformed material ss, density of fractured material med material r, jet velocity uстр and parameter of reverse flowing – jet reduction ratio l. Comparison theoretical data and experimental ones (experimental data have been obtained while using a differential pressure transducer ЭДП-30 and a spring dynamometer with measuring limits 25 and 80 MPa, respectively has shown difference by 4–15 %. Determined insignificant difference between a theory and an experiment demonstrates that the obtained theoretical dependence is considered as a quite correct one and it can be used in engineering practice for prediction of power and kinematics parameters which are necessary for selection of the required pump equipment designed for realization of reverse-jet cleaning process.

Joint interpretation of two tracer tests with reversed flow fields

International Nuclear Information System (INIS)

Kunstmann, H.; Kinzelbach, W.; Marschall, P.; Li, G.

1995-01-01

Two dipole tracer experiments were performed in a fractured rock at the Grimsel Test Site in February/March 1993. In both experiments NaCl was used as a tracer. The extraction rate was twice the injection rate. In the second experiment injection and extraction were interchanged (Reverse-Experiment). Long tailing was characteristic for the breakthrough curves in both experiments. The tests were interpreted using a single fracture flow model. Tracer transport is described by advection/dispersion along the fracture allowing for diffusion into an immobile matrix. The authors were able to interpret the breakthrough curves for both experiments by one unique set of parameters, describing transport and baseflow. Uniqueness could only be achieved when using the information of both experiments. The authors conclude that performing a Reverse-Experiment is an indispensable tool for parameter identification in dipole tracer tests. A sensitivity analysis suggested that not only matrix diffusion is responsible for the tailing in the breakthrough curves but also transversal dispersivity. Further, the typical exchange time between mobile and immobile media was too small to be attributed to matrix diffusion in the strict sense which will cause tailing even at large spatial and temporal scales. Analysis of the covariance matrices showed that the parameters have small errors but high correlation

Issues in measure-preserving three dimensional flow integrators: Self-adjointness, reversibility, and non-uniform time stepping

International Nuclear Information System (INIS)

Finn, John M.

2015-01-01

Properties of integration schemes for solenoidal fields in three dimensions are studied, with a focus on integrating magnetic field lines in a plasma using adaptive time stepping. It is shown that implicit midpoint (IM) and a scheme we call three-dimensional leapfrog (LF) can do a good job (in the sense of preserving KAM tori) of integrating fields that are reversible, or (for LF) have a “special divergence-free” (SDF) property. We review the notion of a self-adjoint scheme, showing that such schemes are at least second order accurate and can always be formed by composing an arbitrary scheme with its adjoint. We also review the concept of reversibility, showing that a reversible but not exactly volume-preserving scheme can lead to a fractal invariant measure in a chaotic region, although this property may not often be observable. We also show numerical results indicating that the IM and LF schemes can fail to preserve KAM tori when the reversibility property (and the SDF property for LF) of the field is broken. We discuss extensions to measure preserving flows, the integration of magnetic field lines in a plasma and the integration of rays for several plasma waves. The main new result of this paper relates to non-uniform time stepping for volume-preserving flows. We investigate two potential schemes, both based on the general method of Feng and Shang [Numer. Math. 71, 451 (1995)], in which the flow is integrated in split time steps, each Hamiltonian in two dimensions. The first scheme is an extension of the method of extended phase space, a well-proven method of symplectic integration with non-uniform time steps. This method is found not to work, and an explanation is given. The second method investigated is a method based on transformation to canonical variables for the two split-step Hamiltonian systems. This method, which is related to the method of non-canonical generating functions of Richardson and Finn [Plasma Phys. Controlled Fusion 54, 014004 (2012

Energetic atomic and molecular ions of ionospheric origin observed in distant magnetotail flow-reversal events

Science.gov (United States)

Christon, S. P.; Gloeckler, G.; Williams, D. J.; Mukai, T.; Mcentire, R. W.; Jacquey, C.; Angelopoulos, V.; Lui, A. T. Y.; Kokubun, S.; Fairfield, D. H.

1994-01-01

Energetic atomic (O(+1) and N(+1)) and molecular (O2(+1), NO(+1), and N2(+1)) ions of ionospheric origin were observed in Earth's magnetotail at X approximately -146 R(sub E) during two plasma sheet sunward/tailward flow-reversal events measured by instruments on the GEOTAIL spacecraft. These events were associated with concurrent ground-measured geomagnetic disturbance intensification at auroral-and mid-latitudes (Kp = 7(-)). Energetic ions in the sunward-component and tailward flows were from both the solar wind and ionosphere. Plasma and energetic ions participated in the flows. During tailward flow, ionospheric origin ion abundance ratios at approximately 200-900 km/s in the rest frame were N(+1)/O(+1) = approximately 25-30% and ((O2(+1), NO(+1), and N2(+1))/O(+1) = approximately 1-2%. We argue that tailward flow most likely initiated approximately 80-100 R(sub E) tailward of Earth and molecular ions were in the plasma sheet prior to geomagnetic intensification onset.

Analysis of the Numerical Modelling of Turbulence in the Conical Reverse-Flow Cyclone

Directory of Open Access Journals (Sweden)

Inga Jakštonienė

2011-02-01

Full Text Available The paper describes the numerical modelling of the swirling fluid flow in the Stairmand cyclone (conical reverse-flow – CRF with tangential inlet (equipment for separating solid particles from the gaseous fluid flow. A review of experimental and theoretical papers is conducted introducing three-dimen­sional differential equations for transfer processes. The numerical modelling of the Stairmand cyclone the height of which is 0.75 m, diameter – 0.17 m, the height of a cylindrical part – 0.290 m, a conical part – 0,39 m and an inlet area is 0,085×0,032 m is presented. When governing three-dimensional fluid flow, transfer equations Navje-Stokes and Reynolds are solved using the finite volume method in a body-fitted co-ordinate system using standard k– e and RNG k– e model of turbulence. Modelling is realised for inlet velocity 4.64, 9.0 and 14.8 m/s (flow rate was 0.0112, 0.0245 and 0.0388 m3/s. The results obtained from the numerical tests have demonstrated that the RNG k– e model of turbulence yields a reasonably good prediction for highly swirling flows in cyclones: the presented numerical results (tangential and radial velocity profiles are compared with numerical and experimental data obtained by other authors. The mean relative error of ± 7,5% is found. Keywords: cyclone, solid particles, numerical modelling, turbulence, one-phase flow.DOI: 10.3846/mla.2010.085

Behavioural treatment of tics: habit reversal and exposure with response prevention.

Science.gov (United States)

van de Griendt, J M T M; Verdellen, C W J; van Dijk, M K; Verbraak, M J P M

2013-07-01

Behaviour therapy has been shown to be an effective strategy in treating tics; both habit reversal (HR) and exposure and response prevention (ER) are recommended as first-line interventions. This review provides an overview of the history, theoretical concepts and evidence at present for HR and ER. In addition, treatment manuals for HR and ER are described. Despite the evidence and availability of treatment manuals, many patients do not receive a first-line psychological intervention for tics. Barriers to the acceptance and dissemination of behaviour therapy are discussed as are ways to overcome these barriers, such as the use of E-health and E-learning. Copyright © 2012 Elsevier Ltd. All rights reserved.

The effect of flow and chemical corrosion in reverse osmosis over desalinated water

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Jae [Chunnam National Univ., Gwangju (Korea, Republic of); Pak, Byung Gu [Doosan Heavy Industry Co., Tongyoung (Korea, Republic of)

2015-12-15

Desalinated water produced by a reverse osmosis (RO) filtering method forms about 22% of total production of desalinated water in the world. However, the RO environment is very corrosive due to the presence of various chemicals for water treatment and the flow of sand particles leading to corrosion. Recently, there has been much effort to substitute cheaper and more corrosion resistant stainless steels for copper based alloys as a valve material in RO. Nevertheless, the effects of chemicals and particles on the corrosion of stainless steels have rarely been studied. Erosion phenomenon was detected under the condition with the flow rate of more than 8ms{sup -1} in spite of the absence of sand particles. In seawater containing sand particles, the erosion in stainless steels was accelerated further.

Stent revascularization restores cortical blood flow and reverses tissue hypoxia in atherosclerotic renal artery stenosis but fails to reverse inflammatory pathways or glomerular filtration rate.

Science.gov (United States)

Saad, Ahmed; Herrmann, Sandra M S; Crane, John; Glockner, James F; McKusick, Michael A; Misra, Sanjay; Eirin, Alfonso; Ebrahimi, Behzad; Lerman, Lilach O; Textor, Stephen C

2013-08-01

Atherosclerotic renal artery stenosis (ARAS) is known to reduce renal blood flow, glomerular filtration rate (GFR) and amplify kidney hypoxia, but the relationships between these factors and tubulointerstitial injury in the poststenotic kidney are poorly understood. The purpose of this study was to examine the effect of renal revascularization in ARAS on renal tissue hypoxia and renal injury. Inpatient studies were performed in patients with ARAS (n=17; >60% occlusion) before and 3 months after stent revascularization, or in patients with essential hypertension (n=32), during fixed Na(+) intake and angiotensin converting enzyme/angiotensin receptors blockers Rx. Single kidney cortical, medullary perfusion, and renal blood flow were measured using multidetector computed tomography, and GFR by iothalamate clearance. Tissue deoxyhemoglobin levels (R(2)*) were measured by blood oxygen level-dependent MRI at 3T, as was fractional kidney hypoxia (percentage of axial area with R(2)*>30/s). In addition, we measured renal vein levels of neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and tumor necrosis factor-α. Pre-stent single kidney renal blood flow, perfusion, and GFR were reduced in the poststenotic kidney. Renal vein neutrophil gelatinase-associated lipocalin, tumor necrosis factor-α, monocyte chemoattractant protein-1, and fractional hypoxia were higher in untreated ARAS than in essential hypertension. After stent revascularization, fractional hypoxia fell (Pblood flow, whereas GFR and neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, and tumor necrosis factor-α remained unchanged. These data demonstrate that despite reversal of renal hypoxia and partial restoration of renal blood flow after revascularization, inflammatory cytokines and injury biomarkers remained elevated and GFR failed to recover in ARAS. Restoration of vessel patency alone failed to reverse tubulointerstitial damage and partly

Operation of a catalytic reverse flow reactor for the purification of air contamined with volatile organic compounds

NARCIS (Netherlands)

van de Beld, L.; van de Beld, L.; Westerterp, K.R.

1997-01-01

Catalytic oxidation in a reverse flow reactor is an attractive process for the decontamination of air polluted with volatile organic compounds (VOCs). In this paper several aspects of operating this type of reactor for air purification under strongly varying conditions will be discussed. For a

Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels

NARCIS (Netherlands)

Heinen, André; Aldakkak, Mohammed; Stowe, David F.; Rhodes, Samhita S.; Riess, Matthias L.; Varadarajan, Srinivasan G.; Camara, Amadou K. S.

2007-01-01

Mitochondria generate reactive oxygen species (ROS) dependent on substrate conditions, O(2) concentration, redox state, and activity of the mitochondrial complexes. It is well known that the FADH(2)-linked substrate succinate induces reverse electron flow to complex I of the electron transport chain

Entropy production in a cell and reversal of entropy flow as an anticancer therapy

Institute of Scientific and Technical Information of China (English)

Liao-fu LUO

2009-01-01

The entropy production rate of cancer cells is always higher than healthy cells in the case where no external field is applied. Different entropy production between two kinds of cells determines the direction of entropy flow among cells. The entropy flow is the carrier of information flow. The entropy flow from cancerous cells to healthy cells takes along the harmful information of cancerous cells, propagating its toxic action to healthy tissues. We demonstrate that a low-frequency and low- intensity electromagnetic field or ultrasound irradiation may increase the entropy production rate of a cell in normal tissue than that in cancer and consequently re- verse the direction of entropy current between two kinds of cells. The modification of the PH value of cells may also cause the reversal of the direction of entropy flow between healthy and cancerous cells. Therefore, the bio- logical tissue under the irradiation of an electromagnetic field or ultrasound or under the appropriate change of cell acidity can avoid the propagation of harmful infor- marion from cancer cells. We suggest that this entropy mechanism possibly provides a basis for a novel approach to anticancer therapy.

The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells.

Science.gov (United States)

Froldi, Francesca; Szuperak, Milan; Weng, Chen-Fang; Shi, Wei; Papenfuss, Anthony T; Cheng, Louise Y

2015-01-15

Cellular dedifferentiation is the regression of a cell from a specialized state to a more multipotent state and is implicated in cancer. However, the transcriptional network that prevents differentiated cells from reacquiring stem cell fate is so far unclear. Neuroblasts (NBs), the Drosophila neural stem cells, are a model for the regulation of stem cell self-renewal and differentiation. Here we show that the Drosophila zinc finger transcription factor Nervous fingers 1 (Nerfin-1) locks neurons into differentiation, preventing their reversion into NBs. Following Prospero-dependent neuronal specification in the ganglion mother cell (GMC), a Nerfin-1-specific transcriptional program maintains differentiation in the post-mitotic neurons. The loss of Nerfin-1 causes reversion to multipotency and results in tumors in several neural lineages. Both the onset and rate of neuronal dedifferentiation in nerfin-1 mutant lineages are dependent on Myc- and target of rapamycin (Tor)-mediated cellular growth. In addition, Nerfin-1 is required for NB differentiation at the end of neurogenesis. RNA sequencing (RNA-seq) and chromatin immunoprecipitation (ChIP) analysis show that Nerfin-1 administers its function by repression of self-renewing-specific and activation of differentiation-specific genes. Our findings support the model of bidirectional interconvertibility between neural stem cells and their post-mitotic progeny and highlight the importance of the Nerfin-1-regulated transcriptional program in neuronal maintenance. © 2015 Froldi et al.; Published by Cold Spring Harbor Laboratory Press.

Edge topology and flows in the reversed-field pinch

International Nuclear Information System (INIS)

Spizzo, G.; Agostini, M.; Scarin, P.; Vianello, N.; Cappello, S.; Puiatti, M. E.; Valisa, M.; White, R. B.

2012-01-01

Edge topology and plasma flow deeply influence transport in the reversed-field pinch as well as in all fusion devices, playing an important role in many practical aspects of plasma performance, such as access to enhanced confinement regimes, the impact on global power balance and operative limits, such as the density limit (Spizzo G. et al 2010 Plasma Phys. Control. Fusion 52 095011). A central role is played by the edge electric field, which is determined by the ambipolar constraint guaranteeing quasi-neutrality in a sheath next to the plasma wall. Its radial component is experimentally determined in RFX over the whole toroidal angle by means of a diagnostic set measuring edge plasma potential and flow with different techniques (Scarin P. et al 2011 Nucl. Fusion 51 073002). The measured radial electric field is used to construct the potential in the form Φ(ψ p , θ, ζ) (ψ p radial coordinate, θ, ζ angles), by means of the Hamiltonian guiding-centre code ORBIT. Simulations show that a proper functional form of the potential can balance the differential radial diffusion of electrons and ions subject to m = 0 magnetic island O- and X-points. Electrons spend more time in the X-points of such islands than in O-points; ions have comparatively larger drifts and their radial motion is more uniform over the toroidal angle. The final spatial distribution of Φ(ψ p , θ, ζ) results in a complex 3D pattern, with convective cells next to the wall. Generally speaking, an edge topology dominating parallel transport with a given symmetry brings about an edge potential with the same symmetry. This fact helps us to build a first step of a unified picture of the effect of magnetic topology on the Greenwald limit, and, more generally, on flows in the edge of RFPs and tokamaks. (paper)

ExB flow shear and enhanced confinement in the Madison Symmetric Torus reversed-field pinch

International Nuclear Information System (INIS)

Chapman, B.E.; Almagri, A.F.; Anderson, J.K.; Chiang, C.; Craig, D.; Fiksel, G.; Lanier, N.E.; Prager, S.C.; Sarff, J.S.; Stoneking, M.R.; Terry, P.W.

1998-01-01

Strong ExB flow shear occurs in the edge of three types of enhanced confinement discharge in the Madison Symmetric Torus [Dexter et al., Fusion Technol. 19, 131 (1991)] reversed-field pinch. Measurements in standard (low confinement) discharges indicate that global magnetic fluctuations drive particle and energy transport in the plasma core, while electrostatic fluctuations drive particle transport in the plasma edge. This paper explores possible contributions of ExB flow shear to the reduction of both the magnetic and electrostatic fluctuations and, thus, the improved confinement. In one case, shear in the ExB flow occurs when the edge plasma is biased. Biased discharges exhibit changes in the edge electrostatic fluctuations and improved particle confinement. In two other cases, the flow shear emerges (1) when auxiliary current is driven in the edge and (2) spontaneously, following sawtooth crashes. Both edge electrostatic and global magnetic fluctuations are reduced in these discharges, and both particle and energy confinement improve. copyright 1998 American Institute of Physics

Feasibility study of a reverse flow catalytic membrane reactor with porous membranes for the production of syngas

NARCIS (Netherlands)

Smit, J.; van Sint Annaland, M.; Kuipers, J.A.M.

2005-01-01

In this paper a novel reverse flow catalytic membrane reactor (RFCMR) is proposed for the partial oxidation of CH4 to syngas. The feasibility of the RFCMR concept has been investigated for industrial conditions on basis of a simulation study employing a reactor model, which includes a detailed

Spontaneous generation and reversals of mean flows in a convectively-generated internal gravity wave field

Science.gov (United States)

Couston, Louis-Alexandre; Lecoanet, Daniel; Favier, Benjamin; Le Bars, Michael

2017-11-01

We investigate via direct numerical simulations the spontaneous generation and reversals of mean zonal flows in a stably-stratified fluid layer lying above a turbulent convective fluid. Contrary to the leading idealized theories of mean flow generation by self-interacting internal waves, the emergence of a mean flow in a convectively-generated internal gravity wave field is not always possible because nonlinear interactions of waves of different frequencies can disrupt the mean flow generation mechanism. Strong mean flows thus emerge when the divergence of the Reynolds stress resulting from the nonlinear interactions of internal waves produces a strong enough anti-diffusive acceleration for the mean flow, which, as we will demonstrate, is the case when the Prandtl number is sufficiently low, or when the energy input into the internal wavefield by the convection and density stratification are sufficiently large. Implications for mean zonal flow production as observed in the equatorial stratospheres of the Earth, Saturn and Jupiter, and possibly occurring in other geophysical systems such as planetary and stellar interiors will be briefly discussed. Funding provided by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program through Grant Agreement No. 681835-FLUDYCO-ERC-2015-CoG.

How decision reversibility affects motivation.

Science.gov (United States)

Bullens, Lottie; van Harreveld, Frenk; Förster, Jens; Higgins, Tory E

2014-04-01

The present research examined how decision reversibility can affect motivation. On the basis of extant findings, it was suggested that 1 way it could affect motivation would be to strengthen different regulatory foci, with reversible decision making, compared to irreversible decision making, strengthening prevention-related motivation relatively more than promotion-related motivation. If so, then decision reversibility should have effects associated with the relative differences between prevention and promotion motivation. In 5 studies, we manipulated the reversibility of a decision and used different indicators of regulatory focus motivation to test these predictions. Specifically, Study 1 tested for differences in participants' preference for approach versus avoidance strategies toward a desired end state. In Study 2, we used speed and accuracy performance as indicators of participants' regulatory motivation, and in Study 3, we measured global versus local reaction time performance. In Study 4, we approached the research question in a different way, making use of the value-from-fit hypothesis (Higgins, 2000, 2002). We tested whether a fit between chronic regulatory focus and focus induced by the reversibility of the decision increased participants' subjective positive feelings about the decision outcome. Finally, in Study 5, we tested whether regulatory motivation, induced by decision reversibility, also influenced participants' preference in specific product features. The results generally support our hypothesis showing that, compared to irreversible decisions, reversible decisions strengthen a prevention focus more than a promotion focus. Implications for research on decision making are discussed.

A Typology of Reverse Innovation

DEFF Research Database (Denmark)

von Zedtwitz, Max; Corsi, Simone; Søberg, Peder Veng

2015-01-01

secondary market introduction, this study expands the espoused definition of reverse innovation beyond its market-introduction focus with reversals in the flow of innovation in the ideation and product development phases. Recognizing that each phase can take place in different geographical locations...... taking place in an emerging country. This analytical framework allows recasting of current research at the intersection between innovation and international business. Of the 10 reverse innovation flows, six are new and have not been covered in the literature to date. The study addresses questions......’s portfolio of global innovation competence and capability. The implications for management are concerned with internal and external resistance to reverse innovation. Most significantly, while greater recognition and power of innovation in formerly subordinate organizational units is inconvenient to some...

Reverse stream flow routing by using Muskingum models

Indian Academy of Sciences (India)

Reverse stream flow routing is a procedure that determines the upstream hydrograph given the downstream hydrograph. This paper presents the development of methodology for Muskingum models parameter estimation for reverse stream flow routing. The standard application of the Muskingum models involves calibration ...

Memory-induced sign reversals of the spatial cross-correlation for particles in viscoelastic shear flows

International Nuclear Information System (INIS)

Sauga, Ako; Laas, Katrin; Mankin, Romi

2015-01-01

Highlights: • Cross-correlation (CC) of coordinates of particles in viscoelastic shear flows is discussed. • Expressions for CC functions subjected to both internal and external noises are presented. • Impact of internal and external noises on CC functions are compared. • Memory-induced reentrant sign reversals of the spatial cross-moment are established. - Abstract: The behavior of shear-induced cross-correlation functions between particle fluctuations along orthogonal directions in the shear plane for harmonically trapped Brownian particles in a viscoelastic shear flow is studied. A generalized Langevin equation with a power-law-type memory kernel is used to model the complex structure of the viscoelastic media. Interaction with fluctuations of environmental parameters is modeled by a multiplicative white Gaussian noise, by an internal fractional Gaussian noise, and by an additive external white noise. It is shown that the presence of a memory has a profound effect on the behavior of the cross-correlation functions. Particularly, memory-induced reentrant sign reversals of the spatial cross-moment between orthogonal random displacements of a particle are established, i.e., an increase of the memory exponent can cause the sign reversal from positive to negative, but by a further increase of the memory exponent a reentrant transition from negative to positive values appears. Similarities and differences between the behavior of the models with additive internal and external noises are considered. It is shown that additive external and internal noises cause qualitatively different dependencies of the cross-correlation functions on the time lag. The occurrence of energetic instability due to the influence of multiplicative noise is also discussed.

Reversal permanent charge and reversal potential: case studies via classical Poisson–Nernst–Planck models

International Nuclear Information System (INIS)

Eisenberg, Bob; Liu, Weishi; Xu, Hongguo

2015-01-01

In this work, we are interested in effects of a simple profile of permanent charges on ionic flows. We determine when a permanent charge produces current reversal. We adopt the classical Poisson–Nernst–Planck (PNP) models of ionic flows for this study. The starting point of our analysis is the recently developed geometric singular perturbation approach for PNP models. Under the setting in the paper for case studies, we are able to identify a single governing equation for the existence and the value of the permanent charge for a current reversal. A number of interesting features are established. The related topic on reversal potential can be viewed as a dual problem and is briefly examined in this work too. (paper)

Integration of continuous-flow sampling with microchip electrophoresis using poly(dimethylsiloxane)-based valves in a reversibly sealed device.

Science.gov (United States)

Li, Michelle W; Martin, R Scott

2007-07-01

Here we describe a reversibly sealed microchip device that incorporates poly(dimethylsiloxane) (PDMS)-based valves for the rapid injection of analytes from a continuously flowing stream into a channel network for analysis with microchip electrophoresis. The microchip was reversibly sealed to a PDMS-coated glass substrate and microbore tubing was used for the introduction of gas and fluids to the microchip device. Two pneumatic valves were incorporated into the design and actuated on the order of hundreds of milliseconds, allowing analyte from a continuously flowing sampling stream to be injected into an electrophoresis separation channel. The device was characterized in terms of the valve actuation time and pushback voltage. It was also found that the addition of sodium dodecyl sulfate (SDS) to the buffer system greatly increased the reproducibility of the injection scheme and enabled the analysis of amino acids derivatized with naphthalene-2,3-dicarboxaldehyde/cyanide. Results from continuous injections of a 0.39 nL fluorescein plug into the optimized system showed that the injection process was reproducible (RSD of 0.7%, n = 10). Studies also showed that the device was capable of monitoring off-chip changes in concentration with a device lag time of 90 s. Finally, the ability of the device to rapidly monitor on-chip concentration changes was demonstrated by continually sampling from an analyte plug that was derivatized upstream from the electrophoresis/continuous flow interface. A reversibly sealed device of this type will be useful for the continuous monitoring and analysis of processes that occur either off-chip (such as microdialysis sampling) or on-chip from other integrated functions.

Experimental demonstration of the reverse flow catalytic membrane reactor concept for energy efficient syngas production. Part 2: Model development

NARCIS (Netherlands)

Smit, J.; Bekink, G.J.; Sint Annaland, van M.; Kuipers, J.A.M.

2007-01-01

In this contribution the technical feasibility of the reverse flow catalytic membrane reactor (RFCMR) concept with porous membranes for energy efficient syngas production is investigated. In earlier work an experimental proof of principle was already provided [Smit, J., Bekink, G.J., van Sint

Flow reversal in combined laminar mixed convection heat and mass transfer with phase change in a vertical channel

International Nuclear Information System (INIS)

Oulaid, Othmane; Benhamou, Brahim; Galanis, Nicolas

2010-01-01

This paper, deals with a numerical study of the effects of buoyancy forces on an upward, steady state, laminar flow of humid air in a vertical parallel-plate channel. The plates are wetted by a thin liquid water film and maintained at a constant temperature which is lower than that of the air entering the channel. A 2D fully elliptical model, associated with the Boussinesq assumption, is used to take into account axial diffusion. The solution of this mathematical model is based on the finite volume method and the velocity-pressure coupling is handled by the SIMPLER algorithm. Numerical results show that buoyancy forces have a significant effect on the hydrodynamic, thermal and mass fraction fields. Additionally, these forces induce flow reversal for high air temperatures and mass fractions at the channel entrance. It is established that heat transfer associated with phase change is, sometimes, more significant than sensible heat transfer. Furthermore, this importance depends on the mass fraction gradient. The conditions for the existence of flow reversal are presented in charts and analytical expressions specifying the critical thermal Grashof number as a function of the Reynolds number for different values of the solutal Grashof number and different aspect ratios of the channel.

Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis.

Directory of Open Access Journals (Sweden)

Yuki Kita

Full Text Available BACKGROUND: Optimal treatment for nonalcoholic steatohepatitis (NASH has not yet been established, particularly for individuals without diabetes. We examined the effects of metformin, commonly used to treat patients with type 2 diabetes, on liver pathology in a non-diabetic NASH mouse model. METHODOLOGY/PRINCIPAL FINDINGS: Eight-week-old C57BL/6 mice were fed a methionine- and choline-deficient plus high fat (MCD+HF diet with or without 0.1% metformin for 8 weeks. Co-administration of metformin significantly decreased fasting plasma glucose levels, but did not affect glucose tolerance or peripheral insulin sensitivity. Metformin ameliorated MCD+HF diet-induced hepatic steatosis, inflammation, and fibrosis. Furthermore, metformin significantly reversed hepatic steatosis and inflammation when administered after the development of experimental NASH. CONCLUSIONS/SIGNIFICANCE: These histological changes were accompanied by reduced hepatic triglyceride content, suppressed hepatic stellate cell activation, and the downregulation of genes involved in fatty acid metabolism, inflammation, and fibrogenesis. Metformin prevented and reversed steatosis and inflammation of NASH in an experimental non-diabetic model without affecting peripheral insulin resistance.

Image based measurement techniques for aircraft propeller flow diagnostics : Propeller slipstream investigations at high-lift conditions and thrust reverse

NARCIS (Netherlands)

Roosenboom, E.W.M.

2011-01-01

The aim of the thesis is to measure the propeller slipstream properties (velocity and vorticity) and to assess the unsteady and instantaneous behavior of the propeller flow field at high disk loadings, zero thrust and thrust reverse using the image based measurement techniques. Along with its

END-OF-USE PRODUCTS IN REVERSE LOGISTICS

OpenAIRE

Marta Starostka-Patyk

2007-01-01

Reverse logistics is a very useful tool for enterprises which have to deal with end-of-use products. Forward logistics is not able to manage them, because they show up on the beginning of reverse supply chain. That is the reason for growing importance of reverse flows. Reverse logistics is quite new logistics system. This paper presents the idea of reverse logistics and end-of-use products problems.

Highly efficient reversible addition-fragmentation chain-transfer polymerization in ethanol/water via flow chemistry

Energy Technology Data Exchange (ETDEWEB)

Ye, Piaoran [Case Western Reserve Univ., Cleveland, OH (United States); Cao, Peng -Fei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Su, Zhe [Case Western Reserve Univ., Cleveland, OH (United States); Advincula, Rigoberto [Case Western Reserve Univ., Cleveland, OH (United States)

2017-03-23

Here, utilization of a flow reactor under high pressure allows highly efficient polymer synthesis via reversible addition–fragmentation chain-transfer (RAFT) polymerization in an aqueous system. Compared with the batch reaction, the flow reactor allows the RAFT polymerization to be performed in a high-efficiency manner at the same temperature. The adjustable pressure of the system allows further elevation of the reaction temperature and hence faster polymerization. Other reaction parameters, such as flow rate and initiator concentration, were also well studied to tune the monomer conversion and the molar mass dispersity (Ð) of the obtained polymers. Gel permeation chromatography, nuclear magnetic resonance (NMR), and Fourier transform infrared spectroscopies (FTIR) were utilized to monitor the polymerization process. With the initiator concentration of 0.15 mmol L^–1, polymerization of poly(ethylene glycol) methyl ethermethacrylate with monomer conversion of 52% at 100 °C under 73 bar can be achieved within 40 min with narrow molar mass dispersity (D) Ð (<1.25). The strategy developed here provides a method to produce well-defined polymers via RAFT polymerization with high efficiency in a continuous manner.

Pulmonary Venous Diastolic Flow Reversal and Flash Pulmonary Edema During Management of Ongoing Myocardial Ischemia with Intraaortic Balloon Pump.

Science.gov (United States)

Murray, Davoy; Peng, Yong G

2015-10-15

A 65-year-old man was admitted for acute coronary syndrome with depressed left ventricular function and moderate aortic regurgitation. He was managed with an intraaortic balloon pump for circulatory support before coronary artery bypass grafting and subsequently developed flash pulmonary edema with an associated rare finding of diastolic pulmonary venous flow reversal. In this report, we provide a review of intraaortic balloon pump use in current clinical practice and elaborate on the pathophysiology of an uncommon pulmonary venous flow pattern found in our patient.

THEORETICAL FRAMES FOR DESIGNING REVERSE LOGISTICS PROCESSES

OpenAIRE

Janusz K. Grabara; Sebastian Kot

2009-01-01

Logistics processes of return flow became more and more important in present business practice. Because of better customer satisfaction, environmental and financial aspects many enterprises deal with reverse logistics performance. The paper is a literature review focused on the design principles of reverse logistics processes Keywords: reverse logistics, designing.

Reverse logistics in the Brazilian construction industry.

Science.gov (United States)

Nunes, K R A; Mahler, C F; Valle, R A

2009-09-01

In Brazil most Construction and Demolition Waste (C&D waste) is not recycled. This situation is expected to change significantly, since new federal regulations oblige municipalities to create and implement sustainable C&D waste management plans which assign an important role to recycling activities. The recycling organizational network and its flows and components are fundamental to C&D waste recycling feasibility. Organizational networks, flows and components involve reverse logistics. The aim of this work is to introduce the concepts of reverse logistics and reverse distribution channel networks and to study the Brazilian C&D waste case.

Directional change during a Miocene R-N geomagnetic polarity reversal recorded by mafic lava flows, Sheep Creek Range, north central Nevada, USA

Science.gov (United States)

Bogue, S. W.; Glen, J. M. G.; Jarboe, N. A.

2017-09-01

Recurring transitional field directions during three Miocene geomagnetic reversals provide evidence that lateral inhomogeneity of the lower mantle affects flow in the outer core. We compare new paleomagnetic results from a composite sequence of 15.2 Ma lava flows in north central Nevada (Sheep Creek Range; 40.7°N, 243.2°E), erupted during a polarity reversal, to published data from Steens Mountain (250 km to the northwest in Oregon) and the Newberry Mountains (650 km to the south in California) that document reversals occurring millions of years and many polarity switches earlier. Alternating field demagnetization, followed by thermal demagnetization in half the samples, clearly isolated the primary thermoremanent magnetization of Sheep Creek Range flows. We correlated results from our three sampled sections to produce a composite record that begins with a single virtual geomagnetic pole (VGP) at low latitude in the Atlantic, followed by two VGPs situated near latitude 30°N in NE Africa. After jumping to 83°N (one VGP), the pole moves to equatorial South America (one VGP), back to NE Africa (three VGPs), to high southern latitudes (two VGPs), back to equatorial South America (three VGPs), and finally to high northern latitudes (nine VGPs). The repeated visits of the transitional VGP to positions in South America and near NE Africa, as well as the similar behavior recorded at Steens Mountain and the Newberry Mountains, suggest that lower mantle or core-mantle boundary features localize core flow structures, thereby imparting a discernible regional structure on the transitional geomagnetic field that persists for millions of years.

Sand transportation and reverse patterns over leeward face of sand dune

Science.gov (United States)

Jiang, Hong; Dun, Hongchao; Tong, Ding; Huang, Ning

2017-04-01

Sand saltation has complex interactions with turbulent flow and dune form. Most models of wind-blown sand consider ideal circumstances such as steady wind velocity and a flat surface, and the bulk of data on wind flow and sand transport over an individual dune has focused mostly on the influence of dune shape or inter-dune space on the wind flow, neglecting the effect of morphology on sand saltation, particularly airflow and sand transportation over the leeward slope. Wind flow structures over the leeward slope of sand dunes have a fundamental influence on the organization of sand dunes. In order to understand sand dune dynamics, lee face airflow and sediment transportation should be paid more attention. Previous field observations could not measure turbulent flow structure well because of the limited observation points and the influence of experiment structure on wind field. In addition, the reverse sand particles over leeward face could not be collected by sand trap in field. Numerous field observations could not measure turbulent flow structure because of the limited observation points and the influence of experimental structures on the wind field. In addition, the reverse transport of sand particles over leeward face could not be collected by sand traps in field. Therefore, this paper aims to investigate the turbulent flow structure and sand transport pattern over the leeward slope. A numerical model of sand saltation over slope terrain is constructed, which also considers the coupling effects between air flow and sand particles. The large eddy simulation method is used to model turbulent flow. Sand transport is simulated by tracking the trajectory of each sand particle. The results show that terrain significantly alters the turbulent air flow structure and wind-blown sand movement, especially over the leeward slope. Here, mass flux increases initially and then decreases with height in the reversed flow region in the direction of wind flow, and the mass flux

Reverse engineering of heavy-ion collisions: Unraveling initial conditions from anisotropic flow data

International Nuclear Information System (INIS)

Retinskaya, Ekaterina

2014-01-01

Ultra-Relativistic heavy-ion physics is a promising field of high energy physics connecting two fields: nuclear physics and elementary particle physics. Experimental achievements of the last years have provided an opportunity to study the properties of a new state of matter created in heavy-ion collisions called quark-gluon plasma. The initial state of two colliding nuclei is affected by fluctuations coming from wave- functions of nucleons. These fluctuations lead to the momentum anisotropy of the hadronic matter which is observed by the detectors. The system created in the collision behaves like a fluid, so the initial state is connected to the final state via hydrodynamic evolution. In this thesis we model the evolution with relativistic viscous hydrodynamics. Our results, combined with experimental data, give non trivial constraints on the initial state, thus achieving 'reverse engineering' of the heavy-ion collisions. The observable which characterizes the momentum anisotropy is the anisotropic flow v n . We present the first measurements of the first harmonic of the anisotropic flow called directed flow v 1 in Pb-Pb collisions at the LHC. We then perform the first viscous hydrodynamic modeling of directed flow and show that it is less sensitive to viscosity than higher harmonics. Comparison of these experimental data with the modeling allows to extract the values of the dipole asymmetry of the initial state, which provides constraints on the models of initial states. A prediction for directed flow v 1 in Au-Au collisions is also made for RHIC. We then perform a similar modeling of the second and third harmonics of the anisotropic flow, called respectively elliptic v 2 and triangular v 3 flow. A combined analysis of the elliptic and triangular flow data compared with viscous hydrodynamic calculations allows us to put constraints on initial ellipticity and triangularity of the system. These constraints are then used as a filter for different models of

A categorical foundation for structured reversible flowchart languages: Soundness and adequacy

OpenAIRE

Glück, Robert; Kaarsgaard, Robin

2017-01-01

Structured reversible flowchart languages is a class of imperative reversible programming languages allowing for a simple diagrammatic representation of control flow built from a limited set of control flow structures. This class includes the reversible programming language Janus (without recursion), as well as more recently developed reversible programming languages such as R-CORE and R-WHILE. In the present paper, we develop a categorical foundation for this class of languages based on inve...

Streaming reversal of energetic particles in the magnetotail during a substorm

Science.gov (United States)

Lui, A. T. Y.; Williams, D. J.; Eastman, T. E.; Frank, L. A.; Akasofu, S.-I.

1984-01-01

A case of reversal in the streaming anisotropy of energetic ions and in the plasma flow observed from the IMP 8 spacecraft during a substorm on February 8, 1978 is studied in detail using measurements of energetic particles, plasma, and magnetic field. Four new features emerge when high time resolution data are examined in detail. The times of streaming reversal of energetic particles in different energy ranges do not coincide with the time of plasma flow reversal. Qualitatively different velocity distributions are observed in earthward and tailward plasma flows during the observed flow reversal intervals. Strong tailward streaming of energetic particles can be detected during northward magnetic field environments and, conversely, earthward streaming in southward field environments. During the period of tailward streaming of energetic particles, earthward streaming fluxes are occasionally detected.

Reversible thermo-pneumatic valves on centrifugal microfluidic platforms.

Science.gov (United States)

Aeinehvand, Mohammad Mahdi; Ibrahim, Fatimah; Harun, Sulaiman Wadi; Kazemzadeh, Amin; Rothan, Hussin A; Yusof, Rohana; Madou, Marc

2015-08-21

Centrifugal microfluidic systems utilize a conventional spindle motor to automate parallel biochemical assays on a single microfluidic disk. The integration of complex, sequential microfluidic procedures on these platforms relies on robust valving techniques that allow for the precise control and manipulation of fluid flow. The ability of valves to consistently return to their former conditions after each actuation plays a significant role in the real-time manipulation of fluidic operations. In this paper, we introduce an active valving technique that operates based on the deflection of a latex film with the potential for real-time flow manipulation in a wide range of operational spinning speeds. The reversible thermo-pneumatic valve (RTPV) seals or reopens an inlet when a trapped air volume is heated or cooled, respectively. The RTPV is a gas-impermeable valve composed of an air chamber enclosed by a latex membrane and a specially designed liquid transition chamber that enables the efficient usage of the applied thermal energy. Inputting thermo-pneumatic (TP) energy into the air chamber deflects the membrane into the liquid transition chamber against an inlet, sealing it and thus preventing fluid flow. From this point, a centrifugal pressure higher than the induced TP pressure in the air chamber reopens the fluid pathway. The behaviour of this newly introduced reversible valving system on a microfluidic disk is studied experimentally and theoretically over a range of rotational frequencies from 700 RPM to 2500 RPM. Furthermore, adding a physical component (e.g., a hemispherical rubber element) to induce initial flow resistance shifts the operational range of rotational frequencies of the RTPV to more than 6000 RPM. An analytical solution for the cooling of a heated RTPV on a spinning disk is also presented, which highlights the need for the future development of time-programmable RTPVs. Moreover, the reversibility and gas impermeability of the RTPV in the

Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats.

Science.gov (United States)

Malin, David H; Lee, David R; Goyarzu, Pilar; Chang, Yu-Hsuan; Ennis, Lalanya J; Beckett, Elizabeth; Shukitt-Hale, Barbara; Joseph, James A

2011-03-01

Previously, 4 mo of a blueberry-enriched (BB) antioxidant diet prevented impaired object recognition memory in aging rats. Experiment 1 determined whether 1- and 2-mo BB diets would have a similar effect and whether the benefits would disappear promptly after terminating the diets. Experiment 2 determined whether a 1-mo BB diet could subsequently reverse existing object memory impairment in aging rats. In experiment 1, Fischer-344 rats were maintained on an appropriate control diet or on 1 or 2 mo of the BB diet before testing object memory at 19 mo postnatally. In experiment 2, rats were tested for object recognition memory at 19 mo and again at 20 mo after 1 mo of maintenance on a 2% BB or control diet. In experiment 1, the control group performed no better than chance, whereas the 1- and 2-mo BB diet groups performed similarly and significantly better than controls. The 2-mo BB-diet group, but not the 1-mo group, maintained its performance over a subsequent month on a standard laboratory diet. In experiment 2, the 19-mo-old rats performed near chance. At 20 mo of age, the rats subsequently maintained on the BB diet significantly increased their object memory scores, whereas the control diet group exhibited a non-significant decline. The change in object memory scores differed significantly between the two diet groups. These results suggest that a considerable degree of age-related object memory decline can be prevented and reversed by brief maintenance on BB diets. Copyright © 2011 Elsevier Inc. All rights reserved.

Modulation of hepatic stellate cells and reversibility of hepatic fibrosis

Energy Technology Data Exchange (ETDEWEB)

Huang, Yu, E-mail: 1293363632@QQ.com [Faculty of Graduate Studies of Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region (China); Deng, Xin, E-mail: Hendly@163.com [Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 10 East China Road, Nanning 530011, Guangxi Zhuang Autonomous Region (China); Liang, Jian, E-mail: lj99669@163.com [Guangxi University of Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region (China)

2017-03-15

Hepatic fibrosis (HF) is the pathological component of a variety of chronic liver diseases. Hepatic stellate cells (HSC) are the main collagen-producing cells in the liver and their activation promotes HF. If HSC activation and proliferation can be inhibited, HF occurrence and development can theoretically be reduced and even reversed. Over the past ten years, a number of studies have addressed this process, and here we present a review of HSC modulation and HF reversal. - Highlights: • We present a review of the modulation of hepatic stellate cells (HSC) and reversibility of hepatic fibrosis (HF). • HSC are the foci of HF occurrence and development, HF could be prevented and treated by modulating HSC. • If HSC activation and proliferation can be inhibited, HF could theoretically be inhibited and even reversed. • Prevention or reversal of HSC activation, or promotion of HSC apoptosis, immune elimination, and senescence may prevent, inhibit or reverse HF.

Experimental demonstration of the reverse flow catalytic membrane reactor concept for energy efficient syngas production. Part 1: Influence of operating conditions

NARCIS (Netherlands)

Smit, J.; Bekink, G.J.; Sint Annaland, van M.; Kuipers, J.A.M.

2007-01-01

In this contribution the technical feasibility of the reverse flow catalytic membrane reactor (RFCMR) concept with porous membranes for energy efficient syngas production is investigated. In earlier work an experimental proof of principle was already provided [Smit, J., Bekink, G.J., van Sint

Reversible Lithium Neurotoxicity: Review of the Literature

Science.gov (United States)

Netto, Ivan

2012-01-01

Objective: Lithium neurotoxicity may be reversible or irreversible. Reversible lithium neurotoxicity has been defined as cases of lithium neurotoxicity in which patients recovered without any permanent neurologic sequelae, even after 2 months of an episode of lithium toxicity. Cases of reversible lithium neurotoxicity differ in clinical presentation from those of irreversible lithium neurotoxicity and have important implications in clinical practice. This review aims to study the clinical presentation of cases of reversible lithium neurotoxicity. Data Sources: A comprehensive electronic search was conducted in the following databases: MEDLINE (PubMed), 1950 to November 2010; PsycINFO, 1967 to November 2010; and SCOPUS (EMBASE), 1950 to November 2010. MEDLINE and PsycINFO were searched by using the OvidSP interface. Study Selection: A combination of the following search terms was used: lithium AND adverse effects AND central nervous system OR neurologic manifestation. Publications cited include articles concerned with reversible lithium neurotoxicity. Data Extraction: The age, sex, clinical features, diagnostic categories, lithium doses, serum lithium levels, precipitating factors, and preventive measures of 52 cases of reversible lithium neurotoxicity were extracted. Data Synthesis: Among the 52 cases of reversible lithium neurotoxicity, patients ranged in age from 10 to 80 years and a greater number were female (P = .008). Most patients had affective disorders, schizoaffective disorders, and/or depression (P lithium levels were less than or equal to 1.5 mEq/L (P lithium, underlying brain pathology, abnormal tissue levels, specific diagnostic categories, and elderly populations were some of the precipitating factors reported for reversible lithium neurotoxicity. The preventive measures were also described. Conclusions: Reversible lithium neurotoxicity presents with a certain clinical profile and precipitating factors for which there are appropriate

Reversible lithium neurotoxicity: review of the literatur.

Science.gov (United States)

Netto, Ivan; Phutane, Vivek H

2012-01-01

Lithium neurotoxicity may be reversible or irreversible. Reversible lithium neurotoxicity has been defined as cases of lithium neurotoxicity in which patients recovered without any permanent neurologic sequelae, even after 2 months of an episode of lithium toxicity. Cases of reversible lithium neurotoxicity differ in clinical presentation from those of irreversible lithium neurotoxicity and have important implications in clinical practice. This review aims to study the clinical presentation of cases of reversible lithium neurotoxicity. A comprehensive electronic search was conducted in the following databases: MEDLINE (PubMed), 1950 to November 2010; PsycINFO, 1967 to November 2010; and SCOPUS (EMBASE), 1950 to November 2010. MEDLINE and PsycINFO were searched by using the OvidSP interface. A combination of the following search terms was used: lithium AND adverse effects AND central nervous system OR neurologic manifestation. Publications cited include articles concerned with reversible lithium neurotoxicity. The age, sex, clinical features, diagnostic categories, lithium doses, serum lithium levels, precipitating factors, and preventive measures of 52 cases of reversible lithium neurotoxicity were extracted. Among the 52 cases of reversible lithium neurotoxicity, patients ranged in age from 10 to 80 years and a greater number were female (P = .008). Most patients had affective disorders, schizoaffective disorders, and/or depression (P lithium levels were less than or equal to 1.5 mEq/L (P lithium, underlying brain pathology, abnormal tissue levels, specific diagnostic categories, and elderly populations were some of the precipitating factors reported for reversible lithium neurotoxicity. The preventive measures were also described. Reversible lithium neurotoxicity presents with a certain clinical profile and precipitating factors for which there are appropriate preventive measures. This recognition will help in early diagnosis and prompt treatment of

SELECTED PROBLEMS OF REVERSE LOGISTICS IN POLAND

OpenAIRE

Agata Mesjasz-Lech

2009-01-01

This paper presents the essence of reverse logistics and directions of physical and information flows between logistic network partners. It also analyses effects of implementation of the principles of reverse logistics in Poland in the years 2004-2007

Gliding arc in tornado using a reverse vortex flow

International Nuclear Information System (INIS)

Kalra, Chiranjeev S.; Cho, Young I.; Gutsol, Alexander; Fridman, Alexander; Rufael, Tecle S.

2005-01-01

The present article reports a new gliding arc (GA) system using a reverse vortex flow ('tornado') in a cylindrical reactor (gliding arc in tornado, or GAT), as used to preserve the main advantages of traditional GA systems and overcome their main drawbacks. The primary advantages of traditional GA systems retained in the present GAT are the possibility to generate transitional plasma and to avoid considerable electrode erosion. In contrast to a traditional GA, the new GAT system ensures much more uniform gas treatment and has a significantly larger gas residence time in the reactor. The present article also describes the design of the new reactor and its stable operation regime when the variation of GAT current is very small. These features are understood to be very important for most viable applications. Additionally the GAT provides near-perfect thermal insulation from the reactor wall, indicating that the present GAT does not require the reactor wall to be constructed of high-temperature materials. The new GAT system, with its unique properties such as a high level of nonequilibrium and a large residence time, looks very promising for many industrial applications including fuel conversion, carbon dioxide conversion to carbon monoxide and oxygen, surface treatment, waste treatment, flame stabilization, hydrogen sulfide treatment, etc

Preventive Security-Constrained Optimal Power Flow Considering UPFC Control Modes

Directory of Open Access Journals (Sweden)

Xi Wu

2017-08-01

Full Text Available The successful application of the unified power flow controller (UPFC provides a new control method for the secure and economic operation of power system. In order to make the full use of UPFC and improve the economic efficiency and static security of a power system, a preventive security-constrained power flow optimization method considering UPFC control modes is proposed in this paper. Firstly, an iterative method considering UPFC control modes is deduced for power flow calculation. Taking into account the influence of different UPFC control modes on the distribution of power flow after N-1 contingency, the optimization model is then constructed by setting a minimal system operation cost and a maximum static security margin as the objective. Based on this model, the particle swarm optimization (PSO algorithm is utilized to optimize power system operating parameters and UPFC control modes simultaneously. Finally, a standard IEEE 30-bus system is utilized to demonstrate that the proposed method fully exploits the potential of static control of UPFC and significantly increases the economic efficiency and static security of the power system.

Recleaning of HEPA filters by reverse flow - evaluation of the underlying processes and the cleaning technique

International Nuclear Information System (INIS)

Leibold, H.; Leiber, T.; Doeffert, I.; Wilhelm, J.G.

1993-08-01

HEPA filter operation at high concentrations of fine dusts requires the periodic recleaning of the filter units in their service locations. Due to the low mechanical stress induced during the recleaning process the regenration via low pressure reverse flow is a very suitable technique. Recleanability of HEPA filter had been attained for particle diameter >0,4 μm at air velocities up to 1 m/s, but filter clogging occurred in case of smaller particles. The recleaning forces are too weak for particles [de

Pioneer 7 observations of plasma flow and field reversal regions in the distant geomagnetic tail

International Nuclear Information System (INIS)

Walker, R.C.; Villante, U.; Lazarus, A.J.

1975-01-01

We present the results of an extensive analysis of plasma and magnetic field data from Pioneer 7 taken in the geomagnetic tail approximately 1000 R/sub E/ downstream from earth. The principal observations are (1) measurable fluxes of protons in the tail, flowing away from earth, sometimes with a double-peaked velocity distribution; (2) field reversal regions in which the field changes from radial to antiradial by a vector rotation in the north-south plane; and (3) general characteristics of the tail similar to those observed near earth with good correlation between taillike magnetic fields and plasma

Pioneer 7 observations of plasma flow and field reversal regions in the distant geomagnetic tail

Science.gov (United States)

Walker, R. C.; Lazarus, A. J.; Villante, U.

1975-01-01

The present paper gives the results of an extensive analysis of plasma and magnetic-field data from Pioneer 7 taken in the geomagnetic tail approximately 1000 earth radii downstream from earth. The principal observations are: (1) measurable fluxes of protons in the tail, flowing away from earth, sometimes with a double-peaked velocity distribution; (2) field reversal regions in which the field changes from radial to antiradial by a vector rotation in the north-south plane; and (3) general characteristics of the tail similar to those observed near earth with good correlation between taillike magnetic fields and plasma.

CO2 Dissociation by Low Current Gliding Discharge in the Reverse Vortex Flow

Science.gov (United States)

Gutsol, Alexander

2012-10-01

If performed with high energy efficiency, plasma-chemical dissociation of carbon dioxide can be a way of converting and storing energy when there is an excess of electric energy, for example generated by solar elements of wind turbines. CO2 dissociation with efficiency of up to 90% was reported earlier for low pressure microwave discharge in supersonic flow. A new plasma-chemical system uses a low current gliding discharge in the reverse vortex flow of plasma gas. The system is a development of the Gliding Arc in Tornado reactor. The system was used to study dissociation of CO2 in wide ranges of the following experimental parameters: reactor pressure (15-150 kPa), discharge current (50-500 mA), gas flow rate (3-30 liters per minute), and electrode gap length (1-10 cm). Additionally, the effect of thermal energy recuperation on CO2 dissociation efficiency was tested. Plasma chemical efficiency of CO2 dissociation is very low (about 3%) in a short discharge at low pressures (about 15 kPa) when it is defined by electronic excitation. The highest efficiency (above 40%) was reached at pressures 50-70 kPa in a long discharge with thermal energy recuperation. It means that the process is controlled by thermal dissociation with subsequent effective quenching. Plasma chemical efficiency was determined from the data of chromatographic analysis and oscilloscope electric power integration, and also was checked calorimetrically by the thermal balance of the system.

Reversal of subtidal dune asymmetries caused by seasonally reversing wind-driven currents in Torres Strait, northeastern Australia

Science.gov (United States)

Harris, Peter T.

1991-07-01

Large subtidal sand dunes (sandwaves) located in Adolphus Channel, Torres Strait, have been observed to reverse their asymmetric orientation between September-February. This has been attributed to a reversal in wind-driven currents, which flow westward during the SE trade season (April-November) and eastwards during the NW monsoon season [December-March: HARRIS (1989) Continental Shelf Research, 9, 981-1002]. Observations in September 1988 and February 1989 from another area of dunes in Torres Strait corroborate this asymmetry reversal pattern. The results indicate that such reversals may be common in Torres Strait and in other areas where subtidal bedforms are subject to modification by superimposed, seasonally reversing, wind-driven currents.

Occurrence and prevention of enhanced oxide deposition in boiler flow control orifices

International Nuclear Information System (INIS)

Woolsey, I.S.; Thomas, D.M.; Garbett, K.; Bignold, G.J.

1989-10-01

Once-through boilers, such as those of the AGRs, incorporate flow control orifices at the boiler inlet to ensure a satisfactory flow distribution and stability in the parallel flow paths of the boiler. Deposition of corrosion products in the flow control orifice leads to changes in the orifice pressure loss characteristics, which could lead to problems of flow maldistribution within the boiler, and any adverse consequences resulting from this, such as tube overheating. To date, AGR boiler inlet orifices have not suffered significant fouling due to corrosion products in the boiler feedwater. However, oxide deposition in orifices has been observed in other plants, and in experimental loops operating under conditions very similar to those at inlet to AGR boilers. The lack of deposition in AGR flow control orifices is therefore somewhat surprising. This Report describes studies carried out to examine the factors controlling oxide deposition in flow control orifices, the intention of the work being to explain why deposition has not occurred in AGR boilers to date, and to provide means of preventing deposition in the future should this prove necessary. (author)

Fundamentals of reversible flowchart languages

DEFF Research Database (Denmark)

Yokoyama, Tetsuo; Axelsen, Holger Bock; Glück, Robert

2016-01-01

Abstract This paper presents the fundamentals of reversible flowcharts. They are intended to naturally represent the structure and control flow of reversible (imperative) programming languages in a simple computation model, in the same way classical flowcharts do for conventional languages......, structured reversible flowcharts are as expressive as unstructured ones, as shown by a reversible version of the classic Structured Program Theorem. We illustrate how reversible flowcharts can be concretized with two example programming languages, complete with syntax and semantics: a low-level unstructured...... language and a high-level structured language. We introduce concrete tools such as program inverters and translators for both languages, which follow the structure suggested by the flowchart model. To further illustrate the different concepts and tools brought together in this paper, we present two major...

Start-up assist by magnetized plasma flow injection in TPE-RX reversed-field pinch

Energy Technology Data Exchange (ETDEWEB)

Asai, T. [College of Science and Technology, Nihon University, 1-8 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308 (Japan)]. E-mail: asai@phys.cst.nihon-u.ac.jp; Nagata, M. [Graduate School of Engineering, University of Hyogo, Himeji (Japan); Koguchi, H. [National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba (Japan); Hirano, Y. [National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba (Japan); Sakakita, H. [National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba (Japan); Yambe, K. [National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba (Japan); Kiyama, S. [National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba (Japan)

2006-11-15

A reversed-field pinch (RFP) start-up assisted by a magnetized plasma flow injection was demonstrated for the first time on a TPE-RX machine. This sequence of experiments aimed to establish a new method of ionization, gas-fill and helicity injection in the start-up phase of an RFP. In this start-up method, magnetized and well-ionized plasma is formed by a magnetized coaxial plasma gun and injected into the torus chamber as an initial pre-ionized plasma for RFP formation. In the initial experiments, attenuated density pump-out and comparatively slow decay of the toroidal flux and plasma current were observed as evidence of its being an effective start-up method.

CONCEPTUAL ISSUES REGARDING REVERSE LOGISTICS

Directory of Open Access Journals (Sweden)

Ioana Olariu

2013-12-01

Full Text Available As the power of consumers is growing, the product return for customer service and customer retention has become a common practice in the competitive market, which propels the recent practice of reverse logistics in companies. Many firms attracted by the value available in the flow, have proactively participated in handling returned products at the end of their usefulness or from other parts of the product life cycle. Reverse logistics is the flow and management of products, packaging, components and information from the point of consumption to the point of origin. It is a collection of practices similar to those of supply chain management, but in the opposite direction, from downstream to upstream. It involves activities such as reuse, repair, remanufacture, refurbish, reclaim and recycle. For the conventional forward logistics systems, the flow starts upstream as raw materials, later as manufactured parts and components to be assembled and continues downstream to reach customers as final products to be disposed once they reach their economic or useful lives. In reverse logistics, the disposed products are pushed upstream to be repaired, remanufactured, refurbished, and disassembled into components to be reused or as raw material to be recycled for later use.

Prevention of disease progression by cardiac resynchronization therapy in patients with asymptomatic or mildly symptomatic left ventricular dysfunction: insights from the European cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial

DEFF Research Database (Denmark)

Daubert, Claude; Gold, Michael R; Abraham, William T

2009-01-01

were decreased in this patient population in New York Heart Association functional classes I or II. These observations suggest that CRT prevents the progression of disease in patients with asymptomatic or mildly symptomatic LV dysfunction. (REsynchronization reVErses Remodeling in Systolic Left v......OBJECTIVES: The aim of this study was to determine the long-term effects of cardiac resynchronization therapy (CRT) in the European cohort of patients enrolled in the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial. BACKGROUND: Previous data suggest...... that CRT slows disease progression and improves the outcomes of asymptomatic or mildly symptomatic patients with left ventricular (LV) dysfunction and a wide QRS complex. METHODS: We randomly assigned 262 recipients of CRT pacemakers or defibrillators, with QRS > or =120 ms and LV ejection fraction...

Reverse Flow Routing in a Bayesian Framework Using a GPU-accelerated 2D Shallow Water Model

Science.gov (United States)

D'Oria, M.; Ferrari, A.; Mignosa, P.; Tanda, M. G.; Vacondio, R.

2017-12-01

Knowledge of discharge hydrographs in specific sites of natural rivers is important for water resource management, flood frequency analysis, design of structures, etc. Many times, the flood hydrograph is needed in a river section upstream of a monitoring station; here the flood wave differs from the upstream one because of the effects of resistance, channel storage, lateral inflow, etc. Reverse flow routing is a method that allows obtaining hydrographs in upstream ungauged stations using information available at downstream monitored sites. In this study, we propose an inverse procedure, based on a Bayesian Geostatistical Approach, to solve the reverse problem. The upstream flow values over time (parameters) are considered as random variables and a-priori information about the parameters and observations (downstream discharge or water level values) are combined together in a Bayesian framework. The methodology needs a forward model of the considered open channel that includes the upstream ungauged station and the downstream gauged one and it is able to describe, with sufficient accuracy, the hydraulic routing processes. In many real cases, especially when large floodable areas are involved, a 1D hydraulic model is not able to capture the complex river hydrodynamic and a 2D model must be used. The inverse procedure requires a high number of flow model run to linearize the forward problem through multiple evaluations of a Jacobian matrix (sensitivity of each observation to each parameter) using a finite difference approach. For this reason, the computational efficiency of the forward model is a crucial element to reduce the overall computational costs. Therefore, in this work we used, in combination with the inverse procedure, a GPU-parallel numerical model for the solution of the 2D Shallow Water equations (implemented in CUDA/C++ code) that allows achieving ratio of physical to computational time of about 500-1000 (depending on the test case features). In addition

Buoyancy-driven flow excursions in fuel assemblies

International Nuclear Information System (INIS)

Laurinat, J.E.; Paul, P.K.; Menna, J.D.

1995-01-01

A power limit criterion was developed for a postulated Loss of Pumping Accident (LOPA) in one of the recently shut down heavy water production reactors at the Savannah River Site. These reactors were cooled by recirculating heavy water moderator downward through channels in cylindrical fuel tubes. Powers were limited to safeguard against a flow excursion in one of more of these parallel channels. During-full-power operation, limits safeguarded against a boiling flow excursion. At low flow rates, during the addition of emergency cooling water, buoyant forces reverse the flow in one of the coolant channels before boiling occurs. As power increased beyond the point of flow reversal, the maximum wall temperature approaches the fluid saturation temperature, and a thermal excursion occurs. The power limit criterion for low flow rates was the onset of flow reversal. To determine conditions for flow reversal, tests were performed in a mock-up of a fuel assembly that contained two electrically heated concentric tubes surrounded by three flow channels. These tests were modeled using a finite difference thermal-hydraulic code. According to code calculations, flow reversed in the outer flow channel before the maximum wall temperature reached the local fluid saturation temperature. Thermal excursions occurred when the maximum wall temperature approximately equaled the saturation temperature. For a postulated LOPA, the flow reversal criterion for emergency cooling water addition was more limiting than the boiling excursion criterion for full power operation. This criterion limited powers to 37% of the limiting power for previous long-term reactor operations

Buoyancy-driven flow excursions in fuel assemblies

Energy Technology Data Exchange (ETDEWEB)

Laurinat, J.E.; Paul, P.K.; Menna, J.D. [Westinghouse Savannah River Company, Aiken, SC (United States)

1995-09-01

A power limit criterion was developed for a postulated Loss of Pumping Accident (LOPA) in one of the recently shut down heavy water production reactors at the Savannah River Site. These reactors were cooled by recirculating heavy water moderator downward through channels in cylindrical fuel tubes. Powers were limited to safeguard against a flow excursion in one of more of these parallel channels. During-full-power operation, limits safeguarded against a boiling flow excursion. At low flow rates, during the addition of emergency cooling water, buoyant forces reverse the flow in one of the coolant channels before boiling occurs. As power increased beyond the point of flow reversal, the maximum wall temperature approaches the fluid saturation temperature, and a thermal excursion occurs. The power limit criterion for low flow rates was the onset of flow reversal. To determine conditions for flow reversal, tests were performed in a mock-up of a fuel assembly that contained two electrically heated concentric tubes surrounded by three flow channels. These tests were modeled using a finite difference thermal-hydraulic code. According to code calculations, flow reversed in the outer flow channel before the maximum wall temperature reached the local fluid saturation temperature. Thermal excursions occurred when the maximum wall temperature approximately equaled the saturation temperature. For a postulated LOPA, the flow reversal criterion for emergency cooling water addition was more limiting than the boiling excursion criterion for full power operation. This criterion limited powers to 37% of the limiting power for previous long-term reactor operations.

The topology of intrasector reversals of the interplanetary magnetic field

Science.gov (United States)

Kahler, S. W.; Crooker, N. U.; Gosling, J. T.

1996-11-01

A technique has been developed recently to determine the polarities of interplanetary magnetic fields relative to their origins at the Sun by comparing energetic electron flow directions with local magnetic field directions. Here we use heat flux electrons from the Los Alamos National Laboratory (LANL) plasma detector on the ISEE 3 spacecraft to determine the field polarities. We examine periods within well-defined magnetic sectors when the field directions appear to be reversed from the normal spiral direction of the sector. About half of these intrasector field reversals (IFRs) are cases in which the polarities match those of the surrounding sectors, indicating that those fields have been folded back toward the Sun. The more interesting cases are those with polarity reversals. We find no clear cases of isolated reverse polarity fields, which suggests that islands of reverse polarity in the solar source dipole field probably do not exist. The IFRs with polarity reversals are strongly associated with periods of bidirectional electron flows, suggesting that those fields occur only in conjunction with closed fields. We propose that both those IFRs and the bidirectional flows are signatures of coronal mass ejections (CMEs). In that case, many interplanetary CMEs are larger and more complex than previously thought, consisting of both open and closed field components.

Exposure with response prevention versus habit reversal in Tourettes's syndrome: a controlled study.

Science.gov (United States)

Verdellen, Cara W J; Keijsers, Ger P J; Cath, Danielle C; Hoogduin, Cees A L

2004-05-01

The intentional nature of tics provides the opportunity to apply behavioural interventions aimed at tic reduction through interruption of stimulus-response sequences. The aim of this study has been to evaluate the effect of exposure and response prevention (ER) versus habit reversal (HR) in 43 Tourette's syndrome (TS) patients. The three outcome measures were: the Yale Global Tic Severity Scale (YGTSS), 15-min tic frequency registrations monitored at the institute and 15-min home tic frequency registrations. Both treatment conditions resulted in statistically significant improvements on all outcome measures (p < 0.001). No significant differences were found between the treatment conditions on any of the outcome measures, although there was a tendency in favour of ER on the YGTSS (p = 0.05). These results suggest that, at least in the short term, TS tic symptoms can be treated effectively with both types of treatment.

Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT Polymerization Using Continuous Flow Processing

Directory of Open Access Journals (Sweden)

Nenad Micic

2014-01-01

Full Text Available A controlled radical polymerization process using the Reversible Addition-Fragmentation Chain Transfer (RAFT approach was scaled up by a factor of 100 from a small laboratory scale of 5 mL to a preparative scale of 500 mL, using batch and continuous flow processing. The batch polymerizations were carried out in a series of different glass vessels, using either magnetic or overhead stirring, and different modes of heating: Microwave irradiation or conductive heating in an oil bath. The continuous process was conducted in a prototype tubular flow reactor, consisting of 6 mm ID stainless steel tubing, fitted with static mixers. Both reactor types were tested for polymerizations of the acid functional monomers acrylic acid and 2-acrylamido-2-methylpropane-1-sulfonic acid in water at 80 °C with reaction times of 30 to 40 min. By monitoring the temperature during the exothermic polymerization process, it was observed that the type and size of reactor had a significant influence on the temperature profile of the reaction.

Initial ideas for automatic design and verification of control logic in reversible HDLs

DEFF Research Database (Denmark)

Wille, Robert; Keszocze, Oliver; Othmer, Lars

2016-01-01

not obvious. Moreover, implementations exist which may not be realized with a reversible control flow at all. In this work, we propose automatic methods for descriptions in the reversible HDL SyReC that can generate the required fi-conditions and check whether a reversible control flow indeed can be realized....... The envisioned solution utilizes predicate transformer semantics based on Hoare logic. The presented ideas constitute the first steps towards automatic methods for these important designs steps in the domain of reversible circuit design....

Solutal Marangoni flow as the cause of ring stains from drying salty colloidal drops

Science.gov (United States)

Marin, Alvaro; Karpitschka, Stefan; Rossi, Massimiliano; Kaehler, Christian J.; Noguera-Marin, Diego; Rodriguez-Valverde, Miguel A.

2017-11-01

Salts can be found in different forms in almost any evaporating droplet in nature, our homes and in laboratories. The transport processes in such apparently simple systems differ strongly from `sweet' evaporating droplets since the liquid flows in the inverse direction due to Marangoni stresses at the surface. Such an effect has crucial consequences to salt crystallization processes and to the evaporation itself. In this work we show measurements that not only confirm clearly the details of the inverted flow patterns, but also permit us to calculate the surface tension gradients responsible for the reversal. Such a reversal does not prevent the coffee-stain effect; on the contrary, particles accumulate and get trapped at the liquid-air interface driven by the surface flow. In order to prove this, we show measurements of the full three-dimensional flow inside the evaporating salty droplet, confocal imaging is used to quantify the growth of the particle deposits for different salt concentrations, and we compare the experimental results with numerical simulations that capture the solvent evaporation, the evaporation-induced liquid flow and the quasi-equilibrium liquid-gas interface.

Centrifugal compressor tip clearance and impeller flow

Energy Technology Data Exchange (ETDEWEB)

Jaatinen-Varri, Ahti; Tiainen, Jonna; Turunen-Saaresti, Teemu; Gronman, Aki; Ameli, Alireza; Backman, Jari [Laboratory of Fluid Dynamics, LUT School of Energy Systems, Lappeenranta University of Technology, Lappeenranta (Finland); Engeda, Abraham [Turbomachinery Laboratory, Dept. of Mechanical Engineering, Michigan State University, East Lansing (United States)

2016-11-15

Compressors consume a considerable portion of the electricity used in the industrial sector. Hence, improvements in compressor efficiency lead to energy savings and reduce environmental impacts. The efficiency of an unshrouded centrifugal compressor suffers from leakage flow over the blade tips. The effect of tip leakage flow on the passage flow differs between the full and splitter blade passages. In this study, the differences in the flow fields between the full and splitter blade passages were studied numerically in detail. An industrial high-speed compressor with a design pressure ratio of 1.78 was modelled. Numerical studies were conducted with six different tip clearances and three different diffuser widths. The results show that increasing tip clearance considerably increases the reversed flow into the impeller with an unpinched diffuser. The reversed flow then partly mixes into the flow in the same blade passage it entered the impeller and the rest migrates over the blade, mixing with the tip clearance flow. Furthermore, as the reversed and clearance flow mix into the wake, the wake is weakened. As pinch reduces both the reversed flow and clearance flow, the passage wakes are stronger with pinches. However, the pinch is beneficial as the losses at the impeller outlet decrease.

Centrifugal compressor tip clearance and impeller flow

International Nuclear Information System (INIS)

Jaatinen-Varri, Ahti; Tiainen, Jonna; Turunen-Saaresti, Teemu; Gronman, Aki; Ameli, Alireza; Backman, Jari; Engeda, Abraham

2016-01-01

Compressors consume a considerable portion of the electricity used in the industrial sector. Hence, improvements in compressor efficiency lead to energy savings and reduce environmental impacts. The efficiency of an unshrouded centrifugal compressor suffers from leakage flow over the blade tips. The effect of tip leakage flow on the passage flow differs between the full and splitter blade passages. In this study, the differences in the flow fields between the full and splitter blade passages were studied numerically in detail. An industrial high-speed compressor with a design pressure ratio of 1.78 was modelled. Numerical studies were conducted with six different tip clearances and three different diffuser widths. The results show that increasing tip clearance considerably increases the reversed flow into the impeller with an unpinched diffuser. The reversed flow then partly mixes into the flow in the same blade passage it entered the impeller and the rest migrates over the blade, mixing with the tip clearance flow. Furthermore, as the reversed and clearance flow mix into the wake, the wake is weakened. As pinch reduces both the reversed flow and clearance flow, the passage wakes are stronger with pinches. However, the pinch is beneficial as the losses at the impeller outlet decrease

Reverse innovation in maternal health.

Science.gov (United States)

Firoz, Tabassum; Makanga, Prestige Tatenda; Nathan, Hannah L; Payne, Beth; Magee, Laura A

2017-09-01

Reverse innovation, defined as the flow of ideas from low- to high-income settings, is gaining traction in healthcare. With an increasing focus on value, investing in low-cost but effective and innovative solutions can be of mutual benefit to both high- and low-income countries. Reverse innovation has a role in addressing maternal health challenges in high-income countries by harnessing these innovative solutions for vulnerable populations especially in rural and remote regions. In this paper, we present three examples of 'reverse innovation' for maternal health: a low-cost, easy-to-use blood pressure device (CRADLE), a diagnostic algorithm (mini PIERS) and accompanying mobile app (PIERS on the Move), and a novel method for mapping maternal outcomes (MOM).

The Reverse Supply Chain: Configuration, Integration and Profitability

DEFF Research Database (Denmark)

Gobbi, Chiara

2008-01-01

This thesis presents the results of a qualitative investigation that has been conducted in order to enhance knowledge of the reverse supply chain management field. Two aspects of the reverse flow need to be taken into consideration: the importance of introducing mechanisms that promote the circui......This thesis presents the results of a qualitative investigation that has been conducted in order to enhance knowledge of the reverse supply chain management field. Two aspects of the reverse flow need to be taken into consideration: the importance of introducing mechanisms that promote...... the circuitry of resources in order to protect the environment, and the increasing awareness that if strategically managed, the reverse chain represents an opportunity for profit generation and for improving the competitive position of a firm. In the first case, the main stakeholders are represented...... within the 27 Member States, reaching approximately 14-24 Kg. per inhabitant in Western Europe and the 6-12 Kg. per inhabitant in the New Member States. In the second case, the main stakeholder is the firm, the producer that has the possibility of exploring new opportunities to achieve a competitive...

Postoperative Reverse Remodeling and Symptomatic Improvement in Normal-Flow Low-Gradient Aortic Stenosis After Aortic Valve Replacement.

Science.gov (United States)

Carter-Storch, Rasmus; Møller, Jacob E; Christensen, Nicolaj L; Irmukhadenov, Akhmadjon; Rasmussen, Lars M; Pecini, Redi; Øvrehus, Kristian A; Søndergård, Eva V; Marcussen, Niels; Dahl, Jordi S

2017-12-01

Severe aortic stenosis (AS) most often presents with reduced aortic valve area (gradient (≥40 mm Hg; normal-flow high-gradient AS) or low mean gradient (normal-flow low-gradient [NFLG] AS). The benefit of aortic valve replacement (AVR) among NFLG patients is controversial. We compared the impact of NFLG condition on preoperative left ventricular (LV) remodeling and myocardial fibrosis and postoperative remodeling and symptomatic benefit. Eighty-seven consecutive patients with reduced aortic valve area and normal stroke volume index undergoing AVR underwent echocardiography, magnetic resonance imaging, a 6-minute walk test, and measurement of natriuretic peptides before and 1 year after AVR. Myocardial fibrosis was assessed from magnetic resonance imaging. Patients were stratified as NFLG or normal-flow high-gradient. In total, 33 patients (38%) had NFLG. Before AVR, they were characterized by similar symptom burden but less severe AS measured by aortic valve area index (0.50±0.09 versus 0.40±0.08 cm 2 /m 2 ; P gradient condition independently predicted change in LV mass index. Patients with NFLG had less severe AS and LV remodeling than patients with normal-flow high-gradient. Furthermore, NFLG patients experienced less reverse remodeling but the same symptomatic benefit. URL: http://www.clinicaltrials.gov. Unique identifier: NCT02316587. © 2017 American Heart Association, Inc.

Reversal of target-specific oral anticoagulants

Science.gov (United States)

Siegal, D.M.; Cuker, Adam

2014-01-01

Target-specific oral anticoagulants (TSOACs) provide safe and effective anticoagulation for the prevention and treatment of thrombosis in a variety of clinical settings by interfering with the activity of thrombin (dabigatran) or factor Xa (rivaroxaban, apixaban, edoxaban, betrixaban). Although TSOACs have practical advantages over vitamin K antagonists (VKAs), there are currently no antidotes to reverse their anticoagulant effect. Herein we summarize the available evidence for TSOAC reversal using nonspecific and specific reversal agents. We discuss important limitations of existing evidence, which is derived from studies in human volunteers, animal models and in vitro experiments. Studies evaluating the safety and efficacy of reversal agents on clinical outcomes such as bleeding and mortality in patients with TSOAC-associated bleeding are needed. PMID:24880102

Neutral Red and Ferroin as Reversible and Rapid Redox Materials for Redox Flow Batteries.

Science.gov (United States)

Hong, Jeehoon; Kim, Ketack

2018-04-17

Neutral red and ferroin are used as redox indicators (RINs) in potentiometric titrations. The rapid response and reversibility that are prerequisites for RINs are also desirable properties for the active materials in redox flow batteries (RFBs). This study describes the electrochemical properties of ferroin and neutral red as a redox pair. The rapid reaction rates of the RINs allow a cell to run at a rate of 4 C with 89 % capacity retention after the 100 th  cycle. The diffusion coefficients, electrode reaction rates, and solubilities of the RINs were determined. The electron-transfer rate constants of ferroin and neutral red are 0.11 and 0.027 cm s -1 , respectively, which are greater than those of the components of all-vanadium and Zn/Br 2 cells. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Synergistic effects of the safety factor and shear flows on development of internal transport barriers in reversed shear plasmas

International Nuclear Information System (INIS)

Wang, A.K.; Dong, J.Q.; Qu, W.X.; Qiu, X.M.

2002-01-01

A new suppression mechanism of turbulent transport, characteristic of the synergism between safety factor and shear flows, is proposed to explain the internal transport barriers (ITBs) observed in neutral-beam-heated tokamak discharges with reversed magnetic shear. It is shown that the evolution of turbulent transport with the strength of the suppression mechanism reproduces the basic features of the formation and development of ITBs observed in experiments. In addition, the present analyses predict the possibility of global ion and electron heat transport barriers

Streaming reversal of energetic particles in the magnetetail during a substorm

International Nuclear Information System (INIS)

Lui, A.T.Y.; Williams, D.J.; Eastman, T.E.; Frank, L.A.; Akasofu, S.

1984-01-01

Reversal from tailward streaming to earthward streaming of energetic ions at 0.29--0.50 MeV during a substorm on February 3, 1978, is studied with measurements of energetic particles, plasma, and magnetic field from that IMP 8 spacecraft near the dusk flank of the magnetotail. Four new features emerge when high time resolution data are examined in detail. The times of reversal from tailward to earthward streaming of energetic ions and from tailward to earthward plasma flow do not coincide. Second, the velocity distribution in the tailward flowing plasma has a cresent shape, whereas the velocity distribution in the earthward flowing plasma has a crescent shape, whereas the velocity distribution in the earthward flowing plasma resembles a convecting Maxwellian. Third, tailward streaming of energetic ions is sometime detected in northward magnetic field regions and conversely, earthward streaming in southward field environments. Fourth, energetic ions scattering earthward are occasionally present in conjunction with a strong tailward streaming population in the same energy range. These new features suggest that the streaming reversal of energetic ions and the plasma flow reversal in this event are due to the spacecraft traversing different plasma regions during the substorm-associated configurational change of the plasma sheet and the magnetotail and is unrelated to the motion of an acceleration region such as an X type neutral line moving past the spacecraft

Maximizing Home Equity or Preventing Home Loss: Reverse Mortgage Decision Making and Racial Inequality.

Science.gov (United States)

Keene, Danya E; Sarnak, Ann; Coyle, Caitlin

2018-03-07

Reverse mortgages are loans that allow older homeowners to borrow from their home equity with no repayment due until the borrower dies or moves out of the home. We currently know very little about how homeowners evaluate and experience reverse mortgages as solutions to their financial and housing needs in later life. Furthermore, despite an increasingly diverse population of reverse mortgage borrowers, we know little about how social inequalities may contribute to reverse mortgage decisions and their outcomes. In this paper, we examine reverse mortgage decision-making and experiences in a racially and economically diverse sample of older US homeowners. We conducted 44 in-depth interviews with older homeowners who were considering or who had obtained a reverse mortgage loan. We inductively and iteratively developed a thematic coding scheme that was applied to all interview transcripts. Our analysis produced a dichotomous schema of reverse mortgage decision making that was shaped by social and economic opportunities and constraints. For some participants, reverse mortgages represented strategic tools used to maximize home equity and its benefits. For others, it was an option of last resort to which participants turned when faced with the imminent loss of their home. Focusing on reverse mortgages, our analysis suggests way that social inequalities may be reproduced through financial decisions and the unequal landscapes of opportunity in which they are made.

Reverse logistics policy – differences between conservative and innovative reverse logistics management

Directory of Open Access Journals (Sweden)

Alena Klapalová

2013-01-01

Full Text Available One of the of the key barriers that hampers effective and efficient management of reverse flows detected within a number of empirical surveys and case studies focused on reverse logistics and/or return management is business (organisational policy, specifically lack of policy, deficiency in existing policy or inferior policy. Despite this fact, there is a gap in literature which would show some evidence from practice that innovative reverse logistics policy both can pay off and is associated with certain aspects of reverse logistics management. Such proof can have several implications. It can support the call for better understanding and more research of the linkages of reverse logistics with other corporate functions, promote the acceptation of strategic character of reverse logistics and stress the role of RL policy within the rest of overall corporate management.The aim of this paper is to contribute and to enrich the existing body of knowledge concerning the above-mentioned gap through presentation of survey results that was realized in 2012 among managers of 244 Czech firms. The results demonstrate the statistically significant association between the innovativeness of RL policy and profitability of firms, quality of RL planning, perception of RL importance, level of RL knowledge and perception of product innovation importance for firms’ competitiveness and frequency of product innovation. They also reveal statistically significant differences between firms with conservative and innovative RL policy and the perceived existence of some barriers to manage RL.

Effects of the proposed California WaterFix North Delta Diversion on flow reversals and entrainment of juvenile Chinook salmon (Oncorhynchus tshawytscha) into Georgiana Slough and the Delta Cross Channel, northern California

Science.gov (United States)

Perry, Russell W.; Romine, Jason G.; Pope, Adam C.; Evans, Scott D.

2018-02-27

The California Department of Water Resources and Bureau of Reclamation propose new water intake facilities on the Sacramento River in northern California that would convey some of the water for export to areas south of the Sacramento-San Joaquin River Delta (hereinafter referred to as the Delta) through tunnels rather than through the Delta. The collection of water intakes, tunnels, pumping facilities, associated structures, and proposed operations are collectively referred to as California WaterFix. The water intake facilities, hereinafter referred to as the North Delta Diversion (NDD), are proposed to be located on the Sacramento River downstream of the city of Sacramento and upstream of the first major river junction where Sutter Slough branches from the Sacramento River. The NDD can divert a maximum discharge of 9,000 cubic feet per second (ft3/s) from the Sacramento River, which reduces the amount of Sacramento River inflow into the Delta.In this report, we conducted three analyses to investigate the effect of the NDD and its proposed operation on entrainment of juvenile Chinook salmon (Oncorhynchus tshawytscha) into Georgiana Slough and the Delta Cross Channel (DCC). Fish that enter the interior Delta (the network of channels to the south of the Sacramento River) through Georgiana Slough and the DCC survive at lower rates than fish that use other migration routes (Sacramento River, Sutter Slough, and Steamboat Slough). Therefore, fisheries managers were concerned about the extent to which operation of the NDD would increase the proportion of the population entering the interior Delta, which, all else being equal, would lower overall survival through the Delta by increasing the fraction of the population subject to lower survival rates. Operation of the NDD would reduce flow in the Sacramento River, which has the potential to increase the magnitude and duration of reverse flows of the Sacramento River downstream of Georgiana Slough.In the first analysis, we

Prevention of airborne contamination and cross-contamination in germ-free mice by laminar flow

NARCIS (Netherlands)

Waaij, D. van der; Andres, A.H.

1971-01-01

The efficacy of horizontal and vertical laminar flow units (equipped with high-efficiency air filters) in the prevention of cross-contamination between cages and of contamination from outside has been demonstrated. With germ-free mice and using germ-free standard techniques for sterilization and for

Dynamical similarity of geomagnetic field reversals.

Science.gov (United States)

Valet, Jean-Pierre; Fournier, Alexandre; Courtillot, Vincent; Herrero-Bervera, Emilio

2012-10-04

No consensus has been reached so far on the properties of the geomagnetic field during reversals or on the main features that might reveal its dynamics. A main characteristic of the reversing field is a large decrease in the axial dipole and the dominant role of non-dipole components. Other features strongly depend on whether they are derived from sedimentary or volcanic records. Only thermal remanent magnetization of lava flows can capture faithful records of a rapidly varying non-dipole field, but, because of episodic volcanic activity, sequences of overlying flows yield incomplete records. Here we show that the ten most detailed volcanic records of reversals can be matched in a very satisfactory way, under the assumption of a common duration, revealing common dynamical characteristics. We infer that the reversal process has remained unchanged, with the same time constants and durations, at least since 180 million years ago. We propose that the reversing field is characterized by three successive phases: a precursory event, a 180° polarity switch and a rebound. The first and third phases reflect the emergence of the non-dipole field with large-amplitude secular variation. They are rarely both recorded at the same site owing to the rapidly changing field geometry and last for less than 2,500 years. The actual transit between the two polarities does not last longer than 1,000 years and might therefore result from mechanisms other than those governing normal secular variation. Such changes are too brief to be accurately recorded by most sediments.

Evaluation of flow fields on bubble removal and system performance in an ammonium bicarbonate reverse electrodialysis stack

KAUST Repository

Hatzell, Marta C.

2013-11-01

Ammonium bicarbonate has recently been demonstrated to be an excellent thermolytic solution for energy generation in reverse electrodialysis (RED) stacks. However, operating RED stacks at room temperatures can promote gaseous bubble (CO2, NH3) accumulation within the stack, reducing overall system performance. The management and minimization of bubbles formed in RED flow fields is an important operational issue which has yet to be addressed. Flow fields with and without spacers in RED stacks were analyzed to determine how both fluid flow and the buildup and removal of bubbles affected performance. In the presence of a spacer, the membrane resistance increased by ~50Ω, resulting in a decrease in power density by 30% from 0.140Wm-2 to 0.093Wm-2. Shorter channels reduced concentration polarization affects, and resulted in 3-23% higher limiting current density. Gas accumulation was minimized through the use of short vertically aligned channels, and consequently the amount of the membrane area covered by bubbles was reduced from ~20% to 7% which caused a 12% increase in power density. As ammonium bicarbonate RED systems are scaled up, attention to channel aspect ratio, length, and alignment will enable more stable performance. © 2013 Elsevier B.V.

The Role of IT Solutions in Reverse Logistics Management Support

African Journals Online (AJOL)

pc

2018-03-05

Mar 5, 2018 ... Keywords-reverse logistics, return flow, IT solutions, EDI, Barcodes, ... and controlling the efficiency, performance, cost flow of raw materials ..... questions, for the further analysis only these were chosen that are strongly ...

Radiometric and paleomagnetic evidence for the Emperor reversed polarity event at 0.46 ± 0.05 M.Y. in basalt lava flows from the eastern Snake River Plain, Idaho

Science.gov (United States)

Champion, Duane E.; Dalrymple, G. Brent; Kuntz, Mel A.

1981-01-01

K-Ar and paleomagnetic data from cores through a sequence of basalt flows in the eastern Snake River Plain provide evidence for a brief (0.005 to 0.01 m.y.) reversal of the geomagnetic field 0.46 ± 0.05 m.y. ago. This reversed polarity event has also been found in sea-floor magnetic anomalies and in sediment cores and is probably the Emperor event of Ryan [1972].

Index-Based Assessment of Voltage Rise and Reverse Power Flow Phenomena in a Distribution Feeder Under High PV Penetration

DEFF Research Database (Denmark)

Hasheminamin, Maryam; Agelidis, Vassilios G.; Salehi, Vahid

2015-01-01

-based methodology for assessing the impact of high solar PV generation, considering the reverse power flow and voltage rise phenomena. Indices are defined that link these two phenomena and their impact on the voltage profile across the feeder. This assessment relies on detailed modeling of the network and the solar......The proliferation of photovoltaic (PV) generation in low- and medium-voltage distribution networks is expected to continue. Qualified studies can quantify adverse impacts of high PV penetration on distribution networks and assist utilities in decision making. This paper proposes an index...

Formalized Planning and Its Connection With the Development of Reverse Logistics: the Case of Services

Directory of Open Access Journals (Sweden)

Radoslav Škapa

2014-01-01

Full Text Available The best-in-class companies are able to retrieve 64 per cent of the original value of reverse flows, whereas it is only 12.5 per cent in average companies. Thus, reverse logistics is a challenge that may bring additional benefits. The article analyzes the planning range of reverse logistics in the Czech service companies, and it further notes the relations between planning and other characteristics of a company. Our results indicate that the ability to recognize different connections of reverse flows in business (opportunities, threats as well as strengths and weaknesses is one of the important factors that affect the advancement of reverse logistics in companies.

Reverse convection in helium and other fluids in the high speed rotating frame: negative and positive buoyancy effects

International Nuclear Information System (INIS)

Igra, R.; Scurlock, R.G.; Wu, Y.Y.

1986-01-01

Experimental studies of thermo-syphon flows in radial tubes and loops between the axis and the periphery of a rotating helium cryostat have shown that when heat is supplied at an intermediate radius, the heat is carried radially inwards as A flow and radially outwards as B flow. The results with helium suggest that while the steady state patterns of the A and B flows are complex, the heat is divided approximately equally between the conventional A flow and the reverse B flow. A model of convective heating in the rotating frame is presented and two necessary conditions for reverse convection are identified and discussed. The model predicts reverse convection in liquid nitrogen and this is confirmed by experimental measurement. An array of radial ducts is proposed for the cooling of a superconducting AC generator in order to counter the effects of reverse convection in the helium refrigerant

The ATPG Attack for Reverse Engineering of Combinational Hybrid Custom-Programmable Circuits

Science.gov (United States)

2017-03-23

Introduction The widely practiced horizontal integrated circuit supply chain exposes a design to various types of attacks including the reverse engineering ...STT_CMOS designs for reverse- engineering prevention, DAC 2016. [5] M. E. Massad and et. al. Integrated circuit (IC) decamouflaging: reverse...The ATPG Attack for Reverse Engineering of Combinational Hybrid Custom-Programmable Circuits Raza Shafiq Hamid Mahmoodi Houman Homayoun Hassan

Reversible airfoils for stopped rotors in high speed flight

International Nuclear Information System (INIS)

Niemiec, Robert; Jacobellis, George; Gandhi, Farhan

2014-01-01

This study starts with the design of a reversible airfoil rib for stopped-rotor applications, where the sharp trailing-edge morphs into the rounded leading-edge, and vice-versa. A NACA0012 airfoil is approximated in a piecewise linear manner and straight, rigid outer profile links used to define the airfoil contour. The end points of the profile links connect to control links, each set on a central actuation rod via an offset. Chordwise motion of the actuation rod moves the control and the profile links and reverses the airfoil. The paper describes the design methodology and evolution of the final design, based on which two reversible airfoil ribs were fabricated and used to assemble a finite span reversible rotor/wing demonstrator. The profile links were connected by Aluminum strips running in the spanwise direction which provided stiffness as well as support for a pre-tensioned elastomeric skin. An inter-rib connector with a curved-front nose piece supports the leading-edge. The model functioned well and was able to reverse smoothly back-and-forth, on application and reversal of a voltage to the motor. Navier–Stokes CFD simulations (using the TURNS code) show that the drag coefficient of the reversible airfoil (which had a 13% maximum thickness due to the thickness of the profile links) was comparable to that of the NACA0013 airfoil. The drag of a 16% thick elliptical airfoil was, on average, about twice as large, while that of a NACA0012 in reverse flow was 4–5 times as large, even prior to stall. The maximum lift coefficient of the reversible airfoil was lower than the elliptical airfoil, but higher than the NACA0012 in reverse flow operation. (paper)

Determination of gallic acid with rhodanine by reverse flow injection analysis using simplex optimization.

Science.gov (United States)

Phakthong, Wilaiwan; Liawruangrath, Boonsom; Liawruangrath, Saisunee

2014-12-01

A reversed flow injection (rFI) system was designed and constructed for gallic acid determination. Gallic acid was determined based on the formation of chromogen between gallic acid and rhodanine, resulting in a colored product with a λmax at 520 nm. The optimum conditions for determining gallic acid were also investigated. Optimizations of the experimental conditions were carried out based on the so-call univariate method. The conditions obtained were 0.6% (w/v) rhodanine, 70% (v/v) ethanol, 0.9 mol L(-1) NaOH, 2.0 mL min(-1) flow rate, 75 μL injection loop and 600 cm mixing tubing length, respectively. Comparative optimizations of the experimental conditions were also carried out by multivariate or simplex optimization method. The conditions obtained were 1.2% (w/v) rhodanine, 70% (v/v) ethanol, 1.2 mol L(-1) NaOH, flow rate 2.5 mL min(-1), 75 μL injection loop and 600 cm mixing tubing length, respectively. It was found that the optimum conditions obtained by the former optimization method were mostly similar to those obtained by the latter method. The linear relationship between peak height and the concentration of gallic acid was obtained over the range of 0.1-35.0 mg L(-1) with the detection limit 0.081 mg L(-1). The relative standard deviations were found to be in the ranges 0.46-1.96% for 1, 10, 30 mg L(-1) of gallic acid (n=11). The method has the advantages of simplicity extremely high selectivity and high precision. The proposed method was successfully applied to the determination of gallic acid in longan samples without interferent effects from other common phenolic compounds that might be present in the longan samples collected in northern Thailand. Copyright © 2014 Elsevier B.V. All rights reserved.

Amarogentin Induces Apoptosis of Liver Cancer Cells via Upregulation of p53 and Downregulation of Human Telomerase Reverse Transcriptase in Mice

Science.gov (United States)

Li, Runqin; Zhang, Yinglin

2016-01-01

Background and Objective: Amarogentin has been reported to have a preventive effect on liver cancer via inducing cancer cell apoptosis. We attempted to elucidate the roles of p53-associated apoptosis pathways in the chemopreventive mechanism of amarogentin. The findings of this study will facilitate the development of a novel supplementary strategy for the treatment of liver cancer. Materials and Methods: The purity of amarogentin was assessed by high-performance liquid chromatography. The inhibitory ratios of the liver cell lines were determined using a Cell Counting Kit-8 following treatment with a gradient concentration of amarogentin. Cell apoptosis was detected by flow cytometry using annexin V-fluorescein isothiocyanate/propidium iodide kits. The gene and protein expression of p53-associated molecules, such as Akt, human telomerase reverse transcriptase, RelA, and p38, was detected by real-time quantitative polymerase chain reaction, Western blotting, and immunohistochemical staining in liver cancer cells and mouse tumor tissues after treatment with amarogentin. Results: The inhibitory effect of amarogentin on cell proliferation was more obvious in liver cancer cells, and amarogentin was more likely to induce the apoptosis of liver cancer cells than that of normal liver cells. The gene and protein expression levels of Akt, RelA, and human telomerase reverse transcriptase were markedly higher in the control group than in the preventive group and treatment groups. Only the expression of human telomerase reverse transcriptase was downregulated, accompanied by the upregulation of p53. Conclusion: The results of our study suggest that amarogentin promotes apoptosis of liver cancer cells by the upregulation of p53 and downregulation of human telomerase reverse transcriptase and prevents the malignant transformation of these cells. PMID:27402632

Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling

Energy Technology Data Exchange (ETDEWEB)

Gao, Fu [Department of Vascular Surgery, Peking University People’s Hospital, Beijing (China); Chambon, Pierre [Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS UMR7104, INSERM U596, ULP, Collége de France) and Institut Clinique de la Souris, ILLKIRCH, Strasbourg (France); Tellides, George [Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT (United States); Kong, Wei [Department of Physiology and Pathophysiology, Basic Medical College of Peking University, Beijing (China); Zhang, Xiaoming, E-mail: rmygxgwk@163.com [Department of Vascular Surgery, Peking University People’s Hospital, Beijing (China); Li, Wei [Department of Vascular Surgery, Peking University People’s Hospital, Beijing (China)

2014-11-07

Highlights: • TGF-β signaling in SMC contributes to the flow-induced vascular remodeling. • Disruption of TGF-β signaling in SMC can prevent this process. • Targeting SM-specific Tgfbr2 could be a novel therapeutic strategy for vascular remodeling. - Abstract: Transforming growth factor-β (TGF-β) signaling has been prominently implicated in the pathogenesis of vascular remodeling, especially the initiation and progression of flow-induced vascular remodeling. Smooth muscle cells (SMCs) are the principal resident cells in arterial wall and are critical for arterial remodeling. However, the role of TGF-β signaling in SMC for flow-induced vascular remodeling remains unknown. Therefore, the goal of our study was to determine the effect of TGF-β pathway in SMC for vascular remodeling, by using a genetical smooth muscle-specific (SM-specific) TGF-β type II receptor (Tgfbr2) deletion mice model. Mice deficient in the expression of Tgfbr2 (MyhCre.Tgfbr2{sup f/f}) and their corresponding wild-type background mice (MyhCre.Tgfbr2{sup WT/WT}) underwent partial ligation of left common carotid artery for 1, 2, or 4 weeks. Then the carotid arteries were harvested and indicated that the disruption of Tgfbr2 in SMC provided prominent inhibition of vascular remodeling. And the thickening of carotid media, proliferation of SMC, infiltration of macrophage, and expression of matrix metalloproteinase (MMP) were all significantly attenuated in Tgfbr2 disruption mice. Our study demonstrated, for the first time, that the TGF-β signaling in SMC plays an essential role in flow-induced vascular remodeling and disruption can prevent this process.

Magnetic reversals from planetary dynamo waves.

Science.gov (United States)

Sheyko, Andrey; Finlay, Christopher C; Jackson, Andrew

2016-11-24

A striking feature of many natural dynamos is their ability to undergo polarity reversals. The best documented example is Earth's magnetic field, which has reversed hundreds of times during its history. The origin of geomagnetic polarity reversals lies in a magnetohydrodynamic process that takes place in Earth's core, but the precise mechanism is debated. The majority of numerical geodynamo simulations that exhibit reversals operate in a regime in which the viscosity of the fluid remains important, and in which the dynamo mechanism primarily involves stretching and twisting of field lines by columnar convection. Here we present an example of another class of reversing-geodynamo model, which operates in a regime of comparatively low viscosity and high magnetic diffusivity. This class does not fit into the paradigm of reversal regimes that are dictated by the value of the local Rossby number (the ratio of advection to Coriolis force). Instead, stretching of the magnetic field by a strong shear in the east-west flow near the imaginary cylinder just touching the inner core and parallel to the axis of rotation is crucial to the reversal mechanism in our models, which involves a process akin to kinematic dynamo waves. Because our results are relevant in a regime of low viscosity and high magnetic diffusivity, and with geophysically appropriate boundary conditions, this form of dynamo wave may also be involved in geomagnetic reversals.

Thaw flow control for liquid heat transport systems

Science.gov (United States)

Kirpich, Aaron S.

1989-01-01

In a liquid metal heat transport system including a source of thaw heat for use in a space reactor power system, the thaw flow throttle or control comprises a fluid passage having forward and reverse flow sections and a partition having a plurality of bleed holes therein to enable fluid flow between the forward and reverse sections. The flow throttle is positioned in the system relatively far from the source of thaw heat.

Reverse osmosis and its use at the nuclear power plants. Purification of primary circuit coolant by the means of reverse osmosis

International Nuclear Information System (INIS)

Kus, Pavel; Vonkova, Katerina; Kunesova, Katerina; Bartova, Sarka; Skala, Martin; Moucha, Tomáš

2014-01-01

This contribution is focused on the use of membrane technologies (e.g. reverse osmosis) for the primary coolant purification at the nuclear power plants. Currently, boric acid present in the primary coolant is preconcentrated at the evaporators, but their operation is very inefficient and expensive. Therefore, reverse osmosis was proposed as one of promising methods possibly replacing evaporators. The aim of the purification process is to achieve boric acid solution of a defined concentration (40 g/l) in the retentate stream in order to recycle it and reuse it in the primary circuit. Additionally, permeate flow should consist solely of pure water. To study the efficiency of several reverse osmosis modulus in the boric acid removal form the water solutions, experimental apparatus was constructed in our laboratory. It consists of the solution reservoir, pump and reverse osmosis modulus. The arrangement of experiments was batch and the retentate flow was refluxed to the feed solution. Several modulus of commercial reverse osmosis membranes were tested. The feed solution contained various concentrations of H 3 BO 3 , KOH, LiOH and NH 3 in order to simulate real primary coolant composition. Based on the experimental results, mathematical model was developed in order to optimize experimental conditions for the best results in primary coolant purification and boric acid preconcentration. (author)

Operating a redox flow battery with a negative electrolyte imbalance

Science.gov (United States)

Pham, Quoc; Chang, On; Durairaj, Sumitha

2015-03-31

Loss of flow battery electrode catalyst layers during self-discharge or charge reversal may be prevented by establishing and maintaining a negative electrolyte imbalance during at least parts of a flow battery's operation. Negative imbalance may be established and/or maintained actively, passively or both. Actively establishing a negative imbalance may involve detecting an imbalance that is less negative than a desired threshold, and processing one or both electrolytes until the imbalance reaches a desired negative level. Negative imbalance may be effectively established and maintained passively within a cell by constructing a cell with a negative electrode chamber that is larger than the cell's positive electrode chamber, thereby providing a larger quantity of negative electrolyte for reaction with positive electrolyte.

Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe.

Science.gov (United States)

Margalef, Pol; Kotsantis, Panagiotis; Borel, Valerie; Bellelli, Roberto; Panier, Stephanie; Boulton, Simon J

2018-01-25

Telomere maintenance critically depends on the distinct activities of telomerase, which adds telomeric repeats to solve the end replication problem, and RTEL1, which dismantles DNA secondary structures at telomeres to facilitate replisome progression. Here, we establish that reversed replication forks are a pathological substrate for telomerase and the source of telomere catastrophe in Rtel1 -/- cells. Inhibiting telomerase recruitment to telomeres, but not its activity, or blocking replication fork reversal through PARP1 inhibition or depleting UBC13 or ZRANB3 prevents the rapid accumulation of dysfunctional telomeres in RTEL1-deficient cells. In this context, we establish that telomerase binding to reversed replication forks inhibits telomere replication, which can be mimicked by preventing replication fork restart through depletion of RECQ1 or PARG. Our results lead us to propose that telomerase inappropriately binds to and inhibits restart of reversed replication forks within telomeres, which compromises replication and leads to critically short telomeres. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Automatic Error Recovery in Robot Assembly Operations Using Reverse Execution

DEFF Research Database (Denmark)

Laursen, Johan Sund; Schultz, Ulrik Pagh; Ellekilde, Lars-Peter

2015-01-01

, in particular for small-batch productions. As an alternative, we propose a system for automatically handling certain classes of errors instead of preventing them. Specifically, we show that many operations can be automatically reversed. Errors can be handled through automatic reverse execution of the control...... program to a safe point, from which forward execution can be resumed. This paper describes the principles behind automatic reversal of robotic assembly operations, and experimentally demonstrates the use of a domain-specific language that supports automatic error handling through reverse execution. Our...

Flow regimes

International Nuclear Information System (INIS)

Kh'yuitt, G.

1980-01-01

An introduction into the problem of two-phase flows is presented. Flow regimes arizing in two-phase flows are described, and classification of these regimes is given. Structures of vertical and horizontal two-phase flows and a method of their identification using regime maps are considered. The limits of this method application are discussed. The flooding phenomena and phenomena of direction change (flow reversal) of the flow and interrelation of these phenomena as well as transitions from slug regime to churn one and from churn one to annular one in vertical flows are described. Problems of phase transitions and equilibrium are discussed. Flow regimes in tubes where evaporating liquid is running, are described [ru

REVERSIBLE VENTILATION SYSTEM FOR ADMINISTRATIVE BUILDINGS

Directory of Open Access Journals (Sweden)

Valery Yu. Kravchuk

2017-01-01

Full Text Available Abstract. Objectives To consider the possibility of applying the principle of reversing air flows for a centralised ventilation system; to develop a specific scheme for air exchange reversible ventilation, which will take into account the peculiarities of the microclimate of administrative buildings; to select the type of filling of the air-permeable element and justify this choice; to determine the conditions for changing the direction of air movement in the ventilation system and the area of its application; to form a list of equipment necessary for the operation of such a system; to consider the influence of supply and exhaust devices on the heat and humidity regime of claddings. Methods  To achieve this goal, the published thematic material was reviewed and a patent search carried out using Russian and European databases. Data on mathematical modelling of filtration in porous media and experimental results were used. A method for ventilating rooms in administrative building using the reversal of movement of supply and exhaust air streams along the same channels was applied. Results  Schemas for reversible ventilation systems are presented and their modes of operation considered. It is established that the idea of reversing ventilation flows has not yet been applied in the development of centralised ventilation systems. Based on these published materials, it was concluded that the proposed design of supply and exhaust devices can be used in practice. An original air exchange scheme for the ventilation of administrative buildings and design of supply and exhaust devices for this system are proposed. The conditions for changing the operating modes of the system and the scope of its application are determined. Conclusion The use of the proposed ventilation system allows normative air exchange to be provided without using a supply unit during the cold season. This application of airflow reversal allows the potential of natural forces to be used

EFFECT OF ION ∇ B DRIFT DIRECTION ON TURBULENCE FLOW AND FLOW SHEAR

International Nuclear Information System (INIS)

FENZI, C; McKEE, G.R; BURRELL, K.H; CARLSTROM, T.N; FONCK, R.J; GROEBNER, R.J

2003-01-01

The divertor magnetic geometry has a significant effect on the poloidal flow and resulting flow shear of turbulence in the outer region of L-mode tokamak plasmas, as determined via two-dimensional measurements of density fluctuations with Beam Emission Spectroscopy on DIII-D. Plasmas with similar parameters, except that in one case the ion (del)B drift points towards the divertor X-point (lower single-null, LSN), and in the other case, the ion (del)B drift points away from the divertor X-point (upper single-null, USN), are compared. Inside of r/a=0.9, the turbulence characteristics (amplitude, flow direction, correlation lengths) are similar in both cases, while near r/a=0.92, a dramatic reversal of the poloidal flow of turbulence relative to the core flow direction is observed in plasmas with the ion (del)B drift pointing towards the divertor X-point. No such flow reversal is observed in plasmas with the ion (del)B drift pointing away from the divertor X-point. This poloidal flow reversal results in a significantly larger local shear in the poloidal turbulence flow velocity in plasmas with the ion (del)B drift pointing towards the divertor X-point. Additionally, these plasmas locally exhibit significant dispersion, with two distinct and counter-propagating turbulence modes. Likewise, the radial correlation length of the turbulence is reduced in these plasmas, consistent with biorthogonal decomposition measurements of dominant turbulence structures. The naturally occurring turbulence flow shear in these LSN plasmas may facilitate the LH transition that occurs at an input power of roughly one-half to one-third that of corresponding plasmas with the ion (del)B drift pointing away from the X-point

Reverse Logistics in Food Supply Chains

NARCIS (Netherlands)

Zeimpekis, V.; Bloemhof, J.M.; Bourlakis, M.

2014-01-01

Reverse logistics can be defined as the process of planning, implementing, and controlling the flow of raw materials, in-process inventory, and finished goods from the point of consumption to the point of origin for the purpose of recapturing value or proper disposal. In environmental and economic

Cross flow filtration for radwaste applications reverse osmosis demonstration case studies

International Nuclear Information System (INIS)

Malkmus, D.

1995-01-01

Today's radwaste economic and regulatory scenarios signify the importance in the improvement of operational practices to reduce generator liabilities. This action is largely due to the rising cost dealing with burial sites and the imposed waste volume restriction. To control the economical burdens associated with waste burial and to comply with stricter environmental regulations, NPP's are attempting to modify their radwaste system(s) design and operating philosophy by placing a major emphasis on waste volume reduction and processing techniques. The utilization of reverse osmosis technology as a means for treatment of process and wastewater streams in the nuclear power industry has been investigated for many years. This paper will outline reverse osmosis theory and highlight performance data for process and waste stream purification applications. Case studies performed at 5 nuclear plants have been outlined. The demonstrations were performed on a widely variety of process stream for both a PWR and BWR application. The data provided by the pilot systems, the equipment design, and the economical impact a reverse osmosis unit will have on producing treated (high purity) are as follows

Characterization of Passive Flow-Actuated Microflaps Inspired by Shark Skin for Separation Control

Science.gov (United States)

Morris, Jackson; Devey, Sean; Lang, Amy; Hubner, Paul

2017-11-01

Thanks to millions of years of natural selection, sharks have evolved into quick apex predators. Previous research has proven shark skin to reduce flow separation, which would result in lower pressure drag. Mako shark skin is made up of microscopic scales on the order of 0.2 mm in size. These scales are hypothesized to be a flow control mechanism, capable of being passively actuated by reversed flow. We believe shark scales are strategically sized to interact with the lower 5 percent of the boundary layer, where reversed flow occurs near the wall. Previous wind tunnel research has shown that it is possible to passively actuate 2D flaps in the lower regions of the boundary layer. This research aims to identify reverse flow conditions that will cause small 3D flaps to actuate. Several sets of microflaps (about 4 mm in length) geometrically similar to shark scales were 3D printed. These microflaps were tested in a low-speed wind tunnel in various reverse flow conditions. Microflaps were observed to be actuated by the reversing flow and flow conditions were characterized using a hot-wire probe. These microflaps have the potential to mimic the mako shark type of flow control in air, passively actuated by reverse flow conditions. This research was supported by Boeing, the US Army, and the National Science Foundation REU program.

Effect of flow velocity, substrate concentration and hydraulic cleaning on biofouling of reverse osmosis feed channels

KAUST Repository

Radu, Andrea I.

2012-04-01

A two-dimensional mathematical model coupling fluid dynamics, salt and substrate transport and biofilm development in time was used to investigate the effects of cross-flow velocity and substrate availability on biofouling in reverse osmosis (RO)/nanofiltration (NF) feed channels. Simulations performed in channels with or without spacer filaments describe how higher liquid velocities lead to less overall biomass amount in the channel by increasing the shear stress. In all studied cases at constant feed flow rate, biomass accumulation in the channel reached a steady state. Replicate simulation runs prove that the stochastic biomass attachment model does not affect the stationary biomass level achieved and has only a slight influence on the dynamics of biomass accumulation. Biofilm removal strategies based on velocity variations are evaluated. Numerical results indicate that sudden velocity increase could lead to biomass sloughing, followed however by biomass re-growth when returning to initial operating conditions. Simulations show particularities of substrate availability in membrane devices used for water treatment, e.g., the accumulation of rejected substrates at the membrane surface due to concentration polarization. Interestingly, with an increased biofilm thickness, the overall substrate consumption rate dominates over accumulation due to substrate concentration polarization, eventually leading to decreased substrate concentrations in the biofilm compared to bulk liquid. © 2012 Elsevier B.V.

AN OVERVIEW ON RETAIL REVERSE LOGISTICS

Directory of Open Access Journals (Sweden)

Ioana Olariu

2014-07-01

Full Text Available This article is a theoretical approach on retail reverse logistics. Environmental concern and the current marketing strategy have spurred retailers to implement strategies to facilitate product returns from end customers. Reverse logistics, indicating the process of this return flow, encompasses such activities as the movement of returned products, facilities to accommodate returned items, and overall remedy process for returned items. The retail industry, under great competitive pressure, has used return policies as a competitive weapon. Grocery retailers were the first to begin to focus serious attention on the problem of returns and to develop reverse logistics innovations. Grocery retailers first developed innovations such as reclamation centers. Reclamation centers, in turn, led to the establishment of centralized return centers. Centralizing returns has led to significant benefits for most firms that have implemented them. Over the last several years, retailers have consolidated. Now, more than ever, reverse logistics is seen as being important. This reverse distribution activity can be crucial to the survival of companies, because the permanent goodwill of the company is at stake. Businesses succeed because they respond to both external and internal changes and adjust in an effective manner to remain competitive.

Effects of dipyridamole and aminophylline on hemodynamics, regional myocardial blood flow and thallium-201 washout in the setting of a critical coronary stenosis

International Nuclear Information System (INIS)

Granato, J.E.; Watson, D.D.; Belardinelli, L.; Cannon, J.M.; Beller, G.A.

1990-01-01

Experiments were performed to characterize the interaction of intravenous dipyridamole and aminophylline on thallium-201 transport kinetics, regional myocardial blood flow and systemic hemodynamics in the presence of a critical coronary artery stenosis. In 12 dogs with a critical left anterior descending coronary artery stenosis, arterial pressure decreased from a mean value (+/- SEM) of 107 +/- 6 to 94 +/- 3 mm Hg and distal left anterior descending artery pressure decreased from 70 +/- 7 to 55 +/- 4 mm Hg after intravenous administration of dipyridamole. In the left anterior descending perfusion zone, the endocardial/epicardial flow ratio decreased from 0.70 to 0.36 and the intrinsic thallium washout rate was significantly prolonged. Intravenous aminophylline reversed the dipyridamole-induced systemic hypotension and transmural coronary steal and restored the thallium washout rate to baseline values. In six other dogs, aminophylline alone resulted in no alterations in systemic and coronary hemodynamics or regional myocardial blood flow. As expected, dipyridamole-induced vasodilation and coronary steal were prevented by aminophylline pretreatment. These data show that in a canine model of partial coronary stenosis, systemic hypotension, adverse regional flow effects and prolonged thallium-201 washout consequent to intravenously administered dipyridamole are promptly reversed by intravenous aminophylline administration. Aminophylline alone had no significant hemodynamic and coronary flow effects. This study provides further insight into the altered thallium kinetics occurring as a consequence of dipyridamole-induced vasodilation and suggests that the prompt reversal of symptoms and signs of ischemia with aminophylline in patients receiving intravenous dipyridamole for clinical imaging studies probably reflects the reversal of transmural coronary steal

Leading-edge flow criticality as a governing factor in leading-edge vortex initiation in unsteady airfoil flows

Science.gov (United States)

Ramesh, Kiran; Granlund, Kenneth; Ol, Michael V.; Gopalarathnam, Ashok; Edwards, Jack R.

2018-04-01

A leading-edge suction parameter (LESP) that is derived from potential flow theory as a measure of suction at the airfoil leading edge is used to study initiation of leading-edge vortex (LEV) formation in this article. The LESP hypothesis is presented, which states that LEV formation in unsteady flows for specified airfoil shape and Reynolds number occurs at a critical constant value of LESP, regardless of motion kinematics. This hypothesis is tested and validated against a large set of data from CFD and experimental studies of flows with LEV formation. The hypothesis is seen to hold except in cases with slow-rate kinematics which evince significant trailing-edge separation (which refers here to separation leading to reversed flow on the aft portion of the upper surface), thereby establishing the envelope of validity. The implication is that the critical LESP value for an airfoil-Reynolds number combination may be calibrated using CFD or experiment for just one motion and then employed to predict LEV initiation for any other (fast-rate) motion. It is also shown that the LESP concept may be used in an inverse mode to generate motion kinematics that would either prevent LEV formation or trigger the same as per aerodynamic requirements.

Reverse osmosis water purification system

Science.gov (United States)

Ahlstrom, H. G.; Hames, P. S.; Menninger, F. J.

1986-01-01

A reverse osmosis water purification system, which uses a programmable controller (PC) as the control system, was designed and built to maintain the cleanliness and level of water for various systems of a 64-m antenna. The installation operates with other equipment of the antenna at the Goldstone Deep Space Communication Complex. The reverse osmosis system was designed to be fully automatic; with the PC, many complex sequential and timed logic networks were easily implemented and are modified. The PC monitors water levels, pressures, flows, control panel requests, and set points on analog meters; with this information various processes are initiated, monitored, modified, halted, or eliminated as required by the equipment being supplied pure water.

Cell cycle checkpoints: reversible when possible, irreversible when needed

NARCIS (Netherlands)

Krenning, L.

2015-01-01

Cell cycle checkpoints are reversible in nature, and can prevent progression into the next cell cycle phase if needed. In the case of DNA damage, cells can prevent progression from G1 into S phase, and from G2 into mitosis in the presence of DNA double strand breaks. Following DNA repair, these

Concepts of self-acting circulation loops for downward heat transfer (reverse thermosiphons)

International Nuclear Information System (INIS)

Dobriansky, Y.

2011-01-01

This paper reviews the scientific and technical knowledge related to general self-acting flow loops (thermosiphons and heat pipes) that transmit heat upwards and self-acting reverse flow loops that transmit heat downwards. This paper classifies the heat and mass transfer processes that take place in general flow loops and analyses the nomenclature applied in the literature. It also presents the principles of operation of sixteen reverse flow loops; four of the loops are powered by an external source of energy, while the remaining loops are self-acting. Of the self-acting loops, vapor was used for heat transfer in seven of them and liquid was used in the remaining ones. Based on the available research results, a list of the advantages and disadvantages of both types of loops is presented.

Convective flow reversal in self-powered enzyme micropumps.

Science.gov (United States)

Ortiz-Rivera, Isamar; Shum, Henry; Agrawal, Arjun; Sen, Ayusman; Balazs, Anna C

2016-03-08

Surface-bound enzymes can act as pumps that drive large-scale fluid flows in the presence of their substrates or promoters. Thus, enzymatic catalysis can be harnessed for “on demand” pumping in nano- and microfluidic devices powered by an intrinsic energy source. The mechanisms controlling the pumping have not, however, been completely elucidated. Herein, we combine theory and experiments to demonstrate a previously unreported spatiotemporal variation in pumping behavior in urease-based pumps and uncover the mechanisms behind these dynamics. We developed a theoretical model for the transduction of chemical energy into mechanical fluid flow in these systems, capturing buoyancy effects due to the solution containing nonuniform concentrations of substrate and product. We find that the qualitative features of the flow depend on the ratios of diffusivities δ=D(P)/D(S) and expansion coefficients β=β(P)/β(S) of the reaction substrate (S) and product (P). If δ>1 and δ>β (or if δself-powered fluidic devices.

Sol-gel open tubular ODS columns with reversed electroosmotic flow for capillary electrochromatography.

Science.gov (United States)

Hayes, J D; Malik, A

2001-03-01

Sol-gel chemistry was successfully used for the fabrication of open tubular columns with surface-bonded octadecylsilane (ODS) stationary-phase coating for capillary electrochromatography (OT-CEC). Following column preparations, a series of experiments were performed to investigate the performance of the sol-gel coated ODS columns in OT-CEC. The incorporation of N-octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride as one of the sol-gel precursors played an important role in the electrochromatographic performance of the prepared columns. This chemical reagent possesses a chromatographically favorable, bonded ODS moiety, in conjunction with three methoxy groups allowing for sol-gel reactivity. In addition, a positively charged nitrogen atom is present in the molecular structure of this reagent and provides a positively charged capillary surface responsible for the reversed electroosmotic flow (EOF) in the columns during CEC operation. Comparative studies involving the EOF within such sol-gel ODS coated and uncoated capillaries were performed using acetonitrile and methanol as the organic modifiers in the mobile phase. The use of a deactivating reagent, phenyldimethylsilane, in the sol-gel solution was evaluated. Efficiency values of over 400,000 theoretical plates per meter were achieved in CEC on a 64 cm x 25 microm i.d. sol-gel ODS open tubular column. Test mixtures of polycyclic aromatic hydrocarbons, benzene derivatives, and aromatic aldehydes and ketones were used to evaluate the CEC performances of both nondeactivated and deactivated open tubular sol-gel columns. The effects of mobile-phase organic modifier contents and pH on EOF in such columns were evaluated. The prepared sol-gel ODS columns are characterized by switchable electroosmotic flow. A pH value of approximately 8.5 was found correspond to the isoelectric point for the prepared sol-gel ODS coatings.

Performance and Adaptive Surge-Preventing Acceleration Prediction of a Turboshaft Engine under Inlet Flow Distortion

Directory of Open Access Journals (Sweden)

Cao Dalu

2017-01-01

Full Text Available The intention of this paper is to research the inlet flow distortion influence on overall performance of turboshaft engine and put forward a method called Distortion Factor Item (DFI to improve the fuel supply plan for surge-preventing acceleration when turboshaft engine suddenly encounters inlet flow distortion. Based on the parallel compressor theory, steady-state and transition-state numerical simulation model of turboshaft engine with sub-compressor model were established for researching the influence of inlet flow distortion on turboshaft engine. This paper made a detailed analysis on the compressor operation from the aspects of performance and stability, and then analyzed the overall performance and dynamic response of the whole engine under inlet flow distortion. Improved fuel supply plan with DFI method was applied to control the acceleration process adaptively when encountering different inlet flow distortion. Several simulation examples about extreme natural environments were calculated to testify DFI method’s environmental applicability. The result shows that the inlet flow distortion reduces the air inflow and decreases the surge margin of compressor, and increase the engine exhaust loss. Encountering inlet flow distortion has many adverse influences such as sudden rotor acceleration, turbine inlet temperature rise and power output reduction. By using improved fuel supply plan with DFI, turboshaft engine above-idle acceleration can avoid surge effectively under inlet flow distortion with environmental applicability.

Neutrophil Reverse Migration Becomes Transparent with Zebrafish

Directory of Open Access Journals (Sweden)

Taylor W. Starnes

2012-01-01

Full Text Available The precise control of neutrophil-mediated inflammation is critical for both host defense and the prevention of immunopathology. In vivo imaging studies in zebrafish, and more recently in mice, have made the novel observation that neutrophils leave a site of inflammation through a process called neutrophil reverse migration. The application of advanced imaging techniques to the genetically tractable, optically transparent zebrafish larvae was critical for these advances. Still, the mechanisms underlying neutrophil reverse migration and its effects on the resolution or priming of immune responses remain unclear. Here, we review the current knowledge of neutrophil reverse migration, its potential roles in host immunity, and the live imaging tools that make zebrafish a valuable model for increasing our knowledge of neutrophil behavior in vivo.

Rotating Reverse-Osmosis for Water Purification

Science.gov (United States)

Lueptow, RIchard M.

2004-01-01

A new design for a water-filtering device combines rotating filtration with reverse osmosis to create a rotating reverse- osmosis system. Rotating filtration has been used for separating plasma from whole blood, while reverse osmosis has been used in purification of water and in some chemical processes. Reverse- osmosis membranes are vulnerable to concentration polarization a type of fouling in which the chemicals meant not to pass through the reverse-osmosis membranes accumulate very near the surfaces of the membranes. The combination of rotating filtration and reverse osmosis is intended to prevent concentration polarization and thereby increase the desired flux of filtered water while decreasing the likelihood of passage of undesired chemical species through the filter. Devices based on this concept could be useful in a variety of commercial applications, including purification and desalination of drinking water, purification of pharmaceutical process water, treatment of household and industrial wastewater, and treatment of industrial process water. A rotating filter consists of a cylindrical porous microfilter rotating within a stationary concentric cylindrical outer shell (see figure). The aqueous suspension enters one end of the annulus between the inner and outer cylinders. Filtrate passes through the rotating cylindrical microfilter and is removed via a hollow shaft. The concentrated suspension is removed at the end of the annulus opposite the end where the suspension entered.

Hypogenetic chaotic jerk flows

International Nuclear Information System (INIS)

Li, Chunbiao; Sprott, Julien Clinton; Xing, Hongyan

2016-01-01

Removing the amplitude or polarity information in the feedback loop of a jerk structure shows that special nonlinearities with partial information in the variable can also lead to chaos. Some striking properties are found for this kind of hypogenetic chaotic jerk flow, including multistability of symmetric coexisting attractors from an asymmetric structure, hidden attractors with respect to equilibria but with global attraction, easy amplitude control, and phase reversal which is convenient for chaos applications. - Highlights: • Hypogenetic chaotic jerk flows with incomplete feedback of amplitude or polarity are obtained. • Multistability of symmetric coexisting attractors from an asymmetric structure is found. • Some jerk systems have hidden attractors with respect to equilibria but have global attraction. • These chaotic jerk flows have the properties of amplitude control and phase reversal.

Reversal of interlaminar signal between sensory and memory processing in monkey temporal cortex.

Science.gov (United States)

Takeuchi, Daigo; Hirabayashi, Toshiyuki; Tamura, Keita; Miyashita, Yasushi

2011-03-18

The primate temporal cortex implements visual long-term memory. However, how its interlaminar circuitry executes cognitive computations is poorly understood. Using linear-array multicontact electrodes, we simultaneously recorded unit activities across cortical layers in the perirhinal cortex of macaques performing a pair-association memory task. Cortical layers were estimated on the basis of current source density profiles with histological verifications, and the interlaminar signal flow was determined with cross-correlation analysis between spike trains. During the cue period, canonical "feed-forward" signals flowed from granular to supragranular layers and from supragranular to infragranular layers. During the delay period, however, the signal flow reversed to the "feed-back" direction: from infragranular to supragranular layers. This reversal of signal flow highlights how the temporal cortex differentially recruits its laminar circuits for sensory and mnemonic processing.

Fatigue of LMFBR piping due to flow stratification

International Nuclear Information System (INIS)

Woodward, W.S.

1983-01-01

Flow stratification due to reverse flow was simulated in a 1/5-scale water model of a LMFBR primary pipe loop. The stratified flow was observed to have a dynamic interface region which oscillated in a wave pattern. The behavior of the interface was characterized in terms of location, local temperature fluctuation and duration for various reverse flow conditions. A structural assessment was performed to determine the effects of stratified flow on the fatigue life of the pipe. Both the static and dynamic aspects of flow stratification were examined. The dynamic interface produces thermal striping on the inside of the pipe wall which is shown to have the most deleterious effect on the pipe wall and produce significant fatigue damage relative to a static interface

Fatigue of LMFBR piping due to flow stratification

Energy Technology Data Exchange (ETDEWEB)

Woodward, W.S.

1983-01-01

Flow stratification due to reverse flow was simulated in a 1/5-scale water model of a LMFBR primary pipe loop. The stratified flow was observed to have a dynamic interface region which oscillated in a wave pattern. The behavior of the interface was characterized in terms of location, local temperature fluctuation and duration for various reverse flow conditions. A structural assessment was performed to determine the effects of stratified flow on the fatigue life of the pipe. Both the static and dynamic aspects of flow stratification were examined. The dynamic interface produces thermal striping on the inside of the pipe wall which is shown to have the most deleterious effect on the pipe wall and produce significant fatigue damage relative to a static interface.

Thyrotropin-releasing hormone (TRH) reverses hyperglycemia in rat

International Nuclear Information System (INIS)

Luo Luguang; Luo, John Z.Q.; Jackson, Ivor M.D.

2008-01-01

Hyperglycemia in thyrotropin-releasing hormone (TRH) null mice indicates that TRH is involved in the regulation of glucose homeostasis. Further, TRH levels in the pancreas peak during the stages of late embryonic and early neonatal β cell development. These observations are consistent in linking TRH to islet cell proliferation and differentiation. In this study, we examined the effect of TRH administration in damaged pancreatic rat (streptozotocin, STZ) to determine whether TRH could improve damaged pancreatic β cells function. We hypothesize that TRH is able to reverse STZ-induced hyperglycemia by increasing pancreatic islet insulin content, preventing apoptosis, and potentially induce islet regeneration. It was found that following intra-peritoneal (ip) injection, TRH (10 μg/kg body weight (bwt)) reverses STZ (65 mg/kg bwt)-induced hyperglycemia (TRH given 3 days after STZ injection). Increased circulating insulin levels and insulin content in extracted pancreas suggests that TRH reversed STZ-induced hyperglycemia through improving pancreatic islet β cell function. Further studies show a significantly lower level of apoptosis in islets treated with TRH as well as the presence of proliferation marker nestin and Brdu, suggesting that the TRH has the potential to prevent apoptosis and stimulate islet proliferation

Thrust reverser design studies for an over-the-wing STOL transport

Science.gov (United States)

Ammer, R. C.; Sowers, H. D.

1977-01-01

Aerodynamic and acoustics analytical studies were conducted to evaluate three thrust reverser designs for potential use on commercial over-the-wing STOL transports. The concepts were: (1) integral D nozzle/target reverser, (2) integral D nozzle/top arc cascade reverser, and (3) post exit target reverser integral with wing. Aerodynamic flowpaths and kinematic arrangements for each concept were established to provide a 50% thrust reversal capability. Analytical aircraft stopping distance/noise trade studies conducted concurrently with flow path design showed that these high efficiency reverser concepts are employed at substantially reduced power settings to meet noise goals of 100 PNdB on a 152.4 m sideline and still meet 609.6 m landing runway length requirements. From an overall installation standpoint, only the integral D nozzle/target reverser concept was found to penalize nacelle cruise performance; for this concept a larger nacelle diameter was required to match engine cycle effective area demand in reverse thrust.

Reverse flow injection spectrophotometric determination of thiram and nabam fungicides in natural water samples

International Nuclear Information System (INIS)

Asghar, M.; Yaqoob, M.; Nabi, A.

2014-01-01

A reverse flow injection (rFI) spectrophotometric method is reported for determination of thiram and nabam fungicides in natural water samples. The method is based on the reduction of iron(III) in the presence of thiram/nabam in acidic medium at 60 degree C and formation of iron(II)-ferricyanide complex was measured at 790 nm. The limits of detection (3s blank) were 0.01 and 0.05 micro g mL1 for thiram and nabam respectively with a sample throughput of 60 h1. Calibration graphs were linear over the range of 0.02 - 8.0 micro g mL1 (R2 = 0.9999, n = 8) and 0.1 - 30 micro g mL1 (R2 = 0.9982, n = 10) for thiram and nabam with relative standard deviations (RSDs; n = 3) in the range of 0.8 - 1.6% respectively. Experimental parameters and potential interferences were examined. Thiram and nabam were determined in natural water samples using solid-phase extraction (SPE) procedure and recoveries were in the range of 93+-3 - 105+-2% and 87+-4 - 102+-3% respectively. The results obtained were not significantly different compared with a HPLC method. (author)

Flow Diode and Method for Controlling Fluid Flow Origin of the Invention

Science.gov (United States)

Dyson, Rodger W (Inventor)

2015-01-01

A flow diode configured to permit fluid flow in a first direction while preventing fluid flow in a second direction opposite the first direction is disclosed. The flow diode prevents fluid flow without use of mechanical closures or moving parts. The flow diode utilizes a bypass flowline whereby all fluid flow in the second direction moves into the bypass flowline having a plurality of tortuous portions providing high fluidic resistance. The portions decrease in diameter such that debris in the fluid is trapped. As fluid only travels in one direction through the portions, the debris remains trapped in the portions.

Effect of load transients on SOFC operation—current reversal on loss of load

Science.gov (United States)

Gemmen, Randall S.; Johnson, Christopher D.

The dynamics of solid oxide fuel cell (SOFC) operation have been considered previously, but mainly through the use of one-dimensional codes applied to co-flow fuel cell systems. In this paper several geometries are considered, including cross-flow, co-flow, and counter-flow. The details of the model are provided, and the model is compared with some initial experimental data. For parameters typical of SOFC operation, a variety of transient cases are investigated, including representative load increase and decrease and system shutdown. Of particular note for large load decrease conditions (e.g., shutdown) is the occurrence of reverse current over significant portions of the cell, starting from the moment of load loss up to the point where equilibrated conditions again provide positive current. Consideration is given as to when such reverse current conditions might most significantly impact the reliability of the cell.

Simulation study of dynamo structure in reversed field pinch

International Nuclear Information System (INIS)

Nagata, A.; Sato, K.I.; Ashida, H.; Amano, T.

1992-10-01

The dynamo structure in the reversed field pinch (RFP) is studied through the nonlinear dynamics of single-helicity mode. Simulation is concentrated upon the physical structure of nonlinear interactions of the plasma flow and magnetic fluctuation. The result indicates that when the initial equilibrium profile is deformed by resistive diffusion, the radial flow is driven near the core of the plasma. As this flow forms a vortex structure and magnetic fluctuation grows radially, the dynamo electric field is spirally induced just inside the reversal surface and then the toroidal flux is increased. This dynamo electric field correlates to nonlinear evolution of the kinetic energy of m=1 mode, and the increase of the toroidal flux is originated in the growth process of the magnetic energy of this mode. Consequently, the RFP configuration can be sustained by the single-helicity evolution of m=1 mode alone, and the electric field induced by the interactions of the toroidal velocity and the radial magnetic field is the most dominant source on the dynamo action. (author)

Temporary targeted renal blood flow interruption using a reverse thermosensitive polymer to facilitate bloodless partial nephrectomy: a swine survival study.

Science.gov (United States)

Harty, Niall J; Laskey, Daniel H; Moinzadeh, Alireza; Flacke, Sebastian; Benn, James A; Villani, Rosanna; Kalra, Aarti; Libertino, John A; Madras, Peter N

2012-09-01

What's known on the subject? and What does the study add? Lumagel™ is a reverse thermosensitive polymer (RTP) that has previously been described in the literature as providing temporary vascular occlusion to allow for bloodless partial nephrectomy (PN) while maintaining blood flow to the untargeted portion of the kidney. At body temperature, Lumagel™ has the consistency of a viscous gel but upon cooling rapidly converts to a liquid state and does not reconstitute thereafter. This property has allowed for it to be used in situations requiring temporary vascular occlusion. Previous experience with similar RTPs in coronary arteries proved successful, with no detectable adverse events. We have previously described our technique for temporary vascular occlusion of the main renal artery, as well as segmental and sub-segmental renal branches, to allow for bloodless PN in either an open or minimally invasive approach. These experiments were performed in the acute setting. This study is a two-armed survival trial to assess whether this RTP is as safe as hilar clamping for bloodless PN. Surviving animals showed normal growth after using the RTP, absence of toxicity, no organ dysfunction, and no pathological changes attributable to the RTP. We conclude that Lumagel™ is as safe as conventional PN with hilar clamping, while adding the advantage of uninterrupted perfusion during renal resection. To examine whether randomly selected regions of the kidney could undergo temporary flow interruption with a reverse thermosensitive polymer (RTP), Lumagel™ (Pluromed, Inc., Woburn, MA, USA), followed by partial nephrectomy (PN), without adding risks beyond those encountered in the same procedure with the use of hilar clamping. A two-armed (RTP vs hilar clamp), 6-week swine survival study was performed. Four swine underwent PN using hilar clamps, while six underwent PN with flow interruption using the RTP. The RTP, administered angiographically, was used for intraluminal occlusion

Physicochemical attack against solid tumors based on the reversal of direction of entropy flow: an attempt to introduce thermodynamics in anticancer therapy

Directory of Open Access Journals (Sweden)

Lv Xiaogui

2006-11-01

tissues, the rate of entropy production of normal cells may exceed that of cancerous cells. Consequently, the application of external energy to the body can reverse the direction of the entropy current. The harmful effect brought about by the entropy flow from cancerous to healthy tissue can be blocked by the reversed direction of entropy current from the irradiated normal tissue around the tumor.

Harmonic analysis of the stability of reverse routing in channels

Directory of Open Access Journals (Sweden)

2007-01-01

Full Text Available Normal downstream routing of a flood flow is a highly stable process for Froude numbers less than 1 and hence the results are reliable. In contrast, reverse routing in an upstream direction, which may be required for flow control, is potentially unstable. This paper reports the results of a study of the practical limits on channel lengths for reverse routing. Harmonic analysis is applied to the full non-linear solution of the St. Venant equations for three different wave patterns and two different wave periods, for a particular channel with a Froude number of 0.5. Reverse routing can be done for prismatic channels longer than 100 km. For long periods (>10 hours the shape of the upstream hydrograph is recovered well. However, when the wave period is short (<1 hour, the high frequency components of the upstream hydrograph and, thus, its shape, are not recovered. These limits are influenced by the channel morphology and shape of the wave. Further work is needed to determine how these factors interact.

Improvement of the MSG code for the MONJU evaporators. Additional function of reverse flow calculation on water/steam model and animation for post processing

International Nuclear Information System (INIS)

Toda, Shin-ichi; Yoshikawa, Shinji; Oketani, Kazuhiro

2003-05-01

The improved version of the MSG code (Multi-dimensional Thermal-hydraulic Analysis Code for Steam Generators) has been released. It has been carried out to improve based on the original version in order to calculate reverse flow on water/steam side, and to animate the post-processing data. To calculate reverse flow locally, modification to set pressure at each divided node point of water/steam region in the helical-coil heat transfer tubes has been carried out. And the matrix solver has been also improved to treat a problem within practical calculation time against increasing the pressure points. In this case pressure and enthalpy have to be calculated simultaneously, however, it was found out that using the block-Jacobean method make a diagonal-dominant matrix, and solve the matrix efficiently with a relaxation method. As the result of calculations of a steady-state condition and a transient of SG blow down with manual trip operation, the improvement on calculation function of the MSG code was confirmed. And an animation function of temperature contour in the sodium shell side as a post processing has been added. Since the animation is very effective to understand thermal-hydraulic behavior on the sodium shell side of the SG, especially in case of transient condition, the analysis and evaluation of the calculation results will be enabled to be more quickly and effectively. (author)

MMOSS-I: a CANDU multiple-channel thermosyphoning flow stability model

Energy Technology Data Exchange (ETDEWEB)

Gulshani, P [Atomic Energy of Canada Ltd., Mississauga, ON (Canada); Huynh, H [Hydro-Quebec, Montreal, PQ (Canada)

1996-12-31

This paper presents a multiple-channel flow stability model, dubbed MMOSS, developed to predict the conditions for the onset of flow oscillations in a CANDU-type multiple-channel heat transport system under thermosyphoning conditions. The model generalizes that developed previously to account for the effects of any channel flow reversal. Two-phase thermosyphoning conditions are predicted by thermalhydraulic codes for some postulated accident scenarios in CANDU. Two-phase thermosyphoning experiments in the multiple-channel RD-14M facility have indicated that pass-to-pass out-of-phase oscillations in the loop conditions caused the flow in some of the heated channels to undergo sustained reversal in direction. This channel flow reversal had significant effects on the channel and loop conditions. It is, therefore, important to understand the nature of the oscillations and be able to predict the conditions for the onset of the oscillations or for stable flow in RD-14M and the reactor. For stable flow conditions, oscillation-induced channel flow reversal is not expected. MMOSS was developed for a figure-of-eight system with any number of channels. The system characteristic equation was derived from a linearization of the conservation equations. In this paper, the MMOSS characteristic equation is solved for a system of N identical channel assemblies. The resulting model is called MMOSS-I. This simplification provides valuable physical insight and reasonably accurate results. MMOSS-I and a previously-developed steady-state model THERMOSYPHON are used to predict thermosyphoning flow stability maps for RD-14M and the Gentilly 2 reactor. (author). 11 refs., 7 figs.

Experimental Study of Unsteady Flow Separation in a Laminar Boundary Layer

Science.gov (United States)

Bonacci, Andrew; Lang, Amy; Wahidi, Redha; Santos, Leonardo

2017-11-01

Flow separation, caused by an adverse pressure gradient, is a major problem in many applications. Reversing flow near the wall is the first sign of incipient separation and can bristle shark scales which may be linked to a passive, flow actuated separation control mechanism. An investigation of how this backflow forms and how it interacts with shark skin is of interest due to the fact that this could be used as a bioinspired means of initiating flow control. A water tunnel experiment aims to study unsteady separation with a focus on the reversing flow development near the wall within a flat plate laminar boundary layer (Re on order of 105) as an increasing adverse pressure gradient is induced by a rotating cylinder. Unsteady reversing flow development is documented using DPIV. Funding was provided by the National Science Foundation under the Research Experience for Undergraduates (REU) program (EEC 1659710) and the Army Research Office.

Electrical power from sea and river water by reverse electrodialysis: a first step from the laboratory to a real power plant.

Science.gov (United States)

Veerman, Joost; Saakes, Michel; Metz, Sybrand J; Harmsen, G Jan

2010-12-01

Electricity can be produced directly with reverse electrodialysis (RED) from the reversible mixing of two solutions of different salinity, for example, sea and river water. The literature published so far on RED was based on experiments with relatively small stacks with cell dimensions less than 10 × 10 cm(2). For the implementation of the RED technique, it is necessary to know the challenges associated with a larger system. In the present study we show the performance of a scaled-up RED stack, equipped with 50 cells, each measuring 25 × 75 cm(2). A single cell consists of an AEM (anion exchange membrane) and a CEM (cation exchange membrane) and therefore, the total active membrane area in the stack is 18.75 m(2). This is the largest dimension of a reverse electrodialysis stack published so far. By comparing the performance of this stack with a small stack (10 × 10 cm(2), 50 cells) it was found that the key performance parameter to maximal power density is the hydrodynamic design of the stack. The power densities of the different stacks depend on the residence time of the fluids in the stack. For the large stack this was negatively affected by the increased hydrodynamic losses due to the longer flow path. It was also found that the large stack generated more power when the sea and river water were flowing in co-current operation. Co-current flow has other advantages, the local pressure differences between sea and river water compartments are low, hence preventing leakage around the internal manifolds and through pinholes in the membranes. Low pressure differences also enable the use of very thin membranes (with low electrical resistance) as well as very open spacers (with low hydrodynamic losses) in the future. Moreover, we showed that the use of segmented electrodes increase the power output by 11%.

Method of preventing sodium from flowing when pipes of a fast breeder reactor are injured

International Nuclear Information System (INIS)

Nakai, Yasushi; Yamagishi, Yoshiaki; Koga, Tomonari.

1975-01-01

Object: To inject high pressure sodium into an inlet nozzle portion when fluid pressure in the inlet nozzle portion of a core cooling pipe on the inlet side is in an abnormal condition, to thereby quickly and positively prevent the flow of sodium in a high pressure chamber in a reactor vessel, when pipes are injured. Structure: When the core cooling pipe on the inlet side is injured and as a consequence the pressure gage detects an abnormal condition of fluid pressure in the inlet nozzle, the valve is opened to allow high pressure sodium to inject into the inlet nozzle through a high pressure sodium supply pipe, thereby blocking a back-flow of sodium in the high pressure chamber into the core cooling pipe. (Kamimura, M.)

Closing the Loop : Reverse supply chain management andproduct return processes in electronics retailing

OpenAIRE

Gorskova, Julija; Ortega, Edrion

2012-01-01

Abstract Problem There is a gap in the knowledge concerning reverse product flows due to a lack of research and empirical data in the field of reverse supply chain management in general. Furthermore, more research is needed to investigate the factors influencing the decision making process regarding the right reverse supply chain recovery option choice for companies in order to close the supply chain loop. Processing product returns has become a critical activity for organisations as the volu...

Inorganic fouling mitigation by salinity cycling in batch reverse osmosis

OpenAIRE

Maswadeh, Laith A.; Warsinger, David Elan Martin; Tow, Emily W.; Connors, Grace B.; Swaminathan, Jaichander; Lienhard, John H

2018-01-01

Enhanced fouling resistance has been observed in recent variants of reverse osmosis (RO) desalination which use time-varying batch or semi-batch processes, such as closed-circuit RO (CCRO) and pulse flow RO (PFRO). However, the mechanisms of batch processes' fouling resistance are not well-understood, and models have not been developed for prediction of their fouling performance. Here, a framework for predicting reverse osmosis fouling is developed by comparing the fluid residence time in bat...

Integrating reverse logistics and eco-design: a proposal for a new framework

Directory of Open Access Journals (Sweden)

Felipe Kich Gontijo

2014-07-01

Full Text Available The concepts of Reverse Logistics and Eco-design are discussed in this paper, suggesting that these applications are often treated differently, thus not being able to achieve a higher performance in relation to environmental sustainability. The reason is most reverse logistics applications have a repairer action, since their waste generation is not planned along with product design. The proposal shows how the two concepts can work together, describing the time of each application.Unfolding the two concepts into reverse channels concerning logistics and life cycle analysis of the product as per eco-design, an application model has been developed, promoting integration between the two practices, so that the reverse supply chain is planned along with the product.The result is the development of a model for implementing reverse logistics integrating eco-design, thus optimizing the reverse flow of waste.

Convection flow study within a horizontal fluid layer under the action of gas flow

Directory of Open Access Journals (Sweden)

Kreta Aleksei

2016-01-01

Full Text Available Experimental investigation of convective processes within horizontal evaporating liquid layer under shear–stress of gas flow is presented. It is found the structures of the convection, which move in opposite direction relative to each other. First convective structure moves in reverse direction with the flow of gas, and the second convective structure moves towards the gas flow. Convection flow within the liquid layer is registered with help of PIV technique. Average evaporation flow rate of Ethanol liquid layer under Air gas flow is measured. Influence of the gas velocity, at a constant temperature of 20 °C, on the evaporation flow rate has been studied.

Bayesian uncertainty quantification for flows in heterogeneous porous media using reversible jump Markov chain Monte Carlo methods

KAUST Repository

Mondal, A.

2010-03-01

In this paper, we study the uncertainty quantification in inverse problems for flows in heterogeneous porous media. Reversible jump Markov chain Monte Carlo algorithms (MCMC) are used for hierarchical modeling of channelized permeability fields. Within each channel, the permeability is assumed to have a lognormal distribution. Uncertainty quantification in history matching is carried out hierarchically by constructing geologic facies boundaries as well as permeability fields within each facies using dynamic data such as production data. The search with Metropolis-Hastings algorithm results in very low acceptance rate, and consequently, the computations are CPU demanding. To speed-up the computations, we use a two-stage MCMC that utilizes upscaled models to screen the proposals. In our numerical results, we assume that the channels intersect the wells and the intersection locations are known. Our results show that the proposed algorithms are capable of capturing the channel boundaries and describe the permeability variations within the channels using dynamic production history at the wells. © 2009 Elsevier Ltd. All rights reserved.

A Singular Perturbation Problem for Steady State Conversion of Methane Oxidation in Reverse Flow Reactor

Directory of Open Access Journals (Sweden)

Aang Nuryaman

2012-11-01

Full Text Available The governing equations describing the methane oxidation process in reverse flow reactor are given by a set of convective-diffusion equations with a nonlinear reaction term, where temperature and methane conversion are dependent variables. In this study, the process is assumed to be one-dimensional pseudo homogeneous model and takes place with a certain reaction rate in which the whole process of reactor is still workable. Thus, the reaction rate can proceed at a fixed temperature. Under this condition, we restrict ourselves to solve the equations for the conversion only. From the available data, it turns out that the ratio of the diffusion term to the reaction term is small. Hence, this ratio is considered as small parameter in our model and this leads to a singular perturbation problem. In the vicinity of small parameter in front of higher order term, the numerical difficulties will be found. Here, we present an analytical solution by means of matched asymptotic expansions. Result shows that, up to and including the first order of approximation, the solution is in agreement with the exact and numerical solutions of the boundary value problem.

Radial Flow Effects On A Retreating Rotor Blade

Science.gov (United States)

2014-05-01

birds , marine life and even insect wings. In some cases such as helicopters, wind turbines and compres- sors, dynamic stall becomes the primary...on dynamic stall and reverse flow as applied to a helicopter rotor in forward flight and a wind turbine operating at a yaw angle. While great...occurring on a retreating blade with a focus on dynamic stall and reverse flow as applied to a helicopter rotor in forward flight and a wind turbine

Plasma flow in the DIII-D divertor

International Nuclear Information System (INIS)

Boedo, J.A.; Porter, G.D.; Schaffer, M.J.

1998-07-01

Indications that flows in the divertor can exhibit complex behavior have been obtained from 2-D modeling but so far remain mostly unconfirmed by experiment. An important feature of flow physics is that of flow reversal. Flow reversal has been predicted analytically and it is expected when the ionization source arising from neutral or impurity ionization in the divertor region is large, creating a high pressure zone. Plasma flows arise to equilibrate the pressure. A radiative divertor regime has been proposed in order to reduce the heat and particle fluxes to the divertor target plates. In this regime, the energy and momentum of the plasma are dissipated into neutral gas introduced in the divertor region, cooling the plasma by collisional, radiative and other atomic processes so that the plasma becomes detached from the target plates. These regimes have been the subject of extensive studies in DIII-D to evaluate their energy and particle transport properties, but only recently it has been proposed that the energy transport over large regions of the divertor must be dominated by convection instead of conduction. It is therefore important to understand the role of the plasma conditions and geometry on determining the region of convection-dominated plasma in order to properly control the heat and particle fluxes to the target plates and hence, divertor performance. The authors have observed complex structures in the deuterium ion flows in the DIII-D divertor. Features observed include reverse flow, convective flow over a large volume of the divertor and stagnant flow. They have measured large gradients in the plasma potential across the separatrix in the divertor and determined that these gradients induce poloidal flows that can potentially affect the particle balance in the divertor

A model for 'reverse innovation' in health care.

Science.gov (United States)

Depasse, Jacqueline W; Lee, Patrick T

2013-08-30

'Reverse innovation,' a principle well established in the business world, describes the flow of ideas from emerging to more developed economies. There is strong and growing interest in applying this concept to health care, yet there is currently no framework for describing the stages of reverse innovation or identifying opportunities to accelerate the development process. This paper combines the business concept of reverse innovation with diffusion of innovation theory to propose a model for reverse innovation as a way to innovate in health care. Our model includes the following steps: (1) identifying a problem common to lower- and higher-income countries; (2) innovation and spread in the low-income country (LIC); (3) crossover to the higher-income country (HIC); and (4) innovation and spread in the HIC. The crucial populations in this pathway, drawing from diffusion of innovation theory, are LIC innovators, LIC early adopters, and HIC innovators. We illustrate the model with three examples of current reverse innovations. We then propose four sets of specific actions that forward-looking policymakers, entrepreneurs, health system leaders, and researchers may take to accelerate the movement of promising solutions through the reverse innovation pipeline: (1) identify high-priority problems shared by HICs and LICs; (2) create slack for change, especially for LIC innovators, LIC early adopters, and HIC innovators; (3) create spannable social distances between LIC early adopters and HIC innovators; and (4) measure reverse innovation activity globally.

Application of Shark Skin Flow Control Techniques to Airflow

Science.gov (United States)

Morris, Jackson Alexander

Due to millions of years of evolution, sharks have evolved to become quick and efficient ocean apex predators. Shark skin is made up of millions of microscopic scales, or denticles, that are approximately 0.2 mm in size. Scales located on the shark's body where separation control is paramount (such as behind the gills or the trailing edge of the pectoral fin) are capable of bristling. These scales are hypothesized to act as a flow control mechanism capable of being passively actuated by reversed flow. It is believed that shark scales are strategically sized to interact with the lower 5% of a boundary layer, where reversed flow occurs at the onset of boundary layer separation. Previous research has shown shark skin to be capable of controlling separation in water. This thesis aims to investigate the same passive flow control techniques in air. To investigate this phenomenon, several sets of microflaps were designed and manufactured with a 3D printer. The microflaps were designed in both 2D (rectangular) and 3D (mirroring shark scale geometry) variants. These microflaps were placed in a low-speed wind tunnel in the lower 5% of the boundary layer. Solid fences and a flat plate diffuser with suction were placed in the tunnel to create different separated flow regions. A hot film probe was used to measure velocity magnitude in the streamwise plane of the separated regions. The results showed that low-speed airflow is capable of bristling objects in the boundary layer. When placed in a region of reverse flow, the microflaps were passively actuated. Microflaps fluctuated between bristled and flat states in reverse flow regions located close to the reattachment zone.

Prevention and reversal of social stress-escalated cocaine self-administration in mice by intra-VTA CRFR1 antagonism.

Science.gov (United States)

Han, Xiao; DeBold, Joseph F; Miczek, Klaus A

2017-09-01

A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How repeated stress modulates CRF release in the ventral tegmental area (VTA) and the roles of CRF receptors during different phases of stress-induced cocaine self-administration remain to be defined. The current study examines the roles of CRF and CRF receptor 1 (CRFR1) in escalated intravenous cocaine self-administration after exposure to social defeat stress in mice. First, CRFR1 antagonist (CP 376,395, 15 mg/kg, i.p.) given 30 min prior to each social defeat episode prevented later escalated cocaine self-administration. When CP 376,395 (5 and 15 mg/kg, i.p.) was administered 10 days after the last episode of social stress, the escalation of cocaine intake was dose-dependently reversed. Moreover, socially defeated mice showed increased CRF release in the VTA compared to controls. To further explore the role of CRFR1, CP 376,395 (0.5 and 1 μg/0.2 μl) was infused directly into the VTA before the cocaine self-administration session. Intra-VTA antagonism of CRFR1 was sufficient to reverse social defeat stress-escalated cocaine self-administration. These findings suggest that CRF and CRFR1 exert multiple roles in the response to social stress that are relevant to escalated cocaine self-administration.

The significance of reverse flow in ductus venosus between sixteen and twenty weeks’ gestation

Directory of Open Access Journals (Sweden)

Gökhan Karakoç

2017-03-01

Full Text Available Objective: To evaluate the correlation between reversed a-wave in ductus venosus at 16-20 weeks’ gestation and trisomy 21 and adverse perinatal outcomes. Materials and Methods: Our study included 174 pregnant women who were under follow-up at a tertiary center between May and September 2010. Ductus venosus Doppler (DVD measurements were obtained throughout the 6-month period from women who underwent amniocentesis procedures due to increased risk for trisomy 21 in terms of first or second trimester screening test results. These women were followed up for enrollment of subsequent data about perinatal outcomes. Results: In 13 of 174 cases, Doppler studies indicated a reversed a-wave in the ductus venosus. Of these fetuses, 3 were diagnosed as having trisomy 21 after amniocentesis, which related to 60% (3 of 5 fetuses of all fetuses with trisomy 21. The pregnant women with reversed a-wave in DVD also had an increased rate of preeclampsia (15% and gestational diabetes mellitus (GDM (23% in late pregnancy. Conclusion: Reversed a-wave in ductus venosus between 16-20 weeks’ gestation is associated with increased risk of trisomy 21, preeclampsia, and GDM. If further prospective studies confirm its utility, DVD interrogation for trisomy 21 may be extended until 20 weeks’ gestation.

Investigation of the specific mass flow rate distribution in pipes supplied with a pulsating flow

Energy Technology Data Exchange (ETDEWEB)

Olczyk, Aleksander [Institute of Turbomachinery, Technical University of Lodz, Wolczanska 219/223, 90-924 Lodz (Poland)], E-mail: aolczyk@p.lodz.pl

2009-08-15

A pulsating flow is typical of inlet and exhaust pipes of internal combustion engines and piston compressors. Unsteady flow phenomena are especially important in the case of turbocharged engines, because dynamic effects occurring in the exhaust pipe can affect turbine operation conditions and performance. One of the basic parameters describing the unsteady flow is a transient mass flow rate related to the instantaneous flow velocity, which is usually measured by means of hot-wire anemometers. For the flowing gas, it is more appropriate to analyze the specific mass flow rate {phi}{sub m} = {rho}v, which takes into account also variations in the gas density. In order to minimize the volume occupied by measuring devices in the control section, special double-wire sensors for the specific mass flow rate (CTA) and temperature (CCT) measurement were applied. The article describes procedures of their calibration and measurement. Different forms of calibration curves are analyzed as well in order to match the approximation function to calibration points. Special attention is paid to dynamic phenomena related to the resonance occurring in a pipe for characteristic frequencies depending on the pipe length. One of these phenomena is a reverse flow, which makes it difficult to interpret properly the recorded CTA signal. Procedures of signal correction are described in detail. To verify the measurements, a flow field investigation was carried out by displacing probes radially and determining the profiles of the specific mass flow rate under the conditions of a steady and pulsating flow. The presence and general features of a reverse flow, which was identified experimentally, were confirmed by 1-D unsteady flow calculations.

Investigation of the specific mass flow rate distribution in pipes supplied with a pulsating flow

International Nuclear Information System (INIS)

Olczyk, Aleksander

2009-01-01

A pulsating flow is typical of inlet and exhaust pipes of internal combustion engines and piston compressors. Unsteady flow phenomena are especially important in the case of turbocharged engines, because dynamic effects occurring in the exhaust pipe can affect turbine operation conditions and performance. One of the basic parameters describing the unsteady flow is a transient mass flow rate related to the instantaneous flow velocity, which is usually measured by means of hot-wire anemometers. For the flowing gas, it is more appropriate to analyze the specific mass flow rate φ m = ρv, which takes into account also variations in the gas density. In order to minimize the volume occupied by measuring devices in the control section, special double-wire sensors for the specific mass flow rate (CTA) and temperature (CCT) measurement were applied. The article describes procedures of their calibration and measurement. Different forms of calibration curves are analyzed as well in order to match the approximation function to calibration points. Special attention is paid to dynamic phenomena related to the resonance occurring in a pipe for characteristic frequencies depending on the pipe length. One of these phenomena is a reverse flow, which makes it difficult to interpret properly the recorded CTA signal. Procedures of signal correction are described in detail. To verify the measurements, a flow field investigation was carried out by displacing probes radially and determining the profiles of the specific mass flow rate under the conditions of a steady and pulsating flow. The presence and general features of a reverse flow, which was identified experimentally, were confirmed by 1-D unsteady flow calculations.

In-Line Oil-Water Separation in Swirling Flow (USB stick)

NARCIS (Netherlands)

Slot, J.J.; van Campen, L.J.A.M.; Hoeijmakers, Hendrik Willem Marie; Mudde, R.F.; Johansen, S.T.

2011-01-01

An in-line oil-water separator has been designed and is investigated for single- and two-phase flow. Numerical single-phase flow results show an annular reversed flow region. This flow pattern agrees qualitatively with results from measurements. In the two-phase flow simulations two different drag

Monoamines stimulate sex reversal in the saddleback wrasse.

Science.gov (United States)

Larson, Earl T; Norris, David O; Gordon Grau, E; Summers, Cliff H

2003-02-15

Monoamine neurotransmitters (norepinephrine, dopamine, and serotonin) play an important role in reproduction and sexual behavior throughout the vertebrates. They are the first endogenous chemical signals in the regulation of the hypothalamo-pituitary-gonadal (HPG) axis. In teleosts with behavioral sex determination, much is known about behavioral cues that induce sex reversal. The cues are social, processed via the visual system and depend on the ratio of females to males in the population. The mechanisms by which these external behavioral cues are converted to an internal chemical regulatory process are largely unknown. The protogynous Hawaiian saddleback wrasse, Thalassoma duperrey, was used to investigate the biological pathway mediating the conversion of a social cue into neuroendocrine events regulating sex reversal. Because monoamines play an important role in the regulation of the HPG axis, they were selected as likely candidates for such a conversion. To determine if monoamines could affect sex reversal, drugs affecting monoamines were used in an attempt to either induce sex reversal under non-permissive conditions, or prevent sex reversal under permissive conditions. Increasing norepinephrine or blocking dopamine or serotonin lead to sex reversal in experimental animals under non-permissive conditions. Increasing serotonin blocked sex reversal under permissive conditions, while blocking dopamine or norepinephrine retarded the process. The results presented here demonstrate that monoamines contribute significantly to the control sex reversal. Norepinephrine stimulates initiation and completion of gonadal sex of reversal as well as color change perhaps directly via its effects on the HPG axis. Dopamine exercises inhibitory action on the initiation of sex reversal while 5-HT inhibits both initiation and completion of sex reversal. The serotonergic system appears to be an integral part of the pathway mediating the conversion of a social cue into a

Regulation of biliary cholesterol secretion and reverse cholesterol transport

NARCIS (Netherlands)

Dikkers, Arne

2016-01-01

According to the World Health Organization the number one cause of death throughout the world is cardiovascular disease. Therefore, there is an urgent need for new therapeutic strategies to prevent and treat cardiovascular disease. One possible way is to target the HDL-driven reverse cholesterol

Developing weighted criteria to evaluate lean reverse logistics through analytical network process

Science.gov (United States)

Zagloel, Teuku Yuri M.; Hakim, Inaki Maulida; Krisnawardhani, Rike Adyartie

2017-11-01

Reverse logistics is a part of supply chain that bring materials from consumers back to manufacturer in order to gain added value or do a proper disposal. Nowadays, most companies are still facing several problems on reverse logistics implementation which leads to high waste along reverse logistics processes. In order to overcome this problem, Madsen [Framework for Reverse Lean Logistics to Enable Green Manufacturing, Eco Design 2009: 6th International Symposium on Environmentally Conscious Design and Inverse Manufacturing, Sapporo, 2009] has developed a lean reverse logistics framework as a step to eliminate waste by implementing lean on reverse logistics. However, the resulted framework sets aside criteria used to evaluate its performance. This research aims to determine weighted criteria that can be used as a base on reverse logistics evaluation by considering lean principles. The resulted criteria will ensure reverse logistics are kept off from waste, thus implemented efficiently. Analytical Network Process (ANP) is used in this research to determine the weighted criteria. The result shows that criteria used for evaluation lean reverse logistics are Innovation and Learning (35%), Economic (30%), Process Flow Management (14%), Customer Relationship Management (13%), Environment (6%), and Social (2%).

Classical transport in field reversed mirrors: reactor implications

International Nuclear Information System (INIS)

Auerbach, S.P.; Condit, W.C.

1980-01-01

Assuming that the field-reversed mirror (or the closely related spheromak) turns out to be stable, the next crucial issue is transport of particles and heat. Of particular concern is the field null on axis (the X-point), which at first glance seems to allow particles to flow out unhindered. We have evaluated the classical diffusion coefficients for particles and heat in field-reversed mirrors, with particular reference to a class of Hill's vortex models. Two fairly surprising results emerge from this study. First, the diffusion-driven flow of particles and heat is finite at the X-points. This may be traced to the geometrical constraint that the current (and hence the ion-electron drag force, which causes cross-field transport) must vanish on axis. This conclusion holds for any transport model. Second, the classical diffusion coefficient D(psi), which governs both particle and heat flux, is finite on the separatrix. Indeed, in a wide class of Hill's vortex equilibria (spherical, oblate, or prolate) D(psi) is essentially independent of psi (except for the usual factor of n

Hydrophilic, bactericidal nanoheater-enabled reverse osmosis membranes to improve fouling resistance.

Science.gov (United States)

Ray, Jessica R; Tadepalli, Sirimuvva; Nergiz, Saide Z; Liu, Keng-Ku; You, Le; Tang, Yinjie; Singamaneni, Srikanth; Jun, Young-Shin

2015-06-03

Polyamide (PA) semipermeable membranes typically used for reverse osmosis water treatment processes are prone to fouling, which reduces the amount and quality of water produced. By synergistically coupling the photothermal and bactericidal properties of graphene oxide (GO) nanosheets, gold nanostars (AuNS), and hydrophilic polyethylene glycol (PEG) on PA reverse osmosis membrane surfaces, we have dramatically improved fouling resistance of these membranes. Batch fouling experiments from three classes of fouling are presented: mineral scaling (CaCO3 and CaSO4), organic fouling (humic acid), and biofouling (Escherichia coli). Systematic analyses and a variety of complementary techniques were used to elucidate fouling resistance mechanisms from each layer of modification on the membrane surface. Both mineral scaling and organic fouling were significantly reduced in PA-GO-AuNS-PEG membranes compared to other membranes. The PA-GO-AuNS-PEG membrane was also effective in killing all near-surface bacteria compared to PA membranes. In the PA-GO-AuNS-PEG membrane, the GO nanosheets act as templates for in situ AuNS growth, which then facilitated localized heating upon irradiation by an 808 nm laser inactivating bacteria on the membrane surface. Furthermore, AuNS in the membrane assisted PEG in preventing mineral scaling on the membrane surface. In flow-through flux and foulant rejection tests, PA-GO-AuNS-PEG membranes performed better than PA membranes in the presence of CaSO4 and humic acid model foulants. Therefore, the newly suggested membrane surface modifications will not only reduce fouling from RO feeds, but can improve overall membrane performance. Our innovative membrane design reported in this study can significantly extend the lifetime and water treatment efficacy of reverse osmosis membranes to alleviate escalating global water shortage from rising energy demands.

In situ study on reverse polarity effect in Cu/Sn–9Zn/Ni interconnect undergoing liquid–solid electromigration

Energy Technology Data Exchange (ETDEWEB)

Huang, M.L., E-mail: huang@dlut.edu.cn; Zhang, Z.J.; Zhao, N.; Yang, F.

2015-01-15

Highlights: • Abnormal reverse polarity effect in Cu/Sn–9Zn/Ni interconnect during L–S EM was observed. • The reverse polarity effect was resulted from directional diffusion of Zn to cathode. • Positive effective charge number is responsible for directional diffusion of Zn atom. • The effective charge number value of Zn was calculated to be +0.63 based on a model. • This effect is beneficial to EM reliability of micro-bump solder interconnect. - Abstract: Synchrotron radiation real-time imaging technology was used to in situ study the interfacial reactions in Cu/Sn–9Zn/Ni solder interconnects undergoing liquid–solid electromigration (L–S EM). The reverse polarity effect, evidenced by the continuous growth of intermetallic compound (IMC) layer at the cathode and the thinning of the IMC layer at the anode, was resulted from the abnormal directional migration of Zn atoms toward the cathode in electric field. This abnormal migration behavior was induced by the positive effective charge number (Z{sup ∗}) of Zn atoms, which was calculated to be +0.63 based on the Cu fluxes and the consumption kinetics of the anode Cu. Irrespective of the flowing direction of electrons, the consumption of Cu film was obvious while that of Ni film was limited. The dissolution of anode Cu followed a linear relationship with time while that of cathode Cu followed a parabolic relationship with time. It is more damaging with electrons flowing from the Ni to the Cu than that from the Cu to the Ni. The simulated Zn concentration distributions gave an explanation on the relationship between abnormal migration behavior of Zn atoms and the dissolution of Cu film under electron wind force. The abnormal directional migration of Zn atoms toward the cathode prevented the dissolution of cathode substrate, which is beneficial to improve the EM reliability of micro-bump solder interconnects.

Critical evaluation of reverse engineering tool Imagix 4D!

Science.gov (United States)

Yadav, Rashmi; Patel, Ravindra; Kothari, Abhay

2016-01-01

The comprehension of legacy codes is difficult to understand. Various commercial reengineering tools are available that have unique working styles, and are equipped with their inherent capabilities and shortcomings. The focus of the available tools is in visualizing static behavior not the dynamic one. Therefore, it is difficult for people who work in software product maintenance, code understanding reengineering/reverse engineering. Consequently, the need for a comprehensive reengineering/reverse engineering tool arises. We found the usage of Imagix 4D to be good as it generates the maximum pictorial representations in the form of flow charts, flow graphs, class diagrams, metrics and, to a partial extent, dynamic visualizations. We evaluated Imagix 4D with the help of a case study involving a few samples of source code. The behavior of the tool was analyzed on multiple small codes and a large code gcc C parser. Large code evaluation was performed to uncover dead code, unstructured code, and the effect of not including required files at preprocessing level. The utility of Imagix 4D to prepare decision density and complexity metrics for a large code was found to be useful in getting to know how much reengineering is required. At the outset, Imagix 4D offered limitations in dynamic visualizations, flow chart separation (large code) and parsing loops. The outcome of evaluation will eventually help in upgrading Imagix 4D and posed a need of full featured tools in the area of software reengineering/reverse engineering. It will also help the research community, especially those who are interested in the realm of software reengineering tool building.

Reverse Algols

Science.gov (United States)

Leung, K. C.

1989-01-01

Reverse Algols, binary systems with a semidetached configuration in which the more massive component is in contact with the critical equipotential surface, are examined. Observational evidence for reverse Algols is presented and the parameters of seven reverse Algols are listed. The evolution of Algols and reverse Algols is discussed. It is suggested that, because reverse Algols represent the premass-reversal semidetached phase of close binary evolution, the evolutionary time scale between regular and reverse Algols is the ratio of the number of confirmed systems of these two Algol types.

Movable shark scales act as a passive dynamic micro-roughness to control flow separation

International Nuclear Information System (INIS)

Lang, Amy W; Bradshaw, Michael T; Smith, Jonathon A; Wheelus, Jennifer N; Motta, Philip J; Habegger, Maria L; Hueter, Robert E

2014-01-01

Shark scales on fast-swimming sharks have been shown to be movable to angles in excess of 50°, and we hypothesize that this characteristic gives this shark skin a preferred flow direction. During the onset of separation, flow reversal is initiated close to the surface. However, the movable scales would be actuated by the reversed flow thereby causing a greater resistance to any further flow reversal and this mechanism would disrupt the process leading to eventual flow separation. Here we report for the first time experimental evidence of the separation control capability of real shark skin through water tunnel testing. Using skin samples from a shortfin mako Isurus oxyrinchus, we tested a pectoral fin and flank skin attached to a NACA 4412 hydrofoil and separation control was observed in the presence of movable shark scales under certain conditions in both cases. We hypothesize that the scales provide a passive, flow-actuated mechanism acting as a dynamic micro-roughness to control flow separation. (paper)

Electrochemical transformation of trichloroethylene in aqueous solution by electrode polarity reversal.

Science.gov (United States)

Rajic, Ljiljana; Fallahpour, Noushin; Yuan, Songhu; Alshawabkeh, Akram N

2014-12-15

Electrode polarity reversal is evaluated for electrochemical transformation of trichloroethylene (TCE) in aqueous solution using flow-through reactors with mixed metal oxide electrodes and Pd catalyst. The study tests the hypothesis that optimizing electrode polarity reversal will generate H2O2 in Pd presence in the system. The effect of polarity reversal frequency, duration of the polarity reversal intervals, current intensity and TCE concentration on TCE removal rate and removal mechanism were evaluated. TCE removal efficiencies under 6 cycles h(-1) were similar in the presence of Pd catalyst (50.3%) and without Pd catalyst (49.8%), indicating that Pd has limited impact on TCE degradation under these conditions. The overall removal efficacies after 60 min treatment under polarity reversal frequencies of 6, 10, 15, 30 and 90 cycles h(-1) were 50.3%, 56.3%, 69.3%, 34.7% and 23.4%, respectively. Increasing the frequency of polarity reversal increases TCE removal as long as sufficient charge is produced during each cycle for the reaction at the electrode. Electrode polarity reversal shifts oxidation/reduction and reduction/oxidation sequences in the system. The optimized polarity reversal frequency (15 cycles h(-1) at 60 mA) enables two reaction zones formation where reduction/oxidation occurs at each electrode surface. Published by Elsevier Ltd.

An automated approach for generating and checking control logic for reversible hardware description language-based designs

DEFF Research Database (Denmark)

Wille, Robert; Keszocze, Oliver; Othmer, Lars

2017-01-01

to significantly different design challenges to be addressed. In this work, we consider problems that occur when describing a reversible control flow using Hardware Description Languages (HDLs). Here, the commonly used conditional statements must, in addition to the established if-condition for forward computation......, be provided with an additional fi-condition for backward computation. Unfortunately, deriving correct and consistent fi-conditions is often not obvious. Moreover, HDL descriptions exist which may not be realized with a reversible control flow at all. In this work, we propose automatic solutions, which...

Electromagnetic treatment to old Alzheimer's mice reverses β-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit.

Directory of Open Access Journals (Sweden)

Gary W Arendash

Full Text Available Few studies have investigated physiologic and cognitive effects of "long-term" electromagnetic field (EMF exposure in humans or animals. Our recent studies have provided initial insight into the long-term impact of adulthood EMF exposure (GSM, pulsed/modulated, 918 MHz, 0.25-1.05 W/kg by showing 6+ months of daily EMF treatment protects against or reverses cognitive impairment in Alzheimer's transgenic (Tg mice, while even having cognitive benefit to normal mice. Mechanistically, EMF-induced cognitive benefits involve suppression of brain β-amyloid (Aβ aggregation/deposition in Tg mice and brain mitochondrial enhancement in both Tg and normal mice. The present study extends this work by showing that daily EMF treatment given to very old (21-27 month Tg mice over a 2-month period reverses their very advanced brain Aβ aggregation/deposition. These very old Tg mice and their normal littermates together showed an increase in general memory function in the Y-maze task, although not in more complex tasks. Measurement of both body and brain temperature at intervals during the 2-month EMF treatment, as well as in a separate group of Tg mice during a 12-day treatment period, revealed no appreciable increases in brain temperature (and no/slight increases in body temperature during EMF "ON" periods. Thus, the neuropathologic/cognitive benefits of EMF treatment occur without brain hyperthermia. Finally, regional cerebral blood flow in cerebral cortex was determined to be reduced in both Tg and normal mice after 2 months of EMF treatment, most probably through cerebrovascular constriction induced by freed/disaggregated Aβ (Tg mice and slight body hyperthermia during "ON" periods. These results demonstrate that long-term EMF treatment can provide general cognitive benefit to very old Alzheimer's Tg mice and normal mice, as well as reversal of advanced Aβ neuropathology in Tg mice without brain heating. Results further underscore the potential for EMF

Reverse Logistics: An Analysis of Published Articles at the Spell Base

Directory of Open Access Journals (Sweden)

Isabel Teresinha Dutra Soares

2016-07-01

Full Text Available Reverse Logistics (RL is a relatively new topic in academic studies and has had in Brazil its greatest prominence with the National Policy on Solid Waste. This article aims to verify, in 47 articles from the Spell base, published between 2003 until September 2015, how Reverse Logistic has been studied. It was noticed that researchers seem to have problems in searching RL in daily consumption issues (such as, for example, vehicle lubricating oil disposal, lamps, glass, plastic and packaging. It turned out that the RL theme can still be more fully explored due to the diversities and specificities on the involved sectors, functions and flows in the reverse supply chain. Future studies may address more issues, such as the impact of Brazilian legislation and actions towards a green and eco-efficient Reverse Logistic.

Response to comment on 'Magnetic topology effects on Alcator C-Mod scrape-off layer flow'

International Nuclear Information System (INIS)

Simakov, Andrei N; Catto, Peter J

2009-01-01

In his comment to our recent work (Simakov et al 2008 Plasma Phys. Control. Fusion 50 105010), Aydemir has asserted that poloidal plasma flow reversal is not a valid response to toroidal magnetic field reversal in an up-down symmetric tokamak, and that the toroidal plasma flow must reverse instead. We show that this assertion is wrong due to his misunderstanding of the corresponding symmetry transformation. (reply)

A study of bauxite tailing quality improvement by reverse flotation

Science.gov (United States)

Wulandari, W.; Purwasasmita, M.; Sanwani, E.; Malatsih, W.; Fadilla, F.

2018-01-01

The pre-treatment of bauxite ore from Tayan, West Kalimantan includes washing and screening fine bauxite particles (-2mm) prior as the feed to the Bayer process for producing alumina. These fine particles are believed to have high content of silica which is detrimental to the process. This washed bauxite tailing still has a significant amount of alumina content. Previous research has indicated that bauxite ore can be upgraded by applying reverse flotation method to reduce its silica content in the ore. Therefore, this study is aimed to utilize reverse flotation method to recover alumina content from washed bauxite tailing. The reverse flotation experiments were carried out at pH of 6 and 8; while the particle sizes were varied at - 140+270 mesh and -270 mesh, using a batch and circuit configuration. The result of this study shows that the batch reverse flotation can recover alumina in the tailing up to 81.4%, however the silica content is still significant. The complexity of silica-alumina minerals in the tailing prevents a complete separation of the ores by only using reverse flotation.

Managing reversal of direct oral anticoagulants in emergency situations Anticoagulation Education Task Force White Paper

NARCIS (Netherlands)

Ageno, Walter; Büller, Harry R.; Falanga, Anna; Hacke, Werner; Hendriks, Jeroen; Lobban, Trudie; Merino, Jose; Milojevic, Ivan S.; Moya, Francisco; van der Worp, H. Bart; Randall, Gary; Tsioufis, Konstantinos; Verhamme, Peter; Camm, A. John

2016-01-01

Anticoagulation is the cornerstone of prevention and treatment of venous thromboembolism (VTE) and stroke prevention in patients with atrial fibrillation (AF). However, the mechanisms by which anticoagulants confer therapeutic benefit also increase the risk of bleeding. As such, reversal strategies

Reversed-field multiple mirror concept

International Nuclear Information System (INIS)

Steinhauer, L.C.; Grossmann, W.; Seyler, C.E.

1978-01-01

The reversed-field multiple mirror (RFMM), is a promising technique for end-stoppering linear magnetic fusion plasmas. By this means the physics and engineering advantages of a linear plasma are gained while circumventing the endloss problem, allowing the projection of very short (less than or equal to 100 m) conceptual reactors. RFMM end-stoppering is accomplished by a string of closed field-line cells on the plasma column axis; these cells strongly retard the axial flow of particles and energy. We describe the reactor implications of the RFMM

The reversible P2Y12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.

Science.gov (United States)

Rey, Markus; Kramberg, Markus; Hess, Patrick; Morrison, Keith; Ernst, Roland; Haag, Franck; Weber, Edgar; Clozel, Martine; Baumann, Martine; Caroff, Eva; Hubler, Francis; Riederer, Markus A; Steiner, Beat

2017-10-01

The P2Y 12 receptor is a validated target for prevention of major adverse cardiovascular events in patients with acute coronary syndrome. The aim of this study was to compare two direct-acting, reversible P2Y 12 antagonists, ACT-246475 and ticagrelor, in a rat thrombosis model by simultaneous quantification of their antithrombotic efficacy and surgery-induced blood loss. Blood flow velocity was assessed in the carotid artery after FeCl 3 -induced thrombus formation using a Doppler flow probe. At the same time, blood loss after surgical wounding of the spleen was quantified. Continuous infusions of ACT-246475 and ticagrelor prevented the injury-induced reduction of blood flow in a dose-dependent manner. High doses of both antagonists normalized blood flow and completely abolished thrombus formation as confirmed by histology. Intermediate doses restored baseline blood flow to ≥65%. However, ACT-246475 caused significantly less increase of blood loss than ticagrelor; the difference in blood loss was 2.6-fold (P ACT-246475 and ticagrelor on vascular tone. At concentrations needed to achieve maximal antithrombotic efficacy, ticagrelor compared with ACT-246475 significantly increased carotid blood flow velocity in vivo (P = 0.003), induced vasorelaxation of precontracted rat femoral arteries, and inhibited contraction of femoral artery induced by electrical field stimulation or by phenylephrine. Overall, ACT-246475 showed a significantly wider therapeutic window than ticagrelor. The absence of vasodilatory effects due to high selectivity of ACT-246475 for P2Y 12 provides potential arguments for the observed safety advantage of ACT-246475 over ticagrelor. © 2017 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics.

Doing ecohydrology backward: Inferring wetland flow and hydroperiod from landscape patterns

Science.gov (United States)

Acharya, Subodh; Kaplan, David A.; Jawitz, James W.; Cohen, Matthew J.

2017-07-01

Human alterations to hydrology have globally impacted wetland ecosystems. Preventing or reversing these impacts is a principal focus of restoration efforts. However, restoration effectiveness is often hampered by limited information on historical landscape properties and hydrologic regime. To help address this gap, we developed a novel statistical approach for inferring flows and inundation frequency (i.e., hydroperiod, HP) in wetlands where changes in spatial vegetation and geomorphic patterns have occurred due to hydrologic alteration. We developed an analytical expression for HP as a transformation of the landscape-scale stage-discharge relationship. We applied this model to the Everglades "ridge-slough" (RS) landscape, a patterned, lotic peatland in southern Florida that has been drastically degraded by compartmentalization, drainage, and flow diversions. The new method reliably estimated flow and HP for a range of RS landscape patterns. Crucially, ridge-patch anisotropy and elevation above sloughs were strong drivers of flow-HP relationships. Increasing ridge heights markedly increased flow required to achieve sufficient HP to support peat accretion. Indeed, ridge heights inferred from historical accounts would require boundary flows 3-4 times greater than today, which agrees with restoration flow estimates from more complex, spatially distributed models. While observed loss of patch anisotropy allows HP targets to be met with lower flows, such landscapes likely fail to support other ecological functions. This work helps inform restoration flows required to restore stable ridge-slough patterning and positive peat accretion in this degraded ecosystem, and, more broadly, provides tools for exploring interactions between landscape and hydrology in lotic wetlands and floodplains.

Make peak flow a habit

Science.gov (United States)

Asthma - make peak flow a habit; Reactive airway disease - peak flow; Bronchial asthma - peak flow ... 2014:chap 55. National Asthma Education and Prevention Program website. How to use a peak flow meter. ...

RISKS AND CONTRADICTORY OF INTERNATIONAL CAPITAL FLOWS IN BANKING

Directory of Open Access Journals (Sweden)

V. Shevchenko

2014-03-01

Full Text Available The content of the international capital flows are studied, its contradictor influence on global and national processes. Some theoretical approaches on contradictory impact of capital flows. The major risks of international capital flows in banking sector are determined including financial, currency, assets value decrease, credit rating etc. The capital flows reversal flows are explained. The modern changes of international capital flows to banking sector of Ukraine are discovered.

PPARγ agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation.

Science.gov (United States)

Legchenko, Ekaterina; Chouvarine, Philippe; Borchert, Paul; Fernandez-Gonzalez, Angeles; Snay, Erin; Meier, Martin; Maegel, Lavinia; Mitsialis, S Alex; Rog-Zielinska, Eva A; Kourembanas, Stella; Jonigk, Danny; Hansmann, Georg

2018-04-25

Right ventricular (RV) heart failure is the leading cause of death in pulmonary arterial hypertension (PAH). Peroxisome proliferator-activated receptor γ (PPARγ) acts as a vasoprotective metabolic regulator in smooth muscle and endothelial cells; however, its role in the heart is unclear. We report that deletion of PPARγ in cardiomyocytes leads to biventricular systolic dysfunction and intramyocellular lipid accumulation in mice. In the SU5416/hypoxia (SuHx) rat model, oral treatment with the PPARγ agonist pioglitazone completely reverses severe PAH and vascular remodeling and prevents RV failure. Failing RV cardiomyocytes exhibited mitochondrial disarray and increased intramyocellular lipids (lipotoxicity) in the SuHx heart, which was prevented by pioglitazone. Unbiased ventricular microRNA (miRNA) arrays, mRNA sequencing, and lipid metabolism studies revealed dysregulation of cardiac hypertrophy, fibrosis, myocardial contractility, fatty acid transport/oxidation (FAO), and transforming growth factor-β signaling in the failing RV. These epigenetic, transcriptional, and metabolic alterations were modulated by pioglitazone through miRNA/mRNA networks previously not associated with PAH/RV dysfunction. Consistently, pre-miR-197 and pre-miR-146b repressed genes that drive FAO ( Cpt1b and Fabp4 ) in primary cardiomyocytes. We recapitulated our major pathogenic findings in human end-stage PAH: (i) in the pressure-overloaded failing RV (miR-197 and miR-146b up-regulated), (ii) in peripheral pulmonary arteries (miR-146b up-regulated, miR-133b down-regulated), and (iii) in plexiform vasculopathy (miR-133b up-regulated, miR-146b down-regulated). Together, PPARγ activation can normalize epigenetic and transcriptional regulation primarily related to disturbed lipid metabolism and mitochondrial morphology/function in the failing RV and the hypertensive pulmonary vasculature, representing a therapeutic approach for PAH and other cardiovascular/pulmonary diseases. Copyright

Laser heating of field-reversed configurations

International Nuclear Information System (INIS)

Carson, R.S.; Vlases, G.C.

1983-01-01

The experimental facility is a 21-cm-long solenoid with a 5.5-cm bore. The 4-cm ID quartz tube is filled with slowly flowing H 2 to 0.5-3.0 torr. Fields up to 6.5 T in 3.7 μsec are produced, with reverse-bias fields up -1.9 T. Preionization is by 40kA axial discharge 4.5 μsec before field-reversal is begun. The CO 2 laser used produces 300 to 400 J in 2 μsec, in an annular beam that can be defocused for preheating the outer edges of the plasma, or focused tightly for central-column heating and beam propagation during formation. The focusing system includes a return mirror for multiple passing of the laser energy. Diagnostics include compensated, diamagnetic flux loops, internal field probes, cross-tube and axial interferometers, fast photography, and spectroscopy

Does Deccan Volcanic Sequence contain more reversals than the three-Chron N-R-N flow magnetostratigraphy?- A paleomagnetic evidence from the dyke-swarm near Mumbai

Science.gov (United States)

Basavaiah, N.; Satyanarayana, KVV; Deenadayalan, K.; Prasad, JN

2018-02-01

New paleomagnetic data from a series of Deccan-age dykes cutting across the basement of lava flows along east and south of Mumbai (18°-19° N and 72°-73.5° E) have uncovered both normal (N) and reverse (R) magnetizations. Out of 33 dykes investigated, 29 dykes have yielded stable characteristic remanent magnetizations (ChRM) amenable for statistical analysis. Twenty dykes exhibit N-polarity and nine dykes show R-polarity. The tilt-corrected dyke VGPs reveal two distinct groups of dykes. Each group consists of both N- and R- polarity dykes on the Indian Apparent Polar Wander Path (APWP). The mean of N-polarity dykes is antipodal to the mean of R-polarity dykes. Group I (GI) comprises nine N-polarity dykes with their mean at Dm = 337.8°, Im = -39.4° (k = 130.7, α95 = 4.5°), and three dykes of R-polarity whose mean is at Dm = 150.7°, Im = 44.1° (k = 147.1, α95 = 10.2°). The corresponding pole positions are at 43.5° S, 102.6° E (A95 = 4.6°) and 36.6° S, 107.6° E (A95 = 8.9°) respectively. These pole positions fall close to 65 Ma old Deccan Superpole (DSP) on the APWP, and may therefore be associated with magnetic Chron 29 N for the N-polarity and 29R for the R-polarity of the three-Chron (30N - 29R -29Ν) magnetostratigraphy of the Deccan Volcanic Province (DVP) used in the computation of DSP. In Group II (GII), eleven dykes display N-polarity with mean at Dm = 312.6°, Im = -45.2° (k = 93.3, α95 = 4.8°) and six dykes show R-polarity with mean at Dm = 130.1°, Im = 48.0° (k = 176.8, α95 = 5.1°). The corresponding pole positions at 25° S, 120.1° E (A95 = 5.3°) and 22.2° S, 119.1° E (A95 = 5.2°) respectively are significantly displaced (by more than 20°) from the DSP along the older segment (˜80 -90 Ma) of the Indian APWP. Hence, the dykes of GII appear to have been emplaced in an earlier episodic Deccan activity than that represented by the DSP. The paleolatituides corresponding to GI and GII are 23.2° S ± 4.0 and 27.6° S ± 4

An experimental study on the negative effects of downwards flow of the melted frost over a multi-circuit outdoor coil in an air source heat pump during reverse cycle defrosting

International Nuclear Information System (INIS)

Song, Mengjie; Pan, Dongmei; Li, Ning; Deng, Shiming

2015-01-01

Highlights: • A special experimental rig was built and its details are reported. • The negative effects of downwards flowing of the melted frost were shown. • Defrosting duration was shortened after installing water collecting trays. • Temperature of melted frost decreased after installing trays. - Abstract: When the surface temperature of the outdoor coil in an air source heat pump (ASHP) unit is lower than both freezing point of water and the air dew point, frost can be formed and accumulated over outdoor coil surface. Frosting affects the energy efficiency, and periodic defrosting therefore is necessary. Reverse cycle defrosting is currently the most widely used defrosting method. A previous related study has indicated that during reverse cycle defrosting, downwards flow of the melted frost over a multi-circuit outdoor coil could affect the defrosting performance, without however giving detailed quantitative analysis of the effects. Therefore an experimental study on the effects has been carried out and a quantitative analysis conducted using the experimental data. In this paper, the detailed description of an experimental ASHP unit which was specifically built up is firstly reported. This is followed by presenting experimental results. Result analysis and conclusions are finally given

Experimental study on representation of flow on the bifurcated carotid arterial phantoms using magnetic resonance angiography

International Nuclear Information System (INIS)

Chung, Tae Sub; Rhim, Yoon Chul; Kim, Kyung Oh; Suh, Sang Ho; Jin, En Hao

1995-01-01

A common finding of carotid artery on magnetic resonance angiograms(MRAs) is a signal dropout along the posterior wall of carotid bulb due to reverse flow. The purpose of this study is to evaluate variable flow patterns on bifurcated carotid arterial phantoms using steady-state flow. We designed phantoms of a bifurcated carotid artery with acrylic materials. Flow patterns were evaluated with axial and coronal imaging of MRA(2D-TOF, 3D-TOF), color Doppler imaging, and computational fluid dynamics (CFD) within the phantoms constructed of an automated closed-type circulatory system filled with 4% sugar solution. These findings were compared with findings obtained from normal volunteers. Axial 3D-TOF MRA images exhibited closer resemblance to the contour of the inner wall of phantoms when compared to coronal 2D-TOF MRA imaging. However, 2D-TOF MRA showed good contrast difference of signal intensities between forward flow area and reverse flow area. Dark zones with reduced signal intensities due to reversed flow were separated from the outer wall of the internal and external carotid arteries by a thin layer of forward flow along the wall on the source slice image of MRA. The general hemodynamics of the phantoms on MRA were identical to hemodynamics on color Doppler imaging and CFD. The results obtained with the phantoms matched the findings on normal volunteers. Although representations of bifurcated carotid arterial phantoms on axial 3D-TOF MRA were excellent if ideally designed, the zone of reversed flow could be a significant factor in creating distorted image when the zone of reversed flow contacted directly with curved or deformed arterial wall

Hydrodynamic of a deformed bubble in linear shear flow

International Nuclear Information System (INIS)

Adoua, S.R.

2007-07-01

This work is devoted to the study of an oblate spheroidal bubble of prescribed shape set fixed in a linear shear flow using direct numerical simulation. The three dimensional Navier-Stokes equations are solved in orthogonal curvilinear coordinates using a finite volume method. The bubble response is studied over a wide range of the aspect ratio (1-2.7), the bubble Reynolds number (50-2000) and the non-dimensional shear rate (0.-1.2). The numerical simulations shows that the shear flow imposes a plane symmetry of the wake whatever the parameters of the flow. The trailing vorticity is organized into two anti-symmetrical counter rotating tubes with a sign imposed by the competition of two mechanisms (the Lighthill mechanism and the instability of the wake). Whatever the Reynolds number, the lift coefficient reaches the analytical value obtained in an inviscid, weakly sheared flow corresponding to a lift force oriented in the same direction as that of a spherical bubble. For moderate Reynolds numbers, the direction of the lift force reverses when the bubble aspect ratio is large enough as observed in experiments. This reversal occurs for aspect ratios larger than 2.225 and is found to be directly linked to the sign of the trailing vorticity which is concentrated within two counter-rotating threads which propel the bubble in a direction depending of their sign of rotation. The behavior of the drag does not revel any significant effect induced by the wake structure and follows a quadratic increase with the shear rate. Finally, the torque experienced by the bubble also reverses for the same conditions inducing the reversal of the lift force. By varying the orientation of the bubble in the shear flow, a stable equilibrium position is found corresponding to a weak angle between the small axis of the bubble and the flow direction. (author)

Phase lag control of tidally reversing mega-ripple geometry and bed stress in tidal inlets

Science.gov (United States)

Traykovski, P.

2016-02-01

Recent observations in the Columbia River Mouth, New River Inlet, and Wasque Shoals have shown that tidally reversing mega-ripples are an ubiquitous bedform morphology in energetic tidal inlets. As the name implies, these bedforms reverse asymmetry and migration direction in each half tidal cycle. With wavelengths of 2 to 5 m and heights of 0.2 to 0.5 m, these bedforms are larger than current formed ripples, but smaller than dunes. Unlike dunes which have a depth dependent geometry, observations indicate the tidally reversing mega-ripples geometry is related to the time dependent tidal flow and independent of depth. Previous empirical relations for predicting the geometry of ripples or dunes do not successfully predict the geometry of these features. A time dependent geometric model was developed that accounts for the reversal of migration and asymmetry to successfully predict bedform geometry. The model requires sufficient sediment transport in each half tidal cycle to reverse the asymmetry before the bedforms begin to grow. Both the observations and model indicate that the complete reversal of asymmetry and development of a steep lee face occurs near or after maximum flow in each half tidal cycle. This phase lag in bedform response to tidal forcing also has important implications for bed stress in tidal inlets. Observations of frictional drag in the Columbia River mouth based on a tidal momentum balance of surface slope over 10 km regressed against quadratic near bed velocity show drag coefficients that fall off as CD U-1.4. Reynolds stress measurements performed using the dual ADV differencing technique show similar relations. The Reynolds stress measurements also show a dramatic asymmetry between accelerating flows and decelerating flows with a factor of 5 increase during deceleration. Pulse coherent Doppler profiles of near bed turbulence indicate that the turbulence is dominated by energetic fluctuations in separation zones downstream of steep lee faces. The

Magnetic Check Valve

Science.gov (United States)

Morris, Brian G.; Bozeman, Richard J., Jr.

1994-01-01

Poppet in proposed check valve restored to closed condition by magnetic attraction instead of spring force. Oscillations suppressed, with consequent reduction of wear. Stationary magnetic disk mounted just upstream of poppet, also containing magnet. Valve body nonmagnetic. Forward pressure or flow would push poppet away from stationary magnetic disk so fluid flows easily around poppet. Stop in valve body prevents poppet from being swept away. When flow stopped or started to reverse, magnetic attraction draws poppet back to disk. Poppet then engages floating O-ring, thereby closing valve and preventing reverse flow. Floating O-ring facilitates sealing at low loads.

Cessations and reversals of the large-scale circulation in turbulent thermal convection.

Science.gov (United States)

Xi, Heng-Dong; Xia, Ke-Qing

2007-06-01

We present an experimental study of cessations and reversals of the large-scale circulation (LSC) in turbulent thermal convection in a cylindrical cell of aspect ratio (Gamma) 1/2 . It is found that cessations and reversals of the LSC occur in Gamma = 1/2 geometry an order-of-magnitude more frequently than they do in Gamma=1 cells, and that after a cessation the LSC is most likely to restart in the opposite direction, i.e., reversals of the LSC are the most probable cessation events. This contrasts sharply to the finding in Gamma=1 geometry and implies that cessations in the two geometries are governed by different dynamics. It is found that the occurrence of reversals is a Poisson process and that a stronger rebound of the flow strength after a reversal or cessation leads to a longer period of stability of the LSC. Several properties of reversals and cessations in this system are found to be statistically similar to those of geomagnetic reversals. A direct measurement of the velocity field reveals that a cessation corresponds to a momentary decoherence of the LSC.

Reverse Logistics

OpenAIRE

Kulikova, Olga

2016-01-01

This thesis was focused on the analysis of the concept of reverse logistics and actual reverse processes which are implemented in mining industry and finding solutions for the optimization of reverse logistics in this sphere. The objective of this paper was the assessment of the development of reverse logistics in mining industry on the example of potash production. The theoretical part was based on reverse logistics and mining waste related literature and provided foundations for further...

Rapid transporter regulation prevents substrate flow traffic jams in boron transport

Science.gov (United States)

Sotta, Naoyuki; Duncan, Susan; Tanaka, Mayuki; Sato, Takafumi

2017-01-01

Nutrient uptake by roots often involves substrate-dependent regulated nutrient transporters. For robust uptake, the system requires a regulatory circuit within cells and a collective, coordinated behaviour across the tissue. A paradigm for such systems is boron uptake, known for its directional transport and homeostasis, as boron is essential for plant growth but toxic at high concentrations. In Arabidopsis thaliana, boron uptake occurs via diffusion facilitators (NIPs) and exporters (BORs), each presenting distinct polarity. Intriguingly, although boron soil concentrations are homogenous and stable, both transporters manifest strikingly swift boron-dependent regulation. Through mathematical modelling, we demonstrate that slower regulation of these transporters leads to physiologically detrimental oscillatory behaviour. Cells become periodically exposed to potentially cytotoxic boron levels, and nutrient throughput to the xylem becomes hampered. We conclude that, while maintaining homeostasis, swift transporter regulation within a polarised tissue context is critical to prevent intrinsic traffic-jam like behaviour of nutrient flow. PMID:28870285

Large Eddy Simulation of Flow Structures in the Sydney Swirl Burner

DEFF Research Database (Denmark)

Yang, Yang

. The theories of LES and the corresponding closure models have been well developed. This research focuses on statistical analysing flow field and characteristic features. Validation studies show good agreement in the isothermal cases, while for the reacting case, the LES predictions are less satisfactory...... zone which starts at the burner surface. As for the medium swirling isothermal case, there are two reverse flow zones in the reacting case. Due to the low stoichiometric mixture fraction in the methane flame, only the outer layer of the bluff‐body induced reverse zone is reactive. The main reactive...... method strategy has limitations concerning wall bounded flows, especially for complex geometries typically found in industry. Multi‐phase flows need special treatment....

SandBlaster: Reversing the Apple Sandbox

OpenAIRE

Deaconescu, Răzvan; Deshotels, Luke; Bucicoiu, Mihai; Enck, William; Davi, Lucas; Sadeghi, Ahmad-Reza

2016-01-01

In order to limit the damage of malware on Mac OS X and iOS, Apple uses sandboxing, a kernel-level security layer that provides tight constraints for system calls. Particularly used for Apple iOS, sandboxing prevents apps from executing potentially dangerous actions, by defining rules in a sandbox profile. Investigating Apple's built-in sandbox profiles is difficult as they are compiled and stored in binary format. We present SandBlaster, a software bundle that is able to reverse/decompile Ap...

Enhanced confinement with plasma biasing in the MST reversed field pinch

International Nuclear Information System (INIS)

Craig, D.; Almagri, A.F.; Anderson, J.K.

1997-06-01

We report an increase in particle confinement with plasma biasing in a reversed field pinch. Miniature plasma sources are used as electrodes to negatively bias the plasma at the edge (r/a ∼ 0.9). Particle content increases and H α radiation decreases upon application of bias and global particle confinement roughly doubles as a result. Measurements of plasma potential, impurity flow, and floating potential fluctuations indicate that strong flows are produced and that electrostatic fluctuations are reduced

Flow-around modes for a rhomboid wing with a stall vortex in the shock layer

Science.gov (United States)

Zubin, M. A.; Maximov, F. A.; Ostapenko, N. A.

2017-12-01

The results of theoretical and experimental investigation of an asymmetrical hypersonic flow around a V-shaped wing with the opening angle larger than π on the modes with attached shockwaves on forward edges, when the stall flow is implemented on the leeward wing cantilever behind the kink point of the cross contour. In this case, a vortex of nonviscous nature is formed in which the velocities on the sphere exceeding the speed of sound and resulting in the occurrence of pressure shocks with an intensity sufficient for the separation of the turbulent boundary layer take place in the reverse flow according to the calculations within the framework of the ideal gas. It is experimentally established that a separation boundary layer can exist in the reverse flow, and its structure is subject to the laws inherent to the reverse flow in the separation region of the turbulent boundary layer arising in the supersonic conic flow under the action of a shockwave incident to the boundary layer.

MODIFIED REVERSE OSMOSIS SYSTEM FOR TREATMENT OF PRODUCED WATERS

Energy Technology Data Exchange (ETDEWEB)

T.M. Whitworth; Liangxiong Li

2002-09-15

This report describes work performed during the second year of the project ''Modified reverse osmosis system for treatment of produced waters.'' We performed two series of reverse osmosis experiments using very thin bentonite clay membranes compacted to differing degrees. The first series of 10 experiments used NaCl solutions with membranes that ranged between 0.041 and 0.064mm in thickness. Our results showed compaction of such ultra-thin clay membranes to be problematic. The thickness of the membranes was exceeded by the dimensional variation in the machined experimental cell and this is believed to have resulted in local bypassing of the membrane with a resultant decrease in solute rejection efficiency. In two of the experiments, permeate flow was varied as a percentage of the total flow to investigate results of changing permeate flow on solute rejection. In one experiment, the permeate flow was varied between 2.4 and 10.3% of the total flow with no change in solute rejection. In another experiment, the permeate flow was varied between 24.6 and 52.5% of the total flow. In this experiment, the solute rejection rate decreased as the permeate occupied greater fractions of the total flow. This suggests a maximum solute rejection efficiency for these clay membranes for a permeate flow of between 10.3 and 24.6% of the total; flow. Solute rejection was found to decrease with increasing salt concentration and ranged between 62.9% and 19.7% for chloride and between 61.5 and 16.8% for sodium. Due to problems with the compaction procedure and potential membrane bypassing, these rejection rates are probably not the upper limit for NaCl rejection by bentonite membranes. The second series of four reverse osmosis experiments was conducted with a 0.057mm-thick bentonite membrane and dilutions of a produced water sample with an original TDS of 196,250 mg/l obtained from a facility near Loco Hill, New Mexico, operated by an independent. These experiments

Corrosion protected reversing heat exchanger

International Nuclear Information System (INIS)

Zawierucha, R.

1984-01-01

A reversing heat exchanger of the plate and fin type having multiple aluminum parting sheets in a stacked arrangement with corrugated fins separating the sheets to form multiple flow paths, means for closing the ends of the sheets, an input manifold arrangement of headers for the warm end of of the exchanger and an output manifold arrangement for the cold end of the exchanger with the input air feed stream header and the waste gas exhaust header having an alloy of zinc and aluminum coated on the inside surface for providing corrosion protection to the stack

MHD shear flows with non-constant transverse magnetic field

International Nuclear Information System (INIS)

Núñez, Manuel

2012-01-01

Viscous conducting flows parallel to a fixed plate are studied. In contrast with the Hartmann setting, the problem is not linearized near a fixed transverse magnetic field, although the field tends to be transversal far from the wall. While general solutions may be formally obtained for all cases, their behavior is far more clear when the magnetic Prandtl number equals one. We consider two different instances: a fixed magnetic field at the wall, or an insulating sheet. The evolution of the flow and the magnetic field both near the plate and far from it are detailed, analyzing the possibility of reverse flow and instability of the solutions. -- Highlights: ► A conducting shear flow does not leave a transverse magnetic field invariant. ► Solutions are found for all cases, but these are more useful when kinetic and magnetic diffusivities coincide. ► Dirichlet and Neumann conditions on the magnetic field are studied. ► Reverse flow, and eventual instability, are possible.

A study on the characteristics of the flow distribution in the Module Ceramic Filter during filter cleaning

International Nuclear Information System (INIS)

Chung, Jin-Do; Kim, Jang-Woo; Chung, Hwi-Bok; Im, Byoung-Uk; Chung, Eun-Ho; Yoon, Sang-Wook

2010-01-01

Ceramic filter has demonstrated as an attractive system to improve the efficiency and to reduce the effluent pollutants. Removal of particulates from the hot gas stream is very important in air pollution control. In particular, the elimination of the particulate matters discharged from a gas turbine at high temperature can prevent the corrosion the Integrated Gasification Combined Cycle. In this study, a Lab. scale test and numerical simulation were carried out to comprehend the relationship between pulse jet pressure and recovery of pressure drop and to characterize the reverse cleaning flow through a ceramic filter. (author)

Application of computer code ALMOD in transient analysis with reverse flow in the primary loop of nuclear power plant; Primjena programa ALMOD u analizi prijelaznih pojava sa reverzibilnim protokom u primarnom krugu nuklerne elektrane

Energy Technology Data Exchange (ETDEWEB)

Bencik, V [Elektrotehnicki Institut ' Rade Koncar' , Zagreb (Yugoslavia); Feretic, D; Debrecin, N [Elektrotehnicki fakultet, Zagreb (Yugoslavia)

1989-07-01

A computer code ALMOD 3W3 to analyze the transients in which reverse flow in the primary loop of nuclear power plant may occur has been developed. The method to calculate the fluid dynamics in NRC system is presented. The locked rotor accident in one coolant loop is analyzed. (author)

Geomagnetic reversal rates following Palaeozoic superchrons have a fast restart mechanism.

Science.gov (United States)

Hounslow, Mark W

2016-08-30

Long intervals of single geomagnetic polarity (superchrons) reflect geodynamo processes, driven by core-mantle boundary interactions; however, it is not clear what initiates the start and end of superchrons, other than superchrons probably reflect lower heat flow across the core-mantle boundary compared with adjacent intervals. Here geomagnetic polarity timescales, with confidence intervals, are constructed before and following the reverse polarity Kiaman (Carboniferous-Permian) and Moyero (Ordovician) superchrons, providing a window into the geodynamo processes. Similar to the Cretaceous, asymmetry in reversal rates is seen in the Palaeozoic superchrons, but the higher reversal rates imply higher heatflow thresholds for entering the superchron state. Similar to the Cretaceous superchron, unusually long-duration chrons characterize the ∼10 Myr interval adjacent to the superchrons, indicating a transitional reversing state to the superchrons. This may relate to a weak pattern in the clustering of chron durations superimposed on the dominant random arrangement of chron durations.

Annulated Dialkoxybenzenes as Catholyte Materials for Non-aqueous Redox Flow Batteries: Achieving High Chemical Stability through Bicyclic Substitution

International Nuclear Information System (INIS)

Zhang, Jingjing; Yang, Zheng; Shkrob, Ilya A.; Assary, Rajeev S.

2017-01-01

1,4-Dimethoxybenzene derivatives are materials of choice for use as catholytes in nonaqueous redox flow batteries, as they exhibit high open-circuit potentials and excellent electrochemical reversibility. However, chemical stability of these materials in their oxidized form needs to be improved. Disubstitution in the arene ring is used to suppress parasitic reactions of their radical cations, but this does not fully prevent ring-addition reactions. By incorporating bicyclic substitutions and ether chains into the dialkoxybenzenes, a novel catholyte molecule, 9,10-bis(2-methoxyethoxy)-1,2,3,4,5,6,7,8-octahydro-1,4:5, 8-dimethanenoanthracene (BODMA), is obtained and exhibits greater solubility and superior chemical stability in the charged state. As a result, a hybrid flow cell containing BODMA is operated for 150 charge–discharge cycles with minimal loss of capacity.

The treatment of radioactive aqueous wastes by reverse osmosis

International Nuclear Information System (INIS)

Hodgson, T.D.

Experiments were carried out to determine the rejection factors for the more important radionuclides found in aqueous wastes, to study activity deposition within reverse osmosis modules, and to obtain experience in active operation of a reverse osmosis facility. It was found that reverse osmosis is likely to be useful in aqueous radioactive waste treatment when a wide range of contaminants rather than a specific radioactive species must be removed. There appeared to be no barrier to active operation, although greater confidence in the reliability of pumps and membranes is needed. The rejection of trace quantities of radioisotopes such as Cs + or Sr ++ could be predicted from the behaviour of similar inactive ions. Activity present as polyvalent ions or colloidal aggregates is highly rejected by the membrane. Activity may be deposited onto the membrane with insoluble or scaling compounds, and is greatest on areas of the membrane shielded from the sweeping action of the liquor flow

Engineered bio-inspired coating for reduction of flow separation

Science.gov (United States)

Bocanegra Evans, Humberto; Hamed, Ali M.; Gorumlu, Serdar; Doosttalab, Ali; Aksak, Burak; Chamorro, Leonardo P.; Castillo, Luciano

2017-11-01

Flow control using passive strategies has received notable attention in the last decades as a way to increase mixing and reduce skin drag, among others. Here, we present a bio-inspired coating, composed by uniformly distributed pillars with diverging tips, that is able to reduce the recirculation region in highly separated flows. This is demonstrated with laboratory experiments in a refractive index-matching flume at Reynolds number Reθ 1200 . The flow over an expanding channel following a S835 wing section was characterized with the coating and with smooth walls. High-resolution, wall-normal particle image velocimetry show a significant reduction of the reversed flow with the coating, where the region with reverse flow was reduced by 60 % . The performance of the micro-scale coating is surprising since the size of the fibers are nearly coincident with the viscous length scale (k+ 1). Additionally, the flow control properties of the surface do not depend on hydrophobicity, giving the coating the capability to work in both air and water media.

Does Deccan Volcanic Sequence contain more reversals than the three-Chron N-R-N flow magnetostratigraphy?—a palaeomagnetic evidence from the dyke-swarm near Mumbai

Science.gov (United States)

Basavaiah, N.; Satyanarayana, K. VV; Deenadayalan, K.; Prasad, J. N.

2018-06-01

New palaeomagnetic data from a series of Deccan-age dykes cutting across the basement of lava flows along east and south of Mumbai (18°-19°N and 72°-73.5°E) have uncovered both normal (N) and reverse (R) magnetizations. Out of 33 dykes investigated, 29 dykes have yielded stable characteristic remanent magnetizations (ChRM) amenable for statistical analysis. Twenty dykes exhibit N-polarity and nine dykes show R-polarity. The tilt-corrected dyke virtual geomagnetic poles reveal two distinct groups of dykes. Each group consists of both N- and R-polarity dykes on the Indian apparent polar wander path (APWP). The mean of N-polarity dykes is antipodal to the mean of R-polarity dykes. Group I (GI) comprises nine N-polarity dykes with their mean at Dm = 337.8°, Im = -39.4° (k = 130.7, α95 = 4.5°), and three dykes of R-polarity whose mean is at Dm = 150.7°, Im = 44.1° (k = 147.1, α95 = 10.2°). The corresponding pole positions are at 43.5°S, 102.6°E (A95 = 4.6°) and 36.6°S, 107.6°E (A95 = 8.9°) respectively. These pole positions fall close to 65 Ma old Deccan Superpole (DSP) on the APWP, and may therefore be associated with magnetic Chron 29N for the N-polarity and 29R for the R-polarity of the three-Chron (30N-29R-29Ν) magnetostratigraphy of the Deccan Volcanic Province (DVP) used in the computation of DSP. In Group II (GII), eleven dykes display N-polarity with mean at Dm = 312.6°, Im = -45.2° (k = 93.3, α95 = 4.8°) and six dykes show R-polarity with mean at Dm = 130.1°, Im = 48.0° (k = 176.8, α95 = 5.1°). The corresponding pole positions at 25°S, 120.1°E (A95 = 5.3°) and 22.2°S, 119.1°E (A95 = 5.2°) respectively are significantly displaced (by more than 20°) from the DSP along the older segment (˜80-90 Ma) of the Indian APWP. Hence, the dykes of GII appear to have been emplaced in an earlier episodic Deccan activity than that represented by the DSP. The palaeolatituides corresponding to GI and GII are 23.2°S ± 4.0 and 27.6°S ± 4

Reverse logistics: an empirical study for operational framework

International Nuclear Information System (INIS)

Yusuf, I.

2013-01-01

This paper presents framework of reverse logistics optimizing the stakeholders gain, social gain, economic gain and environmental gain. It identifies the roadblocks that prevail in recycling industry and describes various types of returns and wastes. Framework of the reverse logistics is evolved on the basis of actual happening of the items shown in table 1-4 disposed off from industries shown in table 6. The rejected items require environmental disposal passing through the different phases described in flow of operational framework. An operational framework of reverse logistics is developed studying fifty organizations.. In ad -dition three best practices of reverse logistics are proposed by consolidating the experiential information and rich hands on industrial experience in supply chain and reverse logistics area. The research has proposed the Social, Stakeholder, Economic and Environmental (SSEE) sustained gain model optimizing the benefits of stakeholders and highlights the variety of waste and its operational methodology in Pakistani industry. The proposed framework does not include the hospital waste, radioactive waste, hazardous materials waste, municipal waste, agricultural waste and cold chain waste like meat, milk, etc.The operational framework is existing way of doing that takes the waste materials from point of origin to the point of recycling. A better understanding of this framework may help researchers and front line managers to develop better, more ac -curate models for effective and sustainable utilization of waste materials, benefiting organizations and soci -ety by simultaneously enhancing the cost effectiveness and improving environmental awareness. The paper provides an operational framework of reverse logistics and 2S2E sustained gain model. Specific applications are examined through empirical research. (author)

Palæomagnetism of Hawaiian lava flows

Science.gov (United States)

Doell, Richard R.; Cox, Allan

1961-01-01

PALÆOMAGNETIC investigations of volcanic rocks extruded in various parts of the world during the past several million years have generally revealed a younger sequence of lava flows magnetized nearly parallel to the field of a theoretical geocentric axial dipole, underlain by a sequence of older flows with exactly the opposite direction of remanent magnetization. A 180-degree reversal of the geomagnetic field, occurring near the middle of the Pleistocene epoch, has been inferred by many workers from such results1–3. This is a preliminary report of an investigation of 755 oriented samples collected from 152 lava flows on the island of Hawaii, selected to represent as many stratigraphic horizons as possible. (Sampling details are indicated in Table 1.) This work was undertaken because Hawaii's numerous thick sequences of lava flows, previously mapped as Pliocene to Historic by Stearns and Macdonald4, and afterwards assigned ages ranging from later Tertiary to Recent, by Macdonald and Davis5, appeared to offer an ideal opportunity to examine the most recent reversal of Earth's field.

Chemiluminescence from an oxidation reaction of rhodamine B with cerium(IV) in a reversed micellar medium of cetyltrimethylammonium chloride in 1-hexanol-cyclohexane/water.

Science.gov (United States)

Hasanin, Tamer H A; Tsunemine, Yusuke; Tsukahara, Satoshi; Okamoto, Yasuaki; Fujiwara, Terufumi

2011-01-01

The chemiluminescence (CL) emission, observed when rhodamine B (RB) in 1-hexanol-cyclohexane was mixed with cerium(IV) sulfate in sulfuric acid dispersed in a reversed micellar medium of cetyltrimethylammonium chloride (CTAC) in 1-hexanol-cyclohexane/water, was investigated using a flow-injection system. The CL emission from the oxidation reaction of RB with Ce(IV) was found to be stronger in the CTAC reversed micellar solution compared with an aqueous solution. Bearing on the enhancement effect of the CTAC reverse micelles on the RB-Ce(IV) CL, several studies including stopped-flow, fluorescence and electron spin resonance (ESR) spectrometries were performed. Rapid spectral changes of an intermediate in the RB-Ce(IV) reaction in the aqueous and reversed micellar solutions were successfully observed using a stopped-flow method. The effect of the experimental variables, i.e., oxidant concentration, sulfuric acid concentration, the mole fraction of 1-hexanol, water-to-surfactant molar concentration ratio, flow rate, upon the CL intensity was evaluated. Under the experimental conditions optimized for a flow-injection determination of RB based on the new reversed micellar-mediated CL reaction with Ce(IV), a detection limit of 0.08 µmol dm(-3) RB was achieved, and a linear calibration graph was obtained with a dynamic range from 0.5 to 20 µmol dm(-3). The relative standard deviation (n = 6) obtained at an RB concentration of 3 µmol dm(-3) was 3%.

Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.

Directory of Open Access Journals (Sweden)

Jimcy Platholi

Full Text Available General anesthetics produce a reversible coma-like state through modulation of excitatory and inhibitory synaptic transmission. Recent evidence suggests that anesthetic exposure can also lead to sustained cognitive dysfunction. However, the subcellular effects of anesthetics on the structure of established synapses are not known. We investigated effects of the widely used volatile anesthetic isoflurane on the structural stability of hippocampal dendritic spines, a postsynaptic structure critical to excitatory synaptic transmission in learning and memory. Exposure to clinical concentrations of isoflurane induced rapid and non-uniform shrinkage and loss of dendritic spines in mature cultured rat hippocampal neurons. Spine shrinkage was associated with a reduction in spine F-actin concentration. Spine loss was prevented by either jasplakinolide or cytochalasin D, drugs that prevent F-actin disassembly. Isoflurane-induced spine shrinkage and loss were reversible upon isoflurane elimination. Thus, isoflurane destabilizes spine F-actin, resulting in changes to dendritic spine morphology and number. These findings support an actin-based mechanism for isoflurane-induced alterations of synaptic structure in the hippocampus. These reversible alterations in dendritic spine structure have important implications for acute anesthetic effects on excitatory synaptic transmission and synaptic stability in the hippocampus, a locus for anesthetic-induced amnesia, and have important implications for anesthetic effects on synaptic plasticity.

Interplay of Coulomb interactions and disorder in three-dimensional quadratic band crossings without time-reversal symmetry and with unequal masses for conduction and valence bands

Science.gov (United States)

Mandal, Ipsita; Nandkishore, Rahul M.

2018-03-01

Coulomb interactions famously drive three-dimensional quadratic band crossing semimetals into a non-Fermi liquid phase of matter. In a previous work [Nandkishore and Parameswaran, Phys. Rev. B 95, 205106 (2017), 10.1103/PhysRevB.95.205106], the effect of disorder on this non-Fermi liquid phase was investigated, assuming that the band structure was isotropic, assuming that the conduction and valence bands had the same band mass, and assuming that the disorder preserved exact time-reversal symmetry and statistical isotropy. It was shown that the non-Fermi liquid fixed point is unstable to disorder and that a runaway flow to strong disorder occurs. In this paper, we extend that analysis by relaxing the assumption of time-reversal symmetry and allowing the electron and hole masses to differ (but continuing to assume isotropy of the low energy band structure). We first incorporate time-reversal symmetry breaking disorder and demonstrate that there do not appear any new fixed points. Moreover, while the system continues to flow to strong disorder, time-reversal-symmetry-breaking disorder grows asymptotically more slowly than time-reversal-symmetry-preserving disorder, which we therefore expect should dominate the strong-coupling phase. We then allow for unequal electron and hole masses. We show that whereas asymmetry in the two masses is irrelevant in the clean system, it is relevant in the presence of disorder, such that the `effective masses' of the conduction and valence bands should become sharply distinct in the low-energy limit. We calculate the RG flow equations for the disordered interacting system with unequal band masses and demonstrate that the problem exhibits a runaway flow to strong disorder. Along the runaway flow, time-reversal-symmetry-preserving disorder grows asymptotically more rapidly than both time-reversal-symmetry-breaking disorder and the Coulomb interaction.

Insertable fluid flow passage bridgepiece and method

Science.gov (United States)

Jones, Daniel O.

2000-01-01

A fluid flow passage bridgepiece for insertion into an open-face fluid flow channel of a fluid flow plate is provided. The bridgepiece provides a sealed passage from a columnar fluid flow manifold to the flow channel, thereby preventing undesirable leakage into and out of the columnar fluid flow manifold. When deployed in the various fluid flow plates that are used in a Proton Exchange Membrane (PEM) fuel cell, bridgepieces of this invention prevent mixing of reactant gases, leakage of coolant or humidification water, and occlusion of the fluid flow channel by gasket material. The invention also provides a fluid flow plate assembly including an insertable bridgepiece, a fluid flow plate adapted for use with an insertable bridgepiece, and a method of manufacturing a fluid flow plate with an insertable fluid flow passage bridgepiece.

Reversing the Effect of Oral Anticoagulant Drugs: Established and Newer Options.

Science.gov (United States)

Ansell, Jack E

2016-06-01

The vitamin K antagonists (VKAs) have been the standard (and only) oral anticoagulants used for the long-term treatment or prevention of venous thromboembolism or stroke in patients with atrial fibrillation. The coagulopathy induced by VKAs can be reversed with vitamin K, and in urgent situations, the vitamin K-dependent coagulation factors can be replaced by transfusion. In the last decade, a new class of oral anticoagulants has been developed, direct oral anticoagulants that bind to a specific coagulation factor and neutralize it. These compounds were shown to be effective and safe compared with the VKAs and were licensed for specific indications, but without a specific reversal agent. The absence of a reversal agent is a barrier to more widespread use of these agents. Currently, for the management of major life-threatening bleeding with the direct oral anticoagulants, most authorities recommend the use of four factor prothrombin complex concentrates. There are now three reversal agents in development and poised to enter the market. Idarucizumab is a specific antidote targeted to reverse the direct thrombin inhibitor, dabigatran, which was recently approved for use in the USA. Andexanet alfa is an antidote targeted to reverse the oral direct factor Xa inhibitors as well as the indirect inhibitor enoxaparin. Ciraparantag is an antidote targeted to reverse the direct thrombin and factor Xa inhibitors as well as the indirect inhibitor enoxaparin.

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

Science.gov (United States)

Muñoz-Martínez, Francisco; Lu, Peihua; Cortés-Selva, Fernando; Pérez-Victoria, José María; Jiménez, Ignacio A; Ravelo, Angel G; Sharom, Frances J; Gamarro, Francisco; Castanys, Santiago

2004-10-01

Overexpression of ABCB1 (MDR1) P-glycoprotein, a multidrug efflux pump, is one mechanism by which tumor cells may develop multidrug resistance (MDR), preventing the successful chemotherapeutic treatment of cancer. Sesquiterpenes from Celastraceae family are natural compounds shown previously to reverse MDR in several human cancer cell lines and Leishmania strains. However, their molecular mechanism of reversion has not been characterized. In the present work, we have studied the ability of 28 dihydro-beta-agarofuran sesquiterpenes to reverse the P-glycoprotein-dependent MDR phenotype and elucidated their molecular mechanism of action. Cytotoxicity assays using human MDR1-transfected NIH-3T3 cells allowed us to select the most potent sesquiterpenes reversing the in vitro resistance to daunomycin and vinblastine. Flow cytometry experiments showed that the above active compounds specifically inhibited drug transport activity of P-glycoprotein in a saturable, concentration-dependent manner (K(i) down to 0.24 +/- 0.01 micromol/L) but not that of ABCC1 (multidrug resistance protein 1; MRP1), ABCC2 (MRP2), and ABCG2 (breast cancer resistance protein; BCRP) transporters. Moreover, sesquiterpenes inhibited at submicromolar concentrations the P-glycoprotein-mediated transport of [(3)H]colchicine and tetramethylrosamine in plasma membrane from CH(R)B30 cells and P-glycoprotein-enriched proteoliposomes, supporting that P-glycoprotein is their molecular target. Photoaffinity labeling in plasma membrane and fluorescence spectroscopy experiments with purified protein suggested that sesquiterpenes interact with transmembrane domains of P-glycoprotein. Finally, sesquiterpenes modulated P-glycoprotein ATPase-activity in a biphasic, concentration-dependent manner: they stimulated at very low concentrations but inhibited ATPase activity as noncompetitive inhibitors at higher concentrations. Sesquiterpenes from Celastraceae are promising P-glycoprotein modulators with potential

Reversal of multidrug resistance by surfactants.

Science.gov (United States)

Woodcock, D. M.; Linsenmeyer, M. E.; Chojnowski, G.; Kriegler, A. B.; Nink, V.; Webster, L. K.; Sawyer, W. H.

1992-01-01

Cremophor EL, a pharmacologically inactive solubilising agent, has been shown to reverse multidrug resistance (MDR). Using flow cytometric evaluation of equilibrium intracellular levels of daunorubicin (DNR), we found that eight other surface active agents will also reverse MDR. All the active detergents contain polyethoxylated moieties but have no similarities in their hydrophobic components. The properties of three polyethoxylated surfactants that showed the lowest toxicities, Cremophor, Tween 80 and Solutol HS15, were examined in more detail. The concentrations of Tween 80 and Solutol required to reverse DNR exclusion were 10-fold lower than for Cremophor. However while concentrations greater than or equal to 1:10(2) of the former two surfactants resulted in breakdown of cells, even 1:10 of Cremophor did not lyse cells. Studies of the effects of Cremophor on the uptake and efflux of DNR in normal and MDR cell types showed that Cremophor increases intracellular DNR primarily by locking the rapid efflux from the cells. This blockage of drug efflux may be mediated by a substantial alteration in the fluidity of cell membranes induced by Cremophor, as shown by decreased fluorescence anisotropy of a membrane probe. Consistent with these data, coinjection of adriamycin plus Cremophor into mice carrying a multidrug resistant P388 transplantable tumour significantly increased the survival time of the mice compared with adriamycin treatment alone. PMID:1637678

Blood Cell Interactions and Segregation in Flow

OpenAIRE

Munn, Lance L.; Dupin, Michael M.

2008-01-01

For more than a century, pioneering researchers have been using novel experimental and computational approaches to probe the mysteries of blood flow. Thanks to their efforts, we know that blood cells generally prefer to migrate to the axis of flow, that red and white cells segregate in flow, and that cell deformability and their tendency to reversibly aggregate contribute to the non-Newtonian nature of this unique fluid. All of these properties have beneficial physiological consequences, allo...

Shape Optimization of Three-Way Reversing Valve for Cavitation Reduction

International Nuclear Information System (INIS)

Lee, Myeong Gon; Han, Seung Ho; Lim, Cha Suk

2015-01-01

A pair of two-way valves typically is used in automotive washing machines, where the water flow direction is frequently reversed and highly pressurized clean water is sprayed to remove the oil and dirt remaining on machined engine and transmission blocks. Although this valve system has been widely used because of its competitive price, its application is sometimes restricted by surging effects, such as pressure ripples occurring in rapid changes in water flow caused by inaccurate valve control. As an alternative, one three-way reversing valve can replace the valve system because it provides rapid and accurate changes to the water flow direction without any precise control device. However, a cavitation effect occurs because of the complicated bottom plug shape of the valve. In this study, the cavitation index and percent of cavitation (POC) were introduced to numerically evaluate fluid flows via computational fluid dynamics (CFD) analysis. To reduce the cavitation effect generated by the bottom plug, the optimal shape design was carried out through a parametric study, in which a simple computer-aided engineering (CAE) model was applied to avoid time consuming CFD analysis and difficulties in achieving convergence. The optimal shape design process using full factorial design of experiments (DOEs) and an artificial neural network meta-model yielded the optimal waist and tail length of the bottom plug with a POC value of less than 30%, which meets the requirement of no cavitation occurrence. The optimal waist length, tail length and POC value were found to 6.42 mm, 6.96 mm and 27%, respectively

Shape optimization of three-way reversing valve for cavitation reduction

International Nuclear Information System (INIS)

Lee, Myeong Gon; Han, Seung Ho; Lim, Cha Suk

2015-01-01

A pair of two-way valves typically is used in automotive washing machines, where the water flow direction is frequently reversed and highly pressurized clean water is sprayed to remove the oil and dirt remaining on machined engine and transmission blocks. Although this valve system has been widely used because of its competitive price, its application is sometimes restricted by surging effects, such as pressure ripples occurring in rapid changes in water flow caused by inaccurate valve control. As an alternative, one three-way reversing valve can replace the valve system because it provides rapid and accurate changes to the water flow direction without any precise control device. However, a cavitation effect occurs because of the complicated bottom plug shape of the valve. In this study, the cavitation index and percent of cavitation (POC) were introduced to numerically evaluate fluid flows via computational fluid dynamics (CFD) analysis. To reduce the cavitation effect generated by the bottom plug, the optimal shape design was carried out through a parametric study, in which a simple computer-aided engineering (CAE) model was applied to avoid time-consuming CFD analysis and difficulties in achieving convergence. The optimal shape design process using full factorial design of experiments (DOEs) and an artificial neural network meta-model yielded the optimal waist and tail length of the bottom plug with a POC value of less than 30%, which meets the requirement of no cavitation occurrence. The optimal waist length, tail length and POC value were found to 6.42 mm, 6.96 mm and 27%, respectively

Shape Optimization of Three-Way Reversing Valve for Cavitation Reduction

Energy Technology Data Exchange (ETDEWEB)

Lee, Myeong Gon; Han, Seung Ho [Donga Univ., Busan (Korea, Republic of); Lim, Cha Suk [Baek San Hi-Tech Co., Ltd., Seoul (Korea, Republic of)

2015-11-15

A pair of two-way valves typically is used in automotive washing machines, where the water flow direction is frequently reversed and highly pressurized clean water is sprayed to remove the oil and dirt remaining on machined engine and transmission blocks. Although this valve system has been widely used because of its competitive price, its application is sometimes restricted by surging effects, such as pressure ripples occurring in rapid changes in water flow caused by inaccurate valve control. As an alternative, one three-way reversing valve can replace the valve system because it provides rapid and accurate changes to the water flow direction without any precise control device. However, a cavitation effect occurs because of the complicated bottom plug shape of the valve. In this study, the cavitation index and percent of cavitation (POC) were introduced to numerically evaluate fluid flows via computational fluid dynamics (CFD) analysis. To reduce the cavitation effect generated by the bottom plug, the optimal shape design was carried out through a parametric study, in which a simple computer-aided engineering (CAE) model was applied to avoid time consuming CFD analysis and difficulties in achieving convergence. The optimal shape design process using full factorial design of experiments (DOEs) and an artificial neural network meta-model yielded the optimal waist and tail length of the bottom plug with a POC value of less than 30%, which meets the requirement of no cavitation occurrence. The optimal waist length, tail length and POC value were found to 6.42 mm, 6.96 mm and 27%, respectively.

Shape optimization of three-way reversing valve for cavitation reduction

Energy Technology Data Exchange (ETDEWEB)

Lee, Myeong Gon; Han, Seung Ho [Dept. of Mechanical Engineering, Dong-A University, Busan (Korea, Republic of); Lim, Cha Suk [Baek San Hi-Tech Co., Ltd., Yangsan(Korea, Republic of)

2015-11-15

A pair of two-way valves typically is used in automotive washing machines, where the water flow direction is frequently reversed and highly pressurized clean water is sprayed to remove the oil and dirt remaining on machined engine and transmission blocks. Although this valve system has been widely used because of its competitive price, its application is sometimes restricted by surging effects, such as pressure ripples occurring in rapid changes in water flow caused by inaccurate valve control. As an alternative, one three-way reversing valve can replace the valve system because it provides rapid and accurate changes to the water flow direction without any precise control device. However, a cavitation effect occurs because of the complicated bottom plug shape of the valve. In this study, the cavitation index and percent of cavitation (POC) were introduced to numerically evaluate fluid flows via computational fluid dynamics (CFD) analysis. To reduce the cavitation effect generated by the bottom plug, the optimal shape design was carried out through a parametric study, in which a simple computer-aided engineering (CAE) model was applied to avoid time-consuming CFD analysis and difficulties in achieving convergence. The optimal shape design process using full factorial design of experiments (DOEs) and an artificial neural network meta-model yielded the optimal waist and tail length of the bottom plug with a POC value of less than 30%, which meets the requirement of no cavitation occurrence. The optimal waist length, tail length and POC value were found to 6.42 mm, 6.96 mm and 27%, respectively.

Reversal of androgen inhibition of estrogen-activated sexual behavior by cholinergic agents.

Science.gov (United States)

Dohanich, G P; Cada, D A

1989-12-01

Androgens have been found to inhibit lordosis activated by estrogen treatment of ovariectomized female rats. In the present experiments, dihydrotestosterone propionate (200 micrograms for 3 days) inhibited the incidence of lordosis in ovariectomized females treated with estradiol benzoate (1 microgram for 3 days). This inhibition of lordosis was reversed 15 min after bilateral intraventricular infusion of physostigmine (10 micrograms/cannula), an acetylcholinesterase inhibitor, or carbachol (0.5 microgram/cannula), a cholinergic receptor agonist. This reversal of inhibition appears to be mediated by cholinergic muscarinic receptors since pretreatment with scopolamine (4 mg/kg, ip), a muscarinic receptor blocker, prevented the reversal of androgen inhibition by physostigmine. These results indicate that androgens may inhibit estrogen-activated lordosis through interference with central cholinergic muscarinic mechanisms.

State space analysis of minimal channel flow

Energy Technology Data Exchange (ETDEWEB)

Neelavara, Shreyas Acharya; Duguet, Yohann; Lusseyran, François, E-mail: acharya@limsi.fr [LIMSI-CNRS, Campus Universitaire d’Orsay, Université Paris-Saclay, F-91405 Orsay (France)

2017-06-15

Turbulence and edge states are investigated numerically in a plane Poiseuille flow driven by a fixed pressure gradient. Simulations are carried out within the minimal flow unit, a concept introduced by Jiménez and Moin (1991 J . Fluid Mech. 225 213–40) to unravel the dynamics of near-wall structures in the absence of outer large-scale motions. For both turbulent and edge regimes the activity appears to be localised near only one wall at a time, and the long term dynamics features abrupt reversals. The dynamics along one reversal is structured around the transient visit to a subspace of symmetric flow fields. An exact travelling wave solution is found to exist very close to this subspace. Additionally the self-similarity of the asymmetric states is addressed. Contrary to most studies focusing on symmetric solutions, the present study suggests that edge states, when localised near one wall, do not scale in outer units. The current study suggests a composite scaling. (paper)

Quantum vertex model for reversible classical computing.

Science.gov (United States)

Chamon, C; Mucciolo, E R; Ruckenstein, A E; Yang, Z-C

2017-05-12

Mappings of classical computation onto statistical mechanics models have led to remarkable successes in addressing some complex computational problems. However, such mappings display thermodynamic phase transitions that may prevent reaching solution even for easy problems known to be solvable in polynomial time. Here we map universal reversible classical computations onto a planar vertex model that exhibits no bulk classical thermodynamic phase transition, independent of the computational circuit. Within our approach the solution of the computation is encoded in the ground state of the vertex model and its complexity is reflected in the dynamics of the relaxation of the system to its ground state. We use thermal annealing with and without 'learning' to explore typical computational problems. We also construct a mapping of the vertex model into the Chimera architecture of the D-Wave machine, initiating an approach to reversible classical computation based on state-of-the-art implementations of quantum annealing.

Investigation of turbulent separation in a forward-facing step flow

International Nuclear Information System (INIS)

Pearson, D S; Goulart, P J; Ganapathisubramani, B

2011-01-01

The relation between the upstream and downstream regions of separation of the flow over a forward-facing step is investigated using experimental data. High-speed Particle Image Velocimetry (PIV) data is used to show a correlation between the wall shear stress of the oncoming boundary layer and the streamwise location of reverse flow upstream of the step. The time delay associated with the correlation is consistent with average convection velocities in the lower boundary layer. This suggests that appropriate addition of momentum into the boundary layer could be used to control the spatial extent of the separation upstream of the step. In addition, low-speed PIV data is used to show statistical relations between the flow characteristics of the recirculation regions in the vicinity of the step face. It is shown that a slower than average flow velocity above the step face is associated with an increase in the wall-normal extent of upstream reverse flow, an increase in the inclination of the flow above the step and an increase in downstream vorticity.

Reversible Thermoset Adhesives

Science.gov (United States)

Mac Murray, Benjamin C. (Inventor); Tong, Tat H. (Inventor); Hreha, Richard D. (Inventor)

2016-01-01

Embodiments of a reversible thermoset adhesive formed by incorporating thermally-reversible cross-linking units and a method for making the reversible thermoset adhesive are provided. One approach to formulating reversible thermoset adhesives includes incorporating dienes, such as furans, and dienophiles, such as maleimides, into a polymer network as reversible covalent cross-links using Diels Alder cross-link formation between the diene and dienophile. The chemical components may be selected based on their compatibility with adhesive chemistry as well as their ability to undergo controlled, reversible cross-linking chemistry.

Small organic molecule based flow battery

Science.gov (United States)

Huskinson, Brian; Marshak, Michael; Aziz, Michael J.; Gordon, Roy G.; Betley, Theodore A.; Aspuru-Guzik, Alan; Er, Suleyman; Suh, Changwon

2018-05-08

The invention provides an electrochemical cell based on a new chemistry for a flow battery for large scale, e.g., gridscale, electrical energy storage. Electrical energy is stored chemically at an electrochemical electrode by the protonation of small organic molecules called quinones to hydroquinones. The proton is provided by a complementary electrochemical reaction at the other electrode. These reactions are reversed to deliver electrical energy. A flow battery based on this concept can operate as a closed system. The flow battery architecture has scaling advantages over solid electrode batteries for large scale energy storage.

Functional behavior and reproduction in androgenic sex reversed zebrafish (Danio rerio).

Science.gov (United States)

Larsen, Mia G; Baatrup, Erik

2010-08-01

Endocrine-disrupting chemicals released into natural watercourses may cause biased sex ratios by sex reversal in fish populations. The present study investigated the androgenic sex reversal of zebrafish (Danio rerio) exposed to the androgenic compound 17beta-trenbolone (TB) and whether sex-changed females would revert to the female phenotype after cessation of TB exposure. 17beta-Trenbolone is a metabolite of trenbolone acetate, an anabolic steroid used as a growth promoter in beef cattle. 17beta-Trenbolone in runoff from cattle feedlots may reach concentrations that affect fish sexual development. Zebrafish were exposed to a concentration of 20 ng/L TB in a flow-through system for five months from egg until sexual maturity. This resulted in an all-male population. It was further found that all these phenotypic males displayed normal male courtship behavior and were able to reproduce successfully, implying that the sex reversal was complete and functional. None of the phenotypic males developed into females after six months in clean water, demonstrating that androgenic sex reversal of zebrafish is irreversible. Copyright 2010 SETAC

Zero field reversal probability in thermally assisted magnetization reversal

Science.gov (United States)

Prasetya, E. B.; Utari; Purnama, B.

2017-11-01

This paper discussed about zero field reversal probability in thermally assisted magnetization reversal (TAMR). Appearance of reversal probability in zero field investigated through micromagnetic simulation by solving stochastic Landau-Lifshitz-Gibert (LLG). The perpendicularly anisotropy magnetic dot of 50×50×20 nm3 is considered as single cell magnetic storage of magnetic random acces memory (MRAM). Thermally assisted magnetization reversal was performed by cooling writing process from near/almost Curie point to room temperature on 20 times runs for different randomly magnetized state. The results show that the probability reversal under zero magnetic field decreased with the increase of the energy barrier. The zero-field probability switching of 55% attained for energy barrier of 60 k B T and the reversal probability become zero noted at energy barrier of 2348 k B T. The higest zero-field switching probability of 55% attained for energy barrier of 60 k B T which corespond to magnetif field of 150 Oe for switching.

Amazon river flow regime and flood recessional agriculture: Flood stage reversals and risk of annual crop loss

Science.gov (United States)

Coomes, Oliver T.; Lapointe, Michel; Templeton, Michael; List, Geneva

2016-08-01

The annual flood cycle is an important driver of ecosystem structure and function in large tropical rivers such as the Amazon. Riparian peasant communities rely on river fishing and annual floodplain agriculture, closely adapted to the recession phase of the flood pulse. This article reports on a poorly documented but important challenge facing farmers practicing flood recessional agriculture along the Amazon river: frequent, unpredictable stage reversals (repiquetes) which threaten to ruin crops growing on channel bars. We assess the severity of stage reversals for rice production on exposed river mud bars (barreales) near Iquitos, Peru. Crop loss risk is estimated based on a quantitative analysis of 45 years of daily Amazon stage data and field data from floodplain communities nearby in the Muyuy archipelago, upstream of Iquitos. Rice varieties selected, elevations of silt rich bars where rice is sown, as well as planting and harvest dates are analyzed in the light of the timing, frequencies and amplitudes of observed stage reversals that have the potential to destroy growing rice. We find that unpredictable stage reversals can produce substantial crop losses and shorten significantly the length of average growing seasons on lower elevation river bars. The data reveal that local famers extend planting down to lower bar elevations where the mean probabilities of re-submergence before rice maturity (due to reversals) approach 50%, below which they implicitly consider that the risk of crop loss outweighs the potential reward of planting.

Second law analysis of reverse osmosis desalination plants: An alternative design using pressure retarded osmosis

International Nuclear Information System (INIS)

Sharqawy, Mostafa H.; Zubair, Syed M.; Lienhard, John H.

2011-01-01

A second law analysis of a reverse osmosis desalination plant is carried out using reliable seawater exergy formulation instead of a common model in literature that represents seawater as an ideal mixture of liquid water and solid sodium chloride. The analysis is performed using reverse osmosis desalination plant data and compared with results previously published using the ideal mixture model. It is demonstrated that the previous model has serious shortcomings, particularly with regard to calculation of the seawater flow exergy, the minimum work of separation, and the second law efficiency. The most up-to-date thermodynamic properties of seawater, as needed to conduct an exergy analysis, are given as correlations in this paper. From this new analysis, it is found that the studied reverse osmosis desalination plant has very low second law efficiency (<2%) even when using the available energy recovery systems. Therefore, an energy recovery system is proposed using the (PRO) pressure retarded osmotic method. The proposed alternative design has a second law efficiency of 20%, and the input power is reduced by 38% relative to original reverse osmosis system. -- Highlights: ► A previously proposed model for the calculation of seawater flow exergy gives incorrect values. ► Reverse osmosis desalination plants have very low second law efficiency (<2%) even when using the available energy recovery systems. ► A PRO energy recovery device increases the RO plant’s second law efficiency to 20% and reduces the input power.

Evaluation of multivariate statistical analyses for monitoring and prediction of processes in an seawater reverse osmosis desalination plant

Energy Technology Data Exchange (ETDEWEB)

Kolluri, Srinivas Sahan; Esfahani, Iman Janghorban; Garikiparthy, Prithvi Sai Nadh; Yoo, Chang Kyoo [Kyung Hee University, Yongin (Korea, Republic of)

2015-08-15

Our aim was to analyze, monitor, and predict the outcomes of processes in a full-scale seawater reverse osmosis (SWRO) desalination plant using multivariate statistical techniques. Multivariate analysis of variance (MANOVA) was used to investigate the performance and efficiencies of two SWRO processes, namely, pore controllable fiber filterreverse osmosis (PCF-SWRO) and sand filtration-ultra filtration-reverse osmosis (SF-UF-SWRO). Principal component analysis (PCA) was applied to monitor the two SWRO processes. PCA monitoring revealed that the SF-UF-SWRO process could be analyzed reliably with a low number of outliers and disturbances. Partial least squares (PLS) analysis was then conducted to predict which of the seven input parameters of feed flow rate, PCF/SF-UF filtrate flow rate, temperature of feed water, turbidity feed, pH, reverse osmosis (RO)flow rate, and pressure had a significant effect on the outcome variables of permeate flow rate and concentration. Root mean squared errors (RMSEs) of the PLS models for permeate flow rates were 31.5 and 28.6 for the PCF-SWRO process and SF-UF-SWRO process, respectively, while RMSEs of permeate concentrations were 350.44 and 289.4, respectively. These results indicate that the SF-UF-SWRO process can be modeled more accurately than the PCF-SWRO process, because the RMSE values of permeate flowrate and concentration obtained using a PLS regression model of the SF-UF-SWRO process were lower than those obtained for the PCF-SWRO process.

Evaluation of multivariate statistical analyses for monitoring and prediction of processes in an seawater reverse osmosis desalination plant

International Nuclear Information System (INIS)

Kolluri, Srinivas Sahan; Esfahani, Iman Janghorban; Garikiparthy, Prithvi Sai Nadh; Yoo, Chang Kyoo

2015-01-01

Our aim was to analyze, monitor, and predict the outcomes of processes in a full-scale seawater reverse osmosis (SWRO) desalination plant using multivariate statistical techniques. Multivariate analysis of variance (MANOVA) was used to investigate the performance and efficiencies of two SWRO processes, namely, pore controllable fiber filterreverse osmosis (PCF-SWRO) and sand filtration-ultra filtration-reverse osmosis (SF-UF-SWRO). Principal component analysis (PCA) was applied to monitor the two SWRO processes. PCA monitoring revealed that the SF-UF-SWRO process could be analyzed reliably with a low number of outliers and disturbances. Partial least squares (PLS) analysis was then conducted to predict which of the seven input parameters of feed flow rate, PCF/SF-UF filtrate flow rate, temperature of feed water, turbidity feed, pH, reverse osmosis (RO)flow rate, and pressure had a significant effect on the outcome variables of permeate flow rate and concentration. Root mean squared errors (RMSEs) of the PLS models for permeate flow rates were 31.5 and 28.6 for the PCF-SWRO process and SF-UF-SWRO process, respectively, while RMSEs of permeate concentrations were 350.44 and 289.4, respectively. These results indicate that the SF-UF-SWRO process can be modeled more accurately than the PCF-SWRO process, because the RMSE values of permeate flowrate and concentration obtained using a PLS regression model of the SF-UF-SWRO process were lower than those obtained for the PCF-SWRO process.

Sequential determination of multi-nutrient elements in natural water samples with a reverse flow injection system.

Science.gov (United States)

Lin, Kunning; Ma, Jian; Yuan, Dongxing; Feng, Sichao; Su, Haitao; Huang, Yongming; Shangguan, Qipei

2017-05-15

An integrated system was developed for automatic and sequential determination of NO 2 - , NO 3 - , PO 4 3- , Fe 2+ , Fe 3+ and Mn 2+ in natural waters based on reverse flow injection analysis combined with spectrophotometric detection. The system operation was controlled by a single chip microcomputer and laboratory-programmed software written in LabVIEW. The experimental parameters for each nutrient element analysis were optimized based on a univariate experimental design, and interferences from common ions were evaluated. The upper limits of the linear range (along with detection limit, µmolL -1 ) of the proposed method was 20 (0.03), 200 (0.7), 12 (0.3), 5 (0.03), 5 (0.03), 9 (0.2) µmolL -1 , for NO 2 - , NO 3 - , PO 4 3- , Fe 2+ , Fe 3+ and Mn 2+ , respectively. The relative standard deviations were below 5% (n=9-13) and the recoveries varied from 88.0±1.0% to 104.5±1.0% for spiked water samples. The sample throughput was about 20h -1 . This system has been successfully applied for the determination of multi-nutrient elements in different kinds of water samples and showed good agreement with reference methods (slope 1.0260±0.0043, R 2 =0.9991, n=50). Copyright © 2017 Elsevier B.V. All rights reserved.

Reverse Osmosis

Indian Academy of Sciences (India)

many applications, one of which is desalination of seawater. The inaugural Nobel Prize in Chemistry was awarded in 1901 to van 't Hoff for his seminal work in this area. The present article explains the principle of osmosis and reverse osmosis. Osmosis and Reverse Osmosis. As the name suggests, reverse osmosis is the ...

Advanced Control Synthesis for Reverse Osmosis Water Desalination Processes.

Science.gov (United States)

Phuc, Bui Duc Hong; You, Sam-Sang; Choi, Hyeung-Six; Jeong, Seok-Kwon

2017-11-01

  In this study, robust control synthesis has been applied to a reverse osmosis desalination plant whose product water flow and salinity are chosen as two controlled variables. The reverse osmosis process has been selected to study since it typically uses less energy than thermal distillation. The aim of the robust design is to overcome the limitation of classical controllers in dealing with large parametric uncertainties, external disturbances, sensor noises, and unmodeled process dynamics. The analyzed desalination process is modeled as a multi-input multi-output (MIMO) system with varying parameters. The control system is decoupled using a feed forward decoupling method to reduce the interactions between control channels. Both nominal and perturbed reverse osmosis systems have been analyzed using structured singular values for their stabilities and performances. Simulation results show that the system responses meet all the control requirements against various uncertainties. Finally the reduced order controller provides excellent robust performance, with achieving decoupling, disturbance attenuation, and noise rejection. It can help to reduce the membrane cleanings, increase the robustness against uncertainties, and lower the energy consumption for process monitoring.

Towards an investigation on the determinants for effectiveness and efficiency of reverse logistics systems (RLS

Directory of Open Access Journals (Sweden)

Francisco Gaudêncio Mendonça Freires

2014-01-01

Full Text Available This article deals with the influence of economies of scale and postponement on the efficiency and effectiveness of reverse logistics systems (RLSs. In a global way, it aims to provide an understanding of RLSs to generate knowledge of practical and theoretical character. Starting from a generic model of circular flow of materials, the system studied is positioned between the final consumer and the traditional or direct supply chain. It is a qualitative approach over two case studies carried out in Portugal and Brazil dealing with scraptires. One deals with management system while the other deals with the reverse logistics system. As conclusions, the efficiency of RLSs is aided by economies of scale. Postponement has positive effects on efficiency by increasing the system capacity reducing logistics costs which indirectly leads to economies of scale, having a positive influence on the effectiveness of RLSs. According to what has been stated in this paper, the coordination between the direct and reverse flow is a typical case of a closed circuit.

Reverse flow injection spectrophotometric determination of ciprofloxacin in pharmaceuticals using iron from soil as a green reagent

Science.gov (United States)

Palamy, Sysay; Ruengsitagoon, Wirat

2018-02-01

A novel reverse flow injection spectrophotometric method for the determination of ciprofloxacin was successfully combined with the on-line introduction of an iron solution extracted from soil as green reagent. The assay was optimized by a univariate method to select the optimum conditions for the highest absorbance and highest stability of the complex. Beer-Lambert's law (λmax = 440 nm) is obeyed in the range 0.5-50 μg mL- 1 with a correlation coefficient (r2) of 0.9976 and 0.9996 using soil as green reagent from Khon Kaen, Thailand and Vientiane, Laos, respectively. The average percentage recoveries were in the range of 98.55-102.14% and the precision was in the range of 0.80-1.73%. The limit of detection and the limit of quantitation were 0.20 and 0.69 μg mL- 1, respectively, with a sampling rate of over 46 samples h- 1. The method was successfully applied to the determination of ciprofloxacin in commercial pharmaceutical formulations. The results were in good agreement with those obtained by the reference HPLC method using a t-test at 95% of confidence level for comparison. This method is suitable for laboratories looking for alternative analytical methods using green reagents.

Hydrodynamics of piston-driven laminar pulsating flow: Part 2. Fully developed flow

International Nuclear Information System (INIS)

Aygun, Cemalettin; Aydin, Orhan

2014-01-01

Highlights: • The piston-driven laminar pulsating flow in a pipe is studied. • Fully developed flow is examined analytically, numerically and experimentally. • An increase in F results an increase in the amplitude of the centerline velocity. • The characters of the radial velocity profiles critically depend on both the frequency and the phase angle. • The near/off-wall flow reversals are observed for F = 105, 226 and 402. - Abstract: Piston-driven pulsating flow is a specific type of pressure-driven pulsating flows. In this study, piston-driven laminar pulsating flow in a pipe is studied. This study mainly exists of two parts: developing flow and fully developed flow. In this part, hydrodynamically fully developed flow is examined analytically, numerically and experimentally. A constant value of the time-averaged Reynolds number is considered, Re = 1000. In the theoretical studies, both analytical and numerical, an inlet velocity profile representing the experimental case, i.e., the piston driven flow, is assumed. In the experiments, in the hydrodynamically fully developed region, radial velocity distribution and pressure drop are obtained using hot-wire anemometer and pressure transmitter, respectively. The effect pulsation frequency on the friction coefficient as well as velocity profiles are obtained. A good agreement is observed among analytical, numerical and experimental results

Dependence of the duration of geomagnetic polarity reversals on site latitude.

Science.gov (United States)

Clement, Bradford M

2004-04-08

An important constraint on the processes governing the geodynamo--the flow in the outer core responsible for generating Earth's magnetic field--is the duration of geomagnetic polarity reversals; that is, how long it takes for Earth's magnetic field to reverse. It is generally accepted that Earth's magnetic field strength drops to low levels during polarity reversals, and the field direction progresses through a 180 degrees change while the field is weak. The time it takes for this process to happen, however, remains uncertain, with estimates ranging from a few thousand up to 28,000 years. Here I present an analysis of the available sediment records of the four most recent polarity reversals. These records yield an average estimate of about 7,000 years for the time it takes for the directional change to occur. The variation about this mean duration is not random, but instead varies with site latitude, with shorter durations observed at low-latitude sites, and longer durations observed at mid- to high-latitude sites. Such variation of duration with site latitude is predicted by simple geometrical reversal models, in which non-dipole fields are allowed to persist while the axial dipole decays through zero and then builds in the opposite direction, and provides a constraint on numerical dynamo models.

Airways obstruction in survivors of thoracoplasty: reversibility is greater in non-smokers.

LENUS (Irish Health Repository)

O'Connor, Terence M

2012-02-03

OBJECTIVE: Before the advent of antituberculous chemotherapy, thoracoplasty (TPL) was the definitive form of therapy for cavitary pulmonary tuberculosis. This study aimed to characterize the late functional sequelae of TPL, and to establish the degree of reversibility of any consequent airway obstruction. METHODOLOGY: Pulmonary function was studied in 21 long-term (mean 35 years) survivors of TPL between the years 1990-2001. RESULTS: A mixed obstructive\\/restrictive defect was found in this patient cohort. After inhalation of bronchodilator, marginal increases in FEV(1) and FVC and marginal decreases in FRC, RV and TLC were observed. Maximum mid-expiratory flow rate was severely reduced (28.8% of predicted), but reversibility after inhaled beta(2)-agonist was highest for this parameter of pulmonary function (mean 11%). Smokers had a higher RV (P = 0.04), suggesting hyperinflation, while non-smokers had a larger increase in FEV(1)\\/FVC ratio postbronchodilator (P = 0.004), suggesting more marked reversibility of airways obstruction in this group. CONCLUSIONS: Long-term survivors of TPL have an obstructive as well as a restrictive ventilatory defect. These patients have partial reversibility of the obstructive defect. The degree of reversibility found suggests that bronchodilator therapy may help these patients.

New oral antithrombotics: focus on dabigatran, an oral, reversible direct thrombin inhibitor for the prevention and treatment of venous and arterial thromboembolic disorders

Directory of Open Access Journals (Sweden)

Dahl OE

2012-01-01

Full Text Available Ola E Dahl1,21Department of Orthopaedics, Innlandet Hospital Trust, Elverum Central Hospital, Elverum, Norway; 2Thrombosis Research Institute, London, UKAbstract: Venous thromboembolism, presenting as deep vein thrombosis or pulmonary embolism, is a major challenge for health care systems. It is the third most common vascular disease after coronary heart disease and stroke, and many hospitalized patients have at least one risk factor. In particular, patients undergoing hip or knee replacement are at risk, with an incidence of asymptomatic deep vein thrombosis of 40%–60% without thromboprophylaxis. Venous thromboembolism is associated with significant mortality and morbidity, with patients being at risk of recurrence, post-thrombotic syndrome, and chronic thromboembolic pulmonary hypertension. Arterial thromboembolism is even more frequent, and atrial fibrillation, the most common embolic source (cardiac arrhythmia, is associated with a five-fold increase in the risk of stroke. Strokes due to atrial fibrillation tend to be more severe and disabling and are more often fatal than strokes due to other causes. Currently, recommended management of both venous and arterial thromboembolism involves the use of anticoagulants such as coumarin and heparin derivatives. These agents are effective, although have characteristics that prevent them from providing optimal anticoagulation and convenience. Hence, new improved oral anticoagulants are being investigated. Dabigatran is a reversible, direct thrombin inhibitor, which is administered as dabigatran etexilate, the oral prodrug. Because it is the first new oral anticoagulant that has been licensed in many countries worldwide for thromboprophylaxis following orthopedic surgery and for stroke prevention in patients with atrial fibrillation, this compound will be the main focus of this review. Dabigatran has been investigated for the treatment of established venous thromboembolism and prevention of

Tuning the Stability of Organic Active Materials for Nonaqueous Redox Flow Batteries via Reversible, Electrochemically Mediated Li ⁺ Coordination

Energy Technology Data Exchange (ETDEWEB)

Carino, Emily V.; Staszak-Jirkovsky, Jakub; Assary, Rajeev S.; Curtiss, Larry A.; Markovic, Nenad M.; Brushett, Fikile R.

2016-03-24

We describe an electrochemically mediated interaction between Li+ and a promising active material for nonaqueous redox flow batteries (RFBs), 1,2,3,4-tetrahydro-6,7-dimethoxy-1,1,4,4-tetramethylnaphthalene (TDT), and the impact of this structural interaction on material stability during voltammetric cycling. TDT could be an advantageous organic positive electrolyte material for nonaqueous RFBs due to its high oxidation potential, 4.21 V vs Li/Li⁺, and solubility of at least 1.0 M in select electrolytes. Although results from voltammetry suggest TDT displays Nernstian reversibility in many nonaqueous electrolyte solutions, bulk electrolysis reveals significant degradation in all electrolytes studied, the extent of which depends on the electrolyte solution composition. Results of subtractively normalized in situ Fourier transform infrared spectroscopy (SNIFTIRS) confirm that TDT undergoes reversible structural changes during cyclic voltammetry in propylene carbonate and 1,2-dimethoxyethane solutions containing Li⁺ electrolytes, but irreversible degradation occurs when tetrabutylammonium (TBA+) replaces Li⁺ as the electrolyte cation in these solutions. By combining the results from SNIFTIRS experiments with calculations from density functional theory, solution-phase active species structure and potential-dependent interactions can be determined. We find that Li⁺ coordinates to the Lewis basic methoxy groups of neutral TDT and, upon electrochemical oxidation, this complex dissociates into the radical cation TDT^•+ and Li⁺. The improved cycling stability in the presence of Li⁺ relative to TBA⁺ suggests that the structural interaction reported herein may be advantageous to the design of energy storage materials based on organic molecules.

Reversible S-nitrosylation in an engineered azurin

Energy Technology Data Exchange (ETDEWEB)

Tian, Shiliang; Liu, Jing; Cowley, Ryan E.; Hosseinzadeh, Parisa; Marshall, Nicholas M.; Yu, Yang; Robinson, Howard; Nilges, Mark J.; Blackburn, Ninian J.; Solomon, Edward I.; Lu, Yi

2016-04-25

S-Nitrosothiols are known as reagents for NO storage and transportation and as regulators in many physiological processes. Although the S-nitrosylation catalysed by haem proteins is well known, no direct evidence of S-nitrosylation in copper proteins has been reported. Here, we report reversible insertion of NO into a copper–thiolate bond in an engineered copper centre in Pseudomonas aeruginosa azurin by rational design of the primary coordination sphere and tuning its reduction potential by deleting a hydrogen bond in the secondary coordination sphere. The results not only provide the first direct evidence of S-nitrosylation of Cu(II)-bound cysteine in metalloproteins, but also shed light on the reaction mechanism and structural features responsible for stabilizing the elusive Cu(I)–S(Cys)NO species. The fast, efficient and reversible S-nitrosylation reaction is used to demonstrate its ability to prevent NO inhibition of cytochrome bo3 oxidase activity by competing for NO binding with the native enzyme under physiologically relevant conditions.

Statins prevent cognitive impairment after sepsis by reverting neuroinflammation, and microcirculatory/endothelial dysfunction.

Science.gov (United States)

Reis, Patricia A; Alexandre, Pedro C B; D'Avila, Joana C; Siqueira, Luciana D; Antunes, Barbara; Estato, Vanessa; Tibiriça, Eduardo V; Verdonk, Franck; Sharshar, Tarek; Chrétien, Fabrice; Castro-Faria-Neto, Hugo C; Bozza, Fernando A

2017-02-01

Acute brain dysfunction is a frequent condition in sepsis patients and is associated with increased mortality and long-term neurocognitive consequences. Impaired memory and executive function are common findings in sepsis survivors. Although neuroinflammation and blood-brain barrier dysfunction have been associated with acute brain dysfunction and its consequences, no specific treatments are available that prevent cognitive impairment after sepsis. Experimental sepsis was induced in Swiss Webster mice by intraperitoneal injection of cecal material (5mg/kg, 500μL). Control groups (n=5/group each experiment) received 500μL of saline. Support therapy recover (saline 0.9%, 1mL and imipenem 30mg/kg) were applied (6, 24 and 48h post injection, n=5-10/group, each experiment), together or not with additive orally treatment with statins (atorvastatin/simvastatin 20mg/kg b.w.). Survival rate was monitored at 6, 24 and 48h. In a setting of experiments, animals were euthanized at 6 and 24h after induction for biochemical, immunohistochemistry and intravital analysis. Statins did not prevented mortality in septic mice, however survivors presented lower clinical score. At another setting of experiments, after 15days, mice survivors from fecal supernatant peritoneal sepsis presented cognitive dysfunction for contextual hippocampal and aversive amygdala-dependent memories, which was prevented by atorvastatin/simvastatin treatment. Systemic and brain tissue levels of proinflammatory cytokines/chemokines and activation of microglial were lower in septic mice treated with statins. Brain lipid peroxidation and myeloperoxidase levels were also reduced by statins treatment. Intravital examination of the brain vessels of septic animals revealed decreased functional capillary density and increased rolling and adhesion of leukocytes, and blood flow impairment, which were reversed by treatment with statins. In addition, treatment with statins restored the cholinergic vasodilator response

A new reversible Mg3Ag–H2 system for hydrogen storage

International Nuclear Information System (INIS)

Si, T.Z.; Zhang, J.B.; Liu, D.M.; Zhang, Q.A.

2013-01-01

Highlights: •Mg 3 Ag compound with high-purity was prepared by hydrogen metallurgy. •Mg 3 Ag is first employed for reversible hydrogen storage with altered thermodynamics. •The enhanced cyclic stability is due to the prevention of MgH 2 sintering by MgAg. -- Abstract: For the first time, the compound Mg 3 Ag was employed as a medium for hydrogen storage. It has been demonstrated that the hydriding/dehydriding process of Mg 3 Ag is reversible through the reaction Mg 3 Ag + 2H 2 ↔ 2MgH 2 + MgAg with obtaining altered thermodynamics. An enhanced cycling stability is also achieved by the capacity retention of 95% after 30 cycles, much higher than 70% for the pure Mg sample, which can be explained that the agglomeration and sintering of the resulting MgH 2 are efficiently prevented by the formation of hard and brittle MgAg phase upon multi-cycling

Flow control of micro-ramps on supersonic forward-facing step flow

International Nuclear Information System (INIS)

Zhang Qing-Hu; Zhu Tao; Wu Anping; Yi Shihe

2016-01-01

The effects of the micro-ramps on supersonic turbulent flow over a forward-facing step (FFS) was experimentally investigated in a supersonic low-noise wind tunnel at Mach number 3 using nano-tracer planar laser scattering (NPLS) and particle image velocimetry (PIV) techniques. High spatiotemporal resolution images and velocity fields of supersonic flow over the testing model were captured. The fine structures and their spatial evolutionary characteristics without and with the micro-ramps were revealed and compared. The large-scale structures generated by the micro-ramps can survive the downstream FFS flowfield. The micro-ramps control on the flow separation and the separation shock unsteadiness was investigated by PIV results. With the micro-ramps, the reduction in the range of the reversal flow zone in streamwise direction is 50% and the turbulence intensity is also reduced. Moreover, the reduction in the average separated region and in separation shock unsteadiness are 47% and 26%, respectively. The results indicate that the micro-ramps are effective in reducing the flow separation and the separation shock unsteadiness. (paper)

Abatement of fluorinated compounds using a 2.45 GHz microwave plasma torch with a reverse vortex plasma reactor

Energy Technology Data Exchange (ETDEWEB)

Kim, J.H.; Cho, C.H.; Shin, D.H. [Plasma Technology Research Center, National Fusion Research Institute, 814-2 Oxikdo-dong, Gunsan-city, Jeollabuk-do (Korea, Republic of); Hong, Y.C., E-mail: ychong@nfri.re.kr [Plasma Technology Research Center, National Fusion Research Institute, 814-2 Oxikdo-dong, Gunsan-city, Jeollabuk-do (Korea, Republic of); Shin, Y.W. [Plasma Technology Research Center, National Fusion Research Institute, 814-2 Oxikdo-dong, Gunsan-city, Jeollabuk-do (Korea, Republic of); School of Advanced Green Energy and Environments, Handong Global University, Heunghae-eup, Buk-gu, Pohang-city, Gyeongbuk (Korea, Republic of)

2015-08-30

Highlights: • We developed a microwave plasma torch with reverse vortex reactor (RVR). • We calculated a volume fraction and temperature distribution of discharge gas and waste. • The performance of reverse vortex reactor increased from 29% to 43% than conventional vortex reactor. - Abstract: Abatement of fluorinated compounds (FCs) used in semiconductor and display industries has received an attention due to the increasingly stricter regulation on their emission. We have developed a 2.45 GHz microwave plasma torch with reverse vortex reactor (RVR). In order to design a reverse vortex plasma reactor, we calculated a volume fraction and temperature distribution of discharge gas and waste gas in RVR by ANSYS CFX of computational fluid dynamics (CFD) simulation code. Abatement experiments have been performed with respect to SF{sub 6}, NF{sub 3} by varying plasma power and N{sub 2} flow rates, and FCs concentration. Detailed experiments were conducted on the abatement of NF{sub 3} and SF{sub 6} in terms of destruction and removal efficiency (DRE) using Fourier transform infrared (FTIR). The DRE of 99.9% for NF{sub 3} was achieved without an additive gas at the N{sub 2} flow rate of 150 liter per minute (L/min) by applying a microwave power of 6 kW with RVR. Also, a DRE of SF{sub 6} was 99.99% at the N{sub 2} flow rate of 60 L/min using an applied microwave power of 6 kW. The performance of reverse vortex reactor increased about 43% of NF{sub 3} and 29% of SF{sub 6} abatements results definition by decomposition energy per liter more than conventional vortex reactor.

Modeling the Hybrid Flow Shop Scheduling Problem Followed by an Assembly Stage Considering Aging Effects and Preventive Maintenance Activities

Directory of Open Access Journals (Sweden)

Seyyed Mohammad Hassan Hosseini

2016-05-01

Full Text Available Scheduling problem for the hybrid flow shop scheduling problem (HFSP followed by an assembly stage considering aging effects additional preventive and maintenance activities is studied in this paper. In this production system, a number of products of different kinds are produced. Each product is assembled with a set of several parts. The first stage is a hybrid flow shop to produce parts. All machines can process all kinds of parts in this stage but each machine can process only one part at the same time. The second stage is a single assembly machine or a single assembly team of workers. The aim is to schedule the parts on the machines and assembly sequence and also determine when the preventive maintenance activities get done in order to minimize the completion time of all products (makespan. A mathematical modeling is presented and its validation is shown by solving an example in small scale. Since this problem has been proved strongly NP-hard, in order to solve the problem in medium and large scale, four heuristic algorithms is proposed based on the Johnson’s algorithm. The numerical experiments are used to run the mathematical model and evaluate the performance of the proposed algorithms.

The Effect of Pitching Phase on the Vortex Circulation for a Flapping Wing During Stroke Reversal

Science.gov (United States)

Burge, Matthew; Ringuette, Matthew

2017-11-01

We study the effect of pitching-phase on the circulation behavior for the 3D flow structures produced during stroke reversal for a 2-degree-of-freedom flapping wing executing hovering kinematics. Previous research has related the choice in pitching-phase with respect to the wing rotation during stroke reversal (advanced vs. symmetric pitch-timing) to a lift peak preceding stroke reversal. However, results from experiments on the time-varying circulation contributions from the 3D vortex structures across the span produced by both rotation and pitching are lacking. The objective of this research is to quantitatively examine how the spanwise circulation of these structures is affected by the pitching-phase for several reduced pitching frequencies. We employ a scaled wing model in a glycerin-water mixture and measure the time-varying velocity using multiple planes of stereo digital particle image velocimetry. Data-plane positions along the wing span are informed by the unsteady behavior of the 3D vortex structures found in our prior flow visualization movies. Individual vortices are identified to calculate their circulation. This work is aimed at understanding how the behavior of the vortex structures created during stroke reversal vary with key motion parameters. This work is supported by the National Science Foundation, Award Number 1336548, supervised by Dr. Ronald Joslin.

Social stakes of the reversibility in the deep storage of high level radioactive wastes

International Nuclear Information System (INIS)

Heriard-Dubreuil, G.; Schieber, C.; Schneider, T.

1998-06-01

This document proposes a study of the conditions which surrounded the reversibility introduction in high activity wastes deep storage at an international scale, as well as a reflexion on the social stakes associated there. In France, the law of december 30, 1991 concerning the research on the radioactive wastes prescribes '' the study of possibilities retrieval or non retrieval storage in deep geological deposits''. The analysis of the reversibility associated social stakes emphasizes the necessity to prevent irreversible consequences, to take care to the choices reversibility, to preserve the future generations autonomy. Thus to elaborate a more satisfactory solution between deep disposal and surface storage, a deep storage, capable of gradually evolution, concept is defined. (A.L.B.)

Vertical pump with free floating check valve

International Nuclear Information System (INIS)

Lindsay, M.

1980-01-01

A vertical pump is described which has a bottom discharge with a free floating check valve disposed in the outlet plenum thereof. The free floating check valve comprises a spherical member with a hemispherical cage-like member attached thereto which is capable of allowing forward or reverse flow under appropriate conditions while preventing reverse flow under inappropriate conditions

Large-eddy simulations of the non-reactive flow in the Sydney swirl burner

DEFF Research Database (Denmark)

Yang, Yang; Kær, Søren Knudsen

2012-01-01

results. In medium swirling case, there are two reverse-flow regions with a collar-like structure between them. The existence of strong unsteady structure, precessing vortex core, was proven. Coherent structures are detached from the instantaneous field. Q-criterion was used to visualize vorticity field...... with distinct clear structure of vortice tubes. Dominating spatial–temporal structures contained in different cross sections were extracted using proper orthogonal decomposition. In high swirling case, there is only one long reverse-flow region. In this paper, we proved the capability of a commercial CFD...... package in predicting complex flow field and presented the potential of large eddy simulation in understanding dynamics....

Coding/decoding and reversibility of droplet trains in microfluidic networks.

Science.gov (United States)

Fuerstman, Michael J; Garstecki, Piotr; Whitesides, George M

2007-02-09

Droplets of one liquid suspended in a second, immiscible liquid move through a microfluidic device in which a channel splits into two branches that reconnect downstream. The droplets choose a path based on the number of droplets that occupy each branch. The interaction among droplets in the channels results in complex sequences of path selection. The linearity of the flow through the microchannels, however, ensures that the behavior of the system can be reversed. This reversibility makes it possible to encrypt and decrypt signals coded in the intervals between droplets. The encoding/decoding device is a functional microfluidic system that requires droplets to navigate a network in a precise manner without the use of valves, switches, or other means of external control.

N-Acetylcysteine Reverses Cocaine Induced Metaplasticity

Science.gov (United States)

Moussawi, Khaled; Pacchioni, Alejandra; Moran, Megan; Olive, M. Foster; Gass, Justin T.; Lavin, Antonieta; Kalivas, Peter W

2009-01-01

Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in cortico-accumbens circuitry critical for regulating motivated behavior. RWe found that rats withdrawn from cocaine self-administration had a marked in vivo deficit in the ability to develop long-term potentation (LTP) and depression (LTD) in the nucleus accumbens core subregion following stimulation of prefrontal cortex. N-acetylcysteine treatment prevents relapse in animal models and craving in humans by activating cystine-glutamate exchange and thereby stimulating extrasynaptic metabotropic glutamate receptors (mGluR). N-acetylcysteine treatment restored the ability to induce LTP and LTD by indirectly stimulating mGluR2/3 and mGluR5, respectively. Cocaine self-administration induces metaplasticity that inhibits the further induction of synaptic plasticity, and this impairment can be reversed by N-acetylcysteine, a drug that also prevents relapse. PMID:19136971

N-Acetylcysteine reverses cocaine-induced metaplasticity.

Science.gov (United States)

Moussawi, Khaled; Pacchioni, Alejandra; Moran, Megan; Olive, M Foster; Gass, Justin T; Lavin, Antonieta; Kalivas, Peter W

2009-02-01

Cocaine addiction is characterized by an impaired ability to develop adaptive behaviors that can compete with cocaine seeking, implying a deficit in the ability to induce plasticity in cortico-accumbens circuitry crucial for regulating motivated behavior. We found that rats withdrawn from cocaine self-administration had a marked in vivo deficit in the ability to develop long-term potentiation (LTP) and long-term depression (LTD) in the nucleus accumbens core subregion after stimulation of the prefrontal cortex. N-acetylcysteine (NAC) treatment prevents relapse in animal models and craving in humans by activating cystine-glutamate exchange and thereby stimulating extrasynaptic metabotropic glutamate receptors (mGluR). NAC treatment of rats restored the ability to induce LTP and LTD by indirectly stimulating mGluR2/3 and mGluR5, respectively. Our findings show that cocaine self-administration induces metaplasticity that inhibits further induction of synaptic plasticity, and this impairment can be reversed by NAC, a drug that also prevents relapse.

Batteryless photovoltaic reverse-osmosis desalination system

Energy Technology Data Exchange (ETDEWEB)

Thomson, M.; Miranda, M.; Gwillim, J.; Rowbottom, A.; Draisey, I.

2001-07-01

The aim of this project was to design an efficient cost-effective batteryless photovoltaic-powered seawater reverse-osmosis desalination system, to deliver in the order of 3 m{sup 3} of fresh drinking water per day. The desalination of seawater to produce fresh drinking water is extremely valuable on islands and in coastal regions wherever natural freshwater is scarce. Existing small-scale desalination equipment, suitable for areas of medium and low population density, often requires a copious and constant supply of energy, either electricity or diesel. If supply of these fuels is expensive or insecure, but the area has a good solar resource, the use of photovoltaic power is an attractive option. Existing demonstrations of photovoltaic-powered desalination generally employ lead-acid batteries, which allow the equipment to operate at a constant flow, but are notoriously problematic in practice. The system developed in this project runs at variable flow, enabling it to make efficient use of the naturally varying solar resource, without need of batteries. In a sense, the freshwater tank is providing the energy storage. In this project, we have reviewed the merits of a wide variety of reverse-osmosis system configurations and component options. We have completed extensive in-house testing and characterisation of major hardware components and used the results to construct detailed software models. Using these, we have designed a system that meets the above project aim, and we have predicted its performance in detail. Our designs show that a system costing 23,055 pounds stirling will produce 1424 m{sup 3} of fresh drinking water annually - an average of just over 3.9 m{sup 3}/day. The system has no fuel costs and no batteries. The overall cost of water, including full maintenance, is 2.00 pounds stirling per m{sup 3}. The energy consumption (photovoltaic-electricity) is typically between 3.2 and 3.7 kWh/m{sup 3} depending on the solar irradiance and feed water

Association of Live Donor Nephrectomy and Reversal of Renal Artery Spasm

Directory of Open Access Journals (Sweden)

Jalal Azmandian

2014-01-01

Full Text Available Background: Kidney transplantation is the best treatment option for kidney failure. Major medical progress has been made in the field of renal transplantation over the last 40 years. The surgical procedure has been standardized and the complication rate is low. Overall, the outcome of renal transplantation is excellent and has improved over time. Vascular complications after renal transplantation are the most frequent type of complication following urological complications. Renal artery spasm (RAS following manipulation of renal artery is a common problem during live donor nephrectomy (LDN. The aim of this study was to determine whether or not it is necessary to wait for reverse of RAS and resumption of urinary flow before nephrectomy. Materials and Methods: In this clinical trial 16 cases of LDN who developed RAS during surgery received intra-arterial injection of 40 mg papaverine. In 8 cases surgery continued towards nephrectomy and in other 8 cases we waited for reverse of RAS. All analyses were performed using SPSS-11. Results: In both groups urinary flow started a few minutes (Mean, 12 min after declamping of transplanted kidney and normal renal consistency and color were achieved. There was no significant difference between urinary volume during 12 h after transplantation in two groups. Conclusion: The results showed that it might not be necessary to wait for reverse of RAS before LDN. Both patient (less anesthesia complications and hospital (less expenses will benefit from this time saving.

Microbial electrosynthesis of hydrogen peroxide in microbial reverse-electrodialysis electrolysis cell

DEFF Research Database (Denmark)

Li, Xiaohu; Angelidaki, Irini; Zhang, Yifeng

2016-01-01

Microbial reverse-electrodialysis electrolysis cell (MREC) as a novel type of microbial electrochemical technologies has been proposed to produce H2 and CH4. In this study, we developed MREC to produce the strong oxidant H2O2. In the MREC, electrical potential generated by the exoelectrogens...... and the salinity-gradient between sea water and river water were utilized to drive the high-rate H2O2 production without external power supply. Operational parameters such as air flow rate, pH, cathodic potential, flow rate of high and low concentration solution were investigated. The optimal H2O2 production were...

Flame stabilization and mixing characteristics in a Stagnation Point Reverse Flow combustor

Science.gov (United States)

Bobba, Mohan K.

A novel combustor design, referred to as the Stagnation Point Reverse-Flow (SPRF) combustor, was recently developed that is able to operate stably at very lean fuel-air mixtures and with low NOx emissions even when the fuel and air are not premixed before entering the combustor. The primary objective of this work is to elucidate the underlying physics behind the excellent stability and emissions performance of the SPRF combustor. The approach is to experimentally characterize velocities, species mixing, heat release and flame structure in an atmospheric pressure SPRF combustor with the help of various optical diagnostic techniques: OH PLIF, chemiluminescence imaging, PIV and Spontaneous Raman Scattering. Results indicate that the combustor is primarily stabilized in a region downstream of the injector that is characterized by low average velocities and high turbulence levels; this is also the region where most of the heat release occurs. High turbulence levels in the shear layer lead to increased product entrainment levels, elevating the reaction rates and thereby enhancing the combustor stability. The effect of product entrainment on chemical timescales and the flame structure is illustrated with simple reactor models. Although reactants are found to burn in a highly preheated (1300 K) and turbulent environment due to mixing with hot product gases, the residence times are sufficiently long compared to the ignition timescales such that the reactants do not autoignite. Turbulent flame structure analysis indicates that the flame is primarily in the thin reaction zones regime throughout the combustor, and it tends to become more flamelet like with increasing distance from the injector. Fuel-air mixing measurements in case of non-premixed operation indicate that the fuel is shielded from hot products until it is fully mixed with air, providing nearly premixed performance without the safety issues associated with premixing. The reduction in NOx emissions in the SPRF

Improving the reverse recovery of power MOSFET integral diodes by electron irradiation

International Nuclear Information System (INIS)

Baliga, B.J.; Walden, J.P.

1983-01-01

Using 3 MeV electron irradiation at room temperature it was found that the reverse recovery charge in the integral diode could be continuously reduced in a well controlled manner from over 500nC to less than 100nC without any significant increase in the forward voltage drop of the integral diode under typical operating peak currents. The reverse recovery time was also observed to decrease from 3 microseconds to less than 200 nsec when the radiation dose was increased from 0 to 16 Megarads. The damage produced in gate oxide of the MOSFET due to the electron radiation damage was found to cause an undesirable decrease in the gate threshold voltage. This resulted in excessive channel leakage current flow in the MOSFET at zero gate bias. It was found that this channel leakage current was substantially reduced by annealing the devices at 140 0 C without influencing the integral diode reverse recovery speed. Thus, the electron irradiation technique was found to be effective in controlling the integral diode reverse recovery characteristics without any degradation of the power MOSFET characteristics. (author)

Simultaneous and spontaneous reversal of positional nystagmus; an unusual peripheral sign of benign paroxysmal positional vertigo

Directory of Open Access Journals (Sweden)

Sertac Yetiser, MD

2017-06-01

Full Text Available Direction-changing positional nystagmus is generally thought to be of central origin. Reversal of initial positional nystagmus during maintaining the head position in patients with benign paroxysmal positional vertigo (BPPV is quite unusual and could be a sign of peripheral pathology. Vestibular reflex adaptation, simultaneous co-existence of canalolithiasis and cupulolithiasis in the same or both ears and changing in direction of debris movement have been proposed for the mechanism of this phenomenon. This can be a sign of simultaneous ampullopedal and ampulofugal flows during single head movement. This double-phase pattern of flow causing reversal of positional nystagmus could be related with the amount, location and dispersal of otolithic debris inside the membranous labyrinth. Four patients (3 lateral canal canalolithiasis and 1 posterior canal with reversing spontaneous nystagmus among 530 patients with BPPV have been identified in our clinic. They have been cured with standard re-positioning maneuvers. Endolymphatic reflux theory has been proposed as the underlying mechanism for unusual behavior of otolithic debris.

Inactivation of Ca2+-induced ciliary reversal by high-salt extraction in the cilia of Paramecium.

Science.gov (United States)

Kutomi, Osamu; Seki, Makoto; Nakamura, Shogo; Kamachi, Hiroyuki; Noguchi, Munenori

2013-10-01

Intracellular Ca(2+) induces ciliary reversal and backward swimming in Paramecium. However, it is not known how the Ca(2+) signal controls the motor machinery to induce ciliary reversal. We found that demembranated cilia on the ciliated cortical sheets from Paramecium caudatum lost the ability to undergo ciliary reversal after brief extraction with a solution containing 0.5 M KCl. KNO(3), which is similar to KCl with respect to chaotropic effect; it had the same effect as that of KCl on ciliary response. Cyclic AMP antagonizes Ca(2+)-induced ciliary reversal. Limited trypsin digestion prevents endogenous A-kinase and cAMP-dependent phosphorylation of an outer arm dynein light chain and induces ciliary reversal. However, the trypsin digestion prior to the high-salt extraction did not affect the inhibition of Ca(2+)-induced ciliary reversal caused by the high-salt extraction. Furthermore, during the course of the high-salt extraction, some axonemal proteins were extracted from ciliary axonemes, suggesting that they may be responsible for Ca(2+)-induced ciliary reversal.

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

Science.gov (United States)

Sukoff Rizzo, Stacey J; Pulicicchio, Claudine; Malberg, Jessica E; Andree, Terrance H; Stack, Gary P; Hughes, Zoë A; Schechter, Lee E; Rosenzweig-Lipson, Sharon

2009-09-01

Sexual dysfunction associated with antidepressant treatment continues to be a major compliance issue for antidepressant therapies. 5-HT(1A) antagonists have been suggested as beneficial adjunctive treatment in respect of antidepressant efficacy; however, the effects of 5-HT(1A) antagonism on antidepressant-induced side-effects has not been fully examined. The present study was conducted to evaluate the ability of acute or chronic treatment with 5-HT(1A) antagonists to alter chronic fluoxetine-induced impairments in sexual function. Chronic 14-d treatment with fluoxetine resulted in a marked reduction in the number of non-contact penile erections in sexually experienced male rats, relative to vehicle-treated controls. Acute administration of the 5-HT(1A) antagonist WAY-101405 resulted in a complete reversal of chronic fluoxetine-induced deficits on non-contact penile erections at doses that did not significantly alter baselines. Chronic co-administration of the 5-HT(1A) antagonists WAY-100635 or WAY-101405 with fluoxetine prevented fluoxetine-induced deficits in non-contact penile erections in sexually experienced male rats. Moreover, withdrawal of WAY-100635 from co-treatment with chonic fluoxetine, resulted in a time-dependent reinstatement of chronic fluoxetine-induced deficits in non-contact penile erections. Additionally, chronic administration of SSA-426, a molecule with dual activity as both a SSRI and 5-HT(1A) antagonist, did not produce deficits in non-contact penile erections at doses demonstrated to have antidepressant-like activity in the olfactory bulbectomy model. Taken together, these data suggest that 5-HT(1A) antagonist treatment may have utility for the management of SSRI-induced sexual dysfunction.

Derivatives and Global Capital Flows: Applications to Asia

OpenAIRE

J. A. Kregel

1998-01-01

There are four factors involved in the current financial crisis in Asia that have caused surprise. Since the Latin American debt crisis was thought to have been aggravated by the dominance of syndicated private bank lending, borrowers were encouraged to increase private direct investment flows. The stability of capital flows to Asia was used as an example. Yet, the Asian crisis appears to have been precipitated by the reversal of short-term private bank lending. Second, the flows of capital t...

Quickly erupted volcanic sections of the Steens Basalt, Columbia River Basalt Group: Secular variation, tectonic rotation, and the Steens Mountain reversal

Science.gov (United States)

Jarboe, Nicholas A.; Coe, Robert S.; Renne, Paul R.; Glen, Jonathan M. G.; Mankinen, Edward A.

2008-01-01

The Steens Basalt, now considered part of the Columbia River Basalt Group (CRBG), contains the earliest eruptions of this magmatic episode. Lava flows of the Steens Basalt cover about 50,000 km2 of the Oregon Plateau in sections up to 1000 m thick. The large number of continuously exposed, quickly erupted lava flows (some sections contain over 200 flows) allows for small loops in the magnetic field direction paths to be detected. For volcanic rocks, this detail and fidelity are rarely found outside of the Holocene and yield estimates of eruption durations at our four sections of ∼2.5 ka for 260 m at Pueblo Mountains, 0.5 to 1.5 ka for 190 m at Summit Springs, 1–3 ka for 170 m at North Mickey, and ∼3 ka for 160 m at Guano Rim. That only one reversal of the geomagnetic field occurred during the eruption of the Steens Basalt (the Steens reversal at approximately 16.6 Ma) is supported by comparing 40Ar/39Ar ages and magnetic polarities to the geomagnetic polarity timescale. At Summit Springs two 40Ar/39Ar ages from normal polarity flows (16.72 ± ± 0.29 Ma (16.61) and 16.92 ± ± 0.52 Ma (16.82); ± ± equals 2σ error) place their eruptions after the Steens reversal, while at Pueblo Mountains an 40Ar/39Ar age of 16.72 ± ± 0.21 Ma (16.61) from a reverse polarity flow places its eruption before the Steens reversal. Paleomagnetic field directions yielded 50 nontransitional directional-group poles which, combined with 26 from Steens Mountain, provide a paleomagnetic pole for the Oregon Plateau of 85.7°N, 318.4°E, K = 15.1, A95 = 4.3. Comparison of this new pole with a reference pole derived from CRBG flows from eastern Washington and a synthetic reference pole for North America derived from global data implies relative clockwise rotation of the Oregon Plateau of 7.4 ± 5.0° or 14.5 ± 5.4°, respectively, probably due to northward decreasing extension of the basin and range.

LES of hypersonic flow over a 3D single-fin

OpenAIRE

Fang, J.; Yao, Y.; Lu, L.; Zheng, Y.

2015-01-01

LES of hypersonic flow passing a 3D single-fin at Mach 5 and Re∞=3.7×107/m was conducted using a newly developed 7th-order low-dissipation monotonicity-preserving NS solver with dynamic Smagorinsky subgrid model. The simulation captures salient flow phenome such as shock systems, flow separation structures, and turbulence characteristics. It was found that in the reverse flow region, the streamwise elongated coherent structures are regenerated beneath the main separation vortex, almost immedi...

Eye wash water flow direction study: an evaluation of the effectiveness of eye wash devices with opposite directional water flow

OpenAIRE

Fogt JS; Jones-Jordan LA; Barr JT

2018-01-01

Jennifer S Fogt, Lisa A Jones-Jordan, Joseph T Barr The Ohio State University College of Optometry, Columbus, OH, USA Introduction: New designs of eye wash stations have been developed in which the direction of water flow from the fountain has been reversed, with two water streams originating nasally in both eyes and flowing toward the temporal side of each eye. No study has been done to determine the ideal direction of water flow coming from the eye wash in relation to the eye. Materials ...

Dynamic alteration of regional cerebral blood flow during carotid compression and proof of reversibility

International Nuclear Information System (INIS)

Asahi, Kouichi; Hori, M; Hamasaki, N; Sato, S; Nakanishi, H; Kuwatsuru, R; Sasai, K; Aoki, S

2012-01-01

It is difficult to non-invasively visualize changes in regional cerebral blood flow caused by manual compression of the carotid artery. To visualize dynamic changes in regional cerebral blood flow during and after manual compression of the carotid artery. Two healthy volunteers were recruited. Anatomic features and flow directions in the circle of Willis were evaluated with time-of-flight magnetic resonance angiography (MRA) and two-dimensional phase-contrast (2DPC) MRA, respectively. Regional cerebral blood flow was visualized with territorial arterial spin-labeling magnetic resonance imaging (TASL-MRI). TASL-MRI and 2DPC-MRA were performed in three states: at rest, during manual compression of the right carotid artery, and after decompression. In one volunteer, time-space labeling inversion pulse (Time-SLIP) MRA was performed to confirm collateral flow. During manual carotid compression, in one volunteer, the right thalamus changed to be fed only by the vertebrobasilar system, and the right basal ganglia changed to be fed by the left internal carotid artery. In the other volunteer, the right basal ganglia changed to be fed by the vertebrobasilar system. 2DPC-MRA showed that the flow direction changed in the right A1 segment of the anterior cerebral artery and the right posterior communicating artery. Perfusion patterns and flow directions recovered after decompression. Time-SLIP MRA showed pial vessels and dural collateral circulation when the right carotid artery was manually compressed. Use of TASL-MRI and 2DPC-MRA was successful for non-invasive visualization of the dynamic changes in regional cerebral blood flow during and after manual carotid compression

Barriers and Prospects for Reverse Logistics as Regards oil Lube and its Packaging

Directory of Open Access Journals (Sweden)

Luis Alfredo Sencovici

2015-08-01

Full Text Available This article aims to discuss the main challenges and prospects for the implementation of reverse logistics to lube oil and its packaging. The methodology focuses on conducting in-depth interviews with representatives of these products’ chains, and the results show that technological advances now allow for the generation of re-refined oil with better economic and environmental features than crude oil, and there have been noticeable advances as to packaging too. However, issues such as conflicts in the reverse chain as to the distribution costs of collection, lack of regional solutions to recycling activities, poor supervision, lack of tax incentives and manufacturers’ low interest in modify their products and processes emphasis on prevention challenge the expansion of large-scale reverse logistics activity in the country.

How to use your peak flow meter

Science.gov (United States)

... meter - how to use; Asthma - peak flow meter; Reactive airway disease - peak flow meter; Bronchial asthma - peak ... 2014:chap 55. National Asthma Education and Prevention Program website. How to use a peak flow meter. ...

Sheared flow layer formation in tokamak plasmas with reversed magnetic shear

International Nuclear Information System (INIS)

Dong, J.Q.; Long, Y.X.; Mou, Z.Z.; Zhang, J.H.; Li, J.Q.

2005-01-01

Sheared flow layer (SFL) formation due to magnetic energy release through tearing-reconnections in tokamak plasmas is investigated. The characteristics of the SFLs created in the development of double tearing mode, mediated by electron viscosity in configurations with non-monotonic safety factor q profiles and, therefore, two rational flux surfaces of same q value, are analyzed in detail as an example. Quasi-linear simulations demonstrate that the sheared flows induced by the mode have desirable characteristics (lying at the boundaries of the magnetic islands), and sufficient levels required for internal transport barrier (ITB) formation. A possible correlation of the SFLs with experimental observations, that double transport barrier structures are preferentially formed in proximity of the two rational surfaces, is also proffered. (author)

Determination of Diffusion Coefficients and Activation Energy of Selected Organic Liquids using Reversed-Flow Gas Chromatographic Technique

International Nuclear Information System (INIS)

Khalisanni Khalid; Rashid Atta Khan; Sharifuddin Mohd Zain

2012-01-01

Evaporation of vaporize organic liquid has ecological consequences when the compounds are introduced into both freshwater and marine environments through industrial effluents, or introduced directly into the air from industrial unit processes such as bioreactors and cooling towers. In such cases, a rapid and simple method are needed to measure physicochemical properties of the organic liquids. The Reversed-Flow Gas Chromatography (RF-GC) sampling technique is an easy, fast and accurate procedure. It was used to measure the diffusion coefficients of vapors from liquid into a carrier gas and at the same time to determine the rate coefficients for the evaporation of the respective liquid. The mathematical expression describing the elution curves of the samples peaks was derived and used to calculate the respective parameters for the selected liquid pollutants selected such as methanol, ethanol, 1-propanol, 1-butanol, n-pentane, n-hexane, n-heptane and n-hexadecane, evaporating into the carrier gas of nitrogen. The values of diffusion coefficients found were compared with those calculated theoretically or reported in the literature. The values of evaporation rate were used to determine the activation energy of respective samples using Arrhenius equation. An interesting finding of this work is by using an alternative mathematical analysis based on equilibrium at the liquid-gas interphase, the comparison leads to profound agreement between theoretical values of diffusion coefficients and experimental evidence. (author)

CO2 saturated water as two-phase flow for fouling control in reverse electrodialysis

NARCIS (Netherlands)

Moreno, J.; de Hart, N.; Saakes, M.; Nijmeijer, K.

2017-01-01

When natural feed waters are used in the operation of a reverse electrodialysis (RED) stack, severe fouling on the ion exchange membranes and spacers occurs. Fouling of the RED stack has a strong influence on the gross power density output; which can decrease up to 50%. Moreover, an increase in the

Implementation of all-optical reversible logic gate based on holographic laser induced grating using azo-dye doped polymers

Science.gov (United States)

Forsati, Rana; Valipour Ebrahimi, Sara; Navi, Keivan; Mohajerani, Ezeddin; Jashnsaz, Hossein

2013-02-01

Increasing demand for power reduction in computer systems has led to new trends in computations and computer design including reversible computing. Its main aim is to eliminate power dissipation in logical elements but can have some other advantages such as data security and error prevention. Because of interesting properties of reversible computing, implementing computing devices with reversible manner is the only way to make the reversible computing a reality. In recent years, reversible logic has turned out to be a promising computing paradigm having application in CMOS, nanotechnology, quantum computing and optical computing. In this paper, we propose and realize a novel implementation of Toffoli gate in all-optical domain. We have explained its principle of operations and described an actual experimental implementation. The all-optical reversible gate presented in this paper will be useful in different applications such as arithmetic and logical operations in the domain of reversible logic-based computing.

Reconstruction of hand contracture by reverse ulnar perforator flap

Directory of Open Access Journals (Sweden)

Cengiz Eser

2016-04-01

Full Text Available Hand burn scar contractures affect patients in aesthetic and functional aspects. After releasing these scars, the defects should be repaired. The reconstruction methods include primary suturation, Z plasty, skin grafting, local or free flaps, etc. All methods have their own advantages and disadvantages. One of the most useful flaps is the reverse ulnar perforator flap. We performed a two-staged procedure for repairing a post-burn contracture release defect in a 40-year-old male. In the first stage we applied reverse ulnar perforator flap for the hand defect, and ulnar artery and vein repair in the second stage. In conclusion, this two-staged procedure is a non-primary but useful option for hand and finger defects and prevents major vascular structure damage of the forearm. [Hand Microsurg 2016; 5(1.000: 40-43

Flow regimes and mechanistic modeling of critical heat flux under subcooled flow boiling conditions

Science.gov (United States)

Le Corre, Jean-Marie

Thermal performance of heat flux controlled boiling heat exchangers are usually limited by the Critical Heat Flux (CHF) above which the heat transfer degrades quickly, possibly leading to heater overheating and destruction. In an effort to better understand the phenomena, a literature review of CHF experimental visualizations under subcooled flow boiling conditions was performed and systematically analyzed. Three major types of CHF flow regimes were identified (bubbly, vapor clot and slug flow regime) and a CHF flow regime map was developed, based on a dimensional analysis of the phenomena and available data. It was found that for similar geometric characteristics and pressure, a Weber number (We)/thermodynamic quality (x) map can be used to predict the CHF flow regime. Based on the experimental observations and the review of the available CHF mechanistic models under subcooled flow boiling conditions, hypothetical CHF mechanisms were selected for each CHF flow regime, all based on a concept of wall dry spot overheating, rewetting prevention and subsequent dry spot spreading. It is postulated that a high local wall superheat occurs locally in a dry area of the heated wall, due to a cyclical event inherent to the considered CHF two-phase flow regime, preventing rewetting (Leidenfrost effect). The selected modeling concept has the potential to span the CHF conditions from highly subcooled bubbly flow to early stage of annular flow. A numerical model using a two-dimensional transient thermal analysis of the heater undergoing nucleation was developed to mechanistically predict CHF in the case of a bubbly flow regime. In this type of CHF two-phase flow regime, the high local wall superheat occurs underneath a nucleating bubble at the time of bubble departure. The model simulates the spatial and temporal heater temperature variations during nucleation at the wall, accounting for the stochastic nature of the boiling phenomena. The model has also the potential to evaluate

Field reversal produced by a plasma gun

International Nuclear Information System (INIS)

Hartman, C.W.; Condit, W.; Granneman, E.H.A.; Prono, D.; Smith, A.C. Jr.; Taska, J.; Turner, W.C.

1980-01-01

Experimental results are presented of the production of Field-Reversed Plasma with a high energy coaxial plasma gun. The gun is magnetized with solenoids inside the center electrode and outside the outer electrode so that plasma emerging from the gun entrains the radial fringer field at the muzzle. The plasma flow extends field lines propagating a high electrical conductivity, the flux inside the center electrode should be preserved. However, for low flux, the trapped flux exceeds by 2 or more the initial flux, possibly because of helical deformation of the current channel extending from the center electrode

Reverse genetics with animal viruses. NSV reverse genetics

International Nuclear Information System (INIS)

Mebatsion, T.

2005-01-01

New strategies to genetically manipulate the genomes of several important animal pathogens have been established in recent years. This article focuses on the reverse genetics techniques, which enables genetic manipulation of the genomes of non-segmented negative-sense RNA viruses. Recovery of a negative-sense RNA virus entirely from cDNA was first achieved for rabies virus in 1994. Since then, reverse genetic systems have been established for several pathogens of medical and veterinary importance. Based on the reverse genetics technique, it is now possible to design safe and more effective live attenuated vaccines against important viral agents. In addition, genetically tagged recombinant viruses can be designed to facilitate serological differentiation of vaccinated animals from infected animals. The approach of delivering protective immunogens of different pathogens using a single vector was made possible with the introduction of the reverse genetics system, and these novel broad-spectrum vaccine vectors have potential applications in improving animal health in developing countries. (author)

Seasonally reversing current bands across 15 degrees N in the Arabian Sea and their implications

Digital Repository Service at National Institute of Oceanography (India)

Antony, M.K.; Shenoi, S.S.C.; Gopalakrishna, V.V.; Murty, C.S.; Rao, D.P.; Murty, V.S.N.; Sastry, J.S.

Geostrophic currents computed from hydrographic data collected in different months from a section along 15 degrees N in the Arabian Sea show alternate N-S current bands. Flow directions of these bands are found to reverse with the change in season...

Influence of Auroral Streamers on Rapid Evolution of Ionospheric SAPS Flows

Science.gov (United States)

Gallardo-Lacourt, Bea; Nishimura, Y.; Lyons, L. R.; Mishin, E. V.; Ruohoniemi, J. M.; Donovan, E. F.; Angelopoulos, V.; Nishitani, N.

2017-12-01

Subauroral polarization streams (SAPS) often show large, rapid enhancements above their slowly varying component. We present simultaneous observations from ground-based all-sky imagers and flows from the Super Dual Auroral Radar Network radars to investigate the relationship between auroral phenomena and flow enhancement. We first identified auroral streamers approaching the equatorward boundary of the auroral oval to examine how often the subauroral flow increased. We also performed the reverse query starting with subauroral flow enhancements and then evaluated the auroral conditions. In the forward study, 98% of the streamers approaching the equatorward boundary were associated with SAPS flow enhancements reaching 700 m/s and typically hundreds of m/s above background speeds. The reverse study reveals that flow enhancements associated with streamers (60%) and enhanced larger-scale convection (37%) contribute to SAPS flow enhancements. The strong correlation of auroral streamers with rapid evolution (approximately minutes) of SAPS flows suggests that transient fast earthward plasma sheet flows can often lead to westward SAPS flow enhancements in the subauroral region and that such enhancements are far more common than only during substorms because of the much more frequent occurrences of streamers under various geomagnetic conditions. We also found a strong correlation between flow duration and streamer duration and a weak correlation between SAPS flow velocity and streamer intensity. This result suggests that intense flow bursts in the plasma sheet (which correlate with intense streamers) are associated with intense SAPS ionospheric flows perhaps by enhancing the ring current pressure and localized pressure gradients when they are able to penetrate close enough to Earth.

Experiments of steady state head and torque of centrifugal pumps in two-phase flow

International Nuclear Information System (INIS)

Minato, Akihiko; Tominaga, Kenji.

1988-01-01

Circulation pump behavior has large effect on coolant discharge flow rate in case of reactor pipe break. Experiment of two-phase pump performance was conducted as a joint study of Japanese BWR user utilities and makers. Two-phase head and torque of three centrifugal pumps in high temperature and high pressure (around 6 MPa) steam/water were measured. Head was decreased from single-phase characteristics when gas was mixed in liquid flow in condition with normal flow and normal rotation directions. When flow rate was large enough, two-phase head was about the same as single-phase one in reversal flow conditions. Two-phase head was smoothly increased as flowing steam volumetic concentration increased when flow rate was small and flow direction was reversal. Changes of torque with gas concentration were correspondent to those of head. This suggested that changes of interaction between flow and impellers due to phase slip effected on torque which caused head differences between single- and two-phase flows. Dependence of dimensionless head and torque of three test pumps on steam concentration were almost the same as each other. (author)

Two-phase flow instabilities in a vertical annular channel

Energy Technology Data Exchange (ETDEWEB)

Babelli, I.; Nair, S.; Ishii, M. [Purdue Univ., West Lafayette, IN (United States)

1995-09-01

An experimental test facility was built to study two-phase flow instabilities in vertical annular channel with emphasis on downward flow under low pressure and low flow conditions. The specific geometry of the test section is similar to the fuel-target sub-channel of the Savannah River Site (SRS) Mark 22 fuel assembly. Critical Heat Flux (CHF) was observed following flow excursion and flow reversal in the test section. Density wave instability was not recorded in this series of experimental runs. The results of this experimental study show that flow excursion is the dominant instability mode under low flow, low pressure, and down flow conditions. The onset of instability data are plotted on the subcooling-Zuber (phase change) numbers stability plane.

Prevention of nuclear war

International Nuclear Information System (INIS)

Anon.

1990-01-01

Removing the threat of a nuclear war-as the General Assembly formally stated in the Final Document of its first special session devoted to disarmament, in 1978-is considered to be the task of the present day. In that Document, the General Assembly sought to establish principles, guidelines and procedures for preventing nuclear war. It declared that to that end, it was imperative to remove the threat of nuclear weapons, to halt and reverse the nuclear-arms race until the total elimination of nuclear weapons and their delivery systems had been achieved (see chapter iv), and to prevent the proliferation of nuclear weapons (see chapter VII). At the same time, it called for other measures designed to prevent the outbreak of nuclear war and to lessen the danger of the treat or use of nuclear weapons. The Assembly's clear call for action was dictated by the awareness that there was no insuperable barrier dividing peace from war and that, unless nations brought the spiralling nuclear-arms race to an end, the day might come when nuclear weapons would actually be used, with catastrophic consequences. In adopting the Final Document, the international community achieved, for the first time, a consensus on an international disarmament strategy having as its immediate goal the elimination of the danger of a nuclear war and the implementation of measures to halt and reverse the arms race. The General Assembly, at its second special session on disarmament, in 1982, reaffirmed the validity of the 1978 Final Document. This paper reports that nuclear issues and in particular the prevention of nuclear war remain, however, major concerns of all States. Undoubtedly, all nations have a vital interest in the negotiation of effective measures for her prevention of nuclear war, since nuclear weapons pose a unique threat to human survival. If nuclear war were to occur, its consequences would be global, not simple regional

Flow in data racks

Directory of Open Access Journals (Sweden)

Manoch Lukáš

2014-03-01

Full Text Available This paper deals with the flow in data racks. The aim of this work is to find a new arrangement of elements regulating the flow in the data rack so that the aerodynamic losses and the recirculation zones were minimized. The main reason for solving this problem is to reduce the costs of data racks cooling. Another problem to be solved is a reverse flow in the servers, thus not cooled, occuring due to the underpressure in the recirculation zones. In order to solve the problem, the experimental and numerical model of 27U data rack fitted with 10 pieces of server models with a total input of 10 kW was created. Different configurations of layout of elements affecting the flow in the inlet area of the data rack were compared. Depending on the results achieved, design solutions for the improvement of existing solutions were adopted and verified by numerical simulations.

Study on optimal performance and working temperatures of endoreversible forward and reverse Carnot cycles

Energy Technology Data Exchange (ETDEWEB)

Chen, W.Z.; Sun, F.R.; Cheng, S.M.; Chen, L.G. [Huazhong Univ. of Sceince and Technology, Wuhan (China). Dept. of Power Engineering

1995-12-01

The connection between the expressions of optimization performances of Carnot heat engines, refrigerators and heat pumps, which operate subject to irreversible heat flow, is studied. We consider the endoreversible forward and reverse. Carnot cycles and analyse the expressions which relate efficiency, refrigeration and heating coefficients to power, refrigeration and heating rates, respectively. It is found and proved that when one of the optimal relations is derived the others are also determined, and give the unified formulation of the related optimal working temperatures of the forward and reverse Carnot cycles by isentropic temperature ratio exponent. Finally, several new optimal performance relations are derived for forward and reverse Carnot cycles under nonlinear heat transfer, and some major results in the references are easily deduced and unified in this paper. (author)

Quantum reversibility is relative, or does a quantum measurement reset initial conditions?

Science.gov (United States)

Zurek, Wojciech H

2018-07-13

I compare the role of the information in classical and quantum dynamics by examining the relation between information flows in measurements and the ability of observers to reverse evolutions. I show that in the Newtonian dynamics reversibility is unaffected by the observer's retention of the information about the measurement outcome. By contrast-even though quantum dynamics is unitary, hence, reversible-reversing quantum evolution that led to a measurement becomes, in principle, impossible for an observer who keeps the record of its outcome. Thus, quantum irreversibility can result from the information gain rather than just its loss-rather than just an increase of the (von Neumann) entropy. Recording of the outcome of the measurement resets, in effect, initial conditions within the observer's (branch of) the Universe. Nevertheless, I also show that the observer's friend-an agent who knows what measurement was successfully carried out and can confirm that the observer knows the outcome but resists his curiosity and does not find out the result-can, in principle, undo the measurement. This relativity of quantum reversibility sheds new light on the origin of the arrow of time and elucidates the role of information in classical and quantum physics. Quantum discord appears as a natural measure of the extent to which dissemination of information about the outcome affects the ability to reverse the measurement.This article is part of a discussion meeting issue 'Foundations of quantum mechanics and their impact on contemporary society'. © 2018 The Author(s).

Study of plasma equilibrium during the AC current reversal phase in STOR-M

International Nuclear Information System (INIS)

Xiao, C.

2002-01-01

Alternating current (AC) tokamak operation and equilibrium studies have been performed on the STOR-M tokamak. The recent experiments have achieved consistent smooth current reversal through the implementation of a hybrid digital-analog position controller and by careful density control. In order to study the plasma equilibrium during the current reversal phase with negligible rotational transform, a segmented limiter with four isolated conducting plates has been installed. The plates can be connected outside the vacuum vessel, which allows measurements of currents flowing between limiter plates. When the current reversal is smooth with zero dwell time, the hydrogen line emission level and electron density remain finite, indicating a finite particle confinement. The current from the top to the bottom limiter plate is also finite and its direction is consistent with that of the grad-B drift. The observation suggests that the limiter and other conducting structures surrounding the plasmas plays the role, during the current reversal phase of AC tokamak operation, to short out the charge separation arising from the grad-B drift and to maintain a finite particle confinement. (author)

Reverse Estuarine Circulation Due to Local and Remote Wind Forcing, Enhanced by the Presence of Along-Coast Estuaries

Science.gov (United States)

Giddings, S. N.; MacCready, P.

2017-12-01

Estuarine exchange flow governs the interaction between oceans and estuaries and thus plays a large role in their biogeochemical processes. This study investigates the variability in estuarine exchange flow due to offshore oceanic conditions including upwelling/downwelling, and the presence of a river plume offshore (from a neighboring estuary). We address these processes via numerical simulations at the mouth of the Salish Sea, a large estuarine system in the Northeast Pacific. An analysis of the Total Exchange Flow indicates that during the upwelling season, the exchange flow is fairly consistent in magnitude and oriented in a positive (into the estuary at depth and out at the surface) direction. However, during periods of downwelling favorable winds, the exchange flow shows significantly more variability including multiple reversals, consistent with observations, and surface intrusions of the Columbia River plume which originates 250 km to the south. Numerical along-strait momentum budgets show that the exchange flow is forced dominantly by the pressure gradients, particularly the baroclinic. The pressure gradient is modified by Coriolis and sometimes advection, highlighting the importance of geostrophy and local adjustments. In experiments conducted without the offshore river plume, reversals still occur but are weaker, and the baroclinic pressure gradient plays a reduced role. These results suggest that estuaries along strong upwelling coastlines should experience significant modulation in the exchange flow during upwelling versus downwelling conditions. Additionally, they highlight the importance of nearby estuaries impacting one-another, not only in terms of connectivity, but also altering the exchange flow.Plain Language SummaryEstuarine systems provide extensive biological and ecological functions as well as contribute to human uses and economies. However, estuaries are susceptible to change and most estuaries have been significantly impacted, threatening

Protection system for minimizing the consequences of a flow blockage incident at a pool-type research reactor

International Nuclear Information System (INIS)

de Vries, J.W.; van Dam, H.; Gysler, G.

1990-01-01

Safety analysis activities were performed for the HOR, a pool-type research reactor with plate-type fuel elements and a maximum licensed power of 3 MW. Following internationally accepted guidelines, a wide variety of possible process disturbances has been considered. For the HOR the most aggravating accident conditions could result from a sudden flow blockage of cooling channels. If this event occurs in the high power density region of the core, a decrease of the hot channel flow either causes flow reversal or prompts burnout. Unless the reactor is scrammed in time, the fuel plates will heat up rapidly and local melting will occur with possible propagation of voiding and burnout to adjacent channels. In the analysis, melting of the cladding has been considered by using a simplified model approach. The number of voided coolant channels, as well as the propagation rate of fuel plates reaching locally the melting temperature, were calculated for different conditions of operation. In order to reduce the risk of a fuel melt accident occurring at the HOR, the protection system features a special design option. The system recognizes cooling channel voiding by detection of a sudden decrease of neutron flux. In the present work, it has been shown that a flow blockage incident can be detected in the early stages of development. Also, in accordance with the results of experimental tests, it can be concluded that in many cases melting of fuel plates will be effectively prevented. If such an accident occurs on a very fast time scale, at least the radiological consequences are significantly mitigated by preventing propagation, thus limiting the number of molten fuel plates

Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes

Directory of Open Access Journals (Sweden)

Itoh A

2017-05-01

Full Text Available Arata Itoh, William M Ridgway Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA Abstract: Type 1 diabetes (T1D is characterized by specific destruction of pancreatic insulin-producing beta cells accompanied by evidence of beta-cell-directed autoimmunity such as autoreactive T cells and islet autoantibodies (IAAs. Currently, T1D cannot be prevented or reversed in humans. T1D is easy to prevent in the nonobese diabetic (NOD spontaneous mouse model but reversing new-onset T1D in mice is more difficult. Since the discovery of the T-cell receptor in the 1980s and the subsequent identification of autoreactive T cells directed toward beta-cell antigens (eg, insulin, glutamic acid decarboxylase, the dream of antigen-specific immunotherapy has dominated the field with its promise of specificity and limited side effects. While such approaches have worked in the NOD mouse, however, dozens of human trials have failed. Broader immunosuppressive approaches (originally cyclosporine, subsequently anti-CD3 antibody have shown partial successes (e.g., prolonged C peptide preservation but no major therapeutic efficacy or disease reversal. Human prevention trials have failed, despite the ease of such approaches in the NOD mouse. In the past 50 years, the incidence of T1D has increased dramatically, and one explanation is the “hygiene hypothesis”, which suggests that decreased exposure of the innate immune system to environmental immune stimulants (e.g., bacterial products such as Toll-like receptor (TLR 4-stimulating lipopolysaccharide [LPS] dramatically affects the adaptive immune system and increases subsequent autoimmunity. We have tested the role of innate immunity in autoimmune T1D by treating acute-onset T1D in NOD mice with anti-TLR4/MD-2 agonistic antibodies and have shown a high rate of disease reversal. The TLR4 antibodies do not directly stimulate T cells but induce tolerogenic

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

Directory of Open Access Journals (Sweden)

Sushrusha eNayak

2011-12-01

Full Text Available Intramuscular (IM administration of an adeno-associated viral (AAV vector represents a simple and safe method of gene transfer for treatment of the X-linked bleeding disorder hemophilia B (factor IX, F.IX, deficiency. However, the approach is hampered by an increased risk of immune responses against F.IX. Previously, we demonstrated that the drug cocktail of immune suppressants rapamycin, IL-10, and a specific peptide (encoding a dominant CD4+ T cell epitope caused an induction of regulatory T cells (Treg with a concomitant apoptosis of antigen-specific effector T cells (J. Thromb. Haemost. 7:1523, 2009. This protocol was effective in preventing inhibitory antibody formation against human F.IX (hF.IX in muscle gene transfer to C3H/HeJ hemophilia B mice (with targeted F9 gene deletion. Here, we show that this protocol can also be used to reverse inhibitor formation. IM injection of AAV1-hF.IX vector resulted in inhibitors of on average 8-10 BU within 1 month. Subsequent treatment with the tolerogenic cocktail accomplished a rapid reduction of hF.IX-specific antibodies to <2 BU, which lasted for >4.5 months. Systemic hF.IX expression increased from undetectable to >200 ng/ml, and coagulation times improved. In addition, we developed an alternative prophylactic protocol against inhibitor formation that did not require knowledge of T cell epitopes, consisting of daily oral administration of rapamycin for 1-month combined with frequent, low-dose intravenous injection of hF.IX protein. Experiments in T cell receptor transgenic mice showed that the route and dosing schedule of drug administration substantially affected Treg induction. When combined with intravenous antigen administration, oral delivery of rapamycin had to be performed daily in order to induce Treg, which were suppressive and phenotypically comparable to natural Treg.

Evidence for a new geomagnetic reversal from lava flows in Idaho: discussion of short polarity reversals in the Brunhes and late Matuyama Polarity Chrons

Science.gov (United States)

Champion, D.E.; Lanphere, M.A.; Kuntz, M.A.

1988-01-01

K-Ar ages and paleomagnetic data for basalt samples from a new core hole (site E) at the Idaho National Engineering Laboratory (INEL) indicate that the age of the reversed polarity event recorded in Snake River Plain lavas is older than 465 ?? 50 ka (1000 years before present) reported previously by Champion et al. (1981). A review of data documenting short reversal records from volcanic and sedimentary rocks shows that there is evidence for eight polarity subchrons in the Brunhes and two besides the Jaramillo in the late Matuyama. These 10 short subchrons begin to indicate the many short events that Cox (1968) hypothesized must exist if polarity interval lengths have a Poisson distribution. The mean sustained polarity interval length since late Matuyama Chron time is 90 000 years. The similarity of this number with the 105-year period of the Earth's orbital eccentricity suggests anew that linkage between geomagnetic, paleoclimatic, and possible underlying Earth orbital parameters should be evaluated. -from Authors

Reverse Genetics Approaches for the Development of Influenza Vaccines

Science.gov (United States)

Nogales, Aitor; Martínez-Sobrido, Luis

2016-01-01

Influenza viruses cause annual seasonal epidemics and occasional pandemics of human respiratory disease. Influenza virus infections represent a serious public health and economic problem, which are most effectively prevented through vaccination. However, influenza viruses undergo continual antigenic variation, which requires either the annual reformulation of seasonal influenza vaccines or the rapid generation of vaccines against potential pandemic virus strains. The segmented nature of influenza virus allows for the reassortment between two or more viruses within a co-infected cell, and this characteristic has also been harnessed in the laboratory to generate reassortant viruses for their use as either inactivated or live-attenuated influenza vaccines. With the implementation of plasmid-based reverse genetics techniques, it is now possible to engineer recombinant influenza viruses entirely from full-length complementary DNA copies of the viral genome by transfection of susceptible cells. These reverse genetics systems have provided investigators with novel and powerful approaches to answer important questions about the biology of influenza viruses, including the function of viral proteins, their interaction with cellular host factors and the mechanisms of influenza virus transmission and pathogenesis. In addition, reverse genetics techniques have allowed the generation of recombinant influenza viruses, providing a powerful technology to develop both inactivated and live-attenuated influenza vaccines. In this review, we will summarize the current knowledge of state-of-the-art, plasmid-based, influenza reverse genetics approaches and their implementation to provide rapid, convenient, safe and more effective influenza inactivated or live-attenuated vaccines. PMID:28025504

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission.

Science.gov (United States)

Ariën, Kevin K; Venkatraj, Muthusamy; Michiels, Johan; Joossens, Jurgen; Vereecken, Katleen; Van der Veken, Pieter; Abdellati, Saïd; Cuylaerts, Vicky; Crucitti, Tania; Heyndrickx, Leo; Heeres, Jan; Augustyns, Koen; Lewi, Paul J; Vanham, Guido

2013-09-01

Pre-exposure prophylaxis and topical microbicides are important strategies in the prevention of sexual HIV transmission, especially since partial protection has been shown in proof-of-concept studies. In search of new candidate drugs with an improved toxicity profile and with activity against common non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV, we have synthesized and investigated a library of 60 new diaryltriazine analogues. From this library, 15 compounds were evaluated in depth using a broad armamentarium of in vitro assays that are part of a preclinical testing algorithm for microbicide development. Antiviral activity was assessed in a cell line, and in primary human cells, against both subtype B and subtype C HIV-1 and against viruses resistant to therapeutic NNRTIs and the candidate NNRTI microbicide dapivirine. Toxicity towards primary blood-derived cells, cell lines originating from the female reproductive tract and female genital microflora was also studied. We identified several compounds with highly potent antiviral activity and toxicity profiles that are superior to that of dapivirine. In particular, compound UAMC01398 is an interesting new candidate that warrants further investigation because of its superior toxicity profile and potent activity against dapivirine-resistant viruses.

Eye wash water flow direction study: an evaluation of the effectiveness of eye wash devices with opposite directional water flow.

Science.gov (United States)

Fogt, Jennifer S; Jones-Jordan, Lisa A; Barr, Joseph T

2018-01-01

New designs of eye wash stations have been developed in which the direction of water flow from the fountain has been reversed, with two water streams originating nasally in both eyes and flowing toward the temporal side of each eye. No study has been done to determine the ideal direction of water flow coming from the eye wash in relation to the eye. Ophthalmic eye examinations were conducted before and after the use of two eye wash stations with opposite water flow directionality. Fluorescein was instilled in both eyes before using an eye wash to measure the effectiveness of the water flow. Subjects were surveyed upon their experiences using the eye washes. Ophthalmic examination found no significant difference in the efficacy of the eye washes with nasal-to-temporal water flow when compared to temporal-to-nasal water flow direction.

Posterior Reversible Encephalopathy Syndrome (PRES Associated with Eclampsia: A Case Study

Directory of Open Access Journals (Sweden)

Maasoumeh Mirzamoradi

2017-03-01

Full Text Available The occurrence of posterior reversible encephalopathy syndrome (PRES in patients with eclampsia is a rare condition. PRES is a reversible syndrome characterized by headache, seizure, altered mentation and loss of vision associated with white matter changes on imaging. The lesions in PRES are thought to be due to vasogenic oedema, predominantly in the posterior cerebral hemispheres. This study reports a 16-year-old pregnant woman who presented with blindness and seizure. The MRI of her brain showed abnormal signal intensity in the white matter of the occipital and frontal lobes. She was treated successfully with pregnancy termination, anti-hypertensives, anticonvulsants, and supportive care. It is concluded that early diagnosis is important to prevent permanent neurologic damage and mortality.

Model of reverse steam generator

International Nuclear Information System (INIS)

Malasek, V.; Manek, O.; Masek, V.; Riman, J.

1987-01-01

The claim of Czechoslovak discovery no. 239272 is a model designed for the verification of the properties of a reverse steam generator during the penetration of water, steam-water mixture or steam into liquid metal flowing inside the heat exchange tubes. The design may primarily be used for steam generators with a built-in inter-tube structure. The model is provided with several injection devices configured in different heat exchange tubes, spaced at different distances along the model axis. The design consists in that between the pressure and the circumferential casings there are transverse partitions and that in one chamber consisting of the circumferential casings, pressure casing and two adjoining partitions there is only one passage of the injection device through the inter-tube space. (Z.M.). 1 fig

Reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male Wistar rats in response to hypothermia.

Science.gov (United States)

Malakouti, Seyed Mansour; Kourosh Arami, Masoomeh; Sarihi, Abdorahman; Hajizadeh, Sohrab; Behzadi, Gila; Shahidi, Siamak; Komaki, Alireza; Heshmatian, Behnam; Vahabian, Mehrangiz

2008-10-01

The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. Hypothermia was induced in Male Wistar rats and cannula was implanted above the NRM. To evaluate the effect of nucleus inactivation on TBF, the amount of TBF was measured by Laser Doppler in hypothermic rats, before and after lidocaine microinjection into NRM. TBF was also measured after glutamate microinjection to assess the effect of nucleus excitation in hypothermic rats. Results indicated that after dropping TBF by hypothermia, microinjection of lidocaine into NRM significantly decreased TBF from 54.43 +- 5.7 to 46.81 +- 3.4, whereas glutamate microinjection caused a significant increase from 44.194 +- 0.6 to 98 +- 10.0 CONCLUSION: These data suggest that NRM have thermoregulatory effect in response to hypothermia.

Spatial heterogeneity of biofouling under different cross-flow velocities in reverse osmosis membrane systems

KAUST Repository

Farhat, Nadia; Staal, M.; Bucs, Szilard; Van Loosdrecht, M.C.M.; Vrouwenvelder, Johannes S.

2016-01-01

the spatial heterogeneity of biofilm development over the membrane fouling simulator (MFS) length (inlet and outlet part) at three different cross-flow velocities (0.08, 0.12 and 0.16 m/s). The MFS contained sheets of membrane and feed spacer and simulatedComparison of the inlet and outlet position of the MFS showed a more (i) heterogeneous biofilm distribution and a (ii) higher biological activity at the inlet side (first 2.5 cm) for all cross-flow velocities. The lowest cross-flow velocity had

Application of NEA/CSNI standard problem 3 (blowdown and flow reversal in the IETA-1 rig) to the validation of the RELAP-UK Mk IV code

International Nuclear Information System (INIS)

Bryce, W.M.

1977-10-01

NEA/CSNI Standard Problem 3 consists of the modelling of an experiment on the IETI-1 rig, in which there is initially flow upwards through a feeder, heated section and riser. The inlet and outlet are then closed and a breach opened at the bottom so that the flow reverses and the rig depressurises. Calculations of this problem by many countries using several computer codes have been reported and show a wide spread of results. The purpose of the study reported here was the following. First, to show the sensitivity of the calculation of Standard Problem 3. Second, to perform an ab initio best estimate calculation using the RELAP-UK Mark IV code with the standard recommended options, and third, to use the results of the sensitivity study to show where tuning of the RELAP-UK Mark IV recommended model options was required. This study has shown that the calculation of Standard Problem 3 is sensitive to model assumptions and that the use of the loss-of-coolant accident code RELAP-UK Mk IV with the standard recommended model options predicts the experimental results very well over most of the transient. (U.K.)

Separator-Integrated, Reversely Connectable Symmetric Lithium-Ion Battery.

Science.gov (United States)

Wang, Yuhang; Zeng, Jiren; Cui, Xiaoqi; Zhang, Lijuan; Zheng, Gengfeng

2016-02-24

A separator-integrated, reversely connectable, symmetric lithium-ion battery is developed based on carbon-coated Li3V2(PO4)3 nanoparticles and polyvinylidene fluoride-treated separators. The Li3V2(PO4)3 nanoparticles are synthesized via a facile solution route followed by calcination in Ar/H2 atmosphere. Sucrose solution is used as the carbon source for uniform carbon coating on the Li3V2(PO4)3 nanoparticles. Both the carbon and the polyvinylidene fluoride treatments substantially improve the cycling life of the symmetric battery by preventing the dissolution and shuttle of the electroactive Li3V2(PO4)3. The obtained symmetric full cell exhibits a reversible capacity of ≈ 87 mA h g(-1), good cycling stability, and capacity retention of ≈ 70% after 70 cycles. In addition, this type of symmetric full cell can be operated in both forward and reverse connection modes, without any influence on the cycling of the battery. Furthermore, a new separator integration approach is demonstrated, which enables the direct deposition of electroactive materials for the battery assembly and does not affect the electrochemical performance. A 10-tandem-cell battery assembled without differentiating the electrode polarity exhibits a low thickness of ≈ 4.8 mm and a high output voltage of 20.8 V. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Transient molecular orientation and rheology in flow aligning thermotropic liquid crystalline polymers

International Nuclear Information System (INIS)

Ugaz, Victor M.; Burghardt, Wesley R.; Zhou, Weijun; Kornfield, Julia A.

2001-01-01

Quantitative measurements of molecular orientation and rheology are reported for various transient shear flows of a nematic semiflexible copolyether. Unlike the case of lyotropic liquid crystalline polymers (LCPs), whose structure and rheology in shear are dominated by director tumbling, this material exhibits flow aligning behavior. The observed behavior is quite similar to that seen in a copolyester that we have recently studied [Ugaz and Burghardt (1998)], suggesting that flow aligning dynamics may predominate in main-chain thermotropes that incorporate significant chain flexibility. Since the flow aligning regime has received little attention in previous attempts to model the rheology of textured, polydomain LCPs, we attempt to determine whether available models are capable of predicting the orientation and stress response of this class of LCP. We first examine the predictions of the polydomain Ericksen model, an adaptation of Ericksen's transversely isotropic fluid model which accounts for the polydomain distribution of director orientation while neglecting distortional elasticity. This simple model captures a number of qualitative and quantitative features associated with the evolution of orientation and stress during shear flow inception, but cannot cope with reversing flows. To consider the possible role of distortional elasticity in the re-orientation dynamics upon reversal, we evaluate the mesoscopically averaged domain theory of Larson and Doi [Larson and Doi (1991)], which incorporates a phenomenological description of distortional elastic effects. To date, their approach to account for polydomain structure has only been applied to describe tumbling LCPs. We find that it captures the qualitative transient orientation response to flow reversals, but is less successful in describing the evolution of stresses. This is linked to the decoupling approximation adopted during the model's development. Finally, a modified polydomain Ericksen model is introduced

Visual detection of West Nile virus using reverse transcription loop-mediated isothermal amplification combined with a vertical flow visualization strip

Directory of Open Access Journals (Sweden)

Zengguo eCao

2016-04-01

Full Text Available West Nile virus (WNV causes a severe zoonosis, which can lead to a large number of casualties and considerable economic losses. A rapid and accurate identification methodfor WNV for use in field laboratories is urgently needed. Here, a method utilizing reverse transcription loop-mediated isothermal amplification combined with a vertical flow visualization strip (RT-LAMP-VF was developed to detect the envelope (E gene of WNV. The RT-LAMP-VF assay could detect 102 copies/μl ofan WNV RNA standard using a 40 min amplification reaction followed by a 2 min incubationof the amplification product on the visualization strip, and no cross-reaction with other closely related members of theFlavivirus genus was observed. The assay was further evaluated using cells and mouse brain tissues infected with a recombinant rabies virus expressing the E protein of WNV.The assay produced sensitivities of 101.5TCID50/ml and 101.33 TCID50/ml for detection of the recombinant virus in the cells and brain tissues, respectively. Overall, the RT-LAMP-VF assay developed in this study is rapid, simple and effective, and it is therefore suitable for clinical application in the field.

An algebra of reversible computation.

Science.gov (United States)

Wang, Yong

2016-01-01

We design an axiomatization for reversible computation called reversible ACP (RACP). It has four extendible modules: basic reversible processes algebra, algebra of reversible communicating processes, recursion and abstraction. Just like process algebra ACP in classical computing, RACP can be treated as an axiomatization foundation for reversible computation.

On thermodynamic and microscopic reversibility

International Nuclear Information System (INIS)

Crooks, Gavin E

2011-01-01

The word 'reversible' has two (apparently) distinct applications in statistical thermodynamics. A thermodynamically reversible process indicates an experimental protocol for which the entropy change is zero, whereas the principle of microscopic reversibility asserts that the probability of any trajectory of a system through phase space equals that of the time reversed trajectory. However, these two terms are actually synonymous: a thermodynamically reversible process is microscopically reversible, and vice versa

Numerical Prediction of the Influence of Thrust Reverser on Aeroengine's Aerodynamic Stability

Science.gov (United States)

Zhiqiang, Wang; Xigang, Shen; Jun, Hu; Xiang, Gao; Liping, Liu

2017-11-01

A numerical method was developed to predict the aerodynamic stability of a high bypass ratio turbofan engine, at the landing stage of a large transport aircraft, when the thrust reverser was deployed. 3D CFD simulation and 2D aeroengine aerodynamic stability analysis code were performed in this work, the former is to achieve distortion coefficient for the analysis of engine stability. The 3D CFD simulation was divided into two steps, the single engine calculation and the integrated aircraft and engine calculation. Results of the CFD simulation show that with the decreasing of relative wind Mach number, the engine inlet will suffer more severe flow distortion. The total pressure and total temperature distortion coefficients at the inlet of the engines were obtained from the results of the numerical simulation. Then an aeroengine aerodynamic stability analysis program was used to quantitatively analyze the aerodynamic stability of the high bypass ratio turbofan engine. The results of the stability analysis show that the engine can work stably, when the reverser flow is re-ingested. But the anti-distortion ability of the booster is weaker than that of the fan and high pressure compressor. It is a weak link of engine stability.

Reversible obstructive sleep apnea caused by occupational exposure to guar gum dust.

Science.gov (United States)

Leznoff, A; Haight, J S; Hoffstein, V

1986-05-01

This report describes a case of reversible obstructive sleep apnea caused by occupational exposure to an inhaled allergen, guar gum powder. The patient, a pet food plant employee, also experienced severe cough, rhinitis, and conjunctivitis. Skin tests confirmed the specific guar allergy. Pharyngeal cross-sectional area was smaller than normal. Pulmonary function studies, histamine challenge tests, nasal air-flow resistance measurements, and nocturnal polysomnography were performed on 3 separate occasions: while the patient was working at his usual occupation, at the end of a 3-wk holiday, and after a guar dust challenge in an inhalation chamber. Pulmonary function and histamine challenge tests were consistently normal. At the time of the initial tests, nasal resistance was elevated, and nocturnal polysomnography revealed obstructive sleep apnea. After absence from work, obstructive sleep apnea resolved, and the nasal resistance returned to normal. After challenge with guar gum dust, the patient developed increased resistance to nasal air flow, and obstructive sleep apnea reappeared. This case demonstrates that allergy can cause reversible obstructive sleep apnea and that occupational exposure should be considered in the assessment of patients with this disease.

Manual and Flow-Injection Detection/Quantification of Polyquaterniums via Fully Reversible Polyion-Sensitive Polymeric Membrane-Based Ion-Selective Electrodes.

Science.gov (United States)

Ferguson, Stephen A; Meyerhoff, Mark E

2017-10-27

The detection of four different polyquaterniums (PQs) using a fully reversible potentiometric polyion sensor in three different detection modes is described. The polyion sensing "pulstrodes" serve as the detector for direct dose-response experiments, beaker titrations, and in a flow-injection analysis (FIA) system. Direct polycation response toward PQ-2, PQ-6, PQ-10, and poly(2-methacryloxyethyltrimethylammonium) chloride (PMETAC) yields characteristic information about each PQ species (e.g., relative charge densities, etc.) via syringe pump addition of each PQ species to a background electrolyte solution. Quantitative titrations are performed using a syringe pump to deliver heparin as the polyanion titrant to quantify all four PQs at μg/mL levels. Both the direct and indirect methods incorporate the use of a three-electrode system including counter, double junction reference, and working electrodes. The working electrode possesses a plasticized poly(vinyl chloride) (PVC) membrane containing the neutral lipophilic salt of dinonylnaphthalenesulfonate (DNNS - ) tridodecylmethylammonium (TDMA + ). Further, the titration method is shown to be useful to quantify PQ-6 levels in recreational swimming pool water collected in Ann Arbor, MI. Finally, a FIA system equipped with a pulstrode detector is used to demonstrate the ability to potentially quantify PQ levels via a more streamlined and semiautomated testing platform.

CO2 saturated water as two-phase flow for fouling control in reverse electrodialysis.

Science.gov (United States)

Moreno, J; de Hart, N; Saakes, M; Nijmeijer, K

2017-11-15

When natural feed waters are used in the operation of a reverse electrodialysis (RED) stack, severe fouling on the ion exchange membranes and spacers occurs. Fouling of the RED stack has a strong influence on the gross power density output; which can decrease up to 50%. Moreover, an increase in the pressure loss occurs between the feed water inlet and outlet, increasing the pumping energy and thus decreasing the net power density that can be obtained. In this work, we extensively investigated the use of CO 2 saturated water as two-phase flow cleaning for fouling mitigation in RED using natural feed waters. Experiments were performed in the REDstack research facility located at the Afsluitdijk (the Netherlands) using natural feed waters for a period of 60 days. Two different gas combinations were experimentally investigated, water/air sparging and water/CO 2 (saturated) injection. Air is an inert gas mixture and induces air sparging in the stack. In the case of CO 2 , nucleation, i.e. the spontaneous formation of bubbles, occurs at the spacer filaments due to depressurization of CO 2 saturated water, inducing cleaning. Results showed that stacks equipped with CO 2 saturated water can produce an average net power density of 0.18 W/m 2 under real fouling conditions with minimal pre-treatment and at a low outside temperature of only 8 °C, whereas the stacks equipped with air sparging could only produce an average net power density of 0.04 W/m 2 . Electrochemical impedance spectroscopy measurements showed that the stacks equipped with air sparging increased in stack resistance due to the presence of stagnant bubbles remaining in the stack after every air injection. Furthermore, the introduction of CO 2 gas in the feed water introduces a pH decrease in the system (carbonated solution) adding an additional cleaning effect in the system, thus avoiding the use of environmentally unwanted cleaning chemicals. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All

Research on the application of the internet of things in reverse logistics information management

Directory of Open Access Journals (Sweden)

Yuexia Gu

2013-09-01

Full Text Available Objective: Combined the current situation with the development trend of reverse logistics, the article focus on the research of Internet of Things application in the reverse logistics information management, starts with the study of reverse logistics information system, and describes the system structure and system process in applying Internet of Things in reverse logistics information management, finally brings forward the constraints like management and economic ones in applying the technology to the system. Research methods: By analyzing the current situation of reverse logistics information system, utilizing literature research methods to put forward characters of reverse logistics information system, and expanding the previous studies on Internet information transmission, we gradually establish the reverse logistics management information system on the basis of the application of Internet of Things. Research Results: Through applying the Internet of Things in the reverse logistics system, we can build a complete close-loop logistics system by linking both extreme ends of positive and negative logistics. Besides, the system will be engaged in data mining in backflow prediction data and re-processing data at regular and irregular intervals. Moreover, advice will be provided to design, purchase, manufacturing and customer service departments for their reference so as to promote respective business. Research Application and Limits: This paper focuses on how the enterprise should apply the Internet of Things technology in reverse logistics, and how to build this system in detail and what the flow planning is made. This thesis is only limited to the analysis of constraints impeding the development of the reverse logistics MIS, including management constraints, economic constraints, hardware technology, data security and rights management constraints. Detailed solutions to address these problems will be put forward in the further research.

Dexamethasone Does Not Inhibit Sugammadex Reversal After Rocuronium-Induced Neuromuscular Block.

Science.gov (United States)

Buonanno, Pasquale; Laiola, Anna; Palumbo, Chiara; Spinelli, Gianmario; Servillo, Giuseppe; Di Minno, Raffaele Maria; Cafiero, Tullio; Di Iorio, Carlo

2016-06-01

Sugammadex is a relatively new molecule that reverses neuromuscular block induced by rocuronium. The particular structure of sugammadex traps the cyclopentanoperhydrophenanthrene ring of rocuronium in its hydrophobic cavity. Dexamethasone shares the same steroidal structure with rocuronium. Studies in vitro have demonstrated that dexamethasone interacts with sugammadex, reducing its efficacy. In this study, we investigated the clinical relevance of this interaction and its influence on neuromuscular reversal. In this retrospective case-control study, we analyzed data from 45 patients divided into 3 groups: dexamethasone after induction group (15 patients) treated with 8 mg dexamethasone as an antiemetic drug shortly after induction of anesthesia; dexamethasone before reversal group (15 patients) treated with dexamethasone just before sugammadex injection; and control group (15 patients) treated with 8 mg ondansetron. All groups received 0.6 mg/kg rocuronium at induction, 0.15 mg/kg rocuronium at train-of-four ratio (TOF) 2 for neuromuscular relaxation, and 2 mg/kg sugammadex for reversal at the end of the procedure at TOF2. Neuromuscular relaxation was monitored with a TOF-Watch® system. The control group had a recovery time of 154 ± 54 seconds (mean ± SD), the dexamethasone after induction group 134 ± 55 seconds, and the dexamethasone before reversal group 131 ± 68 seconds. The differences among groups were not statistically significant (P = 0.5141). Our results show that the use of dexamethasone as an antiemetic drug for the prevention of postoperative nausea and vomiting does not interfere with reversal of neuromuscular blockade with sugammadex in patients undergoing elective surgery with general anesthesia in contrast to in vitro studies that support this hypothesis.

Reversibility of female sterilization.

Science.gov (United States)

Siegler, A M; Hulka, J; Peretz, A

1985-04-01

The discussion considers the current status of reversibility of sterilization in the US and describes clinical and experimental efforts for developing techniques designed for reversibility. It focuses on regret following sterilization, reversal potential of current sterilization techniques, patient selection, current reversal techniques, results of sterilization procedures, experimental approaches to reversal of current techniques of sterilization, and sterilization procedures devised for reversibility, in humans and in animals. Request is the 1st stage of reversal, but a request for sterilization reversal (SR) does not always mean regret for a decision made at the time. Frequently it is a wish to restore fertility because life circumstances have changed after a sterilization that was ppropriate at the time it was performed. Schwyhart and Kutner reviewed 22 studies published between 1949-69 in which they found that the percentage of patients regretting the procedure ranged from 1.3-15%. Requests for reversal remain low in most countries, but if sterilization becomes a more popular method of contraception, requests will also increase. The ideal operation considered as a reversaible method of sterilization should include an easy, reliable outpatient method of tubal occlusion with miniml risk or patient discomfort that subsequently could be reversed without the need for a major surgical intervention. Endoscopic methods have progressed toward the 1st objective. A recent search of the literature uncovered few series of SR of more than 50 cases. The 767 operations found were analyzed with regard to pregnancy outcome. The precent of live births varied from 74-78.8%, and the occurance of tubal pregnancies ranged from 1.7-6.5%. All of the confounding variables in patient selection and small numbers of reported procedures preclude any conclusion about the different techniques or the number of operations that give a surgeon a level of expertise. Few authors classify their

Absolute paleointensities during a mid Miocene reversal of the Earth's magnetic field recorded on Gran Canaria (Canary Islands)

Science.gov (United States)

Leonhardt, R.; Soffel, H. C.

2001-12-01

An extensive paleointensity study was carried out on an approximately 14.1 Myr old reverse to normal transition of the geomagnetic field. One hundred eighty-eight samples from a mid Miocene volcanic sequence on Gran Canaria (Canary Islands) were subjected to Thellier-type paleointensity determinations. Samples for paleointensity experiments were selected on the basis of high Curie temperatures, low viscosity indexes, and limited variations of the remanence-carrying magnetic content during thermal treatment. A modified Thellier technique, which facilitates the recognition of MD tails and the formation of new magnetic remanences with higher blocking temperatures than the actual heating step, was used on the majority of the samples. The application of this technique proved to be very successful and we obtained reliable paleointensity results for 35% of the 87 sampled lava flows. In general, the intensity of the reversed and normal magnetized parts of the sequence, before and after the transition, is lower than the field intensity expected for the mid Miocene. This observation is very likely related to a long term reduction of the field close to transitions. The mean field intensity after the reversal ( ~ 17 μ T) is about twice the value of that recorded in the rocks prior to the reversal. This observation points at a fast recovery of the dipolar structure of the field after this reversal. Very low paleointensities with values < 5 μ T were obtained during an excursion, preceding the actual transition, and also close to significant changes of the local field directions during the reversal. This is interpreted as non-dipolar components becoming dominant for short periods and provoking a rapid change of local field directions. During the transition 15 successive lava flows recorded similar local field directions corresponding to a cluster of virtual geomagnetic poles close to South America. Chronologically, within this cluster the paleointensity increases from about 9 �

Mutual learning and reverse innovation--where next?

Science.gov (United States)

Crisp, Nigel

2014-03-28

There is a clear and evident need for mutual learning in global health systems. It is increasingly recognized that innovation needs to be sourced globally and that we need to think in terms of co-development as ideas are developed and spread from richer to poorer countries and vice versa. The Globalization and Health journal's ongoing thematic series, "Reverse innovation in global health systems: learning from low-income countries" illustrates how mutual learning and ideas about so-called "reverse innovation" or "frugal innovation" are being developed and utilized by researchers and practitioners around the world. The knowledge emerging from the series is already catalyzing change and challenging the status quo in global health. The path to truly "global innovation flow", although not fully established, is now well under way. Mobilization of knowledge and resources through continuous communication and awareness raising can help sustain this movement. Global health learning laboratories, where partners can support each other in generating and sharing lessons, have the potential to construct solutions for the world. At the heart of this dialogue is a focus on creating practical local solutions and, simultaneously, drawing out the lessons for the whole world.

Targeted Endovascular Temporary Vessel Occlusion with a Reverse Thermosensitive Polymer for Near-Bloodless Partial Nephrectomy: Comparison to Standard Surgical Clamping Techniques

Energy Technology Data Exchange (ETDEWEB)

Flacke, Sebastian, E-mail: Sebastian.Flacke@lahey.org [Lahey Clinic, Tuft University Medical School, Department of Radiology (United States); Harty, Niall J.; Laskey, Daniel H.; Moinzadeh, Alireza [Lahey Clinic, Tuft University Medical School, Department of Urology (United States); Benn, James A. [Pluromed Inc (United States); Villani, Rosanna [DaVinci Biomedical Research Products (United States); Kalra, Aarti [Lahey Clinic, Tuft University Medical School, Department of Pathology (United States); Libertino, John A.; Madras, Peter N. [Lahey Clinic, Tuft University Medical School, Department of Urology (United States)

2012-10-15

Purpose: To determine whether reversible blood flow interruption to a randomly chosen target region of the kidney may be achieved with the injection of a reverse thermoplastic polymer through an angiographic catheter, thereby facilitating partial nephrectomy without compromising blood flow to the remaining kidney or adding risks beyond those encountered by the use of hilar clamping. Methods: Fifteen pigs underwent partial nephrectomy after blood flow interruption by vascular cross-clamping or injection of polymer (Lumagel Trade-Mark-Sign ) into a segmental artery. Five animals were euthanized after surgery (three open and two laparoscopic resection, cross-clamping n = 2), and 10 (open resection, cross-clamping n = 4) were euthanized after 6 weeks' survival. Blood specimens were obtained periodically, and angiogram and necropsy were performed at 6 weeks. Results: Selective renal ischemia was achieved in all cases. Surgical resection time averaged 9 and 24.5 min in the open and laparoscopic groups, respectively. Estimated blood loss was negligible with the exception of one case where an accessory renal artery was originally overlooked. Reversal of the polymer to a liquid state was consistent angiographically and visually in all cases. Time to complete flow return averaged 7.4 and 2 min for polymer and clamping, respectively. Angiography at 6 weeks revealed no evidence of vascular injury. Laboratory data and necropsies revealed no differences between animals undergoing vascular clamping or polymer injection. Conclusion: Lumagel was as effective as vascular clamping in producing a near bloodless operative field for partial nephrectomy while maintaining flow to the uninvolved portion of the affected kidney.

Implications of Reverse Innovation for Socio-Economic Sustainability: A Case Study of Philips China

Directory of Open Access Journals (Sweden)

Juan Shan

2016-06-01

Full Text Available The idea of reverse innovation, local innovation happening in emerging markets for the global market, has gained much academic and managerial attention in recent years. The purpose of this study is to understand how reverse innovation has successfully diffused into the product and market development strategies at Philips Inc., a prominent multinational company (MNC of the modern era. Furthermore, the study presents the success achieved by these innovations at both the domestic and global levels, along with their implications regarding socio-economic sustainability in emerging markets. In order to investigate the research questions, a case study of Philips China was conducted involving three product innovations that were found to be suitable examples of reverse innovation. After the study of extant literature on the topic, drawing from research databases, newspaper articles, and company press releases, five semi-structuredinterviews were conducted with key managers and a market practitioner to gain sufficient understanding for this exploratory study. Subsequent case analysis concludes that these innovations are examples of reverse innovation representing a new paradigm change in innovation flow. This flow of innovation from emerging markets to developed markets as confirmed by Corsi’s framework could potentially disrupt developed markets as well as contribute to ensure healthy living conditions for the population living in developing countries. If so, this represents a sustainable socio-economic change in-line with the United Nations' Sustainable Development Goal (SDG of “ensuring healthy lives and promoting well-being for all at all ages.” This is relevant as Philips aspires to be a prominent private sector player in achieving the above-stated goal by defeating non-communicable disease and strengthening local healthcare systems.

How the reverse supply chain contributes to a firm’s competitive strategy: a strategic alignment perspective

DEFF Research Database (Denmark)

Larsen, Samuel Brüning; Masi, Donato; Jacobsen, Peter

2017-01-01

The ongoing transition to a Circular Economy is changing the shape of Supply Chains. They are becoming more ‘Closed-Loop’, combining forward and reverse flows of products and materials. Reverse Supply Chains (RSCs), originally considered as a solution for handling waste or recovering residual value...... seven case studies, focusing on original equipment manufacturers (OEMs), show how the RSC can play a strategic, tactical, or operational role for the firm. The paper applies for the first time the concept of strategic alignment to the RSC and practitioners can use the proposed framework to analyse...

Chiral cavity ring down polarimetry: Chirality and magnetometry measurements using signal reversals.

Science.gov (United States)

Bougas, Lykourgos; Sofikitis, Dimitris; Katsoprinakis, Georgios E; Spiliotis, Alexandros K; Tzallas, Paraskevas; Loppinet, Benoit; Rakitzis, T Peter

2015-09-14

We present the theory and experimental details for chiral-cavity-ring-down polarimetry and magnetometry, based on ring cavities supporting counterpropagating laser beams. The optical-rotation symmetry is broken by the presence of both chiral and Faraday birefringence, giving rise to signal reversals which allow rapid background subtractions. We present the measurement of the specific rotation at 800 nm of vapors of α-pinene, 2-butanol, and α-phellandrene, the measurement of optical rotation of sucrose solutions in a flow cell, the measurement of the Verdet constant of fused silica, and measurements and theoretical treatment of evanescent-wave optical rotation at a prism surface. Therefore, these signal-enhancing and signal-reversing methods open the way for ultrasensitive polarimetry measurements in gases, liquids and solids, and at surfaces.

Plasma-gun-assisted field-reversed configuration formation in a conical θ-pinch

Energy Technology Data Exchange (ETDEWEB)

Weber, T. E., E-mail: tweber@lanl.gov; Intrator, T. P. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Smith, R. J. [Department of Aeronautics and Astronautics, University of Washington, Seattle, Washington 98195 (United States)

2015-04-15

Injection of plasma via an annular array of coaxial plasma guns during the pre-ionization phase of field-reversed configuration (FRC) formation is shown to catalyze the bulk ionization of a neutral gas prefill in the presence of a strong axial magnetic field and change the character of outward flux flow during field-reversal from a convective process to a much slower resistive diffusion process. This approach has been found to significantly improve FRC formation in a conical θ-pinch, resulting in a ∼350% increase in trapped flux at typical operating conditions, an expansion of accessible formation parameter space to lower densities and higher temperatures, and a reduction or elimination of several deleterious effects associated with the pre-ionization phase.

Plasma-gun-assisted field-reversed configuration formation in a conical θ-pinch

Science.gov (United States)

Weber, T. E.; Intrator, T. P.; Smith, R. J.

2015-04-01

Injection of plasma via an annular array of coaxial plasma guns during the pre-ionization phase of field-reversed configuration (FRC) formation is shown to catalyze the bulk ionization of a neutral gas prefill in the presence of a strong axial magnetic field and change the character of outward flux flow during field-reversal from a convective process to a much slower resistive diffusion process. This approach has been found to significantly improve FRC formation in a conical θ-pinch, resulting in a ˜350% increase in trapped flux at typical operating conditions, an expansion of accessible formation parameter space to lower densities and higher temperatures, and a reduction or elimination of several deleterious effects associated with the pre-ionization phase.

Chiral cavity ring down polarimetry: Chirality and magnetometry measurements using signal reversals

International Nuclear Information System (INIS)

Bougas, Lykourgos; Sofikitis, Dimitris; Katsoprinakis, Georgios E.; Spiliotis, Alexandros K.; Rakitzis, T. Peter; Tzallas, Paraskevas; Loppinet, Benoit

2015-01-01

We present the theory and experimental details for chiral-cavity-ring-down polarimetry and magnetometry, based on ring cavities supporting counterpropagating laser beams. The optical-rotation symmetry is broken by the presence of both chiral and Faraday birefringence, giving rise to signal reversals which allow rapid background subtractions. We present the measurement of the specific rotation at 800 nm of vapors of α-pinene, 2-butanol, and α-phellandrene, the measurement of optical rotation of sucrose solutions in a flow cell, the measurement of the Verdet constant of fused silica, and measurements and theoretical treatment of evanescent-wave optical rotation at a prism surface. Therefore, these signal-enhancing and signal-reversing methods open the way for ultrasensitive polarimetry measurements in gases, liquids and solids, and at surfaces

The detection and prevention of manipulations in the balance sheet and the cash flow statement

Directory of Open Access Journals (Sweden)

Dragomir Dimitrijevic

2015-08-01

Full Text Available Financial statements which consist of objective, real and reliable information represent the key basis for making many business decisions. If, when writing financial statements, certain manipulation techniques are used for displaying the best possible results of transactions, the quality of financial reports will be endangered. Many financial frauds have led to a great mistrust in the system of financial reporting and the profession of accounting and auditing, which are often accused of the emergence of fraud and losing trust in the reliability of financial information by many users and economic decision makers. These are the reasons why the paper discusses the techniques of manipulation in financial statements, especially in balance sheets and cash flow statements, since these forms of manipulation are harder to detect and prevent when compared to manipulations of revenues and expenses in the income statement.

Constraining the reversing and non-reversing modes of the geodynamo. New insights from magnetostratigraphy.

Science.gov (United States)

Gallet, Y.; Pavlov, V.; Shatsillo, A.; Hulot, G.

2015-12-01

Constraining the evolution in the geomagnetic reversal frequency over hundreds of million years is not a trivial matter. Beyond the fact that there are long periods without reversals, known as superchrons, and periods with many reversals, the way the reversal frequency changes through time during reversing periods is still debated. A smooth evolution or a succession of stationary segments have both been suggested to account for the geomagnetic polarity time scale since the Middle-Late Jurassic. Sudden changes from a reversing mode to a non-reversing mode of the geodynamo may also well have happened, the switch between the two modes having then possibly been controlled by the thermal conditions at the core-mantle boundary. There is, nevertheless, a growing set of magnetostratigraphic data, which could help decipher a proper interpretation of the reversal history, in particular in the early Paleozoic and even during the Precambrian. Although yielding a fragmentary record, these data reveal the occurrence of both additional superchrons and periods characterized by extremely high, not to say extraordinary, magnetic reversal frequencies. In this talk, we will present a synthesis of these data, mainly obtained from Siberia, and discuss their implication for the magnetic reversal behavior over the past billion years.

Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission.

Science.gov (United States)

Akil, Ayman; Parniak, Michael A; Dezzuitti, Charlene S; Moncla, Bernard J; Cost, Marilyn R; Li, Mingguang; Rohan, Lisa Cencia

2011-06-01

Dapivirine, a non-nucleoside reverse transcriptase inhibitor, is a potent and promising anti-HIV molecule. It is currently being investigated for use as a vaginal microbicide in two dosage forms, a semi-solid gel and a silicone elastomer ring. Quick-dissolving films are promising and attractive dosage forms that may provide an alternative platform for the vaginal delivery of microbicide drug candidates. Vaginal films may provide advantages such as discreet use, no product leakage during use, lack of requirement for an applicator for insertion, rapid drug release and minimal packaging and reduced wastage. Within this study the in vitro bioactivity of dapivirine as compared to the NNRTI UC781 was further established and a quick dissolve film was developed for vaginal application of dapivirine for prevention of HIV infection. The developed film was characterized with respect to its physical and chemical attributes including water content, mechanical strength, drug release profile, permeability, compatibility with lactobacilli and bioactivity. The anti-HIV activity of the formulated dapivirine film was confirmed in in vitro and ex vivo models. Importantly the physical and chemical properties of the film as well as its bioactivity were maintained for a period of 18 months. In conclusion, a vaginal film containing dapivirine was developed and characterized. The film was shown to prevent HIV-1 infection in vitro and ex vivo and have acceptable characteristics which make this film a promising candidate for testing as vaginal microbicide.

46,XY female sex reversal syndrome with bilateral gonadoblastoma and dysgerminoma.

Science.gov (United States)

DU, Xue; Zhang, Xuhong; Li, Yongmei; Han, Yukun

2014-10-01

Sex reversal syndrome is a rare congenital condition of complete or disordered gonadal development leading to discordance between the genetic, gonadal and phenotypic sexes, including 46,XX and 46,XY. The gonadoblastoma on the Y-chromosome (GBY) region is associated with an increased risk of developing type II germ cell tumors/cancer. The present study reports a unique case of a phenotypically normal female (age 17 years), presenting with primary amenorrhea and later diagnosed with 46,XY female sex reversal syndrome. Following bilateral gonadectomy, bilateral gonadoblastoma and dysgerminoma were diagnosed. Thus, estrogen replacement therapy was administered periodically to promote the development of secondary sexual characteristics and menstruation, and to prevent osteoporosis. A four year follow-up showed no tumor recurrence and a regular menstrual cycle in this patient.

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Directory of Open Access Journals (Sweden)

Carl J. Mallia

2016-07-01

Full Text Available The flow synthesis of ortho-substituted carboxylic acids, using carbon monoxide gas, has been studied for a number of substrates. The optimised conditions make use of a simple catalyst system compromising of triphenylphosphine as the ligand and palladium acetate as the pre-catalyst. Carbon monoxide was introduced via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions.

Seasonal variation of the flow in the strait of Bah al Mandab

OpenAIRE

Smeed, D