Francisco C Santos
Full Text Available Conventional evolutionary game theory predicts that natural selection favours the selfish and strong even though cooperative interactions thrive at all levels of organization in living systems. Recent investigations demonstrated that a limiting factor for the evolution of cooperative interactions is the way in which they are organized, cooperators becoming evolutionarily competitive whenever individuals are constrained to interact with few others along the edges of networks with low average connectivity. Despite this insight, the conundrum of cooperation remains since recent empirical data shows that real networks exhibit typically high average connectivity and associated single-to-broad-scale heterogeneity. Here, a computational model is constructed in which individuals are able to self-organize both their strategy and their social ties throughout evolution, based exclusively on their self-interest. We show that the entangled evolution of individual strategy and network structure constitutes a key mechanism for the sustainability of cooperation in social networks. For a given average connectivity of the population, there is a critical value for the ratio W between the time scales associated with the evolution of strategy and of structure above which cooperators wipe out defectors. Moreover, the emerging social networks exhibit an overall heterogeneity that accounts very well for the diversity of patterns recently found in acquired data on social networks. Finally, heterogeneity is found to become maximal when W reaches its critical value. These results show that simple topological dynamics reflecting the individual capacity for self-organization of social ties can produce realistic networks of high average connectivity with associated single-to-broad-scale heterogeneity. On the other hand, they show that cooperation cannot evolve as a result of "social viscosity" alone in heterogeneous networks with high average connectivity, requiring the
Usol'tsev, V.I.; Serebryanyj, V.A.
The results of an investigation of 352 x-ray cabinets showed that their personnel is subjected to simultaneous action of a number of factors: discomfortable microclimate, small concentrations of ozone and nitrogen oxides (within 0.1 of the maximum permissible concentration). The hands of the personnel, especially those of the x-ray laboratory assistants are contaminated with lead (2.38mg in the hands washings). Therefore the assessment of labour conditions prevailing in an x-ray cabinet and the accomplishment of measures of their provement should be carried out with due regards to all the complex of the above mentioned factors besides the ionizing radiation
Pytharoulis, Ioannis; Tegoulias, Ioannis; Karacostas, Theodore; Kotsopoulos, Stylianos; Kartsios, Stergios; Bampzelis, Dimitrios
The Thessaly plain, which is located in central Greece, has a vital role in the financial life of the country, because of its significant agricultural production. The aim of DAPHNE project (http://www.daphne-meteo.gr) is to tackle the problem of drought in this area by means of Weather Modification in convective clouds. This problem is reinforced by the increase of population and the water demand for irrigation, especially during the warm period of the year. The nonhydrostatic Weather Research and Forecasting model (WRF), is utilized for research and operational purposes of DAPHNE project. The WRF output fields are employed by the partners in order to provide high-resolution meteorological guidance and plan the project's operations. The model domains cover: i) Europe, the Mediterranean sea and northern Africa, ii) Greece and iii) the wider region of Thessaly (at selected periods), at horizontal grid-spacings of 15km, 5km and 1km, respectively, using 2-way telescoping nesting. The aim of this research work is to investigate the model performance in relation to the prevailing upper-air synoptic circulation. The statistical evaluation of the high-resolution operational forecasts of near-surface and upper air fields is performed at a selected period of the operational phase of the project using surface observations, gridded fields and weather radar data. The verification is based on gridded, point and object oriented techniques. The 10 upper-air circulation types, which describe the prevailing conditions over Greece, are employed in the synoptic classification. This methodology allows the identification of model errors that occur and/or are maximized at specific synoptic conditions and may otherwise be obscured in aggregate statistics. Preliminary analysis indicates that the largest errors are associated with cyclonic conditions. Acknowledgments This research work of Daphne project (11SYN_8_1088) is co-funded by the European Union (European Regional Development Fund
A condition is derived for reciprocal altruism to evolve by kin or group selection. It is assumed that many additively acting genes of small effect and the environment determine the probability that an individual is a reciprocal altruist, as opposed to being unconditionally selfish. The particular form of reciprocal altruism considered is TIT FOR TAT, a strategy that involves being altruistic on the first encounter with another individual and doing whatever the other did on the previous encounter in subsequent encounters with the same individual. Encounters are restricted to individuals of the same generation belonging to the same kin or breeding group, but first encounters occur at random within that group. The number of individuals with which an individual interacts is assumed to be the same within any kin or breeding group. There are 1 + i expected encounters between two interacting individuals. On any encounter, it is assumed that an individual who behaves altruistically suffers a cost in personal fitness proportional to c while improving his partner's fitness by the same proportion of b. Then, the condition for kin or group selection to prevail is [Formula: see text] if group size is sufficiently large and the group mean and the within-group genotypic variance of the trait value (i.e., the probability of being a TIT-FOR-TAT strategist) are uncorrelated. Here, C, Vb, and Tb are the population mean, between-group variance, and between-group third central moment of the trait value and r is the correlation between the additive genotypic values of interacting kin or of individuals within the same breeding group. The right-hand side of the above inequality is monotone decreasing in C if we hold Tb/Vb constant, and kin and group selection become superfluous beyond a certain threshold value of C. The effect of finite group size is also considered in a kin-selection model. PMID:6575395
Sanghi, Achint; Ambrose, R P Kingsly
Grain dust explosions have been occurring in the U.S. for the past twenty years. In the past ten years, there have been an average of ten explosions a year, resulting in nine fatalities and 93 injuries. In more than half of these cases, the ignition source remains unidentified. The effect of ambient humidity on the likelihood of a dust explosion has been discussed for many years. However, no investigation into a possible link between the two has been carried out. In this study, we analyzed local weather data and grain dust explosions during the period 2006 to 2014 to measure potential relationships between the two events. The 84 analyzed explosions do not show any trend with regard to prevailing temperatures, or relative or absolute humidity. In addition, the ignition source could not be identified in 54 of the incidents. The majority of grain dust explosion incidents occurred at grain elevator facilities, where the dust generation potential was high compared with grain processing industries. Copyright© by the American Society of Agricultural Engineers.
Maisonneuve, Emeline; Delvin, Edgard; Edgard, Annie; Morin, Lucie; Dubé, Johanne; Boucoiran, Isabelle; Moutquin, Jean-Marie; Fouron, Jean-Claude; Klam, Stephanie; Levy, Emile; Leduc, Line
Intrauterine growth restriction (IUGR) and prenatal exposure to oxidative stress are thought to lead to increased risks of cardiovascular disease later in life. The objective of the present study was to document whether cord blood oxidative stress biomarkers vary with the severity of IUGR and of vascular disease in the twin pregnancy model in which both fetuses share the same maternal environment. This prospective cohort study involved dichorionic twin pairs, with one co-twin with IUGR. Oxidative stress biomarkers were measured in venous cord blood samples from each neonate of 32 twin pairs, and compared, according to severity of IUGR (IUGR <5th percentile), Doppler anomalies of the umbilical artery and early onset IUGR (in the second trimester) of the growth restricted twin. Oxidized Low-Density Lipoproteins (oxLDL) and Malondialdehyde (MDA) concentrations were increased proportionally in cases of severe IUGR. OxLDL concentrations were also increased in cases of IUGR with Doppler anomaly. Our data indicate that severe IUGR, is related to a derangement in redox balance, illustrated by increased venous cord blood oxidative stress biomarkers concentrations. Severe IUGR and IUGR with abnormal Doppler can be translated into conditions with intense oxidative stress.
Marcella Castells i Sanabra
Full Text Available Appendix III of MARPOL's Annex VI sets out the criteria and procedures for designating an emission control area (ECA.These criteria includes: a clear delineation of the proposed ECA; types of emissions proposed for control, land and sea areas at risk; emission quantification and impact assessment; prevailing weather conditions; data and quality on marine traffic; land based measures concurrent with the ECA adoption and the relative costs of reducing emissions from ships. This paper analyses the climate parameter together with traffic conditions: prevailing weather conditions as a parameter to be kept in mind for the adoption of a future ECA in the Mediterranean Sea. Preliminary results would show how marine emissions coming from existing traffic will impact the sea and land ecology in the Mediterranean area.
Arafat, Hassan A; Al-Khatib, Issam A; Zahra, Abdulsalam Abu
Since the start of the second Palestinian uprising (Al-Aqsa Intifada), and due to the Israeli activities, curfews, closures, and military checkpoints imposed since 2000, the quality of social services rendered by Nablus city has been gradually deteriorating. Solid waste management in Nablus city was badly affected by these conditions, and this situation is negatively affecting health and damaging the environment. Most of these cases were due to reasons beyond the capability of the municipality with its limited resources. This study revealed that some of the important municipal solid waste (MSW) equipment had been damaged during the uprising. The workforce in the MSW system was reduced and certain MSW-related development projects and activities have been frozen due to the current conditions. The city's medical waste incinerator had been phased out and the number of special medical containers had been reduced from 16 to 10. Some MSW compressing trucks had been out of use with no substitute. Another important figure is the number of waste collection workers which decreased from 420 to 301, although the city is growing in premises as well as population. The created unsanitary solid waste transfer station is now a pollution source on its own, causing an ugly scene at the eastern entrance of Nablus city. There should be a comprehensive and urgent solution for this problem and the needed resources should be invested.
Analysis of the prevailing standard and technical documents for their applicability under conditions of the 'Ukrytie' operation and technical proposals relating to the elaboration of new ones concerning fire safety
Nazarenko, B.S.; Emets, V.G.
An analysis of the prevailing laws and standards and technical documents (STD) to ensure safe operation of nuclear power installations, with requirements of nuclear, radiation and fire safety taken into account, has been performed. Proposals on application of some items of prevailing STD under conditions of the 'Ukrytie' operation are presented. Also given are technical proposals on correction of the prevailing operational standard documents and elaboration of special STD
Palacios, Maria G; Cunnick, Joan E; Bronikowski, Anne M
The immunocompetence "pace-of-life" hypothesis proposes that fast-living organisms should invest more in innate immune defenses and less in adaptive defenses compared to slow-living ones. We found some support for this hypothesis in two life-history ecotypes of the snake Thamnophis elegans; fast-living individuals show higher levels of innate immunity compared to slow-living ones. Here, we optimized a lymphocyte proliferation assay to assess the complementary prediction that slow-living snakes should in turn show stronger adaptive defenses. We also assessed the "environmental" hypothesis that predicts that slow-living snakes should show lower levels of immune defenses (both innate and adaptive) given the harsher environment they live in. Proliferation of B- and T-lymphocytes of free-living individuals was on average higher in fast-living than slow-living snakes, opposing the pace-of-life hypothesis and supporting the environmental hypothesis. Bactericidal capacity of plasma, an index of innate immunity, did not differ between fast-living and slow-living snakes in this study, contrasting the previously documented pattern and highlighting the importance of annual environmental conditions as determinants of immune profiles of free-living animals. Our results do not negate a link between life history and immunity, as indicated by ecotype-specific relationships between lymphocyte proliferation and body condition, but suggest more subtle nuances than those currently proposed.
Evans, Christopher P; Higano, Celestia S; Keane, Thomas
BACKGROUND: Enzalutamide, an oral androgen receptor inhibitor, significantly improved overall survival (OS) and radiographic progression-free survival (rPFS) versus placebo in the PREVAIL trial of men with chemotherapy-naïve metastatic castration-resistant prostate cancer. OBJECTIVE: To assess...... in men with chemotherapy-naïve metastatic castration-resistant prostate cancer, with or without visceral disease, low- or high-volume bone disease, or lymph node only disease. PATIENT SUMMARY: Patients with metastatic castration-resistant prostate cancer-including those with or without visceral disease...
A growing amount of (semi) public organizations in the Netherlands write tenders with mandatory social conditions. It is important for SMEs to focus on social procurement in their business strategy. SMEs should be proactive and try to affect the conditions (semi) public organizations write in their
Stirling, Wynn C; Felin, Teppo
Neoclassical noncooperative game theory is based on a simple, yet powerful synthesis of mathematical and logical concepts: unconditional and immutable preference orderings and individual rationality. Although this structure has proven useful for characterizing competitive multi-player behavior, its applicability to scenarios involving complex social relationships is problematic. In this paper we directly address this limitation by the introduction of a conditional preference structure that permits players to modulate their preference orderings as functions of the preferences of other players. Embedding this expanded preference structure in a formal and graphical framework provides a systematic approach for characterizing a complex society. The result is an influence network that allows conditional preferences to propagate through the community, resulting in an emergent social model which characterizes all of the social relationships that exist and which leads to solution concepts that account for both group and individual interests. The Ultimatum game is presented as an example of how social influence can be modeled with conditional preferences.
Behaviour of lactic acid bacteria populations in Pecorino di Carmasciano cheese samples submitted to environmental conditions prevailing in the gastrointestinal tract: evaluation by means of a polyphasic approach.
Ricciardi, Annamaria; Blaiotta, Giuseppe; Di Cerbo, Alessandro; Succi, Mariantonietta; Aponte, Maria
The survival of the autochthonous microflora, of samples collected during Pecorino di Carmasciano cheese manufacturing, was evaluated along the passage through a model mimicking the gastro-intestinal tract. The aim was the selection of lactic acid bacteria potentially able to arrive alive and metabolically active to the colon. The dynamics of lactic microbiota, throughout simulated digestion of cheese samples, were evaluated by means of an approach PCR-DGGE-based. Dominant species after cheese digestion could be related to the Lactobacillus plantarum and Lactobacillus casei groups. Sixty-three strains, which survived to simulated gastro-intestinal transit, were further evaluated for technological features and tolerance to human digestion in several experimental conditions, according to routinely used protocols. Bacterial survival appeared to be, more than strain-specific, strongly affected by experimental conditions, i.e. some strains showed an acceptable survival when resuspended in skim milk but not in ewe milk and vice versa. Nevertheless according to data, one gram of fresh Pecorino di Carmasciano cheese may convey to human colon about the same amount of viable LAB of a probiotic drink. Although it cannot be assumed that lactobacilli introduced with Pecorino have beneficial effects on the host, the healthy impact of autochthonous lactic acid bacteria of naturally fermented food has a broad consensus in the current literature. Copyright © 2014 Elsevier B.V. All rights reserved.
Secchi, Myrian Marajó Dal
Full Text Available Introduction: The epistaxis is one the most frequent otorhinolaryngologic emergencies in the medical practice. It is a benign affection, but the refractory cases require hospital admission. Objective: To evaluate prevailing factors in patients with epistaxis and treatment. Form of study: Retrospective study. Method: 60 patients with diagnosis of epistaxis were evaluated and they needed hospital admission between 2005 and 2006. Results: The main prevailing factors were: Systemic arterial hypertension 36% (n= 22, trauma 16% (n=10 and coagulopathy 5% (n=3. The treatment was the use of nasal splint: anterior 58% (n=35 and antero-posterior 27% (n=16, the electrocauterization of the identified bloody point 7% (n=4, endoscopic arterial bandage 8% (n=5 in severe epistaxis. For the patients with antero-posterior splint with recurrence of bleeding in the first 24 hours (five patients, after clinical stabilization, an arterial bandage was indicated by endoscopic means; four patients had systemic arterial hypertension and in one patient no prevailing factor was identified. Conclusion: The main associated prevailing factors were systemic arterial hypertension, trauma and coagulopathy. The treatment depends on the type, severity and cause of bleeding, initially the anterior and antero-posterior splint for bleeding control. The early endoscopic arterial bandage is indicated in patients with severe epistaxis and prevailing factors, and prolonged admission and morbidities associated with nasal splint should be avoided.
... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Prevailing party. 747.603 Section 747.603 Banks... in NCUA Board Adjudications § 747.603 Prevailing party. An eligible applicant may be a “prevailing... dismissed. In appropriate situations an applicant may also have prevailed if the outcome of the proceeding...
Goldblatt, Steven M.; Wood, R. Craig
This chapter presents an up-to-date analysis of prevailing state wage laws that affect educational facility construction or renovation and highlights relevant prevailing wage litigation in many states. Currently, 13 states have no prevailing wage laws for public works. The other 37 states and the District of Columbia do have prevailing wage laws…
Tinoco-González, Daniella; Fullana, Miquel Angel; Torrents-Rodas, David; Bonillo, Albert; Vervliet, Bram; Pailhez, Guillem; Farré, Magí; Andión, Oscar; Perez, Víctor; Torrubia, Rafael
Although enhanced fear conditioning has been implicated in the origins of social anxiety disorder (SAD), laboratory evidence in support of this association is limited. Using a paradigm employing socially relevant unconditioned stimuli, we conducted two separate studies to asses fear conditioning in individuals with SAD and non-clinical individuals with high social anxiety (subclinical social anxiety [SSA]). They were compared with age-matched and gender-matched individuals with another anxiety disorder (panic disorder with agoraphobia) and healthy controls (Study 1) and with individuals with low social anxiety (Study 2). Contrary to our expectations, in both studies, self-report measures (ratings of anxiety, unpleasantness and arousal to the conditioned stimuli) of fear conditioning failed to discriminate between SAD or SSA and the other participant groups. Our results suggest that enhanced fear conditioning does not play a major role in pathological social anxiety. We used a social conditioning paradigm to study fear conditioning in clinical and subclinical social anxiety. We found no evidence of enhanced fear conditioning in social anxiety individuals. Enhanced fear conditioning may not be a hallmark of pathological social anxiety. Copyright © 2014 John Wiley & Sons, Ltd.
Pfeiffer, Hans C.; Golladay, Steven D.; Gordon, Michael S.; Kendall, Rodney A.; Lieberman, Jon E.; Rockrohr, James D.; Stickel, Werner; Yamaguchi, Takeshi; Okamoto, Kazuya; Umemoto, Takaaki; Shimizu, Hiroyasu; Kojima, Shinichi; Hamashima, Muneki
The PREVAIL electron optics subsystem developed by IBM has been installed at Nikon's facility in Kumagaya, Japan, for integration into the Nikon commercial EPL stepper. The cornerstone of the electron optics design is the Curvilinear Variable Axis Lens (CVAL) technique originally demonstrated with a proof of concept system. This paper presents the latest experimental results obtained with the electron optical subsystem at Nikon's facility. The results include micrographs illustrating proper CVAL operation through the spatial resolution achieved over the entire optical field of view. They also include data on the most critical issue of the EPL exposure approach: subfield stitching. The methodology of distortion correction will be described and both micrographs and metrology data of stitched subfields will be presented. This paper represents a progress report of the IBM/Nikon alliance activity on EPL.
... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Prevailing party. 263.102 Section 263.102 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES... Prevailing party. Only an eligible applicant that prevailed on the merits of an adversary proceeding may...
... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Prevailing party. 308.173 Section 308.173 Banks....173 Prevailing party. (a) General rule. An eligible applicant who, following an adversary adjudication has gained victory on the merits in the proceeding is a “prevailing party”. An eligible applicant may...
Cho, Hyun Jung
Estuarine waters are generally more turbid than lakes or marine waters due to greater algal mass and continual re-suspension of sediments. The varying effects of diurnal and seasonal prevailing winds on the turbidity condition of a wind-dominated estuary were investigated by spatial and statistical analyses of wind direction, water level, turbidity, chlorophyll a, and PAR (Photosynthetically Active Radiation) collected in Lake Pontchartrain, Louisiana, USA. The prolonged prevailing winds were...
Markova, N. E.
Currently, four out of five children in Russia's social rehabilitation institutions are "social" orphans, whose parents are still alive. Many of these children are losing their ability to learn in school, and the use of alcohol and narcotics, and early onset of sexual activity, are damaging their future life. These children are involved…
Hernandez, Alan; Hess, Daniel P.
This paper presents results from tests to assess the use of anaerobic adhesive for providing a prevailing torque locking feature in threaded fasteners. Test procedures are developed and tests are performed on three fastener materials, four anaerobic adhesives, and both unseated assembly conditions. Five to ten samples are tested for each combination. Tests for initial use, reuse without additional adhesive, and reuse with additional adhesive are performed for all samples. A 48-hour cure time was used for all initial use and reuse tests. Test data are presented as removal torque versus removal angle with the specification required prevailing torque range added for performance assessment. Percent specification pass rates for the all combinations of fastener material, adhesive, and assembly condition are tabulated and reveal use of anaerobic adhesive as a prevailing torque locking feature is viable. Although not every possible fastener material and anaerobic adhesive combination provides prevailing torque values within specification, any combination can be assessed using the test procedures presented. Reuse without additional anaerobic adhesive generally provides some prevailing torque, and in some cases within specification. Reuse with additional adhesive often provides comparable removal torque data as in initial use.
Heidi R. Huber-Stearns; Drew E. Bennett; Stephen Posner; Ryan C. Richards; Jenn Hoyle. Fair; Stella J. M. Cousins; Chelsie L. Romulo
The concept of "enabling conditions" centers on conditions that facilitate approaches to addressing social and ecological challenges. Although multiple fields have independently addressed the concept of enabling conditions, the literature lacks a shared understanding or integration of concepts. We propose a more synthesized understanding of enabling conditions beyond disciplinary boundaries by focusing on the enabling conditions that influence the implementation of a range of environmental p...
Kayla P. Meek
Full Text Available Background: Social engagement is key to health and quality of life. Little is known about social engagement patterns of middle-aged and older adults who live with one or more chronic illnesses. This study investigated social engagement restrictions among middle-aged and older adults with chronic conditions and factors associated with these restrictions. Methods: Cross-sectional representative data from the National Council on Aging Chronic Care Survey were examined for relationships between social engagement restrictions and chronic conditions, health status, support, quality of life implications, self-care barriers, caregiving, and demographics. Associations were tested using bivariate analyses and binary logistic regression. Results: Participants were 793 middle-aged (age 44–64 and older adults (age 65+ with one or more chronic conditions. Factors associated with social engagement restrictions included having higher education, receiving care, having more physician visits and hospitalizations, being disabled, being unemployed, and having higher Emotional and Physical Problems Scale scores. Conclusions: Findings reveal the prevalence of social engagement restrictions among middle-aged and older adults with chronic conditions. Results highlight the importance of promoting research, assessments, and interventions to increase social engagement among this aging population.
Full Text Available Social communication is heavily affected in patients with neuropsychiatric disorders. Accordingly, mouse models designed to study the mechanisms leading to these disorders are tested for this phenotypic trait. Test conditions vary between different models, and the effect of these test conditions on the quantity and quality of social interactions and ultrasonic communication is unknown. The present study examines to which extent the habituation time to the test cage as well as the shape/size of the cage influence social communication in freely interacting mice. We tested 8 pairs of male mice in free dyadic social interactions, with two habituation times (20 min and 30 min and three cage formats (rectangle, round, square. We tested the effect of these conditions on the different types of social contacts, approach-escape sequences, follow behavior, and the time each animal spent in the vision field of the other one, as well as on the emission of ultrasonic vocalizations and their contexts of emission. We provide for the first time an integrated analysis of the social interaction behavior and ultrasonic vocalizations. Surprisingly, we did not highlight any significant effect of habituation time and cage shape/size on the behavioral events examined. There was only a slight increase of social interactions with the longer habituation time in the round cage. Remarkably, we also showed that vocalizations were emitted during specific behavioral sequences especially during close contact or approach behaviors. The present study provides a protocol reliably eliciting social contacts and ultrasonic vocalizations in adult male mice. This protocol is therefore well adapted for standardized investigation of social interactions in mouse models of neuropsychiatric disorders.
Social capital is often claimed to be promoted by stable social structures such as low migration rates between neighbourhoods and social networks that remain stable over time. However, stable social structures may also inhibit the formation of social capital in the form of social networks and social participation. One example is psychosocial conditions at work, which may be determined by characteristics such as demand and control in the work situation. The study examines the active workforce subpopulation within the Swedish Malmö Shoulder Neck Study. A total of 7836 individuals aged 45-69 years, were interviewed at baseline between 1992 and 1994, and at a 1-year follow-up. Four groups of baseline psychosocial work conditions categories defined by the Karasek-Theorell model (jobstrain, passive, active, relaxed) were analysed according to 13 different social participation items during the past year reported at the 1-year follow-up. Odds ratios and 95% confidence intervals with the jobstrain group as a reference were estimated. A multivariate logistic regression model was used to assess differences in different aspects of social participation between the four psychosocial work conditions groups. The results show that the respondents within the active category in particular but also the relaxed category, have significantly higher participation in many of the 13 social participation items, even after multivariate adjustments. The results strongly suggest that psychosocial work conditions may be an important determinant of social capital measured as social participation, a finding of immediate public health relevance because of the well known positive association between social participation and health-related behaviours.
Kane, Jennifer B; Margerison-Zilko, Claire
Recent efforts to explain the stark social and racial disparities in adverse birth outcomes that have persisted for decades in the U.S. have looked beyond prenatal factors, to explore preconception social conditions that may influence perinatal health via dysregulation of physiologic processes. The extant evidence supporting this link however remains limited, both due to a lack of data and theory. To address the latter, this manuscript generates a structured set of theoretical insights that further develop the link between two preconception social conditions - place and social relationships - and perinatal health. The insights propose the following. necessarily encompasses all social contexts to which females are exposed from infancy through young adulthood; encompasses a variety of related exposures that, when possible, should be jointly considered; and may compound the effect of poverty-in childhood, adolescence, or young adulthood-on perinatal health. Social relationships: span relationships from early life through adulthood, and extend to intergenerational associations; often involve (or induce) major changes in the lives of individuals and should be examined with an emphasis on the developmental stage in which the change occurred; and necessarily encompass a lack of social integration, or, social isolation. We also identify potential biological and social-structural mechanisms linking these preconception social conditions to perinatal health, and conclude by identifying promising directions for future research.
It is well documented that exposure to chronic negative working conditions leads to stress. This subsequently impacts sickness absence and attrition, making it a key consideration for policymakers and academics alike. This study therefore seeks to investigate the influence of psychosocial working conditions on stress and related outcomes: sickness presenteeism, job satisfaction, and turnover intentions in UK social workers (SWs). A cross-sectional survey was used, in addition to a single open...
Heidi R. Huber-Stearns
Full Text Available The concept of "enabling conditions" centers on conditions that facilitate approaches to addressing social and ecological challenges. Although multiple fields have independently addressed the concept of enabling conditions, the literature lacks a shared understanding or integration of concepts. We propose a more synthesized understanding of enabling conditions beyond disciplinary boundaries by focusing on the enabling conditions that influence the implementation of a range of environmental policies termed payments for ecosystem services (PES. Through an analysis of key literature from different disciplinary perspectives, we examined how researchers and practitioners refer to and identify enabling conditions within the context of PES. Through our synthesis, we identified 24 distinct enabling conditions organized within 4 broad themes: biophysical, economic, governance, and social-cultural conditions. We found that the literature coalesces around certain enabling conditions, such as strong ecosystem science and existing institutions, regardless of disciplinary background or journal audience. We also observed key differences in how authors perceive the direction of influence for property type, program objectives, and number of actors. Additionally, we noted an emphasis on the importance of the contextual nature of many enabling conditions that may cause certain conditions to have a disproportionate impact on successful implementation in some circumstances. Unraveling the relative importance of specific enabling conditions in diverse contexts remains a research frontier. Ultimately, no single disciplinary perspective is likely to provide all necessary insights for PES creation, and given the intertwined nature of enabling conditions, practitioners need to consider insights from multiple dimensions. Our work suggests opportunities to better connect diverse conversations through integration of concepts, a common vocabulary, and a synthetic framework.
Ji, Xiang; Ae Chun, Soon; Geller, James
Many patients suffer from comorbidity conditions, for example, obese patients often develop type-2 diabetes and hypertension. In the US, 80% of Medicare spending is for managing patients with these multiple coexisting conditions. Predicting potential comorbidity conditions for an individual patient can promote preventive care and reduce costs. Predicting possible comorbidity progression paths can provide important insights into population heath and aid with decisions in public health policies. Discovering the comorbidity relationships is complex and difficult, due to limited access to Electronic Health Records by privacy laws. In this paper, we present a collaborative comorbidity prediction method to predict likely comorbid conditions for individual patients, and a trajectory prediction graph model to reveal progression paths of comorbid conditions. Our prediction approaches utilize patient generated health reports on online social media, called Social Health Records (SHR). The experimental results based on one SHR source show that our method is able to predict future comorbid conditions for a patient with coverage values of 48% and 75% for a top-20 and a top-100 ranked list, respectively. For risk trajectory prediction, our approach is able to reveal each potential progression trajectory between any two conditions and infer the confidence of the future trajectory, given any observed condition. The predicted trajectories are validated with existing comorbidity relations from the medical literature.
Martin, Loren; Iceberg, Erica
In this protocol, social motivation is measured in mice through a pair of operant conditioning paradigms. To conduct the experiments, two-chambered shuttle boxes were equipped with two operant levers (left and right) and a food receptacle in one chamber, which was then divided from the second chamber by an automated guillotine door covered by a wire grid. Different stimulus mice, rotated across testing days, served as a social stimulus behind the wire grid, and were only visible following the opening of the guillotine door. Test mice were trained to lever press in order to open the door and gain access to the stimulus partner for 15 sec. The number of lever presses required to obtain the social reward progressively increased on a fixed schedule of 3. Testing sessions ended after test mice stopped lever pressing for 5 consecutive minutes. The last reinforced ratio or breakpoint can be used as a quantitative measure of social motivation. For the second paradigm, test mice were trained to discriminate between left and right lever presses in order to obtain either a food reward or the social reward. Mice were rewarded for every 3 presses of each respective lever. The number of food and social rewards can be compared as a measurement of the value placed upon each reward. The ratio of each reward type can also be compared between mouse strains and the change in this ratio can be monitored within testing sessions to measure satiation with a given reward type. Both of these operant conditioning paradigms are highly useful for the quantification of social motivation in mouse models of autism and other disorders of social behavior.
Full Text Available Entrepreneurship is a complex phenomenon that involves not only economic activity but also social mechanisms. The intention to become an entrepreneur is a matter not only of one’s individual personality but also of one's interaction with the social environment. This study has three main objectives: predicting the existence of entrepreneurial behavioural intentions in different socio-economic conditions; examining how entrepreneurial behavioural intentions formulate entrepreneurial behaviour; and identifying how social capital influences this relationship. It also aims to reveal the differences between entrepreneurs in a relatively mature free market economy (Taiwan and a newly emerging free market economy (Mongolia. The analysis shows that socio-economic conditions affect the formation of entrepreneurial intentions. There are different approaches to building social capital in a relatively mature market and its newly emerging counterpart. The tendency of having high trust and social ties was found in Taiwanese entrepreneurs, while monitoring is commonly found among Mongolian entrepreneurs.
Alan E. Watson
âSocial conditions in wildernessâ refers to all aspects of human use of the wilderness that pose the possibility of impact to the resource and visitor experiences. The reasons for monitoring (1) use levels and use trends (including characteristics of use and users) and (2) the quality of the recreation experiences provided (ability to provide naturalness, privacy, and...
A social investigation was performed of 74 patients with temporal lobe epilepsy resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. The patients were compared to their sibilings and to the general population in Denmark. Comparatively many patients were born out of wedlock. The level of schooling achieved was lower than expected, and this was most pronounced in patients with an early onset of epilepsy. The number of patients having received further education was also smaller than calculated. At the time of the operation all patients were socially incapacitated by their epilepsy; this was most pronounced in males, of whom 30 per cent were institutionalized and 32 per cent were receiving disablement pension; at follow-up the figures were 6 per cent and 52 per cent, respectively. Working capacity was markedly improved postoperatively, and at follow-up 39 per cent were in full-time employment. Relief from seizures (or almost complete relief), normal intelligence, normal psychiatric status, and operation before the age of 18 years were factors which favourably influenced the postoperative working capacity. The majority of the patients were unmarried or divorced, and few of the group had children. Their housing conditions were inferior to those of their siblings and of the general population. Parental social class distribution showed an excess in the highest and lowest social classes compared to the Danish population. The patients were subjected to downward social mobility, presumably caused by their illness, as their siblings displayed an upward mobility, which was most marked in the females.
Maksimova, T M; Gaenko, O N; Belov, V B
Results of social-and-hygienic research of the health condition of children belonging to different social-and-economic population categories are under discussion. The material family status is shown to directly affect the child's life quality, i.e. family life mode, psychological climate, scope and variety of food-stuffs, the possibility to have a regular and valuable recreation, educational regime, and the possibility to satisfy the spiritual demands of a child etc. The morbidity goes up among children as the family income decreases. The social-and-economic conditions are the uttermost and often decisive risk factor that provokes the development of deviations in children's health. The material stratification of society conditions, for children, differing degrees of access to public benefits that are involved in shaping the children's health, thus, entailing the disequilibrium in their health. A realistic pattern of children's health is needed as a data base to define an objective necessity of children in medical care of different types as well as their necessity in medical drugs and equipment.
Hu, Yanqing; Havlin, Shlomo; Makse, Hernán A.
A fundamental problem in network science is to predict how certain individuals are able to initiate new networks to spring up "new ideas." Frequently, these changes in trends are triggered by a few innovators who rapidly impose their ideas through "viral" influence spreading, producing cascades of followers and fragmenting an old network to create a new one. Typical examples include the rise of scientific ideas or abrupt changes in social media, like the rise of Facebook to the detriment of Myspace. How this process arises in practice has not been conclusively demonstrated. Here, we show that a condition for sustaining a viral spreading process is the existence of a multiplex-correlated graph with hidden "influence links." Analytical solutions predict percolation-phase transitions, either abrupt or continuous, where networks are disintegrated through viral cascades of followers, as in empirical data. Our modeling predicts the strict conditions to sustain a large viral spreading via a scaling form of the local correlation function between multilayers, which we also confirm empirically. Ultimately, the theory predicts the conditions for viral cascading in a large class of multiplex networks ranging from social to financial systems and markets.
Office of Personnel Management — Annual reports of the Federal Prevailing Rate Advisory Committee (FPRAC), which studies the prevailing (market) rate system for wages and other matters pertinent to...
'Full text:'In this paper, results of a comprehensive water mass balance modeling for the Great Lakes against prevailing and different anticipated climate change scenarios would be presented. Modeling is done in evaluating the changes in the lake storages and then changes in the lake's water level considering present condition, uncertainty and variability of climate and hydrologic conditions in the future. Inflow-outflow and consequent changes in the five Great Lake's storages are simulated for the last 30 years and then projected to evaluate the changes in the lake storages for the next 50 years. From the predicted changes in the lake storage data, water level is calculated using mass to linear conversion equation. Modeling and analysis results are expected to be helpful in understanding the possible impacts of the climate change on the Great Lakes water environment and preparing strategic plan for the sustainable management of lake's water resources. From the recent past, it is observed that there is a depleting trend in the lakes water level and hence there is a potential threat to lake's water environment and uncertainty of the availability of quality and quantity of water for the future generations, especially against prevailing and anticipated climate changes. For this reason, it is an urgent issue of understanding and quantifying the potential impacts of climate change on the Great Lake's water levels and storages. (author)
... 29 Labor 3 2010-07-01 2010-07-01 false Prevailing minimum compensation. 505.3 Section 505.3 Labor... HUMANITIES § 505.3 Prevailing minimum compensation. (a)(1) In the absence of an alternative determination...)(2) of this section, the prevailing minimum compensation required to be paid under the Act to the...
... 29 Labor 1 2010-07-01 2010-07-01 true Prevailing in the locality determinations. 4.51 Section 4.51... Procedures § 4.51 Prevailing in the locality determinations. (a) Information considered. The minimum monetary... benefits contained in collective bargaining agreements where they have been determined to prevail in a...
... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Prevailing party. 301.7430-5 Section 301.7430-5... Prevailing party. (a) In general. For purposes of an award of reasonable administrative costs under section... prevailing party only if— (1) The position of the Internal Revenue Service was not substantially justified...
Simons, Ronald L.; Burt, Callie Harbin
In this paper we develop and test a new approach to explain the link between social factors and individual offending. We argue that seemingly disparate family, peer, and community conditions lead to crime because the lessons communicated by these events are similar and promote social schemas involving a hostile view of people and relationships, a preference for immediate rewards, and a cynical view of conventional norms. Further, we posit that these three schemas are interconnected and combine to form a criminogenic knowledge structure that gives rise to situational interpretations legitimating criminal behavior. Structural equation modeling with a sample of roughly 700 hundred African American teens provided strong support for the model. The findings indicated that persistent exposure to adverse conditions such as community crime, discrimination, harsh parenting, deviant peers and low neighborhood collective efficacy increased commitment to the three social schemas. The three schemas were highly intercorrelated and combined to form a latent construct that strongly predicted increases in crime. Further, in large measure the effect of the various adverse conditions on increases in crime was indirect through their impact on this latent construct. We discuss the extent to which the social schematic model presented in the paper might be used to integrate concepts and findings from several of the major theories of criminal behavior. PMID:21760641
Hyun Jung Cho
Full Text Available Estuarine waters are generally more turbid than lakes or marine waters due to greater algal mass and continual re-suspension of sediments. The varying effects of diurnal and seasonal prevailing winds on the turbidity condition of a wind-dominated estuary were investigated by spatial and statistical analyses of wind direction, water level, turbidity, chlorophyll a, and PAR (Photosynthetically Active Radiation collected in Lake Pontchartrain, Louisiana, USA. The prolonged prevailing winds were responsible for the long-term, large-scale turbidity pattern of the estuary, whereas the short-term changes in wind direction had differential effects on turbidity and water level in varying locations. There were temporal and spatial changes in the relationship between vertical light attenuation coefficient (Kd and turbidity, which indicate difference in phytoplankton and color also affect Kd. This study demonstrates that the effect of wind on turbidity and water level on different shores can be identified through system-specific analyses of turbidity patterns.
Yates, Justin R; Beckmann, Joshua S; Meyer, Andrew C; Bardo, Michael T
Social interaction can serve as a natural reward that attenuates drug reward in rats; however, it is unknown if age or housing conditions alter the choice between social interaction and drug. Individually- and pair-housed adolescent and adult male rats were tested using conditioned place preference (CPP) in separate experiments in which: (1) social interaction was conditioned against no social interaction; (2) amphetamine (AMPH; 1mg/kg, s.c.) was conditioned against saline; or (3) social interaction was conditioned against AMPH. Social interaction CPP was obtained only in individually-housed adolescents, whereas AMPH CPP was obtained in both individually-housed adolescents and adults; however, the effect of AMPH was not statistically significant in pair-housed adults. When allowed to choose concurrently between compartments paired with either social interaction or AMPH, individually-housed adolescents preferred the compartment paired with social interaction, whereas pair-housed adolescents preferred the compartment paired with AMPH. Regardless of housing condition, adults showed a similar preference for the compartments paired with either social interaction or AMPH. Although some caution is needed in interpreting cross-experiment comparisons, the overall results suggest that individually-housed adolescents were most sensitive to the rewarding effect of social interaction, and this hypersensitivity to social reward effectively competed with AMPH reward. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
O'Neill, M.S.; Loomis, Dana; Borja-Aburto, V.H.
We investigated whether the association of daily mortality and ambient ozone differs by age and area social conditions of the region of residence using a time-series analysis. The study setting was metropolitan Mexico City, a high altitude city situated in a valley, with an estimated 20 million inhabitants, large socioeconomic gradients, and ozone levels frequently exceeding international standards. We stratified daily deaths by six census-derived socioeconomic indicators, based on characteristics of the county where decedents lived. We used Poisson regression to model the association between daily mortality and ozone levels (on the day of death and the previous day) in separate models, stratified by area socioeconomic level and age, and controlling for time trends and temperature. Ozone was positively associated with total mortality [0.65% increase per 10 ppb increment, 95% confidence interval (CI): 0.02%, 1.28%] and for mortality among those over age 65 [1.39% increase per 10 ppb increment, 95% CI: 0.51%, 2.28%]. Associations between ozone and all-age mortality did not show any consistent patterns according to socioeconomic gradients. We conclude that elderly people are at higher risk for ozone-associated mortality. Though county-level social indicators in Mexico City were not strong markers of vulnerability to ozone-associated acute mortality in this analysis, complex associations between individual and area-level factors may exist that would require additional data and further analyses to elucidate
Liedtke, J; Schneider, J M
There is a long-standing debate as to whether social or physical environmental aspects drive the evolution and development of cognitive abilities. Surprisingly few studies make use of developmental plasticity to compare the effects of these two domains during development on behaviour later in life. Here, we present rearing effects on the development of learning abilities and social behaviour in the jumping spider Marpissa muscosa. These spiders are ideally suited for this purpose because they possess the ability to learn and can be reared in groups but also in isolation without added stress. This is a critical but rarely met requirement for experimentally varying the social environment to test its impact on cognition. We split broods of spiders and reared them either in a physically or in a socially enriched environment. A third group kept under completely deprived conditions served as a 'no-enrichment' control. We tested the spiders' learning abilities by using a modified T-maze. Social behaviour was investigated by confronting spiders with their own mirror image. Results show that spiders reared in groups outperform their conspecifics from the control, i.e. 'no-enrichment', group in both tasks. Physical enrichment did not lead to such an increased performance. We therefore tentatively suggest that growing up in contact with conspecifics induces the development of cognitive abilities in this species.
Cook, Jennifer L.; Bird, Geoffrey
Appropriate modulation of imitation according to social context is important for successful social interaction. In the present study we subliminally primed high-functioning adults with ASC and age- and IQ-matched controls with either a pro- or non- social attitude. Following priming, an automatic imitation paradigm was used to acquire an index of…
Full Text Available This study assessed the influence of trait social anxiety on cardiovascular, emotional and behavioral responses to active performance situations representing social and cognitive demands. Thirty-six male and thirty-six female students categorized as either high or low in trait social anxiety performed a mental arithmetic task and two interpersonal tasks requiring persuasive behavior: Preparation and Performance of a Speech, Role-played Interpersonal Interactions. The cardiovascular effects of social anxiety varied over experimental stressors and appear to reflect differences in effort or task engagement rather than differential affective experiences. During Role-played Interactions high socially anxious subjects displayed lower increases in systolic blood pressure compared to low anxious participants. This effect was partially mediated by behavioral indicators of social competence and suggests a more inhibited coping approach of socially anxious participants. Findings for Mental Arithmetic were in the opposite direction, high socially anxious subjects displayed greater heart rate effects. In the absence of group differences in state anxiety this effect might result from stronger audience effects on effort or task motivation in socially anxious participants. These findings strengthen the view that active performance situations elicit cardiovascular effects that are largely attributable to differences in task engagement. The data also indicate the importance of considering situational factors in social anxiety research.
Klausen, Susanne Hwiid; Mikkelsen, Ulla Ramer; Hirth, Asle
to participate in physical activity are in the process of being enrolled by invitation after informed consent. Physical fitness is measured as the maximal oxygen uptake (Vo(2)) at baseline and after 12 months by an assessor blinded to the randomization group. After baseline testing, the patients are 1......:1 randomized to an intervention group or a control group. Individually fully automated tailored e-Health encouragements--SMS, Internet, and mobile applications--aimed at increasing physical activity are delivered to the participants in the intervention group once a week. The Bandura's Social Cognitive Theory...
... 29 Labor 3 2010-07-01 2010-07-01 false Prevailing wage rates. 525.10 Section 525.10 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS EMPLOYMENT OF WORKERS WITH DISABILITIES UNDER SPECIAL CERTIFICATES § 525.10 Prevailing wage rates. (a) A...
S. Gloppen (Siri)
textabstractThis article commends the concise and useful analysis of courts and the legal enforcement of economic, social and cultural rights given in Christian Courtis’ book, Courts and the Legal Enforcement of Economic, Social and Cultural Rights: Comparative Experiences of Justiciability. Yet, in
Full Text Available The paper analyses the topic of social dualism through religion, morality and science. The paper refers to one of the most original works uncovering the social roots of religion – The Elementary Forms of the Religious Life by Emile Durkheim (1858–1917 who is considered to be the founder of modern sociology. The Elementary Forms of the Religious Life develops the coherent theory of religion as well as ventilates different aspects of the religious life. The message of the paper is: is religion the generative essence of social aspect, does a state of constant dependence stimulate a sense of religious piety, is a moral social order able to stabilize dualism of human energy. The paper proposes an assertion that science as a social phenomenon reflects knowledge and the values of its perception which are impacted by imagination and classified codes of cultural forms. As a result a thesis is proposed – a cultural (influenced by environment and a personal (influenced by internal factors desire for differentiation and its provoked conflict is of a social character. The second part of the paper deals with relation between science and social phenomena with inherent dualism. A short discussion is presented on L’ Année Sociologique (a group of scientists initiated by Durkheim representing a new sociological paradigm, the beginning of scientific social culture giving sense to cooperation of sociological theory and practice.
Søndergaard, Eva; Jensen, Margit Bak; Nicol, Christine J.
and muzzle contact, respectively, to a familiar companion horse. Horses were housed individually next to their companion horse and separations between pens prevented physical contact. During daily test sessions horses were brought to a test area where they could access an arena allowing social contact. Arena......Although horses are social animals they are often housed individually with limited social contact to other horses and this may compromise their welfare. The present study included eight young female horses and investigated the strength of motivation for access to full social contact, head contact...... test session was recorded. All horses could access all three types of social contact in a cross-over design, and an empty arena was used as control. Motivational strength was assessed using elasticity of demand functions, which were estimated based on the number of rewards earned and FR. Elasticities...
Munoz, P; Kibler, E
This paper deals with the impact of local institutional conditions on the formation of opportunity feasibility beliefs in social entrepreneurship. Embedded in the recent literature on entrepreneurial cognitions, institutions and social entrepreneurship, this study provides a systematic analysis of 776 social entrepreneurs in the UK to identify combinations of causal institutional conditions that collectively explain how early-stage social entrepreneurs form beliefs of feasibility regarding th...
Beckes, Lane; Coan, James A; Morris, James P
Not much is known about the neural and psychological processes that promote the initial conditions necessary for positive social bonding. This study explores one method of conditioned bonding utilizing dynamics related to the social regulation of emotion and attachment theory. This form of conditioning involves repeated presentations of negative stimuli followed by images of warm, smiling faces. L. Beckes, J. Simpson, and A. Erickson (2010) found that this conditioning procedure results in positive associations with the faces measured via a lexical decision task, suggesting they are perceived as comforting. This study found that the P1 ERP was similarly modified by this conditioning procedure and the P1 amplitude predicted lexical decision times to insecure words primed by the faces. The findings have implications for understanding how the brain detects supportive people, the flexibility and modifiability of early ERP components, and social bonding more broadly. Copyright © 2013 Society for Psychophysiological Research.
Figueroa, Maria J.
stream of innovation in sharing space for bicycling of the four cities. The case of Copenhagen demonstrates effectively the unlocking force toward social change that can be in great part linked to the forceful narratives and claims presented by actors or generated in the actors’ interplay. It also...... to deepen the analysis taking departure from this empirical work contributing to the discussion of how these practices of social innovation to share space succeed (or failed) in introducing new societal values and norms and creating ‘new imaginaries’ for progressive social and environmental change; also how...... to analyze to what extent these social innovative practices could be seen as extending (or not) ‘coping mechanisms’ for socio-economic exclusion in times of austerity, demographic changes and environmental crisis of the late capitalistic societies....
Christoffersen, Mogens; Azhar, Hussain
The study investigates the economic, ethnic and social background of teenagers before becoming teenage mothers or before having an induced abortion for the first time in order to study if results will be consistent with the hypotheses that poverty, social deprivation or ethnicity are causes of teen...... were at the same level for ethnic minorities as for ethnic Danes, this was not the case for teen motherhood, when controlling for social disadvantage and poverty....... childbearing. A discrete-time proportional hazard model is applied to analyse the longitudinal observations of population-based registers covering 1981-2003 for girls born in 1981, and their parents. Results show a significant economic and social gradient for first-time teenage pregnancies. Teenagers who had...
A case for 'prevailing ecology' as premium determinant in home-based child care ... Ewe mothers located in Dzemeni a migrant, lakeside community in Ghana. ... It builds a case from the analysis of definitions and concepts in care literature.
Poulin-Charronnat, Bénédicte; Perruchet, Pierre; Tillmann, Barbara; Peereman, Ronald
In language acquisition research, the prevailing position is that listeners exploit statistical cues, in particular transitional probabilities between syllables, to discover words of a language. However, other cues are also involved in word discovery. Assessing the weight learners give to these different cues leads to a better understanding of the processes underlying speech segmentation. The present study evaluated whether adult learners preferentially used known units or statistical cues for segmenting continuous speech. Before the exposure phase, participants were familiarized with part-words of a three-word artificial language. This design allowed the dissociation of the influence of statistical cues and familiar units, with statistical cues favoring word segmentation and familiar units favoring (nonoptimal) part-word segmentation. In Experiment 1, performance in a two-alternative forced choice (2AFC) task between words and part-words revealed part-word segmentation (even though part-words were less cohesive in terms of transitional probabilities and less frequent than words). By contrast, an unfamiliarized group exhibited word segmentation, as usually observed in standard conditions. Experiment 2 used a syllable-detection task to remove the likely contamination of performance by memory and strategy effects in the 2AFC task. Overall, the results suggest that familiar units overrode statistical cues, ultimately questioning the need for computation mechanisms of transitional probabilities (TPs) in natural language speech segmentation.
Meyer, John W.
The effects of a school on diffuse attributes of students such as their values are seen as produced by the wider social definition of the products of the school--here called its "charter". Schools or systems of schools which are chartered to confer major status gains and entry into diffusely-defined elites are seen as more likely to have broad…
Urban marginal territories with similar levels of social exclusion might present di erent degrees of violence because of di erences in the capacity of the community to act to confront the phenomenon of violence. Research questions. Hypothesis. The research was carried out in. Outputs. Methodology. Household survey.
Houtman, I.L.D.; Kwantes, J.H.; Brugman, T.
There is a bi-annual study performed by the Ministry of Social Affairs and Employment which makes an inventory on the topics covered by Collective Agreements (CA's). Agreements on violence, intimidation and harassment, as well as psychosocial work load in general are most prevalent. Agreements on
Zoicas, Iulia; Slattery, David A; Neumann, Inga D
Central oxytocin (OXT) has anxiolytic and pro-social properties both in humans and rodents, and has been proposed as a therapeutic option for anxiety and social dysfunctions. Here, we utilized a mouse model of social fear conditioning (SFC) to study the effects of OXT on social fear, and to determine whether SFC causes alterations in central OXT receptor (OXTR) binding and local OXT release. Central infusion of OXT, but not arginine vasopressin, prior to social fear extinction training completely abolished social fear expression in an OXTR-mediated fashion without affecting general anxiety or locomotion. SFC caused increased OXTR binding in the dorso-lateral septum (DLS), central amygdala, dentate gyrus, and cornu ammunis 1, which normalized after social fear extinction, suggesting that these areas form part of a brain network involved in the development and neural support of social fear. Microdialysis revealed that the increase in OXT release observed in unconditioned mice within the DLS during social fear extinction training was attenuated in conditioned mice. Consequently, increasing the availability of local OXT by infusion of OXT into the DLS reversed social fear. Thus, alterations in the brain OXT system, including altered OXTR binding and OXT release within the DLS, play an important role in SFC and social fear extinction. Thus, we suggest that the OXT system is adversely affected in disorders associated with social fear, such as social anxiety disorder and reinstalling an appropriate balance of the OXT system may alleviate some of the symptoms.
Feng, Ling; Hu, Yanqing; Li, Baowen; Stanley, H Eugene; Havlin, Shlomo; Braunstein, Lidia A
Modern social media are becoming overloaded with information because of the rapidly-expanding number of information feeds. We analyze the user-generated content in Sina Weibo, and find evidence that the spread of popular messages often follow a mechanism that differs from the spread of disease, in contrast to common belief. In this mechanism, an individual with more friends needs more repeated exposures to spread further the information. Moreover, our data suggest that for certain messages the chance of an individual to share the message is proportional to the fraction of its neighbours who shared it with him/her, which is a result of competition for attention. We model this process using a fractional susceptible infected recovered (FSIR) model, where the infection probability of a node is proportional to its fraction of infected neighbors. Our findings have dramatic implications for information contagion. For example, using the FSIR model we find that real-world social networks have a finite epidemic threshold in contrast to the zero threshold in disease epidemic models. This means that when individuals are overloaded with excess information feeds, the information either reaches out the population if it is above the critical epidemic threshold, or it would never be well received.
Full Text Available Modern social media are becoming overloaded with information because of the rapidly-expanding number of information feeds. We analyze the user-generated content in Sina Weibo, and find evidence that the spread of popular messages often follow a mechanism that differs from the spread of disease, in contrast to common belief. In this mechanism, an individual with more friends needs more repeated exposures to spread further the information. Moreover, our data suggest that for certain messages the chance of an individual to share the message is proportional to the fraction of its neighbours who shared it with him/her, which is a result of competition for attention. We model this process using a fractional susceptible infected recovered (FSIR model, where the infection probability of a node is proportional to its fraction of infected neighbors. Our findings have dramatic implications for information contagion. For example, using the FSIR model we find that real-world social networks have a finite epidemic threshold in contrast to the zero threshold in disease epidemic models. This means that when individuals are overloaded with excess information feeds, the information either reaches out the population if it is above the critical epidemic threshold, or it would never be well received.
Full Text Available BACKGROUND: We study the evolutionary Prisoner's Dilemma on two social networks substrates obtained from actual relational data. METHODOLOGY/PRINCIPAL FINDINGS: We find very different cooperation levels on each of them that cannot be easily understood in terms of global statistical properties of both networks. We claim that the result can be understood at the mesoscopic scale, by studying the community structure of the networks. We explain the dependence of the cooperation level on the temptation parameter in terms of the internal structure of the communities and their interconnections. We then test our results on community-structured, specifically designed artificial networks, finding a good agreement with the observations in both real substrates. CONCLUSION: Our results support the conclusion that studies of evolutionary games on model networks and their interpretation in terms of global properties may not be sufficient to study specific, real social systems. Further, the study allows us to define new quantitative parameters that summarize the mesoscopic structure of any network. In addition, the community perspective may be helpful to interpret the origin and behavior of existing networks as well as to design structures that show resilient cooperative behavior.
Lozano, S.; Arenas, A.; Sanchez, A.
We study the evolutionary Prisoner's Dilemma on two social networks substrates obtained from actual relational data. We find very different cooperation levels on each of them that cannot be easily understood in terms of global statistical properties of both networks. We claim that the result can be understood at the mesoscopic scale, by studying the community structure of the networks. We explain the dependence of the cooperation level on the temptation parameter in terms of the internal structure of the communities and their interconnections. We then test our results on community-structured, specifically designed artificial networks, finding a good agreement with the observations in both real substrates. Our results support the conclusion that studies of evolutionary games on model networks and their interpretation in terms of global properties may not be sufficient to study specific, real social systems. Further, the study allows us to define new quantitative parameters that summarize the mesoscopic structure of any network. In addition, the community perspective may be helpful to interpret the origin and behavior of existing networks as well as to design structures that show resilient cooperative behavior.
Gómez, Carmen; Redolat, Rosa; Carrasco, Carmen
The antidepressant bupropion has received increasing attention as a pharmacological tool to treat addiction although little is known about its effects on social behaviour in adolescents. The present study aimed to evaluate if environmental housing conditions influence bupropion's actions on social behaviour of adolescent mice. Mice were either group- or individually housed for 2-weeks and then randomly divided into 2 cohorts: half of the mice remained in the initial housing condition and the other half were changed to isolated conditions for further 2-weeks. The following groups were compared: isolated/isolated (ISO/ISO), isolated/group-housed (ISO/GR), group-housed/isolated (GR/ISO), and group-housed/group-housed (GR/GR). The effects of bupropion (40, 20, 10mg/kg) or saline on social interaction were assessed for each housing condition. Social encounters were evaluated using ethological analysis. Data showed significant effects of bupropion on grooming and digging. This drug diminished time mice allocated to these behavioural categories in all housing conditions. In ISO/GR and GR/ISO conditions, bupropion increased environmental exploration (non-social exploration and exploration from a distance), reduced social investigation and increased avoidance/flee and defence/submission behaviours. An augment of avoidance/flee during social interactions was observed in bupropion-treated mice in GR/GR housing condition. These results suggest that this drug exhibits anxiogenic-like properties in social encounters between adolescent mice, especially when a transition in housing conditions has been experienced during this period. Changes in housing conditions may be a useful model for evaluating the effects of bupropion on social behaviour and the role of environmental housing conditions. Copyright © 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
Hobfoll, Stevan E; Blais, Rebecca K; Stevens, Natalie R; Walt, Lisa; Gengler, Richard
Despite heightened rates of depression and posttraumatic stress disorder (PTSD) among in Iraq/Afghanistan veterans, the majority of distressed veterans will not receive mental health care. Overcoming barriers to mental health services requires innovative approaches to broaden the reach of evidence-based treatment. The current study examined the efficacy and acceptability of an innovative and dynamic online cognitive-behavioral therapy intervention for PTSD and depression called Vets Prevail. A randomized clinical trial conducted between 2011 and 2013 assessed changes in PTSD and depression in veterans with mild-to-moderate distress. Veterans randomized to Vets Prevail (n = 209) were aged 34.2 ± 7.6 years, mostly male (81.3%), and nonminority (73.7%). Veterans randomized to adjustment as usual (n = 94) were aged 34.7 ± 8.9, mostly male (81.9%), and White (67.0%). Veterans completed the PTSD Checklist-Military Version and the Center for Epidemiological Studies Depression scale (10-item version) postintervention and at 12-week follow-up. Veterans in the Vets Prevail condition reported significantly greater reductions in PTSD, t(250) = 3.24, p = .001 (Mreduction = 5.51, SD = 9.63), and depression, t(252) = 4.37, p = .001 (Mreduction = 2.31, SD = 5.34), at 12-week follow-up compared with veterans in the adjustment as usual condition (PTSD Mreduction = 1.00, SD = 7.32; depression Mreduction = 0.48, SD = 4.95), with moderate effect sizes for PTSD (Cohen's d = 0.42) and depression (Cohen's d = 0.56). Exploratory analysis shows that Vets Prevail may be effective regardless of combat trauma exposure, gender, and ethnic minority status. Vets Prevail circumvents many barriers to care and effectively addresses the dire mental health needs of veterans. (c) 2015 APA, all rights reserved).
Lugovtsova, Y A; Karnaukh, V N
To analyze the medical and social condition of 70 families having a member with multiple sclerosis of working age. We used the classification of types and kinds of families of chronically ill patients of working-age that included two sections - grouping families by health and social status. By medical condition, most families are assessed as dysfunctional II degree, by welfare as at risk families. Both health and social status of the family depends on a number of social factors as well as the clinical characteristics of the disease, in particular, type of disease course and severity of neurological deficit.
Pfeiffer, Hans C.
PREVAIL - Projection Reduction Exposure with Variable Axis Immersion Lenses represents the high throughput e-beam projection approach to NGL which IBM is pursuing in cooperation with Nikon Corporation as alliance partner. This paper discusses the challenges and accomplishments of the PREVAIL project. The supreme challenge facing all e-beam lithography approaches has been and still is throughput. Since the throughput of e-beam projection systems is severely limited by the available optical field size, the key to success is the ability to overcome this limitation. The PREVAIL technique overcomes field-limiting off-axis aberrations through the use of variable axis lenses, which electronically shift the optical axis simultaneously with the deflected beam so that the beam effectively remains on axis. The resist images obtained with the Proof-of-Concept (POC) system demonstrate that PREVAIL effectively eliminates off- axis aberrations affecting both resolution and placement accuracy of pixels. As part of the POC system a high emittance gun has been developed to provide uniform illumination of the patterned subfield and to fill the large numerical aperture projection optics designed to significantly reduce beam blur caused by Coulomb interaction.
Leschke, Janine; Jepsen, Maria
and analysing the corresponding position of women and men in paid and unpaid work, the paper contains an in-depth discussion of the short- and medium-term policy responses to the crisis. Our analysis shows that independent of the prevailing gender regime, scant public attention has been directed to gender...
Soto, Sandra; Arredondo, Elva M; Villodas, Miguel T; Elder, John P; Quintanar, Elena; Madanat, Hala
The purpose of this study was to examine the "buffering hypothesis" of social network characteristics in the association between chronic conditions and depression among Latinos. Cross-sectional self-report data from the San Diego Prevention Research Center's community survey of Latinos were used (n = 393). Separate multiple logistic regression models tested the role of chronic conditions and social network characteristics in the likelihood of moderate-to-severe depressive symptoms. Having a greater proportion of the network comprised of friends increased the likelihood of depression among those with high cholesterol. Having a greater proportion of women in the social network was directly related to the increased likelihood of depression, regardless of the presence of chronic health conditions. Findings suggest that network characteristics may play a role in the link between chronic conditions and depression among Latinos. Future research should explore strategies targeting the social networks of Latinos to improve health outcomes.
Watts, Richard E.
Presents primary source documentation highlighting the similarities between Alfred Adler's social interest construct and the counselor-oriented core conditions of Carl Rogers. Implications of the similarities are discussed. (Author)
Kornreich, Charles; Delle-Vigne, Dyna; Knittel, Julian; Nerincx, Aurore; Campanella, Salvatore; Noel, Xavier; Hanak, Catherine; Verbanck, Paul; Ermer, Elsa
To study the 'social brain' in alcoholics by investigating social contract reasoning, theory of mind and emotional intelligence. A behavioral study comparing recently detoxified alcoholics with normal, healthy controls. Emotional intelligence and decoding of emotional non-verbal cues have been shown to be impaired in alcoholics. This study explores whether these deficits extend to conditional reasoning about social contracts. Twenty-five recently detoxified alcoholics (17 men and eight women) were compared with 25 normal controls (17 men and eight women) matched for sex, age and education level. Wason selection task investigating conditional reasoning on three different rule types (social contract, precautionary and descriptive), revised Reading the Mind in the Eyes Test, Trait Emotional Intelligence Questionnaire (modified version) and additional control measures. Conditional reasoning was impaired in alcoholics. Performance on descriptive rules was not above chance. Reasoning performance was markedly better on social contract and precautionary rules, but this performance was still significantly lower than in controls. Several emotional intelligence measures were lower in alcoholics compared to controls, but these were not correlated with reasoning performance. Conditional reasoning, including reasoning about social contracts and emotional intelligence appear to be impaired in alcoholics. Impairment seems to be particularly severe on descriptive rules. Impairment in social contract reasoning might lead to misunderstandings and frustration in social interactions, and reasoning difficulties about precautionary rules might contribute to risky behaviors in this population. © 2011 The Authors, Addiction © 2011 Society for the Study of Addiction.
Pronina A. N.
Formation of the high-grade person of children of preschool age, without parental support should be carried out in complete process of socialization-individualization that assumes working out of the pedagogical conditions directed on maintenance of interrelation of processes of socialization and an individualization.
Full Text Available The rock hyrax, Procavia capensis, is a highly social, diurnal mammal. In the current study several physiologically measurable parameters of sleep, as well as the accompanying behavior, were recorded continuously from five rock hyraxes, for 72 h under solitary (experimental animal alone in the recording chamber, and social conditions (experimental animal with 1 or 2 additional, non-implanted animals in the recording chamber. The results revealed no significant differences between solitary and social conditions for total sleep times, number of episodes, episode duration or slow wave activity (SWA for all states examined. The only significant difference observed between social and solitary conditions was the average duration of rapid eye movement (REM sleep episodes. REM sleep episode duration was on average 20 s and 40 s longer under social conditions daily and during the dark period, respectively. It is hypothesized that the increase in REM sleep episode duration under social conditions could possibly be attributed to improved thermoregulation strategies, however considering the limited sample size and design of the current study further investigations are needed to confirm this finding. Whether the conclusions and the observations made in this study can be generalized to all naturally socially sleeping mammals remains an open question.
Svetlana Sokolov Mladenovic, Djordje Cuzovic,
Under contemporary business conditions, market globalisation has become inevitable. Such relationships on the market make trade companies use different means to acquire and maintain long-term competitive advantage. One of them is the concept of corporate social responsibility, which is, under conditions of globalisation, seen as a redesign of the classic marketing concept. The aim of this paper is to highlight the development of corporate social responsibility in trade, in the context of mark...
The research is devoted to the problem of pedagogic-psychological accompaniment of the process of social adaptation of inmates of children's homes. Essence of pedagogic-psychological support as a special kind of professional activity to create conditions conducive to the successful adaptation of the inmates of children's homes in the community. Describes the set of psycho-pedagogical conditions, optimizing the process of social adaptation of inmates of children's homes.
El Rawas, Rana; Klement, Sabine; Kummer, Kai K; Fritz, Michael; Dechant, Georg; Saria, Alois; Zernig, Gerald
Positive social interaction could play an essential role in switching the preference of the substance dependent individual away from drug related activities. We have previously shown that conditioned place preference (CPP) for cocaine at the dose of 15 mg/kg and CPP for four 15-min episodes of social interaction were equally strong when rats were concurrently conditioned for place preference by pairing cocaine with one compartment and social interaction with the other. The aim of the present study was to investigate the differential activation of brain regions related to the reward circuitry after acquisition/expression of cocaine CPP or social interaction CPP. Our findings indicate that cocaine CPP and social interaction CPP activated almost the same brain regions. However, the granular insular cortex and the dorsal part of the agranular insular cortex were more activated after cocaine CPP, whereas the prelimbic cortex and the core subregion of the nucleus accumbens were more activated after social interaction CPP. These results suggest that the insular cortex appears to be potently activated after drug conditioning learning while activation of the prelimbic cortex-nucleus accumbens core projection seems to be preferentially involved in the conditioning to non-drug stimuli such as social interaction.
To investigate the associations between psychosocial conditions at work, social capital/social participation, and daily smoking. The 2000 public health survey in Scania is a cross sectional postal questionnaire study with a 59% participation rate. A total of 5180 persons aged 18-64 years that belonged to the work force and the unemployed were included in this study. Logistic regression models were used to investigate the associations between psychosocial factors at work/unemployment, social participation, and daily smoking. Psychosocial conditions at work were defined according to the Karasek-Theorell demand-control/decision latitudes into relaxed, active, passive, and jobstrain categories. The multivariate analyses included age, country of origin, education and economic stress. 17.2% proportion of all men and 21.9% of all women were daily smokers. The jobstrain (high demands/low control) and unemployed categories had significantly higher odds ratios of daily smoking among both men and women compared to the relaxed (low demands/high control) reference category. The passive (low demands/low control), jobstrain, and unemployed categories were also significantly associated with low social participation. Low social participation was significantly and positively associated with daily smoking within each of the psychosocial work conditions and unemployed categories. The positive association between low social capital/low social participation and daily smoking is well known. However, both social participation and daily smoking are associated with psychosocial work conditions and unemployment. Psychosocial work conditions and unemployment may affect daily smoking both directly and through a pathway including social participation.
Aleksandr V. Polukarov
Full Text Available Objective to show the capabilities of administrativelegal regulation for combating the causes and conditions determining corrupt behavior in the social sphere. Methods dialectic approach to cognition of social phenomena enabling to analyze them in historical development and functioning in the context of the totality of objective and subjective factors that determined the choice of the following research methods analysis synthesis comparison systematic formallegal comparativelegal methods. Results the reasons and conditions determining the corruption in the social sphere were disclosed this leads to the conclusion that corruption counteraction should be based on 1 recognition of the social sphere as the key object of protection against corruption 2 elaboration of special administrativelegal means of corruption counteraction in the social sphere. It is necessary to take into account the features of social relations in such sectors as education healthcare culture physical culture and sports etc. A number of foreign countries took the path of developing legislation on corruption counteraction taking into account the specifics of various social sphere segments functioning. This experience is quite interesting from the viewpoint of developing means of combating the causes and conditions that determine corruption in the social sphere. A number of the Russian Federation subjects also elaborate regional programs of combating corruption in education healthcare and culture. In our opinion this experience should be transferred to the federal level of legal regulation. This will help to create a fullfledged system of corruption counteraction in the social sphere taking into account different levels of its functioning. Scientific novelty for the first time in administrativelegal science the ldquolaw of torts aspect of corruption in the social sphererdquo issue is considered the work reveals the causes and conditions that determine corruption in the social
Pfeiffer, Hans C.; Dhaliwal, Rajinder S.; Golladay, Steven D.; Doran, Samuel K.; Gordon, Michael S.; Kendall, Rodney A.; Lieberman, Jon E.; Pinckney, David J.; Quickle, Robert J.; Robinson, Christopher F.; Rockrohr, James D.; Stickel, Werner; Tressler, Eileen V.
The IBM/Nikon alliance is continuing pursuit of an EPL stepper alpha tool based on the PREVAIL technology. This paper provides a status report of the alliance activity with particular focus on the Electron Optical Subsystem developed at IBM. We have previously reported on design features of the PREVAIL alpha system. The new state-of-the-art e-beam lithography concepts have since been reduced to practice and turned into functional building blocks of a production level lithography tool. The electron optical alpha tool subsystem has been designed, build, assembled and tested at IBM's Semiconductor Research and Development Center (SRDC) in East Fishkill, New York. After demonstrating subsystem functionality, the electron optical column and all associated control electronics hardware and software have been shipped during January 2001 to Nikon's facility in Kumagaya, Japan, for integration into the Nikon commercial e-beam stepper alpha tool. Early pre-shipment results obtained with this electron optical subsystem are presented.
Full Text Available In human beings, experiments investigating fear conditioning with social stimuli are rare. The current study aims at translating an animal model for social fear conditioning (SFC to a human sample using an operant SFC paradigm in virtual reality (VR. Forty participants actively (using a joystick approached virtual male agents that served as conditioned stimuli (CS. During the acquisition phase, unconditioned stimuli (US, a combination of an air blast (5 bar, 10 ms and a female scream (95 dB, 40 ms, were presented when participants reached a defined proximity to the agent with a contingency of 75% for CS+ agents and never for CS- agents. During the extinction and the test phases, no US was delivered. Outcome variables were pleasantness ratings and physiological reactions in heart rate and fear-potentiated startle. Additionally, the influence of social anxiety, which was measured with the Social Phobia Inventory scale, was evaluated. As expected after the acquisition phase the CS+ was rated clearly less pleasant than the CS-. This difference vanished during extinction. Furthermore, the HR remained high for the CS+, while the HR for the CS- was clearly lower after than before the acquisition. Furthermore, a clear difference between CS+ and CS- after the acquisition indicated successful conditioning on this translational measure. Contrariwise extinction was not observed on the physiological variables. Importantly, at the generalization test, higher socially fearful participants rated pleasantness of all agents as low whereas the lower socially fearful participants rated pleasantness as low only for the CS+. SFC was successfully induced and extinguished confirming operant conditioning in this SFC paradigm. These findings suggest that the paradigm is suitable to expand the knowledge about the learning and unlearning of social fears. Further studies should investigate the operant mechanisms of development and treatment of social anxiety disorder.
Shiban, Youssef; Reichenberger, Jonas; Neumann, Inga D; Mühlberger, Andreas
In human beings, experiments investigating fear conditioning with social stimuli are rare. The current study aims at translating an animal model for social fear conditioning (SFC) to a human sample using an operant SFC paradigm in virtual reality. Forty participants actively (using a joystick) approached virtual male agents that served as conditioned stimuli (CS). During the acquisition phase, unconditioned stimuli (US), a combination of an air blast (5 bar, 10 ms) and a female scream (95 dB, 40 ms), were presented when participants reached a defined proximity to the agent with a contingency of 75% for CS+ agents and never for CS- agents. During the extinction and the test phases, no US was delivered. Outcome variables were pleasantness ratings and physiological reactions in heart rate (HR) and fear-potentiated startle. Additionally, the influence of social anxiety, which was measured with the Social Phobia Inventory scale, was evaluated. As expected after the acquisition phase the CS+ was rated clearly less pleasant than the CS-. This difference vanished during extinction. Furthermore, the HR remained high for the CS+, while the HR for the CS- was clearly lower after than before the acquisition. Furthermore, a clear difference between CS+ and CS- after the acquisition indicated successful conditioning on this translational measure. Contrariwise no CS+/CS- differences were observed in the physiological variables during extinction. Importantly, at the generalization test, higher socially fearful participants rated pleasantness of all agents as low whereas the lower socially fearful participants rated pleasantness as low only for the CS+. SFC was successfully induced and extinguished confirming operant conditioning in this SFC paradigm. These findings suggest that the paradigm is suitable to expand the knowledge about the learning and unlearning of social fears. Further studies should investigate the operant mechanisms of development and treatment of social anxiety
Full Text Available This paper analyzes the natural and social conditions for the development economy in northeastern Montenegro, in the example municipalities Berane, Andrejevica and Plav in the geographical context of its utilization and use. Spatial distribution of the economy is determined by the natural and social conditions. The natural conditions in terms of the economy are of particular significance relief, climatic and hydrographic conditions, soil... According to degree benefits of natural conditions extracted are three relatively homogeneous regions. That is, which rational production of this part of north-eastern Montenegro, can be organized taking into account the natural conditions and the level of socio-economic development. For collocation and the structure of the economy have an important role in the social conditions which the economy is formed. Our research the records clearly pointed to the forefront some very obvious problems: first, is related to the population, especially in workforce, respectively, for the aging; second, that there is a strong migration of people whose intensive processes of differentiation and left behind an unfavorable structure of the population - age and education what the any negative impact on economic development; third, the characteristics of land area, its small size, inadequate and outdated processing, low technical capacity. The natural resources of this part of north-eastern Montenegro, as well as the population as a factor of economic development need to have met: economic, social, developmental organizational and management dimension to be on benefit the present, but also future generations
Lacy, Ryan T; Strickland, Justin C; Smith, Mark A
Traditionally, the analysis of intravenous drug self-administration is limited to conditions in which subjects are tested in isolation. This limits the translational appeal of these studies because drug use in humans often occurs in the presence of others. We used custom-built operant conditioning chambers that allowed social dyads visual, olfactory, auditory, and limited tactile contact while concurrently self-administering cocaine. Male rats were trained to respond according to a fixed interval schedule of reinforcement (with a limited hold) in order to determine if patterns of cocaine (0.75mg/kg/infusion) self-administration became more similar over time in social pairs. Cocaine self-administration was tested across five days according to a 10-min fixed interval schedule (with a 5-min limited hold). Quarter-life values (time at which 25% of responses were emitted per interval) were analyzed using intraclass correlations. The total number of reinforcers obtained did not vary across the five days of testing; however, quarter-life values became progressively more similar between individuals within the social dyads. Standard operant conditioning chambers are unable to assess responding in multiple animals due to their small size, the need to prevent subjects from responding on the lever of their partner, and the need to prevent infusion lines from entangling. By using custom-built social operant conditioning chambers, we assessed the effects of social contact on cocaine self-administration. Social operant conditioning chambers can be used as a preclinical method to examine social influences on drug self-administration under conditions that approximate human substance use. Copyright © 2014 Elsevier B.V. All rights reserved.
Gowen, Kris; Deschaine, Matthew; Gruttadara, Darcy; Markey, Dana
This study examined ways that young adults with mental illnesses (1) currently use social networking; and (2) how they would like to use a social networking site tailored for them. The authors examined differences between those with mental health conditions and those without. An online survey was administered by the National Alliance on Mental Illness (NAMI) to 274 participants; of those, 207 reported being between 18 and 24 years old. The survey included questions about current social networking use, the key resources respondents believed young adults living with mental illness need, and the essential components that should be included in a social networking site specifically tailored to young adults living with mental illness. Pearson Chi-square analyses examined the differences between those who reported having a mental illness and those who did not. Results indicate that almost all (94%) participants with mental illnesses currently use social networking sites. Individuals living with a mental illness are more likely than those not living with a mental illness to report engaging in various social networking activities that promote connectivity and making online friends. Individuals living with mental illnesses are also more likely to report wanting resources on independent living skills and overcoming social isolation available on a social networking site. Young adults living with mental illnesses are currently using social networking sites and express high interest in a social networking site specifically tailored to their population with specific tools designed to decrease social isolation and help them live more independently. These results indicate that practitioners should themselves be aware of the different social networking sites frequented by their young adult clients, ask clients about their use of social networking, and encourage safe and responsible online behaviors.
Oliva López Arellano
Full Text Available In the last 30 years, Mexico has faced major crises in its political, economic, and social life. These crises have affected living conditions and health. With the implementation in the 1980's of structural adjustment and economic stabilization policies, Mexico saw a rapid growth of poverty accelerating trends toward social polarization and social division. The current crisis, fueled by deregulation of the global financial markets, only deepens the tendency towards economic stagnation. It has led to an increase in unemployment, worsening income inequalities, and generalized inflation. The increase in food prices, in particular, has made life more difficult for the Mexican population. The crisis has had a palpable and concrete impact on living conditions, health status, and food security for diverse social groups.
Charlotte O. Brand
Full Text Available Social learning provides an effective route to gaining up-to-date information, particularly when information is costly to obtain asocially. Theoretical work predicts that the willingness to switch between using asocial and social sources of information will vary between individuals according to their risk tolerance. We tested the prediction that, where there are sex differences in risk tolerance, altering the variance of the payoffs of using asocial and social information differentially influences the probability of social information use by sex. In a computer-based task that involved building a virtual spaceship, men and women (N = 88 were given the option of using either asocial or social sources of information to improve their performance. When the asocial option was risky (i.e., the participant’s score could markedly increase or decrease and the social option was safe (i.e., their score could slightly increase or remain the same, women, but not men, were more likely to use the social option than the asocial option. In all other conditions, both women and men preferentially used the asocial option to a similar degree. We therefore found both a sex difference in risk aversion and a sex difference in the preference for social information when relying on asocial information was risky, consistent with the hypothesis that levels of risk-aversion influence the use of social information.
Aura González Serna
Full Text Available This article aims to instill reflections on the theoretical debate around the development. The premise for fixing the analysis is to consider the impact of modes of apprehending social existence, since it is demarcated between subjectivities and objective conditions. Different conceptions appear to interpret and represent the individual and collective imagination. Fragmentation between subjectivity and objectivity, constitute an impediment to understanding the generic nature of being that builds and permanently transformed the social existence.
Kornreich, C; Delle-Vigne, D; Knittel, J; Nerincx, A; Campanella, S; Noel, X; Hanak, C; Verbanck, P; Ermer, E
Aims To study the “social brain” in alcoholics by investigating social contract reasoning, theory of mind, and emotional intelligence. Design A behavioral study comparing recently detoxified alcoholics with normal, healthy controls. Setting Emotional intelligence and decoding of emotional non-verbal cues have been shown to be impaired in alcoholics. This study explores whether these deficits extend to conditional reasoning about social contracts. Participants 25 recently detoxified alcoholics (17 men and 8 women) were compared with 25 normal controls (17 men and 8 women) matched for sex, age, and education level. Measurements Wason Selection Task investigating conditional reasoning on three different rule types (social contract, precautionary, and descriptive), Revised Reading the Mind in the Eyes Test, Trait Emotional Intelligence Questionnaire (modified version), and additional control measures. Findings Conditional reasoning was impaired in alcoholics. Performance on descriptive rules was not above chance. Reasoning performance was markedly better on social contract and precautionary rules, but this performance was still significantly lower than in controls. Several emotional intelligence measures were lower in alcoholics compared to controls, but these were not correlated with reasoning performance. Conclusions Conditional reasoning and emotional intelligence appear impaired in alcoholics. Impairment was particularly severe on descriptive rules. Though alcoholics' performance was better on social contract and precautionary rules, overall reasoning performance was still low. Differential performance is consistent with distinct neurocognitive reasoning mechanisms and partial resilience of evolutionarily-relevant functions. Impairment in social contract reasoning might lead to misunderstandings and frustration in social interactions, and reasoning difficulties about precautionary rules might contribute to risky behaviors in this population. PMID:21205056
Kummer, Kai; Klement, Sabine; Eggart, Vincent; Mayr, Michael J; Saria, Alois; Zernig, Gerald
A main challenge in the therapy of drug dependent individuals is to help them reactivate interest in non-drug-associated activities. We previously developed a rat experimental model based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of social interaction with a gender- and weight-matched male Sprague Dawley rat (1) reversed CPP from cocaine to social interaction despite continuing cocaine training and (2) prevented the reinstatement of cocaine CPP. In the present study, we investigated which of the sensory modalities of the composite stimulus "social interaction" contributes most to the rats' preference for it. If touch was limited by steel bars spaced at a distance of 2 cm and running across the whole length of a partitioning, CPP was still acquired, albeit to a lesser degree. If both rats were placed on the same side of a partitioning, rats did not develop CPP for social interaction. Thus, decreasing the available area for social interaction from 750 to 375 cm(2) prevented the acquisition of CPP to social interaction despite the fact that animals could touch each other more intensely than through the bars of the partitioning. When touch was fully restricted by a glass screen dividing the conditioning chambers, and the only sensory modalities left were visual and olfactory cues, place preference shifted to place aversion. Overall, our findings indicate that the major rewarding sensory component of the composite stimulus "social interaction" is touch (taction).
Sierra, Leonardo A.; Yepes, Víctor; Pellicer, Eugenio
Assessing the viability of a public infrastructure includes economic, technical and environmental aspects; however, on many occasions, the social aspects are not always adequately considered. This article proposes a procedure to estimate the social sustainability of infrastructure projects under conditions of uncertainty, based on a multicriteria deterministic method. The variability of the method inputs is contributed by the decision-makers. Uncertain inputs are treated through uniform and beta PERT distributions. The Monte Carlo method is used to propagate uncertainty in the method. A case study of a road infrastructure improvement in El Salvador is used to illustrate this treatment. The main results determine the variability of the short and long-term social improvement indices by infrastructure and the probability of the position in the prioritization of the alternatives. The proposed mechanism improves the reliability of the decision making early in infrastructure projects, taking their social contribution into account. The results can complement environmental and economic sustainability assessments. - Highlights: •Estimate the social sustainability of infrastructure projects under conditions of uncertainty •The method uses multicriteria and Monte Carlo techniques and beta PERT distributions •Determines variability of the short and long term social improvement •Determines probability in the prioritization of alternatives •Improves reliability of decision making considering the social contribution
Frier, Amanda; Barnett, Fiona; Devine, Sue
This systematic literature review aims to explore the relationship between social determinants of health (SDH), and the rehabilitation of neurological conditions. In particular, the review will consider relationships between social determinants and peoples' attendance and sustained adherence to rehabilitation programs, and motivation regarding neurological rehabilitation. A systematic search of peer-reviewed literature from electronic databases; MEDLINE, Scopus, CINAHL and Informit health, was conducted. Papers published between 2004 and 2014 were considered. Eleven quantitative studies met the inclusion criteria. There was a lack of research addressing SDH and neurological rehabilitation simultaneously. Cardiac and cancer rehabilitation studies reported employment and income, social support, transport, housing and food security as the most frequent SDH factors influencing attendance, sustained adherence and motivation. Given this association, a similar relationship between neurological rehabilitation and SDH is plausible. Rehabilitation of neurological conditions can be a long and difficult process. To pursue optimal outcomes, an individual's social circumstances should be considered. Understanding how SDH interact with neurological rehabilitation may enhance service delivery, thus maximizing the possible rehabilitation outcomes for individuals. Future research that considers SDH and rehabilitation of neurological conditions jointly may benefit service providers and those requiring neurological rehabilitation. Implications for Rehabilitation Social determinants of health are important to consider in the rehabilitation of neurological conditions. Understanding the interplay between the social determinants of health and neurological rehabilitation may enhance the possible outcomes for those requiring rehabilitation. Increased awareness and capacity of health care professionals involved in neurological rehabilitation may hasten momentum towards decreased health
Tatiana V. Furyaeva,
Full Text Available The relevance of the study is due to the need to overcome social exclusion of adolescents and young people caused by their health condition and restrictions on life in the context of inclusion trends in the worldwide social policy and practice. In this connection, the article aims to justify and search for hospital-substitute format of social and pedagogical support for young people with psychophysical behavior disorders of an autism spectrum disorder (ASD type. The leading approach in the research of this issue is an integrative activity-based approach that allows comprehensive consideration of socio-political, organizational-pedagogical and technological opportunities for active inclusion of families with children and adolescents with ASD into joint activities in a social settlement. In the article, results of sociological, and psychological-pedagogical studies of the issue of social inclusion of individuals at risks of their exclusion from society are presented; various types of social integration practices are typologically disclosed; the author’s structural-functional model of a supported living arrangement is substantiated; conditions and possibilities for its implementation by a public organization of parents having children with autism in the regional context as exemplified by a rural settlement are identified and shown. The information presented in the article is of practical value for specialists in social pedagogy and work, as well as for those who are trained for concrete competences of social support of families having children with disabilities. The results of the given socio-pedagogical project may be useful for the development of the social movement of parents.
This article, by problematising the relationship between technology, art and the socialconditions, aims to examine the ways through which new artistic positions are emergingwithin digital capitalist conditions. The postfordist society of control works with digitaltechnologies and this has produced mechanisms of bio-power which are articulatedaround the code. Under the conditions of digital culture in which social relations areorganised around the network structure, an examination of the manif...
Fischer, D.J.; Epstein, J.B.; Yao, Y.; Wilkie, D.J.
Purpose Oral conditions are established complications in terminally-ill cancer patients. Yet despite significant morbidity, the characteristics and impact of oral conditions in these patients are poorly documented. The study objective was to characterize oral conditions in terminally-ill cancer patients to determine the presence, severity, and the functional and social impact of these oral conditions. Methods This was an observational clinical study including terminally-ill cancer patients (2.5–3 week life expectancy). Data were obtained via the Oral Problems Scale (OPS) that measures the presence of subjective xerostomia, orofacial pain, taste change, and the functional/social impact of oral conditions and a demographic questionnaire. A standardized oral examination was used to assess objective salivary hypofunction, fungal infection, mucosal erythema, and ulceration. Regression analysis and t test investigated the associations between measures. Results Of 104 participants, most were ≥50 years of age, female, and high-school educated; 45% were African American, 43% Caucasian, and 37% married. Oral conditions frequencies were: salivary hypofunction (98%), mucosal erythema (50%), ulceration (20%), fungal infection (36%), and other oral problems (46%). Xerostomia, taste change, and orofacial pain all had significant functional impact; poral ulcerations had significantly more orofacial pain with a social impact than patients without ulcers (p=.003). Erythema was significantly associated with fungal infection and with mucosal ulceration (pOral conditions significantly affect functional and social activities in terminally-ill cancer patients. Identification and management of oral conditions in these patients should therefore be an important clinical consideration. PMID:24232310
Amendola, Fernanda; Alvarenga, Márcia Regina Martins; Latorre, Maria do Rosário Dias de Oliveira; Oliveira, Maria Amélia de Campos
The Family Vulnerability Index to Disability and Dependence (FVI-DD) aims to summarize the dimensions of vulnerability to disability and dependence using family data monitored by Family Health Strategy (ESF) teams. This study aims to analyze the FVI-DD according to the social and health vulnerability, to validate and extract a cutoff point for each dimension. The FVI-DD was built with a sample of 248 families living in a region of São Paulo. The dimension related to health conditions was validated with good internal consistency, with respect to the Katz Index and the Lawton Scale, whereas the dimension related to social conditions was only validated in relation to Lawton Scale. Thus, a vulnerable family was defined as one with 15 or more points in the Total FVI-DD, and a vulnerable family in health conditions that with a score of 6 or more points in that dimension. Therefore, it is possible to classify families as not vulnerable, vulnerable in the social aspects, vulnerable in the health aspects and the more vulnerable family (social and health) using social indicators of empowerment and wear and health indicators related not only to the biological sphere, but also in the access to health services, health self-assessment and existing vulnerable groups.
N. V. Burmaha
Full Text Available This article deals with the approach to interpretation of essence of the network community concept in which we propose to consider it as a new form of social organization that is substantiated by the specificity of how our society is functioning in conditions of Postmodern. There were explored two main approaches to network communities studying: the first approach considers social networks in a classic, traditional interpretation of modernity as a special kind of social structure, and the second one represents social networks as a specific virtual formation, a social structure of virtual Internet reality. There were revealed some common features of a social organization and a network community: presence of permanent communication between members of the group, united by certain common interests and goals, as well as presence of the certain hierarchy among all members of the community, and the rules of conduct, implementation of communication. Distinctive features: network community is more informal, offers its members considerable leeway in the implementation of their own goals and satisfying the needs, full virtualization of communication absence of direct interaction during communication, under conditions where the main resource for the interchange in network communities is information. It was shown that in the process of emergence, development and distribution of network communities, the fundamental role is played by modern communications - namely, unification them in a stable set of interconnected networks and, in particular network communities.
Farr, William; Yuill, Nicola; Raffle, Hayes
Tangible user interfaces (TUIs) embed computer technology in graspable objects. This study assessed the potential of Topobo, a construction toy with programmable movement, to support social interaction in children with Autistic Spectrum Conditions (ASC). Groups of either typically developing (TD) children or those with ASC had group play sessions…
Larry Blocker; Susan K. Hagle; Rick Lasko; Robert Keane; Barry Bollenbacher; Bruce Fox; Fred Samson; Randy Gay; Cynthia Manning
Relationships between the development of desired conditions based on todayâs social values, and an understanding of the historic range of variability (HRV) are key to the implementation of ecosystem management. Relevant to the discussion are wildlife habitat values, forage production, economics related to wood resources, aesthetics and visual quality, changes in...
... years (mean age = 14.53). Results indicated that performance was significantly poorer in the group condition than in the alone condition (p. <05); and reward significantly attenuated social loafing effect in the group condition (p. <05). These observations were discussed in relation to the prevailing challenge in team work.
Ransom, J.I.; Cade, B.S.; Hobbs, N.T.
Managers concerned with shrinking habitats and limited resources for wildlife seek effective tools for limiting population growth in some species. Fertility control is one such tool, yet little is known about its impacts on the behavioral ecology of wild, free-roaming animals. We investigated influences of the immunocontraceptive porcine zona pellucida (PZP) on individual and social behavior in bands of feral horses (Equus caballus) in three discrete populations and used 14 hierarchical mixed effect models to gain insight into the influences of PZP treatment on feral horse behavior. A model of body condition was the strongest predictor of feeding, resting, maintenance, and social behaviors, with treated females allocating their time similarly to control females. Time spent feeding declined 11.4% from low condition to high condition females (F1,154 = 26.427, P modifications in feral horses.
Jones, Carolyn E; Riha, Penny D; Gore, Andrea C; Monfils, Marie-H
Pairing a previously neutral conditioned stimulus (CS; e.g., a tone) to an aversive unconditioned stimulus (US; e.g., a foot-shock) leads to associative learning such that the tone alone will elicit a conditioned response (e.g., freezing). Individuals can also acquire fear from a social context, such as through observing the fear expression of a conspecific. In the current study, we examined the influence of kinship/familiarity on social transmission of fear in female rats. Rats were housed in triads with either sisters or non-related females. One rat from each cage was fear conditioned to a tone CS+ shock US. On day two, the conditioned rat was returned to the chamber accompanied by one of her cage mates. Both rats were allowed to behave freely, while the tone was played in the absence of the foot-shock. The previously untrained rat is referred to as the fear-conditioned by-proxy (FCbP) animal, as she would freeze based on observations of her cage-mate's response rather than due to direct personal experience with the foot-shock. The third rat served as a cage-mate control. The third day, long-term memory tests to the CS were performed. Consistent with our previous application of this paradigm in male rats (Bruchey et al. in Behav Brain Res 214(1):80-84, 2010), our results revealed that social interactions between the fear conditioned and FCbP rats on day two contribute to freezing displayed by the FCbP rats on day three. In this experiment, prosocial behavior occurring at the termination of the cue on day two was significantly greater between sisters than their non-sister counterparts, and this behavior resulted in increased freezing on day three. Our results suggest that familiarity and/or kinship influences the social transmission of fear in female rats.
Full Text Available Background: Modern societies spend most of their time indoors, namely at home, and the indoor environment quality turns out to be a crucial factor to health, quality of life and well-being of the residents. The present study aims to understand how indoor environment relates with quality of life and how improving housing conditions impacts on individuals’ health. Design and Methods: This study case will rely on the following assessments in both rehabilitated and non-rehabilitated social housing: i field measurements, in social dwellings (namely temperature, relative humidity, carbon dioxide concentration, air velocity, air change rate, level of mould spores and energy consumption; ii residents’ questionnaires on social, demogaphic, behavioural, health characteristics and quality of life. Also, iii qualitative interviews performed with social housing residents from the rehabilitated houses, addressing the self-perception of living conditions and their influence in health status and quality of life. All the collected information will be combined and analysed in order to achieve the main objective. Expected impact: It is expected to define a Predicted Human Life Quality (PHLQ index, that combines physical parameters describing the indoor environment measured through engineering techniques with residents’ and neighbourhood quality of life characteristics assessed by health questionnaires. Improvement in social housing should be related with better health indicators and the new index might be an important tool contributing to enhance quality of life of the residents.
Arun Ranga Swamy
Full Text Available Since poverty is often believed to be a root cause of clientelism, government policies to reduce poverty should also help to reduce clientelism. However, scholars studying clientelism are more likely to view social policy as a potential resource for clientelist politicians. This article examines this paradox in the Philippine context by offering a general framework to identify when social welfare policies are likely to reduce clientelism, and by applying this framework to the Philippines, focusing on the Pantawid Pamilyang Pilipino conditional cash transfer programme, or Pantawid. I argue that the policies that are most likely to undercut clientelism are universal social protection policies that provide poor families with security, although these are the least acceptable to middle-class taxpayers. This is exemplified by the Philippines, which has tended to introduce social policies that increase the scope for clientelism by making discretionary allocation more likely, rather than policies that offer income security to the poor. The Pantawid programme attempts to overcome these problems by introducing a centralised targeting mechanism to identify beneficiaries and by guaranteeing the benefit to all eligible families, but like all conditional cash transfer programs falls short of guaranteed and universal social protection.
Soares, Sara; Fraga, Silvia; Delgado, Joao M P Q; Ramos, Nuno M M
Modern societies spend most of their time indoors, namely at home, and the indoor environment quality turns out to be a crucial factor to health, quality of life and well-being of the residents. The present study aims to understand how indoor environment relates with quality of life and how improving housing conditions impacts on individuals' health. This study case will rely on the following assessments in both rehabilitated and non-rehabilitated social housing: i) field measurements, in social dwellings (namely temperature, relative humidity, carbon dioxide concentration, air velocity, air change rate, level of mould spores and energy consumption); ii) residents' questionnaires on social, demogaphic, behavioural, health characteristics and quality of life. Also, iii) qualitative interviews performed with social housing residents from the rehabilitated houses, addressing the self-perception of living conditions and their influence in health status and quality of life. All the collected information will be combined and analysed in order to achieve the main objective. It is expected to define a Predicted Human Life Quality (PHLQ) index, that combines physical parameters describing the indoor environment measured through engineering techniques with residents' and neighbourhood quality of life characteristics assessed by health questionnaires. Improvement in social housing should be related with better health indicators and the new index might be an important tool contributing to enhance quality of life of the residents. Significance for public healthThis study will contribute to understand how indoor environment relates with quality of life and how improving housing conditions impacts on individuals' health, in social housing neighbourhoods. As so, it is important to share the undertaken methodology carried out by a multidisciplinary team, in order to allow other researchers following comparable studies to adopt a similar approach. The case study results will allow
Full Text Available Purpose - A conducive and enabling environment is imperative for the formation of sustainable social business enterprises (SBEs. This paper aims to identify the macro-level enabling conditions necessary for SBE formation and to analyze them in the context of the Philippines, an emerging economy that is yet to be transformed into an inclusive one. Design/methodology/approach - Major developments on micro-, small- and medium-sized enterprises, specifically on social enterprises, were revisited and analyzed. The author also looked into how they are sustained, supported and nurtured in the Philippines’ overall economic landscape. Extensive data were collected from relevant agencies in public and private sectors, after which they were analyzed parallel to existing academic literature, i.e. theories, models and concepts, on social entrepreneurship and development nexus. Findings - It has been found that the four macro-level enabling conditions, namely, governance, socially inclusive economic approach, financial services and entrepreneurial culture, presumed to be vital for SBE formation, contribute to the latter at various levels, but surely complement each other in the process. Research limitations/implications - The significance of exploring the context in which social enterprises are formed and flourish lies in the sheer importance of understanding the sustained prevalence of SBEs in many economies – both in developed and developing ones. Originality/value - By having a more structured knowledge of the components surrounding SBE formation, the community may be able to also simultaneously explore why and how social entrepreneurs form profit-earning business entities that are primarily driven by social advocacies and goals.
This paper aims to explain through a qualitative case study how a small protest group prevailed during a local windfarm conflict in south-eastern Australia. A social capital analytical framework was developed to analyse the data. The analysis found that two communities inhabited the area for which the windfarm development was proposed. The public participation process failed to address the concerns of both communities and led to the emergence of a social network of resistance. The network had high stocks of bridging social capital, which enabled an effective protest that led to the abandonment of the development. Their effectiveness was inadvertently aided by the windfarm supporters who were unable to act collectively to defend their interests because socio-economic changes in the community among other factors had led to a depletion of their social capital. In this context, different democratic participatory processes were needed to address the concerns of the two communities. Guidance and tools for researching and developing the types of participatory processes needed for vulnerable communities with low social capital and those similar to the social network with high social capital are provided. These will inform community-appropriate public participation processes and participatory planning policy. - Highlights: ► A case study of a local social network's resistance to a windfarm is undertaken. ► The link between high social capital and resistance is confirmed. ► Successful protest groups can be aided by passive windfarm supporters. ► Protesters are likely to participate in well-designed participatory processes. ► Guidance for developing community-specific participatory processes is provided
Full Text Available Abstract Background Low and middle income countries are ageing at a much faster rate than richer countries, especially in Asia. This is happening at a time of globalisation, migration, urbanisation, and smaller families. Older people make significant contributions to their families and communities, but this is often undermined by chronic disease and preventable disability. Social participation can help to protect against morbidity and mortality. We argue that social participation deserves much greater attention as a protective factor, and that older people can play a useful role in the prevention and management of chronic conditions. We present, as an example, a low-cost, sustainable strategy that has increased social participation among elders in Sri Lanka. Discussion Current international policy initiatives to address the increasing prevalence of non-communicable chronic diseases are focused on cardiovascular disease, diabetes, respiratory disease and cancers, responsible for much premature mortality. Interventions to modify their shared risk factors of high salt and fat diets, inactivity, smoking and alcohol use are advocated. But older people also suffer chronic conditions that primarily affect quality of life, and have a wider range of risk factors. There is strong epidemiological and physiological evidence that social isolation, in particular, is as important a risk factor for chronic diseases as the 'lifestyle' risk factors, yet it is currently neglected. There are useful experiences of inexpensive and sustainable strategies to improve social participation among older people in low and lower middle income countries. Our experience with forming Elders' Clubs with retired tea estate workers in Sri Lanka suggests many benefits, including social support and participation, inter-generational contact, a collective voice, and facilitated access to health promotion activities, and to health care and social welfare services. Summary Policies to
Almeida, Carla; Massarani, Luisa
Genetically modified organisms have been at the centre of a major public controversy, involving different interests and actors. While much attention has been devoted to consumer views on genetically modified food, there have been few attempts to understand the perceptions of genetically modified technology among farmers. By investigating perceptions of genetically modified organisms among Brazilian farmers, we intend to contribute towards filling this gap and thereby add the views of this stakeholder group to the genetically modified debate. A comparative analysis of our data and data from other studies indicate there is a complex variety of views on genetically modified organisms among farmers. Despite this diversity, we found variations in such views occur within limited parameters, concerned principally with expectations or concrete experiences regarding the advantages of genetically modified crops, perceptions of risks associated with them, and ethical questions they raise. We then propose a classification of prevailing profiles to represent the spectrum of perceptions of genetically modified organisms among farmers.
Huster, E U
Good health is not distributed equally, neither in life conditions--including the individual ability to act--nor according to the supply grid. These interrelations, shown in several empirical investigations, assume more importance in view of the groving tendency to social polarisation in the countries of Europe, different in fact in the single countries, but clear in respect of tendency: social exclusion does not only mean to have less financial resources but also social disadvantages in other realms of living, especially in health. Migration, not only from East to West, but also inside and between the countries of the European Union and inside of Eastern Europe too, is only an especially dear expression that social problems have their origin in international problems and casualities, but become visible in local and regional structures and thus in the responsibility of the municipalities. Globalisation, Europe etc., terms mostly connected with positive connotations, have not only a positive side, but also another one, namely, the re-regionalisation of social problems especially in the municipalities. Normally the municipalities have to counterbalance and to regulate the negative consequences of these European--and moreover international--changes of the structures, although their financial means are declining. The municipal health service is integrated in this contradictory constellation. To prevent irrational social and/or political developments, the reasons and possible strategies of reform policy will have to be discussed carefully.
Gülcan, Ferda; Ekbäck, Gunnar; Ordell, Sven; Lie, Stein Atle; Åstrøm, Anne Nordrehaug
A life course perspective recognizes influences of socially patterned exposures on oral health across the life span. This study assessed the influence of early and later life social conditions on tooth loss and oral impacts on daily performances (OIDP) of people aged 65 and 70 years. Whether social inequalities in oral health changed after the usual age of retirement was also examined. In accordance with "the latent effect life course model", it was hypothesized that adverse early-life social conditions increase the risk of subsequent tooth loss and impaired OIDP, independent of later-life social conditions. Data were obtained from two cohorts studies conducted in Sweden and Norway. The 2007 and 2012 waves of the surveys were used for the present study. Early-life social conditions were measured in terms of gender, education and country of birth, and later-life social conditions were assessed by working status, marital status and size of social network. Logistic regression and Generalized Estimating Equations (GEE) were used to analyse the data. Inverse probability weighting (IPW) was used to adjust estimates for missing responses and loss to follow-up. Early-life social conditions contributed to tooth loss and OIDP in each survey year and both countries independent of later-life social conditions. Lower education correlated positively with tooth loss, but did not influence OIDP. Foreign country of birth correlated positively with oral impacts in Sweden only. Later-life social conditions were the strongest predictors of tooth loss and OIDP across survey years and countries. GEE revealed significant interactions between social network and survey year, and between marital status and survey year on tooth loss. The results confirmed the latent effect life course model in that early and later life social conditions had independent effects on tooth loss and OIDP among the elderly in Norway and Sweden. Between age 65 and 70, inequalities in tooth loss related to marital
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Zakharova, E; Miller, J; Unterwald, E; Wade, D; Izenwasser, S
This study was done to determine whether social and environmental factors alter cocaine reward and proteins implicated in mediating drug reward in rats during early adolescence. On postnatal day (PND) 23, rats were housed under conditions where both social (number of rats per cage) and environmental (availability of toys) factors were manipulated. Socially isolated rats were housed alone impoverished with no toys (II) or enriched with toys (IE). Social rats were housed two rats/cage with no toys (SI2) or with toys (SE2), or three/cage with (SE3) or without (SI3) toys. On PND 43, cocaine conditioned place preference (CPP) sessions began with the post-test done on PND 47. Cocaine CPP was established in response to 5 or 10 mg/kg cocaine in II rats, and CPP was decreased with the addition of cage mates or toys. No CPP was seen to any dose in SI3 or SE3 rats. Enriched housing (SE3) increased dopamine transporter (DAT) protein in the nucleus accumbens compared to II. There also were differential effects of cocaine on tyrosine hydroxylase and DAT depending on housing, with both increased by cocaine in II but not SE3 rats. DARPP-32 was unchanged by housing or cocaine, while phospho-Thr(34)-DARPP-32 was increased by cocaine treatment across conditions. Thus, both social and environmental enrichment decrease cocaine CPP during adolescence and different housing alters proteins that regulate dopaminergic neurotransmission in a manner that may account for the observed differences in cocaine-induced reward.
Alexia Delclaux Gaytán de Ayala
Full Text Available This paper analyses the role of conditional cash transfers (CCT in improving social indicators during the past decade in Brazil and Peru. Barely two decades after the appearance of the first programmes, CCTs – cash transfers to families living in poverty or extreme poverty conditioned to school attendance and compulsory medical visits for children – are now one of the main policy tools in the fight against poverty in dozens of developing countries. More specifically, this paper examines the link between the CCT programme in each of these two countries – the giant Bolsa Familia in Brazil, the pioneer and largest program of this type in the world, and Juntos in Peru, smaller in terms of size and relevance, but practically identical in its design – and the evolution of social indicators relative to poverty, education and health.
Full Text Available The aim of this article is to investigate the structural relationship between social influence, motivation and facilitating conditions with the use behaviour of teleworking technology, considering the moderating effect of behavioural intention to utilize teleworking. The research is done according to descriptive method with correlational type. Statistical population is public organizations and the sample was selected using simple random sampling. Data collection tool was questionnaire and experts judged its validity. The reliability of the tool was evaluated using a pre-test of 30 people. The data gathered from a sample of 365 people used to test the hypothesis and conceptual model of the research. By exploratory factor analysis and structural equation model path analysis was done. The results show that social influence, motivation and facilitating conditions have a positive impact on behavioural intention to use teleworking systems and this behavioural intention cause an increase in using behaviour among employees.
Melanie E. Cox
Full Text Available Previous research has shown that the presence of natural areas is beneficial to human well-being. However, to date there have been few published studies of the effects that the condition of natural areas have on well-being. We hypothesize that coastal waterways that are perceived to be in better condition are visited more often by local residents, and as a result, residents will develop a stronger sense of place and stronger social relations with other residents, which will in turn lead to a higher quality of life. A survey was conducted to test this hypothesis in two coastal regions in Queensland, Australia. A weak relationship was found between perceived coastal quality and the number of recreational visits. In both study areas, frequency of visits to coastal waterways was significantly related to quality of life through an increased sense of place and social contacts. In the Douglas region, sense of place and social capital were closely related, and social capital was also related to quality of life. In both study areas, residents were most likely to visit waterways that were located in close proximity to their residence, suggesting that management of all waterways is essential for human well-being, and that benefits to humans will result from rehabilitating degraded waterways.
Crespi, Bernard; Leach, Emma; Dinsdale, Natalie; Mokkonen, Mikael; Hurd, Peter
Complex human social cognition has evolved in concert with risks for psychiatric disorders. Recently, autism and psychotic-affective conditions (mainly schizophrenia, bipolar disorder, and depression) have been posited as psychological 'opposites' with regard to social-cognitive phenotypes. Imagination, considered as 'forming new ideas, mental images, or concepts', represents a central facet of human social evolution and cognition. Previous studies have documented reduced imagination in autism, and increased imagination in association with psychotic-affective conditions, yet these sets of findings have yet to be considered together, or evaluated in the context of the diametric model. We first review studies of the components, manifestations, and neural correlates of imagination in autism and psychotic-affective conditions. Next, we use data on dimensional autism in healthy populations to test the hypotheses that: (1) imagination represents the facet of autism that best accounts for its strongly male-biased sex ratio, and (2) higher genetic risk of schizophrenia is associated with higher imagination, in accordance with the predictions of the diametric model. The first hypothesis was supported by a systematic review and meta-analysis showing that Imagination exhibits the strongest male bias of all Autism Quotient (AQ) subscales, in non-clinical populations. The second hypothesis was supported, for males, by associations between schizophrenia genetic risk scores, derived from a set of single-nucleotide polymorphisms, and the AQ Imagination subscale. Considered together, these findings indicate that imagination, especially social imagination as embodied in the default mode human brain network, mediates risk and diametric dimensional phenotypes of autism and psychotic-affective conditions. Copyright © 2016 Elsevier B.V. All rights reserved.
Kosaki, Yutaka; Watanabe, Shigeru
Oxytocin (OT) has been implicated in a variety of mammalian reproductive and social behaviors, and the use of intranasal OT for clinical purposes is on the rise. However, basic actions of OT, including the rewarding or reinforcing properties of the drug, are currently not fully understood. In this study, the authors investigated whether intranasally administered OT has different reinforcing properties for social and nonsocial stimuli and whether such effects are variable between male and female subjects. Conditioned social preference (CSP) and conditioned place preference (CPP) paradigms were used to examine social and nonsocial reinforcing properties of OT. In CSP, the presence of a same-sex unfamiliar conspecific was repeatedly paired with intranasal OT, while a different conspecific was associated with saline. The reinforcing effect of OT was assessed in a postconditioning choice test under a drug-free condition. In CPP, the 2 conspecifics were replaced with nonsocial black and white compartments. The authors found that intranasal OT (12 μg) in females supported the formation of CSP (Experiment 1) but not CPP (Experiment 3). Neither CSP (Experiment 2) nor CPP (Experiment 4) was formed in males. Extended conditioning with higher dose OT (36 μg), however, abolished the initial CSP in females and produced an aversion to the OT-paired stimulus mouse. Experiment 5 indicated that it was the repeated administrations rather than the higher dose that produced the abolition of the original preference. Overall, the current results demonstrate for the first time a sex- and stimulus-dependent reinforcing property of intranasal OT in mice. (PsycINFO Database Record (c) 2016 APA, all rights reserved).
Full Text Available The article reveals the characteristic features of modern trends in the formation and implementation of corporate social responsibility in Russia in the current economic conditions, which is based on the fact that reasonable economic interests oriented business not only on maximizing profits, but also to improve their own macro - socio-economic, natural, political, through voluntary investment profits in the respective areas.
Full Text Available Negative social experiences during adolescence increase the risk of psychiatric disorders in adulthood. Using resident-intruder stress, the present study aimed to investigate the effects of adolescent social defeat on emotional and cognitive symptoms associated with psychiatric disorders during adulthood and the effects of the developmental stage and social condition on this process. In experiment 1, animals were exposed to social defeat or manipulation for 10 days during early adolescence (EA, PND 28-37, late adolescence (LA, PND 38-47, and adulthood (ADULT, PND 70-79 and then singly housed until the behavioral tests. Behaviors, including social avoidance of the defeat context and cortically mediated cognitive flexibility in an attentional set-shifting task (AST, were assessed during the week following stress or after 6 weeks during adulthood. We determined that social defeat induced significant and continuous social avoidance across age groups at both time points. The mice that experienced social defeat during adulthood exhibited short-term impairments in reversal learning on the AST that dissipated after 6 weeks. In contrast, social defeat during EA but not LA induced a delayed deficit in extra-dimensional set-shifting in adulthood but not during adolescence. In experiment 2, we further examined the effects of social condition (isolation or social housing after stress on the alterations induced by social defeat during EA in adult mice. The adult mice that had experienced stress during EA exhibited social avoidance similar to the avoidance identified in experiment 1 regardless of the isolation or social housing after the stress. However, social housing after the stress ameliorated the cognitive flexibility deficits induced by early adolescent social defeat in the adult mice, and the social condition had no effect on cognitive function. These findings suggest that the effects of social defeat on emotion and cognitive function are differentially
Full text of publication follows: this study explores the connection between the perception of different societal risk, health concerns and behavioral attitudes of people in condition of social security threat. Two small and two big industrial towns were chosen in order to observe the social and psychological price of the structural changes in the industry such as unemployment and its reflection on the households and the individuals' social attitudes. Key stakeholders were interviewed and questionnaire survey was carried out. The results showed high level of risk sensitivity and health concerns when people felt threatened by lack of social and economic security. The pollution was found to be important problem when it caused direct and obvious risk to human health and the environment. In the same time reverse environmental behavior like insensitiveness and neglectful attitude was observed in cases when the health consequences of the pollution were perceived to be unclear and with delayed effect. In situation of a great socio-economic threat noninvolvement helped the individuals to adapt. The research proved the influence of several risk characteristics on risk perception. It was found a connection between the risk perception and risk controllability, voluntariness of exposure and cost/benefits distribution. In the study areas respondents' judgments on these characteristics reflected directly their social status and material state. The study presented here is in progress - it i's supported by research grant from Open Society Foundation. (author)
Kiyokawa, Yasushi; Kodama, Yuka; Takeuchi, Yukari; Mori, Yuji
In social animals, housing with conspecific animals after a stressful event attenuates the subsequent adverse outcomes due to the event, and this has been called housing-type social buffering. We have previously found that housing-type social buffering attenuates the enhancement of hyperthermia and Fos expression in the paraventricular nucleus of the hypothalamus that occurs in response to an aversive conditioned stimulus in male rats. Here, we analyzed the role of physical interactions during social housing in the induction of housing-type social buffering. When a fear-conditioned subject was alone after the conditioning and then exposed to the conditioned stimulus, it showed behavioral, autonomic, and neural stress responses. However, social housing, during which physical interactions were prevented by wire mesh, attenuated these autonomic and neural stress responses, as has been seen in previous studies. These results suggested that physical interaction was not necessary for the induction of housing-type social buffering. With this social cohabitation model, we then found that social cohabitation increased Fos expression in the posterior complex of the anterior olfactory nucleus of the fear-conditioned subject. Social cohabitation also increased Fos expression in 11 brain regions, including the prefrontal cortex, the nucleus accumbens, the bed nucleus of the stria terminalis, and the medial, lateral, basal, and cortical amygdala. These results provide information about the neural mechanisms that induce housing-type social buffering. Copyright © 2013 Elsevier B.V. All rights reserved.
this article describes social maturity of the identity of seniors as a condition of successful adaptation to the modern sociocultural environment, marks out some criteria of definition of socially mature personality, gives definition to the concept «social competence of the personality».
Full Text Available Background/Aim. Few authors are involved in home rehabilitation of amputees or their reintegration into the community. It has been remarked that there is a discontinuity between the phases of the amputee rehabilitation in Serbia. The aim of the study was to establish pain characteristics and functional status of amputees two months after the amputation and to determine their social function and the conditions of their habitation. Methods. This prospective observation study involved 38 elderly amputees with unilateral lower limb amputations. The patients were tested at the hospital on discharge and at their homes two months after the amputation. Pain intensity and functional status were measured by a visual analogue scale (VAS and by Functional Independence Measure (FIM. The patients’ social function was assessed using the Social Dysfunction Rating Scale (SDRS and conditions of their habitation by the self-created Scale of Conditions of Habitation (SCH. In statistic analysis we used the Student t test, χ2 test and Analysis of variance (ANOVA. Results. The majority of patients (63% underwent below knee amputation caused by diabetes (89%. A significant number of patients (84%, χ2 = 17.78; p < 0.01 was not visited by a physiotherapist nor an occupational therapist during two months at home. In this period, the majority of the amputees (68% had phantom pain or residual limb pain (21%. Two months after amputation the pain intensity was significantly lower (VAS = 4.07±2.19; 2.34±1.41; p < 0.001, and the functional status significantly better than on discharge (FIM = 75.13±16.52; 87.87±16.48; p < 0.001. The amputees had the average level of social dysfunction (SDRS = 62.00±11.68 and conditions of habitation (SCH = 7.81±1.97. Conclusion. A total 38 elderly amputees with unilateral lower limb amputations achieved significant functional improvement and reduction of pain, in spite of their social dysfunction, the absence of socio-medical support
Omar Alejandro De León Palomo
Full Text Available The suicide has existed throughout history and has prevailed as a behavior that was contrary to the rules of the society in terms of preservation of life itself; the objective of this research was to make emphasis on the nature of antisocial behavior of this behavior and show its prevalence in the years 2006 to 2010 in Mexico and Tamaulipas, as well as from 1999 to 2008 in Reynosa, Tamaulipas. For which the data were obtained from the National Institute of Statistics and Geography to the country and the State and the books of the register of deaths by cause violent of the Regional Unit of Expert Services of the Attorney General of Justice, which has its headquarters in Reynosa; developed a theoretical framework on the impact of the conduct in society and the means to prevent it, The data obtained we revealed the continued presence of this conduct year-on-year, 23.554 cases appearing in Mexico and 819 in Tamaulipas in the period from 2006 to 2010; in Reynosa, Tamaulipas were presented 278 suicides in the period 1999 to 2008. The results show us a conduct stable in numbers, but without excessive overflows that prevails year-on-year, suicide, and the attempt of the same should be viewed as a social problem and not detract from the importance that it deserves a conduct of these dimensions, that is no more than a reflection of the situation in which are the means of social control toward the preservation of life itself.
Törmä, Johanna; Winblad, Ulrika; Cederholm, Tommy; Saletti, Anja
During recent years public awareness about malnutrition has increased and collective initiatives have been undertaken. Simultaneously, the number of older adults is increasing, and the elderly care has been placed under pressure. The aim was to assess the nutritional situation and one-year mortality among nursing home (NH) residents, and compare with historical data. Mini Nutritional Assessment-Short Form (MNA-SF), ADL Barthel Index (BI), Short Portable Mental Status Questionnaire (SPMSQ), EQ-5D, Charlson Comorbidity Index (CCI), and blood samples were collected from 172 NH residents (86.3 ± 8 years, 70% women). Mortality data was taken from NH records. Nutritional data from 166 NH residents (83.8 ± 8 years, 61% women) examined in 1996 was retrieved for historical comparison. The prevalence of malnutrition was 30%, as compared to 71% in the historical data set, corresponding to a present average body mass index of 23.7 ± 5.1 compared with 22.3 ± 4.2 kg/m(2) (p prevails and is associated with deteriorated cognition, function and increased mortality. A possible improvement in nutritional status in NH residents over time was observed. Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
van de Leemput, J; Hess, J L; Glatt, S J; Tsuang, M T
Schizophrenia's (SZ's) heritability and familial transmission have been known for several decades; however, despite the clear evidence for a genetic component, it has been very difficult to pinpoint specific causative genes. Even so genetic studies have taught us a lot, even in the pregenomic era, about the molecular underpinnings and disease-relevant pathways. Recurring themes emerged revealing the involvement of neurodevelopmental processes, glutamate regulation, and immune system differential activation in SZ etiology. The recent emergence of epigenetic studies aimed at shedding light on the biological mechanisms underlying SZ has provided another layer of information in the investigation of gene and environment interactions. However, this epigenetic insight also brings forth another layer of complexity to the (epi)genomic landscape such as interactions between genetic variants, epigenetic marks-including cross-talk between DNA methylation and histone modification processes-, gene expression regulation, and environmental influences. In this review, we seek to synthesize perspectives, including limitations and obstacles yet to overcome, from genetic and epigenetic literature on SZ through a qualitative review of risk factors and prevailing hypotheses. Encouraged by the findings of both genetic and epigenetic studies to date, as well as the continued development of new technologies to collect and interpret large-scale studies, we are left with a positive outlook for the future of elucidating the molecular genetic mechanisms underlying SZ and other complex neuropsychiatric disorders. Copyright © 2016 Elsevier Inc. All rights reserved.
Zhang, Cheng; Phang, Chee Wei; Zeng, Xiaohua; Wang, Ximeng; Xu, Yunjie; Huang, Yun; Contractor, Noshir
Using large-scale interaction data from a virtual world, we show that people’s propensity to socialize (forming new social connections) varies by hour of the day. We arrive at our results by longitudinally tracking people’s friend-adding activities in a virtual world. Specifically, we find that people are most likely to socialize during the evening, at approximately 8 p.m. and 12 a.m., and are least likely to do so in the morning, at approximately 8 a.m. Such patterns prevail on weekdays and weekends and are robust to variations in individual characteristics and geographical conditions. PMID:26353080
Zhang, Cheng; Phang, Chee Wei; Zeng, Xiaohua; Wang, Ximeng; Xu, Yunjie; Huang, Yun; Contractor, Noshir
Using large-scale interaction data from a virtual world, we show that people's propensity to socialize (forming new social connections) varies by hour of the day. We arrive at our results by longitudinally tracking people's friend-adding activities in a virtual world. Specifically, we find that people are most likely to socialize during the evening, at approximately 8 p.m. and 12 a.m., and are least likely to do so in the morning, at approximately 8 a.m. Such patterns prevail on weekdays and weekends and are robust to variations in individual characteristics and geographical conditions.
Hannah Arendt is widely regarded as a political theorist who sought to rescue politics from "society," and political theory from the social sciences. This conventional view has had the effect of distracting attention from many of Arendt's most important insights concerning the constitution of "society" and the significance of the social sciences. In this article, I argue that Hannah Arendt's distinctions between labor, work, and action, as these are discussed in "The Human Condition" and elsewhere, are best understood as a set of claims about the fundamental structures of human societies. Understanding Arendt in this way introduces interesting parallels between Arendt's work and both classical and contemporary sociology. From this I draw a number of conclusions concerning Arendt's conception of "society," and extend these insights into two contemporary debates within contemporary theoretical sociology: the need for a differentiated ontology of the social world, and the changing role that novel forms of knowledge play in contemporary society as major sources of social change and order.
S. H. Zdrahat
Full Text Available The arrangement of optimal conditions for the successful social integration of individuals with disabilities is one of the important social tasks. The relevance of the topic is also growing due to the fact that in recent times there is a tendency of increase of people with functional health limitations all over the world and, particularly, in Ukraine. The absence of the enabling environment for the satisfaction of untypical children’s special needs and the limitation of their socio-cultural mobility and life chances makes the issue of development, education, social integration and adaptation of children with special needs actual. Therefore, the society must be ready now to offer the special programs of integration and self-fulfillment through education to this category of children. The objective of the article is to develop the model of evaluation being a social technology which will conceptualize the evaluation of the inclusive education for the efficient management of its quality. The areas of the educational system’s improvement for the successful realization of the social technology of the inclusive education’s evaluation have been identified. The aspects of the grounds of the inclusive education, such as the grounds of educational, social and economic nature have been defined. The purposes of the successful realization of inclusion have been described. The sociological approaches to the study of the quality of education have been pointed out: identification of the social communities which set their requirements to the quality and what these requirements are; the ways and the degree of influence of the identified interest groups on the process and the result of education, the relationship between the requirements of these groups. The social effectiveness as a complex characteristic of the school work, such as the level of interaction between educational establishments, administrating authorities and social institutions and social
Samara, Anna; Smith, Kenny; Brown, Helen; Wonnacott, Elizabeth
Languages exhibit sociolinguistic variation, such that adult native speakers condition the usage of linguistic variants on social context, gender, and ethnicity, among other cues. While the existence of this kind of socially conditioned variation is well-established, less is known about how it is acquired. Studies of naturalistic language use by children provide various examples where children's production of sociolinguistic variants appears to be conditioned on similar factors to adults' production, but it is difficult to determine whether this reflects knowledge of sociolinguistic conditioning or systematic differences in the input to children from different social groups. Furthermore, artificial language learning experiments have shown that children have a tendency to eliminate variation, a process which could potentially work against their acquisition of sociolinguistic variation. The current study used a semi-artificial language learning paradigm to investigate learning of the sociolinguistic cue of speaker identity in 6-year-olds and adults. Participants were trained and tested on an artificial language where nouns were obligatorily followed by one of two meaningless particles and were produced by one of two speakers (one male, one female). Particle usage was conditioned deterministically on speaker identity (Experiment 1), probabilistically (Experiment 2), or not at all (Experiment 3). Participants were given tests of production and comprehension. In Experiments 1 and 2, both children and adults successfully acquired the speaker identity cue, although the effect was stronger for adults and in Experiment 1. In addition, in all three experiments, there was evidence of regularization in participants' productions, although the type of regularization differed with age: children showed regularization by boosting the frequency of one particle at the expense of the other, while adults regularized by conditioning particle usage on lexical items. Overall, results
Methodical development of a modular planning and decision-making model for local energy supply concepts with regard to the special conditions which prevail in the new Lands of unified Germany. Methodische Entwicklung eines strukturierten Planungs- und Entscheidungsmodells fuer die Gestaltung integrierter oertlicher Energieversorgungskonzepte unter Beruecksichtigung der besonderen Rahmenbedingungen in den neuen Bundeslaendern
An action-oriented planning and decision-making model considering individual local conditions and general aspects of energy economy is presented for the development of feasible municipal energy supply concepts. The decision-making model was given a modular structure for future knowledge-based energy-economy planning by use of personal computers. The formalized methodology and a corresponding expert system development environment help to implement the developed phase model and give better and more rapid access to the expert knowledge which is relevant to energy economy. (orig.).
Puig-Barrachina, Vanessa; Vanroelen, Christophe; Vives, Alejandra; Martínez, José Miguel; Muntaner, Carles; Levecque, Katia; Benach, Joan; Louckx, Fred
Precarious employment is becoming an increasingly important social determinant of health inequalities among workers. The way in which contemporary employment arrangements and their health consequences are addressed in empirical research is mostly based on the contract-related or employment instability dimension. A broader conceptual approach including various important characteristics of the degrading of employment conditions and relations is needed. The general objective of this paper is to empirically test a new multidimensional construct for measuring precarious employment in an existing database. Special focus is on the social distribution of precarious employment. A subsample of 21,415 participants in the EU-27 from the Fourth European Working Conditions Survey-2005 was analysed. A cross-sectional study of the social distribution of precarious employment was conducted through the analysis of proportional differences according to gender, social class and credentials for the European Union as a whole and within each country. The 8 dimensions of the employment precariousness construct were represented by 11 indicators. In general, women, workers without supervisory authority, those with fewer credentials, and those living in Eastern and Southern European countries suffer the highest levels of precarious employment. Exceptionally, men, workers with supervisory authority and those with the highest credentials suffer the highest levels of long working hours, schedule unpredictability and uncompensated flexible working times. This article offers the first validation for an innovative multidimensional conceptualisation of employment precariousness applied to the analysis of existing survey data, showing the unequal distribution of precarious employment across the European labour force. This set of indicators can be useful for monitoring precarious employment.
Kaiser, Sylvia; Harderthauer, Simone; Sachser, Norbert; Hennessy, Michael B
A recent study found that male guinea pigs raised in large, mixed age/sex groups exhibited an unexpected suppression of their cortisol response at 4 mo of age. The present study examined the effect of social experience around the time of puberty on cortisol response suppression and social behavior at 4 mo of age. Males reared in large, mixed age/sex groups were either pair-housed with a female or moved to another large colony at 55 days of age. When tested at 4 mo, pair-housed males exhibited much higher levels of courtship and sexual behavior than did colony-housed males, and a shorter latency to begin courtship when with an unfamiliar adult female. In addition, pair-housed males showed much higher levels of agonistic behavior and a shorter latency to escalated aggression with an unfamiliar adult male. Pair-housed males also had lower basal cortisol concentrations and exhibited a greater increment in cortisol levels when isolated in a novel cage than did colony-housed males. Finally, pair-housed males showed a smaller increment in cortisol levels when with the stimulus female or male than when isolated, but colony-housed males did not. The findings demonstrate that social housing conditions around the time of puberty can have pervasive effects on social behavior and hypothalamic-pituitary-adrenal (HPA) activity in 4-mo-old males. Further, these findings are consistent with the notion that changes in HPA activity contribute to social behavior development beyond the time of sexual maturity.
Morales, Melissa; Schatz, Kelcie C; Anderson, Rachel I; Spear, Linda P; Varlinskaya, Elena I
Given that human adolescents place a high value on social interactions-particularly while consuming alcohol-the current study utilized a novel social drinking paradigm to examine rewarding and aversive properties of ethanol in non-water deprived rats that were housed and tested in groups of five same-sex littermates. On postnatal day P34 (adolescents) or P69 (adults), rats were habituated to the testing apparatus for 30 min. On the next day, animals were placed into the test apparatus and given 30 min access to a supersaccharin solution (3% sucrose; 0.125% saccharin), followed immediately by an intraperitoneal injection of ethanol (0, 0.25, 0.5, 1.0, 1.5 g/kg). Subsequent intake of the supersacharrin solution was assessed on three consecutive test days. Adolescent males were less sensitive to ethanol's aversive effects than adult males, with adolescent males maintaining an aversion on all three test days only at the 1.5 g/kg dose, whereas adults demonstrated aversions across test days to 1 and 1.5 g/kg. Adolescent females maintained aversions to 1 and 1.5 g/kg across days, whereas adult females continued to show an aversion to the 1.5 g/kg dose only. These opposite patterns of sensitivity that emerged among males and females at each age in the propensity to maintain an ethanol-induced taste aversion under social conditions may contribute to age- and sex-related differences in ethanol intake. Testing in social groups may be useful for future work when studying rodent models of adolescent alcohol use given the importance that human adolescents place on drinking in social settings. Copyright © 2014 Elsevier B.V. All rights reserved.
Malmusi, Davide; Vives, Alejandra; Benach, Joan; Borrell, Carme
Women experience poorer health than men despite their longer life expectancy, due to a higher prevalence of non-fatal chronic illnesses. This paper aims to explore whether the unequal gender distribution of roles and resources can account for inequalities in general self-rated health (SRH) by gender, across social classes, in a Southern European population. Cross-sectional study of residents in Catalonia aged 25-64, using data from the 2006 population living conditions survey (n=5,817). Poisson regression models were used to calculate the fair/poor SRH prevalence ratio (PR) by gender and to estimate the contribution of variables assessing several dimensions of living conditions as the reduction in the PR after their inclusion in the model. Analyses were stratified by social class (non-manual and manual). SRH was poorer for women among both non-manual (PR 1.39, 95% CI 1.09-1.76) and manual social classes (PR 1.36, 95% CI 1.20-1.56). Adjustment for individual income alone eliminated the association between sex and SRH, especially among manual classes (PR 1.01, 95% CI 0.85-1.19; among non-manual 1.19, 0.92-1.54). The association was also reduced when adjusting by employment conditions among manual classes, and household material and economic situation, time in household chores and residential environment among non-manual classes. Gender inequalities in individual income appear to contribute largely to women's poorer health. Individual income may indicate the availability of economic resources, but also the history of access to the labour market and potentially the degree of independence and power within the household. Policies to facilitate women's labour market participation, to close the gender pay gap, or to raise non-contributory pensions may be helpful to improve women's health.
Gkotsis, George; Oellrich, Anika; Velupillai, Sumithra; Liakata, Maria; Hubbard, Tim J P; Dobson, Richard J B; Dutta, Rina
The number of people affected by mental illness is on the increase and with it the burden on health and social care use, as well as the loss of both productivity and quality-adjusted life-years. Natural language\\ud processing of electronic health records is increasingly used to study mental health conditions and risk behaviours on a large scale. However, narrative notes written by clinicians do not capture first-hand\\ud the patients’ own experiences, and only record cross-sectional, professio...
Opoku, Alex Akwasi; Edusei, Kwame Owusu; Ansah, Richard Kwame
This paper proposes a conditional Curie-Weiss model as a model for decision making in a stylized society made up of binary decision makers that face a particular dichotomous choice between two options. Following Brock and Durlauf (Discrete choice with social interaction I: theory, 1955), we set-up both socio-economic and statistical mechanical models for the choice problem. We point out when both the socio-economic and statistical mechanical models give rise to the same self-consistent equilibrium mean choice level(s). Phase diagram of the associated statistical mechanical model and its socio-economic implications are discussed.
Raimundo González Fernández
Full Text Available This article presents a panorama of the necessity the current Cuban society has to form high quality technicians in Computer science, and the social and historical conditions that compromise the existence of the subject “Language of Programming ”inside its study plan, as well as the necessity to upgrade teachers who teach this subject, in Computer Science's Polytechnical School "Carlos Hidalgo Díaz” in Pinar del Río province. Regarding the inadequacies there are in these programs, in the theoretical and methodological order, it is expected that with an intervention strategy consisting on an upgrading course this problem can be solved.
Context The mortality numbers and rates of chronic disease are rising faster in developing than in developed countries. This article compares prevailing explanations of population chronic disease trends with theoretical and empirical models of population chronic disease epidemiology and assesses some economic consequences of the growth of chronic diseases in developing countries based on the experiences of developed countries. Methods Four decades of male mortality rates of cardiovascular and chronic noncommunicable diseases were regressed on changes in and levels of country income per capita, market integration, foreign direct investment, urbanization rates, and population aging in fifty-six countries for which comparative data were available. Neoclassical economic growth models were used to estimate the effect of the mortality rates of chronic noncommunicable diseases on economic growth in high-income OECD countries. Findings Processes of economic growth, market integration, foreign direct investment, and urbanization were significant determinants of long-term changes in mortality rates of heart disease and chronic noncommunicable disease, and the observed relationships with these social and economic factors were roughly three times stronger than the relationships with the population's aging. In low-income countries, higher levels of country income per capita, population urbanization, foreign direct investment, and market integration were associated with greater mortality rates of heart disease and chronic noncommunicable disease, less increased or sometimes reduced rates in middle-income countries, and decreased rates in high-income countries. Each 10 percent increase in the working-age mortality rates of chronic noncommunicable disease decreased economic growth rates by close to a half percent. Conclusions Macrosocial and macroeconomic forces are major determinants of population rises in chronic disease mortality, and some prevailing demographic explanations
The mortality numbers and rates of chronic disease are rising faster in developing than in developed countries. This article compares prevailing explanations of population chronic disease trends with theoretical and empirical models of population chronic disease epidemiology and assesses some economic consequences of the growth of chronic diseases in developing countries based on the experiences of developed countries. Four decades of male mortality rates of cardiovascular and chronic noncommunicable diseases were regressed on changes in and levels of country income per capita, market integration, foreign direct investment, urbanization rates, and population aging in fifty-six countries for which comparative data were available. Neoclassical economic growth models were used to estimate the effect of the mortality rates of chronic noncommunicable diseases on economic growth in high-income OECD countries. Processes of economic growth, market integration, foreign direct investment, and urbanization were significant determinants of long-term changes in mortality rates of heart disease and chronic noncommunicable disease, and the observed relationships with these social and economic factors were roughly three times stronger than the relationships with the population's aging. In low-income countries, higher levels of country income per capita, population urbanization, foreign direct investment, and market integration were associated with greater mortality rates of heart disease and chronic noncommunicable disease, less increased or sometimes reduced rates in middle-income countries, and decreased rates in high-income countries. Each 10 percent increase in the working-age mortality rates of chronic noncommunicable disease decreased economic growth rates by close to a half percent. Macrosocial and macroeconomic forces are major determinants of population rises in chronic disease mortality, and some prevailing demographic explanations, such as population aging, are
Gkotsis, George; Oellrich, Anika; Velupillai, Sumithra; Liakata, Maria; Hubbard, Tim J. P.; Dobson, Richard J. B.; Dutta, Rina
The number of people affected by mental illness is on the increase and with it the burden on health and social care use, as well as the loss of both productivity and quality-adjusted life-years. Natural language processing of electronic health records is increasingly used to study mental health conditions and risk behaviours on a large scale. However, narrative notes written by clinicians do not capture first-hand the patients’ own experiences, and only record cross-sectional, professional impressions at the point of care. Social media platforms have become a source of ‘in the moment’ daily exchange, with topics including well-being and mental health. In this study, we analysed posts from the social media platform Reddit and developed classifiers to recognise and classify posts related to mental illness according to 11 disorder themes. Using a neural network and deep learning approach, we could automatically recognise mental illness-related posts in our balenced dataset with an accuracy of 91.08% and select the correct theme with a weighted average accuracy of 71.37%. We believe that these results are a first step in developing methods to characterise large amounts of user-generated content that could support content curation and targeted interventions.
Fernandez Espejo, Emilio
Prefrontal dopamine loss delays extinction of cued fear conditioning responses, but its role in contextual fear conditioning has not been explored. Medial prefrontal lesions also enhance social interaction in rats, but the role of prefrontal dopamine loss on social interaction memory is not known. Besides, a role for subcortical accumbal dopamine on mnesic changes after prefrontal dopamine manipulation has been proposed but not explored. The objective was to study the involvement of dopaminergic neurotransmission in the medial prefrontal cortex (mPFC) and nucleus accumbens in two mnesic tasks: contextual fear conditioning and social interaction memory. For contextual fear conditioning, short- and long-term freezing responses after an electric shock were studied, as well as extinction retention. Regarding social interaction memory, the recognition of a juvenile, a very sensitive short-term memory test, was used. Dopamine loss was carried out by injection of 6-hydroxydopamine, and postmortem catecholamine levels were analyzed by high-performance liquid chromatography. Prefrontocortical dopamine loss (>76%) led to a reactive enhancement of accumbal dopamine content (ploss. In lesioned rats, long-term extinction of contextual fear conditioning was significantly delayed and extinction retention was impaired without changes in acquisition and short-term contextual fear conditioning and, on the other hand, acquisition and short-term social interaction memory were not affected, although time spent on social interaction was significantly reduced. Added dopamine loss in the nucleus accumbens (>76%) did not alter these behavioral changes. In summary, the results of the present study indicate that the dopaminergic network in the mPFC (but not in the nucleus accumbens) coordinates the normal long-term extinction of contextual fear conditioning responses without affecting their acquisition, and it is involved in time spent on social interaction, but not acquisition and short
Kauhanen, L; Lynch, J W; Lakka, H-M; Kauhanen, J; Smith, G D
Previous research has suggested that dehydration in infancy may lead to high blood pressure in later life because of sodium retention. The purpose of this study was to examine the effect of poor hygiene of the child, poor social and poor housing conditions at home and diarrhoea in childhood as proxies for dehydration on high blood pressure in later life. Data were from a subset of participants in the Kuopio Ischaemic Heart Disease Risk Factor Study, a population-based cohort study in eastern Finland. Information on childhood factors was collected from school health records (n=952), from the 1930s to the 1950s. Adult data were obtained from baseline examinations of the Kuopio Ischaemic Heart Disease Risk Factor Study cohort (n=2682) in 1984-1989. Men who had poor hygiene in childhood had on average 4.07 mm Hg (95% CI 0.53 to 7.61) higher systolic blood pressure than men who had good or satisfactory hygiene in childhood in the age-adjusted analysis. Reports of diarrhoea were not associated with adult blood pressure. The authors' findings suggest that poor hygiene and living in poor social conditions in childhood are associated with higher systolic blood pressure in adulthood. Reported childhood diarrhoea did not explain the link between hygiene and high blood pressure in adulthood.
Robles, Cindee F.; McMackin, Marissa Z.; Campi, Katharine L.; Doig, Ian E.; Takahashi, Elizabeth Y.; Pride, Michael; Trainor, Brian C.
The effects of kappa opioid receptors (KOR) on motivated behavior are well established based on studies in male rodents, but relatively little is known about the effects of KOR in females. We examined the effects of KOR activation on conditioned place aversion and social interaction in the California mouse (Peromyscus californicus). Important differences were observed in long-term (place aversion) and short-term (social interaction) effects. Females but not males treated with a 2.5mg/kg dose of U50,488 formed a place aversion, whereas males but not females formed a place aversion at the 10 mg/kg dose. In contrast the short term effects of different doses of U50,488 on social interaction behavior were similar in males and females. Acute injection with 10 mg/kg of U50,488 (but not lower doses) reduced social interaction behavior in both males and females. The effects of U50,488 on phosphorylated extracellular signal regulated kinase (pERK) and p38 MAP kinase were cell type and region specific. Higher doses of U50,488 increased the number of pERK neurons in the ventrolateral bed nucleus of the stria terminals in males but not females, a nucleus implicated in male aggressive behavior. In contrast, both males and females treated with U50,488 had more activated p38 cells in the nucleus accumbens shell. Unexpectedly, cells expressing activated p38 co-expressed Iba-1, a widely used microglia marker. In summary we found strong sex differences in the effects of U50,488 on place aversion whereas the acute effects on U50,488 induced similar behavioral effects in males and females. PMID:24445073
Mooney, S J; Holmes, M M
The naked mole-rat is a subterranean colonial rodent. In each colony, which can grow to as many as 300 individuals, there is only one female and 1-3 males that are reproductive and socially dominant. The remaining animals are reproductively suppressed subordinates that contribute to colony survival through their cooperative behaviors. Oxytocin is a peptide hormone that has shown relatively widespread effects on prosocial behaviors in other species. We examined whether social status affects the number of oxytocin-immunoreactive neurons in the paraventricular nucleus and the supraoptic nucleus by comparing dominant breeding animals to subordinate non-breeding workers from intact colonies. We also examined these regions in subordinate animals that had been removed from their colony and paired with an opposite- or same-sex conspecific for 6 months. Stereological analyses indicated that subordinates had significantly more oxytocin neurons in the paraventricular nucleus than breeders. Animals in both opposite- and same-sex pairs showed a decreased oxytocin neuron number compared to subordinates suggesting that status differences may be due to social condition rather than the reproductive activity of the animal per se. The effects of social status appear to be region specific as no group differences were found for oxytocin neuron number in the supraoptic nucleus. Given that subordinate naked mole-rats are kept reproductively suppressed through antagonism by the queen, we speculate that status differences are due either to oxytocin's anxiolytic properties to combat the stress of this antagonism or to its ability to promote the prosocial behaviors of subordinates. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
Tantra, M; Guo, L; Kim, J; Zainolabidin, N; Eulenburg, V; Augustine, G J; Chen, A I
Inhibitory interneurons mediate the gating of synaptic transmission and modulate the activities of neural circuits. Disruption of the function of inhibitory networks in the forebrain is linked to impairment of social and cognitive behaviors, but the involvement of inhibitory interneurons in the cerebellum has not been assessed. We found that Cadherin 13 (Cdh13), a gene implicated in autism spectrum disorder and attention-deficit hyperactivity disorder, is specifically expressed in Golgi cells within the cerebellar cortex. To assess the function of Cdh13 and utilize the manipulation of Cdh13 expression in Golgi cells as an entry point to examine cerebellar-mediated function, we generated mice carrying Cdh13-floxed alleles and conditionally deleted Cdh13 with GlyT2::Cre mice. Loss of Cdh13 results in a decrease in the expression/localization of GAD67 and reduces spontaneous inhibitory postsynaptic current (IPSC) in cerebellar Golgi cells without disrupting spontaneous excitatory postsynaptic current (EPSC). At the behavioral level, loss of Cdh13 in the cerebellum, piriform cortex and endopiriform claustrum have no impact on gross motor coordination or general locomotor behaviors, but leads to deficits in cognitive and social abilities. Mice lacking Cdh13 exhibit reduced cognitive flexibility and loss of preference for contact region concomitant with increased reciprocal social interactions. Together, our findings show that Cdh13 is critical for inhibitory function of Golgi cells, and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain, such as the cerebellum, may contribute to cognitive and social behavioral deficits linked to neurological disorders. © 2018 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.
Penagos-Corzo, Julio C.; Pérez-Acosta, Andrés M.; Hernández, Ingrid
The experiment reported here uses a conditional self-discrimination task to examine the influence of social interaction on the facilitation of self-discrimination in rats. The study is based on a previous report (Penagos- Corzo et al., 2011) showing positive evidence of such facilitation, but extending the exposition to social interaction…
Super, S.; Verkooijen, K.T.; Koelen, M.A.
Sport is widely recognised as having the potential to enhance the personal development of socially vulnerable youth, yet there is very limited knowledge on how community sports coaches can create optimal social conditions for life skill development and transferability. We adopt a salutogenic
C. E. Plotnikova
Full Text Available The change in the conditions of the person's life activity and its innovative mentality intensified the problems of personal and professional self-determination. The senior school age is a period of primary, ambivalent options. At this age, the foundations of the moral attitude to different kinds of work are laid, the formation of a system of personal values that determine the selectivity of the attitude of high school students to various professions. The purpose of the study was to study the socio-pedagogical conditions for the vocational guidance of high school students. The object of research is the professional orientation of high school students. The subject of the study is the design of the socio-pedagogical conditions for the vocational guidance of high school students. The article analyzes the following social and pedagogical conditions for the vocational guidance of high school students: the development of individual abilities of schoolchildren, the expansion of differentiated education in accordance with their inclinations and educational needs, the development of a network of specialized classes with in-depth study of various subjects, ensuring the level of secondary education meets the requirements of scientific and technological progress. The authors emphasize that vocational guidance is one of the key functions of a basic school in modern conditions. It is the activities of vocational guidance that contribute to the adequate professional choice of schoolchildren, which gives them further success in life, and the labor market - specialists of the required quality and in the required quantity. Consequently, the effectiveness of this work requires regular evaluation through interviews with high-school students aimed at identifying their vocational and educational orientations and assessing the quality of career counseling services. Such studies are necessary to improve the quality of vocational guidance work carried out by schools.
Bregolin, Tanja; Pinheiro, Barbara S; El Rawas, Rana; Zernig, Gerald
The reorientation away from drugs of abuse and toward social interaction is a highly desirable but as yet elusive goal in the therapy of substance dependence. We could previously show that cocaine preferring Sprague-Dawley rats which engaged in only four 15 min episodes of dyadic social interaction (DSI) did not reacquire and reexpress cocaine conditioned place preference (CPP) after a single cocaine exposure. In the present study, we investigated how strong this preventive effect of DSI is. In corroboration of our previous findings in rats, four 15 min DSI episodes prevented the reacquisition/reexpression of cocaine CPP in mice. However, this effect was only observed if only one cocaine conditioning session (15 min) was used. If mice were counterconditioned with a total of four cocaine sessions, the cocaine CPP reemerged. Interestingly, the opposite also held true: in mice that had acquired/expressed cocaine CPP, one conditioning session with DSI did not prevent the persistence of cocaine CPP, whereas four DSI conditioning sessions reversed CPP for 15 mg/kg intraperitoneal cocaine. Of note, this cocaine dose was a strong reward in C57BL/6J mice, causing CPP in all tested animals. Our findings suggest that both the reversal (reconditioning) of CPP from cocaine to DSI as well as that from DSI to cocaine requires four conditioning sessions. As previously shown in C57BL/6 mice from the NIH substrain, mice from the Jackson substrain also showed a greater relative preference for 15 mg/kg intraperitoneal cocaine over DSI, whereas Sprague-Dawley rats were equally attracted to contextual stimuli associated with this cocaine dose and DSI. Also in corroboration of previous findings, both C57BL/6J mice and experimenters several generations removed from the original ones produced CPP for DSI to a lesser degree than Sprague-Dawley rats. Our findings demonstrate the robustness of our experimental model across several subject- and experimenter generations in two rodent genus (i
Full Text Available The reorientation away from drugs of abuse and toward social interaction is a highly desirable but as yet elusive goal in the therapy of substance dependence. We could previously show that cocaine preferring Sprague-Dawley rats which engaged in only four 15 min episodes of dyadic social interaction (DSI did not reacquire and reexpress cocaine conditioned place preference (CPP after a single cocaine exposure. In the present study, we investigated how strong this preventive effect of DSI is. In corroboration of our previous findings in rats, four 15 min DSI episodes prevented the reacquisition/reexpression of cocaine CPP in mice. However, this effect was only observed if only one cocaine conditioning session (15 min was used. If mice were counterconditioned with a total of four cocaine sessions, the cocaine CPP reemerged. Interestingly, the opposite also held true: in mice that had acquired/expressed cocaine CPP, one conditioning session with DSI did not prevent the persistence of cocaine CPP, whereas four DSI conditioning sessions reversed CPP for 15 mg/kg intraperitoneal cocaine. Of note, this cocaine dose was a strong reward in C57BL/6J mice, causing CPP in all tested animals. Our findings suggest that both the reversal (reconditioning of CPP from cocaine to DSI as well as that from DSI to cocaine requires four conditioning sessions. As previously shown in C57BL/6 mice from the NIH substrain, mice from the Jackson substrain also showed a greater relative preference for 15 mg/kg intraperitoneal cocaine over DSI, whereas Sprague-Dawley rats were equally attracted to contextual stimuli associated with this cocaine dose and DSI. Also in corroboration of previous findings, both C57BL/6J mice and experimenters several generations removed from the original ones produced CPP for DSI to a lesser degree than Sprague-Dawley rats. Our findings demonstrate the robustness of our experimental model across several subject- and experimenter generations in two
Nemeth, Matthias; Millesi, Eva; Puehringer-Sturmayr, Verena; Kaplan, Arthur; Wagner, Karl-Heinz; Quint, Ruth; Wallner, Bernard
Unbalanced dietary intakes of saturated (SFAs) and polyunsaturated (PUFAs) fatty acids can profoundly influence the hypothalamic-pituitary-adrenal (HPA)-axis and glucocorticoid secretions in relation to behavioral performances. The beneficial effects of higher dietary PUFA intakes and PUFA:SFA ratios may also affect social interactions and social-living per se, where adequate physiological and behavioral responses are essential to cope with unstable social environmental conditions. Effects of diets high in PUFAs or SFAs and a control diet were investigated in male and female guinea pigs after 60 days of supplementation. Plasma fatty acid patterns served as an indicator of the general fatty acid status. HPA-axis activities, determined by measuring saliva cortisol concentrations, social behaviors, and hierarchy ranks were analyzed during group housing of established single-sexed groups and during challenging social confrontations with unfamiliar individuals of the other groups. The plasma PUFA:SFA ratio was highest in PUFA supplemented animals, with female levels significantly exceeding males, and lowest in SFA animals. SFA males and females showed increased saliva cortisol levels and decreased aggressiveness during group housing, while sociopositive behaviors were lowest in PUFA males. Males generally showed higher cortisol increases in response to the challenging social confrontations with unfamiliar individuals than females. While increasing cortisol concentrations were detected in control and PUFA animals, no such effect was found in SFA animals. During social confrontations, PUFA males showed higher levels of agonistic and sociopositive behaviors and also gained higher dominance ranks among males, which was not detected for females. While SFAs seemingly impaired cortisol responses and social behaviors, PUFAs enabled adequate behavioral responses in male individuals under stressful new social environmental conditions. This sex-specific effect was possibly
Moerner, N.A. [Stockholm Univ. (Sweden)
The conclusions from this contribution are that no bedrock repository can be considered to be safely placed in the bedrock at the event of new glaciations, which are to be expected over Sweden in 5, 23, and 60 thousand years AP (following the astronomical, natural or long-term variability). Instead, there are all reasons to expect that such a repository would be seriously damaged, and constitute a threat to the biosphere on Earth. These conclusions are based on an extensive observational network of records on the multiple glacial dynamics and the interaction of different variables. 24 refs.
Measurements were made of I/sub 2/ formed when aqueous cesium iodide (CsI) solutions were exposed to two temperatures, 43 and 95 0 C, with irradiation. Iodine partition coefficients were obtained from the experiments. The parameters varied were dose, CsI concentration, and Cs/sub 2/CO/sub 3/ concentration, in the presence of air-carbon dioxide and air-carbon dioxide-hydrogen mixtures, to provide information to calculate the form in which iodine released from fuel as CsI in a reactor accident might reach the environment. In a series of experiments, a two-compartment cell was used to trap the gaseous iodine produced. In this case, it was found that the quantity of gaseous iodine produced increased approximately linearly with the dose (at the dose rate used)
MacKay, R.; Cooper, T.A.; Porter, J.D.; O'Connell, P.E.; Metcalfe, A.V.
A geostatistical approach is applied in a study of the potential migration of contaminants from a hypothetical waste disposal facility near Elstow, Bedfordshire. A deterministic numerical model of groundwater flow in the Kellaways Sands formation and adjacent layers is coupled with geostatistical simulation of the heterogeneous transmissivity field of this principal formation. A particle tracking technique is used to predict the migration pathways for alternative realisations of flow. Alternative statistical descriptions of the spatial structure of the transmissivity field are implemented and the temporal and spatial distributions of escape of contaminants to the biosphere are investigated. (author)
The conclusions from this contribution are that no bedrock repository can be considered to be safely placed in the bedrock at the event of new glaciations, which are to be expected over Sweden in 5, 23, and 60 thousand years AP (following the astronomical, natural or long-term variability). Instead, there are all reasons to expect that such a repository would be seriously damaged, and constitute a threat to the biosphere on Earth. These conclusions are based on an extensive observational network of records on the multiple glacial dynamics and the interaction of different variables. 24 refs
Tassino, Bettina; Horta, Stefany; Santana, Noelia; Levandovski, Rosa; Silva, Ana
In humans, a person's chronotype depends on environmental cues and on individual characteristics, with late chronotypes prevailing in youth. Social jetlag (SJL), the misalignment between an individual׳s biological clock and social time, is higher in late chronotypes. Strong SJL is expected in Uruguayan university students with morning class schedules and very late entertainment activities. Sleep disorders have been reported in Antarctic inhabitants, that might be a response to the extreme environment or to the strictness of Antarctic life. We evaluated, for the first time in Uruguay, the chronotypes and SJL of 17 undergraduate students of the First Uruguayan Summer School on Antarctic Research, using Munich Chronotype Questionnaire (MCTQ) and sleep logs (SL) recorded during 3 phases: pre-Antarctic, Antarctic, and post-Antarctic. The midsleep point of free days corrected for sleep debt on work days (MSFsc,) was used as proxy of individuals' chronotype, whose values (around 6 a.m.) are the latest ever reported. We found a SJL of around 2 h in average, which correlated positively with MSFsc, confirming that late chronotypes generate a higher sleep debt during weekdays. Midsleep point and sleep duration significantly decreased between pre-Antarctic and Antarctic phases, and sleep duration rebounded to significant higher values in the post-Antarctic phase. Waking time, but not sleep onset time, significantly varied among phases. This evidence suggests that sleep schedules more likely depended on the social agenda than on the environmental light-dark shifts. High motivation of students towards Antarctic activities likely induced a subjective perception of welfare non-dependent on sleep duration.
Burton-Chase, Allison M; Parker, Wendy M; Hennig, Kelsey; Sisson, Faith; Bruzzone, Linda L
Social media is increasingly being used as a means of recruiting participants, particularly for investigators whose areas of interest involve rare conditions or hard-to-reach populations. However, much of the literature to date has focused on paid advertisement recruitment. We used Lynch syndrome (LS), a rare hereditary cancer syndrome, as a model to demonstrate the successful partnership between researchers and a Web-based patient education and advocacy organization to facilitate participant recruitment. Recruitment was undertaken in partnership with Lynch Syndrome International (LSI), an advocacy organization with a strong social media presence. After LSI published our study information, participants followed up via email or phone call. Following prescreening and consent, interested and eligible participants were then sent a secure survey link. Within 36 hours of a single Facebook post by the site administrators for LSI, over 150 individuals responded via phone or email. Sixty-five individuals were sent the survey link and 57 individuals completed the survey (88% response rate). Of note, these 57 individuals were geographically diverse within the Unites States, representing LS patients from 26 different states. This approach has several advantages, including recruitment through a trusted source outside of a clinical setting, higher response rates, and cost-effectiveness with a small research team in a relatively short amount of time. Overall, social media recruitment with a trusted online partner can be highly effective in hard-to-reach clinical populations, such as patients with LS. However, this approach requires additional effort for eligibility screening. ©Allison M Burton-Chase, Wendy M Parker, Kelsey Hennig, Faith Sisson, Linda L Bruzzone. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 23.01.2017.
Full Text Available The paper addresses the issue of maintaining psychological well-being in individuals who have experienced critical events. The research presented in this paper was carried out within the paradigm of salutogenesis, according to which the most crucial factors in preserving one’s mental and physical health are the realization of the inner potential, cognitive and physical activity, orientation towards healthy life goals, and self-actualization, and not only the absence of illness and disabilities. The authors describe a procedure of methodological triangulation of quantitative and qualitative data that enabled them to outline the social psychological conditions necessary for the positive functioning of individuals who have experienced critical events.
Carmen Helena Guerrero
Full Text Available This article aims at contributing to the ongoing discussion about how bilingualism is understood in the current National Bilingualism Plan (PNB for its initials in Spanish. Based on previous research and discussions held at academic events, it is evident that the promoters of the PNB use the term “bilingualism” in a rather indiscriminate way, without adopting a clear approach or definition. This ambiguity in conceptualization has serious consequences in the way the PNB is implemented around the country. The main contribution of this reflection article is, then, to explore from a theoretical perspective two opposite types of bilingualism: elite/folk bilingualism to show that even though on the surface the PNB seems to aim at an elite bilingualism, the educational and social conditions show otherwise.
Kopyta, Ilona; Szwed-Białozyt, Barbara; Czardybon, Magdalena; Drzyzdzyk, Kinga; Kałuzna-Czyz, Monika; Korczyk, Radosław; Kozieł, Paweł
A tic is a rapid, involuntary and stereotypical motor movement or vocalization. The exact cause of tic disorder is unknown, but it is well established that both genetic and environmental factors are involved. Tic occurence in population was estimated on 5-100/10 000. The purpose of the research was to analyze the clinical symptoms and social conditionings of tic disorder in children. The analysis was conducted on a group of 42 patients (8 girls, 34 boys) at the age of 3 to 15 years, admitted to Department of Neuropediatric of Medical University of Silesia to diagnose and treatment of tic disorder. The children's family history was analyzed. The patients were physically, neurogically, radiologically and psychologically examined. The majority group were boys and the time of the symptoms appearance was an early school age. The tics were associated with emotional and anxiety disorders, compulsive behavior, psychological obsession. 9% of patients had family history of tic disorder. Pregnancy-birth history was complicated in 24% of cases. There were not abnormalities in physical, neurological and radiological examination in most cases. The majority group (83%) lives in the cities. The most parents have vocational training. In case of appearance of twitching during suspicious behavior of child, we need to carry out a inquiring research targeted to widely understated social issues.
dos Reis, Dener Carlos; de Almeida, Thiara Amanda Corrêa; Miranda, Mariane Mendes; Alves, Rodrigo Henrique; Madeira, Anézia Moreira Faria
to analyze the health vulnerabilities in adolescence associated with socioeconomic conditions, social networks, drugs and violence from the perspective of students. cross-sectional study with 678 students between 14-15 years old in Contagem, Brazil. A self-administered questionnaire divided into modules by subject was used. Quantitative, descriptive and stratified analyses were performed by sex. high percentage of adolescents (40.4%) were beneficiaries of Government financial support called "Bolsa Família" and 14.6% had a job, 57.1% and 23.6% had tried alcohol and tobacco, respectively. We identified 15% of aggression and 26.7% of bullying. The majority informed they never/rarely talk to parents about the daily difficulties (64.5%) and 22% reported insomnia and/or feelings of loneliness. the results indicated that there is a need to intensify educational activities that seek to develop cognitive, affective and social skills aimed at improving the way adolescents face the vulnerabilities, in these activities, nursing has a fundamental role.
E. F. Zeyer
Full Text Available The paper discusses the peculiarities of students’ professional identity in the context of socially conditioned conflicting realities. The individual social position is of a particular importance for the professional identity formation, so the authors carried out the research into the students professional self-determination with the reference to their socio-metric status in the academic group; the interpersonal relations were considered as conflict- generating – provoking the conflicting realities of students’ professional self- determination. The theoretical basis of the study involves the concept of personal professional growth with the emphasis on the students’ self-determination in the conflict situations. The research methodology combines the diagnostics of professional self-determination and socio-metric methods. The analysis and synthesis of the acquired empirical data reveal the differences in the expressed levels of components of the students’ professional identity according to their socio-metric status in the group. The research findings include the conformity of conflicting realities arising in interpersonal relationships in the academic process and reflected in the professional identity transformation. The above results can be used for psychological facilitation of students’ successful professional growth.
... minimum wage requirements in determining prevailing rates. 532.205 Section 532.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.205 The use of Federal, State, and local minimum wage requirements in determining prevailing...
Allen, M T; Handy, J D; Blankenship, M R; Servatius, R J
Recent work has focused on a learning diathesis model in which specific personality factors such as behavioral inhibition (BI) may influence associative learning and in turn increase risk for the development of anxiety disorders. We have found in a series of studies that individuals self-reporting high levels of BI exhibit enhanced acquisition of conditioned eyeblinks. In the study reported here, hypotheses were extended to include distressed (Type D) personality which has been found to be related to BI. Type D personality is measured with the DS-14 scale which includes two subscales measuring negative affectivity (NA) and social inhibition (SI). We hypothesized that SI, which is similar to BI, would result in enhanced acquisition while the effect of NA is unclear. Eighty nine participants completed personality inventories including the Adult Measure of Behavioral Inhibition (AMBI) and DS-14. All participants received 60 acquisition trials with a 500 ms, 1000 Hz, tone CS and a co-terminating 50 ms, 5 psi corneal airpuff US. Participants received either 100% CS-US paired trials or a schedule of partial reinforcement where 50% US alone trials were intermixed into CS-US training. Acquisition of CRs did not differ between the two training protocols. Whereas BI was significantly related to Type D, SI, and NA, only BI and SI individuals exhibited enhanced acquisition of conditioned eyeblinks as compared to non-inhibited individuals. Personality factors now including social inhibition can be used to identify individuals who express enhanced associative learning which lends further support to a learning diathesis model of anxiety disorders. Copyright © 2018 Elsevier B.V. All rights reserved.
... 7 Agriculture 2 2010-01-01 2010-01-01 false Lower class of two samples to prevail. 27.35 Section 27.35 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... Micronaire Determinations § 27.35 Lower class of two samples to prevail. In case a sample drawn from one...
... OFFICE OF PERSONNEL MANAGEMENT 5 CFR Part 532 RIN 3206-AM84 Prevailing Rate Systems; Redefinition of the Clayton-Cobb-Fulton, Georgia, Nonappropriated Fund Federal Wage System Wage Area AGENCY: U.S... Counties). The Federal Prevailing Rate Advisory Committee, the national labor-management committee...
... of Personnel Management Building, 1900 E Street, NW., Washington, DC. The Federal Prevailing Rate... business. Therefore, these caucuses will be closed to the public because of a determination made by the..., Federal Prevailing Rate Advisory Committee, Room 5H27, 1900 E Street, NW., Washington, DC 20415, (202) 606...
Biquand, Sylvain; Zittel, Benoit
Corporate Social Responsibility (CSR) is now considered in large and global companies and the recent publication of the ISO 26000 standard clarifies the targets. Based on our consultancy's experience for fifteen years in ergonomics mainly in French small and medium enterprises, we developed a label to coax and value efforts of companies in dealing with health and safety at the work place as required by ISO 26000 paragraph 6.4. The formal approach of ISO describes what should be achieved but gives no cue on how actual conditions of work should be improved. The label, called Démarche T (ie Process W where W stands for work) aims the management of work conditions as a process, giving visibility and credit to companies for their continuous involvement in the matter. We describe the items and processes that are part of our assessment. We first conduct an ergonomic diagnosis including the analysis of records on health, physical and psychological well-being, observations at the workplace and interviews with the workers. This diagnosis is followed by recommendations. The fulfillment of these is assessed yearly. Items under assessment include: - ergonomics, health and safety in the companies statements and their impact in actual project management; - relations with workers through the committee for health and safety; - actual results on health, safety and work conditions. On a local level, we give the companies passing the label a competitive edge in recruiting better candidates motivated by good work conditions, and help them fulfill ISO 26000 requirements, an increasingly decisive advantage to benefit from public regional and European support. Our paper describes the diagnosis and follow-up process.
Full Text Available This paper discusses the general problem of territorialization and the special problems of cultural-genetical conditions in the sociological construction of social capital. The starting base is presented by the fact that a connection between the social-ecological conditions of an environment and social capital is historical, permanent and crucial. High and continuous growing level of urbanization in Vojvodina shows the prevailing of urban society inside of which the social capital is being formed. However, in the conditions of social transition also appear controversial relations which exert influence on the creation and functioning of social capital. Social-economical structure of the urban population in Vojvodina and the governing systems of values do not necessary product also the urban way of life, which therefore exerts influence on the quality of social capital. In this paper is particularly examined a connection of the spatial mobility of the urban population, institutional channels and local conditions in the social construction of social capital.
Full Text Available In this review article, the different conditions of the environment which could affect the well-being of the populations living on it are taken into consideration and analysed. A specific attention is paid to the phenomenon of water reduction, land degradation and consequent desertification. Such a phenomenon is particularly worrying in selected regions of the world (the Mediterranean Region and Central Asia in which a combination of several factors including climate variations, pressure of populations and increased competition for the available resources have a direct consequence on the economical, social and political conditions of the population. In addition, migrations could also take place, increasing the instability of entire regions. A proper management of water resources and the preservation of land and soil resources are essential requisites to counteract the mentioned adverse effects. Such a management is frequently a transboundary concern since it might involve different regions and countries; this is an additional reason for debating the environment degradation issues at the international level and for increasing the awareness of the civil society, the policy makers and governments.
Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann
Despite being widely accepted and applied across research domains, maturity models have been criticized for lacking academic rigor, especially methodologically rigorous and empirically grounded or tested maturity models are quite rare. Attempting to close this gap, we adopt a set-theoretic approach...... and evaluate some of arguments presented by previous conceptual focused social media maturity models....... by applying the Necessary Condition Analysis (NCA) technique to derive maturity stages and stage boundaries conditions. The ontology is to view stages (boundaries) in maturity models as a collection of necessary condition. Using social media maturity data, we demonstrate the strength of our approach...
M. A. Gurina
Full Text Available The article deals with the organization management based on the strategy of social responsibility implementation that supplies the conditions for a company's competitiveness development. The theoretical statements by the leading foreign researchers about the key role of social factors in an organization success and the main conditions of competitiveness such as human resources, staff competences, customers' pleasure, an organization's reputation, organizational and managing capacity, etc. The author discusses the idea of the new aim of the management paradigm is "social business" development in the economy. Despite the fact that entrepreneurship is still based on getting the economical benefit, the competitive area, the methods and the relationship between the profit and the competitiveness have changed in the post-industrial era. The change of the consuming society structure and the complication of the competitive area make us look for other sources of competitiveness, such as investments into the human resources. Such an approach to competitiveness is more and more spread among the foreign and national companies and allows to include social aspects management into the development strategy of a company. It is stated that a socially responsible company includes social goals in the production process, thus ensuring a competitive advantage in business. An important conclusion of the research is that socially responsible organizations create better conditions for the territories’ development where they provide the society with a generally higher welfare level.
Nigeria as a Nation is besieged with several national issues such as insecurity of life and property, kidnapping, robbery assassination etc. This problem has brought about retrogressiveness to sustainable national development. Based on this prevailing condition the paper try to examine how the knowledge of social studies ...
Pereira, Susana; Ramos, Alexandre M.; Zêzere, José L.; Trigo, Ricardo M.; Vaquero, José M.
According to the Disaster database (Zêzere et al., 2014), a Disaster event is a set of flood and landslide cases sharing the same trigger, which may have a widespread spatial extension and a certain magnitude. The Disaster event with the highest number of floods and landslides cases occurred in Portugal in the period 1865-2010 was registered between 20 and 28 December 1909. This event also caused important socioeconomic impacts over the Spanish territory, especially in the Douro basin and in the northern section of the Tagus basin. Despite such widespread impact in western Iberia there is no scientific publication addressing the triggering conditions and the social consequences of this disastrous event. Therefore, this work aims to characterize the spatial distribution and social impacts of the December 1909 hydro-geomorphologic event over Iberia. In addition, the meteorological conditions that triggered the event are analysed using the 20 Century Reanalysis dataset from NOAA and rainfall data from Iberian meteorological stations. The historical data source used to analyse the event of December 1909 in Portugal is the Disaster Database (Zêzere et al., 2014). This database contains detailed data on the spatial location and social impacts (fatalities, injuries, missing people, evacuated and homeless people) of hydro-geomorphologic disasters (flood and landslide cases) occurred in Portugal (1865-2010) and referred in newspapers. In Spain the data collection process was supported by the systematic analysis of daily newspapers and using the same entry criteria of the Disaster database, to ensure data integrity and enable comparison with Portuguese records. The Iberian Peninsula was spatially affected during this event along the SW-NE direction spanning between Lisbon, Santarém, Porto and Guarda (in Portugal), until Salamanca, Valladolid, Zamora, Orense, León, Palencia (in Spain). The social and economic impacts of the December 1909 disaster event were higher on the
In order to adequately understand the foundations of human social interaction, we need to provide an explanation of our specific mode of living based on linguistic activity and the cultural practices with which it is interwoven. To this end, we need to make explicit the constitutive conditions for the emergence of the phenomena which relate to language and joint activity starting from their operational-relational matrix. The approach presented here challenges the inadequacy of mentalist models to explain the relation between language and interaction. Recent empirical studies concerning joint attention and language acquisition have led scholars such as Tomasello et al. (2005) to postulate the existence of a universal human "sociocognitive infrastructure" that drives joint social activities and is biologically inherited. This infrastructure would include the skill of precocious intention-reading, and is meant to explain human linguistic development and cultural learning. However, the cognitivist and functionalist assumptions on which this model relies have resulted in controversial hypotheses (i.e., intention-reading as the ontogenetic precursor of language) which take a contentious conception of mind and language for granted. By challenging this model, I will show that we should instead turn ourselves towards a constitutive explanation of language within a "bio-logical" understanding of interactivity. This is possible only by abandoning the cognitivist conception of organism and traditional views of language. An epistemological shift must therefore be proposed, based on embodied, enactive and distributed approaches, and on Maturana's work in particular. The notions of languaging and observing that will be discussed in this article will allow for a bio-logically grounded, theoretically parsimonious alternative to mentalist and spectatorial approaches, and will guide us towards a wider understanding of our sociocultural mode of living.
Full Text Available In order to adequately understand the foundations of human social interaction, we need to provide an explanation of our specific mode of living based on linguistic activity and the cultural practices with which it is interwoven. To this end, we need to make explicit the constitutive conditions for the emergence of the phenomena which relate to language and joint activity starting from their operational-relational matrix. The approach presented here challenges the inadequacy of mentalist models to explain the relation between language and interaction. Recent empirical studies concerning joint attention and language acquisition have led scholars such as Tomasello and his colleagues to postulate the existence of a universal human sociocognitive infrastructure that drives joint social activities and is biologically inherited. This infrastructure would include the skill of precocious intention-reading, and is meant to explain human linguistic development and cultural learning. However, the cognitivist and functionalist assumptions on which this model relies have resulted in controversial hypotheses (i.e., intention-reading as the ontogenetic precursor of language which take a contentious conception of mind and language for granted. By challenging this model, I will show that we should instead turn ourselves towards a constitutive explanation of language within a bio-logical understanding of interactivity. This is possible only by abandoning the cognitivist conception of organism and traditional views of language. An epistemological shift must therefore be proposed, based on embodied, enactive and distributed approaches, and on Maturana’s work in particular. The notions of languaging and observing that will be discussed in this article will allow for a bio-logically grounded, theoretically parsimonious alternative to mentalist and spectatorial approaches, and will guide us towards a wider understanding of our sociocultural mode of living.
Hoyer, J; Kunst, H; Schmidt, A
Studies on the prevalence of social anxiety in sex offenders show mixed results. This may be due to social anxiety being heightened only in diagnostic subgroups of sex offenders, namely in paraphiliacs. In study 1, 72 mentally disordered sexual delinquents and 30 controls were screened for social anxiety with the Social Interaction Anxiety Scale and the Social Phobia Scale by Mattick and Clarke (German versions). In study 2, 55 mentally disordered sexual delinquents were diagnosed with a structured clinical interview. In both studies, sex offenders were categorized as either paraphilic or impulse control disordered (without paraphilia) according to research criteria. Study 1 showed markedly heightened scores for social anxiety in paraphiliacs, particularly for social interaction anxiety. Study 2 found a high lifetime and point prevalence of social phobia in paraphiliacs for which corroborating evidence was again found in questionnaire results. Implications for further research, diagnostic procedures, and therapy are discussed.
Robillard, Julie M; Roskams-Edris, Dylan; Kuzeljevic, Boris; Illes, Judy
Gene therapy research is advancing rapidly, and hopes of treating a large number of brain disorders exist alongside ethical concerns. Most surveys of public attitudes toward these ethical issues are already dated and the content of these surveys has been researcher-driven. To examine current public perceptions, we developed an online instrument that is responsive and relevant to the latest research about ethics, gene therapy, and the brain. The 16-question survey was launched with the platform Amazon Mechanical Turk and was made available to residents of Canada and the United States. The survey was divided into six themes: (1) demographic information, (2) general opinions about gene therapy, (3) medical applications of gene therapy, (4) identity and moral/belief systems, (5) enhancement, and (6) risks. We received and analyzed responses from a total of 467 participants. Our results show that a majority of respondents (>90%) accept gene therapy as a treatment for severe illnesses such as Alzheimer disease, but this receptivity decreases for conditions perceived as less severe such as attention deficit hyperactivity disorder (79%), and for nontherapeutic applications (47%). The greatest area of concern for the application of gene therapy to brain conditions is the fear of not receiving sufficient information before undergoing the treatment. The main ethical concerns with enhancement were the potential for disparities in resource allocation, access to the procedure, and discrimination. When comparing these data with those from the 1990s, our findings suggest that the acceptability of gene therapy is increasing and that this trend is occurring despite lingering concerns over ethical issues. Providing the public and patients with up-to-date information and opportunities to engage in the discourse about areas of research in gene therapy is a priority.
de Snyder, V Nelly Salgado; Friel, Sharon; Fotso, Jean Christophe; Khadr, Zeinab; Meresman, Sergio; Monge, Patricia; Patil-Deshmukh, Anita
The process of urbanization entails social improvements with the consequential better quality-of-life for urban residents. However, in many low-income and some middle-income countries, urbanization conveys inequality and exclusion, creating cities and dwellings characterized by poverty, overcrowded conditions, poor housing, severe pollution, and absence of basic services such as water and sanitation. Slums in large cities often have an absence of schools, transportation, health centers, recreational facilities, and other such amenities. Additionally, the persistence of certain conditions, such as poverty, ethnic heterogeneity, and high population turnover, contributes to a lowered ability of individuals and communities to control crime, vandalism, and violence. The social vulnerability in health is not a "natural" or predefined condition but occurs because of the unequal social context that surrounds the daily life of the disadvantaged, and often, socially excluded groups. Social exclusion of individuals and groups is a major threat to development, whether to the community social cohesion and economic prosperity or to the individual self-realization through lack of recognition and acceptance, powerlessness, economic vulnerability, ill health, diminished life experiences, and limited life prospects. In contrast, social inclusion is seen to be vital to the material, psychosocial, and political aspects of empowerment that underpin social well-being and equitable health. Successful experiences of cooperation and networking between slum-based organizations, grassroots groups, local and international NGOs, and city government are important mechanisms that can be replicated in urban settings of different low- and middle-income countries. With increasing urbanization, it is imperative to design health programs for the urban poor that take full advantage of the social resources and resourcefulness of their own communities.
Full Text Available The article reveals the question of using of the method of coaching in preparation of the students to the managerial activity in the sphere of preschool education in mountain areas. The necessity of preparation under the modern conditions of social-economic development of mountain areas has been proved. The content of the article generalizes basic contradictions between the necessity and reality. The definition of the main points of the research has been given. The attention is accentuated on the basic principles of management and on the notion “coaching” in the process of management of preschool education in mountain area. Coaching includes partnership, potential revealing, effectiveness. Methodology of coaching is based on the principle that the person naturally is sufficiently talented and owns great potential, which isn’t realized fully. An important condition of this approach is valuable, respectful attitude of the participants of polylogue to one another. Basic theoretical regulations of the coaching approach have been determined. In the context of selection of teching technologies on the basis of coaching approach, the method “reflexive team” has been briefly revealed. It is determined that coaching is a style of management, transformed culture: if the authoritarian style is substituted into coaching, then the hierarchy changes from the support of blaming and ridiculing to the objective evaluation, all-hands activity changes to strategic planning. Coaching approach will allow optimizing the structure of economic activity of a separate preschool educational establishment. The attention is accentuated at the fact, that using coaching with the students at the lessons as a style of management of preschool education, will let future managers of preschool educational establishments to form the skills of behavior in critical situations of mountain area, to enrich their activity with the new means of performing, to develop professional
After a brief review of the concept of health equity and its social and sectoral determinants, some macroeconomic aspects of health expenditure in Latin America are considered. Given the significant contemporary tensions with regard to social rights and the definition of health benefits, three emblematic experiences are analyzed in very different health systems, namely those of Chile, Colombia and Mexico. They cover different aspects, such as the guarantee of health benefits, the reduction of forms of implicit rationing and/or barriers to admission, and also aspects related to the quality of services.
Full Text Available The aim of an enterprise is to increase its value. This growth can be achieved if initiated socially responsible activities improve the value drivers. The company’s specificity, type of its environment and their mutual reactions create conditions conducive to improvement of the driving forces of value by being socially responsible. Bearing this observation in mind we can formulate five strategies of creating value based on social responsibility. These are strategies of perfection, positive selection, surroundings modification, transformation and transposition.
Jandrić-Balen, Marica; Balen, Ivica
During World War I, social and health conditions were difficult in Brod na Savi, as it stationed a large number of troops, and the military hospital was crowded with patients. With so many able-bodied men and breadwinners mobilised, the town's economy verged on the brink of poverty, but people managed to keep starvation at bay. The most common diseases among civilians were tuberculosis, malaria, intestinal infectious diseases, diphtheria, and venereal diseases, and in 1915 cholera broke out that lasted five months. At the end of 1918 "Spanish flu" also hit the town. The number of wounded and sick soldiers occasionally surpassed the hospital's capacity, so they had to be stationed at the local school facilities for a while. Over two thousand people died in the military hospital, which suggests that the total number of patients who went through the hospital had to be very large. Unfortunately, there are no records to show the hospital's mortality rate or disease prevalence. We are currently trying to establish the demographics of the 2000 dead buried at the local cemetery during WWI using the death records we have.
Vera Mikhailovna Alekseeva
Full Text Available Introduction. Tuberculosis is one of the most important medical and social problems in the whole world as well as in Russia and its separate regions. Purpose. The study was aimed at assessment of tuberculosis epidemic situation in the Chechen Republic in the current socio-economic conditions after counterterrorist operations. Materials and methods. The authors analyzed the annual reports of the Ministry of Health of the Chechen Republic for 2010–2015, data of Rosstat, statistical data form for tuberculosis (№ 8 and № 30. Results. The results shown a threefold increase in the main tuberculosis indicators (incidence, prevalence and mortality after counterterrorist operations (1994–1996, and a decrease in these indicators in 2010–2015. The authors have found the cities and rural municipal districts with the most and the least favorable tuberculosis situation. The study results demonstrated an increase in the number of patients with bacillary, with fibrous-cavernous form, as well as patients with tuberculosis in combination with HIV infection. The authors proved the relation between the prevalence of fibrous-cavernous form of tuberculosis and mortality rate. Tuberculosis incidence in children (0–14 years and adolescents (15–17 years decreased in 2010–2015 while the incidence in adolescents remains higher than the incidence in children. Conclusion. Effective antituberculosis work in the Chechen Republic needs to improve the quality of medical examinations, early detection of tuberculosis, timely immunization, and health education.
Zhan, Yuanchao; Buchan, Alison; Chen, Feng
Coliphage N4 is a lytic bacteriophage discovered nearly half a century ago, and it was considered to be a "genetic orphan" until very recently, when several additional N4-like phages were discovered to infect nonenteric bacterial hosts. Interest in this genus of phages is stimulated by their unique genetic features and propagation strategies. To better understand the ecology of N4-like phages, we investigated the diversity and geographic patterns of N4-like phages by examining 56 Chesapeake Bay viral communities, using a PCR-clone library approach targeting a diagnostic N4-like DNA polymerase gene. Many new lineages of N4-like phages were found in the bay, and their genotypes shift from the lower to the upper bay. Interestingly, signature sequences of N4-like phages were recovered only from winter month samples, when water temperatures were below 4°C. An analysis of existing metagenomic libraries from various aquatic environments supports the hypothesis that N4-like phages are most prolific in colder waters. In particular, a high number of N4-like phages were detected in Organic Lake, Antarctica, a cold and hypersaline system. The prevalence of N4-like phages in the cold biosphere suggests these viruses possess yet-to-be-determined mechanisms that facilitate lytic infections under cold conditions. Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Dmitrii Vladimirovich Afanas’ev
Full Text Available The concept of social capital has gained considerable popularity in the social sciences, as well as in practical politics on a national and international scale. Its heuristic potential is confirmed by numerous studies demonstrating the positive impact of the level and types of social capital on a wide range of economic, social and political phenomena, and especially the use of the concept of social capital to study economic growth and development issues. However, there is no universally accepted definition of social capital, and there is no unanimous opinion concerning the ways of measuring it. The paper contains a review of the current status of the theoretical field of the concept; it shows that researchers from different countries are interested in the impact of social capital on economic growth and development at the regional level. Specific comparative studies in different countries and regions strongly support the presence of a correlation that proves social capital is one of the powerful driving forces of development. However, since the majority of studies on the effects of social capital on economic development are concentrated in the developed countries of Western Europe and the USA, it is important to evaluate the potential of this approach in the countries of post-Communist development that have different experience, in particular, in Russia. In this regard, the article points out that there is a clear lack of such studies with regard to Russia’s regions, where there are only occasional fragmentary attempts to study social capital. The aim of the paper is to substantiate on the theoretical basis and to indicate the prerequisites for empirical studies on the effects of social capital of regions on their economic growth and development, especially under the conditions of the general economic and structural crisis
Murray W. Scown
Full Text Available A recent paradigm shift from purely biophysical towards social-ecological assessment of watersheds has been proposed to understand, monitor, and manipulate the myriad interactions between human well-being and the ecosystem services that watersheds provide. However, large-scale, quantitative studies in this endeavour remain limited. We utilised two newly developed ‘big-data’ sets—the Index of Watershed Integrity (IWI and the Human Well-Being Index (HWBI—to explore the social-ecological condition of watersheds throughout the conterminous U.S., and identified environmental and socio-economic influences on watershed integrity and human well-being. Mean county IWI was highly associated with ecoregion, industry-dependence, and state, in a spatially-explicit regression model (R2 = 0.77, 'P' < 0.001, whereas HWBI was not (R2 = 0.31, 'P' < 0.001. HWBI is likely influenced by factors not explored here, such as governance structure and formal and informal organisations and institutions. ‘Win-win’ situations in which both IWI and HWBI were above the 75th percentile were observed in much of Utah, Colorado, and New Hampshire, and lessons from governance that has resulted in desirable outcomes might be learnt from here. Eastern Kentucky and West Virginia, along with large parts of the desert southwest, had intact watersheds but low HWBI, representing areas worthy of further investigation of how ecosystem services might be utilised to improve well-being. The Temperate Prairies and Central USA Plains had widespread areas of low IWI but high HWBI, likely a result of historic exploitation of watershed resources to improve well-being, particularly in farming-dependent counties. The lower Mississippi Valley had low IWI and HWBI, which is likely related to historical (temporal and upstream (spatial impacts on both watershed integrity and well-being. The results emphasise the importance of considering spatial and temporal trade-offs when utilising the
Turner, Niall; Ferguson, Lisa; Hill, Michele; Nesbitt, Tara; O'Callaghan, Eadbhard; O'Mahony, Paul; Clarke, Mary
Understanding social inclusion among at-risk populations will deepen our understanding of their specific needs. This study explored the level of social inclusion among people with psychotic-related conditions using a standardised interview. The Social Inclusion Interview Schedule was used in two research projects. People with psychosis participated in both studies and had been recruited as part of an Irish programme of research on psychotic conditions. Descriptive statistics were used to quantify participants' level of social exclusion. Data from 71 participants were available, 38 in one cohort and 33 in the other. The smaller cohort had a shorter mean duration of illness. Participants' mean age was 40. The majority lived in the community and were satisfied with their living arrangements. In each cohort, the same two areas of community integration emerged as problematic - having something productive to do and being close to someone in the community. There was a higher level of perceived stigma among the cohort with the longer duration of illness. While evidence of social inclusion was found among participants, there were areas of concern particularly with regard to integration into work and social connectedness.
A. M. Kamyshnyi
Full Text Available Stress-induced immune disregulation is a risk factor of autoimmune and inflammatory diseases, but, so far, the mechanisms for this effect are not fully known. Expression levels of specific mRNAs were assessed in gut-associated lymphoid tissue (GALT from Wistar rats subjected to chronic social stress (CSS. Gene expression was evaluated for NR3C1, Adrβ2, as well as IL-1β, IL-17α pro-inflammatory cytokines, and Nlrp, an inflammasome gene. Under the CSS conditions, we have shown altered distribution of RORγt +, FoxP3+, LMP2+, XBP1+ lymphocytes in GALT.The experiments were carried out with female Wistar rats aged 5–6 months. Specific mRNA expression for the target genes was determined by means of real-time PCR performed in a CFX96™ thermocycler («BioRadLaboratories, Inc»,USA. Relative levels of a target gene expression were quantified by the ΔΔCt method, being compared with rat GAPDH reference gene expression. Statistical analysis was performed with available «BioRad СFX Manager 3.1» software. Specific monoclonal rat antibodes were used for detection of immunopositive lymphocytes by means of indirect immunofluorescence technique.CSS development leads to decreased levels of mRNA expression for Nr3c1 and Adrβ2-genes in the GALT cells, being accompanied with unidirectional changes, i.e., increased transcription of pro-inflammatory cytokine mRNAs (IL-1β, IL-17α and Nlrp3-inflammasome genes. These changes are accompanied by decreased FoxP3+/RORγt + cell ratio and predominant Th17 differentiation accompanied by suppressor failure. In addition, CSS development was characterized by unidirectional tendency for increasing total number of LMP2+ lymphocytes and reduced ХВР1+ cell population density in lymphoid structures of rat ileum.The events observed in GALT cell populations under CSS conditions are opposing classical paradigm of the stress response. The CSS-associated effects do not promote immunosuppression, however, are able to cause
Focussing on individuals and institutions, the economic and social condition of the people of Fort Cochin between 1781 and 1830 has been studied. This study of the Dutch East India Company's (VOC) establishment on the south west coast of India provides a detailed research into the functioning of the
Naguib, M.; Floercke, C.; Oers, van K.
Environmental conditions during early development play a crucial role in shaping an organism's phenotype. To test how social group size affects stress response and behavioral characteristics, we used great tits (Parus major) from selection lines for exploratory behavior, a proxy for an avian
Cronin, Adam L
Social animals can use both social and private information to guide decision making. While social information can be relatively economical to acquire, it can lead to maladaptive information cascades if attention to environmental cues is supplanted by unconditional copying. Ants frequently employ pheromone trails, a form of social information, to guide collective processes, and this can include consensus decisions made when choosing a place to live. In this study, I examine how house-hunting ants balance social and private information when these information sources conflict to different degrees. Social information, in the form of pre-established pheromone trails, strongly influenced the decision process in choices between equivalent nests, and lead to a reduced relocation time. When trails lead to non-preferred types of nest, however, social information had less influence when this preference was weak and no influence when the preference was strong. These results suggest that social information is vetted against private information during the house-hunting process in this species. Private information is favoured in cases of conflict and this may help insure colonies against costly wrong decisions.
Adam L Cronin
Full Text Available Social animals can use both social and private information to guide decision making. While social information can be relatively economical to acquire, it can lead to maladaptive information cascades if attention to environmental cues is supplanted by unconditional copying. Ants frequently employ pheromone trails, a form of social information, to guide collective processes, and this can include consensus decisions made when choosing a place to live. In this study, I examine how house-hunting ants balance social and private information when these information sources conflict to different degrees. Social information, in the form of pre-established pheromone trails, strongly influenced the decision process in choices between equivalent nests, and lead to a reduced relocation time. When trails lead to non-preferred types of nest, however, social information had less influence when this preference was weak and no influence when the preference was strong. These results suggest that social information is vetted against private information during the house-hunting process in this species. Private information is favoured in cases of conflict and this may help insure colonies against costly wrong decisions.
Ledford, Jennifer R.; King, Seth; Harbin, Emilee R.; Zimmerman, Kathleen N.
Social skills interventions designed to increase pro-social interactions for individuals with autism spectrum disorders are critical, but the relative effectiveness of these interventions is not well understood. More than 250 single-case design studies in 113 articles were reviewed and described in terms of participants, settings, arrangements,…
Sattoe, J.N.T.; Hilberink, S.R.; Staa, A. van; Bal, R.
Purpose: Typical childhood and adolescent development and acquiring self-management skills are crucial for a satisfying adult life and autonomy in social participation. The aims of this study were to identify patterns of autonomy in social participation and to explore differences between these
Full Text Available Social capital plays an important role in the profit formation of business entity in the context of the implementation of integrated reporting. The purpose of the research is to examine the problematic aspects of accounting and analytical support of social capital in the context of sustainable development which involves the study of «social capital» and «social networks» concepts, the definition of the functions of social capital in the structure of company’s capital, the disclosure of social capital assessment peculiarities. To achieve the goal of article the author uses the methods of induction, deduction, analogy, comparison, the systematic approach to the assessment of economic phenomena, the historical method, the data grouping method, and the process approach. The accounting tasks in the context of sustainable socio-economic and environmental development are identified. The essence of «social capital» concept, its importance in the formation of an integrated enterprise reporting, and its elements are characterized. The problematic issues of social capital assessment are analyzed and the possible solutions are discussed. The necessity of introduction of new facilities and new accounting approaches to the organization of accounting are proved.
Burton, Tim; Hoogenboom, M. O.; Armstrong, J. D.; Groothuis, T. G. G.; Metcalfe, N. B.; Williams, Tony
1. Social status can vary considerably among individuals and has significant implications for performance. In addition to a genetic component, social status may be influenced by environmental factors including maternal effects such as prenatal hormone exposure. Maternal effects on traits determining
... 3206-AM50 Prevailing Rate Systems; Redefinition of the Austin, TX and Waco, TX, Appropriated Fund... the Federal Prevailing Rate Advisory Committee to best match the counties proposed for redefinition to... Prevailing Rate Advisory Committee (FPRAC), the national labor-management committee responsible for advising...
... 3206-AM70 Prevailing Rate Systems; Redefinition of the St. Louis, MO; Southern Missouri; Cleveland, OH... Cleveland wage area. These changes are based on recent consensus recommendations of the Federal Prevailing... proposing the changes described below. The Federal Prevailing Rate Advisory Committee (FPRAC), the national...
...-AM21 Prevailing Rate Systems; Redefinition of the Chicago, IL; Fort Wayne-Marion, IN; Indianapolis, IN... wage area. These changes are based on recent consensus recommendations of the Federal Prevailing Rate... below. The Federal Prevailing Rate Advisory Committee (FPRAC), the national labor-management committee...
...)(v)(E) and (F). If the prevailing wage rate is too low, available U.S. workers may be dissuaded from... Docket No. USCIS-2010-0006] RIN 1615-ZA98 Prevailing Wage Rates for Construction Occupations on Guam for... the public on the system that the Governor of Guam is using to determine prevailing wage rates for...
... Staying Safe Videos for Educators Search English Español Social Phobia KidsHealth / For Teens / Social Phobia What's in ... an anxiety condition called social phobia. What Is Social Phobia? Social phobia (also called social anxiety ) is ...
Full Text Available Purpose: to develop fundamental basis of science based healthcare management in social and economic instability. Public health state (1998-2008, selected region was characterized by cardiovascular health parameters (Code IX, ICD-10. Systematic review was performed according to PRISMA guidelines. Dynamic characteristics of major cardiovascular diseases in social and economic instability considered as a cause of a population system destabilization were reconstructed. Conclusion. Fundamentals of science based healthcare management in social and economic instability include long- and short-term prognosis of public health characteristics as the result of multifactor external influences on cardiovascular diseases prevalence.
Amadeo Ramos Carranza
Full Text Available RESUMEN La arquitectura del siglo XX, con sus teorías, sus propuestas, proyectos y realidades, ha sido la que nos ha enseñado a observar con renovado interés las infraestructuras y a considerarlas como una forma de pensar nuestra disciplina. En cada nueva situación la arquitectura ha señalado y diseñado los lugares de las infraestructuras; se ha modificado el contexto y se han vuelto a generar nuevas situaciones. Se incide directamente en la organización de las estructuras urbanas y territoriales, en la movilidad interior de las ciudades y sobre todo, en la manera que las personas acaban relacionándose. Aalto nos ofrece un claro ejemplo a través de dos infraestructuras aparentemente idénticas con resultados muy diferentes; un punto de vista desde el que pueden observarse otras propuestas de infraestructuras urbanas surgidas a partir de la segunda mitad del siglo XX, o las nuevas tendencias de movilidad del espacio en un mundo globalizado con menor presencia colectiva y social frente al carácter individual de cada persona. SUMMARY 20th century architecture, with its theories, its proposals, projects and realities have taught us to look at infrastructure with renewed interest and to consider them as another form in which to think about architecture. In each new situation architecture has pointed to and designed the locations for the infrastructures; the context has been modified and new situations have been generated. It is possible to extract from them their social component with a direct impact on the organisation of the urban and territorial structures, in the interior mobility of the city and above all, in the way that people relate to each other. Aalto offers us a clear example through two apparently identical structures with very different results; a point of view from which other proposals of urban infrastructures can be observed and which have emerged in the second half of the 20th century, or new trends of space mobility in a
Jan Rottenbacher de Rojas
Full Text Available The influence of right-wing political conservatism on support for democracy and the criminalization of social protest is analyzed in a sample of university students from the city of Lima (N = 201. As indicators of the right-wing political conservatism, measures of right-wing authoritarianism (RWA, social dominance orientation (SDO and right-wing political orientation were used. Two path diagrams were proposed: the second diagram showed a proper degree of fit and proposes a positive covariance between RWA, SDO and right-wing political orientation. The diagram also suggests that RWA, SDO and right-wing political orientation exert a direct influence on the criminalization of social protest, while SDO and RWA exert an indirect influence on support for democracy. Finally, support for democracy present an inverse correlation with the criminalization of social protest.
Scior, Katrina; Furnham, Adrian
Evidence on mental illness stigma abounds yet little is known about public perceptions of intellectual disability. This study examined causal beliefs about intellectual disability and schizophrenia and how these relate to awareness of the condition and social distance. UK lay people aged 16+(N=1752), in response to vignettes depicting intellectual disability and schizophrenia, noted their interpretation of the difficulties, and rated their agreement with 22 causal and four social distance items. They were most likely to endorse environmental causes for intellectual disability, and biomedical factors, trauma and early disadvantage for schizophrenia. Accurate identification of both vignettes was associated with stronger endorsement of biomedical causes, alongside weaker endorsement of adversity, environmental and supernatural causes. Biomedical causal beliefs and social distance were negatively correlated for intellectual disability, but not for schizophrenia. Causal beliefs mediated the relationship between identification of the condition and social distance for both conditions. While all four types of causal beliefs acted as mediators for intellectual disability, for schizophrenia only supernatural causal beliefs did. Educating the public and promoting certain causal beliefs may be of benefit in tackling intellectual disability stigma, but for schizophrenia, other than tackling supernatural attributions, may be of little benefit in reducing stigma. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
García-Pardo, M P; Blanco-Gandía, M C; Valiente-Lluch, M; Rodríguez-Arias, M; Miñarro, J; Aguilar, M A
Previous studies have demonstrated that social defeat stress increases the rewarding effects of psychostimulant drugs such as cocaine and amphetamine. In the present study we evaluated the long-term effects of repeated social defeat (RSD) on the rewarding effects of ±3,4-methylenedioxymethamphetamine (MDMA) hydrochloride in the conditioned place preference (CPP) paradigm. Adolescent and young adult mice were exposed to four episodes of social defeat (on PND 29-40 and PND 47-56, respectively) and were conditioned three weeks later with 1.25 or 10mg/kg i.p. of MDMA (experiment 1). The long-term effects of RSD on anxiety, social behavior and cognitive processes were also evaluated in adult mice (experiment 2). RSD during adolescence enhanced vulnerability to priming-induced reinstatement in animals conditioned with 1.25mg/kg of MDMA and increased the duration of the CPP induced by the 10mg/kg of MDMA. The latter effect was also observed after RSD in young adult mice, as well as an increase in anxiety-like behavior, an alteration in social interaction (reduction in attack and increase in avoidance/flee and defensive/submissive behaviors) and an impairment of maze learning. These results support the idea that RSD stress increases the rewarding effects of MDMA and induces long-term alterations in anxiety, learning and social behavior in adult mice. Thus, exposure to stress may increase the vulnerability of individuals to developing MDMA dependence, which is a factor to be taken into account in relation to the prevention and treatment of this disorder. Copyright © 2015 Elsevier Inc. All rights reserved.
Peng, Xuefeng; Luo, Jiebo; Glenn, Catherine; Zhan, Jingyao; Liu, Yuhan
Sleep condition is closely related to an individual's health. Poor sleep conditions such as sleep disorder and sleep deprivation affect one's daily performance, and may also cause many chronic diseases. Many efforts have been devoted to monitoring people's sleep conditions. However, traditional methodologies require sophisticated equipment and consume a significant amount of time. In this paper, we attempt to develop a novel way to predict individual's sleep condition via scrutinizing facial ...
Full Text Available The thesis that companies’ activities for introduction of corporate social responsibility stimulates the speed of to the processes of the technical upgrade, modernization of company’s activity and increase of its profitability is proved within the article. Those Ukrainian companies, which have high index of activities transparency, are also the most profitable. However, we can’t observe any significant increment of number of companies joining the Global agreement. One of the explanations we could name is the unproved idea supported by some politicians and economists about a shadow (‘black’ market that allegedly allows creating workplaces and taking off social tension in society on the certain stage. Insignificant values of index of citizens’ trust to activity of industries holds on the development socially of responsible business. Trust considered as a part of the general social capital. The Government of Ukraine must support initiative of companies to introduce social responsibility of business, as many European governments do it. It is also important to inform society of advantages of CSR.
Abbas, Farhat; Rehman, Iqra; Adrees, Muhammad; Ibrahim, Muhammad; Saleem, Farhan; Ali, Shafaqat; Rizwan, Muhammad; Salik, Muhammad Raza
This study examines the variability and change in the patterns of climatic extremes experienced in Indus-Delta of Sindh province of Pakistan, comprising regions of Karachi, Badin, Mohenjodaro, and Rohri. The homogenized daily minimum and maximum temperature and precipitation data for a 36-year period were used to calculate 13 and 11 indices of temperature and precipitation extremes with the help of RClimDex, a program written in the statistical software package R. A non-parametric Mann-Kendall test and Sen's slope estimates were used to determine the statistical significance and magnitude of the calculated trend. Temperatures of summer days and tropical nights increased in the region with overall significant warming trends for monthly maximum temperature as well as for warm days and nights reflecting dry conditions in the study area. The warm extremes and nighttime temperature indices showed greater trends than cold extremes and daytime indices depicting an overall warming trends in the Delta. Historic decrease in the acreage of major crops and over 33% decrease in agriculture credit for Sindh are the indicators of adverse impacts of warmer and drier weather on Sindh agriculture. Trends reported for Karachi and Badin are expected to decrease rice cultivation, hatching of fisheries, and mangroves forest surrounding these cities. Increase in the prevailing temperature trends will lead to increasingly hotter and drier summers resulting to constraints on cotton, wheat, and rice yield in Rohri and Mohenjodaro areas due to increased crop water requirements that may be met with additional groundwater pumping; nonetheless, the depleted groundwater resources would have a direct impact on the region's economy.
Bruno Sciberras de Carvalho
Full Text Available This article critically analyzes new sociological approaches to the rational choice theory which - beyond examining political or economic practices - link the notion of instrumental rationality to social issues and themes. The article begins by highlighting the issue of trust, indicating the functionality of certain social arrangements in collective problem-solving. The paper goes on to demonstrate that problems emerge with the theory when it attempts to explain the feasibility of social norms in impersonal, comprehensive contexts. Thus, the fundamental point that appears to be missing from rational choice theory is the perception that individual decisions and instrumental conduct itself incorporate dispositions that in a sense are beyond the actors' control.
О. О. Пащенко
Full Text Available The scientific looks of О. V. Naden in relation to the problem of social conditionality of criminal legislation are investigated. Factors that are offered to take into account a legislator during setting of criminal responsibility for certain kind’s publicly dangerous behavior are considered. The realizable a scientist attempt of decision of problem is analyzed at general level by means of determination of limits of sphere of the criminal and legal adjusting.
Peat, George; Smith, Joanna; Rodriguez, Alison
EBN engages readers through a range of Online social media activities to debate issues important to nurses and nursing. EBN Opinion papers highlight and expand on these debates. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Workplace relations like any social relation first and foremost have a moral dimension. Thus, if vocational education sees one of its major goals in helping apprentices to deal with moral issues, one of the core objectives in vocational education is the support of the apprentice's development of moral judgement competence. Since Lawrence Kohlberg…
Fokkema, Dirk S.; Koolhaas, Jaap M.
The naturally occurring tendency to compete with other rats for territorial space has been used to study individual behavior characteristics and blood pressure reactivity to social stimuli in adult male TMD-S3 rats. The competitive characteristics of the individual rats are consistent in two
A recent paradigm shift from purely biophysical towards social-ecological assessment of watersheds has been proposed to understand, monitor, and manipulate the myriad interactions between human well-being and the ecosystem services that watersheds provide. However, large-scale, q...
Marková, Petra; Beňo, Rastislav; Hatiar, Karol
Gradually increasing pressure on companies to start to behave socially responsible is a response to social, environmental and economic requirements. The society faces a period of changes that have occurred since the beginning of the crisis and revealing weaknesses in the economy. We become witnesses of rapid changes and challenges posed by globalization, lack of resources, demographic structure and innovation. Objective necessity becomes a corporate social responsibility (CSR) already at the companies’ level, which is supported by the approach of the EU institutions and the Slovak Republic. One of the possible appliance through which we can contribute to the sustainability of CSR are sustainable ergonomic programs. When we want to talk about sustainable ergonomic program is important to focus on three key areas. The first area is the Impact of technic and technology to employees at work, the second area is the Importance and impact of socially responsible HR in ergonomics and last area is the Creation of the work environment in relation to environmental sustainability. Ergonomic programs sustainability requires to apply appropriate methods for evaluation of their cost benefit and health effect.
Washburn, Dustin; Wilson, Gillian; Roes, Meighen; Rnic, Katerina; Harkness, Kate Leslie
Social anxiety disorder is characterized by marked interpersonal impairment, particularly when presenting with comorbid major depression. However, the foundational social-cognitive skills that underlie interpersonal impairment in comorbid and non-comorbid manifestations of SAD has to date received very little empirical investigation. In a sample of 119 young adults, the current study examined differences in theory of mind (ToM), defined as the ability to decode and reason about others' mental states, across four groups: (a) non-comorbid SAD; (b) non-comorbid Lifetime MDD; (c) comorbid SAD and Lifetime MDD; and (d) healthy control. The non-comorbid SAD group was significantly less accurate at decoding mental states than the non-comorbid MDD and control groups. Further, both the comorbid and non-comorbid SAD groups made significantly more 'excessive' ToM reasoning errors than the non-comorbid MDD group, suggesting a pattern of over-mentalizing. Findings are discussed in terms of their implications for understanding the social cognitive foundations of social anxiety. Copyright © 2015 Elsevier Ltd. All rights reserved.
Full Text Available Recruitment strategy and policy are significantly affected by both the internal conditions of the enterprise and the external environment. It is important to anticipate and react to changes in the labor market in a timely manner, to eliminate potential threats and take advantage of opportunities to continuous staffing of current and future needs of the enterprise. The role of managers in deciding on possible techniques for recruiting employees is to respect the principles of sustainability both economically and socially. Due to the use of information technology, this trend is easier to apply in practice, as enterprises can present themselves and get information about potential job seekers. The success of the recruitment process is increasing if public awareness about the employer is positive. Designing the survey methodology was based on the axiom that traditional ways of recruiting employees are being replaced by techniques using the Internet and social networks. The aim of the paper is to present the views of domestic and foreign experts on the recruitment of employees using social networks. We compare the theoretical knowledge with the results of social networking research in SMEs in Slovakia and especially their use in the process of recruiting employees. A total of 324 enterprises with domestic and foreign capital share participated in the sociological questionnaire. The results have shown that enterprises with foreign capital share are more progressive in using the Internet to offer jobs and in gaining information on jobseekers through social networks.
Salmon, Stefanie J.; De Vet, Emely; Adriaanse, Marieke A.; Fennis, Bob M.; Veltkamp, Martijn; De Ridder, Denise T. D.
Under low self-control conditions, people often favor tempting but unhealthy food products. Instead of fighting against low self-control to reduce unhealthy food choices, we aim to demonstrate in a field study that heuristic decision tendencies can be exploited under these conditions. To do so a
Salmon, S.J.; Vet, de E.; Adriaanse, M.A.; Fennis, B.M.; Veltkamp, M.; Ridder, de D.T.D.
Under low self-control conditions, people often favor tempting but unhealthy food products. Instead of fighting against low self-control to reduce unhealthy food choices, we aim to demonstrate in a field study that heuristic decision tendencies can be exploited under these conditions. To do so a
Social barriers in wind power implementation in The Netherlands: Perceptions of wind power entrepreneurs and local civil servants of institutional and social conditions in realizing wind power projects
Agterbosch, Susanne; Glasbergen, Pieter; Vermeulen, Walter J.V.
The primary social factors for the implementation of wind energy projects in a liberalized market are entrepreneurs willing to invest. Understanding conditions that trigger entrepreneurs to invest in these projects, and understanding conditions that determine the chance of success for entrepreneurs to implement and exploit their projects, is vital for setting up effective policies to stimulate wind electricity generation. This paper analyses the way in which wind power entrepreneurs and local civil servants experience social and institutional conditions in the operational process of realizing wind power projects, and their perceptions of policy implications. A groups support system in an electronic board room was used to analyze the perceptions. From the analysis it was concluded that wind power entrepreneurs and civil servants share the opinion that the institutionally embedded power position of local politicians, and the sensitiveness of the local political debate for the popular opinion are most critical for project realization. With regard to the proposed solutions, both groups differ in their approach. Entrepreneurs stress procedural solutions, such as limiting the possibilities to appeal, reducing the complexity of the formal authorization trajectory and using a top down planning approach. Civil servants stress more strategic solutions, such as providing more public information on the necessity of wind power for local politicians and citizens, and community involvement in planning processes. Finally, the analysis explains that steering strategies that have been developed at the national level to solve the planning problems at the operational level do not address the right problems. (author)
Zernig, Gerald; Pinheiro, Barbara S
Impaired social interaction is a hallmark symptom of many psychiatric disorders. In substance use disorders, impaired social interaction is triply harmful (a) because addicts increasingly prefer the drug of abuse to the natural reward of drug-free social interaction, thus worsening the progression of the disease by increasing their drug consumption, (b) because treatment adherence and, consequently, treatment success itself depends on the ability of the recovering addict to maintain social interaction and adhere to treatment, and (c) because socially interacting with an individual suffering from a substance use disorder may be harmful for others. Helping the addict reorient his/her behavior away from the drug of abuse toward social interaction would therefore be of considerable therapeutic benefit. This article reviews our work on the neural basis of such a reorientation from cocaine, as a prototypical drug of abuse, toward dyadic (i.e. one-to-one) social interaction and compares our findings with the effects of other potentially beneficial interventions, that is, environmental enrichment or paired housing, on the activation of the accumbens and other brain regions involved in behavior motivated by drugs of abuse or nondrug stimuli. Our experimental models are based on the conditioned place preference paradigm. As the therapeutically most promising finding, only four 15 min episodes of dyadic social interaction were able to inhibit both the subsequent reacquisition/re-expression of preference for cocaine and the neural activation associated with this behavior, that is, an increase in the expression of the immediate early gene Early Growth Response protein 1 (EGR1, Zif268) in the nucleus accumbens, basolateral and central amygdala, and the ventral tegmental area. The time spent in the cocaine-associated conditioning compartment was correlated with the density of EGR1-activated neurons not only in the medial core (AcbCm) and medial shell (AcbShm) of the nucleus
Rosenberg, Shawn W.
At the beginning of the 21st century, the field of political psychology; like the social sciences more generally, is being challenged. New theoretical direction is being demanded from within and a greater epistemological sophistication and ethical relevance is being demanded from without. In response, direction for a reconstructed political psychology is offered here. To begin, a theoretical framework for a truly integrative political psychology is sketched. This is done in light of the appar...
Herberholz, Jens; Swierzbinski, Matthew E; Birke, Juliane M
Like most social animals, crayfish readily form dominance relationships and linear social hierarchies when competing for limited resources. Competition often entails dyadic aggressive interactions, from which one animal emerges as the dominant and one as the subordinate. Once dominance relationships are formed, they typically remain stable for extended periods of time; thus, access to future resources is divided unequally among conspecifics. We previously showed that firmly established dominance relationships in juvenile crayfish can be disrupted by briefly adding a larger conspecific to the original pair. This finding suggested that the stability of social relationships in crayfish was highly context-dependent and more transient than previously assumed. We now report results that further identify the mechanisms underlying the destabilization of crayfish dominance relationships. We found that rank orders remained stable when conspecifics of smaller or equal size were added to the original pair, suggesting that both dominant and subordinate must be defeated by a larger crayfish in order to destabilize dominance relationships. We also found that dominance relationships remained stable when both members of the original pair were defeated by larger conspecifics in the absence of their original opponent. This showed that dominance relationships are not destabilized unless both animals experience defeat together. Lastly, we found that dominance relationships of pairs were successfully disrupted by larger intruders, although with reduced magnitude, after all chemical cues associated with earlier agonistic experiences were eliminated. These findings provide important new insights into the contextual features that regulate the stability of social dominance relationships in crayfish and probably in other species as well. © 2016 Marine Biological Laboratory.
... Department to ``promulgate new rules concerning the calculation of the prevailing wage rate in the H-2B... wage methodology set forth in this Rule applies only to wages paid for work performed on or after...: Notice. SUMMARY: On January 19, 2011, the Department of Labor (Department) published a final rule, Wage...
... Building, 1900 E Street, NW., Washington, DC. The Federal Prevailing Rate Advisory Committee is composed of... considered and would disrupt substantially the disposition of its business. Therefore, these caucuses will be... 5H27, 1900 E Street, NW., Washington, DC 20415, (202) 606-9400. U.S. Office of Personnel Management...
... of Personnel Management Building, 1900 E Street NW., Washington, DC. The Federal Prevailing Rate... the matters being considered and would disrupt substantially the disposition of its business... Advisory Committee, Room 5H27, 1900 E Street NW., Washington, DC 20415, (202) 606-9400. U.S. Office of...
..., 1900 E Street, NW., Washington, DC. The Federal Prevailing Rate Advisory Committee is composed of a... disrupt substantially the disposition of its business. Therefore, these caucuses will be closed to the... 5H27, 1900 E Street, NW., Washington, DC 20415, (202) 606-9400. U.S. Office of Personnel Management...
... Personnel Management Building, 1900 E Street NW., Washington, DC. The Federal Prevailing Rate Advisory... considered and would disrupt substantially the disposition of its business. Therefore, these caucuses will be... 5H27, 1900 E Street NW., Washington, DC 20415, (202) 606-9400. U.S. Office of Personnel Management...
... 5A06A, U.S. Office of Personnel Management Building, 1900 E Street NW., Washington, DC. The Federal... the matters being considered and would disrupt substantially the disposition of its business... Management, Federal Prevailing Rate Advisory Committee, Room 5H27, 1900 E Street NW., Washington, DC 20415...
Bilginsoy, Cihan; Philips, Peter
Examines effects of prevailing wage laws on school construction costs, using final cost data from six British Columbia school districts. When controlling for factors such as construction business cycle, number of competitors, and school type, there was no significant unit cost change following the Skill Development and Fair Wage Policy Act.…
J. Carlos Domínguez
Full Text Available Resumen: Este trabajo presenta un análisis comparativo de dos movimientos sociales en Latinoamérica. El primero es el movimiento de oposición a la privatización de los servicios de agua potable y alcantarillado en Cochabamba, Bolivia, en el año 2000; y el segundo es el movimiento en contra del proyecto para un nuevo aeropuerto en la Ciudad de México (2001-2002. Ambos casos de estudio ilustran la manera como el estudio de los discursos colectivos y los marcos de acción colectiva pueden servir para mejorar nuestro conocimiento de movimientos sociales que surgen en el contexto de grandes proyectos de infraestructura. El trabajo argumenta que un factor determinante en el desarrollo y tiempo de vida de un movimiento social es la medida en que distintas variables contextuales y organizacionales facilitan o impiden la relación dialógica entre los discursos colectivos y otros procesos de formación de identidad a nivel microsociológico.
Debeffe, Lucie; Poissant, Jocelyn; McLoughlin, Philip D
Costs associated with reproduction are widely known to play a role in the evolution of reproductive tactics with consequences to population and eco-evolutionary dynamics. Evaluating these costs as they pertain to species in the wild remains an important goal of evolutionary ecology. Individual heterogeneity, including differences in individual quality (i.e., among-individual differences in traits associated with survival and reproduction) or state, and variation in environmental and social conditions can modulate the costs of reproduction; however, few studies have considered effects of these factors simultaneously. Taking advantage of a detailed, long-term dataset for a population of feral horses (Sable Island, Nova Scotia, Canada), we address the question of how intrinsic (quality, age), environmental (winter severity, location), and social conditions (group size, composition, sex ratio, density) influence the costs of reproduction on subsequent reproduction. Individual quality was measured using a multivariate analysis on a combination of four static and dynamic traits expected to depict heterogeneity in individual performance. Female quality and age interacted with reproductive status of the previous year to determine current reproductive effort, while no effect of social or environmental covariates was found. High-quality females showed higher probabilities of giving birth and weaning their foal regardless of their reproductive status the previous year, while those of lower quality showed lower probabilities of producing foals in successive years. Middle-aged (prime) females had the highest probability of giving birth when they had not reproduced the year before, but no such relationship with age was found among females that had reproduced the previous year, indicating that prime-aged females bear higher costs of reproduction. We show that individual quality and age were key factors modulating the costs of reproduction in a capital breeder but that
Keim-Malpass, Jessica; Spears Johnson, Chaya R; Quandt, Sara A; Arcury, Thomas A
In the USA, migrant farmworkers are a vulnerable group due to their low socioeconomic status, risk of occupational exposures and injury, lack of social mobility, lack of adequate access to health services and dependency on employer for provided housing. Previous reports have documented migrant farmworker housing conditions to be variable, but poor overall. This paper explores the perceptions of housing conditions among migrant farmworkers in rural North Carolina, and develops an understanding of potential impacts of their housing on health and safety. This study used qualitative descriptive data and directed content analysis to analyse semi-structured interviews and photographs that were data elements of a larger community-based participatory research study designed to document housing quality and health among North Carolina farmworkers. Many of the study participants described poor housing conditions that were reflected in the photographic analysis of the houses and camps. Specific problems described by the participants include exposure to pesticides, safety issues, pests, water supply and air quality, temperature and moisture. This study describes migrant farmworkers' perceptions of housing quality and numerous potential impacts on health and safety. Research, social policy and practice-based implications derived from this research could serve to improve the health status of these individuals and their families. This study suggests there is much room for sustained advocacy and action, given that many of the farmworkers' descriptions and photographs depicted housing conditions below accepted standards of living. Access to adequate and safe employer-provided housing for migrant farmworkers should be considered a basic human right.
Sahar Mirghobad Khodarahmi
Full Text Available This paper presents a social work study on relationship between thinking style and self-esteem as well as socio-economic conditions among university students. The study selects 512 students from Islamic Azad University of Najafabad in province of Esfahan, Iran and distributes a questionnaire, which measures creativity and self-esteem. We also collect students’ socio-economic conditions and analyze the information. The results of our survey disclose that thinking style and self-esteem have overlap with each other. In addition, students with better socio-economic conditions are more creative and use complex style of thinking. The study also provides some guidelines for practically implementing the results of our survey among other students.
Fors, Stefan; Lennartsson, Carin; Lundberg, Olle
The aim of the present study was to investigate the impact of childhood living conditions, marital status, and social class in adulthood on the risk of mortality during mid-life. Two questions were addressed: Is there an effect of childhood living conditions on mortality risk during mid-life and if so, is the effect mediated or modified by social class and/or marital status in adulthood? A nationally representative, Swedish, level of living survey from 1968 was used as baseline. The study included those aged 25-69 at baseline (n = 4082). Social conditions in childhood and adulthood were assessed using self-reports. These individuals were then followed for 39 years using registry data on mortality. The results showed associations between childhood living conditions, marital status, social class in adulthood and mortality during mid life. Social class and familial conditions during childhood as well as marital status and social class in adulthood all contributed to the risk of mortality during mid-life. Individuals whose father's were manual workers, who grew up in broken homes, who were unmarried, and/or were manual workers in adulthood had an increased risk of mortality during mid life. The effects of childhood conditions were, in part, both mediated and modified by social class in adulthood. The findings of this study suggest that there are structural, social conditions experienced at different stages of the life course that affect the risk of mortality during mid-life.
Chanda, Sandip; De, Abhinandan
A social welfare optimization technique has been proposed in this paper with a developed state space based model and bifurcation analysis to offer substantial stability margin even in most inadvertent states of power system networks. The restoration of the power market dynamic price equilibrium has been negotiated in this paper, by forming Jacobian of the sensitivity matrix to regulate the state variables for the standardization of the quality of solution in worst possible contingencies of the network and even with co-option of intermittent renewable energy sources. The model has been tested in IEEE 30 bus system and illustrious particle swarm optimization has assisted the fusion of the proposed model and methodology.
Bauer, Heide-Katharina; Heller, Martin; Fink, Matthias; Maresch, Daniela; Gartner, Johannes; Gassner, Ulrich M; Al-Nawas, Bilal
The beginnings of three-dimensional (3D) printing and bioprinting can be traced to as early as 1984. From printing inorganic models for the generation of biologic scaffolds, additive manufacturing (AM) developed to the direct printing of organic materials, including specialized tissues, proteins, and cells. In recent years, these technologies have gained significantly in relevance, and there have been several innovations, especially in the field of regenerative medicine. It is becoming increasingly important to consider the economic and social aspects of AM, particularly in education and information of medical human resources, society, and politics, as well as for the establishment of homogenous, globally adapted legal regulations.
Gayatri, S.; Sumarjono, D.; Satmoko, S.
The aim of the study was to explore the potential of social capital and growing income of red guava farmers in Tambahrejo Village, Pageruyung District, Kendal Regency. Interview and observation were used for data collection. Set of Questionnaire was developed to answer research’ goal. All member of farmer group I ACC (Kelompok Tani Makmur I ACC) were chosen as respondents in this research. Data were analyzed using multiple regressions. The result shows that there was significant relationship between social capital in community and the income of the red guava farmers. Farmer’ group was found as a media to improve farmers’ knowledge and networking. Farmers group facilitated farmers to market red guava product. Moreover, wife of the farmers established women group or KWT (Kelompok Wanita Tani). The result found that KWT contributed to improve family’s income. KWT also promote activities to help product’s diversification of red guava. Both farmer group and KWT provided activities such as saving and loans, it means there was trust among member of farmer group.
The study of epistemic thinking focuses on how people understand and coordinate objective and subjective aspects of knowing and make sense of multiple and discrepant knowledge claims. Typically described in terms of normative development, cross-cultural studies show differences in epistemic development and characteristics of epistemic thinking. This study focuses on within-culture variations of epistemic thinking, with the assumption that social change will produce changes in development. Arab society in Israel has undergone notable change over the last half century. In this cross-sectional research design, cross-generational comparison and rural-urban comparison were used as proxies for longitudinal social change. Three generations of Muslim Arab women in a village in Israel (20 adolescents, 20 mothers and 20 grandmothers) and 20 Muslim Arab adolescents from a large, mixed city in the same region responded to six dilemmas invoking epistemic thinking. Village adolescents were more subjectivist than their mothers and grandmothers. Sociodemographic characteristics representing greater exposure to diverse people and ideas accounted for generational differences. Both urban and rural adolescents tended towards subjectivist perspectives, and they did not differ. Parents' education levels emerged as the sociodemographic variables most consistently related to epistemic thinking. Epistemic thinking mediated the relationship between generation and gender role/cross-sex relation values. © 2014 International Union of Psychological Science.
Viktor Nikolaevich Pustovoytov
Full Text Available Experience in the sphere of independent cognitive activity - cognitive competence - and the experience of communication and awareness of the significance of its activity in some field - social-communicative competence are important quality of modern man. Article considers the problem of forming the informative and social-communicative competences of students. It is shown that these competencies are key personal meta- and cross-competencies. Psycho-pedagogical strategies supporting their formation can be designed and implemented as a unified process. Effective medium formation of experience in the field of self-regulated learning, communicative experience and awareness of the personal importance of cognitive activity is learning academic subjects, and the condition and means - interactive forms of learning. The implementation of group-differentiated form of organization of students is analyzed in this context. Results of the study outlined in this article, have contributed to the problems of implementing competence-based approach to learning.
Mario Vianna Vettore
Full Text Available OBJECTIVE: To assess the relationship between housing conditions and low birthweight and preterm low birthweight among low-income women. METHODS: A case-control study was conducted with post-partum women living in the city of Rio de Janeiro, Southeast Brazil, in 2003-2005. Two groups of cases, low birthweight (n=96 and preterm low birthweight infants (n=68, were compared against normal weight term controls (n=393. Housing conditions were categorized into three levels: adequate, inadequate, and highly inadequate. Covariates included sociodemographic and anthropometric characteristics, risk behaviors, violence, anxiety, satisfaction during pregnancy, obstetric history and prenatal care. RESULTS: Poor housing conditions was independently associated with low birthweight (inadequate - OR 2.3 [1.1;4.6]; highly inadequate - OR 7.6 [2.1;27.6] and preterm low birthweight (inadequate - OR 2.2 [1.1;4.3]; highly inadequate - OR 7.6 [2.4;23.9] and factors associated with outcomes were inadequate prenatal care and previous preterm birth. Low income and low maternal body mass index remained associated with low birthweight. CONCLUSIONS: Poor housing conditions were associated with low birthweight and preterm low birthweight.
Ong, Bie Nio; Rogers, Anne; Kennedy, Anne; Bower, Peter; Sanders, Tom; Morden, Andrew; Cheraghi-Sohi, Sudeh; Richardson, Jane C; Stevenson, Fiona
Individual-focused self-management interventions are one response to both an ageing society and the purported increase in chronic conditions. They tend to draw on psychological theories in self-management interventions, but over-reliance on these theories can reinforce a narrow focus on specified attitudinal and behavioural processes, omitting aspects of living with a chronic condition. While advances have been made in health behaviour change theory and practice, scant attention has been paid to the social, with the question of social context remaining under-theorised and under-explored empirically. This is particularly noticeable in trials of behaviour change interventions for self-management. The common sociological critique is that these ignore context and thus no explanation can be given as to why, for whom and under what circumstances a treatment works. Conversely, sociologists are criticised for offering no positive suggestions as to how context can be taken into account and for over-emphasising context with the risk of inhibiting innovation. This article provides an overview of these issues and provides examples of how context can be incorporated into the rigid method of trials of self-management for chronic conditions. We discuss modifications to both trial interventions and design that make constructive use of the concept of context. © 2014 The Authors. Sociology of Health & Illness © 2014 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd.
Full Text Available Environmental conditions during early life may shape phenotype in adulthood. Early adverse conditions may increase the oxidative stress in adults, which could affect their reproductive output and survival. It has also been hypothesized that the larger the reproductive investment, the higher the oxidative stress. We tested this and the potential influence of early oxidative stress on how individuals respond to a reproductive stimulation. The synthesis of the antioxidant glutathione was inhibited in captive zebra finches (Taeniopygia guttata during growth. In adulthood, the expression of a carotenoid-based sexual signal, bill redness, increased in both sexes, with females also being heavier than controls. The social context of control and glutathione-inhibited males was then manipulated to stimulate precopulatory reproductive investments. Males were individually caged in front of a female or another male. We predicted that males enduring lower early antioxidant levels and placed close to a female should pay the highest cost of a hypothetical increase in bill redness in terms of oxidative damage. However, early conditions only influenced the male’s phenotype via their partners. Males caged with females showed increases in circulating pigment (carotenoid levels, but only when females endured early low antioxidant values. This was probably related to the higher attractiveness of these females. Nevertheless, the bill redness of males did not differ during the social manipulation. Moreover, males facing females from any early condition group showed lower oxidative damage levels in plasma lipids. This result agrees with some findings in rodents, also in captivity. However, the effect may be due to increased triglyceride levels and body mass in males not facing females, as variation in these traits explained oxidative damage variability. The importance of considering housing conditions and life history when interpreting oxidative stress-related trade
Full Text Available IntroductionChildhood cataract, congenital and traumatic, is the most common treatable cause of childhood blindness, being responsible for 10 to 30 per cent of all childhood blindness. Preventing blindness from childhood cataract requires not only high-quality paediatric surgery, but also an awareness of parents’ understanding of the eye problem, and why they might not agree to surgery for their child. Several studies have examined the medical and social aspects of childhood cataract. Foster et al.1 point out that childhood blindness has huge socio-economic costs, and restoring the sight of one child blind from cataract is considered equivalent to restoring the sight of 10 elderly adults. It is therefore crucial that we understand why parents might not take up the option of surgery.
Nahum-Shani, Inbal; Bamberger, Peter A; Bacharach, Samuel B
Seeking to explain divergent empirical findings regarding the direct effect of social support on well-being, the authors posit that the pattern of supportive exchange (i.e., reciprocal, under-, or over-reciprocating) determines the impact of receiving support on well-being. Findings generated on the basis of longitudinal data collected from a sample of older blue-collar workers support the authors' predictions, indicating that receiving emotional support is associated with enhanced well-being when the pattern of supportive exchange is perceived by an individual as being reciprocal (support received equals support given), with this association being weaker when the exchange of support is perceived as being under-reciprocating (support given exceeds support received). Moreover, receiving support was found to adversely affect well-being when the pattern of exchange was perceived as being over-reciprocating (support received exceeds support given). Theoretical and practical implications of these findings are discussed.
Schneider, Kellie; Rainwater, Chase; Pohl, Ed; Hernandez, Ivan; Ramirez-Marquez, Jose Emmanuel
This paper incorporates multi-state reliability measures into the assessment of a social network in which influence is treated as a multi-state commodity that flows through the network. The reliability of the network is defined as the probability that at least a certain level of influence reaches an intended target. We consider an individual's influence level as a function of the influence levels received from preceding actors in the network. We define several communication functions which describe the level of influence a particular actor will pass along to other actors within the network. Illustrative examples are presented, and the network reliability under the various communication influence levels is computed using exhaustive enumeration for a small example and Monte Carlo simulation for larger, more realistic sized examples.
Biquand, Sylvain; Heddad, Nadia
French companies are legally required to develop action plans to improve employment and work conditions for older workers ("plans seniors"). These plans contain measures oriented towards recruiting, career evolution, skills developme1nt, knowledge transmission and improvement of work conditions. A tool for assessing work situations experienced by council buildings caretakers ("gardiens") was used in such a plan on behalf of the main agency of council housing in Paris, and we developed. This assessment tool was developed after ergonomic work analysis on a sample of 36 older caretakers (age > 57 y.o). The technical inspectors in charge of technical interventions on buildings and managing caretakers were trained to use the assessment tool and apply it to all caretakers aged 50 and over.
Abstract: Changes in employment conditions since the 1980s have been referred to as precarious employment, and terms like flexible, atypical, temporary, part-time, contract, self-employed, irregular, or non-standard employment have also been used. In this essay I review some of the current critiques to the precarious employment construct and advance some potential solutions for its use in epidemiology and public health.
Panthi, Krishna Kanta
Rock burst / rock spalling is among the prevailing stability challenges, which can be met while tunneling through hard rock mass. Especially, this is very relevant for the mountainous country like Norway where hard rock is dominating and many road, railway and hydropower tunnels have to be aligned deep into the mountain with steep valley slope topography. Tunnels passing beneath deep rock cover (overburden), in general, are subjected to high in-situ stresses. If the rock mass is relatively un...
The author first shows that the share of nuclear energy in the French electricity production is in fact of 76% (and not 80% as usually said), and that the share of this energy in the final electricity consumption was 69% in 2009. She also outlines that nuclear electricity is only 16,5% of the total final energy consumption in France in 2009, whereas oil still prevails with 42%
Abstract: Changes in employment conditions since the 1980s have been referred to as precarious employment, and terms like flexible, atypical, temporary, part-time, contract, self-employed, irregular, or non-standard employment have also been used. In this essay I review some of the current critiques to the precarious employment construct and advance some potential solutions for its use in epidemiology and public health. Resumo: Mudanças nas condições de emprego desde os anos 1980s têm sido...
Farji-Brener, Alejandro G; Elizalde, Luciana; Fernández-Marín, Hermógenes; Amador-Vargas, Sabrina
Adequate waste management is vital for the success of social life, because waste accumulation increases sanitary risks in dense societies. We explored why different leaf-cutting ants (LCA) species locate their waste in internal nest chambers or external piles, including ecological context and accounting for phylogenetic relations. We propose that waste location depends on whether the environmental conditions enhance or reduce the risk of infection. We obtained the geographical range, habitat and refuse location of LCA from published literature, and experimentally determined whether pathogens on ant waste survived to the high soil temperatures typical of xeric habitats. The habitat of the LCA determined waste location after phylogenetic correction: species with external waste piles mainly occur in xeric environments, whereas those with internal waste chambers mainly inhabit more humid habitats. The ancestral reconstruction suggests that dumping waste externally is less derived than digging waste nest chambers. Empirical results showed that high soil surface temperatures reduce pathogen prevalence from LCA waste. We proposed that LCA living in environments unfavourable for pathogens (i.e. xeric habitats) avoid digging costs by dumping the refuse above ground. Conversely, in environments suitable for pathogens, LCA species prevent the spread of diseases by storing waste underground, presumably, a behaviour that contributed to the colonization of humid habitats. These results highlight the adaptation of organisms to the hygienic challenges of social living, and illustrate how sanitary behaviours can result from a combination of evolutionary history and current environmental conditions. © 2016 The Author(s).
Full Text Available In this work we describe for the first time the social and reproductive behavior of the Neotropical fish Cichlasoma dimerus (Heckel, 1840 [Perciformes: Cichlidae], endemic to the Paraná River basin, using a comprehensive-integral approach, including morphological and physiological features. This substrate breeding fish has biparental care of the fry and presents a dominance hierarchy that determines access to breeding territories among males, and to males with territories among females. Gregarious behavior associated with a pale body color, was observed before reproductive behaviors started. Afterwards, a dominance hierarchy was established through aggressive interactions. Territorial individuals had bright body color patterns and non territorial an opaque grey one. Black ventral coloration was associated with reproductive individuals. Courtship displays, which were similar to threatening displays, had the common effect of increasing the visible area of the individual. The dominant male was always the largest one suggesting that size is probably a major factor determining the hierarchy establishment and that these intra-sexually selected traits may have been reinforced by inter-sexual selection. Reproductive males had higher pituitary levels of β-follicle stimulating hormone (β-FSH and somatolactin (SL than non reproductive ones, while no differences were found among females. No differences were found among male gonadosomatic indexes. Non reproductive individuals had higher plasma cortisol levels for both sexes. It is possible that dominant reproductive individuals may be inhibiting reproduction of subordinate fish through physical contact, increasing their cortisol levels and diminishing FSH and SL pituitary content. However, this was not reflected as an inhibition at the gonadal level in our experimental design.
Bill D Wills
Full Text Available Resource availability can determine an organism's investment strategies for growth and reproduction. When nutrients are limited, there are potential tradeoffs between investing into offspring number versus individual offspring size. In social insects, colony investment in offspring size and number may shift in response to colony needs and the availability of food resources. We experimentally manipulated the diet of a polymorphic ant species (Solenopsis invicta to test how access to the carbohydrate and amino acid components of nectar resources affect colony investment in worker number, body size, size distributions, and individual percent fat mass. We reared field-collected colonies on one of four macronutrient treatment supplements: water, amino acids, carbohydrates, and amino acid and carbohydrates. Having access to carbohydrates nearly doubled colony biomass after 60 days. This increase in biomass resulted from an increase in worker number and mean worker size. Access to carbohydrates also altered worker body size distributions. Finally, we found a negative relationship between worker number and size, suggesting a tradeoff in colony investment strategies. This tradeoff was more pronounced for colonies without access to carbohydrate resources. The monopolization of plant-based resources has been implicated in the ecological success of ants. Our results shed light on a possible mechanism for this success, and also have implications for the success of introduced species. In addition to increases in colony size, our results suggest that having access to plant-based carbohydrates can also result in larger workers that may have better individual fighting ability, and that can withstand greater temperature fluctuations and periods of food deprivation.
Baker, Michael G; Zhang, Jane; Blakely, Tony; Crane, Julian; Saville-Smith, Kay; Howden-Chapman, Philippa
Despite the importance of adequate, un-crowded housing as a prerequisite for good health, few large cohort studies have explored the health effects of housing conditions. The Social Housing Outcomes Worth (SHOW) Study was established to assess the relationship between housing conditions and health, particularly between household crowding and infectious diseases. This paper reports on the methods and feasibility of using a large administrative housing database for epidemiological research and the characteristics of the social housing population. This prospective open cohort study was established in 2003 in collaboration with Housing New Zealand Corporation which provides housing for approximately 5% of the population. The Study measures health outcomes using linked anonymised hospitalisation and mortality records provided by the New Zealand Ministry of Health. It was possible to match the majority (96%) of applicant and tenant household members with their National Health Index (NHI) number allowing linkage to anonymised coded data on their hospitalisations and mortality. By December 2011, the study population consisted of 11,196 applicants and 196,612 tenants. Half were less than 21 years of age. About two-thirds identified as Māori or Pacific ethnicity. Household incomes were low. Of tenant households, 44% containing one or more smokers compared with 33% for New Zealand as a whole. Exposure to household crowding, as measured by a deficit of one or more bedrooms, was common for applicants (52%) and tenants (38%) compared with New Zealanders as whole (10%). This project has shown that an administrative housing database can be used to form a large cohort population and successfully link cohort members to their health records in a way that meets confidentiality and ethical requirements. This study also confirms that social housing tenants are a highly deprived population with relatively low incomes and high levels of exposure to household crowding and environmental
Michael G. Baker
Full Text Available Abstract Background Despite the importance of adequate, un-crowded housing as a prerequisite for good health, few large cohort studies have explored the health effects of housing conditions. The Social Housing Outcomes Worth (SHOW Study was established to assess the relationship between housing conditions and health, particularly between household crowding and infectious diseases. This paper reports on the methods and feasibility of using a large administrative housing database for epidemiological research and the characteristics of the social housing population. Methods This prospective open cohort study was established in 2003 in collaboration with Housing New Zealand Corporation which provides housing for approximately 5 % of the population. The Study measures health outcomes using linked anonymised hospitalisation and mortality records provided by the New Zealand Ministry of Health. Results It was possible to match the majority (96 % of applicant and tenant household members with their National Health Index (NHI number allowing linkage to anonymised coded data on their hospitalisations and mortality. By December 2011, the study population consisted of 11,196 applicants and 196,612 tenants. Half were less than 21 years of age. About two-thirds identified as Māori or Pacific ethnicity. Household incomes were low. Of tenant households, 44 % containing one or more smokers compared with 33 % for New Zealand as a whole. Exposure to household crowding, as measured by a deficit of one or more bedrooms, was common for applicants (52 % and tenants (38 % compared with New Zealanders as whole (10 %. Conclusions This project has shown that an administrative housing database can be used to form a large cohort population and successfully link cohort members to their health records in a way that meets confidentiality and ethical requirements. This study also confirms that social housing tenants are a highly deprived population with relatively low
Tougas, Michelle E; Hayden, Jill A; McGrath, Patrick J; Huguet, Anna; Rozario, Sharlene
Theory is often recommended as a framework for guiding hypothesized mechanisms of treatment effect. However, there is limited guidance about how to use theory in intervention development. We conducted a systematic review to provide an exemplar review evaluating the extent to which use of theory is identified and incorporated within existing interventions. We searched electronic databases PubMed, PsycINFO, CENTRAL, and EMBASE from inception to May 2014. We searched clinicaltrials.gov for registered protocols, reference lists of relevant systematic reviews and included studies, and conducted a citation search in Web of Science. We included peer-reviewed publications of interventions that referenced the social cognitive theory of self-regulation as a framework for interventions to manage chronic health conditions. Two reviewers independently assessed articles for eligibility. We contacted all authors of included studies for information detailing intervention content. We describe how often theory mechanisms were addressed by interventions, and report intervention characteristics used to address theory. Of 202 articles that reported using the social cognitive theory of self-regulation, 52% failed to incorporate self-monitoring, a main theory component, and were therefore excluded. We included 35 interventions that adequately used the theory framework. Intervention characteristics were often poorly reported in peer-reviewed publications, 21 of 35 interventions incorporated characteristics that addressed each of the main theory components. Each intervention addressed, on average, six of eight self-monitoring mechanisms, two of five self-judgement mechanisms, and one of three self-evaluation mechanisms. The self-monitoring mechanisms 'Feedback' and 'Consistency' were addressed by all interventions, whereas the self-evaluation mechanisms 'Self-incentives' and 'External rewards' were addressed by six and four interventions, respectively. The present review establishes that
Guida-Johnson, Bárbara; Zuleta, Gustavo A
In the present context of global change and search for sustainability, we detected a gap between restoration and society: local communities are usually only considered as threats or disturbances when planning for restoration. To bridge this gap, we propose a landscape design framework for planning riparian rehabilitation in an urban-rural gradient. A spatial multi-criteria analysis was used to assess the priority of riversides by considering two rehabilitation objectives simultaneously-socio-environmental and ecological-and two sets of criteria were designed according to these objectives. The assessment made it possible to identify 17 priority sites for riparian rehabilitation that were associated with different conditions along the gradient. The double goal setting enabled a dual consideration of citizens, both as beneficiaries and potential impacts to rehabilitation, and the criteria selected incorporated the multi-dimensional nature of the environment. This approach can potentially be adapted and implemented in any other anthropic-natural interface throughout the world.
Full Text Available Without a solid education at home, children in institutions can develop behaviors and trauma, often impossible to mitigate. The absence of an emotional climate specific in a family, abuses of various types that can accompany the trajectory of institutionalization will mark, perhaps forever, the fate of children in institutions. The chances of these children to grow and to form independent life skills to succeed as future adults can often be reduced. Decision makers within state institutions that are meant to care and educate, are summoned to identify and implement measures that may secure the future for these disadvantaged and vulnerable children. Based on these considerations, the study conducted aims to highlight the condition of children in institutions in Arad County, the causes for their abandonment, schooling situation, contact with the family of origin.
Heyting, G.F.; Kruithof, B.; Mulder, E.
Examines approaches to social integration and its educational implications. Prevailing way of relating education to social integration resting on the thesis of social integration depending on a foundation of shared societal values; Suggestion that social integration cannot be affected by
Super, Sabina; Verkooijen, Kirsten; Koelen, Maria
Sport is widely recognised as having the potential to enhance the personal development of socially vulnerable youth, yet there is very limited knowledge on how community sports coaches can create optimal social conditions for life skill development and transferability. We adopt a salutogenic approach in order to study whether and how community…
Cramm Jane M
Full Text Available Abstract Background Surprisingly few studies have investigated the interplay of multiple factors affecting self-rated health outcomes and the role of social capital on health in developing countries, a prerequisite to strengthening our understanding of the influence of social and economic conditions on health and the most effective aid. Our study aimed to identify social and economic conditions for health among residents of an economically and health-deprived community. Methods Data were gathered through a survey administered to respondents from 1,020 households in Grahamstown a suburb in the Eastern Cape, South Africa (response rate 97.9%. We investigated the influence of social and economic conditions (education, employment, income, social capital, housing quality and neighborhood quality on self-rated health. We used ordinal logistic regression analyses to identify the relationship of these conditions and self-rated health. Results Our study found that education and social capital positively correlated with health; unemployment, poor educational level and advanced age negatively correlated. We found no significant correlations between self-rated health and housing quality, neighbourhood quality, income, gender, or marital status. Conclusion We highlight the possible impacts of social capital, employment, and education on health, and suggest that health outcomes may be improved through interventions beyond the health system: creating job opportunities, strengthening social capital, bettering educational systems, and promoting educational access. Policymakers should consider the benefits of such programmes when addressing health outcomes in financially distressed districts.
J.M. Cramm (Jane); A.P. Nieboer (Anna)
textabstractThe use of variably self-reported measures of wellbeing may produce differing outcomes. This study examined the differences in association with health, socioeconomic status, and social conditions (marital status, social capital) of two widely used cognitive subjective wellbeing
Álvaro Franco G
Full Text Available Social protection includes all the economic, political and social variables that guarantee protection amidst the adversity that can damage the rights to health, employment, well-being, and quality of life. Objective: to unveil the link between the systems of social protection in Latin America and the fulfillment of social rights. Method: from the start point of documentary revision, a comparison among the different models of social protection applied in Latin America and the diverse types of citizen rights in the last decades is carried out. Several approaches of social protection are considered: social attendance, social security and social insurance; and additionally, the Minimum Networks of Social Protection (m n s p of the 80’s, and the recent social protection as social risk management of the World Bank. The classification of the human rights are again took up: civil, political and social rights.Discussion: difficulties in Latin America that condition the model of social protection according to differences among social levels, the fragmentation of the social policy and the prevailing conditions of inequity that deny the possibilities of citizen rights to be effective are pointed out. In conclusion, the total fulfillment of social rights is feasible through the development of models of social protection capable of covering all the population and all the implied risks, not only in the work by itself but in the integral human development.
Full Text Available Abstract Background There is limited epidemiological research that provides insight into the complex web of causative and moderating factors that links housing conditions to a variety of poor health outcomes. This study explores the relationship between housing conditions (with a primary focus on the functional state of infrastructure and common childhood illness in remote Australian Aboriginal communities for the purpose of informing development of housing interventions to improve child health. Methods Hierarchical multi-level analysis of association between carer report of common childhood illnesses and functional and hygienic state of housing infrastructure, socio-economic, psychosocial and health related behaviours using baseline survey data from a housing intervention study. Results Multivariate analysis showed a strong independent association between report of respiratory infection and overall functional condition of the house (Odds Ratio (OR 3.00; 95%CI 1.36-6.63, but no significant association between report of other illnesses and the overall functional condition or the functional condition of infrastructure required for specific healthy living practices. Associations between report of child illness and secondary explanatory variables which showed an OR of 2 or more included: for skin infection - evidence of poor temperature control in the house (OR 3.25; 95%CI 1.06-9.94, evidence of pests and vermin in the house (OR 2.88; 95%CI 1.25-6.60; for respiratory infection - breastfeeding in infancy (OR 0.27; 95%CI 0.14-0.49; for diarrhoea/vomiting - hygienic state of food preparation and storage areas (OR 2.10; 95%CI 1.10-4.00; for ear infection - child care attendance (OR 2.25; 95%CI 1.26-3.99. Conclusion These findings add to other evidence that building programs need to be supported by a range of other social and behavioural interventions for potential health gains to be more fully realised.
Grotewold, Susan K.; Wall, Vanessa L.; Goodell, Dayton J.; Hayter, Cassandra
Rationale Social interaction during drug exposure can potentiate cocaine reward. Isolation rearing (ISO) during adolescence increases social interaction and may amplify this potentiation. Objectives The objectives of this study are to determine whether ISO alters conditioned place preference (CPP) for cocaine when combined with a social cue and to determine whether ISO alters the effects of cocaine when combined with social cue on nucleus accumbens shell (NAcS) dopamine (DA) and serotonin (5-HT). Methods Male and female rats were either ISO or group (GRP) reared for 4 weeks during adolescence. CPP was performed using a low dose of cocaine (2 mg/kg or saline) with or without exposure to a novel same-sex conspecific during conditioning. In vivo microdialysis was performed using the same parameters. Results ISO rats engaged in more social and aggressive behaviors during conditioning relative to GRP. Cocaine reduced social and aggressive behaviors in all rats. CPP was not influenced by rearing condition. Cocaine produced significant CPP, and a social cue produced CPP only in males. In contrast, the interaction of cocaine and a social cue on NAcS DA and 5-HT differed depending upon rearing condition. In isolates, cocaine-induced DA was attenuated, while cocaine plus a social cue produced potentiated DA and 5-HT. Conclusions Exposure to a low dose of cocaine in the presence of a social cue produced additive effects on CPP while producing synergistic effects on DA and 5-HT in the NAcS of ISO rats. The aversive effects of this compound stimulus may negate the rewarding effects in isolates. PMID:24553577
Galbraith, Todd; Heimberg, Richard G; Wang, Shuai; Schneier, Franklin R; Blanco, Carlos
Social anxiety disorder (SAD) and antisocial personality disorder (ASPD) are not often thought of as being comorbid. However, recent research suggests the existence of a SAD subtype with characteristics atypical of SAD but common to ASPD. Thus, we explored two competing hypotheses: (1) SAD and ASPD represent opposite ends of a single dimension, or (2) SAD and ASPD exist on two separate dimensions that may be positively correlated. Data were obtained from the National Epidemiological Survey on Alcohol and Related Conditions. SAD-ASPD was related to greater impairment and psychiatric comorbidity than either disorder alone. The SAD-ASPD group was also more likely to seek treatment for their SAD symptoms and to drink before/during antisocial acts than the SAD only group. The presence of SAD for individuals with ASPD (and vice versa) does not appear to provide any "protective benefits." SAD and ASPD appear to be two separate but correlated disorders. Copyright © 2013 Elsevier Ltd. All rights reserved.
Galbraith, Todd; Heimberg, Richard G.; Wang, Shuai; Schneier, Franklin R.; Blanco, Carlos
Social anxiety disorder (SAD) and antisocial personality disorder (ASPD) are not often thought of as being comorbid. However, recent research suggests the existence of a SAD subtype with characteristics atypical of SAD but common to ASPD. Thus, we explored two competing hypotheses: 1) SAD and ASPD represent opposite ends of a single dimension, or 2) SAD and ASPD exist on two separate dimensions that may be positively correlated. Data were obtained from the National Epidemiological Survey on Alcohol and Related Conditions. SAD-ASPD was related to greater impairment and psychiatric comorbidity than either disorder alone. The SAD-ASPD group was also more likely to seek treatment for their SAD symptoms and to drink before/during antisocial acts than the SAD only group. The presence of SAD for individuals with ASPD (and vice versa) does not appear to provide any “protective benefits.” SAD and ASPD appear to be two separate but correlated disorders. PMID:24384071
Michelle E Tougas
Full Text Available Theory is often recommended as a framework for guiding hypothesized mechanisms of treatment effect. However, there is limited guidance about how to use theory in intervention development.We conducted a systematic review to provide an exemplar review evaluating the extent to which use of theory is identified and incorporated within existing interventions. We searched electronic databases PubMed, PsycINFO, CENTRAL, and EMBASE from inception to May 2014. We searched clinicaltrials.gov for registered protocols, reference lists of relevant systematic reviews and included studies, and conducted a citation search in Web of Science. We included peer-reviewed publications of interventions that referenced the social cognitive theory of self-regulation as a framework for interventions to manage chronic health conditions. Two reviewers independently assessed articles for eligibility. We contacted all authors of included studies for information detailing intervention content. We describe how often theory mechanisms were addressed by interventions, and report intervention characteristics used to address theory.Of 202 articles that reported using the social cognitive theory of self-regulation, 52% failed to incorporate self-monitoring, a main theory component, and were therefore excluded. We included 35 interventions that adequately used the theory framework. Intervention characteristics were often poorly reported in peer-reviewed publications, 21 of 35 interventions incorporated characteristics that addressed each of the main theory components. Each intervention addressed, on average, six of eight self-monitoring mechanisms, two of five self-judgement mechanisms, and one of three self-evaluation mechanisms. The self-monitoring mechanisms 'Feedback' and 'Consistency' were addressed by all interventions, whereas the self-evaluation mechanisms 'Self-incentives' and 'External rewards' were addressed by six and four interventions, respectively. The present review
Reddy, Vivek Y; Doshi, Shephal K; Kar, Saibal; Gibson, Douglas N; Price, Matthew J; Huber, Kenneth; Horton, Rodney P; Buchbinder, Maurice; Neuzil, Petr; Gordon, Nicole T; Holmes, David R
The PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation) trial demonstrated that left atrial appendage closure (LAAC) with the Watchman device (Boston Scientific, St. Paul, Minnesota) was equivalent to warfarin for preventing stroke in atrial fibrillation, but had a high rate of complications. In a second randomized trial, PREVAIL (Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy), the complication rate was low. The warfarin cohort experienced an unexpectedly low ischemic stroke rate, rendering the efficacy endpoints inconclusive. However, these outcomes were based on relatively few patients followed for a relatively short time. The final results of the PREVAIL trial, both alone and as part of a patient-level meta-analysis with the PROTECT AF trial, are reported with patients in both trials followed for 5 years. PREVAIL and PROTECT AF are prospective randomized clinical trials with patients randomized 2:1 to LAAC or warfarin; together, they enrolled 1,114 patients for 4,343 patient-years. Analyses are by intention-to-treat, and rates are events per 100 patient-years. For the PREVAIL trial, the first composite coprimary endpoint of stroke, systemic embolism (SE), or cardiovascular/unexplained death did not achieve noninferiority (posterior probability for noninferiority = 88.4%), whereas the second coprimary endpoint of post-procedure ischemic stroke/SE did achieve noninferiority (posterior probability for noninferiority = 97.5%); the warfarin arm maintained an unusually low ischemic stroke rate (0.73%). In the meta-analysis, the composite endpoint was similar between groups (hazard ratio [HR]: 0.820; p = 0.27), as were all-stroke/SE (HR: 0.961; p = 0.87). The ischemic stroke/SE rate was numerically higher with LAAC, but this difference did not reach statistical significance (HR: 1.71; p = 0.080). However, differences in
Full Text Available The purpose of this study is to analyze the labor and social environment that prevails in the maquiladoras (assemble plants located in the northern border states of México, particularly in the state of Coahuila; also it is addressed the importance of factors contributing to improve labor conditions and productivity. The study is based in a sample of 20 firms located in the counties of Saltillo, Ramos Arizpe, Monclova, Torreón, Sabinas, Piedras Negras and Ciudad Acuña. This study analizes the main socialeconomic figures of the workers, their labor conditions in regard to labor security, training, rights and duties, social security and social environment in which they live in. Conclusions and recommendations are related to improving training and labor conditions, as well as fostering a new labor culture, health, social security and social environment.
Kummer, Kai K; El Rawas, Rana; Kress, Michaela; Saria, Alois; Zernig, Gerald
Both cocaine and social interaction place preference conditioning lead to increased neuronal expression of the immediate early gene EGR1 in the nucleus accumbens, a central region of the reward pathway, suggesting that both drug and natural rewards may be processed in similar brain regions. In order to gain novel insights into the intrinsic in vitro electrical activity of the nucleus accumbens and adjacent brain regions and to explore the effects of reward conditioning on network activity, we performed multielectrode array recordings of spontaneous firing in acute brain slices of mice conditioned to either cocaine or social interaction place preference. Cocaine conditioning increased the spike frequency of neurons in the septal nuclei, whereas social interaction conditioning increased the spike frequency in the nucleus accumbens compared to saline control animals. In addition, social interaction conditioning decreased the amount of active neuron clusters in the nucleus accumbens. Our findings suggest that place preference conditioning for both drug and natural rewards may induce persistent changes in neuronal network activity in the nucleus accumbens and the septum that are still preserved in acute slice preparations. © 2015 S. Karger AG, Basel.
Full Text Available Technological utopianism seduces many people, from the very origins of Western modernity –remember Francis Bacon’s island of Bensalem in his New Atlantis–, with the temptation of complete mastery over nature (which includes human immortality. Today, the prevailing mentality in the West, which tends to become a universal worldview, has much in common with the beliefs of the ancient Gnostics. According to this mindset, science and technology can allow the human mind to escape the limitations that characterize its natural state, releasing the anchor to biological stuff and escaping the human condition. In short, we would become gods –gods thought of as Immortal Super-Engineers. We must resist these destructive illusions and delusions, which means: technical rationality has to make his own critique of utopian reason (in the sense of Franz Hinkelammert. Without this self-criticism, a judicious use of techniques and technologies will be out of reach –and they do have an enormous potential for improving the human condition–, while avoiding –if it were still possible– the exterminist, nihilistic and suicidal drift of industrial civilization.
Hotter and drier conditions in the near future (2010-2035) might paradoxically improve the general adaptive capacity of a viticultural social-ecological system in Roussillon, southern France, exposed to long-term climatic and economic changes
Lereboullet, Anne-Laure; Beltrando, Gérard
Background: Wine production in Roussillon, southern France, has been subjected to deep structural changes in cultural practices since the 1970's, due to changes in demand and market organization. In this Mediterranean region, temperature and rainfall parameters have long been adapted to fortified wine production, but might be less suited to dry wine production, which is nowadays prevailing. The wine industry in Roussillon can be studied as a social-ecological system where local economical and social characteristics are strongly linked to physical inputs. Thus changes in climate, especially warming and drying trends that have been detected and projected by the IPCC in the Mediterranean basin, may disrupt the local economy and social organization in the long term. The aim of our study is to assess the role played by recent (1956-2010) and near-future (2010-2035) changes in temperature and rainfall inputs in the evolution of the system's adaptive capacity to combined long term climatic and economic changes. Methods: Our study combined quantitative and qualitative data. We first assessed recent exposure to climate change by analysing change in daily data of temperature and rainfall observed in Perpignan weather station from 1956 to 2010. Thirty-nine in-depth interviews with local producers and key stakeholders of the local wine industry helped us understand the impacts of recent climatic conditions in the system's adaptive capacity. Then, we measured future changes in temperature and rainfall based on daily data simulated by ARPEGE-Climat (SCRATCH10 dataset) at an 8-km spatial scale, for emission scenarios A2, A1B and B1, up to 2060. Based on the impacts of recent changes in the system, we inferred the possible impacts of future climate change on the system's equilibrium. Results and discussion: Climate data analyses show that changes in temperatures and rainfall patterns have occurred in Perpignan since the mid-1980's, and that current (2001-2010) conditions are
Goodman, Heather; Egizi, Andrea; Fonseca, Dina M; Leisnham, Paul T; LaDeau, Shannon L
Temperate urban landscapes support persistent and growing populations of Culex and Aedes mosquito vectors. Large urban mosquito populations can represent a significant risk for transmission of emergent arboviral infection. However, even large mosquito populations are only a risk to the animals they bite. The purpose of this study is to identify and assess spatial patterns of host-use in a temperate urban landscape with heterogeneous socio-economic and ecological conditions. Mosquito blood meals were collected from neighborhoods categorized along a socio-economic gradient in Baltimore, MD, USA. Blood meal hosts were identified for two Aedes (Ae. albopictus and Ae. japonicus) and three Culex (Cx. pipiens, Cx. restuans and Cx. salinarius) species. The brown rat (Rattus norvegicus) was the most frequently detected host in both Aedes species and Cx. salinarius. Human biting was evident in Aedes and Culex species and the proportion of human blood meals from Ae. albopictus varied significantly with neighborhood socio-economic status. Aedes albopictus was most likely to feed on human blood hosts (at 50%) in residential blocks categorized as having income above the city median, although there were still more total human bites detected from lower income blocks where Ae. albopictus was more abundant. Birds were the most frequently detected Culex blood hosts but were absent from all Aedes sampled. This study highlights fine-scale variation in host-use by medically important mosquito vectors and specifically investigates blood meal composition at spatial scales relevant to urban mosquito dispersal and human exposure. Further, the work emphasizes the importance of neighborhood economics and infrastructure management in shaping both the relative abundance of vectors and local blood feeding strategies. The invasive brown rat was an important blood source across vector species and neighborhoods in Baltimore. We show that social and economic conditions can be important predictors of
Emilia van Egmond-deWilde de Ligny
Full Text Available The diffusion of innovative technologies in the market is usually a complex and difficult process with a varying degree of success and the effects of the diffused innovative technologies are very un-balanced. The objective of our research is to gain insight into the reasons why the diffusion of innovative technology fails, even though they promise a superior performance compared to incumbent technologies. Drawing on innovation systems theories, we have identified and used the concepts of technological regime, actor network and technology sets to analyze technology diffusion in a case study in the dwelling construction industry in Costa Rica. The results showed bottlenecks in the prevailing innovation system that curtailed the diffusion of an innovative construction technology.
Pineo, Graham; Lin, Jay; Stern, Lee; Subrahmanian, Tarun; Annemans, Lieven
The efficacy and safety of low-molecular-weight heparins (LMWHs) versus unfractionated heparin (UFH) has been demonstrated for the prevention of venous thromboembolism (VTE) after acute ischemic stroke. Few data exist regarding the economic impact of LMWHs versus UFH in this population. A decision-analytic model was constructed using clinical information from the Prevention of VTE after Acute Ischemic stroke with LMWH Enoxaparin (PREVAIL) study, and drug costs and mean Centers for Medicare & Medicaid Services event costs. When considering the total cost of events and drugs, enoxaparin was associated with cost-savings of $895 per patient compared with UFH ($2018 vs $2913). Findings were retained within the univariate and multivariate analyses. From a payer perspective, enoxaparin was cost-effective compared with UFH in patients with acute ischemic stroke. The difference was driven by the lower clinical event rates with enoxaparin. Use of enoxaparin may help to reduce the clinical and economic burden of VTE.
M A Marinova
Full Text Available The article considers basic principles of socially-oriented economy according to L. Erhard's model applied in Germany after World War II. It provides the analysis of their advantages and disadvantages, outlines the main subjects of economic relations and specifies the ways to implement the principles of socially-oriented market economy.
Full Text Available The article discusses factors influencing language maintenance under changing social, cultural, economic and political conditions of Polish minority in Siberia. The village of Vershina was founded in 1910 by Polish voluntary settlers from Little Poland.During its first three decades Vershina preserved Polish language,traditions, farming methods and machines and also the Roman Catholic religion. The changes came to a village in taiga in the1930s. Vershina lost its ethnocultural homogeneity because of Russian and Buryat workers in the local kolkhoz. Nowadays the inhabitants of Vershina regained their minority rights: religious, educational and cultural. However, during the years of sovietization and ateization, their culture and customs became much more similar to other Siberian villages. Polish language in Vershina is under strong influence of Russian, which is the language of education,administration, and surrounding villages. Children from Polish-Russian families become monolingual and use Polish very rare, only asa school subject and in contacts with grandparents. The process of abandoning mother tongue in Vershina is growing rapidly. However,there are some factors which may hinder the actual changes:the activity of local Polish organisations and Roman Catholic parish as well as folk group “Jazhumbek”.
El Rawas, Rana; Klement, Sabine; Salti, Ahmad; Fritz, Michael; Dechant, Georg; Saria, Alois; Zernig, Gerald
The worsening of drug abuse by drug-associated social interaction is a well-studied phenomenon. In contrast, the molecular mechanisms of the beneficial effect of social interaction, if offered as a mutually exclusive choice to drugs of abuse, are under-investigated. In a rat place preference conditioning (CPP) paradigm, four 15 min episodes of social interaction with a gender- and weight-matched male early-adult conspecific inhibited cocaine-induced reinstatement of cocaine CPP, a model of relapse. These protective effects of social interaction were paralleled by a reduced activation, as assessed by Zif268 expression, in brain areas known to play pivotal roles in drug-seeking behavior. Here we show that social interaction during extinction of cocaine CPP also reduced cocaine-CPP-stimulated FosB expression in the nucleus accumbens shell and core. In addition, social interaction during cocaine CPP extinction increased pCREB (cAMP response element binding protein) expression in the nucleus accumbens shell and the cingulate cortex area 1 (Cg1). Our results show that FosB and pCREB may be implicated in the protective effect of social interaction against cocaine-induced reinstatement of CPP. Thus, social interaction, if offered in a context that is clearly distinct from the previously drug-associated one, may profoundly inhibit relapse to cocaine addiction. PMID:22403532
El Rawas, Rana; Klement, Sabine; Salti, Ahmad; Fritz, Michael; Dechant, Georg; Saria, Alois; Zernig, Gerald
The worsening of drug abuse by drug-associated social interaction is a well-studied phenomenon. In contrast, the molecular mechanisms of the beneficial effect of social interaction, if offered as a mutually exclusive choice to drugs of abuse, are under-investigated. In a rat place preference conditioning (CPP) paradigm, four 15 min episodes of social interaction with a gender- and weight-matched male early-adult conspecific inhibited cocaine-induced reinstatement of cocaine CPP, a model of relapse. These protective effects of social interaction were paralleled by a reduced activation, as assessed by Zif268 expression, in brain areas known to play pivotal roles in drug-seeking behavior. Here we show that social interaction during extinction of cocaine CPP also reduced cocaine-CPP-stimulated FosB expression in the nucleus accumbens shell and core. In addition, social interaction during cocaine CPP extinction increased pCREB (cAMP response element binding protein) expression in the nucleus accumbens shell and the cingulate cortex area 1 (Cg1). Our results show that FosB and pCREB may be implicated in the protective effect of social interaction against cocaine-induced reinstatement of CPP. Thus, social interaction, if offered in a context that is clearly distinct from the previously drug-associated one, may profoundly inhibit relapse to cocaine addiction.
Personality traits have been directly associated with happiness. One consistent finding is a strong link between extraversion and happiness: extraverts are happier than introverts. Although happy introverts exist, it is currently unclear under what conditions they can achieve happiness. The present study analyzes, generally, how the quality of social relationships and emotion regulation ability influence happiness and, specifically, how these factors can lead introverts to be happy. In the present study, 1,006 participants aged 18–80 (42% males) completed measures of extraversion, neuroticism, quality of social relationships, emotion regulation ability, and happiness. We found that extraverts had significantly higher happiness, quality of social relationships and emotion regulation ability scores than introverts. In addition, people with high quality social relationships or high emotion regulation ability were happier. Serial mediation analyses indicated that greater levels of extraversion were associated with greater happiness, with small effect size, via two indirect mechanisms: (a) higher quality of social relationships, and (b) higher quality of social relationships followed serially by higher emotion regulation ability. We also found a moderating effect due to the three-way interaction of extraversion, quality of social relationships, and emotion regulation ability: introverts were happier when they had high scores for these two variables, though the effect size was small. These results suggest that the quality of social relationships and emotion regulation ability are relevant to our understanding of complex associations between extraversion and happiness. PMID:26500814
Rana eEl Rawas
Full Text Available The worsening of drug abuse by drug-associated social interaction is a well-studied phenomenon. In contrast, the molecular mechanisms of the beneficial effect of social interaction, if offered as a mutually exclusive choice to drugs of abuse, are under-investigated. In a rat place preference conditioning (CPP paradigm, four 15 min episodes of social interaction with a gender- and weight matched male early-adult conspecific inhibited cocaine-induced reinstatement of cocaine CPP, a model of relapse. These protective effects of social interaction were paralleled by a reduced activation, as assessed by Zif268 expression in brain areas known to play pivotal roles in drug-seeking behavior. Here we show that social interaction during extinction of cocaine CPP also reduced cocaine-CPP-stimulated FosB expression in the nucleus accumbens shell and core. In addition, social interaction during cocaine CPP extinction increased pCREB (cAMP response element binding protein expression in the nucleus accumbens shell and the cingulate cortex area 1 (Cg1. Our results show that FosB and pCREB may be implicated in the protective effect of social interaction against cocaine-induced reinstatement of CPP. Thus, social interaction, if offered in a context that is clearly distinct from the previously drug-associated one, may profoundly inhibit relapse to cocaine addiction.
Cabello, Rosario; Fernandez-Berrocal, Pablo
Personality traits have been directly associated with happiness. One consistent finding is a strong link between extraversion and happiness: extraverts are happier than introverts. Although happy introverts exist, it is currently unclear under what conditions they can achieve happiness. The present study analyzes, generally, how the quality of social relationships and emotion regulation ability influence happiness and, specifically, how these factors can lead introverts to be happy. In the present study, 1,006 participants aged 18-80 (42% males) completed measures of extraversion, neuroticism, quality of social relationships, emotion regulation ability, and happiness. We found that extraverts had significantly higher happiness, quality of social relationships and emotion regulation ability scores than introverts. In addition, people with high quality social relationships or high emotion regulation ability were happier. Serial mediation analyses indicated that greater levels of extraversion were associated with greater happiness, with small effect size, via two indirect mechanisms: (a) higher quality of social relationships, and (b) higher quality of social relationships followed serially by higher emotion regulation ability. We also found a moderating effect due to the three-way interaction of extraversion, quality of social relationships, and emotion regulation ability: introverts were happier when they had high scores for these two variables, though the effect size was small. These results suggest that the quality of social relationships and emotion regulation ability are relevant to our understanding of complex associations between extraversion and happiness.
Full Text Available Abstract Background Increasing the effective targeting and promotion of self-care support for long-term conditions requires more of a focus on patient contexts and networks. The aim of this paper is to describe how within a programme of research and implementation, social networks are viewed as being centrally involved in the mobilisation and deployment of resources in the management of a chronic condition. This forms the basis of a novel approach to understanding, designing, and implementing new forms of self-management support. Methods Drawing on evidence syntheses about social networks and capital and the role of information in self-management, we build on four conceptual approaches to inform the design of our research on the implementation of self-care support for people with long-term conditions. Our approach takes into consideration the form and content of social networks, notions of chronic illness work, normalisation process theory (NPT, and the whole systems informing self-management engagement (WISE approach to self-care support. Discussion The translation and implementation of a self-care agenda in contemporary health and social context needs to acknowledge and incorporate the resources and networks operating in patients' domestic and social environments and everyday lives. The latter compliments the focus on healthcare settings for developing and delivering self-care support by viewing communities and networks, as well as people suffering from long-term conditions, as a key means of support for managing long-term conditions. By focusing on patient work and social-network provision, our aim is to open up a second frontier in implementation research, to translate knowledge into better chronic illness management, and to shift the emphasis towards support that takes place outside formal health services.
Full Text Available It has been shown that frailty is associated with low levels of wellbeing and life satisfaction. Further exploration is needed, however, to better understand which components constitute life satisfaction for frail older people and how satisfaction is related to other life circumstances. The aim of this study was to examine relationships between frail older people’s life satisfaction and their socioeconomic conditions, social networks, and health-related conditions. A cross-sectional study was conducted (n=179. A logistic regression analysis was performed, including life satisfaction as the dependent variable and 12 items as independent variables. Four of the independent variables made statistically significant contributions: financial situation (OR 3.53, social contacts (OR 2.44, risk of depression (OR 2.26, and selfrated health (OR 2.79. This study demonstrates that financial situation, self-rated health conditions and social networks are important components for frail older people’s life satisfaction. Health and social care professionals and policy makers should consider this knowledge in the care and service for frail older people; and actions that benefit life satisfaction − such as social support − should be promoted.
Verdier, Emilie; Denis, Céline; Bourokba, Nacer; Chauvin, Pierre; Chariot, Patrick
The aim of this study was to describe the health and social conditions of arrestees, as compared to the general population. We studied a sample of 600 adult arrestees in three locations in the Greater Paris area, prospectively included (February-May 2013). A descriptive analysis has been performed, then prevalence was estimated using an indirect standardisation according to age, based on data from a population-based, representative survey in the same area. Arrestees had a median age of 31 years; 92% were males. As compared to the general population, arrestees had a lower level of education (8.6 vs. 7.6%, p analysis of male arrestees and males from the general population showed that the former had worse social and health conditions. These results argue for widespread medical interventions on all arrestees. Medical examination during detention could act as a gateway to health care and social support.
This study employed a multiple case study design to evaluate the perspectives of part-time faculties at three community colleges in the Northeast. The purpose of this study was to discover how needs, working conditions, and social networks influence the part-time faculties' job satisfaction. Maslow (1954), Bourdieu (1986), and Herzberg, Mausner,…
Fritz, Michael; El Rawas, Rana; Klement, Sabine; Kummer, Kai; Mayr, Michael J; Eggart, Vincent; Salti, Ahmad; Bardo, Michael T; Saria, Alois; Zernig, Gerald
A main challenge in the therapy of drug dependent individuals is to help them reactivate interest in non-drug-associated activities. Among these activities, social interaction is doubly important because treatment adherence itself depends on it. We previously developed a rat experimental model based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of social interaction with a gender- and weight-matched male conspecific (i) reversed CPP from cocaine to social interaction despite continuing cocaine training and (ii) prevented the reinstatement of cocaine CPP. In the present study, we investigated if the two subregions of the nucleus accumbens (Acb), i.e., the core (AcbC) and the shell (AcbSh), would differentially affect CPP for cocaine vs social interaction. Animals were concurrently trained for CPP pairing cocaine with one compartment and social interaction with the other (i.e., mutually exclusive stimulus presentation during training). Excitotoxic lesioning of the AcbC or the BLA shifted CPP toward social interaction, whereas AcbSh inactivation shifted CPP toward cocaine. Overall, our findings suggest that inactivation of the AcbC or the BLA is sufficient to shift CPP away from a drug of abuse toward social interaction. Lesioning the AcbSh produced the opposite effect.
de Mendoza, Guillermo; Ventura, Marc; Catalan, Jordi
Aiming to elucidate whether large-scale dispersal factors or environmental species sorting prevail in determining patterns of Trichoptera species composition in mountain lakes, we analyzed the distribution and assembly of the most common Trichoptera (Plectrocnemia laetabilis, Polycentropus flavomaculatus, Drusus rectus, Annitella pyrenaea, and Mystacides azurea) in the mountain lakes of the Pyrenees (Spain, France, Andorra) based on a survey of 82 lakes covering the geographical and environmental extremes of the lake district. Spatial autocorrelation in species composition was determined using Moran's eigenvector maps (MEM). Redundancy analysis (RDA) was applied to explore the influence of MEM variables and in-lake, and catchment environmental variables on Trichoptera assemblages. Variance partitioning analysis (partial RDA) revealed the fraction of species composition variation that could be attributed uniquely to either environmental variability or MEM variables. Finally, the distribution of individual species was analyzed in relation to specific environmental factors using binomial generalized linear models (GLM). Trichoptera assemblages showed spatial structure. However, the most relevant environmental variables in the RDA (i.e., temperature and woody vegetation in-lake catchments) were also related with spatial variables (i.e., altitude and longitude). Partial RDA revealed that the fraction of variation in species composition that was uniquely explained by environmental variability was larger than that uniquely explained by MEM variables. GLM results showed that the distribution of species with longitudinal bias is related to specific environmental factors with geographical trend. The environmental dependence found agrees with the particular traits of each species. We conclude that Trichoptera species distribution and composition in the lakes of the Pyrenees are governed predominantly by local environmental factors, rather than by dispersal constraints. For
Tam, Vivian W Y; Kotrayothar, Duangthidar; Loo, Yew-Chaye
Waste generated from construction and building demolition work constitutes about 68% of all solid waste generated each year in South East Queensland. Consequently, it has created a serious waste management problem. The State Governments of Victoria and New South Wales have been encouraging the use of recycled materials from construction and related waste; they have also promulgated specifications for their use. In Queensland, however, similar regulations are not anticipated in the near future, which explains the lack of funded research conducted in this important arena. This paper presents an evaluation of the prevailing waste recycling practices in Queensland. Nine sites were visited, including two construction sites, three demolition sites, three recycling plants and one landfill in South East Queensland. The difficulties encountered by the recycling programme operators and their associates at these sites are described and the benefits of recycling construction materials are presented. One of the major barriers is that the local councils disallow the use of recycled materials in new construction work. To help rectify these impediments to recycling, recommendations are given to increase the use of recycled construction waste in South East Queensland.
Based on attempts to resolve the problem of various self contradictory assumptions behind the prevailing belief on single photon interference, we have analyzed the process steps behind our experimental measurements and named the process as the Interaction Process Mapping Epistemology (IPM-E). This has helped us recognize that the quantum mechanical Measurement Problem has a much universal and deeper root in nature. Our scientific theorization process suffers from a Perpetual Information Challenge (PIC), which cannot be overcome by elegant and/or sophisticated mathematical theories alone. Iterative imaginative application of IPM-E needs to be used as a metaphorical analytical continuation to fill up the missing information gaps. IPM-E has also guided us to recognize the generic NIW-principle (Non-Interaction of Waves) in the linear domain, not explicitly recognized in current books and literature. Superposition effects become manifest through light-matter interactions. Detecting dipoles gets stimulated by multiple superposed beams; it sums the simultaneous multiple stimulations into a single resultant undulation, which then guides the resultant energy exchange. The consequent transformation in the detector corresponds to observed fringes. They neither represent interference of light; nor represent selective arrival or non-arrival of photons on the detector. Photons do not possess any force of mutual interaction to generate their redistribution. Implementation of IPM-E requires us to recognize our subjective interpretation propensity with which we are burdened due to our evolutionary successes.
Georgiades, Evelina; Klissouras, Vassilis; Baulch, Jamie; Wang, Guan; Pitsiladis, Yannis
While the influence of nature (genes) and nurture (environment) on elite sporting performance remains difficult to precisely determine, the dismissal of either as a contributing factor to performance is unwarranted. It is accepted that a complex interaction of a combination of innumerable factors may mold a talented athlete into a champion. The prevailing view today is that understanding elite human performance will require the deciphering of two major sources of individual differences, genes and the environment. It is widely accepted that superior performers are endowed with a high genetic potential actualised through hard and prodigious effort. Heritability studies using the twin model have provided the basis to disentangle genetic and environmental factors that contribute to complex human traits and have paved the way to the detection of specific genes for elite sport performance. Yet, the heritability for most phenotypes essential to elite human performance is above 50% but below 100%, meaning that the environment is also important. Furthermore, individual differences can potentially also be explained not only by the impact of DNA sequence variation on biology and behaviour, but also by the effects of epigenetic changes which affect phenotype by modifying gene expression. Despite this complexity, the overwhelming and accumulating evidence, amounted through experimental research spanning almost two centuries, tips the balance in favour of nature in the "nature" and "nurture" debate. In other words, truly elite-level athletes are built - but only from those born with innate ability.
Y. I. Portnyagin
Full Text Available An updated empirical climatic zonally averaged prevailing wind model for the upper mesosphere/lower thermosphere (70-110 km, extending from 80°N to 80°S is presented. The model is constructed from the fitting of monthly mean winds from meteor radar and MF radar measurements at more than 40 stations, well distributed over the globe. The height-latitude contour plots of monthly mean zonal and meridional winds for all months of the year, and of annual mean wind, amplitudes and phases of annual and semiannual harmonics of wind variations are analyzed to reveal the main features of the seasonal variation of the global wind structures in the Northern and Southern Hemispheres. Some results of comparison between the ground-based wind models and the space-based models are presented. It is shown that, with the exception of annual mean systematic bias between the zonal winds provided by the ground-based and space-based models, a good agreement between the models is observed. The possible origin of this bias is discussed.
Key words: Meteorology and Atmospheric dynamics (general circulation; middle atmosphere dynamics; thermospheric dynamics
Bond, Jason E; Garrison, Nicole L; Hamilton, Chris A; Godwin, Rebecca L; Hedin, Marshal; Agnarsson, Ingi
Spiders represent an ancient predatory lineage known for their extraordinary biomaterials, including venoms and silks. These adaptations make spiders key arthropod predators in most terrestrial ecosystems. Despite ecological, biomedical, and biomaterial importance, relationships among major spider lineages remain unresolved or poorly supported. Current working hypotheses for a spider "backbone" phylogeny are largely based on morphological evidence, as most molecular markers currently employed are generally inadequate for resolving deeper-level relationships. We present here a phylogenomic analysis of spiders including taxa representing all major spider lineages. Our robust phylogenetic hypothesis recovers some fundamental and uncontroversial spider clades, but rejects the prevailing paradigm of a monophyletic Orbiculariae, the most diverse lineage, containing orb-weaving spiders. Based on our results, the orb web either evolved much earlier than previously hypothesized and is ancestral for a majority of spiders or else it has multiple independent origins, as hypothesized by precladistic authors. Cribellate deinopoid orb weavers that use mechanically adhesive silk are more closely related to a diverse clade of mostly webless spiders than to the araneoid orb-weaving spiders that use adhesive droplet silks. The fundamental shift in our understanding of spider phylogeny proposed here has broad implications for interpreting the evolution of spiders, their remarkable biomaterials, and a key extended phenotype--the spider web. Copyright © 2014 Elsevier Ltd. All rights reserved.
Magzan, Masa Bogojeva
Approaching music from a sociological perspective, this book deals with the concept of ideology in relation to music. The focus of investigation is on the reflection of ideology and power relations in the music curriculum before and after Croatian independence. The goal of this work is to help our understanding of how and why certain musical…
Drapela, Laurie A.; Mosher, Clayton
The effect of parental deviance on adolescent deviance has been a source of considerable debate in the criminological literature. Classic theoretical explanations of the relationships between parental and adolescent deviance posit additive effects of parental deviance on youth behavior. Proponents of the Social Development Model have hypothesized…
Middleton, Hugh; Shaw, Ian
Background: To date debate concerning the relative merits of social and medical sciences has been\\ud largely academic.\\ud Aims: To outline and critically appraise a utilitarian approach to mental health research that reflects a\\ud critical realist perspective.\\ud Method: Consideration of the relative utility of differing approaches to illustrative ‘‘psychiatric’’\\ud disorders, and recent policy initiatives.\\ud Results: Socially relevant outcomes of Bipolar Affective Disorder are determined by...
Yang, Tse-Chuan; Chen, I-Chien; Kim, Seulki; Choi, Seung-Won
Though the adverse consequences of perceived housing discrimination have been documented, little is known about whether such experience undermines one's social capital in a neighborhood and even less is about whether and how this relationship is altered by neighborhood features. We proposed a framework that simultaneously considers within-individual and between-neighborhood processes. We applied multilevel structural equation models to data from Philadelphia (n = 9987) and found that (a) perceived housing discrimination was negatively associated with one's social capital even after other confounders were considered, (b) this negative association could be partly explained by the proliferated daily stress and anxiety mechanisms, (c) differential exposures to neighborhood social disadvantage accounted for the variation in social capital across neighborhoods, and (d) the adverse association between perceived housing discrimination and social capital could be attenuated by neighborhood stability. The findings suggested that appropriate interventions should buffer the negative association of perceived housing discrimination with social capital. Copyright © 2018 Elsevier Inc. All rights reserved.
Full Text Available An earlier study of our research group formulated a conceptual framework of social capital for First Nation communities and developed a culturally appropriate instrument for its measurement. We tested this instrument further with the Manitoba (Canada First Nations Regional Health Survey, 2003. Using data from this survey, we investigated the bonding dimension of the social capital conceptual framework, with a total sample of 2,765 First Nations individuals living in 24 Manitoba First Nations communities. Twenty seven Likert-scale survey questions measured aspects of bonding social capital, socially-invested resources, ethos,and networks. Validation analyses included an evaluation of internal consistency, factor analyses to explore how well the items clustered together into the components of the social capital framework, and the ability of the items to discriminate across the communities represented in the sample. Cronbach’s Alpha was computed on the 27 scale items, producing an Alpha of 0.84 indicating high internal consistency. The factor analyses produced five distinct factors with a total explained variance of 54.3%. Lastly, a one-way analysis of variancerun by community produced highly significant F-ratios between the groups on all twenty-seven bonding items. The culturally-sensitive items included in the social capital framework were found to be an appropriate tool to measure bonding aspects among Manitoba First Nations communities. Research and policy implications are discussed.
Gieswein, Alexander; Hering, Daniel; Feld, Christian K
Freshwater ecosystems are impacted by a range of stressors arising from diverse human-caused land and water uses. Identifying the relative importance of single stressors and understanding how multiple stressors interact and jointly affect biology is crucial for River Basin Management. This study addressed multiple human-induced stressors and their effects on the aquatic flora and fauna based on data from standard WFD monitoring schemes. For altogether 1095 sites within a mountainous catchment, we used 12 stressor variables covering three different stressor groups: riparian land use, physical habitat quality and nutrient enrichment. Twenty-one biological metrics calculated from taxa lists of three organism groups (fish, benthic invertebrates and aquatic macrophytes) served as response variables. Stressor and response variables were subjected to Boosted Regression Tree (BRT) analysis to identify stressor hierarchy and stressor interactions and subsequently to Generalised Linear Regression Modelling (GLM) to quantify the stressors standardised effect size. Our results show that riverine habitat degradation was the dominant stressor group for the river fauna, notably the bed physical habitat structure. Overall, the explained variation in benthic invertebrate metrics was higher than it was in fish and macrophyte metrics. In particular, general integrative (aggregate) metrics such as % Ephemeroptera, Plecoptera and Trichoptera (EPT) taxa performed better than ecological traits (e.g. % feeding types). Overall, additive stressor effects dominated, while significant and meaningful stressor interactions were generally rare and weak. We concluded that given the type of stressor and ecological response variables addressed in this study, river basin managers do not need to bother much about complex stressor interactions, but can focus on the prevailing stressors according to the hierarchy identified. Copyright © 2017 Elsevier B.V. All rights reserved.
Scott, Ryan B; Samaha, Jason; Chrisley, Ron; Dienes, Zoltan
While theories of consciousness differ substantially, the 'conscious access hypothesis', which aligns consciousness with the global accessibility of information across cortical regions, is present in many of the prevailing frameworks. This account holds that consciousness is necessary to integrate information arising from independent functions such as the specialist processing required by different senses. We directly tested this account by evaluating the potential for associative learning between novel pairs of subliminal stimuli presented in different sensory modalities. First, pairs of subliminal stimuli were presented and then their association assessed by examining the ability of the first stimulus to prime classification of the second. In Experiments 1-4 the stimuli were word-pairs consisting of a male name preceding either a creative or uncreative profession. Participants were subliminally exposed to two name-profession pairs where one name was paired with a creative profession and the other an uncreative profession. A supraliminal task followed requiring the timed classification of one of those two professions. The target profession was preceded by either the name with which it had been subliminally paired (concordant) or the alternate name (discordant). Experiment 1 presented stimuli auditorily, Experiment 2 visually, and Experiment 3 presented names auditorily and professions visually. All three experiments revealed the same inverse priming effect with concordant test pairs associated with significantly slower classification judgements. Experiment 4 sought to establish if learning would be more efficient with supraliminal stimuli and found evidence that a different strategy is adopted when stimuli are consciously perceived. Finally, Experiment 5 replicated the unconscious cross-modal association achieved in Experiment 3 utilising non-linguistic stimuli. The results demonstrate the acquisition of novel cross-modal associations between stimuli which are not
La Sorte, Frank A; Fink, Daniel
A number of terrestrial bird species that breed in North America cross the Atlantic Ocean during autumn migration when travelling to their non-breeding grounds in the Caribbean or South America. When conducting oceanic crossings, migratory birds tend to associate with mild or supportive winds, whose speed and direction may change under global warming. The implications of these changes for transoceanic migratory bird populations have not been addressed. We used occurrence information from eBird (1950-2015) to estimate the geographical location of population centres at a daily temporal resolution across the annual cycle for 10 transatlantic migratory bird species. We used this information to estimate the location and timing of autumn migration within the transatlantic flyway. We estimated how prevailing winds are projected to change within the transatlantic flyway during this time using daily wind speed anomalies (1996-2005 and 2091-2100) from 29 Atmosphere-Ocean General Circulation Models implemented under CMIP5. Autumn transatlantic migrants have the potential to encounter strong westerly crosswinds early in their transatlantic journey at intermediate and especially high migration altitudes, strong headwinds at low and intermediate migration altitudes within the Caribbean that increase in strength as the season progresses, and weak tailwinds at intermediate and high migration altitudes east of the Caribbean. The CMIP5 simulations suggest that, during this century, the likelihood of autumn transatlantic migrants encountering strong westerly crosswinds will diminish. As global warming progresses, the need for species to compensate or drift under the influence of strong westerly crosswinds during the initial phase of their autumn transatlantic journey may be diminished. Existing strategies that promote headwind avoidance and tailwind assistance will likely remain valid. Thus, climate change may reduce time and energy requirements and the chance of mortality or
Full Text Available Soil biota effects are increasingly accepted as an important driver of the abundance and distribution of plants. While biogeographical studies on alien invasive plant species have indicated coevolution with soil biota in their native distribution range, it is unknown whether adaptation to soil biota varies among populations within the native distribution range. The question of local adaptation between plants and their soil biota has important implications for conservation of biodiversity and may justify the use of seed material from local provenances in restoration campaigns.We studied soil biota effects in ten populations of the steppe grass Stipa capillata from two distinct regions, Europe and Asia. We tested for local adaptation at two different scales, both within (ca. 10-80 km and between (ca. 3300 km regions, using a reciprocal inoculation experiment in the greenhouse for nine months. Generally, negative soil biota effects were consistent. However, we did not find evidence for local adaptation: both within and between regions, growth of plants in their 'home soil' was not significantly larger relative to that in soil from other, more distant, populations.Our study suggests that negative soil biota effects can prevail in different parts of a plant species' range. Absence of local adaptation points to the possibility of similar rhizosphere biota composition across populations and regions, sufficient gene flow to prevent coevolution, selection in favor of plasticity, or functional redundancy among different soil biota. From the point of view of plant--soil biota interactions, our findings indicate that the current practice of using seeds exclusively from local provenances in ecosystem restoration campaigns may not be justified.
Herd, Pamela; Schaeffer, Nora Cate; DiLoreto, Kerryann; Jacques, Karen; Stevenson, John; Rey, Federico; Roan, Carol
To test the feasibility of collecting and integrating data on the gut microbiome into one of the most comprehensive longitudinal studies of aging and health, the Wisconsin Longitudinal Study (WLS). The long-term goal of this integration is to clarify the contribution of social conditions in shaping the composition of the gut microbiota late in life. Research on the microbiome, which is considered to be of parallel importance to human health as the human genome, has been hindered by human studies with nonrandomly selected samples and with limited data on social conditions over the life course. No existing population-based longitudinal study had collected fecal specimens. Consequently, we created an in-person protocol to collect stool specimens from a subgroup of WLS participants. We collected 429 stool specimens, yielding a 74% response rate and one of the largest human samples to date. The addition of data on the gut microbiome to the WLS-and to other population based longitudinal studies of aging-is feasible, under the right conditions, and can generate innovative research on the relationship between social conditions and the gut microbiome. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: email@example.com.
... comprehensive knowledge or understanding of the subject under study, without specific applications in mind... and investigation in the sciences, social sciences, or humanities. Applied research is research to.... Applied research includes investigations oriented to discovering new scientific knowledge that has...
Bal, Marjolijn I; Sattoe, Jane N T; Miedema, Harald S; van Staa, AnneLoes
Little is known about any differences between young people with chronic physical conditions who do and do not apply for disability benefits in young adulthood for providing insights for future policy and rehabilitation care. We aimed to identify predictors during adolescence of receiving disability benefits in young adulthood and to compare recipients and non-recipients of benefits in social participation and psychosocial outcomes in young adulthood. Follow-up study of 18 to 25 year olds with various chronic conditions who at adolescent age completed a web-based survey (n=518; T0). The outcome was receiving disability benefits (yes or no). Associations with background characteristics, social participation, and impact of the chronic condition were explored with stepwise multivariate modelling, using T0 variables. Differences between recipients and non-recipients were explored using chi-square tests and t-tests. Receiving disability benefits in young adulthood was associated with greater extent of physical disability, receiving less special education, absenteeism at school/work, and low health-related quality of life during adolescence. In young adulthood, recipients of benefits reported higher perceived impact of the chronic condition on their school/work career and lower quality of life than non-recipients. Social participation varied across domains. This study provides important insights into the characteristics of a vulnerable subgroup of young people with chronic physical conditions. Disability benefit recipients experienced more impact of their chronic condition and reported a lower health-related quality of life over time than non-recipients. Rehabilitation professionals are encouraged to use patient-reported outcomes to address the lived experiences and screen the need for psychosocial support of this vulnerable subgroup of young people with chronic physical conditions. Copyright © 2018. Published by Elsevier Masson SAS.
Full Text Available Corporate social responsibility (CSR is becoming an increasingly popular area of activity of companies which are interested in not only the managers or owners, but also customers, suppliers, NGOs, administrative and other stakeholders groups. The analysis aim is to present CSR initiatives as part of deliberate strategy of the company, which is one of the key sources of competitive advantage in the market. The findings concern the scope of cooperation between companies and NGOs in the field of socially responsible activities. The analysis indicates that the expected form of cooperation of NGOs with small businesses is to provide financial assistance to social organizations. However, in the case of medium-sized enterprises, these expectations also apply to material support. Moreover, in the case of medium-sized enterprises a key determinant of cooperation with social organization is realization of the social objective, while small businesses are more guided by "goodness of the heart". Considerations based on the identification of scope of CSR, are pointing to the key aspects of this activity to the company, the environment and customers. Discussions were extended to the characteristics of the benefits, barriers and forms of the cooperation, as well as, there were presented the results of research in the field of forms and determinants of such cooperation. Considerations are based on secondary sources, from national and international journals, books, magazines and specialist reports.
to recognition. In the first part, I outline the normative ideal and show its relevance for practical social work on the basis of social clients' experiences of disrespect. In the second, I expalin the concept of judgement and criticise the prevailing forms of judgement to be found in the social institutions...
Full Text Available Evidence for the effectiveness of patient education programmes in changing individual self-management behaviour is equivocal. More distal elements of personal social relationships and the availability of social capital at the community level may be key to the mobilisation of resources needed for long-term condition self-management to be effective.To determine how the social networks of people with long-term conditions (diabetes and heart disease are associated with health-related outcomes and changes in outcomes over time.Patients with chronic heart disease (CHD or diabetes (n = 300 randomly selected from the disease registers of 19 GP practices in the North West of England. Data on personal social networks collected using a postal questionnaire, alongside face-to-face interviewing. Follow-up at 12 months via postal questionnaire using a self-report grid for network members identified at baseline.Multiple regression analysis of relationships between health status, self-management and health-economics outcomes, and characteristics of patients' social networks.Findings indicated that: (1 social involvement with a wider variety of people and groups supports personal self-management and physical and mental well-being; (2 support work undertaken by personal networks expands in accordance with health needs helping people to cope with their condition; (3 network support substitutes for formal care and can produce substantial saving in traditional health service utilisation costs. Health service costs were significantly (p<0.01 reduced for patients receiving greater levels of illness work through their networks.Support for self-management which achieves desirable policy outcomes should be construed less as an individualised set of actions and behaviour and more as a social network phenomenon. This study shows the need for a greater focus on harnessing and sustaining the capacity of networks and the importance of social involvement with community
Full Text Available A city as a type of a human settlement is characterized by high population density, welldeveloped infrastructure, comfortable living conditions. However, a city is a source of social problems due to high population density, limited resources and conflicts between indigenous population and newcomers. The article analyzes the development of research about the city, provides an assessment of the scope of the historical urban studies in the development of solutions to contemporary problems of urban space. Methodological resource of historical urban studies allows fully exploring the city as a set of historically interconnected spaces and social processes. The analysis of the problem field of historical urban studies at various stages of its formation allowed tracing the evolution of ideas about the city as an object of scientific knowledge, to identify future prospects of research on conditions of Russian urban development, to improve the comfort of living in them.
Batzina, Alkisti; Dalla, Christina; Papadopoulou-Daifoti, Zeta; Karakatsouli, Nafsika
The presence of blue or red-brown substrate on the tank bottom has been previously reported as an efficient means of environmental enrichment for gilthead seabream. The present study aimed to investigate whether this enrichment is still beneficial when gilthead seabream is reared under different social conditions (i.e. a lower 4.9 kg m(-3) and a higher 9.7 kg m(-3) density). Water exchange was adjusted according to fish biomass to exclude density effects on water quality. In the enriched tanks single-colour glass gravel was used as substrate (blue and red-brown substrate, or BS and RBS respectively), while control tanks had no gravel. Growth, aggressive behaviour and size distribution results indicated that the lower density created a less favourable social environment. In both densities studied, BS enhanced growth, suppressed aggression and reduced brain serotonergic activity. In the condition of intense social interactions (i.e. the lower density) BS also reduced brain dopaminergic activity. These results along with the negative correlations observed between brain monoamines and fish body mass, indicated that substrate and density effects are socially-induced. However, there may be several biotic and/or abiotic factors interfering with substrate effects that should be investigated before the practical use of a substrate in land-based intensive aquaculture. Copyright © 2013 Elsevier Inc. All rights reserved.
benzodiazepine drug midazolam (Uvnas-Moberg et al, 1994). A high-stress strain of Sprague-Dawley rats that typically perform poorly on conditioned avoidance...2010). The accurate measurement of fear memory in Pavlovian conditioning : resolving the baseline issue. f Neurosci Methods 190: 235-239. Joordens RJ...stress disorder. Psychiatry Res 48: 107-117. Rescorla RA, Wagner AR (1972). A theory of Pavlovian conditioning : variations in the effectiveness of
Saragih, Dix Wendy
Skripsi ini berjudul The Analysis of American Social Condition in the Middle of Twentieth Century Viewed in Harper Lee’s Novel To Kill A Mockingbird. Yaitu suatu analisis mengenai kondisi sosial masyarakat di Amerika Serikat pada pertengahan abad 20 yang terlihat dalam novel To Kill A Mockingbird karya dari Harper Lee. Dalam analisis ini, penulis menggunakan pendekatan historis mengenai sejarah Amerika pada pertengahan abad keduapuluh. Adapun metode yang digunakan adalah metode deskriptif ...
An immense body of literature has been published on the effects of the residential neighbourhood on individual socio-economic outcomes. Numerous studies have designated these neighbourhood effects to the socialisation and resources mechanisms. This study argues that social contacts and interactions
Full Text Available Este artículo pone de manifiesto las preguntas que le plantea a una perspectiva de género, las nuevas formas de pensar la protección social en la región. Para ello, se toma como ejemplo las transferencias condicionadas de ingresos (TCI puestas en marcha en Chile. Basándose en el ejemplo del programa Puente, la estrategia inicial del sistema de protección social denominado Chile Solidario, el objetivo de este trabajo es analizar cómo estas formas de protección apelan a la participación de las mujeres para salir de la pobreza. Los hallazgos indican que la política de lucha contra la pobreza en Chile se enmarca en una visión multidimensional de la pobreza que, sin embargo, termina posicionando a las mujeres como responsables de lograr el bienestar de todos los miembros de sus hogares. Este artículo concluye proponiendo que el escenario chileno constituye un extremo ejemplo de la extensión de las responsabilidades individuales de las mujeres en la gestión de pobreza, sin proporcionarles ningún componente comunitario o colectivo
Hasson, Shabeh ul; Böhner, Jürgen; Lucarini, Valerio
Largely depending on the meltwater from the Hindukush-Karakoram-Himalaya, withdrawals from the upper Indus Basin (UIB) contribute half of the surface water availability in Pakistan, indispensable for agricultural production systems, industrial and domestic use, and hydropower generation. Despite such importance, a comprehensive assessment of prevailing state of relevant climatic variables determining the water availability is largely missing. Against this background, this study assesses the trends in maximum, minimum and mean temperatures, diurnal temperature range and precipitation from 18 stations (1250-4500 m a.s.l.) for their overlapping period of record (1995-2012) and, separately, from six stations of their long-term record (1961-2012). For this, a Mann-Kendall test on serially independent time series is applied to detect the existence of a trend, while its true slope is estimated using the Sen's slope method. Further, locally identified climatic trends are statistically assessed for their spatial-scale significance within 10 identified subregions of the UIB, and the spatially (field-) significant climatic trends are then qualitatively compared with the trends in discharge out of corresponding subregions. Over the recent period (1995-2012), we find warming and drying of spring (field-significant in March) and increasing early melt season discharge from most of the subregions, likely due to a rapid snowmelt. In stark contrast, most of the subregions feature a field-significant cooling within the monsoon period (particularly in July and September), which coincides well with the main glacier melt season. Hence, a decreasing or weakly increasing discharge is observed from the corresponding subregions during mid- to late melt season (particularly in July). Such tendencies, being largely consistent with the long-term trends (1961-2012), most likely indicate dominance of the nival but suppression of the glacial melt regime, altering overall hydrology of the UIB in
S. U. Hasson
Full Text Available Largely depending on the meltwater from the Hindukush–Karakoram–Himalaya, withdrawals from the upper Indus Basin (UIB contribute half of the surface water availability in Pakistan, indispensable for agricultural production systems, industrial and domestic use, and hydropower generation. Despite such importance, a comprehensive assessment of prevailing state of relevant climatic variables determining the water availability is largely missing. Against this background, this study assesses the trends in maximum, minimum and mean temperatures, diurnal temperature range and precipitation from 18 stations (1250–4500 m a.s.l. for their overlapping period of record (1995–2012 and, separately, from six stations of their long-term record (1961–2012. For this, a Mann–Kendall test on serially independent time series is applied to detect the existence of a trend, while its true slope is estimated using the Sen's slope method. Further, locally identified climatic trends are statistically assessed for their spatial-scale significance within 10 identified subregions of the UIB, and the spatially (field- significant climatic trends are then qualitatively compared with the trends in discharge out of corresponding subregions. Over the recent period (1995–2012, we find warming and drying of spring (field-significant in March and increasing early melt season discharge from most of the subregions, likely due to a rapid snowmelt. In stark contrast, most of the subregions feature a field-significant cooling within the monsoon period (particularly in July and September, which coincides well with the main glacier melt season. Hence, a decreasing or weakly increasing discharge is observed from the corresponding subregions during mid- to late melt season (particularly in July. Such tendencies, being largely consistent with the long-term trends (1961–2012, most likely indicate dominance of the nival but suppression of the glacial melt regime
Buckley, Patrick Henry; Takahashi, Akio; Anderson, Amy
In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building "learning cities" through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal sister city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit Link approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met.
Patrick Henry Buckley
Full Text Available In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building “learning cities” through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal sister city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit Link approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met.
Buckley, Patrick Henry; Takahashi, Akio; Anderson, Amy
In the last half century former international adversaries have become cooperators through networking and knowledge sharing for decision making aimed at improving quality of life and sustainability; nowhere has this been more striking then at the urban level where such activity is seen as a key component in building “learning cities” through the development of social capital. Although mega-cities have been leaders in such efforts, mid-sized cities with lesser resource endowments have striven to follow by focusing on more frugal sister city type exchanges. The underlying thesis of our research is that great value can be derived from city-to-city exchanges through social capital development. However, such a study must differentiate between necessary and sufficient conditions. Past studies assumed necessary conditions were met and immediately jumped to demonstrating the existence of structural relationships by measuring networking while further assuming that the existence of such demonstrated a parallel development of cognitive social capital. Our research addresses this lacuna by stepping back and critically examining these assumptions. To accomplish this goal we use a Proportional Odds Modeling with a Cumulative Logit Link approach to demonstrate the existence of a common latent structure, hence asserting that necessary conditions are met. PMID:26114245
The contribution of housing and neighbourhood conditions to educational inequalities in non-communicable diseases in Europe: findings from the European Social Survey (2014) special module on the social determinants of health.
McNamara, Courtney L; Balaj, Mirza; Thomson, Katie H; Eikemo, Terje A; Bambra, Clare
Social gradients have been found across European populations, where less affluent groups are more often affected by poor housing and neighbourhood conditions. While poor housing and neighbourhood quality have been associated with a range of non-communicable diseases (NCDs), these conditions have rarely been applied to the examination of socioeconomic differences in NCDs. This study therefore asks ‘to what extent does adjusting for poor housing and neighbourhood conditions reduce inequalities in NCDs among men and women in Europe’? Our analysis used pooled-data from 20 European countries for women (n= 12 794) and men (n= 11 974), aged 25–75, from round 7 of the European Social Survey. Fourteen NCDs were investigated: heart/circulatory problems, high blood pressure, back pain, arm/hand pain, foot/leg pain, allergies, breathing problems, stomach/digestion problems, skin conditions, diabetes, severe headaches, cancer, obesity and depression. We used binary logistic regression models, stratified by gender, and adjusted rate ratios to examine whether educational inequalities in NCDs were reduced after controlling for poor housing and neighbourhood quality. Overall, we find that adjusting for poor housing and neighbourhood quality reduces inequalities in NCDs. While reductions were relatively small for some NCDs–for high blood pressure, reductions were found in the range of 0–4.27% among women—for other conditions reductions were more considerable. Controlling for both housing and neighbourhood conditions for example, reduced inequalities by 16–24% for severe headaches and 14–30% for breathing problems. Social gradients in poor housing and neighbourhood quality could be an important contributor to educational inequalities in some NCDs. © The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.
Krantz, G; Ostergren, P O
Over the past few decades there has been a growing interest among researchers, in women's overall life circumstances and their relation to women's health status. For example, paid employment has been considered an important part of women's living conditions in Western societies as the number of women entering the labour market has grown constantly over the past decades. When comparing men's and women's health, one of the most consistent findings is a higher rate of symptoms among women. The most commonly reported symptoms in women are depressive symptoms, symptoms of bodily tension and chronic pain from muscles and joints. The aim of this study was to investigate whether socioeconomic factors, employment status, psychosocial work conditions and social network/support are associated with middle aged women's health status in terms of common symptoms. A mailed questionnaire was used in a cross sectional design assessing socioeconomic factors, employment status, psychosocial work conditions according to the demand/control model, social network/support and an index based on the 15 most frequent symptoms presented by middle aged women when seeking health care. A rural community with 13,200 inhabitants in the western part of Sweden. Women were randomly selected from the general population in the study area, 40 to 50 years of age. The response rate was 81.7 per cent. Women who were non-employed had a significantly increased odds of a high level of common symptoms (OR = 2.82; 95% confidence intervals 1.69, 4.70), as well as women exposed to job strain (OR = 3.27; 1.92, 5.57), independently of the level of social network/support. Furthermore, exposure to low social support, low social anchorage or low social participation independently showed significantly increased odds of a high level of common symptoms (OR = 2.75; 1.71, 4.42; OR = 2.91; 1.81, 4.69 and OR = 1.69; 1.10, 2.61, respectively). Work related factors, such as non-employment and job strain, and circumstances
Background Social inequalities in health are widely examined. But the reasons behind this phenomenon still remain unclear in parts. It is undisputed that the work environment plays a crucial role in this regard. However, the contribution of psychosocial factors at work is unclear and inconsistent, and most studies are limited with regard to work factors and health outcomes. This study, therefore, aimed to explore the role and contribution of various physical and psychosocial working conditions to explaining social inequalities in different self-reported health outcomes. Methods Data from a postal survey among the workforces of four medium-sized and large companies from diverse industries of the secondary sector in Switzerland were used and analysed. The study sample covered 1,846 employees aged 20 and 64 and included significant proportions of unskilled manual workers and highly qualified non-manual workers. Cross tabulations and logistic regression analyses were performed to study multiple associations between social status, work factors and health outcomes. Combinations of educational level and occupational position wee used as a measure of social status or class. Results Clear social gradients were observed for almost all adverse working conditions and poor health outcomes studied, but in different directions. While physical workloads and other typical blue-collar job characteristics not suprisingly, were found to be much more common among the lower classes, most psychosocial work demands and job resources were more prevalent in the higher classes. Furthermore, workers in lower classes, i.e. with lower educational and occupational status, were more likely to report poor self-rated health, limited physical functioning and long sickness absence, but at the same time were less likely to experience increased stress feelings and burnout symptoms showing a reversed health gradient. Finally, blue-collar job characteristics contributed substantially to the social
Full Text Available The European Union is often considered as a prime example of a liberal regulatory state. We argue, however, that being limited to the regulatory policy does not prevent the European Commission from pursuing political aims going beyond market efficiency. We draw up two ideal-type perspectives of market regulation – being either efficiency or equality enhancing – that differ systematically in terms of rationale, degree of intervention, patterns of stakeholder access and conflict within the regulator. We trace these aspects in three financial services initiatives on the registration and supervision of reinsurers, equal treatment in financial services and the regulation of consumer credit. Our analyses suggest that there is scope for equality-enhancing re-regulation when proactive agents proceed decidedly on the basis of social-treaty concerns and frame regulatory beneficiaries as market participants as well as when they seek the redistribution of rights instead of resources.
Full Text Available In a Sahelian environment, the concession is a common, social, but also complex organization. An example is provided by dairy products management in pastoral and agropastoral environments. A schema of the social and zootechnical organization of such management was developed based on field work concerning farmers living in the Senegal River delta. Milking is a crucial step of milk management. It helps to shape the “milk sphere”, which contains both livestock and people who drive them. The proposed model distinguished different decision making levels: that of milkers/farmers who decided on milked quantities (production, and that of women collectors who decided individually if milked milk was for self-consumption, trade or gift. Besides, the present model helped avoid the common trap of confusing herd manager or concession head with dairy farm head.
Aragon-Ching, Jeanny B
PREVAIL was a phase III multinational, double-blind, placebo-controlled trial that enrolled chemotherapy-naïve men with metastatic castration-resistant prostate cancer (mCRPC), which showed remarkable improvement in co-primary endpoints with an overall 81% reduction in the risk of radiographic progression, as well as 29% reduction in the risk of death in favor of the enzalutamide arm over placebo. All secondary endpoints including time to subsequent chemotherapy initiation and prostate specific antigen (PSA) progression were in favor of the enzalutamide arm. The results of PREVAIL shows the utility of enzalutamide that would likely soon expand the indication to asymptomatic or minimally symptomatic men with mCRPC not previously treated with chemotherapy.
Aro, A R; Pilvikki Absetz, S; van Elderen, T M
-ups at 2 and 12 months postscreening. At 2 months, there was a moderate multivariate effect of group on distress; and intrusive thinking and worry about breast cancer, in particular, were most frequent amongst the false positives. Intrusive thinking still prevailed at 12 months, in addition to a higher...... findings (n=1407), false-positive findings (n=492) and referents from outside the screening programme (n=1718, age 48-49 years). Distress was measured as illness worry, anxiety, depression, cancer beliefs and early detection behaviour. Measurements were one month before screening invitation with follow...... perceived breast cancer risk and susceptibility. Distress related to screening and false-positive findings seems to be moderate, but prevailing cancer-specific concerns call for improvements in screening programmes....
Kreager, Derek A; Young, Jacob T N; Haynie, Dana L; Bouchard, Martin; Schaefer, David R; Zajac, Gary
Research of inmate social order is a once-vibrant area that receded just as American incarceration rates climbed and the country's carceral contexts dramatically changed. This study reengages inmate society with an abductive mixed methods investigation of informal status within a contemporary men's prison unit. The authors collect narrative and social network data from 133 male inmates housed in a unit of a Pennsylvania medium-security prison. Analyses of inmate narratives suggest that unit "old heads" provide collective goods in the form of mentoring and role modeling that foster a positive and stable peer environment. This hypothesis is then tested with Exponential Random Graph Models (ERGMs) of peer nomination data. The ERGM results complement the qualitative analysis and suggest that older inmates and those who have been on the unit longer are perceived by their peers as powerful and influential. Both analytical strategies point to the maturity of aging and the acquisition of local knowledge as important for attaining informal status in the unit. In sum, this mixed methods case study extends theoretical insights of classic prison ethnographies, adds quantifiable results capable of future replication, and points to a growing population of older inmates as important for contemporary prison social organization.
Aro, A R; Pilvikki Absetz, S; van Elderen, T M
The aim of this study was to examine psychological distress in a mammography screening process as a consequence of screening after adjusting for background, personality and prescreening distress. Subjects, aged 50 years, were invitees at their first screening. There were three groups; normal find...... perceived breast cancer risk and susceptibility. Distress related to screening and false-positive findings seems to be moderate, but prevailing cancer-specific concerns call for improvements in screening programmes....
The influence of early formed dietary practices on food choices and preferences during adulthood has often been assumed but rarely adequately demonstrated given the difficulty of studying the subject matter with conventional laboratory or observational research designs. This article examines this assumption by analyzing the information from 31 structured interviews on the respondents' current preferences for combinations of six side dishes with bread or mămăligă (boiled cornmeal mush, similar to polenta). All the respondents had consumed mămăligă in their childhood but in their adulthood had switched to bread following the social and economic upheavals from 1960s Romania. The results show that a) for specific combinations, physiological factors and/or cultural norms that defined bread as a 'prestigious' food have been capable of overriding the effects of early socialization with mămăligă as the accompanying food and b) that consumers continue to prefer certain side dishes with mămăligă even after decades of predominant consumption of bread although confounding factors might account for such preferences. These findings qualify the expectation that an early familiarization with healthy eating habits will promote this desired lifestyle during adulthood by showing that physiological and socio-cultural factors are capable of overriding its effects on hedonic preferences. Copyright © 2016 Elsevier Ltd. All rights reserved.
Melloul, Abraham J; Collin, Martin L
This study focuses on the problem of most efficiently fulfilling the water requirements of society for sustainable water resources management. The goal is to coordinate effectively the social needs of the resident population with operational water resources management planning.The proposed approach consists of a pyramidal hierarchy of water resource management needs, similar to that suggested by psychologist Abraham Maslow for human social needs. The two pyramidal hierarchies can be simultaneously employed to delineate guidelines to synchronize planning for sustainable water resources development with the concerns and expectations of the resident population. In both hierarchies, higher level needs remain irrelevant and difficult to attain until lower level needs of the resident population have been fulfilled. Management planning measures employed with regard to Israel's coastal aquifer have been used to illustrate this approach. Observation of Israel's experience indicates markedly reduced effectiveness where such measures have failed to be properly synchronised with societal needs. Conversely, where hydrological management measures were successfully synchronized with societal concerns, increased efficiency towards attaining sustainable groundwater management was evident.
Vsevolod Petrovich Babushkin
Full Text Available In the article, the transport role in the decision of problems of innovative and scientifically-technological development of territory is defined. Dependence of quality, completeness and timeliness of granting of transport services on replenishment and updating of park of locomotives, cars, i.e. from a level of development of domestic transport mechanical engineering is shown. The basic problems of development given branches –low competitiveness of made production are revealed. The basic accent in the course of such analysis is made on research of competitive possibilities of the enterprises of railway mechanical engineering of Sverdlovsk area. Such enterprises play the increasing role, become points of development of region’s economy and maintenance of its social and economic safety. The cooperation communications, which have developed in an industrial complex of Sverdlovsk area on the basis of development of modern manufacture on building of electric locomotives, have allowed to generate in region cluster railway mechanical engineering. The structure cluster is shown, development prospects, the estimation of its influence on the economy of Sverdlovsk area and maintenance of its social and economic security is given
Cohen-Vogel, Lora; Goldring, Ellen; Smrekar, Claire
By using Geographic Information System (GIS) mapping software to combine health and crime data with data from 20 schools in one Southeastern district, the study explores whether and how neighborhood conditions affect school-community arrangements. Findings show that the nature of the relationships and the strategies principals and teachers use to…
Jaganathan, Mathivannan; Mustapa, Azrain Nasyrah; Hasan, Wan Azlina Wan; Mat, Nik Kamariah Nik; Alekam, Jamal Mohammed Esmail
It is an undeniable fact that penetration level and usage and sales of Smartphone dramatically increased past few years, whereby; it has increased to almost 60 percent of total population. Despite the high penetration of smartphone, previous studies have exhibited inconsistent findings towards understanding the behavioural intention to use smartphone especially among university students. Thus, the purpose of this study is to examine purchasing behaviour of Smartphone among students. From the literature, five antecedents of purchasing behaviour were identified. Each variable is measured using 7-point Likert scale: convenience (10 items), social influence (6 items), self-efficacy (10 items), facilitating condition (11 items), dependency (14 items) and purchasing behaviour (4 items). Using the primary data collection method, 400 questionnaires were distributed to the target respondents of one of the public higher education in the northern region. The responses collected were 350 completed questionnaires representing 87.5 percent response rate. The data were analysed using Structural Equation Modeling (SEM) using AMOS. Confirmatory factor analysis of measurement models indicates adequate goodness or fit after few items were eliminated through modification indices verifications. Therefore, goodness of fit for the generated structural model shows the adequate fit. This study has established four direct significant causal effects and two significant mediating effects: (1) convenience and dependency, (2) social influence and dependency, (3) facilitating condition and purchase behaviour, (4), dependency and purchase behaviour. The significant mediating results are: (1). Dependency mediates the relationship between convenience and purchase behaviour; (2) dependency mediates social influence and purchase behaviour. Thus, findings suggested that convenience, social influence and dependency play a role in determining students purchase behaviour of smartphone. The researchers
Cocca, Aldo Armando
Men may do many things, but they must never forget the human condition in any act or relation with a fellow human being. Space Law has vindicated the supreme value of man as a legal subject par excellence. The dignity of the human being is a value that rates above any scientific or technological advance. A benefit, by definition and derivation, is anything contributing to an improvement in a condition. Social benefits pertain only to human beings, who are their sole beneficiaries. Developing countries are young nations that through their international relations may, and indeed must, realize the benefits of space technology. The principle of the "common heritage of Mankind" was created to satisfy the aspirations of all peoples and to meet the needs of both industrialized and developing countries. Only a groundless fear and lack of vision of the future can induce governments to delay its implementation. We must not forget that the concept was transformed into a principle of international positive law by the unanimous decision of the international community, which enshrined it in the Moon Agreement. The social and individual responsibility of the scientist is becoming even more clearly defined, and scientists play an important role in the conduct of nations. Through education, including education in the humanities and a graduation pledge, the scientist has embarked on the road leading to an active presence in society, facing his responsibility. Inter-generational equity contributes to strengthening the concept of the human condition and the legal principle of the common heritage of mankind.
Full Text Available An Early childhood dance program is a way to open the door to social competence, tradition learning and cultural integration besides achieving motor skills. The past few decades have demonstrated that dance education and the use of symbolic movement in early childhood, greatly enhance young children's learning. While a great amount of attention has been devoted to understanding how a variety of learning modes function in young children, an understanding of the benefits of dance education has not received strong recognition in the equation . I suggest that movement and dance are the first communicative "language" that enables learning. Creating new contexts in and through dance for learning offers young children opportunities to understand and negotiate their community and the surrounding world.DANSUL CA CONDIŢIE ÎN FORMAREA COMPETENŢELOR SOCIALE, TRADIŢIONALE ŞI CULTURALE ÎN PERIOADA COPILĂRIEI TIMPURII Un program de dans specific copilăriei timpurii, pe lângă faptul că dezvoltă abilităţile motorii, este o modalitate de a forma competenţe sociale prin învăţarea tradiţiilor şi de integrare culturală. Ultimele decade au demonstrat că educaţia prin dans şi utilizarea mişcărilor simbolice în copilăria timpurie au un impact pozitiv asupra învăţării. În timp ce o mare parte de atenţie a fost acordată înţelegerii funcţionării variabilelor moduri de învăţare la copii, înţelegerea beneficiilor educaţiei prin dans nu s-a bucurat de aceeaşi recunoaştere din partea cercetătorilor. Sugerăm că mişcarea şi dansul sunt primele limbaje de comunicare care autorizează învăţarea. Crearea noilor contexte în şi prin dans oferă copiilor oportunităţi de a înţelege şi a negocia atât în cadrul comunităţii lor, cât şi în afara acesteia.
Mukhambetov, D.G.; Kargin, D.B.; Chalaya, O. V.; Berber, N.N.
It is known, that the kinetics of oxidation of zirconium at formed heating is characterized by two consecutive stages. At the initial stage the thin protecting film will be derived. The relation of its depth from time h (t) is described predominantly by parabolic law. Some time later there can be a transition to the linear law of oxidation. The time moment divided these areas on the kinetic relation is called as a point of break. The film is formed at the second stage, has a developed grid of pores or cracks, can be flake away and be crumbled by losing its protective properties. At the oxidation of the surface shells of the heat generating elements and the technological channels of atomic boilers both stages are proceeded simultaneously. This phenomenon is called modular corrosion. Its consequences can be dangerous for the equipment. Its mechanism is not clear till now. Similar dependencies h(t), with the break point, beginning from which the thin film is transformed into the thick one were found by us at the oxidation α-Fe with prevailing cubical texture. The task of the work was to study the oxide film growth laws in order to clarify the mechanisms of transition of the thin film into the oxide layer on the α-Fe surface and Zr-Nb alloy modular corrosion emergence. Low-carbonate steel with contents 99.43 % of α-Fe was used as a model object of our research. In the texture of the steel surface planar direction  was prevalent. Its part accounted for about 40 %. The isothermal air oxidation was carried out in the interval of 450-500 deg. C . Phase composition of the film was determined with X-ray diffraction. The mathematical treatment of the dependencies h(t) obtained by experiment showed that the kinetics of the film growth can be conditionally divided into 4-stages. The initial stage is described by function logarithmic function, the other stages - by the power mode h n =A n ·t, namely, the second stage - is described by function close to cubical (n≅3
Santiago, Jose H; Tarantino, Santo J
This study examined the validity of the view that the constructs of individualism and collectivism are coherent cultural manifestations necessarily reflected in an individual's attribution patterns. It was hypothesized that the attribution patterns of locus of control and moral accountability would show divergent individualistic and collectivistic influences in a culture during change from a collectivist culture to an individualist culture. 98 university students from the United States and Puerto Rico were administered the Singelis Individualism-Collectivism Scale, Rotter's Locus of Control Scale, and Miller and Luthar's justice-related moral accountability vignettes. Contrary to expectation, the Puerto Rican sample scored less external in locus of control than the United States sample. No cultural differences in moral accountability were found. No strong correlations were found among the variables at the individual level of analysis. Accounting for these results included the lack of representativeness of the samples, the independence of relation between variables at different levels of analysis, and social change.
Full Text Available This study is carried out in chacthment area of Bodri. The goals of this study are to kno the influence of economic social condition of population on the change of the kind of landuse and the influence of the change of the kind of landuse on the run-off area. This study uses survey method. The collected data are the economic social data of the population and the physical condition data in the research area. The result of the study shows that the economic social condition of the population in chatchment area of Bodri influences on the decrease of landuse. The decrease in landuse is 22.27% which used settlement, dry land cultivation (3.14%, yard (1.07%, plantation (0.44%, wet land cultivation (2.28%, embankment (0.25%, street and others (6.73%. The decrease in landuse causes peak discharge of Hydrograph in 1997, 1999, 2000, and 2001 increases respectively 87.32 m/second, 101.26 m/second, 58.37 m/second, 89.82 m/second, with each volume of direct flow 7.123.392 m, 6.011.604 m, 11.784.672 m, and 9.459.954 m. The run-off coefficient in 1992, 1997, 1999, 2000, and 2001 increase 7.7%, 13%, 19.8%, 23.2%, and 27.03%, with coefficient of annual flow 46.98%, 72%, 55.21%, 61,79%, and 75.55%. The increasing of the run-off coeficient and annual flow describes that the ratio both the discharge of maximum and minimum monthly flow becomes bigger. It means that in rainy season it will be flood immediately and in dry season it will be drought easily.
Full Text Available Cities are key for sustainability and the radical systemic changes required to enable equitable human development within planetary boundaries. Their particular role in this regard has become the subject of an emerging and highly interdisciplinary scientific debate. Drawing on a qualitative literature review, this paper identifies and scrutinizes the principal fields involved, asking for their respective normative orientation, interdisciplinary constitution, theories and methods used, and empirical basis to provide orientations for future research. It recognizes four salient research epistemologies, each focusing on a distinct combination of drivers of change: (A transforming urban metabolisms and political ecologies; (B configuring urban innovation systems for green economies; (C building adaptive urban communities and ecosystems; and (D empowering urban grassroots niches and social innovation. The findings suggest that future research directed at cities and systemic change towards sustainability should (1 explore interrelations between the above epistemologies, using relational geography and governance theory as boundary areas; (2 conceive of cities as places shaped by and shaping interactions between multiple socio-technical and social-ecological systems; (3 focus on agency across systems and drivers of change, and develop corresponding approaches for intervention and experimentation; and (4 rebalance the empirical basis and methods employed, strengthening transdisciplinarity in particular.
2005/2006 Serena Fedel's dissertation is focused on gender issues, more precisely she has chosen to analyse the social conditions of employed women and the way they manage to reconcile the duties arising from their job with the ones connected with their role within the family. Geographically speaking she has decided to examine the above mentioned issues in the core of the so called Alps-Adriatic region, i.e. in the three bordering areas of Carinthia, Friuli Venezia Giulia and Slovenia. ...
Benach, Joan; Muntaner, Carles; Solar, Orielle; Santana, Vilma; Quinlan, Michael
Although the conditions and power relations of employment are known to be crucial health determinants for workers and their families, the nature of these relations and their effects on health have yet to be fully researched. Several types of employment--precarious employment in developed countries; informal sectors, child labor, slavery, and bonded labor in developing countries--expose workers to risky working conditions. Hazardous work and occupation-related diseases kill approximately 1,500 workers, globally, every day. Growing scientific evidence suggests that particular employment conditions, such as job insecurity and precarious employment, create adverse health effects; yet the limited number of studies and the poor quality of their methods prevent our understanding, globally, the complexity of employer-employee power relations, working conditions, levels of social protections, and the reality of employment-related health inequalities. This article introduces a special section on employment-related health inequalities, derived from the EMCONET approach, which focuses on (1) describing major methods and sources of information; (2) presenting theoretical models at the micro and macro levels; (3) presenting a typology of labor markets and welfare states worldwide; (4) describing the main findings in employment policies, including four key points for implementing strategies; and (5) suggesting new research developments, a policy agenda, and recommendations. This introduction includes a glossary of terms in the emerging area of employment conditions and health inequalities.
/ Managing protected areas involves balancing the enjoyment of visitors with the protection of a variety of cultural and biophysical resources. Tourism pressures in the Great Barrier Reef World Heritage Area (GBRWHA) are creating concerns about how to strike this balance in a marine environment. Terrestrial-based research has led to conceptual planning and management frameworks that address issues of human use and resource protection. The limits of acceptable change (LAC) framework was used as a conceptual basis for a study of snorkeling at reef sites in the GBRWHA. The intent was to determine if different settings existed among tourism operators traveling to the reef and, if so, to identify specific conditions relating to those settings. Snorkelers (N = 1475) traveling with tourism operations of different sizes who traveled to different sites completed surveys. Results indicated that snorkelers who traveled with larger operations (more people and infrastructure) differed from those traveling with smaller operations (few people and little on-site infrastructure) on benefits received and in the way that specific conditions influenced their enjoyment. Benefits related to nature, escape, and family helped to define reef experiences. Conditions related to coral, fish, and operator staff had a positive influence on the enjoyment of most visitors but, number of people on the trip and site infrastructure may have the greatest potential as setting indicators. Data support the potential usefulness of visitor input in applying the LAC concept to a marine environment where tourism and recreational uses are rapidly changing.
Basu, Sukanta; Nunalee, Christopher G.; He, Ping; Fiorino, Steven T.; Vorontsov, Mikhail A.
In this paper, we reconstruct the meteorological and optical environment during the time of Titanic's disaster utilizing a state-of-the-art meteorological model, a ray-tracing code, and a unique public-domain dataset called the Twentieth Century Global Reanalysis. With high fidelity, our simulation captured the occurrence of an unusually high Arctic pressure system over the disaster site with calm wind. It also reproduced the movement of a polar cold front through the region bringing a rapid drop in air temperature. The simulated results also suggest that unusual meteorological conditions persisted several hours prior to the Titanic disaster which contributed to super-refraction and intermittent optical turbulence. However, according to the simulations, such anomalous conditions were not present at the time of the collision of Titanic with an iceberg.
Gountas, Sandra; Gountas, John
Much research focuses on organizational culture and its impact on customer orientation or emotional states and their impact on job satisfaction and well-being. This study aims to combine the complex roles of nurses' emotion states and job satisfaction in a model that identifies the effects of standards for service delivery (organizational culture), supervisor and co-worker support and the development of customer orientation. A previous study examined the relationships between nurses' personal resources, job satisfaction and customer orientation. This study examines how these variables relate to organizational standards and social support. A cross-sectional survey using a self-completion questionnaire with validated, existing scales to measure standards for service delivery, supervisor and co-worker support, job satisfaction, empathic concern, emotional exhaustion and customer orientation. Nurses (159) completed the questionnaire in 2010. The data were analysed using WarpPLS, a structural equation modelling software package. The results indicate that the final model fits the data well and explains 84% of the variance in customer orientation. The findings show the importance of standard for service delivery (organizational culture), supervisor and co-worker support on customer orientation. Nurses' personal resources interact with these, particularly supervisor and co-worker support, to develop staff job satisfaction and empathy. The need for support mechanisms in stressful times is discussed. We propose that training in compassion and empathy would help leaders to model desirable attributes that contribute towards customer orientation. © 2015 John Wiley & Sons Ltd.
Landau, Mark J.; Meier, Brian P.; Keefer, Lucas A.
Social cognition is the scientific study of the cognitive events underlying social thought and attitudes. Currently, the field's prevailing theoretical perspectives are the traditional schema view and embodied cognition theories. Despite important differences, these perspectives share the seemingly uncontroversial notion that people interpret and…
Schneier, F R; Foose, T E; Hasin, D S; Heimberg, R G; Liu, S-M; Grant, B F; Blanco, C
To assess the prevalence and clinical impact of co-morbid social anxiety disorder (SAD) and alcohol use disorders (AUD, i.e. alcohol abuse and alcohol dependence) in a nationally representative sample of adults in the United States. Data came from a large representative sample of the US population. Face-to-face interviews of 43093 adults residing in households were conducted during 2001-2002. Diagnoses of mood, anxiety, alcohol and drug use disorders and personality disorders were based on the Alcohol Use Disorder and Associated Disabilities Interview Schedule - DSM-IV version. Lifetime prevalence of co-morbid AUD and SAD in the general population was 2.4%. SAD was associated with significantly increased rates of alcohol dependence [odds ratio (OR) 2.8] and alcohol abuse (OR 1.2). Among respondents with alcohol dependence, SAD was associated with significantly more mood, anxiety, psychotic and personality disorders. Among respondents with SAD, alcohol dependence and abuse were most strongly associated with more substance use disorders, pathological gambling and antisocial personality disorders. SAD occurred before alcohol dependence in 79.7% of co-morbid cases, but co-morbidity status did not influence age of onset for either disorder. Co-morbid SAD was associated with increased severity of alcohol dependence and abuse. Respondents with co-morbid SAD and alcohol dependence or abuse reported low rates of treatment-seeking. Co-morbid lifetime AUD and SAD is a prevalent dual diagnosis, associated with substantial rates of additional co-morbidity, but remaining largely untreated. Future research should clarify the etiology of this co-morbid presentation to better identify effective means of intervention.
Butler, Danielle C; Thurecht, Linc; Brown, Laurie; Konings, Paul
Recent Australian policy initiatives regarding primary health care focus on planning services around community needs and delivering these at the local area. As in many other countries, there has also been a growing concern over social inequities in health outcomes. The aims of the analysis presented here were firstly to describe small area variations in hospital admissions for ambulatory care sensitive conditions (ACSC) among children aged 0-4 years between 2003 and 2009 in the state of Victoria, Australia, and secondly to explore the relationship of ACSC hospitalisations with socio-economic disadvantage using a comparative analysis of the Child Social Exclusion (CSE) index and the Composite Score of Deprivation (CSD). This is a cross sectional secondary data analysis, with data sourced from 2003 to 2009 ACSC data from the Victorian State Government Department of Health; the Australian Standard Geographical Classification of remoteness; the Australian 2006 Census of Population and Housing; and AMPCo General Practitioner data from 2010. The relationship between the indexes and child health outcomes was examined through bivariate analysis and visually through a series of maps. The results show there is significant variation in the geographical distribution of the relationship between ACSCs and socio-economic disadvantage, with both indexes capturing important social gradients in child health conditions. However, measures of access, such as geographical accessibility and workforce supply, detect additional small area variation in child health outcomes. This research has important implications for future primary health care policy and planning of services, as these findings confirm that not all areas are the same in terms of health outcomes, and there may be benefit in tailoring mechanisms for identifying areas of need depending on the outcome intended to be affected. Copyright © 2013 Elsevier Ltd. All rights reserved.
This dissertation focuses on wind energy for electricity generation, analysing the evolution of the wind power supply market in the Netherlands. We analysed different kind of wind power entrepreneurs (energy distributors, small private investors, wind cooperatives and new independent wind power producers), their capacity to implement wind energy and the social and institutional conditions that affected their investments over the period 1989-2004. Central in the analyses are the institutional regulatory dimension and the social context as explanatory variables for the emergence and performance of these wind power entrepreneurs. Special attention is given to the liberalisation of the electricity market. The primary social actors for the implementation of wind energy projects in a liberalised market are entrepreneurs willing to invest. Understanding conditions that trigger entrepreneurs to invest in these projects, and understanding conditions that determine the chance of success for entrepreneurs to implement and exploit their projects, is vital for setting up effective policies to stimulate wind electricity generation. The analytical perspective that we used to study investment behaviour of wind power entrepreneurs and their capacity to implement wind energy can be referred to as the 'new institutional perspective'. Based on this new institutional perspective the concept of implementation capacity has been developed. Implementation capacity indicates the feasibility for wind power entrepreneurs to adopt wind turbines, and enables to explain, comparatively, changing possibilities in time for different types of entrepreneurs. The development of the wind power supply market is divided into three successive market periods: Monopoly powers (1989-1995), Interbellum (1996-1997) and Free market (1998-2002). We conducted case studies on the implementation capacity of the four entrepreneurial groups in each of the three market periods. The case studies led to conclusions
Das, Koyeli; Roy, Milan Chandra; Rajbanshi, Biplab; Roy, Mahendra Nath
Qualitative and quantitative analysis of molecular interaction prevailing in tyrosine and tryptophan in aqueous solution of vitamin C have been probed by thermophysical properties. The apparent molar volume (ϕV), viscosity B-coefficient, molal refraction (RM) of tyrosine and tryptophan have been studied in aqueous vitamin C solutions at diverse temperatures via Masson equation which deduced solute-solvent and solute-solute interactions, respectively. Spectroscopic study along with physicochemical and computational techniques provides lots of interesting and highly significant insights of the model biological systems. The overall results established strong solute-solvent interactions between studied amino acids and vitamin C mixture in the ternary solutions.
Vanderlei dos Santos
Full Text Available The study aims to identify the types of analysis of Trompenaar's (1994 organizational culture prevailing in the area of controllership in family businesses in textile industry. Descriptive research was performed, with quantitative and qualitative approach, using a multiple case study. Data were collected through interviews with the controller of the companies. In the four basic culture types suggested by Trompenaars (1994, it is concluded that there isn´t a pure kind, but there is a strong presence of family culture among the companies surveyed in dimensions relationship between employees, attitude in relation to the ways of change, forms of motivation and reward
Full Text Available Seen as a psycho-social products, motivation, attitudes and the view of life depends on the education, socio-cultural environment etc. The individual’s personality marks his activities, motivations and interests, as it ensures the direction and dynamics of the participation to it. Within the group, the individual seeks to satisfy personal needs, in agreement with the achievement of the organizational goals. The level of motivation of the individual is determined by the action of several factors, and the contribution of each member of the group's performance is different. We aim to assess the level of motivation of the members of sports groups. The research sample was composed of athletes (N=158, 55 females, 103 males from the sports groups within the city of Iasi, part of the first and second sports divisions (basketball, football, handball, rugby, and volleyball. The respondents answered to a adapted to the Romanian population 32-item questionnaire; the items were grouped into four factors: leadership (power needs, expertise / performance (achievement needs, bonding (affiliation needs, subsistence (existence needs. The homogeneity instrument was assessed for the entire scale, as well as independently for each factor. The lack of variance homogeneity made it impossible to get outcomes for the interaction of the independent variables such as the type of club and the status. No gender-based differences were found regarding the power needs. If the type of club does not influence the expert/performance factor, have identified a partial influences of this variable over the bonding factor. Professional athletes are more motivated to achieve the performance than semi professional athletes.
McGuinness, Charles Lee
the socioeconomic facts necessary to intelligent social actions involving water.
Gustafsson, Klas; Aronsson, Gunnar; Marklund, Staffan; Wikman, Anders; Hagman, Maud; Floderus, Birgitta
Disability pension has increased in recent decades and is seen as a public health and socioeconomic problem in Western Europe. In the Nordic countries, the increase has been particularly steep among young women. The aim was to analyze the influence of low social integration, socioeconomic risk conditions and different measures of self-reported ill health on the risk of receiving disability pension in young women. The study comprised all Swedish women born in 1960 to 1979, who had been interviewed in any of the annual Swedish Surveys of Living Conditions (1990-2002). The assumed predictors were related to disability pension by Cox proportional hazard regression. The mean number of years of follow-up for the 10,936 women was 7 years (SD 3.8), and the study base was restricted to the ages 16 to 43 years of age. An increased risk of receiving a disability pension was found among lone women, those who had sparse contacts with others, job-seeking women, homemakers, as well as women with low education, and poor private financial situations. A tenfold increase in the risk of receiving a disability pension was found among women reporting a long-standing illness and poor self-rated health, compared to women without a long-standing illness and good self-rated health. Psychiatric diagnoses and symptoms/unspecified illness were the strongest predictors of disability pension, particularly before 30 years of age. The study suggests that weak social relations and weak connections to working life contribute to increase the risk of disability pension in young women, also after control for socioeconomic conditions and self-reported ill health. Self-rated health was the strongest predictor, followed by long-standing illness and not having a job (job seekers and homemakers).
Full Text Available The relevance of the problem under study is due to the society's requirements for the quality information training of a personality which is oriented to forming the solid fundamental knowledge as well as to developing the cognitive capacities that are needed for solving mental tasks. With regard to this, the paper is aimed at finding out the opportunities of applying the natural tools in information training of students from the standpoints of embodied and mental approaches. The main idea of these is integrated studying of an object, beginning with learning it in an "embodied" way and finishing with abstract models formed in the human memory. The leading approach to the research is the integrated one taking into account the psychological and pedagogical, didactic and methodological constituents. It allows identifying the psychological and pedagogical conditions of application of natural tools as well as the possible ways of their use. The authors describe models of natural tools of computer science training in individual sections of the school course as the main results. The materials of the paper are of practical value in methods of teaching computer science to students at various stages of education.
Le Blanc, M; McDuff, P; Tremblay, R E
Available data on the impact of certain types of families is lacking, and the results are often misleading with respect to maladjustment. Following a description of variations in delinquent activity and behaviour problems according to family type, the authors analyse the difficulties in the operation of family systems. Comparisons of six family types apply to data from 763 boys aged 10, 319 female and 426 male adolescents, aged 14 and 15: intact families, father-based and mother-based single-parent families, father-based and mother-based reconstituted families and substitute families. The article's data show that in the late eighties, nearly 40 per cent of children and adolescents living in low-income districts in Montreal belonged to disunited families. In addition, the data confirm a classic observation: in comparison with intact families, disunited families are underprivileged in relation to living conditions, deficient in relation to psychosocial functioning, and propitious to behaviour problems and delinquent activity. In addition, it has been established that certain disunited family types represent a considerable risk factor. The damaging effect of family structure increases in the following order: intact families, mother-based single-parent families, mother-based reconstituted families, substitute families, father-based reconstituted families and father-based single-parent families. Finally, certain intervention methods are suggested to help prevent behaviour and family problems.
Kaneko, Korehisa; Matsushima, Hajime
Chiba Prefecture, Japan, lies very near Tokyo, the capital city of Japan. It borders the sea on three sides and is banded by coastal dunes. Several sake breweries are located near these dunes. Although there are records of sake brewing along the coast of Tokyo Bay since 1925, sake breweries have completely disappeared in several areas. We believe that sake brewing in these areas benefited from the ecosystem services afforded them by their proximity to the coastal ecosystem. We investigated potential environmental factors (e.g., landscape, soil, and groundwater), as well as conditions that could have driven sake brewers away from the coastal area. Many of the sake breweries that no longer exist were located on coastal dunes (i.e., sand, sandbanks, and natural levees) and obtained their water from a freshwater layer located 3-10 m below the surface. We speculate that these sake breweries benefited from using natural ingredients found in the coastal zone. We also investigated the following factors that may have negatively impacted the breweries, driving them out of business: (1) bankruptcies and reconstruction difficulties that followed the destructive 1923 Great Kanto earthquake, (2) industrial wartime adjustments during World War II (1939-1945), (3) development of coastal industries during the period from 1960 to 1975, and (4) increasing choices for other alcoholic drinks (e.g., beer, wine, and whiskey) from the 1960s to the present.[Figure not available: see fulltext.
Li, Huafang; Li, Yan; Feng, Yu; Zhuo, Jianmin; Turkoz, Ibrahim; Mathews, Maju; Tan, Wilson
To evaluate the differences in efficacy and safety outcomes in acute exacerbating schizophrenia patients between 2 subgroups (≤1 week and >1 week), differing in time interval from hospitalization to time of initiation of once-monthly paliperidone palmitate. PREVAIL was a multicenter, single-arm, open-label, prospective Phase IV study in hospitalized Asian patients (either sex, aged 18-65 years) diagnosed with schizophrenia ( Diagnostic and Statistical Manual of Mental Disorders , Fourth Edition). Change from baseline to week 13 in primary (Positive and Negative Syndrome Scale [PANSS] total score), secondary endpoints (PANSS responder rate, PANSS subscale, PANSS Marder factor, Clinical Global Impression-Severity, and Personal and Social Performance scale scores, readiness for hospital discharge questionnaire) and safety were assessed in this post hoc analysis. Significant mean reduction from baseline to week 13 in the PANSS total score, 30% PANSS responder rates ( P ≤0.01), PANSS subscales (positive and general psychopathology; all P ≤0.01), PANSS Marder factor (positive symptoms, uncontrolled hostility, and excitement and anxiety/depression; all P ≤0.01), Personal and Social Performance scale scores ( P ≤0.05) and Clinical Global Impression-Severity categorical summary ( P ≤0.05) were significantly greater in the ≤1 week subgroup versus >1 week subgroup ( P ≤0.05). The readiness for hospital discharge questionnaire improved over time for the overall study population, but remained similar between subgroups at all-time points. Treatment-emergent adverse events were similar between the subgroups. Early initiation of once-monthly paliperidone palmitate in hospitalized patients with acute exacerbation of schizophrenia led to greater improvements in psychotic symptoms with comparable safety than treatment initiation following 1 week of hospitalization.
Meddings, Jennifer; Reichert, Heidi; Smith, Shawna N; Iwashyna, Theodore J; Langa, Kenneth M; Hofer, Timothy P; McMahon, Laurence F
Readmission rates after pneumonia, heart failure, and acute myocardial infarction hospitalizations are risk-adjusted for age, gender, and medical comorbidities and used to penalize hospitals. To assess the impact of disability and social determinants of health on condition-specific readmissions beyond current risk adjustment. Retrospective cohort study of Medicare patients using 1) linked Health and Retirement Study-Medicare claims data (HRS-CMS) and 2) Healthcare Cost and Utilization Project State Inpatient Databases (Florida, Washington) linked with ZIP Code-level measures from the Census American Community Survey (ACS-HCUP). Multilevel logistic regression models assessed the impact of disability and selected social determinants of health on readmission beyond current risk adjustment. Outcomes measured were readmissions ≤30 days after hospitalizations for pneumonia, heart failure, or acute myocardial infarction. HRS-CMS models included disability measures (activities of daily living [ADL] limitations, cognitive impairment, nursing home residence, home healthcare use) and social determinants of health (spouse, children, wealth, Medicaid, race). ACS-HCUP model measures were ZIP Code-percentage of residents ≥65 years of age with ADL difficulty, spouse, income, Medicaid, and patient-level and hospital-level race. For pneumonia, ≥3 ADL difficulties (OR 1.61, CI 1.079-2.391) and prior home healthcare needs (OR 1.68, CI 1.204-2.355) increased readmission in HRS-CMS models (N = 1631); ADL difficulties (OR 1.20, CI 1.063-1.352) and 'other' race (OR 1.14, CI 1.001-1.301) increased readmission in ACS-HCUP models (N = 27,297). For heart failure, children (OR 0.66, CI 0.437-0.984) and wealth (OR 0.53, CI 0.349-0.787) lowered readmission in HRS-CMS models (N = 2068), while black (OR 1.17, CI 1.056-1.292) and 'other' race (OR 1.14, CI 1.036-1.260) increased readmission in ACS-HCUP models (N = 37,612). For acute myocardial infarction, nursing home status
Manto, Mario; Oulad Ben Taib, Nordeyn
Although considerable progress has been made in developing models of cerebellar function in sensorimotor control, the exact nature of the basic operations performed by the cerebellum remain elusive. Several major theories have emerged these last decades. According to the hypothesis of Marr and Albus, the climbing fiber input carries an error signal weakening the strength of a subset of parallel fibers/Purkinje neurons synapses in the cerebellar cortex. Cerebellar circuits would gain the control of movement through trial and error. The hypothesis of internal models emulating movements is currently highly cited. There is a general agreement that (1) the central nervous system has to cope with an intrinsic time delay of sensory feedback related to motor activities and (2) estimations of future motor states are essential to perform fast and accurate movements. According to this second theory, cerebellar dysmetria, one of the cardinal cerebellar deficits, would result from a distorted predictive control. A third popular theory relates to the inverse models that would be stored in the cerebellum. Acquisition of a motor act would require forward models, and the acquisition process itself would generate an inverse model to allow an unconscious coordinated movement. Recently, an international panel of experts from various disciplines discussed the prevailing opinions in a consensus statement and tried to extract their clinical relevance in terms of pathogenesis of the clinical symptoms. Although a consensus is still not reached, the prevailing opinions provide a sound framework to conduct novel studies and try to discover the secrets of cerebellar circuits.
Daud@Fhiri Nur Suriaty; Diyana Ishak Siti Intan; Abdullah Suhairimi; Azmi A. A.; Ishak Aida Shakila; Ahmad Z.
The purpose of this article is to explore the various discussion of social entrepreneurship. Social entrepreneurship provides a unique opportunity and assumptions to question, challenge and rethink from different perspective of management and business research. This article offers a comparative analysis of commercial entrepreneurship and social entrepreneurship using a prevailing analytical model from commercial entrepreneurship. The analysis highlights key differences and similarities betwee...
Versen, Christopher R.
The simplest and most widely held definition of Social Darwinism is the application of concepts of biological evolution to social and moral development. More specifically, it is social evolution through "survival of the fittest" in a "struggle for existence" in which the strong prevail and the weak are defeated and disappear.…
Lytton, Simon David; Schluter, Anke; Banga, Paul J
Autoantibodies to the thyrotropin hormone receptor (TSH-R) are directly responsible for the hyperthyroidism in Graves' disease and mediate orbital manifestations in Graves' orbitopathy (otherwise known as thyroid eye disease). These autoantibodies are heterogeneous in their function and collectively referred to as TRAbs. Measurement of TRAbs is clinically important for diagnosis of a variety of conditions and different commercial assays with high sensitivity and specificity are available for diagnostic purposes. This review provides overwhelming evidence that the TRAbs detected in binding assays by mainly the automated electrochemical luminescence immunoassays (ECLIA) do not distinguish TRAbs that stimulate the TSH-R (called TSIs or TSAbs) and TRAbs that just inhibit the binding of TSH without stimulating the TSH-R (called TBAbs). However, TSAbs and TBAbs have divergent pathogenic roles, and depending which fraction predominates cause different clinical symptoms and engender different therapeutic regimen. Therefore, diagnostic distinction of TSAbs and TBAbs is of paramount clinical importance. To date, only bioassays such as the Mc4 TSH-R bioassay (Thyretain TM , Quidel) and the Bridge assay (Immulite 2000, Siemens) can measure TSAbs, with only the former being able to distinguish between TSAbs and TBAbs. On this note, it is strongly recommended to only use the term TSI or TSAb when reporting the results of bioassays, whereas the results of automated TRAb binding assays should be reported as TRAbs (of undetermined functional significance). This review aims to present a technical and analytical account of leading commercial diagnostic methods of anti-TSH-R antibodies, a metaanalysis of their clinical performance and a perspective for the use of cell based TSH-R bioassays in the clinical diagnostics of Graves' disease.
Kraft, Beate; Engelen, Bert; Goldhammer, Tobias; Lin, Yu-Shih; Cypionka, Heribert; Könneke, Martin
Sediments of coastal upwelling areas are generally characterized by a high content of organic carbon that is mainly degraded via anaerobic microbial processes including sulfate reduction as a major terminal oxidation step. Despite the high importance of sulfate reduction in these sediments, the identity of sulfate-reducing bacteria (SRB) has remained almost unknown. Here, we applied a cultivation-based approach using selective enrichment conditions to study the diversity and distribution of active SRB in sediments along a transect perpendicular to the continental slope off the coast of Namibia (Meteor-cruise M76/1). To promote growth of the most abundant SRB, dilution series were prepared and amended with hydrogen, acetate, or a mixture of monomers representing typical substrates for SRB. Growth of SRB could be detected in the presence of all electron donors and from sediment down to 4 m depth. 16S rRNA gene-based DGGE analysis and sequencing revealed the predominance of SRB related to psychrophiles in particular to the genus Desulfofrigus, which made up 1 % of the total microbial community, accounting for an absolute abundance of up to 4.8 × 10(7) cells mL(-1) . In general, the abundance of cultured SRB changed with depth and between the different sampling sites and correlated with the content of organic carbon as previously reported. Growth of chemolithotrophic SRB in relatively high dilution steps and the enrichment of methanogens as well as acetogens from deeper sediment point to a competition between hydrogen-utilizing microbial processes and their biogeochemical significance in deep sediment layers of the Benguela upwelling area. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Prast, Janine M; Schardl, Aurelia; Schwarzer, Christoph; Dechant, Georg; Saria, Alois; Zernig, Gerald
We investigated if counterconditioning with dyadic (i.e., one-to-one) social interaction, a strong inhibitor of the subsequent reacquisition of cocaine conditioned place preference (CPP), differentially modulates the activity of the diverse brain regions oriented along a mediolateral corridor reaching from the interhemispheric sulcus to the anterior commissure, i.e., the nucleus of the vertical limb of the diagonal band, the medial septal nucleus, the major island of Calleja, the intermediate part of the lateral septal nucleus, and the medial accumbens shell and core. We also investigated the involvement of the lateral accumbens core and the dorsal caudate putamen. The anterior cingulate 1 (Cg1) region served as a negative control. Contrary to our expectations, we found that all regions of the accumbens corridor showed increased expression of the early growth response protein 1 (EGR1, Zif268) in rats 2 h after reacquisition of CPP for cocaine after a history of cocaine CPP acquisition and extinction. Previous counterconditioning with dyadic social interaction inhibited both the reacquisition of cocaine CPP and the activation of the whole accumbens corridor. EGR1 activation was predominantly found in dynorphin-labeled cells, i.e., presumably D1 receptor-expressing medium spiny neurons (D1-MSNs), with D2-MSNs (immunolabeled with an anti-DRD2 antibody) being less affected. Cholinergic interneurons or GABAergic interneurons positive for parvalbumin, neuropeptide Y or calretinin were not involved in these CPP-related EGR1 changes. Glial cells did not show any EGR1 expression either. The present findings could be of relevance for the therapy of impaired social interaction in substance use disorders, depression, psychosis, and autism spectrum disorders.
Williams, Allison; Sethi, Bharati; Duggleby, Wendy; Ploeg, Jenny; Markle-Reid, Maureen; Peacock, Shelley; Ghosh, Sunita
A little-studied issue in the provision of care at home by informal caregivers is the increase in older adult patients with chronic illness, and more specifically, multiple chronic conditions (MCC). We know little about the caregiving experience for this population, particularly as it is affected by social location, which refers to either a group's or individual's place/location in society at a given time, based on their intersecting demographics (age, gender, education, race, immigration status, geography, etc.). We have yet to fully comprehend the combined influence of these intersecting axes on caregivers' health and wellbeing, and attempt to do this by using an intersectionality approach in answering the following research question: How does social location influence the experience of family caregivers of older adults with MCC? The data presented herein is a thematic analysis of a qualitative sub-set of a large two-province study conducted using a repeated-measures embedded mixed method design. A survey sub-set of 20 survey participants per province (n = 40 total) were invited to participate in a semi-structured interview. In the first stage of data analysis, Charmaz's (2006) Constructivist Grounded Theory Method (CGTM) was used to develop initial codes, focused codes, categories and descriptive themes. In the second and the third stages of analysis, intersectionality was used to develop final analytical themes. The following four themes describe the overall study findings: (1) Caregiving Trajectory, where three caregiving phases were identified; (2) Work, Family, and Caregiving, where the impact of caregiving was discussed on other areas of caregivers' lives; (3) Personal and Structural Determinants of Caregiving, where caregiving sustainability and coping were deliberated, and; (4) Finding Meaning/Self in Caregiving, where meaning-making was highlighted. The intersectionality approach presented a number of axes of diversity as comparatively more important
Pinheiro, Barbara S; Seidl, Simon S; Habazettl, Eva; Gruber, Bernadette E; Bregolin, Tanja; Zernig, Gerald
Impaired social interaction is a hallmark symptom of many psychiatric diseases, including dependence syndromes (substance use disorders). Helping the addict reorient her/his behavior away from the drug of abuse toward social interaction would be of considerable therapeutic benefit. To study the neural basis of such a reorientation, we have developed several animal models in which the attractiveness of a dyadic (i.e. one-to-one) social interaction (DSI) can be compared directly with that of cocaine as a prototypical drug of abuse. Our models are based on the conditioned place preference (CPP) paradigm. In an ongoing effort to validate our experimental paradigms in C57BL/6 mice to make use of the plethora of transgenic models available in this genus, we found the following: (a) DSI with a live mouse produced CPP, whereas an interaction with an inanimate mouse-like object (i.e. a 'toy mouse'; toy mouse interaction) led to conditioned place aversion - but only in the Jackson substrain (C57BL/6J). (b) In the NIH substrain (C57BL/6N), both DSI and toy mouse interaction produced individual aversion in more than 50% of the tested mice. (c) Four 15 min DSI episodes did not result in the development of an observable hierarchy, that is, dominance/subordination behavior in the overwhelming majority (i.e. 30 of 32) of the tested Jackson mouse pairs. Therefore, dominance/subordination does not seem to be a confounding variable in our paradigm, at least not in C57BL/6J mice. Respective data for NIH mice were too limited to allow any conclusion. The present findings indicate that (a) DSI with a live mouse produces CPP to a greater degree than an interaction with an inanimate object resembling a mouse and that (b) certain substrain differences with respect to CPP/aversion to DSI do exist between the Jax and NIH substrain of C57BL/6 mice. These differences have to be considered when choosing a proper mouse substrain model for investigating the neural basis of DSI reward versus
Pinheiro, Barbara S.; Seidl, Simon S.; Habazettl, Eva; Gruber, Bernadette E.; Bregolin, Tanja
Impaired social interaction is a hallmark symptom of many psychiatric diseases, including dependence syndromes (substance use disorders). Helping the addict reorient her/his behavior away from the drug of abuse toward social interaction would be of considerable therapeutic benefit. To study the neural basis of such a reorientation, we have developed several animal models in which the attractiveness of a dyadic (i.e. one-to-one) social interaction (DSI) can be compared directly with that of cocaine as a prototypical drug of abuse. Our models are based on the conditioned place preference (CPP) paradigm. In an ongoing effort to validate our experimental paradigms in C57BL/6 mice to make use of the plethora of transgenic models available in this genus, we found the following: (a) DSI with a live mouse produced CPP, whereas an interaction with an inanimate mouse-like object (i.e. a ‘toy mouse’; toy mouse interaction) led to conditioned place aversion – but only in the Jackson substrain (C57BL/6J). (b) In the NIH substrain (C57BL/6N), both DSI and toy mouse interaction produced individual aversion in more than 50% of the tested mice. (c) Four 15 min DSI episodes did not result in the development of an observable hierarchy, that is, dominance/subordination behavior in the overwhelming majority (i.e. 30 of 32) of the tested Jackson mouse pairs. Therefore, dominance/subordination does not seem to be a confounding variable in our paradigm, at least not in C57BL/6J mice. Respective data for NIH mice were too limited to allow any conclusion. The present findings indicate that (a) DSI with a live mouse produces CPP to a greater degree than an interaction with an inanimate object resembling a mouse and that (b) certain substrain differences with respect to CPP/aversion to DSI do exist between the Jax and NIH substrain of C57BL/6 mice. These differences have to be considered when choosing a proper mouse substrain model for investigating the neural basis of DSI reward
Bryce, A H; Alumkal, J J; Armstrong, A; Higano, C S; Iversen, P; Sternberg, C N; Rathkopf, D; Loriot, Y; de Bono, J; Tombal, B; Abhyankar, S; Lin, P; Krivoshik, A; Phung, D; Beer, T M
Advanced prostate cancer is a phenotypically diverse disease that evolves through multiple clinical courses. PSA level is the most widely used parameter for disease monitoring, but it has well-recognized limitations. Unlike in clinical trials, in practice, clinicians may rely on PSA monitoring alone to determine disease status on therapy. This approach has not been adequately tested. Chemotherapy-naive asymptomatic or mildly symptomatic men (n=872) with metastatic castration-resistant prostate cancer (mCRPC) who were treated with the androgen receptor inhibitor enzalutamide in the PREVAIL study were analyzed post hoc for rising versus nonrising PSA (empirically defined as >1.05 vs ⩽1.05 times the PSA level from 3 months earlier) at the time of radiographic progression. Clinical characteristics and disease outcomes were compared between the rising and nonrising PSA groups. Of 265 PREVAIL patients with radiographic progression and evaluable PSA levels on the enzalutamide arm, nearly one-quarter had a nonrising PSA. Median progression-free survival in this cohort was 8.3 months versus 11.1 months in the rising PSA cohort (hazard ratio 1.68; 95% confidence interval 1.26-2.23); overall survival was similar between the two groups, although less than half of patients in either group were still at risk at 24 months. Baseline clinical characteristics of the two groups were similar. Non-rising PSA at radiographic progression is a common phenomenon in mCRPC patients treated with enzalutamide. As restaging in advanced prostate cancer patients is often guided by increases in PSA levels, our results demonstrate that disease progression on enzalutamide can occur without rising PSA levels. Therefore, a disease monitoring strategy that includes imaging not entirely reliant on serial serum PSA measurement may more accurately identify disease progression.
Ostman, Pär-Olov; Wennerberg, Ann; Albrektsson, Tomas
Recently, a new implant surface texture, featuring application of nanometer-scale calcium phosphate has been shown to enhance early bone fixation and formation in preclinical studies and in human histomorphometric studies, which may be beneficial in immediate loading situations. The purpose of the present prospective clinical study was to, during 1 year, clinically and radiographically evaluate a nanometer scale surface modified implant placed for immediate loading of fixed prostheses in both maxillary and mandibular regions. Thirty-five out of 38 patients who needed implant treatment and met inclusion criteria agreed to participate in the study and were consecutively enrolled. Surgical implant placement requirements consisted of a final torque of a least 25 Ncm prior to final seating and an implant stability quotient above 55. A total of 102 NanoTite PREVAIL (NTP) implants (BIOMET 3i, Palm Beach Gardens, FL, USA) (66 maxillary and 36 mandibular) were placed by one investigator, and the majority of these were placed in posterior regions (65%) and in soft bone (69%). A total of 44 prosthetic constructions were evaluated consisting of 14 single-tooth restorations, 26 fixed partial dentures, and four complete fixed restorations. All provisional constructions were delivered within 1 hour, and the final constructions placed after 4 months. Implants were monitored for clinical and radiographic outcomes at follow-up examinations scheduled for 3, 6, and 12 months. Of the 102 study implants, one implant failed. The simple cumulative survival rate value at 1 year was 99.2%. The average marginal bone resorption was 0.37 mm (SD 0.39) during the first year in function. According to the success criteria of Albrektsson and Zarb, success grade 1 was found with 93% of the implants. Although limited to the short follow-up, immediate loading of NanoTite Prevail implants seems to be a viable option in implant rehabilitation, at least when a good initial fixation is achieved.
Walther, Thomas; Thielmann, Matthias; Kempfert, Joerg; Schroefel, Holger; Wimmer-Greinecker, Gerhard; Treede, Hendrik; Wahlers, Thorsten; Wendler, Olaf
The study aimed to evaluate 1-year outcomes of the multicentre PREVAIL transapical (TA) study of TA-aortic valve implantation (AVI) in high-risk patients. From September 2009 to August 2010, a total of 150 patients, aged 81.6 ± 5.8 years, 40.7% female, were included at 12 European TA-AVI experienced sites. Patients received 23 (n = 36), 26 (n = 57) and 29 mm (n = 57) second-generation SAPIEN XT™ (Edwards Lifesciences, Irvine, CA, USA) valves. The mean logistic EuroSCORE was 24.3 ± 7.0, and mean Society Thoracic Surgeons score was 7.5 ± 4.4%. Survival was 91.3% at 30 days and 77.9% at 1 year. Subgroup analysis revealed survivals of 91.7/88.9, 86.0/70.2, 96.55/91.2% for patients receiving 23-, 26- and 29-mm valves at 30 days and at 1 year, respectively. Transthoracic echocardiography revealed preserved left ventricular ejection fraction and low gradients. Aortic incompetence was none in 41/48, trace 30/36, mild 22/12 and moderate in 7/4% at discharge and 1 year. Walking distance increased from 221 (postimplant) to 284 m (at 1 year, P = 0.0004). Three patients required reoperation due to increasing aortic incompetence during follow-up. Causes of mortality at 1 year were cardiac (n = 7), stroke (n = 1) and others (n = 5). The European PREVAIL multicentre trial demonstrates good functionality and good outcomes for TA-AVI using the second-generation SAPIEN XT prosthesis and the ASCENDRA-II delivery system. The 29-mm SAPIEN XT valve was successfully introduced and showed excellent results.
Blanca Estela Pelcastre-Villafuerte
Full Text Available El objetivo del artículo fue analizar el apoyo social y las condiciones de vida de adultos mayores en zonas urbanas empobrecidas. Estudio cualitativo con 8 grupos focales, realizado en Guerrero, Jalisco, Morelos y Sinaloa, México, durante 2005-2006. Participaron 40 varones y 63 mujeres. El principal apoyo para la vida cotidiana y la condición de salud de los adultos mayores proviene de los familiares cercanos, en algunos casos de vecinos. Los apoyos de los adultos mayores son básicamente materiales y económicos, así como cierto tipo de acompañamiento y traslado a consultas médicas. El apoyo emocional es mínimo o inexistente, igual la compañía cotidiana y la integración en la vida familiar. Se identificó una ausencia significativa de apoyo por parte del gobierno o de organizaciones religiosas o civiles. La familia continúa siendo la fuente fundamental de apoyo. Es necesario incrementar las acciones gubernamentales para la población adulta mayor y transformar la idea de que las necesidades de esta población es una responsabilidad individual más que colectiva.The aim of this paper was to analyze social support and living conditions among poor elderly people in Mexican cities. A qualitative study with eight focus groups was carried out in Guadalajara, Cuernavaca, Chilpancingo, and Culiacan, Mexico, in 2005. Forty men and 63 women participated in the study. The main support for the elderly in daily living came from their immediate family and in some cases from neighbors. Social support was basically material and economic, in addition to providing company and transportation for medical appointments. Daily emotional support, companionship, and social inclusion were minimal or absent. The study identified a significant lack of support from government and religious or civil society organizations. The family is still the main source of support for the elderly. Increased government collaboration is dramatically needed to combat the
Cook, Penny A; Morleo, Michela; Billington, David; Sanderson-Shortt, Kevin; Jones, Colin; Gabbay, Mark; Sheron, Nick; Bellis, Mark A; Phillips-Howard, Penelope A; Gilmore, Ian T
The direct cost of excessive alcohol consumption to health services is substantial but dwarfed by the cost borne by the workplace as a result of lost productivity. The workplace is also a promising setting for health interventions. The Preventing Alcohol Harm in Liverpool and Knowsley (PrevAIL) project aimed to evaluate a mechanism for detecting the prevalence of alcohol related liver disease using fibrosis biomarkers. Secondary aims were to identify the additive effect of obesity as a risk factor for early liver disease; to assess other impacts of alcohol on work, using a cross-sectional survey. Participants (aged 36-55 y) from 13 workplaces participated (March 2011-April 2012). BMI, waist circumference, blood pressure and self-reported alcohol consumption in the previous week was recorded. Those consuming more than the accepted UK threshold (men: >21 units; female: >14 units alcohol) provided a 20 ml venous blood sample for a biomarker test (Southampton Traffic Light Test) and completed an alcohol questionnaire (incorporating the Severity of Alcohol Dependence Questionnaire). The screening mechanism enrolled 363 individuals (52 % women), 39 % of whom drank above the threshold and participated in the liver screen (n = 141, complete data = 124 persons). Workplaces with successful participation were those where employers actively promoted, encouraged and facilitated attendance. Biomarkers detected that 30 % had liver disease (25 %, intermediate; 5 % probable). Liver disease was associated with the frequency of visits to the family physician (P = 0.036) and obesity (P = 0.052). The workplace is an important setting for addressing alcohol harm, but there are barriers to voluntary screening that need to be addressed. Early detection and support of cases in the community could avert deaths and save health and social costs. Alcohol and obesity should be addressed simultaneously, because of their known multiplicative effect on liver disease risk, and because employers
Full Text Available The article analyses the development of the relationship between social work and social pedagogy at the end of the 20th century in the Czech Republic and compares this relationship to the one in neighbouring countries (Germany, England, France, Switzerland, Denmark, Sweden, Finland, Poland, Slovakia, Russia, Lithuania. The article further deals with various concepts of this relationship (including identification, differentiation, and convergent principle. It also compares the paradigms of social pedagogy and social work (autonomy, similarities and differences mainly in epistemological terms. Series of paradigms appear in both social work and social pedagogy during their development. A prevailing tendency towards the multi-paradigmatism can be seen. Furthermore, the article discusses the differences in professional aspirations within both fields and the number of job opportunities for the fields graduates. A conclusion of the article is dedicated to the professional career within social pedagogy and social work regarding the real life situation in both fields.
Aleksandra Anatol’evna Shabunova
Full Text Available The article considers theoretical aspects of a scientific research “The Mechanisms for Overcoming Mental Barriers of Inclusion of Socially Vulnerable Categories of the Population for the Purpose of Intensifying Modernization in the Regional Community” (RSF grant No. 16-18-00078. The authors analyze the essence of the category of “socially vulnerable groups” from the legal, economic and sociological perspectives. The paper shows that the economic approach that uses the criterion “the level of income and accumulated assets” when defining vulnerable population groups prevails in public administration practice. The legal field of the category based on the economic approach is defined by the concept of “the poor and socially unprotected categories of citizens”. With the help of the analysis of theoretical and methodological aspects of this issue, the authors show that these criteria are a necessary but not sufficient condition for classifying the population as being socially vulnerable. Foreign literature associates the phenomenon of vulnerability with the concept of risks, with the possibility of households responding to them and with the likelihood of losing the well-being (poverty theory; research areas related to the means of subsistence, etc.. The asset-based approaches relate vulnerability to the poverty that arises due to lack of access to tangible and intangible assets. Sociological theories presented by the concept of social exclusion pay much attention to the breakdown of social ties as a source of vulnerability. The essence of social exclusion consists in the inability of people to participate in important aspects of social life (in politics, labor markets, education and healthcare, cultural life, etc. though they have all the rights to do so. The difference between the concepts of exclusion and poverty is manifested in the displacement of emphasis from income inequality to limited access to rights. Social exclusion is
Azzinnari, Damiano; Sigrist, Hannes; Staehli, Simon; Palme, Rupert; Hildebrandt, Tobias; Leparc, German; Hengerer, Bastian; Seifritz, Erich; Pryce, Christopher R
In neuropsychiatry, animal studies demonstrating causal effects of environmental manipulations relevant to human aetiology on behaviours relevant to human psychopathologies are valuable. Such valid models can improve understanding of aetio-pathophysiology and preclinical discovery and development of new treatments. In depression, specific uncontrollable stressful life events are major aetiological factors, and subsequent generalized increases in fearfulness, helplessness and fatigue are core symptoms or features. Here we exposed adult male C57BL/6 mice to 15-day psychosocial stress with loss of social control but minimal physical wounding. One cohort was assessed in a 3-day test paradigm of motor activity, fear conditioning and 2-way avoid-escape behaviour on days 16-18, and a second cohort was assessed in a treadmill fatigue paradigm on days 19 and 29, followed by the 3-day paradigm on days 30-32. All tests used a physical aversive stimulus, namely mild, brief electroshocks. Socially stressed mice displayed decreased motor activity, increased fear acquisition, decreased 2-way avoid-escape responding (increased helplessness) and increased fatigue. They also displayed increased plasma TNF and spleen hypertrophy, and adrenal hypertrophy without hyper-corticoidism. In a third cohort, psychosocial stress effects on brain gene expression were assessed using next generation sequencing. Gene expression was altered in pathways of inflammation and G-protein coupled receptors in prefrontal cortex and amygdala; in the latter, expression of genes important in dopamine function were de-regulated including down-regulated Drd2, Adora2a and Darpp-32. This model can be applied to identify targets for treating psychopathologies such as helplessness or fatigue, and to screen compounds/biologics developed to act at these targets. Copyright © 2014 Elsevier Ltd. All rights reserved.
Jensen, Mads Dagnis; Snaith, Holly
This article analyses Britain’s quest to negotiate its future membership of the European Union (EU) through the lens of Liberal intergovernmentalism. The article demonstrates that despite the significant economic consequences of a potential Brexit, party political factors have hitherto proven more...
Mueck, K.; Suda, M.
In the Research Center Seibersdorf the computer simulation code OECOSYS was installed in 1989 which represents a version of the model ECOSYS-87 developed by GSF in Neuherberg, and adapted to the Austrian situation. The model available since then simulates from input parameters such as the integral of the activity concentration in air and the ground deposition of each radionuclide as well as the precipitation values via the interception on plants and deposition on soil and the transfer of radionuclides into the various ecosystems and fodder-food chains into the various foodstuffs and calculates in this way the course of the activity concentration in these foodstuffs. Via the consumption rates of each foodstuff the contribution of the ingestion of each foodstuff and by that the total ingestion dose may be evaluated. Further, the simulation model permits the calculation of the various exposure pathways as inhalation and external irradiation from the plume and ground and enable the user to obtain a fast comparison of the various exposure pathways. In order to ensure the availability of the code and the accompanying infrastructure, by order of the federal chancellery sect. VI the computer code is run in certain intervals and test calculations are performed with it. Each exercise run was based on scenarios which could result in case of severe accidents in neighboring nuclear power plants. Generally, extremely unrealistic scenarios were assumed which do not correspond to the safety standard of the respective nuclear power plant in order to obtain calculation examples which may serve the emergency units in their planning for emergency situations. Furthermore, by these exercise runs a demonstration of the contribution of the various exposure pathways for the persons responsible for emergency management in case of a crisis shall be given to enable them to appropriately design the respective planning features. In the present report the calculations performed up to now are compiled and comparatively displayed. (author)
Rice, A. R.
The significant correlation between dropping temperatures throughout the Pliocene and the concomitant explosive expansion of the Hominid brain has led a number of workers to postulate climate change drove human evolution. Our brain (that of Homo sapiens), comprises 1-2 percent of our body weight but consumes 20 -25 percent of the body's caloric intake. We are "hotheads". Brains are extremely sensitive to overheating but we are endowed with unparalleled thermal regulation, much of it given over to protecting the Central Nervous System (CNS). Will there be reversed trends with global warming? The human brain has been shrinking since the end of the Ice Ages, losing about 150cc over the past 10,000 years. Polar bear skulls have been downsizing as well. Almost all mass extinctions or evolutionary upheavals are attributed to global warming: e.g. the Permian/Triassic (P/T) event, i.e., "The Great Dying", 250 million years ago (~90% of all life forms wiped out); the Paleocene/ Eocene Thermal Maximum (PETM) 55 million years ago. They may be analogs for what might await us. Large creatures, whose body size inhibits cooling, melted away during the PETM. Horses, initially the size of dogs then, reduced to the size of cats. An unanticipated hazard for humans that may attend extreme global warming is dumbing down or needing to retreat to the Poles as did those creatures that survived the P/T event (some references: http://johnhawks.net/research/hawks-2011-brain-size-selection-holocene; Kandel, E. et al Principles of Neural Science 4th ed. New York (US): McGraw-Hill, 2000; Selective Brain Cooling in Early Hominids:phylogenetic and evolutionary implications, Reeser, H., firstname.lastname@example.org; How the body controls brain temperature; the temperature shielding effect of cerebral blood flow, Mingming Z. et al. J Appl Physiol. 2006 November; 101(5): 1481-1488; news.nationalgeographic.com/ news/2014/03/140327-climate-change-shrinks-salamanders-global-warming-science/; Heat illness and heat stroke, www.ozemedicine.com/wiki/doku.php?id=heat illness 7/3/2010)
Full Text Available We propose to show in our paper that through his semiotic theory, Barthes developed a theory of subjectivity and society continued with the anti-utilitarian tradition of the Collège de Sociologie where George Bataille, Carl Einstein or Michel Leiris had favored the mythical and ritual dimension of collective life.
Full Text Available Potential of root system of plants from wide range of families to effectively reduce membrane impermeable ferricyanide to ferrocyanide and blue coloured 2,6-dichlorophenol indophenol (DCPIP to colourless DCPIPH2 both under non-sterile and sterile conditions, revealed prevalence of immense reducing strength at root surface. As generation of silver nanoparticles (NPs from Ag+ involves reduction, present investigations were carried to evaluate if reducing strength prevailing at surface of root system can be exploited for reduction of Ag+ and exogenous generation of silver-NPs. Root system of intact plants of 16 species from 11 diverse families of angiosperms turned clear colorless AgNO3 solutions, turbid brown. Absorption spectra of these turbid brown solutions showed silver-NPs specific surface plasmon resonance peak. Transmission electron microscope coupled with energy dispersive X-ray confirmed the presence of distinct NPs in the range of 5-50 nm containing Ag. Selected area electron diffraction and powder X-ray diffraction patterns of the silver NPs showed Bragg reflections, characteristic of crystalline face-centered cubic structure of Ag(0 and cubic structure of Ag2O. Root system of intact plants raised under sterile conditions also generated Ag(0/Ag2O-NPs under strict sterile conditions in a manner similar to that recorded under non-sterile conditions. This revealed the inbuilt potential of root system to generate Ag(0/Ag2O-NPs independent of any microorganism. Roots of intact plants reduced triphenyltetrazolium to triphenylformazon and impermeable ferricyanide to ferrocyanide, suggesting involvement of plasma membrane bound dehydrogenases in reduction of Ag+ and formation of Ag(0/Ag2O-NPs. Root enzyme extract reduced triphenyltetrazolium to triphenylformazon and Ag+ to Ag(0 in presence of NADH, clearly establishing potential of dehydrogenases to reduce Ag+ to Ag(0, which generate Ag(0/Ag2O-NPs. Findings presented in this manuscript put
Full Text Available Huafang Li,1,2 Yan Li,1,2 Yu Feng,3 Jianmin Zhuo,4 Ibrahim Turkoz,5 Maju Mathews,5 Wilson Tan3 1Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China; 3Janssen Pharmaceutical Companies of Johnson and Johnson, Singapore; 4Janssen China Research and Development, Shanghai, China; 5Janssen Research & Development LLC, Titusville, NJ, USA Purpose: To evaluate the differences in efficacy and safety outcomes in acute exacerbating schizophrenia patients between 2 subgroups (≤1 week and >1 week, differing in time interval from hospitalization to time of initiation of once-monthly paliperidone palmitate. Patients and methods: PREVAIL was a multicenter, single-arm, open-label, prospective Phase IV study in hospitalized Asian patients (either sex, aged 18–65 years diagnosed with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Change from baseline to week 13 in primary (Positive and Negative Syndrome Scale [PANSS] total score, secondary endpoints (PANSS responder rate, PANSS subscale, PANSS Marder factor, Clinical Global Impression-Severity, and Personal and Social Performance scale scores, readiness for hospital discharge questionnaire and safety were assessed in this post hoc analysis. Results: Significant mean reduction from baseline to week 13 in the PANSS total score, 30% PANSS responder rates (P≤0.01, PANSS subscales (positive and general psychopathology; all P≤0.01, PANSS Marder factor (positive symptoms, uncontrolled hostility, and excitement and anxiety/depression; all P≤0.01, Personal and Social Performance scale scores (P≤0.05 and Clinical Global Impression-Severity categorical summary (P≤0.05 were significantly greater in the ≤1 week subgroup versus >1 week subgroup (P≤0.05. The readiness for hospital discharge questionnaire improved over time for the overall study population, but
Saad, F; Ivanescu, C; Phung, D; Loriot, Y; Abhyankar, S; Beer, T M; Tombal, B; Holmstrom, S
We investigated the impact of skeletal-related events (SREs) on health-related quality of life (HRQoL) in patients with metastatic castration-resistant prostate cancer (mCRPC) in phase III trials of enzalutamide versus placebo. Patients with mCRPC experiencing at least one SRE during AFFIRM and PREVAIL were assessed for trajectory-adjusted mean change in HRQoL by first SRE using Functional Assessment of Cancer Therapy-Prostate (FACT-P; AFFIRM, three domains, and PREVAIL, nine domains) and EQ-5D (PREVAIL) instruments. First SREs caused HRQoL deterioration in both trials. Spinal cord compression had the largest impact, with clinically meaningful reductions in seven of nine FACT-P domains in PREVAIL and all three in AFFIRM (mean (95% confidence interval (CI)) change in FACT-P total score -16.95 (-26.47, -7.44) and -9.69 (-16.10, -3.27), respectively). In PREVAIL, first SREs caused clinically meaningful declines in EQ-5D utility index, irrespective of category; spinal cord compression had the largest impact (mean (95% CI) change -0.24 (-0.39, -0.08)). In AFFIRM, FACT-P and FACT-General total scores showed clinically meaningful declines after radiation/surgery to bone. SREs were associated with clinically meaningful functional declines in the daily lives of patients with mCRPC. Spinal cord compression had the largest impact on HRQoL.
Violência e desigualdade social: mortalidade por homicídios e condições de vida em Salvador, Brasil Violence and social inequalities: mortality rates due to homicides and life conditions in Salvador, Brazil
Adriana C Macedo
used to define a four-category variable related to living conditions. Mortality rates due to homicide and the relative risk regarding the lowest living condition area were calculated for each social stratum. The 95% confidence intervals were calculated using the Confidence Interval Analysis software. RESULTS: The highest mortality rates due to homicide were seen in the poorest areas. The relative risk due to homicide for the lowest and the highest living condition areas was statistically significant at 5% level and ranged from 2.9 to 5.1. CONCLUSIONS: The data show a strong association between social inequalities and homicide in this urban area, emphasizing the importance of crime reduction programs.
Sawa, Yoshiki; Takayama, Morimasa; Mitsudo, Kazuaki; Nanto, Shinsuke; Takanashi, Shuichiro; Komiya, Tatsuhiko; Kuratani, Toru; Tobaru, Tetsuya; Goto, Tsuyoshi
Transcatheter aortic valve replacement (TAVR) is suggested to be less invasive and/or equally effective in comparison to conventional aortic valve replacement for high-risk symptomatic aortic stenosis patients. We herein report the initial results of a pivotal clinical trial of TAVR in Japan (the PREVAIL JAPAN). Sixty-four aortic stenosis patients (mean age 84.3 ± 6.1 years) not suitable for surgery were enrolled at three centers in Japan, with a primary composite endpoint of the 6-month post-procedure improvements in the aortic valve area and New York Heart Association (NYHA) functional classification. A transfemoral approach was used in 37 patients and a transapical approach was used in 27. The device success rate was 91.9 %. After 30 days and 6 months, the rates of mortality from any cause were 8.1 and 11.3 %, respectively. At 6 months, symptomatic stroke was found in 3.1 % of the patients, and silent infarction in 7.8 %. The aortic valve area and mean pressure gradient were significantly improved over time with both approaches (p < 0.001). At 6 months, the NYHA functional classification based on a conventional physician's assessment was improved in 87.9 % of the patients. We found results that were equivalent to those in other major TAVR trials, such as an acceptable 30-day survival (91.9 %), suggesting that balloon-expandable TAVR is effective for small Japanese AS patients classified as high-risk or inoperable.
Guerini, Franca R; Bolognesi, Elisabetta; Chiappedi, Matteo; Manca, Salvatorica; Ghezzo, Alessandro; Agliardi, Cristina; Zanette, Michela; Littera, Roberto; Carcassi, Carlo; Sotgiu, Stefano; Clerici, Mario
The activity of natural killer (NK) cells is modulated by the interaction between killer-cell immune globulin-like receptor (KIR) proteins and their cognate HLA ligands; activated NK cells produce inflammatory cytokines and mediate innate immune responses. Activating KIR/HLA complexes (aKIR/HLA) were recently suggested to prevail in children with autism spectrum disorders (ASD), a neurodevelopmental syndrome characterized by brain and behavioral abnormalities and associated with a degree of inflammation. We verified whether such findings could be confirmed by analyzing two sample cohorts of Sardinian and continental Italian ASD children and their mothers. Results showed that aKIR/HLA are increased whereas inhibitory KIR/HLA complexes are reduced in ASD children; notably this skewing was even more significant in their mothers. KIR and HLA molecules are expressed by placental cells and by the trophoblast and their interactions result in immune activation and influence fetal, as well as central nervous system development and plasticity. Data herein suggest that in utero KIR/HLA immune interactions favor immune activation in ASD; this may play a role in the pathogenesis of the disease. Copyright © 2013 Elsevier Inc. All rights reserved.
Sasaki, Tatsuya; Okada, Isamu; Nakai, Yutaka
Indirect reciprocity is a major mechanism in the maintenance of cooperation among unrelated individuals. Indirect reciprocity leads to conditional cooperation according to social norms that discriminate the good (those who deserve to be rewarded with help) and the bad (those who should be punished by refusal of help). Despite intensive research, however, there is no definitive consensus on what social norms best promote cooperation through indirect reciprocity, and it remains unclear even how those who refuse to help the bad should be assessed. Here, we propose a new simple norm called “Staying” that prescribes abstaining from assessment. Under the Staying norm, the image of the person who makes the decision to give help stays the same as in the last assessment if the person on the receiving end has a bad image. In this case, the choice about whether or not to give help to the potential receiver does not affect the image of the potential giver. We analyze the Staying norm in terms of evolutionary game theory and demonstrate that Staying is most effective in establishing cooperation compared to the prevailing social norms, which rely on constant monitoring and unconditional assessment. The application of Staying suggests that the strict application of moral judgment is limited. PMID:28150808
Sasaki, Tatsuya; Okada, Isamu; Nakai, Yutaka
Indirect reciprocity is a major mechanism in the maintenance of cooperation among unrelated individuals. Indirect reciprocity leads to conditional cooperation according to social norms that discriminate the good (those who deserve to be rewarded with help) and the bad (those who should be punished by refusal of help). Despite intensive research, however, there is no definitive consensus on what social norms best promote cooperation through indirect reciprocity, and it remains unclear even how those who refuse to help the bad should be assessed. Here, we propose a new simple norm called "Staying" that prescribes abstaining from assessment. Under the Staying norm, the image of the person who makes the decision to give help stays the same as in the last assessment if the person on the receiving end has a bad image. In this case, the choice about whether or not to give help to the potential receiver does not affect the image of the potential giver. We analyze the Staying norm in terms of evolutionary game theory and demonstrate that Staying is most effective in establishing cooperation compared to the prevailing social norms, which rely on constant monitoring and unconditional assessment. The application of Staying suggests that the strict application of moral judgment is limited.
Sasaki, Tatsuya; Okada, Isamu; Nakai, Yutaka
Indirect reciprocity is a major mechanism in the maintenance of cooperation among unrelated individuals. Indirect reciprocity leads to conditional cooperation according to social norms that discriminate the good (those who deserve to be rewarded with help) and the bad (those who should be punished by refusal of help). Despite intensive research, however, there is no definitive consensus on what social norms best promote cooperation through indirect reciprocity, and it remains unclear even how those who refuse to help the bad should be assessed. Here, we propose a new simple norm called “Staying” that prescribes abstaining from assessment. Under the Staying norm, the image of the person who makes the decision to give help stays the same as in the last assessment if the person on the receiving end has a bad image. In this case, the choice about whether or not to give help to the potential receiver does not affect the image of the potential giver. We analyze the Staying norm in terms of evolutionary game theory and demonstrate that Staying is most effective in establishing cooperation compared to the prevailing social norms, which rely on constant monitoring and unconditional assessment. The application of Staying suggests that the strict application of moral judgment is limited.
Summarizing a congressional report on civil and military treatment of American Indians, this article asserts that the social Darwinism of the day prevailed among all congressional committee members ("Even friends of the Indian... knew American expansionism, technology, and racial ideology would reduce the Indian to a pitiful remnant...) (JC)
Social and Labour Bulletin, 1983
This group of articles discusses a variety of studies related to social security and retirement benefits. These studies are related to both developing and developed nations and are also concerned with studying work conditions and government role in administering a democratic social security system. (SSH)
Rose Marie Santini; Juan C. Calvi
This article analyzes the social logics underlying audiovisualconsumption on digital networks. We retrieved some data on the Internet globaltraffic of audiovisual files since 2008 to identify formats, modes of distributionand consumption of audiovisual contents that tend to prevail on the Web. Thisresearch shows the types of social practices which are dominant among usersand its relation to what we designate as “Internet culture”.
Silvia Maria Cintra da Silva
Full Text Available Este trabalho focaliza algumas das condições sociais da produção da atividade gráfica. Os dados foram coletados através de vídeo-gravações e de desenhos de crianças pré-escolares, em situações de produção gráfica, em sala de aula, durante um ano letivo. Baseada na abordagem histórico-cultural, a análise buscou verificar as relações entre a fala e o desenho, assim como as ações das crianças com e sobre as possibilidades funcionais dos materiais empregados na atividade gráfica e as mediações entre pares e professora. De acordo com os resultados, o impacto dos eventos interativos, em especial os processos de linguagem na atividade de desenho, indicam a necessidade de revisão da ênfase maturacionista nas atuais discussões teóricas sobre o tema.This essay focuses on some of the social conditions of the production of graphic activity. The data was collected through video recordings and of drawings made by pre-school children involved in classroom graphic activities during the school year. Based on a historic-cultural approach, this analysis strives to verify the relation between speech and drawing productions as well as the childrens' interaction with eachother and with the teacher. According to the results, the impact of interactive events, especially the process of language within the graphic activities, indicates a necessity of revision of the maturacionist emphasis of the theoretical discussions about the theme.
Full Text Available Background: Malocclusion is problem since antiquity. But people’s perception about the problem varies with their geographical location and cultural background. The problem seems to be more acute in developing countries like Bangladesh. Objectives: The present study was undertaken to assess the awareness about aesthetic problem of malocclusion and treatment seeking behavior among the patients attending in orthodontic department of BSMMU. Methods: The present cross-sectional study was carried out in the Department of Orthodontic, Faculty of Dentistry, BSMMU, over a period 24 months from January 2008 to December 2009. A total of 110 participants who were suffering from malocclusion and came for dental treatment were the study population. Results: The mean age of the patients was 21 years and the youngest and the oldest patients were 8 and 32 years old respectively with female to male ratio being roughly 3:2. Graduate or postgraduate level educated patients were predominant (53.6%. Over 70% of the respondents viewed malocclusion as an aesthetic problem, 50% as functional problem, 55.5% social problem and 69.1% oral problem. Two-third (67% told that malocclusion was a treatable condition. Approximately 43% of the patients identified trauma as a cause of malocclusion, 40% gingivitis or periodontitis and 35.5% dental caries. About one-third (32.7% of the respondents was of the opinion that certain habits should be avoided to prevent malocclusion, 15.5% told timely treatment of malocclusion, 30% told prevention of early loss of teeth due to caries, 12.7% were in favour of the use of a space maintainer in places of premature loss of a deciduous tooth. Over 90% of the respondents held the view that symptoms of malocclusion, its prevention and different treatment options should get the priority in educating the society about malocclusion. However, 80% of the respondents told that causative factors should discussed. Regarding ways of behaviour change
Loebnitz, Natascha; Grunert, Klaus G
Consumer attitudes play an important role in the acceptance of new technologies. The success of food innovations depends on understanding how consumers form and change attitudes toward food technologies. Earlier post hoc explanations suggest that evaluative conditioning can change consumer...... attitudes toward food technologies. The present study tests how evaluative conditioning can affect consumer acceptance of new food technologies. Furthermore, authors investigate whether evaluative conditioning is resistant to extinction after a two-month period and whether the evaluative conditioning effect...... prevails in a product-related context. Within an evaluative conditioning paradigm including between-subjects control groups in addition to standard within-subjects control conditions, participants were presented with three food technologies (conventional, enzyme, and genetic technology) paired...
Beer, T.M.; Armstrong, A.J.; Rathkopf, D.; Loriot, Y.; Sternberg, C.N.; Higano, C.S.; Iversen, P.; Evans, C.P.; Kim, C.S.; Kimura, G.; Miller, K.; Saad, F.; Bjartell, A.S.; Borre, M.; Mulders, P.; Tammela, T.L.; Parli, T.; Sari, S.; Os, S. van; Theeuwes, A.; Tombal, B.
Enzalutamide significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) among men with chemotherapy-naive metastatic castration-resistant prostate cancer at the prespecified interim analysis of PREVAIL, a phase 3, double-blind, randomized study. We evaluated the
Martha Quesada Concepción
Full Text Available Because of blood transfusions are one of the ways of transmitting the immune deficiency syndrome (AIDS/HIV; it constitutes warriness from the epidemiological point of view. A descriptive research was done with the objective of determining the prevailing of sensitive blood driving AIDS/HIV in the Provincial Blood Bank from Sancti Spíritus from January 1 st , 2007 to December 31 st, 2008. The sample was conformed by 312 donants with positive diagnosis to AIDS/HIV. Some variables were used such as prevailing, age, sex, race, home town. The scores of higher prevailing to AIDS/HIV were shown by the male sex (4,42, the 26-33 year old group (1,55; it prevailing volunteer blood driving (81,0 % , and Sancti Spíritus municipality gave more cases (27,5% .Just because sensibility to tests based on antibody, that is why it is important the constant checking of all processes that guarantee blood driving to be sired.
Singh, S.K.; Singh, Anoop; Rai, J.P.N.
The impact of prevailing disturbances in montane habitats of Nanda Devi Biosphere Reserve (NDBR) was studied on soil microbial population, biomass, soil respiration and enzyme activities during wet and dry seasons. The physico-chemical characteristics of soils exhibited conspicuous variation in t...
Fabio Andrés Bonilla Sanabria
Full Text Available Admitting the theory of a company being a set of multiple interests, the first part of this article intends to give an overview of the Shareholder and Stockholders models in the Corporate Social Responsibility debate. The prevailing view in western Company Law (the cases of the UK and US are considered is that of the Shareholder Wealth Maximization model. For the author of the article, events such as the financial crisis showed that the financial conditions of companies giving its‘ extended effects should give way to calls for public accountability in company management. However there seems to be a deadlock given that the prevailing model favours shareholders.In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.
George, Cindy M.
Solution-focused therapy is proposed as an effective strength-based model for children with social phobia. Social phobia is described along with the etiology and prevailing treatment approaches. A case illustration demonstrates the application of solution-focused therapy with a child who experienced social phobia. Implications for counseling and…
Knight, Carolyn; Gitterman, Alex
Clinical or micro intervention predominates in social work education and practice. The prevailing assumption in social work practice and education is that one engages in either micro or macro intervention. In this article, we describe how these interventions may be merged into an integrated whole through social work practice with groups. The…
Cano G, M.A.; Castillo M, L.; Orea T, A.
The Coronary Arterial Illness (EAC) is the first cause of death of those Mexicans. Among their numerous risk factors it highlights the age with more bias starting from the 45 years. The objective of this investigation was to determine the prevailing of ischemic cardiopathy (Cl) and heart attack to the myocardium (IAM) in fellows smaller than 40 years and to identify risk factors. The study of myocardial perfusion (EPM) it is a non invasive study and of great sensibility and specificity that it allows to detect obstructive coronary lesions. The used method was retrospective-traverse Study in 125 patients smaller than 40 years. Files of patients to who EPM had been practiced with Technetium 99m-SESTAMlBI, protocol of one day, were revised, where its were analyzed the short and long axis (vertical and horizontal). General data, somatometry, emotional profile analysis, lipids and glucose profiles were gathered. Results. The population conformed it 53% women and 47% men with average of 31.9 year-old age of corporal mass index (IMC) 25.1 kg/cm 2 . 46% of abnormal studies was obtained, of which 35% was compatible with ischemic cardiopathy (Cl) and 11% with heart attack to the myocardium (IAM). The characteristics of these were: age 31.6±6 Vs 32.6±5.9 years; IMC 25.4±7.0 Vs 24.4±3.34 kg/cm 2 ; stature 161.6±9.8 Vs 165.5±9.7cm; TAS 139.1±29.2 Vs. 115±13.4 mm Hg, TAD 84.5±17.4 Vs. 75±9.4 mm Hg; civil state married 65.5% (p=0.005) Vs single 57%; bigger depression 32% Vs anxiety 28%, in the group of patients with Cl and IAM, respectively. In the IAM population it was found an additional IRC 21% (p=0.030), HAS 21% (p=0.025) and drug addiction 21% (p=0.002). The rest of the results didn't show significant differences. Conclusion: Only 6.5% of the patients that went to EPM- 99m Tc-SESTAMIBl in a 6 year-old lapse, were smaller than 40 years. 71% of them was referred by prechordal pain in who almost the half it was evidenced Cl or IAM. In this investigation besides the
Markovitzky, Omer; Anholt, Gideon E; Lipsitz, Joshua D
Social anxiety occurs in a range of social situations, the salience of which is influenced by prevailing modes of social contact. The emergence of computer mediated communication (CMC), buoyed by the recent explosion of social networks, has changed the way many people make and maintain social contacts. We randomly assigned 30 socially anxious and 30 low social anxiety participants to a brief internet chat introduction or a control internet surfing condition followed by a standardized face to face (FTF) interaction. We hypothesized that for socially anxious participants the chat introduction would reduce anxiety of and preference to avoid the subsequent FTF interaction. Results supported hypotheses for most indices. Findings suggest that, at least for the common situation in which internet chat precedes FTF interaction with the same person, such contact may reduce social anxiety. It is not known whether this decrease would generalize to FTF contact in other contexts. It is suggested that CMC might be construed as a particularly useful form of safety behavior that may help in the allocation of attentional resources to process new information relevant for disconfirmation of negative beliefs maintaining social anxiety. Potential clinical implications are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.
Self-presentational descriptions such as self-enhancement and modesty are embedded in a social context. Therefore, when applied improperly they may lead to an erroneous or an unfavorable impression. In this study, participants evaluated the likeability and the competence of a self-presenting partner
Full Text Available Intensive development of socialist society, which started immediately after Second World War, proceeded simultaneously on two mutually conditional tracks: on material and ideological. In certain way, both were based on the critique of traditional social concept: starting from its economic and all the way to value characteristics under all encompassing parole of "modernization". The policy of transformation was mostly based on certain number of dichotomies that expressed the difference between past and preferred social forms and contents. Past, which was defined as old, regressive, conservative, patriarchal, alienated should be replaced by preferred, that is, by new, progressive, modern, egalitarian, democratic, free... The mainstay of the past was village, agrarian family, while the mainstay of the preferred was, as it appeared later, urban type family. Modernization implied economic restructuring of the state through the process of intensive industrialization and consequently, urbanization while "non-material" discourse of changes was dominated by the idea of democratization of society, that is, a specific ideology of "freedom" that had to be won on all instances of social reality. In-alienation of society was proclaimed as the highest ideal of the new order, which should be achieved by the emancipation of its members from all types of coercion-from work, through moral and up to religious coercion. Even though there is a prevailing viewpoint in scientific literature about the conditionality of social transformations by economic and technological factors and "progress", I think that it can be rightly said that this process was primarily of "spiritual" nature, that is, that its main mover and trigger was the process of atheism of the society. Development of modern society (not only in Serbia meant in fact its de-Christianization and secularization, where "freedom" from God and "coercions" contained in the religious view of the world became
Mitsuya, Hironori; Omata, Naoto; Kiyono, Yasushi; Mizuno, Tomoyuki; Murata, Tetsuhito; Mita, Kayo; Okazawa, Hidehiko; Wada, Yuji
Nutritional and social environmental problems during the early stages of life are closely associated with the pathophysiology of mood disorders such as depression. Disruption or dysfunction of the central norepinephrine (NE) system is also considered to play a role in mood disorders. Therefore, we evaluated the effects of zinc deficiency and/or social isolation on mood and changes in the central NE system using rats. Compared with the controls, the rats subjected to zinc deficiency or social isolation alone exhibited increased anxiety-related behavior in the elevated plus maze and greater depression-like behavior in the forced swim test. However, the co-occurrence of zinc deficiency and social isolation resulted in decreased anxiety-related behavior and control levels of depression-like behavior. Social isolation alone decreased the rats' cerebral NE concentrations. The expression of the NE transporter was not affected by social isolation alone, but its expression in the locus coeruleus was markedly decreased by the co-occurrence of social isolation and zinc deficiency, and this change was accompanied by an increase in the blood concentration of 3-methoxy-4-hydroxyphenylglycol, which is a marker of central NE system activity. These findings suggest that zinc deficiency or social isolation alone induce anxious or depressive symptoms, but the presence of both conditions has anxiolytic or antidepressive effects. Furthermore, these opposing effects of mood-related behaviors were found to be associated with changes in the central NE system. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
Social memory plays a pivotal role in social behaviors, from mating behaviors to cooperative behaviors based on reciprocal altruism. More specifically, social/person recognition memory is supposed, by behavioral-economic and game-theoretic analysis, to be required for tit- for-tat like cooperative behaviors to evolve under the N-person iterated prisoner fs dilemma game condition. Meanwhile, humans are known to show a social stress response during face-to-face social interactions, which might ...
José van Dijck; Thomas Poell
Over the past decade, social media platforms have penetrated deeply into the mechanics of everyday life, affecting people's informal interactions, as well as institutional structures and professional routines. Far from being neutral platforms for everyone, social media have changed the conditions and rules of social interaction. In this article, we examine the intricate dynamic between social media platforms, mass media, users, and social institutions by calling attention to social media log...
Freeman, James V; Hutton, David W; Barnes, Geoffrey D; Zhu, Ruo P; Owens, Douglas K; Garber, Alan M; Go, Alan S; Hlatky, Mark A; Heidenreich, Paul A; Wang, Paul J; Al-Ahmad, Amin; Turakhia, Mintu P
Randomized trials of left atrial appendage (LAA) closure with the Watchman device have shown varying results, and its cost effectiveness compared with anticoagulation has not been evaluated using all available contemporary trial data. We used a Markov decision model to estimate lifetime quality-adjusted survival, costs, and cost effectiveness of LAA closure with Watchman, compared directly with warfarin and indirectly with dabigatran, using data from the long-term (mean 3.8 year) follow-up of Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation (PROTECT AF) and Prospective Randomized Evaluation of the Watchman LAA Closure Device in Patients With Atrial Fibrillation (PREVAIL) randomized trials. Using data from PROTECT AF, the incremental cost-effectiveness ratios compared with warfarin and dabigatran were $20 486 and $23 422 per quality-adjusted life year, respectively. Using data from PREVAIL, LAA closure was dominated by warfarin and dabigatran, meaning that it was less effective (8.44, 8.54, and 8.59 quality-adjusted life years, respectively) and more costly. At a willingness-to-pay threshold of $50 000 per quality-adjusted life year, LAA closure was cost effective 90% and 9% of the time under PROTECT AF and PREVAIL assumptions, respectively. These results were sensitive to the rates of ischemic stroke and intracranial hemorrhage for LAA closure and medical anticoagulation. Using data from the PROTECT AF trial, LAA closure with the Watchman device was cost effective; using PREVAIL trial data, Watchman was more costly and less effective than warfarin and dabigatran. PROTECT AF enrolled more patients and has substantially longer follow-up time, allowing greater statistical certainty with the cost-effectiveness results. However, longer-term trial results and postmarketing surveillance of major adverse events will be vital to determining the value of the Watchman in clinical
Watanabe, Yusuke; Hayashida, Kentaro; Takayama, Morimasa; Mitsudo, Kazuaki; Nanto, Shinsuke; Takanashi, Shuichiro; Komiya, Tatsuhiko; Kuratani, Toru; Tobaru, Tetsuya; Goto, Tsuyoshi; Lefèvre, Thierry; Sawa, Yoshiki; Morice, Marie-Claude
The efficacy and safety of transcatheter aortic valve implantation (TAVI) in Asian populations were unknown. The purpose of this study was to compare directly the clinical outcomes of the first Japanese trial and a European single-center experience after TAVI. Between April 2010 and October 2011, 64 patients were included in the PREVAIL JAPAN multicenter trial which was set up to evaluate the safety and efficacy of the Edwards SAPIEN XT™ (Edwards Lifesciences, Irvine, CA, USA) in high-risk Japanese patients with severe aortic stenosis. Between March 2010 and January 2012, 237 consecutive patients treated with TAVI using the Edwards SAPIEN XT™ prosthesis at Institut Cardiovasculaire Paris Sud were prospectively included in the Massy cohort. We compared the clinical outcomes of these two cohorts. Patients were of similar age (83.4±6.6 years vs. 84.5±6.1 years, p=0.25), but logistic EuroSCORE was higher in the Massy cohort (20.2±11.7% vs. 15.6±8.0%, pPREVAIL JAPAN cohort (1.41±0.14m(2) vs. 1.72±0.18m(2); pPREVAIL JAPAN cohort (12.7±11.4mmHg vs. 10.1±3.6mmHg, p=0.01), but satisfactory improvement in 6-month functional status was obtained in both cohorts (76.5% vs. 77.2%, p=0.91). Clinical outcomes after TAVI in the patients included in the PREVAIL JAPAN trial were acceptable and as safe as that of a single-center European cohort. Copyright © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Freeman, James V.; Hutton, David W.; Barnes, Geoffrey D.; Zhu, Ruo P.; Owens, Douglas K.; Garber, Alan M.; Go, Alan S.; Hlatky, Mark A.; Heidenreich, Paul A.; Wang, Paul J.; Al-Ahmad, Amin; Turakhia, Mintu P.
Background Randomized trials of left atrial appendage (LAA) closure with the Watchman device have shown varying results, and its cost-effectiveness compared to anticoagulation has not been evaluated using all available contemporary trial data. Methods and Results We used a Markov decision model to estimate lifetime quality-adjusted survival, costs, and cost-effectiveness of LAA closure with Watchman, compared directly with warfarin and indirectly with dabigatran, using data from the long-term (mean 3.8 year) follow-up of PROTECT AF and PREVAIL randomized trials. Using data from PROTECT AF, the incremental cost-effectiveness ratios (ICER) compared to warfarin and dabigatran were $20,486 and $23,422 per quality adjusted life year (QALY), respectively. Using data from PREVAIL, LAA closure was dominated by warfarin and dabigatran, meaning that it was less effective (8.44, 8.54, and 8.59 QALYs, respectively) and more costly. At a willingness-to-pay-threshold of $50,000 per QALY, LAA closure was cost-effective 90% and 9% of the time under PROTECT AF and PREVAIL assumptions, respectively. These results were sensitive to the rates of ischemic stroke and intracranial hemorrhage for LAA closure and medical anticoagulation. Conclusions Using data from the PROTECT AF trial, LAA closure with the Watchman device was cost-effective; using PREVAIL trial data, Watchman was more costly and less effective than warfarin and dabigatran. PROTECT AF enrolled more patients and has substantially longer follow-up time, allowing greater statistical certainty with the cost-effectiveness results. However, longer term trial results and post-marketing surveillance of major adverse events will be vital to determining the value of the Watchman in clinical practice. PMID:27307517
Rudy M. Schuster; David Cole; Troy Hall; Jennifer Baker; Rebecca Oreskes
Purposes were to describe on-site social carrying capacity from the users' perspectives, provide management applications, and refi ne constructs of product shift and rationalization used by visitors as coping responses to crowding. Data were gathered using on-site exit surveys of hikers in the Great Gulf Wilderness and analyzed with descriptive statistics,...
Beer, Tomasz M; Armstrong, Andrew J; Rathkopf, Dana; Loriot, Yohann; Sternberg, Cora N; Higano, Celestia S; Iversen, Peter; Evans, Christopher P; Kim, Choung-Soo; Kimura, Go; Miller, Kurt; Saad, Fred; Bjartell, Anders S; Borre, Michael; Mulders, Peter; Tammela, Teuvo L; Parli, Teresa; Sari, Suha; van Os, Steve; Theeuwes, Ad; Tombal, Bertrand
Enzalutamide significantly improved radiographic progression-free survival (rPFS) and overall survival (OS) among men with chemotherapy-naïve metastatic castration-resistant prostate cancer at the prespecified interim analysis of PREVAIL, a phase 3, double-blind, randomized study. We evaluated the longer-term efficacy and safety of enzalutamide up to the prespecified number of deaths in the final analysis, which included an additional 20 mo of follow-up for investigator-assessed rPFS, 9 mo of follow-up for OS, and 4 mo of follow-up for safety. Enzalutamide reduced the risk of radiographic progression or death by 68% (hazard ratio [HR] 0.32, 95% confidence interval [CI] 0.28-0.37; pPREVAIL provides more complete assessment of the clinical benefit of enzalutamide. PREVAIL is registered on ClinicalTrials.gov as NCT01212991. According to data from longer follow-up, enzalutamide continued to provide benefit over placebo in patients with metastatic castration-resistant prostate cancer. Copyright © 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Svendsen, Gunnar Lind Haase; Svendsen, Gert Tinggaard
The Scandinavian welfare model is a puzzle to economists: It works economically, even though free-riding should prevail with its explosive cocktail of high taxation and high social benefits. One overlooked solution to the puzzle could be the unique stock of social trust present in Scandinavia. Here......, the four Scandinavian countries (Norway, Denmark, Sweden, and Finland) form the top three with scores above 60 percent social trust on a ranking that covers 94 countries from all over the world....
Austin,James; Stevenson,Howard; Wei-Skillern,Jane
Entrepreneurship has been the engine propelling much of the growth of the business sector as well as a driving force behind the rapid expansion of the social sector. This article offers a comparative analysis of commercial and social entrepreneurship using a prevailing analytical model from commercial entrepreneurship. The analysis highlights key similarities and differences between these two forms of entrepreneurship and presents a framework on how to approach the social entrepreneurial proc...
Bandelow, B; Wedekind, D
With a lifetime prevalence of 13% social phobia (social anxiety disorder) is a common and serious condition that should not be played down because of the burden associated with the disorder, an increased suicide rate and the frequent comorbidity with substance abuse disorders. Social phobia is characterized by the excessive and unrealistic fear of being scrutinized or criticized by others. The disorder often begins in adolescence.Symptoms of social phobia can be effectively treated with evidence-based treatment, including cognitive behavior therapy (CBT) and psychopharmacological medications. In the present paper, treatment recommendations are given, which are based on a systematic review of all available randomized trials for the treatment of social phobia. Among psychological therapies, variants of CBT have been proven to be effective in controlled studies. Selective serotonin reuptake inhibitors (SSRIs) and the selective serotonin norepinephrine reuptake inhibitor (SNRI) venlafaxine are among the drugs of first choice.
Nuria Sánches Madrid
Full Text Available This paper aims at shedding light on an obscure point in Kant's theory of the state. It discusses whether Kant's rational theory of the state recognises the fact that certain exceptional social situations, such as the extreme poverty of some parts of the population, could request institutional state support in order to guarantee the attainment of a minimum threshold of civil independence. It has three aims: 1 to show that Kant's Doctrine of Right can offer solutions for the complex relation between economics and politics in our present time; 2 to demonstrate the claim that Kant embraces a pragmatic standpoint when he tackles the social concerns of the state, and so to refute the idea that he argues for an abstract conception of politics; and 3 to suggest that a non-paternalistic theory of rights is not necessarily incompatible with the basic tenets of a welfare state.
Jorge Roberto, Volpentesta
Full Text Available The research proposed as general objective to increase knowledge about the characteristics of the actions that companies make in Corporate Social Responsibility programs with interested groups (stakeholders who are in the community or society, from an organizational perspective, trying to clarify what are the causes and / or circumstances that determine and explain the design of such diverse activities ranging from those characterized by a central dirigisme proper implementation of business logic and in which you work from a desk to the other, to those from its inception involve and engage the recipients of those actions generate real actions with others.Interest in this knowledge is based on more and more companies are taking action or intervention programs in the social field, but not always effective considering the social impact. To analyze the processes involved, the organizational circumstances, structural causes and procedural logic that prevail in the design of these actions can help appraise, a priori, their effectiveness and potential outcomes, facilitating the development of a possible model for guidance on the fundamentals needed to conduct successful social interventions.
Kravtsova, E.M.; Kravtsova, O.S.
The development of computerized informational-analytical system is started with the purpose to organize monitoring and to estimate radiation effect on population residing in the zone affected by MPA (1992). The data base includes a special information block containing social-economic characteristics. A specific feature of the method used to create the data base is the focus on the family connections. Currently the block meant for registration of environmental monitoring, in residential areas around Mayak plants has been developed most completely
Full Text Available The article considers the review of approaches for the creation of a new social paradigm in the health care system management based on the principles of humanism. The paradigms are based on responsible partnership and person-oriented approach. Major principles of the paradigm’s creation are given in details, as well as their expected impact on implementing reforms in the health care management of Ukraine.
Full Text Available Demographic interest in the explanations of the first fertility transition has receded considerably during the last decade. Despite the empirical evidence of global convergence in fertility, there is still no consensus on the factors which explain the swiftness of the change in some contexts and its deceleration in some others. From the policy perspective, it remains pivotal to locate the factors that affect the momentum of fertility transition. In this essay the fast decline to below replacement-level period Total Fertility Rate in South India will be examined as an example of fertility transition despite slow social and/or economic development. The analysis is based on a literature review of empirical studies on the determinants of regional fertility differentials in India. Some southern states, most particularly Andhra Pradesh, manifest below replacement-level fertility (TFR 1.79 despite low average age at marriage even in Indian terms, the resilience of womens universal marriage, and heavy reliance on a terminal family planning method, female sterilization. The case of Andhra Pradesh shows that below-replacement level fertility can occur despite slow social development, widespread poverty and gender asymmetries. Geographical and social diffusion effects are partly responsible of the speed of the decline, although they are difficult to measure or test in the level of fertility decision-making.
Full Text Available The purpose of the current paper is to test whether value similarity may foster social trust in society and whether people have higher levels of social trust when they emphasise the same values that prevail in their country. The relationship between social trust and human values was examined in a sample of 51,308 people across 29 European countries using data from the European Social Survey round 6. Results suggest that value similarity is more important in generating individual level social trust in countries where the overall levels of social trust are higher. There is a stronger positive relationship between value similarity and social trust in Scandinavian countries, which have high social trust levels, while in countries with a low level of social trust, congruity of the personal value structure with the country level value structure tends to decrease the individuals trustfulness
Ivy Corazon B. Panelo
Full Text Available The study aimed to analyze the Passion for Philippine Social Transformation in the Novel Ilustrado of Miguel Syjuco. In view of the prevailing social problems encountered in the Philippines such as social injustices, corruption, and the like, and the need for transformation or change of its societal structures, the researcher’s interest being a literature teacher is aroused or stimulated. The qualitative approach was used in this descriptive study of the novel of socio-political nature in order to project a social transformation through critical investigation on the values projected in it. Hence, the study used analytical approach, psychological approach, philosophical or moral/ethical approach, and sociological approach in analyzing its content. Results showed that social transformation in making wise preferences, having smooth family relationship, and decreasing social injustices apparently were the social transformations depicted in the novel. The author’s rejection to join politics and desiring to expose social ills were the major incidents in his life that showed his passion for social change. The structures of the society that needed to be changed were moral values of the leaders, personal interests, Filipinos culture, and the motives of the politicians to maintain their hold in power. The use of symbolism as the predominant literary device gave the readers clearer picture of the condition of the society and understanding of the author’s passion for Philippine social transformation. The moral ethical values of courage in saving other’s lives from devastation, honesty to self and to the country, devotion to Filipino writings and writers, faith in God, and forgiveness reflected in the story were made alive and real in the readers.
Effect of social mobility in family financial situation and housing tenure on mental health conditions among South Australian adults: results from a population health surveillance system, 2009 to 2011.
Dal Grande, Eleonora; Chittleborough, Catherine R; Wu, Jing; Shi, Zumin; Goldney, Robert D; Taylor, Anne W
To assess the association of socioeconomic position (SEP), measured by family financial situation and housing tenure in childhood and adulthood, with mental health conditions in adulthood. Representative cross-sectional population data were collected using a risk factor surveillance system in South Australia, Australia. Each month, a random sample were selected from the Electronic White Pages. Participants aged 25 years and above (n = 10429) were asked about doctor diagnosed anxiety, stress or depression, suicidal ideation, psychological distress, demographic and socioeconomic factors using Computer Assisted Telephone Interviewing (CATI). Social mobility measures were derived from housing status and perceived financial situation during adulthood and at 10 years of age. The prevalence of psychological distress was 8.1 %, current diagnosed mental health condition was 14.8 % and suicidal ideation was 4.3 %. Upward mobility in family financial situation and housing tenure was experienced by 28.6 % and 19.3 %, of respondents respectively. Downward mobility was experienced by 9.4 % for housing tenure and 11.3 % for family financial situation. In the multivariable analysis, after adjusting for age, sex, childhood family structure and adult education, downward social mobility and stable low SEP (both childhood and adulthood), in terms of both housing tenure and financial situation, were positively associated with all three mental health conditions. People with low SEP in adulthood had poor mental health outcomes regardless of their socioeconomic circumstances in childhood. Policies to improve SEP have the potential to reduce mental health conditions in the population.
Full Text Available Social Dominance Theory (Sidanius & Pratto, 1999 stress that systematic inter group discrimination is related to social ideologies that contribute to coordinate institutions and individuals behaviors. The acceptance of inequity legitimating ideologies is partially determined for individuals general desire of group based domination. This desire is captured by Social Orientation Domination construct -SDO. Pursuing the objective of exploring SDO levels and its relationship with variables such ideological positioning and values, a descriptive correlation study, with a non experimental design, was carried out based on a convenience sample composed by 254 college students from Buenos Aires city surroundings . Results show that SDO is positively associated with Power and Achievement values and negatively with Benevolence and Universalism. SDO is stronger in participants right side ideologically positioned. Participants show a low SDO, emphasize self- trascendence and openness to change values and tend to a left side ideological positioning. Age, participant’s quality of “students” and prevailed career orientation can be seen as factors conditioning a more hierarchies attenuating believes and behaviors.
Matzat, U.; Vrieling, E. M.
Research on the educational consequences of social media has led to divergent findings that are difficult to integrate and studies often examine specific courses. It remains unclear what types of social media use in classroom prevail on a broader scale and how teachers, if at all, can affect outcomes. We contribute to answering these questions by…
Loohuis, Raymond Petrus Antonius; Groen, Arend J.; von Raesfeld Meijer, Ariane M.; Hutschemaekers, B.
How, why, and under what conditions can social movements contribute to the development of social entrepreneurial process developed by embedded actors? Social entrepreneurship scholars are increasingly adopting social movement theories to explain how individual entrepreneurs develop their social
Breno de Paula Andrade Cruz
Full Text Available Purpose – Based on Corporate Social Responsibility (CSR aspects, Social Boycott is presented in this paper as an amplification of the Labor Boycott concept. Design/methodology/approach – A statistical experiment with 240 individuals has been carried out, so that it could verify if consumers’ perceptions related to the Management Context of Corporate Social Responsibility (MCCSR of the fictitious Alpha company has considerable impact on the variable Boycott Efficacy (BE, and on the Boycott Intention (BI. The ANOVA has been used to show causeeffect variable relationship. Findings – MCCSR impacts on BE (H1 and BI (H2. Thus, the Social Consumer’s boycott motivation is driven by the perception of the level of CSR management orientation a company has (anti-corruption internal measures, organizational climate, labor conditions and waste management during production process. While Labor Boycott restricts its analysis to labor conditions, the concept of Social Boycott incorporates all CSR aspects. Originality/value – This study presents Social Boycott definition and its insertion on consumer boycott literature - types of boycott and boycott motivations (ideological dimension. Thus, tangential analysis such as experiential dimension and a theoretical political boycott gap are discussed.
Bourdais-Mannone, Claire; Cherikh, Faredj; Gicquel, Nathalie; Gelsi, Eve; Jove, Frédérique; Staccini, Pascal
The purpose of this study was to conduct a descriptive and comparative analysis of the tools used by healthcare professionals specializing in addictive disorders to promote a rapprochement of information systems. The evaluation guide used to assess the compensation needs of disabled persons treated in "Maisons Départementales des Personnes Handicapées" (centres for disabled people) organizes information in different areas, including a psychological component. The guide includes social and environmental information in the "Recueil Commun sur les Addictions et les Prises en charges" (Joint Report on Drug Addiction and Drug Treatment). While the program for the medicalization of information systems includes care data, the current information about social situations remains inadequate. The international classification of diseases provides synthetic diagnostic codes to describe substance use, etiologic factors and the somatic and psychological complications inherent to addictive disorders. The current system could be radically simplified and harmonized and would benefit from adopting a more individualized approach to non-substance behavioral addictions. The international classification of disabilities provides tools for evaluating the psychological component included in the recent definition of addictive disorders. Legal information should play an integral role in the structure of the information system and in international classifications. The prevalence of episodes of care and treatment of addictive and psychological disorders was assessed at Nice University Hospital in all disciplines. Except in addiction treatment units, very few patients were found to have a RECAP file.
Schwartz, L A; Tuchman, L K; Hobbie, W L; Ginsberg, J P
Policy and research related to transition to adult care for adolescents and young adults (AYAs) has focused primarily on patient age, disease skills and knowledge. In an effort to broaden conceptualization of transition and move beyond isolated patient variables, a new social-ecological model of AYA readiness for transition (SMART) was developed. SMART development was informed by related theories, literature, expert opinion and pilot data collection using a questionnaire developed to assess provider report of SMART components with 100 consecutive patients in a childhood cancer survivorship clinic. The literature, expert opinion and pilot data collection support the relevance of SMART components and a social-ecological conceptualization of transition. Provider report revealed that many components, representing more than age, disease knowledge and skills, related to provider plans for transferring patients. SMART consists of inter-related constructs of patients, parents and providers with emphasis on variables amenable to intervention. Results support SMART's broadened conceptualization of transition readiness and need for assessment of multiple stakeholders' perspectives of patient transition readiness. A companion measure of SMART, which will be able to be completed by patients, parents and providers, will be developed to target areas of intervention to facilitate optimal transition readiness. Similar research programmes to establish evidence-based transition measures and interventions are needed. © 2011 Blackwell Publishing Ltd.
Alumkal, Joshi J; Chowdhury, Simon; Loriot, Yohann; Sternberg, Cora N; de Bono, Johann S; Tombal, Bertrand; Carles, Joan; Flaig, Thomas W; Dorff, Tanya B; Phung, De; Forer, David; Noonberg, Sarah B; Mansbach, Hank; Beer, Tomasz M; Higano, Celestia S
The Multinational Phase 3, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Oral MDV3100 in Chemotherapy-Naive Patients With Progressive Metastatic Prostate Cancer Who Have Failed Androgen Deprivation Therapy (PREVAIL) trial was unique as it included patients with visceral disease. This analysis was designed to describe outcomes for the subgroup of men from PREVAIL with specific sites of visceral disease to help clinicians understand how these patients responded to enzalutamide prior to chemotherapy. Prespecified analyses examined the coprimary endpoints of radiographic progression-free survival (rPFS) and overall survival (OS) only. All other efficacy analyses were post hoc. The visceral subgroup was divided into liver or lung subsets. Patients with both liver and lung metastases were included in the liver subset. Of the 1717 patients in PREVAIL, 204 (12%) had visceral metastases at screening (liver only or liver/lung metastases, n = 74; lung only metastases, n = 130). In patients with liver metastases, enzalutamide was associated with an improvement in rPFS (hazard ratio [HR], 0.44; 95% confidence interval [CI], 0.22-0.90) but not OS (HR, 1.04; 95% CI, 0.57-1.87). In patients with lung metastases only, the HR for rPFS (0.14; 95% CI, 0.06-0.36) and the HR for OS (0.59; 95% CI, 0.33-1.06) favored enzalutamide over placebo. Patients with liver metastases had worse outcomes than those with lung metastases, regardless of treatment. Enzalutamide was well tolerated in patients with visceral disease. Enzalutamide is an active first-line treatment option for men with asymptomatic or mildly symptomatic chemotherapy-naive metastatic castration-resistant prostate cancer and visceral disease. Patients with lung-only disease fared better than patients with liver disease, regardless of treatment. Copyright © 2017 Elsevier Inc. All rights reserved.
Chapman, M J; Orsoni, A; Robillard, P; Hounslow, N; Sponseller, C A; Giral, P
Statin treatment may impair glucose homeostasis and increase the risk of new-onset diabetes mellitus, although this may depend on the statin, dose and patient population. We evaluated the effects of pitavastatin 4 mg/day on glucose homeostasis in patients with metabolic syndrome in the CAPITAIN trial. Findings were validated in a subset of patients enrolled in PREVAIL-US. Participants with a well defined metabolic syndrome phenotype were recruited to CAPITAIN to reduce the influence of confounding factors. Validation and comparison datasets were selected comprising phenotypically similar subsets of individuals enrolled in PREVAIL-US and treated with pitavastatin or pravastatin, respectively. Mean change from baseline in parameters of glucose homeostasis (fasting plasma glucose [FPG], glycated hemoglobin [HbA1c], insulin, quantitative insulin-sensitivity check index [QUICKI] and homeostasis model of assessment-insulin resistance [HOMA-IR]) and plasma lipid profile were assessed at 6 months (CAPITAIN) and 3 months (PREVAIL-US) after initiating treatment. In CAPITAIN (n = 12), no significant differences from baseline in HbA1c, insulin, HOMA-IR and QUICKI were observed at day 180 in patients treated with pitavastatin. A small (4%) increase in FPG from baseline to day 180 (P 0.05). Similar results were observed for pravastatin in the comparison dataset (n = 14). Other than a small change in FPG in the CAPITAIN study, neutral effects of pitavastatin on glucose homeostasis were observed in two cohorts of patients with metabolic syndrome, independent of its efficacy in reducing levels of atherogenic lipoproteins. The small number of patients and relatively short follow-up period represent limitations of the study. Nevertheless, these data suggest that statin-induced diabetogenesis may not represent a class effect.
Bouckaert, J.M.C.; Degryse, H.A.
We offer a social-welfare comparison of the two most prominent default options – opt in and opt out – using a two-period model of localized competition. We demonstrate that when consumers stick to the default option, the prevailing default policy shapes firms' ability to collect and use customer
Barakova, E.I.; Feijs, L.; Kyffin, S.; Young, B.
The human brain has evolved for governing motor activity by transforming sensory patterns to patterns of motor coordination. Movement, as a basic bodily expression of this governing function is shown to underlie higher cognitive processes and social interaction.There are three prevailing concepts of
The study was prompted by the on - going discourse on the appropriateness of existing social welfare delivery mechanisms in the Third World which, over time, have tended to be informed by the modernization approach. The prevailing view, particularly among academics and practitioners in Africa, is essentially that the ...
McLeod, Jane D.
Evaluates the contribution of social experiences to homogamy for anxiety disorders, major depression, and alcohol or drug dependence. Five prevailing explanations for observed homogamy are evaluated: (1) primary assortive mating; (2) secondary assortive mating; (3) similarity resulting from shared experiences; (4) increasing similarity through…
Serbin, Lisa A.; Temcheff, Caroline E.; Cooperman, Jessica M.; Stack, Dale M.; Ledingham, Jane; Schwartzman, Alex E.
This 30-year longitudinal study examined pathways from problematic childhood behavior patterns to future disadvantaged conditions for family environment and child rearing in adulthood. Participants were mothers (n = 328) and fathers (n = 222) with lower income backgrounds participating in the ongoing Concordia Longitudinal Risk Project. Structural…
-age respondents. The data were analyzed using the IBM SPSS22 (logistic regression was used to assess the effect of the variables on poor SRH). Such variables as, socio-economic status, economic activity, work conditions were created by using principal component analysis.A binomial logistic regression...
Juracy Ignez Assmann Saraiva
Full Text Available Resultados de pesquisas de diferentes órgãos que avaliam o desenvolvimento de nosso país ou que detalham a competência leitora dos brasileiros permitem afirmar que há uma correlação entre aspectos da conjuntura econômico-social e o domínio da leitura. Essacorrelação aponta para a necessidade de mudanças que visualizem a educação, alicerçada na leitura e na experiência estética, como o caminho para a humanização dos indivíduos, da qual decorre o verdadeiro desenvolvimento social. Todavia, para que esse objetivo seja alcançado, sendo redesenhada a face da realidade brasileira, é imprescindível que se proceda ao enfrentamento da crise cultural que interfere negativamente na formação de leitores e que é responsável pelo desprestígio do texto literário como espaço de aprendizagem e deconhecimento.Results of surveys from different agencies which evaluate thedevelopment of our country or which detail the reading competence of Brazilians allow us to say that there is a correlation between aspects of socioeconomic conjuncture and the mastering of reading. This correlation points to the necessity of changes which considereducation as based on reading and aesthetic experience as the way for the humanization of the persons from which springs out the true social development. However, in order to achieve this goal, having redefined the face of Brazilian reality, it is indispensable to proceed to face the cultural crisis which interferes negatively in the formation of readers and which is responsible for the disreputability of the literary text as an opportunity of learning andknowledge.
Daud@Fhiri Nur Suriaty
Full Text Available The purpose of this article is to explore the various discussion of social entrepreneurship. Social entrepreneurship provides a unique opportunity and assumptions to question, challenge and rethink from different perspective of management and business research. This article offers a comparative analysis of commercial entrepreneurship and social entrepreneurship using a prevailing analytical model from commercial entrepreneurship. The analysis highlights key differences and similarities between commercial entrepreneurship and social entrepreneurship. This article also presents a framework on how to approach the social entrepreneurial process more effectively and systematically. Social entrepreneurship is a process of creating value by combining resources in new concepts. These process are intended primarily to get the opportunities to create social value by stimulating social change or achieve social needs. When viewed as a process, social entrepreneurship involves the offering of products and services but can also refer to the creation of new organizations. This article focuses and analyses the literature finding of social entrepreneurship.
Wang, Kejing; Zhang, Yuan; An, Youzhi; Jing, Zhuoxin; Wang, Chao
With the fast urbanization process, how does the vegetation environment change in one of the most economically developed metropolis, Shanghai in East China? To answer this question, there is a pressing demand to explore the non-stationary relationship between socio-economic conditions and vegetation across Shanghai. In this study, environmental data on vegetation cover, the Normalized Difference Vegetation Index (NDVI) derived from MODIS imagery in 2003 were integrated with socio-economic data to reflect the city's vegetative conditions at the census block group level. To explore regional variations in the relationship of vegetation and socio-economic conditions, Ordinary Least Squares (OLS) and Geographically Weighted Regression (GWR) models were applied to characterize mean NDVI against three independent socio-economic variables, an urban land use ratio, Gross Domestic Product (GDP) and population density. The study results show that a considerable distinctive spatial variation exists in the relationship for each model. The GWR model has superior effects and higher precision than the OLS model at the census block group scale. So, it is more suitable to account for local effects and geographical variations. This study also indicates that unreasonable excessive urbanization, together with non-sustainable economic development, has a negative influence of vegetation vigor for some neighborhoods in Shanghai.
Condiciones para el acceso universal a la salud en América Latina: derechos sociales, protección social y restricciones financieras y políticas Conditions for universal access to health in Latin America: social rights, social protection and financial and political constraints
Full Text Available Tras una sucinta problematización de la equidad en salud, sus determinantes sociales y sectoriales, se analizan aspectos macroeconómicos del comportamiento reciente del gasto en salud en la región. Dadas las importantes tensiones contemporáneas respecto de los derechos y la definición de prestaciones de salud, se tratan tres experiencias emblemáticas, de sistemas de salud muy diversos: Chile, Colombia y México. Ellas abarcan distintos aspectos: la garantía de las prestaciones, la reducción de formas de racionamiento implícitas y/o de barreras de entrada, o bien aspectos de calidad.After a brief review of the concept of health equity and its social and sectoral determinants, some macroeconomic aspects of health expenditure in Latin America are considered. Given the significant contemporary tensions with regard to social rights and the definition of health benefits, three emblematic experiences are analyzed in very different health systems, namely those of Chile, Colombia and Mexico. They cover different aspects, such as the guarantee of health benefits, the reduction of forms of implicit rationing and/or barriers to admission, and also aspects related to the quality of services.
Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Social Phobia is a condition characterized by a marked and persistent fear of social or performance situations in which embarrassment may occur. Exposure to the social or performance situation almost invariably provokes an immediate anxiety response. Although adolescents and adults with this disorder recognize that their fear is excessive or unreasonable, this may not be the case in children. Most often, the social or performance situation is avoided, although it is sometimes endured with dread. In individuals younger than 18, symptoms must have persisted for at least 6 months before is disorder is diagnosed. This diagnosis should not be given if the fear is reasonable given the context of the stimuli (e.g., fear of being called on in class when unprepared. The disturbance must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. This disorder is not due to a medical condition, medication, or abused substance. It is not better accounted for by another mental disorder.
Vinograd, S. P.
Scientific literature which deals with the study of human behavior and crew interaction in situations simulating long term space flight is summarized and organized. A bibliography of all the pertinent U.S. literature available is included, along with definitions of the behavioral characteristics terms employed. The summarized studies are analyzed according to behavioral factors and environmental conditions. The analysis consist of two matrices. (1) The matrix of factors studied correlates each research study area and individual study with the behavioral factors that were investigated in the study. (2) The matrix of conclusions identifies those studies whose investigators appeared to draw specific conclusions concerning questions of importance to NASA.
Full Text Available Social movements emerge as part of and in response to the prevailing relations of power. They emerge to make visible identities rendered invisible, abnormal or excluded by these relationships, to challenge currently dominant ideas as to how society should be organized, to draw attention to needs not currently attended to under existing social arrangements, or to argue that existing arrangements need protecting and deepening. The scholars agree that relatively few social movements emerge specifically around the issue of poverty, in particularly poverty as defined by lack. However, if poverty is a product of prevailing relations of power, to the extent that different movements emerge to challenge or deepen these relations, then social movements are necessarily relevant to the existing status of poverty and the likelihood that it may change.
Ballaud, Flore; Dufresne, Alexis; Francez, André-Jean; Colombet, Jonathan; Sime-Ngando, Télesphore; Quaiser, Achim
Viruses impact microbial activity and carbon cycling in various environments, but their diversity and ecological importance in Sphagnum-peatlands are unknown. Abundances of viral particles and prokaryotes were monitored bi-monthly at a fen and a bog at two different layers of the peat surface. Viral particle abundance ranged from 1.7 x 10(6) to 5.6 x 10(8) particles mL(-1), and did not differ between fen and bog but showed seasonal fluctuations. These fluctuations were positively correlated with prokaryote abundance and dissolved organic carbon, and negatively correlated with water-table height and dissolved oxygen. Using shotgun metagenomics we observed a shift in viral diversity between winter/spring and summer/autumn, indicating a seasonal succession of viral communities, mainly driven by weather-related environmental changes. Based on the seasonal asynchrony between viral and microbial diversity, we hypothesize a seasonal shift in the active microbial communities associated with a shift from lysogenic to lytic lifestyles. Our results suggest that temporal variations of environmental conditions rather than current habitat differences control the dynamics of virus-host interactions in Sphagnum-dominated peatlands.
Lidwall, Ulrik; Marklund, Staffan
The aim of the study was to investigate the relevance of the demand-control model and social support in predicting long-term sickness absence (LTSA). Identifying gender- and sector- (private vs. public) specific patterns was in focus. The study uses a cross-sectional design with a case and a control group. The cases are a sample of 2 327 long-term sick listed (>60 days) and the controls are a Swedish population-based sample of 2 063. Data on sickness absence were retrieved from the Swedish national social insurance registers. Data on health, working and living conditions were gathered through a self-administered questionnaire. The results show that employed women have a notably higher risk for LTSA than employed men. High-strain jobs increase the odds for LTSA among both women and men. Active jobs were also associated with LTSA among women. The study confirms the demand-control model (job strain hypothesis) and social support and their associations with LTSA. However, the job strain hypothesis is more evident in the private sector. Active jobs with high psychological demands and high decision latitude seem to be problematic for many women, especially in the private sector. Thus, the active learning hypothesis receives no support for women in the Swedish working population in general.
The main purpose of this report is to establish a reference point - defined as the data collected up until the end of year 2002 - for the coming phases of the Finnish spent nuclear fuel disposal programme. The focus is: to define the current surface and underground conditions at the site, both as regards the properties for which a change is expected and for the properties which are of particular interest for long-term safety or environmental impact; to establish, as far as possible, the natural fluctuation of properties that are potentially affected by construction of the underground laboratory, the ONKALO, and to provide references to data on parameters or use in model development and testing and to use models to assist in understanding and interpreting the data. The emphasis of the baseline description is on bedrock characteristics that are relevant to the long-term safety of a spent fuel repository and, hence, to include the hydrogeological, hydrogeochemical, rock mechanical, tectonic and seismic conditions of the site. The construction of the ONKALO will also affect some conditions on the surface, and, therefore, a description of the main characteristics of the nature and the man-made constructions at Olkiluoto is also given. This report is primarily a road map to the available information on the prevailing conditions at the Olkiluoto site and a framework for understanding of data collected. Hence, it refers to numerous available background reports and other archived information produced over the past 20 years or more, and forms a recapitulation and revaluation of the characterisation data of the Olkiluoto site. (orig.)
Thayanny Lopes do Vale Barros
Full Text Available Introduction: Congenital heart defects, cardiac malformations that occur in the embryonic period, constitute a serious health problem. They cover a proportion of 8-10 per 1000 live births and contribute to infant mortality. Objective: To identify the socioeconomic status of children undergoing cardiac surgery at the Hospital Universitário da Universidade Federal do Maranhão, in São Luis, the existence of material elements that contribute to worsening conditions. Methods: We conducted a retrospective study with a quantitative approach, descriptive and reflective, from the interviews conducted by the Social Service Social with families of children with heart disease from January 2011 to July 2012. Results: A total of 95 interviews, the results reveal that (75.79% of children have elements that suggest poor socioeconomic conditions. It also shows that only 66.33% lived in brick house, while (31.73% in mud, adobe and straw houses. With regard to income, it showed that only 4.08% received 1-2 minimum wages, while the remaining (95.9% with benchmarks oscillating half the minimum wage (27.55%, 1/4 of the minimum wage and (24.48% and income below 70 dollars per person, featuring extreme poverty. On the social security situation prevailing at children with no ties to 61.22%. With respect to benefits, we found that only (12.24% of children were in the enjoyment of the Continuous Cash Benefit - CCB. Conclusion: Poor socioeconomic conditions listed as major obstacles in meeting the needs, resulting in the maintenance of health conditions and even allowing the aggravation of an existing pathology.
McLeigh, Jill D; Kilmer, Ryan P
This editorial introduces this special section of the American Journal of Orthopsychiatry . The Global Alliance for Behavioral Health and Social Justice (formerly the American Orthopsychiatric Association) has developed the theme for its track at the 2016 Annual Research and Policy Conference on Child, Adolescent, and Young Adult Behavioral Health. The Global Alliance, the parent organization of the American Journal of Orthopsychiatry , has long sought to address prevailing social conditions by treating them as problems to be solved through multilevel, contextually grounded social interventions. Indeed, throughout the organization's history, it has advocated for focusing on the effects of social determinants of health (e.g., racism, violence, poverty, oppression, war) on behavioral health and for doing so across contexts, such as the family, community, and broader social environment. In keeping with the organization's history and the current social context, the theme for the Global Alliance's track was "Changing norms, strategies, and systems to support behavioral health and social justice." This special section includes articles that build on four of the presentations and two award addresses delivered as part of the Global Alliance's track. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
Wahn, Elisabeth Hertfelt; Nissen, Eva
Among Swedish pregnant teenage girls it is unusual to continue pregnancy and to choose to have a baby. Swedish teenage mothers can therefore be expected to differ from adult mothers, at a group level. The aim of this study was to describe and compare teenage mothers who were giving birth in hospital with adult mothers as to sociodemographic background, perception of health and social support. A descriptive comparative study was conducted over one year, in a county in south-western Sweden, which comprised a group of all teenage mothers aged 15-19, who gave birth at hospital (study group n=97) and the same number of adult mothers aged 25-29, matched for parity and birth of a baby closest to the index mother (reference group). Both groups answered a questionnaire regarding sociodemographic variables, lifestyle, health, self-esteem, depressive symptoms, and support. Information on the mothers' pregnancy and delivery was obtained from their maternal health and delivery charts. Teenage mothers had more often been exposed to a difficult family situation, had more often experienced school failure than adult mothers, and showed health-risk behavior. Teenage mothers perceived less support, had lower self-esteem, and more depressive symptoms than adult mothers. Teenage mothers differed from adult mothers regarding family situation and health behavior as well as perception of support, self-esteem, and depressive symptoms, which may negatively influence their ability to cope with parenthood. Efforts should be made early in pregnancy to meet both health and support needs of teenage mothers.
Rose Marie Santini
Full Text Available This article analyzes the social logics underlying audiovisualconsumption on digital networks. We retrieved some data on the Internet globaltraffic of audiovisual files since 2008 to identify formats, modes of distributionand consumption of audiovisual contents that tend to prevail on the Web. Thisresearch shows the types of social practices which are dominant among usersand its relation to what we designate as “Internet culture”.
Manstead, Antony S R
Drawing on recent research on the psychology of social class, I argue that the material conditions in which people grow up and live have a lasting impact on their personal and social identities and that this influences both the way they think and feel about their social environment and key aspects of their social behaviour. Relative to middle-class counterparts, lower/working-class individuals are less likely to define themselves in terms of their socioeconomic status and are more likely to have interdependent self-concepts; they are also more inclined to explain social events in situational terms, as a result of having a lower sense of personal control. Working-class people score higher on measures of empathy and are more likely to help others in distress. The widely held view that working-class individuals are more prejudiced towards immigrants and ethnic minorities is shown to be a function of economic threat, in that highly educated people also express prejudice towards these groups when the latter are described as highly educated and therefore pose an economic threat. The fact that middle-class norms of independence prevail in universities and prestigious workplaces makes working-class people less likely to apply for positions in such institutions, less likely to be selected and less likely to stay if selected. In other words, social class differences in identity, cognition, feelings, and behaviour make it less likely that working-class individuals can benefit from educational and occupational opportunities to improve their material circumstances. This means that redistributive policies are needed to break the cycle of deprivation that limits opportunities and threatens social cohesion. © 2018 The Author. British Journal of Social Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.
Carpenter, Russ E.; Summers, Cliff H.
This paper describes a model of fear learning, in which subjects have an option of behavioral responses to impending social defeat. The model generates two types of learning: social avoidance and classical conditioning, dependent upon 1) escape from or 2) social subordination to an aggressor. We hypothesized that social stress provides the impetus as well as the necessary information to stimulate dichotomous goal-oriented learning. Specialized tanks were constructed to subject rainbow trout t...
The fate of eggs and larvae of three pelagic species, mackerel (Scomber scombrus, horse mackerel (Trachurus trachurus and sardine (Sardina pilchardus in relation to prevailing currents in the Bay of Biscay: Could they affect larval survival?
Full Text Available The spatial distribution of eggs and larvae of three pelagic species, mackerel, horse mackerel and sardine, in the Bay of Biscay was studied in 1998, 2001 and 2004. The spatial distribution was clearly different between the years studied and corresponds quite precisely to different water circulation regimes. Mackerel and horse mackerel larvae are more affected by the prevailing currents than sardine, as their spawning grounds are located offshore, far from the shelf break where the current velocities are higher. Survival rates for mackerel and horse mackerel were higher in 2001, when the offshore larval transport was stronger. However, for sardine, the mortality rate hardly varied between years. The abundance of 25-day-old larvae, considered as an index of the survival rate, appears to be a good recruitment indicator, at least for 1998, 2001 and 2004. Our results did not support the hypothesis of Bakun (1996, which states that dispersion of early life stages towards open ocean waters should cause high larval mortality. At least under the conditions observed for the years studied, the retention of larvae offshore appears to have a positive effect on larval growth and/or survival.
Graff, J N; Baciarello, G; Armstrong, A J; Higano, C S; Iversen, P; Flaig, T W; Forer, D; Parli, T; Phung, D; Tombal, B; Beer, T M; Sternberg, C N
Prostate cancer disproportionately affects older men. Because age affects treatment decisions, it is important to understand the efficacy and tolerability of therapies for advanced prostate cancer in elderly men. This analysis describes efficacy and safety outcomes in men aged ≥75 years who received enzalutamide, an androgen receptor inhibitor, in the phase III PREVAIL trial. PREVAIL was a randomised, double-blind, multinational study of oral enzalutamide 160 mg/day (N = 872) versus placebo (N = 845) in chemotherapy-naive men with metastatic castration-resistant prostate cancer. Overall survival (OS) and radiographic progression-free survival (rPFS) were coprimary end points. Subgroup analysis of men aged ≥75 years (elderly) and men aged PREVAIL, median treatment duration was 16.6 and 5.0 months in the enzalutamide and placebo arms, respectively. In the elderly subgroup, OS was greater with enzalutamide than with placebo [32.4 months (95% confidence interval (CI) 27.7-not yet reached] versus 25.1 months (95% CI 22.6-28.0); hazard ratio (HR) = 0.61 (95% CI 0.47-0.79); P = 0.0001], as was rPFS [not yet reached (95% CI 12.3-not yet reached) versus 3.7 months (95% CI 3.6-5.3); HR = 0.17 (95% CI 0.12-0.24); P < 0.0001]. Irrespective of treatment assignment, incidence of AEs was similar between the two age groups, except for an overall higher incidence of falls among elderly patients than younger patients [84/609 (13.8%) versus 62/1106 (5.6%)] and among elderly patients receiving enzalutamide than those receiving placebo [61/317 (19.2%) versus 23/292 (7.9%)]. Elderly men benefited from treatment with enzalutamide in terms of OS and rPFS. Enzalutamide was well tolerated in the elderly subgroup and those aged <75 years. Age and enzalutamide treatment were associated with a higher incidence of falls. NCT01212991, ClinicalTrials.gov. © The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For
Søndergaard, Dorte Marie
Social exclusion anxiety is a term which builds on a social-psychological concept of human beings as existentially dependent on social embeddedness. This entry explores the concept in relation to bullying among children, which is a widespread and serious problem in schools and institutions. Social...... exclusion anxiety and longing for belonging are both central aspects of the affects and processes that enact and challenge social groups. Social exclusion anxiety should not be confused with ‘social phobia’, which is a concept within clinical psychology that focuses on the individual and refers to a phobic...... psychological condition. Social exclusion anxiety instead points to a distributed affect which circulates and smolders in all social groups. This is the result of an ever-present risk of someone being judged unworthy to belong to, or deemed not a legitimate participant in, a social group. Such anxiety may...
Stoeger, Angela S; Baotic, Anton
Until recently, the prevailing theory about male African elephants (Loxodonta africana) was that, once adult and sexually mature, males are solitary and targeted only at finding estrous females. While this is true during the state of 'musth' (a condition characterized by aggressive behavior and elevated androgen levels), 'non-musth' males exhibit a social system seemingly based on companionship, dominance and established hierarchies. Research on elephant vocal communication has so far focused on females, and very little is known about the acoustic structure and the information content of male vocalizations. Using the source and filter theory approach, we analyzed social rumbles of 10 male African elephants. Our results reveal that male rumbles encode information about individuality and maturity (age and size), with formant frequencies and absolute fundamental frequency values having the most informative power. This first comprehensive study on male elephant vocalizations gives important indications on their potential functional relevance for male-male and male-female communication. Our results suggest that, similar to the highly social females, future research on male elephant vocal behavior will reveal a complex communication system in which social knowledge, companionship, hierarchy, reproductive competition and the need to communicate over long distances play key roles.
Kim, Choung-Soo; Theeuwes, Ad; Kwon, Dong Deuk; Choi, Young Deuk; Chung, Byung Ha; Lee, Hyun Moo; Lee, Kang Hyun; Lee, Sang Eun
This post hoc analysis evaluated treatment effects, safety, and pharmacokinetics of enzalutamide in Korean patients in the phase 3, double-blind, placebo-controlled PREVAIL trial. Asymptomatic or mildly symptomatic chemotherapy-naive men with metastatic castration-resistant prostate cancer that progressed on androgen deprivation therapy received 160 mg/d oral enzalutamide or placebo (1:1) until death or discontinuation due to radiographic progression or skeletal-related event and initiation of subsequent therapy. Coprimary end points were centrally assessed radiographic progression-free survival (rPFS) and overall survival (OS). Secondary end points included investigator-assessed rPFS, time to initiation of chemotherapy, time to prostate-specific antigen (PSA) progression, PSA response (≥50% decline), and time to skeletal-related event. Of 1,717 total patients, 78 patients were enrolled in Korea (enzalutamide, n=40; placebo, n=38). Hazard ratios (95% confidence interval) for enzalutamide versus placebo were 0.23 (0.02-2.24) for centrally assessed rPFS, 0.77 (0.28-2.15) for OS, 0.21 (0.08-0.51) for time to chemotherapy, and 0.31 (0.17-0.56) for time to PSA progression. A PSA response was observed in 70.0% of enzalutamide-treated and 10.5% of placebo-treated Korean patients. Adverse events of grade ≥3 occurred in 33% of enzalutamide-treated and 11% of placebo-treated Korean patients, with median treatment durations of 13.0 and 5.1 months, respectively. At 13 weeks, the plasma concentration of enzalutamide plus N-desmethyl enzalutamide was similar in Korean and non-Korean patients (geometric mean ratio, 1.04; 90% confidence interval, 0.97-1.10). In Korean patients, treatment effects and safety of enzalutamide were consistent with those observed in the overall PREVAIL study population (ClinicalTrials.gov Identifier: NCT01212991).
Pelliccia, Francesco; Trani, Carlo; Biondi-Zoccai, Giuseppe G L; Nazzaro, Marco; Berni, Andrea; Patti, Giuseppe; Patrizi, Roberto; Pironi, Bruno; Mazzarotto, Pietro; Gioffrè, Gaetano; Speciale, Giulio; Pristipino, Christian
It remains undefined if transradial coronary angiography from a right or left radial arterial approach differs in real-world practice. To address this issue, we performed a subanalysis of the PREVAIL study. The PREVAIL study was a prospective, multicenter, observational survey of unselected consecutive patients undergoing invasive cardiovascular procedures over a 1-month observation period, specifically aimed at assessing the outcomes of radial approach in the contemporary real world. The choice of arterial approach was left to the discretion of the operator. Prespecified end points of this subanalysis were procedural characteristics. Of 1,052 patients consecutively enrolled, 509 patients underwent transradial catheterization, 304 with a right radial and 205 with a left radial approach. Procedural success rates were similar between the 2 groups. Compared to the left radial group, the right radial group had longer procedure duration (46 ± 29 vs 33 ± 24 minutes, p <0.0001) and fluoroscopy time (765 ± 787 vs 533 ± 502, p <0.0001). At multivariate analysis, including a parsimonious propensity score for the choice of left radial approach, duration of procedure (beta coefficient 11.38, p <0.001) and total dose-area product (beta coefficient 11.38, p <0.001) were independently associated with the choice of the left radial artery approach. The operator's proficiency in right/left radial approach did not influence study results. In conclusion, right and left radial approaches are feasible and effective to perform percutaneous procedures. In the contemporary real world, however, the left radial route is associated with shorter procedures and lower radiologic exposure than the right radial approach, independently of an operator's proficiency. Copyright © 2012 Elsevier Inc. All rights reserved.
Song, Jiangning; Li, Fuyi; Takemoto, Kazuhiro; Haffari, Gholamreza; Akutsu, Tatsuya; Chou, Kuo-Chen; Webb, Geoffrey I
Determining the catalytic residues in an enzyme is critical to our understanding the relationship between protein sequence, structure, function, and enhancing our ability to design novel enzymes and their inhibitors. Although many enzymes have been sequenced, and their primary and tertiary structures determined, experimental methods for enzyme functional characterization lag behind. Because experimental methods used for identifying catalytic residues are resource- and labor-intensive, computational approaches have considerable value and are highly desirable for their ability to complement experimental studies in identifying catalytic residues and helping to bridge the sequence-structure-function gap. In this study, we describe a new computational method called PREvaIL for predicting enzyme catalytic residues. This method was developed by leveraging a comprehensive set of informative features extracted from multiple levels, including sequence, structure, and residue-contact network, in a random forest machine-learning framework. Extensive benchmarking experiments on eight different datasets based on 10-fold cross-validation and independent tests, as well as side-by-side performance comparisons with seven modern sequence- and structure-based methods, showed that PREvaIL achieved competitive predictive performance, with an area under the receiver operating characteristic curve and area under the precision-recall curve ranging from 0.896 to 0.973 and from 0.294 to 0.523, respectively. We demonstrated that this method was able to capture useful signals arising from different levels, leveraging such differential but useful types of features and allowing us to significantly improve the performance of catalytic residue prediction. We believe that this new method can be utilized as a valuable tool for both understanding the complex sequence-structure-function relationships of proteins and facilitating the characterization of novel enzymes lacking functional annotations
Pineo, Graham; Lin, Jay; Stern, Lee; Subrahmanian, Tarun; Annemans, Lieven
The PREVAIL (Prevention of VTE [venous thromboembolism] after acute ischemic stroke with LMWH [low-molecular-weight heparin] and UFH [unfractionated heparin]) study demonstrated a 43% VTE risk reduction with enoxaparin versus UFH in patients with acute ischemic stroke (AIS). A 1% rate of symptomatic intracranial and major extracranial hemorrhage was observed in both groups. To determine the economic impact, from a hospital perspective, of enoxaparin versus UFH for VTE prophylaxis after AIS. A decision-analytic model was constructed and hospital-based costs analyzed using clinical information from PREVAIL. Total hospital costs were calculated based on mean costs in the Premier™ database and from wholesalers acquisition data. Costs were also compared in patients with severe stroke (National Institutes of Health Stroke Scale [NIHSS] score ≥14) and less severe stroke (NIHSS score <14). The average cost per patient due to VTE or bleeding events was lower with enoxaparin versus UFH ($422 vs $662, respectively; net savings $240). The average anticoagulant cost, including drug-administration cost per patient, was lower with UFH versus enoxaparin ($259 vs $360, respectively; net savings $101). However, when both clinical events and drug-acquisition costs were considered, the total hospital cost was lower with enoxaparin versus UFH ($782 vs $922, respectively; savings $140). Hospital cost-savings were greatest ($287) in patients with NIHSS scores ≥14. The higher drug cost of enoxaparin was offset by the reduction in clinical events as compared to the use of UFH for VTE prophylaxis after an AIS, particularly in patients with severe stroke. Copyright © 2011 Society of Hospital Medicine.
Sawa, Yoshiki; Takayama, Morimasa; Goto, Tsuyoshi; Takanashi, Shuichiro; Komiya, Tatsuhiko; Tobaru, Tetsuya; Maeda, Koichi; Kuratani, Toru; Sakata, Yasushi
Transcatheter aortic valve replacement (TAVR) has been an alternative less invasive therapy for high-surgical risk/inoperable patients with aortic valve stenosis (AS) in Japan. We report 5-year outcomes of the first pivotal clinical trial of TAVR in Japan (PREVAIL JAPAN).Methods and Results:A total of 64 patients with AS who were considered unsuitable candidates for surgery were enrolled at 3 centers in Japan (mean age: 84.3±6.1 years, female: 65.6%, STS score: 9.0±4.5%). Transfemoral approach (TF) and transapical approach (TA) was performed in 37 patients and 27 patients, respectively. At 5 years, freedom from all-cause death was 52.7% (TF: 51.3%, TA: 56.3%). Risk of all stroke at 5-year was 15.8% (TF: 8.9%, TA: 25.5%) and risk of major adverse cardiac and cerebrovascular events at 5 years was 58.0% (TF: 51.3%, TA: 69.2%). Mild or greater aortic regurgitation (AR) at 1 week was not associated with increased all-cause death at 5 years (69.1%) compared with none or trace AR (48.3%) (P=0.184). Patients with high STS score (>8) had higher mortality rate than those with low STS scores (≤8). The 5-year data from PREVAIL JAPAN show the clinical benefit of TAVR and suggest that balloon-expandable TAVR is an effective treatment option for Japanese patients with severe AS who are not suitable for surgery. (Funded by Edwards Lifesciences Limited; ClinicalTrials.gov number, NCT01113983.).
Degenhardt, Werner; Wiele, Johannes
Looking at social commerce, a bunch of bewildering phenomena attracts the attention of social psychologists. The way customers participate today shows attitudes and ethical behavior which cannot be explained from the inherent conditions of Web 2.0 environments alone. Fraud often succeeds, when you do not expect it, and honesty can be found under circumstances that do not support honesty at all. The current situation seems to result from customers assigning experience and ethics from real world business to virtual business environments. But there are indications that this situation may change. Social commerce could suffer as soon as customers would use its inherent weaknesses to their own advantage. The following article outlines first approaches to research into this topic.
Full Text Available Entrepreneurship has been the engine propelling much of the growth of the business sector as well as a driving force behind the rapid expansion of the social sector. This article offers a comparative analysis of commercial and social entrepreneurship using a prevailing analytical model from commercial entrepreneurship. The analysis highlights key similarities and differences between these two forms of entrepreneurship and presents a framework on how to approach the social entrepreneurial process more systematically and effectively. We explore the implications of this analysis of social entrepreneurship for both practitioners and researchers.
Matzat, U.; Vrieling, E.M.
Research on the educational consequences of social media has led to divergent findings that are difficult to integrate and studies often examine specific courses. It remains unclear what types of social media use in classroom prevail on a broader scale and how teachers, if at all, can affect
Breathing air in air: in what ways might extant amphibious fish biology relate to prevailing concepts about early tetrapods, the evolution of vertebrate air breathing, and the vertebrate land transition?
Graham, Jeffrey B; Lee, Heather J
The air-breathing fishes have heuristic importance as possible models for the Paleozoic evolution of vertebrate air breathing and the transition to land. A recent hypothesis about this transition suggests that the diverse assemblage of marine amphibious fishes occurring primarily in tropical, high intertidal zone habitats are analogs of early tetrapods and that the intertidal zone, not tropical freshwater lowlands, was the springboard habitat for the Devonian land transition by vertebrates. Here we argue that selection pressures imposed by life in the intertidal zone are insufficient to have resulted in the requisite aerial respiratory capacity or the degree of separation from water required for the vertebrate land transition. The extant marine amphibious fishes, which occur mainly on rocky shores or mudflats, have reached the limit of their niche expansion onto land and remain tied to water by respiratory structures that are less efficient in air and more vulnerable to desiccation than lungs. We further argue that evolutionary contingencies actuated by the Devonian origin of the tetrapods marked a critical point of divergence for a way of life in which selection pressures would operate on the physiology, morphology, and natural history of the different vertebrate groups. While chronically hypoxic and shallow water conditions in the habitats of some primitive bony fishes and some amphibians appear similar to the conditions that prevailed in the Devonian, markedly different selection pressures have operated on other amphibians and bony fishes over the 300 million years since the vertebrate land transition. For example, both egg development and larval metamorphosis in extant amphibians are geared mainly toward compensating for the uncertainty of habitat water quality or even the absence of water by minimizing the time required to develop there. In contrast, reproduction by most intertidal (and amphibious) fishes, all of which are teleosts, remains dependent on a
Three lifestyle-related issues of major significance for public health among the Inuit in contemporary Greenland: a review of adverse childhood conditions, obesity, and smoking in a period of social transition.
Bjerregaard, Peter; Larsen, Christina V L
Greenland is a country in transition from a colonial past with subsistence hunting and fishing to an urban Nordic welfare state. Epidemiological transition from infectious to chronic diseases has been evident since the 1950s. Ninety percent of the population is Inuit. We studied three public health issues based on published literature, namely adverse childhood experiences, addictive behavior, and suicide; diet and obesity; and smoking. Alcohol consumption was high in the 1970s and 1980s with accompanying family and social disruption. This is still a cause of poor mental health and suicides in the generations most affected. The diet is changing from a traditional diet of fish and marine mammals to imported food including food items rich in sugar and fat from domestic animals, and the level of physical activity is decreasing with an ensuing epidemic rise in obesity. The prevalence of smoking is high at around 60% among both men and women and is only slowly decreasing. Smoking shows large social variation, and tobacco-related diseases are widespread. The diseases and conditions outlined above all contribute towards a low life expectancy at birth-69 years for men and 74 years for women in 2011-2015-compared with 78 and 84 years for men and women, respectively, on average in the European countries. The translation of government public health programs into local activities needs strengthening, and it must be realized that the improvement of public health is a long-term process.
Vasily Astrov; Vladimir Gligorov; Peter Havlik; Mario Holzner; Gabor Hunya; Kazimierz Laski; Sebastian Leitner; Zdenek Lukas; Anton Mihailov; Olga Pindyuk; Leon Podkaminer; Josef Pöschl; Sandor Richter; Waltraut Urban; Hermine Vidovic
The Central, East and Southeast European (CESEE) economies will experience on average a minor rebound of economic growth to 1% in 2010 which will speed up to 2.5% in 2011 and 3.5% in 2012. GDP growth will be higher in the CIS countries and in Turkey, about average in the Central European NMS and lower in the SEE countries and the Baltics. Growth is currently driven mostly by exports which should outweigh the dampening effects of the austerity measures. Whether the countries will actually bene...
Randolph, Gwendalyn J
Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes.
Psychiatry and society are interrelated and the biopsychosocial model continues to dominate the clinical psychiatric practice. Some doubts have been expressed in recent years about the value and the wide acceptance of the biopsychosocial model. Ghaemi (2009)1 considers it to be anti-humanistic and advocates the use of less eclectic, less generic, and less vague alternatives. The fundamental changes that have been witnessed in our times across the spectrum of biology, psychology and sociology have made necessary that a conceptual clarity should prevail. The remarkable advances in neurosciences, neurobiology and genetics tend to swing the emphasis towards a more biological basis. Psychosis for example is the condition often regarded as being biologically constructed and most independent of the social context. The symptoms, however, of hallucinations and delusions in psychosis have social meaning for the person experiencing them and are primarily defined socially.2 Furthermore, vulnerability is often the result of social trauma, whether in the form of recent stressors that trigger onset, or earlier circumstances that shape cognitive and emotional style. Moreover, the approved treatment and management of long term psychiatric disorders has involved interventions that are either directly social, or psychosocial. Furthermore, doubts have also been raised by the endophenotype project,3 related to the genetics of schizophrenia. Cohen4 suggested that there may be more individual genotypic patterns associated with schizophrenia than people with schizophrenia on the planet. A recent alternative interpretation (network approach) is gaining some support. It suggests that a stressor causes symptoms that activate other symptoms, in a circular, self-reinforcing way.5 This theory moves away from psychiatric disorders being traditionally conceptualised as categorical or dimensional models. While psychiatry has shifted its focus to a more biological approach, social factors still
Full Text Available The reform processes and the developments of social policy to solve the major social problems of the socially vulnerable population, among them, children in particular, take place in Latvia during the last 20 years. Protection of children rights is declared one of the strategic priorities of the state social policy. At the same time the problem of child neglect and child abandonment in Latvia has not yet been sufficiently conceptualized. Already since 1990-ies Latvian society has clearly faced with an objective necessity of solving problems of child abandonment in connection with an increasing number of social orphans. The situation was complicated by the fact that the formation of a fundamentally new system of social policy, social support and assistance to risk children had to be developed and implemented in conditions of economic transition to market economy relations, increasing social tensions, and sharp increase in social inequality and social discrimination. Among the enourmous number of economical and social problems in the developing democratic state, the issue of child abandonment as an important social problem has been addressed rather fragmentary. The term “social orphanhood” does not appear in the social policy vocabulary of the Latvian social policy doscourse.
Rathkopf, Dana E; Beer, Tomasz M; Loriot, Yohann; Higano, Celestia S; Armstrong, Andrew J; Sternberg, Cora N; de Bono, Johann S; Tombal, Bertrand; Parli, Teresa; Bhattacharya, Suman; Phung, De; Krivoshik, Andrew; Scher, Howard I; Morris, Michael J
Drug development for metastatic castration-resistant prostate cancer has been limited by a lack of clinically relevant trial end points short of overall survival (OS). Radiographic progression-free survival (rPFS) as defined by the Prostate Cancer Clinical Trials Working Group 2 (PCWG2) is a candidate end point that represents a clinically meaningful benefit to patients. To demonstrate the robustness of the PCWG2 definition and to examine the relationship between rPFS and OS. PREVAIL was a phase 3, randomized, double-blind, placebo-controlled multinational study that enrolled 1717 chemotherapy-naive men with metastatic castration-resistant prostate cancer from September 2010 through September 2012. The data were analyzed in November 2016. Patients were randomized 1:1 to enzalutamide 160 mg or placebo until confirmed radiographic disease progression or a skeletal-related event and initiation of either cytotoxic chemotherapy or an investigational agent for prostate cancer treatment. Sensitivity analyses (SAs) of investigator-assessed rPFS were performed using the final rPFS data cutoff (May 6, 2012; 439 events; SA1) and the interim OS data cutoff (September 16, 2013; 540 events; SA2). Additional SAs using investigator-assessed rPFS from the final rPFS data cutoff assessed the impact of skeletal-related events (SA3), clinical progression (SA4), a confirmatory scan for soft-tissue disease progression (SA5), and all deaths regardless of time after study drug discontinuation (SA6). Correlations between investigator-assessed rPFS (SA2) and OS were calculated using Spearman ρ and Kendall τ via Clayton copula. In the 1717 men (mean age, 72.0 [range, 43.0-93.0] years in enzalutamide arm and 71.0 [range, 42.0-93.0] years in placebo arm), enzalutamide significantly reduced risk of radiographic progression or death in all SAs, with hazard ratios of 0.22 (SA1; 95% CI, 0.18-0.27), 0.31 (SA2; 95% CI, 0.27-0.35), 0.21 (SA3; 95% CI, 0.18-0.26), 0.21 (SA4; 95% CI, 0.17-0.26), 0