WorldWideScience

Sample records for preliminary sensitivity analysis

  1. A Sensitivity Study for an Evaluation of Input Parameters Effect on a Preliminary Probabilistic Tsunami Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rhee, Hyun-Me; Kim, Min Kyu; Choi, In-Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Sheen, Dong-Hoon [Chonnam National University, Gwangju (Korea, Republic of)

    2014-10-15

    The tsunami hazard analysis has been based on the seismic hazard analysis. The seismic hazard analysis has been performed by using the deterministic method and the probabilistic method. To consider the uncertainties in hazard analysis, the probabilistic method has been regarded as attractive approach. The various parameters and their weight are considered by using the logic tree approach in the probabilistic method. The uncertainties of parameters should be suggested by analyzing the sensitivity because the various parameters are used in the hazard analysis. To apply the probabilistic tsunami hazard analysis, the preliminary study for the Ulchin NPP site had been performed. The information on the fault sources which was published by the Atomic Energy Society of Japan (AESJ) had been used in the preliminary study. The tsunami propagation was simulated by using the TSUNAMI{sub 1}.0 which was developed by Japan Nuclear Energy Safety Organization (JNES). The wave parameters have been estimated from the result of tsunami simulation. In this study, the sensitivity analysis for the fault sources which were selected in the previous studies has been performed. To analyze the effect of the parameters, the sensitivity analysis for the E3 fault source which was published by AESJ was performed. The effect of the recurrence interval, the potential maximum magnitude, and the beta were suggested by the sensitivity analysis results. Level of annual exceedance probability has been affected by the recurrence interval.. Wave heights have been influenced by the potential maximum magnitude and the beta. In the future, the sensitivity analysis for the all fault sources in the western part of Japan which were published AESJ would be performed.

  2. Sensitivity analysis

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/003741.htm Sensitivity analysis To use the sharing features on this page, please enable JavaScript. Sensitivity analysis determines the effectiveness of antibiotics against microorganisms (germs) ...

  3. A Sensitivity Analysis of a Pipe Break Accident in a Preliminary Specific Design of the PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwi Lim; Jeong, Jae Ho; Ha, Kwi Seok [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    The PGSFR (Prototype Gen-IV Sodium-cooled Fast Reactor) is a pool type sodium cooled fast reactor with a thermal power of 392.1 MW which has been developed in accord with an enhanced safety, an efficient utilization of uranium resources and a reduction of a high level waste volume in the Korea Atomic Energy Research Institute (KAERI) since 2012 under a National Nuclear R and D Program. The PGSFR has an inherent safety characteristic owing to the design to have a negative power reactivity coefficient during all operation modes and it has a passive safety characteristic due to the design of a passive decay heat removal circuit. In order to assess the inherent safety features of the PGSFR, a safety analysis was performed for a pipe break accident with MARS-LMR. And, the sensitivity studies were also performed to find the most conservative condition. As a result, the PGSFR was appropriately tripped by a high power to PHTS flow ratio using the method of extracting the PHTS flow rate from the pressure drop. The air flow rate was the most sensitive variable in the sensitivity analysis. Therefore, it is important to know the accurate uncertainty of the air flow rate in the AHX.

  4. Preliminary analysis of grain-size populations with environmentally sensitive terrigenous components in marginal sea setting

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Terrigenous components were separated from the bulk sediment of Core A7 from the Okinawa Trough and Core A37 from the Ryukru Trench and grain-size distributions of these sub-samples were analyzed. Based upon an analysis of the grain-size data of the two sedimentary sequences, grain-size populations are identified to be sensitive to sedimentary environmental changes. The modal values and size ranges of the two main grain-size populations in Core A7 are evidently different from those of Core A37, indicating the spatial variability of sediment sources and transport processes between the two places. The downcore variations in the content of the environmentally sensitive grain-size populations reveal that during the accumulation of sedimentary material the environment remained relatively stable at the site where Core A7 was collected, except for the apparent events for the formation of two turbidite layers and a volcanic ash layer. However, the sedimentary sequence of Core A37 shows six sedimentary cycles, indicating a highly variable sedimentary environment at this location.

  5. Quantitative wound healing studies using a portable, low cost, handheld near-infrared optical scanner: preliminary sensitivity and specificity analysis

    Science.gov (United States)

    Lei, Jiali; Rodriguez, Suset; Jayachandran, Maanasa; Solis, Elizabeth; Gonzalez, Stephanie; Perez-Clavijo, Francesco; Wigley, Stephen; Godavarty, Anuradha

    2016-03-01

    Lower extremity ulcers are devastating complications that are still un-recognized. To date, clinicians employ visual inspection of the wound site during its standard 4-week of healing process via monitoring of surface granulation. A novel ultra-portable near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory that can perform non-contact 2D area imaging of the wound site. From preliminary studies it was observed that the nonhealing wounds had a greater absorption contrast with respect to the normal site, unlike in the healing wounds. Currently, non-contact near-infrared (NIR) imaging studies were carried out on 22 lower extremity wounds at two podiatric clinics, and the sensitivity and specificity of the scanner evaluated. A quantitative optical biometric was developed that differentiates healing from non-healing wounds, based on the threshold values obtained during ROC analysis. In addition, optical images of the wound obtained from weekly imaging studies are also assessed to determine the ability of the device to predict wound healing consistently on a periodic basis. This can potentially impact early intervention in the treatment of lower extremity ulcers when an objective and quantitative wound healing approach is developed. Lastly, the incorporation of MATLAB graphical user interface (GUI) to automate the process of image acquisition, image processing and image analysis realizes the potential of NIROS to perform non-contact and real-time imaging on lower extremity wounds.

  6. Research of Current Issues and Preliminary Sensitivity Analysis of Level 3 PSA

    Energy Technology Data Exchange (ETDEWEB)

    Shin, So Eun; Lee, Yong Suk [FNC Technology Co. Ltd., Yongin (Korea, Republic of); Lee, Seung Woo [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-10-15

    Thus, in this study, key current issues came from research on previous studies related to L3 PSA. L3 PSA has been carried out by using MACCS code in Korea on a trial basis. The technique of assessing an off-site radiation effect quantitatively is required because the interest in off-site consequence analysis has been increased after the Fukushima accident. Therefore, in order to use Level 3 PSA(L3 PSA) in Korea, methods of calculating MACCS(MELCOR Accident Consequence Code System) code to be adequate for domestic circumstances in Korea were investigated. If L3 PSA is performed in Korea, it will be possible to raise many issues. Since MACCS code is based on the U.S., input parameters and the scope of analysis were set by considering circumstances of the U.S. For this reason, by focusing on solutions to current issues, the method for reflecting circumstances of Korea in L3 PSA was investigated. It is also required to find out methods for decreasing uncertainty of L3 PSA in Korea.

  7. Purification, crystallization and preliminary crystallographic analysis of Est25: a ketoprofen-specific hormone-sensitive lipase

    Energy Technology Data Exchange (ETDEWEB)

    Kim, SeungBum [Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon (Korea, Republic of); Joo, Sangbum [Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Yoon, Hyun C.; Ryu, Yeonwoo [Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon (Korea, Republic of); Kim, Kyeong Kyu, E-mail: kkim@med.skku.ac.kr [Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon (Korea, Republic of); Kim, T. Doohun, E-mail: kkim@med.skku.ac.kr [Department of Biological and Molecular Engineering, College of Engineering, Ajou University, Suwon (Korea, Republic of)

    2007-07-01

    Est25, a ketoprofen-specific hormone-sensitive lipase from a metagenomic library, was crystallized and diffraction data were collected to 1.49 Å resolution. Ketoprofen, a nonsteroidal anti-inflammatory drug, inhibits the synthesis of prostaglandin. A novel hydrolase (Est25) with high ketoprofen specificity has previously been identified using a metagenomic library from environmental samples. Recombinant Est25 protein with a histidine tag at the N-terminus was expressed in Escherichia coli and purified in a homogenous form. Est25 was crystallized from 2.4 M sodium malonate pH 7.0 and X-ray diffraction data were collected to 1.49 Å using synchrotron radiation. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 197.8, b = 95.2, c = 99.4 Å, β = 97.1°.

  8. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part of the w......The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...

  9. UVISS preliminary visibility analysis

    DEFF Research Database (Denmark)

    Betto, Maurizio

    1998-01-01

    The goal of this work is to obtain a preliminary assessment of the sky visibility for anastronomical telescope located on the express pallet of the International SpaceStation (ISS)} taking into account the major constraints imposed on the instrument by the ISSattitude and structure. Part...

  10. Sensitivity and uncertainty analysis

    CERN Document Server

    Cacuci, Dan G; Navon, Ionel Michael

    2005-01-01

    As computer-assisted modeling and analysis of physical processes have continued to grow and diversify, sensitivity and uncertainty analyses have become indispensable scientific tools. Sensitivity and Uncertainty Analysis. Volume I: Theory focused on the mathematical underpinnings of two important methods for such analyses: the Adjoint Sensitivity Analysis Procedure and the Global Adjoint Sensitivity Analysis Procedure. This volume concentrates on the practical aspects of performing these analyses for large-scale systems. The applications addressed include two-phase flow problems, a radiative c

  11. Integrated Sensitivity Analysis Workflow

    Energy Technology Data Exchange (ETDEWEB)

    Friedman-Hill, Ernest J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoffman, Edward L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gibson, Marcus J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Clay, Robert L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-08-01

    Sensitivity analysis is a crucial element of rigorous engineering analysis, but performing such an analysis on a complex model is difficult and time consuming. The mission of the DART Workbench team at Sandia National Laboratories is to lower the barriers to adoption of advanced analysis tools through software integration. The integrated environment guides the engineer in the use of these integrated tools and greatly reduces the cycle time for engineering analysis.

  12. Concept Overview & Preliminary Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Mark

    2017-07-12

    'H2@Scale' is an opportunity for wide-scale use of hydrogen as an intermediate that carries energy from various production options to multiple uses. It is based on identifying and developing opportunities for low-cost hydrogen production and investigating opportunities for using that hydrogen across the electricity, industrial, and transportation sectors. One of the key production opportunities is use of low-cost electricity that may be generated under high penetrations of variable renewable generators such as wind and solar photovoltaics. The technical potential demand for hydrogen across the sectors is 60 million metric tons per year. The U.S. has sufficient domestic renewable resources so that each could meet that demand and could readily meet the demand using a portfolio of generation options. This presentation provides an overview of the concept and the technical potential demand and resources. It also motivates analysis and research on H2@Scale.

  13. Sensitivity analysis of SPURR

    Energy Technology Data Exchange (ETDEWEB)

    Witholder, R.E.

    1980-04-01

    The Solar Energy Research Institute has conducted a limited sensitivity analysis on a System for Projecting the Utilization of Renewable Resources (SPURR). The study utilized the Domestic Policy Review scenario for SPURR agricultural and industrial process heat and utility market sectors. This sensitivity analysis determines whether variations in solar system capital cost, operation and maintenance cost, and fuel cost (biomass only) correlate with intuitive expectations. The results of this effort contribute to a much larger issue: validation of SPURR. Such a study has practical applications for engineering improvements in solar technologies and is useful as a planning tool in the R and D allocation process.

  14. Preliminary hazards analysis -- vitrification process

    Energy Technology Data Exchange (ETDEWEB)

    Coordes, D.; Ruggieri, M.; Russell, J.; TenBrook, W.; Yimbo, P. [Science Applications International Corp., Pleasanton, CA (United States)

    1994-06-01

    This paper presents a Preliminary Hazards Analysis (PHA) for mixed waste vitrification by joule heating. The purpose of performing a PHA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PHA is then followed by a Preliminary Safety Analysis Report (PSAR) performed during Title 1 and 2 design. The PSAR then leads to performance of the Final Safety Analysis Report performed during the facility`s construction and testing. It should be completed before routine operation of the facility commences. This PHA addresses the first four chapters of the safety analysis process, in accordance with the requirements of DOE Safety Guidelines in SG 830.110. The hazards associated with vitrification processes are evaluated using standard safety analysis methods which include: identification of credible potential hazardous energy sources; identification of preventative features of the facility or system; identification of mitigative features; and analyses of credible hazards. Maximal facility inventories of radioactive and hazardous materials are postulated to evaluate worst case accident consequences. These inventories were based on DOE-STD-1027-92 guidance and the surrogate waste streams defined by Mayberry, et al. Radiological assessments indicate that a facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous materials assessment indicates that a Mixed Waste Vitrification facility will be a Low Hazard facility having minimal impacts to offsite personnel and the environment.

  15. Sensitivity to Pain Traumatization Scale: development, validation, and preliminary findings

    Science.gov (United States)

    Katz, Joel; Fashler, Samantha R; Wicks, Claire; Pagé, M Gabrielle; Roosen, Kaley M; Kleiman, Valery; Clarke, Hance

    2017-01-01

    Background This article reports three studies describing the development and validation of the 12-item Sensitivity to Pain Traumatization Scale (SPTS-12). SPT refers to the anxiety-related cognitive, emotional, and behavioral reactions to pain that resemble the features of a traumatic stress reaction. Methods In Study 1, a preliminary set of 79 items was administered to 116 participants. The data were analyzed by using combined nonparametric and parametric item response theory resulting in a 12-item scale with a one-factor structure and good preliminary psychometric properties. Studies 2 and 3 assessed the factor structure and psychometric properties of the SPTS-12 in a community sample of 823 participants (268 with chronic pain and 555 pain-free) and a clinical sample of 345 patients (126 with chronic post-surgical pain, 92 with other nonsurgical chronic pain, and 127 with no chronic pain) at least 6 months after undergoing coronary artery bypass graft surgery, respectively. Results The final SPTS-12 derived from Study 1 comprised 12 items that discriminated between individuals with different levels of SPT, with the overall scale showing good to very good reliability and validity. The results from Studies 2 and 3 revealed a one-factor structure for chronic pain and pain-free samples, excellent reliability and concurrent validity, and moderate convergent and discriminant validity. Conclusion The results of the three studies provide preliminary evidence for the validity and reliability of the SPTS-12. PMID:28615962

  16. Hydrothermal Liquefaction Treatment Preliminary Hazard Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, Peter P.; Wagner, Katie A.

    2015-08-31

    A preliminary hazard assessment was completed during February 2015 to evaluate the conceptual design of the modular hydrothermal liquefaction treatment system. The hazard assessment was performed in 2 stages. An initial assessment utilizing Hazard Identification and Preliminary Hazards Analysis (PHA) techniques identified areas with significant or unique hazards (process safety-related hazards) that fall outside of the normal operating envelope of PNNL and warranted additional analysis. The subsequent assessment was based on a qualitative What-If analysis. This analysis was augmented, as necessary, by additional quantitative analysis for scenarios involving a release of hazardous material or energy with the potential for affecting the public.

  17. Vibration Sensitive Keystroke Analysis

    NARCIS (Netherlands)

    Lopatka, M.; Peetz, M.-H.; van Erp, M.; Stehouwer, H.; van Zaanen, M.

    2009-01-01

    We present a novel method for performing non-invasive biometric analysis on habitual keystroke patterns using a vibration-based feature space. With the increasing availability of 3-D accelerometer chips in laptop computers, conventional methods using time vectors may be augmented using a distinct fe

  18. Preliminary safety analysis methodology for the SMART

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Kyoo Hwan; Chung, Y. J.; Kim, H. C.; Sim, S. K.; Lee, W. J.; Chung, B. D.; Song, J. H. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-03-01

    This technical report was prepared for a preliminary safety analysis methodology of the 330MWt SMART (System-integrated Modular Advanced ReacTor) which has been developed by Korea Atomic Energy Research Institute (KAERI) and funded by the Ministry of Science and Technology (MOST) since July 1996. This preliminary safety analysis methodology has been used to identify an envelope for the safety of the SMART conceptual design. As the SMART design evolves, further validated final safety analysis methodology will be developed. Current licensing safety analysis methodology of the Westinghouse and KSNPP PWRs operating and under development in Korea as well as the Russian licensing safety analysis methodology for the integral reactors have been reviewed and compared to develop the preliminary SMART safety analysis methodology. SMART design characteristics and safety systems have been reviewed against licensing practices of the PWRs operating or KNGR (Korean Next Generation Reactor) under construction in Korea. Detailed safety analysis methodology has been developed for the potential SMART limiting events of main steam line break, main feedwater pipe break, loss of reactor coolant flow, CEA withdrawal, primary to secondary pipe break and the small break loss of coolant accident. SMART preliminary safety analysis methodology will be further developed and validated in parallel with the safety analysis codes as the SMART design further evolves. Validated safety analysis methodology will be submitted to MOST as a Topical Report for a review of the SMART licensing safety analysis methodology. Thus, it is recommended for the nuclear regulatory authority to establish regulatory guides and criteria for the integral reactor. 22 refs., 18 figs., 16 tabs. (Author)

  19. 75 FR 8925 - Pressure Sensitive Plastic Tape from Italy: Preliminary Results of Antidumping Duty Changed...

    Science.gov (United States)

    2010-02-26

    ... International Trade Administration Pressure Sensitive Plastic Tape from Italy: Preliminary Results of... pressure sensitive plastic tape from Italy pursuant to section 751(b) of the Tariff Act of 1930, as amended... review request. See Pressure Sensitive Plastic Tape from Italy: Notice of Initiation of Antidumping...

  20. Preliminary Analysis of Google+'s Privacy

    OpenAIRE

    2011-01-01

    In this paper we provide a preliminary analysis of Google+ privacy. We identified that Google+ shares photo metadata with users who can access the photograph and discuss its potential impact on privacy. We also identified that Google+ encourages the provision of other names including maiden name, which may help criminals performing identity theft. We show that Facebook lists are a superset of Google+ circles, both functionally and logically, even though Google+ provides a better user interfac...

  1. Phantom pain : A sensitivity analysis

    NARCIS (Netherlands)

    Borsje, Susanne; Bosmans, JC; Van der Schans, CP; Geertzen, JHB; Dijkstra, PU

    2004-01-01

    Purpose : To analyse how decisions to dichotomise the frequency and impediment of phantom pain into absent and present influence the outcome of studies by performing a sensitivity analysis on an existing database. Method : Five hundred and thirty-six subjects were recruited from the database of an o

  2. An analysis of sensitivity tests

    Energy Technology Data Exchange (ETDEWEB)

    Neyer, B.T.

    1992-03-06

    A new method of analyzing sensitivity tests is proposed. It uses the Likelihood Ratio Test to compute regions of arbitrary confidence. It can calculate confidence regions for the parameters of the distribution (e.g., the mean, {mu}, and the standard deviation, {sigma}) as well as various percentiles. Unlike presently used methods, such as those based on asymptotic analysis, it can analyze the results of all sensitivity tests, and it does not significantly underestimate the size of the confidence regions. The main disadvantage of this method is that it requires much more computation to calculate the confidence regions. However, these calculations can be easily and quickly performed on most computers.

  3. Preliminary Studies on X-Ray-sensitive Liposome

    Institute of Scientific and Technical Information of China (English)

    MENG Fan-xu; XU Hua-ping; QI Yan-fei; XU Kun; SONG Xiu-ling; NIU Shu; LI Juan

    2012-01-01

    The synthesis of a new type of X-ray-sensitive compound “di-(1-hydroxylundecyl)diselenide” and its application in the preparation of a new type of liposome with X-ray sensitivity was reported.This new liposome was synthesized to encapsulate doxorubicin hydrochloride(Dox),with its physical and chemical properties,stability,and radiation sensitivity determined.Based on the pH-gradient method,liposomal Dox was prepared via ultrasonic emulsification and then purified on a Sephadex G50 mini-column.UV spectrophotometry and liquid chromatography were used to detect the encapsulation efficiency and radiation sensitivity of the Dox-loaded liposome.The results show that through changes in release rate,this liposome shows a relative radiosensitivity.In terms of radiation sensitivity,the drug leak rate of the X-ray-sensitive Dox-loaded liposome increased gradually and peaked at 65.4% under the X-ray radiation of a dose of 10 Gy or more than 10 Gy,which is significantly different from that of ordinary liposomes.Meanwhile,X-ray-sensitive Dox-loaded liposome has a good dispersion stability,with an average particle size of approximate 120 nm.The efficiency of this liposome encapsulating Dox was 75.84%,slightly lower than that of ordinary liposomes.The X-ray-sensitive Dox-loaded liposome exhibited suspension stability within 30 d of storage at 4 ℃,without visible precipitation.Di-(1-hydroxylundecyl)diselenide is safe and noncytotoxic and compared with those of synthetic phospholipids its synthesis is low cost and does not require complex conditions.

  4. Sensitivity analysis in remote sensing

    CERN Document Server

    Ustinov, Eugene A

    2015-01-01

    This book contains a detailed presentation of general principles of sensitivity analysis as well as their applications to sample cases of remote sensing experiments. An emphasis is made on applications of adjoint problems, because they are more efficient in many practical cases, although their formulation may seem counterintuitive to a beginner. Special attention is paid to forward problems based on higher-order partial differential equations, where a novel matrix operator approach to formulation of corresponding adjoint problems is presented. Sensitivity analysis (SA) serves for quantitative models of physical objects the same purpose, as differential calculus does for functions. SA provides derivatives of model output parameters (observables) with respect to input parameters. In remote sensing SA provides computer-efficient means to compute the jacobians, matrices of partial derivatives of observables with respect to the geophysical parameters of interest. The jacobians are used to solve corresponding inver...

  5. Reinforcement Sensitivity and Responsiveness to Performance Feedback: A Preliminary Investigation

    Science.gov (United States)

    Lovett, Benjamin J.; Eckert, Tanya L.

    2009-01-01

    Variability in responsiveness to academic interventions is a common phenomenon in school psychology practice, but the variables associated with this responsiveness are not well understood. Reinforcement sensitivity, a generalized tendency to learn quickly in reward contingency situations, is one variable for increased understanding. In the present…

  6. Reinforcement Sensitivity and Responsiveness to Performance Feedback: A Preliminary Investigation

    Science.gov (United States)

    Lovett, Benjamin J.; Eckert, Tanya L.

    2009-01-01

    Variability in responsiveness to academic interventions is a common phenomenon in school psychology practice, but the variables associated with this responsiveness are not well understood. Reinforcement sensitivity, a generalized tendency to learn quickly in reward contingency situations, is one variable for increased understanding. In the present…

  7. Preliminary Hazards Analysis Plasma Hearth Process

    Energy Technology Data Exchange (ETDEWEB)

    Aycock, M.; Coordes, D.; Russell, J.; TenBrook, W.; Yimbo, P. [Science Applications International Corp., Pleasanton, CA (United States)

    1993-11-01

    This Preliminary Hazards Analysis (PHA) for the Plasma Hearth Process (PHP) follows the requirements of United States Department of Energy (DOE) Order 5480.23 (DOE, 1992a), DOE Order 5480.21 (DOE, 1991d), DOE Order 5480.22 (DOE, 1992c), DOE Order 5481.1B (DOE, 1986), and the guidance provided in DOE Standards DOE-STD-1027-92 (DOE, 1992b). Consideration is given to ft proposed regulations published as 10 CFR 830 (DOE, 1993) and DOE Safety Guide SG 830.110 (DOE, 1992b). The purpose of performing a PRA is to establish an initial hazard categorization for a DOE nuclear facility and to identify those processes and structures which may have an impact on or be important to safety. The PHA is typically performed during and provides input to project conceptual design. The PRA then is followed by a Preliminary Safety Analysis Report (PSAR) performed during Title I and II design. This PSAR then leads to performance of the Final Safety Analysis Report performed during construction, testing, and acceptance and completed before routine operation. Radiological assessments indicate that a PHP facility, depending on the radioactive material inventory, may be an exempt, Category 3, or Category 2 facility. The calculated impacts would result in no significant impact to offsite personnel or the environment. Hazardous material assessments indicate that a PHP facility will be a Low Hazard facility having no significant impacts either onsite or offsite to personnel and the environment.

  8. Prevention of postoperative tooth sensitivity: a preliminary clinical trial.

    Science.gov (United States)

    Sobral, M A P; Garone-Netto, N; Luz, M A A C; Santos, A P

    2005-09-01

    The purpose of this study was to evaluate clinically the effects of pre-treatments with a 35% hydroxyethyl metacrylate/5% glutaraldehyde dentine desensitizer (Gluma Desensitizer) and a 2% chlorexidine-based cavity disinfectant (Cav-Clean) on postoperative sensitivity. Three premolar teeth with no pain symptoms were selected from each one of 17 patients, totalling 51 teeth, for which Class II restoration using a composite was indicated. Each one of the three premolar teeth of the same patient was submitted to a different treatment. After acid etching, only a dental adhesive was applied to the first tooth, which served as the control. Gluma Desensitizer dentinal desensitizer was applied to the second premolar tooth prior to applying the dental adhesive. Cav-Clean cavity disinfectant was used on the third premolar tooth before applying the dental adhesive. Only one tooth was restored per session, and all premolar teeth were restored with a condensable composite, according to current restoration technique guidelines. Sensitivity to different stimuli (cold, heat, sweet and dental floss) was assessed on Day 1, Day 4 and Day 7 by questionnaire following restorative procedures. The results of this clinical research showed that, as far as the investigated stimuli and postoperative course are concerned, there was no statistically significant difference in the three different treatments (P>0.05). Postoperative sensitivity resulting from Class II restorations using composite resin cannot be completely eliminated with the prior use of a dentinal desensitizer or a cavity disinfectant. In day-to-day clinical treatment, postoperative sensitivity may possibly be related to the technique employed.

  9. Repository Subsurface Preliminary Fire Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Richard C. Logan

    2001-07-30

    This fire hazard analysis identifies preliminary design and operations features, fire, and explosion hazards, and provides a reasonable basis to establish the design requirements of fire protection systems during development and emplacement phases of the subsurface repository. This document follows the Technical Work Plan (TWP) (CRWMS M&O 2001c) which was prepared in accordance with AP-2.21Q, ''Quality Determinations and Planning for Scientific, Engineering, and Regulatory Compliance Activities''; Attachment 4 of AP-ESH-008, ''Hazards Analysis System''; and AP-3.11Q, ''Technical Reports''. The objective of this report is to establish the requirements that provide for facility nuclear safety and a proper level of personnel safety and property protection from the effects of fire and the adverse effects of fire-extinguishing agents.

  10. Towards More Efficient and Effective Global Sensitivity Analysis

    Science.gov (United States)

    Razavi, Saman; Gupta, Hoshin

    2014-05-01

    Sensitivity analysis (SA) is an important paradigm in the context of model development and application. There are a variety of approaches towards sensitivity analysis that formally describe different "intuitive" understandings of the sensitivity of a single or multiple model responses to different factors such as model parameters or forcings. These approaches are based on different philosophies and theoretical definitions of sensitivity and range from simple local derivatives to rigorous Sobol-type analysis-of-variance approaches. In general, different SA methods focus and identify different properties of the model response and may lead to different, sometimes even conflicting conclusions about the underlying sensitivities. This presentation revisits the theoretical basis for sensitivity analysis, critically evaluates the existing approaches in the literature, and demonstrates their shortcomings through simple examples. Important properties of response surfaces that are associated with the understanding and interpretation of sensitivities are outlined. A new approach towards global sensitivity analysis is developed that attempts to encompass the important, sensitivity-related properties of response surfaces. Preliminary results show that the new approach is superior to the standard approaches in the literature in terms of effectiveness and efficiency.

  11. Economic modeling and sensitivity analysis.

    Science.gov (United States)

    Hay, J W

    1998-09-01

    The field of pharmacoeconomics (PE) faces serious concerns of research credibility and bias. The failure of researchers to reproduce similar results in similar settings, the inappropriate use of clinical data in economic models, the lack of transparency, and the inability of readers to make meaningful comparisons across published studies have greatly contributed to skepticism about the validity, reliability, and relevance of these studies to healthcare decision-makers. Using a case study in the field of lipid PE, two suggestions are presented for generally applicable reporting standards that will improve the credibility of PE. Health economists and researchers should be expected to provide either the software used to create their PE model or a multivariate sensitivity analysis of their PE model. Software distribution would allow other users to validate the assumptions and calculations of a particular model and apply it to their own circumstances. Multivariate sensitivity analysis can also be used to present results in a consistent and meaningful way that will facilitate comparisons across the PE literature. Using these methods, broader acceptance and application of PE results by policy-makers would become possible. To reduce the uncertainty about what is being accomplished with PE studies, it is recommended that these guidelines become requirements of both scientific journals and healthcare plan decision-makers. The standardization of economic modeling in this manner will increase the acceptability of pharmacoeconomics as a practical, real-world science.

  12. Carbon dioxide capture processes: Simulation, design and sensitivity analysis

    DEFF Research Database (Denmark)

    Zaman, Muhammad; Lee, Jay Hyung; Gani, Rafiqul

    2012-01-01

    performance of the process to the L/G ratio to the absorber, CO2 lean solvent loadings, and striper pressure are presented in this paper. Based on the sensitivity analysis process optimization problems have been defined and solved and, a preliminary control structure selection has been made.......Carbon dioxide is the main greenhouse gas and its major source is combustion of fossil fuels for power generation. The objective of this study is to carry out the steady-state sensitivity analysis for chemical absorption of carbon dioxide capture from flue gas using monoethanolamine solvent. First...

  13. Carbon dioxide capture processes: Simulation, design and sensitivity analysis

    DEFF Research Database (Denmark)

    Zaman, Muhammad; Lee, Jay Hyung; Gani, Rafiqul

    2012-01-01

    performance of the process to the L/G ratio to the absorber, CO2 lean solvent loadings, and striper pressure are presented in this paper. Based on the sensitivity analysis process optimization problems have been defined and solved and, a preliminary control structure selection has been made.......Carbon dioxide is the main greenhouse gas and its major source is combustion of fossil fuels for power generation. The objective of this study is to carry out the steady-state sensitivity analysis for chemical absorption of carbon dioxide capture from flue gas using monoethanolamine solvent. First...

  14. BASE Flexible Array Preliminary Lithospheric Structure Analysis

    Science.gov (United States)

    Yeck, W. L.; Sheehan, A. F.; Anderson, M. L.; Siddoway, C. S.; Erslev, E.; Harder, S. H.; Miller, K. C.

    2009-12-01

    The Bighorns Arch Seismic Experiment (BASE) is a Flexible Array experiment integrated with EarthScope. The goal of BASE is to develop a better understanding of how basement-involved foreland arches form and what their link is to plate tectonic processes. To achieve this goal, the crustal structure under the Bighorn Mountain range, Bighorn Basin, and Powder River Basin of northern Wyoming and southern Montana are investigated through the deployment of 35 broadband seismometers, 200 short period seismometers, 1600 “Texan” instruments using active sources and 800 “Texan” instruments monitoring passive sources, together with field structural analysis of brittle structures. The novel combination of these approaches and anticipated simultaneous data inversion will give a detailed structural crustal image of the Bighorn region at all levels of the crust. Four models have been proposed for the formation of the Bighorn foreland arch: subhorizontal detachment within the crust, lithospheric buckling, pure shear lithospheric thickening, and fault blocks defined by lithosphere-penetrating thrust faults. During the summer of 2009, we deployed 35 broadband instruments, which have already recorded several magnitude 7+ teleseismic events. Through P wave receiver function analysis of these 35 stations folded in with many EarthScope Transportable Array stations in the region, we present a preliminary map of the Mohorovicic discontinuity. This crustal map is our first test of how the unique Moho geometries predicted by the four hypothesized models of basement involved arches fit seismic observations for the Bighorn Mountains. In addition, shear-wave splitting analysis for our first few recorded teleseisms helps us determine if strong lithospheric deformation is preserved under the range. These analyses help lead us to our final goal, a complete 4D (3D spatial plus temporal) lithospheric-scale model of arch formation which will advance our understanding of the mechanisms

  15. Sensitivity Analysis of Multidisciplinary Rotorcraft Simulations

    Science.gov (United States)

    Wang, Li; Diskin, Boris; Biedron, Robert T.; Nielsen, Eric J.; Bauchau, Olivier A.

    2017-01-01

    A multidisciplinary sensitivity analysis of rotorcraft simulations involving tightly coupled high-fidelity computational fluid dynamics and comprehensive analysis solvers is presented and evaluated. An unstructured sensitivity-enabled Navier-Stokes solver, FUN3D, and a nonlinear flexible multibody dynamics solver, DYMORE, are coupled to predict the aerodynamic loads and structural responses of helicopter rotor blades. A discretely-consistent adjoint-based sensitivity analysis available in FUN3D provides sensitivities arising from unsteady turbulent flows and unstructured dynamic overset meshes, while a complex-variable approach is used to compute DYMORE structural sensitivities with respect to aerodynamic loads. The multidisciplinary sensitivity analysis is conducted through integrating the sensitivity components from each discipline of the coupled system. Numerical results verify accuracy of the FUN3D/DYMORE system by conducting simulations for a benchmark rotorcraft test model and comparing solutions with established analyses and experimental data. Complex-variable implementation of sensitivity analysis of DYMORE and the coupled FUN3D/DYMORE system is verified by comparing with real-valued analysis and sensitivities. Correctness of adjoint formulations for FUN3D/DYMORE interfaces is verified by comparing adjoint-based and complex-variable sensitivities. Finally, sensitivities of the lift and drag functions obtained by complex-variable FUN3D/DYMORE simulations are compared with sensitivities computed by the multidisciplinary sensitivity analysis, which couples adjoint-based flow and grid sensitivities of FUN3D and FUN3D/DYMORE interfaces with complex-variable sensitivities of DYMORE structural responses.

  16. Sensitivity Analysis of Component Reliability

    Institute of Scientific and Technical Information of China (English)

    ZhenhuaGe

    2004-01-01

    In a system, Every component has its unique position within system and its unique failure characteristics. When a component's reliability is changed, its effect on system reliability is not equal. Component reliability sensitivity is a measure of effect on system reliability while a component's reliability is changed. In this paper, the definition and relative matrix of component reliability sensitivity is proposed, and some of their characteristics are analyzed. All these will help us to analyse or improve the system reliability.

  17. Dual-fuel, dual-throat engine preliminary analysis

    Science.gov (United States)

    Obrien, C. J.

    1979-01-01

    A propulsion system analysis of the dual fuel, dual throat engine for launch vehicle applications was conducted. Basic dual throat engine characterization data were obtained to allow vehicle optimization studies to be conducted. A preliminary baseline engine system was defined.

  18. Shape design sensitivity analysis using domain information

    Science.gov (United States)

    Seong, Hwal-Gyeong; Choi, Kyung K.

    1985-01-01

    A numerical method for obtaining accurate shape design sensitivity information for built-up structures is developed and demonstrated through analysis of examples. The basic character of the finite element method, which gives more accurate domain information than boundary information, is utilized for shape design sensitivity improvement. A domain approach for shape design sensitivity analysis of built-up structures is derived using the material derivative idea of structural mechanics and the adjoint variable method of design sensitivity analysis. Velocity elements and B-spline curves are introduced to alleviate difficulties in generating domain velocity fields. The regularity requirements of the design velocity field are studied.

  19. Sensitivity Analysis for Multidisciplinary Systems (SAMS)

    Science.gov (United States)

    2016-12-01

    AFRL-RQ-WP-TM-2017-0017 SENSITIVITY ANALYSIS FOR MULTIDISCIPLINARY SYSTEMS (SAMS) Richard D. Snyder Design & Analysis Branch Aerospace Vehicles...for public release. Distribution is unlimited. 1 AFRL-NASA Collaboration Provide economical, accurate sensitivities for multidisciplinary design and... Concept Refinement Technology Development System Development & Demonstration Production & Deployment Operation & Support • Knowledge is most limited

  20. Object-sensitive Type Analysis of PHP

    NARCIS (Netherlands)

    Van der Hoek, Henk Erik; Hage, J

    2015-01-01

    In this paper we develop an object-sensitive type analysis for PHP, based on an extension of the notion of monotone frameworks to deal with the dynamic aspects of PHP, and following the framework of Smaragdakis et al. for object-sensitive analysis. We consider a number of instantiations of the frame

  1. [Tuscan Chronic Care Model: a preliminary analysis].

    Science.gov (United States)

    Barbato, Angelo; Meggiolaro, Angela; Rossi, Luigi; Fioravanti, C; Palermita, F; La Torre, Giuseppe

    2015-01-01

    the aim of this study is to present a preliminary analysis of efficacy and effectiveness of a model of chronically ill care (Chronic Care Model, CCM). the analysis took into account 106 territorial modules, 1016 General Practitioners and 1,228,595 patients. The diagnostic and therapeutic pathways activated (PDTA), involved four chronic conditions, selected according to the prevalence and incidence, in Tuscany Region: Diabetes Mellitus (DM), Heart Failure (SC), Chronic Obstructive Pulmonary Disease (COPD) and stroke. Six epidemiological indicators of process and output were selected, in order to measure the model of care performed, before and after its application: adherence to specific follow-up for each pathology (use of clinical and laboratory indicators), annual average of expenditure per/capita/euro for diagnostic tests, in laboratory and instrumental, average expenditure per/capita/year for specialist visits; hospitalization rate for diseases related to the main pathology, hospitalization rate for long-term complications and rate of access to the emergency department (ED). Data were collected through the database; the differences before and after the intervention and between exposed and unexposed, were analyzed by method "Before-After (Controlled and Uncontrolled) Studies". The impact of the intervention was calculated as DD (difference of the differences). DM management showed an increased adhesion to follow-up (DD: +8.1%), and the use of laboratory diagnostics (DD: +4,9 €/year/pc), less hospitalization for long-term complications and for endocrine related diseases (DD respectively: 5.8/1000 and DD: +1.2/1000), finally a smaller increase of access to PS (DD: -1.6/1000), despite a slight increase of specialistic visits (DD: +0,38 €/year/pc). The management of SC initially showed a rising adherence to follow-up (DD: +2.3%), a decrease of specialist visits (DD:E 1.03 €/year/pc), hospitalization and access to PS for exacerbations (DD: -4.4/1000 and DD: -6

  2. Extended Forward Sensitivity Analysis for Uncertainty Quantification

    Energy Technology Data Exchange (ETDEWEB)

    Haihua Zhao; Vincent A. Mousseau

    2008-09-01

    This report presents the forward sensitivity analysis method as a means for quantification of uncertainty in system analysis. The traditional approach to uncertainty quantification is based on a “black box” approach. The simulation tool is treated as an unknown signal generator, a distribution of inputs according to assumed probability density functions is sent in and the distribution of the outputs is measured and correlated back to the original input distribution. This approach requires large number of simulation runs and therefore has high computational cost. Contrary to the “black box” method, a more efficient sensitivity approach can take advantage of intimate knowledge of the simulation code. In this approach equations for the propagation of uncertainty are constructed and the sensitivity is solved for as variables in the same simulation. This “glass box” method can generate similar sensitivity information as the above “black box” approach with couples of runs to cover a large uncertainty region. Because only small numbers of runs are required, those runs can be done with a high accuracy in space and time ensuring that the uncertainty of the physical model is being measured and not simply the numerical error caused by the coarse discretization. In the forward sensitivity method, the model is differentiated with respect to each parameter to yield an additional system of the same size as the original one, the result of which is the solution sensitivity. The sensitivity of any output variable can then be directly obtained from these sensitivities by applying the chain rule of differentiation. We extend the forward sensitivity method to include time and spatial steps as special parameters so that the numerical errors can be quantified against other physical parameters. This extension makes the forward sensitivity method a much more powerful tool to help uncertainty analysis. By knowing the relative sensitivity of time and space steps with other

  3. Sensitivity analysis for large-scale problems

    Science.gov (United States)

    Noor, Ahmed K.; Whitworth, Sandra L.

    1987-01-01

    The development of efficient techniques for calculating sensitivity derivatives is studied. The objective is to present a computational procedure for calculating sensitivity derivatives as part of performing structural reanalysis for large-scale problems. The scope is limited to framed type structures. Both linear static analysis and free-vibration eigenvalue problems are considered.

  4. An ESDIRK Method with Sensitivity Analysis Capabilities

    DEFF Research Database (Denmark)

    Kristensen, Morten Rode; Jørgensen, John Bagterp; Thomsen, Per Grove

    2004-01-01

    A new algorithm for numerical sensitivity analysis of ordinary differential equations (ODEs) is presented. The underlying ODE solver belongs to the Runge-Kutta family. The algorithm calculates sensitivities with respect to problem parameters and initial conditions, exploiting the special structure...

  5. Extended Forward Sensitivity Analysis for Uncertainty Quantification

    Energy Technology Data Exchange (ETDEWEB)

    Haihua Zhao; Vincent A. Mousseau

    2011-09-01

    Verification and validation (V&V) are playing more important roles to quantify uncertainties and realize high fidelity simulations in engineering system analyses, such as transients happened in a complex nuclear reactor system. Traditional V&V in the reactor system analysis focused more on the validation part or did not differentiate verification and validation. The traditional approach to uncertainty quantification is based on a 'black box' approach. The simulation tool is treated as an unknown signal generator, a distribution of inputs according to assumed probability density functions is sent in and the distribution of the outputs is measured and correlated back to the original input distribution. The 'black box' method mixes numerical errors with all other uncertainties. It is also not efficient to perform sensitivity analysis. Contrary to the 'black box' method, a more efficient sensitivity approach can take advantage of intimate knowledge of the simulation code. In these types of approaches equations for the propagation of uncertainty are constructed and the sensitivities are directly solved for as variables in the simulation. This paper presents the forward sensitivity analysis as a method to help uncertainty qualification. By including time step and potentially spatial step as special sensitivity parameters, the forward sensitivity method is extended as one method to quantify numerical errors. Note that by integrating local truncation errors over the whole system through the forward sensitivity analysis process, the generated time step and spatial step sensitivity information reflect global numerical errors. The discretization errors can be systematically compared against uncertainties due to other physical parameters. This extension makes the forward sensitivity method a much more powerful tool to help uncertainty qualification. By knowing the relative sensitivity of time and space steps with other interested physical

  6. Preliminary Sensitivity Study of Upper Head Nodalization for LBLOCA in APR-1400

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Dong Gu; Yoo, Seung Hun; Cho, Dae-Hyung [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2015-10-15

    In this study, the key-way bypass was determined to be - 0.3 %. The steady state condition which is the initial condition for LBLOCA was obtained by MARS-KS calculation. Up to now, it was assumed that the temperature of the upper dome in APR-1400 was close to that of the cold leg. However, it was found that the temperature of the upper head/dome might be a little lower than or similar to that of the hot leg through the evaluation of the detailed design data. Since the higher upper head temperature affects blowdown quenching and peak cladding temperature in the reflood phase, the nodalization for upper head should be modified. In this study, the preliminary sensitivity study of original and modified nodalization for LBLOCA was performed, and the effect of upper head nodalization and temperature was evaluated qualitatively. In this study, the preliminary sensitivity study of original and modified nodalization for upper head in APR-1400 was performed, and the effect of upper head nodalization and temperature on LBLOCA PCT was evaluated qualitatively. Through the transient calculation, it was confirmed that the upper head temperature affects the water inventory in the upper head at the early stage of LBLOCA so it does the blowdown quenching and following reflood PCT significantly. The results in this study were caused by very conservative upper head temperature determination.

  7. Analysis of MEMS Accelerometer for Optimized Sensitivity

    National Research Council Canada - National Science Library

    Khairun Nisa Khamil; Kok Swee Leong; Norizan Bin Mohamad; Norhayati Soin; Norshahida Saba

    2014-01-01

    .... The geometrical of the accelerometer, mass width, beam (length and width) of the device and its sensitivity are analyzed theoretically and also using finite element analysis software, COMSOL Multiphysics...

  8. Sensitivity Analysis Using Simple Additive Weighting Method

    Directory of Open Access Journals (Sweden)

    Wayne S. Goodridge

    2016-05-01

    Full Text Available The output of a multiple criteria decision method often has to be analyzed using some sensitivity analysis technique. The SAW MCDM method is commonly used in management sciences and there is a critical need for a robust approach to sensitivity analysis in the context that uncertain data is often present in decision models. Most of the sensitivity analysis techniques for the SAW method involve Monte Carlo simulation methods on the initial data. These methods are computationally intensive and often require complex software. In this paper, the SAW method is extended to include an objective function which makes it easy to analyze the influence of specific changes in certain criteria values thus making easy to perform sensitivity analysis.

  9. Multiple predictor smoothing methods for sensitivity analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Helton, Jon Craig; Storlie, Curtis B.

    2006-08-01

    The use of multiple predictor smoothing methods in sampling-based sensitivity analyses of complex models is investigated. Specifically, sensitivity analysis procedures based on smoothing methods employing the stepwise application of the following nonparametric regression techniques are described: (1) locally weighted regression (LOESS), (2) additive models, (3) projection pursuit regression, and (4) recursive partitioning regression. The indicated procedures are illustrated with both simple test problems and results from a performance assessment for a radioactive waste disposal facility (i.e., the Waste Isolation Pilot Plant). As shown by the example illustrations, the use of smoothing procedures based on nonparametric regression techniques can yield more informative sensitivity analysis results than can be obtained with more traditional sensitivity analysis procedures based on linear regression, rank regression or quadratic regression when nonlinear relationships between model inputs and model predictions are present.

  10. Preliminary safety design analysis of KALIMER

    Energy Technology Data Exchange (ETDEWEB)

    Suk, Soo Dong; Kwon, Y. M.; Kim, K. D. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-03-01

    The national long-term R and D program updated in 1997 requires Korea Atomic Energy Research Institute(KAERI) to complete by the year 2006 the basic design of Korea Advanced Liquid Metal Reactor (KALIMER), along with supporting R and D work, with the capability of resolving the issue of spent fuel storage as well as with significantly enhanced safety. KALIMER is a 150 MWe pool-type sodium cooled prototype reactor that uses metallic fuel. The conceptual design is currently under way to establish a self consistent design meeting a set of the major safety design requirements for accident prevention. Some of current emphasis include those for inherent and passive means of negative reactivity insertion and decay heat removal, high shutdown reliability, prevention of and protection from sodium chemical reaction, and high seismic margin, among others. All of these requirements affect the reactor design significantly and involve supporting R and D programs of substance. This document first introduces a set of safety design requirements and accident evaluation criteria established for the conceptual design of KALIMER and then summarizes some of the preliminary results of engineering and design analyses performed for the safety of KALIMER. 19 refs., 19 figs., 6 tabs. (Author)

  11. Effects of sensitive electrical stimulation based cueing in Parkinson's disease: a preliminary study

    Directory of Open Access Journals (Sweden)

    Benoît Sijobert

    2016-06-01

    Full Text Available This study aims to investigate the effect of a sensitive cueing on Freezing of Gait (FOG and gait disorders in subjects suffering from Parkinson’s disease (PD. 13 participants with Parkinson’s disease were equipped with an electrical stimulator and a foot mounted inertial measurement unit (IMU. An IMU based algorithm triggered in real time an electrical stimulus applied on the arch of foot at heel off detection. Starting from standing, subjects were asked to walk at their preferred speed on a path comprising 5m straight, u-turn and walk around tasks. Cueing globally decreased the time to achieve the different tasks in all the subjects. In “freezer” subjects, the time to complete the entire path was reduced by 19%. FOG events occurrence was lowered by 12% compared to baseline before and after cueing. This preliminary work showed a positive global effect of an electrical stimulation based cueing on gait and FOG in PD.

  12. Preliminary analysis of patent trends for magnetic fusion technology

    Energy Technology Data Exchange (ETDEWEB)

    Levine, L.O.; Ashton, W.B.; Campbell, R.S.

    1984-02-01

    This study presents a preliminary analysis of development trends in magnetic fusion technology based on data from US patents. The research is limited to identification and description of general patent activity and ownership characteristics for 373 patents. The results suggest that more detailed studies of fusion patents could provide useful R and D planning information.

  13. Preliminary analysis of alternative fuel cycles for proliferation evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Steindler, M. J.; Ripfel, H. C.F.; Rainey, R. H.

    1977-01-01

    The ERDA Division of Nuclear Research and Applications proposed 67 nuclear fuel cycles for assessment as to their nonproliferation potential. The object of the assessment was to determine which fuel cycles pose inherently low risk for nuclear weapon proliferation while retaining the major benefits of nuclear energy. This report is a preliminary analysis of these fuel cycles to develop the fuel-recycle data that will complement reactor data, environmental data, and political considerations, which must be included in the overall evaluation. This report presents the preliminary evaluations from ANL, HEDL, ORNL, and SRL and is the basis for a continuing in-depth study. (DLC)

  14. Eigenfrequency sensitivity analysis of flexible rotors

    Directory of Open Access Journals (Sweden)

    Šašek J.

    2007-10-01

    Full Text Available This paper deals with sensitivity analysis of eigenfrequencies from the viewpoint of design parameters. The sensitivity analysis is applied to a rotor which consists of a shaft and a disk. The design parameters of sensitivity analysis are the disk radius and the disk width. The shaft is modeled as a 1D continuum using shaft finite elements. The disks of rotating systems are commonly modeled as rigid bodies. The presented approach to the disk modeling is based on a 3D flexible continuum discretized using hexahedral finite elements. The both components of the rotor are connected together by special proposed couplings. The whole rotor is modeled in rotating coordinate system with considering rotation influences (gyroscopic and dynamics stiffness matrices.

  15. Sensitivity analysis and application in exploration geophysics

    Science.gov (United States)

    Tang, R.

    2013-12-01

    In exploration geophysics, the usual way of dealing with geophysical data is to form an Earth model describing underground structure in the area of investigation. The resolved model, however, is based on the inversion of survey data which is unavoidable contaminated by various noises and is sampled in a limited number of observation sites. Furthermore, due to the inherent non-unique weakness of inverse geophysical problem, the result is ambiguous. And it is not clear that which part of model features is well-resolved by the data. Therefore the interpretation of the result is intractable. We applied a sensitivity analysis to address this problem in magnetotelluric(MT). The sensitivity, also named Jacobian matrix or the sensitivity matrix, is comprised of the partial derivatives of the data with respect to the model parameters. In practical inversion, the matrix can be calculated by direct modeling of the theoretical response for the given model perturbation, or by the application of perturbation approach and reciprocity theory. We now acquired visualized sensitivity plot by calculating the sensitivity matrix and the solution is therefore under investigation that the less-resolved part is indicated and should not be considered in interpretation, while the well-resolved parameters can relatively be convincing. The sensitivity analysis is hereby a necessary and helpful tool for increasing the reliability of inverse models. Another main problem of exploration geophysics is about the design strategies of joint geophysical survey, i.e. gravity, magnetic & electromagnetic method. Since geophysical methods are based on the linear or nonlinear relationship between observed data and subsurface parameters, an appropriate design scheme which provides maximum information content within a restricted budget is quite difficult. Here we firstly studied sensitivity of different geophysical methods by mapping the spatial distribution of different survey sensitivity with respect to the

  16. Preliminary Integrated Safety Analysis Status Report

    Energy Technology Data Exchange (ETDEWEB)

    D. Gwyn

    2001-04-01

    This report provides the status of the potential Monitored Geologic Repository (MGR) Integrated Safety Analysis (EA) by identifying the initial work scope scheduled for completion during the ISA development period, the schedules associated with the tasks identified, safety analysis issues encountered, and a summary of accomplishments during the reporting period. This status covers the period from October 1, 2000 through March 30, 2001.

  17. A numerical comparison of sensitivity analysis techniques

    Energy Technology Data Exchange (ETDEWEB)

    Hamby, D.M.

    1993-12-31

    Engineering and scientific phenomena are often studied with the aid of mathematical models designed to simulate complex physical processes. In the nuclear industry, modeling the movement and consequence of radioactive pollutants is extremely important for environmental protection and facility control. One of the steps in model development is the determination of the parameters most influential on model results. A {open_quotes}sensitivity analysis{close_quotes} of these parameters is not only critical to model validation but also serves to guide future research. A previous manuscript (Hamby) detailed many of the available methods for conducting sensitivity analyses. The current paper is a comparative assessment of several methods for estimating relative parameter sensitivity. Method practicality is based on calculational ease and usefulness of the results. It is the intent of this report to demonstrate calculational rigor and to compare parameter sensitivity rankings resulting from various sensitivity analysis techniques. An atmospheric tritium dosimetry model (Hamby) is used here as an example, but the techniques described can be applied to many different modeling problems. Other investigators (Rose; Dalrymple and Broyd) present comparisons of sensitivity analyses methodologies, but none as comprehensive as the current work.

  18. SENSITIVITY ANALYSIS FOR PARAMETERIZED VARIATIONAL INEQUALITY PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Li Fei

    2004-01-01

    This paper presents sensitivity analysis for parameterized variational inequality problems (VIP). Under appropriate assumption, it is shown that the perturbed solution to parameterized VIP is existent, unique, continuous and differentiable with respect to perturbation parameter. In the case of differentiability, we derive the equations forcalculating the derivative of solution variables with respect to the perturbation parameters.

  19. Yucca Mountain transportation routes: Preliminary characterization and risk analysis; Volume 2, Figures [and] Volume 3, Technical Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Souleyrette, R.R. II; Sathisan, S.K.; di Bartolo, R. [Nevada Univ., Las Vegas, NV (United States). Transportation Research Center

    1991-05-31

    This report presents appendices related to the preliminary assessment and risk analysis for high-level radioactive waste transportation routes to the proposed Yucca Mountain Project repository. Information includes data on population density, traffic volume, ecologically sensitive areas, and accident history.

  20. Yucca Mountain transportation routes: Preliminary characterization and risk analysis; Volume 2, Figures [and] Volume 3, Technical Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Souleyrette, R.R. II; Sathisan, S.K.; di Bartolo, R. [Nevada Univ., Las Vegas, NV (United States). Transportation Research Center

    1991-05-31

    This report presents appendices related to the preliminary assessment and risk analysis for high-level radioactive waste transportation routes to the proposed Yucca Mountain Project repository. Information includes data on population density, traffic volume, ecologically sensitive areas, and accident history.

  1. Fort Drum Preliminary Fiscal Impact Analysis.

    Science.gov (United States)

    1986-02-01

    of inmigrants 0 Fiscal histories, projections, and impacts for counties, cities, towns, villages, school districts, and the state. The results of...distribution of the inmigrating population within the three counties. Thus, an accurate forecast of the expected distribution of the inmigrating population is a...The distribution of inmigration to the school districts was made using the analysis explained in Chapter 3. Children associated with 800 new on-post

  2. Preliminary Analysis of the Multisphere Neutron Spectrometer

    Science.gov (United States)

    Goldhagen, P.; Kniss, T.; Wilson, J. W.; Singleterry, R. C.; Jones, I. W.; VanSteveninck, W.

    2003-01-01

    Crews working on present-day jet aircraft are a large occupationally exposed group with a relatively high average effective dose from galactic cosmic radiation. Crews of future high-speed commercial aircraft flying at higher altitudes would be even more exposed. To help reduce the significant uncertainties in calculations of such exposures, the Atmospheric Ionizing Radiation (AIR) Project, an international collaboration of 15 laboratories, made simultaneous radiation measurements with 14 instruments on five flights of a NASA ER-2 high-altitude aircraft. The primary AIR instrument was a highly sensitive extended-energy multisphere neutron spectrometer with lead and steel shells placed within the moderators of two of its 14 detectors to enhance response at high energies. Detector responses were calculated for neutrons and charged hadrons at energies up to 100 GeV using MCNPX. Neutron spectra were unfolded from the measured count rates using the new MAXED code. We have measured the cosmic-ray neutron spectrum (thermal to greater than 10 GeV), total neutron fluence rate, and neutron effective dose and dose equivalent rates and their dependence on altitude and geomagnetic cutoff. The measured cosmic-ray neutron spectra have almost no thermal neutrons, a large "evaporation" peak near 1 MeV and a second broad peak near 100 MeV which contributes about 69% of the neutron effective dose. At high altitude, geomagnetic latitude has very little effect on the shape of the spectrum, but it is the dominant variable affecting neutron fluence rate, which was 8 times higher at the northernmost measurement location than it was at the southernmost. The shape of the spectrum varied only slightly with altitude from 21 km down to 12 km (56 - 201 grams per square centimeter atmospheric depth), but was significantly different on the ground. In all cases, ambient dose equivalent was greater than effective dose for cosmic-ray neutrons.

  3. Sensitivity analysis and related analysis : A survey of statistical techniques

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    1995-01-01

    This paper reviews the state of the art in five related types of analysis, namely (i) sensitivity or what-if analysis, (ii) uncertainty or risk analysis, (iii) screening, (iv) validation, and (v) optimization. The main question is: when should which type of analysis be applied; which statistical

  4. NIR sensitivity analysis with the VANE

    Science.gov (United States)

    Carrillo, Justin T.; Goodin, Christopher T.; Baylot, Alex E.

    2016-05-01

    Near infrared (NIR) cameras, with peak sensitivity around 905-nm wavelengths, are increasingly used in object detection applications such as pedestrian detection, occupant detection in vehicles, and vehicle detection. In this work, we present the results of simulated sensitivity analysis for object detection with NIR cameras. The analysis was conducted using high performance computing (HPC) to determine the environmental effects on object detection in different terrains and environmental conditions. The Virtual Autonomous Navigation Environment (VANE) was used to simulate highresolution models for environment, terrain, vehicles, and sensors. In the experiment, an active fiducial marker was attached to the rear bumper of a vehicle. The camera was mounted on a following vehicle that trailed at varying standoff distances. Three different terrain conditions (rural, urban, and forest), two environmental conditions (clear and hazy), three different times of day (morning, noon, and evening), and six different standoff distances were used to perform the sensor sensitivity analysis. The NIR camera that was used for the simulation is the DMK firewire monochrome on a pan-tilt motor. Standoff distance was varied along with environment and environmental conditions to determine the critical failure points for the sensor. Feature matching was used to detect the markers in each frame of the simulation, and the percentage of frames in which one of the markers was detected was recorded. The standoff distance produced the biggest impact on the performance of the camera system, while the camera system was not sensitive to environment conditions.

  5. Preliminary analysis of turbochargers rotors dynamic behaviour

    Science.gov (United States)

    Monoranu, R.; Ştirbu, C.; Bujoreanu, C.

    2016-08-01

    Turbocharger rotors for the spark and compression ignition engines are resistant steels manufactured in order to support the exhaust gas temperatures exceeding 1200 K. In fact, the mechanical stress is not large as the power consumption of these systems is up to 10 kW, but the operating speeds are high, ranging between 30000 ÷ 250000 rpm. Therefore, the correct turbochargers functioning involves, even from the design stage, the accurate evaluation of the temperature effects, of the turbine torque due to the engine exhaust gases and of the vibration system behaviour caused by very high operating speeds. In addition, the turbocharger lubrication complicates the model, because the classical hydrodynamic theory cannot be applied to evaluate the floating bush bearings. The paper proposes a FEM study using CATIA environment, both as modeling medium and as tool for the numerical analysis, in order to highlight the turbocharger complex behaviour. An accurate design may prevent some major issues which can occur during its operation.

  6. A Monte Carlo/response surface strategy for sensitivity analysis: application to a dynamic model of vegetative plant growth

    Science.gov (United States)

    Lim, J. T.; Gold, H. J.; Wilkerson, G. G.; Raper, C. D. Jr; Raper CD, J. r. (Principal Investigator)

    1989-01-01

    We describe the application of a strategy for conducting a sensitivity analysis for a complex dynamic model. The procedure involves preliminary screening of parameter sensitivities by numerical estimation of linear sensitivity coefficients, followed by generation of a response surface based on Monte Carlo simulation. Application is to a physiological model of the vegetative growth of soybean plants. The analysis provides insights as to the relative importance of certain physiological processes in controlling plant growth. Advantages and disadvantages of the strategy are discussed.

  7. Preliminary Analysis of Helicopter Options to Support Tunisian Counterterrorism Operations

    Science.gov (United States)

    2016-04-27

    results of the current analysis and in Mouton et al., 2015, is the relative cost -effectiveness between the CH-47D and the Mi-17v5. In the previous...helicopters from Sikorsky to fulfill a number of roles in counterterrorism operations. Rising costs and delays in delivery raised the question of...whether other cost -effective options exist to meet Tunisia’s helicopter requirement. Approach Our team conducted a preliminary assessment of

  8. Reliability Sensitivity Analysis for Location Scale Family

    Institute of Scientific and Technical Information of China (English)

    洪东跑; 张海瑞

    2011-01-01

    Many products always operate under various complex environment conditions. To describe the dynamic influence of environment factors on their reliability, a method of reliability sensitivity analysis is proposed. In this method, the location parameter is assumed as a function of relevant environment variables while the scale parameter is assumed as an un- known positive constant. Then, the location parameter function is constructed by using the method of radial basis function. Using the varied environment test data, the log-likelihood function is transformed to a generalized linear expression by de- scribing the indicator as Poisson variable. With the generalized linear model, the maximum likelihood estimations of the model coefficients are obtained. With the reliability model, the reliability sensitivity is obtained. An instance analysis shows that the method is feasible to analyze the dynamic variety characters of reliability along with environment factors and is straightforward for engineering application.

  9. Demonstration sensitivity analysis for RADTRAN III

    Energy Technology Data Exchange (ETDEWEB)

    Neuhauser, K S; Reardon, P C

    1986-10-01

    A demonstration sensitivity analysis was performed to: quantify the relative importance of 37 variables to the total incident free dose; assess the elasticity of seven dose subgroups to those same variables; develop density distributions for accident dose to combinations of accident data under wide-ranging variations; show the relationship between accident consequences and probabilities of occurrence; and develop limits for the variability of probability consequence curves.

  10. Sensitivity Analysis of Fire Dynamics Simulation

    DEFF Research Database (Denmark)

    Brohus, Henrik; Nielsen, Peter V.; Petersen, Arnkell J.

    2007-01-01

    equations require solution of the issues of combustion and gas radiation to mention a few. This paper performs a sensitivity analysis of a fire dynamics simulation on a benchmark case where measurement results are available for comparison. The analysis is performed using the method of Elementary Effects......In case of fire dynamics simulation requirements to reliable results are most often very high due to the severe consequences of erroneous results. At the same time it is a well known fact that fire dynamics simulation constitutes rather complex physical phenomena which apart from flow and energy...

  11. Sensitivity analysis of numerical model of prestressed concrete containment

    Energy Technology Data Exchange (ETDEWEB)

    Bílý, Petr, E-mail: petr.bily@fsv.cvut.cz; Kohoutková, Alena, E-mail: akohout@fsv.cvut.cz

    2015-12-15

    Graphical abstract: - Highlights: • FEM model of prestressed concrete containment with steel liner was created. • Sensitivity analysis of changes in geometry and loads was conducted. • Steel liner and temperature effects are the most important factors. • Creep and shrinkage parameters are essential for the long time analysis. • Prestressing schedule is a key factor in the early stages. - Abstract: Safety is always the main consideration in the design of containment of nuclear power plant. However, efficiency of the design process should be also taken into consideration. Despite the advances in computational abilities in recent years, simplified analyses may be found useful for preliminary scoping or trade studies. In the paper, a study on sensitivity of finite element model of prestressed concrete containment to changes in geometry, loads and other factors is presented. Importance of steel liner, reinforcement, prestressing process, temperature changes, nonlinearity of materials as well as density of finite elements mesh is assessed in the main stages of life cycle of the containment. Although the modeling adjustments have not produced any significant changes in computation time, it was found that in some cases simplified modeling process can lead to significant reduction of work time without degradation of the results.

  12. Sensitivity Analysis of Automated Ice Edge Detection

    Science.gov (United States)

    Moen, Mari-Ann N.; Isaksem, Hugo; Debien, Annekatrien

    2016-08-01

    The importance of highly detailed and time sensitive ice charts has increased with the increasing interest in the Arctic for oil and gas, tourism, and shipping. Manual ice charts are prepared by national ice services of several Arctic countries. Methods are also being developed to automate this task. Kongsberg Satellite Services uses a method that detects ice edges within 15 minutes after image acquisition. This paper describes a sensitivity analysis of the ice edge, assessing to which ice concentration class from the manual ice charts it can be compared to. The ice edge is derived using the Ice Tracking from SAR Images (ITSARI) algorithm. RADARSAT-2 images of February 2011 are used, both for the manual ice charts and the automatic ice edges. The results show that the KSAT ice edge lies within ice concentration classes with very low ice concentration or open water.

  13. The sensitivity analysis of population projections

    Directory of Open Access Journals (Sweden)

    Hal Caswell

    2015-10-01

    Full Text Available Background: Population projections using the cohort component method can be written as time-varyingmatrix population models. The matrices are parameterized by schedules of mortality, fertility,immigration, and emigration over the duration of the projection. A variety of dependentvariables are routinely calculated (the population vector, various weighted population sizes, dependency ratios, etc. from such projections. Objective: Our goal is to derive and apply theory to compute the sensitivity and the elasticity (proportional sensitivity of any projection outcome to changes in any of the parameters, where those changes are applied at any time during the projection interval. Methods: We use matrix calculus to derive a set of equations for the sensitivity and elasticity of any vector valued outcome ξ(t at time t to any perturbation of a parameter vector Ɵ(s at anytime s. Results: The results appear in the form of a set of dynamic equations for the derivatives that areintegrated in parallel with the dynamic equations for the projection itself. We show resultsfor single-sex projections and for the more detailed case of projections including age distributions for both sexes. We apply the results to a projection of the population of Spain, from 2012 to 2052, prepared by the Instituto Nacional de Estadística, and determine the sensitivity and elasticity of (1 total population, (2 the school-age population, (3 the population subject to dementia, (4 the total dependency ratio, and (5 the economicsupport ratio. Conclusions: Writing population projections in matrix form makes sensitivity analysis possible. Such analyses are a powerful tool for the exploration of how detailed aspects of the projectionoutput are determined by the mortality, fertility, and migration schedules that underlie theprojection.

  14. Measuring Road Network Vulnerability with Sensitivity Analysis

    Science.gov (United States)

    Jun-qiang, Leng; Long-hai, Yang; Liu, Wei-yi; Zhao, Lin

    2017-01-01

    This paper focuses on the development of a method for road network vulnerability analysis, from the perspective of capacity degradation, which seeks to identify the critical infrastructures in the road network and the operational performance of the whole traffic system. This research involves defining the traffic utility index and modeling vulnerability of road segment, route, OD (Origin Destination) pair and road network. Meanwhile, sensitivity analysis method is utilized to calculate the change of traffic utility index due to capacity degradation. This method, compared to traditional traffic assignment, can improve calculation efficiency and make the application of vulnerability analysis to large actual road network possible. Finally, all the above models and calculation method is applied to actual road network evaluation to verify its efficiency and utility. This approach can be used as a decision-supporting tool for evaluating the performance of road network and identifying critical infrastructures in transportation planning and management, especially in the resource allocation for mitigation and recovery. PMID:28125706

  15. LCA data quality: sensitivity and uncertainty analysis.

    Science.gov (United States)

    Guo, M; Murphy, R J

    2012-10-01

    Life cycle assessment (LCA) data quality issues were investigated by using case studies on products from starch-polyvinyl alcohol based biopolymers and petrochemical alternatives. The time horizon chosen for the characterization models was shown to be an important sensitive parameter for the environmental profiles of all the polymers. In the global warming potential and the toxicity potential categories the comparison between biopolymers and petrochemical counterparts altered as the time horizon extended from 20 years to infinite time. These case studies demonstrated that the use of a single time horizon provide only one perspective on the LCA outcomes which could introduce an inadvertent bias into LCA outcomes especially in toxicity impact categories and thus dynamic LCA characterization models with varying time horizons are recommended as a measure of the robustness for LCAs especially comparative assessments. This study also presents an approach to integrate statistical methods into LCA models for analyzing uncertainty in industrial and computer-simulated datasets. We calibrated probabilities for the LCA outcomes for biopolymer products arising from uncertainty in the inventory and from data variation characteristics this has enabled assigning confidence to the LCIA outcomes in specific impact categories for the biopolymer vs. petrochemical polymer comparisons undertaken. Uncertainty combined with the sensitivity analysis carried out in this study has led to a transparent increase in confidence in the LCA findings. We conclude that LCAs lacking explicit interpretation of the degree of uncertainty and sensitivities are of limited value as robust evidence for decision making or comparative assertions.

  16. Project CARDS technical information record: parametric and sensitivity analysis and determination of response spectra for horizontal, vertical and rotational motion of a radioactive material shipping package relative to the motion of its support (railcar). Part 2. Continuation of CARDS-TIR-80-3 (Preliminary)

    Energy Technology Data Exchange (ETDEWEB)

    Fields, S.R.

    1980-11-26

    The generation of the response spectra was coupled to a parametric and sensitivity analysis. Support accelerations and tiedown forces are presented as functions of time. The parametric analysis found that the horizontal acceleration of the support and the MAR (max absolute relative) horizontal acceleration are relatively insensitive, while the corresponding vertical accelerations are highly sensitive to changes in 4 of the 13 parameters, and the corresponding rotational accelerations are highly sensitive to changes in 8 of the 13 parameters. The tiedown forces are moderately sensitive to changes in 3 of the parameters. (DLC)

  17. NRT Rotor Structural / Aeroelastic Analysis for the Preliminary Design Review

    Energy Technology Data Exchange (ETDEWEB)

    Ennis, Brandon Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Paquette, Joshua A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    This document describes the initial structural design for the National Rotor Testbed blade as presented during the preliminary design review at Sandia National Laboratories on October 28- 29, 2015. The document summarizes the structural and aeroelastic requirements placed on the NRT rotor for satisfactory deployment at the DOE/SNL SWiFT experimental facility to produce high-quality datasets for wind turbine model validation. The method and result of the NRT blade structural optimization is also presented within this report, along with analysis of its satisfaction of the design requirements.

  18. Preliminary Analysis of ULPC Light Curves Using Fourier Decomposition Technique

    CERN Document Server

    Ngeow, Chow-Choong; Kanbur, Shashi; Barrett, Brittany; Lin, Bin

    2013-01-01

    Recent work on Ultra Long Period Cepheids (ULPCs) has suggested their usefulness as a distance indicator, but has not commented on their relationship as compared with other types of variable stars. In this work, we use Fourier analysis to quantify the structure of ULPC light curves and compare them to Classical Cepheids and Mira variables. Our preliminary results suggest that the low order Fourier parameters of ULPCs show a continuous trend defined by Classical Cepheids after the resonance around 10 days. However their Fourier parameters also overlapped with those from Miras, which make the classification of long period variable stars difficult based on the light curves information alone.

  19. Determinants of Trade Credit: A Preliminary Analysis on Construction Sector

    Directory of Open Access Journals (Sweden)

    Nicoleta Barbuta-Misu

    2016-07-01

    Full Text Available This paper introduces a preliminary analysis of the correlations between trade credit and some selected measures of financial performance for a sample of 958 firms acting in the construction sector. The examined period covers 2004-2013. The sample derived from Amadeus database contains firms that have sold and bought on credit. Results showed that larger firms offered and used more credit than counterparties. Firms offered and used in same time credit, but not in same level. Firms with higher return on assets and profit margin used and offered less credit from suppliers, respectively to clients. Moreover, more liquid firms used less trade payables.

  20. Dynamic Resonance Sensitivity Analysis in Wind Farms

    DEFF Research Database (Denmark)

    Ebrahimzadeh, Esmaeil; Blaabjerg, Frede; Wang, Xiongfei

    2017-01-01

    Unlike conventional power systems, where resonance frequencies are mainly determined by passive impedances, wind farms present a more complex situation, where the control systems of the power electronic converters introduce also active impedances. This paper presents an approach to find the reson......Unlike conventional power systems, where resonance frequencies are mainly determined by passive impedances, wind farms present a more complex situation, where the control systems of the power electronic converters introduce also active impedances. This paper presents an approach to find...... (PFs) are calculated by critical eigenvalue sensitivity analysis versus the entries of the MIMO matrix. The PF analysis locates the most exciting bus of the resonances, where can be the best location to install the passive or active filters to reduce the harmonic resonance problems. Time...

  1. CONTENT ANALYSIS, DISCOURSE ANALYSIS, AND CONVERSATION ANALYSIS: PRELIMINARY STUDY ON CONCEPTUAL AND THEORETICAL METHODOLOGICAL DIFFERENCES

    Directory of Open Access Journals (Sweden)

    Anderson Tiago Peixoto Gonçalves

    2016-08-01

    Full Text Available This theoretical essay aims to reflect on three models of text interpretation used in qualitative research, which is often confused in its concepts and methodologies (Content Analysis, Discourse Analysis, and Conversation Analysis. After the presentation of the concepts, the essay proposes a preliminary discussion on conceptual and theoretical methodological differences perceived between them. A review of the literature was performed to support the conceptual and theoretical methodological discussion. It could be verified that the models have differences related to the type of strategy used in the treatment of texts, the type of approach, and the appropriate theoretical position.

  2. Enhanced Accident Tolerant Fuels for LWRS - A Preliminary Systems Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gilles Youinou; R. Sonat Sen

    2013-09-01

    The severe accident at Fukushima Daiichi nuclear plants illustrates the need for continuous improvements through developing and implementing technologies that contribute to safe, reliable and cost-effective operation of the nuclear fleet. Development of enhanced accident tolerant fuel contributes to this effort. These fuels, in comparison with the standard zircaloy – UO2 system currently used by the LWR industry, should be designed such that they tolerate loss of active cooling in the core for a longer time period (depending on the LWR system and accident scenario) while maintaining or improving the fuel performance during normal operations, operational transients, and design-basis events. This report presents a preliminary systems analysis related to most of these concepts. The potential impacts of these innovative LWR fuels on the front-end of the fuel cycle, on the reactor operation and on the back-end of the fuel cycle are succinctly described without having the pretension of being exhaustive. Since the design of these various concepts is still a work in progress, this analysis can only be preliminary and could be updated as the designs converge on their respective final version.

  3. Electronic Warfare M-on-N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis

    Science.gov (United States)

    2017-04-12

    E. Jarvis Electronic Warfare M-on- N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis Advanced Techniques Branch Tactical...12-04-2017 NRL Memorandum Report Electronic Warfare M-on- N Digital Simulation Logging Requirements and HDF5: A Preliminary Analysis Donald E...ELECTRONIC WARFARE M-ON- N DIGITAL SIMULATION LOGGING REQUIREMENTS AND HDF5: A PRELIMINARY ANALYSIS 1. INTRODUCTION HDF5 technology [Folk] has been

  4. A Sensitivity Analysis of SOLPS Plasma Detachment

    Science.gov (United States)

    Green, D. L.; Canik, J. M.; Eldon, D.; Meneghini, O.; AToM SciDAC Collaboration

    2016-10-01

    Predicting the scrape off layer plasma conditions required for the ITER plasma to achieve detachment is an important issue when considering divertor heat load management options that are compatible with desired core plasma operational scenarios. Given the complexity of the scrape off layer, such predictions often rely on an integrated model of plasma transport with many free parameters. However, the sensitivity of any given prediction to the choices made by the modeler is often overlooked due to the logistical difficulties in completing such a study. Here we utilize an OMFIT workflow to enable a sensitivity analysis of the midplane density at which detachment occurs within the SOLPS model. The workflow leverages the TaskFarmer technology developed at NERSC to launch many instances of the SOLPS integrated model in parallel to probe the high dimensional parameter space of SOLPS inputs. We examine both predictive and interpretive models where the plasma diffusion coefficients are chosen to match an empirical scaling for divertor heat flux width or experimental profiles respectively. This research used resources of the National Energy Research Scientific Computing Center, a DOE Office of Science User Facility, and is supported under Contracts DE-AC02-05CH11231, DE-AC05-00OR22725 and DE-SC0012656.

  5. Synthesis, Characterization, and Sensitivity Analysis of Urea Nitrate (UN)

    Science.gov (United States)

    2015-04-01

    ARL-TR-7250 ● APR 2015 US Army Research Laboratory Synthesis, Characterization, and Sensitivity Analysis of Urea Nitrate (UN...Characterization, and Sensitivity Analysis of Urea Nitrate (UN) by William M Sherrill Weapons and Materials Research Directorate...Characterization, and Sensitivity Analysis of Urea Nitrate (UN) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

  6. Scalable analysis tools for sensitivity analysis and UQ (3160) results.

    Energy Technology Data Exchange (ETDEWEB)

    Karelitz, David B.; Ice, Lisa G.; Thompson, David C.; Bennett, Janine C.; Fabian, Nathan; Scott, W. Alan; Moreland, Kenneth D.

    2009-09-01

    The 9/30/2009 ASC Level 2 Scalable Analysis Tools for Sensitivity Analysis and UQ (Milestone 3160) contains feature recognition capability required by the user community for certain verification and validation tasks focused around sensitivity analysis and uncertainty quantification (UQ). These feature recognition capabilities include crater detection, characterization, and analysis from CTH simulation data; the ability to call fragment and crater identification code from within a CTH simulation; and the ability to output fragments in a geometric format that includes data values over the fragments. The feature recognition capabilities were tested extensively on sample and actual simulations. In addition, a number of stretch criteria were met including the ability to visualize CTH tracer particles and the ability to visualize output from within an S3D simulation.

  7. Sensitivity analysis of periodic matrix population models.

    Science.gov (United States)

    Caswell, Hal; Shyu, Esther

    2012-12-01

    Periodic matrix models are frequently used to describe cyclic temporal variation (seasonal or interannual) and to account for the operation of multiple processes (e.g., demography and dispersal) within a single projection interval. In either case, the models take the form of periodic matrix products. The perturbation analysis of periodic models must trace the effects of parameter changes, at each phase of the cycle, on output variables that are calculated over the entire cycle. Here, we apply matrix calculus to obtain the sensitivity and elasticity of scalar-, vector-, or matrix-valued output variables. We apply the method to linear models for periodic environments (including seasonal harvest models), to vec-permutation models in which individuals are classified by multiple criteria, and to nonlinear models including both immediate and delayed density dependence. The results can be used to evaluate management strategies and to study selection gradients in periodic environments.

  8. Preliminary hazards analysis of thermal scrap stabilization system. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, W.S.

    1994-08-23

    This preliminary analysis examined the HA-21I glovebox and its supporting systems for potential process hazards. Upon further analysis, the thermal stabilization system has been installed in gloveboxes HC-21A and HC-21C. The use of HC-21C and HC-21A simplified the initial safety analysis. In addition, these gloveboxes were cleaner and required less modification for operation than glovebox HA-21I. While this document refers to glovebox HA-21I for the hazards analysis performed, glovebox HC-21C is sufficiently similar that the following analysis is also valid for HC-21C. This hazards analysis document is being re-released as revision 1 to include the updated flowsheet document (Appendix C) and the updated design basis (Appendix D). The revised Process Flow Schematic has also been included (Appendix E). This Current revision incorporates the recommendations provided from the original hazards analysis as well. The System Design Description (SDD) has also been appended (Appendix H) to document the bases for Safety Classification of thermal stabilization equipment.

  9. Analysis preliminary phytochemical raw extract of leaves Nephrolepis pectinata

    Directory of Open Access Journals (Sweden)

    Natally Marreiros Gomes

    2017-06-01

    Full Text Available The Nephrolepis pectinata popularly known as paulista fern, ladder-heaven, cat tail, belongs to the family Davalliaceae. For the beauty of the arrangements of their leaves ferns are quite commercialized in Brazil, however, have not been described in the literature studies on their pharmacological potential. Thus, the objective of this research was to analyze the phytochemical properties of the crude extract of the leaves of Nephrolepis pectinata. To perform the phytochemical analysis were initially made the collection of the vegetable, preparation of voucher specimen, washing, drying and grinding. Then, extraction by percolation method and end the phytochemical analysis. Preliminary results phytochemicals the crude extract of the leaves of Nephrolepis pectinata tested positive for reducing sugars, phenols/tannins (catechins tannins and catechins.

  10. Sensitivity analysis of distributed volcanic source inversion

    Science.gov (United States)

    Cannavo', Flavio; Camacho, Antonio G.; González, Pablo J.; Puglisi, Giuseppe; Fernández, José

    2016-04-01

    A recently proposed algorithm (Camacho et al., 2011) claims to rapidly estimate magmatic sources from surface geodetic data without any a priori assumption about source geometry. The algorithm takes the advantages of fast calculation from the analytical models and adds the capability to model free-shape distributed sources. Assuming homogenous elastic conditions, the approach can determine general geometrical configurations of pressured and/or density source and/or sliding structures corresponding to prescribed values of anomalous density, pressure and slip. These source bodies are described as aggregation of elemental point sources for pressure, density and slip, and they fit the whole data (keeping some 3D regularity conditions). Although some examples and applications have been already presented to demonstrate the ability of the algorithm in reconstructing a magma pressure source (e.g. Camacho et al., 2011,Cannavò et al., 2015), a systematic analysis of sensitivity and reliability of the algorithm is still lacking. In this explorative work we present results from a large statistical test designed to evaluate the advantages and limitations of the methodology by assessing its sensitivity to the free and constrained parameters involved in inversions. In particular, besides the source parameters, we focused on the ground deformation network topology, and noise in measurements. The proposed analysis can be used for a better interpretation of the algorithm results in real-case applications. Camacho, A. G., González, P. J., Fernández, J. & Berrino, G. (2011) Simultaneous inversion of surface deformation and gravity changes by means of extended bodies with a free geometry: Application to deforming calderas. J. Geophys. Res. 116. Cannavò F., Camacho A.G., González P.J., Mattia M., Puglisi G., Fernández J. (2015) Real Time Tracking of Magmatic Intrusions by means of Ground Deformation Modeling during Volcanic Crises, Scientific Reports, 5 (10970) doi:10.1038/srep

  11. Preliminary Structural Sensitivity Study of Hypersonic Inflatable Aerodynamic Decelerator Using Probabilistic Methods

    Science.gov (United States)

    Lyle, Karen H.

    2014-01-01

    Acceptance of new spacecraft structural architectures and concepts requires validated design methods to minimize the expense involved with technology validation via flighttesting. This paper explores the implementation of probabilistic methods in the sensitivity analysis of the structural response of a Hypersonic Inflatable Aerodynamic Decelerator (HIAD). HIAD architectures are attractive for spacecraft deceleration because they are lightweight, store compactly, and utilize the atmosphere to decelerate a spacecraft during re-entry. However, designers are hesitant to include these inflatable approaches for large payloads or spacecraft because of the lack of flight validation. In the example presented here, the structural parameters of an existing HIAD model have been varied to illustrate the design approach utilizing uncertainty-based methods. Surrogate models have been used to reduce computational expense several orders of magnitude. The suitability of the design is based on assessing variation in the resulting cone angle. The acceptable cone angle variation would rely on the aerodynamic requirements.

  12. Longitudinal Genetic Analysis of Anxiety Sensitivity

    Science.gov (United States)

    Zavos, Helena M. S.; Gregory, Alice M.; Eley, Thalia C.

    2012-01-01

    Anxiety sensitivity is associated with both anxiety and depression and has been shown to be heritable. Little, however, is known about the role of genetic influence on continuity and change of symptoms over time. The authors' aim was to examine the stability of anxiety sensitivity during adolescence. By using a genetically sensitive design, the…

  13. SENSITIVE ERROR ANALYSIS OF CHAOS SYNCHRONIZATION

    Institute of Scientific and Technical Information of China (English)

    HUANG XIAN-GAO; XU JIAN-XUE; HUANG WEI; L(U) ZE-JUN

    2001-01-01

    We study the synchronizing sensitive errors of chaotic systems for adding other signals to the synchronizing signal.Based on the model of the Henon map masking, we examine the cause of the sensitive errors of chaos synchronization.The modulation ratio and the mean square error are defined to measure the synchronizing sensitive errors by quality.Numerical simulation results of the synchronizing sensitive errors are given for masking direct current, sinusoidal and speech signals, separately. Finally, we give the mean square error curves of chaos synchronizing sensitivity and threedimensional phase plots of the drive system and the response system for masking the three kinds of signals.

  14. Solar Stirling power generation - Systems analysis and preliminary tests

    Science.gov (United States)

    Selcuk, M. K.; Wu, Y.-C.; Moynihan, P. I.; Day, F. D., III

    1977-01-01

    The feasibility of an electric power generation system utilizing a sun-tracking parabolic concentrator and a Stirling engine/linear alternator is being evaluated. Performance predictions and cost analysis of a proposed large distributed system are discussed. Design details and preliminary test results are presented for a 9.5 ft diameter parabolic dish at the Jet Propulsion Laboratory (Caltech) Table Mountain Test Facility. Low temperature calorimetric measurements were conducted to evaluate the concentrator performance, and a helium flow system is being used to test the solar receiver at anticipated working fluid temperatures (up to 650 or 1200 C) to evaluate the receiver thermal performance. The receiver body is designed to adapt to a free-piston Stirling engine which powers a linear alternator assembly for direct electric power generation. During the next phase of the program, experiments with an engine and receiver integrated into the concentrator assembly are planned.

  15. Primate phylogeny studied by comparative determinant analysis. A preliminary report.

    Science.gov (United States)

    Bauer, K

    1993-01-01

    In this preliminary report the divergence times for the major primate groups are given, calculated from a study by comparative determinant analysis of 69 proteins (equaling 0.1% of the whole genetic information). With an origin of the primate order set at 80 million years before present, the ages of the last common ancestors (LCAs) of man and the major primate groups obtained this way are as follows: Pan troglodytes 5.2; Gorilla gorilla 7.4; Pongo pygmaeus 19.2; Hylobates lar 20.3; Old World monkeys 31.4; Lagothrix lagotricha 46.0; Cebus albifrons 59.5; three lemur species 67.0, and Galago crassicaudatus 73.3 million years. The LCA results and the approach are shortly discussed. A full account of this extended investigation including results on nonprimate mammals and on the determinant structures and the immunologically derived evolutionary rates of the proteins analyzed will be published elsewhere.

  16. PRELIMINARY PHYTOCHEMICAL ANALYSIS OF ACTINIOPTERIS RADIATA (SWARTZ LINK.

    Directory of Open Access Journals (Sweden)

    R. Manonmani

    2013-06-01

    Full Text Available The objective of the present study was to find out the presence of preliminary phytochemicals in six different solvent extracts of Actiniopteris radiata (Swartz link. by qualitative screening methods. The solvent used for the extraction of leaf and rhizome powder were ethanol, petroleum ether, chloroform, acetone, DMSO and aqueous. The secondary metabolites such as steroids, triterpenoids, reducing sugars, sugars, alkaloids, phenolic compounds, catechins, flavonoids, saponins, tannins, anthroquinones and amino acids were screened by using standard methods. The phytochemical analysis of the ethanolic extract of both (leaf & rhizome revealed the presence of most active constituents than the other solvents. The ethanolic rhizome extracts of Actiniopteris radiata showed higher amount of phytochemicals when compared with the ethanolic leaf extracts.

  17. Visualization of periventricular collaterals in moyamoya disease with flow-sensitive black-blood magnetic resonance angiography: preliminary experience.

    Science.gov (United States)

    Funaki, Takeshi; Fushimi, Yasutaka; Takahashi, Jun C; Takagi, Yasushi; Araki, Yoshio; Yoshida, Kazumichi; Kikuchi, Takayuki; Miyamoto, Susumu

    2015-01-01

    Fragile abnormal collaterals in moyamoya disease, known as "moyamoya vessels," have rarely been defined. While flow-sensitive black-blood magnetic resonance angiography (FSBB-MRA) is a promising technique for visualizing perforating arteries, as of this writing no other reports exist regarding its application to moyamoya disease. Six adults with moyamoya disease underwent FSBB-MRA. It depicted abnormal collaterals as extended lenticulostriate, thalamic perforating, or choroidal arteries, which were all connected to the medullary or insular artery in the periventricular area and supplied the cortex. This preliminary case series illustrates the potential for FSBB-MRA to reveal abnormal moyamoya vessels, which could be reasonably defined as periventricular collaterals.

  18. CUSUM control charts based on likelihood ratio for preliminary analysis

    Institute of Scientific and Technical Information of China (English)

    Yi DAI; Zhao-jun WANG; Chang-liang ZOU

    2007-01-01

    To detect and estimate a shift in either the mean and the deviation or both for the preliminary analysis, the statistical process control (SPC) tool, the control chart based on the likelihood ratio test (LRT), is the most popular method.Sullivan and woodall pointed out the test statistic lrt (n1, n2) is approximately distributed as x2 (2) as the sample size n, n1 and n2 are very large, and the value of n1 = 2, 3,..., n- 2 and that of n2 = n- n1.So it is inevitable that n1 or n2 is not large. In this paper the limit distribution of lrt(n1, n2) for fixed n1 or n2 is figured out, and the exactly analytic formulae for evaluating the expectation and the variance of the limit distribution are also obtained.In addition, the properties of the standardized likelihood ratio statistic slr(n1,n) are discussed in this paper. Although slr(n1, n) contains the most important information, slr(i, n)(i ≠ n1) also contains lots of information. The cumulative sum (CUSUM) control chart can obtain more information in this condition. So we propose two CUSUM control charts based on the likelihood ratio statistics for the preliminary analysis on the individual observations. One focuses on detecting the shifts in location in the historical data and the other is more general in detecting a shift in either the location and the scale or both.Moreover, the simulated results show that the proposed two control charts are, respectively, superior to their competitors not only in the detection of the sustained shifts but also in the detection of some other out-of-control situations considered in this paper.

  19. CUSUM control charts based on likelihood ratio for preliminary analysis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    To detect and estimate a shift in either the mean and the deviation or both for the preliminary analysis, the statistical process control (SPC) tool, the control chart based on the likelihood ratio test (LRT), is the most popular method. Sullivan and woodall pointed out the test statistic lrt(n1, n2) is approximately distributed as x2(2) as the sample size n,n1 and n2 are very large, and the value of n1 = 2,3,..., n - 2 and that of n2 = n - n1. So it is inevitable that n1 or n2 is not large. In this paper the limit distribution of lrt(n1, n2) for fixed n1 or n2 is figured out, and the exactly analytic formulae for evaluating the expectation and the variance of the limit distribution are also obtained. In addition, the properties of the standardized likelihood ratio statistic slr(n1, n) are discussed in this paper. Although slr(n1, n) contains the most important information, slr(i, n)(i≠n1) also contains lots of information. The cumulative sum (CUSUM) control chart can obtain more information in this condition. So we propose two CUSUM control charts based on the likelihood ratio statistics for the preliminary analysis on the individual observations. One focuses on detecting the shifts in location in the historical data and the other is more general in detecting a shift in either the location and the scale or both. Moreover, the simulated results show that the proposed two control charts are, respectively, superior to their competitors not only in the detection of the sustained shifts but also in the detection of some other out-of-control situations considered in this paper.

  20. Sensitivity analysis of retrovirus HTLV-1 transactivation.

    Science.gov (United States)

    Corradin, Alberto; Di Camillo, Barbara; Ciminale, Vincenzo; Toffolo, Gianna; Cobelli, Claudio

    2011-02-01

    Human T-cell leukemia virus type 1 is a human retrovirus endemic in many areas of the world. Although many studies indicated a key role of the viral protein Tax in the control of viral transcription, the mechanisms controlling HTLV-1 expression and its persistence in vivo are still poorly understood. To assess Tax effects on viral kinetics, we developed a HTLV-1 model. Two parameters that capture both its deterministic and stochastic behavior were quantified: Tax signal-to-noise ratio (SNR), which measures the effect of stochastic phenomena on Tax expression as the ratio between the protein steady-state level and the variance of the noise causing fluctuations around this value; t(1/2), a parameter representative of the duration of Tax transient expression pulses, that is, of Tax bursts due to stochastic phenomena. Sensitivity analysis indicates that the major determinant of Tax SNR is the transactivation constant, the system parameter weighting the enhancement of retrovirus transcription due to transactivation. In contrast, t(1/2) is strongly influenced by the degradation rate of the mRNA. In addition to shedding light into the mechanism of Tax transactivation, the obtained results are of potential interest for novel drug development strategies since the two parameters most affecting Tax transactivation can be experimentally tuned, e.g. by perturbing protein phosphorylation and by RNA interference.

  1. Supercritical extraction of oleaginous: parametric sensitivity analysis

    Directory of Open Access Journals (Sweden)

    Santos M.M.

    2000-01-01

    Full Text Available The economy has become universal and competitive, thus the industries of vegetable oil extraction must advance in the sense of minimising production costs and, at the same time, generating products that obey more rigorous patterns of quality, including solutions that do not damage the environment. The conventional oilseed processing uses hexane as solvent. However, this solvent is toxic and highly flammable. Thus the search of substitutes for hexane in oleaginous extraction process has increased in the last years. The supercritical carbon dioxide is a potential substitute for hexane, but it is necessary more detailed studies to understand the phenomena taking place in such process. Thus, in this work a diffusive model for semi-continuous (batch for the solids and continuous for the solvent isothermal and isobaric extraction process using supercritical carbon dioxide is presented and submitted to a parametric sensitivity analysis by means of a factorial design in two levels. The model parameters were disturbed and their main effects analysed, so that it is possible to propose strategies for high performance operation.

  2. An addendum on sensitivity analysis of the optimal assignment

    NARCIS (Netherlands)

    Volgenant, A.

    2006-01-01

    We point out that sensitivity results for the linear assignment problem can be produced by a shortest path based approach in a straightforward manner and as efficient as finding an optimal solution. Keywords: Assignment; Sensitivity analysis

  3. Sensitivity Analysis of FEAST-Metal Fuel Performance Code: Initial Results

    Energy Technology Data Exchange (ETDEWEB)

    Edelmann, Paul Guy [Los Alamos National Laboratory; Williams, Brian J. [Los Alamos National Laboratory; Unal, Cetin [Los Alamos National Laboratory; Yacout, Abdellatif [Argonne National Laboratories

    2012-06-27

    This memo documents the completion of the LANL milestone, M3FT-12LA0202041, describing methodologies and initial results using FEAST-Metal. The FEAST-Metal code calculations for this work are being conducted at LANL in support of on-going activities related to sensitivity analysis of fuel performance codes. The objective is to identify important macroscopic parameters of interest to modeling and simulation of metallic fuel performance. This report summarizes our preliminary results for the sensitivity analysis using 6 calibration datasets for metallic fuel developed at ANL for EBR-II experiments. Sensitivity ranking methodology was deployed to narrow down the selected parameters for the current study. There are approximately 84 calibration parameters in the FEAST-Metal code, of which 32 were ultimately used in Phase II of this study. Preliminary results of this sensitivity analysis led to the following ranking of FEAST models for future calibration and improvements: fuel conductivity, fission gas transport/release, fuel creep, and precipitation kinetics. More validation data is needed to validate calibrated parameter distributions for future uncertainty quantification studies with FEAST-Metal. Results of this study also served to point out some code deficiencies and possible errors, and these are being investigated in order to determine root causes and to improve upon the existing code models.

  4. Preliminary assessment of terrestrial microalgae isolated from lichens as testing species for environmental monitoring: lichen phycobionts present high sensitivity to environmental micropollutants.

    Science.gov (United States)

    Domínguez-Morueco, N; Moreno, H; Barreno, E; Catalá, M

    2014-01-01

    Bioassays constitute a tool for pollution analysis providing a holistic approach and high-quality indication of the toxicity. Microbioassays allow evaluating the toxicity of many samples, implying lower costs and enabling routine monitoring and pollution control. But tests conducted so far are limited to the use of a small number of taxa. Lichens are excellent bioindicators of pollution with great ecological significance. Studies show that the phycobiont is more sensitive to pollutants than the mycobiont. Phycobiont have features such as adaptation to anhydrobiosis and relatively rapid growth in vitro, making them suitable for microbioassays. Our aim is to determine the sensitivity of phycobionts to the pharmaceutical micropollutants carbamazepine and diclofenac as a preliminary step for the development of a toxicity microbioassay based on phycobionts. Optical dispersion and chlorophyll autofluorescence were used as endpoints of toxicity on two algal species showing that suspensions present cyclic and taxon specific patterns of aggregation. Trebouxia TR9 suspensions present a very high grade of aggregation while Asterochloris erici cells do not. Both micropollutants alter optical properties of the suspensions of both species. No significant alteration of chlorophyll autofluorescence by carbamazepine is observed. A. erici chlorophyll autofluorescence is extremely sensitive to diclofenac but the effect is not dependent on the drug concentration or on the time of exposure. Differently, TR9 only shows punctual chlorophyll alterations. Fluctuations in optical dispersion may indicate changes in the population structure of the species, including reproductive strategy. A. erici seems more sensitive to micropollutants, is better characterized and is available from commercial collections.

  5. Harvested power and sensitivity analysis of vibrating shoe-mounted piezoelectric cantilevers

    Science.gov (United States)

    Moro, L.; Benasciutti, D.

    2010-11-01

    This paper presents a preliminary investigation on energy harvesting from human walking via piezoelectric vibrating cantilevers. Heel accelerations during human gait are established by correlating data gathered from the literature with direct experimental measurements. All the observed relevant features are synthesized in a typical (standard) acceleration signal, used in subsequent numerical simulations. The transient electromechanical response and the harvested power of a shoe-mounted bimorph cantilever excited by the standard acceleration signal is computed by numerical simulations and compared with measurements on a real prototype. A sensitivity analysis is finally developed to estimate the mean harvested power for a wide range of scavenger configurations. Acceptability criteria based on imposed geometrical constraints and resistance strength limits (e.g. fatigue limit) are also established. This analysis allows a quick preliminary screening of harvesting performance of different scavenger configurations.

  6. Preliminary analysis of distributed in situ soil moisture measurements

    Directory of Open Access Journals (Sweden)

    L. Brocca

    2005-01-01

    Full Text Available Surface soil moisture content is highly variable in both space and time. Remote sensing can provide an effective methodology for mapping surface moisture content over large areas but ground based measurements are required to test its reliability and to calibrate retrieval algorithms. Recently, we had the opportunity to design and perform an experiment aimed at jointly acquiring measurements of surface soil water content at various locations and remotely sensed hyperspectral data. The area selected for the experiment is located in central Umbria and it extends for 90km2. For the area, detailed lithological and multi-temporal landslide inventory maps were available. We identified eight plots where measurements of soil water content were made using a Time Domain Reflectometer (TDR. The plots range in size from 100m2 to 600m2, and cover a variety of topographic and morphological settings. The TDR measurements were conducted during four days, on 5 April, 15 April, 2 May and 3 May 2004. On 3 May the NERC airborne CASI 2 acquired the hyperspectral data. Preliminary analysis concerning the matching between the landslides and the soil moisture were reported. Statistical and geostatistical analysis investigating the spatial-temporal soil moisture distribution were performed. These results will be compared with the data of surface temperature obtained from the remotely sensed hyperspectral sensor.

  7. Sensitivity of permanent meadows areas. Preliminary report; Sensibilite des zones de prairies permanentes. Rapport preliminaire

    Energy Technology Data Exchange (ETDEWEB)

    Pourcelot, L

    2006-07-01

    The objective of this work proposed in the framework of the S.E.N.S.I.B. project on the permanent meadows areas is to compare the sensitivity of these surfaces and cheese maker sector which are associated with them, and to identify the processes which determine this sensitivity. The realization of this objective will lean on certain data of activities acquired recently by the I.R.S.N. (compartments: soils, herb, milk and cheese), as well as on new measures, on three sites: Saint-Laurent-de-Geris ( West), Beaune-Le-Froid ( center), and Massif of Jura (East). Two scales of transfers observation and sensitivity are retained. In a first time, the sensitivity of meadows areas will studied at the regional scale, from data acquired in the Massif du Jura ( between 300 and 1200 metres up). In a second time, a study will allow to compare the sensitivity of three areas retained (West, Center, East) at the national scale. The expertise will be focused on the factors of sensitivity of the transfer soil-herb and the factors of sensitivity bound to the cheese makers sectors. The data of the already available zones of study create strong variabilities of the rates of {sup 137}Cs transfer in the interfaces soil / herb and herb / milk, letting suppose that the nature of soils, the quantity and the quality of food ingested by the cattle constitutes dominating factors of sensitivity. Besides, the size of the basin of milk collection, extremely variable from a site of study in the other one, has to influence the contamination of cheeses and as such, it establishes an important factor of sensitivity of the cheese makers sector. (N.C.)

  8. Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium.

    Science.gov (United States)

    Dontsova, Mariya V; Savochkina, Yulia A; Gabdoulkhakov, Azat G; Baidakov, Sergey N; Lyashenko, Andrey V; Zolotukhina, Maria; Errais Lopes, Liubov; Garber, Mariya B; Morgunova, Ekaterina Yu; Nikonov, Stanislav V; Mironov, Alexandr S; Ealick, Steven E; Mikhailov, Al 'Bert M

    2004-04-01

    The structural udp gene encoding uridine phosphorylase (UPh) was cloned from the Salmonella typhimurium chromosome and overexpressed in Escherichia coli cells. S. typhimurium UPh (StUPh) was purified to apparent homogeneity and crystallized. The primary structure of StUPh has high homology to the UPh from E. coli, but the enzymes differ substantially in substrate specificity and sensitivity to the polarity of the medium. Single crystals of StUPh were grown using hanging-drop vapor diffusion with PEG 8000 as the precipitant. X-ray diffraction data were collected to 2.9 A resolution. Preliminary analysis of the diffraction data indicated that the crystal belonged to space group P6(1(5)), with unit-cell parameters a = 92.3, c = 267.5 A. The solvent content is 37.7% assuming the presence of one StUPh hexamer per asymmetric unit.

  9. Preliminary evidence about the effects of meditation on interoceptive sensitivity and social cognition

    OpenAIRE

    Melloni, Margherita; Sedeño, Lucas; Couto, Juan Blas Marcos; Reynoso, Martín; Gelormini Lezama, Carlos; Favaloro, Roberto; Canales Johnson, Andres; Sigman, Mariano; Manes, Facundo Francisco; Ibañez, Agustín

    2015-01-01

    Background: Interoception refers to the conscious perception of body signals. Mindfulness is a meditation practice that encourages individuals to focus on their internal experiences such as bodily sensations, thoughts, and emotions. In this study, we selected a behavioral measure of interoceptive sensitivity (heartbeat detection task, HBD) to compare the effect of meditation practice on interoceptive sensitivity among long term practitioners (LTP), short term meditators (STM, subjects that co...

  10. A discourse on sensitivity analysis for discretely-modeled structures

    Science.gov (United States)

    Adelman, Howard M.; Haftka, Raphael T.

    1991-01-01

    A descriptive review is presented of the most recent methods for performing sensitivity analysis of the structural behavior of discretely-modeled systems. The methods are generally but not exclusively aimed at finite element modeled structures. Topics included are: selections of finite difference step sizes; special consideration for finite difference sensitivity of iteratively-solved response problems; first and second derivatives of static structural response; sensitivity of stresses; nonlinear static response sensitivity; eigenvalue and eigenvector sensitivities for both distinct and repeated eigenvalues; and sensitivity of transient response for both linear and nonlinear structural response.

  11. Grid-connected ICES: preliminary feasibility analysis and evaluation. Volume 2. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1977-06-30

    The HEAL Complex in New Orleans will serve as a Demonstration Community for which the ICES Demonstration System will be designed. The complex is a group of hospitals, clinics, research facilities, and medical educational facilities. The five tasks reported on are: preliminary energy analysis; preliminary institutional assessment; conceptual design; firming-up of commitments; and detailed work management plan.

  12. Purification, crystallization and preliminary X-ray analysis of struthiocalcin 1 from ostrich (Struthio camelus) eggshell

    Energy Technology Data Exchange (ETDEWEB)

    Reyes-Grajeda, Juan Pablo [Unidad de Proteómica Médica, Instituto Nacional de Medicina Genómica, Mexico City (Mexico); Marín-García, Liliana [Instituto de Química, Universidad Nacional Autónoma de México (Mexico); Stojanoff, Vivian [Brookhaven National Laboratories, NSLS, Upton, New York (United States); Moreno, Abel, E-mail: carcamo@servidor.unam.mx [Instituto de Química, Universidad Nacional Autónoma de México (Mexico); Unidad de Proteómica Médica, Instituto Nacional de Medicina Genómica, Mexico City (Mexico)

    2007-11-01

    The purification, crystallization and preliminary X-ray diffraction data of the protein struthiocalcin 1 isolated from ostrich eggshell are reported. The purification, crystallization and preliminary X-ray analysis of struthiocalcin 1 (SCA-1), a protein obtained from the intramineral part of ostrich (Struthio camelus) eggshell, is reported.

  13. Investigation of Sorption and Diffusion Mechanisms, and Preliminary Economic Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Bhave, Ramesh R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jubin, Robert Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Spencer, Barry B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nair, Sankar [Georgia Inst. of Technology, Atlanta, GA (United States)

    2017-02-01

    This report describes the synthesis and evaluation of molecular sieve zeolite membranes to separate and concentrate tritiated water (HTO) from dilute HTO-bearing aqueous streams. Several monovalent and divalent cation exchanged silico alumino phosphate (SAPO-34) molecular sieve zeolite membranes were synthesized on disk supports and characterized with gas and vapor permeation measurements. The pervaporation process performance was evaluated for the separation and concentration of tritiated water. Experiments were performed using tritiated water feed solution containing tritium at the high end of the range (1 mCi/mL) anticipated in a nuclear fuel processing system that includes both acid and water streams recycling. The tritium concentration was about 0.1 ppm. The permeate was recovered under vacuum. The HTO/H2O selectivity and separation factor calculated from the measured tritium concentrations ranged from 0.99 to 1.23, and 0.83-0.98, respectively. Although the membrane performance for HTO separation was lower than expected, several encouraging observations including molecular sieving and high vapor permeance are reported. Additionally, several new approaches are proposed, such as tuning the sorption and diffusion properties offered by small pore LTA zeolite materials, and cation exchanged aluminosilicates with high metal loading. It is hypothesized that substantially improved preferential transport of tritium (HTO) resulting in a more concentrated permeate can be achieved. Preliminary economic analysis for the membrane-based process to concentrate tritiated water is also discussed.

  14. Crystallization and preliminary crystallographic analysis of recombinant human galectin-1

    Energy Technology Data Exchange (ETDEWEB)

    Scott, Stacy A. [Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222 (Australia); Scott, Ken [School of Biological Sciences, University of Auckland, Auckland (New Zealand); Blanchard, Helen, E-mail: h.blanchard@griffith.edu.au [Institute for Glycomics, Gold Coast Campus, Griffith University, Queensland 4222 (Australia)

    2007-11-01

    Human galectin-1 has been cloned, expressed in E. coli, purified and crystallized in the presence of both lactose (ligand) and β-mercaptoethanol under six different conditions. The X-ray diffraction data obtained have enabled the assignment of unit-cell parameters for two novel crystal forms of human galectin-1. Galectin-1 is considered to be a regulator protein as it is ubiquitously expressed throughout the adult body and is responsible for a broad range of cellular regulatory functions. Interest in galectin-1 from a drug-design perspective is founded on evidence of its overexpression by many cancers and its immunomodulatory properties. The development of galectin-1-specific inhibitors is a rational approach to the fight against cancer because although galectin-1 induces a plethora of effects, null mice appear normal. X-ray crystallographic structure determination will aid the structure-based design of galectin-1 inhibitors. Here, the crystallization and preliminary diffraction analysis of human galectin-1 crystals generated under six different conditions is reported. X-ray diffraction data enabled the assignment of unit-cell parameters for crystals grown under two conditions, one belongs to a tetragonal crystal system and the other was determined as monoclinic P2{sub 1}, representing two new crystal forms of human galectin-1.

  15. Preliminary radiation criteria and nuclear analysis for ETF

    Energy Technology Data Exchange (ETDEWEB)

    Engholm, B.A.

    1980-09-01

    Preliminary biological and materials radiation dose criteria for the Engineering Test Facility are described and tabulated. In keeping with the ETF Mission Statement, a key biological dose criterion is a 24-hour shutdown dose rate of 2 mrem/hr on the surface of the outboard bulk shield. Materials dose criteria, which primarily govern the inboard shield design, include 10/sup 9/ rads exposure limit to epoxy insulation, 3 x 10/sup -4/ dpa damage to the TF coil copper stabilizer, and a total nuclear heating rate of 5 kW in the inboard TF coils. Nuclear analysis performed during FY 80 was directed primarily at the inboard and outboard bulk shielding, and at radiation streaming in the neutral beam drift ducts. Inboard and outboard shield thicknesses to achieve the biological and materials radiation criteria are 75 cm inboard and 125 cm outboard, the configuration consisting of alternating layers of stainless steel and borated water. The outboard shield also includes a 5 cm layer of lead. NBI duct streaming analyses performed by ORNL and LASL will play a key role in the design of the duct and NBI shielding in FY 81. The NBI aluminum cryopanel nuclear heating rate during the heating cycle is about 1 milliwatt/cm/sup 3/, which is far less than the permissible limit.

  16. Preliminary analysis of aerial hyperspectral data on shallow lacustrine waters

    Science.gov (United States)

    Bianchi, Remo; Castagnoli, A.; Cavalli, Rosa M.; Marino, Carlo M.; Pignatti, Stefano; Zilioli, Eugenio

    1995-11-01

    The availability of MIVIS hyperspectral data, deriving from an aerial survey recently performed over a test-site in Lake Garda, Italy, gave the possibility of a preliminary new insight in the field of specific applications of remote sensing to shallow water analysis. The spectroradiometers in the visible and in the thermal infrared were explored in particular, accessing to helpful information for the detection of bio-physical indicators of water quality, either related to the surface/sub-surface of waters or to the bottom of the lake, since the study area presents very shallow waters, never exceeding a 6-meter depth in any case. Primary interest was the detection of man-induced activities along the margins, like sewage effect and sedimentary structure in the bottom or algal bloom. Secondly, a correlation between absorbivity coefficients in the visible bands and bathimetric contour lines in the proximity of the marginal zone of the lake was accomplished, by means of two indicative spectroradiometric transects.

  17. Implementation of efficient sensitivity analysis for optimization of large structures

    Science.gov (United States)

    Umaretiya, J. R.; Kamil, H.

    1990-01-01

    The paper presents the theoretical bases and implementation techniques of sensitivity analyses for efficient structural optimization of large structures, based on finite element static and dynamic analysis methods. The sensitivity analyses have been implemented in conjunction with two methods for optimization, namely, the Mathematical Programming and Optimality Criteria methods. The paper discusses the implementation of the sensitivity analysis method into our in-house software package, AutoDesign.

  18. Conversion Preliminary Safety Analysis Report for the NIST Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, D. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Baek, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hanson, A. L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cheng, L-Y [Brookhaven National Lab. (BNL), Upton, NY (United States); Brown, N. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cuadra, A. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-01-30

    The NIST Center for Neutron Research (NCNR) is a reactor-laboratory complex providing the National Institute of Standards and Technology (NIST) and the nation with a world-class facility for the performance of neutron-based research. The heart of this facility is the NIST research reactor (aka NBSR); a heavy water moderated and cooled reactor operating at 20 MW. It is fueled with high-enriched uranium (HEU) fuel elements. A Global Threat Reduction Initiative (GTRI) program is underway to convert the reactor to low-enriched uranium (LEU) fuel. This program includes the qualification of the proposed fuel, uranium and molybdenum alloy foil clad in an aluminum alloy, and the development of the fabrication techniques. This report is a preliminary version of the Safety Analysis Report (SAR) that would be submitted to the U.S. Nuclear Regulatory Commission (NRC) for approval prior to conversion. The report follows the recommended format and content from the NRC codified in NUREG-1537, “Guidelines for Preparing and Reviewing Applications for the Licensing of Non-power Reactors,” Chapter 18, “Highly Enriched to Low-Enriched Uranium Conversions.” The emphasis in any conversion SAR is to explain the differences between the LEU and HEU cores and to show the acceptability of the new design; there is no need to repeat information regarding the current reactor that will not change upon conversion. Hence, as seen in the report, the bulk of the SAR is devoted to Chapter 4, Reactor Description, and Chapter 13, Safety Analysis.

  19. Narrative foreclosure in later life: Preliminary considerations for a new sensitizing concept

    NARCIS (Netherlands)

    Bohlmeijer, Ernst Thomas; Westerhof, Gerben Johan; Randall, W.; Tromp, T.; Kenyon, G.

    2011-01-01

    The objective of the paper is to explore narrative foreclosure as a sensitizing concept for studying the ways in which narrative identity development falters in later life. Two main characters in famous movies are contrasted to provide a better understanding of narrative foreclosure. The concept is

  20. Narrative foreclosure in later life: preliminary considerations for a new sensitizing concept

    NARCIS (Netherlands)

    Bohlmeijer, E.T.; Westerhof, G.J.; Randall, W.; Tromp, T.; Kenyon, G.

    2011-01-01

    The objective of the paper is to explore narrative foreclosure as a sensitizing concept for studying the ways in which narrative identity development falters in later life. Two main characters in famous movies are contrasted to provide a better understanding of narrative foreclosure. The concept is

  1. Preliminary Analysis of Remote Monitoring & Robotic Concepts for Performance Confirmation

    Energy Technology Data Exchange (ETDEWEB)

    D.A. McAffee

    1997-02-18

    ) Identify and discuss the main Performance Confirmation monitoring needs and requirements during the post-emplacement preclosure period. This includes radiological, non-radiological, host rock, and infrastructure performance monitoring needs. It also includes monitoring for possible off-normal events. (Presented in Section 7.3). (3) Identify general approaches and methods for obtaining performance information from within the emplacement drifts for Performance Confirmation. (Presented in Section 7.4) (4)Review and discuss available technologies and design strategies that may permit the use of remotely operated systems within the hostile thermal and radiation environment expected within the emplacement drifts. (Presented in Section 7.5). (5) Based on Performance Confirmation monitoring needs and available technologies, identify potential application areas for remote systems and robotics for post-emplacement preclosure Performance Confirmation activities (Presented in Section 7.6). (6) Develop preliminary remote monitoring and robotic concepts for post-emplacement, preclosure Performance Confirmation activities. (Presented in Section 7.7) This analysis is being performed very early in the systems engineering cycle, even as issues related to the Performance Confirmation program planning phase are being formulated and while the associated needs, constraints and objectives are yet to be fully determined and defined. This analysis is part of an issue formulation effort and is primarily concerned with identification and description of key issues related to remotely monitoring repository performance for Performance Confirmation. One of the purposes of this analysis is to provide an early investigation of potential design challenges that may have a high impact on future design concepts. This analysis can be used to guide future concept development and help access what is feasible and achievable by application of remote systems technology. Future design and systems engineering

  2. A Preliminary Tsunami vulnerability analysis for Bakirkoy district in Istanbul

    Science.gov (United States)

    Tufekci, Duygu; Lutfi Suzen, M.; Cevdet Yalciner, Ahmet; Zaytsev, Andrey

    2016-04-01

    Resilience of coastal utilities after earthquakes and tsunamis has major importance for efficient and proper rescue and recovery operations soon after the disasters. Vulnerability assessment of coastal areas under extreme events has major importance for preparedness and development of mitigation strategies. The Sea of Marmara has experienced numerous earthquakes as well as associated tsunamis. There are variety of coastal facilities such as ports, small craft harbors, and terminals for maritime transportation, water front roads and business centers mainly at North Coast of Marmara Sea in megacity Istanbul. A detailed vulnerability analysis for Yenikapi region and a detailed resilience analysis for Haydarpasa port in Istanbul have been studied in previously by Cankaya et al., (2015) and Aytore et al., (2015) in SATREPS project. In this study, the methodology of vulnerability analysis under tsunami attack given in Cankaya et al., (2015) is modified and applied to Bakirkoy district of Istanbul. Bakirkoy district is located at western part of Istanbul and faces to the North Coast of Marmara Sea from 28.77oE to 28.89oE. High resolution spatial dataset of Istanbul Metropolitan Municipality (IMM) is used and analyzed. The bathymetry and topography database and the spatial dataset containing all buildings/structures/infrastructures in the district are collated and utilized for tsunami numerical modeling and following vulnerability analysis. The tsunami parameters from deterministically defined worst case scenarios are computed from the simulations using tsunami numerical model NAMI DANCE. The vulnerability assessment parameters in the district according to vulnerability and resilience are defined; and scored by implementation of a GIS based TVA with appropriate MCDA methods. The risk level is computed using tsunami intensity (level of flow depth from simulations) and TVA results at every location in Bakirkoy district. The preliminary results are presented and discussed

  3. Sensitivity Analysis of Situational Awareness Measures

    Science.gov (United States)

    Shively, R. J.; Davison, H. J.; Burdick, M. D.; Rutkowski, Michael (Technical Monitor)

    2000-01-01

    A great deal of effort has been invested in attempts to define situational awareness, and subsequently to measure this construct. However, relatively less work has focused on the sensitivity of these measures to manipulations that affect the SA of the pilot. This investigation was designed to manipulate SA and examine the sensitivity of commonly used measures of SA. In this experiment, we tested the most commonly accepted measures of SA: SAGAT, objective performance measures, and SART, against different levels of SA manipulation to determine the sensitivity of such measures in the rotorcraft flight environment. SAGAT is a measure in which the simulation blanks in the middle of a trial and the pilot is asked specific, situation-relevant questions about the state of the aircraft or the objective of a particular maneuver. In this experiment, after the pilot responded verbally to several questions, the trial continued from the point frozen. SART is a post-trial questionnaire that asked for subjective SA ratings from the pilot at certain points in the previous flight. The objective performance measures included: contacts with hazards (power lines and towers) that impeded the flight path, lateral and vertical anticipation of these hazards, response time to detection of other air traffic, and response time until an aberrant fuel gauge was detected. An SA manipulation of the flight environment was chosen that undisputedly affects a pilot's SA-- visibility. Four variations of weather conditions (clear, light rain, haze, and fog) resulted in a different level of visibility for each trial. Pilot SA was measured by either SAGAT or the objective performance measures within each level of visibility. This enabled us to not only determine the sensitivity within a measure, but also between the measures. The SART questionnaire and the NASA-TLX, a measure of workload, were distributed after every trial. Using the newly developed rotorcraft part-task laboratory (RPTL) at NASA Ames

  4. Sensitivity analysis of soil parameters based on interval

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Interval analysis is a new uncertainty analysis method for engineering struc-tures. In this paper, a new sensitivity analysis method is presented by introducing interval analysis which can expand applications of the interval analysis method. The interval anal-ysis process of sensitivity factor matrix of soil parameters is given. A method of parameter intervals and decision-making target intervals is given according to the interval analysis method. With FEM, secondary developments are done for Marc and the Duncan-Chang nonlinear elastic model. Mutual transfer between FORTRAN and Marc is implemented. With practial examples, rationality and feasibility are validated. Comparison is made with some published results.

  5. Hair dye dermatitis and p-phenylenediamine contact sensitivity: A preliminary report

    Directory of Open Access Journals (Sweden)

    Mrinal Gupta

    2015-01-01

    Full Text Available Background: The contact allergic reactions from p-phenylenediamine (PPD in hair dyes vary from mild contact dermatitis to severe life- threatening events (angioedema, bronchospasm, asthma, renal impairment. Objectives: To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis. Materials and Methods: Eighty (M: F 47:33 consecutive patients aged between 18 and 74 years suspected to have contact allergy from hair dye were studied by patch testing with Indian Standard Series including p-phenylenediamine (PPD, 1.0% pet. Results: 54 Fifty-four (M: F 21:33 patients showed positive patch tests from PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix, paraben mix, or colophony. Fifty-seven (71% patients affected were aged older than 40 years. The duration of dermatitis varied from 1 year with exacerbation following hair coloring. Forty-nine patients had dermatitis of scalp and/or scalp margins and 23 patients had face and neck dermatitis. Periorbital dermatitis, chronic actinic dermatitis, and erythema multiforme-like lesions were seen in 4, 2, and 1 patients, respectively. Conclusions: Hair dyes and PPD constitute a significant cause of contact dermatitis. There is an urgent need for creating consumer awareness regarding hair-dyes contact sensitivity and the significance of performing sensitivity testing prior to actual use.

  6. Preliminary Core Analysis of a Micro Modular Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Chang Keun; Chang, Jongwa [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Venneri, Francesco [Ultra Safe Nuclear Corporation, Los Alamos (United States); Hawari, Ayman [NC State Univ., Raleigh (United States)

    2014-05-15

    The Micro Modular Reactor (MMR) will be 'melt-down proof'(MDP) under all circumstances, including the complete loss of coolant, and will be easily transportable and retrievable, and suitable for use with very little site preparation and Balance of Plant (BOP) requirements for a variety of applications, from power generation and process heat applications in remote areas to grid-unattached locations, including ship propulsion. The Micro Modular Reactor design proposed in this paper has 3 meter diameter core (2 meter active core) which is suitable for 'factory manufactured' and has few tens year of service life for remote deployment. We confirmed the feasibility of long term service life by a preliminary neutronic analysis in terms of the excess reactivity, the temperature feedback coefficient, and the control margins. We are able to achieve a reasonably long core life time of 5 ∼ 10 years under typical thermal hydraulic condition of a helium cooled reactor. However, on a situation where longer service period and safety is important, we can reduce the power density to the level of typical pebble bed reactor. In this case we can design 10 MWt MMR with core diameter for 10 ∼ 40 years core life time without much loss in the economics. Several burnable poisons are studied and it is found that erbia mixed in the compact matrix seems reasonably good poison. The temperature feedback coefficients were remaining negative during lifetime. Drum type control rods at reflector region and few control rods inside core region are sufficient to control the reactivity during operation and to achieve safe cold shutdown state.

  7. Accelerated Sensitivity Analysis in High-Dimensional Stochastic Reaction Networks.

    Science.gov (United States)

    Arampatzis, Georgios; Katsoulakis, Markos A; Pantazis, Yannis

    2015-01-01

    Existing sensitivity analysis approaches are not able to handle efficiently stochastic reaction networks with a large number of parameters and species, which are typical in the modeling and simulation of complex biochemical phenomena. In this paper, a two-step strategy for parametric sensitivity analysis for such systems is proposed, exploiting advantages and synergies between two recently proposed sensitivity analysis methodologies for stochastic dynamics. The first method performs sensitivity analysis of the stochastic dynamics by means of the Fisher Information Matrix on the underlying distribution of the trajectories; the second method is a reduced-variance, finite-difference, gradient-type sensitivity approach relying on stochastic coupling techniques for variance reduction. Here we demonstrate that these two methods can be combined and deployed together by means of a new sensitivity bound which incorporates the variance of the quantity of interest as well as the Fisher Information Matrix estimated from the first method. The first step of the proposed strategy labels sensitivities using the bound and screens out the insensitive parameters in a controlled manner. In the second step of the proposed strategy, a finite-difference method is applied only for the sensitivity estimation of the (potentially) sensitive parameters that have not been screened out in the first step. Results on an epidermal growth factor network with fifty parameters and on a protein homeostasis with eighty parameters demonstrate that the proposed strategy is able to quickly discover and discard the insensitive parameters and in the remaining potentially sensitive parameters it accurately estimates the sensitivities. The new sensitivity strategy can be several times faster than current state-of-the-art approaches that test all parameters, especially in "sloppy" systems. In particular, the computational acceleration is quantified by the ratio between the total number of parameters over the

  8. Preliminary evaluation of diabatic heating distribution from FGGE level 3b analysis data

    Science.gov (United States)

    Kasahara, A.; Mizzi, A. P.

    1985-01-01

    A method is presented for calculating the global distribution of diabatic heating rate. Preliminary results of global heating rate evaluated from the European center for Medium Range Weather Forecasts Level IIIb analysis data is also presented.

  9. Chemistry in Protoplanetary Disks: A Sensitivity Analysis

    CERN Document Server

    Vasyunin, A I; Henning, T; Wakelam, V; Herbst, E; Sobolev, A M

    2007-01-01

    We study how uncertainties in the rate coefficients of chemical reactions in the RATE06 database affect abundances and column densities of key molecules in protoplanetary disks. We randomly varied the gas-phase reaction rates within their uncertainty limits and calculated the time-dependent abundances and column densities using a gas-grain chemical model and a flaring steady-state disk model. We find that key species can be separated into two distinct groups according to the sensitivity of their column densities to the rate uncertainties. The first group includes CO, C$^+$, H$_3^+$, H$_2$O, NH$_3$, N$_2$H$^+$, and HCNH$^+$. For these species, the column densities are not very sensitive to the rate uncertainties but the abundances in specific regions are. The second group includes CS, CO$_2$, HCO$^+$, H$_2$CO, C$_2$H, CN, HCN, HNC and other, more complex species, for which high abundances and abundance uncertainties co-exist in the same disk region, leading to larger scatters in the column densities. However, ...

  10. The Organic Food Market and Marketing Initiatives in Europe: a Preliminary Analysis

    DEFF Research Database (Denmark)

    Kristensen, Niels Heine; Nielsen, Thorkild; Bruselius-Jensen, Maria Louisa

    2003-01-01

    Kristensen NH, Nielsen T, Bruselius-Jensen M, Scheperlen-Bøgh P, Beckie M, Foster C, Midmore P, Padel S (2002): The Organic Food Market and Marketing Initiatives in Europe: a Preliminary Analysis. Final Report to the EU Commission......Kristensen NH, Nielsen T, Bruselius-Jensen M, Scheperlen-Bøgh P, Beckie M, Foster C, Midmore P, Padel S (2002): The Organic Food Market and Marketing Initiatives in Europe: a Preliminary Analysis. Final Report to the EU Commission...

  11. Preliminary Analysis of a Fully Solid State Magnetocaloric Refrigeration

    Energy Technology Data Exchange (ETDEWEB)

    Abdelaziz, Omar [ORNL

    2016-01-01

    Magnetocaloric refrigeration is an alternative refrigeration technology with significant potential energy savings compared to conventional vapor compression refrigeration technology. Most of the reported active magnetic regenerator (AMR) systems that operate based on the magnetocaloric effect use heat transfer fluid to exchange heat, which results in complicated mechanical subsystems and components such as rotating valves and hydraulic pumps. In this paper, we propose an alternative mechanism for heat transfer between the AMR and the heat source/sink. High-conductivity moving rods/sheets (e.g. copper, brass, iron, graphite, aluminum or composite structures from these) are utilized instead of heat transfer fluid significantly enhancing the heat transfer rate hence cooling/heating capacity. A one-dimensional model is developed to study the solid state AMR. In this model, the heat exchange between the solid-solid interfaces is modeled via a contact conductance, which depends on the interface apparent pressure, material hardness, thermal conductivity, surface roughness, surface slope between the interfaces, and material filled in the gap between the interfaces. Due to the tremendous impact of the heat exchange on the AMR cycle performance, a sensitivity analysis is conducted employing a response surface method, in which the apparent pressure, effective surface roughness and grease thermal conductivity are the uncertainty factors. COP and refrigeration capacity are presented as the response in the sensitivity analysis to reveal the important factors influencing the fully solid state AMR and optimize the solid state AMR efficiency. The performances of fully solid state AMR and traditional AMR are also compared and discussed in present work. The results of this study will provide general guidelines for designing high performance solid state AMR systems.

  12. Preliminary study on washability and composition analysis of highsulfur coal in some mining areas in Guizhou

    Institute of Scientific and Technical Information of China (English)

    QIU Yue-qin; MAO Song; ZHANG Qin; TIAN Ye; LIU Zhi-hong

    2011-01-01

    Preliminary sink-float experiments on high-sulfur coal was done in some mining areas and carried on elementary analysis, industrial analysis, and ashcontent analysis. Through the experiments, definite middlings, and gangue, the phase analysis of sulfur was carried on, by which a good understanding of sulfur characters in raw coal was achieved.

  13. Least Squares Shadowing for Sensitivity Analysis of Turbulent Fluid Flows

    CERN Document Server

    Blonigan, Patrick; Wang, Qiqi

    2014-01-01

    Computational methods for sensitivity analysis are invaluable tools for aerodynamics research and engineering design. However, traditional sensitivity analysis methods break down when applied to long-time averaged quantities in turbulent fluid flow fields, specifically those obtained using high-fidelity turbulence simulations. This is because of a number of dynamical properties of turbulent and chaotic fluid flows, most importantly high sensitivity of the initial value problem, popularly known as the "butterfly effect". The recently developed least squares shadowing (LSS) method avoids the issues encountered by traditional sensitivity analysis methods by approximating the "shadow trajectory" in phase space, avoiding the high sensitivity of the initial value problem. The following paper discusses how the least squares problem associated with LSS is solved. Two methods are presented and are demonstrated on a simulation of homogeneous isotropic turbulence and the Kuramoto-Sivashinsky (KS) equation, a 4th order c...

  14. Concrete spalling sensitivity versus microstructure: Preliminary results on the effect of polypropylene fibers

    Directory of Open Access Journals (Sweden)

    Rossino Chiara

    2013-09-01

    Full Text Available The phisyco-mechanical processes triggering concrete explosive spalling are related to the heat-induced micro- and meso-structural changes. To have new information on concrete properties at the microstructural level, as well as on how concrete spalling sensitivity is affected by polypropylene and steel fibers, and by aggregate type, ordinary and high-performance concretes are investigated in this research project, after being heated to different temperatures. The focus is on the relationship among porosity, vapor permeability, pore pressure and microcracking inside the cementitious matrix. Polypropylene fibers are shown to increase the total porosity, to favor microcracking and to reduce significantly pore pressure, to the advantage of concrete resistance to explosive spalling, whose risk is markedly reduced – or even zeroed.

  15. Cusum charts for preliminary analysis of individual observations

    NARCIS (Netherlands)

    A.J. Koning (Alex); R.J.M.M. Does (Ronald)

    1997-01-01

    textabstractA preliminary Cusum chart based on individual observations is developed from the uniformly most powerful test for the detection of linear trends. This Cusum chart is compared with several of its competitors which are based on the likelihood ratio test and on transformations of standardiz

  16. Sensitivity Analysis of the Critical Speed in Railway Vehicle Dynamics

    DEFF Research Database (Denmark)

    Bigoni, Daniele; True, Hans; Engsig-Karup, Allan Peter

    2014-01-01

    We present an approach to global sensitivity analysis aiming at the reduction of its computational cost without compromising the results. The method is based on sampling methods, cubature rules, High-Dimensional Model Representation and Total Sensitivity Indices. The approach has a general applic...

  17. Sensitivity Analysis of the Critical Speed in Railway Vehicle Dynamics

    DEFF Research Database (Denmark)

    Bigoni, Daniele; True, Hans; Engsig-Karup, Allan Peter

    2013-01-01

    We present an approach to global sensitivity analysis aiming at the reduction of its computational cost without compromising the results. The method is based on sampling methods, cubature rules, High-Dimensional Model Representation and Total Sensitivity Indices. The approach has a general applic...

  18. Global and local sensitivity analysis methods for a physical system

    Energy Technology Data Exchange (ETDEWEB)

    Morio, Jerome, E-mail: jerome.morio@onera.fr [Onera-The French Aerospace Lab, F-91761, Palaiseau Cedex (France)

    2011-11-15

    Sensitivity analysis is the study of how the different input variations of a mathematical model influence the variability of its output. In this paper, we review the principle of global and local sensitivity analyses of a complex black-box system. A simulated case of application is given at the end of this paper to compare both approaches.

  19. Electromagnetic and seismoelectric sensitivity analysis using resolution functions

    NARCIS (Netherlands)

    Maas, P.J.; Grobbe, N.; Slob, E.C.; Mulder, W.A.

    2015-01-01

    For multi-parameter problems, such as the seismoelectric system, sensitivity analysis through resolution functions is a low-cost, fast method of determining whether measured fields are sensitive to certain subsurface parameters. We define a seismoelectric resolution function for the inversion of a

  20. Global and Local Sensitivity Analysis Methods for a Physical System

    Science.gov (United States)

    Morio, Jerome

    2011-01-01

    Sensitivity analysis is the study of how the different input variations of a mathematical model influence the variability of its output. In this paper, we review the principle of global and local sensitivity analyses of a complex black-box system. A simulated case of application is given at the end of this paper to compare both approaches.…

  1. Adjoint sensitivity analysis of high frequency structures with Matlab

    CERN Document Server

    Bakr, Mohamed; Demir, Veysel

    2017-01-01

    This book covers the theory of adjoint sensitivity analysis and uses the popular FDTD (finite-difference time-domain) method to show how wideband sensitivities can be efficiently estimated for different types of materials and structures. It includes a variety of MATLAB® examples to help readers absorb the content more easily.

  2. Preliminary Rock Physics Analysis on Lodgepole Formation in Manitoba, Canada

    Science.gov (United States)

    Kim, N.; Keehm, Y.

    2012-12-01

    We present rock physics analysis results of Lodgepole Formation, a carbonate reservoir in Daly Field, Manitoba, Canada. We confirmed that the Lodgepole Formation can be divided into six units in the study area: Basal Limestone, Cromer Shale, Cruickshank Crinoidal, Cruickshank Shale, Daly member and Flossie Lake member from the bottom, using eight well log data and previous works. We then performed rock physics analyses on four carbonate units (Basal Limestone, Cruickshank Crinoidal, Daly and Flossie Lake), such as Vp-porosity, AI-porosity, DEM (differential effective medium) modeling, and fluid substitution analysis. In Vp-porosity domain, the top unit, Flossie Lake member has lower porosity and higher velocity, while the other units show similar porosity and velocity. We think that this results from the diagenesis of Flossie Lake member since it bounds with unconformity. However, the four units show very similar trend in Vp-porosity domain, and we can report one Vp-porosity relation for all carbonate units of the Lodgepole formation. We also found that the acoustic impedance varies more than 10% from low porosity zone (3-6%) to high porosity zone (9-12%) from AI-porosity analysis. Thus one can delineate high porosity zone from seismic impedance data. DEM modeling showed that Flossie Lake would have relatively low aspect ratio of pores than the others, which implies that the top unit has been influenced by diagenesis. To determine fluid sensitivity of carbonate units, we conducted fluid substitution on four units from 100% water to 100% oil. The top unit, Flossie Lake, showed slight increase of Vp, which seems to be density effect. The others showed small decrease of Vp, but not significant. If we observe Vp/Vs rather than Vp, the sensitivity increases. However, fluid discrimination would be difficult because of high stiffness of rock frame. In summary, three lower carbonate units of Lodgepole Formation would be prospective and high porosity zone can be delineated

  3. Temperature-sensitive mutants of Pseudomonas aeruginosa: isolation and preliminary immunological evaluation.

    Science.gov (United States)

    Hooke, A M; Arroyo, P J; Oeschger, M P; Bellanti, J A

    1982-01-01

    The immunogenicity of two temperature-sensitive (ts) mutants of Pseudomonas aeruginosa immunotype 1, isolated and characterized for the development of a safe, live vaccine strain, was evaluated in a mouse protection model. One mutant, A/10/25, had a limited "coasting" property (i.e., continued replication for two divisions) at the nonpermissive temperature (36 degrees C), whereas the other mutant, E/9/9, continued replication for five generations after transfer to 36 degrees C. Groups of 3- to 5-week-old ICR mice were immunized intraperitoneally with various doses of the two ts mutants; at various times thereafter, the mice were challenged intraperitoneally with lethal doses of the parental wild type. The more extensive coaster, E/9/9, induced 100% protection at immunizing doses lower than those required for A/10/25 to induce the same protection (1 x 10(8) to 2 x 10(8) and 6 x 10(8) colony-forming units, respectively). Both ts strains induced significant protection for up to 5 weeks after immunization. The results of these studies suggest that the use of P. aeruginosa ts mutants might provide a novel approach to the prevention of P. aeruginosa colonization of patients with cystic fibrosis. PMID:6815088

  4. Preliminary Study of Position-Sensitive Large-Area Radiation Portal Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Chang Hwy; Kim, Hyunok; Moon, Myung Kook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Jongyul [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Park, Jong Won; Lim, Yong Kon [Korea Institute of Ocean Science and Technology, Daejeon (Korea, Republic of)

    2013-10-15

    An RPM, which is a passive inspection method, is a system for monitoring the movement of radioactive materials at an airport, seaport, border, etc. To detect a γ-ray, an RPM using the plastic scintillator is generally used. The method of γ-ray detection using an RPM with a plastic scintillator is to measure lights generated by an incident γ-ray in the scintillator. Generally, a large-area RPM uses one or two photomultiplier tubes (PMT) for light collection. However, in this study, we developed a 4-ch RPM that can measure the radiation signal using 4 PMTs. The reason for using 4 PMTs is to calculate the position of the radiation source. In addition, we developed an electric device for acquisition of a 4-ch output signal at the same time. To estimate the performance of the developed RPM, we performed an RPM test using a {sup 60}Co γ-ray check source. In this study, we performed the development of a 4-ch RPM. The major function of the typical RPM is to measure the radiation. However, we developed a position-sensitive 4-ch RPM, which can be used to measure the location of the radiation source, as well as the radiation measurement, at the same time. In the future, we plan to develop an algorithm for a position detection of the radiation. In addition, an algorithm will be applied to an RPM.

  5. Sensitivity Analysis of the Gap Heat Transfer Model in BISON.

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton; Schmidt, Rodney C.; Williamson, Richard (INL); Perez, Danielle (INL)

    2014-10-01

    This report summarizes the result of a NEAMS project focused on sensitivity analysis of the heat transfer model in the gap between the fuel rod and the cladding used in the BISON fuel performance code of Idaho National Laboratory. Using the gap heat transfer models in BISON, the sensitivity of the modeling parameters and the associated responses is investigated. The study results in a quantitative assessment of the role of various parameters in the analysis of gap heat transfer in nuclear fuel.

  6. Sensitivity analysis on fuel scenario associated magnitudes

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Martinez, M.; Alvarez-Velarde, F.

    2014-07-01

    Nuclear fuel cycle scenario analyses are needed as a support for policy makers in terms of sustainability, fuel diversity, security of supply, and social and environmental effects. These analyses are usually aimed to the study of the impact of certain hypotheses on some fuel cycle indicators, without considering the uncertainties on those hypotheses. The expert group of the NEA/OECD on Advanced Fuel Cycle Scenarios, where this work is framed, is devoted to fill this gap, laying the foundations for deep analysis of the sensibilities on fuel cycle indicators. (Author)

  7. Dispersion sensitivity analysis & consistency improvement of APFSDS

    Directory of Open Access Journals (Sweden)

    Sangeeta Sharma Panda

    2017-08-01

    In Bore Balloting Motion simulation shows that reduction in residual spin by about 5% results in drastic 56% reduction in first maximum yaw. A correlation between first maximum yaw and residual spin is observed. Results of data analysis are used in design modification for existing ammunition. Number of designs are evaluated numerically before freezing five designs for further soundings. These designs are critically assessed in terms of their comparative performance during In-bore travel & external ballistics phase. Results are validated by free flight trials for the finalised design.

  8. Fixed point sensitivity analysis of interacting structured populations.

    Science.gov (United States)

    Barabás, György; Meszéna, Géza; Ostling, Annette

    2014-03-01

    Sensitivity analysis of structured populations is a useful tool in population ecology. Historically, methodological development of sensitivity analysis has focused on the sensitivity of eigenvalues in linear matrix models, and on single populations. More recently there have been extensions to the sensitivity of nonlinear models, and to communities of interacting populations. Here we derive a fully general mathematical expression for the sensitivity of equilibrium abundances in communities of interacting structured populations. Our method yields the response of an arbitrary function of the stage class abundances to perturbations of any model parameters. As a demonstration, we apply this sensitivity analysis to a two-species model of ontogenetic niche shift where each species has two stage classes, juveniles and adults. In the context of this model, we demonstrate that our theory is quite robust to violating two of its technical assumptions: the assumption that the community is at a point equilibrium and the assumption of infinitesimally small parameter perturbations. Our results on the sensitivity of a community are also interpreted in a niche theoretical context: we determine how the niche of a structured population is composed of the niches of the individual states, and how the sensitivity of the community depends on niche segregation.

  9. Cooling via one hand improves physical performance in heat-sensitive individuals with Multiple Sclerosis: A preliminary study

    Directory of Open Access Journals (Sweden)

    Murray Julie

    2008-05-01

    Full Text Available Abstract Background Many individuals afflicted with multiple sclerosis (MS experience a transient worsening of symptoms when body temperature increases due to ambient conditions or physical activity. Resulting symptom exacerbations can limit performance. We hypothesized that extraction of heat from the body through the subcutaneous retia venosa that underlie the palmar surfaces of the hands would reduce exercise-related heat stress and thereby increase the physical performance capacity of heat-sensitive individuals with MS. Methods Ten ambulatory MS patients completed one or more randomized paired trials of walking on a treadmill in a temperate environment with and without cooling. Stop criteria were symptom exacerbation and subjective fatigue. The cooling treatment entailed inserting one hand into a rigid chamber through an elastic sleeve that formed an airtight seal around the wrist. A small vacuum pump created a -40 mm Hg subatmospheric pressure enviinside the chamber where the palmar surface of the hand rested on a metal surface maintained at 18–22°C. During the treatment trials, the device was suspended from above the treadmill on a bungee cord so the subjects could comfortably keep a hand in the device without having to bear its weight while walking on the treadmill. Results When the trials were grouped by treatment only, cooling treatment increased exercise durations by 33% (43.6 ± 17.1 min with treatment vs. 32.8 ± 10.9 min. without treatment, mean ± SD, p -6, paired t-test, n = 26. When the average values were calculated for the subjects who performed multiple trials before the treatment group results were compared, cooling treatment increased exercise duration by 35% (42.8 ± 16.4 min with treatment vs. 31.7 ± 9.8 min. without treatment, mean ± SD, p Conclusion These preliminary results suggest that utilization of the heat transfer capacity of the non-hairy skin surfaces can enable temperature-sensitive individuals with MS to

  10. Stochastic sensitivity analysis using HDMR and score function

    Indian Academy of Sciences (India)

    Rajib Chowdhury; B N Rao; A Meher Prasad

    2009-12-01

    Probabilistic sensitivities provide an important insight in reliability analysis and often crucial towards understanding the physical behaviour underlying failure and modifying the design to mitigate and manage risk. This article presents a new computational approach for calculating stochastic sensitivities of mechanical systems with respect to distribution parameters of random variables. The method involves high dimensional model representation and score functions associated with probability distribution of a random input. The proposed approach facilitates first-and second-order approximation of stochastic sensitivity measures and statistical simulation. The formulation is general such that any simulation method can be used for the computation such as Monte Carlo, importance sampling, Latin hypercube, etc. Both the probabilistic response and its sensitivities can be estimated from a single probabilistic analysis, without requiring gradients of performance function. Numerical results indicate that the proposed method provides accurate and computationally efficient estimates of sensitivities of statistical moments or reliability of structural system.

  11. Advancing sensitivity analysis to precisely characterize temporal parameter dominance

    Science.gov (United States)

    Guse, Björn; Pfannerstill, Matthias; Strauch, Michael; Reusser, Dominik; Lüdtke, Stefan; Volk, Martin; Gupta, Hoshin; Fohrer, Nicola

    2016-04-01

    Parameter sensitivity analysis is a strategy for detecting dominant model parameters. A temporal sensitivity analysis calculates daily sensitivities of model parameters. This allows a precise characterization of temporal patterns of parameter dominance and an identification of the related discharge conditions. To achieve this goal, the diagnostic information as derived from the temporal parameter sensitivity is advanced by including discharge information in three steps. In a first step, the temporal dynamics are analyzed by means of daily time series of parameter sensitivities. As sensitivity analysis method, we used the Fourier Amplitude Sensitivity Test (FAST) applied directly onto the modelled discharge. Next, the daily sensitivities are analyzed in combination with the flow duration curve (FDC). Through this step, we determine whether high sensitivities of model parameters are related to specific discharges. Finally, parameter sensitivities are separately analyzed for five segments of the FDC and presented as monthly averaged sensitivities. In this way, seasonal patterns of dominant model parameter are provided for each FDC segment. For this methodical approach, we used two contrasting catchments (upland and lowland catchment) to illustrate how parameter dominances change seasonally in different catchments. For all of the FDC segments, the groundwater parameters are dominant in the lowland catchment, while in the upland catchment the controlling parameters change seasonally between parameters from different runoff components. The three methodical steps lead to clear temporal patterns, which represent the typical characteristics of the study catchments. Our methodical approach thus provides a clear idea of how the hydrological dynamics are controlled by model parameters for certain discharge magnitudes during the year. Overall, these three methodical steps precisely characterize model parameters and improve the understanding of process dynamics in hydrological

  12. Current Mooring Design in Partner WECs and Candidates for Preliminary Analysis

    DEFF Research Database (Denmark)

    Thomsen, Jonas Bjerg; Ferri, Francesco; Kofoed, Jens Peter

    This report is the combined report of Commercial Milestone "CM1: Design and Cost of Current Mooring Solutions of Partner WECs" and Milestone "M3: Mooring Solutions for Preliminary Analysis" of the EUDP project "Mooring Solutions for Large Wave Energy Converters". The report covers a description...... of the current mooring design of the partner Wave Energy Converter (WEC) developers in the project, together with a preliminary cost estimate of the systems....

  13. Application of Stochastic Sensitivity Analysis to Integrated Force Method

    Directory of Open Access Journals (Sweden)

    X. F. Wei

    2012-01-01

    Full Text Available As a new formulation in structural analysis, Integrated Force Method has been successfully applied to many structures for civil, mechanical, and aerospace engineering due to the accurate estimate of forces in computation. Right now, it is being further extended to the probabilistic domain. For the assessment of uncertainty effect in system optimization and identification, the probabilistic sensitivity analysis of IFM was further investigated in this study. A set of stochastic sensitivity analysis formulation of Integrated Force Method was developed using the perturbation method. Numerical examples are presented to illustrate its application. Its efficiency and accuracy were also substantiated with direct Monte Carlo simulations and the reliability-based sensitivity method. The numerical algorithm was shown to be readily adaptable to the existing program since the models of stochastic finite element and stochastic design sensitivity are almost identical.

  14. Preliminary Design and Analysis of the GIFTS Instrument Pointing System

    Science.gov (United States)

    Zomkowski, Paul P.

    2003-01-01

    The Geosynchronous Imaging Fourier Transform Spectrometer (GIFTS) Instrument is the next generation spectrometer for remote sensing weather satellites. The GIFTS instrument will be used to perform scans of the Earth s atmosphere by assembling a series of field-of- views (FOV) into a larger pattern. Realization of this process is achieved by step scanning the instrument FOV in a contiguous fashion across any desired portion of the visible Earth. A 2.3 arc second pointing stability, with respect to the scanning instrument, must be maintained for the duration of the FOV scan. A star tracker producing attitude data at 100 Hz rate will be used by the autonomous pointing algorithm to precisely track target FOV s on the surface of the Earth. The main objective is to validate the pointing algorithm in the presence of spacecraft disturbances and determine acceptable disturbance limits from expected noise sources. Proof of concept validation of the pointing system algorithm is carried out with a full system simulation developed using Matlab Simulink. Models for the following components function within the full system simulation: inertial reference unit (IRU), attitude control system (ACS), reaction wheels, star tracker, and mirror controller. With the spacecraft orbital position and attitude maintained to within specified limits the pointing algorithm receives quaternion, ephemeris, and initialization data that are used to construct the required mirror pointing commands at a 100 Hz rate. This comprehensive simulation will also aid in obtaining a thorough understanding of spacecraft disturbances and other sources of pointing system errors. Parameter sensitivity studies and disturbance analysis will be used to obtain limits of operability for the GIFTS instrument. The culmination of this simulation development and analysis will be used to validate the specified performance requirements outlined for this instrument.

  15. Global sensitivity analysis in stochastic simulators of uncertain reaction networks

    Science.gov (United States)

    Navarro Jimenez, M.; Le Maître, O. P.; Knio, O. M.

    2016-12-01

    Stochastic models of chemical systems are often subjected to uncertainties in kinetic parameters in addition to the inherent random nature of their dynamics. Uncertainty quantification in such systems is generally achieved by means of sensitivity analyses in which one characterizes the variability with the uncertain kinetic parameters of the first statistical moments of model predictions. In this work, we propose an original global sensitivity analysis method where the parametric and inherent variability sources are both treated through Sobol's decomposition of the variance into contributions from arbitrary subset of uncertain parameters and stochastic reaction channels. The conceptual development only assumes that the inherent and parametric sources are independent, and considers the Poisson processes in the random-time-change representation of the state dynamics as the fundamental objects governing the inherent stochasticity. A sampling algorithm is proposed to perform the global sensitivity analysis, and to estimate the partial variances and sensitivity indices characterizing the importance of the various sources of variability and their interactions. The birth-death and Schlögl models are used to illustrate both the implementation of the algorithm and the richness of the proposed analysis method. The output of the proposed sensitivity analysis is also contrasted with a local derivative-based sensitivity analysis method classically used for this type of systems.

  16. Global sensitivity analysis in stochastic simulators of uncertain reaction networks

    KAUST Repository

    Navarro Jimenez, M.

    2016-12-26

    Stochastic models of chemical systems are often subjected to uncertainties in kinetic parameters in addition to the inherent random nature of their dynamics. Uncertainty quantification in such systems is generally achieved by means of sensitivity analyses in which one characterizes the variability with the uncertain kinetic parameters of the first statistical moments of model predictions. In this work, we propose an original global sensitivity analysis method where the parametric and inherent variability sources are both treated through Sobol’s decomposition of the variance into contributions from arbitrary subset of uncertain parameters and stochastic reaction channels. The conceptual development only assumes that the inherent and parametric sources are independent, and considers the Poisson processes in the random-time-change representation of the state dynamics as the fundamental objects governing the inherent stochasticity. A sampling algorithm is proposed to perform the global sensitivity analysis, and to estimate the partial variances and sensitivity indices characterizing the importance of the various sources of variability and their interactions. The birth-death and Schlögl models are used to illustrate both the implementation of the algorithm and the richness of the proposed analysis method. The output of the proposed sensitivity analysis is also contrasted with a local derivative-based sensitivity analysis method classically used for this type of systems.

  17. Global sensitivity analysis in stochastic simulators of uncertain reaction networks.

    Science.gov (United States)

    Navarro Jimenez, M; Le Maître, O P; Knio, O M

    2016-12-28

    Stochastic models of chemical systems are often subjected to uncertainties in kinetic parameters in addition to the inherent random nature of their dynamics. Uncertainty quantification in such systems is generally achieved by means of sensitivity analyses in which one characterizes the variability with the uncertain kinetic parameters of the first statistical moments of model predictions. In this work, we propose an original global sensitivity analysis method where the parametric and inherent variability sources are both treated through Sobol's decomposition of the variance into contributions from arbitrary subset of uncertain parameters and stochastic reaction channels. The conceptual development only assumes that the inherent and parametric sources are independent, and considers the Poisson processes in the random-time-change representation of the state dynamics as the fundamental objects governing the inherent stochasticity. A sampling algorithm is proposed to perform the global sensitivity analysis, and to estimate the partial variances and sensitivity indices characterizing the importance of the various sources of variability and their interactions. The birth-death and Schlögl models are used to illustrate both the implementation of the algorithm and the richness of the proposed analysis method. The output of the proposed sensitivity analysis is also contrasted with a local derivative-based sensitivity analysis method classically used for this type of systems.

  18. Preliminary Dynamic Siol-Structure-Interaction Analysis for the Waste Handling Building

    Energy Technology Data Exchange (ETDEWEB)

    G. Wagenblast

    2000-05-01

    The objective of this analysis package is to document a preliminary dynamic seismic evaluation of a simplified design concept of the Wade Handling Building (WHB). Preliminary seismic ground motions and soil data will be used. Loading criteria of the WHB System Design Description will be used. Detail design of structural members will not be performed.. The results of the analysis will be used to determine preliminary sizes of structural concrete and steel members and to determine whether the seismic response of the structure is within an acceptable level for future License Application design of safety related facilities. In order to complete this preliminary dynamic evaluation to meet the Site Recommendation (SR) schedule, the building configuration was ''frozen in time'' as the conceptual design existed in October 1999. Modular design features and dry or wet waste storage features were intentionally excluded from this preliminary dynamic seismic evaluation. The document was prepared in accordance with the Development Plan for the ''Preliminary/Dynamic Soil Structure Interaction Analysis for the Waste Handling Building'' (CRWMS M&O 2000b), which was completed, in accordance with AP-2.13Q, ''Technical Product Development Planning''.

  19. SINGLE-SHELL TANK INTEGRITY PROJECT ANALYSIS OF RECORD-PRELIMINARY MODELING PLAN FOR THERMAL AND OPERATING LOADS

    Energy Technology Data Exchange (ETDEWEB)

    RAST RS; RINKER MW; BAPANAALLI SK; DEIBLER JE; GUZMAN-LEONG CE; JOHNSON KI; KARRI NK; PILLI SP; SANBORN SE

    2010-10-22

    This document is a Phase I deliverable for the Single-Shell Tank Analysis of Record effort. This document is not the Analysis of Record. The intent of this document is to guide the Phase II detailed modeling effort. Preliminary finite element models for each of the tank types were developed and different case studies were performed on one or more of these tank types. Case studies evaluated include thermal loading, waste level variation, the sensitivity of boundary effects (soil radial extent), excavation slope or run to rise ratio, soil stratigraphic (property and layer thickness) variation at different farm locations, and concrete material property variation and their degradation under thermal loads. The preliminary analysis document reviews and preliminary modeling analysis results are reported herein. In addition, this report provides recommendations for the next phase of the SST AOR project, SST detailed modeling. Efforts and results discussed in this report do not include seismic modeling as seismic modeling is covered by a separate report. The combined results of both static and seismic models are required to complete this effort. The SST AOR project supports the US Department of Energy's (DOE) Office of River Protection (ORP) mission for obtaining a better understanding of the structural integrity of Hanford's SSTs. The 149 SSTs, with six different geometries, have experienced a range of operating histories which would require a large number of unique analyses to fully characterize their individual structural integrity. Preliminary modeling evaluations were conducted to determine the number of analyses required for adequate bounding of each of the SST tank types in the Detailed Modeling Phase of the SST AOR Project. The preliminary modeling was conducted in conjunction with the Evaluation Criteria report, Johnson et al. (2010). Reviews of existing documents were conducted at the initial stage of preliminary modeling. These reviews guided the topics

  20. Thermal Hydraulic Analysis of K-DEMO Single Blanket Module for Preliminary Accident Analysis using MELCOR

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Sung Bo; Bang, In Cheol [UNIST, Ulsan (Korea, Republic of)

    2016-05-15

    To develop the Korean fusion commercial reactor, preliminary design concept for K-DEMO (Korean fusion demonstration reactor) has been announced by NFRI (National Fusion Research Institute). This pre-conceptual study of K-DEMO has been introduced to identify technical details of a fusion power plant for the future commercialization of fusion reactor in Korea. Before this consideration, to build the K-DEMO, accident analysis is essential. Since the Fukushima accident, which is severe accident from unexpected disaster, safety analysis of nuclear power plant has become important. The safety analysis of both fission and fusion reactors is deemed crucial in demonstrating the low radiological effect of these reactors on the environment, during severe accidents. A risk analysis of K-DEMO should be performed, as a prerequisite for the construction of a fusion reactor. In this research, thermal-hydraulic analysis of single blanket module of K-DEMO is conducted for preliminary accident analysis for K-DEMO. Further study about effect of flow distributer is conducted. The normal K-DEMO operation condition is applied to the boundary condition and simulated to verify the material temperature limit using MELCOR. MELCOR is fully integrated, relatively fast-running code developed by Sandia National Laboratories. MELCOR had been used for Light Water Reactors and fusion reactor version of MELCOR was developed for ITER accident analysis. This study shows the result of thermal-hydraulic simulation of single blanket module with MELCOR which is severe accident code for nuclear fusion safety analysis. The difference of mass flow rate for each coolant channel with or without flow distributer is presented. With flow distributer, advantage of broadening temperature gradient in the K-DEMO blanket module and increase mass flow toward first wall is obtained. This can enhance the safety of K-DEMO blanket module. Most 13 .deg. C temperature difference in blanket module is obtained.

  1. A Novel Multiobjective Optimization Method Based on Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    Tiane Li

    2016-01-01

    Full Text Available For multiobjective optimization problems, different optimization variables have different influences on objectives, which implies that attention should be paid to the variables according to their sensitivity. However, previous optimization studies have not considered the variables sensitivity or conducted sensitivity analysis independent of optimization. In this paper, an integrated algorithm is proposed, which combines the optimization method SPEA (Strength Pareto Evolutionary Algorithm with the sensitivity analysis method SRCC (Spearman Rank Correlation Coefficient. In the proposed algorithm, the optimization variables are worked as samples of sensitivity analysis, and the consequent sensitivity result is used to guide the optimization process by changing the evolutionary parameters. Three cases including a mathematical problem, an airship envelope optimization, and a truss topology optimization are used to demonstrate the computational efficiency of the integrated algorithm. The results showed that this algorithm is able to simultaneously achieve parameter sensitivity and a well-distributed Pareto optimal set, without increasing the computational time greatly in comparison with the SPEA method.

  2. Superconducting Accelerating Cavity Pressure Sensitivity Analysis and Stiffening

    Energy Technology Data Exchange (ETDEWEB)

    Rodnizki, J [Soreq NRC, Yavne, Israel; Ben Aliz, Y [Soreq NRC, Yavne, Israel; Grin, A [Soreq NRC, Yavne, Israel; Horvitz, Z [Soreq NRC, Yavne, Israel; Perry, A [Soreq NRC, Yavne, Israel; Weissman, L [Soreq NRC, Yavne, Israel; Davis, G Kirk [JLAB; Delayen, Jean R. [Old Dominion Universtiy

    2014-12-01

    The Soreq Applied Research Accelerator Facility (SARAF) design is based on a 40 MeV 5 mA light ions superconducting RF linac. Phase-I of SARAF delivers up to 2 mA CW proton beams in an energy range of 1.5 - 4.0 MeV. The maximum beam power that we have reached is 5.7 kW. Today, the main limiting factor to reach higher ion energy and beam power is related to the HWR sensitivity to the liquid helium coolant pressure fluctuations. The HWR sensitivity to helium pressure is about 60 Hz/mbar. The cavities had been designed, a decade ago, to be soft in order to enable tuning of their novel shape. However, the cavities turned out to be too soft. In this work we found that increasing the rigidity of the cavities in the vicinity of the external drift tubes may reduce the cavity sensitivity by a factor of three. A preliminary design to increase the cavity rigidity is presented.

  3. Sensitivity Analysis of Criticality for Different Nuclear Fuel Shapes

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyun Sik; Jang, Misuk; Kim, Seoung Rae [NESS, Daejeon (Korea, Republic of)

    2016-10-15

    Rod-type nuclear fuel was mainly developed in the past, but recent study has been extended to plate-type nuclear fuel. Therefore, this paper reviews the sensitivity of criticality according to different shapes of nuclear fuel types. Criticality analysis was performed using MCNP5. MCNP5 is well-known Monte Carlo codes for criticality analysis and a general-purpose Monte Carlo N-Particle code that can be used for neutron, photon, electron or coupled neutron / photon / electron transport, including the capability to calculate eigenvalues for critical systems. We performed the sensitivity analysis of criticality for different fuel shapes. In sensitivity analysis for simple fuel shapes, the criticality is proportional to the surface area. But for fuel Assembly types, it is not proportional to the surface area. In sensitivity analysis for intervals between plates, the criticality is greater as the interval increases, but if the interval is greater than 8mm, it showed an opposite trend that the criticality decrease by a larger interval. As a result, it has failed to obtain the logical content to be described in common for all cases. The sensitivity analysis of Criticality would be always required whenever subject to be analyzed is changed.

  4. Acoustic design sensitivity analysis of structural sound radiation

    Institute of Scientific and Technical Information of China (English)

    许智生

    2009-01-01

    This paper presents an acoustic design sensitivity(ADS)analysis on sound radiation of structures by using the boundary element method(BEM).We calculated the velocity distribution of the thin plate by analytical method and the surface sound pressure by Rayleigh integral,and expressed the sound radiation power of the structure in a positive definite quadratic form of the Hermitian with an impedance matrix.The ADS analysis of the plate was thus translated into the analysis of structure dynamic sensitivity and ...

  5. Sensitivity analysis of small circular cylinders as wake control

    Science.gov (United States)

    Meneghini, Julio; Patino, Gustavo; Gioria, Rafael

    2016-11-01

    We apply a sensitivity analysis to a steady external force regarding control vortex shedding from a circular cylinder using active and passive small control cylinders. We evaluate the changes on the flow produced by the device on the flow near the primary instability, transition to wake. We numerically predict by means of sensitivity analysis the effective regions to place the control devices. The quantitative effect of the hydrodynamic forces produced by the control devices is also obtained by a sensitivity analysis supporting the prediction of minimum rotation rate. These results are extrapolated for higher Reynolds. Also, the analysis provided the positions of combined passive control cylinders that suppress the wake. The latter shows that these particular positions for the devices are adequate to suppress the wake unsteadiness. In both cases the results agree very well with experimental cases of control devices previously published.

  6. A tool model for predicting atmospheric kinetics with sensitivity analysis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A package( a tool model) for program of predicting atmospheric chemical kinetics with sensitivity analysis is presented. The new direct method of calculating the first order sensitivity coefficients using sparse matrix technology to chemical kinetics is included in the tool model, it is only necessary to triangularize the matrix related to the Jacobian matrix of the model equation. The Gear type procedure is used to integrate amodel equation and its coupled auxiliary sensitivity coefficient equations. The FORTRAN subroutines of the model equation, the sensitivity coefficient equations, and their Jacobian analytical expressions are generated automatically from a chemical mechanism. The kinetic representation for the model equation and its sensitivity coefficient equations, and their Jacobian matrix is presented. Various FORTRAN subroutines in packages, such as SLODE, modified MA28, Gear package, with which the program runs in conjunction are recommended.The photo-oxidation of dimethyl disulfide is used for illustration.

  7. Sensitivity analysis, calibration, and testing of a distributed hydrological model using error-based weighting and one objective function

    Science.gov (United States)

    Foglia, L.; Hill, Mary C.; Mehl, Steffen W.; Burlando, P.

    2009-01-01

    We evaluate the utility of three interrelated means of using data to calibrate the fully distributed rainfall-runoff model TOPKAPI as applied to the Maggia Valley drainage area in Switzerland. The use of error-based weighting of observation and prior information data, local sensitivity analysis, and single-objective function nonlinear regression provides quantitative evaluation of sensitivity of the 35 model parameters to the data, identification of data types most important to the calibration, and identification of correlations among parameters that contribute to nonuniqueness. Sensitivity analysis required only 71 model runs, and regression required about 50 model runs. The approach presented appears to be ideal for evaluation of models with long run times or as a preliminary step to more computationally demanding methods. The statistics used include composite scaled sensitivities, parameter correlation coefficients, leverage, Cook's D, and DFBETAS. Tests suggest predictive ability of the calibrated model typical of hydrologic models.

  8. Cusum charts for preliminary analysis of individual observations

    OpenAIRE

    1997-01-01

    textabstractA preliminary Cusum chart based on individual observations is developed from the uniformly most powerful test for the detection of linear trends. This Cusum chart is compared with several of its competitors which are based on the likelihood ratio test and on transformations of standardized recursive residuals on which for instance the Q-chart methodology is based. It turns out that the new proposed Cusum chart is not only superior in the detection of linear trend out-of-control co...

  9. Grid-connected ICES preliminary feasibility analysis and evaluation. Final report. Volume I. Executive summary

    Energy Technology Data Exchange (ETDEWEB)

    1977-06-30

    A group of hospitals, clinics, research facilities, and medical education facilities, known as the HEAL Complex, was chosen as the site (in New Orleans) for the demonstration of a Grid-Connected Integrated Community Energy System (ICES). The contract work included a preliminary energy supply/demand assessment of the Demonstration Community, a preliminary feasibility analysis and conceptual design of a candidate Demonstration System, preliminary assessment of institutional factors, preparation of a detailed work management plan for subsequent phases of the demonstration program, firming-up of commitments from participating parties, and reporting thereon. This Phase I study has indicated that a central ICES plant producing steam, chilled water, and by-product electricity to serve the HEAL Complex is technically and economically feasible to the extent that Phase II, Detailed Feasibility and Preliminary Design, should be implemented. (MCW)

  10. Sensitivity Analysis of a Dynamical System Using C++

    Directory of Open Access Journals (Sweden)

    Donna Calhoun

    1993-01-01

    Full Text Available This article introduces basic principles of first order sensitivity analysis and presents an algorithm that can be used to compute the sensitivity of a dynamical system to a selected parameter. This analysis is performed by extending with sensitivity equations the set of differential equations describing the dynamical system. These additional equations require the evaluation of partial derivatives, and so a technique known as the table algorithm, which can be used to exactly and automatically compute these derivatives, is described. A C++ class which can be used to implement the table algorithm is presented along with a driver routine for evaluating the output of a model and its sensitivity to a single parameter. The use of this driver routine is illustrated with a specific application from environmental hazards modeling.

  11. Analysis of implicit and explicit lattice sensitivities using DRAGON

    Energy Technology Data Exchange (ETDEWEB)

    Ball, M.R., E-mail: ballmr@mcmaster.ca; Novog, D.R., E-mail: novog@mcmaster.ca; Luxat, J.C., E-mail: luxatj@mcmaster.ca

    2013-12-15

    Highlights: • We developed a way to propagate point-wise perturbations using only WIMS-D4 multigroup data. • The method inherently includes treatment of multi-group implicit sensitivities. • We compared our calculated sensitivities to an industry standard tool (TSUNAMI-1D). • In general, our results agreed well with TSUNAMI-1D. - Abstract: Deterministic lattice physics transport calculations are used extensively within the context of operational and safety analysis of nuclear power plants. As such the sensitivity and uncertainty in the evaluated nuclear data used to predict neutronic interactions and other key transport phenomena are critical topics for research. Sensitivity analysis of nuclear systems with respect to fundamental nuclear data using multi-energy-group discretization is complicated by the dilution dependency of multi-group macroscopic cross-sections as a result of resonance self-shielding. It has become common to group sensitivities into implicit and explicit effects to aid in the understanding of the nature of the sensitivities involved in the calculations, however the overall sensitivity is an integral of these effects. Explicit effects stem from perturbations performed for a specific nuclear data for a given isotope and at a specific energy, and their direct impact on the end figure of merit. Implicit effects stem from resonance self-shielding effects and can change the nature of their own sensitivities at other energies, or that for other reactions or even other isotopes. Quantification of the implicit sensitivity component involves some manner of treatment of resonance parameters in a way that is self-consistent with perturbations occurring in associated multi-group cross-sections. A procedure for assessing these implicit effects is described in the context of the Bondarenko method of self-shielding and implemented using a WIMS-D4 multi-group nuclear library and the lattice solver DRAGON. The resulting sensitivity results were compared

  12. Turbine Fuels from Tar Sands Bitumen and Heavy Oil. Phase I. Preliminary Process Analysis.

    Science.gov (United States)

    1985-04-09

    Process Analysis A. F. Talbot. V. Elanchenny, L. H. Finkel, A. Macris and 3. P. Schwedock Sun Tech, Inc., A Subsidiary of Sun Co. P. 0. Box 1135 Marcus Hook...investigation be carried out in three discrete phases, as described below: Phase I - Preliminary process analysis includes an eval- uation of the potential of

  13. A Preliminary Study on Gender Differences in Studying Systems Analysis and Design

    Science.gov (United States)

    Lee, Fion S. L.; Wong, Kelvin C. K.

    2017-01-01

    Systems analysis and design is a crucial task in system development and is included in a typical information systems programme as a core course. This paper presented a preliminary study on gender differences in studying a systems analysis and design course of an undergraduate programme. Results indicated that male students outperformed female…

  14. Noise analysis for sensitivity-based structural damage detection

    Institute of Scientific and Technical Information of China (English)

    YIN Tao; ZHU Hong-ping; YU Ling

    2007-01-01

    As vibration-based structural damage detection methods are easily affected by environmental noise, a new statistic-based noise analysis method is proposed together with the Monte Carlo technique to investigate the influence of experimental noise of modal data on sensitivity-based damage detection methods. Different from the commonly used random perturbation technique, the proposed technique is deduced directly by Moore-Penrose generalized inverse of the sensitivity matrix, which does not only make the analysis process more efficient but also can analyze the influence of noise on both frequencies and mode shapes for three commonly used sensitivity-based damage detection methods in a similar way. A one-story portal frame is adopted to evaluate the efficiency of the proposed noise analysis technique.

  15. Sensitivity analysis for missing data in regulatory submissions.

    Science.gov (United States)

    Permutt, Thomas

    2016-07-30

    The National Research Council Panel on Handling Missing Data in Clinical Trials recommended that sensitivity analyses have to be part of the primary reporting of findings from clinical trials. Their specific recommendations, however, seem not to have been taken up rapidly by sponsors of regulatory submissions. The NRC report's detailed suggestions are along rather different lines than what has been called sensitivity analysis in the regulatory setting up to now. Furthermore, the role of sensitivity analysis in regulatory decision-making, although discussed briefly in the NRC report, remains unclear. This paper will examine previous ideas of sensitivity analysis with a view to explaining how the NRC panel's recommendations are different and possibly better suited to coping with present problems of missing data in the regulatory setting. It will also discuss, in more detail than the NRC report, the relevance of sensitivity analysis to decision-making, both for applicants and for regulators. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

  16. Sensitivity analysis of a sound absorption model with correlated inputs

    Science.gov (United States)

    Chai, W.; Christen, J.-L.; Zine, A.-M.; Ichchou, M.

    2017-04-01

    Sound absorption in porous media is a complex phenomenon, which is usually addressed with homogenized models, depending on macroscopic parameters. Since these parameters emerge from the structure at microscopic scale, they may be correlated. This paper deals with sensitivity analysis methods of a sound absorption model with correlated inputs. Specifically, the Johnson-Champoux-Allard model (JCA) is chosen as the objective model with correlation effects generated by a secondary micro-macro semi-empirical model. To deal with this case, a relatively new sensitivity analysis method Fourier Amplitude Sensitivity Test with Correlation design (FASTC), based on Iman's transform, is taken into application. This method requires a priori information such as variables' marginal distribution functions and their correlation matrix. The results are compared to the Correlation Ratio Method (CRM) for reference and validation. The distribution of the macroscopic variables arising from the microstructure, as well as their correlation matrix are studied. Finally the results of tests shows that the correlation has a very important impact on the results of sensitivity analysis. Assessment of correlation strength among input variables on the sensitivity analysis is also achieved.

  17. Sensitivity analysis approach to multibody systems described by natural coordinates

    Science.gov (United States)

    Li, Xiufeng; Wang, Yabin

    2014-03-01

    The classical natural coordinate modeling method which removes the Euler angles and Euler parameters from the governing equations is particularly suitable for the sensitivity analysis and optimization of multibody systems. However, the formulation has so many principles in choosing the generalized coordinates that it hinders the implementation of modeling automation. A first order direct sensitivity analysis approach to multibody systems formulated with novel natural coordinates is presented. Firstly, a new selection method for natural coordinate is developed. The method introduces 12 coordinates to describe the position and orientation of a spatial object. On the basis of the proposed natural coordinates, rigid constraint conditions, the basic constraint elements as well as the initial conditions for the governing equations are derived. Considering the characteristics of the governing equations, the newly proposed generalized-α integration method is used and the corresponding algorithm flowchart is discussed. The objective function, the detailed analysis process of first order direct sensitivity analysis and related solving strategy are provided based on the previous modeling system. Finally, in order to verify the validity and accuracy of the method presented, the sensitivity analysis of a planar spinner-slider mechanism and a spatial crank-slider mechanism are conducted. The test results agree well with that of the finite difference method, and the maximum absolute deviation of the results is less than 3%. The proposed approach is not only convenient for automatic modeling, but also helpful for the reduction of the complexity of sensitivity analysis, which provides a practical and effective way to obtain sensitivity for the optimization problems of multibody systems.

  18. Sensitivity analysis of dynamic biological systems with time-delays.

    Science.gov (United States)

    Wu, Wu Hsiung; Wang, Feng Sheng; Chang, Maw Shang

    2010-10-15

    Mathematical modeling has been applied to the study and analysis of complex biological systems for a long time. Some processes in biological systems, such as the gene expression and feedback control in signal transduction networks, involve a time delay. These systems are represented as delay differential equation (DDE) models. Numerical sensitivity analysis of a DDE model by the direct method requires the solutions of model and sensitivity equations with time-delays. The major effort is the computation of Jacobian matrix when computing the solution of sensitivity equations. The computation of partial derivatives of complex equations either by the analytic method or by symbolic manipulation is time consuming, inconvenient, and prone to introduce human errors. To address this problem, an automatic approach to obtain the derivatives of complex functions efficiently and accurately is necessary. We have proposed an efficient algorithm with an adaptive step size control to compute the solution and dynamic sensitivities of biological systems described by ordinal differential equations (ODEs). The adaptive direct-decoupled algorithm is extended to solve the solution and dynamic sensitivities of time-delay systems describing by DDEs. To save the human effort and avoid the human errors in the computation of partial derivatives, an automatic differentiation technique is embedded in the extended algorithm to evaluate the Jacobian matrix. The extended algorithm is implemented and applied to two realistic models with time-delays: the cardiovascular control system and the TNF-α signal transduction network. The results show that the extended algorithm is a good tool for dynamic sensitivity analysis on DDE models with less user intervention. By comparing with direct-coupled methods in theory, the extended algorithm is efficient, accurate, and easy to use for end users without programming background to do dynamic sensitivity analysis on complex biological systems with time-delays.

  19. Sensitivity analysis of the fission gas behavior model in BISON.

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton; Pastore, Giovanni; Perez, Danielle; Williamson, Richard

    2013-05-01

    This report summarizes the result of a NEAMS project focused on sensitivity analysis of a new model for the fission gas behavior (release and swelling) in the BISON fuel performance code of Idaho National Laboratory. Using the new model in BISON, the sensitivity of the calculated fission gas release and swelling to the involved parameters and the associated uncertainties is investigated. The study results in a quantitative assessment of the role of intrinsic uncertainties in the analysis of fission gas behavior in nuclear fuel.

  20. Applying DEA sensitivity analysis to efficiency measurement of Vietnamese universities

    Directory of Open Access Journals (Sweden)

    Thi Thanh Huyen Nguyen

    2015-11-01

    Full Text Available The primary purpose of this study is to measure the technical efficiency of 30 doctorate-granting universities, the universities or the higher education institutes with PhD training programs, in Vietnam, applying the sensitivity analysis of data envelopment analysis (DEA. The study uses eight sets of input-output specifications using the replacement as well as aggregation/disaggregation of variables. The measurement results allow us to examine the sensitivity of the efficiency of these universities with the sets of variables. The findings also show the impact of variables on their efficiency and its “sustainability”.

  1. What Constitutes a "Good" Sensitivity Analysis? Elements and Tools for a Robust Sensitivity Analysis with Reduced Computational Cost

    Science.gov (United States)

    Razavi, Saman; Gupta, Hoshin; Haghnegahdar, Amin

    2016-04-01

    Global sensitivity analysis (GSA) is a systems theoretic approach to characterizing the overall (average) sensitivity of one or more model responses across the factor space, by attributing the variability of those responses to different controlling (but uncertain) factors (e.g., model parameters, forcings, and boundary and initial conditions). GSA can be very helpful to improve the credibility and utility of Earth and Environmental System Models (EESMs), as these models are continually growing in complexity and dimensionality with continuous advances in understanding and computing power. However, conventional approaches to GSA suffer from (1) an ambiguous characterization of sensitivity, and (2) poor computational efficiency, particularly as the problem dimension grows. Here, we identify several important sensitivity-related characteristics of response surfaces that must be considered when investigating and interpreting the ''global sensitivity'' of a model response (e.g., a metric of model performance) to its parameters/factors. Accordingly, we present a new and general sensitivity and uncertainty analysis framework, Variogram Analysis of Response Surfaces (VARS), based on an analogy to 'variogram analysis', that characterizes a comprehensive spectrum of information on sensitivity. We prove, theoretically, that Morris (derivative-based) and Sobol (variance-based) methods and their extensions are special cases of VARS, and that their SA indices are contained within the VARS framework. We also present a practical strategy for the application of VARS to real-world problems, called STAR-VARS, including a new sampling strategy, called "star-based sampling". Our results across several case studies show the STAR-VARS approach to provide reliable and stable assessments of "global" sensitivity, while being at least 1-2 orders of magnitude more efficient than the benchmark Morris and Sobol approaches.

  2. A Global Sensitivity Analysis Methodology for Multi-physics Applications

    Energy Technology Data Exchange (ETDEWEB)

    Tong, C H; Graziani, F R

    2007-02-02

    Experiments are conducted to draw inferences about an entire ensemble based on a selected number of observations. This applies to both physical experiments as well as computer experiments, the latter of which are performed by running the simulation models at different input configurations and analyzing the output responses. Computer experiments are instrumental in enabling model analyses such as uncertainty quantification and sensitivity analysis. This report focuses on a global sensitivity analysis methodology that relies on a divide-and-conquer strategy and uses intelligent computer experiments. The objective is to assess qualitatively and/or quantitatively how the variabilities of simulation output responses can be accounted for by input variabilities. We address global sensitivity analysis in three aspects: methodology, sampling/analysis strategies, and an implementation framework. The methodology consists of three major steps: (1) construct credible input ranges; (2) perform a parameter screening study; and (3) perform a quantitative sensitivity analysis on a reduced set of parameters. Once identified, research effort should be directed to the most sensitive parameters to reduce their uncertainty bounds. This process is repeated with tightened uncertainty bounds for the sensitive parameters until the output uncertainties become acceptable. To accommodate the needs of multi-physics application, this methodology should be recursively applied to individual physics modules. The methodology is also distinguished by an efficient technique for computing parameter interactions. Details for each step will be given using simple examples. Numerical results on large scale multi-physics applications will be available in another report. Computational techniques targeted for this methodology have been implemented in a software package called PSUADE.

  3. Sensitivity Analysis of a Bioinspired Refractive Index Based Gas Sensor

    Institute of Scientific and Technical Information of China (English)

    Yang Gao; Qi Xia; Guanglan Liao; Tielin Shi

    2011-01-01

    It was found out that the change of refractive index of ambient gas can lead to obvious change of the color of Morpho butterfly's wing. Such phenomenon has been employed as a sensing principle for detecting gas. In the present study, Rigorous Coupled-Wave Analysis (RCWA) was described briefly, and the partial derivative of optical reflection efficiency with respect to the refractive index of ambient gas, i.e., sensitivity of the sensor, was derived based on RCWA. A bioinspired grating model was constructed by mimicking the nanostructure on the ground scale of Morpho didius butterfly's wing. The analytical sensitivity was verified and the effect of the grating shape on the reflection spectra and its sensitivity were discussed. The results show that by tuning shape parameters of the grating, we can obtain desired reflection spectra and sensitivity, which can be applied to the design of the bioinspired refractive index based gas sensor.

  4. Structural Optimization of Slender Robot Arm Based on Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    Zhong Luo

    2012-01-01

    Full Text Available An effective structural optimization method based on a sensitivity analysis is proposed to optimize the variable section of a slender robot arm. The structure mechanism and the operating principle of a polishing robot are introduced firstly, and its stiffness model is established. Then, a design of sensitivity analysis method and a sequential linear programming (SLP strategy are developed. At the beginning of the optimization, the design sensitivity analysis method is applied to select the sensitive design variables which can make the optimized results more efficient and accurate. In addition, it can also be used to determine the scale of moving step which will improve the convergency during the optimization process. The design sensitivities are calculated using the finite difference method. The search for the final optimal structure is performed using the SLP method. Simulation results show that the proposed structure optimization method is effective in enhancing the stiffness of the robot arm regardless of the robot arm suffering either a constant force or variable forces.

  5. Shape sensitivity analysis in numerical modelling of solidification

    Directory of Open Access Journals (Sweden)

    E. Majchrzak

    2007-12-01

    Full Text Available The methods of sensitivity analysis constitute a very effective tool on the stage of numerical modelling of casting solidification. It is possible, among others, to rebuilt the basic numerical solution on the solution concerning the others disturbed values of physical and geometrical parameters of the process. In this paper the problem of shape sensitivity analysis is discussed. The non-homogeneous casting-mould domain is considered and the perturbation of the solidification process due to the changes of geometrical dimensions is analyzed. From the mathematical point of view the sensitivity model is rather complex but its solution gives the interesting information concerning the mutual connections between the kinetics of casting solidification and its basic dimensions. In the final part of the paper the example of computations is shown. On the stage of numerical realization the finite difference method has been applied.

  6. Sensitivity analysis in a Lassa fever deterministic mathematical model

    Science.gov (United States)

    Abdullahi, Mohammed Baba; Doko, Umar Chado; Mamuda, Mamman

    2015-05-01

    Lassa virus that causes the Lassa fever is on the list of potential bio-weapons agents. It was recently imported into Germany, the Netherlands, the United Kingdom and the United States as a consequence of the rapid growth of international traffic. A model with five mutually exclusive compartments related to Lassa fever is presented and the basic reproduction number analyzed. A sensitivity analysis of the deterministic model is performed. This is done in order to determine the relative importance of the model parameters to the disease transmission. The result of the sensitivity analysis shows that the most sensitive parameter is the human immigration, followed by human recovery rate, then person to person contact. This suggests that control strategies should target human immigration, effective drugs for treatment and education to reduced person to person contact.

  7. Blurring the Inputs: A Natural Language Approach to Sensitivity Analysis

    Science.gov (United States)

    Kleb, William L.; Thompson, Richard A.; Johnston, Christopher O.

    2007-01-01

    To document model parameter uncertainties and to automate sensitivity analyses for numerical simulation codes, a natural-language-based method to specify tolerances has been developed. With this new method, uncertainties are expressed in a natural manner, i.e., as one would on an engineering drawing, namely, 5.25 +/- 0.01. This approach is robust and readily adapted to various application domains because it does not rely on parsing the particular structure of input file formats. Instead, tolerances of a standard format are added to existing fields within an input file. As a demonstration of the power of this simple, natural language approach, a Monte Carlo sensitivity analysis is performed for three disparate simulation codes: fluid dynamics (LAURA), radiation (HARA), and ablation (FIAT). Effort required to harness each code for sensitivity analysis was recorded to demonstrate the generality and flexibility of this new approach.

  8. Sensitivity analysis for reliable design verification of nuclear turbosets

    Energy Technology Data Exchange (ETDEWEB)

    Zentner, Irmela, E-mail: irmela.zentner@edf.f [Lamsid-Laboratory for Mechanics of Aging Industrial Structures, UMR CNRS/EDF, 1, avenue Du General de Gaulle, 92141 Clamart (France); EDF R and D-Structural Mechanics and Acoustics Department, 1, avenue Du General de Gaulle, 92141 Clamart (France); Tarantola, Stefano [Joint Research Centre of the European Commission-Institute for Protection and Security of the Citizen, T.P. 361, 21027 Ispra (Italy); Rocquigny, E. de [Ecole Centrale Paris-Applied Mathematics and Systems Department (MAS), Grande Voie des Vignes, 92 295 Chatenay-Malabry (France)

    2011-03-15

    In this paper, we present an application of sensitivity analysis for design verification of nuclear turbosets. Before the acquisition of a turbogenerator, energy power operators perform independent design assessment in order to assure safe operating conditions of the new machine in its environment. Variables of interest are related to the vibration behaviour of the machine: its eigenfrequencies and dynamic sensitivity to unbalance. In the framework of design verification, epistemic uncertainties are preponderant. This lack of knowledge is due to inexistent or imprecise information about the design as well as to interaction of the rotating machinery with supporting and sub-structures. Sensitivity analysis enables the analyst to rank sources of uncertainty with respect to their importance and, possibly, to screen out insignificant sources of uncertainty. Further studies, if necessary, can then focus on predominant parameters. In particular, the constructor can be asked for detailed information only about the most significant parameters.

  9. Sensitivity analysis of the critical speed in railway vehicle dynamics

    Science.gov (United States)

    Bigoni, D.; True, H.; Engsig-Karup, A. P.

    2014-05-01

    We present an approach to global sensitivity analysis aiming at the reduction of its computational cost without compromising the results. The method is based on sampling methods, cubature rules, high-dimensional model representation and total sensitivity indices. It is applied to a half car with a two-axle Cooperrider bogie, in order to study the sensitivity of the critical speed with respect to the suspension parameters. The importance of a certain suspension component is expressed by the variance in critical speed that is ascribable to it. This proves to be useful in the identification of parameters for which the accuracy of their values is critically important. The approach has a general applicability in many engineering fields and does not require the knowledge of the particular solver of the dynamical system. This analysis can be used as part of the virtual homologation procedure and to help engineers during the design phase of complex systems.

  10. Thick Concrete Specimen Construction, Testing, and Preliminary Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Dwight A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hoegh, Kyle [Univ. of Minnesota, Minneapolis, MN (United States); Khazanovich, Lev [Univ. of Minnesota, Minneapolis, MN (United States)

    2015-03-01

    The purpose of the U.S. Department of Energy Office of Nuclear Energy’s Light Water Reactor Sustainability (LWRS) Program is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the operating lifetimes of nuclear power plants (NPPs) beyond 60 years. Since many important safety structures in an NPP are constructed of concrete, inspection techniques must be developed and tested to evaluate the internal condition. In-service containment structures generally do not allow for the destructive measures necessary to validate the accuracy of these inspection techniques. This creates a need for comparative testing of the various nondestructive evaluation (NDE) measurement techniques on concrete specimens with known material properties, voids, internal microstructure flaws, and reinforcement locations. A preliminary report detailed some of the challenges associated with thick reinforced concrete sections and prioritized conceptual designs of specimens that could be fabricated to represent NPP concrete structures for using in NDE evaluation comparisons. This led to the construction of the concrete specimen presented in this report, which has sufficient reinforcement density and cross-sectional size to represent an NPP containment wall. Details on how a suitably thick concrete specimen was constructed are presented, including the construction materials, final nominal design schematic, as well as formwork and rigging required to safely meet the desired dimensions of the concrete structure. The report also details the type and methods of forming the concrete specimen as well as information on how the rebar and simulated defects were embedded. Details on how the resulting specimen was transported, safely anchored, and marked to allow access for systematic comparative NDE testing of defects in a representative NPP containment wall concrete specimen are also given. Data collection using the MIRA Ultrasonic NDE equipment and

  11. Automated Sensitivity Analysis of Interplanetary Trajectories for Optimal Mission Design

    Science.gov (United States)

    Knittel, Jeremy; Hughes, Kyle; Englander, Jacob; Sarli, Bruno

    2017-01-01

    This work describes a suite of Python tools known as the Python EMTG Automated Trade Study Application (PEATSA). PEATSA was written to automate the operation of trajectory optimization software, simplify the process of performing sensitivity analysis, and was ultimately found to out-perform a human trajectory designer in unexpected ways. These benefits will be discussed and demonstrated on sample mission designs.

  12. Lower extremity angle measurement with accelerometers - error and sensitivity analysis

    NARCIS (Netherlands)

    Willemsen, Antoon Th.M.; Frigo, Carlo; Boom, Herman B.K.

    1991-01-01

    The use of accelerometers for angle assessment of the lower extremities is investigated. This method is evaluated by an error-and-sensitivity analysis using healthy subject data. Of three potential error sources (the reference system, the accelerometers, and the model assumptions) the last is found

  13. Omitted Variable Sensitivity Analysis with the Annotated Love Plot

    Science.gov (United States)

    Hansen, Ben B.; Fredrickson, Mark M.

    2014-01-01

    The goal of this research is to make sensitivity analysis accessible not only to empirical researchers but also to the various stakeholders for whom educational evaluations are conducted. To do this it derives anchors for the omitted variable (OV)-program participation association intrinsically, using the Love plot to present a wide range of…

  14. Carbon dioxide capture processes: Simulation, design and sensitivity analysis

    DEFF Research Database (Denmark)

    Zaman, Muhammad; Lee, Jay Hyung; Gani, Rafiqul

    2012-01-01

    Carbon dioxide is the main greenhouse gas and its major source is combustion of fossil fuels for power generation. The objective of this study is to carry out the steady-state sensitivity analysis for chemical absorption of carbon dioxide capture from flue gas using monoethanolamine solvent. First...

  15. Determination of temperature of moving surface by sensitivity analysis

    CERN Document Server

    Farhanieh, B

    2002-01-01

    In this paper sensitivity analysis in inverse problem solutions is employed to estimate the temperature of a moving surface. Moving finite element method is used for spatial discretization. Time derivatives are approximated using Crank-Nicklson method. The accuracy of the solution is assessed by simulation method. The convergence domain is investigated for the determination of the temperature of a solid fuel.

  16. Sensitivity analysis on parameters and processes affecting vapor intrusion risk

    NARCIS (Netherlands)

    Picone, S.; Valstar, J.R.; Gaans, van P.; Grotenhuis, J.T.C.; Rijnaarts, H.H.M.

    2012-01-01

    A one-dimensional numerical model was developed and used to identify the key processes controlling vapor intrusion risks by means of a sensitivity analysis. The model simulates the fate of a dissolved volatile organic compound present below the ventilated crawl space of a house. In contrast to the v

  17. Detecting tipping points in ecological models with sensitivity analysis

    NARCIS (Netherlands)

    Broeke, G.A. ten; Voorn, van G.A.K.; Kooi, B.W.; Molenaar, J.

    2016-01-01

    Simulation models are commonly used to understand and predict the developmentof ecological systems, for instance to study the occurrence of tipping points and their possibleecological effects. Sensitivity analysis is a key tool in the study of model responses to change s in conditions. The applicabi

  18. Detecting Tipping points in Ecological Models with Sensitivity Analysis

    NARCIS (Netherlands)

    Broeke, ten G.A.; Voorn, van G.A.K.; Kooi, B.W.; Molenaar, Jaap

    2016-01-01

    Simulation models are commonly used to understand and predict the development of ecological systems, for instance to study the occurrence of tipping points and their possible ecological effects. Sensitivity analysis is a key tool in the study of model responses to changes in conditions. The appli

  19. Methods for global sensitivity analysis in life cycle assessment

    NARCIS (Netherlands)

    Groen, Evelyne A.; Bokkers, Eddy; Heijungs, Reinout; Boer, de Imke J.M.

    2017-01-01

    Purpose: Input parameters required to quantify environmental impact in life cycle assessment (LCA) can be uncertain due to e.g. temporal variability or unknowns about the true value of emission factors. Uncertainty of environmental impact can be analysed by means of a global sensitivity analysis to

  20. Design tradeoff studies and sensitivity analysis. Appendix B

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-25

    The results of the design trade-off studies and the sensitivity analysis of Phase I of the Near Term Hybrid Vehicle (NTHV) Program are presented. The effects of variations in the design of the vehicle body, propulsion systems, and other components on vehicle power, weight, cost, and fuel economy and an optimized hybrid vehicle design are discussed. (LCL)

  1. Improvement of reflood model in RELAP5 code based on sensitivity analysis

    Energy Technology Data Exchange (ETDEWEB)

    Li, Dong; Liu, Xiaojing; Yang, Yanhua, E-mail: yanhuay@sjtu.edu.cn

    2016-07-15

    Highlights: • Sensitivity analysis is performed on the reflood model of RELAP5. • The selected influential models are discussed and modified. • The modifications are assessed by FEBA experiment and better predictions are obtained. - Abstract: Reflooding is an important and complex process to the safety of nuclear reactor during loss of coolant accident (LOCA). Accurate prediction of the reflooding behavior is one of the challenge tasks for the current system code development. RELAP5 as a widely used system code has the capability to simulate this process but with limited accuracy, especially for low inlet flow rate reflooding conditions. Through the preliminary assessment with six FEBA (Flooding Experiments with Blocked Arrays) tests, it is observed that the peak cladding temperature (PCT) is generally underestimated and bundle quench is predicted too early compared to the experiment data. In this paper, the improvement of constitutive models related to reflooding is carried out based on single parametric sensitivity analysis. Film boiling heat transfer model and interfacial friction model of dispersed flow are selected as the most influential models to the results of interests. Then studies and discussions are specifically focused on these sensitive models and proper modifications are recommended. These proposed improvements are implemented in RELAP5 code and assessed against FEBA experiment. Better agreement between calculations and measured data for both cladding temperature and quench time is obtained.

  2. A geostatistics-informed hierarchical sensitivity analysis method for complex groundwater flow and transport modeling: GEOSTATISTICAL SENSITIVITY ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Dai, Heng [Pacific Northwest National Laboratory, Richland Washington USA; Chen, Xingyuan [Pacific Northwest National Laboratory, Richland Washington USA; Ye, Ming [Department of Scientific Computing, Florida State University, Tallahassee Florida USA; Song, Xuehang [Pacific Northwest National Laboratory, Richland Washington USA; Zachara, John M. [Pacific Northwest National Laboratory, Richland Washington USA

    2017-05-01

    Sensitivity analysis is an important tool for quantifying uncertainty in the outputs of mathematical models, especially for complex systems with a high dimension of spatially correlated parameters. Variance-based global sensitivity analysis has gained popularity because it can quantify the relative contribution of uncertainty from different sources. However, its computational cost increases dramatically with the complexity of the considered model and the dimension of model parameters. In this study we developed a hierarchical sensitivity analysis method that (1) constructs an uncertainty hierarchy by analyzing the input uncertainty sources, and (2) accounts for the spatial correlation among parameters at each level of the hierarchy using geostatistical tools. The contribution of uncertainty source at each hierarchy level is measured by sensitivity indices calculated using the variance decomposition method. Using this methodology, we identified the most important uncertainty source for a dynamic groundwater flow and solute transport in model at the Department of Energy (DOE) Hanford site. The results indicate that boundary conditions and permeability field contribute the most uncertainty to the simulated head field and tracer plume, respectively. The relative contribution from each source varied spatially and temporally as driven by the dynamic interaction between groundwater and river water at the site. By using a geostatistical approach to reduce the number of realizations needed for the sensitivity analysis, the computational cost of implementing the developed method was reduced to a practically manageable level. The developed sensitivity analysis method is generally applicable to a wide range of hydrologic and environmental problems that deal with high-dimensional spatially-distributed parameters.

  3. Preliminary Analysis of Species Partitioning in the DWPF Melter

    Energy Technology Data Exchange (ETDEWEB)

    Choi, A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Kesterson, M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Johnson, F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); McCabe, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-07-15

    The work described in this report is preliminary in nature since its goal was to demonstrate the feasibility of estimating the off-gas entrainment rates from the Defense Waste Processing Facility (DWPF) melter based on a simple mass balance using measured feed and glass pour stream compositions and timeaveraged melter operating data over the duration of one canister-filling cycle. The only case considered in this study involved the SB6 pour stream sample taken while Canister #3472 was being filled over a 20-hour period on 12/20/2010, approximately three months after the bubblers were installed. The analytical results for that pour stream sample provided the necessary glass composition data for the mass balance calculations. To estimate the “matching” feed composition, which is not necessarily the same as that of the Melter Feed Tank (MFT) batch being fed at the time of pour stream sampling, a mixing model was developed involving three preceding MFT batches as well as the one being fed at that time based on the assumption of perfect mixing in the glass pool but with an induction period to account for the process delays involved in the calcination/fusion step in the cold cap and the melter turnover.

  4. Preliminary Coupling of MATRA Code for Multi-physics Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seongjin; Choi, Jinyoung; Yang, Yongsik; Kwon, Hyouk; Hwang, Daehyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The boundary conditions such as the inlet temperature, mass flux, averaged heat flux, power distributions of the rods, and core geometry is given by constant values or functions of time. These conditions are separately calculated and provided by other codes, such as a neutronics or a system codes, into the MATRA code. In addition, the coupling of several codes in the different physics field is focused and embodied. In this study, multiphysics coupling methods were developed for a subchannel code (MATRA) with neutronics codes (MASTER, DeCART) and a fuel performance code (FRAPCON-3). Preliminary evaluation results for representative sample cases are presented. The MASTER and DeCART codes provide the power distribution of the rods in the core to the MATRA code. In case of the FRAPCON-3 code, the variation of the rod diameter induced by the thermal expansion is yielded and provided. The MATRA code transfers the thermal-hydraulic conditions that each code needs. Moreover, the coupling method with each code is described.

  5. Laboratory Investigations on Estuary Salinity Mixing: Preliminary Analysis

    Directory of Open Access Journals (Sweden)

    F. H. Nuryazmeen

    2014-05-01

    Full Text Available Estuaries are bodies of water along the coasts that are formed when fresh water from rivers flows into and mixes with salt water from the ocean. The estuaries serve as a habitat to some aquatic lives, including mangroves. Human-induced activities such as dredging of shipping lanes along the bottom estuarine, the disposal of industrial wastes into the water system and shoreline development influence estuarine dynamics which include mixing process. These activities might contribute to salinity changes and further adversely affect the estuarine ecosystem. In order to study at the characteristics of the mixing between salt water (estuary and freshwater (river, a preliminary investigation had been done in the laboratory. Fresh water was released from one end of the flume and overflowing at weir at the other end. Meanwhile, salt water was represented by the red dye tracer released through a weir and intruded upstream as a gravity current. The isohalines are plotted to see the salinity patterns. Besides, to examine the spatial and temporal salinity profiles along the laboratory investigations, the plotted graphs have been made. The results show that the changes in salinity level along the flume due to mixing between fresh water and salt water. This showed typical salt-wedge estuary characteristics.

  6. Integrative "omic" analysis for tamoxifen sensitivity through cell based models.

    Directory of Open Access Journals (Sweden)

    Liming Weng

    Full Text Available It has long been observed that tamoxifen sensitivity varies among breast cancer patients. Further, ethnic differences of tamoxifen therapy between Caucasian and African American have also been reported. Since most studies have been focused on Caucasian people, we sought to comprehensively evaluate genetic variants related to tamoxifen therapy in African-derived samples. An integrative "omic" approach developed by our group was used to investigate relationships among endoxifen (an active metabolite of tamoxifen sensitivity, SNP genotype, mRNA and microRNA expressions in 58 HapMap YRI lymphoblastoid cell lines. We identified 50 SNPs that associate with cellular sensitivity to endoxifen through their effects on 34 genes and 30 microRNA expression. Some of these findings are shared in both Caucasian and African samples, while others are unique in the African samples. Among gene/microRNA that were identified in both ethnic groups, the expression of TRAF1 is also correlated with tamoxifen sensitivity in a collection of 44 breast cancer cell lines. Further, knock-down TRAF1 and over-expression of hsa-let-7i confirmed the roles of hsa-let-7i and TRAF1 in increasing tamoxifen sensitivity in the ZR-75-1 breast cancer cell line. Our integrative omic analysis facilitated the discovery of pharmacogenomic biomarkers that potentially affect tamoxifen sensitivity.

  7. Differentially Private Data Analysis of Social Networks via Restricted Sensitivity

    CERN Document Server

    Blocki, Jeremiah; Datta, Anupam; Sheffet, Or

    2012-01-01

    We introduce the notion of restricted sensitivity as an alternative to global and smooth sensitivity to improve accuracy in differentially private data analysis. The definition of restricted sensitivity is similar to that of global sensitivity except that instead of quantifying over all possible datasets, we take advantage of any beliefs about the dataset that a querier may have, to quantify over a restricted class of datasets. Specifically, given a query f and a hypothesis H about the structure of a dataset D, we show generically how to transform f into a new query f_H whose global sensitivity (over all datasets including those that do not satisfy H) matches the restricted sensitivity of the query f. Moreover, if the belief of the querier is correct (i.e., D is in H) then f_H(D) = f(D). If the belief is incorrect, then f_H(D) may be inaccurate. We demonstrate the usefulness of this notion by considering the task of answering queries regarding social-networks, which we model as a combination of a graph and a ...

  8. Fukushima Daiichi unit 1 uncertainty analysis--Preliminary selection of uncertain parameters and analysis methodology

    Energy Technology Data Exchange (ETDEWEB)

    Cardoni, Jeffrey N.; Kalinich, Donald A.

    2014-02-01

    Sandia National Laboratories (SNL) plans to conduct uncertainty analyses (UA) on the Fukushima Daiichi unit (1F1) plant with the MELCOR code. The model to be used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). However, that study only examined a handful of various model inputs and boundary conditions, and the predictions yielded only fair agreement with plant data and current release estimates. The goal of this uncertainty study is to perform a focused evaluation of uncertainty in core melt progression behavior and its effect on key figures-of-merit (e.g., hydrogen production, vessel lower head failure, etc.). In preparation for the SNL Fukushima UA work, a scoping study has been completed to identify important core melt progression parameters for the uncertainty analysis. The study also lays out a preliminary UA methodology.

  9. Early detection of breast cancer using total biochemical analysis of peripheral blood components: a preliminary study.

    Science.gov (United States)

    Zelig, Udi; Barlev, Eyal; Bar, Omri; Gross, Itai; Flomen, Felix; Mordechai, Shaul; Kapelushnik, Joseph; Nathan, Ilana; Kashtan, Hanoch; Wasserberg, Nir; Madhala-Givon, Osnat

    2015-05-15

    Most of the blood tests aiming for breast cancer screening rely on quantification of a single or few biomarkers. The aim of this study was to evaluate the feasibility of detecting breast cancer by analyzing the total biochemical composition of plasma as well as peripheral blood mononuclear cells (PBMCs) using infrared spectroscopy. Blood was collected from 29 patients with confirmed breast cancer and 30 controls with benign or no breast tumors, undergoing screening for breast cancer. PBMCs and plasma were isolated and dried on a zinc selenide slide and measured under a Fourier transform infrared (FTIR) microscope to obtain their infrared absorption spectra. Differences in the spectra of PBMCs and plasma between the groups were analyzed as well as the specific influence of the relevant pathological characteristics of the cancer patients. Several bands in the FTIR spectra of both blood components significantly distinguished patients with and without cancer. Employing feature extraction with quadratic discriminant analysis, a sensitivity of ~90 % and a specificity of ~80 % for breast cancer detection was achieved. These results were confirmed by Monte Carlo cross-validation. Further analysis of the cancer group revealed an influence of several clinical parameters, such as the involvement of lymph nodes, on the infrared spectra, with each blood component affected by different parameters. The present preliminary study suggests that FTIR spectroscopy of PBMCs and plasma is a potentially feasible and efficient tool for the early detection of breast neoplasms. An important application of our study is the distinction between benign lesions (considered as part of the non-cancer group) and malignant tumors thus reducing false positive results at screening. Furthermore, the correlation of specific spectral changes with clinical parameters of cancer patients indicates for possible contribution to diagnosis and prognosis.

  10. Nonlinear mathematical modeling and sensitivity analysis of hydraulic drive unit

    Science.gov (United States)

    Kong, Xiangdong; Yu, Bin; Quan, Lingxiao; Ba, Kaixian; Wu, Liujie

    2015-09-01

    The previous sensitivity analysis researches are not accurate enough and also have the limited reference value, because those mathematical models are relatively simple and the change of the load and the initial displacement changes of the piston are ignored, even experiment verification is not conducted. Therefore, in view of deficiencies above, a nonlinear mathematical model is established in this paper, including dynamic characteristics of servo valve, nonlinear characteristics of pressure-flow, initial displacement of servo cylinder piston and friction nonlinearity. The transfer function block diagram is built for the hydraulic drive unit closed loop position control, as well as the state equations. Through deriving the time-varying coefficient items matrix and time-varying free items matrix of sensitivity equations respectively, the expression of sensitivity equations based on the nonlinear mathematical model are obtained. According to structure parameters of hydraulic drive unit, working parameters, fluid transmission characteristics and measured friction-velocity curves, the simulation analysis of hydraulic drive unit is completed on the MATLAB/Simulink simulation platform with the displacement step 2 mm, 5 mm and 10 mm, respectively. The simulation results indicate that the developed nonlinear mathematical model is sufficient by comparing the characteristic curves of experimental step response and simulation step response under different constant load. Then, the sensitivity function time-history curves of seventeen parameters are obtained, basing on each state vector time-history curve of step response characteristic. The maximum value of displacement variation percentage and the sum of displacement variation absolute values in the sampling time are both taken as sensitivity indexes. The sensitivity indexes values above are calculated and shown visually in histograms under different working conditions, and change rules are analyzed. Then the sensitivity

  11. Preliminary Analysis of a Novel SAR Based Emergency System for Earth Orbit Satellites using Galileo

    NARCIS (Netherlands)

    Gill, E.K.A.; Helderweirt, A.

    2010-01-01

    This paper presents a preliminary analysis of a novel Search and Rescue (SAR) based emergency system for Low Earth Orbit (LEO) satellites using the Galileo Global Navigation Satellite System (GNSS). It starts with a description of the space user SAR system including a concept description, mission ar

  12. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Rosenberg, Michael I.; Wang, Weimin; Zhang, Jian; Mendon, Vrushali V.; Athalye, Rahul A.; Xie, YuLong; Hart, Reid; Goel, Supriya

    2014-03-01

    This report provides a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of ANSI/ASHRAE/IES Standard 90.1-2013 would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IES Standard 90.1-2010.

  13. Sensitivity and Uncertainty Analysis of the GFR MOX Fuel Subassembly

    Science.gov (United States)

    Lüley, J.; Vrban, B.; Čerba, Š.; Haščík, J.; Nečas, V.; Pelloni, S.

    2014-04-01

    We performed sensitivity and uncertainty analysis as well as benchmark similarity assessment of the MOX fuel subassembly designed for the Gas-Cooled Fast Reactor (GFR) as a representative material of the core. Material composition was defined for each assembly ring separately allowing us to decompose the sensitivities not only for isotopes and reactions but also for spatial regions. This approach was confirmed by direct perturbation calculations for chosen materials and isotopes. Similarity assessment identified only ten partly comparable benchmark experiments that can be utilized in the field of GFR development. Based on the determined uncertainties, we also identified main contributors to the calculation bias.

  14. Application of Sensitivity Analysis in Design of Sustainable Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per; Brohus, Henrik; Hesselholt, Allan Tind

    2007-01-01

    satisfies the design requirements and objectives. In the design of sustainable Buildings it is beneficial to identify the most important design parameters in order to develop more efficiently alternative design solutions or reach optimized design solutions. A sensitivity analysis makes it possible...... to identify the most important parameters in relation to building performance and to focus design and optimization of sustainable buildings on these fewer, but most important parameters. The sensitivity analyses will typically be performed at a reasonably early stage of the building design process, where...

  15. Rethinking Sensitivity Analysis of Nuclear Simulations with Topology

    Energy Technology Data Exchange (ETDEWEB)

    Dan Maljovec; Bei Wang; Paul Rosen; Andrea Alfonsi; Giovanni Pastore; Cristian Rabiti; Valerio Pascucci

    2016-01-01

    In nuclear engineering, understanding the safety margins of the nuclear reactor via simulations is arguably of paramount importance in predicting and preventing nuclear accidents. It is therefore crucial to perform sensitivity analysis to understand how changes in the model inputs affect the outputs. Modern nuclear simulation tools rely on numerical representations of the sensitivity information -- inherently lacking in visual encodings -- offering limited effectiveness in communicating and exploring the generated data. In this paper, we design a framework for sensitivity analysis and visualization of multidimensional nuclear simulation data using partition-based, topology-inspired regression models and report on its efficacy. We rely on the established Morse-Smale regression technique, which allows us to partition the domain into monotonic regions where easily interpretable linear models can be used to assess the influence of inputs on the output variability. The underlying computation is augmented with an intuitive and interactive visual design to effectively communicate sensitivity information to the nuclear scientists. Our framework is being deployed into the multi-purpose probabilistic risk assessment and uncertainty quantification framework RAVEN (Reactor Analysis and Virtual Control Environment). We evaluate our framework using an simulation dataset studying nuclear fuel performance.

  16. Sensitivity Analysis of a Simplified Fire Dynamic Model

    DEFF Research Database (Denmark)

    Sørensen, Lars Schiøtt; Nielsen, Anker

    2015-01-01

    This paper discusses a method for performing a sensitivity analysis of parameters used in a simplified fire model for temperature estimates in the upper smoke layer during a fire. The results from the sensitivity analysis can be used when individual parameters affecting fire safety are assessed...... are the most significant in each case. We apply the Sobol method, which is a quantitative method that gives the percentage of the total output variance that each parameter accounts for. The most important parameter is found to be the energy release rate that explains 92% of the uncertainty in the calculated...... results for the period before thermal penetration (tp) has occurred. The analysis is also done for all combinations of two parameters in order to find the combination with the largest effect. The Sobol total for pairs had the highest value for the combination of energy release rate and area of opening...

  17. Preliminary Analysis of the Oklahoma Wavefields Demonstration Dataset

    Science.gov (United States)

    Anderson, K. R.; Sweet, J. R.; Woodward, R.; Karplus, M. S.; DeShon, H. R.; Magnani, M. B.; Hayward, C.; Langston, C. A.

    2016-12-01

    In June 2016, a field crew of 50 students, faculty, industry personnel and IRIS staff deployed a total of 390 stations as part of a community seismic experiment above an active seismic lineament in north-central Oklahoma. The goals of the experiment were to test new instrumentation and deployment strategies that record the full wavefield, and to advance understanding of earthquake source processes and regional lithospheric structure. The crew deployed 363 3C 4.5Hz Generation 2 Fairfield Z-Land nodes along three seismic lines and in a seven-layer nested gradiometer array. The seismic lines spanned a region 13 km long by 5 km wide. The nested gradiometer was designed to measure the full seismic wavefield using standard frequency-wavenumber techniques and spatial wave gradients. A broadband, 18 station "Golay 3x6" array was deployed around the gradiometer and seismic lines with an aperture of approximately 5 km to collect waveform data from local and regional events. In addition, 9 infrasound stations were deployed in order to capture and identify acoustic events that might be recorded by the seismic arrays and to quantify the wind acoustic noise effect on co-located broadband stations. The variety of instrumentation used in this deployment was chosen to capture the full seismic wavefield generated by the local and regional seismicity beneath the array and the surrounding region. We present preliminary results from the data collected during the experiment. We analyze the level of signal coherence observed across the nested gradiometer and Golay array as well as array design fidelity. We report on data quality, including completeness and noise levels, for the various types of instrumentation. We also examine the performance of co-located surface and buried nodes to determine the benefits of each installation type. Finally, we present performance comparisons between co-located nodes and broadband stations and compare these results to prior wavefield/large-N deployments

  18. Preliminary analysis techniques for ring and stringer stiffened cylindrical shells

    Science.gov (United States)

    Graham, J.

    1993-03-01

    This report outlines methods of analysis for the buckling of thin-walled circumferentially and longitudinally stiffened cylindrical shells. Methods of analysis for the various failure modes are presented in one cohesive package. Where applicable, more than one method of analysis for a failure mode is presented along with standard practices. The results of this report are primarily intended for use in launch vehicle design in the elastic range. A Microsoft Excel worksheet with accompanying macros has been developed to automate the analysis procedures.

  19. A global sensitivity analysis approach for morphogenesis models

    KAUST Repository

    Boas, Sonja E. M.

    2015-11-21

    Background Morphogenesis is a developmental process in which cells organize into shapes and patterns. Complex, non-linear and multi-factorial models with images as output are commonly used to study morphogenesis. It is difficult to understand the relation between the uncertainty in the input and the output of such ‘black-box’ models, giving rise to the need for sensitivity analysis tools. In this paper, we introduce a workflow for a global sensitivity analysis approach to study the impact of single parameters and the interactions between them on the output of morphogenesis models. Results To demonstrate the workflow, we used a published, well-studied model of vascular morphogenesis. The parameters of this cellular Potts model (CPM) represent cell properties and behaviors that drive the mechanisms of angiogenic sprouting. The global sensitivity analysis correctly identified the dominant parameters in the model, consistent with previous studies. Additionally, the analysis provided information on the relative impact of single parameters and of interactions between them. This is very relevant because interactions of parameters impede the experimental verification of the predicted effect of single parameters. The parameter interactions, although of low impact, provided also new insights in the mechanisms of in silico sprouting. Finally, the analysis indicated that the model could be reduced by one parameter. Conclusions We propose global sensitivity analysis as an alternative approach to study the mechanisms of morphogenesis. Comparison of the ranking of the impact of the model parameters to knowledge derived from experimental data and from manipulation experiments can help to falsify models and to find the operand mechanisms in morphogenesis. The workflow is applicable to all ‘black-box’ models, including high-throughput in vitro models in which output measures are affected by a set of experimental perturbations.

  20. High order sensitivity analysis of complex, coupled systems

    Science.gov (United States)

    Sobieszczanski-Sobieski, Jaroslaw

    1990-01-01

    The Sobieszczanski-Sobieski (1988) algorithm is extended to include second- and higher-order derivatives while retaining the obviation of finite-differencing of the system analysis. This is accomplished by means of a recursive application of the same implicit function theorem as in the original algorithm. In optimization, the computational cost of the higher-order derivatives is relative to the aggregate cost of analysis together with a repetition of the first-order sensitivity analysis as often as is required to produce the equivalent information by successive linearizations within move limits.

  1. Efficient sensitivity analysis and optimization of a helicopter rotor

    Science.gov (United States)

    Lim, Joon W.; Chopra, Inderjit

    1989-01-01

    Aeroelastic optimization of a system essentially consists of the determination of the optimum values of design variables which minimize the objective function and satisfy certain aeroelastic and geometric constraints. The process of aeroelastic optimization analysis is illustrated. To carry out aeroelastic optimization effectively, one needs a reliable analysis procedure to determine steady response and stability of a rotor system in forward flight. The rotor dynamic analysis used in the present study developed inhouse at the University of Maryland is based on finite elements in space and time. The analysis consists of two major phases: vehicle trim and rotor steady response (coupled trim analysis), and aeroelastic stability of the blade. For a reduction of helicopter vibration, the optimization process requires the sensitivity derivatives of the objective function and aeroelastic stability constraints. For this, the derivatives of steady response, hub loads and blade stability roots are calculated using a direct analytical approach. An automated optimization procedure is developed by coupling the rotor dynamic analysis, design sensitivity analysis and constrained optimization code CONMIN.

  2. Preliminary Design and Analysis of ITER In-Wall Shielding

    Institute of Scientific and Technical Information of China (English)

    LIU Changle; YU Jie; WU Songtao; CAI Yingxiang; PAN Wanjiang

    2007-01-01

    ITER in-wall shielding (IIS) is situated between the doubled shells of the ITER Vacuum Vessel (IVV). Its main functions are applied in shielding neutron, gamma-ray and toroidal field ripple reduction. The structure of IIS has been modelled according to the IVV design criteria which has been updated by the ITER team (IT). Static analysis and thermal expansion analysis were performed for the structure. Thermal-hydraulic analysis verified the heat removal capability and resulting temperature, pressure, and velocity changes in the coolant flow. Consequently, our design work is possibly suitable as a reference for IT's updated or final design in its next step.

  3. Preliminary Technical Risk Analysis for the Geothermal Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-01-18

    This report explains the goals, methods, and results of a probabilistic analysis of technical risk for a portfolio of R&D projects in the DOE Geothermal Technologies Program (The Program). The analysis is a task by Princeton Energy Resources International, LLC, in support of the National Renewable Energy Laboratory on behalf of the Program. The main challenge in the analysis lies in translating R&D results to a quantitative reflection of technical risk for a key Program metric: levelized cost of energy (LCOE).

  4. First fungal genome sequence from Africa: A preliminary analysis

    Directory of Open Access Journals (Sweden)

    Rene Sutherland

    2012-01-01

    Full Text Available Some of the most significant breakthroughs in the biological sciences this century will emerge from the development of next generation sequencing technologies. The ease of availability of DNA sequence made possible through these new technologies has given researchers opportunities to study organisms in a manner that was not possible with Sanger sequencing. Scientists will, therefore, need to embrace genomics, as well as develop and nurture the human capacity to sequence genomes and utilise the ’tsunami‘ of data that emerge from genome sequencing. In response to these challenges, we sequenced the genome of Fusarium circinatum, a fungal pathogen of pine that causes pitch canker, a disease of great concern to the South African forestry industry. The sequencing work was conducted in South Africa, making F. circinatum the first eukaryotic organism for which the complete genome has been sequenced locally. Here we report on the process that was followed to sequence, assemble and perform a preliminary characterisation of the genome. Furthermore, details of the computer annotation and manual curation of this genome are presented. The F. circinatum genome was found to be nearly 44 million bases in size, which is similar to that of four other Fusarium genomes that have been sequenced elsewhere. The genome contains just over 15 000 open reading frames, which is less than that of the related species, Fusarium oxysporum, but more than that for Fusarium verticillioides. Amongst the various putative gene clusters identified in F. circinatum, those encoding the secondary metabolites fumosin and fusarin appeared to harbour evidence of gene translocation. It is anticipated that similar comparisons of other loci will provide insights into the genetic basis for pathogenicity of the pitch canker pathogen. Perhaps more importantly, this project has engaged a relatively large group of scientists

  5. Sensitivity analysis of influencing parameters in cavern stability

    Institute of Scientific and Technical Information of China (English)

    Abolfazl Abdollahipour; Reza Rahmannejad

    2012-01-01

    In order to analyze the stability of the underground rock structures,knowing the sensitivity of geomechanical parameters is important.To investigate the priority of these geomechanical properties in the stability of cavern,a sensitivity analysis has been performed on a single cavern in various rock mass qualities according to RMR using Phase 2.The stability of cavern has been studied by investigating the side wall deformation.Results showed that most sensitive properties are coefficient of lateral stress and modulus of deformation.Also parameters of Hoek-Brown criterion and σc have no sensitivity when cavern is in a perfect elastic state.But in an elasto-plastic state,parameters of Hoek-Brown criterion and σc affect the deformability; such effect becomes more remarkable with increasing plastic area.Other parameters have different sensitivities concerning rock mass quality (RMR).Results have been used to propose the best set of parameters for study on prediction of sidewall displacement.

  6. Performance analysis tool (PATO): Development and preliminary validation

    National Research Council Canada - National Science Library

    Fernando Martins; Filipe Clemente; Frutuoso Silva

    2017-01-01

    .... The Performance Analysis Tool (PATO) software was built with the aim to quickly codify relationships between players and built the adjacency matrices that can be used to test the network measures...

  7. Preliminary Technical Risk Analysis for the Geothermal Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    McVeigh, J.; Cohen, J.; Vorum, M.; Porro, G.; Nix, G.

    2007-03-01

    This report explains the goals, methods, and results of a probabilistic analysis of technical risk for a portfolio of R&D projects in the DOE Geothermal Technologies Program ('the Program'). The analysis is a task by Princeton Energy Resources International, LLC (PERI), in support of the National Renewable Energy Laboratory (NREL) on behalf of the Program. The main challenge in the analysis lies in translating R&D results to a quantitative reflection of technical risk for a key Program metric: levelized cost of energy (LCOE). This requires both computational development (i.e., creating a spreadsheet-based analysis tool) and a synthesis of judgments by a panel of researchers and experts of the expected results of the Program's R&D.

  8. Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.

    Science.gov (United States)

    Fries, G R; Quevedo, J; Zeni, C P; Kazimi, I F; Zunta-Soares, G; Spiker, D E; Bowden, C L; Walss-Bass, C; Soares, J C

    2017-03-14

    First-degree relatives of patients with bipolar disorder (BD), particularly their offspring, have a higher risk of developing BD and other mental illnesses than the general population. However, the biological mechanisms underlying this increased risk are still unknown, particularly because most of the studies so far have been conducted in chronically ill adults and not in unaffected youth at high risk. In this preliminary study we analyzed genome-wide expression and methylation levels in peripheral blood mononuclear cells from children and adolescents from three matched groups: BD patients, unaffected offspring of bipolar parents (high risk) and controls (low risk). By integrating gene expression and DNA methylation and comparing the lists of differentially expressed genes and differentially methylated probes between groups, we were able to identify 43 risk genes that discriminate patients and high-risk youth from controls. Pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for BD in vulnerable populations. Cell-based assays indicate a GR hyporesponsiveness in cells from adult BD patients compared to controls and suggest that these GR-related genes can be modulated by DNA methylation, which poses the theoretical possibility of manipulating their expression as a means to counteract the familial risk presented by those subjects. Although preliminary, our results suggest the utility of peripheral measures in the identification of biomarkers of risk in high-risk populations and further emphasize the potential role of stress and DNA methylation in the risk for BD in youth.

  9. An overview of the design and analysis of simulation experiments for sensitivity analysis

    NARCIS (Netherlands)

    Kleijnen, J.P.C.

    2005-01-01

    Sensitivity analysis may serve validation, optimization, and risk analysis of simulation models. This review surveys 'classic' and 'modern' designs for experiments with simulation models. Classic designs were developed for real, non-simulated systems in agriculture, engineering, etc. These designs

  10. The Methods of Sensitivity Analysis and Their Usage for Analysis of Multicriteria Decision

    Directory of Open Access Journals (Sweden)

    Rūta Simanavičienė

    2011-08-01

    Full Text Available In this paper we describe the application's fields of the sensitivity analysis methods. We pass in review the application of these methods in multiple criteria decision making, when the initial data are numbers. We formulate the problem, which of the sensitivity analysis methods is more effective for the usage in the decision making process.Article in Lithuanian

  11. Interactive Building Design Space Exploration Using Regionalized Sensitivity Analysis

    DEFF Research Database (Denmark)

    Jensen, Rasmus Lund; Maagaard, Steffen; Østergård, Torben

    2017-01-01

    Monte Carlo simulations combined with regionalized sensitivity analysis provide the means to explore a vast, multivariate design space in building design. Typically, sensitivity analysis shows how the variability of model output relates to the uncertainties in models inputs. This reveals which...... in combination with the interactive parallel coordinate plot (PCP). The latter is an effective tool to explore stochastic simulations and to find high-performing building designs. The proposed methods help decision makers to focus their attention to the most important design parameters when exploring...... a multivariate design space. As case study, we consider building performance simulations of a 15.000 m² educational centre with respect to energy demand, thermal comfort, and daylight....

  12. An analytic method for sensitivity analysis of complex systems

    CERN Document Server

    Zhu, Yueying; Li, Wei; Cai, Xu

    2016-01-01

    Sensitivity analysis is concerned with understanding how the model output depends on uncertainties (variances) in inputs and then identifies which inputs are important in contributing to the prediction imprecision. Uncertainty determination in output is the most crucial step in sensitivity analysis. In the present paper, an analytic expression, which can exactly evaluate the uncertainty in output as a function of the output's derivatives and inputs' central moments, is firstly deduced for general multivariate models with given relationship between output and inputs in terms of Taylor series expansion. A $\\gamma$-order relative uncertainty for output, denoted by $\\mathrm{R^{\\gamma}_v}$, is introduced to quantify the contributions of input uncertainty of different orders. On this basis, it is shown that the widely used approximation considering the first order contribution from the variance of input variable can satisfactorily express the output uncertainty only when the input variance is very small or the inpu...

  13. Sensitivity analysis techniques for models of human behavior.

    Energy Technology Data Exchange (ETDEWEB)

    Bier, Asmeret Brooke

    2010-09-01

    Human and social modeling has emerged as an important research area at Sandia National Laboratories due to its potential to improve national defense-related decision-making in the presence of uncertainty. To learn about which sensitivity analysis techniques are most suitable for models of human behavior, different promising methods were applied to an example model, tested, and compared. The example model simulates cognitive, behavioral, and social processes and interactions, and involves substantial nonlinearity, uncertainty, and variability. Results showed that some sensitivity analysis methods create similar results, and can thus be considered redundant. However, other methods, such as global methods that consider interactions between inputs, can generate insight not gained from traditional methods.

  14. Objective analysis of the ARM IOP data: method and sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Cedarwall, R; Lin, J L; Xie, S C; Yio, J J; Zhang, M H

    1999-04-01

    Motivated by the need of to obtain accurate objective analysis of field experimental data to force physical parameterizations in numerical models, this paper -first reviews the existing objective analysis methods and interpolation schemes that are used to derive atmospheric wind divergence, vertical velocity, and advective tendencies. Advantages and disadvantages of each method are discussed. It is shown that considerable uncertainties in the analyzed products can result from the use of different analysis schemes and even more from different implementations of a particular scheme. The paper then describes a hybrid approach to combine the strengths of the regular grid method and the line-integral method, together with a variational constraining procedure for the analysis of field experimental data. In addition to the use of upper air data, measurements at the surface and at the top-of-the-atmosphere are used to constrain the upper air analysis to conserve column-integrated mass, water, energy, and momentum. Analyses are shown for measurements taken in the Atmospheric Radiation Measurement Programs (ARM) July 1995 Intensive Observational Period (IOP). Sensitivity experiments are carried out to test the robustness of the analyzed data and to reveal the uncertainties in the analysis. It is shown that the variational constraining process significantly reduces the sensitivity of the final data products.

  15. A Sensitivity Analysis on Component Reliability from Fatigue Life Computations

    Science.gov (United States)

    1992-02-01

    AD-A247 430 MTL TR 92-5 AD A SENSITIVITY ANALYSIS ON COMPONENT RELIABILITY FROM FATIGUE LIFE COMPUTATIONS DONALD M. NEAL, WILLIAM T. MATTHEWS, MARK G...HAGI OR GHANI NUMBI:H(s) Donald M. Neal, William T. Matthews, Mark G. Vangel, and Trevor Rudalevige 9. PERFORMING ORGANIZATION NAME AND ADDRESS lU...Technical Information Center, Cameron Station, Building 5, 5010 Duke Street, Alexandria, VA 22304-6145 2 ATTN: DTIC-FDAC I MIAC/ CINDAS , Purdue

  16. Bioelectrical impedance analysis for bovine milk: Preliminary results

    Science.gov (United States)

    Bertemes-Filho, P.; Valicheski, R.; Pereira, R. M.; Paterno, A. S.

    2010-04-01

    This work reports the investigation and analysis of bovine milk quality by using biological impedance measurements using electrical impedance spectroscopy (EIS). The samples were distinguished by a first chemical analysis using Fourier transform midinfrared spectroscopy (FTIR) and flow citometry. A set of milk samples (100ml each) obtained from 17 different cows in lactation with and without mastitis were analyzed with the proposed technique using EIS. The samples were adulterated by adding distilled water and hydrogen peroxide in a controlled manner. FTIR spectroscopy and flow cytometry were performed, and impedance measurements were made in a frequency range from 500Hz up to 1MHz with an implemented EIS system. The system's phase shift was compensated by measuring saline solutions. It was possible to show that the results obtained with the Bioelectrical Impedance Analysis (BIA) technique may detect changes in the milk caused by mastitis and the presence of water and hydrogen peroxide in the bovine milk.

  17. Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy

    Science.gov (United States)

    Crameri, Aureliano; von Wyl, Agnes; Koemeda, Margit; Schulthess, Peter; Tschuschke, Volker

    2015-01-01

    The importance of preventing and treating incomplete data in effectiveness studies is nowadays emphasized. However, most of the publications focus on randomized clinical trials (RCT). One flexible technique for statistical inference with missing data is multiple imputation (MI). Since methods such as MI rely on the assumption of missing data being at random (MAR), a sensitivity analysis for testing the robustness against departures from this assumption is required. In this paper we present a sensitivity analysis technique based on posterior predictive checking, which takes into consideration the concept of clinical significance used in the evaluation of intra-individual changes. We demonstrate the possibilities this technique can offer with the example of irregular longitudinal data collected with the Outcome Questionnaire-45 (OQ-45) and the Helping Alliance Questionnaire (HAQ) in a sample of 260 outpatients. The sensitivity analysis can be used to (1) quantify the degree of bias introduced by missing not at random data (MNAR) in a worst reasonable case scenario, (2) compare the performance of different analysis methods for dealing with missing data, or (3) detect the influence of possible violations to the model assumptions (e.g., lack of normality). Moreover, our analysis showed that ratings from the patient's and therapist's version of the HAQ could significantly improve the predictive value of the routine outcome monitoring based on the OQ-45. Since analysis dropouts always occur, repeated measurements with the OQ-45 and the HAQ analyzed with MI are useful to improve the accuracy of outcome estimates in quality assurance assessments and non-randomized effectiveness studies in the field of outpatient psychotherapy. PMID:26283989

  18. A Preliminary Analysis of a Behavioral Classrooms Needs Assessment

    Science.gov (United States)

    Leaf, Justin B.; Leaf, Ronald; McCray, Cynthia; Lamkins, Carol; Taubman, Mitchell; McEachin, John; Cihon, Joseph H.

    2016-01-01

    Today many special education classrooms implement procedures based upon the principles of Applied Behavior Analysis (ABA) to establish educationally relevant skills and decrease aberrant behaviors. However, it is difficult for school staff and consultants to evaluate the implementation of various components of ABA and general classroom set up. In…

  19. A Preliminary MANPRINT Evaluation of the All Source Analysis (ASAS)

    Science.gov (United States)

    1988-11-01

    Rear (CEWI) FSIC ............................ 2 CEWI ( TCAE ) AIM(6) ........................... 2 DTOC AIM(6...Sensors and the Ml Battalion TCAE ..... ............... . 13 2. Ratings of Understanding of Tasks Required at the Completion of Training and at the...for transmission to the sensors and jammers. CEWI Tactical Control and Analysis Element ( TCAE ) AIM(6) The AIM module consists of a VAX 750R computer

  20. On the variational data assimilation problem solving and sensitivity analysis

    Science.gov (United States)

    Arcucci, Rossella; D'Amore, Luisa; Pistoia, Jenny; Toumi, Ralf; Murli, Almerico

    2017-04-01

    We consider the Variational Data Assimilation (VarDA) problem in an operational framework, namely, as it results when it is employed for the analysis of temperature and salinity variations of data collected in closed and semi closed seas. We present a computing approach to solve the main computational kernel at the heart of the VarDA problem, which outperforms the technique nowadays employed by the oceanographic operative software. The new approach is obtained by means of Tikhonov regularization. We provide the sensitivity analysis of this approach and we also study its performance in terms of the accuracy gain on the computed solution. We provide validations on two realistic oceanographic data sets.

  1. Probability and sensitivity analysis of machine foundation and soil interaction

    Directory of Open Access Journals (Sweden)

    Králik J., jr.

    2009-06-01

    Full Text Available This paper deals with the possibility of the sensitivity and probabilistic analysis of the reliability of the machine foundation depending on variability of the soil stiffness, structure geometry and compressor operation. The requirements to design of the foundation under rotating machines increased due to development of calculation method and computer tools. During the structural design process, an engineer has to consider problems of the soil-foundation and foundation-machine interaction from the safety, reliability and durability of structure point of view. The advantages and disadvantages of the deterministic and probabilistic analysis of the machine foundation resistance are discussed. The sensitivity of the machine foundation to the uncertainties of the soil properties due to longtime rotating movement of machine is not negligible for design engineers. On the example of compressor foundation and turbine fy. SIEMENS AG the affectivity of the probabilistic design methodology was presented. The Latin Hypercube Sampling (LHS simulation method for the analysis of the compressor foundation reliability was used on program ANSYS. The 200 simulations for five load cases were calculated in the real time on PC. The probabilistic analysis gives us more complex information about the soil-foundation-machine interaction as the deterministic analysis.

  2. Preliminary shielding analysis for the CSNS target station monolith

    Institute of Scientific and Technical Information of China (English)

    张斌; 陈义学; 杨寿海; 吴军; 殷雯; 梁天骄; 贾学军

    2010-01-01

    The construction of the China Spallation Neutron Source (CSNS) has been initiated at Dongguan,Guangdong,China.In spallation neutron sources the target station monolith is contaminated by a large number of fast neutrons whose energies can be as large as those of the protons of the proton beam directed towards the tungsten target.A detailed radiation transport analysis of the target station monolith is important for the construction of the CSNS.The analysis is performed using the coupled Monte Carlo and multi-dimensional discrete ordinates method.Successful elimination of the primary ray effects via the two-dimensional uncollided flux and first collision source methodology is also illustrated.The dose at the edge of the monolith is calculated.The results demonstrate that the doses received by the hall staff members are below the required standard limit.

  3. Preliminary analysis of productivity of fruiting fungi on Strzeleckie meadows

    Directory of Open Access Journals (Sweden)

    Barbara Sadowska

    2014-11-01

    Full Text Available Analysis demonstrated that the fresh ahd dry weight as well as the ash content of fungal fruit bodies collected on a forest-surrounded unmown meadow (Stellario-Deschampsietum Freitag 1957 and Caricetum elatae W.Koch 1926 were lower than the same values for a plot of exploited mown meadow and higher than on an exploited unmown meadow (Arrhenatheretum medioeuropaeum (Br.-Bl. Oberd. 1952.

  4. SAMPSON Parallel Computation for Sensitivity Analysis of TEPCO's Fukushima Daiichi Nuclear Power Plant Accident

    Science.gov (United States)

    Pellegrini, M.; Bautista Gomez, L.; Maruyama, N.; Naitoh, M.; Matsuoka, S.; Cappello, F.

    2014-06-01

    On March 11th 2011 a high magnitude earthquake and consequent tsunami struck the east coast of Japan, resulting in a nuclear accident unprecedented in time and extents. After scram started at all power stations affected by the earthquake, diesel generators began operation as designed until tsunami waves reached the power plants located on the east coast. This had a catastrophic impact on the availability of plant safety systems at TEPCO's Fukushima Daiichi, leading to the condition of station black-out from unit 1 to 3. In this article the accident scenario is studied with the SAMPSON code. SAMPSON is a severe accident computer code composed of hierarchical modules to account for the diverse physics involved in the various phases of the accident evolution. A preliminary parallelization analysis of the code was performed using state-of-the-art tools and we demonstrate how this work can be beneficial to the nuclear safety analysis. This paper shows that inter-module parallelization can reduce the time to solution by more than 20%. Furthermore, the parallel code was applied to a sensitivity study for the alternative water injection into TEPCO's Fukushima Daiichi unit 3. Results show that the core melting progression is extremely sensitive to the amount and timing of water injection, resulting in a high probability of partial core melting for unit 3.

  5. Preliminary analysis of knee stress in Full Extension Landing

    Directory of Open Access Journals (Sweden)

    Majid Davoodi Makinejad

    2013-09-01

    Full Text Available OBJECTIVE: This study provides an experimental and finite element analysis of knee-joint structure during extended-knee landing based on the extracted impact force, and it numerically identifies the contact pressure, stress distribution and possibility of bone-to-bone contact when a subject lands from a safe height. METHODS: The impact time and loads were measured via inverse dynamic analysis of free landing without knee flexion from three different heights (25, 50 and 75 cm, using five subjects with an average body mass index of 18.8. Three-dimensional data were developed from computed tomography scans and were reprocessed with modeling software before being imported and analyzed by finite element analysis software. The whole leg was considered to be a fixed middle-hinged structure, while impact loads were applied to the femur in an upward direction. RESULTS: Straight landing exerted an enormous amount of pressure on the knee joint as a result of the body's inability to utilize the lower extremity muscles, thereby maximizing the threat of injury when the load exceeds the height-safety threshold. CONCLUSIONS: The researchers conclude that extended-knee landing results in serious deformation of the meniscus and cartilage and increases the risk of bone-to-bone contact and serious knee injury when the load exceeds the threshold safety height. This risk is considerably greater than the risk of injury associated with walking downhill or flexion landing activities.

  6. Maternal Sensitivity in Parenting Preterm Children: A Meta-analysis.

    Science.gov (United States)

    Bilgin, Ayten; Wolke, Dieter

    2015-07-01

    Preterm birth is a significant stressor for parents and may adversely impact maternal parenting behavior. However, findings have been inconsistent. The objective of this meta-analysis was to determine whether mothers of preterm children behave differently (eg, less responsive or sensitive) in their interactions with their children after they are discharged from the hospital than mothers of term children. Medline, PsychInfo, ERIC, PubMed, and Web of Science were searched from January 1980 through May 2014 with the following keywords: "premature", "preterm", "low birth weight" in conjunction with "maternal behavio*r", "mother-infant interaction", "maternal sensitivity", and "parenting". Both longitudinal and cross-sectional studies that used an observational measure of maternal parenting behavior were eligible. Study results relating to parenting behaviors defined as sensitivity, facilitation, and responsivity were extracted, and mean estimates were combined with random-effects meta-analysis. Thirty-four studies were included in the meta-analysis. Mothers of preterm and full-term children did not differ significantly from each other in terms of their behavior toward their children (Hedges' g = -0.07; 95% confidence interval: -0.22 to 0.08; z = -0.94; P = .35). The heterogeneity between studies was significant and high (Q = 156.42; I(2) = 78.9, P = .001) and not explained by degree of prematurity, publication date, geographical area, infant age, or type of maternal behavior. Mothers of preterm children were not found to be less sensitive or responsive toward their children than mothers of full-term children. Copyright © 2015 by the American Academy of Pediatrics.

  7. Sensitivity analysis of fine sediment models using heterogeneous data

    Science.gov (United States)

    Kamel, A. M. Yousif; Bhattacharya, B.; El Serafy, G. Y.; van Kessel, T.; Solomatine, D. P.

    2012-04-01

    Sediments play an important role in many aquatic systems. Their transportation and deposition has significant implication on morphology, navigability and water quality. Understanding the dynamics of sediment transportation in time and space is therefore important in drawing interventions and making management decisions. This research is related to the fine sediment dynamics in the Dutch coastal zone, which is subject to human interference through constructions, fishing, navigation, sand mining, etc. These activities do affect the natural flow of sediments and sometimes lead to environmental concerns or affect the siltation rates in harbours and fairways. Numerical models are widely used in studying fine sediment processes. Accuracy of numerical models depends upon the estimation of model parameters through calibration. Studying the model uncertainty related to these parameters is important in improving the spatio-temporal prediction of suspended particulate matter (SPM) concentrations, and determining the limits of their accuracy. This research deals with the analysis of a 3D numerical model of North Sea covering the Dutch coast using the Delft3D modelling tool (developed at Deltares, The Netherlands). The methodology in this research was divided into three main phases. The first phase focused on analysing the performance of the numerical model in simulating SPM concentrations near the Dutch coast by comparing the model predictions with SPM concentrations estimated from NASA's MODIS sensors at different time scales. The second phase focused on carrying out a sensitivity analysis of model parameters. Four model parameters were identified for the uncertainty and sensitivity analysis: the sedimentation velocity, the critical shear stress above which re-suspension occurs, the shields shear stress for re-suspension pick-up, and the re-suspension pick-up factor. By adopting different values of these parameters the numerical model was run and a comparison between the

  8. Sensitivity Analysis for DHRS Heat Exchanger Performance Tests of PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Jonggan; Eoh, Jaehyuk; Kim, Dehee; Lee, Taeho; Jeong, Jiyoung [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    The STELLA-1 facility has been constructed and separate effect tests of heat exchangers for DHRS are going to be conducted. Two kinds of heat exchangers including DHX (shell-and-tube sodium-to-sodium heat exchanger) and AHX (helical-tube sodium-to-air heat exchanger) will be tested for design codes V and V. Main test points are a design point and a plant normal operation point of each heat exchanger. Additionally, some plant transient conditions are taken into account for establishing a test condition set. To choose the plant transient test conditions, a sensitivity analysis has been conducted using the design codes for each heat exchanger. The sensitivity of the PGSFR DHRS heat exchanger tests (the DHX and AHX in the STELLA-1 facility) has been analyzed through a parametric study using the design codes SHXSA and AHXSA at the design point and the plant normal operation point. The DHX heat transfer performance was sensitive to the change in the inlet temperature of the shell-side and the AHX heat transfer performance was sensitive to the change in the inlet temperature of the tube side. The results of this work will contribute to an improvement of the test matrix for the separate effect test of each heat exchanger.

  9. Preliminary analysis of the mitochondrial genome evolutionary pattern in primates

    Institute of Scientific and Technical Information of China (English)

    Liang ZHAO; Xingtao ZHANG; Xingkui TAO; Weiwei WANG; Ming LI

    2012-01-01

    Since the birth of molecular evolutionary analysis,primates have been a central focus of study and mitochondrial DNA is well suited to these endeavors because of its unique features.Surprisingly,to date no comprehensive evaluation of the nucleotide substitution patterns has been conducted on the mitochondrial genome of primates.Here,we analyzed the evolutionary patterns and evaluated selection and recombination in the mitochondrial genomes of 44 Primates species downloaded from GenBank.The results revealed that a strong rate heterogeneity occurred among sites and genes in all comparisons.Likewise,an obvious decline in primate nucleotide diversity was noted in the subunit rRNAs and tRNAs as compared to the protein-coding genes.Within 13 protein-coding genes,the pattern of nonsynonymous divergence was similar to that of overall nucleotide divergence,while synonymous changes differed only for individual genes,indicating that the rate heterogeneity may result from the rate of change at nonsynonymous sites.Codon usage analysis revealed that there was intermediate codon usage bias in primate protein-coding genes,and supported the idea that GC mutation pressure might determine codon usage and that positive selection is not the driving force for the codon usage bias.Neutrality tests using site-specific positive selection from a Bayesian framework indicated no sites were under positive selection for any gene,consistent with near neutrality.Recombination tests based on the pairwise homoplasy test statistic supported complete linkage even for much older divergent primate species.Thus,with the exception of rate heterogeneity among mitochondrial genes,evaluating the validity assumed complete linkage and selective neutrality in primates prior to phylogenetic or phylogeographic analysis seems unnecessary.

  10. Preliminary analysis of the mitochondrial genome evolutionary pattern in primates.

    Science.gov (United States)

    Zhao, Liang; Zhang, Xingtao; Tao, Xingkui; Wang, Weiwei; Li, Ming

    2012-08-01

    Since the birth of molecular evolutionary analysis, primates have been a central focus of study and mitochondrial DNA is well suited to these endeavors because of its unique features. Surprisingly, to date no comprehensive evaluation of the nucleotide substitution patterns has been conducted on the mitochondrial genome of primates. Here, we analyzed the evolutionary patterns and evaluated selection and recombination in the mitochondrial genomes of 44 Primates species downloaded from GenBank. The results revealed that a strong rate heterogeneity occurred among sites and genes in all comparisons. Likewise, an obvious decline in primate nucleotide diversity was noted in the subunit rRNAs and tRNAs as compared to the protein-coding genes. Within 13 protein-coding genes, the pattern of nonsynonymous divergence was similar to that of overall nucleotide divergence, while synonymous changes differed only for individual genes, indicating that the rate heterogeneity may result from the rate of change at nonsynonymous sites. Codon usage analysis revealed that there was intermediate codon usage bias in primate protein-coding genes, and supported the idea that GC mutation pressure might determine codon usage and that positive selection is not the driving force for the codon usage bias. Neutrality tests using site-specific positive selection from a Bayesian framework indicated no sites were under positive selection for any gene, consistent with near neutrality. Recombination tests based on the pairwise homoplasy test statistic supported complete linkage even for much older divergent primate species. Thus, with the exception of rate heterogeneity among mitochondrial genes, evaluating the validity assumed complete linkage and selective neutrality in primates prior to phylogenetic or phylogeographic analysis seems unnecessary.

  11. Preliminary safety analysis for key design features of KALIMER-600

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. B.; Chang, W. P.; Suk, S. D.; Ha, K. S.; Jeong, H. Y.; Heo, S

    2004-03-01

    KAERI is developing the conceptual design of a Liquid Metal Reactor, KALIMER-600 (Korea Advanced LIquid MEtal Reactor) under the Long-term Nuclear R and D Program. KALIMER-600 addresses key issues regarding future nuclear power plants such as plant safety, economics, proliferation, and waste. In this report, key safety design features are described and safety analyses results for typical ATWS accidents in the KALIMER design with breakeven core are presented. First, the basic approach to achieve the safety goal is introduced in Chapter 1, and the event categorization and acceptance criteria for the KALIMER-600 safety analysis are described in Chapter 2. In Chapter 3, results of inherent safety evaluations for the KALIMER-600 conceptual design are presented. The KALIMER-600 core and plant system are designed to assure benign performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated Anticipated Transient Without Scram (ATWS) have been performed using the SSC-K code to investigate the KALIMER-600 system response to the events. They are categorized as Bounding Events (BEs) because of their low probability of occurrence. In Chapter 4, the analysis of flow blockage for KALIMER-600 with the MATRA-LMR-FB code, which has been developed for the internal flow blockage in a LMR subassembly. The cases with a blockage of 6-subchannel, 24-subchannel, and 54-subchannel are analyzed.The performance analysis of the KALIMER-600 containment and some evaluations for the behaviors during HCDA will be performed later.

  12. Preliminary safety analysis for key design features of KALIMER

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, D. H.; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, S. O.; Lee, Y. B.; Jeong, K. S

    2000-07-01

    KAERI is currently developing the conceptual design of a liquid metal reactor, KALIMER(Korea Advanced Liquid Metal Reactor) under the long-term nuclear R and D program. In this report, descriptions of the KALIMER safety design features and safety analyses results for selected ATWS accidents are presented. First, the basic approach to achieve the safety goal is introduced in chapter 1, and the safety evaluation procedure for the KALIMER design is described in chapter 2. It includes event selection, event categorization, description of design basis events, and beyond design basis events. In chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. The KALIMER core and plant system are designed to assure design performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated anticipated transient without scram(ATWS) have been performed to investigate the KALIMER system response to the events. They are categorized as bounding events(BEs) because of their low probability of occurrence. In chapter 4, the design of the KALIMER containment dome and the results of its performance analysis are presented. The designs of the existing LMR containment and the KALIMER containment dome have been compared in this chapter. Procedure of the containment performance analysis and the analysis results are described along with the accident scenario and source terms. Finally, a simple methodology is introduced to investigate the core kinetics and hydraulic behavior during HCDA in chapter 5. Mathematical formulations have been developed in the framework of the modified bethe-tait method, and scoping analyses have been performed for the KALIMER core behavior during super-prompt critical excursions.

  13. Preliminary RAMI analysis of DFLL TBS for ITER

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Dagui [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); University of Science and Technology of China, Hefei, Anhui, 230031 (China); Yuan, Run [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); Wang, Jiaqun, E-mail: jiaqun.wang@fds.org.cn [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China); Wang, Fang; Wang, Jin [Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui, 230031 (China)

    2016-11-15

    Highlights: • We performed the functional analysis of the DFLL TBS. • We performed a failure mode analysis of the DFLL TBS. • We estimated the reliability and availability of the DFLL TBS. • The ITER RAMI approach was applied to the DFLL TBS for technical risk control in the design phase. - Abstract: ITER is the first fusion machine fully designed to prove the physics and technological basis for next fusion power plants. Among the main technical objectives of ITER is to test and validate design concepts of tritium breeding blankets relevant to the fusion power plants. To achieve this goal, China has proposed the dual functional lithium-lead test blanket module (DFLL TBM) concept design. The DFLL TBM and its associated ancillary system were called DFLL TBS. The DFLL TBS play a key role in next fusion reactor. In order to ensure reliable and available of DFLL TBS, the risk control project of DFLL TBS has been put on the schedule. As the stage of the ITER technical risk control policy, the RAMI (Reliability, Availability, Maintainability, Inspectability) approach was used to control the technical risk of ITER. In this paper, the RAMI approach was performed on the conceptual design of DFLL TBS. A functional breakdown was prepared on DFLL TBS, and the system was divided into 3 main functions and 72 basic functions. Based on the result of functional breakdown of DFLL TBS, the reliability block diagrams were prepared to estimate the reliability and availability of each function under the stipulated operating conditions. The inherent availability of the DFLL TBS expected after implementation of mitigation actions was calculated to be 98.57% over 2 years based on the ITER reliability database. A Failure Modes Effects and Criticality Analysis (FMECA) was performed with criticality charts highlighting the risk level of the different failure modes with regard to their probability of occurrence and their effects on the availability.

  14. Macroalgae as a Biomass Feedstock: A Preliminary Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Roesijadi, Guritno; Jones, Susanne B.; Snowden-Swan, Lesley J.; Zhu, Yunhua

    2010-09-26

    A thorough of macroalgae analysis as a biofuels feedstock is warranted due to the size of this biomass resource and the need to consider all potential sources of feedstock to meet current biomass production goals. Understanding how to harness this untapped biomass resource will require additional research and development. A detailed assessment of environmental resources, cultivation and harvesting technology, conversion to fuels, connectivity with existing energy supply chains, and the associated economic and life cycle analyses will facilitate evaluation of this potentially important biomass resource.

  15. Statistical Analysis of Time Series Data (STATS). Users Manual (Preliminary)

    Science.gov (United States)

    1987-05-01

    15, 30. 60, 90, 120, andL -!/14:X.... 183 days are presently used. auto Page 1 of 10 wrpy *VtsE0> J1 record (continued) Field Variab Vlue D 2 NPRDS ...each event. 6 JEND + Order number of last period in time series to ( NPRDS ) select for analysis. If blank, the last period is assumed. 7 JPPF Plotting...values. 2 NPRDS + Actual number of periods for the event following on ’INO records until the next ID, BF, or LI record. IN record - T:E SERIES DATA

  16. SINGLE-SHELL TANK INTEGRITY PROJECT ANALYSIS OF RECORD-PRELIMINARY MODELING PLAN FOR THERMAL AND OPERATING LOADS

    Energy Technology Data Exchange (ETDEWEB)

    RAST RS; RINKER MW; BAPANAALLI SK; DEIBLER JE; GUZMAN-LEONG CE; JOHNSON KI; KARRI NK; PILLI SP; SANBORN SE

    2010-10-22

    This document is a Phase I deliverable for the Single-Shell Tank Analysis of Record effort. This document is not the Analysis of Record. The intent of this document is to guide the Phase II detailed modeling effort. Preliminary finite element models for each of the tank types were developed and different case studies were performed on one or more of these tank types. Case studies evaluated include thermal loading, waste level variation, the sensitivity of boundary effects (soil radial extent), excavation slope or run to rise ratio, soil stratigraphic (property and layer thickness) variation at different farm locations, and concrete material property variation and their degradation under thermal loads. The preliminary analysis document reviews and preliminary modeling analysis results are reported herein. In addition, this report provides recommendations for the next phase of the SST AOR project, SST detailed modeling. Efforts and results discussed in this report do not include seismic modeling as seismic modeling is covered by a separate report. The combined results of both static and seismic models are required to complete this effort. The SST AOR project supports the US Department of Energy's (DOE) Office of River Protection (ORP) mission for obtaining a better understanding of the structural integrity of Hanford's SSTs. The 149 SSTs, with six different geometries, have experienced a range of operating histories which would require a large number of unique analyses to fully characterize their individual structural integrity. Preliminary modeling evaluations were conducted to determine the number of analyses required for adequate bounding of each of the SST tank types in the Detailed Modeling Phase of the SST AOR Project. The preliminary modeling was conducted in conjunction with the Evaluation Criteria report, Johnson et al. (2010). Reviews of existing documents were conducted at the initial stage of preliminary modeling. These reviews guided the topics

  17. Analysis of Frequency Characteristics and Sensitivity of Compliant Mechanisms

    Institute of Scientific and Technical Information of China (English)

    LIU Shanzeng; DAI Jiansheng; LI Aimin; SUN Zhaopeng; FENG Shizhe; CAO Guohua

    2016-01-01

    Based on a modified pseudo-rigid-body model, the frequency characteristics and sensitivity of the large-deformation compliant mechanism are studied. Firstly, the pseudo-rigid-body model under the static and kinetic conditions is modified to enable the modified pseudo-rigid-body model to be more suitable for the dynamic analysis of the compliant mechanism. Subsequently, based on the modified pseudo-rigid-body model, the dynamic equations of the ordinary compliant four-bar mechanism are established using the analytical mechanics. Finally, in combination with the finite element analysis software ANSYS, the frequency characteristics and sensitivity of the compliant mechanism are analyzed by taking the compliant parallel-guiding mechanism and the compliant bistable mechanism as examples. From the simulation results, the dynamic characteristics of compliant mechanism are relatively sensitive to the structure size, section parameter, and characteristic parameter of material on mechanisms. The results could provide great theoretical significance and application values for the structural optimization of compliant mechanisms, the improvement of their dynamic properties and the expansion of their application range.

  18. An analytic method for sensitivity analysis of complex systems

    Science.gov (United States)

    Zhu, Yueying; Wang, Qiuping Alexandre; Li, Wei; Cai, Xu

    2017-03-01

    Sensitivity analysis is concerned with understanding how the model output depends on uncertainties (variances) in inputs and identifying which inputs are important in contributing to the prediction imprecision. Uncertainty determination in output is the most crucial step in sensitivity analysis. In the present paper, an analytic expression, which can exactly evaluate the uncertainty in output as a function of the output's derivatives and inputs' central moments, is firstly deduced for general multivariate models with given relationship between output and inputs in terms of Taylor series expansion. A γ-order relative uncertainty for output, denoted by Rvγ, is introduced to quantify the contributions of input uncertainty of different orders. On this basis, it is shown that the widely used approximation considering the first order contribution from the variance of input variable can satisfactorily express the output uncertainty only when the input variance is very small or the input-output function is almost linear. Two applications of the analytic formula are performed to the power grid and economic systems where the sensitivities of both actual power output and Economic Order Quantity models are analyzed. The importance of each input variable in response to the model output is quantified by the analytic formula.

  19. Analysis of frequency characteristics and sensitivity of compliant mechanisms

    Science.gov (United States)

    Liu, Shanzeng; Dai, Jiansheng; Li, Aimin; Sun, Zhaopeng; Feng, Shizhe; Cao, Guohua

    2016-07-01

    Based on a modified pseudo-rigid-body model, the frequency characteristics and sensitivity of the large-deformation compliant mechanism are studied. Firstly, the pseudo-rigid-body model under the static and kinetic conditions is modified to enable the modified pseudo-rigid-body model to be more suitable for the dynamic analysis of the compliant mechanism. Subsequently, based on the modified pseudo-rigid-body model, the dynamic equations of the ordinary compliant four-bar mechanism are established using the analytical mechanics. Finally, in combination with the finite element analysis software ANSYS, the frequency characteristics and sensitivity of the compliant mechanism are analyzed by taking the compliant parallel-guiding mechanism and the compliant bistable mechanism as examples. From the simulation results, the dynamic characteristics of compliant mechanism are relatively sensitive to the structure size, section parameter, and characteristic parameter of material on mechanisms. The results could provide great theoretical significance and application values for the structural optimization of compliant mechanisms, the improvement of their dynamic properties and the expansion of their application range.

  20. Optimizing human activity patterns using global sensitivity analysis.

    Science.gov (United States)

    Fairchild, Geoffrey; Hickmann, Kyle S; Mniszewski, Susan M; Del Valle, Sara Y; Hyman, James M

    2014-12-01

    Implementing realistic activity patterns for a population is crucial for modeling, for example, disease spread, supply and demand, and disaster response. Using the dynamic activity simulation engine, DASim, we generate schedules for a population that capture regular (e.g., working, eating, and sleeping) and irregular activities (e.g., shopping or going to the doctor). We use the sample entropy (SampEn) statistic to quantify a schedule's regularity for a population. We show how to tune an activity's regularity by adjusting SampEn, thereby making it possible to realistically design activities when creating a schedule. The tuning process sets up a computationally intractable high-dimensional optimization problem. To reduce the computational demand, we use Bayesian Gaussian process regression to compute global sensitivity indices and identify the parameters that have the greatest effect on the variance of SampEn. We use the harmony search (HS) global optimization algorithm to locate global optima. Our results show that HS combined with global sensitivity analysis can efficiently tune the SampEn statistic with few search iterations. We demonstrate how global sensitivity analysis can guide statistical emulation and global optimization algorithms to efficiently tune activities and generate realistic activity patterns. Though our tuning methods are applied to dynamic activity schedule generation, they are general and represent a significant step in the direction of automated tuning and optimization of high-dimensional computer simulations.

  1. A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia.

    Directory of Open Access Journals (Sweden)

    Jianliang Ni

    Full Text Available Complement pathway activation was found to occur frequently in schizophrenia, and complement 3 (C3 plays a major role in this process. Previous studies have provided evidence for the possible role of C3 in the development of schizophrenia. In this study, we hypothesized that the gene encoding C3 (C3 may confer susceptibility to schizophrenia in Han Chinese. We analyzed 7 common single nucleotide polymorphisms (SNPs of C3 in 647 schizophrenia patients and 687 healthy controls. Peripheral C3 mRNA expression level was measured in 23 drug-naïve patients with schizophrenia and 24 controls. Two SNPs (rs1047286 and rs2250656 that deviated from Hardy-Weinberg equilibrium were excluded for further analysis. Among the remaining 5 SNPs, there was no significant difference in allele and genotype frequencies between the patient and control groups. Logistic regression analysis showed no significant SNP-gender interaction in either dominant model or recessive model. There was no significant difference in the level of peripheral C3 expression between the drug-naïve schizophrenia patients and healthy controls. In conclusion, the results of this study do not support C3 as a major genetic susceptibility factor in schizophrenia. Other factors in AP may have critical roles in schizophrenia and be worthy of further investigation.

  2. Sensitivity and Uncertainty Analysis of Regional Marine Ecosystem Services Value

    Institute of Scientific and Technical Information of China (English)

    SHI Honghua; ZHENG Wei; WANG Zongling; DING Dewen

    2009-01-01

    Marine ecosystem services are the benefits which people obtain from the marine ecosystem, including provisioning ser-vices, regulating services, cultural services and supporting services. The human species, while buffered against environmental changes by culture and technology, is fundamentally dependent on the flow of ecosystem services. Marine ecosystem services be-come increasingly valuable as the terrestrial resources become scarce. The value of marine ecosystem services is the monetary flow of ecosystem services on specific temporal and spatial scales, which often changes due to the variation of the goods prices, yields and the status of marine exploitation. Sensitivity analysis is to study the relationship between the value of marine ecosystem services and the main factors which affect it. Uncertainty analysis based on varying prices, yields and status of marine exploitation was carried out. Through uncertainty analysis, a more credible value range instead of a fixed value of marine ecosystem services was obtained in this study. Moreover, sensitivity analysis of the marine ecosystem services value revealed the relative importance of different factors.

  3. Multi-criteria decision making: an example of sensitivity analysis

    Directory of Open Access Journals (Sweden)

    Dragan S. Pamučar

    2017-05-01

    Full Text Available This study provides a model for result consistency evaluation of multicriterial decision making (MDM methods and selection of the optimal one. The model is based on the analysis of results of MDM methods, that is, the analysis of changes in rankings of MDM methods that occur as a result of alterations in input parameters. In the recommended model, we examine sensitivity analysis of MDM methods to changes in criteria weight and result consistency of methods to changes in measurement scale and the way in which we formulate criteria. In the final phase of the model, we select the most suitable method to solve the observed problem and the optimal alternative. The model is tested on an example, when the optimal MDM method selection was required in order to determine the location of the logistical center. During the selection process, TOPSIS, COPRAS, VIKOR and ELECTRE methods were considered. VIKOR method demonstrated the biggest stability of rankings and was selected as the most fit method for ranking the locations of the logistical center. Results of the demonstrated analysis indicate sensitivity of standard MDM methods to criteria considered in this work. Therefore, it is necessary, to take into account stability of the considered method during the selection process of the optimal method.

  4. Brain hemisphere dominance and vocational preference: a preliminary analysis.

    Science.gov (United States)

    Szirony, Gary Michael; Pearson, L Carolyn; Burgin, John S; Murray, Gerald C; Elrod, Lisa Marie

    2007-01-01

    Recent developments in split-brain theory add support to the concept of specialization within brain hemispheres. Holland's vocational personality theory may overlap with Human Information Processing (HIP) characteristics. Holland's six RIASEC codes were developed to identify vocational personality characteristics, and HIP scales were designed to measure hemispheric laterality. Relationships between the two scales were evaluated through canonical correlation with some significant results, however not all Holland scale scores correlated with left, right, or integrated hemispheric preference. Additional findings related to participants self-perception of music and math ability were also correlated. Findings on this added analysis revealed a high correlation between perception of musical ability and right brain function but not between mathematical concept and left brain alone. Implications regarding vocational choice and work are discussed.

  5. City of Hoboken Energy Surety Analysis: Preliminary Design Summary

    Energy Technology Data Exchange (ETDEWEB)

    Stamp, Jason Edwin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Military and Energy Systems Analysis Dept.; Baca, Michael J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Military and Energy Systems Analysis Dept.; Munoz-Ramos, Karina [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Military and Energy Systems Analysis Dept.; Schenkman, Benjamin L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Military and Energy Systems Analysis Dept.; Eddy, John P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Systems Readiness and Sustainment Technology Dept.; Smith, Mark A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Systems Readiness and Sustainment Technology Dept.; Guttromson, Ross [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Electric Power Systems Research Dept.; Henry, Jordan M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Critical Infrastructure Systems Dept.; Jensen, Richard Pearson [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Geomechanics Dept.

    2014-09-01

    In 2012, Hurricane Sandy devastated much of the U.S. northeast coastal areas. Among those hardest hit was the small community of Hoboken, New Jersey, located on the banks of the Hudson River across from Manhattan. This report describes a city-wide electrical infrastructure design that uses microgrids and other infrastructure to ensure the city retains functionality should such an event occur in the future. The designs ensure that up to 55 critical buildings will retain power during blackout or flooded conditions and include analysis for microgrid architectures, performance parameters, system control, renewable energy integration, and financial opportunities (while grid connected). The results presented here are not binding and are subject to change based on input from the Hoboken stakeholders, the integrator selected to manage and implement the microgrid, or other subject matter experts during the detailed (final) phase of the design effort.

  6. Analysis of organochlorine pesticides in human milk: preliminary results.

    Science.gov (United States)

    Campoy, C; Jiménez, M; Olea-Serrano, M F; Moreno-Frías, M; Cañabate, F; Olea, N; Bayés, R; Molina-Font, J A

    2001-11-01

    In the face of evidence of human milk contamination by organochlorine pesticides, an analysis was performed on samples of milk obtained from healthy lactating women in the provinces of Granada and Almeria in Southern Spain. The samples were obtained by the Neonate Section of the Department of Pediatrics of Granada University Hospital (Neonatology Division) and by the Neonatal Service of Poniente Hospital in El Ejido, Almería. A liquid-liquid extraction procedure was performed. The cleaning of the sample before gas chromatography-mass spectrometry (GC-MS) used silica Sep-Pak. Among other pesticides, aldrin, dieldrin, DDT and its metabolites, lindane, methoxychlor and endosulfan were identified. The presence of these products was confirmed by mass spectrometry. The identification and quantification of these organochlorine molecules is important because they have estrogenic effects.

  7. Sensitivity Analysis Applied in Design of Low Energy Office Building

    DEFF Research Database (Denmark)

    Heiselberg, Per; Brohus, Henrik

    2008-01-01

    Building performance can be expressed by different indicators as primary energy use, environmental load and/or the indoor environmental quality and a building performance simulation can provide the decision maker with a quantitative measure of the extent to which an integrated design solution...... satisfies the design requirements and objectives. In the design of sustainable Buildings it is beneficial to identify the most important design parameters in order to develop more efficiently alternative design solutions or reach optimized design solutions. A sensitivity analysis makes it possible...... to identify the most important parameters in relation to building performance and to focus design and optimization of sustainable buildings on these fewer, but most important parameters. The sensitivity analyses will typically be performed at a reasonably early stage of the building design process, where...

  8. Sensitivity analysis of GSI based mechanical characterization of rock mass

    CERN Document Server

    Ván, P

    2012-01-01

    Recently, the rock mechanical and rock engineering designs and calculations are frequently based on Geological Strength Index (GSI) method, because it is the only system that provides a complete set of mechanical properties for design purpose. Both the failure criteria and the deformation moduli of the rock mass can be calculated with GSI based equations, which consists of the disturbance factor, as well. The aim of this paper is the sensitivity analysis of GSI and disturbance factor dependent equations that characterize the mechanical properties of rock masses. The survey of the GSI system is not our purpose. The results show that the rock mass strength calculated by the Hoek-Brown failure criteria and both the Hoek-Diederichs and modified Hoek-Diederichs deformation moduli are highly sensitive to changes of both the GSI and the D factor, hence their exact determination is important for the rock engineering design.

  9. Sensitivity Analysis of Hardwired Parameters in GALE Codes

    Energy Technology Data Exchange (ETDEWEB)

    Geelhood, Kenneth J.; Mitchell, Mark R.; Droppo, James G.

    2008-12-01

    The U.S. Nuclear Regulatory Commission asked Pacific Northwest National Laboratory to provide a data-gathering plan for updating the hardwired data tables and parameters of the Gaseous and Liquid Effluents (GALE) codes to reflect current nuclear reactor performance. This would enable the GALE codes to make more accurate predictions about the normal radioactive release source term applicable to currently operating reactors and to the cohort of reactors planned for construction in the next few years. A sensitivity analysis was conducted to define the importance of hardwired parameters in terms of each parameter’s effect on the emission rate of the nuclides that are most important in computing potential exposures. The results of this study were used to compile a list of parameters that should be updated based on the sensitivity of these parameters to outputs of interest.

  10. Stability and Sensitivity Analysis of Fuzzy Control Systems. Mechatronics Applications

    Directory of Open Access Journals (Sweden)

    Radu-Emil Precup

    2006-01-01

    Full Text Available The development of fuzzy control systems is usually performed by heuristicmeans, incorporating human skills, the drawback being in the lack of general-purposedevelopment methods. A major problem, which follows from this development, is theanalysis of the structural properties of the control system, such as stability, controllabilityand robustness. Here comes the first goal of the paper, to present a stability analysismethod dedicated to fuzzy control systems with mechatronics applications based on the useof Popov’s hyperstability theory. The second goal of this paper is to perform the sensitivityanalysis of fuzzy control systems with respect to the parametric variations of the controlledplant for a class of servo-systems used in mechatronics applications based on theconstruction of sensitivity models. The stability and sensitivity analysis methods provideuseful information to the development of fuzzy control systems. The case studies concerningfuzzy controlled servo-systems, accompanied by digital simulation results and real-timeexperimental results, validate the presented methods.

  11. Parametric Variations Sensitivity Analysis on IM Discrete Speed Estimation

    Directory of Open Access Journals (Sweden)

    Mohamed BEN MESSAOUD

    2007-09-01

    Full Text Available Motivation: This paper will discuss sensitivity issues in rotor speed estimation for induction machine (IM drives using only voltage and current measurements. A supervised estimation algorithm is proposed with the aim to achieve good performances in the large variations of the speed. After a brief presentation on discrete feedback structure of the estimator formulated from d-q axis equations, we will expose its performances for machine parameters variations.Method: Hyperstability concept was applied to the synthesis adaptation low. A heuristic term is added to the algorithm to maintain good speed estimation factor in high speeds.Results: In simulation, the estimation error is maintained relatively low in wide range of speeds, and the robustness of the estimation algorithm is shown for machine parametric variations.Conclusions: Sensitivity analysis to motor parameter changes of proposed sensorless IM is then performed.

  12. Preliminary analysis of cerebrospinal fluid proteome in patients with neurocysticercosis

    Institute of Scientific and Technical Information of China (English)

    TIAN Xiao-jun; LI Jing-yi; HUANG Yong; XUE Yan-ping

    2009-01-01

    Background Neurocysticercosis is the infection of the nervous system by the larvae of Taenia solium (T. solium). Despite continuous effort, the experimental diagnosis of neurocysticercosis remains unresolved. Since the cerebrospinal fluid (CSF) contacts with the brain, dynamic information about pathological processes of the brain is likely to be reflected in CSF. Therefore, CSF may serve as a rich source of putative biomarkers related to neurocysticercosis. Comparative proteomic analysis of CSF of neurocysticercosis patients and control subjects may find differentially expressed proteins. Methods Two-dimensional difference in gel electrophoresis (2D-DIGE) was used to investigate differentially expressed proteins in CSF of patients with neurocysticercosis by comparing the protein profile of CSF from neurocysticercosis patients with that from control subjects. The differentially expressed spots/proteins were recognized with matrix-assisted laser desorption/ionization-time of flight-time of flight (MALDI-TOF-TOF) mass spectrometry. Results Forty-four enzyme digested peptides were obtained from 4 neurocysticercotic patients. Twenty-three were identified through search of the NCBI protein database with Mascot software, showing 19 up-expressed and 4 down-expressed. Of these proteins, 26S proteosome related to ATP- and ubiquitin-dependent degradation of proteins and lipocalin type prostaglandin D synthase involved in PGD2-synthesis and extracellular transporter activities were up-expressed, while transferrin related to iron metabolism within the brain was down-expressed. Conclusions This study established the proteomic profile of pooled CSF from 4 patients with neurocysticercosis, suggesting the potential value of proteomic analysis for the study of candidate biomarkers involved in the diagnosis or pathogenesis of neurocysticercosis.

  13. Preliminary analysis of the use of smartwatches for longitudinal health monitoring.

    Science.gov (United States)

    Jovanov, Emil

    2015-08-01

    New generations of smartwatches feature continuous measurement of physiological parameters, such as heart rate, galvanic skin resistance (GSR), and temperature. In this paper we present the results of preliminary analysis of the use of Basis Peak smartwatch for longitudinal health monitoring during a 4 month period. Physiological measurements during sleep are validated using Zephyr Bioharness 3 monitor and SOMNOscreen+ polysomnographic monitoring system from SOMNOmedics. Average duration of sequences with no missed data was 49.9 minutes, with maximum length of 17 hours, and they represent 88.88% of recording time. Average duration of the charging event was 221.9 min, and average time between charges was 54 hours, with maximum duration of the charging event of 16.3 hours. Preliminary results indicate that the physiological monitoring performance of existing smartwatches provides sufficient performance for longitudinal monitoring of health status and analysis of health and wellness trends.

  14. Relative risk analysis in regulating the use of radiation-emitting medical devices. A preliminary application

    Energy Technology Data Exchange (ETDEWEB)

    Jones, E.D.; Banks, W.W.; Altenbach, T.J.; Fischer, L.E. [Lawrence Livermore National Lab., CA (United States)

    1995-09-01

    This report describes a preliminary application of an analysis approach for assessing relative risks in the use of radiation- emitting medical devices. Results are presented on human-initiated actions and failure modes that are most likely to occur in the use of the Gamma Knife, a gamma irradiation therapy device. This effort represents an initial step in a US Nuclear Regulatory Commission (NRC) plan to evaluate the potential role of risk analysis in regulating the use of nuclear medical devices. For this preliminary application of risk assessment, the focus was to develop a basic process using existing techniques for identifying the most likely risk contributors and their relative importance. The approach taken developed relative risk rankings and profiles that incorporated the type and quality of data available and could present results in an easily understood form. This work was performed by the Lawrence Livermore National Laboratory for the NRC.

  15. A Preliminary Tsunami Vulnerability Analysis for Yenikapi Region in Istanbul

    Science.gov (United States)

    Ceren Cankaya, Zeynep; Suzen, Lutfi; Cevdet Yalciner, Ahmet; Kolat, Cagil; Aytore, Betul; Zaytsev, Andrey

    2015-04-01

    One of the main requirements during post disaster recovery operations is to maintain proper transportation and fluent communication at the disaster areas. Ports and harbors are the main transportation hubs which must work with proper performance at all times especially after the disasters. Resilience of coastal utilities after earthquakes and tsunamis have major importance for efficient and proper rescue and recovery operations soon after the disasters. Istanbul is a mega city with its various coastal utilities located at the north coast of the Sea of Marmara. At Yenikapi region of Istanbul, there are critical coastal utilities and vulnerable coastal structures and critical activities occur daily. Fishery ports, commercial ports, small craft harbors, passenger terminals of intercity maritime transportation, water front commercial and/or recreational structures are some of the examples of coastal utilization which are vulnerable against marine disasters. Therefore their vulnerability under tsunami or any other marine hazard to Yenikapi region of Istanbul is an important issue. In this study, a methodology of vulnerability analysis under tsunami attack is proposed with the applications to Yenikapi region. In the study, high resolution (1m) GIS database of Istanbul Metropolitan Municipality (IMM) is used and analyzed by using GIS implementation. The bathymetry and topography database and the vector dataset containing all buildings/structures/infrastructures in the study area are obtained for tsunami numerical modeling for the study area. GIS based tsunami vulnerability assessment is conducted by applying the Multi-criteria Decision Making Analysis (MCDA). The tsunami parameters from deterministically defined worst case scenarios are computed from the simulations using tsunami numerical model NAMI DANCE. The vulnerability parameters in the region due to two different classifications i) vulnerability of buildings/structures and ii) vulnerability of (human) evacuation

  16. Biosphere dose conversion Factor Importance and Sensitivity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. Wasiolek

    2004-10-15

    This report presents importance and sensitivity analysis for the environmental radiation model for Yucca Mountain, Nevada (ERMYN). ERMYN is a biosphere model supporting the total system performance assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis concerns the output of the model, biosphere dose conversion factors (BDCFs) for the groundwater, and the volcanic ash exposure scenarios. It identifies important processes and parameters that influence the BDCF values and distributions, enhances understanding of the relative importance of the physical and environmental processes on the outcome of the biosphere model, includes a detailed pathway analysis for key radionuclides, and evaluates the appropriateness of selected parameter values that are not site-specific or have large uncertainty.

  17. Sammon mapping for preliminary analysis in Hyperspectral Imagery

    Directory of Open Access Journals (Sweden)

    Nicolae APOSTOLESCU

    2016-03-01

    Full Text Available The main goal of this paper is to present the implementation of the Sammon algorithm developed for finding N points in a lower m-dimensional subspace, where the original points are from a high n-dimensional space. This mapping is done so interpoints Euclidian distances in m-space correspond to the distances measured in the n-dimensional space. This method known as non-linear projection method or multidimensional scaling (MDS aims to preserve the global properties of points. The method is based on the idea of transforming the original, n-dimensional input space into a reduced, m-dimensional one, where mAnalysis (PCA may be applied as a pre-processing procedure for starting, in order to obtain the N points in the lower subspace. The algorithm was tested on hyperspectral data with spectra of various lengths. Depending of the size of the input data (number of points, the number of learning iterations and computational facilities available, Sammon mapping might be computationally expensive.

  18. A simplified procedure of linear regression in a preliminary analysis

    Directory of Open Access Journals (Sweden)

    Silvia Facchinetti

    2013-05-01

    Full Text Available The analysis of a statistical large data-set can be led by the study of a particularly interesting variable Y – regressed – and an explicative variable X, chosen among the remained variables, conjointly observed. The study gives a simplified procedure to obtain the functional link of the variables y=y(x by a partition of the data-set into m subsets, in which the observations are synthesized by location indices (mean or median of X and Y. Polynomial models for y(x of order r are considered to verify the characteristics of the given procedure, in particular we assume r= 1 and 2. The distributions of the parameter estimators are obtained by simulation, when the fitting is done for m= r + 1. Comparisons of the results, in terms of distribution and efficiency, are made with the results obtained by the ordinary least square methods. The study also gives some considerations on the consistency of the estimated parameters obtained by the given procedure.

  19. Preliminary Analysis of Slope Stability in Kuok and Surrounding Areas

    Directory of Open Access Journals (Sweden)

    Dewandra Bagus Eka Putra

    2016-12-01

    Full Text Available The level of slope influenced by the condition of the rocks beneath the surface. On high level of slopes, amount of surface runoff and water transport energy is also enlarged. This caused by greater gravity, in line with the surface tilt from the horizontal plane. In other words, topsoil eroded more and more. When the slope becomes twice as steep, then the amount of erosion per unit area be 2.0 - 2.5 times more. Kuok and surrounding area is the road access between the West Sumatra and Riau which plays an important role economies of both provinces. The purpose of this study is to map the locations that have fairly steep slopes and potential mode of landslides. Based on SRTM data obtained,  the roads in Kuok area has a minimum elevation of + 33 m and a maximum  + 217.329 m. Rugged road conditions with slope ranging from 24.08 ° to 44.68 ° causing this area having frequent landslides. The result of slope stability analysis in a slope near the Water Power Plant Koto Panjang, indicated that mode of active failure is toppling failure or rock fall and the potential zone of failure is in the center part of the slope.

  20. Social network analysis in identifying influential webloggers: A preliminary study

    Science.gov (United States)

    Hasmuni, Noraini; Sulaiman, Nor Intan Saniah; Zaibidi, Nerda Zura

    2014-12-01

    In recent years, second generation of internet-based services such as weblog has become an effective communication tool to publish information on the Web. Weblogs have unique characteristics that deserve users' attention. Some of webloggers have seen weblogs as appropriate medium to initiate and expand business. These webloggers or also known as direct profit-oriented webloggers (DPOWs) communicate and share knowledge with each other through social interaction. However, survivability is the main issue among DPOW. Frequent communication with influential webloggers is one of the way to keep survive as DPOW. This paper aims to understand the network structure and identify influential webloggers within the network. Proper understanding of the network structure can assist us in knowing how the information is exchanged among members and enhance survivability among DPOW. 30 DPOW were involved in this study. Degree centrality and betweenness centrality measurement in Social Network Analysis (SNA) were used to examine the strength relation and identify influential webloggers within the network. Thus, webloggers with the highest value of these measurements are considered as the most influential webloggers in the network.

  1. SLUDGE TREATMENT PROJECT ENGINEERED CONTAINER RETRIEVAL AND TRANSFER SYSTEM PRELIMINARY DESIGN HAZARD ANALYSIS SUPPLEMENT 1

    Energy Technology Data Exchange (ETDEWEB)

    FRANZ GR; MEICHLE RH

    2011-07-18

    This 'What/If' Hazards Analysis addresses hazards affecting the Sludge Treatment Project Engineered Container Retrieval and Transfer System (ECRTS) NPH and external events at the preliminary design stage. In addition, the hazards of the operation sequence steps for the mechanical handling operations in preparation of Sludge Transport and Storage Container (STSC), disconnect STSC and prepare STSC and Sludge Transport System (STS) for shipping are addressed.

  2. Preliminary Failure Modes and Effects Analysis of the US Massive Gas Injection Disruption Mitigation System Design

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader

    2013-10-01

    This report presents the results of a preliminary failure modes and effects analysis (FMEA) of a candidate design for the ITER Disruption Mitigation System. This candidate is the Massive Gas Injection System that provides machine protection in a plasma disruption event. The FMEA was quantified with “generic” component failure rate data as well as some data calculated from operating facilities, and the failure events were ranked for their criticality to system operation.

  3. Preliminary Failure Modes and Effects Analysis of the US DCLL Test Blanket Module

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader

    2007-08-01

    This report presents the results of a preliminary failure modes and effects analysis (FMEA) of a small tritium-breeding test blanket module design for the International Thermonuclear Experimental Reactor. The FMEA was quantified with “generic” component failure rate data, and the failure events are binned into postulated initiating event families and frequency categories for safety assessment. An appendix to this report contains repair time data to support an occupational radiation exposure assessment for test blanket module maintenance.

  4. Preliminary Failure Modes and Effects Analysis of the US DCLL Test Blanket Module

    Energy Technology Data Exchange (ETDEWEB)

    Lee C. Cadwallader

    2010-06-01

    This report presents the results of a preliminary failure modes and effects analysis (FMEA) of a small tritium-breeding test blanket module design for the International Thermonuclear Experimental Reactor. The FMEA was quantified with “generic” component failure rate data, and the failure events are binned into postulated initiating event families and frequency categories for safety assessment. An appendix to this report contains repair time data to support an occupational radiation exposure assessment for test blanket module maintenance.

  5. Sensitivity Analysis of OECD Benchmark Tests in BISON

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gamble, Kyle [Idaho National Lab. (INL), Idaho Falls, ID (United States); Schmidt, Rodney C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Williamson, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    This report summarizes a NEAMS (Nuclear Energy Advanced Modeling and Simulation) project focused on sensitivity analysis of a fuels performance benchmark problem. The benchmark problem was defined by the Uncertainty Analysis in Modeling working group of the Nuclear Science Committee, part of the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (OECD ). The benchmark problem involv ed steady - state behavior of a fuel pin in a Pressurized Water Reactor (PWR). The problem was created in the BISON Fuels Performance code. Dakota was used to generate and analyze 300 samples of 17 input parameters defining core boundary conditions, manuf acturing tolerances , and fuel properties. There were 24 responses of interest, including fuel centerline temperatures at a variety of locations and burnup levels, fission gas released, axial elongation of the fuel pin, etc. Pearson and Spearman correlatio n coefficients and Sobol' variance - based indices were used to perform the sensitivity analysis. This report summarizes the process and presents results from this study.

  6. PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ACUTE ORAL TOXICITY STUDY OF CLITORIA TERNATEA LINN. ROOTS IN ALBINO MICE

    Directory of Open Access Journals (Sweden)

    Deka Manalisha

    2011-12-01

    Full Text Available Clitoria ternatea has been using since the ancient times for its medicinal values. Almost all the parts of the plant have medicinal property. The root of the plant is reported to have anti diarrheal, Anti histamic, cholinergic activity etc. Traditionally the root has been using for the treatment of many diseases like leucorrhoea, diarrhea, urinary problems, diuretic, impotency, stomach trouble etc. The present study was designed to investigate the preliminary phytochemical analysis and acute oral toxicity of the root of the plant. The shed dried materials were grinded and used in the study. The preliminary phytochemical analysis was done by following standard protocols. For acute oral toxicity study, methanolic extract of the root was used. The extract was prepared by standard protocol. The preliminary phytochemical analysis showed the presence of proteins, carbohydrates, glycosides, resins, saponin, flavonoid, alkaloids, steroids and phenol. The acute oral toxicity study showed no mortality up to a dose of 3000 mg per kg body weight. The presence of plant chemicals revealed the medicinal values and the non toxic property of the plant indicated the value of the plant as medicine. Thus we can conclude that, the root of the plant can be used as a safe drug against many diseases.

  7. PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ACUTE ORAL TOXICITY STUDY OF MUCUNA PRURIENS LINN. IN ALBINO MICE

    Directory of Open Access Journals (Sweden)

    Deka Manalisha

    2012-02-01

    Full Text Available Mucuna Pruriens Linn. is an annual, climbing shrub which has an important place among aphrodisiac herbs in India since the ancient times. The plant has been using traditionally for many medicinal purposes such as Infertility, Parkinson’s disease, Loss of libido, Antioxidant, Anti venom, Anti microbial etc. The present study was carried out to investigate the preliminary phytochemical analysis and acute oral toxicity of the seeds of M.pruriens on albino mice. Matured seeds of M.pruriens were dried in shed and grinded in a mechanical grinder. The preliminary phytochemical analysis was done by following standard protocols. For acute oral toxicity study, methanolic extract of the seeds were used. The extract was prepared in a Soxlet apparatus. The preliminary phytochemical analysis showed the presence of protein, carbohydrates, glycosides, alkaloids, steroids, flavonoids, phenols and tannins. The acute oral toxicity study showed no mortality up to a dose of 4000 mg per kg body weight. The presence of plant chemicals revealed the medicinal values and the non toxic property of the plant indicated the value of the plant as medicine. Thus, we can conclude that, the seed of the plant can be used as a safe drug against many diseases.

  8. Path-sensitive analysis for reducing rollback overheads

    Science.gov (United States)

    O'Brien, John K.P.; Wang, Kai-Ting Amy; Yamashita, Mark; Zhuang, Xiaotong

    2014-07-22

    A mechanism is provided for path-sensitive analysis for reducing rollback overheads. The mechanism receives, in a compiler, program code to be compiled to form compiled code. The mechanism divides the code into basic blocks. The mechanism then determines a restore register set for each of the one or more basic blocks to form one or more restore register sets. The mechanism then stores the one or more register sets such that responsive to a rollback during execution of the compiled code. A rollback routine identifies a restore register set from the one or more restore register sets and restores registers identified in the identified restore register set.

  9. SENSITIVITY ANALYSIS FOR SALTSTONE DISPOSAL UNIT COLUMN DEGRADATION ANALYSES

    Energy Technology Data Exchange (ETDEWEB)

    Flach, G.

    2014-10-28

    PORFLOW related analyses supporting a Sensitivity Analysis for Saltstone Disposal Unit (SDU) column degradation were performed. Previous analyses, Flach and Taylor 2014, used a model in which the SDU columns degraded in a piecewise manner from the top and bottom simultaneously. The current analyses employs a model in which all pieces of the column degrade at the same time. Information was extracted from the analyses which may be useful in determining the distribution of Tc-99 in the various SDUs throughout time and in determining flow balances for the SDUs.

  10. N170 sensitivity to facial expression: A meta-analysis.

    Science.gov (United States)

    Hinojosa, J A; Mercado, F; Carretié, L

    2015-08-01

    The N170 component is the most important electrophysiological index of face processing. Early studies concluded that it was insensitive to facial expression, thus supporting dual theories postulating separate mechanisms for identity and expression encoding. However, recent evidence contradicts this assumption. We conducted a meta-analysis to resolve inconsistencies and to derive theoretical implications. A systematic revision of 128 studies analyzing N170 in response to neutral and emotional expressions yielded 57 meta-analyzable experiments (involving 1645 healthy adults). First, the N170 was found to be sensitive to facial expressions, supporting proposals arguing for integrated rather than segregated mechanisms in the processing of identity and expression. Second, this sensitivity is heterogeneous, with anger, fear and happy faces eliciting the largest N170 amplitudes. Third, we explored some modulatory factors, including the focus of attention - N170 amplitude was found to be also sensitive to unattended expressions - or the reference electrode -common reference reinforcing the effects- . In sum, N170 is a valuable tool to study the neural processing of facial expressions in order to develop current theories. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Sensitivity analysis for high percentiles of ochratoxim-a exposure distribution

    Energy Technology Data Exchange (ETDEWEB)

    Albert, I.; Gauchi, J. P.

    2001-07-01

    High percentile estimations of the exposure to the mycotoxin Ochratoxin-A (OTA) in food, for the French population, were calculated in a previous study by a Monte Carlo type simulation method from real consumption and contamination data. In this paper, from the same data (but only for the children class), we focus on sensitivity analysis (SA) of the high 95 th and 99 th percentiles (the simulation outputs), relatively to the variation of the parameters of the fitted probability density functions (the simulation inputs), necessary for having a relevant and stable estimation of these percentiles. After some preliminary trials, we postulated a quadratic polynomial model and we used an experimental design approach depending on a resolution-V fractional factorial design of 6561 experiments to lead to an optimal estimation of the polynomial model parameters. The factors ranges were established by bootstrap sampling taking into account the consumption dependencies by the Iman and Conover method and, eventually, taking into account the parameter correlation of the fitted probability densities. Finally, we have validated and useful parsimonious polynomial models for each desired percentile showing a major influence of the distribution parameters of the two foods Cereals and Pork, and eventually three with Fruit Juices in the sensitivity of the percentiles. (Author) 7 refs.

  12. Preliminary CFD Analysis for HVAC System Design of a Containment Building

    Energy Technology Data Exchange (ETDEWEB)

    Son, Sung Man; Choi, Choengryul [ELSOLTEC, Yongin (Korea, Republic of); Choo, Jae Ho; Hong, Moonpyo; Kim, Hyungseok [KEPCO Engineering and Construction, Gimcheon (Korea, Republic of)

    2016-10-15

    HVAC (Heating, Ventilation, Air Conditioning) system has been mainly designed based on overall heat balance and averaging concepts, which is simple and useful for designing overall system. However, such a method has the disadvantage that cannot predict the local flow and temperature distributions in a containment building. In this study, a CFD (Computational Fluid Dynamics) preliminary analysis is carried out to obtain detailed flow and temperature distributions in a containment building and to ensure that such information can be obtained via CFD analysis. This approach can be useful for hydrogen analysis in an accident related to hydrogen released into a containment building. In this study, CFD preliminary analysis has been performed to obtain the detailed information of the reactor containment building by using the CFD analysis techniques and to ensure that such information can be obtained via CFD analysis. We confirmed that CFD analysis can offer enough detailed information about flow patterns and temperature field and that CFD technique is a useful tool for HVAC design of nuclear power plants.

  13. Parametric sensitivity analysis for temperature control in outdoor photobioreactors.

    Science.gov (United States)

    Pereira, Darlan A; Rodrigues, Vinicius O; Gómez, Sonia V; Sales, Emerson A; Jorquera, Orlando

    2013-09-01

    In this study a critical analysis of input parameters on a model to describe the broth temperature in flat plate photobioreactors throughout the day is carried out in order to assess the effect of these parameters on the model. Using the design of experiment approach, variation of selected parameters was introduced and the influence of each parameter on the broth temperature was evaluated by a parametric sensitivity analysis. The results show that the major influence on the broth temperature is that from the reactor wall and the shading factor, both related to the direct and reflected solar irradiation. Other parameter which play an important role on the temperature is the distance between plates. This study provides information to improve the design and establish the most appropriate operating conditions for the cultivation of microalgae in outdoor systems.

  14. Sensitivity analysis of stochastically forced quasiperiodic self-oscillations

    Directory of Open Access Journals (Sweden)

    Irina Bashkirtseva

    2016-08-01

    Full Text Available We study a problem of stochastically forced quasi-periodic self-oscillations of nonlinear dynamic systems, which are modelled by an invariant torus in the phase space. For weak noise, an asymptotic of the stationary distribution of random trajectories is studied using the quasipotential. For the constructive analysis of a probabilistic distribution near a torus, we use a quadratic approximation of the quasipotential. A parametric description of this approximation is based on the stochastic sensitivity functions (SSF technique. Using this technique, we create a new mathematical method for the probabilistic analysis of stochastic flows near the torus. The construction of SSF is reduced to a boundary value problem for a linear differential matrix equation. For the case of the two-torus in the three-dimensional space, a constructive solution of this problem is given. Our theoretical results are illustrated with an example.

  15. Improved environmental multimedia modeling and its sensitivity analysis.

    Science.gov (United States)

    Yuan, Jing; Elektorowicz, Maria; Chen, Zhi

    2011-01-01

    Modeling of multimedia environmental issues is extremely complex due to the intricacy of the systems with the consideration of many factors. In this study, an improved environmental multimedia modeling is developed and a number of testing problems related to it are examined and compared with each other with standard numerical and analytical methodologies. The results indicate the flux output of new model is lesser in the unsaturated zone and groundwater zone compared with the traditional environmental multimedia model. Furthermore, about 90% of the total benzene flux was distributed to the air zone from the landfill sources and only 10% of the total flux emitted into the unsaturated, groundwater zones in non-uniform conditions. This paper also includes functions of model sensitivity analysis to optimize model parameters such as Peclet number (Pe). The analyses results show that the Pe can be considered as deterministic input variables for transport output. The oscillatory behavior is eliminated with the Pe decreased. In addition, the numerical methods are more accurate than analytical methods with the Pe increased. In conclusion, the improved environmental multimedia model system and its sensitivity analysis can be used to address the complex fate and transport of the pollutants in multimedia environments and then help to manage the environmental impacts.

  16. A Workflow for Global Sensitivity Analysis of PBPK Models

    Directory of Open Access Journals (Sweden)

    Kevin eMcNally

    2011-06-01

    Full Text Available Physiologically based pharmacokinetic models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can be integrated and utilised to translate information generated, using alternative to animal measures of toxicity and human biological monitoring data, into plausible corresponding exposures. However, these models invariably include the description of well known non-linear biological processes such as, enzyme saturation and interactions between parameters such as, organ mass and body mass. Therefore, an appropriate sensitivity analysis technique is required which can quantify the influences associated with individual parameters, interactions between parameters and any non-linear processes. In this report we have defined a workflow for sensitivity analysis of PBPK models that is computationally feasible, accounts for interactions between parameters, and can be displayed in the form of a bar chart and cumulative sum line (Lowry plot, which we believe is intuitive and appropriate for toxicologists, risk assessors and regulators.

  17. Orbit uncertainty propagation and sensitivity analysis with separated representations

    Science.gov (United States)

    Balducci, Marc; Jones, Brandon; Doostan, Alireza

    2017-09-01

    Most approximations for stochastic differential equations with high-dimensional, non-Gaussian inputs suffer from a rapid (e.g., exponential) increase of computational cost, an issue known as the curse of dimensionality. In astrodynamics, this results in reduced accuracy when propagating an orbit-state probability density function. This paper considers the application of separated representations for orbit uncertainty propagation, where future states are expanded into a sum of products of univariate functions of initial states and other uncertain parameters. An accurate generation of separated representation requires a number of state samples that is linear in the dimension of input uncertainties. The computation cost of a separated representation scales linearly with respect to the sample count, thereby improving tractability when compared to methods that suffer from the curse of dimensionality. In addition to detailed discussions on their construction and use in sensitivity analysis, this paper presents results for three test cases of an Earth orbiting satellite. The first two cases demonstrate that approximation via separated representations produces a tractable solution for propagating the Cartesian orbit-state uncertainty with up to 20 uncertain inputs. The third case, which instead uses Equinoctial elements, reexamines a scenario presented in the literature and employs the proposed method for sensitivity analysis to more thoroughly characterize the relative effects of uncertain inputs on the propagated state.

  18. Sensitivity Analysis of a Riparian Vegetation Growth Model

    Directory of Open Access Journals (Sweden)

    Michael Nones

    2016-11-01

    Full Text Available The paper presents a sensitivity analysis of two main parameters used in a mathematic model able to evaluate the effects of changing hydrology on the growth of riparian vegetation along rivers and its effects on the cross-section width. Due to a lack of data in existing literature, in a past study the schematization proposed here was applied only to two large rivers, assuming steady conditions for the vegetational carrying capacity and coupling the vegetal model with a 1D description of the river morphology. In this paper, the limitation set by steady conditions is overcome, imposing the vegetational evolution dependent upon the initial plant population and the growth rate, which represents the potential growth of the overall vegetation along the watercourse. The sensitivity analysis shows that, regardless of the initial population density, the growth rate can be considered the main parameter defining the development of riparian vegetation, but it results site-specific effects, with significant differences for large and small rivers. Despite the numerous simplifications adopted and the small database analyzed, the comparison between measured and computed river widths shows a quite good capability of the model in representing the typical interactions between riparian vegetation and water flow occurring along watercourses. After a thorough calibration, the relatively simple structure of the code permits further developments and applications to a wide range of alluvial rivers.

  19. GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of Jasminum cuspidatum leaves

    National Research Council Canada - National Science Library

    Singumsetty Vinay; Shaik Karimulla; Devarajan Saravanan

    2014-01-01

    The purpose of the present study was investigating the GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of the leaves of Jasminum cuspidatum...

  20. Thermodynamics-based Metabolite Sensitivity Analysis in metabolic networks.

    Science.gov (United States)

    Kiparissides, A; Hatzimanikatis, V

    2017-01-01

    The increasing availability of large metabolomics datasets enhances the need for computational methodologies that can organize the data in a way that can lead to the inference of meaningful relationships. Knowledge of the metabolic state of a cell and how it responds to various stimuli and extracellular conditions can offer significant insight in the regulatory functions and how to manipulate them. Constraint based methods, such as Flux Balance Analysis (FBA) and Thermodynamics-based flux analysis (TFA), are commonly used to estimate the flow of metabolites through genome-wide metabolic networks, making it possible to identify the ranges of flux values that are consistent with the studied physiological and thermodynamic conditions. However, unless key intracellular fluxes and metabolite concentrations are known, constraint-based models lead to underdetermined problem formulations. This lack of information propagates as uncertainty in the estimation of fluxes and basic reaction properties such as the determination of reaction directionalities. Therefore, knowledge of which metabolites, if measured, would contribute the most to reducing this uncertainty can significantly improve our ability to define the internal state of the cell. In the present work we combine constraint based modeling, Design of Experiments (DoE) and Global Sensitivity Analysis (GSA) into the Thermodynamics-based Metabolite Sensitivity Analysis (TMSA) method. TMSA ranks metabolites comprising a metabolic network based on their ability to constrain the gamut of possible solutions to a limited, thermodynamically consistent set of internal states. TMSA is modular and can be applied to a single reaction, a metabolic pathway or an entire metabolic network. This is, to our knowledge, the first attempt to use metabolic modeling in order to provide a significance ranking of metabolites to guide experimental measurements.

  1. ANSI/ASHRAE/IESNA Standard 90.1-2010 Preliminary Determination Quantitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Liu, Bing; Rosenberg, Michael I.

    2010-11-01

    The United States (U.S.) Department of Energy (DOE) conducted a preliminary quantitative analysis to assess whether buildings constructed according to the requirements of the American National Standards Institute (ANSI)/American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE)/Illuminating Engineering Society of North America (IESNA) Standard 90.1-2010 (ASHRAE Standard 90.1-2010, Standard 90.1-2010, or 2010 edition) would result in energy savings compared with buildings constructed to ANSI/ASHRAE/IESNA Standard 90.1-2007(ASHRAE Standard 90.1-2007, Standard 90.1-2007, or 2007 edition). The preliminary analysis considered each of the 109 addenda to ASHRAE Standard 90.1-2007 that were included in ASHRAE Standard 90.1-2010. All 109 addenda processed by ASHRAE in the creation of Standard 90.1-2010 from Standard 90.1-2007 were reviewed by DOE, and their combined impact on a suite of 16 building prototype models in 15 ASHRAE climate zones was considered. Most addenda were deemed to have little quantifiable impact on building efficiency for the purpose of DOE’s preliminary determination. However, out of the 109 addenda, 34 were preliminarily determined to have measureable and quantifiable impact.

  2. Preliminary phytochemical analysis and DPPH free radical scavenging activity of Trewia nudiflora Linn. roots and leaves.

    Science.gov (United States)

    Balakrishnan, N; Srivastava, Mayank; Tiwari, Pallavi

    2013-11-01

    Oxidative stress is one of the major causative factors of many chronic and degenerative diseases. Plants have been used in traditional medicine in different parts of world for thousands of years and continue to provide new remedies for human kind. The present study was to investigate the preliminary phytochemical analysis of various extracts of roots and leaves of Trewia nudiflora (Euphorbiaceae) and antioxidant activity by 1,1,diphenyl-2-picryl hydrazyl (DPPH) radical scavenging method. The preliminary phytochemical screening showed the presence of several phytochemicals including alkaloids, glycosides, flavonoids, steroids, phenolic compounds and tannins. The ethanol and aqueous extracts of roots and leaves of Trewia nudiflora showed significant antioxidant activity compared to standard drug ascorbic acid.

  3. CONSTRUCTION OF THE CHINESE LEARNERS' PARALLEL CORPUS OF JAPANESE AND ITS PRELIMINARY ANALYSIS

    Directory of Open Access Journals (Sweden)

    Masatake Dantsuji

    2004-01-01

    Full Text Available This study aims to introduce the project to construct the Chinese learners' corpus (LC of Japanese at Dalian University of Technology (DUT, and detail the LC construction, development of DUT Corpus Linguistics Tools, and contribution to the education of Japanese as a second language. The outstanding characteristic of the LC is its parallel form with learners' Japanese texts and their Chinese translation, which enables us to make comprehensive analysis of the influence of Chinese (L1 to Japanese (L2. We have made a preliminary analysis of the errors contained.

  4. Preliminary Design and Analysis of the ARES Atmospheric Flight Vehicle Thermal Control System

    Science.gov (United States)

    Gasbarre, J. F.; Dillman, R. A.

    2003-01-01

    The Aerial Regional-scale Environmental Survey (ARES) is a proposed 2007 Mars Scout Mission that will be the first mission to deploy an atmospheric flight vehicle (AFV) on another planet. This paper will describe the preliminary design and analysis of the AFV thermal control system for its flight through the Martian atmosphere and also present other analyses broadening the scope of that design to include other phases of the ARES mission. Initial analyses are discussed and results of trade studies are presented which detail the design process for AFV thermal control. Finally, results of the most recent AFV thermal analysis are shown and the plans for future work are discussed.

  5. LSENS - GENERAL CHEMICAL KINETICS AND SENSITIVITY ANALYSIS CODE

    Science.gov (United States)

    Bittker, D. A.

    1994-01-01

    LSENS has been developed for solving complex, homogeneous, gas-phase, chemical kinetics problems. The motivation for the development of this program is the continuing interest in developing detailed chemical reaction mechanisms for complex reactions such as the combustion of fuels and pollutant formation and destruction. A reaction mechanism is the set of all elementary chemical reactions that are required to describe the process of interest. Mathematical descriptions of chemical kinetics problems constitute sets of coupled, nonlinear, first-order ordinary differential equations (ODEs). The number of ODEs can be very large because of the numerous chemical species involved in the reaction mechanism. Further complicating the situation are the many simultaneous reactions needed to describe the chemical kinetics of practical fuels. For example, the mechanism describing the oxidation of the simplest hydrocarbon fuel, methane, involves over 25 species participating in nearly 100 elementary reaction steps. Validating a chemical reaction mechanism requires repetitive solutions of the governing ODEs for a variety of reaction conditions. Analytical solutions to the systems of ODEs describing chemistry are not possible, except for the simplest cases, which are of little or no practical value. Consequently, there is a need for fast and reliable numerical solution techniques for chemical kinetics problems. In addition to solving the ODEs describing chemical kinetics, it is often necessary to know what effects variations in either initial condition values or chemical reaction mechanism parameters have on the solution. Such a need arises in the development of reaction mechanisms from experimental data. The rate coefficients are often not known with great precision and in general, the experimental data are not sufficiently detailed to accurately estimate the rate coefficient parameters. The development of a reaction mechanism is facilitated by a systematic sensitivity analysis

  6. GPU-based Integration with Application in Sensitivity Analysis

    Science.gov (United States)

    Atanassov, Emanouil; Ivanovska, Sofiya; Karaivanova, Aneta; Slavov, Dimitar

    2010-05-01

    The presented work is an important part of the grid application MCSAES (Monte Carlo Sensitivity Analysis for Environmental Studies) which aim is to develop an efficient Grid implementation of a Monte Carlo based approach for sensitivity studies in the domains of Environmental modelling and Environmental security. The goal is to study the damaging effects that can be caused by high pollution levels (especially effects on human health), when the main modeling tool is the Danish Eulerian Model (DEM). Generally speaking, sensitivity analysis (SA) is the study of how the variation in the output of a mathematical model can be apportioned to, qualitatively or quantitatively, different sources of variation in the input of a model. One of the important classes of methods for Sensitivity Analysis are Monte Carlo based, first proposed by Sobol, and then developed by Saltelli and his group. In MCSAES the general Saltelli procedure has been adapted for SA of the Danish Eulerian model. In our case we consider as factors the constants determining the speeds of the chemical reactions in the DEM and as output a certain aggregated measure of the pollution. Sensitivity simulations lead to huge computational tasks (systems with up to 4 × 109 equations at every time-step, and the number of time-steps can be more than a million) which motivates its grid implementation. MCSAES grid implementation scheme includes two main tasks: (i) Grid implementation of the DEM, (ii) Grid implementation of the Monte Carlo integration. In this work we present our new developments in the integration part of the application. We have developed an algorithm for GPU-based generation of scrambled quasirandom sequences which can be combined with the CPU-based computations related to the SA. Owen first proposed scrambling of Sobol sequence through permutation in a manner that improves the convergence rates. Scrambling is necessary not only for error analysis but for parallel implementations. Good scrambling is

  7. Global in Time Analysis and Sensitivity Analysis for the Reduced NS- α Model of Incompressible Flow

    Science.gov (United States)

    Rebholz, Leo; Zerfas, Camille; Zhao, Kun

    2017-09-01

    We provide a detailed global in time analysis, and sensitivity analysis and testing, for the recently proposed (by the authors) reduced NS- α model. We extend the known analysis of the model to the global in time case by proving it is globally well-posed, and also prove some new results for its long time treatment of energy. We also derive PDE system that describes the sensitivity of the model with respect to the filtering radius parameter, and prove it is well-posed. An efficient numerical scheme for the sensitivity system is then proposed and analyzed, and proven to be stable and optimally accurate. Finally, two physically meaningful test problems are simulated: channel flow past a cylinder (including lift and drag calculations) and turbulent channel flow with {Re_{τ}=590}. The numerical results reveal that sensitivity is created near boundaries, and thus this is where the choice of the filtering radius is most critical.

  8. Crystallization and preliminary crystallographic analysis of a family 43 β-d-xylosidase from Geobacillus stearothermophilus T-6

    Energy Technology Data Exchange (ETDEWEB)

    Brüx, Christian; Niefind, Karsten [Institute for Biochemistry, University of Cologne (Germany); Ben-David, Alon; Leon, Maya [Department of Biotechnology and Food Engineering and Institute of Catalysis Science and Technology, Technion-Israel Institute of Technology, Haifa (Israel); Shoham, Gil [Department of Inorganic Chemistry and The Laboratory for Structural Chemistry and Biology, The Hebrew University of Jerusalem, Jerusalem (Israel); Shoham, Yuval [Department of Biotechnology and Food Engineering and Institute of Catalysis Science and Technology, Technion-Israel Institute of Technology, Haifa (Israel); Schomburg, Dietmar, E-mail: d.schomburg@uni-koeln.de [Institute for Biochemistry, University of Cologne (Germany)

    2005-12-01

    The crystallization and preliminary X-ray analysis of a β-d-xylosidase from G. stearothermophilus T-6, a family 43 glycoside hydrolase, is described. Native and catalytic inactive mutants of the enzymes were crystallized in two different space groups, orthorhombic P2{sub 1}2{sub 1}2 and tetragonal P4{sub 1}2{sub 1}2 (or the enantiomorphic space group P4{sub 3}2{sub 1}2), using a sensitive cryoprotocol. The latter crystal form diffracted X-rays to a resolution of 2.2 Å. β-d-Xylosidases (EC 3.2.1.37) are hemicellulases that cleave single xylose units from the nonreducing end of xylooligomers. In this study, the crystallization and preliminary X-ray analysis of a β-d-xylosidase from Geobacillus stearothermophilus T-6 (XynB3), a family 43 glycoside hydrolase, is described. XynB3 is a 535-amino-acid protein with a calculated molecular weight of 61 891 Da. Purified recombinant native and catalytic inactive mutant proteins were crystallized and cocrystallized with xylobiose in two different space groups, P2{sub 1}2{sub 1}2 (unit-cell parameters a = 98.32, b = 99.36, c = 258.64 Å) and P4{sub 1}2{sub 1}2 (or the enantiomorphic space group P4{sub 3}2{sub 1}2; unit-cell parameters a = b = 140.15, c = 233.11 Å), depending on the detergent. Transferring crystals to cryoconditions required a very careful protocol. Orthorhombic crystals diffract to 2.5 Å and tetragonal crystals to 2.2 Å.

  9. Robust and sensitive analysis of mouse knockout phenotypes.

    Directory of Open Access Journals (Sweden)

    Natasha A Karp

    Full Text Available A significant challenge of in-vivo studies is the identification of phenotypes with a method that is robust and reliable. The challenge arises from practical issues that lead to experimental designs which are not ideal. Breeding issues, particularly in the presence of fertility or fecundity problems, frequently lead to data being collected in multiple batches. This problem is acute in high throughput phenotyping programs. In addition, in a high throughput environment operational issues lead to controls not being measured on the same day as knockouts. We highlight how application of traditional methods, such as a Student's t-Test or a 2-way ANOVA, in these situations give flawed results and should not be used. We explore the use of mixed models using worked examples from Sanger Mouse Genome Project focusing on Dual-Energy X-Ray Absorptiometry data for the analysis of mouse knockout data and compare to a reference range approach. We show that mixed model analysis is more sensitive and less prone to artefacts allowing the discovery of subtle quantitative phenotypes essential for correlating a gene's function to human disease. We demonstrate how a mixed model approach has the additional advantage of being able to include covariates, such as body weight, to separate effect of genotype from these covariates. This is a particular issue in knockout studies, where body weight is a common phenotype and will enhance the precision of assigning phenotypes and the subsequent selection of lines for secondary phenotyping. The use of mixed models with in-vivo studies has value not only in improving the quality and sensitivity of the data analysis but also ethically as a method suitable for small batches which reduces the breeding burden of a colony. This will reduce the use of animals, increase throughput, and decrease cost whilst improving the quality and depth of knowledge gained.

  10. Multidisciplinary High-Fidelity Analysis and Optimization of Aerospace Vehicles. Part 2; Preliminary Results

    Science.gov (United States)

    Walsh, J. L.; Weston, R. P.; Samareh, J. A.; Mason, B. H.; Green, L. L.; Biedron, R. T.

    2000-01-01

    An objective of the High Performance Computing and Communication Program at the NASA Langley Research Center is to demonstrate multidisciplinary shape and sizing optimization of a complete aerospace vehicle configuration by using high-fidelity finite-element structural analysis and computational fluid dynamics aerodynamic analysis in a distributed, heterogeneous computing environment that includes high performance parallel computing. A software system has been designed and implemented to integrate a set of existing discipline analysis codes, some of them computationally intensive, into a distributed computational environment for the design of a high-speed civil transport configuration. The paper describes both the preliminary results from implementing and validating the multidisciplinary analysis and the results from an aerodynamic optimization. The discipline codes are integrated by using the Java programming language and a Common Object Request Broker Architecture compliant software product. A companion paper describes the formulation of the multidisciplinary analysis and optimization system.

  11. Extending 'Deep Blue' aerosol retrieval coverage to cases of absorbing aerosols above clouds: sensitivity analysis and first case studies

    Energy Technology Data Exchange (ETDEWEB)

    Sayer, Andrew M.; Hsu, C.; Bettenhausen, Corey; Lee, Jae N.; Redemann, Jens; Schmid, Beat; Shinozuka, Yohei

    2016-05-07

    Cases of absorbing aerosols above clouds (AAC), such as smoke or mineral dust, are omitted from most routinely-processed space-based aerosol optical depth (AOD) data products, including those from the Moderate Resolution Imaging Spectroradiometer (MODIS). This study presents a sensitivity analysis and preliminary algorithm to retrieve above-cloud AOD and liquid cloud optical depth (COD) for AAC cases from MODIS or similar

  12. Dynamic global sensitivity analysis in bioreactor networks for bioethanol production.

    Science.gov (United States)

    Ochoa, M P; Estrada, V; Di Maggio, J; Hoch, P M

    2016-01-01

    Dynamic global sensitivity analysis (GSA) was performed for three different dynamic bioreactor models of increasing complexity: a fermenter for bioethanol production, a bioreactors network, where two types of bioreactors were considered: aerobic for biomass production and anaerobic for bioethanol production and a co-fermenter bioreactor, to identify the parameters that most contribute to uncertainty in model outputs. Sobol's method was used to calculate time profiles for sensitivity indices. Numerical results have shown the time-variant influence of uncertain parameters on model variables. Most influential model parameters have been determined. For the model of the bioethanol fermenter, μmax (maximum growth rate) and Ks (half-saturation constant) are the parameters with largest contribution to model variables uncertainty; in the bioreactors network, the most influential parameter is μmax,1 (maximum growth rate in bioreactor 1); whereas λ (glucose-to-total sugars concentration ratio in the feed) is the most influential parameter over all model variables in the co-fermentation bioreactor.

  13. A Sensitivity Analysis Approach to Identify Key Environmental Performance Factors

    Directory of Open Access Journals (Sweden)

    Xi Yu

    2014-01-01

    Full Text Available Life cycle assessment (LCA is widely used in design phase to reduce the product’s environmental impacts through the whole product life cycle (PLC during the last two decades. The traditional LCA is restricted to assessing the environmental impacts of a product and the results cannot reflect the effects of changes within the life cycle. In order to improve the quality of ecodesign, it is a growing need to develop an approach which can reflect the changes between the design parameters and product’s environmental impacts. A sensitivity analysis approach based on LCA and ecodesign is proposed in this paper. The key environmental performance factors which have significant influence on the products’ environmental impacts can be identified by analyzing the relationship between environmental impacts and the design parameters. Users without much environmental knowledge can use this approach to determine which design parameter should be first considered when (redesigning a product. A printed circuit board (PCB case study is conducted; eight design parameters are chosen to be analyzed by our approach. The result shows that the carbon dioxide emission during the PCB manufacture is highly sensitive to the area of PCB panel.

  14. Ensemble Solar Forecasting Statistical Quantification and Sensitivity Analysis: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, WanYin; Zhang, Jie; Florita, Anthony; Hodge, Bri-Mathias; Lu, Siyuan; Hamann, Hendrik F.; Sun, Qian; Lehman, Brad

    2015-12-08

    Uncertainties associated with solar forecasts present challenges to maintain grid reliability, especially at high solar penetrations. This study aims to quantify the errors associated with the day-ahead solar forecast parameters and the theoretical solar power output for a 51-kW solar power plant in a utility area in the state of Vermont, U.S. Forecasts were generated by three numerical weather prediction (NWP) models, including the Rapid Refresh, the High Resolution Rapid Refresh, and the North American Model, and a machine-learning ensemble model. A photovoltaic (PV) performance model was adopted to calculate theoretical solar power generation using the forecast parameters (e.g., irradiance, cell temperature, and wind speed). Errors of the power outputs were quantified using statistical moments and a suite of metrics, such as the normalized root mean squared error (NRMSE). In addition, the PV model's sensitivity to different forecast parameters was quantified and analyzed. Results showed that the ensemble model yielded forecasts in all parameters with the smallest NRMSE. The NRMSE of solar irradiance forecasts of the ensemble NWP model was reduced by 28.10% compared to the best of the three NWP models. Further, the sensitivity analysis indicated that the errors of the forecasted cell temperature attributed only approximately 0.12% to the NRMSE of the power output as opposed to 7.44% from the forecasted solar irradiance.

  15. Sensitivity analysis on parameter changes in underground mine ventilation systems

    Institute of Scientific and Technical Information of China (English)

    LI Gary; KOCSIS Charles; HARDCASTLE Steve

    2011-01-01

    A more efficient mine ventilation system,the ventilation-on-demand (VOD) system,has been proposed and tested in Canadian mines recently.In order to supply the required air volumes to the production areas of a mine,operators need to know the cause and effect of any changes requested from the VOD system.The sensitivity analysis is developed through generating a cause and effect matrix of sensitivity factors on given parameter changes in a ventilation system.This new utility,which was incorporated in the 3D-CANVENT mine ventilation simulator,is able to predict the airflow distributions in a ventilation network when underground conditions and ventilation controls are changed.For a primary ventilation system,the software can determine the optimal operating speed of the main fans to satisfy the airflow requirements in underground workings without necessarily using booster fans and regulators locally.An optimized fan operating speed time-table would assure variable demand-based fresh air delivery to the production areas effectively,while generating significant savings in energy consumption and operating cost.

  16. Sensitivity analysis for high accuracy proximity effect correction

    Science.gov (United States)

    Thrun, Xaver; Browning, Clyde; Choi, Kang-Hoon; Figueiro, Thiago; Hohle, Christoph; Saib, Mohamed; Schiavone, Patrick; Bartha, Johann W.

    2015-10-01

    A sensitivity analysis (SA) algorithm was developed and tested to comprehend the influences of different test pattern sets on the calibration of a point spread function (PSF) model with complementary approaches. Variance-based SA is the method of choice. It allows attributing the variance of the output of a model to the sum of variance of each input of the model and their correlated factors.1 The objective of this development is increasing the accuracy of the resolved PSF model in the complementary technique through the optimization of test pattern sets. Inscale® from Aselta Nanographics is used to prepare the various pattern sets and to check the consequences of development. Fraunhofer IPMS-CNT exposed the prepared data and observed those to visualize the link of sensitivities between the PSF parameters and the test pattern. First, the SA can assess the influence of test pattern sets for the determination of PSF parameters, such as which PSF parameter is affected on the employments of certain pattern. Secondly, throughout the evaluation, the SA enhances the precision of PSF through the optimization of test patterns. Finally, the developed algorithm is able to appraise what ranges of proximity effect correction is crucial on which portion of a real application pattern in the electron beam exposure.

  17. Sensitivity Analysis in a Complex Marine Ecological Model

    Directory of Open Access Journals (Sweden)

    Marcos D. Mateus

    2015-05-01

    Full Text Available Sensitivity analysis (SA has long been recognized as part of best practices to assess if any particular model can be suitable to inform decisions, despite its uncertainties. SA is a commonly used approach for identifying important parameters that dominate model behavior. As such, SA address two elementary questions in the modeling exercise, namely, how sensitive is the model to changes in individual parameter values, and which parameters or associated processes have more influence on the results. In this paper we report on a local SA performed on a complex marine biogeochemical model that simulates oxygen, organic matter and nutrient cycles (N, P and Si in the water column, and well as the dynamics of biological groups such as producers, consumers and decomposers. SA was performed using a “one at a time” parameter perturbation method, and a color-code matrix was developed for result visualization. The outcome of this study was the identification of key parameters influencing model performance, a particularly helpful insight for the subsequent calibration exercise. Also, the color-code matrix methodology proved to be effective for a clear identification of the parameters with most impact on selected variables of the model.

  18. Ensemble Solar Forecasting Statistical Quantification and Sensitivity Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, WanYin; Zhang, Jie; Florita, Anthony; Hodge, Bri-Mathias; Lu, Siyuan; Hamann, Hendrik F.; Sun, Qian; Lehman, Brad

    2015-10-02

    Uncertainties associated with solar forecasts present challenges to maintain grid reliability, especially at high solar penetrations. This study aims to quantify the errors associated with the day-ahead solar forecast parameters and the theoretical solar power output for a 51-kW solar power plant in a utility area in the state of Vermont, U.S. Forecasts were generated by three numerical weather prediction (NWP) models, including the Rapid Refresh, the High Resolution Rapid Refresh, and the North American Model, and a machine-learning ensemble model. A photovoltaic (PV) performance model was adopted to calculate theoretical solar power generation using the forecast parameters (e.g., irradiance, cell temperature, and wind speed). Errors of the power outputs were quantified using statistical moments and a suite of metrics, such as the normalized root mean squared error (NRMSE). In addition, the PV model's sensitivity to different forecast parameters was quantified and analyzed. Results showed that the ensemble model yielded forecasts in all parameters with the smallest NRMSE. The NRMSE of solar irradiance forecasts of the ensemble NWP model was reduced by 28.10% compared to the best of the three NWP models. Further, the sensitivity analysis indicated that the errors of the forecasted cell temperature attributed only approximately 0.12% to the NRMSE of the power output as opposed to 7.44% from the forecasted solar irradiance.

  19. EH AND S ANALYSIS OF DYE-SENSITIZED PHOTOVOLTAIC SOLAR CELL PRODUCTION.

    Energy Technology Data Exchange (ETDEWEB)

    BOWERMAN,B.; FTHENAKIS,V.

    2001-10-01

    Photovoltaic solar cells based on a dye-sensitized nanocrystalline titanium dioxide photoelectrode have been researched and reported since the early 1990's. Commercial production of dye-sensitized photovoltaic solar cells has recently been reported in Australia. In this report, current manufacturing methods are described, and estimates are made of annual chemical use and emissions during production. Environmental, health and safety considerations for handling these materials are discussed. This preliminary EH and S evaluation of dye-sensitized titanium dioxide solar cells indicates that some precautions will be necessary to mitigate hazards that could result in worker exposure. Additional information required for a more complete assessment is identified.

  20. Waste Feed Delivery System Phase 1 Preliminary RAM Analysis [SEC 1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    DYKES, A.A.

    2000-10-11

    This report presents the updated results of the preliminary reliability, availability, and maintainability (RAM) analysis of selected waste feed delivery (WFD) operations to be performed by the Tank Farm Contractor (TFC) during Phase I activities in support of the Waste Treatment and Immobilization Plant (WTP). For planning purposes, waste feed tanks are being divided into five classes in accordance with the type of waste in each tank and the activities required to retrieve, qualify, and transfer waste feed. This report reflects the baseline design and operating concept, as of the beginning of Fiscal Year 2000, for the delivery of feed from three of these classes, represented by source tanks 241-AN-102, 241-AZ-101 and 241-AN-105. The preliminary RAM analysis quantifies the potential schedule delay associated with operations and maintenance (OBM) field activities needed to accomplish these operations. The RAM analysis is preliminary because the system design, process definition, and activity planning are in a state of evolution. The results are being used to support the continuing development of an O&M Concept tailored to the unique requirements of the WFD Program, which is being documented in various volumes of the Waste Feed Delivery Technical Basis (Carlson. 1999, Rasmussen 1999, and Orme 2000). The waste feed provided to the WTP must: (1) meet limits for chemical and radioactive constituents based on pre-established compositional envelopes (i.e., feed quality); (2) be in acceptable quantities within a prescribed sequence to meet feed quantities; and (3) meet schedule requirements (i.e., feed timing). In the absence of new criteria related to acceptable schedule performance due to the termination of the TWRS Privatization Contract, the original criteria from the Tank Waste Remediation System (77443s) Privatization Contract (DOE 1998) will continue to be used for this analysis.

  1. High-energy resolution μ-XRF analysis by position sensitive spectrometer

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    With a high-energy resolution micro-X-ray fluorescence (μ-XRF) analysis setup, which basically consists of an X-ray microbeam formed by an X-ray focusing lens combined with an X-ray apparatus and a wavelength dispersive position sensitive spectrometer with a flat crystal (PSS), preliminary results have been obtained. The counting rate of the analyzed element linearly increased with the power of X-ray apparatus, and the energy resolution, full width of half maximum (FWHM) of Ka lines of Ti and Cr reached 16.6 and 23.6 eV, respectively. The Cr Kb and Mn Ka lines in a sample of stainless steel could clearly be resolved. The above-mentioned results are also compared with those obtained by synchrotron radiation light microbeam combined with the PSS. The facts show that the high-energy resolution element analysis is feasible by using the setup. Moreover, problems for the setup and the ways to resolve them are discussed as well.

  2. Sensitivity Analysis of Differential-Algebraic Equations and Partial Differential Equations

    Energy Technology Data Exchange (ETDEWEB)

    Petzold, L; Cao, Y; Li, S; Serban, R

    2005-08-09

    Sensitivity analysis generates essential information for model development, design optimization, parameter estimation, optimal control, model reduction and experimental design. In this paper we describe the forward and adjoint methods for sensitivity analysis, and outline some of our recent work on theory, algorithms and software for sensitivity analysis of differential-algebraic equation (DAE) and time-dependent partial differential equation (PDE) systems.

  3. Space Shuttle Orbiter entry guidance and control system sensitivity analysis

    Science.gov (United States)

    Stone, H. W.; Powell, R. W.

    1976-01-01

    An approach has been developed to determine the guidance and control system sensitivity to off-nominal aerodynamics for the Space Shuttle Orbiter during entry. This approach, which uses a nonlinear six-degree-of-freedom interactive, digital simulation, has been applied to both the longitudinal and lateral-directional axes for a portion of the orbiter entry. Boundary values for each of the aerodynamic parameters have been identified, the key parameters have been determined, and system modifications that will increase system tolerance to off-nominal aerodynamics have been recommended. The simulations were judged by specified criteria and the performance was evaluated by use of key dependent variables. The analysis is now being expanded to include the latest shuttle guidance and control systems throughout the entry speed range.

  4. Sensitivity analysis for oblique incidence reflectometry using Monte Carlo simulations

    DEFF Research Database (Denmark)

    Kamran, Faisal; Andersen, Peter E.

    2015-01-01

    Oblique incidence reflectometry has developed into an effective, noncontact, and noninvasive measurement technology for the quantification of both the reduced scattering and absorption coefficients of a sample. The optical properties are deduced by analyzing only the shape of the reflectance...... profiles. This article presents a sensitivity analysis of the technique in turbid media. Monte Carlo simulations are used to investigate the technique and its potential to distinguish the small changes between different levels of scattering. We present various regions of the dynamic range of optical...... properties in which system demands vary to be able to detect subtle changes in the structure of the medium, translated as measured optical properties. Effects of variation in anisotropy are discussed and results presented. Finally, experimental data of milk products with different fat content are considered...

  5. A Multivariate Analysis of Extratropical Cyclone Environmental Sensitivity

    Science.gov (United States)

    Tierney, G.; Posselt, D. J.; Booth, J. F.

    2015-12-01

    The implications of a changing climate system include more than a simple temperature increase. A changing climate also modifies atmospheric conditions responsible for shaping the genesis and evolution of atmospheric circulations. In the mid-latitudes, the effects of climate change on extratropical cyclones (ETCs) can be expressed through changes in bulk temperature, horizontal and vertical temperature gradients (leading to changes in mean state winds) as well as atmospheric moisture content. Understanding how these changes impact ETC evolution and dynamics will help to inform climate mitigation and adaptation strategies, and allow for better informed weather emergency planning. However, our understanding is complicated by the complex interplay between a variety of environmental influences, and their potentially opposing effects on extratropical cyclone strength. Attempting to untangle competing influences from a theoretical or observational standpoint is complicated by nonlinear responses to environmental perturbations and a lack of data. As such, numerical models can serve as a useful tool for examining this complex issue. We present results from an analysis framework that combines the computational power of idealized modeling with the statistical robustness of multivariate sensitivity analysis. We first establish control variables, such as baroclinicity, bulk temperature, and moisture content, and specify a range of values that simulate possible changes in a future climate. The Weather Research and Forecasting (WRF) model serves as the link between changes in climate state and ETC relevant outcomes. A diverse set of output metrics (e.g., sea level pressure, average precipitation rates, eddy kinetic energy, and latent heat release) facilitates examination of storm dynamics, thermodynamic properties, and hydrologic cycles. Exploration of the multivariate sensitivity of ETCs to changes in control parameters space is performed via an ensemble of WRF runs coupled with

  6. Uncertainty and sensitivity analysis for photovoltaic system modeling.

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Clifford W.; Pohl, Andrew Phillip; Jordan, Dirk

    2013-12-01

    We report an uncertainty and sensitivity analysis for modeling DC energy from photovoltaic systems. We consider two systems, each comprised of a single module using either crystalline silicon or CdTe cells, and located either at Albuquerque, NM, or Golden, CO. Output from a PV system is predicted by a sequence of models. Uncertainty in the output of each model is quantified by empirical distributions of each model's residuals. We sample these distributions to propagate uncertainty through the sequence of models to obtain an empirical distribution for each PV system's output. We considered models that: (1) translate measured global horizontal, direct and global diffuse irradiance to plane-of-array irradiance; (2) estimate effective irradiance from plane-of-array irradiance; (3) predict cell temperature; and (4) estimate DC voltage, current and power. We found that the uncertainty in PV system output to be relatively small, on the order of 1% for daily energy. Four alternative models were considered for the POA irradiance modeling step; we did not find the choice of one of these models to be of great significance. However, we observed that the POA irradiance model introduced a bias of upwards of 5% of daily energy which translates directly to a systematic difference in predicted energy. Sensitivity analyses relate uncertainty in the PV system output to uncertainty arising from each model. We found that the residuals arising from the POA irradiance and the effective irradiance models to be the dominant contributors to residuals for daily energy, for either technology or location considered. This analysis indicates that efforts to reduce the uncertainty in PV system output should focus on improvements to the POA and effective irradiance models.

  7. Sensitivity analysis on various parameters for lattice analysis of DUPIC fuel with WIMS-AECL code

    Energy Technology Data Exchange (ETDEWEB)

    Roh, Gyu Hong; Choi, Hang Bok; Park, Jee Won [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1997-12-31

    The code WIMS-AECL has been used for the lattice analysis of DUPIC fuel. The lattice parameters calculated by the code is sensitive to the choice of number of parameters, such as the number of tracking lines, number of condensed groups, mesh spacing in the moderator region, other parameters vital to the calculation of probabilities and burnup analysis. We have studied this sensitivity with respect to these parameters and recommend their proper values which are necessary for carrying out the lattice analysis of DUPIC fuel.

  8. Sensitivity analysis, approximate analysis, and design optimization for internal and external viscous flows

    Science.gov (United States)

    Taylor, Arthur C., III; Hou, Gene W.; Korivi, Vamshi M.

    1991-01-01

    A gradient-based design optimization strategy for practical aerodynamic design applications is presented, which uses the 2D thin-layer Navier-Stokes equations. The strategy is based on the classic idea of constructing different modules for performing the major tasks such as function evaluation, function approximation and sensitivity analysis, mesh regeneration, and grid sensitivity analysis, all driven and controlled by a general-purpose design optimization program. The accuracy of aerodynamic shape sensitivity derivatives is validated on two viscous test problems: internal flow through a double-throat nozzle and external flow over a NACA 4-digit airfoil. A significant improvement in aerodynamic performance has been achieved in both cases. Particular attention is given to a consistent treatment of the boundary conditions in the calculation of the aerodynamic sensitivity derivatives for the classic problems of external flow over an isolated lifting airfoil on 'C' or 'O' meshes.

  9. Preliminary analysis of Alvito-Odivelas reservoir system operation under climate change scenarios

    OpenAIRE

    2008-01-01

    The present study provides a preliminary analysis of the impact of climate change on a water resources system of Alentejo region in the South of Portugal. Regional climate model HadRM3P forced by the Global Circulation Model HadAM3P A2 of the Hadley Centre, is used to derive temperature and precipitation data, which in turn is used as input to hydrological model (SHETRAN) for simulation of future streamflow. Dynamic programming based models are used for operation of reservoir system in order ...

  10. Stock assessment of Haliporoides triarthrus (Fam. Solenoceridae) off Mozambique: a preliminary analysis

    OpenAIRE

    Torstensen, E.; Pacule, H.

    1992-01-01

    The pink shrimp, Haliporoides triarthrus, is an important species in the deep-water shrimp fishery in Mozambique. Total catches are in the range of 1,500 to 2,700 tons, with the pink shrimp accounting for 70-90%. Estimates of growth parameters and of natural mortality are used for a preliminary assessment of the fishery, based on length-structured virtual population analysis and yield-per-recruit analyses. With an arbitrarily chosen terminal fishing mortality F, the results indicate a situati...

  11. Preliminary Analysis of Liquid Metal MHD Pressure Drop in the Blanket for the FDS

    Institute of Scientific and Technical Information of China (English)

    王红艳; 吴宜灿; 何晓雄

    2002-01-01

    Preliminary analysis and calculation of liquid metal Li17Pb83 magnetohydrodynamic (MHD) pressure drop in the blanket for the FDS have been presented to evaluate the significance of MHD effects on the thermal-hydraulic design of the blanket. To decrease the liquid metal MHD pressure drop, Al2O3 is applied as an electronically insulated coating onto the inner surface of the ducts. The requirement for the insulated coating to reduce the additional leakage pressure drop caused by coating imperfections has been analyzed. Finally, the total liquid metal MHD pressure drop and magnetic pump power in the FDS blanket have been given.

  12. Preliminary performance analysis of a transverse flow spectrally selective two-slab packed bed volumetric receiver

    CSIR Research Space (South Africa)

    Roos, TH

    2016-05-01

    Full Text Available stream_source_info Roos_2016_ABSTRACT.pdf.txt stream_content_type text/plain stream_size 2694 Content-Encoding UTF-8 stream_name Roos_2016_ABSTRACT.pdf.txt Content-Type text/plain; charset=UTF-8 21st SolarPACES... International Conference (SolarPACES 2015), 13-16 October 2015 Preliminary Performance Analysis of a Transverse Flow Spectrally Selective Two-slab Packed Bed Volumetric Receiver Thomas H. Roos1, a) and Thomas M. Harms2, b) 1Aeronautical Systems...

  13. Preliminary Report: Analysis of the baseline study on the prevalence of Salmonella in laying hen flocks of Gallus gallus

    DEFF Research Database (Denmark)

    Hald, Tine

    This is a preliminary report on the analysis of the Community-wide baseline study to estimate the prevalence of Salmonella in laying hen flocks. It is being published pending the full analysis of the entire dataset from the baseline study. The report contains the elements necessary for the establ......This is a preliminary report on the analysis of the Community-wide baseline study to estimate the prevalence of Salmonella in laying hen flocks. It is being published pending the full analysis of the entire dataset from the baseline study. The report contains the elements necessary...

  14. Spatial risk assessment for critical network infrastructure using sensitivity analysis

    Institute of Scientific and Technical Information of China (English)

    Michael M·derl; Wolfgang Rauch

    2011-01-01

    The presented spatial risk assessment method allows for managing critical network infrastructure in urban areas under abnormal and future conditions caused e.g.,by terrorist attacks,infrastructure deterioration or climate change.For the spatial risk assessment,vulnerability maps for critical network infrastructure are merged with hazard maps for an interfering process.Vulnerability maps are generated using a spatial sensitivity analysis of network transport models to evaluate performance decrease under investigated thread scenarios.Thereby parameters are varied according to the specific impact of a particular threat scenario.Hazard maps are generated with a geographical information system using raster data of the same threat scenario derived from structured interviews and cluster analysis of events in the past.The application of the spatial risk assessment is exemplified by means of a case study for a water supply system,but the principal concept is applicable likewise to other critical network infrastructure.The aim of the approach is to help decision makers in choosing zones for preventive measures.

  15. Sensitivity analysis of geometric errors in additive manufacturing medical models.

    Science.gov (United States)

    Pinto, Jose Miguel; Arrieta, Cristobal; Andia, Marcelo E; Uribe, Sergio; Ramos-Grez, Jorge; Vargas, Alex; Irarrazaval, Pablo; Tejos, Cristian

    2015-03-01

    Additive manufacturing (AM) models are used in medical applications for surgical planning, prosthesis design and teaching. For these applications, the accuracy of the AM models is essential. Unfortunately, this accuracy is compromised due to errors introduced by each of the building steps: image acquisition, segmentation, triangulation, printing and infiltration. However, the contribution of each step to the final error remains unclear. We performed a sensitivity analysis comparing errors obtained from a reference with those obtained modifying parameters of each building step. Our analysis considered global indexes to evaluate the overall error, and local indexes to show how this error is distributed along the surface of the AM models. Our results show that the standard building process tends to overestimate the AM models, i.e. models are larger than the original structures. They also show that the triangulation resolution and the segmentation threshold are critical factors, and that the errors are concentrated at regions with high curvatures. Errors could be reduced choosing better triangulation and printing resolutions, but there is an important need for modifying some of the standard building processes, particularly the segmentation algorithms. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

  16. Lock Acquisition and Sensitivity Analysis of Advanced LIGO Interferometers

    Science.gov (United States)

    Martynov, Denis

    Laser interferometer gravitational wave observatory (LIGO) consists of two complex large-scale laser interferometers designed for direct detection of gravitational waves from distant astrophysical sources in the frequency range 10Hz - 5kHz. Direct detection of space-time ripples will support Einstein's general theory of relativity and provide invaluable information and new insight into physics of the Universe. The initial phase of LIGO started in 2002, and since then data was collected during the six science runs. Instrument sensitivity improved from run to run due to the effort of commissioning team. Initial LIGO has reached designed sensitivity during the last science run, which ended in October 2010. In parallel with commissioning and data analysis with the initial detector, LIGO group worked on research and development of the next generation of detectors. Major instrument upgrade from initial to advanced LIGO started in 2010 and lasted until 2014. This thesis describes results of commissioning work done at the LIGO Livingston site from 2013 until 2015 in parallel with and after the installation of the instrument. This thesis also discusses new techniques and tools developed at the 40m prototype including adaptive filtering, estimation of quantization noise in digital filters and design of isolation kits for ground seismometers. The first part of this thesis is devoted to the description of methods for bringing the interferometer into linear regime when collection of data becomes possible. States of longitudinal and angular controls of interferometer degrees of freedom during lock acquisition process and in low noise configuration are discussed in details. Once interferometer is locked and transitioned to low noise regime, instrument produces astrophysics data that should be calibrated to units of meters or strain. The second part of this thesis describes online calibration technique set up in both observatories to monitor the quality of the collected data in

  17. Sensitivity analysis of simulated SOA loadings using a variance-based statistical approach: SENSITIVITY ANALYSIS OF SOA

    Energy Technology Data Exchange (ETDEWEB)

    Shrivastava, Manish [Pacific Northwest National Laboratory, Richland Washington USA; Zhao, Chun [Pacific Northwest National Laboratory, Richland Washington USA; Easter, Richard C. [Pacific Northwest National Laboratory, Richland Washington USA; Qian, Yun [Pacific Northwest National Laboratory, Richland Washington USA; Zelenyuk, Alla [Pacific Northwest National Laboratory, Richland Washington USA; Fast, Jerome D. [Pacific Northwest National Laboratory, Richland Washington USA; Liu, Ying [Pacific Northwest National Laboratory, Richland Washington USA; Zhang, Qi [Department of Environmental Toxicology, University of California Davis, California USA; Guenther, Alex [Department of Earth System Science, University of California, Irvine California USA

    2016-04-08

    We investigate the sensitivity of secondary organic aerosol (SOA) loadings simulated by a regional chemical transport model to 7 selected tunable model parameters: 4 involving emissions of anthropogenic and biogenic volatile organic compounds, anthropogenic semi-volatile and intermediate volatility organics (SIVOCs), and NOx, 2 involving dry deposition of SOA precursor gases, and one involving particle-phase transformation of SOA to low volatility. We adopt a quasi-Monte Carlo sampling approach to effectively sample the high-dimensional parameter space, and perform a 250 member ensemble of simulations using a regional model, accounting for some of the latest advances in SOA treatments based on our recent work. We then conduct a variance-based sensitivity analysis using the generalized linear model method to study the responses of simulated SOA loadings to the tunable parameters. Analysis of SOA variance from all 250 simulations shows that the volatility transformation parameter, which controls whether particle-phase transformation of SOA from semi-volatile SOA to non-volatile is on or off, is the dominant contributor to variance of simulated surface-level daytime SOA (65% domain average contribution). We also split the simulations into 2 subsets of 125 each, depending on whether the volatility transformation is turned on/off. For each subset, the SOA variances are dominated by the parameters involving biogenic VOC and anthropogenic SIVOC emissions. Furthermore, biogenic VOC emissions have a larger contribution to SOA variance when the SOA transformation to non-volatile is on, while anthropogenic SIVOC emissions have a larger contribution when the transformation is off. NOx contributes less than 4.3% to SOA variance, and this low contribution is mainly attributed to dominance of intermediate to high NOx conditions throughout the simulated domain. The two parameters related to dry deposition of SOA precursor gases also have very low contributions to SOA variance

  18. Preliminary phytochemical screening, Antibacterial potential and GC-MS analysis of two medicinal plant extracts.

    Science.gov (United States)

    Vijayaram, Seerangaraj; Kannan, Suruli; Saravanan, Konda Mani; Vasantharaj, Seerangaraj; Sathiyavimal, Selvam; P, Palanisamy Senthilkumar

    2016-05-01

    The presence study was aimed to catalyze the primary metabolites and their confirmation by using GC-MS analysis and antibacterial potential of leaf extract of two important medicinal plant viz., Eucalyptus and Azadirachta indica. The antibacterial potential of the methanol leaf extract of the studied species was tested against Escherichia coli, Pseudomonas aeruginosa, Klebsiellap neumoniae, Streptococcus pyogens, Staphylococcus aureus using by agar well diffusion method. The higher zone of inhibition (16mm) was observed against the bacterium Pseudomonas aeruginosa at 100μl concentration of methanol leaf extract. Preliminary phytochemical analysis of studied species shows that presence of phytochemical compounds like steroids, phenolic compounds and flavonoids. GC-MS analysis confirms the occurrence of 20 different compounds in the methanol leaf extract of the both studied species.

  19. 1972 preliminary safety analysis report based on a conceptual design of a proposed repository in Kansas

    Energy Technology Data Exchange (ETDEWEB)

    Blomeke, J.O.

    1977-08-01

    This preliminary safety analysis report is based on a proposed Federal Repository at Lyons, Kansas, for receiving, handling, and depositing radioactive solid wastes in bedded salt during the remainder of this century. The safety analysis applies to a hypothetical site in central Kansas identical to the Lyons site, except that it is free of nearby salt solution-mining operations and bore holes that cannot be plugged to Repository specifications. This PSAR contains much information that also appears in the conceptual design report. Much of the geological-hydrological information was gathered in the Lyons area. This report is organized in 16 sections: considerations leading to the proposed Repository, design requirements and criteria, a description of the Lyons site and its environs, land improvements, support facilities, utilities, different impacts of Repository operations, safety analysis, design confirmation program, operational management, requirements for eventually decommissioning the facility, design criteria for protection from severe natural events, and the proposed program of experimental investigations. (DLC)

  20. Preliminary Cluster Analysis For Several Representatives Of Genus Kerivoula (Chiroptera: Vespertilionidae) in Borneo

    Science.gov (United States)

    Hasan, Noor Haliza; Abdullah, M. T.

    2008-01-01

    The aim of the study is to use cluster analysis on morphometric parameters within the genus Kerivoula to produce a dendrogram and to determine the suitability of this method to describe the relationship among species within this genus. A total of 15 adult male individuals from genus Kerivoula taken from sampling trips around Borneo and specimens kept at the zoological museum of Universiti Malaysia Sarawak were examined. A total of 27 characters using dental, skull and external body measurements were recorded. Clustering analysis illustrated the grouping and morphometric relationships between the species of this genus. It has clearly separated each species from each other despite the overlapping of measurements of some species within the genus. Cluster analysis provides an alternative approach to make a preliminary identification of a species.

  1. Preliminary Observations on Sensitivity and Specificity of Magnetization Transfer Asymmetry for Imaging Myelin of Rat Brain at High Field.

    Science.gov (United States)

    Kim, Jae-Woong; Choi, Jiye; Cho, Janggeun; Lee, Chulhyun; Jeon, Daejong; Park, Sung-Hong

    2015-01-01

    Magnetization transfer ratio (MTR) has been often used for imaging myelination. Despite its high sensitivity, the specificity of MTR to myelination is not high because tissues with no myelin such as muscle can also show high MTR. In this study, we propose a new magnetization transfer (MT) indicator, MT asymmetry (MTA), as a new method of myelin imaging. The experiments were performed on rat brain at 9.4 T. MTA revealed high signals in white matter and significantly low signals in gray matter and muscle, indicating that MTA has higher specificity than MTR. Demyelination and remyelination studies demonstrated that the sensitivity of MTA to myelination was as high as that of MTR. These experimental results indicate that MTA can be a good biomarker for imaging myelination. In addition, MTA images can be efficiently acquired with an interslice MTA method, which may accelerate clinical application of myelin imaging.

  2. Dynamic Simulation of Batch Polymerization Reactor and Sensitivity Analysis of Styrene Homopolymerization

    Directory of Open Access Journals (Sweden)

    S. Kuzmić

    2015-03-01

    Full Text Available In this work, dynamic simulations of a batch reactor in the process of styrene homopolymerization in a xylene solution initiated with two types of peroxide initiators, monofunctional and bifunctional, was carried out. The monofunctional peroxide initiator has wide industrial applications, while the bifunctional initiator in preliminary studies has shown some advantages, such as the production of polymers with homogeneous structure along with achieving high or even complete conversion of monomers. Additionally, the reaction time can be significantly reduced with no modification of the reactor system. Computer simulation was performed using ChemCAD software for simulation of the chemical process and its integrated modules CC-Polymer developed exclusively for the analysis and design of radical and step polymerization processes. This software package based on the previously developed very complex kinetic models predicts the basic structural properties of polymers such as molar mass and its distribution (dispersity, which directly determines the quality and use of the final product. Dependencies of monomer conversion and structural characteristics of the polymers on the polymerization time obtained by computer simulation were compared with the experimental data. The satisfactory tendencies and a relatively good agreement were accomplished regarding the end of polymerization for most of the examined conditions. Additionally, a sensitivity study for homopolymeric system initiated with diperoxide initiator was performed. The effects of monomer concentration, initiator concentration, temperature and reaction time on the rate of polymerization (monomer conversion and the main structural properties of polymers were examined.

  3. A rapid and sensitive technique for assessing exposure to VX via GC-MS-MS analysis.

    Science.gov (United States)

    McGuire, Jeffrey M; Byers, Christopher E; Hulet, Stanley W; Jakubowski, Edward M; Thomson, Sandra A

    2008-01-01

    A rapid and sensitive method for the determination of the chemical warfare agent VX in plasma taken from Göttingen minipigs has been developed using isotope-dilution gas chromatography-tandem mass spectrometry (GC-MS-MS). Chromatographic separation was achieved on a 5% diphenyl/95% dimethyl polysiloxane capillary column with a total run time of about 11 min. The analyte was detected using ammonia chemical ionization in the multiple reaction monitoring mode, following a simple extraction with 10% 2-propanol in hexane. A good linear relationship was obtained in the quantitative concentration range of 10 ng/mL to 1000 ng/mL (r(2) = 0.9998) with an average slope of 1.275 +/- 0.037 (n = 7), and an absolute detection limit of 0.4 pg on column. The average recovery for VX was 95% in saline in the concentration range of 50-100 ng/mL. The method was successfully applied to the analysis of VX in minipig plasma in a preliminary toxicokinetic study.

  4. Protein Profiling on Meglumine Antimoniate (Glucantime® Sensitive and Resistant L. tropica Isolates by 2- Dimentional Gel Electrophoresis: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    R Hadighi

    2009-02-01

    Full Text Available Background: Glucantime® is the first- line drug for the treatment of all forms of leishmaniasis. Unfortunately, the prevalence of parasites becoming resistant to Glucantime® is increasing in several parts of the world including Iran. As protein is the most important target for drugs in response to a variety of signals including drugs so, it seems expression protein patterns in sensitive and resistant Leishmania parasites could greatly help us about the mechanisms of responses to antileishmanial drugs. In this study, we used 2-dimentional gel electrophoresis (2-DE method to determine protein expression profiles between drug (Glucantime® sensitive and resistant Leishmania tropica isolated from Iranian an­throponotic cutaneous leishmaniasis (ACL patients."nMethods: We used from the two confirmed genetically of Glucantime® sensitive (Mash-4 and resistant (Mash-927 field strains of L. tropica, isolated from ACL patients in north eastern Iran. The two Leishmania isolates were cultured, promastigotes were harvested followed by protein extraction using TCA/Aceton to study protein profiling, 2-DE was done and gels stained with silver nitrate."nResults: At least 2236 distinct protein spots were detected. Twelve spots out of them, showed significant changes in expression in resistant compared to sensitive isolates. Of these, 11 protein spots were up- and one was down-regulated."nConclusions: This preliminary study has showed that a number of proteins differentially expressed in drug (Glucan­time® resistance L. tropica and probably the role of these proteins are increasing the parasite resistance against the drug and delay in cell death.

  5. The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum

    Energy Technology Data Exchange (ETDEWEB)

    Dobson, Renwick C. J., E-mail: rdobson@unimelb.edu.au; Atkinson, Sarah C. [Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010 (Australia); Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, Victoria 3010 (Australia); Gorman, Michael A. [St Vincents Institute, 9 Princes Street, Fitzroy, Victoria 3065 (Australia); Newman, Janet M. [CSIRO Division of Molecular and Health Technologies, 343 Royal Parade, Parkville, Victoria 3052 (Australia); Parker, Michael W. [Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010 (Australia); Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, Victoria 3010 (Australia); St Vincents Institute, 9 Princes Street, Fitzroy, Victoria 3065 (Australia); Perugini, Matthew A. [Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010 (Australia); Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Road, University of Melbourne, Parkville, Victoria 3010 (Australia)

    2008-03-01

    Dihydrodipicolinate synthase (DHDPS), an enzyme in the lysine-biosynthetic pathway, is a promising target for antibiotic development against pathogenic bacteria. Here, the expression, purification, crystallization and preliminary diffraction analysis of DHDPS from C. botulinum are reported. In recent years, dihydrodipicolinate synthase (DHDPS; EC 4.2.1.52) has received considerable attention from both mechanistic and structural viewpoints. This enzyme, which is part of the diaminopimelate pathway leading to lysine, couples (S)-aspartate-β-semialdehyde with pyruvate via a Schiff base to a conserved active-site lysine. In this paper, the expression, purification, crystallization and preliminary X-ray diffraction analysis of DHDPS from Clostridium botulinum, an important bacterial pathogen, are presented. The enzyme was crystallized in a number of forms, predominantly using PEG precipitants, with the best crystal diffracting to beyond 1.9 Å resolution and displaying P4{sub 2}2{sub 1}2 symmetry. The unit-cell parameters were a = b = 92.9, c = 60.4 Å. The crystal volume per protein weight (V{sub M}) was 2.07 Å{sup 3} Da{sup −1}, with an estimated solvent content of 41%. The structure of the enzyme will help guide the design of novel therapeutics against the C. botulinum pathogen.

  6. A Preliminary Analysis of Reactor Performance Test (LOEP) for a Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyeonil; Park, Su-Ki [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    The final phase of commissioning is reactor performance test, which is to prove the integrated performance and safety of the research reactor at full power with fuel loaded such as neutron power calibration, Control Absorber Rod/Second Shutdown Rod drop time, InC function test, Criticality, Rod worth, Core heat removal with natural mechanism, and so forth. The last test will be safety-related one to assure the result of the safety analysis of the research reactor is marginal enough to be sure about the nuclear safety by showing the reactor satisfies the acceptance criteria of the safety functions such as for reactivity control, maintenance of auxiliaries, reactor pool water inventory control, core heat removal, and confinement isolation. After all, the fuel integrity will be ensured by verifying there is no meaningful change in the radiation levels. To confirm the performance of safety equipment, loss of normal electric power (LOEP), possibly categorized as Anticipated Operational Occurrence (AOO), is selected as a key experiment to figure out how safe the research reactor is before turning over the research reactor to the owner. This paper presents a preliminary analysis of the reactor performance test (LOEP) for a research reactor. The results showed how different the transient between conservative estimate and best estimate will look. Preliminary analyses have shown all probable thermal-hydraulic transient behavior of importance as to opening of flap valve, minimum critical heat flux ratio, the change of flow direction, and important values of thermal-hydraulic parameters.

  7. What Do We Mean By Sensitivity Analysis? The Need For A Comprehensive Characterization Of Sensitivity In Earth System Models

    Science.gov (United States)

    Razavi, S.; Gupta, H. V.

    2014-12-01

    Sensitivity analysis (SA) is an important paradigm in the context of Earth System model development and application, and provides a powerful tool that serves several essential functions in modelling practice, including 1) Uncertainty Apportionment - attribution of total uncertainty to different uncertainty sources, 2) Assessment of Similarity - diagnostic testing and evaluation of similarities between the functioning of the model and the real system, 3) Factor and Model Reduction - identification of non-influential factors and/or insensitive components of model structure, and 4) Factor Interdependence - investigation of the nature and strength of interactions between the factors, and the degree to which factors intensify, cancel, or compensate for the effects of each other. A variety of sensitivity analysis approaches have been proposed, each of which formally characterizes a different "intuitive" understanding of what is meant by the "sensitivity" of one or more model responses to its dependent factors (such as model parameters or forcings). These approaches are based on different philosophies and theoretical definitions of sensitivity, and range from simple local derivatives and one-factor-at-a-time procedures to rigorous variance-based (Sobol-type) approaches. In general, each approach focuses on, and identifies, different features and properties of the model response and may therefore lead to different (even conflicting) conclusions about the underlying sensitivity. This presentation revisits the theoretical basis for sensitivity analysis, and critically evaluates existing approaches so as to demonstrate their flaws and shortcomings. With this background, we discuss several important properties of response surfaces that are associated with the understanding and interpretation of sensitivity. Finally, a new approach towards global sensitivity assessment is developed that is consistent with important properties of Earth System model response surfaces.

  8. A comprehensive sensitivity analysis of central-loop MRS data

    Science.gov (United States)

    Behroozmand, Ahmad; Auken, Esben; Dalgaard, Esben; Rejkjaer, Simon

    2014-05-01

    In this study we investigate the sensitivity analysis of separated-loop magnetic resonance sounding (MRS) data and, in light of deploying a separate MRS receiver system from the transmitter system, compare the parameter determination of the central-loop with the conventional coincident-loop MRS data. MRS, also called surface NMR, has emerged as a promising surface-based geophysical technique for groundwater investigations, as it provides a direct estimate of the water content and, through empirical relations, is linked to hydraulic properties of the subsurface such as hydraulic conductivity. The method works based on the physical principle of NMR during which a large volume of protons of the water molecules in the subsurface is excited at the specific Larmor frequency. The measurement consists of a large wire loop deployed on the surface which typically acts as both a transmitter and a receiver, the so-called coincident-loop configuration. An alternating current is passed through the loop deployed and the superposition of signals from all precessing protons within the investigated volume is measured in a receiver loop; a decaying NMR signal called Free Induction Decay (FID). To provide depth information, the FID signal is measured for a series of pulse moments (Q; product of current amplitude and transmitting pulse length) during which different earth volumes are excited. One of the main and inevitable limitations of MRS measurements is a relatively long measurement dead time, i.e. a non-zero time between the end of the energizing pulse and the beginning of the measurement, which makes it difficult, and in some places impossible, to record MRS signal from fine-grained geologic units and limits the application of advanced pulse sequences. Therefore, one of the current research activities is the idea of building separate receiver units, which will diminish the dead time. In light of that, the aims of this study are twofold: 1) Using a forward modeling approach, the

  9. Preliminary design and thermal analysis of device for finish cooling Jaffa biscuits in a.d. 'Jaffa'- Crvenka

    Directory of Open Access Journals (Sweden)

    Salemović Duško R.

    2015-01-01

    Full Text Available In this paper preliminary design of device for finish cooling chocolate topping of biscuits in A.D. 'Jaffa'- Crvenka was done. The proposed preliminary design followed by the required technological process of finish cooling biscuits and required parameters of process which was supposed to get and which represented part of project task. Thermal analysis was made and obtained percentage error between surface contact of the air and chocolate topping, obtained from heat balance and geometrical over proposed preliminary design, wasn't more than 0.67%. This is a preliminary design completely justified because using required length of belt conveyor receive required temperature of chocolate topping at the end of the cooling process.

  10. A Preliminary Analysis of Non-small Cell Lung Cancer Biomarkers in Serum

    Institute of Scientific and Technical Information of China (English)

    XUE-YUAN XIAO; YING TANG; XIU-PING WEI; DA-CHENG HE

    2003-01-01

    Objective To identify potential serum biomarkers that could be used to discriminate lungcancers from normal. Methods Proteomic spectra of twenty-eight serum samples from patientswith non-small cell lung cancer and twelve from normal individuals were generated by SELDI(Surfaced Enhanced Laser Desorption/Ionization) Mass Spectrometry. Anion-exchange columns wereused to fractionate the sera into 6 designated pH groups. Two different types of protein chip arrays,IMAC-Cu and WCX2, were employed. Samples were examined in PBSII Protein Chip Reader(Ciphergen Biosystem Inc) and the discriminatory profiling between cancer and normal samples wasanalyzed with Biomarker Pattern software. Results Five distinct potential lung cancer biomarkerswith higher sensitivity and specificity were found, with four common biomarkers in both IMAC-Cuand WCX2 chip; the remaining biomarker occurred only in WCX2 chip. Two biomarkers wereup-regulated while three biomarkers were down-regulated in the serum samples from patients withnon-small cell lung cancer. The sensitivities provided by the individual biomarkers were 75%-96.43%and specificities were 75%-100%. Conclusions The preliminary results suggest that serum is acapable resource for detecting specific non-small cell lung cancer biomarkers. SELDI massspectrometry is a useful tool for the detection and identification of new potential biomarker ofnon-small cell lung cancer in serum.

  11. Mini-DIAL system measurements coupled with multivariate data analysis to identify TIC and TIM simulants: preliminary absorption database analysis.

    Science.gov (United States)

    Gaudio, P.; Malizia, A.; Gelfusa, M.; Martinelli, E.; Di Natale, C.; Poggi, L. A.; Bellecci, C.

    2017-01-01

    Nowadays Toxic Industrial Components (TICs) and Toxic Industrial Materials (TIMs) are one of the most dangerous and diffuse vehicle of contamination in urban and industrial areas. The academic world together with the industrial and military one are working on innovative solutions to monitor the diffusion in atmosphere of such pollutants. In this phase the most common commercial sensors are based on “point detection” technology but it is clear that such instruments cannot satisfy the needs of the smart cities. The new challenge is developing stand-off systems to continuously monitor the atmosphere. Quantum Electronics and Plasma Physics (QEP) research group has a long experience in laser system development and has built two demonstrators based on DIAL (Differential Absorption of Light) technology could be able to identify chemical agents in atmosphere. In this work the authors will present one of those DIAL system, the miniaturized one, together with the preliminary results of an experimental campaign conducted on TICs and TIMs simulants in cell with aim of use the absorption database for the further atmospheric an analysis using the same DIAL system. The experimental results are analysed with standard multivariate data analysis technique as Principal Component Analysis (PCA) to develop a classification model aimed at identifying organic chemical compound in atmosphere. The preliminary results of absorption coefficients of some chemical compound are shown together pre PCA analysis.

  12. SENSITIVITY ANALYSIS BASED ON LANCZOS ALGORITHM IN STRUCTURAL DYNAMICS

    Institute of Scientific and Technical Information of China (English)

    李书; 王波; 胡继忠

    2003-01-01

    The sensitivity calculating formulas in structural dynamics was developed byutilizing the mathematical theorem and new definitions of sensitivities. So the singularityproblem of sensitivity with repeated eigenvalues is solved completely. To improve thecomputational efficiency, the reduction system is obtained based on Lanczos vectors. Afterincorporating the mathematical theory with the Lanczos algorithm, the approximatesensitivity solution can be obtained. A numerical example is presented to illustrate theperformance of the method.

  13. Performance Model and Sensitivity Analysis for a Solar Thermoelectric Generator

    Science.gov (United States)

    Rehman, Naveed Ur; Siddiqui, Mubashir Ali

    2017-01-01

    In this paper, a regression model for evaluating the performance of solar concentrated thermoelectric generators (SCTEGs) is established and the significance of contributing parameters is discussed in detail. The model is based on several natural, design and operational parameters of the system, including the thermoelectric generator (TEG) module and its intrinsic material properties, the connected electrical load, concentrator attributes, heat transfer coefficients, solar flux, and ambient temperature. The model is developed by fitting a response curve, using the least-squares method, to the results. The sample points for the model were obtained by simulating a thermodynamic model, also developed in this paper, over a range of values of input variables. These samples were generated employing the Latin hypercube sampling (LHS) technique using a realistic distribution of parameters. The coefficient of determination was found to be 99.2%. The proposed model is validated by comparing the predicted results with those in the published literature. In addition, based on the elasticity for parameters in the model, sensitivity analysis was performed and the effects of parameters on the performance of SCTEGs are discussed in detail. This research will contribute to the design and performance evaluation of any SCTEG system for a variety of applications.

  14. Sensitivity Analysis for the CLIC Damping Ring Inductive Adder

    CERN Document Server

    Holma, Janne

    2012-01-01

    The CLIC study is exploring the scheme for an electron-positron collider with high luminosity and a nominal centre-of-mass energy of 3 TeV. The CLIC pre-damping rings and damping rings will produce, through synchrotron radiation, ultra-low emittance beam with high bunch charge, necessary for the luminosity performance of the collider. To limit the beam emittance blow-up due to oscillations, the pulse generators for the damping ring kickers must provide extremely flat, high-voltage pulses. The specifications for the extraction kickers of the CLIC damping rings are particularly demanding: the flattop of the output pulse must be 160 ns duration, 12.5 kV and 250 A, with a combined ripple and droop of not more than ±0.02 %. An inductive adder allows the use of different modulation techniques and is therefore a very promising approach to meeting the specifications. PSpice has been utilised to carry out a sensitivity analysis of the predicted output pulse to the value of both individual and groups of circuit compon...

  15. A Sensitivity Analysis of fMRI Balloon Model

    KAUST Repository

    Zayane, Chadia

    2015-04-22

    Functional magnetic resonance imaging (fMRI) allows the mapping of the brain activation through measurements of the Blood Oxygenation Level Dependent (BOLD) contrast. The characterization of the pathway from the input stimulus to the output BOLD signal requires the selection of an adequate hemodynamic model and the satisfaction of some specific conditions while conducting the experiment and calibrating the model. This paper, focuses on the identifiability of the Balloon hemodynamic model. By identifiability, we mean the ability to estimate accurately the model parameters given the input and the output measurement. Previous studies of the Balloon model have somehow added knowledge either by choosing prior distributions for the parameters, freezing some of them, or looking for the solution as a projection on a natural basis of some vector space. In these studies, the identification was generally assessed using event-related paradigms. This paper justifies the reasons behind the need of adding knowledge, choosing certain paradigms, and completing the few existing identifiability studies through a global sensitivity analysis of the Balloon model in the case of blocked design experiment.

  16. Sensitivity analysis of surface runoff generation in urban flood forecasting.

    Science.gov (United States)

    Simões, N E; Leitão, J P; Maksimović, C; Sá Marques, A; Pina, R

    2010-01-01

    Reliable flood forecasting requires hydraulic models capable to estimate pluvial flooding fast enough in order to enable successful operational responses. Increased computational speed can be achieved by using a 1D/1D model, since 2D models are too computationally demanding. Further changes can be made by simplifying 1D network models, removing and by changing some secondary elements. The Urban Water Research Group (UWRG) of Imperial College London developed a tool that automatically analyses, quantifies and generates 1D overland flow network. The overland flow network features (ponds and flow pathways) generated by this methodology are dependent on the number of sewer network manholes and sewer inlets, as some of the overland flow pathways start at manholes (or sewer inlets) locations. Thus, if a simplified version of the sewer network has less manholes (or sewer inlets) than the original one, the overland flow network will be consequently different. This paper compares different overland flow networks generated with different levels of sewer network skeletonisation. Sensitivity analysis is carried out in one catchment area in Coimbra, Portugal, in order to evaluate overland flow network characteristics.

  17. Plans for a sensitivity analysis of bridge-scour computations

    Science.gov (United States)

    Dunn, David D.; Smith, Peter N.

    1993-01-01

    Plans for an analysis of the sensitivity of Level 2 bridge-scour computations are described. Cross-section data from 15 bridge sites in Texas are modified to reflect four levels of field effort ranging from no field surveys to complete surveys. Data from United States Geological Survey (USGS) topographic maps will be used to supplement incomplete field surveys. The cross sections are used to compute the water-surface profile through each bridge for several T-year recurrence-interval design discharges. The effect of determining the downstream energy grade-line slope from topographic maps is investigated by systematically varying the starting slope of each profile. The water-surface profile analyses are then used to compute potential scour resulting from each of the design discharges. The planned results will be presented in the form of exceedance-probability versus scour-depth plots with the maximum and minimum scour depths at each T-year discharge presented as error bars.

  18. Performance Model and Sensitivity Analysis for a Solar Thermoelectric Generator

    Science.gov (United States)

    Rehman, Naveed Ur; Siddiqui, Mubashir Ali

    2017-03-01

    In this paper, a regression model for evaluating the performance of solar concentrated thermoelectric generators (SCTEGs) is established and the significance of contributing parameters is discussed in detail. The model is based on several natural, design and operational parameters of the system, including the thermoelectric generator (TEG) module and its intrinsic material properties, the connected electrical load, concentrator attributes, heat transfer coefficients, solar flux, and ambient temperature. The model is developed by fitting a response curve, using the least-squares method, to the results. The sample points for the model were obtained by simulating a thermodynamic model, also developed in this paper, over a range of values of input variables. These samples were generated employing the Latin hypercube sampling (LHS) technique using a realistic distribution of parameters. The coefficient of determination was found to be 99.2%. The proposed model is validated by comparing the predicted results with those in the published literature. In addition, based on the elasticity for parameters in the model, sensitivity analysis was performed and the effects of parameters on the performance of SCTEGs are discussed in detail. This research will contribute to the design and performance evaluation of any SCTEG system for a variety of applications.

  19. GPS/INS Integration: A Performance Sensitivity Analysis

    Institute of Scientific and Technical Information of China (English)

    Wang Jin-ling; H. K. Lee; C. Rizos

    2003-01-01

    Inertial Navigation System (INS) and Global Positioning System (GPS) technologies have been widely used in a variety of positioning and navigation applications. Both systems have their unique features and shortcomings. Therefore, the integration of GPS with INS is now critical to overcome each of their drawbacks and to maximize each of their benefits. The integration of GPS with INS can be implemented using a Kalman filter in such modes as loosely, tightly and ultra-tightly coupled. In all these integration modes the INS error states, together with any navigation state (position, velocity, attitude) and other unknown parameters of interest, are estimated using GPS measurements. In a high performance system it is expected that all these unknown states will be precisely estimated. Although it has been noted that both the quality of the GPS measurements and the trajectory and/or manoeuvre characteristics of the problem will have impacts on system performance, a systematic sensitivity analysis is still lacking. This paper will address this issue through real data analyses. The performance analysisresults are very relevant to system design and platform trajectory and/or manoeuvre optimisation.

  20. Sensitivity analysis on parameters and processes affecting vapor intrusion risk.

    Science.gov (United States)

    Picone, Sara; Valstar, Johan; van Gaans, Pauline; Grotenhuis, Tim; Rijnaarts, Huub

    2012-05-01

    A one-dimensional numerical model was developed and used to identify the key processes controlling vapor intrusion risks by means of a sensitivity analysis. The model simulates the fate of a dissolved volatile organic compound present below the ventilated crawl space of a house. In contrast to the vast majority of previous studies, this model accounts for vertical variation of soil water saturation and includes aerobic biodegradation. The attenuation factor (ratio between concentration in the crawl space and source concentration) and the characteristic time to approach maximum concentrations were calculated and compared for a variety of scenarios. These concepts allow an understanding of controlling mechanisms and aid in the identification of critical parameters to be collected for field situations. The relative distance of the source to the nearest gas-filled pores of the unsaturated zone is the most critical parameter because diffusive contaminant transport is significantly slower in water-filled pores than in gas-filled pores. Therefore, attenuation factors decrease and characteristic times increase with increasing relative distance of the contaminant dissolved source to the nearest gas diffusion front. Aerobic biodegradation may decrease the attenuation factor by up to three orders of magnitude. Moreover, the occurrence of water table oscillations is of importance. Dynamic processes leading to a retreating water table increase the attenuation factor by two orders of magnitude because of the enhanced gas phase diffusion.

  1. Context Sensitive Article Ranking with Citation Context Analysis

    CERN Document Server

    Doslu, Metin

    2015-01-01

    It is hard to detect important articles in a specific context. Information retrieval techniques based on full text search can be inaccurate to identify main topics and they are not able to provide an indication about the importance of the article. Generating a citation network is a good way to find most popular articles but this approach is not context aware. The text around a citation mark is generally a good summary of the referred article. So citation context analysis presents an opportunity to use the wisdom of crowd for detecting important articles in a context sensitive way. In this work, we analyze citation contexts to rank articles properly for a given topic. The model proposed uses citation contexts in order to create a directed and weighted citation network based on the target topic. We create a directed and weighted edge between two articles if citation context contains terms related with the target topic. Then we apply common ranking algorithms in order to find important articles in this newly cre...

  2. Sensitivity analysis on parameters and processes affecting vapor intrusion risk

    KAUST Repository

    Picone, Sara

    2012-03-30

    A one-dimensional numerical model was developed and used to identify the key processes controlling vapor intrusion risks by means of a sensitivity analysis. The model simulates the fate of a dissolved volatile organic compound present below the ventilated crawl space of a house. In contrast to the vast majority of previous studies, this model accounts for vertical variation of soil water saturation and includes aerobic biodegradation. The attenuation factor (ratio between concentration in the crawl space and source concentration) and the characteristic time to approach maximum concentrations were calculated and compared for a variety of scenarios. These concepts allow an understanding of controlling mechanisms and aid in the identification of critical parameters to be collected for field situations. The relative distance of the source to the nearest gas-filled pores of the unsaturated zone is the most critical parameter because diffusive contaminant transport is significantly slower in water-filled pores than in gas-filled pores. Therefore, attenuation factors decrease and characteristic times increase with increasing relative distance of the contaminant dissolved source to the nearest gas diffusion front. Aerobic biodegradation may decrease the attenuation factor by up to three orders of magnitude. Moreover, the occurrence of water table oscillations is of importance. Dynamic processes leading to a retreating water table increase the attenuation factor by two orders of magnitude because of the enhanced gas phase diffusion. © 2012 SETAC.

  3. Sensitivity analysis on an AC600 aluminum skin component

    Science.gov (United States)

    Mendiguren, J.; Agirre, J.; Mugarra, E.; Galdos, L.; Saenz de Argandoña, E.

    2016-08-01

    New materials are been introduced on the car body in order to reduce weight and fulfil the international CO2 emission regulations. Among them, the application of aluminum alloys is increasing for skin panels. Even if these alloys are beneficial for the car design, the manufacturing of these components become more complex. In this regard, numerical simulations have become a necessary tool for die designers. There are multiple factors affecting the accuracy of these simulations e.g. hardening, anisotropy, lubrication, elastic behavior. Numerous studies have been conducted in the last years on high strength steels component stamping and on developing new anisotropic models for aluminum cup drawings. However, the impact of the correct modelling on the latest aluminums for the manufacturing of skin panels has been not yet analyzed. In this work, first, the new AC600 aluminum alloy of JLR-Novelis is characterized for anisotropy, kinematic hardening, friction coefficient, elastic behavior. Next, a sensitivity analysis is conducted on the simulation of a U channel (with drawbeads). Then, the numerical an experimental results are correlated in terms of springback and failure. Finally, some conclusions are drawn.

  4. Understanding earth system models: how Global Sensitivity Analysis can help

    Science.gov (United States)

    Pianosi, Francesca; Wagener, Thorsten

    2017-04-01

    Computer models are an essential element of earth system sciences, underpinning our understanding of systems functioning and influencing the planning and management of socio-economic-environmental systems. Even when these models represent a relatively low number of physical processes and variables, earth system models can exhibit a complicated behaviour because of the high level of interactions between their simulated variables. As the level of these interactions increases, we quickly lose the ability to anticipate and interpret the model's behaviour and hence the opportunity to check whether the model gives the right response for the right reasons. Moreover, even if internally consistent, an earth system model will always produce uncertain predictions because it is often forced by uncertain inputs (due to measurement errors, pre-processing uncertainties, scarcity of measurements, etc.). Lack of transparency about the scope of validity, limitations and the main sources of uncertainty of earth system models can be a strong limitation to their effective use for both scientific and decision-making purposes. Global Sensitivity Analysis (GSA) is a set of statistical analysis techniques to investigate the complex behaviour of earth system models in a structured, transparent and comprehensive way. In this presentation, we will use a range of examples across earth system sciences (with a focus on hydrology) to demonstrate how GSA is a fundamental element in advancing the construction and use of earth system models, including: verifying the consistency of the model's behaviour with our conceptual understanding of the system functioning; identifying the main sources of output uncertainty so to focus efforts for uncertainty reduction; finding tipping points in forcing inputs that, if crossed, would bring the system to specific conditions we want to avoid.

  5. Radiation induced chemotherapy sensitization in trimodality therapy of stage 3 non small cell lung cancer. A preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Takita, H. [Millard Fillmore Hospital, Buffalo (United States); Shin, K. H. [CCS Oncology Center, Kenmore, NY, (United States)

    2000-12-01

    The overall cure rate of locally advanced non-small cell lung carcinoma (NSCLC) remains poor. Although there have been encouraging reports of preoperative use of chemotherapy, more recent trend is the trimodal approach of radiation, chemo, and surgical-therapies. With the trimodal therapy, increased tumor response and resectability are reported, however, there are increased treatment related side effects. It was observed that a relatively small dose of radiation given prior to induction chemotherapy greatly enhanced the tumor response to the chemotherapy without increased toxicity. A total of 18 patients (8 3. A and 10 3.B) were initially given 20 Gy of radiation therapy in 10 fractions and then received 2 courses of Taxol combination chemotherapy. The overall response rate was 83% (15/18) and 13 out of 18 patients underwent surgery. There was one postoperative death (not therapy related). It is speculated that the small dose of radiation therapy may have sensitized the tumor to subsequent chemotherapy, and it was suggested a new hypothesis of radiation therapy induced chemotherapy sensitization.

  6. Contact sensitization in venous eczema: Preliminary results of patch testing with Indian standard series and topical medicaments

    Directory of Open Access Journals (Sweden)

    Jindal Rashmi

    2009-01-01

    Full Text Available Background and Aims: Elimination of allergens/topical medications causing contact dermatitis in venous eczema, which poses a significant problem in its chronicity and treatment, provides the basis for better therapeutic outcome. Our objective was to determine the pattern of contact sensitization in venous eczema patients in Himachal Pradesh (India. Methods: Thirty-four patients (M:F, 31:3 and 10 controls (M:F, 6:4 were patch tested with Indian standard series and 10 commonly used topical medicaments. Results: Positive patch test results were seen in 50% (M:F, 16:1 of the patients. Common allergens were Fragrance mix (15%, p-phenylendiamine (15%, nickel (9%, wool alcohol (9%, chinoform (9%, balsum of Peru (5%, cobalt chloride (5%, potassium dichromate (3%, epoxy resin (3%, thiuram mix (3% and formaldehyde (3%. Only sisomycin and miconazole among the topical medications elicited a positive patch test reaction in 3 and 5% patients, respectively. Neomycin contact sensitivity was not seen in any of the patients. One patient who had exacerbation of venous eczema following accidental application of topical diclofenac showed a positive patch test reaction to it. Conclusions: Patch test should be used to identify the topical agents that may be responsible for perpetuation or aggravation of eczema, especially in patients who do not improve despite adequate treatment of other underlying cause(s.

  7. Preliminary Nuclear Analysis for the HANARO Fuel Element with Burnable Absorber

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Chul Gyo; Kim, So Young; In, Won Ho [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Burnable absorber is used for reducing reactivity swing and power peaking in high performance research reactors. Development of the HANARO fuel element with burnable absorber was started in the U-Mo fuel development program at HANARO, but detailed full core analysis was not performed because the current HANARO fuel management system is uncertain to analysis the HANARO core with burnable absorber. A sophisticated reactor physics system is required to analysis the core. The McCARD code was selected and the detailed McCARD core models, in which the basic HANARO core model was developed by one of the McCARD developers, are used in this study. The development of nuclear fuel requires a long time and correct developing direction especially by the nuclear analysis. This paper presents a preliminary nuclear analysis to promote the fuel development. Based on the developed fuel, the further nuclear analysis will improve reactor performance and safety. Basic nuclear analysis for the HANARO and the AHR were performed for getting the proper fuel elements with burnable absorber. Addition of 0.3 - 0.4% Cd to the fuel meat is promising for the current HANARO fuel element. Small addition of burnable absorber may not change any fuel characteristics of the HANARO fuel element, but various basic tests and irradiation tests at the HANARO core are required.

  8. Treatment by gliding arc of epoxy resin: preliminary analysis of surface modifications

    Science.gov (United States)

    Faubert, F.; Wartel, M.; Pellerin, N.; Pellerin, S.; Cochet, V.; Regnier, E.; Hnatiuc, B.

    2016-12-01

    Treatments with atmospheric pressure non-thermal plasma are easy to implement and inexpensive. Among them gliding arc (GlidArc) remains rarely used in surface treatment of polymers. However, it offers economic and flexible way to treat quickly large areas. In addition the choice of carrier gas makes it possible to bring the active species and other radicals allowing different types of grafting and functionalization of the treated surfaces, for example in order to apply for anti-biofouling prevention. This preliminary work includes analysis of the surface of epoxy resins by infrared spectroscopy: the different affected chemical bonds were studied depending on the duration of treatment. The degree of oxidation (the C/O ratio) is obtained by X-ray microanalysis and contact angle analysis have been performed to determinate the wettability properties of the treated surface. A spectroscopic study of the plasma allows to determine the possible active species in the different zones of the discharge.

  9. Los Alamos National Laboratory corregated metal pipe saw facility preliminary safety analysis report. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-09-19

    This Preliminary Safety Analysis Report addresses site assessment, facility design and construction, and design operation of the processing systems in the Corrugated Metal Pipe Saw Facility with respect to normal and abnormal conditions. Potential hazards are identified, credible accidents relative to the operation of the facility and the process systems are analyzed, and the consequences of postulated accidents are presented. The risk associated with normal operations, abnormal operations, and natural phenomena are analyzed. The accident analysis presented shows that the impact of the facility will be acceptable for all foreseeable normal and abnormal conditions of operation. Specifically, under normal conditions the facility will have impacts within the limits posted by applicable DOE guidelines, and in accident conditions the facility will similarly meet or exceed the requirements of all applicable standards. 16 figs., 6 tabs.

  10. Preliminary Uncertainty Analysis for SMART Digital Core Protection and Monitoring System

    Energy Technology Data Exchange (ETDEWEB)

    Koo, Bon Seung; In, Wang Kee; Hwang, Dae Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-05-15

    The Korea Atomic Energy Research Institute (KAERI) developed on-line digital core protection and monitoring systems, called SCOPS and SCOMS as a part of SMART plant protection and monitoring system. SCOPS simplified the protection system by directly connecting the four RSPT signals to each core protection channel and eliminated the control element assembly calculator (CEAC) hardware. SCOMS adopted DPCM3D method in synthesizing core power distribution instead of Fourier expansion method being used in conventional PWRs. The DPCM3D method produces a synthetic 3-D power distribution by coupling a neutronics code and measured in-core detector signals. The overall uncertainty analysis methodology which is used statistically combining uncertainty components of SMART core protection and monitoring system was developed. In this paper, preliminary overall uncertainty factors for SCOPS/SCOMS of SMART initial core were evaluated by applying newly developed uncertainty analysis method

  11. Preliminary cladistic analysis of genera of the cestode order Trypanorhyncha Diesing, 1863.

    Science.gov (United States)

    Beveridge, I; Campbell, R A; Palm, H W

    1999-01-01

    A preliminary cladistic analysis was carried out on the 49 currently recognised genera of the order Trypanorhyncha. Forty-four characters were analysed; a functional outgroup was used for scolex and strobilar characters, while Nybelinia was utilised to polarise characters related to the rhyncheal system. Eight well-resolved clades were evident in the resultant cladogram, which is compared with existing phenetic classifications. An analysis of families resulted in a similar clustering of taxa to that observed in the case of the genera. The results suggest that two key characters used in existing classifications, namely the presence of sensory fossettes on the bothridia and the development of atypical heteroacanth and poeciloacanth armatures from typical heteroacanth armatures, have occurred on several occasions. Some clades provide support for the arrangements used in current classifications. Suggestions are made for future avenues of research which might provide more robust phylogenetic data for the Trypanorhyncha.

  12. Preliminary Evaluation of MapReduce for High-Performance Climate Data Analysis

    Science.gov (United States)

    Duffy, Daniel Q.; Schnase, John L.; Thompson, John H.; Freeman, Shawn M.; Clune, Thomas L.

    2012-01-01

    MapReduce is an approach to high-performance analytics that may be useful to data intensive problems in climate research. It offers an analysis paradigm that uses clusters of computers and combines distributed storage of large data sets with parallel computation. We are particularly interested in the potential of MapReduce to speed up basic operations common to a wide range of analyses. In order to evaluate this potential, we are prototyping a series of canonical MapReduce operations over a test suite of observational and climate simulation datasets. Our initial focus has been on averaging operations over arbitrary spatial and temporal extents within Modern Era Retrospective- Analysis for Research and Applications (MERRA) data. Preliminary results suggest this approach can improve efficiencies within data intensive analytic workflows.

  13. Dimensions of Human-Work Domain Interaction: A Preliminary Analysis for the Design of a Corporate Digital Library.

    Science.gov (United States)

    Xie, Hong

    2003-01-01

    Applies the cognitive system engineering approach to investigate human-work interaction at a corporate setting. Reports preliminary analysis of data collected from diary analysis and interview of 20 subjects. Results identify three dimensions for each of four interactive activities involved in human-work interaction and their relationships.…

  14. When hillslope-derived blocks alter river evolution: A sensitivity analysis

    Science.gov (United States)

    Shobe, C. M.; Tucker, G. E.

    2016-12-01

    Many studies rely on simple models of river channel evolution for predicting channel response to perturbations and landscape evolution outcomes, as well as extracting climatic and tectonic signals from river longitudinal profiles. However, recent work has shown that large, hillslope-derived blocks delivered to rivers in response to rapid incision may noticeably alter the form and evolution of river profiles from the behavior predicted by the most common models. We use a 1-D model of fluvial erosion and block dynamics to investigate the conditions under which this channel-hillslope feedback influences river erosion and landscape evolution. In the model, block delivery by hillslopes occurs in response to channel bed lowering, and blocks inhibit further erosion by covering the bed and reducing effective bed shear stress. Using formal sensitivity analysis techniques including Morris one-at-a-time screening and variance-based decomposition, we seek to explore the full model parameter space and determine which landscape parameters set the influence of blocks on river incision. We use eight response functions to evaluate model behavior, including the mean, standard deviation, and range of the distributions of elevation and slope in the model domain. Preliminary results indicate that baselevel lowering rate, bed erodibility, initial block size, and a parameter governing the connection between river erosion and volume flux of blocks to the channel control whether or not channel evolution will be influenced by hillslope-derived blocks. Surprisingly, block erodibility and the delay timescale separating channel incision from hillslope response have relatively little influence on model outcomes. Results also show that parameter sensitivity is strongly dependent on the chosen response function, highlighting the need for multiple model metrics. Identification of the most important model parameters allows confident identification of landscapes strongly influenced by block delivery

  15. Measurement and Analysis on Neutron Position Sensitive Detector at CARR

    Institute of Scientific and Technical Information of China (English)

    GAO; Jian-bo; HAO; Li-jie; LIU; Xin-zhi; MA; Xiao-bai; LI; Yu-qing

    2013-01-01

    Neutron position sensitive detector is one of the key components for neutron scattering spectrometer.As the eyes of the spectrometer,the detector is mainly used for recording the position and intensity of the neutrons.The 16 linear position sensitive detectors from GE Reuter-Stokes Company have been measured

  16. Preliminary failure modes and effects analysis on Korean HCCR TBS to be tested in ITER

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Mu-Young, E-mail: myahn74@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Cho, Seungyon [National Fusion Research Institute, Daejeon (Korea, Republic of); Jin, Hyung Gon; Lee, Dong Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Yi-Hyun; Lee, Youngmin [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Highlights: • Postulated initiating events are identified through failure modes and effects analysis on the current HCCR TBS design. • A set of postulated initiating events are selected for consideration of deterministic analysis. • Accident evolutions on the selected postualted initiating events are qualitatively described for deterministic analysis. - Abstract: Korean Helium cooled ceramic reflector (HCCR) Test blanket system (TBS), which comprises Test blanket module (TBM) and ancillary systems in various locations of ITER building, is operated at high temperature and pressure with decay heat. Therefore, safety is utmost concern in design process and it is required to demonstrate that the HCCR TBS is designed to comply with the safety requirements and guidelines of ITER. Due to complexity of the system with many interfaces with ITER, a systematic approach is necessary for safety analysis. This paper presents preliminary failure modes and effects analysis (FMEA) study performed for the HCCR TBS. FMEA is a systematic methodology in which failure modes for components in the system and their consequences are studied from the bottom-up. Over eighty failure modes have been investigated on the HCCR TBS. The failure modes that have similar consequences are grouped as postulated initiating events (PIEs) and total seven reference accident scenarios are derived from FMEA study for deterministic accident analysis. Failure modes not covered here due to evolving design of the HCCR TBS and uncertainty in maintenance procedures will be studied further in near future.

  17. Expression, purification, crystallization and preliminary crystallographic analysis of the proliferation-associated protein Ebp1

    Energy Technology Data Exchange (ETDEWEB)

    Kowalinski, Eva; Bange, Gert; Wild, Klemens; Sinning, Irmgard, E-mail: irmi.sinning@bzh.uni-heidelberg.de [Heidelberg University Biochemistry Center, INF 328, D-69120 Heidelberg (Germany)

    2007-09-01

    Preliminary X-ray analysis of the proliferation-associated protein Ebp1 from Homo sapiens is provided. ErbB-3-binding protein 1 (Ebp1) is a member of the family of proliferation-associated 2G4 proteins (PA2G4s) and plays a role in cellular growth and differentiation. Ligand-induced activation of the transmembrane receptor ErbB3 leads to dissociation of Ebp1 from the receptor in a phosphorylation-dependent manner. The non-associated protein is involved in transcriptional and translational regulation in the cell. Here, the overexpression, purification, crystallization and preliminary crystallographic studies of Ebp1 from Homo sapiens are reported. Initially observed crystals were improved by serial seeding to single crystals suitable for data collection. The optimized crystals belong to the tetragonal space group P4{sub 1}2{sub 1}2 or P4{sub 3}2{sub 1}2 and diffracted to a resolution of 1.6 Å.

  18. Preliminary performance assessment for the Waste Isolation Pilot Plant, December 1992. Volume 5, Uncertainty and sensitivity analyses of gas and brine migration for undisturbed performance

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    Before disposing of transuranic radioactive waste in the Waste Isolation Pilot Plant (WIPP), the United States Department of Energy (DOE) must evaluate compliance with applicable long-term regulations of the United States Environmental Protection Agency (EPA). Sandia National Laboratories is conducting iterative performance assessments (PAs) of the WIPP for the DOE to provide interim guidance while preparing for a final compliance evaluation. This volume of the 1992 PA contains results of uncertainty and sensitivity analyses with respect to migration of gas and brine from the undisturbed repository. Additional information about the 1992 PA is provided in other volumes. Volume 1 contains an overview of WIPP PA and results of a preliminary comparison with 40 CFR 191, Subpart B. Volume 2 describes the technical basis for the performance assessment, including descriptions of the linked computational models used in the Monte Carlo analyses. Volume 3 contains the reference data base and values for input parameters used in consequence and probability modeling. Volume 4 contains uncertainty and sensitivity analyses with respect to the EPA`s Environmental Standards for the Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes (40 CFR 191, Subpart B). Finally, guidance derived from the entire 1992 PA is presented in Volume 6. Results of the 1992 uncertainty and sensitivity analyses indicate that, conditional on the modeling assumptions and the assigned parameter-value distributions, the most important parameters for which uncertainty has the potential to affect gas and brine migration from the undisturbed repository are: initial liquid saturation in the waste, anhydrite permeability, biodegradation-reaction stoichiometry, gas-generation rates for both corrosion and biodegradation under inundated conditions, and the permeability of the long-term shaft seal.

  19. Expansive soil-structure interaction and its sensitive analysis

    Institute of Scientific and Technical Information of China (English)

    XIAO Hong-bin; ZHANG Chun-shun; HE Jie; FAN Zhen-hui

    2007-01-01

    Several groups of direct shear tests of Nanning expansive soil samples were carried out by improved direct shear apparatus. The results of the characteristics of the ultimate shear stress and residual shear stress at the interface of expansive soil-structure are presented as follows: linear relation can approximately reflect changes between the both shear stress and the three factors: vertical load, water content and dry density, just different degrees from each other; increasing the vertical load from 25 kPa to 100 kPa (up by 300%) can cause the average increase of ultimate shear stress from 58% (for samples with 1.61 g/cm3) to 80% (for samples with 1.76 g/cm3), and an close average increase of 180% for the residual shear stress; increasing the water content from 14.1% to 20.8% (up by 47.5%) can cause the average decrease of the ultimate shear stress from 40% (for samples with 25 kPa) to 80% (for samples with 100 kPa), and the average decrease from 25% (for samples with 25 kPa) to 30% (for samples with 100 kPa)for the residual shear stress; increasing the dry density from 1.61 g/cm3 to 1.76 g/cm3 (up by 9.3%) can cause the average increase of ultimate shear stress from 92% (for samples with 25 kPa) to 138% (for samples with 100 kPa), and an average increase of 4% for the residual shear stress. Sensitive analysis was further made to explain reasons causing the differences of the both shear stress induced by the three factors.

  20. Sorption of redox-sensitive elements: critical analysis

    Energy Technology Data Exchange (ETDEWEB)

    Strickert, R.G.

    1980-12-01

    The redox-sensitive elements (Tc, U, Np, Pu) discussed in this report are of interest to nuclear waste management due to their long-lived isotopes which have a potential radiotoxic effect on man. In their lower oxidation states these elements have been shown to be highly adsorbed by geologic materials occurring under reducing conditions. Experimental research conducted in recent years, especially through the Waste Isolation Safety Assessment Program (WISAP) and Waste/Rock Interaction Technology (WRIT) program, has provided extensive information on the mechanisms of retardation. In general, ion-exchange probably plays a minor role in the sorption behavior of cations of the above three actinide elements. Formation of anionic complexes of the oxidized states with common ligands (OH/sup -/, CO/sup - -//sub 3/) is expected to reduce adsorption by ion exchange further. Pertechnetate also exhibits little ion-exchange sorption by geologic media. In the reduced (IV) state, all of the elements are highly charged and it appears that they form a very insoluble compound (oxide, hydroxide, etc.) or undergo coprecipitation or are incorporated into minerals. The exact nature of the insoluble compounds and the effect of temperature, pH, pe, other chemical species, and other parameters are currently being investigated. Oxidation states other than Tc (IV,VII), U(IV,VI), Np(IV,V), and Pu(IV,V) are probably not important for the geologic repository environment expected, but should be considered especially when extreme conditions exist (radiation, temperature, etc.). Various experimental techniques such as oxidation-state analysis of tracer-level isotopes, redox potential measurement and control, pH measurement, and solid phase identification have been used to categorize the behavior of the various valence states.

  1. Sensitivity analysis for a type of statically stable sailcrafts

    Institute of Scientific and Technical Information of China (English)

    Zheng-Xue Li; Jun-Feng Li; He-Xi Baoyin

    2012-01-01

    Two types of sensitivities are proposed for statically stable sailcrafts. One type is the sensitivities of solar-radiation-pressure force with respect to position of the center of mass,and the other type is the sensitivities of solar-radiation-pressure force with respect to attitude.The two types of sensitivities represent how the solar-radiationpressure force changes with the position of mass center and the attitude.Sailcrafts with larger sensitivities undergo larger error of the solar-radiation-pressure force,leading to larger orbit error,as demonstrated by simulation.Then as a case study,detailed formulas are derived to calculate the sensitivities for sailcrafts with four triangular sails.According to these formulas,in order to reduce both types of sensitivities,the angle between opposed sails should not be too large,and the center of mass should be as close to the axis of symmetry of the four sails as possible and as far away from the center of pressure of the sailcraft as possible.

  2. SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool.

    Science.gov (United States)

    Zi, Zhike; Zheng, Yanan; Rundell, Ann E; Klipp, Edda

    2008-08-15

    It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for coding and sharing mathematical models of such processes. However, current SBML compatible software tools are limited in their ability to perform global sensitivity analyses of these models. This work introduces a freely downloadable, software package, SBML-SAT, which implements algorithms for simulation, steady state analysis, robustness analysis and local and global sensitivity analysis for SBML models. This software tool extends current capabilities through its execution of global sensitivity analyses using multi-parametric sensitivity analysis, partial rank correlation coefficient, SOBOL's method, and weighted average of local sensitivity analyses in addition to its ability to handle systems with discontinuous events and intuitive graphical user interface. SBML-SAT provides the community of systems biologists a new tool for the analysis of their SBML models of biochemical and cellular processes.

  3. SHORTCUT METHODS FOR SIMPLEX-BASED SENSITIVITY ANALYSIS OF LINEAR PROGRAMMING AND RELATED SOFTWARE ISSUE

    Directory of Open Access Journals (Sweden)

    Muwafaq M. Alkubaisi

    2017-03-01

    Full Text Available This paper has presented an overview of theoretical and methodological issues in simplex based sensitivity analysis (SA. The paper focuses somewhat on developing shortcut methods to perform Linear Programming (L.P. sensitivity analysis manually and in particular to dual prices and its meaning and changes in the parameter of the L.P model. Shortcut methods for conducting sensitivity analysis have been suggested. To perform sensitivity analysis in real life, one needs computer packages (software to achieve the sensitivity analysis report for higher accuracy and to save time. Some of these computer packages are very professional, but, unfortunately, some other packages suffer from logical errors in the programming of sensitivity analysis.

  4. Analysis of Sea Ice Cover Sensitivity in Global Climate Model

    Directory of Open Access Journals (Sweden)

    V. P. Parhomenko

    2014-01-01

    Full Text Available The paper presents joint calculations using a 3D atmospheric general circulation model, an ocean model, and a sea ice evolution model. The purpose of the work is to analyze a seasonal and annual evolution of sea ice, long-term variability of a model ice cover, and its sensitivity to some parameters of model as well to define atmosphere-ice-ocean interaction.Results of 100 years simulations of Arctic basin sea ice evolution are analyzed. There are significant (about 0.5 m inter-annual fluctuations of an ice cover.The ice - atmosphere sensible heat flux reduced by 10% leads to the growth of average sea ice thickness within the limits of 0.05 m – 0.1 m. However in separate spatial points the thickness decreases up to 0.5 m. An analysis of the seasonably changing average ice thickness with decreasing, as compared to the basic variant by 0.05 of clear sea ice albedo and that of snow shows the ice thickness reduction in a range from 0.2 m up to 0.6 m, and the change maximum falls for the summer season of intensive melting. The spatial distribution of ice thickness changes shows, that on the large part of the Arctic Ocean there was a reduction of ice thickness down to 1 m. However, there is also an area of some increase of the ice layer basically in a range up to 0.2 m (Beaufort Sea. The 0.05 decrease of sea ice snow albedo leads to reduction of average ice thickness approximately by 0.2 m, and this value slightly depends on a season. In the following experiment the ocean – ice thermal interaction influence on the ice cover is estimated. It is carried out by increase of a heat flux from ocean to the bottom surface of sea ice by 2 W/sq. m in comparison with base variant. The analysis demonstrates, that the average ice thickness reduces in a range from 0.2 m to 0.35 m. There are small seasonal changes of this value.The numerical experiments results have shown, that an ice cover and its seasonal evolution rather strongly depend on varied parameters

  5. Parametric sensitivity analysis of a test cell thermal model using spectral analysis

    CERN Document Server

    Mara, Thierry Alex; Garde, François

    2012-01-01

    The paper deals with an empirical validation of a building thermal model. We put the emphasis on sensitivity analysis and on research of inputs/residual correlation to improve our model. In this article, we apply a sensitivity analysis technique in the frequency domain to point out the more important parameters of the model. Then, we compare measured and predicted data of indoor dry-air temperature. When the model is not accurate enough, recourse to time-frequency analysis is of great help to identify the inputs responsible for the major part of error. In our approach, two samples of experimental data are required. The first one is used to calibrate our model the second one to really validate the optimized model.

  6. Air Gun Launch Simulation Modeling and Finite Element Model Sensitivity Analysis

    Science.gov (United States)

    2006-01-01

    Air Gun Launch Simulation Modeling and Finite Element Model Sensitivity Analysis by Mostafiz R. Chowdhury and Ala Tabiei ARL-TR-3703...Adelphi, MD 20783-1145 ARL-TR-3703 January 2006 Air Gun Launch Simulation Modeling and Finite Element Model Sensitivity Analysis...GRANT NUMBER 4. TITLE AND SUBTITLE Air Gun Launch Simulation Modeling and Finite Element Model Sensitivity Analysis 5c. PROGRAM

  7. Computational aspects of sensitivity calculations in linear transient structural analysis

    Science.gov (United States)

    Greene, W. H.; Haftka, R. T.

    1991-01-01

    The calculation of sensitivities of displacements, velocities, accelerations, and stresses in linear, structural, and transient response problems is studied. Several existing sensitivity calculation methods and two new methods are compared for three example problems. Approximation vectors such as vibration mode shapes are used to reduce the dimensionality of the finite model. To be computationally practical in large-order problems, the overall finite difference methods must use the approximation vectors from the original design in the analyses of the perturbed models. This was found to result in poor convergence of stress sensitivities in several cases. Two semianalytical techniques are developed to overcome this poor convergence. Both new methods result in very good convergence of the stress sensitivities; the computational cost is much less than would result if the vibration modes were recalculated and then used in an overall finite difference method.

  8. Decoupled direct method for sensitivity analysis in combustion kinetics

    Science.gov (United States)

    Radhakrishnan, Krishnan

    1987-01-01

    An efficient, decoupled direct method for calculating the first order sensitivity coefficients of homogeneous, batch combustion kinetic rate equations is presented. In this method the ordinary differential equations for the sensitivity coefficients are solved separately from , but sequentially with, those describing the combustion chemistry. The ordinary differential equations for the thermochemical variables are solved using an efficient, implicit method (LSODE) that automatically selects the steplength and order for each solution step. The solution procedure for the sensitivity coefficients maintains accuracy and stability by using exactly the same steplengths and numerical approximations. The method computes sensitivity coefficients with respect to any combination of the initial values of the thermochemical variables and the three rate constant parameters for the chemical reactions. The method is illustrated by application to several simple problems and, where possible, comparisons are made with exact solutions and those obtained by other techniques.

  9. Application of simplified model to sensitivity analysis of solidification process

    Directory of Open Access Journals (Sweden)

    R. Szopa

    2007-12-01

    Full Text Available The sensitivity models of thermal processes proceeding in the system casting-mould-environment give the essential information concerning the influence of physical and technological parameters on a course of solidification. Knowledge of time-dependent sensitivity field is also very useful in a case of inverse problems numerical solution. The sensitivity models can be constructed using the direct approach, this means by differentiation of basic energy equations and boundary-initial conditions with respect to parameter considered. Unfortunately, the analytical form of equations and conditions obtained can be very complex both from the mathematical and numerical points of view. Then the other approach consisting in the application of differential quotient can be applied. In the paper the exact and approximate approaches to the modelling of sensitivity fields are discussed, the examples of computations are also shown.

  10. Sensitivity analysis of the age-structured malaria transmission model

    Science.gov (United States)

    Addawe, Joel M.; Lope, Jose Ernie C.

    2012-09-01

    We propose an age-structured malaria transmission model and perform sensitivity analyses to determine the relative importance of model parameters to disease transmission. We subdivide the human population into two: preschool humans (below 5 years) and the rest of the human population (above 5 years). We then consider two sets of baseline parameters, one for areas of high transmission and the other for areas of low transmission. We compute the sensitivity indices of the reproductive number and the endemic equilibrium point with respect to the two sets of baseline parameters. Our simulations reveal that in areas of either high or low transmission, the reproductive number is most sensitive to the number of bites by a female mosquito on the rest of the human population. For areas of low transmission, we find that the equilibrium proportion of infectious pre-school humans is most sensitive to the number of bites by a female mosquito. For the rest of the human population it is most sensitive to the rate of acquiring temporary immunity. In areas of high transmission, the equilibrium proportion of infectious pre-school humans and the rest of the human population are both most sensitive to the birth rate of humans. This suggests that strategies that target the mosquito biting rate on pre-school humans and those that shortens the time in acquiring immunity can be successful in preventing the spread of malaria.

  11. Sensitivity analysis of a pharmaceutical tablet production process from the control engineering perspective.

    Science.gov (United States)

    Rehrl, Jakob; Gruber, Arlin; Khinast, Johannes G; Horn, Martin

    2017-01-30

    This paper presents a sensitivity analysis of a pharmaceutical direct compaction process. Sensitivity analysis is an important tool for gaining valuable process insights and designing a process control concept. Examining its results in a systematic manner makes it possible to assign actuating signals to controlled variables. This paper presents mathematical models for individual unit operations, on which the sensitivity analysis is based. Two sensitivity analysis methods are outlined: (i) based on the so-called Sobol indices and (ii) based on the steady-state gains and the frequency response of the proposed plant model.

  12. A preliminary analysis of climate change effect on long-term risk-based design of flood defense

    Science.gov (United States)

    Wang, L.; Van Gelder, P. H. A. J. M.; Vrijling, J. K.

    2012-04-01

    The lifetime of a flood defense usually lasts for decades or centuries. The future flood probabilistic distribution is not stationary due to climate change. Therefore in the long-term design of flood defense systems, the effect of climate change should be taken into account. The design height of Bengbu dike segment (about 10 km) along Huai River in China is studied as an example to explore the potential effects of climate change on long-term risk-based design. The economic-optimal design height of the dike is determined based on cost-benefit analysis. In this analysis the incremental investments in more safety are balanced with the reduction of the risk. Since climate change will result in the change of flood probability and hence the change of flooding risk, the optimal height might be shifted. To describe the possible future climate, the ensemble prediction of Global Climate Models (GCMs) is used in the study. River runoff series, which is required in deriving annual probability of peak runoff, is obtained by forcing a hydrological model with each GCM climate prediction. Then the probability of high water level in the river is derived based on the relationship between water level and peak runoff. The probability of flooding is assumed to equal to the exceedance probability of the high water level in the river. The possible future flood risk is calculated based on the flooding probability estimates, and is corresponding to each member of the GCMs ensemble. The result will provide information about the significance of potential effects of climate change on the long-term design of flood defense. With comparison to the baseline period, the shift of risk curve in future will be shown on the cost-benefit diagram as well as the change of economic optimal design dike height. As it is a preliminary analysis in this study a sensitivity analysis will be carried out. The sensitivity of use of GCMs ensemble, the damage value and the investment cost will be investigated.

  13. Preliminary Analysis on the Relative Solution Space Sizes for MTSP with Genetic Algorithm

    Science.gov (United States)

    Hao, Junling

    It is well known that the chromosome design is pivotal to solve the multiple traveling salesman problems with genetic algorithm. A well-designed chromosome coding can eliminate or reduce the redundant solutions. One chromosome and two chromosome design methods and a recently proposed two-part chromosome design are firstly introduced in this paper. Then the preliminary quantitative comparison analysis of the solution spaces of three different chromosome design methods is presented when the number of cities is linear with the travelers. The concept of relative solution space is proposed in order to compare the relative size of the solution spaces. The solution space of two-part chromosome design is much smaller than those of the traditional chromosome design. The result given in this paper provides a good guideline for the possible algorithmic design and engineering applications.

  14. Crystallization and preliminary X-ray analysis of alginate importer from Sphingomonas sp. A1.

    Science.gov (United States)

    Maruyama, Yukie; Itoh, Takafumi; Nishitani, Yu; Mikami, Bunzo; Hashimoto, Wataru; Murata, Kousaku

    2012-03-01

    Sphingomonas sp. A1 directly incorporates alginate polysaccharides through a 'superchannel' comprising a pit on the cell surface, alginate-binding proteins in the periplasm and an ABC transporter (alginate importer) in the inner membrane. Alginate importer, consisting of four subunits, AlgM1, AlgM2 and two molecules of AlgS, was crystallized in the presence of the binding protein AlgQ2. Preliminary X-ray analysis showed that the crystal diffracted to 3.3 Å resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 72.5, b = 136.8, c = 273.3 Å, suggesting the presence of one complex in the asymmetric unit.

  15. ANSI/ASHRAE/IES Standard 90.1-2013 Preliminary Determination: Qualitative Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Halverson, Mark A.; Hart, Reid; Athalye, Rahul A.; Rosenberg, Michael I.; Richman, Eric E.; Winiarski, David W.

    2014-03-01

    Section 304(b) of the Energy Conservation and Production Act (ECPA), as amended, requires the Secretary of Energy to make a determination each time a revised version of ASHRAE Standard 90.1 is published with respect to whether the revised standard would improve energy efficiency in commercial buildings. When the U.S. Department of Energy (DOE) issues an affirmative determination on Standard 90.1, states are statutorily required to certify within two years that they have reviewed and updated the commercial provisions of their building energy code, with respect to energy efficiency, to meet or exceed the revised standard. This report provides a preliminary qualitative analysis of all addenda to ANSI/ASHRAE/IES Standard 90.1-2010 (referred to as Standard 90.1-2010 or 2010 edition) that were included in ANSI/ASHRAE/IES Standard 90.1-2013 (referred to as Standard 90.1-2013 or 2013 edition).

  16. Crystallization and preliminary X-ray analysis of Rv1674c from Mycobacterium tuberculosis

    Science.gov (United States)

    Li, Jincheng; Wang, Xudong; Gong, Weimin; Niu, Chunyan; Zhang, Min

    2015-01-01

    Adaptations to hypoxia play an important role in Mycobacterium tuberculosis pathogenesis. Rv0324, which contains an HTH DNA-binding domain and a rhodanese domain, is one of the key transcription regulators in response to hypoxia. M. tuberculosis Rv1674c is a homologue of Rv0324. To understand the interdomain interaction and regulation of the HTH domain and the rhodanese domain, recombinant Rv1674c protein was purified and crystallized by the vapour-diffusion method. The crystals diffracted to 2.25 Å resolution. Preliminary diffraction analysis suggests that the crystals belonged to space group P3121 or P3221, with unit-cell parameters a = b = 67.8, c = 174.5 Å, α = β = 90, γ = 120°. The Matthews coefficient was calculated to be 2.44 Å3 Da−1, assuming that the crystallographic asymmetric unit contains two protein molecules. PMID:25760714

  17. Preliminary phytochemical analysis, antibacterial, antifungal and anticandidal activities of successive extracts of Crossandra infundibuliformis

    Institute of Scientific and Technical Information of China (English)

    MadhumithaG; SaralAM

    2011-01-01

    Objective:To investigate the phytochemical, antibacterial, antifungal and anticandidal activity of successive extracts of Crossandra infundibuliformis (Acanthaceae) leaves. Methods:Preliminary screening on the presence of alkaloids, saponins, phytosterols, phenolic compounds, flavanoids, tannins, carbohydrates, terpenoids, oils and fats were carried out by phytochemical analysis. The antibacterial, antifungal and anticandidal activities were done by agar well diffusion technique. Results:The successive extracts have an array of chemical constituents and the MIC values of antibacterial activity ranges from 0.007 8 to 0.015 0μg/mL. In case of antifungal and anticandidal activities the MIC values were between 0.125 and 0.250μg/mL. Conclusions:These findings demonstrate that the leaf extracts of C. infundibuliformis presents excellent antimicrobial activities and thus have great potential as a source for natural health care products.

  18. Preliminary C3 Loading Analysis for Future High-Altitude Unmanned Aircraft in the NAS

    Science.gov (United States)

    Ho, Yan-Shek; Gheorghisor, Izabela; Box, Frank

    2006-01-01

    This document provides a preliminary assessment and summary of the command, control, and communications (C(sup 3)) loading requirements of a generic future high-altitude, long-endurance unmanned aircraft (UA) operating at in the National Airspace System. Two principal types of C(sup 3) traffic are considered in our analysis: communications links providing air traffic services (ATS) to the UA and its human pilot, and the command and control data links enabling the pilot to operate the UA remotely. we have quantified the loading requirements of both types of traffic for two different assumed levels of UA autonomy. Our results indicate that the potential use of UA-borne relays for the ATS links, and the degree of autonomy exercised by the UA during the departure and arrival phases of its flight, will be among the key drivers of C(sup 3) loading and bandwidth requirements.

  19. Visual Assessment on Coastal Cruise Tourism: A Preliminary Planning Using Importance Performance Analysis

    Science.gov (United States)

    Trisutomo, S.

    2017-07-01

    Importance-Performance Analysis (IPA) has been widely applied in many cases. In this research, IPA was applied to measure perceive on coastal tourism objects and its possibility to be developed as coastal cruise tourism in Makassar. Three objects, i.e. Akkarena recreational site, Losari public space at waterfront, and Paotere traditional Phinisi ships port, were selected and assessed visually from water area by a group of purposive resource persons. The importance and performance of 10 attributes of each site were scored using Likert scale from 1 to 5. Data were processed by SPSS-21 than resulted Cartesian graph which the scores were divided in four quadrants: Quadrant I concentric here, Quadrant II keep up the good work, Quadrant III low priority, and Quadrant IV possible overkill. The attributes in each quadrant could be considered as the platform for preliminary planning of coastal cruise tour in Makassar

  20. Preliminary control system design and analysis for the Space Station Furnace Facility thermal control system

    Science.gov (United States)

    Jackson, M. E.

    1995-01-01

    This report presents the Space Station Furnace Facility (SSFF) thermal control system (TCS) preliminary control system design and analysis. The SSFF provides the necessary core systems to operate various materials processing furnaces. The TCS is defined as one of the core systems, and its function is to collect excess heat from furnaces and to provide precise cold temperature control of components and of certain furnace zones. Physical interconnection of parallel thermal control subsystems through a common pump implies the description of the TCS by coupled nonlinear differential equations in pressure and flow. This report formulates the system equations and develops the controllers that cause the interconnected subsystems to satisfy flow rate tracking requirements. Extensive digital simulation results are presented to show the flow rate tracking performance.

  1. Acanthamoeba polyphaga mimivirus NDK: preliminary crystallographic analysis of the first viral nucleoside diphosphate kinase.

    Science.gov (United States)

    Jeudy, Sandra; Coutard, Bruno; Lebrun, Régine; Abergel, Chantal

    2005-06-01

    The complete sequence of the largest known double-stranded DNA virus, Acanthamoeba polyphaga mimivirus, has recently been determined [Raoult et al. (2004), Science, 306, 1344-1350] and revealed numerous genes not expected to be found in a virus. A comprehensive structural and functional study of these gene products was initiated [Abergel et al. (2005), Acta Cryst. F61, 212-215] both to better understand their role in the virus physiology and to obtain some clues to the origin of DNA viruses. Here, the preliminary crystallographic analysis of the viral nucleoside diphosphate kinase protein is reported. The crystal belongs to the cubic space group P2(1)3, with unit-cell parameter 99.425 A. The self-rotation function confirms that there are two monomers per asymmetric unit related by a twofold non-crystallographic axis and that the unit cell thus contains four biological entities.

  2. Preliminary analysis of habitat utilization by woodland caribou in northwestern Ontario using satellite telemetry

    Directory of Open Access Journals (Sweden)

    T.L. Hillis

    1998-03-01

    Full Text Available Locational data collected over a one year period from 10 female woodland caribou, Rangifer tarandus caribou, collared with Argos satellite collars in northwestern Ontario, Canada were superimposed on supervised Landsat images using Geographical Information System (GIS technology. Landscape parameters, land cover classifications, and drainage were utilized to create the basemap. Using ARCVIEW software, all digital fixes from collared caribou with information of date, time, and activity status were overlain on the basemap to facilitate a preliminary analysis of habitat use in this species. Results supported the conclusions (1 that woodland caribou in northwestern Ontario select habitats containing high to moderate conifer cover and avoided disturbed areas and shrub-rich habitats, (2 that seasonal changes in habitat utilization occurs in females of this species, and (3 that satellite telemetry technology can be employed in the boreal forest ecosystem to assess habitat utilization by large ungulate species.

  3. Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I

    Energy Technology Data Exchange (ETDEWEB)

    Ariza, Antonio; Vickers, Tim J.; Greig, Neil; Fairlamb, Alan H.; Bond, Charles S., E-mail: c.s.bond@dundee.ac.uk [Division of Biological Chemistry and Molecular Microbiology, Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Dundee DD1 5EH,Scotland (United Kingdom)

    2005-08-01

    The detoxification enzyme glyoxalase I from L. major has been crystallized. Preliminary molecular-replacement calculations indicate the presence of three glyoxalase I dimers in the asymmetric unit. Glyoxalase I (GLO1) is a putative drug target for trypanosomatids, which are pathogenic protozoa that include the causative agents of leishmaniasis. Significant sequence and functional differences between Leishmania major and human GLO1 suggest that it may make a suitable template for rational inhibitor design. L. major GLO1 was crystallized in two forms: the first is extremely disordered and does not diffract, while the second, an orthorhombic form, produces diffraction to 2.0 Å. Molecular-replacement calculations indicate that there are three GLO1 dimers in the asymmetric unit, which take up a helical arrangement with their molecular dyads arranged approximately perpendicular to the c axis. Further analysis of these data are under way.

  4. Cognitive Work Analysis: Preliminary Data for a Model of Problem Solving Strategies

    Science.gov (United States)

    Rothmayer, Mark; Blue, Jennifer

    2007-10-01

    Investigations into problem solving strategies are part of the field of physics education research where investigators seek to improve physics instruction by conducting basic research of problem solving abilities among students, differences in knowledge representations between experts and novices, and how to transfer knowledge structures more effectively onto novices. We developed a new conceptual research tool in our laboratory, where we could potentially map the step by step flow of problem solving strategies among experts and novices. This model is derived from the theory of Cognitive Work Analysis, which is grounded in ecological psychology, and as far as we know it has never been applied to a knowledge domain like physics. We collected survey data from 140 undergraduates enrolled in an algebra based introductory physics course at Miami University as part of a larger study aimed to test the validity of the model. Preliminary data will be presented and discussed.

  5. Preliminary risk analysis applied to the transmission of Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Bertrand, E; Schlatter, J

    2011-01-01

    Transmissible spongiform encephalopathy (TSE) is a degenerative disease of the central nervous system. As yet, there is no human screening test and no effective treatment. This disease is invariably fatal. General preventive measures are therefore essential. The objective of this study is to analyze and address on a prioritized basis the risks relating to the transmission of Creutzfeldt-Jakob disease during surgical operations by means of a preliminary risk analysis (PRA). The PRA produces 63 scenarios with maximum risk relating to operational and legal dangers. The study recommends a number of courses of action, such as training and internal controls, in order to reduce the risks identified. A procedure has been drawn up and assessed for each action. This PRA makes it possible to target and significantly reduce the potential dangers for transmission of Creutzfeldt-Jakob disease through the use of medical instruments.

  6. Crystallization and preliminary X-ray diffraction analysis of West Nile virus

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann, Barbel; Plevka, Pavel; Kuhn, Richard J.; Rossmann, Michael G. (Purdue)

    2010-05-25

    West Nile virus, a human pathogen, is closely related to other medically important flaviviruses of global impact such as dengue virus. The infectious virus was purified from cell culture using polyethylene glycol (PEG) precipitation and density-gradient centrifugation. Thin amorphously shaped crystals of the lipid-enveloped virus were grown in quartz capillaries equilibrated by vapor diffusion. Crystal diffraction extended at best to a resolution of about 25 {angstrom} using synchrotron radiation. A preliminary analysis of the diffraction images indicated that the crystals had unit-cell parameters a {approx_equal} b {approx_equal} 480 {angstrom}, {gamma} = 120{sup o}, suggesting a tight hexagonal packing of one virus particle per unit cell.

  7. Preliminary performance analysis of the advanced pulse compression noise radar waveform

    Science.gov (United States)

    Govoni, Mark A.; Moyer, Lee R.

    2012-06-01

    Noise radar systems encounter target fluctuation behavior similar to that of conventional systems. For noise radar systems, however, the fluctuations are not only dictated by target composition and geometry, but also by the non-uniform power envelope of their random transmit signals. This third dependency is of interest and serves as the basis for the preliminary analysis conducted in this manuscript. General conclusions are drawn on the implications of having a random power envelope and the impacts it could have on both the transmit and receive processes. Using an advanced pulse compression noise (APCN) radar waveform as the constituent signal, a computer simulation aids in quantifying potential losses and the impacts they might have on the detection performance of a real radar system.

  8. Preliminary Analysis of Aircraft Loss of Control Accidents: Worst Case Precursor Combinations and Temporal Sequencing

    Science.gov (United States)

    Belcastro, Christine M.; Groff, Loren; Newman, Richard L.; Foster, John V.; Crider, Dennis H.; Klyde, David H.; Huston, A. McCall

    2014-01-01

    Aircraft loss of control (LOC) is a leading cause of fatal accidents across all transport airplane and operational classes, and can result from a wide spectrum of hazards, often occurring in combination. Technologies developed for LOC prevention and recovery must therefore be effective under a wide variety of conditions and uncertainties, including multiple hazards, and their validation must provide a means of assessing system effectiveness and coverage of these hazards. This requires the definition of a comprehensive set of LOC test scenarios based on accident and incident data as well as future risks. This paper defines a comprehensive set of accidents and incidents over a recent 15 year period, and presents preliminary analysis results to identify worst-case combinations of causal and contributing factors (i.e., accident precursors) and how they sequence in time. Such analyses can provide insight in developing effective solutions for LOC, and form the basis for developing test scenarios that can be used in evaluating them. Preliminary findings based on the results of this paper indicate that system failures or malfunctions, crew actions or inactions, vehicle impairment conditions, and vehicle upsets contributed the most to accidents and fatalities, followed by inclement weather or atmospheric disturbances and poor visibility. Follow-on research will include finalizing the analysis through a team consensus process, defining future risks, and developing a comprehensive set of test scenarios with correlation to the accidents, incidents, and future risks. Since enhanced engineering simulations are required for batch and piloted evaluations under realistic LOC precursor conditions, these test scenarios can also serve as a high-level requirement for defining the engineering simulation enhancements needed for generating them.

  9. Active Fault Diagnosis for Hybrid Systems Based on Sensitivity Analysis and EKF

    DEFF Research Database (Denmark)

    Gholami, Mehdi; Schiøler, Henrik; Bak, Thomas

    2011-01-01

    An active fault diagnosis approach for different kinds of faults is proposed. The input of the approach is designed off-line based on sensitivity analysis such that the maximum sensitivity for each individual system parameter is obtained. Using maximum sensitivity, results in a better precision i...

  10. The High Time Resolution Universe Survey - III. Single-pulse searches and preliminary analysis

    CERN Document Server

    Burke-Spolaor, S; Johnston, S; Bates, S D; Bhat, N D R; Burgay, M; D'Amico, N; Jameson, A; Keith, M J; Kramer, M; Levin, L; Milia, S; Possenti, A; Stappers, B; van Straten, W

    2011-01-01

    We present the search methods and initial results for transient radio signals in the High Time Resolution Universe (HTRU) Survey. The HTRU survey's single-pulse search, the software designed to perform the search, and a determination of the HTRU survey's sensitivity to single pulses are described. Initial processing of a small fraction of the survey has produced 11 discoveries, all of which are sparsely-emitting neutron stars, as well as provided confirmation of two previously unconfirmed neutron stars. Most of the newly discovered objects lie in regions surveyed previously, indicating both the improved sensitivity of the HTRU survey observing system and the dynamic nature of the radio sky. The cycles of active and null states in nulling pulsars, rotating radio transients (RRATs), and long-term intermittent pulsars are explored in the context of determining the relationship between these populations, and of the sensitivity of a search to the various radio-intermittent neutron star populations. This analysis s...

  11. Ethical Sensitivity in Nursing Ethical Leadership: A Content Analysis of Iranian Nurses Experiences.

    Science.gov (United States)

    Esmaelzadeh, Fatemeh; Abbaszadeh, Abbas; Borhani, Fariba; Peyrovi, Hamid

    2017-01-01

    Considering that many nursing actions affect other people's health and life, sensitivity to ethics in nursing practice is highly important to ethical leaders as a role model. The study aims to explore ethical sensitivity in ethical nursing leaders in Iran. This was a qualitative study based on the conventional content analysis in 2015. Data were collected using deep and semi-structured interviews with 20 Iranian nurses. The participants were chosen using purposive sampling. Data were analyzed using conventional content analysis. In order to increase the accuracy and integrity of the data, Lincoln and Guba's criteria were considered. Fourteen sub-categories and five main categories emerged. Main categories consisted of sensitivity to care, sensitivity to errors, sensitivity to communication, sensitivity in decision making and sensitivity to ethical practice. Ethical sensitivity appears to be a valuable attribute for ethical nurse leaders, having an important effect on various aspects of professional practice and help the development of ethics in nursing practice.

  12. How to assess the Efficiency and "Uncertainty" of Global Sensitivity Analysis?

    Science.gov (United States)

    Haghnegahdar, Amin; Razavi, Saman

    2016-04-01

    Sensitivity analysis (SA) is an important paradigm for understanding model behavior, characterizing uncertainty, improving model calibration, etc. Conventional "global" SA (GSA) approaches are rooted in different philosophies, resulting in different and sometime conflicting and/or counter-intuitive assessment of sensitivity. Moreover, most global sensitivity techniques are highly computationally demanding to be able to generate robust and stable sensitivity metrics over the entire model response surface. Accordingly, a novel sensitivity analysis method called Variogram Analysis of Response Surfaces (VARS) is introduced to overcome the aforementioned issues. VARS uses the Variogram concept to efficiently provide a comprehensive assessment of global sensitivity across a range of scales within the parameter space. Based on the VARS principles, in this study we present innovative ideas to assess (1) the efficiency of GSA algorithms and (2) the level of confidence we can assign to a sensitivity assessment. We use multiple hydrological models with different levels of complexity to explain the new ideas.

  13. Sensitivity analysis of random two-body interactions

    CERN Document Server

    Johnson, Calvin W

    2010-01-01

    The input to the configuration-interaction shell model includes many dozens or hundreds of independent two-body matrix elements. Previous studies have shown that when fitting to experimental low-lying spectra, the greatest sensitivity is to only a few linear combinations of matrix elements. Here we consider interactions drawn from the two-body random ensemble, or TBRE, and find that the low-lying spectra are also most sensitive to only a few linear combinations of two-body matrix elements, in a fashion nearly indistinguishable from an interaction empirically fit to data. We find in particular the spectra for both the random and empirical interactions are sensitive to similar matrix elements, which we analyze using monopole and contact interactions.

  14. SENSITIVITY ANALYSIS FOR ROLLING PROCESS BASED ON SUPPORT VECTOR MACHINE

    Institute of Scientific and Technical Information of China (English)

    Huang Yanwei; Wu Tihua; Zhao Jingyi; Wang Yiqun

    2005-01-01

    A method for the calculation of the sensitivity factors of the rolling process has been obtained by differentiating the roll force model based on support vector machine. It can eliminate the algebraic loop of the analytical model of the rolling process. The simulations in the first stand of five stand cold tandem rolling mill indicate that the calculation for sensitivities by this proposed method can obtain a good accuracy, and an appropriate adjustment on the control variables determined directly by the sensitivity has an excellent compensation accuracy. Moreover, the roll gap has larger effect on the exit thickness than both front tension and back tension, and it is more efficient to select the roll gap as the controlvariable of the thickness control system in the first stand.

  15. Analysis of Natural Sensitizers to Enhance the Efficiency in Dye Sensitized Solar Cell

    Directory of Open Access Journals (Sweden)

    S.Rajkumar

    2016-05-01

    Full Text Available Three vegetable dyes are used for the study: anthocyanin dye from pomegranate arils extract, betalain dye from beet root extract and chlorophyll dye from tridax procumbens leaf. The anthocyanin and betalain, anthocyanin and chlorophyll, betalain and chlorophyll dyes are blended in cocktail in equal proportions, by volume. This study determines the effect of different extraction concentrations and different vegetable dyes on energy gap using dye sensitized solar cells. The experimental results show that the cocktail dye blended using extracts of pomegranate arils, beet root and tridax procumbens leaf, in the volumetric proportion 1:1, using an extraction at room temperature the greatest energy gap (eg of up to 1.87eV.

  16. Sensitivity analysis on the performances of a closed-loop Ground Source Heat Pump

    Science.gov (United States)

    Casasso, Alessandro; Sethi, Rajandrea

    2014-05-01

    Ground Source Heat Pumps (GSHP) permit to achieve a significant reduction of greenhouse gas emissions, and the margins for economic saving of this technology are strongly correlated to the long-term sustainability of the exploitation of the heat stored in the soil. The operation of a GSHP over its lifetime should be therefore modelled considering realistic conditions, and a thorough characterization of the physical properties of the soil is essential to avoid large errors of prediction. In this work, a BHE modelling procedure with the finite-element code FEFLOW is presented. Starting from the governing equations of the heat transport in the soil around a GSHP and inside the BHE, the most important parameters are individuated and the adopted program settings are explained. A sensitivity analysis is then carried on both the design parameters of the heat exchanger, in order to understand the margins of improvement of a careful design and installation, and the physical properties of the soil, with the aim of quantifying the uncertainty induced by their variability. The relative importance of each parameter is therefore assessed by comparing the statistical distributions of the fluid temperatures and estimating the energy consumption of the heat pump, and practical conclusions are from these results about the site characterization, the design and the installation of a BHE. References Casasso A., Sethi R., 2014 Efficiency of closed loop geothermal heat pumps: A sensitivity analysis, Renewable Energy 62 (2014), pp. 737-746 Chiasson A.C., Rees S.J., Spitler J.D., 2000, A preliminary assessment of the effects of groundwater flow on closed-loop ground-source heat pump systems, ASHRAE Transactions 106 (2000), pp. 380-393 Delaleux F., Py X., Olives R., Dominguez A., 2012, Enhancement of geothermal borehole heat exchangers performances by improvement of bentonite grouts conductivity, Applied Thermal Engineering 33-34, pp. 92-99 Diao N., Li Q., Fang Z., 2004, Heat transfer in

  17. Fractal Analysis of Stress Sensitivity of Permeability in Porous Media

    Science.gov (United States)

    Tan, Xiao-Hua; Li, Xiao-Ping; Liu, Jian-Yi; Zhang, Lie-Hui; Cai, Jianchao

    2015-12-01

    A permeability model for porous media considering the stress sensitivity is derived based on mechanics of materials and the fractal characteristics of solid cluster size distribution. The permeability of porous media considering the stress sensitivity is related to solid cluster fractal dimension, solid cluster fractal tortuosity dimension, solid cluster minimum diameter and solid cluster maximum diameter, Young's modulus, Poisson's ratio, as well as power index. Every parameter has clear physical meaning without the use of empirical constants. The model predictions of permeability show good agreement with those obtained by the available experimental expression. The proposed model may be conducible to a better understanding of the mechanism for flow in elastic porous media.

  18. Application of Sensitivity Analysis in Design of Sustainable Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per; Brohus, Henrik; Rasmussen, Henrik

    2009-01-01

    satisfies the design objectives and criteria. In the design of sustainable buildings, it is beneficial to identify the most important design parameters in order to more efficiently develop alternative design solutions or reach optimized design solutions. Sensitivity analyses make it possible to identify...... the most important parameters in relation to building performance and to focus design and optimization of sustainable buildings on these fewer, but most important parameters. The sensitivity analyses will typically be performed at a reasonably early stage of the building design process, where it is still...

  19. Preliminary Safety Analysis Report for the Transuranic Storage Area Retrieval Enclosure at the Idaho National Engineering Laboratory. Revision 8

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    This Transuranic Storage Area Retrieval Enclosure Preliminary Safety Analysis Report was completed as required by DOE Order 5480.23. The purpose of this document is to construct a safety basis that supports the design and permits construction of the facility. The facility has been designed to the requirements of a Radioactive Solid Waste Facility presented in DOE Order 6430.1A.

  20. Waste Feed Delivery System Phase 1 Preliminary Reliability and Availability and Maintainability Analysis [SEC 1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    CARLSON, A.B.

    1999-11-11

    The document presents updated results of the preliminary reliability, availability, maintainability analysis performed for delivery of waste feed from tanks 241-AZ-101 and 241-AN-105 to British Nuclear Fuels Limited, inc. under the Tank Waste Remediation System Privatization Contract. The operational schedule delay risk is estimated and contributing factors are discussed.

  1. Sensitivity analysis of airport noise using computer simulation

    Directory of Open Access Journals (Sweden)

    Flavio Maldonado Bentes

    2011-09-01

    Full Text Available This paper presents the method to analyze the sensitivity of airport noise using computer simulation with the aid of Integrated Noise Model 7.0. The technique serves to support the selection of alternatives to better control aircraft noise, since it helps identify which areas of the noise curves experienced greater variation from changes in aircraft movements at a particular airport.

  2. A preliminary assessment of using a white light confocal imaging profiler for cut mark analysis.

    Science.gov (United States)

    Schmidt, Christopher W; Moore, Christopher R; Leifheit, Randell

    2012-01-01

    White light confocal microscopy creates detailed 3D representations of microsurfaces that can be qualitatively and quantitatively analyzed. The study describes its application to the analysis of cut marks on bone, particularly when discerning cuts made by steel tools from those made by stone. The process described comes from a study where cuts were manually made on a cow rib with seven cutting tools, four stone (an unmodified chert flake, a chert biface, a bifacially ground slate fragment, and an unsharpened piece of slate), and three steel (a Swiss Army Knife, a serrate steak knife, and a serrate saw). Kerfs were magnified ×20 and 3D data clouds were generated using a Sensofar(®) White Light Confocal Profiler (WLCP). Kerf profiles and surface areas, volumes, mean depths, and maximum depths were calculated with proprietary software (SensoScan(®) and SolarMap(®)). For the most part, the stone tools make shallower and wider cuts. Kerf floors can be studied at higher magnifications; they were viewed at ×100. When comparing the kerf floors of the unsharpened slate and the serrate steak knife it was found that the slate floor was more uneven, but the serrate steak knife generated more overall relief. Although preliminary, the approach described here successfully distinguishes stone and steel tools; the authors conclude that the WLCP is a promising technology for cut mark analysis because of the very detailed 3D representations it creates and the numerous avenues of analysis it provides.

  3. Preliminary Drop Time Analysis of a Control Rod Using CFD Code

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Myoung Hwan; Park, Jin Seok; Lee, Won Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Park, Jun Hong [SEST Co., Seoul (Korea, Republic of)

    2010-05-15

    A control rod drive mechanism (CRDM) is a reactor regulating system, which can insert and withdraw a control rod containing a neutron absorbing material to control the reactivity of the reactor core. The latch type CRDM for the SMART (System-integrated Modular Advanced ReacTor) is going to be used. The drop time of the control rod in the design stage is one of important parameters for a safety analysis of the reactor. When the control rod is falling down into the core, it is retarded by various forces acting on it such as fluid resistance buoyancy and mechanical friction caused by contacting the inner surface of the guide thimble, etc.. However, complicated coupling of the various forces makes it difficult to predict the drop behavior. This paper describes the development of the 3D CFD analysis model using a FLUENT code. The single control rod of the Westinghouse 17x17 type optimized fuel assembly (W-OFA) was considered for the verification of the CFD model. A preliminary drop time analysis for the SMART with the simulated control rod was performed

  4. A Most Probable Point-Based Method for Reliability Analysis, Sensitivity Analysis and Design Optimization

    Science.gov (United States)

    Hou, Gene J.-W.; Gumbert, Clyde R.; Newman, Perry A.

    2004-01-01

    A major step in a most probable point (MPP)-based method for reliability analysis is to determine the MPP. This is usually accomplished by using an optimization search algorithm. The optimal solutions associated with the MPP provide measurements related to safety probability. This study focuses on two commonly used approximate probability integration methods; i.e., the Reliability Index Approach (RIA) and the Performance Measurement Approach (PMA). Their reliability sensitivity equations are first derived in this paper, based on the derivatives of their respective optimal solutions. Examples are then provided to demonstrate the use of these derivatives for better reliability analysis and Reliability-Based Design Optimization (RBDO).

  5. A Preliminary Analysis of Precipitation Properties and Processes during NASA GPM IFloodS

    Science.gov (United States)

    Carey, Lawrence; Gatlin, Patrick; Petersen, Walt; Wingo, Matt; Lang, Timothy; Wolff, Dave

    2014-01-01

    The Iowa Flood Studies (IFloodS) is a NASA Global Precipitation Measurement (GPM) ground measurement campaign, which took place in eastern Iowa from May 1 to June 15, 2013. The goals of the field campaign were to collect detailed measurements of surface precipitation using ground instruments and advanced weather radars while simultaneously collecting data from satellites passing overhead. Data collected by the radars and other ground instruments, such as disdrometers and rain gauges, will be used to characterize precipitation properties throughout the vertical column, including the precipitation type (e.g., rain, graupel, hail, aggregates, ice crystals), precipitation amounts (e.g., rain rate), and the size and shape of raindrops. The impact of physical processes, such as aggregation, melting, breakup and coalescence on the measured liquid and ice precipitation properties will be investigated. These ground observations will ultimately be used to improve rainfall estimates from satellites and in particular the algorithms that interpret raw data for the upcoming GPM mission's Core Observatory satellite, which launches in 2014. The various precipitation data collected will eventually be used as input to flood forecasting models in an effort to improve capabilities and test the utility and limitations of satellite precipitation data for flood forecasting. In this preliminary study, the focus will be on analysis of NASA NPOL (S-band, polarimetric) radar (e.g., radar reflectivity, differential reflectivity, differential phase, correlation coefficient) and NASA 2D Video Disdrometers (2DVDs) measurements. Quality control and processing of the radar and disdrometer data sets will be outlined. In analyzing preliminary cases, particular emphasis will be placed on 1) documenting the evolution of the rain drop size distribution (DSD) as a function of column melting processes and 2) assessing the impact of range on ground-based polarimetric radar estimates of DSD properties.

  6. Application of sensitivity analysis in building energy simulations: combining first and second order elementary effects Methods

    CERN Document Server

    Sanchez, David Garcia; Musy, Marjorie; Bourges, Bernard

    2012-01-01

    Sensitivity analysis plays an important role in the understanding of complex models. It helps to identify influence of input parameters in relation to the outputs. It can be also a tool to understand the behavior of the model and then can help in its development stage. This study aims to analyze and illustrate the potential usefulness of combining first and second-order sensitivity analysis, applied to a building energy model (ESP-r). Through the example of a collective building, a sensitivity analysis is performed using the method of elementary effects (also known as Morris method), including an analysis of interactions between the input parameters (second order analysis). Importance of higher-order analysis to better support the results of first order analysis, highlighted especially in such complex model. Several aspects are tackled to implement efficiently the multi-order sensitivity analysis: interval size of the variables, management of non-linearity, usefulness of various outputs.

  7. Survey of sampling-based methods for uncertainty and sensitivity analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Jay Dean; Helton, Jon Craig; Sallaberry, Cedric J. PhD. (.; .); Storlie, Curt B. (Colorado State University, Fort Collins, CO)

    2006-06-01

    Sampling-based methods for uncertainty and sensitivity analysis are reviewed. The following topics are considered: (1) Definition of probability distributions to characterize epistemic uncertainty in analysis inputs, (2) Generation of samples from uncertain analysis inputs, (3) Propagation of sampled inputs through an analysis, (4) Presentation of uncertainty analysis results, and (5) Determination of sensitivity analysis results. Special attention is given to the determination of sensitivity analysis results, with brief descriptions and illustrations given for the following procedures/techniques: examination of scatterplots, correlation analysis, regression analysis, partial correlation analysis, rank transformations, statistical tests for patterns based on gridding, entropy tests for patterns based on gridding, nonparametric regression analysis, squared rank differences/rank correlation coefficient test, two dimensional Kolmogorov-Smirnov test, tests for patterns based on distance measures, top down coefficient of concordance, and variance decomposition.

  8. Sensitivity analysis of the GNSS derived Victoria plate motion

    Science.gov (United States)

    Apolinário, João; Fernandes, Rui; Bos, Machiel

    2014-05-01

    Fernandes et al. (2013) estimated the angular velocity of the Victoria tectonic block from geodetic data (GNSS derived velocities) only.. GNSS observations are sparse in this region and it is therefore of the utmost importance to use the available data (5 sites) in the most optimal way. Unfortunately, the existing time-series were/are affected by missing data and offsets. In addition, some time-series were close to the considered minimal threshold value to compute one reliable velocity solution: 2.5-3.0 years. In this research, we focus on the sensitivity of the derived angular velocity to changes in the data (longer data-span for some stations) by extending the used data-span: Fernandes et al. (2013) used data until September 2011. We also investigate the effect of adding other stations to the solution, which is now possible since more stations became available in the region. In addition, we study if the conventional power-law plus white noise model is indeed the best stochastic model. In this respect, we apply different noise models using HECTOR (Bos et al. (2013), which can use different noise models and estimate offsets and seasonal signals simultaneously. The seasonal signal estimation is also other important parameter, since the time-series are rather short or have large data spans at some stations, which implies that the seasonal signals still can have some effect on the estimated trends as shown by Blewitt and Lavellee (2002) and Bos et al. (2010). We also quantify the magnitude of such differences in the estimation of the secular velocity and their effect in the derived angular velocity. Concerning the offsets, we investigate how they can, detected and undetected, influence the estimated plate motion. The time of offsets has been determined by visual inspection of the time-series. The influence of undetected offsets has been done by adding small synthetic random walk signals that are too small to be detected visually but might have an effect on the

  9. Sensitivity analysis in the WWTP modelling community – new opportunities and applications

    DEFF Research Database (Denmark)

    Sin, Gürkan; Ruano, M.V.; Neumann, Marc B.

    2010-01-01

    A mainstream viewpoint on sensitivity analysis in the wastewater modelling community is that it is a first-order differential analysis of outputs with respect to the parameters – typically obtained by perturbing one parameter at a time with a small factor. An alternative viewpoint on sensitivity ...

  10. Distributed Evaluation of Local Sensitivity Analysis (DELSA), with application to hydrological models

    NARCIS (Netherlands)

    Rakovec, O.; Hill, M.C.; Clark, M.P.; Weerts, A.H.; Teuling, A.J.; Uijlenhoet, R.

    2014-01-01

    1] This paper presents a hybrid local-global sensitivity analysis method termed the Distributed Evaluation of Local Sensitivity Analysis (DELSA), which is used here to identify important and unimportant parameters and evaluate how model parameter importance changes as parameter values change. DELSA

  11. Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Stanton L.; Guenther, Richard H.; Sit, Tim L.; Swartz, Paul D.; Meilleur, Flora; Lommel, Steven A.; Rose, Robert B. (NCSU)

    2010-11-12

    Red clover necrotic mosaic virus (RCNMV) is a species that belongs to the Tombusviridae family of plant viruses with a T = 3 icosahedral capsid. RCNMV virions were purified and were crystallized for X-ray analysis using the hanging-drop vapor-diffusion method. Self-rotation functions and systematic absences identified the space group as I23, with two virions in the unit cell. The crystals diffracted to better than 4 {angstrom} resolution but were very radiation-sensitive, causing rapid decay of the high-resolution reflections. The data were processed to 6 {angstrom} in the analysis presented here.

  12. Long vs. short-term energy storage:sensitivity analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Schoenung, Susan M. (Longitude 122 West, Inc., Menlo Park, CA); Hassenzahl, William V. (,Advanced Energy Analysis, Piedmont, CA)

    2007-07-01

    This report extends earlier work to characterize long-duration and short-duration energy storage technologies, primarily on the basis of life-cycle cost, and to investigate sensitivities to various input assumptions. Another technology--asymmetric lead-carbon capacitors--has also been added. Energy storage technologies are examined for three application categories--bulk energy storage, distributed generation, and power quality--with significant variations in discharge time and storage capacity. Sensitivity analyses include cost of electricity and natural gas, and system life, which impacts replacement costs and capital carrying charges. Results are presented in terms of annual cost, $/kW-yr. A major variable affecting system cost is hours of storage available for discharge.

  13. Sensitivity Factor Analysis For Unit Commitment In Loaded Lines

    Directory of Open Access Journals (Sweden)

    Lata Chaudhary

    2016-05-01

    Full Text Available In today’s competitive electricity market, it is not possible to settle all contracted transactions of power because of congestion in transmission lines. Usually, the independent system operator seeks to eliminate congestion by rescheduling output power of the generators. But all generators may not have the same effect (sensitivity on the power flow of the congested lines, so this is not an economical way to reschedule output power of all generators for managing congestion. Therefore, in this paper, active power generator sensitivity factor of the generators to the congested lines have been utilized to ascertain the number of generators participating in congestion management. The effectiveness and feasibility of the proposed algorithm have been tested on IEEE 30 bus system

  14. New test and analysis of position-sensitive-silicon-detector

    Institute of Scientific and Technical Information of China (English)

    FENG Lang; GE Vu-Cheng; WANG He; FAN Feng-Ying; QIAO Rui; LU Fei; SONG Yu-Shou; ZHENG Tao; YE Yan-Lin

    2009-01-01

    We have tested and analyzed the properties of two-dimensional Position-Sensitive-silicon-Detector (PSD) with new integrated preamplifiers.The test demonstrates that the best position resolution for 5.5 MeV α particles is 1.7 mm (FWHM),and the best energy resolution is 2.1%,which are notably better than the previously reported results.A scaling formula is introduced to make the absolute position calibration.

  15. Optimization and Sensitivity Analysis for a Launch Trajectory

    Science.gov (United States)

    2014-12-01

    Finding solutions to a boundary value problem can be time consuming and difficult due to the twin curses of sensitivity and dimensionality. In an...Hamiltonian boundary value problem. Finding solutions to a boundary value problem can be time consuming and difficult due to the twin curses of...case performance to be identified. This knowledge will lead to more flexibility in the launch window and a more reliable launch trajectory. D

  16. Computational aspects of sensitivity calculations in transient structural analysis

    Science.gov (United States)

    Greene, William H.; Haftka, Raphael T.

    1988-01-01

    A key step in the application of formal automated design techniques to structures under transient loading is the calculation of sensitivities of response quantities to the design parameters. This paper considers structures with general forms of damping acted on by general transient loading and addresses issues of computational errors and computational efficiency. The equations of motion are reduced using the traditional basis of vibration modes and then integrated using a highly accurate, explicit integration technique. A critical point constraint formulation is used to place constraints on the magnitude of each response quantity as a function of time. Three different techniques for calculating sensitivities of the critical point constraints are presented. The first two are based on the straightforward application of the forward and central difference operators, respectively. The third is based on explicit differentiation of the equations of motion. Condition errors, finite difference truncation errors, and modal convergence errors for the three techniques are compared by applying them to a simple five-span-beam problem. Sensitivity results are presented for two different transient loading conditions and for both damped and undamped cases.

  17. Sensitivity Analysis and Optimization of Aerodynamic Configurations with Blend Surfaces

    Science.gov (United States)

    Thomas, A. M.; Tiwari, S. N.

    1997-01-01

    A novel (geometrical) parametrization procedure using solutions to a suitably chosen fourth order partial differential equation is used to define a class of airplane configurations. Inclusive in this definition are surface grids, volume grids, and grid sensitivity. The general airplane configuration has wing, fuselage, vertical tail and horizontal tail. The design variables are incorporated into the boundary conditions, and the solution is expressed as a Fourier series. The fuselage has circular cross section, and the radius is an algebraic function of four design parameters and an independent computational variable. Volume grids are obtained through an application of the Control Point Form method. A graphic interface software is developed which dynamically changes the surface of the airplane configuration with the change in input design variable. The software is made user friendly and is targeted towards the initial conceptual development of any aerodynamic configurations. Grid sensitivity with respect to surface design parameters and aerodynamic sensitivity coefficients based on potential flow is obtained using an Automatic Differentiation precompiler software tool ADIFOR. Aerodynamic shape optimization of the complete aircraft with twenty four design variables is performed. Unstructured and structured volume grids and Euler solutions are obtained with standard software to demonstrate the feasibility of the new surface definition.

  18. Sensitivity analysis of bi-layered ceramic dental restorations.

    Science.gov (United States)

    Zhang, Zhongpu; Zhou, Shiwei; Li, Qing; Li, Wei; Swain, Michael V

    2012-02-01

    The reliability and longevity of ceramic prostheses have become a major concern. The existing studies have focused on some critical issues from clinical perspectives, but more researches are needed to address fundamental sciences and fabrication issues to ensure the longevity and durability of ceramic prostheses. The aim of this paper was to explore how "sensitive" the thermal and mechanical responses, in terms of changes in temperature and thermal residual stress of the bi-layered ceramic systems and crown models will be with respect to the perturbation of the design variables chosen (e.g. layer thickness and heat transfer coefficient) in a quantitative way. In this study, three bi-layered ceramic models with different geometries are considered: (i) a simple bi-layered plate, (ii) a simple bi-layer triangle, and (iii) an axisymmetric bi-layered crown. The layer thickness and convective heat transfer coefficient (or cooling rate) seem to be more sensitive for the porcelain fused on zirconia substrate models. The resultant sensitivities indicate a critical importance of the heat transfer coefficient and thickness ratio of core to veneer on the temperature distributions and residual stresses in each model. The findings provide a quantitative basis for assessing the effects of fabrication uncertainties and optimizing the design of ceramic prostheses. Copyright © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  19. Adjoint based sensitivity analysis of a reacting jet in crossflow

    Science.gov (United States)

    Sashittal, Palash; Sayadi, Taraneh; Schmid, Peter

    2016-11-01

    With current advances in computational resources, high fidelity simulations of reactive flows are increasingly being used as predictive tools in various industrial applications. In order to capture the combustion process accurately, detailed/reduced chemical mechanisms are employed, which in turn rely on various model parameters. Therefore, it would be of great interest to quantify the sensitivities of the predictions with respect to the introduced models. Due to the high dimensionality of the parameter space, methods such as finite differences which rely on multiple forward simulations prove to be very costly and adjoint based techniques are a suitable alternative. The complex nature of the governing equations, however, renders an efficient strategy in finding the adjoint equations a challenging task. In this study, we employ the modular approach of Fosas de Pando et al. (2012), to build a discrete adjoint framework applied to a reacting jet in crossflow. The developed framework is then used to extract the sensitivity of the integrated heat release with respect to the existing combustion parameters. Analyzing the sensitivities in the three-dimensional domain provides insight towards the specific regions of the flow that are more susceptible to the choice of the model.

  20. Overview of Sensitivity Analysis and Shape Optimization for Complex Aerodynamic Configurations

    Science.gov (United States)

    Newman, Perry A.; Newman, James C., III; Barnwell, Richard W.; Taylor, Arthur C., III; Hou, Gene J.-W.

    1998-01-01

    This paper presents a brief overview of some of the more recent advances in steady aerodynamic shape-design sensitivity analysis and optimization, based on advanced computational fluid dynamics. The focus here is on those methods particularly well- suited to the study of geometrically complex configurations and their potentially complex associated flow physics. When nonlinear state equations are considered in the optimization process, difficulties are found in the application of sensitivity analysis. Some techniques for circumventing such difficulties are currently being explored and are included here. Attention is directed to methods that utilize automatic differentiation to obtain aerodynamic sensitivity derivatives for both complex configurations and complex flow physics. Various examples of shape-design sensitivity analysis for unstructured-grid computational fluid dynamics algorithms are demonstrated for different formulations of the sensitivity equations. Finally, the use of advanced, unstructured-grid computational fluid dynamics in multidisciplinary analyses and multidisciplinary sensitivity analyses within future optimization processes is recommended and encouraged.

  1. Preliminary analysis of Stearoyl Co-A Desaturase gene transcripts in River buffalo

    Directory of Open Access Journals (Sweden)

    L. Ramunno

    2010-02-01

    Full Text Available Stearoyl-CoA desaturase (SCD is a key enzyme in the biosynthesis of monounsaturated fatty acids (MUFAs. In cattle, SCD gene extends over a DNA segment of ~17.0 Kb, and it is organized in 6 exons and 5 introns. The SCD gene has been indicated as the candidate gene to change the saturated/unsaturated FAs ratio and hence it has been suggested as the gene influencing the fat quality. In cattle, eight SNPs have been identified and one of them, (T→C at 231st nt of 5th exon, is responsible for the Val→Ala amino acid change. The C allele has been associated with higher content of MUFAs in carcasses, and it is positively related to a higher index of desaturation (C18:0/C18:1 and C16:0/C16:1 in the milk. In this study, we report on preliminary results of analysis of transcripts of the SCD encoding gene in river buffalo. The electrophoretic analysis of the RT-PCR products and the subsequent sequencing showed at least five different populations of mRNA. The most represented population is correctly assembled (~1300 bp, followed by the one which is deleted of ~750bp, corresponding to the 3rd, 4th and 5th exon and partially to the 2nd and 6th exon.

  2. Biomarkers of Eating Disorders Using Support Vector Machine Analysis of Structural Neuroimaging Data: Preliminary Results.

    Science.gov (United States)

    Cerasa, Antonio; Castiglioni, Isabella; Salvatore, Christian; Funaro, Angela; Martino, Iolanda; Alfano, Stefania; Donzuso, Giulia; Perrotta, Paolo; Gioia, Maria Cecilia; Gilardi, Maria Carla; Quattrone, Aldo

    2015-01-01

    Presently, there are no valid biomarkers to identify individuals with eating disorders (ED). The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM) technique, combined with a pattern recognition method, was employed utilizing structural magnetic resonance images. Seventeen females with ED (six with diagnosis of anorexia nervosa and 11 with bulimia nervosa) were compared against 17 body mass index-matched healthy controls (HC). Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80. Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED. Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.

  3. Biomarkers of Eating Disorders Using Support Vector Machine Analysis of Structural Neuroimaging Data: Preliminary Results

    Directory of Open Access Journals (Sweden)

    Antonio Cerasa

    2015-01-01

    Full Text Available Presently, there are no valid biomarkers to identify individuals with eating disorders (ED. The aim of this work was to assess the feasibility of a machine learning method for extracting reliable neuroimaging features allowing individual categorization of patients with ED. Support Vector Machine (SVM technique, combined with a pattern recognition method, was employed utilizing structural magnetic resonance images. Seventeen females with ED (six with diagnosis of anorexia nervosa and 11 with bulimia nervosa were compared against 17 body mass index-matched healthy controls (HC. Machine learning allowed individual diagnosis of ED versus HC with an Accuracy ≥ 0.80. Voxel-based pattern recognition analysis demonstrated that voxels influencing the classification Accuracy involved the occipital cortex, the posterior cerebellar lobule, precuneus, sensorimotor/premotor cortices, and the medial prefrontal cortex, all critical regions known to be strongly involved in the pathophysiological mechanisms of ED. Although these findings should be considered preliminary given the small size investigated, SVM analysis highlights the role of well-known brain regions as possible biomarkers to distinguish ED from HC at an individual level, thus encouraging the translational implementation of this new multivariate approach in the clinical practice.

  4. The 6 April 2009 earthquake at L'Aquila: a preliminary analysis of magnetic field measurements

    Directory of Open Access Journals (Sweden)

    U. Villante

    2010-02-01

    Full Text Available Several investigations reported the possible identification of anomalous geomagnetic field signals prior to earthquake occurrence. In the ULF frequency range, candidates for precursory signatures have been proposed in the increase in the noise background and polarization parameter (i.e. the ratio between the amplitude/power of the vertical component and that one of the horizontal component, in the changing characteristics of the slope of the power spectrum and fractal dimension, in the possible occurrence of short duration pulses. We conducted, with conventional techniques of data processing, a preliminary analysis of the magnetic field observations performed at L'Aquila during three months preceding the 6 April 2009 earthquake, focusing attention on the possible occurrence of features similar to those identified in previous events. Within the limits of this analysis, we do not find compelling evidence for any of the features which have been proposed as earthquake precursors: indeed, most of aspects of our observations (which, in some cases, appear consistent with previous findings might be interpreted in terms of the general magnetospheric conditions and/or of different sources.

  5. Crystallization and preliminary X-ray diffraction analysis of human adenovirus

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, V.S.; Natchiar, S.K.; Gritton, L.; Mullen, T.-M.; Stewart, P.L.; Nemerow, G.R. (Scripps); (Vanderbilt)

    2010-07-22

    Replication-defective and conditionally replicating adenovirus (AdV) vectors are currently being utilized in {approx}25% of human gene transfer clinical trials. Unfortunately, progress in vector development has been hindered by a lack of accurate structural information. Here we describe the crystallization and preliminary X-ray diffraction analysis of a HAdV5 vector that displays a short flexible fiber derived from HAdV35. Crystals of Ad35F were grown in 100 mM HEPES pH 7.0, 200 mM Ca(OAc){sub 2}, 14% PEG 550 MME, 15% glycerol in 100 mM Tris-HCl 8.5. Freshly grown crystals diffracted well to 4.5 {angstrom} resolution and weakly to 3.5 {angstrom} at synchrotron sources. HAdV crystals belong to space group P1 with unit cell parameters a = 854.03 {angstrom}, b = 855.17 {angstrom}, c = 865.24 {angstrom}, {alpha} = 119.57{sup o}, {beta} = 91.71{sup o}, {gamma} = 118.08{sup o} with a single particle in the unit cell. Self-rotation and locked-rotation function analysis allowed the determination of the particle orientation. Molecular replacement, density modification and phase-extension procedures are being employed for structure determination.

  6. Ocean thermal energy conversion cold water pipe preliminary design project. Task 2. Analysis for concept selection

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-04-01

    The successful performance of the CWP is of crucial importance to the overall OTEC system; the pipe itself is considered the most critical part of the entire operation. Because of the importance the CWP, a project for the analysis and design of CWP's was begun in the fall of 1978. The goals of this project were to study a variety of concepts for delivering cold water to an OTEC plant, to analyze and rank these concepts based on their relative cost and risk, and to develop preliminary design for those concepts which seemed most promising. Two representative platforms and sites were chosen: a spar buoy of a Gibbs and Cox design to be moored at a site off Punta Tuna, Puerto Rico, and a barge designed by APL/Johns Hopkins University, grazing about a site approximately 200 miles east of the coast of Brazil. The approach was to concentrate on the most promising concepts and on those which were either of general interest or espoused by others (e.g., steel and concrete concepts). Much of the overall attention, therefore, focused on analyzing rigid and compliant wall design, while stockade (except for the special case of the FRP stockade) and bottom-mounted concepts received less attention. A total of 67 CWP concepts were initially generated and subjected to a screening process. Of these, 16 were carried through design analysis, costing, and ranking. Study results are presented in detail. (WHK)

  7. Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis.

    Directory of Open Access Journals (Sweden)

    Hanni S M Kiiski

    Full Text Available Conduction along the optic nerve is often slowed in multiple sclerosis (MS. This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response analogous to the P100 but with a higher signal-to-noise ratio and potentially higher sensitivity to individual differences in comparison to the VEP. The main objective of the study was to conduct a preliminary investigation into the utility of the VESPA method for probing and monitoring visual dysfunction in multiple sclerosis. The latencies and amplitudes of the P100-like VESPA component were compared between healthy controls and multiple sclerosis patients, and multiple sclerosis subgroups. The P100-like VESPA component activations were examined at baseline and over a 3-year period. The study included 43 multiple sclerosis patients (23 relapsing-remitting MS, 20 secondary-progressive MS and 42 healthy controls who completed the VESPA at baseline. The follow-up sessions were conducted 12 months after baseline with 24 MS patients (15 relapsing-remitting MS, 9 secondary-progressive MS and 23 controls, and again at 24 months post-baseline with 19 MS patients (13 relapsing-remitting MS, 6 secondary-progressive MS and 14 controls. The results showed P100-like VESPA latencies to be delayed in multiple sclerosis compared to healthy controls over the 24-month period. Secondary-progressive MS patients had most pronounced delay in P100-like VESPA latency relative to relapsing-remitting MS and controls. There were no longitudinal P100-like VESPA response differences. These findings suggest that the VESPA method is a reproducible electrophysiological method that may have potential utility in the assessment of visual dysfunction in multiple sclerosis.

  8. Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis

    Science.gov (United States)

    Kiiski, Hanni S. M.; Ní Riada, Sinéad; Lalor, Edmund C.; Gonçalves, Nuno R.; Nolan, Hugh; Whelan, Robert; Lonergan, Róisín; Kelly, Siobhán; O'Brien, Marie Claire; Kinsella, Katie; Bramham, Jessica; Burke, Teresa; Ó Donnchadha, Seán; Hutchinson, Michael; Tubridy, Niall; Reilly, Richard B.

    2016-01-01

    Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA) method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response analogous to the P100 but with a higher signal-to-noise ratio and potentially higher sensitivity to individual differences in comparison to the VEP. The main objective of the study was to conduct a preliminary investigation into the utility of the VESPA method for probing and monitoring visual dysfunction in multiple sclerosis. The latencies and amplitudes of the P100-like VESPA component were compared between healthy controls and multiple sclerosis patients, and multiple sclerosis subgroups. The P100-like VESPA component activations were examined at baseline and over a 3-year period. The study included 43 multiple sclerosis patients (23 relapsing-remitting MS, 20 secondary-progressive MS) and 42 healthy controls who completed the VESPA at baseline. The follow-up sessions were conducted 12 months after baseline with 24 MS patients (15 relapsing-remitting MS, 9 secondary-progressive MS) and 23 controls, and again at 24 months post-baseline with 19 MS patients (13 relapsing-remitting MS, 6 secondary-progressive MS) and 14 controls. The results showed P100-like VESPA latencies to be delayed in multiple sclerosis compared to healthy controls over the 24-month period. Secondary-progressive MS patients had most pronounced delay in P100-like VESPA latency relative to relapsing-remitting MS and controls. There were no longitudinal P100-like VESPA response differences. These findings suggest that the VESPA method is a reproducible electrophysiological method that may have potential utility in the assessment of visual dysfunction in multiple sclerosis. PMID:26726800

  9. Implementation of terbium-sensitized luminescence in sequential-injection analysis for automatic analysis of orbifloxacin.

    Science.gov (United States)

    Llorent-Martínez, E J; Ortega-Barrales, P; Molina-Díaz, A; Ruiz-Medina, A

    2008-12-01

    Orbifloxacin (ORBI) is a third-generation fluoroquinolone developed exclusively for use in veterinary medicine, mainly in companion animals. This antimicrobial agent has bactericidal activity against numerous gram-negative and gram-positive bacteria. A few chromatographic methods for its analysis have been described in the scientific literature. Here, coupling of sequential-injection analysis and solid-phase spectroscopy is described in order to develop, for the first time, a terbium-sensitized luminescent optosensor for analysis of ORBI. The cationic resin Sephadex-CM C-25 was used as solid support and measurements were made at 275/545 nm. The system had a linear dynamic range of 10-150 ng mL(-1), with a detection limit of 3.3 ng mL(-1) and an R.S.D. below 3% (n = 10). The analyte was satisfactorily determined in veterinary drugs and dog and horse urine.

  10. Gene expression analysis identifies global gene dosage sensitivity in cancer

    DEFF Research Database (Denmark)

    Fehrmann, Rudolf S. N.; Karjalainen, Juha M.; Krajewska, Malgorzata;

    2015-01-01

    expression. We reanalyzed 77,840 expression profiles and observed a limited set of 'transcriptional components' that describe well-known biology, explain the vast majority of variation in gene expression and enable us to predict the biological function of genes. On correcting expression profiles...... for these components, we observed that the residual expression levels (in 'functional genomic mRNA' profiling) correlated strongly with copy number. DNA copy number correlated positively with expression levels for 99% of all abundantly expressed human genes, indicating global gene dosage sensitivity. By applying...

  11. Sensitivity Analysis of MEMS Flexure FET with Multiple Gates

    Directory of Open Access Journals (Sweden)

    K.Spandana

    2016-02-01

    Full Text Available This paper deals with the design and modelling of Flexure FET and the FETs are the one of the important fundamental devices in electronic devices.. In this paper we are going analyse one of the MEMS Flexure Gate Field Effect Transistors. Here we will design gate of the FLEXURE FET with different type of materials and with different structure and we made the comparison between all the structures. We apply pull-in voltage to the Gate with respect to the change in the gate voltage the respective displacement of the gate changes which reflect the change in the drain current and sensitivity.

  12. A Flow-Sensitive Analysis of Privacy Properties

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming

    2007-01-01

    that information I send to some service never is leaked to another service? - unless I give my permission? We shall develop a static program analysis for the pi- calculus and show how it can be used to give privacy guarantees like the ones requested above. The analysis records the explicit information flow...

  13. Sensitivity Analysis of the ALMANAC Model's Input Variables

    Institute of Scientific and Technical Information of China (English)

    XIE Yun; James R.Kiniry; Jimmy R.Williams; CHEN You-min; LIN Er-da

    2002-01-01

    Crop models often require extensive input data sets to realistically simulate crop growth. Development of such input data sets can be difficult for some model users. The objective of this study was to evaluate the importance of variables in input data sets for crop modeling. Based on published hybrid performance trials in eight Texas counties, we developed standard data sets of 10-year simulations of maize and sorghum for these eight counties with the ALMANAC (Agricultural Land Management Alternatives with Numerical Assessment Criteria) model. The simulation results were close to the measured county yields with relative error only 2.6%for maize, and - 0.6% for sorghum. We then analyzed the sensitivity of grain yield to solar radiation, rainfall, soil depth, soil plant available water, and runoff curve number, comparing simulated yields to those with the original, standard data sets. Runoff curve number changes had the greatest impact on simulated maize and sorghum yields for all the counties. The next most critical input was rainfall, and then solar radiation for both maize and sorghum, especially for the dryland condition. For irrigated sorghum, solar radiation was the second most critical input instead of rainfall. The degree of sensitivity of yield to all variables for maize was larger than for sorghum except for solar radiation. Many models use a USDA curve number approach to represent soil water redistribution, so it will be important to have accurate curve numbers, rainfall, and soil depth to realistically simulate yields.

  14. Iris Recognition for Partially Occluded Images: Methodology and Sensitivity Analysis

    Science.gov (United States)

    Poursaberi, A.; Araabi, B. N.

    2006-12-01

    Accurate iris detection is a crucial part of an iris recognition system. One of the main issues in iris segmentation is coping with occlusion that happens due to eyelids and eyelashes. In the literature, some various methods have been suggested to solve the occlusion problem. In this paper, two different segmentations of iris are presented. In the first algorithm, a circle is located around the pupil with an appropriate diameter. The iris area encircled by the circular boundary is used for recognition purposes then. In the second method, again a circle is located around the pupil with a larger diameter. This time, however, only the lower part of the encircled iris area is utilized for individual recognition. Wavelet-based texture features are used in the process. Hamming and harmonic mean distance classifiers are exploited as a mixed classifier in suggested algorithm. It is observed that relying on a smaller but more reliable part of the iris, though reducing the net amount of information, improves the overall performance. Experimental results on CASIA database show that our method has a promising performance with an accuracy of 99.31%. The sensitivity of the proposed method is analyzed versus contrast, illumination, and noise as well, where lower sensitivity to all factors is observed when the lower half of the iris is used for recognition.

  15. Sensitivity analysis of fluid-structure interaction problems

    Energy Technology Data Exchange (ETDEWEB)

    Etienne, S.; Pelletier, D. [Ecole Polytechnique de Montreal, Montreal, Quebec (Canada)]. E-mail: stephane.etienne@polymtl.ca

    2004-07-01

    Interactions between solids and fluids (FSI) have been a topic of interest for engineers for many years. The behavior of vessels subject to wave loads, of planes in flight condition as well as submarine or transmission lines are but a few examples. In an attempt to address these problems, the present paper presents a formulation which allows to treat interactions between an incompressible flow and a structure undergoing large displacements. We assume existence and unicity of the solution. The interested reader is referred, for a mathematical discussion of existence and unicity. The approach to coupling can be addressed in two ways: weakly-coupled methods for which algorithms for structure and fluid are segregated, as is commonly done for simplicity and often because engineers have access to existing structural and fluid codes; and tightly-coupled or monolithic methods, for which the formulation guarantees satisfaction of equilibrium of the interface between the fluid and the solid. The latter has been chosen as it allows for quadratic convergence of Newton's method. The paper begins with the description of the steady state governing equations for laminar incompressible fluids, hyperelastic solid behaviour, pseudo-solid mapping and fluid-structure interfaces. The weak forms of the equations are then presented. We proceed with the description of the continuous sensitivity equations for fluid-structure interactions problems. The following sections detail the adaptive finite element procedure for the fluid-structure interaction and sensitivity problems. Results are presented and the paper ends with conclusions and discussions. (author)

  16. Iris Recognition for Partially Occluded Images: Methodology and Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    A. Poursaberi

    2007-01-01

    Full Text Available Accurate iris detection is a crucial part of an iris recognition system. One of the main issues in iris segmentation is coping with occlusion that happens due to eyelids and eyelashes. In the literature, some various methods have been suggested to solve the occlusion problem. In this paper, two different segmentations of iris are presented. In the first algorithm, a circle is located around the pupil with an appropriate diameter. The iris area encircled by the circular boundary is used for recognition purposes then. In the second method, again a circle is located around the pupil with a larger diameter. This time, however, only the lower part of the encircled iris area is utilized for individual recognition. Wavelet-based texture features are used in the process. Hamming and harmonic mean distance classifiers are exploited as a mixed classifier in suggested algorithm. It is observed that relying on a smaller but more reliable part of the iris, though reducing the net amount of information, improves the overall performance. Experimental results on CASIA database show that our method has a promising performance with an accuracy of 99.31%. The sensitivity of the proposed method is analyzed versus contrast, illumination, and noise as well, where lower sensitivity to all factors is observed when the lower half of the iris is used for recognition.

  17. Reactive Aggression and Suicide-Related Behaviors in Children and Adolescents: A Review and Preliminary Meta-Analysis.

    Science.gov (United States)

    Hartley, Chelsey M; Pettit, Jeremy W; Castellanos, Daniel

    2017-01-03

    The empirical literature on the association between reactive aggression and suicide-related behaviors in children and adolescents was reviewed. A narrative review of seven studies that met inclusion/exclusion criteria is followed by a preliminary meta-analysis to provide insight into the strength of the association between reactive aggression and suicide-related behaviors. Each of the seven studies reported a statistically significant association between reactive aggression and suicide-related behaviors, including suicide, nonfatal suicide attempt, and suicide ideation. Results from the meta-analysis indicated a consistent, medium-sized association (k = 7; N = 4,693; rbar = .25). The narrative review and results of the preliminary meta-analysis support the promise of pursuing future research on reactive aggression and suicide-related behaviors in children and adolescents. A theoretical model is proposed to guide the development of future research.

  18. Report on preliminary analysis of state of nuclear criticality accident at JCO at Tokaimura, Ibaraki, Japan (I)

    Energy Technology Data Exchange (ETDEWEB)

    Ha, J.J.; Park, J.H.; Chang, J.H. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-10-01

    This preliminary report was prepared by the Special Task Force Team of KAERI in order to analysis status of nuclear criticality accident broken out at 10:35 September 30, 1999 at JCO nuclear conversion test facility located at Tokaimura, Ibaraki, Japan. The report was consisted of accident summary of cause of accident summary of cause of accident and response by relevant organizations, and preliminary technical analysis of radiation exposure of JCO workers, analysis of cause of accident, and accident assessment and preventive actions against criticality accident. It is expected that JCO accident, Japan's first nuclear criticality accident, would make significant effects to Japan nuclear policy and would be also a good example to Korea future actions to be taken in use and development of nuclear energy. 63 refs., 3 figs., 1 tab. (Author)

  19. Investigation of Utilizing a Secant Stiffness Matrix for 2D Nonlinear Shape Optimization and Sensitivity Analysis

    Directory of Open Access Journals (Sweden)

    Asghar Vatani Oskouie

    2016-12-01

    Full Text Available In this article the general non-symmetric parametric form of the incremental secant stiffness matrix for nonlinear analysis of solids have been investigated to present a semi analytical sensitivity analysis approach for geometric nonlinear shape optimization. To approach this aim the analytical formulas of secant stiffness matrix are presented. The models were validated and used to perform investigating different parameters affecting the shape optimization. Numerical examples utilized for this investigating sensitivity analysis with detailed discussions presented.

  20. Preliminary results on the EUCLID NISP stray-light and ghost analysis

    Science.gov (United States)

    Geis, Norbert; Grupp, Frank; Prieto, Eric; Bender, Ralf

    2015-09-01

    The EUCLID mission within the European Space Agencies 2015 - 2025 Cosmic Vision framework addresses cosmological questions related to dark matter and dark energy. EUCLID is equipped with two instruments that are simultaneously observing patches of > 0:5 square degree on the sky. The VIS visual light high spacial resolution imager and the NISP near infrared spectrometer and photometer are separated by a di-chroic beam splitter. With its large FoV (larger than the full moon disk), together with high demands on the optical performance and strong requirements on in flight stability lead to very challenging demands on alignment and post launch { post cool-down optical element position. In addition the demanding requirements from spectroscopy and galaxy photometry lead to a highly demanding stray light and ghost control need. With this paper we present a preliminary - PDR level - analysis of ghosting and stray light levels in the EUCLID NISP near infrared spectrometer and photometer. The analysis presented focuses on the photometric channel, as this, together with the wide field of the instrument, shows most of the challenges and features of the instrument. As one requirement is to have a non vignetting design, extensive baffling is not possible, and only secondary and higher order light can be actively baffled. A comprehensive ZEMAX based analysis is being presented, showing in summary that baffles are only necessary due to the EUCLID fine guiding sensors auxiliary fields of view. The total level of contaminating light is thereafter dominated by stray light from dust on the lenses. Ghosts play a minor role.

  1. Variational Methods in Design Optimization and Sensitivity Analysis for Two-Dimensional Euler Equations

    Science.gov (United States)

    Ibrahim, A. H.; Tiwari, S. N.; Smith, R. E.

    1997-01-01

    Variational methods (VM) sensitivity analysis employed to derive the costate (adjoint) equations, the transversality conditions, and the functional sensitivity derivatives. In the derivation of the sensitivity equations, the variational methods use the generalized calculus of variations, in which the variable boundary is considered as the design function. The converged solution of the state equations together with the converged solution of the costate equations are integrated along the domain boundary to uniquely determine the functional sensitivity derivatives with respect to the design function. The application of the variational methods to aerodynamic shape optimization problems is demonstrated for internal flow problems at supersonic Mach number range. The study shows, that while maintaining the accuracy of the functional sensitivity derivatives within the reasonable range for engineering prediction purposes, the variational methods show a substantial gain in computational efficiency, i.e., computer time and memory, when compared with the finite difference sensitivity analysis.

  2. Analysis on sensitivity and landscape ecological spatial structure of site resources

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This article establishes a set of indicators and standards for landscape ecological sensitivity analysis of site resources by using thetheories and approaches of landscape ecology.It uses landscape diversity index( H), evenness(E), natural degree(N), contrast degree(C)to study spatial structure and landscape heterogeneity of site resources and thus provides a qualitative-quantitative evaluation method for landplanning and management of small, medium scale areas.The analysis of Yantian District, Shenzhen of China showed that Wutong Mountainbelonged to high landscape ecological sensitivity area, Sanzhoutian Reservoir and Shangping Reservoir were medium landscape sensitivity areaand high ecological sensitivity area; Dameisha and Xiaomeisha belonged to medium sensitivity area caused by the decline of natural ecologicalareas.Shatoujiao, Yantian Pier belonged to low sensitivity area but urban landscape ecological development had reshaped and influenced theirlandscape ecological roles in a great extent.Suggestions on planning, protection goals and development intensity of each site or district wereraised.

  3. Competitive Comparison of Optimal Designs of Experiments for Sampling-based Sensitivity Analysis

    CERN Document Server

    Janouchova, Eliska

    2012-01-01

    Nowadays, the numerical models of real-world structures are more precise, more complex and, of course, more time-consuming. Despite the growth of a computational effort, the exploration of model behaviour remains a complex task. The sensitivity analysis is a basic tool for investigating the sensitivity of the model to its inputs. One widely used strategy to assess the sensitivity is based on a finite set of simulations for a given sets of input parameters, i.e. points in the design space. An estimate of the sensitivity can be then obtained by computing correlations between the input parameters and the chosen response of the model. The accuracy of the sensitivity prediction depends on the choice of design points called the design of experiments. The aim of the presented paper is to review and compare available criteria determining the quality of the design of experiments suitable for sampling-based sensitivity analysis.

  4. Parameter uncertainty and sensitivity analysis in sediment flux calculation

    Directory of Open Access Journals (Sweden)

    B. Cheviron

    2011-01-01

    Full Text Available This paper examines uncertainties in the calculation of annual sediment budgets at the outlet of rivers. Emphasis is put on the sensitivity of power-law rating curves to degradations of the available discharge-concentration data. The main purpose is to determine how predictions arising from usual or modified power laws resist to the infrequence of concentration data and to relative uncertainties affecting source data. This study identifies cases in which the error on the estimated sediment fluxes remains of the same order of magnitude or even inferior to these in source data, provided the number of concentration data is high enough. The exposed mathematical framework allows considering all limitations at once in further detailed investigations. It is applied here to bound the error on sediment budgets for the major French rivers to the sea.

  5. Crystallization and preliminary X-ray analysis of Chandipura virus glycoprotein G.

    Science.gov (United States)

    Baquero, Eduard; Buonocore, Linda; Rose, John K; Bressanelli, Stéphane; Gaudin, Yves; Albertini, Aurélie A

    2012-09-01

    Fusion in members of the Rhabdoviridae virus family is mediated by the G glycoprotein. At low pH, the G glycoprotein catalyzes fusion between viral and endosomal membranes by undergoing a major conformational change from a pre-fusion trimer to a post-fusion trimer. The structure of the G glycoprotein from vesicular stomatitis virus (VSV G), the prototype of Vesiculovirus, has recently been solved in its trimeric pre-fusion and post-fusion conformations; however, little is known about the structural details of the transition. In this work, a soluble form of the ectodomain of Chandipura virus G glycoprotein (CHAV G(th)) was purified using limited proteolysis of purified virus; this soluble ectodomain was also crystallized. This protein shares 41% amino-acid identity with VSV G and thus its structure could provide further clues about the structural transition of rhabdoviral glycoproteins induced by low pH. Crystals of CHAV G(th) obtained at pH 7.5 diffracted X-rays to 3.1 Å resolution. These crystals belonged to the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 150.3, b = 228.2, c = 78.8 Å. Preliminary analysis of the data based on the space group and the self-rotation function indicated that there was no trimeric association of the protomers. This unusual oligomeric status could result from the presence of fusion intermediates in the crystal.

  6. Preliminary uncertainty analysis of OECD/UAM benchmark for the TMI-1 reactor

    Energy Technology Data Exchange (ETDEWEB)

    Cardoso, Fabiano S.; Faria, Rochkhudson B.; Silva, Lucas M.C.; Pereira, Claubia; Fortini, Angela, E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

    2015-07-01

    Nowadays the demand from nuclear research centers for safety, regulation and better-estimated predictions provided with confidence bounds has been increasing. On that way, studies have pointed out that present uncertainties in the nuclear data should be significantly reduced, to get the full benefit from the advanced modeling and simulation initiatives. The major outcome of NEA/OECD (UAM) workshop took place Italy on 2006, was the preparation of a benchmark work program with steps (exercises) that would be needed to define the uncertainty and modeling tasks. On that direction, this work was performed within the framework of UAM Exercise 1 (I-1) 'Cell Physics' to validate the study, and to be able estimated the accuracies of the model. The objectives of this study were to make a preliminary analysis of criticality values of TMI-1 PWR and the biases of the results from two different nuclear codes multiplication factor. The range of the bias was obtained using the deterministic codes: NEWT (New ESC-based Weighting Transport code), the two-dimensional transport module that uses AMPX-formatted cross-sections processed by other SCALE; and WIMSD5 (Winfrith Improved Multi-Group Scheme) code. The WIMSD5 system consists of a simplified geometric representation of heterogeneous space zones that are coupled with each other and with the boundaries, while the properties of each spacing element are obtained from Carlson DSN method or Collision Probability method. (author)

  7. Global volcanic earthquake swarm database and preliminary analysis of volcanic earthquake swarm duration

    Directory of Open Access Journals (Sweden)

    S. R. McNutt

    1996-06-01

    Full Text Available Global data from 1979 to 1989 pertaining to volcanic earthquake swarms have been compiled into a custom-designed relational database. The database is composed of three sections: 1 a section containing general information on volcanoes, 2 a section containing earthquake swarm data (such as dates of swarm occurrence and durations, and 3 a section containing eruption information. The most abundant and reliable parameter, duration of volcanic earthquake swarms, was chosen for preliminary analysis. The distribution of all swarm durations was found to have a geometric mean of 5.5 days. Precursory swarms were then separated from those not associated with eruptions. The geometric mean precursory swarm duration was 8 days whereas the geometric mean duration of swarms not associated with eruptive activity was 3.5 days. Two groups of precursory swarms are apparent when duration is compared with the eruption repose time. Swarms with durations shorter than 4 months showed no clear relationship with the eruption repose time. However, the second group, lasting longer than 4 months, showed a significant positive correlation with the log10 of the eruption repose period. The two groups suggest that different suites of physical processes are involved in the generation of volcanic earthquake swarms.

  8. In situ fluidization for peat bed rupture, and preliminary economic analysis.

    Science.gov (United States)

    Niven, R K; Khalili, N

    2002-11-01

    This study concerns in situ fluidization (ISF), a new remediation method with potential application to the remediation of NAPL and heavy metal contaminants, by their release from the fluidized zone generated by a water jet. The present study examines the effect of ISF on layers of peat, of significance owing to its role as an important NAPL and metal contaminant trap. Once trapped, such contaminants are not readily accessible by most remedial methods, due to the low permeability and diffusivity of the peat. A simple tank experiment is used to demonstrate rupture of a peat layer by ISF, with removal of the peat as elutriated fines and segregated peat chunks. The application of ISF in the field is then examined by three field trials in uncontaminated sands, in both saturated and unsaturated conditions. Fluidized depths of up to 1.9 m in the saturated zone (with refusal on a peat layer) and 2.5 m in the unsaturated zone (no refusal) were attained, using a 1.9-m-long, 50 mm diameter jet operated at 5-13 1 s(-1). Pulses of dark turbidity and shell fragments in the effluent indicated the rupture of peat and shelly layers. The experiments demonstrate the hydraulic viability of ISF in the field, and its ability to remove peat-based contaminants. The issues of appropriate jet design and water generation during ISF are discussed, followed by a preliminary economic analysis of ISF relative to existing remediation methods.

  9. Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from Thalictrum flavum

    Energy Technology Data Exchange (ETDEWEB)

    Pasquo, Alessandra [ENEA Casaccia Research Centre, Dipartimento BIOTEC, Sezione Genetica e Genomica Vegetale, PO Box 2400, I-00100 Rome (Italy); Bonamore, Alessandra; Franceschini, Stefano; Macone, Alberto; Boffi, Alberto; Ilari, Andrea, E-mail: andrea.ilari@uniroma1.it [Istituto di Biologia e Patologia Molecolari, CNR (IBPM) and Department Of Biochemical Sciences, University of Roma ‘La Sapienza’, Piazza Aldo Moro 5, 00179 Roma (Italy); ENEA Casaccia Research Centre, Dipartimento BIOTEC, Sezione Genetica e Genomica Vegetale, PO Box 2400, I-00100 Rome (Italy)

    2008-04-01

    The cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from T. flavum, a protein which catalyzes the first committed step in the biosynthesis of benzylisoquinoline alkaloids, are reported. Norcoclaurine synthase (NCS) catalyzes the condensation of 3,4-dihydroxyphenylethylamine (dopamine) and 4-hydroxyphenylacetaldehyde (4-HPAA) as the first committed step in the biosynthesis of benzylisoquinoline alkaloids in plants. The protein was cloned, expressed and purified. Crystals were obtained at 294 K by the hanging-drop vapour-diffusion method using ammonium sulfate and sodium chloride as precipitant agents and diffract to better than 3.0 Å resolution using a synchrotron-radiation source. The crystals belong to the trigonal space group P3{sub 1}21, with unit-cell parameters a = b = 86.31, c = 118.36 Å. A selenomethionine derivative was overexpressed, purified and crystallized in the same space group. A complete MAD data set was collected at 2.7 Å resolution. The model is under construction.

  10. Acanthamoeba polyphaga mimivirus NDK: preliminary crystallographic analysis of the first viral nucleoside diphosphate kinase

    Energy Technology Data Exchange (ETDEWEB)

    Jeudy, Sandra [Information Génomique et Structurale, CNRS UPR 2589, 31 Chemin Joseph Aiguier, 13402 Marseille CEDEX 20 (France); Coutard, Bruno [Architecture et Fonction des Macromolecules Biologiques, CNRS UMR 6098, 31 Chemin Joseph Aiguier, 13402 Marseille CEDEX 20 (France); Lebrun, Régine [IBSM, 31 Chemin Joseph Aiguier, 13402 Marseille CEDEX 20 (France); Abergel, Chantal, E-mail: chantal.abergel@igs.cnrs-mrs.fr [Information Génomique et Structurale, CNRS UPR 2589, 31 Chemin Joseph Aiguier, 13402 Marseille CEDEX 20 (France)

    2005-06-01

    A. polyphaga mimivirus, the largest known double-stranded DNA virus, is the first virus to exhibit a nucleoside diphosphate kinase gene. The expression and crystallization of the viral NDK are reported. The complete sequence of the largest known double-stranded DNA virus, Acanthamoeba polyphaga mimivirus, has recently been determined [Raoult et al. (2004 ▶), Science, 306, 1344–1350] and revealed numerous genes not expected to be found in a virus. A comprehensive structural and functional study of these gene products was initiated [Abergel et al. (2005 ▶), Acta Cryst. F61, 212–215] both to better understand their role in the virus physiology and to obtain some clues to the origin of DNA viruses. Here, the preliminary crystallographic analysis of the viral nucleoside diphosphate kinase protein is reported. The crystal belongs to the cubic space group P2{sub 1}3, with unit-cell parameter 99.425 Å. The self-rotation function confirms that there are two monomers per asymmetric unit related by a twofold non-crystallographic axis and that the unit cell thus contains four biological entities.

  11. N-Acetyltransferase 2 status and gastric cancer risk: a preliminary meta-analysis

    Directory of Open Access Journals (Sweden)

    Stefania Boccia

    2005-03-01

    Full Text Available

    In recent studies N- Acetyltransferase 2 (NAT2 genotype has been considered as a risk factor for developing gastric cancer, however with conflicting results among Asian and Caucasian populations. In order to clarify the influence of NAT2 slow acetylation status on gastric cancer risk, a preliminary meta-analysis of published case-control studies was undertaken.

    The primary outcome measure was the odds ratio (OR for the risk of gastric cancer associated with the NAT2 slow genotype using a random effects model. Pooling the results from the 5 studies identified (771 cases, 1083 controls, an overall OR for gastric cancer risk associated with the NAT2 slow genotype of 0.91 emerged (95% CI: 0.54-1.55.

    The result suggests that the NAT2 slow genotype has probably no effect on the risk of gastric cancer. Additional epidemiological studies, based on sample sizes that are commensurate with the detection of small genotypic risks, are required to confirm these findings. Future studies may also help to clarify whether geographic differences exist.

  12. Preliminary Analysis of Two Years of the Massive Collision Monitoring Activity

    Science.gov (United States)

    McKnight, Darren; Matney, Mark; Walbert, Kris; Behrend, Sophie; Casey, Patrick; Speaks, Seth

    2017-01-01

    It is hypothesized that the interactions between many of the most massive derelicts in low Earth orbit are more frequent than modeled by the traditional combination of kinetic theory of gases and Poisson probability distribution function. This is suggested by the fact that there are clusters of derelicts where members' inclinations are nearly identical and their apogees/perigees overlap significantly resulting in periodic synchronization of the objects' orbits. In order to address this proposition, an experiment was designed and conducted over the last two years. Results from this monitoring and characterization experiment are presented with implications for proposed debris remediation strategies. Four separate clusters of massive derelicts were examined that are centered around 775km, 850km, 975km, and 1500km, respectively. In aggregate, the constituents of these clusters contain around 500 objects and about 800,000kg of mass; this equates to a third of all derelict mass in LEO. Preliminary analysis indicates that encounter rates over this time period for these objects are greater than is estimated by traditional techniques. Hypothesized dependencies between latitude of encounter, relative velocity, frequency of encounters, inclination, and differential semi-major axis were established and verified. This experiment also identified specific repeatable cluster dynamics that may reduce the cost/risk and enhance the effectiveness of debris remediation activities and also enable new operational debris remediation options.

  13. GC-MS Analysis and Preliminary Antimicrobial Activity of Albizia adianthifolia (Schumach and Pterocarpus angolensis (DC

    Directory of Open Access Journals (Sweden)

    Mustapha N. Abubakar

    2016-01-01

    Full Text Available The non-polar components of two leguminoceae species Albizia adianthifolia (Schumach, and Pterocarpus angolensis (DC were investigated. GC-MS analysis of the crude n-hexane and chloroform extracts together with several chromatographic separation techniques led to the identification and characterization (using NMR of sixteen known compounds from the heartwood and stem bark of Albizia adianthifolia and Pterocarpus angolensis respectively. These constituents include, n-hexadecanoic acid (palmitic acid 1, oleic acid 2, chondrillasterol 3, stigmasterol 4, 24S 5α-stigmast-7-en-3β-ol 5, 9,12-octadecadienoic acid (Z,Z-, methyl ester 6, trans-13-octadecanoic acid, methyl ester 7, tetradecanoic acid 8, hexadecanoic acid, methyl ester 9, octadecanoic acid 10, tetratriacontane 11, 7-dehydrodiosgenin 12, lupeol 13, stigmasta-3,5-diene-7-one 14, friedelan-3-one (friedelin 15, and 1-octacosanol 16. Using agar over lay method, the preliminary antimicrobial assay for the extracts was carried out against bacterial (E. coli, P. aeruginosa, B. subtilis, S. aueus and a fungus/yeast (C. albicans strains. The n-hexane and chloroform extracts of A. adianthifolia showed the best activity against E. coli with minimum inhibition quantity (MIQ of 1 µg each while the remaining exhibited moderate-to-weak activity against the test microorganisms.

  14. Satellite geological and geophysical remote sensing of Iceland: Preliminary results from analysis of MSS imagery

    Science.gov (United States)

    Williams, R. S., Jr.; Boedvarsson, A.; Fridriksson, S.; Palmason, G.; Rist, S.; Sigtryggsson, H.; Thorarinsson, S.; Thorsteinsson, I.

    1973-01-01

    A binational, multidisciplinary research effort in Iceland is directed at an analysis of MSS imagery from ERTS-1 to study a variety of geologic, hydrologic, oceanographic, and agricultural phenomena. A preliminary evaluation of available MSS imagery of Iceland has yielded several significant results - some of which may have direct importance to the Icelandic economy. Initial findings can be summarized as follows: (1) recent lava flows can be delineated from older flows at Askja and Hekla; (2) MSS imagery from ERTS-1 and VHRR visible and infrared imagery from NOAA-2 recorded the vocanic eruption on Heimaey, Vestmann Islands; (3) coastline changes, particularly changes in the position of bars and beaches along the south coast are mappable; and (4) areas covered with new and residual snow can be mapped, and the appearance of newly fallen snow on ERTS-1, MSS band 7 appears dark where it is melting. ERTS-1 imagery provides a means of updating various types of maps of Iceland and will permit the compilation of special maps specifically aimed at those dynamic environmental phenomena which impact on the Icelandic economy.

  15. Analysis of the preliminary optical links between ARTEMIS and the Optical Ground Station

    Science.gov (United States)

    Reyes Garcia-Talavera, Marcos; Chueca, Sergio; Alonso, Angel; Viera, Teodora; Sodnik, Zoran

    2002-12-01

    In the frame of the SILEX project, the European Space Agency (ESA) has put into orbit two Laser Communication Terminals, to establish an experimental free space optical communication link between a GEO satellite (ARTEMIS) and a LEO satellite (SPOT IV), to relay earth observation data. In order to perform In Orbit Testing (IOT) of these, and other, optical communications systems, ESA and the Instituto de Astrofisica de Canarias (IAC) reached an agreement for building the Optical Ground Station (OGS), in the Teide Observatory of the IAC. With ARTEMIS placed in a circular parking orbit at about 31000 kilometres, its optical payload has been preliminary tested with the OGS. First results and analysis are presented on the space-to-ground bi-directional link, including pointing acquisition and tracking performance, Bit-Error Rate (BER) and transmitted beam divergence effects related with atmospheric models and predictions. Future plans include deeper optical bi-directional communication tests of OGS, not only with ARTEMIS but also with OSCAR-40 (downlink) and SMART-1 (up-link) satellites, in order to do a full characterisation of the performances of laser beam propagation through atmospheric turbulence and a comparison with theoretical predictions.

  16. Marine Traffic Density Over Port Klang, Malaysia Using Statistical Analysis of AIS Data: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Masnawi MUSTAFFA

    2016-12-01

    Full Text Available Port Klang Malaysia is the 13th busiest port in the world, the capacity at the port expected to be able to meet the demand until 2018. It is one of the busiest ports in the world and also the busiest port in Malaysia. Even though there are statistics published by Port Klang Authority showing that a lot of ships using this port, this number is only based on ships that entering Port Klang. Therefore, no study has been done to investigate on how dense the traffic is in Port Klang, Malaysia the surrounding sea including Strait of Malacca . This paper has investigated on traffic density over Port Klang Malaysia and its surrounding sea using statistical analysis from AIS data. As a preliminary study, this study only collected AIS data for 7 days to represent daily traffic weekly. As a result, an hourly number of vessels, daily number of vessels, vessels classification and sizes and also traffic paths will be plotted.

  17. GC-MS Analysis and Preliminary Antimicrobial Activity of Albizia adianthifolia (Schumach) and Pterocarpus angolensis (DC).

    Science.gov (United States)

    Abubakar, Mustapha N; Majinda, Runner R T

    2016-01-28

    The non-polar components of two leguminoceae species Albizia adianthifolia (Schumach), and Pterocarpus angolensis (DC) were investigated. GC-MS analysis of the crude n-hexane and chloroform extracts together with several chromatographic separation techniques led to the identification and characterization (using NMR) of sixteen known compounds from the heartwood and stem bark of Albizia adianthifolia and Pterocarpus angolensis respectively. These constituents include, n-hexadecanoic acid (palmitic acid) 1, oleic acid 2, chondrillasterol 3, stigmasterol 4, 24S 5α-stigmast-7-en-3β-ol 5, 9,12-octadecadienoic acid (Z,Z)-, methyl ester 6, trans-13-octadecanoic acid, methyl ester 7, tetradecanoic acid 8, hexadecanoic acid, methyl ester 9, octadecanoic acid 10, tetratriacontane 11, 7-dehydrodiosgenin 12, lupeol 13, stigmasta-3,5-diene-7-one 14, friedelan-3-one (friedelin) 15, and 1-octacosanol 16. Using agar over lay method, the preliminary antimicrobial assay for the extracts was carried out against bacterial (E. coli, P. aeruginosa, B. subtilis, S. aueus) and a fungus/yeast (C. albicans) strains. The n-hexane and chloroform extracts of A. adianthifolia showed the best activity against E. coli with minimum inhibition quantity (MIQ) of 1 µg each while the remaining exhibited moderate-to-weak activity against the test microorganisms.

  18. Bioinformatics analysis of the gene expression profile of hepatocellular carcinoma: preliminary results

    Science.gov (United States)

    Li, Jia

    2016-01-01

    Aim of the study To analyse the expression profile of hepatocellular carcinoma compared with normal liver by using bioinformatics methods. Material and methods In this study, we analysed the microarray expression data of HCC and adjacent normal liver samples from the Gene Expression Omnibus (GEO) database to screen for differentially expressed genes. Then, functional analyses were performed using GenCLiP analysis, Gene Ontology categories, and aberrant pathway identification. In addition, we used the CMap database to identify small molecules that can induce HCC. Results Overall, 2721 differentially expressed genes (DEGs) were identified. We found 180 metastasis-related genes and constructed co-occurrence networks. Several significant pathways, including the transforming growth factor β (TGF-β) signalling pathway, were identified as closely related to these DEGs. Some candidate small molecules (such as betahistine) were identified that might provide a basis for developing HCC treatments in the future. Conclusions Although we functionally analysed the differences in the gene expression profiles of HCC and normal liver tissues, our study is essentially preliminary, and it may be premature to apply our results to clinical trials. Further research and experimental testing are required in future studies. PMID:27095935

  19. Occupant evaluation of commercial office lighting: Volume 2, Preliminary data analysis

    Energy Technology Data Exchange (ETDEWEB)

    Marans, R.W.; Brown, M.A. (ed.)

    1987-11-01

    This report presents the preliminary results of a post-occupancy evaluation of office lighting environments. It explores the relationship between quantitative measures of lighting in occupied environments and qualitative measures related to occupant satisfaction. The report analyzes several types of data from more than 1000 occupied work stations: subjective data on attitudes and ratings of selected lighting and other characteristics, photometric and other direct environmental data, including illuminances, luminances, and contrast conditions, indirect environmental measures obtained from the architectural drawings and the work station photographs, and descriptive characteristics of the occupants. The work stations were sampled from thirteen office buildings located in various cities in the United States. Many tentative findings emerged from the analysis, including the following: (1) within the range of values examined here, there is a tendency for lighting satisfaction to decrease as lighting power density increases; (2) occupants who described their work station spaces as bright also tended to be satisfied with their work station lighting; (3) occupants who were most bothered by bright lights and glare were most likely to express dissatisfaction with the lighting at their work stations; (4) there is no relationship between work-related activities of employees and indicators of lighting quality. More research is needed before firm conclusions can be drawn and before guidance regarding lighting standards and other policy issues can be derived. 3 refs., 9 figs.

  20. Hydrothermal Liquefaction and Upgrading of Municipal Wastewater Treatment Plant Sludge: A Preliminary Techno-Economic Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Snowden-Swan, Lesley J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhu, Yunhua [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Jones, Susanne B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Elliott, Douglas C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schmidt, Andrew J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hallen, Richard T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Billing, Justin M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hart, Todd R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fox, Samuel P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Maupin, Gary D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-06-08

    A preliminary process model and techno-economic analysis (TEA) was completed for fuel produced from hydrothermal liquefaction (HTL) of sludge waste from a municipal wastewater treatment plant (WWTP) and subsequent biocrude upgrading. The model is adapted from previous work by Jones et al. (2014) for algae HTL, using experimental data generated in fiscal year 2015 (FY15) bench-scale HTL testing of sludge waste streams. Testing was performed on sludge samples received from MetroVancouver’s Annacis Island WWTP (Vancouver, B.C.) as part of a collaborative project with the Water Environment and Reuse Foundation (WERF). The full set of sludge HTL testing data from this effort will be documented in a separate report to be issued by WERF. This analysis is based on limited testing data and therefore should be considered preliminary. Future refinements are necessary to improve the robustness of the model, including a cross-check of modeled biocrude components with the experimental GCMS data and investigation of equipment costs most appropriate at the smaller scales used here. Environmental sustainability metrics analysis is also needed to understand the broader impact of this technology pathway. The base case scenario for the analysis consists of 10 HTL plants, each processing 100 dry U.S. ton/day (92.4 ton/day on a dry, ash-free basis) of sludge waste and producing 234 barrel per stream day (BPSD) biocrude, feeding into a centralized biocrude upgrading facility that produces 2,020 barrel per standard day of final fuel. This scale was chosen based upon initial wastewater treatment plant data collected by the resource assessment team from the EPA’s Clean Watersheds Needs Survey database (EPA 2015a) and a rough estimate of what the potential sludge availability might be within a 100-mile radius. In addition, we received valuable feedback from the wastewater treatment industry as part of the WERF collaboration that helped form the basis for the selected HTL and upgrading

  1. Comprehensive mechanisms for combustion chemistry: Experiment, modeling, and sensitivity analysis

    Energy Technology Data Exchange (ETDEWEB)

    Dryer, F.L.; Yetter, R.A. [Princeton Univ., NJ (United States)

    1993-12-01

    This research program is an integrated experimental/numerical effort to study pyrolysis and oxidation reactions and mechanisms for small-molecule hydrocarbon structures under conditions representative of combustion environments. The experimental aspects of the work are conducted in large diameter flow reactors, at pressures from one to twenty atmospheres, temperatures from 550 K to 1200 K, and with observed reaction times from 10{sup {minus}2} to 5 seconds. Gas sampling of stable reactant, intermediate, and product species concentrations provides not only substantial definition of the phenomenology of reaction mechanisms, but a significantly constrained set of kinetic information with negligible diffusive coupling. Analytical techniques used for detecting hydrocarbons and carbon oxides include gas chromatography (GC), and gas infrared (NDIR) and FTIR methods are utilized for continuous on-line sample detection of light absorption measurements of OH have also been performed in an atmospheric pressure flow reactor (APFR), and a variable pressure flow (VPFR) reactor is presently being instrumented to perform optical measurements of radicals and highly reactive molecular intermediates. The numerical aspects of the work utilize zero and one-dimensional pre-mixed, detailed kinetic studies, including path, elemental gradient sensitivity, and feature sensitivity analyses. The program emphasizes the use of hierarchical mechanistic construction to understand and develop detailed kinetic mechanisms. Numerical studies are utilized for guiding experimental parameter selections, for interpreting observations, for extending the predictive range of mechanism constructs, and to study the effects of diffusive transport coupling on reaction behavior in flames. Modeling using well defined and validated mechanisms for the CO/H{sub 2}/oxidant systems.

  2. Models for patients' recruitment in clinical trials and sensitivity analysis.

    Science.gov (United States)

    Mijoule, Guillaume; Savy, Stéphanie; Savy, Nicolas

    2012-07-20

    Taking a decision on the feasibility and estimating the duration of patients' recruitment in a clinical trial are very important but very hard questions to answer, mainly because of the huge variability of the system. The more elaborated works on this topic are those of Anisimov and co-authors, where they investigate modelling of the enrolment period by using Gamma-Poisson processes, which allows to develop statistical tools that can help the manager of the clinical trial to answer these questions and thus help him to plan the trial. The main idea is to consider an ongoing study at an intermediate time, denoted t(1). Data collected on [0,t(1)] allow to calibrate the parameters of the model, which are then used to make predictions on what will happen after t(1). This method allows us to estimate the probability of ending the trial on time and give possible corrective actions to the trial manager especially regarding how many centres have to be open to finish on time. In this paper, we investigate a Pareto-Poisson model, which we compare with the Gamma-Poisson one. We will discuss the accuracy of the estimation of the parameters and compare the models on a set of real case data. We make the comparison on various criteria : the expected recruitment duration, the quality of fitting to the data and its sensitivity to parameter errors. We discuss the influence of the centres opening dates on the estimation of the duration. This is a very important question to deal with in the setting of our data set. In fact, these dates are not known. For this discussion, we consider a uniformly distributed approach. Finally, we study the sensitivity of the expected duration of the trial with respect to the parameters of the model : we calculate to what extent an error on the estimation of the parameters generates an error in the prediction of the duration.

  3. Glaucoma progression detection: agreement, sensitivity, and specificity of expert visual field evaluation, event analysis, and trend analysis.

    Science.gov (United States)

    Antón, Alfonso; Pazos, Marta; Martín, Belén; Navero, José Manuel; Ayala, Miriam Eleonora; Castany, Marta; Martínez, Patricia; Bardavío, Javier

    2013-01-01

    To assess sensitivity, specificity, and agreement among automated event analysis, automated trend analysis, and expert evaluation to detect glaucoma progression. This was a prospective study that included 37 eyes with a follow-up of 36 months. All had glaucomatous disks and fields and performed reliable visual fields every 6 months. Each series of fields was assessed with 3 different methods: subjective assessment by 2 independent teams of glaucoma experts, glaucoma/guided progression analysis (GPA) event analysis, and GPA (visual field index-based) trend analysis. Kappa agreement coefficient between methods and sensitivity and specificity for each method using expert opinion as gold standard were calculated. The incidence of glaucoma progression was 16% to 18% in 3 years but only 3 cases showed progression with all 3 methods. Kappa agreement coefficient was high (k=0.82) between subjective expert assessment and GPA event analysis, and only moderate between these two and GPA trend analysis (k=0.57). Sensitivity and specificity for GPA event and GPA trend analysis were 71% and 96%, and 57% and 93%, respectively. The 3 methods detected similar numbers of progressing cases. The GPA event analysis and expert subjective assessment showed high agreement between them and moderate agreement with GPA trend analysis. In a period of 3 years, both methods of GPA analysis offered high specificity, event analysis showed 83% sensitivity, and trend analysis had a 66% sensitivity.

  4. Brook trout (Salvelinus fontinalis extinction in small boreal lakes revealed by ephippia pigmentation: a preliminary analysis

    Directory of Open Access Journals (Sweden)

    Alexandre Bérubé Tellier

    2016-12-01

    Full Text Available Ephippium pigmentation is a plastic trait which can be related to a trade-off between visual predation pressure and better protection of cladoceran eggs against different types of stress. Experimental studies showed that planktivorous fish exert a greater predation pressure on individuals carrying darker ephippia, but little is known about the variation of ephippium pigmentation along gradients of fish predation pressure in natural conditions. For this study, our experimental design included four small boreal lakes with known fish assemblages. Two of the lakes have viable brook trout (Salvelinus fontinalis populations, whereas the other two lakes experienced brook trout extinctions during the 20th century. Cladoceran ephippia were extracted from sediment cores at layers corresponding to the documented post- extinction phase (1990's and from an older layer (1950's for which the brook trout population status is not known precisely. Our first objective was to determine whether brook trout extinction has a direct effect on both ephippium pigmentation and size. Our second objective was to give a preliminary assessment of the status of brook trout populations in the 1950's by comparing the variation in ephippia traits measured from this layer to those measured in the 1990's, for which the extinction patterns are well known. Cost-effective image analysis was used to assess variation in pigmentation levels in ephippia. This approach provided a proxy for the amount of melanin invested in each ephippium analysed. Our study clearly shows that ephippium pigmentation may represent a better indicator of the presence of fish predators than ephippium size, a trait that showed a less clear pattern of variation between lakes with and without fish. For the 1990's period, ephippia from fishless lakes were darker and showed a slight tendency to be larger than ephippia from lakes with brook trout. However, no clear differences in either ephippium size or pigmentation

  5. Uncertainty analysis and global sensitivity analysis of techno-economic assessments for biodiesel production.

    Science.gov (United States)

    Tang, Zhang-Chun; Zhenzhou, Lu; Zhiwen, Liu; Ningcong, Xiao

    2015-01-01

    There are various uncertain parameters in the techno-economic assessments (TEAs) of biodiesel production, including capital cost, interest rate, feedstock price, maintenance rate, biodiesel conversion efficiency, glycerol price and operating cost. However, fewer studies focus on the influence of these parameters on TEAs. This paper investigated the effects of these parameters on the life cycle cost (LCC) and the unit cost (UC) in the TEAs of biodiesel production. The results show that LCC and UC exhibit variations when involving uncertain parameters. Based on the uncertainty analysis, three global sensitivity analysis (GSA) methods are utilized to quantify the contribution of an individual uncertain parameter to LCC and UC. The GSA results reveal that the feedstock price and the interest rate produce considerable effects on the TEAs. These results can provide a useful guide for entrepreneurs when they plan plants.

  6. MELCOR Sensitivity Analysis Focusing on the Heat Source

    Energy Technology Data Exchange (ETDEWEB)

    Maeng, Yunhwan; Sung, Joonyoung; Lee, Jaeyoung [Handong Global Univ., Pohang (Korea, Republic of)

    2015-10-15

    Present study conducted MELCOR code calculation by assuming the situation of complete loss of coolant accident (LOCA) scenario in a PWR 17 x 17 single spent fuel assembly, not an overall spent fuel pool. Present study conducted MELCOR analysis focusing on the heat source (decay heat, oxidation heat) and analysis object was PWR 17x17 spent nuclear fuel assembly. By changing the decay heat and oxidation coefficient, variation of peak cladding temperature to the time of the fuel assembly was analyzed. Different oxidation coefficient results the difference on the initiating time and existence of zirconium fire. From the result of MELCOR analysis, we found the criteria of decay heat that MELCOR simulation result showed the disagreement of peak cladding temperature, about 5.0 kW - 10.0 kW range.

  7. Preliminary Analysis of Effects of Reduced Discharge onThermal Habitat of Pedersen Warm Springs Channel

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A preliminary report to study the potential impacts of possible flow reductions in thermal spring systems located in the Warm Springs area of Moapa Valley NWR on the...

  8. Parameter identification and global sensitivity analysis of Xinanjiang model using meta-modeling approach

    Directory of Open Access Journals (Sweden)

    Xiao-meng SONG

    2013-01-01

    Full Text Available Parameter identification, model calibration, and uncertainty quantification are important steps in the model-building process, and are necessary for obtaining credible results and valuable information. Sensitivity analysis of hydrological model is a key step in model uncertainty quantification, which can identify the dominant parameters, reduce the model calibration uncertainty, and enhance the model optimization efficiency. There are, however, some shortcomings in classical approaches, including the long duration of time and high computation cost required to quantitatively assess the sensitivity of a multiple-parameter hydrological model. For this reason, a two-step statistical evaluation framework using global techniques is presented. It is based on (1 a screening method (Morris for qualitative ranking of parameters, and (2 a variance-based method integrated with a meta-model for quantitative sensitivity analysis, i.e., the Sobol method integrated with the response surface model (RSMSobol. First, the Morris screening method was used to qualitatively identify the parameters’ sensitivity, and then ten parameters were selected to quantify the sensitivity indices. Subsequently, the RSMSobol method was used to quantify the sensitivity, i.e., the first-order and total sensitivity indices based on the response surface model (RSM were calculated. The RSMSobol method can not only quantify the sensitivity, but also reduce the computational cost, with good accuracy compared to the classical approaches. This approach will be effective and reliable in the global sensitivity analysis of a complex large-scale distributed hydrological model.

  9. Radiolysis Model Sensitivity Analysis for a Used Fuel Storage Canister

    Energy Technology Data Exchange (ETDEWEB)

    Wittman, Richard S.

    2013-09-20

    This report fulfills the M3 milestone (M3FT-13PN0810027) to report on a radiolysis computer model analysis that estimates the generation of radiolytic products for a storage canister. The analysis considers radiolysis outside storage canister walls and within the canister fill gas over a possible 300-year lifetime. Previous work relied on estimates based directly on a water radiolysis G-value. This work also includes that effect with the addition of coupled kinetics for 111 reactions for 40 gas species to account for radiolytic-induced chemistry, which includes water recombination and reactions with air.

  10. Sensitivity Analysis of the Bone Fracture Risk Model

    Science.gov (United States)

    Lewandowski, Beth; Myers, Jerry; Sibonga, Jean Diane

    2017-01-01

    Introduction: The probability of bone fracture during and after spaceflight is quantified to aid in mission planning, to determine required astronaut fitness standards and training requirements and to inform countermeasure research and design. Probability is quantified with a probabilistic modeling approach where distributions of model parameter values, instead of single deterministic values, capture the parameter variability within the astronaut population and fracture predictions are probability distributions with a mean value and an associated uncertainty. Because of this uncertainty, the model in its current state cannot discern an effect of countermeasures on fracture probability, for example between use and non-use of bisphosphonates or between spaceflight exercise performed with the Advanced Resistive Exercise Device (ARED) or on devices prior to installation of ARED on the International Space Station. This is thought to be due to the inability to measure key contributors to bone strength, for example, geometry and volumetric distributions of bone mass, with areal bone mineral density (BMD) measurement techniques. To further the applicability of model, we performed a parameter sensitivity study aimed at identifying those parameter uncertainties that most effect the model forecasts in order to determine what areas of the model needed enhancements for reducing uncertainty. Methods: The bone fracture risk model (BFxRM), originally published in (Nelson et al) is a probabilistic model that can assess the risk of astronaut bone fracture. This is accomplished by utilizing biomechanical models to assess the applied loads; utilizing models of spaceflight BMD loss in at-risk skeletal locations; quantifying bone strength through a relationship between areal BMD and bone failure load; and relating fracture risk index (FRI), the ratio of applied load to bone strength, to fracture probability. There are many factors associated with these calculations including

  11. Pharmacognostic and Preliminary Phytochemical Analysis of Sauropus androgynus (L) Merr. Leaf

    OpenAIRE

    Ankad Gireesh; Hegde Harsha; Kholkute S.D; Hurkadale Pramod

    2013-01-01

    The leaves of Sauropus androgynus (L.) Merr. are used in traditional medicine to treat various disorders and also used as vegetable for its nutritive value. Such plant having medicinal and nutritive values lacks pharmacognostical and preliminary phytochemical information. Hence the present work is intended to study pharmacognostical and preliminary phytochemical studies, which will serve as quality control parameters. The pharmacognostical parameters like transverse section of midrib, epiderm...

  12. Volume analysis of heat-induced cracks in human molars: A preliminary study

    Directory of Open Access Journals (Sweden)

    Michael A. Sandholzer

    2014-01-01

    Full Text Available Context: Only a few methods have been published dealing with the visualization of heat-induced cracks inside bones and teeth. Aims : As a novel approach this study used nondestructive X-ray microtomography (micro-CT for volume analysis of heat-induced cracks to observe the reaction of human molars to various levels of thermal stress. Materials and Methods: Eighteen clinically extracted third molars were rehydrated and burned under controlled temperatures (400, 650, and 800°C using an electric furnace adjusted with a 25°C increase/min. The subsequent high-resolution scans (voxel-size 17.7 μm were made with a compact micro-CT scanner (SkyScan 1174. In total, 14 scans were automatically segmented with Definiens XD Developer 1.2 and three-dimensional (3D models were computed with Visage Imaging Amira 5.2.2. The results of the automated segmentation were analyzed with an analysis of variance (ANOVA and uncorrected post hoc least significant difference (LSD tests using Statistical Package for Social Sciences (SPSS 17. A probability level of P < 0.05 was used as an index of statistical significance. Results: A temperature-dependent increase of heat-induced cracks was observed between the three temperature groups (P < 0.05, ANOVA post hoc LSD. In addition, the distributions and shape of the heat-induced changes could be classified using the computed 3D models. Conclusion: The macroscopic heat-induced changes observed in this preliminary study correspond with previous observations of unrestored human teeth, yet the current observations also take into account the entire microscopic 3D expansions of heat-induced cracks within the dental hard tissues. Using the same experimental conditions proposed in the literature, this study confirms previous results, adds new observations, and offers new perspectives in the investigation of forensic evidence.

  13. Preliminary design of a small air loop for system analysis and validation of Cathare code

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, M.; Saez, M.; Tauveron, N.; Tenchine, D.; Germain, T.; Geffraye, G.; Ruby, G.P. [CEA Grenoble (DEN/DER/SSTH), 38 (France)

    2007-07-01

    The French Atomic Energy Commission (Cea) is carrying on the design of a Small Air Loop for System Analysis (SALSA), devoted to the study of gas cooled nuclear reactors behaviour in normal and incidental/accidental operating conditions. The reduced size of the SALSA components compared to a full-scale reactor and air as gaseous coolant instead of Helium will allow an easy management of the loop. The main purpose of SALSA will be the validation of the associated thermal hydraulic safety simulation codes, like CATHARE. The main goal of this paper is to present the methodology used to define the characteristics of the loop. In a first step, the study has been focused on a direct-cycle system for the SALSA loop with few global constraints using a similarity analysis to support the definition and design of the loop. Similarity requirements have been evaluated to determine the scale factors which have to be applied to the SALSA loop components. The preliminary conceptual design of the SALSA plant with a definition of each component has then be carried out. The whole plant has been modelled using the CATHARE code. Calculations of the SALSA steady-state in nominal conditions and of different plant transients in direct-cycle have been made. The first system results obtained on the global behaviour of the loop confirm that SALSA can be representative of a Gas-Cooled nuclear reactor with some minor design modifications. In a second step, the current prospects focus on the SALSA loop capability to reproduce correctly the heat transfer occurring in specific incidental situations. Heat decay removal by natural convection is a crucial point of interest. The first results show that the behaviour and the efficiency of the loop are strongly influenced by the definition of the main parameters for each component. A complete definition of SALSA is under progress. (authors)

  14. An evaluation of the Positive Emotional Experiences Scale: A preliminary analysis

    Directory of Open Access Journals (Sweden)

    Rene van Wyk

    2016-04-01

    Full Text Available Orientation: The positive organisational behaviour movement emphasises the advantages of psychological strengths in business. The psychological virtues of positive emotional experiences can potentially promote human strengths to the advantages of business functioning and the management of work conditions. This is supported by Fredrickson’s broaden-and-build theory that emphasises the broadening of reactive thought patterns through experiences of positive emotions.Research purpose: A preliminary psychometric evaluation of a positive measurement of dimensions of emotional experiences in the workplace, by rephrasing the Kiefer and Barclay Toxic Emotional Experiences Scale.Motivation for the study: This quantitative Exploratory Factor Analysis investigates the factorial structure and reliability of the Positive Emotional Experiences Scale, a positive rephrased version of the Toxic Emotional Experiences Scale.Research approach, design and method: This Exploratory Factor Analysis indicates an acceptable three-factor model for the Positive Emotional Experiences Scale. These three factors are: (1 psychological recurrent positive state, (2 social connectedness and (3 physical refreshed energy, with strong Cronbach’s alphas of 0.91, 0.91 and 0.94, respectively.Main findings: The three-factor model of the Positive Emotional Experiences Scale provides a valid measure in support of Fredrickson’s theory of social, physical and psychological endured personal resources that build positive emotions.Practical/Managerial implications: Knowledge gained on positive versus negative emotional experiences could be applied by management to promote endured personal resources that strengthen positive emotional experiences.Contribution/value-add: The contribution of this rephrased Positive Emotional Experiences Scale provides a reliable measure of assessment of the social, physical and endured psychological and personal resources identified in Fredrickson’s broaden

  15. Which preventive interventions effectively enhance depressed mothers' sensitivity? A meta-analysis

    NARCIS (Netherlands)

    Kersten, L.E.; Hosman, C.M.H.; Riksen-Walraven, J.M.A.; Doesum, K.T.M. van; Hoefnagels, C.C.J.

    2011-01-01

    Improving depressed mothers' sensitivity is assumed to be a key element in preventing adverse outcomes for children of such mothers. This meta-analysis examines the short-term effectiveness of preventive interventions in terms of enhancing depressed mothers' sensitivity toward their child and

  16. Sensitivity analysis explains quasi-one-dimensional current transport in two-dimensional materials

    DEFF Research Database (Denmark)

    Boll, Mads; Lotz, Mikkel Rønne; Hansen, Ole;

    2014-01-01

    . The sensitivity analysis presents a formal definition of quasi-1D current transport, which was recently observed experimentally in chemical-vapor-deposition graphene. Our numerical model for calculating sensitivity is verified by comparing the model to analytical calculations based on conformal mapping...

  17. Which preventive interventions effectively enhance depressed mothers' sensitivity? A meta-analysis

    NARCIS (Netherlands)

    Kersten, L.E.; Hosman, C.M.H.; Riksen-Walraven, J.M.A.; Doesum, K.T.M. van; Hoefnagels, C.C.J.

    2011-01-01

    Improving depressed mothers' sensitivity is assumed to be a key element in preventing adverse outcomes for children of such mothers. This meta-analysis examines the short-term effectiveness of preventive interventions in terms of enhancing depressed mothers' sensitivity toward their child and invest

  18. Analysis and implementation of packet preemption for Time Sensitive Networks

    DEFF Research Database (Denmark)

    Zhou, Zifan; Yan, Ying; Ruepp, Sarah Renée

    2017-01-01

    level simulation in Riverbed Modeler. The simulation is complemented by numerical analysis which provides the average queuing delay for both types of traffic (preemptable and express). Furthermore, the paper describes an approach to implement the packet preemption solution on an FPGA in VHDL, which...

  19. Shotgun lipidomic analysis of chemically sulfated sterols compromises analytical sensitivity

    DEFF Research Database (Denmark)

    Casanovas, Albert; Hannibal-Bach, Hans Kristian; Jensen, Ole Nørregaard

    2014-01-01

    Fourier transform mass spectrometry (FTMS) for identification and quantification of lipid species [6]. Shotgun lipidomics affords extensive lipidome coverage by combining the analysis of lipid extracts in positive and negative ion mode [1, 3]. Notably, sterols such as cholesterol and ergosterol exhibit...

  20. Sensitivity Analysis of Mixed Models for Incomplete Longitudinal Data

    Science.gov (United States)

    Xu, Shu; Blozis, Shelley A.

    2011-01-01

    Mixed models are used for the analysis of data measured over time to study population-level change and individual differences in change characteristics. Linear and nonlinear functions may be used to describe a longitudinal response, individuals need not be observed at the same time points, and missing data, assumed to be missing at random (MAR),…