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Sample records for preliminary safety studies

  1. Preliminary planning study for safety relief valve experiments in a Mark III BWR pressure suppression system

    Energy Technology Data Exchange (ETDEWEB)

    McCauley, E.W.; Holman, G.S.

    1980-04-21

    In response to a request from the Water Reactor Safety Research Division of the US NRC, a preliminary study is provided which identifies key features and consideration involved in planning a comprehensive in-plant Safety Relief Valve experimental program for a Mark III containment design. The report provides identification of program objectives, measurement system requirements, and some details quantifying expected system response. In addition, a preliminary test matrix is outlined which involves a supporting philosophy intended to enhance the usefulness of the experimental results for all members of the program team: experimentalists, analysts, and plant operator.

  2. Study of fast reactor safety test facilities. Preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Bell, G.I.; Boudreau, J.E.; McLaughlin, T.; Palmer, R.G.; Starkovich, V.; Stein, W.E.; Stevenson, M.G.; Yarnell, Y.L.

    1975-05-01

    Included are sections dealing with the following topics: (1) perspective and philosophy of fast reactor safety analysis; (2) status of accident analysis and experimental needs; (3) experiment and facility definitions; (4) existing in-pile facilities; (5) new facility options; and (6) data acquisition methods. (DG)

  3. Topaz II preliminary safety assessment

    Science.gov (United States)

    Marshall, Albert C.; Standley, Vaughn; Voss, Susan S.; Haskin, Eric

    1993-01-01

    The Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz II space nuclear power system. A preliminary safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz II activities. A review of the Russian flight safety program was conducted and documented. Our preliminary safety assessment included a top level event tree, neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, and analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment, it appears that it will be possible to safely launch the Topaz II system in the U.S. with some possible system modifications. The principal system modifications will probably include design changes to preclude water flooded criticality and to assure intact reentry.

  4. Safety and feasibility of transcranial direct current stimulation in pediatric hemiparesis: randomized controlled preliminary study.

    Science.gov (United States)

    Gillick, Bernadette T; Feyma, Tim; Menk, Jeremiah; Usset, Michelle; Vaith, Amy; Wood, Teddi Jean; Worthington, Rebecca; Krach, Linda E

    2015-03-01

    Transcranial direct current stimulation (tDCS) is a form of noninvasive brain stimulation that has shown improved adult stroke outcomes. Applying tDCS in children with congenital hemiparesis has not yet been explored. The primary objective of this study was to explore the safety and feasibility of single-session tDCS through an adverse events profile and symptom assessment within a double-blind, randomized placebo-controlled preliminary study in children with congenital hemiparesis. A secondary objective was to assess the stability of hand and cognitive function. A double-blind, randomized placebo-controlled pretest/posttest/follow-up study was conducted. The study was conducted in a university pediatric research laboratory. Thirteen children, ages 7 to 18 years, with congenital hemiparesis participated. Adverse events/safety assessment and hand function were measured. Participants were randomly assigned to either an intervention group or a control group, with safety and functional assessments at pretest, at posttest on the same day, and at a 1-week follow-up session. An intervention of 10 minutes of 0.7 mA tDCS was applied to bilateral primary motor cortices. The tDCS intervention was considered safe if there was no individual decline of 25% or group decline of 2 standard deviations for motor evoked potentials (MEPs) and behavioral data and no report of adverse events. No major adverse events were found, including no seizures. Two participants did not complete the study due to lack of MEP and discomfort. For the 11 participants who completed the study, group differences in MEPs and behavioral data did not exceed 2 standard deviations in those who received the tDCS (n=5) and those in the control group (n=6). The study was completed without the need for stopping per medical monitor and biostatisticial analysis. A limitation of the study was the small sample size, with data available for 11 participants. Based on the results of this study, tDCS appears to be safe

  5. Development of Behavioral Indicators of Competences for Safety Culture of Nuclear Power Plants: A Preliminary Study

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Kwangsu; Kim, Sa Kil; Oh, Yeon Ju; Shin, Youmin; Lee, Yong-Hee; Jang, Tong Il [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    The term of safety competency in nuclear field was presented in the OECD/NEA workshop held in 1999. A model of the safety culture competencies in nuclear power plants was developed by KAERI (Korea Atomic Energy Research Institute). In general, a competency (competence) is defined as 'cluster of employee's attribute, knowledge, skill, ability or other characteristic that contributes to successful job performance'. We also defined safety culture competency as 'cluster of various internal characteristics (e.g., knowledge, skill, ability, motive, attitude and etc.) of employee that contribute to perform job safely and shape a healthy and strong safety culture.' By this definition, the safety culture competency is the broader construct including job competency. An employee having high level of safety culture competency shows extra discretionary effort to improve safety of peer, team and organization in addition to the individual's successful and safe job accomplishment. The behavioral indicators for each of the competencies are focal points of conversations on progress and are monitored continuously by self-assessment and managers or supervisors' intervention. Deficiencies in any of these indicators can point to coaching, training or other learning opportunities that employees may be required in order to improve. The purpose of this study was to derive a model of safety competencies for improving safety culture of NPPs and develop a set of behavioral indicators of each competency. In addition, the method of measuring behavioral indicators was suggested. For the application of developed safety culture competences and behavioral indicators, the most suitable measuring method for behavioral indicators must be developed. In the case of behavioral observations, behavioral dimensions (frequency, persistence and latency), observation possibility, occurrence basis of behavior (daily job performance, situational dependent) are considered to

  6. Preliminary safety analysis methodology for the SMART

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Kyoo Hwan; Chung, Y. J.; Kim, H. C.; Sim, S. K.; Lee, W. J.; Chung, B. D.; Song, J. H. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-03-01

    This technical report was prepared for a preliminary safety analysis methodology of the 330MWt SMART (System-integrated Modular Advanced ReacTor) which has been developed by Korea Atomic Energy Research Institute (KAERI) and funded by the Ministry of Science and Technology (MOST) since July 1996. This preliminary safety analysis methodology has been used to identify an envelope for the safety of the SMART conceptual design. As the SMART design evolves, further validated final safety analysis methodology will be developed. Current licensing safety analysis methodology of the Westinghouse and KSNPP PWRs operating and under development in Korea as well as the Russian licensing safety analysis methodology for the integral reactors have been reviewed and compared to develop the preliminary SMART safety analysis methodology. SMART design characteristics and safety systems have been reviewed against licensing practices of the PWRs operating or KNGR (Korean Next Generation Reactor) under construction in Korea. Detailed safety analysis methodology has been developed for the potential SMART limiting events of main steam line break, main feedwater pipe break, loss of reactor coolant flow, CEA withdrawal, primary to secondary pipe break and the small break loss of coolant accident. SMART preliminary safety analysis methodology will be further developed and validated in parallel with the safety analysis codes as the SMART design further evolves. Validated safety analysis methodology will be submitted to MOST as a Topical Report for a review of the SMART licensing safety analysis methodology. Thus, it is recommended for the nuclear regulatory authority to establish regulatory guides and criteria for the integral reactor. 22 refs., 18 figs., 16 tabs. (Author)

  7. Human studies on abecarnil a new beta-carboline anxiolytic: safety, tolerability and preliminary pharmacological profile.

    Science.gov (United States)

    Duka, T; Schütt, B; Krause, W; Dorow, R; McDonald, S; Fichte, K

    1993-04-01

    1. Abecarnil (isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate), a beta-carboline with high affinity for benzodiazepine receptors, was tested in healthy male subjects; single doses of abecarnil were given in five dosage levels (1 mg, 5 mg, 10 mg, 20 mg, 40 mg) and in a multiple dose study in four dosage levels (15 mg, 30 mg, 60 mg, 90 mg day-1) for 7 days. On two days following multiple dose treatment, placebo was given in single-blind conditions (follow-up). In each dosage level, in both studies drug was given to 10 subjects (7: verum, 3: placebo). 2. Safety and tolerability were evaluated by changes in vital signs, incidence and severity of adverse reactions and biochemical and haematological screening. Drug effects were estimated utilizing a bipolar visual analogue scale (poles: 'sleepy'-'alert') and a psychomotor task, the digit symbol substitution task. The pharmacokinetics of single and multiple doses were also determined in the multiple dose study. 3. Abecarnil was generally well tolerated. In the single dose study the most frequently reported side effects associated with abecarnil at high doses (20 and 40 mg) were dizziness, unsteady gait, and lack of concentration. A decrement in performance on the digit symbol substitution task was also observed in the two high dosage groups 20 mg and 40 mg. Evaluation of visual analogue scale ratings did not reveal a sedative effect even at higher doses. 4. In the multiple dose study the most frequently reported side effects during the treatment period were dizziness, unsteady gait, and lack of concentration.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia

    Directory of Open Access Journals (Sweden)

    F. Noël

    Full Text Available This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound comprised the evaluation of its in vitro properties, including plasma, microsomal and hepatocytes stability, cytochrome P450 metabolism and inhibition, plasma protein binding, and permeability using MDCK-MDR1 cells. De-risking and preliminary safety pharmacology assays were performed through screening of 44 off-target receptors and in vivo tests in mice (rota-rod and single dose toxicity. LDT5 is stable in rat and human plasma, human liver microsomes and hepatocytes, but unstable in rat liver microsomes and hepatocytes (half-life of 11 min. LDT5 is highly permeable across the MDCK-MDR1 monolayer (Papp ∼32×10-6 cm/s, indicating good intestinal absorption and putative brain penetration. LDT5 is not extensively protein-bound and is a substrate of human CYP2D6 and CYP2C19 but not of CYP3A4 (half-life >60 min, and did not significantly influence the activities of any of the human cytochrome P450 isoforms screened. LDT5 was considered safe albeit new studies are necessary to rule out putative central adverse effects through D2, 5-HT1A and 5-HT2B receptors, after chronic use. This work highlights the drug-likeness properties of LDT5 and supports its further preclinical development.

  9. Safety of modified Stoppa approach for Ganz periacetabular osteotomy: A preliminary cadaveric study.

    Science.gov (United States)

    Elmadağ, Mehmet; Uzer, Gökçer; Yıldız, Fatih; Ceylan, Hasan H; Acar, Mehmet A

    2016-08-01

    The aim of this cadaveric study was to investigate the efficacy of the modified Stoppa approach in Ganz periacetabular osteotomy (PAO). The Ganz PAO was performed on 10 hemipelvises with normal hips, from 5 cadavers using the modified Stoppa approach through the Pfannenstiel incision. All of the osteotomies were performed under fluoroscopic control and direct visualizing the osteotomy site from the same incision. After the osteotomy, the acetabulum was medialized and redirected anterolaterally, and fixed with 2 screws. The neurovascular structures and the joints were examined by dissecting the soft tissues after fixation of the osteotomies. Outcome parameters were center-edge (CE) angle, the distances between the osteotomy and anterior superior iliac spine (ASIS), and between the osteotomy and the sciatic notch, neurovascular and joint penetrations. After the osteotomy, the mean CE angle was improved from 19.8° to 25.2°, mean distance between the osteotomy and ASIS was 3.1 cm, and the mean distance between the osteotomy and the sciatic notch was 10.2 mm. The neurovascular structures and the joints were examined by dissecting the soft tissues after fixation of the osteotomies. No damage to the joint, surrounding arteries, veins or nerves was detected in any of the cadavers. Bilateral dysplastic hips can be treated with a 10 cm, cosmetically more acceptable incision in the same session using this approach. Quadrilateral surface of the acetabulum can be directly seen using this approach and the osteotomy can be safely performed. Copyright © 2016 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.

  10. Preliminary Conceptual Design for Safety Parameter display System of PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Hyunju; Seong, Seunghwan; Kim, Wansu; Kim, Donghoon; Son, Kwangseop; Jang, Gwisook [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    A PGSFR (prototype Gen-IV sodium-cooled fast reactor) is under development at KAERI. A safety parameter display system (SPDS) should be designed for licensing the PGSFR in order to cope with the TMI action plan requirements. Thus, a preliminary conceptual design for the SPDS of PGSFR including licensing requirements, intrinsic function, critical variables and alarm legs for the SPDS of the PGSFR is studied herein. At first, some documents issued by NRC related to install a SPDS include the following: - NUREG-0737, Clarification of TMI Action Plan Requirements - NUREG-0696, Functional Criteria for Emergency Response Facilities - NUREG-0835, Human Factors Acceptance Criteria for the Safety Parameter display System, Draft Report for Comment. The preliminary concept design for the SPDS of the PGSFR was studied. In designing of the PGSFR, the studied design concept will be refined and implemented through further studies to acquire the approval of a safety analysis report of the PGSFR.

  11. Preliminary study showing safety/efficacy of nanoss bioactive versus vitoss as bone graft expanders for lumbar noninstrumented fusions

    Directory of Open Access Journals (Sweden)

    Nancy E Epstein

    2015-01-01

    Conclusion: In this preliminary study of patients undergoing multilevel lumbar lamienctomies with posterolateral noninstrumented fusions, results were nearly comparable utilizing Vitoss or NanOss as bone graft expanders. Although the number of NanOss patients was substantially lower, the comparable efficacy and absence of postoperative complications for noninstrumented fusions is promising.

  12. Preliminary safety design analysis of KALIMER

    Energy Technology Data Exchange (ETDEWEB)

    Suk, Soo Dong; Kwon, Y. M.; Kim, K. D. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-03-01

    The national long-term R and D program updated in 1997 requires Korea Atomic Energy Research Institute(KAERI) to complete by the year 2006 the basic design of Korea Advanced Liquid Metal Reactor (KALIMER), along with supporting R and D work, with the capability of resolving the issue of spent fuel storage as well as with significantly enhanced safety. KALIMER is a 150 MWe pool-type sodium cooled prototype reactor that uses metallic fuel. The conceptual design is currently under way to establish a self consistent design meeting a set of the major safety design requirements for accident prevention. Some of current emphasis include those for inherent and passive means of negative reactivity insertion and decay heat removal, high shutdown reliability, prevention of and protection from sodium chemical reaction, and high seismic margin, among others. All of these requirements affect the reactor design significantly and involve supporting R and D programs of substance. This document first introduces a set of safety design requirements and accident evaluation criteria established for the conceptual design of KALIMER and then summarizes some of the preliminary results of engineering and design analyses performed for the safety of KALIMER. 19 refs., 19 figs., 6 tabs. (Author)

  13. Preliminary Study for Application of the New Safety Goal related with the Limitation of Cs-137 release

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Mi Ro; Shin, Tae Young [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    In the New Safety Goal, it is clearly stated that the Probabilistic Safety Assessment (PSA) should be performed with the proper technical appropriateness, the detail, and the scope in accordance with the integrated risk assessment against the accident for the nuclear power plants. This requirement is known to be come from the provision for preventing the long term ground contamination due to the release of radioactive material. However, there were so many concerns that this goal is so severe that the current design, even in the case of the constructing nuclear power plants, cannot meet this criterion. Especially for the operating nuclear power plants, since there were no mitigation facilities against the severe accident at the design stages, the application of this new goal is known to be much severe that the constructing nuclear power plants and it is necessary to develop the alternative methods to strengthen the safety of the operating nuclear power plants. The purpose of this study is to review the new safety goal from the view point of severe accident analysis and probabilistic safety assessment, and to find the appropriate methods in order to meet that goal for the operating nuclear power plants. In order to strengthen the safety for domestic nuclear power plants, all of the domestic operating nuclear power plants are required to prepare the Accident Management Plan within 3 years. Also, this Accident Management Plan should meet the New Safety Goal including the requirement that the sum of the accident frequency that the release of the radioactive nuclide Cs- 137 to the environment exceeds the 100TBq should be less than 1.0E-6/RY. Since the operating nuclear power plants was not designed against the severe accident and they have the limited exclusive mitigation facilities, it is not easy to meet the New Safety Goal. So, it is necessary to develop the alternative methods to meet the New Safety Goal. In this study, the amount of Cs-137 released to the

  14. Safety and preliminary efficacy of one month glycoprotein IIb/IIIa inhibition with lefradafiban in patients with acute coronary syndromes without ST-elevation; a phase II study.

    NARCIS (Netherlands)

    K.M. Akkerhuis (Martijn); K.L. Neuhaus (Karl); R.G. Wilcox (Robert); A. Vahanian (Alec); J-L. Boland (Jean); J. Hoffmann; T. Baardman (Taco); G. Nehmiz; U. Roth; A.P.J. Klootwijk (Peter); J.W. Deckers (Jaap); M.L. Simoons (Maarten)

    2000-01-01

    textabstractAIMS: Oral glycoprotein IIb/IIIa inhibitors might enhance the early benefit of an intravenous agent and prevent subsequent cardiac events in patients with acute coronary syndromes. We assessed the safety and preliminary efficacy of 1 month treatment with three dose levels of the oral GP

  15. A Preliminary Study on the Measures to Assess the Organizational Safety: The Cultural Impact on Human Error Potential

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Lee, Yong Hee [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2011-10-15

    The Fukushima I nuclear accident following the Tohoku earthquake and tsunami on 11 March 2011 occurred after twelve years had passed since the JCO accident which was caused as a result of an error made by JCO employees. These accidents, along with the Chernobyl accident, associated with characteristic problems of various organizations caused severe social and economic disruptions and have had significant environmental and health impact. The cultural problems with human errors occur for various reasons, and different actions are needed to prevent different errors. Unfortunately, much of the research on organization and human error has shown widely various or different results which call for different approaches. In other words, we have to find more practical solutions from various researches for nuclear safety and lead a systematic approach to organizational deficiency causing human error. This paper reviews Hofstede's criteria, IAEA safety culture, safety areas of periodic safety review (PSR), teamwork and performance, and an evaluation of HANARO safety culture to verify the measures used to assess the organizational safety

  16. A preliminary study of patients' perceptions on the implementation of the WHO surgical safety checklist in women who had Cesarean sections.

    Science.gov (United States)

    Kawano, Takashi; Tani, Megumi; Taniwaki, Miki; Ogata, Kimiyo; Yokoyama, Masataka

    2015-06-01

    The surgical safety checklist (SSCL), developed by the World Health Organization, is widely implemented by surgical staff for the improvement of their communication, teamwork, and safety culture in the operating room. However, there is no research available addressing the question of how surgical patients perceive the implementation of the SSCL. In order to address this issue, a questionnaire-based preliminary study was conducted for patients who had undergone elective Cesarean section under awake regional anesthesia. Although most participants had not been informed about the implementation of the SSCL before surgery, all of the patients were aware that the SSCL had been performed in the operating room. Over 80% of patients answered that the implementation of the SSCL could help to reduce their feelings of anxiety, tension, and fear, as well as enhance their feeling of security. Furthermore, most patients answered that they were able to understand the components as well as the purpose of the SSCL, and considered that the SSCL should be implemented. These results suggest that awake patients undergoing Cesarean section perceive the implementation of the SSCL to be a highly positive aspect of their surgical care.

  17. Study of Occupational Safety and Health Audit on Facilities at Ungku Omar College, Universiti Kebangsaan Malaysia (UKM): A Preliminary Analysis

    Science.gov (United States)

    Ariffin, Kadir; Ahmad, Shaharuddin; Aiyub, Kadaruddin; Awang, Azhan; Aziz, Azmi; Mohamad, Lukman Z.; Mamat, Samsu Adabi

    2010-01-01

    Occupational safety and health (OSH) in Universiti Kebangsaan Malaysia (UKM) is being considered as an important program to measure employee and student welfare and well-being. During academic session, apart from attending lectures, laboratory works, tutorial and library search, majority of students spend most of their time in residential…

  18. Feasibility and Safety of a Powered Exoskeleton for Assisted Walking for Persons With Multiple Sclerosis: A Single-Group Preliminary Study.

    Science.gov (United States)

    Kozlowski, Allan J; Fabian, Michelle; Lad, Dipan; Delgado, Andrew D

    2017-07-01

    To examine the feasibility, safety, and secondary benefit potential of exoskeleton-assisted walking with one device for persons with multiple sclerosis (MS). Single-group longitudinal preliminary study with 8-week baseline, 8-week intervention, and 4-week follow-up. Outpatient MS clinic, tertiary care hospital. Participants (N=13; age range, 38-62y) were mostly women with Expanded Disability Status Scale scores ranging from 5.5 to 7.0. Exoskeleton-assisted walk training. Primary outcomes were accessibility (enrollment/screen pass), tolerability (completion/dropout), learnability (time to event for standing, walking, and sitting with little or no assistance), acceptability (satisfaction on the device subscale of the Quebec User Evaluation of Satisfaction with Assistive Technology version 2), and safety (event rates standardized to person-time exposure in the powered exoskeleton). Secondary outcomes were walking without the device (timed 25-foot walk test and 6-minute walk test distance), spasticity (Modified Ashworth Scale), and health-related quality of life (Patient-Reported Outcomes Measurement and Information System pain interference and Quality of Life in Neurological Conditions fatigue, sleep disturbance, depression, and positive affect and well-being). The device was accessible to 11 and tolerated by 5 participants. Learnability was moderate, with 5 to 15 sessions required to walk with minimal assistance. Safety was good; the highest adverse event rate was for skin issues at 151 per 1000 hours' exposure. Acceptability ranged from not very satisfied to very satisfied. Participants who walked routinely improved qualitatively on sitting, standing, or walking posture. Two participants improved and 2 worsened on ≥1 quality of life domain. The pattern of spasticity scores may indicate potential benefit. The device appeared feasible and safe for about a third of our sample, for whom routine exoskeleton-assisted walking may offer secondary benefits. Copyright

  19. Preliminary Integrated Safety Analysis Status Report

    Energy Technology Data Exchange (ETDEWEB)

    D. Gwyn

    2001-04-01

    This report provides the status of the potential Monitored Geologic Repository (MGR) Integrated Safety Analysis (EA) by identifying the initial work scope scheduled for completion during the ISA development period, the schedules associated with the tasks identified, safety analysis issues encountered, and a summary of accomplishments during the reporting period. This status covers the period from October 1, 2000 through March 30, 2001.

  20. Intraarterial reteplase and intravenous abciximab for treatment of acute ischemic stroke. A preliminary feasibility and safety study in a non-human primate model

    Energy Technology Data Exchange (ETDEWEB)

    Qureshi, Adnan I. [University of Medicine and Dentistry of New Jersey, Zeenat Qureshi Stroke Research Center, Newark, NJ (United States); Suri, M. Fareed K.; Ali, Zulfiqar; Ringer, Andrew J.; Boulos, Alan S.; Guterman, Lee R.; Hopkins, L. Nelson [State University of New York, Department of Neurosurgery, Buffalo, NY (United States); Nakada, Marian T. [Centocor Inc., Malvern, PA (United States); Alberico, Ronald A. [State University of New York, Department of Radiology, Neuroradiology and Head and Neck Imaging, Buffalo, New York (United States); Martin, Lisa B.E. [State University of New York, Department of Comparative Medicine and Laboratory Animals Facilities, Roswell Park Cancer Institute, Buffalo, NY (United States)

    2005-11-01

    We performed a preliminary feasibility and safety study using intravenous (IV) administration of a platelet glycoprotein IIb/IIIa inhibitor (abciximab) in conjunction with intraarterial (IA) administration of a thrombolytic agent (reteplase) in a primate model of intracranial thrombosis. We introduced thrombus through superselective catheterization of the intracranial segment of the internal carotid artery in 16 primates. The animals were randomly assigned to receive IA reteplase and IV abciximab (n =4), IA reteplase and IV placebo (n =4), IA placebo and IV abciximab (n =4) or IA and IV placebo (n =4). Recanalization was assessed by serial angiography during the 6-h period after initiation of treatment. Postmortem magnetic resonance (MR) imaging was performed to determine the presence of cerebral infarction or intracranial hemorrhage. Partial or complete recanalization at 6 h after initiation of treatment (decrease of two or more points in pre-treatment angiographic occlusion grade) was observed in two animals treated with IA reteplase and IV abciximab, three animals treated with IA reteplase alone and one animal treated with IV abciximab alone. No improvement in perfusion was observed in animals that received IV and IA placebo. Cerebral infarction was demonstrated on postmortem MR imaging in three animals that received IA and IV placebo and in one animal each from the groups that received IA reteplase and IV abciximab or IV abciximab alone. One animal that received IV abciximab alone had a small intracerebral hemorrhage on MR imaging. (orig.)

  1. Safety Study in Aviation

    Directory of Open Access Journals (Sweden)

    Marek Štumper

    2016-07-01

    Full Text Available The objective of this article is to provide a brief look at safety studies, which are a necessary part of every change of system or a new system in aviation. The main focus is put on the area of air traffic management, because it affects most of the aviation stakeholders. The article begins with a description of safety and safety assessment of changes in systems. Then it discusses analysis of processes, hazard identification and risk assessment. Main part focuses on Safety studies and briefly describes the elements of the study. At the end, possible ways of safety study evaluation are mentioned.

  2. Effectiveness and safety of Nintendo Wii Fit Plus™ training in children with migraine without aura: a preliminary study.

    Science.gov (United States)

    Esposito, Maria; Ruberto, Maria; Gimigliano, Francesca; Marotta, Rosa; Gallai, Beatrice; Parisi, Lucia; Lavano, Serena Marianna; Roccella, Michele; Carotenuto, Marco

    2013-01-01

    Migraine without aura (MoA) is a painful syndrome, particularly in childhood; it is often accompanied by severe impairments, including emotional dysfunction, absenteeism from school, and poor academic performance, as well as issues relating to poor cognitive function, sleep habits, and motor coordination. The study population consisted of 71 patients affected by MoA (32 females, 39 males) (mean age: 9.13±1.94 years); the control group consisted of 93 normally developing children (44 females, 49 males) (mean age: 8.97±2.03 years) recruited in the Campania school region. The entire population underwent a clinical evaluation to assess total intelligence quotient level, visual-motor integration (VMI) skills, and motor coordination performance, the later using the Movement Assessment Battery for Children (M-ABC). Children underwent training using the Wii-balance board and Nintendo Wii Fit Plus™ software (Nintendo Co, Ltd, Kyoto, Japan); training lasted for 12 weeks and consisted of three 30-minute sessions per week at their home. The two starting populations (MoA and controls) were not significantly different for age (P=0.899) and sex (P=0.611). M-ABC and VMI performances at baseline (T0) were significantly different in dexterity, balance, and total score for M-ABC (PVMI. After 3 months of Wii training (T1), MoA children showed a significant improvement in M-ABC global performance (PVMI motor task (P<0.001). Our study reported the positive effects of the Nintendo Wii Fit Plus™ system as a rehabilitative device for the visuomotor and balance skills impairments among children affected by MoA, even if further research and longer follow-up are needed.

  3. Effectiveness and safety of Nintendo Wii Fit PlusTM training in children with migraine without aura: a preliminary study

    Directory of Open Access Journals (Sweden)

    Esposito M

    2013-11-01

    Full Text Available Maria Esposito,1 Maria Ruberto,2 Francesca Gimigliano,1,2 Rosa Marotta,3 Beatrice Gallai,4 Lucia Parisi,5 Serena Marianna Lavano,3 Michele Roccella,5 Marco Carotenuto11Center for Childhood Headache, Child and Adolescent Neuropsychiatry Clinic, Department of Mental Health, Physical and Preventive Medicine, 2Department of Odonto-Stomathologic Disciplines, Pathology – Orthopedic Sciences, Second University of Naples, Naples, Italy; 3Department of Psychiatry, “Magna Graecia” University of Catanzaro, Catanzaro, Italy; 4Unit of Child and Adolescent Neuropsychiatry, University of Perugia, Perugia, Italy; 5Child Neuropsychiatry, Department of Psychology, University of Palermo, Palermo, ItalyBackground: Migraine without aura (MoA is a painful syndrome, particularly in childhood; it is often accompanied by severe impairments, including emotional dysfunction, absenteeism from school, and poor academic performance, as well as issues relating to poor cognitive function, sleep habits, and motor coordination.Materials and methods: The study population consisted of 71 patients affected by MoA (32 females, 39 males (mean age: 9.13±1.94 years; the control group consisted of 93 normally developing children (44 females, 49 males (mean age: 8.97±2.03 years recruited in the Campania school region. The entire population underwent a clinical evaluation to assess total intelligence quotient level, visual-motor integration (VMI skills, and motor coordination performance, the later using the Movement Assessment Battery for Children (M-ABC. Children underwent training using the Wii-balance board and Nintendo Wii Fit Plus™ software (Nintendo Co, Ltd, Kyoto, Japan; training lasted for 12 weeks and consisted of three 30-minute sessions per week at their home.Results: The two starting populations (MoA and controls were not significantly different for age (P=0.899 and sex (P=0.611. M-ABC and VMI performances at baseline (T0 were significantly different in dexterity

  4. Study on the KALIMER safety approach

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Eui Kwang; Han, Do Hee; Kim, Young Cheol

    1997-01-01

    This study describes KALIMER`s safety approach, how to establish the safety criteria and temperature limit, how to define safety evaluation events, and some safety research and development needs items. It is recommended that the KALIMER`s approach to safety use seven levels of safety design and a defense-in-depth design approach with particular emphasis on inherent passive features. In order to establish as set DBEs for KALIMER safety evaluation, the procedure is explained how to define safety evaluation events. Final selection is to be determined later with the final establishment of design concepts. On the basis of preliminary studies and evaluation of the plant safety related areas, the KALIMER and PRISM have following three main difference that may require special research and development for KALIMER. (author). 7 refs., 6 tabs., 6 figs.

  5. Safety Study in Aviation

    OpenAIRE

    2016-01-01

    The objective of this article is to provide a brief look at safety studies, which are a necessary part of every change of system or a new system in aviation. The main focus is put on the area of air traffic management, because it affects most of the aviation stakeholders. The article begins with a description of safety and safety assessment of changes in systems. Then it discusses analysis of processes, hazard identification and risk assessment. Main part focuses on Safety studies and briefly...

  6. Participatory design of a preliminary safety checklist for general practice.

    Science.gov (United States)

    Bowie, Paul; Ferguson, Julie; MacLeod, Marion; Kennedy, Susan; de Wet, Carl; McNab, Duncan; Kelly, Moya; McKay, John; Atkinson, Sarah

    2015-05-01

    The use of checklists to minimise errors is well established in high reliability, safety-critical industries. In health care there is growing interest in checklists to standardise checking processes and ensure task completion, and so provide further systemic defences against error and patient harm. However, in UK general practice there is limited experience of safety checklist use. To identify workplace hazards that impact on safety, health and wellbeing, and performance, and codesign a standardised checklist process. Application of mixed methods to identify system hazards in Scottish general practices and develop a safety checklist based on human factors design principles. A multiprofessional 'expert' group (n = 7) and experienced front-line GPs, nurses, and practice managers (n = 18) identified system hazards and developed and validated a preliminary checklist using a combination of literature review, documentation review, consensus building workshops using a mini-Delphi process, and completion of content validity index exercise. A prototype safety checklist was developed and validated consisting of six safety domains (for example, medicines management), 22 sub-categories (for example, emergency drug supplies) and 78 related items (for example, stock balancing, secure drug storage, and cold chain temperature recording). Hazards in the general practice work system were prioritised that can potentially impact on the safety, health and wellbeing of patients, GP team members, and practice performance, and a necessary safety checklist prototype was designed. However, checklist efficacy in improving safety processes and outcomes is dependent on user commitment, and support from leaders and promotional champions. Although further usability development and testing is necessary, the concept should be of interest in the UK and internationally. © British Journal of General Practice 2015.

  7. Preliminary Safety Evaluation of a New Bacteroides xylanisolvens Isolate

    Science.gov (United States)

    Toutounian, Kawe; Schmidt, Jens; Karsten, Uwe; Goletz, Steffen

    2012-01-01

    Besides conferring some health benefit to the host, a bacterial strain must present an unambiguous safety status to be considered a probiotic. We here present the preliminary safety evaluation of a new Bacteroides xylanisolvens strain (DSM 23964) isolated from human feces. First results suggest that it may be able to provide probiotic health benefits. Its identity was confirmed by biochemical analysis, by sequencing of its 16S rRNA genes, and by DNA-DNA hybridization. Virulence determinants known to occur in the genus Bacteroides, such the bft enterotoxin and other enzymatic activities involved in the degradation of the extracellular matrix and the capsular polysaccharide PS A, were absent in this strain. The investigation of the antibiotic susceptibility indicated that strain DSM 23964 was sensitive to metronidazole, meropenem agents, and clindamycin. Resistance to penicillin and ampicillin was identified to be conferred by the β-lactamase cepA gene and could therefore be restored by adding β-lactamase inhibitors. The localization of the cepA gene in the genome of strain DSM 23964 and the absence of detectable plasmids further suggest that a transfer of β-lactamase activity or the acquisition of other antibiotic resistances are highly improbable. Taken together, the presented data indicate that the strain B. xylanisolvens DSM 23964 has no virulence potential. Since it also resists the action of gastric enzymes and low-pH conditions, this strain is an interesting candidate for further investigation of its safety and potential health-promoting properties. PMID:22101046

  8. Preliminary safety evaluation for the plutonium stabilization and packaging system

    Energy Technology Data Exchange (ETDEWEB)

    Shapley, J.E., Fluor Daniel Hanford

    1997-03-14

    This Preliminary Safety Evaluation (PSE) describes and analyzes the installation and operation of the Plutonium Stabilization and Packaging System (SPS) at the Plutonium Finishing Plant (PFP). The SPS is a combination of components required to expedite the safe and timely storage of Plutonium (Pu) oxide. The SPS program will receive site Pu packages, process the Pu for storage, package the Pu into metallic containers, and safely store the containers in a specially modified storage vault. The location of the SPS will be in the 2736- ZB building and the storage vaults will be in the 2736-Z building of the PFP, as shown in Figure 1-1. The SPS will produce storage canisters that are larger than those currently used for Pu storage at the PFP. Therefore, the existing storage areas within the PFP secure vaults will require modification. Other modifications will be performed on the 2736-ZB building complex to facilitate the installation and operation of the SPS.

  9. Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism.

    Science.gov (United States)

    Whiting, Donald M; Tomycz, Nestor D; Bailes, Julian; de Jonge, Lilian; Lecoultre, Virgile; Wilent, Bryan; Alcindor, Dunbar; Prostko, E Richard; Cheng, Boyle C; Angle, Cynthia; Cantella, Diane; Whiting, Benjamin B; Mizes, J Scott; Finnis, Kirk W; Ravussin, Eric; Oh, Michael Y

    2013-07-01

    Deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) has been suggested as a potential treatment for intractable obesity. The authors present the 2-year safety results as well as early efficacy and metabolic effects in 3 patients undergoing bilateral LHA DBS in the first study of this approach in humans. Three patients meeting strict criteria for intractable obesity, including failed bariatric surgery, underwent bilateral implantation of LHA DBS electrodes as part of an institutional review board- and FDA-approved pilot study. The primary focus of the study was safety; however, the authors also received approval to collect data on early efficacy including weight change and energy metabolism. No serious adverse effects, including detrimental psychological consequences, were observed with continuous LHA DBS after a mean follow-up of 35 months (range 30-39 months). Three-dimensional nonlinear transformation of postoperative imaging superimposed onto brain atlas anatomy was used to confirm and study DBS contact proximity to the LHA. No significant weight loss trends were seen when DBS was programmed using standard settings derived from movement disorder DBS surgery. However, promising weight loss trends have been observed when monopolar DBS stimulation has been applied via specific contacts found to increase the resting metabolic rate measured in a respiratory chamber. Deep brain stimulation of the LHA may be applied safely to humans with intractable obesity. Early evidence for some weight loss under metabolically optimized settings provides the first "proof of principle" for this novel antiobesity strategy. A larger follow-up study focused on efficacy along with a more rigorous metabolic analysis is planned to further explore the benefits and therapeutic mechanism behind this investigational therapy.

  10. HACCP and water safety plans in Icelandic water supply: preliminary evaluation of experience.

    Science.gov (United States)

    Gunnarsdóttir, María J; Gissurarson, Loftur R

    2008-09-01

    Icelandic waterworks first began implementing hazard analysis and critical control points (HACCP) as a preventive approach for water safety management in 1997. Since then implementation has been ongoing and currently about 68% of the Icelandic population enjoy drinking water from waterworks with a water safety plan based on HACCP. Preliminary evaluation of the success of HACCP implementation was undertaken in association with some of the waterworks that had implemented HACCP. The evaluation revealed that compliance with drinking water quality standards improved considerably following the implementation of HACCP. In response to their findings, waterworks implemented a large number of corrective actions to improve water safety. The study revealed some limitations for some, but not all, waterworks in relation to inadequate external and internal auditing and a lack of oversight by health authorities. Future studies should entail a more comprehensive study of the experience with the use of HACCP with the purpose of developing tools to promote continuing success.

  11. Muhammadiyah: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Azyumardi Azra

    2014-03-01

    Full Text Available This article is a collection of Bibliography reviewer that discuss Muhammadiyah. The following are some of the bibliography were reviewed:A.R. Sukrianta dan Abdul Munir Malkhan, Perkembangan Pemikiran Muhammadiyah dari Masa ke Masa: Menyambut Muktamar ke-41, (Yogyakarta: Dua Dimensi, 1985.A.R. Sukriyanto dan Abdul Munir Mulkhan, Pergumulan Pemikiran dalam Muhammadiyah, (Yogyakarta: Sipress, 1990.Ruslan Abdul Gani. et.al., Cita dan Citra Muhammadiyah, (Jakarta: Pustaka Panjimas, 1985.M.T. Arifin, Gagasan Pembaharuan Muhammadiyah, (Jakarta: Pustaka Jaya, 1987.M.T. Arifin, Muhammadiyah: Potret yang Berubah, (Surakarta: Institut Gelanggang Pemikiran Filsafat Sosial Budaya dan Kependidikan, 1990.M. Yusron Asrofie, Kiyai Haji Ahmad Dahlan, Pemikiran dan Kepemimpinannya, (Yogyakarta: Yogyakarta Offset, 1983.Fathurrahman Djamil, Ijtihad Muhammadiyah dalam Masalah-masalah Fiqh Kontemporer, (Jakarta: Doctoral Dissertation the State Institute of Islamic Studies (IAIN, 1994.Yunahar Ilyas. et.al., Muhammadiyah dan NU: Reorientasi Wawasan Keislaman, (Yogyakarta: LPPI UMY, LKPSM NU, & PP al-Muhsin, 1993.Musthafa kamal, Chusnan Yusuf, dan Rosyad Sholeh, Muhammadiyah sebagai Gerakan Islam, (Yogyakarta: Penerbit Persatuan, 1976.M. Rusli Karim, Muhammadiyah dalam Kritik dan Komentar, (Jakarta: Rajawali, 1986.Arbiyah Lubis, Pemikiran Muhammadiyah dan Muhammad Abduh: Suatu Studi Perbandingan, (Jakarta: Doctoral Dissertation the State Institute of Islamic Studies (IAIN, 1989.Abdul Munir Mulkhan, Pemikiran K.H. Ahmad Dahlan dan Muhammadiyah dalam Perspektif Perubahan Sosial, (Jakarta: Bumi Aksara, 1990.Abdul Munir Mulkhan, Pak AR Menjawab 245 Permasalahan dalam Islam, (Yogyakarta: Sipress, 1990.M. Din Syamsuddin, Muhammadiyah Kini dan Esok, (Jakarta: Pustaka Panjimas, 1990.H.S. Prodjokusumo, Melestarikan Muhammadiyah, (Jakarta: Pimpinan Pusat Muhammadiyah, 1985.Yusuf Abdullah Puar, Perjuangan dan Pengabdian Muhammadiyah, (Jakarta: Pustaka Antara, 1989.Sahlan Rosidi

  12. Mapping the nomological network of employee self-determined safety motivation: A preliminary measure in China.

    Science.gov (United States)

    Jiang, Li; Tetrick, Lois E

    2016-09-01

    The present study introduced a preliminary measure of employee safety motivation based on the definition of self-determination theory from Fleming (2012) research and validated the structure of self-determined safety motivation (SDSM) by surveying 375 employees in a Chinese high-risk organization. First, confirmatory factor analysis (CFA) was used to examine the factor structure of SDSM, and indices of five-factor model CFA met the requirements. Second, a nomological network was examined to provide evidence of the construct validity of SDSM. Beyond construct validity, the analysis also produced some interesting results concerning the relationship between leadership antecedents and safety motivation, and between safety motivation and safety behavior. Autonomous motivation was positively related to transformational leadership, negatively related to abusive supervision, and positively related to safety behavior. Controlled motivation with the exception of introjected regulation was negatively related to transformational leadership, positively related to abusive supervision, and negatively related to safety behavior. The unique role of introjected regulation and future research based on self-determination theory were discussed.

  13. Conversion Preliminary Safety Analysis Report for the NIST Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, D. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Baek, J. S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hanson, A. L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cheng, L-Y [Brookhaven National Lab. (BNL), Upton, NY (United States); Brown, N. [Brookhaven National Lab. (BNL), Upton, NY (United States); Cuadra, A. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-01-30

    The NIST Center for Neutron Research (NCNR) is a reactor-laboratory complex providing the National Institute of Standards and Technology (NIST) and the nation with a world-class facility for the performance of neutron-based research. The heart of this facility is the NIST research reactor (aka NBSR); a heavy water moderated and cooled reactor operating at 20 MW. It is fueled with high-enriched uranium (HEU) fuel elements. A Global Threat Reduction Initiative (GTRI) program is underway to convert the reactor to low-enriched uranium (LEU) fuel. This program includes the qualification of the proposed fuel, uranium and molybdenum alloy foil clad in an aluminum alloy, and the development of the fabrication techniques. This report is a preliminary version of the Safety Analysis Report (SAR) that would be submitted to the U.S. Nuclear Regulatory Commission (NRC) for approval prior to conversion. The report follows the recommended format and content from the NRC codified in NUREG-1537, “Guidelines for Preparing and Reviewing Applications for the Licensing of Non-power Reactors,” Chapter 18, “Highly Enriched to Low-Enriched Uranium Conversions.” The emphasis in any conversion SAR is to explain the differences between the LEU and HEU cores and to show the acceptability of the new design; there is no need to repeat information regarding the current reactor that will not change upon conversion. Hence, as seen in the report, the bulk of the SAR is devoted to Chapter 4, Reactor Description, and Chapter 13, Safety Analysis.

  14. Safety and Efficacy Studies of Vertebroplasty, Kyphoplasty, and Mesh-Container-Plasty for the Treatment of Vertebral Compression Fractures: Preliminary Report.

    Science.gov (United States)

    Chen, Chen; Li, Donghua; Wang, Zhiguo; Li, Tong; Liu, Xunwei; Zhong, Jian

    2016-01-01

    To evaluate the clinical safety and efficacies of percutaneous vertebroplasty (PVP), percutaneous kyphoplasty (PKP), and percutaneous mesh-container-plasty (PMCP) for the treatment of vertebral compression fractures (VCFs), a retrospective study of 90 patients with VCFs who had been treated by PVP (n = 30), PKP (n = 30), and PMCP (n = 30) was conducted. The clinical efficacies of these three treatments were evaluated by comparing their PMMA cement leakages, cement patterns, height restoration percentages, wedge angles, visual analogue scales (VAS), and oswestry disability index (ODI) at the pre- and post-operative time points. 6.67%, 3.33%, and 0% of patients had PMMA leakage in PVP, PKP, and PMCP groups, respectively. Three (solid, trabecular, and mixed patterns), two (solid and mixed patterns), and one (mixed patterns) types of cement patterns were observed in PVP, PKP, and PMCP groups, respectively. PKP and PMCP treatments had better height restoration ability than PVP treatment. PVP, PKP, and PMCP treatments had significant and similar ability in pain relief and functional recovery ability for the treatment of VCFs. These results indicate minimally invasive techniques were effective methods for the treatment of VCFs. Moreover, these initial outcomes suggest PMCP treatment may be better than both PVP treatment and PKP treatment.

  15. Safety and Efficacy Studies of Vertebroplasty, Kyphoplasty, and Mesh-Container-Plasty for the Treatment of Vertebral Compression Fractures: Preliminary Report

    Science.gov (United States)

    Chen, Chen; Li, Donghua; Wang, Zhiguo; Li, Tong; Liu, Xunwei; Zhong, Jian

    2016-01-01

    To evaluate the clinical safety and efficacies of percutaneous vertebroplasty (PVP), percutaneous kyphoplasty (PKP), and percutaneous mesh-container-plasty (PMCP) for the treatment of vertebral compression fractures (VCFs), a retrospective study of 90 patients with VCFs who had been treated by PVP (n = 30), PKP (n = 30), and PMCP (n = 30) was conducted. The clinical efficacies of these three treatments were evaluated by comparing their PMMA cement leakages, cement patterns, height restoration percentages, wedge angles, visual analogue scales (VAS), and oswestry disability index (ODI) at the pre- and post-operative time points. 6.67%, 3.33%, and 0% of patients had PMMA leakage in PVP, PKP, and PMCP groups, respectively. Three (solid, trabecular, and mixed patterns), two (solid and mixed patterns), and one (mixed patterns) types of cement patterns were observed in PVP, PKP, and PMCP groups, respectively. PKP and PMCP treatments had better height restoration ability than PVP treatment. PVP, PKP, and PMCP treatments had significant and similar ability in pain relief and functional recovery ability for the treatment of VCFs. These results indicate minimally invasive techniques were effective methods for the treatment of VCFs. Moreover, these initial outcomes suggest PMCP treatment may be better than both PVP treatment and PKP treatment. PMID:26963808

  16. Safety and Efficacy Studies of Vertebroplasty, Kyphoplasty, and Mesh-Container-Plasty for the Treatment of Vertebral Compression Fractures: Preliminary Report.

    Directory of Open Access Journals (Sweden)

    Chen Chen

    Full Text Available To evaluate the clinical safety and efficacies of percutaneous vertebroplasty (PVP, percutaneous kyphoplasty (PKP, and percutaneous mesh-container-plasty (PMCP for the treatment of vertebral compression fractures (VCFs, a retrospective study of 90 patients with VCFs who had been treated by PVP (n = 30, PKP (n = 30, and PMCP (n = 30 was conducted. The clinical efficacies of these three treatments were evaluated by comparing their PMMA cement leakages, cement patterns, height restoration percentages, wedge angles, visual analogue scales (VAS, and oswestry disability index (ODI at the pre- and post-operative time points. 6.67%, 3.33%, and 0% of patients had PMMA leakage in PVP, PKP, and PMCP groups, respectively. Three (solid, trabecular, and mixed patterns, two (solid and mixed patterns, and one (mixed patterns types of cement patterns were observed in PVP, PKP, and PMCP groups, respectively. PKP and PMCP treatments had better height restoration ability than PVP treatment. PVP, PKP, and PMCP treatments had significant and similar ability in pain relief and functional recovery ability for the treatment of VCFs. These results indicate minimally invasive techniques were effective methods for the treatment of VCFs. Moreover, these initial outcomes suggest PMCP treatment may be better than both PVP treatment and PKP treatment.

  17. A Preliminary Report on the CO2 Laser for Lumbar Fusion: Safety, Efficacy and Technical Considerations.

    Science.gov (United States)

    Villavicencio, Alan T; Burneikiene, Sigita; Babuska, Jason M; Nelson, Ewell L; Mason, Alexander; Rajpal, Sharad

    2015-04-01

    The purpose of this study was to evaluate potential technical advantages of the CO2 laser technology in mini-open transforaminal lumbar interbody fusion (TLIF) surgeries and report our preliminary clinical data on the safety and clinical outcomes. There is currently no literature discussing the recently redeveloped CO2 laser technology application for lumbar fusion. Safety and clinical outcomes were compared between two groups: 24 patients that underwent CO2 laser-assisted one-level TLIF surgeries and 30 patients that underwent standard one-level TLIF surgeries without the laser. There were no neural thermal injuries or other intraoperative laser-related complications encountered in this cohort of patients. At a mean follow-up of 17.4 months, significantly reduced lower back pain scores (P=0.013) were reported in the laser-assisted patient group compared to a standard fusion patient group. Lower extremity radicular pain intensity scores were similar in both groups. Laser-assisted TLIF surgeries showed a tendency (P = 0.07) of shorter operative times that was not statistically significant. Based on this preliminary clinical report, the safety of the CO2 laser device for lumbar fusion surgeries was assessed. There were no neural thermal injuries or other intraoperative laser-related complications encountered in this cohort of patients. Further investigation of CO2 laser-assisted lumbar fusion procedures is warranted in order to evaluate its effect on clinical outcomes.

  18. Preliminary Study on Public Participation in Food Safety Monitoring of China%我国食品安全监管中的公众参与研究

    Institute of Scientific and Technical Information of China (English)

    尹春; 唐晓纯

    2013-01-01

    Public participation in food safety has become one of the hot issues among experts in recent years.Firstly,we discussed the concept and significance of food safety monitoring system in China.Secondly,we made in-depth analysis on the problems such as the lack of effective monitoring mechanism in public participation,high cost in protecting people,s rights,the defective punishment system and information disclosure system.Thirdly,we analyzed foreign experience of public participation in food safety monitoring.Finally,we gave our opinions and suggestions to improve the situation.%近年来,食品安全公众参与成为学者讨论的热门话题.文章就我国食品安全监管中公众参与的概念和意义进行了探讨,并深入分析我国食品安全监管中公众参与缺乏有效的反馈机制、公民维权成本高、政府惩罚力度和信息公开力度不够等问题,对此借鉴国外食品安全监管公众参与的经验,对我国食品安全公众参与提出了相关意见和建议.

  19. Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study

    Directory of Open Access Journals (Sweden)

    Karin Neukam

    2014-11-01

    Full Text Available Introduction: Although hepatotoxicity related to antiretroviral treatment (ART has become less frequent, hepatotoxic events, such as transaminase elevations (TE, are still a matter of concern. RPV/FTC/TDF (EPA is a new single tablet regimen which is widely used in real life practice. Clinical trials showed an adequate profile of liver safety in the sub-population of HIV/HCV-coinfected patients receiving rilpivirine. However, the number of individuals included in these analyses is low (1. The aim of this ongoing study is to evaluate the incidence of TE and total bilirubin elevations (TBE during the first 48 weeks of EPA-based therapy in a large population of HIV/HCV-coinfected subjects outside of clinical trials. Patients and Methods: This is a retrospective analysis of HIV/HCV-coinfected subjects who started EPA at the infectious diseases units of 14 centres throughout Spain, included as cases. Subjects who started an ART different to EPA during the study period at the same hospitals were selected as controls. The primary outcome variables were grade 3 or 4 TE and grade 4 TBE. Results: Of the 191 patients included, 31 (16.2% subjects were naïve to ART. Eighty-seven individuals started EPA and the remaining ones were controls. The most common NRTI backbone among the controls was TDF/FTC [59 (56.7% patients] followed by NRTI-sparing regimens [24 (23.1% individuals] and ABC/3TC [17 (16.3% subjects]. Among controls, 67 (64.4% started a ritonavir-boosted protease inhibitor, mainly DRV/r [41 (39.4% patients] followed by ATV/r [16 (15.4% subjects]. EFV, ETV and RAL were started in 16 (15.4%, 12 (11.5% and 13 (12.5% subjects, respectively. The median (Q1–Q3 follow-up was 5.79 (3.65–8.61 months for the cases and 11.44 (5.8–12.88 months for the controls. TE was observed in two (2.3% cases versus five (4.8% controls (p=0.358, accounting for a density of incidence of 4.32/100 person-years versus 5.51/100 person-years [incidence rate difference (95

  20. Studies relating to human intrusion into a repository. Report pertaining to work package 11. Preliminary safety case of the Gorleben site (VSG)

    Energy Technology Data Exchange (ETDEWEB)

    Beuth, Thomas; Buhmann, Dieter; Fischer-Appelt, Klaus; Moenig, Joerg; Ruebel, Andre; Wolf, Jens [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Koeln (Germany); Bollingerfehr, Wilhelm; Filbert, Wolfgang [DBE Technology GmbH, Peine (Germany); Charlier, Frank [international nuclear safety engineering gmbh (nse), Aachen (Germany); Baltes, Bruno

    2014-10-15

    The question of the long-term safety of a repository system is inseparably linked with the intensive technical examination of the possible future evolution of the site and the repository system e. g. as a result of climatic, geologic, waste-related and repository-related processes. Here, the possible evolutions to be considered are those that have the potential to have a negative impact on the intended, furthest-possible, immediate, and lasting isolation of the radioactive waste in a defined area around the underground workings of the repository mine in salt rock, which is referred to as the containment-providing rock zone (CPRZ).

  1. 液态熔盐堆运行安全特性初步研究%Preliminary Study on Safety Characteristics of Molten Salt Reactor

    Institute of Scientific and Technical Information of China (English)

    魏泉; 梅龙伟; 战志超; 郭威; 陈金根; 蔡翔舟

    2014-01-01

    Compared with solid fuel reactors ,there are differences in physics for liquid fuel reactor .As for molten salt reactor (MSR) ,due to fuel flow in primary loop ,the delayed neutron precursors and fission product partly decay out of core , resulting in reactivity loss as well as heat generation in the primary loop .In this paper ,the critical dynamics and safety characteristics of MSR were investigated using Cinsf 1D code .Con‐sidering the loss of delayed neutrons under different fuel flow speeds at zero‐power ,the corresponding control rod positions were calculated under pump start and stop condi‐tions .Keeping reactor power at 2 MW ,the temperature and power were computed for the primary loop system . Finally , the pump stop accident was simulated from rated power 2 MW . After pump stop , the reactor power increases slightly due to the reduction of delayed neutron loss at initial time and then it decreases to approach the decay heat power level quickly .The temperature in core increases slowly and reaches to a balance within safety range .It can be concluded that MSR has intrinsic safety .%液态燃料反应堆与固态燃料反应堆相比,原理上有较大不同。液态熔盐堆中由于燃料流动带走缓发中子先驱核在堆外衰变导致堆芯反应性降低,且裂变产物在堆外回路中衰变也会引起一回路发热。本文使用熔盐堆中子动力学程序Cinsf1D探讨2 M W熔盐堆的临界动力学特性和安全特性,研究零功率临界下不同熔盐流速启泵和停泵导致的缓发中子先驱核流失所需改变的控制棒棒位。同时还计算了2 MW恒定功率情况下稳态运行及降低流速时一回路温度分布,并模拟了2 MW额定功率下停泵事件。停泵后由于缓发中子损失减少反应堆功率先缓慢增加,然后迅速降低到接近余热水平。停泵后堆芯温度缓慢增加后稳定在安全值以内,说明熔盐堆具有本征安全性。

  2. Customer Relationship Management System in Occupational Safety & Health Companies: Research on Practice and Preliminary Design Solution

    Directory of Open Access Journals (Sweden)

    Robert Fabac

    2011-10-01

    Full Text Available One of the most prominent contemporary trends in formation of companies is the approach to development of a customer-oriented company. In this matter, various versions related to the intensity of this orientation are differentiated. Customer relationship management (CRM system is a well-known concept, and its practice is being studied and improved in connection to various sectors. Companies providing services of occupational safety and health (OHS mainly cooperate with a large number of customers and the quality of this cooperation largely affects the occupational safety and health of employees. Therefore, it is of both scientific and wider social interest to study and improve the relationship of these companies with their customers. This paper investigates the practice of applying CRM in Croatian OHS companies. It identifies the existing conditions and suggests possible improvements in the practice of CRM, based on experts’ assessments using analytic hierarchy process evaluation. Universal preliminary design was created as a framework concept for the formation of a typical customer-oriented OHS services company. Preliminary design includes a structural view, which provides more details through system diagrams, and an illustration of main cooperation processes of a company with its customer.

  3. Preliminary safety information document for the standard MHTGR. Volume 4

    Energy Technology Data Exchange (ETDEWEB)

    None

    1986-01-01

    This report contains information concerning: operational radionuclide control; occupational radiation protection, conduct of operations; initial test program; safety analysis; technical specifications; and quality assurance. (JDB)

  4. Chemical Safety Alert: Identifying Chemical Reactivity Hazards Preliminary Screening Method

    Science.gov (United States)

    Introduces small-to-medium-sized facilities to a method developed by Center for Chemical Process Safety (CCPS), based on a series of twelve yes-or-no questions to help determine hazards in warehousing, repackaging, blending, mixing, and processing.

  5. Preliminary safety evaluation of an aircraft impact on a near-surface radioactive waste repository

    Energy Technology Data Exchange (ETDEWEB)

    Lo Frano, R.; Forasassi, G.; Pugliese, G. [Department of Industrial and Civil Engineering (DICI), University of Pisa, Pisa (Italy)

    2013-07-01

    The aircraft impact accident has become very significant in the design of a nuclear facilities, particularly, after the tragic September 2001 event, that raised the public concern about the potential damaging effects that the impact of a large civilian airplane could bring in safety relevant structures. The aim of this study is therefore to preliminarily evaluate the global response and the structural effects induced by the impact of a military or commercial airplane (actually considered as a 'beyond design basis' event) into a near surface radioactive waste (RWs) disposal facility. The safety evaluation was carried out according to the International safety and design guidelines and in agreement with the stress tests requirements for the security track. To achieve the purpose, a lay out and a scheme of a possible near surface repository, like for example those of the El Cabril one, were taken into account. In order to preliminarily perform a reliable analysis of such a large-scale structure and to determine the structural effects induced by such a types of impulsive loads, a realistic, but still operable, numerical model with suitable materials characteristics was implemented by means of FEM codes. In the carried out structural analyses, the RWs repository was considered a 'robust' target, due to its thicker walls and main constitutive materials (steel and reinforced concrete). In addition to adequately represent the dynamic response of repository under crashing, relevant physical phenomena (i.e. penetration, spalling, etc.) were simulated and analysed. The preliminary assessment of the effects induced by the dynamic/impulsive loads allowed generally to verify the residual strength capability of the repository considered. The obtained preliminary results highlighted a remarkable potential to withstand the impact of military/large commercial aircraft, even in presence of ongoing concrete progressive failure (some penetration and spalling of the

  6. Preliminary safety analysis for key design features of KALIMER-600

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Y. B.; Chang, W. P.; Suk, S. D.; Ha, K. S.; Jeong, H. Y.; Heo, S

    2004-03-01

    KAERI is developing the conceptual design of a Liquid Metal Reactor, KALIMER-600 (Korea Advanced LIquid MEtal Reactor) under the Long-term Nuclear R and D Program. KALIMER-600 addresses key issues regarding future nuclear power plants such as plant safety, economics, proliferation, and waste. In this report, key safety design features are described and safety analyses results for typical ATWS accidents in the KALIMER design with breakeven core are presented. First, the basic approach to achieve the safety goal is introduced in Chapter 1, and the event categorization and acceptance criteria for the KALIMER-600 safety analysis are described in Chapter 2. In Chapter 3, results of inherent safety evaluations for the KALIMER-600 conceptual design are presented. The KALIMER-600 core and plant system are designed to assure benign performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated Anticipated Transient Without Scram (ATWS) have been performed using the SSC-K code to investigate the KALIMER-600 system response to the events. They are categorized as Bounding Events (BEs) because of their low probability of occurrence. In Chapter 4, the analysis of flow blockage for KALIMER-600 with the MATRA-LMR-FB code, which has been developed for the internal flow blockage in a LMR subassembly. The cases with a blockage of 6-subchannel, 24-subchannel, and 54-subchannel are analyzed.The performance analysis of the KALIMER-600 containment and some evaluations for the behaviors during HCDA will be performed later.

  7. Preliminary safety analysis for key design features of KALIMER

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, D. H.; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, S. O.; Lee, Y. B.; Jeong, K. S

    2000-07-01

    KAERI is currently developing the conceptual design of a liquid metal reactor, KALIMER(Korea Advanced Liquid Metal Reactor) under the long-term nuclear R and D program. In this report, descriptions of the KALIMER safety design features and safety analyses results for selected ATWS accidents are presented. First, the basic approach to achieve the safety goal is introduced in chapter 1, and the safety evaluation procedure for the KALIMER design is described in chapter 2. It includes event selection, event categorization, description of design basis events, and beyond design basis events. In chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. The KALIMER core and plant system are designed to assure design performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated anticipated transient without scram(ATWS) have been performed to investigate the KALIMER system response to the events. They are categorized as bounding events(BEs) because of their low probability of occurrence. In chapter 4, the design of the KALIMER containment dome and the results of its performance analysis are presented. The designs of the existing LMR containment and the KALIMER containment dome have been compared in this chapter. Procedure of the containment performance analysis and the analysis results are described along with the accident scenario and source terms. Finally, a simple methodology is introduced to investigate the core kinetics and hydraulic behavior during HCDA in chapter 5. Mathematical formulations have been developed in the framework of the modified bethe-tait method, and scoping analyses have been performed for the KALIMER core behavior during super-prompt critical excursions.

  8. Preliminary safety evaluation for the Laxemar subarea. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2006-03-15

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Laxemar subarea have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in 2000. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The latter is eventually done in coming Safety Assessments. This preliminary safety evaluation shows that, according to existing data, the Laxemar subarea meets all safety requirements. The evaluation also shows that the Laxemar subarea meets most of the safety preferences, but for some aspects of the site description further reduction of the uncertainties would enhance the safety case. Despite the stated concerns, there is no reason, from a safety point of view, not to continue the Site Investigations at the Laxemar subarea. There are uncertainties to resolve and the safety would eventually need to be verified through a proper safety assessment. Only some of the uncertainties noted in the Site Descriptive Model have safety implications and need further resolution for this reason. Furthermore, uncertainties may need resolving for other reasons, such as giving an adequate assurance of site understanding or assisting in optimising design. Notably, there are questions about the

  9. Alaska gold rush trails study: Preliminary draft

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Preliminary study draft, with maps, of seven gold rush trails in Alaska, to determine suitability for inclusion in the National Scenic Trails system and their...

  10. Preliminary investigation of interconnected systems interactions for the safety injection system of Indian Point-3

    Energy Technology Data Exchange (ETDEWEB)

    Alesso, H.P.; Lappa, D.A.; Smith, C.F.; Sacks, I.J.

    1983-03-04

    The rich diversity of ideas and techniques for analyzing interconnected systems interaction has presented the NRC with the problem of identifying methods appropriate for their own review and audit. This report presents the findings of a preliminary study using the Digraph Matrix Analysis method to evaluate interconnected systems interactions for the safety injection system of Indian Point-3. The analysis effort in this study was subjected to NRC constraints regarding the use of Boolean logic, the construction of simplified plant representations or maps, and the development of heuristic measures as specified by the NRC. The map and heuristic measures were found to be an unsuccessful approach. However, from the effort to model and analyze the Indian Point-3 safety injection system, including Boolean logic in the model, singleton and doubleton cut-sets were identified. It is recommended that efforts excluding Boolean logic and utilizing the NRC heuristic measures not be pursed further and that the Digraph Matrix approach (or other comparable risk assessment technique) with Boolean logic included to conduct the audit of the Indian Point-3 systems interaction study.

  11. Preliminary nuclear safety assessment of the NEPST (Topaz 2) space reactor program

    Science.gov (United States)

    Marshall, A. C.

    The United States (US) Strategic Defense Initiative Organization (SDIO) decided to investigate the possibility of launching a Russian Topaz 2 space nuclear power system. A preliminary nuclear safety assessment was conducted to determine whether or not a space mission could be conducted safely and within budget constraints. As part of this assessment, a safety policy and safety functional requirements were developed to guide both the safety assessment and future Topaz 2 activities. A review of the Russian flight safety program was conducted and documented. Our preliminary nuclear safety assessment included a number of deterministic analyses, such as the following: neutronic analysis of normal and accident configurations, an evaluation of temperature coefficients of reactivity, a reentry and disposal analysis, an analysis of postulated launch abort impact accidents, and an analysis of postulated propellant fire and explosion accidents. Based on the assessment to date, it appears that it will be possible to safely launch the Topaz 2 system in the US with a modification to preclude water flooded criticality. A full scale safety program is now underway.

  12. Preliminary safety evaluation (PSE) for Sodium Storage Facility at the Fast Flux Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    Bowman, B.R.

    1994-09-30

    This evaluation was performed for the Sodium Storage Facility (SSF) which will be constructed at the Fast Flux Test Facility (FFTF) in the area adjacent to the South and West Dump Heat Exchanger (DHX) pits. The purpose of the facility is to allow unloading the sodium from the FFTF plant tanks and piping. The significant conclusion of this Preliminary Safety Evaluation (PSE) is that the only Safety Class 2 components are the four sodium storage tanks and their foundations. The building, because of its imminent risk to the tanks under an earthquake or high winds, will be Safety Class 3/2, which means the building has a Safety Class 3 function with the Safety Class 2 loads of seismic and wind factored into the design.

  13. Deep repository for long-lived low- and intermediate-level waste. Preliminary safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-11-01

    A preliminary safety assessment has been performed of a deep repository for long-lived low- and intermediate-level waste, SFL 3-5. The purpose of the study is to investigate the capacity of the facility to act as a barrier to the release of radionuclides and toxic pollutants, and to shed light on the importance of the location of the repository site. A safety assessment (SR 97) of a deep repository for spent fuel has been carried out at the same time. In SR 97, three hypothetical repository sites have been selected for study. These sites exhibit fairly different conditions in terms of hydrogeology, hydrochemistry and ecosystems. To make use of information and data from the SR 97 study, we have assumed that SFL 3-5 is co-sited with the deep repository for spent fuel. A conceivable alternative is to site SFL 3-5 as a completely separate repository. The focus of the SFL 3-5 study is a quantitative analysis of the environmental impact for a reference scenario, while other scenarios are discussed and analyzed in more general terms. Migration in the repository's near- and far-field has been taken into account in the reference scenario. Environmental impact on the three sites has also been calculated. The calculations are based on an updated forecast of the waste to be disposed of in SFL 3-5. The forecast includes radionuclide content, toxic metals and other substances that have a bearing on a safety assessment. The safety assessment shows how important the site is for safety. Two factors stand out as being particularly important: the water flow at the depth in the rock where the repository is built, and the ecosystem in the areas on the ground surface where releases may take place in the future. Another conclusion is that radionuclides that are highly mobile and long-lived, such as {sup 36}Cl and {sup 93}Mo , are important to take into consideration. Their being long-lived means that barriers and the ecosystems must be regarded with a very long time horizon.

  14. Safety of high speed magnetic levitation transportation systems. Preliminary safety review of the transrapid maglev system

    Science.gov (United States)

    Dorer, R. M.; Hathaway, W. T.

    1990-11-01

    The safety of various magnetically levitated trains under development for possible implementation in the United States is of direct concern to the Federal Railroad Administration. Safety issues are addressed related to a specific maglev technology. The Transrapid maglev system was under development by the German Government over the last 10 to 15 years and was evolved into the current system with the TR-07 vehicle. A technically based safety review was under way over the last year by the U.S. Department of Transportation. The initial results of the review are presented to identify and assess potential maglev safety issues.

  15. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... that most of these have never been through a procedure of evaluation, but nonetheless are used to assist in making decisions that may directly affect the safety of the public and the environment. As a major funder of European research on major industrial hazards, DGXII is conscious of the importance......-tain model is appropriate for use in solving a given problem. Further, the findings from the REDIPHEM project related to dense gas dispersion will be highlighted. Finally, the paper will discuss the need for model quality assessment in safety studies....

  16. Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures.

    Science.gov (United States)

    Mash, D C; Kovera, C A; Pablo, J; Tyndale, R F; Ervin, F D; Williams, I C; Singleton, E G; Mayor, M

    2000-09-01

    Ibogaine is an indole alkaloid found in the roots of Tabernanthe Iboga (Apocynaceae family), a rain forest shrub that is native to western Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and thirst, and in higher doses as a sacrament in religious rituals. Members of American and European addict self-help groups have claimed that ibogaine promotes long-term drug abstinence from addictive substances, including psychostimulants and opiates. Anecdotal reports attest that a single dose of ibogaine eliminates opiate withdrawal symptoms and reduces drug craving for extended periods of time. The purported efficacy of ibogaine for the treatment of drug dependence may be due in part to an active metabolite. The majority of ibogaine biotransformation proceeds via CYP2D6, including the O-demethylation of ibogaine to 12-hydroxyibogamine (noribogaine). Blood concentration-time effect profiles of ibogaine and noribogaine obtained for individual subjects after single oral dose administrations demonstrate complex pharmacokinetic profiles. Ibogaine has shown preliminary efficacy for opiate detoxification and for short-term stabilization of drug-dependent persons as they prepare to enter substance abuse treatment. We report here that ibogaine significantly decreased craving for cocaine and heroin during inpatient detoxification. Self-reports of depressive symptoms were also significantly lower after ibogaine treatment and at 30 days after program discharge. Because ibogaine is cleared rapidly from the blood, the beneficial aftereffects of the drug on craving and depressed mood may be related to the effects of noribogaine on the central nervous system.

  17. Preliminary safety evaluation for 241-C-106 waste retrieval, project W-320

    Energy Technology Data Exchange (ETDEWEB)

    Conner, J.C.

    1994-10-18

    This document presents the Preliminary Safety Evaluation for Project W-320, Tank 241-C-106 Waste Retrieval Sluicing System (WRSS). The US DOE has been mandated to develop plans for response to safety issues associated with the waste storage tanks at the Hanford Site, and to report the progress of implementing those plans to Congress. The objectives of Project W-230 are to design, fabricate, develop, test, and operate a new retrieval system capable of removing a minimum of about 75% of the high-heat waste contained in C-106. It is anticipated that sluicing operations can remove enough waste to reduce the remaining radiogenic heat load to levels low enough to resolve the high-heat safety issue as well as allow closure of the tank safety issue.

  18. Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety

    Directory of Open Access Journals (Sweden)

    Lars Wojtecki

    2016-08-01

    Full Text Available Huntington’s disease (HD is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS of the pallidum is a promising symptomatic treatment targeting the core motor symptom: chorea. This article gives an overview of preliminary evidence on pathophysiology, safety and efficacy of DBS in HD.

  19. Nanotechnology Safety Self-Study

    Energy Technology Data Exchange (ETDEWEB)

    Grogin, Phillip W. [Los Alamos National Laboratory

    2016-03-29

    Nanoparticles are near-atomic scale structures between 1 and 100 nanometers (one billionth of a meter). Engineered nanoparticles are intentionally created and are used in research and development at Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL). This course, Nanotechnology Safety Self-Study, presents an overview of the hazards, controls, and uncertainties associated with the use of unbound engineered nanoscale particles (UNP) in a laboratory environment.

  20. Preliminary Study on Airlift Membran—Bioreactor

    Institute of Scientific and Technical Information of China (English)

    XUNong; XINGWeihong; 等

    2002-01-01

    A new type of membrane bioreactor named “airlift membrane-bioreactor”is discussed.For municipal wastewater reclamation,the preliminary study on airlift membrane-bioreactor shows its good performance such as high flux and lower energy consumption.The airlift membrane-bioreactor is potentially applicable in bioengineering and environmental protection fields.

  1. 1972 preliminary safety analysis report based on a conceptual design of a proposed repository in Kansas

    Energy Technology Data Exchange (ETDEWEB)

    Blomeke, J.O.

    1977-08-01

    This preliminary safety analysis report is based on a proposed Federal Repository at Lyons, Kansas, for receiving, handling, and depositing radioactive solid wastes in bedded salt during the remainder of this century. The safety analysis applies to a hypothetical site in central Kansas identical to the Lyons site, except that it is free of nearby salt solution-mining operations and bore holes that cannot be plugged to Repository specifications. This PSAR contains much information that also appears in the conceptual design report. Much of the geological-hydrological information was gathered in the Lyons area. This report is organized in 16 sections: considerations leading to the proposed Repository, design requirements and criteria, a description of the Lyons site and its environs, land improvements, support facilities, utilities, different impacts of Repository operations, safety analysis, design confirmation program, operational management, requirements for eventually decommissioning the facility, design criteria for protection from severe natural events, and the proposed program of experimental investigations. (DLC)

  2. Spiral 2: preliminary design study

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-11-15

    The scientific council of GANIL asked to perform a comparative study on the production methods based on gamma induced fission and rapid-neutron induced fission concerning the nature and the intensity of the neutron-rich products. The production rate expected should be around 10{sup 13} fissions per second. The study should include the implantation and the costs of the concerned accelerators. The scientific committee recommended also to study the possibility to re-inject the radioactive beams of SPIRAL-II in the cyclotrons available at GANIL in order to give access to an energy range from 1.7 to 100 MeV/nucleon. For that purpose, some study groups have been formed to evaluate the possibility of such a project in the different components: physics case, target-ion sources, drivers, post-acceleration and general infrastructure. The organization of the project study is given at the end of this report. The following report presents an overview of the study. Particularly the total costs have been assessed according to 3 options for the driver: 38.0*10{sup 6} euros for a 40 MeV deuteron linac, 18.7*10{sup 6} euros for a 45 MeV electron linac, and 29.1*10{sup 6} euros for a 80 MeV deuteron cyclotron.

  3. Institutional Repositories in India: A preliminary study

    OpenAIRE

    2011-01-01

    This preliminary study investigates various aspects of institutional repositories (IR’s) developed in India. The present study has identified the existence of 16 functional IRs some of which were not registered in any of the directories such as ROAR, Open DOAR. The study explores the timeline involved in planning, pilot testing, to system implementation of IR, exploratory activities conducted before implementing IR, its anticipated benefits.

  4. Worker Motivation Study: Preliminary Analysis.

    Science.gov (United States)

    Fulton, Margaret A.

    Since the Hawthorne Studies gave birth to the human relations approach to management, employee motivation, defined as an intervening variable(s) that accounts for factors within an individual that arouse, maintain, and channel behavior toward a goal, has been of much interest. An attempt was made to replicate the factor structure of the Wherry and…

  5. Preliminary Safety Analysis Report for the Transuranic Storage Area Retrieval Enclosure at the Idaho National Engineering Laboratory. Revision 8

    Energy Technology Data Exchange (ETDEWEB)

    1993-03-01

    This Transuranic Storage Area Retrieval Enclosure Preliminary Safety Analysis Report was completed as required by DOE Order 5480.23. The purpose of this document is to construct a safety basis that supports the design and permits construction of the facility. The facility has been designed to the requirements of a Radioactive Solid Waste Facility presented in DOE Order 6430.1A.

  6. Preliminary report: in-plant safety/relief valve discharge load test, Monticello Plant

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H.C. (comp.)

    1976-12-01

    This preliminary report covers the results of the test program of safety/relief valve (SRV) discharge load phenomena and the effects upon the Mark I primary containment torus structure of the Monticello Nuclear Power Plant. The objectives of the test were to provide a data base for verifying/improving analytical models and to measure the structural response of the torus to SRV discharges. Objectives, instrumentation, and test plan are described. Results of continuing data evaluation will be included in the final report scheduled for publication later in 1977.

  7. Comprehensive development plans for the low- and intermediate-level radioactive waste disposal facility in Korea and preliminary safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Kang Il; Kim, Jin Hyeong; Kwon, Mi Jin; Jeong, Mi Seon; Hong, Sung Wook; Park, Jin Beak [Korea Radioactive Waste Agency, Daejeon (Korea, Republic of)

    2016-12-15

    The disposal facility in Gyeongju is planning to dispose of 800,000 packages of low- and intermediate- level radioactive waste. This facility will be developed as a complex disposal facility that has various types of disposal facilities and accompanying management. In this study, based on the comprehensive development plan of the disposal facility, a preliminary post-closure safety assessment is performed to predict the phase development of the total capacity for the 800,000 packages to be disposed of at the site. The results for each scenario meet the performance target of the disposal facility. The assessment revealed that there is a significant impact of the inventory of intermediate-level radionuclide waste on the safety evaluation. Due to this finding, we introduce a disposal limit value for intermediate-level radioactive waste. With stepwise development of safety case, this development plan will increase the safety of disposal facilities by reducing uncertainties within the future development of the underground silo disposal facilities.

  8. Preliminary safety evaluation for the Simpevarp subarea. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-04-01

    The main objectives of this Preliminary safety evaluation (PSE) of the Simpevarp subarea are: to determine, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB in the report SKB-TR--00-12. These criteria both concern properties of the site judged to be necessary for safety and engineering (requirements) and properties judged to be beneficial (preferences). The findings are then evaluated in order to provide feedback to continued investigations and design work. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that even considering remaining uncertainties, the Simpevarp subarea meets all safety requirements and most of the safety preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Simpevarp subarea. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Still, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry within the Simpevarp subarea would allow for a more specified layout, although the sensitivity analysis shows that the space needed is rather robust with respect to uncertainties in the zones. There is substantial uncertainty in the discrete fracture network (DFN

  9. Preliminary safety analysis of high-intensity interval training (HIIT) in persons with chronic stroke.

    Science.gov (United States)

    Carl, Daniel L; Boyne, Pierce; Rockwell, Bradley; Gerson, Myron; Khoury, Jane; Kissela, Brett; Dunning, Kari

    2017-03-01

    The purpose of this study was to assess safety via electrocardiographic (ECG), blood pressure (BP), heart rate (HR), and orthopedic responses to 3 different high-intensity interval training (HIIT) protocols in persons with stroke. Eighteen participants (10 male; 61.9 + 8.3 years of age; 5.8 + 4.2 years poststroke) completed a symptom-limited graded exercise test (GXT) with ECG monitoring to screen for eligibility and determine HR peak. The 3 HIIT protocols involved repeated 30 s bursts of treadmill walking at maximum speed alternated with rest periods of 30 s (P30), 1 min (P60), or 2 min (P120). Sessions were performed in random order and included 5 min warm up, 20 min HIIT, and 5 min cool down. Variables measured included ECG activity, BP, HR, signs and symptoms of cardiovascular intolerance, and orthopedic concerns. Generalized linear mixed models and Tukey-Kramer adjustment were used to compare protocols using p HIIT session. HIIT elicited HRs in excess of 88% of measured HRpeak including 6 (P30), 8 (P60), and 2 (P120) participants eliciting a HR response above their GXT HRpeak. Both maximum BP and HR were significantly higher in P30 and P60 relative to P120. Preliminary data indicate that persons with chronic stroke who have been prescreened with an ECG stress test, a symptom-limited GXT, and a harness for fall protection may safely participate in HIIT, generating substantially higher HRs than what is seen in traditional moderate intensity training.

  10. preliminary study of American legal culture

    Institute of Scientific and Technical Information of China (English)

    周杨

    2016-01-01

    This thesis is a preliminary study of American legal culture. Nowadays more and more scholars see the importance of legal culture and do studies on it. The author selects a number of American legal TV plays and movies; analyzes their topics, main characters, and plots; then finds out why United States adopt the legal system; what kind of legal culture it has; and how the legal culture is reflected in those movies and TV plays. The author hopes this thesis can work not only as an insight into the American legal culture, but also a source of reference for china to improve its legal system.

  11. Group theories: relevance to group safety studies.

    Science.gov (United States)

    Benevento, A L

    1998-01-01

    Promoting safety in the workplace has been attempted in a variety of ways. Increasingly, industries are using groups such as safety teams and quality circles to promote worker safety. Group influences on individual behavior and attitudes have long been studied in the social psychology literature, but the theories have not been commonly found outside the psychology arena. This paper describes the group theories of group polarization, risky shift, social loafing, groupthink and team think and attempts to apply these theories to existing studies that examine work group influences on safety. Interesting parallels were found but only one study examined group influences as their primary focus of research. Since groups are increasingly used for safety promotion, future research on safety that studies group influences with respect to current group theories is recommended.

  12. Preliminary Results of Ancillary Safety Analyses Supporting TREAT LEU Conversion Activities

    Energy Technology Data Exchange (ETDEWEB)

    Brunett, A. J. [Argonne National Lab. (ANL), Argonne, IL (United States); Fei, T. [Argonne National Lab. (ANL), Argonne, IL (United States); Strons, P. S. [Argonne National Lab. (ANL), Argonne, IL (United States); Papadias, D. D. [Argonne National Lab. (ANL), Argonne, IL (United States); Hoffman, E. A. [Argonne National Lab. (ANL), Argonne, IL (United States); Kontogeorgakos, D. C. [Argonne National Lab. (ANL), Argonne, IL (United States); Connaway, H. M. [Argonne National Lab. (ANL), Argonne, IL (United States); Wright, A. E. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-10-01

    Report (FSAR) [3]. Depending on the availability of historical data derived from HEU TREAT operation, results calculated for the LEU core are compared to measurements obtained from HEU TREAT operation. While all analyses in this report are largely considered complete and have been reviewed for technical content, it is important to note that all topics will be revisited once the LEU design approaches its final stages of maturity. For most safety significant issues, it is expected that the analyses presented here will be bounding, but additional calculations will be performed as necessary to support safety analyses and safety documentation. It should also be noted that these analyses were completed as the LEU design evolved, and therefore utilized different LEU reference designs. Preliminary shielding, neutronic, and thermal hydraulic analyses have been completed and have generally demonstrated that the various LEU core designs will satisfy existing safety limits and standards also satisfied by the existing HEU core. These analyses include the assessment of the dose rate in the hodoscope room, near a loaded fuel transfer cask, above the fuel storage area, and near the HEPA filters. The potential change in the concentration of tramp uranium and change in neutron flux reaching instrumentation has also been assessed. Safety-significant thermal hydraulic items addressed in this report include thermally-induced mechanical distortion of the grid plate, and heating in the radial reflector.

  13. A preliminary neutron crystallographic study of thaumatin

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Susana C. M. [ILL-EMBL Deuteration Laboratory, Partnership for Structural Biology, 6 Rue Jules Horowitz, 38042 Grenoble (France); Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom); Blakeley, Matthew P. [Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); Leal, Ricardo M. F. [ILL-EMBL Deuteration Laboratory, Partnership for Structural Biology, 6 Rue Jules Horowitz, 38042 Grenoble (France); Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom); ESRF, 6 Rue Jules Horowitz, BP-220, 38043 Grenoble (France); Mitchell, Edward P. [EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom); ESRF, 6 Rue Jules Horowitz, BP-220, 38043 Grenoble (France); Forsyth, V. Trevor, E-mail: tforsyth@ill.fr [ILL-EMBL Deuteration Laboratory, Partnership for Structural Biology, 6 Rue Jules Horowitz, 38042 Grenoble (France); Institut Laue Langevin, 6 Rue Jules Horowitz, 38042 Grenoble (France); EPSAM and ISTM, Keele University, Staffordshire ST5 5BG (United Kingdom)

    2008-05-01

    Preliminary neutron crystallographic data from the sweet protein thaumatin have been recorded using the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results illustrate the feasibility of a full neutron structural analysis aimed at further understanding the molecular basis of the perception of sweet taste. Such an analysis will exploit the use of perdeuterated thaumatin. A preliminary neutron crystallographic study of the sweet protein thaumatin is presented. Large hydrogenated crystals were prepared in deuterated crystallization buffer using the gel-acupuncture method. Data were collected to a resolution of 2 Å on the LADI-III diffractometer at the Institut Laue Langevin (ILL). The results demonstrate the feasibility of a full neutron crystallographic analysis of this structure aimed at providing relevant information on the location of H atoms, the distribution of charge on the protein surface and localized water in the structure. This information will be of interest for understanding the specificity of thaumatin–receptor interactions and will contribute to further understanding of the molecular mechanisms underlying the perception of taste.

  14. Preliminary Authorization Basis Documentation for the Proposed Bio Safety Level 3 (BSl-3) Facility

    Energy Technology Data Exchange (ETDEWEB)

    Altenbach, T J; Nguyen, S N

    2003-09-20

    Lawrence Livermore National Laboratory (LLNL) is proposing to construct a biosafety level (BSL-3) facility at Site 200 in Livermore, California. Biosafety level 3 (BSL-3) is a designation assigned by the Centers for Disease Control and Prevention (CDC) and National Institutes Health (NIH) for handling infectious organisms based on the specific microorganisms and associated operations. Biosafety levels range from BSL-1 (lowest hazard) to BSL-4 (highest hazard). Details about the BSL-3 criteria are described in the Center of Disease Control and Prevention (CDC)/National Institutes of Health (NIH)'s publication ''Biosafety Microbiological and Biomedical Laboratories'' (BMBL), 4th edition (CDC 1999): The BSL-3 facility will be built in accordance with the required BMBL guidelines. This Preliminary Authorization Basis Documentation (PABD) for the proposed BSL-3 facility has been prepared in accordance with the current contractual requirements at LLNL. This includes the LLNL Environment, Safety, and Health Manual (ES&H Manual) and applicable Work Smart Standards, including the biosafety standards, such as the aforementioned BMBL and the NIH Guidelines for Research Involving Recombinant DNA Molecules: The proposed BSL-3 facility is a 1,100 ft{sup 2}, one-story permanent prefabricated facility, which will have three individual BSL-3 laboratory rooms (one of which is an animal biosafety level-3 [ABSL-3] laboratory to handle rodents), a mechanical room, clothes-change and shower rooms, and small storage space (Figure 3.1). The BSL-3 facility will be designed and operated accordance with guidelines for BSL-3 laboratories established by the CDC and the NIH. No radiological, high explosives, fissile, or propellant material will be used or stored in the proposed BSL-3 facility. The BSL-3 facility will be used to develop scientific tools to identify and understand the pathogens of medical, environmental, and forensic importance. Microorganisms that are to

  15. Los Alamos National Laboratory corregated metal pipe saw facility preliminary safety analysis report. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-09-19

    This Preliminary Safety Analysis Report addresses site assessment, facility design and construction, and design operation of the processing systems in the Corrugated Metal Pipe Saw Facility with respect to normal and abnormal conditions. Potential hazards are identified, credible accidents relative to the operation of the facility and the process systems are analyzed, and the consequences of postulated accidents are presented. The risk associated with normal operations, abnormal operations, and natural phenomena are analyzed. The accident analysis presented shows that the impact of the facility will be acceptable for all foreseeable normal and abnormal conditions of operation. Specifically, under normal conditions the facility will have impacts within the limits posted by applicable DOE guidelines, and in accident conditions the facility will similarly meet or exceed the requirements of all applicable standards. 16 figs., 6 tabs.

  16. Preliminary safety criteria for organic watch list tanks at the Hanford site

    Energy Technology Data Exchange (ETDEWEB)

    Webb, A.B.; Stewart, J.L.; Turner, O.A. [Westinghouse Hanford Co., Richland, WA (United States); Plys, M.G.; Malinovic, B. [Fauske and Associates, Inc., Burr Ridge, IL (United States); Grigsby, J.M. [G & P Consulting, Inc. (United States); Camaioni, D.M.; Heasler, P.G.; Samuels, W.O.; Toth, J.J. [Pacific Northwest Lab., Portland, OR (United States)

    1995-11-01

    Condensed-phase, rapid reactions of organic salts with nitrates/nitrites in Hanford High Level Radioactive Waste single-shell tanks could lead to structural failure of the tanks resulting in significant releases of radionuclides and toxic materials. This report establishes appropriate preliminary safety criteria to ensure that tank wastes will be maintained safe. These criteria show that if actual dry wastes contain less than 1.2 MJ/kg of reactants reaction energy or less 4.5 wt % of total organic carbon, then the waste will be safe and will not propagate if ignited. Waste moisture helps to retard reactions; when waste moisture exceeds 20 wt %, rapid reactions are prevented, regardless of organic carbon concentrations. Aging and degradation of waste materials has been considered to predict the types and amounts to organic compounds present in the waste. Using measurements of 3 waste phases (liquid, salt cake, and sludge) obtained from tank waste samples analyzed in the laboratory, analysis of variance (ANOVA) models were used to estimate waste states for unmeasured tanks. The preliminary safety criteria are based upon calorimetry and propagation testing of likely organic compounds which represent actual tank wastes. These included sodium salts of citrate, formate, acetate and hydroxyethylethylenediaminetricetate (HEDTA). Hot cell tests of actual tank wastes are planned for the future to confirm propagation tests performed in the laboratory. The effects of draining liquids from the tanks which would remove liquids and moisture were considered because reactive waste which is too dry may propagate. Evaporation effects which could remove moisture from the tanks were also calculated. The various ways that the waste could be heated or ignited by equipment failures or tank operations activities were considered and appropriate monitoring and controls were recommended.

  17. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2005-08-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Forsmark area have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that, even considering remaining uncertainties, the Forsmark area meets all stated safety requirements and preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Forsmark area. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Nevertheless, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry inside the target area would be needed to more firmly define locations of the suitable deposition volumes. There is substantial uncertainty in the Discrete Fracture Network model. Further reduction of the uncertainties, if needed, would probably only be possible from the underground, detailed investigation phase. Efforts need also be spent on improving the DFN-modelling. There are assumptions made in current models that could be challenged and there seems to be room for better use of the borehole information. It is particularly important to

  18. Preliminary safety evaluation for the Forsmark area. Based on data and site descriptions after the initial site investigation stage

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden)

    2005-08-01

    The main objectives of this Preliminary Safety Evaluation (PSE) of the Forsmark area have been to determine, with limited efforts, whether the feasibility study's judgement of the suitability of the candidate area with respect to long-term safety holds up in the light of the actual site investigation data; to provide feedback to continued site investigations and site-specific repository design and to identify site-specific scenarios and geoscientific issues for further analyses. The PSE focuses on comparing the attained knowledge of the sites with the suitability criteria as set out by SKB. The PSE does not aim at comparing sites and does not assess compliance with safety and radiation protection criteria. The evaluation shows that, even considering remaining uncertainties, the Forsmark area meets all stated safety requirements and preferences. Consequently, from a safety point of view, there is no reason not to continue the Site Investigations of the Forsmark area. There are still uncertainties to resolve and the safety would eventually need to be verified through a full safety assessment. Nevertheless, this Preliminary Safety Evaluation demonstrates that it is likely that a safe repository for spent nuclear fuel of the KBS-3 type could be constructed at the site. The following feedback is provided to the site investigations and the associated site modelling: Reducing the uncertainty on the deformation zone geometry inside the target area would be needed to more firmly define locations of the suitable deposition volumes. There is substantial uncertainty in the Discrete Fracture Network model. Further reduction of the uncertainties, if needed, would probably only be possible from the underground, detailed investigation phase. Efforts need also be spent on improving the DFN-modelling. There are assumptions made in current models that could be challenged and there seems to be room for better use of the borehole information. It is particularly important to

  19. Preliminary study of radium-contaminated soils

    Energy Technology Data Exchange (ETDEWEB)

    Healy, J.W.; Rodgers, J.C.

    1978-10-01

    A preliminary study was made of the potential radiation exposures to people from radium-226 contamination in the soil in order to provide guidance on limits to be applied in decontaminating land. Pathways included were inhalation of radium from resuspension; ingestion of radium with foods; external gamma radiation from radium daughters; inhalation of radon and daughter, both in the open air and in houses; and the intake of /sup 210/Pb and /sup 210/Po from both inhalation and ingestion. The depth of the contaminated layer is of importance for external exposure and especially for radon emanation. The most limiting pathway was found to be emanation of the radon into buildings with limiting values comparable to those found naturally in many areas.

  20. Preliminary Safety Design Report for Remote Handled Low-Level Waste Disposal Facility

    Energy Technology Data Exchange (ETDEWEB)

    Timothy Solack; Carol Mason

    2012-03-01

    A new onsite, remote-handled low-level waste disposal facility has been identified as the highest ranked alternative for providing continued, uninterrupted remote-handled low-level waste disposal for remote-handled low-level waste from the Idaho National Laboratory and for nuclear fuel processing activities at the Naval Reactors Facility. Historically, this type of waste has been disposed of at the Radioactive Waste Management Complex. Disposal of remote-handled low-level waste in concrete disposal vaults at the Radioactive Waste Management Complex will continue until the facility is full or until it must be closed in preparation for final remediation of the Subsurface Disposal Area (approximately at the end of Fiscal Year 2017). This preliminary safety design report supports the design of a proposed onsite remote-handled low-level waste disposal facility by providing an initial nuclear facility hazard categorization, by discussing site characteristics that impact accident analysis, by providing the facility and process information necessary to support the hazard analysis, by identifying and evaluating potential hazards for processes associated with onsite handling and disposal of remote-handled low-level waste, and by discussing the need for safety features that will become part of the facility design.

  1. Study on safety cost and insurance degree of coal enterprises

    Energy Technology Data Exchange (ETDEWEB)

    Liang, M.; Han, C.; Yang, G. [Shandong Institute of Business and Technology, Yantai (China)

    2007-06-15

    The study confirmed the safety insurance degree of coal enterprises based on the various components of safety cost and analysed the connection between safety cost of component parts and safety insurance degree. Using Matlab software, a functional relationship was derived between mimesis curves of safety losing expenses, safety assets and management expenses, safety cost and safety insurance degree. The cost of a safety programme was forecast on the basis of this functional relationship. 3 figs., 3 tabs.

  2. Preliminary design study of the TMT Telescope structure system: overview

    Science.gov (United States)

    Usuda, Tomonori; Ezaki, Yutaka; Kawaguchi, Noboru; Nagae, Kazuhiro; Kato, Atsushi; Takaki, Junji; Hirano, Masaki; Hattori, Tomoya; Tabata, Masaki; Horiuchi, Yasushi; Saruta, Yusuke; Sofuku, Satoru; Itoh, Noboru; Oshima, Takeharu; Takanezawa, Takashi; Endo, Makoto; Inatani, Junji; Iye, Masanori; Sadjadpour, Amir; Sirota, Mark; Roberts, Scott; Stepp, Larry

    2014-07-01

    We present an overview of the preliminary design of the Telescope Structure System (STR) of Thirty Meter Telescope (TMT). NAOJ was given responsibility for the TMT STR in early 2012 and engaged Mitsubishi Electric Corporation (MELCO) to take over the preliminary design work. MELCO performed a comprehensive preliminary design study in 2012 and 2013 and the design successfully passed its Preliminary Design Review (PDR) in November 2013 and April 2014. Design optimizations were pursued to better meet the design requirements and improvements were made in the designs of many of the telescope subsystems as follows: 1. 6-legged Top End configuration to support secondary mirror (M2) in order to reduce deformation of the Top End and to keep the same 4% blockage of the full aperture as the previous STR design. 2. "Double Lower Tube" of the elevation (EL) structure to reduce the required stroke of the primary mirror (M1) actuators to compensate the primary mirror cell (M1 Cell) deformation caused during the EL angle change in accordance with the requirements. 3. M1 Segment Handling System (SHS) to be able to make removing and installing 10 Mirror Segment Assemblies per day safely and with ease over M1 area where access of personnel is extremely difficult. This requires semi-automatic sequence operation and a robotic Segment Lifting Fixture (SLF) designed based on the Compliance Control System, developed for controlling industrial robots, with a mechanism to enable precise control within the six degrees of freedom of position control. 4. CO2 snow cleaning system to clean M1 every few weeks that is similar to the mechanical system that has been used at Subaru Telescope. 5. Seismic isolation and restraint systems with respect to safety; the maximum acceleration allowed for M1, M2, tertiary mirror (M3), LGSF, and science instruments in 1,000 year return period earthquakes are defined in the requirements. The Seismic requirements apply to any EL angle, regardless of the

  3. Randomized adjuvant study comparing two schemes of 5-fluorouracil and leucovorin in stage B2 and C colon adenocarcinoma: study design and preliminary safety results. Groupe d'Etude et de Recherche Clinique en Oncologie Radiotherapies.

    Science.gov (United States)

    André, T; Colin, P; Louvet, C; Gamelin, E; Bouche, O; Achille, E; Colbert, N; Boaziz, C; Piedbois, P; Tubiana-Mathieu, N; Boutan-Laroze, A; Flesch, M; Billiau, V; Buyse, M; Gramont, A

    2001-02-01

    The aim of this randomized open-label study was to compare a bimonthly with a monthly regimen of 5-fluorouracil (5-FU) and leucovorin for the adjuvant treatment of colon and high-rectum adenocarcinoma. The bimonthly regimen was administered for 2 consecutive days every 14 days as d,L-leucovorin 200 mg/m2 or L-leucovorin 100 mg/m2 as a 2-hour infusion followed by 5-FU bolus of 400 mg/m2 and a 600 mg/m2 5-FU 22-hour continuous infusion (LVSFU2). In the monthly regimen, d,L-leucovorin 200 mg/m2 or L-leucovorin 100 mg/m2 15-minute infusion followed by a 400 mg/m2 15 minute 5-FU bolus was administered for 5 consecutive days every 28 days (FUFOL). Nine hundred five patients with recently resected stage B2 or C colon or high-rectum adenocarcinoma (inferior pole of the tumor subperitoneal) were recruited into the study. Patients were randomized in a 2 x 2 factorial design to receive either LV5FU2 or FUFOL for 24 or 36 weeks. Characteristics of the patients in the two different treatment groups were similar at baseline. Compliance was good. Mean 5-FU dose intensities were 930 mg/ m2/wk and 463 mg/m2/wk for LVSFU2 and FUFOL, respectively. The incidence of maximal grade III-IV toxicities for LVSFU2 and FUFOL was neutropenia 6% and 16% (P < .001), diarrhea 4% and 10% (P < .001), and mucositis 2% and 7% (P < .001), respectively. Maximum grade III-IV toxicities in the LV5FU2 treatment group were significantly lower than in the FUFOL group (10% v 26%; P < .001). Although patients in the LV5FU2 group received twice the dose of 5-FU compared with those in the FUFOL group, LV5FU2 was shown to be less toxic. Efficacy data will be available in 2001.

  4. Impromptu Speaking and Interpretation Studies: A Preliminary Study

    Science.gov (United States)

    Heinz, Michael

    2013-01-01

    The purpose of this preliminary study was to look at forensics-based competition events and determine what, if any, impact they could have on the language learning and public speaking skills of interpreters in training. This paper details the nature of the impromptu and extemporaneous speaking events in forensics competitions and introduces a…

  5. Impromptu Speaking and Interpretation Studies: A Preliminary Study

    Science.gov (United States)

    Heinz, Michael

    2013-01-01

    The purpose of this preliminary study was to look at forensics-based competition events and determine what, if any, impact they could have on the language learning and public speaking skills of interpreters in training. This paper details the nature of the impromptu and extemporaneous speaking events in forensics competitions and introduces a…

  6. Flammable Gas Safety Self-Study 52827

    Energy Technology Data Exchange (ETDEWEB)

    Glass, George [Los Alamos National Laboratory

    2016-03-17

    This course, Flammable Gas Safety Self-Study (COURSE 52827), presents an overview of the hazards and controls associated with commonly used, compressed flammable gases at Los Alamos National Laboratory (LANL).

  7. Preliminary Analysis of a Steam Line Break Accident with the MARS-KS code for the SMART Design with Passive Safety Systems

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Doohyuk; Ko, Yungjoo; Suh, Jaeseung [Hannam Univ., Daejeon (Korea, Republic of); Bae, Hwang; Ryu, Sunguk; Yi, Sungjae; Park, Hyunsik [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    SMART has been developed by KAERI, and SMART-Standard Design Approval (SDA) was recently granted in 2012. A SMART design with Passive Safety System (PSS) features (called SMART-PSS) is being developed and added to the standard design of SMART by KAERI to improve its safety system. Active safety systems such as safety injection pumps will be replaced by a passive safety system, which is actuated only by the gravity force caused by the height difference. All tanks for the passive safety systems are higher than the injection nozzle, which is located around the reactor coolant pumps (RCPs). In this study, a preliminary analysis of the main steam line break accident (MSLB) was performed using the MARS-KS code to understand the general behavior of the SMART-PSS design and to prepare its validation test with the SMART-ITL (FESTA) facility. An anticipated accident for the main steam line break (MSLB) was performed using the MARS-KS code to understand the thermal-hydraulic behaviors of the SMART-PSS design. The preliminary analysis provides good insight into the passive safety system design features of the SMART-PSS and the thermal-hydraulic characteristics of the SMART design. The analysis results of the MSLB showed that the core water collapsed level inside the core support barrel was maintained high over the active core top level during the transient period. Therefore, the SMART-PSS design has satisfied the requirements to maintain the plant at a safe shutdown condition during 72 hours without AC power or operator action after an anticipated accident.

  8. Preliminary safety calculations to improve the design of Molten Salt Fast Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Brovchenko, M.; Heuer, D.; Merle-Lucotte, E.; Allibert, M.; Capellan, N.; Ghetta, V.; Laureau, A. [LPSC, CNRS/IN2P3, Grenoble INP, 53,rue des Martyrs, 38026 Grenoble Cedex (France)

    2012-07-01

    Molten salt reactors are liquid fuel reactors so that they are flexible in operation but very different in the safety approach from solid fuel reactors. This study bears on the specific concept named Molten Salt Fast Reactor (MSFR). Since this new nuclear technology is in development, safety is an essential point to be considered all along the R and D studies. This paper presents the first step of the safety approach: the systematic description of the MSFR, limited here to the main systems surrounding the core. This systematic description is the basis on which we will be able to devise accidental scenarios. Thanks to the negative reactivity feedback coefficient, most accidental scenarios lead to reactor shut down. Because of the decay heat generated in the fuel salt, it must be cooled. After the description of the tools developed to calculate the residual heat, the different contributions are discussed in this study. The decay heat of fission products in the MSFR is evaluated to be low (3% of nominal power), mainly due to the reprocessing that transfers the fission products to the gas reprocessing unit. As a result, the contribution of the actinides is significant (0.5% of nominal power). The unprotected loss of heat sink transients are studied in this paper. It appears that slow transients are favorable (> 1 min) to minimize the temperature increase of the fuel salt. This work will be the basis of further safety studies as well as an essential parameter for the design of the draining system. (authors)

  9. Criticality safety basics, a study guide

    Energy Technology Data Exchange (ETDEWEB)

    V. L. Putman

    1999-09-01

    This document is a self-study and classroom guide, for criticality safety of activities with fissile materials outside nuclear reactors. This guide provides a basic overview of criticality safety and criticality accident prevention methods divided into three parts: theory, application, and history. Except for topic emphasis, theory and history information is general, while application information is specific to the Idaho National Engineering and Environmental Laboratory (INEEL). Information presented here should be useful to personnel who must know criticality safety basics to perform their assignments safely or to design critically safe equipment or operations. However, the guide's primary target audience is fissile material handler candidates.

  10. Preliminary study natural gas; Foerstudie naturgas

    Energy Technology Data Exchange (ETDEWEB)

    Lamnevik, Stefan; Carlsson, Tomas; Dyhr, Kurt

    2000-09-01

    FOA has carried out a preliminary study on natural gas for the Swedish National Energy Administration. To use natural gas as an energy source could be one step towards use of carbon-free fuels such as hydrogen. Natural gas, consisting mainly of methane, is the hydrocarbon with the highest hydrogen content. It has a high heat of combustion, 55 MJ/kg, and a low emission of carbon dioxide, 2.8 kg/kg fuel or 0.051 kg/MJ. The carbon dioxide emission per energy unit is twice as high for coal, 75% higher for wood fuels, and 27% higher for fuel oils. The Swedish natural gas network starts at Malmoe and ends at Hyltebruk. The natural gas used is imported from Denmark by Sydgas AB. It would be possible in the future to get connections to the Russian and the Norwegian networks and also to import LNG by ship and store it to buffer the different consumption demands during summer and winter. Natural gas is non-toxic but can be suffocating due to too low oxygen content at high concentrations. Combustion with an inadequate air supply will form toxic carbon monoxide like other carbonaceous fuels. Natural gas/air mixtures may explode like other gaseous fuels. The gas is lighter than air and is therefore dispersed better than heavier gases like LPG. Natural gas is difficult to detonate unlike other gases.

  11. Documentation of Hanford Site independent review of the Hanford Waste Vitrification Plant Preliminary Safety Analysis Report. Revision 3

    Energy Technology Data Exchange (ETDEWEB)

    Herborn, D.I.

    1993-11-01

    Westinghouse Hanford Company (WHC) is the Integrating Contractor for the Hanford Waste Vitrification Plant (HWVP) Project, and as such is responsible for preparation of the HWVP Preliminary Safety Analysis Report (PSAR). The HWVP PSAR was prepared pursuant to the requirements for safety analyses contained in US Department of Energy (DOE) Orders 4700.1, Project Management System (DOE 1987); 5480.5, Safety of Nuclear Facilities (DOE 1986a); 5481.lB, Safety Analysis and Review System (DOE 1986b) which was superseded by DOE order 5480-23, Nuclear Safety Analysis Reports, for nuclear facilities effective April 30, 1992 (DOE 1992); and 6430.lA, General Design Criteria (DOE 1989). The WHC procedures that, in large part, implement these DOE requirements are contained in WHC-CM-4-46, Nonreactor Facility Safety Analysis Manual. This manual describes the overall WHC safety analysis process in terms of requirements for safety analyses, responsibilities of the various contributing organizations, and required reviews and approvals.

  12. 冶金工贸行业小微企业安全标准化管理信息系统的研究%A Preliminary Study on Safety Standardization Management Information System of Small and Micro Metallurgical Businesses

    Institute of Scientific and Technical Information of China (English)

    程新

    2014-01-01

    分析了冶金等工贸行业小微企业安全标准化管理系统的11个要素,确定管理信息系统的主要目标及使用的关键技术特点,建立了对应的11个功能模块,并对管理信息系统各模块实现的功能进行了介绍。将冶金等工贸行业小微企业安全标准化管理设定的各类安全信息及安全管理内容融入到信息系统管理之中,实现了对安全管理过程中大量积累数据的分析和处理,实时动态地展示工艺、环境、设备、安全、管理状况和员工的危险行为,可以及时有效地进行风险控制,达到降低事故发生的目的。%By analyzing the 11 essentials in safety standardization management system of small and micro metallurgical industry and trade businesses, the main objectives and key technical characteristics of the system are determined, 11 corresponding functional modules are established and realization methods of the modules are introduced. Various types of safety in-formation and management contents set by safety standardization management for small and micro metallurgical industry and trade businesses are integrated into the information system management to achieve analysis and processing lots of accumulated data in safety management process. Thus potential risks in processes, environment, equipment, security, management con-ditions and staff behaviors can be dynamically displayed real-timely, so that risk control can be effectively carried out to reduce accident occurrence.

  13. Hydrogen Gas Retention and Release from WTP Vessels: Summary of Preliminary Studies

    Energy Technology Data Exchange (ETDEWEB)

    Gauglitz, Phillip A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bontha, Jagannadha R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Daniel, Richard C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mahoney, Lenna A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Rassat, Scot D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wells, Beric E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bao, Jie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Boeringa, Gregory K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Buchmiller, William C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Burns, Carolyn A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chun, Jaehun [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Karri, Naveen K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Li, Huidong [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tran, Diana N. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-07-01

    The Hanford Waste Treatment and Immobilization Plant (WTP) is currently being designed and constructed to pretreat and vitrify a large portion of the waste in the 177 underground waste storage tanks at the Hanford Site. A number of technical issues related to the design of the pretreatment facility (PTF) of the WTP have been identified. These issues must be resolved prior to the U.S. Department of Energy (DOE) Office of River Protection (ORP) reaching a decision to proceed with engineering, procurement, and construction activities for the PTF. One of the issues is Technical Issue T1 - Hydrogen Gas Release from Vessels (hereafter referred to as T1). The focus of T1 is identifying controls for hydrogen release and completing any testing required to close the technical issue. In advance of selecting specific controls for hydrogen gas safety, a number of preliminary technical studies were initiated to support anticipated future testing and to improve the understanding of hydrogen gas generation, retention, and release within PTF vessels. These activities supported the development of a plan defining an overall strategy and approach for addressing T1 and achieving technical endpoints identified for T1. Preliminary studies also supported the development of a test plan for conducting testing and analysis to support closing T1. Both of these plans were developed in advance of selecting specific controls, and in the course of working on T1 it was decided that the testing and analysis identified in the test plan were not immediately needed. However, planning activities and preliminary studies led to significant technical progress in a number of areas. This report summarizes the progress to date from the preliminary technical studies. The technical results in this report should not be used for WTP design or safety and hazards analyses and technical results are marked with the following statement: “Preliminary Technical Results for Planning – Not to be used for WTP Design

  14. A Study on Methodologies for Assessing Safety Critical Network's Risk Impact on Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Lim, T. J.; Park, S. K.; Seo, S. J. [Soongsil Univ., Seoul (Korea, Republic of)

    2007-04-15

    The objectives of this project is to establish methodologies for assessing safety-critical network's risk impact on nuclear power plant by developing reliability analysis models for the safety-critical network. It is essential to develop reliability analysis models for safety-critical network, and it is very important to adapt the model to the current methodologies for assessing risk impact on nuclear power plants. Major outputs of the first year study are preliminary models for assessing reliability of safety-critical communication networks and those of the second year study are methodologies for assessing safety-critical network's risk impact on nuclear power plant.

  15. Preliminary pharmacological investigation of the ischuretic property and safety of a hydro-ethanolic extract of Amaranthus spinosis (Fam: Amaranthaceae

    Directory of Open Access Journals (Sweden)

    George A. Koffuor

    2013-10-01

    Full Text Available Background: Ischuria is a health and social problem, having a negative impact on sufferers. This study therefore was a preliminary investigation of the ischuretic property and safety for use of a hydro-ethanolic extract of Amaranthus spinosus used traditionally in managing ischuria. Methods: Phytochemical screening, thin layer chromatography and high performance liquid chromatography were performed on the extract to establish fingerprints for identification. Acetylcholine, Nicotine, and the extract were applied to an isolated rat urinary bladder to ascertain contractile response. The possible receptor site(s of action was also investigated using isolated rabbit jejunum, and guinea-pig ileum preparations. In-house observation, hematological analysis, and liver and kidney function tests were performed on Sprague-Dawley rats, in acute and sub-acute toxicity studies. Results: The extract had contractile effects on the rat urinary bladder (similar to acetylcholine and nicotine and rabbit jejunum. Its contractile effect of the guinea-pig ileum was significantly inhibited by hexamethonium (77.50 ± 8.50 %; P ≤ 0.001 and to a lesser extent by mepyramine (49.2 ± 6.80 %; P ≤ 0.001 and Atropine (22.45 ± 5.22 %; P ≤ 0.01. The extract (80-800 mg kg-1 was not lethal and a 160 and 240 mg kg-1 dose had no adverse effect on blood, liver, kidney metabolic function. Conclusions: The hydro-ethanolic extract of Amaranthus spinosus has ischuretic activity possibly mediated via nicotinic, histaminic and muscarinic receptor stimulation and is safety to use in ischuria. [Int J Basic Clin Pharmacol 2013; 2(5.000: 517-527

  16. Preliminary study to improve the performance of SCWR-M during loss-of-flow accident

    Energy Technology Data Exchange (ETDEWEB)

    Liu, X.J., E-mail: xiaojingliu@sjtu.edu.cn [School of Nuclear Science and Engineering, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240 (China); Sun, C.; Wang, Z.D.; Chai, X.; Xiong, J.B.; Yang, Y.H. [School of Nuclear Science and Engineering, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240 (China); Cheng, X. [Institute of Fusion and Nuclear Technology, Karlsruhe Institute of Technology (KIT), Kaiserstr. 12, 76131 Karlsruhe (Germany)

    2016-10-15

    Highlights: • Validation of the ATHLET-SC code to the safety analysis for SCWR. • Loss of flow accident analysis for SCWR-M is performed. • The passive design parameter is optimized. • The optimized SCWR-M design shows a better safety performance. - Abstract: The SCWR-M is one of the conceptual core designs with mixed neutron spectrum (fast and thermal), which is developed at Shanghai Jiao Tong University. Some preliminary calculations of this new conceptual SCWR indicate the SCWR-M system gets better safety characteristics compared to other single spectrum supercritical water cooled reactors. Loss of flow accident (LOFA) is of particular importance among the abnormal events and accidents for SCWR-M. In order to perform the preliminary study to improve the current SCWR-M safety design, this paper presents the validation results of the ATHLET-SC code and optimization work for safety system design parameters of the ICS, ACC, GDCS based on LOFA analysis. The better performance of the optimized design parameters are demonstrated by comparison with the previous design.

  17. Study Abroad Programs: Making Safety a Priority

    Science.gov (United States)

    Buddan, Michael Craig; Budden, Connie B.; Juban, Rusty; Baraya, Aristides

    2014-01-01

    Increasingly, students are participating in study abroad programs. Such programs provide participants a variety of learning experiences. Developing cross-cultural appreciation, communication skills, maturity and a less ethno-centric mindset are among the impacts study abroad programs offer. However, care must be taken to assure student safety and…

  18. Railway safety climate: a study on organizational development.

    Science.gov (United States)

    Cheng, Yung-Hsiang

    2017-09-07

    The safety climate of an organization is considered a leading indicator of potential risk for railway organizations. This study adopts the perceptual measurement-individual attribute approach to investigate the safety climate of a railway organization. The railway safety climate attributes are evaluated from the perspective of railway system staff. We identify four safety climate dimensions from exploratory factor analysis, namely safety communication, safety training, safety management and subjectively evaluated safety performance. Analytical results indicate that the safety climate differs at vertical and horizontal organizational levels. This study contributes to the literature by providing empirical evidence of the multilevel safety climate in a railway organization, presents possible causes of the differences under various cultural contexts and differentiates between safety climate scales for diverse workgroups within the railway organization. This information can be used to improve the safety sustainability of railway organizations and to conduct safety supervisions for the government.

  19. A biogeographic study of intermountain leeches : Preliminary report

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Preliminary report for a five year study on leeches in the intermountain west. This work began out of curiosity to determine what, besides fishes, occurred in the...

  20. Preliminary Study of Realistic Blast Impact on Cultured Brain Slices

    Science.gov (United States)

    2015-04-01

    hippocampal slice samples to better understand blast-induced brain damage. 15. SUBJECT TERMS RDX spheres , organotypic cultures of hippocampus, small...Preliminary Study of Realistic Blast Impact on Cultured Brain Slices by Thuvan Piehler, Rohan Banton, Lars Piehler, Richard Benjamin, Ray...Aberdeen Proving Ground, MD 21005-5066 ARL-TR-7197 April 2015 Preliminary Study of Realistic Blast Impact on Cultured Brain Slices Thuvan

  1. Mixed Waste Management Facility Preliminary Safety Analysis Report. Chapters 1 to 20

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    This document provides information on waste management practices, occupational safety, and a site characterization of the Lawrence Livermore National Laboratory. A facility description, safety engineering analysis, mixed waste processing techniques, and auxiliary support systems are included.

  2. Preliminary safety assessment of C-8 xylitol monoester and xylitol phosphate esters.

    Science.gov (United States)

    Silveira, J E P S; Pereda, M C V; Nogueira, C; Dieamant, G; Cesar, C K M; Assanome, K M; Silva, M S; Torello, C O; Queiroz, M L S; Eberlin, S

    2016-02-01

    Most of the cosmetic compounds with preservative properties available in the market pose some risks concerning safety, such as the possibility of causing sensitization. Due to the fact that there are few options, the proper development of new molecules with this purpose is needed. Xylitol is a natural sugar, and the antimicrobial properties of xylitol-derived compounds have already been described in the literature. C-8 xylitol monoester and xylitol phosphate esters may be useful for the development of skincare products. As an initial screen for safety of chemicals, the combination of in silico methods and in vitro testing can aid in prioritizing resources in toxicological investigations while reducing the ethical and monetary costs that are related to animal and human testing. This study was designed to evaluate the safety of C-8 xylitol monoester and xylitol phosphate esters regarding carcinogenicity, mutagenicity, skin and eye irritation/corrosion and sensitization through alternative methods. For the initial safety assessment, quantitative structure-activity relationship methodology was used. The prediction of the parameters carcinogenicity/mutagenicity, skin and eye irritation/corrosion and sensitization was generated from the chemical structure. The analysis also comprised physical-chemical properties, Cramer rules, threshold of toxicological concern and Michael reaction. In silico results of candidate molecules were compared to 19 compounds with preservative properties that are available in the market. Additionally, in vitro tests (Ames test for mutagenicity, cytotoxicity and phototoxicity tests and hen's egg test--chorioallantoic membrane for irritation) were performed to complement the evaluation. In silico evaluation of both molecules presented no structural alerts related to eye and skin irritation, corrosion and sensitization, but some alerts for micronucleus and carcinogenicity were detected. However, by comparison, C-8 xylitol monoester, xylitol

  3. Measuring Safety Culture on Ships Using Safety Climate: A Study among Indian Officers

    Directory of Open Access Journals (Sweden)

    Yogendra Bhattacharya

    2015-12-01

    Full Text Available Workplace safety continues to be an area of concern in the maritime industry due to the international nature of the operations. The effectiveness of extensive legislation to manage shipboard safety remains in doubt. The focus must therefore shift towards the human element - seafarers and their perceptions of safety. The study aims to understand the alignment that exists between safety culture and safety climate on board ships as perceived by seafarers. The underlying factors of safety climate were identified using factor analysis which isolated seven factors - Support on Safety, Organizational Support, Resource Availability, Work Environment, Job Demands, ‘Just’ Culture, and Safety Compliance. The perception of safety level of seafarers was found to be low indicating the existence of misalignments between safety culture values and the actual safety climate. The study also reveals that the safety perceptions of officers employed directly by ship owners and those by managers do not differ significantly, nor do they differ between senior and junior officers. A shift in perspective towards how seafarers themselves feel towards safety might provide more effective solutions – instead of relying on regulations - and indeed aid in reducing incidents on board. This paper details practical suggestions on how to identify the factors that contribute towards a better safety climate on board ships.

  4. Preliminary studies of a new accelerator-driven minor actinide burner in industrial scale

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xunzhao; Zhou, Shengcheng [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049, Shaanxi (China); Zheng, Youqi, E-mail: yqzheng@mail.xjtu.edu.cn [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049, Shaanxi (China); Wang, Kunpeng [Nuclear and Radiation Safety Center, PO Box 8088, No. 54, Beijing 100082 (China); Wu, Hongchun [School of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049, Shaanxi (China)

    2015-10-15

    Highlights: • A new accelerator-driven minor actinide (MA) burner was proposed. • Comprehensive design of spallation target, fuel assembly and subcritical core was performed. • Preliminary safety analyses indicate the inherent safety of the core in the reactivity insertion (500 pcm) and beam overpower (50% increase) transients. - Abstract: Pursuing high transmutation rate of minor actinide (MA), a preliminary conceptual design of a lead-bismuth (LBE) cooled accelerator-driven system (ADS) is proposed in this study. Parametric studies are performed to optimize the neutronics and thermal–hydraulics performances. The proton energy and axial position of the proton beam impact is investigated to obtain high neutron source efficiency and spallation neutron yield. The influences of MA/Pu mixing ratio and the ratio of pin pitch to diameter (P/D) are also optimized to control the burnup reactivity swing and the minimum coolant velocity for adequate cooling. To reduce the power peak, three kinds of power flattening techniques are adopted and compared. The results show that the inert matrix ratio zone loading method seems more versatile. Based on the analyses, an optimized three zone loading pattern is proposed for the 800 MWth subcritical core. The total transmutation rate of MA is 328.8 kg per effective full power year. Preliminary safety analyses based on the balance of power method (BOP) are performed and the results show that in the reactivity insertion and beam overpower transients, the core shows inherent safety, but the scram is necessary by cutting off the beam current to protect the core from possible damages caused by the loss of flow.

  5. Pressure Safety: Advanced Self-Study 30120

    Energy Technology Data Exchange (ETDEWEB)

    Glass, George [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-29

    Pressure Safety Advance Self-Study (Course 30120) consists of an introduction, five modules, and a quiz. To receive credit in UTrain for completing this course, you must score 80% or better on the 15-question quiz (check UTrain). Directions for initiating the quiz are appended to the end of this training manual. This course contains several links to LANL websites. UTrain might not support active links, so please copy links into the address line in your browser.

  6. Teaching microbiological food safety through case studies

    OpenAIRE

    Florence Dubois-Brissonnet; Laurent Guillier; Murielle Naïtali

    2015-01-01

    Higher education students usually ask for more training based on case studies. This was addressed by designing a specific food safety module (24 hours) in which students were shown how to predict microbiological risks in food products i.e. they were asked to determine product shelf-life according to product formulation, preservation methods and consumption habits using predictive microbiology tools. Working groups of four students first identified the main microbiological hazards associated w...

  7. Undetected latent failures of safety-related systems. Preliminary survey of events in nuclear power plants 1980-1997

    Energy Technology Data Exchange (ETDEWEB)

    Lydell, B. [RSA Technologies, Vista, CA (United States)

    1998-03-01

    This report summarizes results and insights from a preliminary survey of events involving undetected, latent failures of safety-related systems. The survey was limited to events where mispositioned equipment (e.g., valves, switches) remained undetected, thus rendering standby equipment or systems unavailable for short or long time periods. Typically, these events were symptoms of underlying latent errors (e.g., design errors, procedure errors, unanalyzed safety conditions) and programmatic errors. The preliminary survey identified well over 300 events. Of these, 95 events are documented in this report. Events involving mispositioned equipment are commonplace. Most events are discovered soon after occurrence, however. But as evidenced by the survey results, some events remained undetected beyond several shift changes. The recommendations developed by the survey emphasize the importance of applying modern root cause analysis techniques to the event analysis to ensure that the causes and implications of occurred events are fully understood. 7 refs, 4 tabs, 3 figs. Also available at the SKI Home page: //www.ski.se.

  8. Modular endoprosthesis for mandibular reconstruction: a preliminary animal study.

    NARCIS (Netherlands)

    Lee, S.; Goh, B.T.; Tideman, H.; Stoelinga, P.J.W.

    2008-01-01

    The use of a mandibular modular endoprosthesis after segmental resection of part of the body of the mandible was studied. This preliminary study was carried out on four pigs and four monkeys. The devices were made of a titanium alloy and were cemented in the prepared medullary spaces with polymethyl

  9. Preliminary design study of underground pumped hydro and compressed-air energy storage in hard rock. Volume 1: Executive summary

    Science.gov (United States)

    1981-05-01

    A preliminary design study of water compensated Compressed Air Energy Storage (CAES) and Underground Pumped Hydroelectric (UPH) plants for siting in geological conditions suitable for hard rock excavations was performed. The study was divided into five primary tasks as follows: establishment of design criteria and analysis of impact on power system; selection of site and establishment of site characteristics; formulation of design approaches; assessment of environmental and safety aspects; and preparation of preliminary design of plant. The salient aspects considered and the conclusions reached during the consideration of the five primary tasks for both CAES and UPH are presented.

  10. Small Liquid Metal Cooled Reactor Safety Study

    Energy Technology Data Exchange (ETDEWEB)

    Minato, A; Ueda, N; Wade, D; Greenspan, E; Brown, N

    2005-11-02

    The Small Liquid Metal Cooled Reactor Safety Study documents results from activities conducted under Small Liquid Metal Fast Reactor Coordination Program (SLMFR-CP) Agreement, January 2004, between the Central Research Institute of the Electric Power Industry (CRIEPI) of Japan and the Lawrence Livermore National Laboratory (LLNL)[1]. Evaluations were completed on topics that are important to the safety of small sodium cooled and lead alloy cooled reactors. CRIEPI investigated approaches for evaluating postulated severe accidents using the CANIS computer code. The methods being developed are improvements on codes such as SAS 4A used in the US to analyze sodium cooled reactors and they depend on calibration using safety testing of metal fuel that has been completed in the TREAT facility. The 4S and the small lead cooled reactors in the US are being designed to preclude core disruption from all mechanistic scenarios, including selected unprotected transients. However, postulated core disruption is being evaluated to support the risk analysis. Argonne National Laboratory and the University of California Berkeley also supported LLNL with evaluation of cores with small positive void worth and core designs that would limit void worth. Assessments were also completed for lead cooled reactors in the following areas: (1) continuing operations with cladding failure, (2) large bubbles passing through the core and (3) recommendations concerning reflector control. The design approach used in the US emphasizes reducing the reactivity in the control mechanisms with core designs that have essentially no, or a very small, reactivity change over the core life. This leads to some positive void worth in the core that is not considered to be safety problem because of the inability to identify scenarios that would lead to voiding of lead. It is also believed that the void worth will not dominate the severe accident analysis. The approach used by 4S requires negative void worth throughout

  11. Preliminary comparison of efficacy and safety of dasatinib and imatinib in newly diagnosed chronic myeloid leukemia

    Institute of Scientific and Technical Information of China (English)

    周励

    2013-01-01

    Objective To compare the efficacy and safety of dasatinib and imatinib in patients with newly diagnosed chronic phase chronic myeloid leukemia(CML-CP).Methods37CML-CP patients were randomized to receive

  12. A Preliminary Survey of Risk and Safety Operations at Selected Universities,

    Science.gov (United States)

    1982-04-01

    S.C. RISK AND INSURANCE (B) Michigan State University RISK AND SAFETY MANAGEMENT (A) North Central Technical College, Ohio RISK MANAGEMENT AND...3440 Risk and Insurance BA 7417 Concepts in Risk and Insurance .............................................................................. NATIONAL

  13. Preliminary Assessment of Operational Hazards and Safety Requirements for Airborne Trajectory Management (ABTM) Roadmap Applications

    Science.gov (United States)

    Cotton, William B.; Hilb, Robert; Koczo, Stefan, Jr.; Wing, David J.

    2016-01-01

    A set of five developmental steps building from the NASA TASAR (Traffic Aware Strategic Aircrew Requests) concept are described, each providing incrementally more efficiency and capacity benefits to airspace system users and service providers, culminating in a Full Airborne Trajectory Management capability. For each of these steps, the incremental Operational Hazards and Safety Requirements are identified for later use in future formal safety assessments intended to lead to certification and operational approval of the equipment and the associated procedures. Two established safety assessment methodologies that are compliant with the FAA's Safety Management System were used leading to Failure Effects Classifications (FEC) for each of the steps. The most likely FEC for the first three steps, Basic TASAR, Digital TASAR, and 4D TASAR, is "No effect". For step four, Strategic Airborne Trajectory Management, the likely FEC is "Minor". For Full Airborne Trajectory Management (Step 5), the most likely FEC is "Major".

  14. A New Silver Complex with Ofloxacin – Preliminary Study

    Directory of Open Access Journals (Sweden)

    Rusu Aura

    2016-06-01

    Full Text Available Objective: Silver complexes of antibacterial quinolones have the potential advantage of combining the antibacterial activity of silver and fluoroquinolones. The objective of our study was the preparation and the preliminary physico-chemical characterization of a silver complex with ofloxacin.

  15. Preliminary Design Study of a Hybrid Airship for Flight Research

    Science.gov (United States)

    Browning, R. G. E.

    1981-01-01

    The feasibility of using components from four small helicopters and an airship envelope as the basis for a quad-rotor research aircraft was studied. Preliminary investigations included a review of candidate hardware and various combinations of rotor craft/airship configurations. A selected vehicle was analyzed to assess its structural and performance characteristics.

  16. Vertical infraclavicular brachial plexus block in children: a preliminary study.

    NARCIS (Netherlands)

    Jose Maria, B. de; Tielens, L.K.P.

    2004-01-01

    BACKGROUND: Brachial plexus blockade is a well-established technique in upper limb surgery. Among the infraclavicular approaches, the vertical infraclavicular brachial plexus (VIP) block is easy to perform and has a large spectrum of nerve blockade. The aim of this preliminary study was to determine

  17. Preliminary study on chicken feather protein-based wood adhesives

    Science.gov (United States)

    Zehui Jiang; Daochun Qin; Chung-Yun Hse; Monlin Kuo; Zhaohui Luo; Ge Wang; Yan Yu

    2008-01-01

    The objective of this preliminary study was to partially replace phenol in the synthesis of phenol-formaldehyde resin with feather protein. Feather protein–based resins, which contained one part feather protein and two parts phenol, were formulated under the conditions of two feather protein hydrolysis methods (with and without presence of phenol during...

  18. Preliminary study to AP mine neutralisation by EFP impact

    NARCIS (Netherlands)

    Meulman, J.H.

    2004-01-01

    A preliminary study has been conducted into the response of anti-personnel mines at the impact of an Explosively Formed Projectile (EFP). The objective was to obtain a low order reaction (preferably a deflagration) to minimise collateral damage. Further the method should be capable to neutralise min

  19. Advanced Burner Reactor Preliminary NEPA Data Study.

    Energy Technology Data Exchange (ETDEWEB)

    Briggs, L. L.; Cahalan, J. E.; Deitrich, L. W.; Fanning, T. H.; Grandy, C.; Kellogg, R.; Kim, T. K.; Yang, W. S.; Nuclear Engineering Division

    2007-10-15

    The Global Nuclear Energy Partnership (GNEP) is a new nuclear fuel cycle paradigm with the goals of expanding the use of nuclear power both domestically and internationally, addressing nuclear waste management concerns, and promoting nonproliferation. A key aspect of this program is fast reactor transmutation, in which transuranics recovered from light water reactor spent fuel are to be recycled to create fast reactor transmutation fuels. The benefits of these fuels are to be demonstrated in an Advanced Burner Reactor (ABR), which will provide a representative environment for recycle fuel testing, safety testing, and modern fast reactor design and safeguard features. Because the GNEP programs will require facilities which may have an impact upon the environment within the meaning of the National Environmental Policy Act of 1969 (NEPA), preparation of a Programmatic Environmental Impact Statement (PEIS) for GNEP is being undertaken by Tetra Tech, Inc. The PEIS will include a section on the ABR. In support of the PEIS, the Nuclear Engineering Division of Argonne National Laboratory has been asked to provide a description of the ABR alternative, including graphics, plus estimates of construction and operations data for an ABR plant. The compilation of this information is presented in the remainder of this report. Currently, DOE has started the process of engaging industry on the design of an Advanced Burner Reactor. Therefore, there is no specific, current, vendor-produced ABR design that could be used for this PEIS datacall package. In addition, candidate sites for the ABR vary widely as to available water, geography, etc. Therefore, ANL has based its estimates for construction and operations data largely on generalization of available information from existing plants and from the environmental report assembled for the Clinch River Breeder Reactor Plant (CRBRP) design [CRBRP, 1977]. The CRBRP environmental report was chosen as a resource because it thoroughly

  20. Preliminary safety analysis for key design features of KALIMER with breakeven core

    Energy Technology Data Exchange (ETDEWEB)

    Hahn, Do Hee; Kwon, Y. M.; Chang, W. P.; Suk, S. D.; Lee, Y. B.; Jeong, K. S

    2001-06-01

    KAERI is currently developing the conceptual design of a Liquid Metal Reactor, KALIMER (Korea Advanced Liquid MEtal Reactor) under the Long-term Nuclear R and D Program. KALIMER addresses key issues regarding future nuclear power plants such as plant safety, economics, proliferation, and waste. In this report, descriptions of safety design features and safety analyses results for selected ATWS accidents for the breakeven core KALIMER are presented. First, the basic approach to achieve the safety goal is introduced in Chapter 1, and the safety evaluation procedure for the KALIMER design is described in Chapter 2. It includes event selection, event categorization, description of design basis events, and beyond design basis events.In Chapter 3, results of inherent safety evaluations for the KALIMER conceptual design are presented. The KALIMER core and plant system are designed to assure benign performance during a selected set of events without either reactor control or protection system intervention. Safety analyses for the postulated anticipated transient without scram (ATWS) have been performed to investigate the KALIMER system response to the events. In Chapter 4, the design of the KALIMER containment dome and the results of its performance analyses are presented. The design of the existing containment and the KALIMER containment dome are compared in this chapter. Procedure of the containment performance analysis and the analysis results are described along with the accident scenario and source terms. Finally, a simple methodology is introduced to investigate the core energetics behavior during HCDA in Chapter 5. Sensitivity analyses have been performed for the KALIMER core behavior during super-prompt critical excursions, using mathematical formulations developed in the framework of the Modified Bethe-Tait method. Work energy potential was then calculated based on the isentropic fuel expansion model.

  1. Safety Study of Doxicycline in Broiler Chickens

    Directory of Open Access Journals (Sweden)

    Romeo Teodor Cristina

    2010-05-01

    Full Text Available Doxicycline is a structural isomer who meets the European reference standard (Ph.Eur. III 1997:0272 and respect EU Regulations for M.R.L. The good solubility permits high tissular absorption and distribution after administration in drinking water. The aim was to ascertain the clinical effects and tolerance consecutive to risen doses administration, as a part of safety study for this antibiotic in poultry in the respect of current drug testing methodology. The safety study revealed: good local and general tolerance to therapeutic doses (10 mg x kgb.w.-1 and to x2 dose, diarrhoea in lots which received x3 and x5 the therapeutic dose. Comparatively with the Control lot, haemoleucogram doesn’t suffer evident changes the registered values being between the references limits (exception of leucocitary formula. Also it was found an increased creatinin concentration consecutively to x3 and x5 greater doses administration and marked increasing of ASAT level and limited for ALAT’s, comparatively to control lot in the case of E4 lot, but light to reference values. Macro and microscopy revealed for the liver samples: hepatomegaly, diffuse hepatic degenerescence, nuclear heterochromatinization, vacuolar degenerescence; renal changes in nefrons and renal corpuscles, light splenomegaly, caecal sacs distension and brown-yellowish gaseous content to lots E3 and E4.

  2. Preliminary toxicological study of Irganox 1010

    Energy Technology Data Exchange (ETDEWEB)

    Drake, G.A.; London, J.E.; Smith, D.M.; Thomas, R.G.

    1979-10-01

    Acute oral LD/sub 50/30/ values for mice and rats receiving Irganox 1010 were found to be greater than 5 g/kg. According to classical guidelines, this material would be considered slightly toxic or practically nontoxic in both species. Skin applicaton studies in rabbits showed the material to be nonirritating. Eye irritation studies, also in the rabbit, showed that Irganox 1010 was a mild but transitory irritant. The sensitizaton study in guinea pigs did not show the material to be deleterious.

  3. Preliminary toxicological study of Silastic 386 catalyst

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.M.; Drake, G.A.; Holland, L.M.; Jackson, D.E.; London, J.E.; Prine, J.R.; Thomas, R.G.

    1978-06-01

    The calculated acute oral LD/sub 50//sup 30/ values for Silastic 386 catalyst were 1225 mg/kg in mice and 4350 mg/kg in rats. According to classical guidelines, the compound would be slightly to moderately toxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. The eye irritation study disclosed the compound to be a severe irritant causing conjunctivitis, photophobia, corneal edema, corneal ulceration, anterior uveitis, and keratitis. The sensitization study in the guinea pig did not show Silastic 386 catalyst to be deleterious in this regard.

  4. Preliminary experimental study of liquid lithium water interaction

    Energy Technology Data Exchange (ETDEWEB)

    You, X.M.; Tong, L.L.; Cao, X.W., E-mail: caoxuewu@sjtu.edu.cn

    2015-10-15

    Highlights: • Explosive reaction occurs when lithium temperature is over 300 °C. • The violence of liquid lithium water interaction increases with the initial temperature of liquid lithium. • The interaction is suppressed when the initial water temperature is above 70 °C. • Steam explosion is not ignorable in the risk assessment of liquid lithium water interaction. • Explosion strength of liquid lithium water interaction is evaluated by explosive yield. - Abstract: Liquid lithium is the best candidate for a material with low Z and low activation, and is one of the important choices for plasma facing materials in magnetic fusion devices. However, liquid lithium reacts violently with water under the conditions of loss of coolant accidents. The release of large heats and hydrogen could result in the dramatic increase of temperature and pressure. The lithium–water explosion has large effect on the safety of fusion devices, which is an important content for the safety assessment of fusion devices. As a preliminary investigation of liquid lithium water interaction, the test facility has been built and experiments have been conducted under different conditions. The initial temperature of lithium droplet ranged from 200 °C to 600 °C and water temperature was varied between 20 °C and 90 °C. Lithium droplets were released into the test section with excess water. The shape of lithium droplet and steam generated around the lithium were observed by the high speed camera. At the same time, the pressure and temperature in the test section were recorded during the violent interactions. The preliminary experimental results indicate that the initial temperature of lithium and water has an effect on the violence of liquid lithium water interaction.

  5. Preliminary assessment of a combined passive safety system for typical 3-loop PWR CPR1000

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zijiang; Shan, Jianqiang, E-mail: jqshan@mail.xjtu.edu.cn; Gou, Junli

    2017-03-15

    Highlights: • A combined passive safety system was placed on a typical 3-loop PWR CPR1000. • Three accident analyses show the three different accident mitigation methods of the passive safety system. • The three mitigation methods were proved to be useful. - Abstract: As the development of the nuclear industry, passive technology turns out to be a remarkable characteristic of advanced nuclear power plants. Since the 20th century, much effort has been given to the passive technology, and a number of evolutionary passive systems have developed. Thoughts have been given to upgrade the existing reactors with passive systems to meet stricter safety demands. In this paper, the CPR1000 plant, which is one kind of mature pressurized water reactor plants in China, is improved with some passive systems to enhance safety. The passive systems selected are as follows: (1) the reactor makeup tank (RMT); (2) the advanced accumulator (A-ACC); (3) the in-containment refueling water storage tank (IRWST); (4) the passive emergency feed water system (PEFS), which is installed on the secondary side of SGs; (5) the passive depressurization system (PDS). Although these passive components is based on the passive technology of some advanced reactors, their structural and trip designs are adjusted specifically so that it could be able to mitigate accidents of the CPR1000. Utilizing the RELAP5/MOD3.3 code, accident analyses (small break loss of coolant accident, large break loss of coolant accident, main feed water line break accident) of this improved CPR1000 plant were presented to demonstrate three different accident mitigation methods of the safety system and to test whether the passive safety system preformed its function well. In the SBLOCA, all components of the passive safety system were put into work sequentially, which prevented the core uncover. The LBLOCA analysis illustrates the contribution of the A-ACCs whose small-flow-rate injection can control the maximum cladding

  6. Diesel engine emission deterioration - a preliminary study

    CSIR Research Space (South Africa)

    Pretorius, Cecilia J

    2016-04-01

    Full Text Available The objective of this study was to find a parameter in diesel and oil analysis of underground mining vehicles that can be correlated with personal diesel particulate matter (DPM) exposure and used as part of an engine maintenance programme. A number...

  7. Preliminary study of pur-revetment's application

    NARCIS (Netherlands)

    Gu, D.; Verhagen, H.J.; Van de Ven, M.

    2008-01-01

    PUR-revetment is a newly developed method for hydraulic application. Its structure is similar to that of open stone asphalt revetment, but the crushed stones are glued by polyurethane (PUR) instead of bitumen. To study the feasibility of applying PUR-revetment, a research based on the comparisons be

  8. Caregivers with Visual Impairments: A Preliminary Study

    Science.gov (United States)

    Fuhr, Patti; Martinez, Bethany; Williams, Michael

    2008-01-01

    Persons who are elderly, visually impaired, and primary caregivers for ailing or disabled spouses or significant others are a unique population that has not been studied previously. By definition, "informal caregivers" are family members or friends who provide unpaid day-to-day assistance with activities of daily living and are familiar with the…

  9. Preliminary Study of Performance of TTA Resin

    Institute of Scientific and Technical Information of China (English)

    HUANG; Kun; MAO; Guo-shu

    2013-01-01

    TTA(thenoyl trifluoroacetone)extraction can effectively remove large amounts of uranium in the analysis of trace neptunium in the presence of large amounts of uranium.While it is not conducive to achieve the automation of the rapid analysis of neptunium with the TTA solution,the TTA resin was prepared and its properties were studied in this work.TTA resin in this work was a kind of mixture combining styrene-divinylbenzene skeleton with TTA

  10. Microwave Influence in Fungi a Preliminary Study

    Energy Technology Data Exchange (ETDEWEB)

    Manoliu, A. I.; Tufescu, F. M.; Oprica, L.; Olteanu, Z.; Creanga, D. E.

    2004-07-01

    The behavior of two cellulolytic fungus species under the influence of low intensity microwaves was studied: Chaetomium globosum and Alternaria alternata. Enzyme activity of dehydrogenase complex was investigated by spectrophotometric method in order to real the effect of relatively short daily exposure times. Inhibitory effect was noticed for malate dehydrogenase and succinate dehydrogenase in both fungi while differentiated influence was revealed in alpha ceto glutarate dehydrogenase (inhibitory in Chaetomium globosum but stimulatory in Alternaria alternata). Isocitrate dehydrogenase activity was significantly stimulated in both fungi for 3 hours exposure time. (Author) 15 refs.

  11. [Preliminary study on the pharmacological action spicatus].

    Science.gov (United States)

    Gai, H; Shou, Y; Wang, J; Li, L

    1997-01-01

    In this report the pharmacological action of Spicatus was studied. The results insicated that it had diureric, antibiotic and anti-inflammatory effects, yet had Iittle toxic side-effect. It had significant inhibitory effect on crofon oil-caused mice ear swell. It also had marked diuretic effect in orcinary rats, but had Iittie effect on uric pH the rats. It exhibited certain inhibition of Staphycoloccus aureus, Eschrichia coli and Pseudomonas aeruginosa in vitro. The maximum tolerable dose test in mice showed no marked toxic effect, LD50 > 80 g/kg.

  12. Preliminary Study on the High Efficiency Supercritical Pressure Water-Cooled Reactor for Electricity Generation

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Yoon Yeong; Park, Jong Kyun; Cho, Bong Hyun and others

    2006-01-15

    This research has been performed to introduce a concept of supercritical pressure water cooled reactor(SCWR) in Korea The area of research includes core conceptual design, evaluation of candidate fuel, fluid systems conceptual design with mechanical consideration, preparation of safety analysis code, and construction of supercritical pressure heat transfer test facility, SPHINX, and preliminary test. As a result of the research, a set of tools for the reactor core design has been developed and the conceptual core design with solid moderator was proposed. The direct thermodynamic cycle has been studied to find a optimum design. The safety analysis code has also been adapted to supercritical pressure condition. A supercritical pressure CO2 heat transfer test facility has been constructed and preliminary test proved the facility works as expected. The result of this project will be good basis for the participation in the international collaboration under GIF GEN-IV program and next 5-year mid and long term nuclear research program of MOST. The heat transfer test loop, SPHINX, completed as a result of this project may be used for the power cycle study as well as further heat transfer study for the various geometries.

  13. A preliminary ultrasound study of velar fronting

    Science.gov (United States)

    Wodzinski, Sylvie M.; Frisch, Stefan A.

    2003-10-01

    The purpose of this study is to (1) evaluate the effectiveness of ultrasound imaging to measure velar consonant closure location, and (2) conduct a thorough study of velar fronting by measuring several productions of velar stops in the context of every English vowel. Word onset velar stops were measured in both words (CV or CVC) and nonwords (VCV) within a carrier phrase. Other coarticulatory influences were minimized by using words with no coda or labial coda consonants (e.g., ``Say a gap again,'' ``Say /oIkoI/ again''). Measurements were made at the point of maximal closure. Closure location was measured using the radial angle from the center of the ultrasound probe to the center of the velar closure. Pilot data for one subject has been analyzed to date. Closure location appears consistent across all central and back vowels. For front vowels, the degree of fronting of the velar appears to be correlated with the frontness of the vowel. Measures of closure location for diphthongs followed the back vowel pattern in the word targets. For nonwords, the closure location was influenced by the preceding diphthong offset quality and the following diphthong onset quality. Theoretical implications for the phonetics/phonology interface will be discussed.

  14. Teaching microbiological food safety through case studies

    Directory of Open Access Journals (Sweden)

    Florence Dubois-Brissonnet

    2015-10-01

    Full Text Available Higher education students usually ask for more training based on case studies. This was addressed by designing a specific food safety module (24 hours in which students were shown how to predict microbiological risks in food products i.e. they were asked to determine product shelf-life according to product formulation, preservation methods and consumption habits using predictive microbiology tools. Working groups of four students first identified the main microbiological hazards associated with a specific product. To perform this task, they were given several documents including guides for good hygiene practices, reviews on microbiological hazards in the food sector, flow sheets, etc…  After three-hours of work, the working groups prepared and gave an oral presentation in front of their classmates and professors. This raised comments and discussion that allowed students to adjust their conclusions before beginning the next step of their work. This second step consisted in the evaluation of the safety risk associated with the two major microbiological hazards of the product studied, using predictive microbiology. Students then attended a general lecture on the different tools of predictive microbiology and tutorials (6 hours that made them familiar with the modelling of bacterial growth or inactivation. They applied these tools (9 hours to predict the shelf-life of the studied product according to various scenarios of preservation (refrigeration, water activity, concentration of salt or acid, modified atmosphere, etc… and/or consumption procedures (cooking. The module was concluded by oral presentations of each working group and included student evaluation (3 hours.

  15. Preliminary study of disc hydrodynamic polishing.

    Science.gov (United States)

    Li, Yan; Lin, Bin; Zhang, XiaoFeng; Liu, PengFei

    2016-10-01

    In this paper, a developed polishing method based on elastic emission machining and Jules Verne-a variation on fluid jet polishing-is presented. This method is named disc hydrodynamic polishing (DHDP). A computational fluid dynamics (CFD)-based model that consists of a CFD model and an erosion model is introduced to predict the surface roughness obtained by DHDP. The performance of DHDP is studied by experiments. The slurry used in the experiments comprises 95% deionized water and 5% cerium oxide particles. Fused-silica glass is chosen as the workpiece. After the experiments, an ultrasmooth surface without cracks is obtained. The simulation results principally coincide with the experimental results. The experimental results show that the actual roughness is slightly less than the prediction and smaller particles are more favorable for obtaining a better surface roughness.

  16. A Preliminary Study of Fake Fingerprints

    Directory of Open Access Journals (Sweden)

    Qinghai Gao

    2014-11-01

    Full Text Available Fingerprint is a widely used biometrics. Its extensive usage motivates imposter to fabricate fake fingerprints. Vitality detection has been proposed to prevent counterfeit finger attack. Currently the detection can be done either during the process of acquiring fingerprint image or by comparing multiple sequentially acquired images. It is an ongoing research problem to detect whether a given fingerprint image is obtained from a real or a fake fingertip. In this paper we look into the differences between real and fake fingerprints as the first step to approach this problem. Specifically, we study the effects of different imaging sensors on the sizes of templates and on the matching scores between real and fake fingerprints. We also compare the fake fingerprints made from different materials. Experiments are carried out with two publicly available fingerprint databases and the findings are reported.

  17. Helicopter pilot back pain: a preliminary study.

    Science.gov (United States)

    Shanahan, D F; Reading, T E

    1984-02-01

    Because of the high prevalence of back pain experienced by U.S. Army helicopter pilots, a study was conducted to ascertain the feasibility of reproducing these symptoms in the laboratory. A mock-up of a UH-1H seat and control configuration was mounted to a multi-axis vibration simulator (MAVS). Eleven subjects were tested on the apparatus for two 120-min periods. During one period, the MAVS was programmed to reproduce vibrations recorded from a UH-1H in cruise flight. The subjects received no vibration during the other test period. All subjects reported back pain which they described as identical to the pain they experience during flight, during one or more of their test periods. There was no statistical difference between the vibration and nonvibration test conditions (p greater than 0.05) in terms of time of onset of pain or intensity of pain as measured by a visual analog scale. It appears the vibration at the frequencies and amplitudes tested plays little or no role in the etiology of the back symptoms reported by these pilots. It is proposed that the primary etiological factor for these symptoms is the poor posture pilots are obliged to assume for extended periods while operating helicopters.

  18. Improving patient safety culture in general practice: An interview study

    NARCIS (Netherlands)

    N.J. Verbakel (Natasha J.); A.A. de Bont (Antoinette); T.J. Verheij; C. Wagner (Cordula); D.L.M. Zwart (Dorien Lyd Marieke)

    2015-01-01

    textabstractBackground When improving patient safety a positive safety culture is key. As little is known about improving patient safety culture in primary care, this study examined whether administering a culture questionnaire with or without a complementary workshop could be used as an interventio

  19. Preliminary systems-interaction results from the Digraph Matrix Analysis of the Watts Bar Nuclear Power Plant safety-injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, I.J.; Ashmore, B.C.; Champney, J.M.; Alesso, H.P.

    1983-06-01

    This report provides preliminary results generated by a Digraph Matrix Analysis (DMA) for a Systems Interaction analysis performed on the Safety Injection System of the Tennessee Valley Authority Watts Bar Nuclear Power Plant. An overview of DMA is provided along with a brief description of the computer codes used in DMA.

  20. Preliminary systems-interaction results from the Digraph Matrix Analysis of the Watts Bar Nuclear Power Plant safety-injection systems

    Energy Technology Data Exchange (ETDEWEB)

    Sacks, I.J.; Ashmore, B.C.; Champney, J.M.; Alesso, H.P.

    1983-06-01

    This report provides preliminary results generated by a Digraph Matrix Analysis (DMA) for a Systems Interaction analysis performed on the Safety Injection System of the Tennessee Valley Authority Watts Bar Nuclear Power Plant. An overview of DMA is provided along with a brief description of the computer codes used in DMA.

  1. A preliminary safety analysis for the prototype Gen IV Sodium-Cooled Fast Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kwi Lim; Ha, Kwi Seok; Jeong, Jae Ho; Choi, Chi Woong; Jeong, Tae Kyeong; Ahn, Sang June; Lee, Seung Won; Chang, Won Pyo; Kang, Seok Hun; Yoo, Jae Woon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Korea Atomic Energy Research Institute has been developing a pool-type sodium-cooled fast reactor of the Prototype Gen-IV Sodium-cooled Fast Reactor (PGSFR). To assess the effectiveness of the inherent safety features of the PGSFR, the system transients during design basis accidents and design extended conditions are analyzed with MARS-LMR and the subchannel blockage events are analyzed with MATRA-LMR-FB. In addition, the in-vessel source term is calculated based on the super-safe, small, and simple reactor methodology. The results show that the PGSFR meets safety acceptance criteria with a sufficient margin during the events and keeps accidents from deteriorating into more severe accidents.

  2. Health and safety. Preliminary comparative assessment of the satellite power system (SPS) and other energy alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Habegger, L.J.; Gasper, J.R.; Brown, C.D.

    1980-04-01

    Existing data on the health and safety risks of a satellite power system and four electrical generation systems are analyzed: a combined-cycle coal power system with a low-Btu gasifier and open-cycle gas turbine, a fission power system with fuel reprocessing, a central-station, terrestrial, solar-photovoltaic power system, and a first-generation design for a fusion power system. The systems are compared on the basis of expected deaths and person-days lost per year associated with 1000 MW of average electricity generation and the number of health and safety risks that are identified as potentially significant but unquantifiable. The appendices provide more detailed information on risks, uncertainties, additional research needed, and references for the identified impacts of each system.

  3. Human Factors engineering criteria and design for the Hanford Waste Vitrification Plant preliminary safety analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Wise, J.A.; Schur, A.; Stitzel, J.C.L.

    1993-09-01

    This report provides a rationale and systematic methodology for bringing Human Factors into the safety design and operations of the Hanford Waste Vitrification Plant (HWVP). Human Factors focuses on how people perform work with tools and machine systems in designed settings. When the design of machine systems and settings take into account the capabilities and limitations of the individuals who use them, human performance can be enhanced while protecting against susceptibility to human error. The inclusion of Human Factors in the safety design of the HWVP is an essential ingredient to safe operation of the facility. The HWVP is a new construction, nonreactor nuclear facility designed to process radioactive wastes held in underground storage tanks into glass logs for permanent disposal. Its design and mission offer new opposites for implementing Human Factors while requiring some means for ensuring that the Human Factors assessments are sound, comprehensive, and appropriately directed.

  4. Health and safety: Preliminary comparative assessment of the Satellite Power System (SPS) and other energy alternatives

    Science.gov (United States)

    Habegger, L. J.; Gasper, J. R.; Brown, C.

    1980-01-01

    Data readily available from the literature were used to make an initial comparison of the health and safety risks of a fission power system with fuel reprocessing; a combined-cycle coal power system with a low-Btu gasifier and open-cycle gas turbine; a central-station, terrestrial, solar photovoltaic power system; the satellite power system; and a first-generation fusion system. The assessment approach consists of the identification of health and safety issues in each phase of the energy cycle from raw material extraction through electrical generation, waste disposal, and system deactivation; quantitative or qualitative evaluation of impact severity; and the rating of each issue with regard to known or potential impact level and level of uncertainty.

  5. Esophageal clearance scintigraphy in, diabetic patients; A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Karayalcin, B.; Karayalcin, U.; Aburano, Tamio; Nakajima, Kenichi; Hisada, Kinichi; Morise, Toshio; Okada, Toshihide; Takeda, Ryoyu (Kanazawa Univ. (Japan). School of Medicine)

    1992-05-01

    The aim of this preliminary study was to evaluate the predictive value of esophageal clearance scintigraphy (ECS) in the diagnosis of esophageal autonomic neuropathy in diabetic patients without any esophageal symptoms. A single swallon ECS was performed in 12 diabetic patients and 15 normal volunteers, and esophageal transit time (ETT) and esophageal (Es) T 1/2 values were calculated. ETT and Es 1/2 were found to be significantly prolonged in the diabetic group (p<0.01 and p<0.05, respectively). In this preliminary study, our results strongly suggest that ECS may be an important noninvasive diagnostic tool in the evaluation of diabetic patients with asymptomatic esophageal autonomic neuropathy. (author).

  6. Deproteinated palm kernel cake-derived oligosaccharides: A preliminary study

    Science.gov (United States)

    Fan, Suet Pin; Chia, Chin Hua; Fang, Zhen; Zakaria, Sarani; Chee, Kah Leong

    2014-09-01

    Preliminary study on microwave-assisted hydrolysis of deproteinated palm kernel cake (DPKC) to produce oligosaccharides using succinic acid was performed. Three important factors, i.e., temperature, acid concentration and reaction time, were selected to carry out the hydrolysis processes. Results showed that the highest yield of DPKC-derived oligosaccharides can be obtained at a parameter 170 °C, 0.2 N SA and 20 min of reaction time.

  7. Safety studies on Korean fusion DEMO plant using Integrated Safety Assessment Methodology: Part 2

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Kyemin; Kang, Myoung-suk [Kyung Hee University, Yongin-si, Gyeonggi-do 446-701 (Korea, Republic of); Heo, Gyunyoung, E-mail: gheo@khu.ac.kr [Kyung Hee University, Yongin-si, Gyeonggi-do 446-701 (Korea, Republic of); Kim, Hyoung-chan [National Fusion Research Institute, Daejeon-si 305-333 (Korea, Republic of)

    2015-10-15

    Highlights: • The purpose of this paper is to suggest methodology that can investigate safety issues and provides a case study for Korean fusion DEMO plant. • The concepts of Integrated Safety Assessment Methodology (ISAM) that can be applied in addressing regulatory requirements and recognizing safety issues for K-DEMO were emphasized. • Phenomena Identification Ranking Table (PIRT) and Objective Provision Tree (OPT) were performed and updated. • This work is expected to contribute on the conceptual design of safety features for K-DEMO to design engineers and the guidance for regulatory requirements to licensers. - Abstract: The purpose of this paper is to investigate safety issues using Integrated Safety Assessment Methodology (ISAM) proposed by Generation IV Forum Risk and Safety Working Group (RSWG) for Korean fusion DEMO plant (K-DEMO). In ongoing nuclear energy research such as Generation IV fission power plant (GEN-IV), new methodology based on Technology-Neutral Framework (TNF) has been applied for safety assessment. In this methodology, design and regulatory requirements for safety of nuclear power plants are considered simultaneously. The design based on regulatory requirements can save resource, time, and manpower while maintaining high level safety. ISAM is one of the options to apply TNF in K-DEMO. We have performed safety studies for K-DEMO using Phenomena Identification and Ranking Table (PIRT) and Objective Provision Tree (OPT) which are constitutive part of ISAM. Considering the design phase of K-DEMO, the current study focused on PIRT and OPT for K-DEMO. Results have been reviewed and updated by Korean fusion advisory group after considering the views of specialists from domestic universities, industries, and national institutes in South Korea.

  8. Tree STEM Reconstruction Using Vertical Fisheye Images: a Preliminary Study

    Science.gov (United States)

    Berveglieri, A.; Tommaselli, A. M. G.

    2016-06-01

    A preliminary study was conducted to assess a tree stem reconstruction technique with panoramic images taken with fisheye lenses. The concept is similar to the Structure from Motion (SfM) technique, but the acquisition and data preparation rely on fisheye cameras to generate a vertical image sequence with height variations of the camera station. Each vertical image is rectified to four vertical planes, producing horizontal lateral views. The stems in the lateral view are rectified to the same scale in the image sequence to facilitate image matching. Using bundle adjustment, the stems are reconstructed, enabling later measurement and extraction of several attributes. The 3D reconstruction was performed with the proposed technique and compared with SfM. The preliminary results showed that the stems were correctly reconstructed by using the lateral virtual images generated from the vertical fisheye images and with the advantage of using fewer images and taken from one single station.

  9. TREE STEM RECONSTRUCTION USING VERTICAL FISHEYE IMAGES: A PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    A. Berveglieri

    2016-06-01

    Full Text Available A preliminary study was conducted to assess a tree stem reconstruction technique with panoramic images taken with fisheye lenses. The concept is similar to the Structure from Motion (SfM technique, but the acquisition and data preparation rely on fisheye cameras to generate a vertical image sequence with height variations of the camera station. Each vertical image is rectified to four vertical planes, producing horizontal lateral views. The stems in the lateral view are rectified to the same scale in the image sequence to facilitate image matching. Using bundle adjustment, the stems are reconstructed, enabling later measurement and extraction of several attributes. The 3D reconstruction was performed with the proposed technique and compared with SfM. The preliminary results showed that the stems were correctly reconstructed by using the lateral virtual images generated from the vertical fisheye images and with the advantage of using fewer images and taken from one single station.

  10. SAFETY

    CERN Document Server

    Niels Dupont

    2013-01-01

    CERN Safety rules and Radiation Protection at CMS The CERN Safety rules are defined by the Occupational Health & Safety and Environmental Protection Unit (HSE Unit), CERN’s institutional authority and central Safety organ attached to the Director General. In particular the Radiation Protection group (DGS-RP1) ensures that personnel on the CERN sites and the public are protected from potentially harmful effects of ionising radiation linked to CERN activities. The RP Group fulfils its mandate in collaboration with the CERN departments owning or operating sources of ionising radiation and having the responsibility for Radiation Safety of these sources. The specific responsibilities concerning "Radiation Safety" and "Radiation Protection" are delegated as follows: Radiation Safety is the responsibility of every CERN Department owning radiation sources or using radiation sources put at its disposition. These Departments are in charge of implementing the requi...

  11. Preliminary safety analysis for offgas treatment system of DUPIC fuel manufacturing process at DFDF

    Energy Technology Data Exchange (ETDEWEB)

    Shin, J. M.; Lee, H. H.; Park, J. J.; Yang, M. S

    2000-09-01

    DUPIC fuel fabrication process is a dry processing technology to manufacture CANDU compatible fuel through a direct refabrication process from spent PWR fuel. DUPIC fuel fabrication process consists of the slitting of the spent PWR fuel rods, OREOX processing, homogeneous mixing, pelletizing and sintering. All these processes should be conducted by remote means in a M6 hot cell at IMEF. Since there is a lot of highly radioactive spent fuel(200 kg) to be used in DUPIC fuel fabrication process, safety analysis on DFDF facility is very important to improve the safety of hot cell and to reduce the dose exposure to operator. This report describes the design of IMEF facility, manufacturing equipment and process, offgas treatment system necessary for DUPIC fuel manufacturing process. Also, it provides the flow chart of arising and activity for each nuclide in offgas treatment system and final arising and activity for gaseous waste discharged from offgas treatment equipment into inside of M6 cell during OREOX and sintering processes in DUPIC fuel manufacturing process.

  12. Preliminary safety analysis report for the Auxiliary Hot Cell Facility, Sandia National Laboratories, Albuquerque, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    OSCAR,DEBBY S.; WALKER,SHARON ANN; HUNTER,REGINA LEE; WALKER,CHERYL A.

    1999-12-01

    The Auxiliary Hot Cell Facility (AHCF) at Sandia National Laboratories, New Mexico (SNL/NM) will be a Hazard Category 3 nuclear facility used to characterize, treat, and repackage radioactive and mixed material and waste for reuse, recycling, or ultimate disposal. A significant upgrade to a previous facility, the Temporary Hot Cell, will be implemented to perform this mission. The following major features will be added: a permanent shield wall; eight floor silos; new roof portals in the hot-cell roof; an upgraded ventilation system; and upgraded hot-cell jib crane; and video cameras to record operations and facilitate remote-handled operations. No safety-class systems, structures, and components will be present in the AHCF. There will be five safety-significant SSCs: hot cell structure, permanent shield wall, shield plugs, ventilation system, and HEPA filters. The type and quantity of radionuclides that could be located in the AHCF are defined primarily by SNL/NM's legacy materials, which include radioactive, transuranic, and mixed waste. The risk to the public or the environment presented by the AHCF is minor due to the inventory limitations of the Hazard Category 3 classification. Potential doses at the exclusion boundary are well below the evaluation guidelines of 25 rem. Potential for worker exposure is limited by the passive design features incorporated in the AHCF and by SNL's radiation protection program. There is no potential for exposure of the public to chemical hazards above the Emergency Response Protection Guidelines Level 2.

  13. Deep repository for long-lived low and intermediate-level waste. A preliminary safety assessment; Djupfoervar for laanglivat laag- och medelaktivt avfall. Preliminaer saekerhetsanalys

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-01

    A preliminary safety assessment has been performed of a deep repository for long-lived low and intermediate-level waste, SFL 3-5. The purpose of the study is to investigate the capacity of the facility to act as a barrier to the release of radionuclides and toxic pollutants, and to shed light on the importance of the location of the repository site. A safety assessment (SR 97) of a deep repository for spent fuel has been carried out at the same time. In SR 97, three hypothetical repository sites have been selected for study. These sites exhibit fairly different conditions in terms of hydrogeology, hydrochemistry and ecosystems. To make use of information and data from the SR 97 study, we have assumed that SFL 3-5 is co-sited with the deep repository for spent fuel. A conceivable alternative is to site SFL 3-5 as a completely separate repository. The focus of the SFL 3-5 study is a quantitative analysis of the environmental impact for a reference scenario, while other scenarios are discussed and analyzed in more general terms. Migration in the repository's near- and far-field has been taken into account in the reference scenario. Environmental impact on the three sites has also been calculated. The calculations are based on an updated forecast of the waste to be disposed of in SFL 3-5. The forecast includes radionuclide content, toxic metals and other substances that have a bearing on a safety assessment. The safety assessment shows how important the site is for safety. Two factors stand out as being particularly important: the water flow at the depth in the rock where the repository is built, and the ecosystem in the areas on the ground surface where releases may take place in the future. Another conclusion is that radionuclides that are highly mobile and long-lived, such as {sup 36}Cl and {sup 93}Mo, are important to be taken into consideration. Their being long-lived means that barriers and the ecosystems must be regarded with a very long time horizon.

  14. Online gaming dependency: a preliminary study in China.

    Science.gov (United States)

    Peng, Wei; Liu, Ming

    2010-06-01

    Based on theories and previous studies on problematic Internet use, we propose a model to better understand the contributors to and consequences of online gaming dependency. A preliminary study was conducted through a survey of online gamers in China. The results of path analysis found that maladaptive cognitions, shyness, and depression are positively related to online gaming dependency. Online gaming dependency was also positively related to different types of negative life outcomes. The findings of this study have implications for the prevention and treatment of addictive online gaming.

  15. Safety studies on Korean fusion DEMO plant using integrated safety assessment methodology

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Kyemin; Kang, Myoung-suk [Kyung Hee University, Youngin-si, Gyeonggi-do 446-701 (Korea, Republic of); Heo, Gyunyoung, E-mail: gheo@khu.ac.kr [Kyung Hee University, Youngin-si, Gyeonggi-do 446-701 (Korea, Republic of); Kim, Hyoung-chan [National Fusion Research Institute, Daejeon-si 305-333 (Korea, Republic of)

    2014-10-15

    Highlights: •The purpose of this paper is to suggest methodology that can investigate safety issues and provides a case study for Korean fusion DEMO plant. •The concepts of integrated safety assessment methodology (ISAM) that can be applied in addressing regulatory requirements and recognizing safety issues for K-DEMO were emphasized. •Phenomena identification and ranking table (PIRT) was proposed. It can recognize vulnerabilities of systems and identify the gaps in technical areas requiring additional researches. •This work is expected to contribute on the conceptual design of safety features for K-DEMO to design engineers and the guidance for regulatory requirements to licensers. -- Abstract: The purpose of this paper is to suggest methodology that can investigate safety issues and provides a case study for Korean fusion DEMO plant (K-DEMO) as a part of R and D program through the National Fusion Research Institute of Korea. Even though nuclear regulation and licensing framework is well setup due to the operating and design experience of Pressurized Water Reactors (PWRs) since 1970s, the regulatory authority of South Korea has concerns on the challenge of facing new nuclear facilities including K-DEMO due to the differences in systems, materials, and inherent safety feature from conventional PWRs. Even though the follow-up of the ITER license process facilitates to deal with significant safety issues of fusion facilities, a licensee as well as a licenser should identify the gaps between ITER and DEMO in terms of safety issues. First we reviewed the methods of conducting safety analysis for unprecedented nuclear facilities such as Generation IV reactors, particularly very high temperature reactor (VHTR), which is called as integrated safety assessment methodology (ISAM). Second, the analysis for the conceptual design of K-DEMO on the basis of ISAM was conducted. The ISAM consists of five analytical tools to develop the safety requirements from licensee

  16. Preliminary Observations on Safety of Children Whose Mother Use Depomedroxyprogesterone Acetate During Lactation in China

    Institute of Scientific and Technical Information of China (English)

    赵小菲; 雷贞武; 袁晓蓉; 杜桂来; 李梅; 赵玉琼; 刘光海; 吴尚纯

    2001-01-01

    Objective To investigate the safety of the children breast-fed by the mothers receiving depot medroxyprogesterone acetate (DMPA) during lactation Methods A total of 180 children were divided into two groups. The children in the experimental group (n= 90) included those whose mothers were given DMPA injection during lactation while mothers of the children in the control group (n = 90), at the same time, did not use DMPA. The body weight, height, head circumference, chest circumference, sitting-height, intelligence and behavioral adaptation of children in the two groups were measured and compared.Results There were no significant differences (P> 0. 05) in the body weight, height,head circumference, chest circumference, sitting-height, intelligence and behavioral in two groups.Conclusion DMPA can be safely used in breast-feeding women without harmful effects on physical and intellectual developments and behavioral adaptation of their offspring.

  17. Posiva's application for a decision in principle concerning a disposal facility for spent nuclear fuel. STUK's statement and preliminary safety appraisal

    Energy Technology Data Exchange (ETDEWEB)

    Ruokola, E. [ed.

    2000-03-01

    In May 1999, Posiva Ltd submitted to the Government an application, pursuant to the Nuclear Energy Act, for a Decision in Principle on a disposal facility for spent nuclear fuel from the Finnish nuclear power plants. The Ministry of Trade and Industry requested the Radiation and Nuclear Safety Authority (STUK) to draw up a preliminary safety appraisal concerning the proposed disposal facility. In the beginning of this report, STUK's statement to the Ministry and Industry concerning the proposed disposal facility is given. In that statement, STUK concludes that the Decision in Principle is currently justified from the standpoint of safety. The statement is followed by a safety appraisal, where STUK deems, how the proposed disposal concept, site and facility comply with the safety requirements included in the Government's Decision (478/1999). STUK's preliminary safety appraisal was supported by contributions from a number of outside experts. A collective opinion by an international group of ten distinguished experts is appended to this report. (orig.)

  18. Modeling and Testing of EVs - Preliminary Study and Laboratory Development

    DEFF Research Database (Denmark)

    Yang, Guang-Ya; Marra, Francesco; Nielsen, Arne Hejde

    2010-01-01

    impact at different geographical areas, as well as driving and charging patterns. Electric circuit model is deployed in this work to represent the electrical properties of a lithium-ion battery. This paper reports the preliminary modeling and validation work based on manufacturer data sheet and realistic......Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... tests, followed by the suggestions towards a feasible battery model for further studies....

  19. Photodynamic therapy of port wine stain: preliminary clinical studies

    Science.gov (United States)

    Nelson, J. Stuart

    1993-07-01

    The broad, long term objective of this work is the development of Photodynamic Therapy (PDT) for application in the clinical management of patients with port wine stain (PWS). PDT involves the use of an exogenous drug which is concentrated in a targeted tissue. When irradiated at wavelengths specifically absorbed by the drug, selective destruction of the targeted tissue, without the production of heat, occurs. The results of this preliminary study demonstrate in human PWS patients that a photosensitizer, such as PHOTOFRINR, activated by red light at the appropriate therapeutic wavelength, can cause destruction of subsurface blood vessels in the skin with a high degree of specificity, and further study appears warranted.

  20. Safety

    CERN Multimedia

    2003-01-01

    Please note that the safety codes A9, A10 AND A11 (ex annexes of SAPOCO/42) entitled respectively "Safety responsibilities in the divisions" "The safety policy committee (SAPOCO) and safety officers' committees" and "Administrative procedure following a serious accident or incident" are available on the web at the following URLs: Code A9: http://edms.cern.ch/document/337016/LAST_RELEASED Code A10: http://edms.cern.ch/document/337019/LAST_RELEASED Code A11: http://edms.cern.ch/document/337026/LAST_RELEASED Paper copies can also be obtained from the TIS divisional secretariat, e-mail: tis.secretariat@cern.ch. TIS Secretariat

  1. Safety Culture Enhancement Project. Final Report. A Field Study on Approaches to Enhancement of Safety Culture

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, Andrew; Hayward, Brent (Dedale Asia Pacific, Albert Park VIC 3206 (Australia))

    2006-08-15

    This report documents a study with the objective of enhancing safety culture in the Swedish nuclear power industry. A primary objective of this study was to ensure that the latest thinking on human factors principles was being recognised and applied by nuclear power operators as a means of ensuring optimal safety performance. The initial phase of the project was conducted as a pilot study, involving the senior management group at one Swedish nuclear power-producing site. The pilot study enabled the project methodology to be validated after which it was repeated at other Swedish nuclear power industry sites, providing a broad-ranging analysis of opportunities across the industry to enhance safety culture. The introduction to this report contains an overview of safety culture, explains the background to the project and sets out the project rationale and objectives. The methodology used for understanding and analysing the important safety culture issues at each nuclear power site is then described. This section begins with a summary of the processes used in the information gathering and data analysis stage. The six components of the Management Workshops conducted at each site are then described. These workshops used a series of presentations, interactive events and group exercises to: (a) provide feedback to site managers on the safety culture and safety leadership issues identified at their site, and (b) stimulate further safety thinking and provide 'take-away' information and leadership strategies that could be applied to promote safety culture improvements. Section 3, project Findings, contains the main observations and output from the project. These include: - a brief overview of aspects of the local industry operating context that impinge on safety culture; - a summary of strengths or positive attributes observed within the safety culture of the Swedish nuclear industry; - a set of identified opportunities for further improvement; - the aggregated

  2. Feasibility, safety, and preliminary efficacy of Low Amplitude Seizure Therapy (LAP-ST): A proof of concept clinical trial in man.

    Science.gov (United States)

    Youssef, Nagy A; Sidhom, Emad

    2017-11-01

    Current pulse amplitude used in clinical ECT may be higher than needed. Reducing pulse amplitude may improve focality of the electric field and thus cognitive adverse effects. Here we examine the feasibility, safety, and whether Low Pulse Amplitude Seizure Therapy (LAP-ST, 0.5-0.6A) minimizes cognitive adverse effects while retaining efficacy. Patients with treatment-resistant primary mood (depressive episodes) or psychotic disorders who were clinically indicated to undergo ECT were offered to be enrolled in an open-label study. The study consisted of a full acute course of LAP-ST under standard anesthesia and muscle relaxation. The primary outcome was feasibility of seizure induction. Clinical outcome measures were: time to reorientation (TRO), Mini Mental State Examination, Montgomery Aberg Depression Scale, and Brief Psychiatric Rating Scale, and Clinical Global Impression Scale. Twenty-two patients consented for enrollment in the study. LAP-ST was feasible, and all patients had seizures in the first session. Participants had a quick orientation with median TRO of 4.5min. Treatment was efficacious for both depressive and psychotic symptoms. Relatively small sample size, non-blinded, and no randomization was performed in this initial proof of concept study. This first human preliminary data of a full course of focal LAP-ST demonstrates that seizure induction is feasible. These results, although preliminary, suggest that the LAP-ST compared to the standard ECT techniques may result in less cognitive side effects, but comparable efficacy. Larger studies are needed to replicate these findings. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Preliminary safety analysis of the B-C Cribs Controlled Area. [Hanford Reservation

    Energy Technology Data Exchange (ETDEWEB)

    Maxfield, H.L.

    1974-07-31

    Approximately 2,000 acres of land in the center of the Hanford Reservation is contaminated with an estimated 14 Ci of /sup 137/Cs and 81 Ci of /sup 90/Sr associated with animal wastes. Approximately half of this activity is located on (or within) 2.5 centimeters of the ground surface. The source of the contamination was the B-C Cribs and trenches which were used as liquid radioactive waste disposal sites during the 1950's. The mechanism for movement of radionuclides from the disposal site to the ground surface is believed to have been burrowing by an animal (probably a badger) followed by use of the exposed material as a salt lick by rabbits and other animals. When the radioactivity was discovered, the burrow was sealed, the contaminated site was classed as a radiation zone, and surveillance initiated. The contamination site has not been a significant hazard to employees at the plant or to the public. The Atlantic Richfield Hanford Company maintained control over the surface contamination by isolation, zoning, and by continued surveillance. Methods of handling the contaminated area have been considered. Discussions of these alternatives and applicable safety analysis information are included in this document.

  4. Climate change and occupational safety and health: establishing a preliminary framework.

    Science.gov (United States)

    Schulte, Paul A; Chun, HeeKyoung

    2009-09-01

    The relationship between global climate change and occupational safety and health has not been extensively characterized. To begin such an effort, it may be useful to develop a framework for identifying how climate change could affect the workplace; workers; and occupational morbidity, mortality, and injury. This article develops such a framework based on a review of the published scientific literature from 1988-2008 that includes climatic effects, their interaction with occupational hazards, and their manifestation in the working population. Seven categories of climate-related hazards are identified: (1) increased ambient temperature, (2) air pollution, (3) ultraviolet exposure, (4) extreme weather, (5) vector-borne diseases and expanded habitats, (6) industrial transitions and emerging industries; and (7) changes in the built environment. This review indicates that while climate change may result in increasing the prevalence, distribution, and severity of known occupational hazards, there is no evidence of unique or previously unknown hazards. However, such a possibility should not be excluded, since there is potential for interactions of known hazards and new conditions leading to new hazards and risks.

  5. Combustion Safety Simplified Test Protocol Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Brand, L [Gas Technology Inst., Des Plaines, IL (United States); Cautley, D. [Gas Technology Inst., Des Plaines, IL (United States); Bohac, D. [Gas Technology Inst., Des Plaines, IL (United States); Francisco, P. [Gas Technology Inst., Des Plaines, IL (United States); Shen, L. [Gas Technology Inst., Des Plaines, IL (United States); Gloss, S. [Gas Technology Inst., Des Plaines, IL (United States)

    2015-11-05

    "9Combustions safety is an important step in the process of upgrading homes for energy efficiency. There are several approaches used by field practitioners, but researchers have indicated that the test procedures in use are complex to implement and provide too many false positives. Field failures often mean that the house is not upgraded until after remediation or not at all, if not include in the program. In this report the PARR and NorthernSTAR DOE Building America Teams provide a simplified test procedure that is easier to implement and should produce fewer false positives. A survey of state weatherization agencies on combustion safety issues, details of a field data collection instrumentation package, summary of data collected over seven months, data analysis and results are included. The project provides several key results. State weatherization agencies do not generally track combustion safety failures, the data from those that do suggest that there is little actual evidence that combustion safety failures due to spillage from non-dryer exhaust are common and that only a very small number of homes are subject to the failures. The project team collected field data on 11 houses in 2015. Of these homes, two houses that demonstrated prolonged and excessive spillage were also the only two with venting systems out of compliance with the National Fuel Gas Code. The remaining homes experienced spillage that only occasionally extended beyond the first minute of operation. Combustion zone depressurization, outdoor temperature, and operation of individual fans all provide statistically significant predictors of spillage.

  6. Preliminary study on rockfall for Al Gayah site in Yemen

    Institute of Scientific and Technical Information of China (English)

    Aref M. O. Al-Jabali; WANG Xi-kui

    2004-01-01

    Studying the landslide and rockfall in Yemen still in its preliminary stage. Al Gayah rockfall site is a chronic problem as many other areas in the Republic of Yemen. The present authors have tried to highlight, and find best solution for this problem for the first time. Field work, collecting data and laboratory test for many rock samples such physical properties, chemical for major elements and thin section have been carried out. The physical properties performed according to ASTM, and then the result have been gotten and discussed.

  7. MOLECULAR IDENTIFICATION AND GENOTYPING OF CIAUSCOLO AUTOCHTHONOUS MICROFLORA: PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    A. Petruzzelli

    2011-01-01

    Full Text Available The present study reports the results of a preliminary characterization of the bacterial population of Ciauscolo, a typical Italian fermented sausage, traditionally manufactured in Marche region. The bacterial community involved in Ciauscolo fermentation was investigated using both molecular and culturebased methods. The estimation of genotypic intra-species variation of the autochthonous bacteria isolated was also evaluated by using randomly amplified polymorphic DNA (RAPD analysis and unweighted pairgroup method with arithmetic averages (UPGMA cluster analysis. Our findings revealed an high diversity of the autochthonous bacterial population investigated, both at species and strain level.

  8. Preliminary Studies on Chlorimuron Degradation in Soil by Effective Microogranisms

    Institute of Scientific and Technical Information of China (English)

    LIU Yaguang

    2006-01-01

    A wheat (Triticum aestivum L.) bioassay method was used for preliminary determination of chlorimuron degradation in soil by EM (effective microorganisms). Under the conditions of this study, chlorimuron half-life was greater than 30-50 days in soil containing different initial concentrations of chlorimuron. After adding EM, chlorimuron degradation half-life ranged from 10-15 days, which was about 15-30 days shorter than without EM. Chlorimuron phate and urea enhanced the ability of EM to degrade chlorimuron, but brown sugar had no significant effect.

  9. Study on some safety-related aspects of tyre use

    NARCIS (Netherlands)

    Jansen, S.T.H.; Schmeitz, A.J.C.; Maas, S.; Rodarius, C.; Akkermans, L.

    2014-01-01

    The tyre is a key component that affects road safety. The European commission has posted a tender aimed to study what measures on a European level can be taken in relation to the use of tyres to improve road safety. The results of this study, supported by a cost benefit analyses and carried out by

  10. Study on some safety-related aspects of tyre use

    NARCIS (Netherlands)

    Jansen, S.T.H.; Schmeitz, A.J.C.; Maas, S.; Rodarius, C.; Akkermans, L.

    2014-01-01

    The tyre is a key component that affects road safety. The European commission has posted a tender aimed to study what measures on a European level can be taken in relation to the use of tyres to improve road safety. The results of this study, supported by a cost benefit analyses and carried out by T

  11. Preliminary study of impact fragility to RC wall subjected to aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sang Shup; Hahm, Dae Gi; Choi, In Kil [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    International experience has shown that internal and external hazards such as fires, earthquakes, and aircraft impacts can be significant safety contributors to the risk to infrastructures such as nuclear power plants. Since the aircraft accident at the World Trade Center (WTC) on September 11, 2001, an aircraft impact problem has been increasingly of the interest and is one of important categories of an unexpected external hazard field. To date, aircraft impact analyses has most focused on the response analysis to the target structures. However, this preliminary study carried out an impact fragility analysis to reinforced concrete (RC) wall subjected to an aircraft impact. The aircraft velocity is used as the important variable of this study. The impact analysis of the applied Ri era's forcing function is used by Abaqus/Explicit.

  12. Safety and effectiveness of the celect inferior vena cava filter: preliminary results.

    Science.gov (United States)

    Sangwaiya, Minal Jagtiani; Marentis, Theodore C; Walker, T Gregory; Stecker, Michael; Wicky, Stephan T; Kalva, Sanjeeva P

    2009-09-01

    To evaluate the safety and effectiveness of the Celect inferior vena cava (IVC) filter during implantation, retrieval, and short-term follow-up. The clinical data of 73 patients (46 men; age range, 22-89 years) who had a Celect IVC filter implanted between August 2007 and June 2008 were reviewed. Twenty-one (28.8%) presented with pulmonary embolism (PE), 15 (20.54%) with deep vein thrombosis (DVT), 12 (16.4%) with both, and the rest (34.26%) with other symptoms. Indications for filter placement were contraindication to anticoagulation (n = 38; 52%), prophylaxis/added protection (n = 22; 30%), failure of anticoagulation (n = 11; 15%), and complications of anticoagulation (n = 2; 3%). Filters were placed in the infrarenal (n = 71) or suprarenal (n = 2) IVC. Follow-up data were reviewed for filter-related complications and recurrent PE. All filters were successfully deployed. Immediately after fluoroscopy-guided filter deployment in 61 patients, four filters (6.5%) showed significant tilt. During follow-up (mean, 68 days +/- 73), three patients developed symptoms of PE after filter placement; however, computed tomographic (CT) pulmonary angiography demonstrated new PE in only two. Imaging follow-up with radiography (n = 32), CT (n = 11), and/or angiography (n = 4) in 47 patients (at a mean of 62 days +/- 75) showed no filter migration. Follow-up abdominal CT (at a mean of 69 days +/- 58) was available in 18 patients and demonstrated filter-related problems in seven (39%). These included penetration of filter legs in four and fracture/migration of filter components in one. Fourteen filters were successfully retrieved after a median period of 84 days. The Celect IVC filter can be safely placed but is related to a high incidence of caval filter leg penetration. Symptomatic PE after filter placement confirmed by CT occurred in 2.8% of patients.

  13. Joint SKI and SSI review of SKB preliminary safety assessment of repository for long-lived low- and intermediate-level waste. Review report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    SKI and SSI find that SKB's first proper safety assessment of the SFL 3-5 repositories provides a valuable springboard for continued efforts in this field. Even though the safety assessment is relatively limited in scope, it has numerous merits. The specific problems associated with the chosen repository concept for SFL 3-5 are discussed in a generally transparent manner. On the other hand, the authorities consider that SKB have only partly achieved the expressed goal of studying the significance of the current repository design and the choice of site. The greatest deficiency consists in that neither internal disturbances (such as considerable cracking or degradation of concrete structures) nor external disturbances (such as the effects of climate changes and glaciation) have been addressed in a thorough manner. A coherent report justifying the design choice from a long-term safety perspective is, in large part, not found here. SKI and SSI recommend that SKB provide a comparison with other possible SFL 3-5 repository designs. Depending upon, among other factors, what geospheric and biospheric conditions are assumed, SKB have shown that the calculated dose values could be relatively high for certain cases. More realistic assessments would be needed to draw reasonable comparisons between different sites, and to evaluate the importance of different nuclides in different contexts. Our review of SKBs preliminary safety assessment indicates that a great deal of research and development work remains to be done before the level of knowledge in this field is comparable with that associated with the final repository for spent fuel. This is reflected with unanimity in the international expert committee's review, and in the consultants' reviews. SKI and SSI wish to point out in particular the fact that comparison with SFR is of limited value, since the safety associated with SFL 3- 5 must be assessed on a much longer time scale. SKI and SSI find it remarkable

  14. Corporate Social Disclosures in Southeast Asia: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Juniati Gunawan

    2012-12-01

    Full Text Available The issue of Corporate Social Disclosure (CSD has been growing remarkably both in business and academic world.  Inevitably, this topic is also exposed in Southeast Asia, a big region that plays important role in global economic issue. Applying a content analysis method, this paper aims to provide preliminary findings in CSD practices throughout the companies‟ annual reports in 2007 and 2008 for countries located in Southeast Asia.  Samples were selected for listed and unlisted various type of industries, based on the information availability internet searching. The sample collection and the subjectivity during the content analysis process are the limitations in conducting this study. In general, the results show that „human resources‟ are the main information disclosed, while in contrast, „energy‟ is the main least issue disclosed in the annual reports.  However, the findings need to be interpreted with considerations since there are limited in samples. Basically, the outcomes support the major prior studies and enhancing the discussion of CSD conducting in developing countries, while at the same time describing some countries which obtained very limited in exposures. To respond the vast increasing issues of CSD practice, this preliminary study has provided a basis to see the role of every country in CSR reporting and how they could support the sustainability development globally.

  15. Combustion Safety Simplified Test Protocol Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Brand, L. [Gas Technology Inst., Des Plaines, IL (United States); Cautley, D. [Gas Technology Inst., Des Plaines, IL (United States); Bohac, D. [Gas Technology Inst., Des Plaines, IL (United States); Francisco, P. [Gas Technology Inst., Des Plaines, IL (United States); Shen, L. [Gas Technology Inst., Des Plaines, IL (United States); Gloss, S. [Gas Technology Inst., Des Plaines, IL (United States)

    2015-11-01

    Combustions safety is an important step in the process of upgrading homes for energy efficiency. There are several approaches used by field practitioners, but researchers have indicated that the test procedures in use are complex to implement and provide too many false positives. Field failures often mean that the house is not upgraded until after remediation or not at all, if not include in the program. In this report the PARR and NorthernSTAR DOE Building America Teams provide a simplified test procedure that is easier to implement and should produce fewer false positives. A survey of state weatherization agencies on combustion safety issues, details of a field data collection instrumentation package, summary of data collected over seven months, data analysis and results are included. The project team collected field data on 11 houses in 2015.

  16. Preliminary Study of Single-Phase Natural Circulation for Lab-scaled Molten Salt Application

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Yukyung; Kang, Sarah; Kim, In Guk; Seo, Seok Bin; Bang, In Cheol [UNIST, Ulsan (Korea, Republic of); Park, Seong Dae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Advanced reactors such as MSR (FHR), VHTR and AHTR utilized molten salt as a coolant for efficiency and safety which has advantages in higher heat capacity, lower pumping power and scale compared to liquid metal. It becomes more necessary to study on the characteristics of molten salt. However, due to several characteristics such as high operating temperature, large-scale facility and preventing solidification, satisfying that condition for study has difficulties. Thus simulant fluid was used with scaling method for lab-scale experiment. Scaled experiment enables simulant fluid to simulate fluid mechanics and heat transfer behavior of molten salt on lower operating temperature and reduced scale. In this paper, as a proof test of the scaled experiment, simplified single-phase natural circulation loop was designed in a lab-scale and applied to the passive safety system in advanced reactor in which molten salt is considered as a major coolant of the system. For the application of the improved safety system, prototype was based on the primary loop of the test-scale DRACS, the main passive safety system in FHR, developed at the OSU. For preliminary experiment, single-phase natural circulation under low power was performed. DOWTHERM A and DOWTHERM RP were selected as simulant candidates. Then, study of feasibility with simulant was conducted based on the scaling law for heat transfer characteristics and geometric parameters. Additionally, simulation with MARS code and ANSYS-CFX with the same condition of natural circulation was carried out as verification. For the accurate code simulation, thermo-physical properties of DOWTHERM A and RP were developed and implemented into MARS code. In this study, single-phase natural circulation experiment was performed with simulant oil, DOWTHERM RP, based on the passive safety system of FHR. Feasibility of similarity experiment for molten salt with oil simulant was confirmed by scaling method. In addition, simulation with two

  17. Nevada potential repository preliminary transportation strategy Study 2. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    The objectives of this study were to build on the findings of the Nevada Potential Repository Preliminary Transportation Strategy Study 1 (CRWMS M&O 1995b), and to provide additional information for input to the repository environmental impact statement (EIS) process. In addition, this study supported the future selection of a preferred rail corridor and/or heavy haul route based on defensible data, methods, and analyses. Study research did not consider proposed legislation. Planning was conducted according to the Civilian Radioactive Waste Management Program Plan (DOE 1994a). The specific objectives of Study 2 were to: eliminate or reduce data gaps, inconsistencies, and uncertainties, and strengthen the analysis performed in Study 1; develop a preliminary list of rail route evaluation criteria that could be used to solicit input from stakeholders during scoping meetings. The evaluation criteria will be revised based on comments received during scoping; restrict and refine the width of the four rail corridors identified in Study 1 to five miles or less, based on land use constraints and engineering criteria identified and established in Study 2; evaluate national-level effects of routing spent nuclear fuel and high-level waste to the four identified branch lines, including the effects of routing through or avoiding Las Vegas; continue to gather published land use information and environmental data to support the repository EIS; continue to evaluate heavy haul truck transport over three existing routes as an alternative to rail and provide sufficient information to support the repository EIS process; and evaluate secondary uses for rail (passenger use, repository construction, shared use).

  18. R&D Requirements, RF Gun Mode Studies, FEL-2 Steady-StateStudies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary LayoutOption Investigation

    Energy Technology Data Exchange (ETDEWEB)

    Byrd, John; Corlett, John; Doolittle, Larry; Fawley, William; Lidia, Steven; Penn, Gregory; Ratti, Alex; Staples, John; Wilcox Russell; Wurtele, Jonathan; Zholents, Alexander

    2005-10-01

    This report constitutes the third deliverable of LBNLs contracted role in the FERMI {at} Elettra Technical Optimization study. It describes proposed R&D activities for the baseline design of the Technical Optimization Study, initial studies of the RF gun mode-coupling and potential effects on beam dynamics, steady-state studies of FEL-2 performance to 10 nm, preliminary studies of time-dependent FEL-1 performance using electron bunch distribution from the start-to-end studies, and a preliminary investigation of a configuration with FEL sinclined at a small angle from the line of the linac.

  19. Age and Workers' Perceptions of Workplace Safety: A Comparative Study

    Science.gov (United States)

    Gyekye, Seth Ayim; Salminen, Simo

    2009-01-01

    The study examined the relationship between age and I) safety perception; ii) job satisfaction; iii) compliance with safety management policies; and (iv) accident frequency. Participants were Ghanaian industrial workers (N = 320) categorized into 4 age groups: 19-29 years; 30-39 years; 40-50 years; and 51 years and above. Workplace safety…

  20. Subcutaneous administration of paclitaxel in dogs with cancer: A preliminary study.

    Science.gov (United States)

    Silva, Daniella M; Franciosi, Aline I; Pezzini, Paula C F; Guérios, Simone D

    2015-08-01

    Intravenous paclitaxel has been underused in dogs due to severe and acute hypersensitivity reactions. Subcutaneous (SC) administration of paclitaxel and its safety are unknown. In this preliminary study, SC administration of paclitaxel was evaluated for hypersensitivity reactions and toxicity in 21 dogs with advanced cancer. Dogs received 1 to 5 paclitaxel doses, ranging from 85 to 170 mg/m(2), SC every 14 or 21 days. A total of 40 paclitaxel doses were administered and none of the 21 dogs developed systemic or acute local hypersensitivity reactions. Severe skin lesions at the injection site developed in 2 dogs after the 4th injection at the same location. Grade 4 neutropenia was observed in 50% of the dogs 5 days after the first treatment at 115 mg/m(2) (n = 14). Two animals developed Grade 5 diarrhea and died likely due to hemodynamic failure or sepsis. Paclitaxel can be administered SC in dogs with no hypersensitivity reaction.

  1. Prescription-event monitoring. A preliminary study of benoxaprofen and fenbufen.

    Science.gov (United States)

    Inman, W H

    1984-01-01

    Prescription-Event Monitoring (PEM) has been established at the Drug Surveillance Research Unit of the University of Southampton as a low-cost technique for ascertaining the pattern of events, whether drug-related or not, in large general practice cohorts. The reporting of "events" without the need for an opinion about the probability that they may be adverse drug reactions (ADRs) removes much of the uncertainty inherent in voluntary ADR reporting systems. Numerators (adverse events) and denominators (the number of prescriptions), enable estimates of incidence to be derived from the data. Where related drugs are studied concurrently, differences in the pattern of events may signal important differences in their safety or efficacy . A successful large-scale preliminary exercise involving nearly 9 000 doctors and 16 000 patients is described.

  2. A Preliminary Case Study for Rectenna Sites in Indonesia

    Science.gov (United States)

    Purwanto, Y.; Collins, P.

    2004-12-01

    Electricity power generation using alternative energy sources in Indonesia has become an important policy. Until now, the contribution from alternative energy sources (especially from renewable energy sources) is very small, only about 1% of the total energy supply. It is expected that in the next 10 years this contribution will be raised to 20%. The development of renewable energy sources is primarily performed in remote areas, that are poor in infrastructure facilities. This is considered to be a good policy since there are many such remote areas in Indonesia that need development programs. The existence of Solar Power Satellite system will open a new horizon in alternative energy supply, including Indonesia, because of its higher efficiency compared to conventional terrestrial solar cells, with almost no influence from either climate or solar position. Like other countries in the world, Indonesia, although one of the largest mineral energy producers in the world (i.e. oil, coal, and natural gas), still gives attention to energy diversification programs, including solar energy utilization. SPS, being based on solar energy, could be a good choice. The Indonesian archipelago consists of thousands of islands (more than 13,000) and is the equatorial country with the longest equatorial extent (more than 5000 km). This condition is very good for energy reception from the SPS 2000 pilot plant since the energy transmitting system (spacetenna) will orbit above the equator. Along the equator there could be placed more than four receiving stations (rectenna), especially in remote areas. Thus, it is very important to consider the involvement of Indonesia in SPS energy reception research. This paper describes a preliminary study of the development possibilities in SPS energy reception in Indonesia. To define the rectenna sites and physical development aspect, this study considers some major aspects: environmental, technical, social, and economic aspects. Environmental aspects

  3. Safety Culture Enhancement Project. Final Report. A Field Study on Approaches to Enhancement of Safety Culture

    Energy Technology Data Exchange (ETDEWEB)

    Lowe, Andrew; Hayward, Brent (Dedale Asia Pacific, Albert Park VIC 3206 (Australia))

    2006-08-15

    This report documents a study with the objective of enhancing safety culture in the Swedish nuclear power industry. A primary objective of this study was to ensure that the latest thinking on human factors principles was being recognised and applied by nuclear power operators as a means of ensuring optimal safety performance. The initial phase of the project was conducted as a pilot study, involving the senior management group at one Swedish nuclear power-producing site. The pilot study enabled the project methodology to be validated after which it was repeated at other Swedish nuclear power industry sites, providing a broad-ranging analysis of opportunities across the industry to enhance safety culture. The introduction to this report contains an overview of safety culture, explains the background to the project and sets out the project rationale and objectives. The methodology used for understanding and analysing the important safety culture issues at each nuclear power site is then described. This section begins with a summary of the processes used in the information gathering and data analysis stage. The six components of the Management Workshops conducted at each site are then described. These workshops used a series of presentations, interactive events and group exercises to: (a) provide feedback to site managers on the safety culture and safety leadership issues identified at their site, and (b) stimulate further safety thinking and provide 'take-away' information and leadership strategies that could be applied to promote safety culture improvements. Section 3, project Findings, contains the main observations and output from the project. These include: - a brief overview of aspects of the local industry operating context that impinge on safety culture; - a summary of strengths or positive attributes observed within the safety culture of the Swedish nuclear industry; - a set of identified opportunities for further improvement; - the aggregated

  4. Results of preliminary Microwave Multi-Applications Payload (MMAP) study

    Science.gov (United States)

    1975-01-01

    A preliminary feasibility study of the microwave multi-applications payload (MMAP) system for the Spacelab has been carried out. The initial objectives of this study have been to determine the minimum equipment requirements of the MMAP and the feasibility of placing the numerous large aperture antennas in the Spacelab. The study was begun by reviewing the experimental objectives and techniques and determining areas of commonality. Emphasis was given to the determination of common RF equipment requirements. These requirementers were considered after agreement among the experiments had been reached on limiting the number of frequencies to be used in the system. This was done so that the number of antennas, transmitters, and receivers could be minimized. The electronics system block diagram and the antenna configurations were considered in some details. It was concluded that the MMAP is feasible and can be an economical method of achieving a large number of experimental goals.

  5. A PRELIMINARY STUDY OF STEREOSELECTIVITY OF MEFLOQUINE ENANTIOMERS IN RAT

    Directory of Open Access Journals (Sweden)

    E. Souri.

    1998-08-01

    Full Text Available Stereoselectivity of mefloquine enantiomers were studied in rats after oral administration of a single 50mg/Kg dose of the racemate. Pharmacokinetic parameters of (+-(RS-MFQ in blood and plasma showed no significant difference. The concentration, AUC , CLIF and VdlF of (+-(RS-enantiomerin blood were significantly higher than those for the (--(SR-enantiomer. Tlie results obtained from this study showed a reverse stereoselectivity of MFQ as compared with what reported for human. A very low amount of enantiomers excreted in urine and the excretion was not stereoselective. A preliminary study in different blood fractions showed that the accumulation of MFQ enantiomers in blood cells is stereoselective with a tendency of ( + -(RS-enatiomer for leukocytes and (--(SR-enantiomer for erythrocytes.

  6. Pharmacoepidemiological safety studies in children: a systematic review

    NARCIS (Netherlands)

    O.U. Osokogu (Osemeke); Dukanovic, J. (Julijana); C. Ferrajolo (Carmen); C. Dodd (Caitlin); A.C. Pacurariu (Alexandra C.); W.M. Bramer (Wichor); 'tJong, G. (Geert); D.M. Weibel (Daniel); M.C.J.M. Sturkenboom (Miriam); F. Kaguelidou (Florentia)

    2016-01-01

    textabstractPurpose: In order to identify challenges in pediatric pharmacoepidemiological safety studies, we assessed the characteristics of such (published) studies. Methods: Relevant articles from inception to 2013 were retrieved from Embase and Medline. We sequentially screened titles, abstracts

  7. On the safety of aircraft systems: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Guridi, G.; Hall, R.E.; Fullwood, R.R.

    1997-05-14

    An airplane is a highly engineered system incorporating control- and feedback-loops which often, and realistically, are non-linear because the equations describing such feedback contain products of state variables, trigonometric or square-root functions, or other types of non-linear terms. The feedback provided by the pilot (crew) of the airplane also is typically non-linear because it has the same mathematical characteristics. An airplane is designed with systems to prevent and mitigate undesired events. If an undesired triggering event occurs, an accident may process in different ways depending on the effectiveness of such systems. In addition, the progression of some accidents requires that the operating crew take corrective action(s), which may modify the configuration of some systems. The safety assessment of an aircraft system typically is carried out using ARP (Aerospace Recommended Practice) 4761 (SAE, 1995) methods, such as Fault Tree Analysis (FTA) and Failure Mode and Effects Analysis (FMEA). Such methods may be called static because they model an aircraft system on its nominal configuration during a mission time, but they do not incorporate the action(s) taken by the operating crew, nor the dynamic behavior (non-linearities) of the system (airplane) as a function of time. Probabilistic Safety Assessment (PSA), also known as Probabilistic Risk Assessment (PRA), has been applied to highly engineered systems, such as aircraft and nuclear power plants. PSA encompasses a wide variety of methods, including event tree analysis (ETA), FTA, and common-cause analysis, among others. PSA should not be confused with ARP 4761`s proposed PSSA (Preliminary System Safety Assessment); as its name implies, PSSA is a preliminary assessment at the system level consisting of FTA and FMEA.

  8. Preliminary Studies for Three Experiments at Treiman-Yang Criterion

    Science.gov (United States)

    Kres, I. V.; Kondratyev, V. N.; Cherubini, S.; Spitaleri, C.

    2016-05-01

    Nuclear reactions with three bodies in their final state may proceed through different reaction mechanisms. The Feynman graph technique has been widely used to describe such reactions. However, it is very difficult in general to select the graphs that dominate in given process. The Treiman-Yang criterion is one of the most powerful experimental tests for verifying the pole approximation prediction when describing a quasi-free reaction mechanism. We propose the theoretical study of the H2(B10, α Be7)ns, H1(B11, α1α2)αs, He3(Be9, α1α2)αs reactions at different energies. The preliminary study helps to check the existence of a QF channel by using the TY creterion.

  9. Recurrent laryngeal nerve histopathology in spastic dysphonia: a preliminary study.

    Science.gov (United States)

    Dedo, H H; Izdebski, K; Townsend, J J

    1977-01-01

    Spastic dysphonia is a severe voice disorder ordinarily described as psychogenic. Organic-neurologic changes secondary to central or peripheral nervous system involvement have also been postulated and led recently to the surgical treatment of spastic dysphonia by unilateral section of the recurrent laryngeal nerve (RLN). This study reports the histologic findings from these resections of the RLN from patients with an average 9.5 years duration of spastic dysphonia. Thirty percent of the RLNs examined demonstrated significant abnormalities as compared to age-matched controls. Although no reactive changes were noted by light microscopy, groups of fibers which did not stain for myelin or axons were found in RLNs from patients with spastic dysphonia. A preliminary ultrastructural study of these areas in one RLN revealed sheets of unmyelinated axons. These findings suggest an organic basis for spastic dysphonia at least in some patients.

  10. First Breath prenatal smoking cessation pilot study: preliminary findings.

    Science.gov (United States)

    Jehn, Lisette; Lokker, Nicole; Matitz, Debra; Christiansen, Bruce

    2003-01-01

    Despite the many dangers associated with smoking during pregnancy, it remains a salient public health problem for Wisconsin women. The First Breath pilot program was developed in an attempt to reduce rates of smoking during pregnancy among low-income women. Preliminary results suggest that the First Breath counseling-based approach is effective, with a quit rate of 43.8% among First Breath enrollees at 1 month postpartum. Women receiving First Breath cessation counseling also had higher quit rates at every measurement period versus women in a comparison group who were receiving whatever cessation care was available in their county in the absence of First Breath. The First Breath pilot study has demonstrated success in helping pregnant women quit smoking and in creating a model for integration of cessation services into prenatal health care service provision. It is through this success that First Breath is expanding beyond the pilot study stage to a statewide program in 2003.

  11. Applicability of bosentan in Dutch patients with Eisenmenger syndrome : preliminary results on safety and exercise capacity

    NARCIS (Netherlands)

    Duffels, M.G.J.; Berger, R.M.F.; Bresser, P.; de Bruin-Bon, H.A.C.M.; Hoendermis, E.; Bouma, Berto J.; Mulder, B.J.M.

    2006-01-01

    BACKGROUND: The purpose of this study was to investigate the applicability of bosentan treatment in a broad selection of patients with Eisenmenger syndrome. METHODS: Dutch patients with Eisenmenger syndrome in New York Heart Association functional class III, 9 (41%) male and 13 (59%) female, includi

  12. On safety management and nuclear safety - A frame of reference for studies of safety management with examples from non-nuclear contects of relevance for nuclear safety

    Energy Technology Data Exchange (ETDEWEB)

    Svenson, O.; Allwin, P. [Stockholm Univ. (Sweden); Salo, I. [Lund Univ. (Sweden)

    2004-03-01

    The report includes three case studies of safety management. The studies are presented as chapters, but are written in a format that makes them easy to read separately. Two of the studies cover regulators (the Swedish Civil Aviation Safety Authority, Luftfartsinspektionen) and the Norwegian Petroleum Directorate) and one a regulated activity/industry (a car manufacturer, Volvo Car). The introduction outlines a living system framework and relates this to concepts used in organizational management. The report concludes with some findings with potential relevance for safety management in the nuclear power domain. In the next phase of the work, the regulated counterparts of the regulators here will be investigated in addition to a fourth case study of a regulated activity/industry. (au)

  13. Preliminary safety analysis of Pb-Bi cooled 800 MWt modified CANDLE burn-up scheme based fast reactors

    Science.gov (United States)

    Su'ud, Zaki; Sekimoto, H.

    2014-09-01

    Pb-Bi Cooled fast reactors with modified CANDLE burn-up scheme with 10 regions and 10 years cycle length has been investigated from neutronic aspects. In this study the safety aspect of such reactors have been investigated and discussed. Several condition of unprotected loss of flow (ULOF) and unprotected rod run-out transient over power (UTOP) have been simulated and the results show that the reactors excellent safety performance. At 80 seconds after unprotected loss of flow condition, the core flow rate drop to about 25% of its initial flow and slowly move toward its natural circulation level. The maximum fuel temperature can be managed below 1000°C and the maximum cladding temperature can be managed below 700°C. The dominant reactivity feedback is radial core expansion and Doppler effect, followed by coolant density effect and fuel axial expansion effect.

  14. SAFETY OF EARLY ORAL FEEDING AFTER TRANSHIATAL ESOPHAGECTOMY : PRELIMINARY REPORT OF A PROSPECTIVE TRIAL

    Directory of Open Access Journals (Sweden)

    A. Jafarian

    2005-09-01

    Full Text Available Oral feeding is the best means of nutrition in surgical patients. There arc many reports on early oral feeding after lower gastrointestinal {(il operations but data regarding upper Gl procedures is rather scant. This limited study rocuses 011 early removal of nasogastric tube and start of oral diet after transhiatal csophagcctomy. We prospectively evaluated 13 consecutive patients (8 males. 5 females with esophageal cancer who had undergone rranshiatal csophngcctomy from March 100 I to September :lOrn. Nasogustric tube was removed on post-op day 1 and clear liquids started on day 3. Diet was advanced to son regular in tile next 5 days if the patients tolerated it. Mean age of patients was 63 years."nMenu body weight and serum albumin level were 57.9 kg and 3.73 gr/dl., respectively. Tumor pathology was squamous cell carcinoma in 11 cases and adenocarcinoma in I. Location oftumor was at the lower third of the esophagus in 11 cases and middle third in one. All patients ill the study group tolerated tile protocol well. Only one patient had nausea after oral intake, without vomiting. We had one neck wound infection and OIlC pulmonary infection. There was no anastomotic leakage or fistula. A group of I( esophageal cancer patients undergoing trnnshiuta! csophagcctomy in the same period ""'('I'C used as the control group. One anastomotic leakage occurred in control group. We had no significant complication. Early nasogastric tube removal and oral feeding seems to be safe in patients with esophageal cancer undergoing transhiatal csophagcctcmy.

  15. Primate phylogeny studied by comparative determinant analysis. A preliminary report.

    Science.gov (United States)

    Bauer, K

    1993-01-01

    In this preliminary report the divergence times for the major primate groups are given, calculated from a study by comparative determinant analysis of 69 proteins (equaling 0.1% of the whole genetic information). With an origin of the primate order set at 80 million years before present, the ages of the last common ancestors (LCAs) of man and the major primate groups obtained this way are as follows: Pan troglodytes 5.2; Gorilla gorilla 7.4; Pongo pygmaeus 19.2; Hylobates lar 20.3; Old World monkeys 31.4; Lagothrix lagotricha 46.0; Cebus albifrons 59.5; three lemur species 67.0, and Galago crassicaudatus 73.3 million years. The LCA results and the approach are shortly discussed. A full account of this extended investigation including results on nonprimate mammals and on the determinant structures and the immunologically derived evolutionary rates of the proteins analyzed will be published elsewhere.

  16. PRELIMINARY STUDY OF EXTRACTABLE PROTEIN BINDING USING MALEIC ANHYDRIDE COPOLYMER

    Institute of Scientific and Technical Information of China (English)

    Thirawan Nipithakul; Ladawan Watthanachote; Nanticha Kalapat

    2012-01-01

    A preliminary study of using maleic anhydride copolymer for protein binding has been carried out.The polymeric films were prepared by compression of the purified resin and annealing the film to induce efficient back formation of the anhydride groups.The properties of the film surface were analyzed by attenuated total reflection Fourier transforms infrared spectroscopy and water contact angle measurements.The protein content was determined by Bradford assay.To obtain optimum conditions,immersion time for protein binding was examined.Results revealed that proteins can be successfully immobilized onto the film surface via covalent linkage.The efficiency of the covalent binding of the extractable protein to maleic anhydride-polyethylene film was estimated at 69.87 μtg/cm2,although the film had low anhydride content (3%) on the surface.

  17. Proscriptive Bayesian Programming and Maximum Entropy: a Preliminary Study

    Science.gov (United States)

    Koike, Carla Cavalcante

    2008-11-01

    Some problems found in robotics systems, as avoiding obstacles, can be better described using proscriptive commands, where only prohibited actions are indicated in contrast to prescriptive situations, which demands that a specific command be specified. An interesting question arises regarding the possibility to learn automatically if proscriptive commands are suitable and which parametric function could be better applied. Lately, a great variety of problems in robotics domain are object of researches using probabilistic methods, including the use of Maximum Entropy in automatic learning for robot control systems. This works presents a preliminary study on automatic learning of proscriptive robot control using maximum entropy and using Bayesian Programming. It is verified whether Maximum entropy and related methods can favour proscriptive commands in an obstacle avoidance task executed by a mobile robot.

  18. STUDYING OF SAFETY CLIMATE ASSESSMENT: A CASE STUDY AT STEEL INDUSTRY

    Directory of Open Access Journals (Sweden)

    Hassan DARVISH

    2011-01-01

    Full Text Available Evolution of safety climate used as a practical means has determined and assessed potential problems relevant to safety issues in an organization and can be used in individuals’ performance and work efficiency and decreasing rate of incidents ;as well as; guidance to provide safety organization policy and comparison of safety performance in different organizations. The study wants to determine and prepare safety climate profile and application of its results in improving safety situation. In this study, applied tools presented by Loughborough University are used to evaluate safety climate in one of steel industries and data is collected through questionnaire, group discussions or purposeful interviews and observations, and safety climate score was obtained in 17 scopes. Calculating the score of each safety climate domain and preparing the profile indicated there is the average rate (4.89 2 in the safety climate of the industry.

  19. Study of evaluation methods for in-vessel corium retention through external vessel cooling and safety of reactor cavity

    Energy Technology Data Exchange (ETDEWEB)

    Huh, Hoon; Chang, Soon Heung; Choi, Tae Hoon; Kim, Hyun Sop; Yang, Soo Hyung; Kim, Soo Hyung; Kim, Seung Hop; An Hyung Taek; Jeong, Yong Hoon; Huh, Gyun Young [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1998-03-15

    Cooling methodologies for the molten corium resulted from the severe accident of the nuclear power plant is suggested as one of most important items for the safety of the NPP. In this regard, considerable experimental and analytical works have been devoted. In the 1st phase of this project, present status related to the external reactor vessel cooling for the retention of the corium in the reactor vessel and corium at the reactor cavity have been investigated and preliminary studies have been accomplished for the detail evaluation of the each cooling methodology. The preliminary studies include the analysis and detail investigation of the possible phenomena, investigation of the heat transfer correlations and preliminary evaluation of the external reactor vessel cooling using the developed computer code.

  20. MICE -- Absorber and focus coil safety working group design document: Preliminary design and assessments

    Energy Technology Data Exchange (ETDEWEB)

    Barr, Giles; Baynham, Elwyn; Black, Edgar; Bradshaw, Tom; Cummings, Mary Anne; Green, Michael A.; Ishimoto, Shigeru; Ivanyushenkov, Yury; Lau, Wing; Zisman, Michael

    2003-12-04

    A Neutrino Factory based on a muon storage ring is the ultimate tool for studies of neutrino oscillations, including possibly the discovery of leptonic CP violation. it is also the first step toward a muon collider. To develop a stored-muon-beam facility to serve as a Neutrino Factory, it is necessary to ''cool'' a muon beam (decrease its phase-space volume). The short lifetime of the muon, 2.2 {micro}s at rest, eliminates all currently demonstrated cooling techniques and requires that a new, heretofore untried, technique--ionization cooling--be employed. Although ionization cooling of muons has never been demonstrated in practice, it has been shown by end-to-end simulation and design studies to be an important factor both for the performance and for the cost of a Neutrino Factory. This motivates an international program of R and D, including an experimental demonstration at Rutherford Appleton Laboratory (RAL). The aims of the international Muon Ionization Cooling Experiment are: (1) to show that it is possible to design, engineer and build a section of cooling channel capable of giving the desired performance for a Neutrino Factory; and (2) to place it in a muon beam and measure its performance in various modes of operation and beam conditions, thereby investigating the limits and practicality of cooling. The MICE collaboration has designed an experiment in which a section of an ionization cooling channel is exposed to a muon beam. This cooling channel assembles liquid-hydrogen absorbers providing energy loss and high-gradient radio frequency (RF) cavities to re-accelerate the particles, all tightly contained in a magnetic channel. It reduces the beam transverse emittance by > 10% for muon momenta between 140 and 240 MeV/c. The layout of the experiment is shown. They utilize one complete magnetic cell of the cooling channel, comprising three absorber-focus-coil (AFC) modules and two RF-coupling-coil (RFCC) modules. Spectrometers placed before

  1. Mathematical modeling of normal pharyngeal bolus transport: a preliminary study.

    Science.gov (United States)

    Chang, M W; Rosendall, B; Finlayson, B A

    1998-07-01

    Dysphagia (difficulty in swallowing) is a common clinical symptom associated with many diseases, such as stroke, multiple sclerosis, neuromuscular diseases, and cancer. Its complications include choking, aspiration, malnutrition, cachexia, and dehydration. The goal in dysphagia management is to provide adequate nutrition and hydration while minimizing the risk of choking and aspiration. It is important to advance the individual toward oral feeding in a timely manner to enhance the recovery of swallowing function and preserve the quality of life. Current clinical assessments of dysphagia are limited in providing adequate guidelines for oral feeding. Mathematical modeling of the fluid dynamics of pharyngeal bolus transport provides a unique opportunity for studying the physiology and pathophysiology of swallowing. Finite element analysis (FEA) is a special case of computational fluid dynamics (CFD). In CFD, the flow of a fluid in a space is modeled by covering the space with a grid and predicting how the fluid moves from grid point to grid point. FEA is capable of solving problems with complex geometries and free surfaces. A preliminary pharyngeal model has been constructed using FEA. This model incorporates literature-reported, normal, anatomical data with time-dependent pharyngeal/upper esophageal sphincter (UES) wall motion obtained from videofluorography (VFG). This time-dependent wall motion can be implemented as a moving boundary condition in the model. Clinical kinematic data can be digitized from VFG studies to construct and test the mathematical model. The preliminary model demonstrates the feasibility of modeling pharyngeal bolus transport, which, to our knowledge, has not been attempted before. This model also addresses the need and the potential for CFD in understanding the physiology and pathophysiology of the pharyngeal phase of swallowing. Improvements of the model are underway. Combining the model with individualized clinical data should potentially

  2. Canadian Consumer Food Safety Practices and Knowledge: Foodbook Study.

    Science.gov (United States)

    Murray, Regan; Glass-Kaastra, Shiona; Gardhouse, Christine; Marshall, Barbara; Ciampa, Nadia; Franklin, Kristyn; Hurst, Matt; Thomas, M Kate; Nesbitt, Andrea

    2017-10-01

    Understanding consumers' food safety practices and knowledge supports food safety education for the prevention of foodborne illness. The objective of this study was to describe Canadian consumer food safety practices and knowledge. This study identifies demographic groups for targeted food safety education messaging and establishes a baseline measurement to assess the effectiveness of food safety interventions over time. Questions regarding consumer food safety practices and knowledge were included in a population-based telephone survey, Foodbook, conducted from November 2014 to March 2015. The results were analyzed nationally by age group and by gender. The results showed that approximately 90% of Canadians reported taking the recommended cleaning and separating precautions when handling raw meat to prevent foodborne illness. Only 29% of respondents reported using a food thermometer when cooking any meat, and even fewer (12%) reported using a food thermometer for small cuts of meat such as chicken pieces. The majority (>80%) of Canadians were aware of the foodborne illness risks related to chicken and hamburger, but fewer (food safety education in Canada should focus on increasing people's awareness of high-risk foods, specifically foods for which the awareness of risk found in this study was low; targeting messaging to demographic groups as appropriate; and promoting the use of food thermometers when cooking meat and poultry.

  3. Preliminaries toward studying resonant extraction from the Debuncher

    Energy Technology Data Exchange (ETDEWEB)

    Michelotti, Leo; Johnstone, John; /Fermilab

    2009-06-01

    A recent proposal to detect {mu} {yields} e direct conversion at Fermilab asks for slow extraction of protons from the antiproton source, specifically from the Debuncher. [1] A third-integer resonance originally was considered for this, partly because of the Debuncher's three-fold symmetry and partly because its operational horizontal tune, {nu}{sub x} {approx} 9.765, is already within 0.1 of {nu}{sub x} = 29/3. Using a half integer resonance, {nu}{sub x} = 19/2, though not part of the original proposal, has been suggested more recently because (a) Fermilab has had a good deal of experience with half-integer extraction from the Tevatron, the Main Injector and the erstwhile Main Ring, and (b) for reasons we shall examine later, it depopulates the entire bunch without an abort at the end. This memo presents considerations preliminary to studying both possibilities. It is meant only as a starting point for investigations to be carried out in the future. The working constraints and assumptions have oscillated between two extremes: (1) making minimal changes in the antiproton source to minimize cost and (2) building another machine in the same tunnel. In this memo we adopt an attitude aligned more toward the first. The assumed parameters are listed in Table 1. A few are not (easily) subject to change, such as those related to the beam's momentum and revolution frequency and the acceptance of the debuncher. Two resonance exemplars are presented in the next section, with an explanation of the analytic and semi-analytic calculations that can be done for each. Section 3 contains preliminary numerical work that was done to validate the exemplars within the context of extraction from the Debuncher. A final section contains a summary. Following the bibliography, appendices contain (a) a qualitative, conceptual discussion of extraction for the novice, (b) a telegraphic review of the perturbative incantations used to filter the exemplars as principal resonances of

  4. Study Sheds Light on Safety of Driving with Epilepsy

    Science.gov (United States)

    ... Study Sheds Light on Safety of Driving With Epilepsy Those who had longer seizures during driving tests ... SUNDAY, Dec. 4, 2016 (HealthDay News) -- People with epilepsy who experienced longer seizures during a simulated driving ...

  5. Analysis Study of Survey for Safety and Efficacy of Pharmacopuncture

    OpenAIRE

    Hong Kwon-eui

    2010-01-01

    This study was done in order to present clinical trial method for safety and efficacy of Pharmacopuncture. The results were summarized as follow:Objective : The purpose of this study is to verify about safety and effectiveness of pharmacopuncture. Methods : We use questionnaire created by expert group. Survey was conducted to target clinicians who using pharmacopuncture more then 5 years. Results & Conclusion : Pharmacopuncture is effective. and that is widely used in the musculoskeleta...

  6. Behavior-based safety on construction sites: a case study.

    Science.gov (United States)

    Choudhry, Rafiq M

    2014-09-01

    This work presents the results of a case study and describes an important area within the field of construction safety management, namely behavior-based safety (BBS). This paper adopts and develops a management approach for safety improvements in construction site environments. A rigorous behavioral safety system and its intervention program was implemented and deployed on target construction sites. After taking a few weeks of safety behavior measurements, the project management team implemented the designed intervention and measurements were taken. Goal-setting sessions were arranged on-site with workers' participation to set realistic and attainable targets of performance. Safety performance measurements continued and the levels of performance and the targets were presented on feedback charts. Supervisors were asked to give workers recognition and praise when they acted safely or improved critical behaviors. Observers were requested to have discussions with workers, visit the site, distribute training materials to workers, and provide feedback to crews and display charts. They were required to talk to operatives in the presence of line managers. It was necessary to develop awareness and understanding of what was being measured. In the process, operatives learned how to act safely when conducting site tasks using the designed checklists. Current weekly scores were discussed in the weekly safety meetings and other operational site meetings with emphasis on how to achieve set targets. The reliability of the safety performance measures taken by the company's observers was monitored. A clear increase in safety performance level was achieved across all categories: personal protective equipment; housekeeping; access to heights; plant and equipment, and scaffolding. The research reveals that scores of safety performance at one project improved from 86% (at the end of 3rd week) to 92.9% during the 9th week. The results of intervention demonstrated large decreases in

  7. Preliminary safety and efficacy results with robotic high-intensity focused ultrasound : A single center Indian experience

    Directory of Open Access Journals (Sweden)

    Shashikant Mishra

    2011-01-01

    Full Text Available Background : There are no Indian data of high-intensity focused ultrasound (HIFU. Being an alternative, still experimental modality, reporting short-term safety outcome is paramount. Aims : This study was aimed at to assess the safety and short-term outcome in patients with prostate cancer treated by HIFU. Settings and Design : A retrospective study of case records of 30 patients undergoing HIFU between January 2008 to September 2010 was designed and conducted. Materials and Methods : The procedural safety was analyzed at 3 months. Follow-up consisted of 3 monthly prostate-specific antigen (PSA levels and transrectal biopsy if indicated. All the patients had a minimum follow-up of 6 months. Results : A mean prostate volume of 26.9 ± 8.5 cm 3 was treated in a mean time of 115 ± 37.4 min. There was no intraoperative complication. The postoperative pain visual analogue score at day 0 was 2.1 ± 1.9 and at day 1 was 0.4 ± 0.8 on a scale of 1-10. Mean duration of perurethral catheter removal was 3.9 days. The complications after treatment were: LUTS in seven patients, stress incontinence in two, stricture in two, and symptomatic urinary tract infection in five. Average follow-up duration was 10.4 months (range, 6-20 months. Mean time to obtain PSA nadir was 6 ± 3 months with a median PSA nadir value of 0.3 ng/ml. Two patients had positive prostatic biopsy in the localized (high risk group. Conclusions : HIFU was safe in carcinoma prostate patients. The short-term results were efficacious in localized disease. The low complication rates and favorable functional outcome support the planning of further larger studies.

  8. Key Techniques on the Preliminary Design Safety Evaluation of the Railway Passenger Station%铁路客站初步设计安全评价关键技术研究

    Institute of Scientific and Technical Information of China (English)

    王广宇; 李京

    2014-01-01

    Based on new features and complexity of safety shown in the construction and operation of railway passenger stations now, this paper introduces research background and status at home and abroad, explains the necessity of safety evaluation carried out at the preliminary design phase of railway passenger station, as well as the research significance of the railway passenger station. In addition to analysis of the research methods of safety evaluation home and aboard com-prehensively, it proposes key technologies for safety evaluation of preliminary design of railway passenger station that suit China's national situation, including theoretical study method used by experts systematic analysis, index system setting based on speciality and safety evaluation methods upon risk probability loss, etc. These key technologies can be used in the review procedure of document on safety subject for the preliminary design of railway passenger station, which pro-vides theory basis for further research in this field.%基于当代铁路旅客车站在建设和使用过程中,在安全方面表现出来的特点和复杂性,文章介绍了铁路客站安全评价的研究背景,国内外的研究现状,进而阐述了铁路客站初步设计阶段开展安全评价的必要性,以及本课题的研究意义,综合分析了国内外安全评价研究方法,研究并提出了适合我国国情的铁路客站初步设计阶段安全评价体系方面的若干关键技术,包括专家系统分析的理论研究方法、按专业分类别的指标体系设置和基于风险概率损失的安全评价模型等研究内容。铁路客站初步设计阶段安全评价关键技术可用在铁路客站初步设计文件安全专题的评审过程中,并为该领域进一步的研究应用提供理论基础。

  9. Preliminary studies on the optimization of countermeasures for agricultural areas

    Energy Technology Data Exchange (ETDEWEB)

    Rochedo, Elaine R.R.; Igreja, Eduardo; Barboza, Adriana E., E-mail: elainerochedo@gmail.com, E-mail: eduigreja@gmail.com, E-mail: adrianaebarboza@gmail.com [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil); Silva, Diogo N.G. da; Guimaraes, Jean R.D., E-mail: diogons@gmail.com, E-mail: jeanrdg@biof.ufrj.br [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Instituto de Biofisica Carlos Chagas Filho; Wasserman, Maria Angelica V., E-mail: mwasserman@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Perez, Daniel V. [Centro Nacional de Pesquisa de Solos (EMBRAPA), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    The assessment of remediation measures for rural areas is more complex than that for urban ones, due to the influence of large number of variables associated with climate, diet, farming practices and the type of soil. Thus, it is not possible to perform generic studies applicable to all types of area. Specific studies and surveys should be made in the areas most likely to contamination from a nuclear accident. Preliminary studies demonstrated that the different soil types in Brazil is more relevant to the ingestion dose than the regional differences in diets. Other studies have described the prioritization of areas and products for detailed survey on soil types and remediation procedures, for an accident at the NPP in Angra dos Reis, based on radiological and economic aspects. The most relevant product was milk, due to both its relevance to the intake and the loss of income for the counties. The contribution of milk to dose depends on the season of the year when the accident occurs, mainly due to the relative contribution of other items of the diet. The timing of the application of the countermeasure has an important effect on the dose reduction that can be achieved. For I-131, protective measures must be considered within the emergency phase in order to be effective. The main action on reducing ingestion doses is the removal of food items from diet, while providing clean food to the population. (author)

  10. Preliminary studies to determine the shelf life of HEPA filters

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, H.; Fretthold, J.K.; Rainer, F. [Lawrence Livermore National Laboratory, CA (United States)] [and others

    1995-02-01

    We have completed a preliminary study using filter media tests and filter qualification tests to investigate the effect of shelf-life on HEPA filter performance. Our media studies showed that the tensile strength decreased with age, but the data were not sufficient to establish a shelf-life. Thermogravimetric analyses demonstrated that one manufacturer had media with low tensile strength due to insufficient binder. The filter qualification tests (heated air and overpressure) conducted on different aged filters showed that filter age is not the primary factor affecting filter performance; materials and the construction design have a greater effect. An unexpected finding of our study was that sub-standard HEPA filters have been installed in DOE facilities despite existing regulations and filter qualification tests. We found that the filter with low tensile strength failed the overpressure test. The same filter had passed the heated air test, but left the filter so structurally weak, it was prone to blow-out. We recommend that DOE initiate a filter qualification program to prevent this occurrence.

  11. Caligula-Christ: Preliminary Study of a Parallel

    Directory of Open Access Journals (Sweden)

    Lorene M. Birden

    2010-01-01

    Full Text Available Caligula, at the very beginning of the Albert Camus play, conceives a very ambitious project; to surpass the gods and take their place in his empire, in order to decree impossibility. Camus has, however, gone a step further in developing the god-image of his main character through the incorporation of much Christian imagery into the scenes. This aspect of the play seems not to have been noticed by Camus scholars; there is no in-depth study of the use of this imagery. However, Camus scholar Patricia Johnson and the members of the Société des études camusiennes have noted the usefulness of the analysis presented here and the absence of it in previous research. This study, designated as “preliminary,” attempts to prompt further analyses of the question and offers different approaches. It proceeds by intertextual study of Caligula and the gospels (here referred to in Revised Standard Version and brings out aspects of the emperor’s intentions that expose a combination of perversion and similarity in relation to deity. It briefly outlines the sources of this parallel and the reasons for creating it, then details the parallels that show first the reversal of the image of Jesus, then the striking consonance. It ends with interpretations of the parallels and concludes with commentaries on the use of irony to create them.

  12. Liquid metal reactor development -Studies on safety measure of LMR coolant

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Sung Tae; Choi, Yoon Dong; Park, Jin Hoh; Kwon, Sun Kil; Choi, Jong Hyun; Cho, Byung Ryul; Kim, Tae Joon; Kwon, Sang Woon; Jung, Kyung Chae; Kim, Byung Hoh; Hong, Soon Bok; Jung, Ji Yung [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-07-01

    A study on the safety measures of LMR coolant showed the results as follows; 1. LMR coolant safety measure. A. Analysis and improvement of sodium fire code. B. Analysis of sodium fire phenomena. 2. Sodium fire aerosol characteristics. It was carried out conceptual design and basic design for sodium fire facility of medium size composed of sodium supply tank, sodium reactor vessel, sodium fire aerosol filter system and scrubbing column, and drain tank etc. 3. Sodium purification technology. A. Construction of calibration loop. (1) Design of sodium loop for the calibration of the equipment. (2) Construction of sodium loop including test equipments and other components. B. Na-analysis technology. (1) Oxygen concentration determination by the wet method. (2) Cover gas purification preliminary experiment. 4. The characteristics of sodium-water reaction. A. Analysis of the micro and small leak phenomena. (1) Manufacture of the micro-leak test apparatus. B. Analysis of large leak events. (1) Development of preliminary code for analysis of initial spike pressure. (2) Sample calculation and comparison with previous works. C. Development of test facility for large leak event evaluation. (1) Conceptional and basic design for the water and sodium-water test facility. D. Technology development for water leak detection system. (1) Investigations for the characteristics of active acoustic detection system. (2) Testing of the characteristics of hydrogen leak detection system. 171 figs, 29 tabs, 3 refs. (Author).

  13. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies.

    Science.gov (United States)

    Andrade, E L; Bento, A F; Cavalli, J; Oliveira, S K; Schwanke, R C; Siqueira, J M; Freitas, C S; Marcon, R; Calixto, J B

    2016-12-12

    The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through several steps, such as determination of drug availability (studies on pharmacokinetics), absorption, distribution, metabolism and elimination (ADME) and preliminary studies that aim to investigate the candidate safety including genotoxicity, mutagenicity, safety pharmacology and general toxicology. These preliminary studies generally do not need to comply with GLP regulations. These studies aim at investigating the drug safety to obtain the first information about its tolerability in different systems that are relevant for further decisions. There are, however, other studies that should be performed according to GLP standards and are mandatory for the safe exposure to humans, such as repeated dose toxicity, genotoxicity and safety pharmacology. These studies must be conducted before the Investigational New Drug (IND) application. The package of non-clinical studies should cover all information needed for the safe transposition of drugs from animals to humans, generally based on the non-observed adverse effect level (NOAEL) obtained from general toxicity studies. After IND approval, other GLP experiments for the evaluation of chronic toxicity, reproductive and developmental toxicity, carcinogenicity and genotoxicity, are carried out during the clinical phase of development. However, the necessity of performing such studies depends on the new drug clinical application purpose.

  14. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies

    Directory of Open Access Journals (Sweden)

    E.L. Andrade

    Full Text Available The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through several steps, such as determination of drug availability (studies on pharmacokinetics, absorption, distribution, metabolism and elimination (ADME and preliminary studies that aim to investigate the candidate safety including genotoxicity, mutagenicity, safety pharmacology and general toxicology. These preliminary studies generally do not need to comply with GLP regulations. These studies aim at investigating the drug safety to obtain the first information about its tolerability in different systems that are relevant for further decisions. There are, however, other studies that should be performed according to GLP standards and are mandatory for the safe exposure to humans, such as repeated dose toxicity, genotoxicity and safety pharmacology. These studies must be conducted before the Investigational New Drug (IND application. The package of non-clinical studies should cover all information needed for the safe transposition of drugs from animals to humans, generally based on the non-observed adverse effect level (NOAEL obtained from general toxicity studies. After IND approval, other GLP experiments for the evaluation of chronic toxicity, reproductive and developmental toxicity, carcinogenicity and genotoxicity, are carried out during the clinical phase of development. However, the necessity of performing such studies depends on the new drug clinical application purpose.

  15. A Preliminary Study on Gender Differences in Studying Systems Analysis and Design

    Science.gov (United States)

    Lee, Fion S. L.; Wong, Kelvin C. K.

    2017-01-01

    Systems analysis and design is a crucial task in system development and is included in a typical information systems programme as a core course. This paper presented a preliminary study on gender differences in studying a systems analysis and design course of an undergraduate programme. Results indicated that male students outperformed female…

  16. Wastewater characterization of IPEN facilities - a preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Monteiro, Lucilena R.; Goncalves, Cristina; Terazan, Wagner R.; Cotrim, Marycel E.B.; Pires, Maria Aparecida F., E-mail: lrmonteiro@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    As part of IPEN's Environmental Monitoring Program, wastewater sample collection and analysis was implemented on a daily basis. CQMA- Centro de Quimica e Meio Ambiente was responsible for the determination of total, fixed and volatile solids, pH, metals (as Al, Sb, Ba, Cd, Pb, Co, Cu, Cr, Hg, Mo, Ni, Ag, Na, Zn, Ca, Mg, Be, Sn, Li, K, Sr, Ti and V), semimetals (As, B, Se and Si) and anions (such as chloride, nitrate, sulfate and fluoride). The results were compared to the legal values established by the Sao Paulo State regulation 8,468/76, which defines the maximum permitted values for most of the studied substances in wastewater, aiming its releasing in public wastewater treatment system. The evaluation of this parameters concentration on Ipen's effluent implies that 50% of the wastewater corresponds to organic matter due to the sanitary load and inorganic macro elements, mainly as sodium, potassium, calcium. The only parameter not found in accordance with Brazilian legislation was pH in four out of the one hundred and seven samples collected throughout 2009 (2.8% of the samples analyzed). This preliminary study showed the effluents generated at Ipen's facility is characterized by the presence of organic matter and macro elements, commonly found in sanitary wastewater and it is in compliance with Sao Paulo regulations. (author)

  17. Effects of gamma radiation on bee venom: preliminary studies

    Energy Technology Data Exchange (ETDEWEB)

    Costa, H.; Boni-Mitake, M.; Souza, C.F.; Rogero, J.R. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil). Div. de Radiobiologia

    1999-11-01

    Africanized honeybees are very common insects in Brazil and frequently cause accidents followed by important immunological reactions and even deaths. Their venoms are composed of a complex mixture of substances of general biological actions. several works utilizing ionizing radiation showed that it is able to modify protein structures, and successfully detoxify snake venoms toxins, although maintaining its immunological properties. The main objective of this paper was to study the effects of gamma radiation on bee venom, regarding some biochemical and toxicological aspects. Africanized Apis melllifera whole venom (2 mg/ml) in 0.15 M Na Cl solution was irradiated with 2 kGy in a {sup 60} Co source. Preliminary studies has been carried out in order to identify some biochemical changes after irradiation. Concerning this, irradiated and native venom were submitted to a molecular exclusion chromatography (Sephadex G-100), UV absorption spectrum and protein concentration analysis. It could be seen that irradiated bee venom spectrum presented differences when compared to native bee venom, suggesting that some structural alterations has occurred. Protein concentration and chromatography profiles were not changes after irradiation. In order to evaluate the toxicity a lethality assay (L D{sub 50}) has been performed with both venoms, and irradiated venom showed to be less toxic than native one. (author) 23 refs., 3 figs., 1 tab.

  18. Thulium-170-labeled microparticles for local radiotherapy: preliminary studies.

    Science.gov (United States)

    Polyak, Andras; Das, Tapas; Chakraborty, Sudipta; Kiraly, Reka; Dabasi, Gabriella; Joba, Robert Peter; Jakab, Csaba; Thuroczy, Julianna; Postenyi, Zita; Haasz, Veronika; Janoki, Gergely; Janoki, Gyozo A; Pillai, Maroor R A; Balogh, Lajos

    2014-10-01

    The present article describes the preparation, characterization, and biological evaluation of Thulium-170 ((170)Tm) [T1/2 = 128.4 days; Eβmax = 968 keV; Eγ = 84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. (170)Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (> 99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (< 8% of I.D.) of the instilled particles. The majority of leaked radiocolloid particles were found in inguinal lymph nodes during the 9 months of follow-up. All the animals tolerated the treatment well; the compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy.

  19. A Preliminary Study of Bryophytes in Enggano Island, Bengkulu, Indonesia

    Directory of Open Access Journals (Sweden)

    Ainun Nadhifah

    2016-09-01

    Full Text Available Enggano Island is one of the outer islands  that belongs to the Province of Bengkulu. Furthermore, there is very limited information about the diversity of bryophyte from Sumatera, especially in lowland forest, Enggano Island. The aim of this research was to provide the initial information related to the diversity of bryophytes in Enggano. The research was conducted in six forests i.e. primary, secondary and degraded forests. The results showed that 32 number of collection from 14 families, 21 genera, and 32 species were identified. Leceuneaceae was common family for liverworts while the mosses family was dominated by Hypnaceae. None of the hornworts were found in this study. Some species identified (Taxyphyllum sp., Vesicularia sp., Riccardia sp., and Thuidium sp. have the potential benefit and biological activity. Two genera were new records to Sumatra, Gongylanthus, and Symphyogyna. Moreover, Gongylanthus sp. and Symphyogyna sp. have important records related to the habitat.How to CiteNadhifah, A., & Surya, M. I. (2016. A Preliminary Study of Bryophytes in Enggano Island, Bengkulu, Indonesia. Biosaintifika: Journal of Biology & Biology Education, 8(2, 201-205.

  20. Preliminary Study of the Gravimetric Local Geoid Model in Jordan:

    Directory of Open Access Journals (Sweden)

    A. Al-Zoubi

    2007-06-01

    Full Text Available Recently, there is an increased interest in studying and defining the Local and Regional Geoid Model worldwide, due to its importance in geodetic and geophysics applications. The use of the Global Positioning System (GPS is internationally growing, yet the lack of any Geoid Model for Jordan has limited the use of GPS for geodetic applications. Therefore, this work aims to present the preliminary results that we propose for The Gravimetric Jordanian Geoid Model (GeoJordan. The model is created using gravimetric data and the GravSoft program. The validation of this model is done by using GPS measurements and precise leveling at Amman area. However, a comparison between the Global Geopotential Models OSU91A and EGM96 showed great discrepancies through the presented results. Also, presenting the approach used to obtain the orthometric height from GPS ellipsoidal height measurements. Nevertheless, the error margin; obtained in this initial study of the GeoJordan after fitting the data with GPS/leveling measurement; is about (10cm, in tested area whereas the standard error of the created model is about (40cm.

  1. SAFETY

    CERN Multimedia

    M. Plagge, C. Schaefer and N. Dupont

    2013-01-01

    Fire Safety – Essential for a particle detector The CMS detector is a marvel of high technology, one of the most precise particle measurement devices we have built until now. Of course it has to be protected from external and internal incidents like the ones that can occur from fires. Due to the fire load, the permanent availability of oxygen and the presence of various ignition sources mostly based on electricity this has to be addressed. Starting from the beam pipe towards the magnet coil, the detector is protected by flooding it with pure gaseous nitrogen during operation. The outer shell of CMS, namely the yoke and the muon chambers are then covered by an emergency inertion system also based on nitrogen. To ensure maximum fire safety, all materials used comply with the CERN regulations IS 23 and IS 41 with only a few exceptions. Every piece of the 30-tonne polyethylene shielding is high-density material, borated, boxed within steel and coated with intumescent (a paint that creates a thick co...

  2. SAFETY

    CERN Multimedia

    C. Schaefer and N. Dupont

    2013-01-01

      “Safety is the highest priority”: this statement from CERN is endorsed by the CMS management. An interpretation of this statement may bring you to the conclusion that you should stop working in order to avoid risks. If the safety is the priority, work is not! This would be a misunderstanding and misinterpretation. One should understand that “working safely” or “operating safely” is the priority at CERN. CERN personnel are exposed to different hazards on many levels on a daily basis. However, risk analyses and assessments are done in order to limit the number and the gravity of accidents. For example, this process takes place each time you cross the road. The hazard is the moving vehicle, the stake is you and the risk might be the risk of collision between both. The same principle has to be applied during our daily work. In particular, keeping in mind the general principles of prevention defined in the late 1980s. These principles wer...

  3. Design and proof of function of a closure system for an HLW-repository in rock salt. Results of the preliminary safety analysis for the Gorleben site (VSG)

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Hoeppe, Nina; Breustedt, Michael; Engelhardt, Hans-Joachim; Wolf, Johanna [DBE Technology GmbH, Peine (Germany); Buhmann, Dieter; Czaikowski, Oliver; Herbert, Horst-Juergen; Wieczorek, Klaus; Xie, Mingliang [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH, Braunschweig (Germany)

    2015-07-01

    Within the preliminary safety analysis for the Gorleben site (VSG), a closure system was designed in order to complement the containment providing rock zone (CRZ) by sealing and backfilling measures. The design procedure as well as the technical proof of function was mainly performed according to standard procedures in civil engineering. In the context of VSG, rough individual technical proofs of several measures were carried out. Meanwhile, this gap has been closed by subsequent investigations. Altogether the results of all the individual technical proofs of function indicate that safe containment of radioactive waste is a realistic possibility at the Gorleben site.

  4. ECG response of koalas to tourists proximity: a preliminary study.

    Directory of Open Access Journals (Sweden)

    Yan Ropert-Coudert

    Full Text Available Koalas operate on a tight energy budget and, thus, may not always display behavioral avoidance reaction when placed in a stressful condition. We investigated the physiological response of captive koalas Phascolarctos cinereus in a conservation centre to the presence of tourists walking through their habitat. We compared, using animal-attached data-recorders, the electrocardiogram activity of female koalas in contact with tourists and in a human-free area. One of the koalas in the tourist zone presented elevated heart rate values and variability throughout the recording period. The remaining female in the exhibit area showed a higher field resting heart rates during the daytime than that in the isolated area. In the evening, heart rate profiles changed drastically and both the koalas in the exhibit and in the tourist-free zones displayed similar field resting heart rates, which were lower than those during the day. In parallel, the autonomic nervous systems of these two individuals evolved from sympathetic-dominant during the day to parasympathetic-dominant in the evening. Our results report ECG of free-living koalas for the first time. Although they are preliminary due to the difficulty of having sufficient samples of animals of the same sex and age, our results stress out the importance of studies investigating the physiological reaction of animals to tourists.

  5. Textual appropriation in engineering master's theses: a preliminary study.

    Science.gov (United States)

    Eckel, Edward J

    2011-09-01

    In the thesis literature review, an engineering graduate student is expected to place original research in the context of previous work by other researchers. However, for some students, particularly those for whom English is a second language, the literature review may be a mixture of original writing and verbatim source text appropriated without quotations. Such problematic use of source material leaves students vulnerable to an accusation of plagiarism, which carries severe consequences. Is such textual appropriation common in engineering master's writing? Furthermore, what, if anything, can be concluded when two texts have been found to have textual material in common? Do existing definitions of plagiarism provide a sufficient framework for determining if an instance of copying is transgressive or not? In a preliminary attempt to answer these questions, text strings from a random sample of 100 engineering master's theses from the ProQuest Dissertations and Theses database were searched for appropriated verbatim source text using the Google search engine. The results suggest that textual borrowing may indeed be a common feature of the master's engineering literature review, raising questions about the ability of graduate students to synthesize the literature. The study also illustrates the difficulties of making a determination of plagiarism based on simple textual similarity. A context-specific approach is recommended when dealing with any instance of apparent copying.

  6. Lymphangiogenesis in Classical Hodgkin Lymphoma - Preliminary Study with Clinicopathological Correlations

    Science.gov (United States)

    Benharroch, Daniel; Prinsloo, Isebrand; Gopas, Jacob; Lazarev, Irena

    2016-01-01

    A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice. Of the 57 hot spots thus identified, we chose 15 at random for photography, microvessel counting and image analysis. We determined the mean perimeter, surface area, major axis length and complexity factor for each hot spot and correlated them with clinical and biological features of classical Hodgkin lymphoma. No correlations were found with clinical features. No associations were noted with the standard immuno-markers of classical Hodgkin lymphoma. However, significant inverse correlations were shown with pRb, BAX and IκB-α expression. The mean lymphatic major axis length was inversely correlated with the complexity factor. Last, we carried out an additional clinicopathological correlation of the expression of pRb, BAX and IκB-α in a cohort of classical Hodgkin lymphoma patients previously published. PMID:27877228

  7. Studying the anthropogenic radionuclides in Puerto Rico: Preliminary Result

    Science.gov (United States)

    Ithier-Guzmán, W.; Pyrtle, A. J.; Smoak, J.

    2004-12-01

    Local introduction of anthropogenic radionuclides to Puerto Rico's terrestrial and aquatic environments began in 1962 as a result of US government-sponsored research activities. Some of the earlier experiments examined the effects of radiation in tropical rainforests and the potential of superheated boiling nuclear reactor technology. More recent activities involved the use of depleted uranium during military exercises on Vieques. While the presence of radionuclides in Puerto Rico is documented, little research has been done to assess the environmental impact of this anthropogenic material. After entering Puerto Rico's environment, it is likely that some radionuclides are transported away from initial introduction sites. It is important that the distributions and behavior of radionuclides in Puerto Rico be determined. As such an investigation of this material throughout Puerto Rico was initiated. Sediment Cs-137 and Pb-210 activities, as well as ancillary geochemistry data are presented. These preliminary findings will be utilized as part of an ongoing study to determine radionuclide distributions and behaviors, with respect to aquatic geochemistry and dominant transport processes.

  8. Preliminary Design Study of the Hollow Electron Lens for LHC

    CERN Document Server

    Perini, Diego; CERN. Geneva. ATS Department

    2017-01-01

    A Hollow Electron Lens (HEL) has been proposed in order to improve performance of halo control and collimation in the Large Hadron Collider in view of its High Luminosity upgrade (HL-LHC). The concept is based on a beam of electrons that travels around the protons for a few meters. The electron beam is produced by a cathode and then guided by a strong magnetic field generated by a set of superconducting solenoids. The first step of the design is the definition of the magnetic fields that drive the electron trajectories. The estimation of such trajectories by means of a dedicated MATLAB® tool is presented. The influence of the main geometrical and electrical parameters are analysed and discussed. Then, the main mechanical design choices for the solenoids, cryostats gun and collector are described. The aim of this paper is to provide an overview of the preliminary design of the Electron Lens for LHC. The methods used in this study also serve as examples for future mechanical and integration designs of similar ...

  9. Preliminary Study on Diverse Carbon Utilization by Transformant Aspergillus niger

    Directory of Open Access Journals (Sweden)

    S. H. Mohammad

    2012-01-01

    Full Text Available Aspergillus niger have been widely recognized as producer of metabolites and reported as good expression hosts for homologous and heterologous proteins. For recombinant expression systems, nature of metabolite production would change when the expression host system is modified via plasmid development. In order to study the diversity of carbon utilization of transformant A.niger and their relation to specific carbon sources that could trigger mannanase production, a new screening system was introduced using Biolog technique to evaluate the growth of the transformant performed on 95 carbon sources. As a result, the transformed A.niger were found able to utilize dextrin and other 27 carbohydrates with majority preferred carbohydrates were identified as monosaccharide, oligosaccharides and some sugar alcohols as the best chosen carbon sources for growth. The relative simplicity and global carbon sources underlying in the biolog system for screening of carbon source make it as a useful tool for the preliminary screening and identification of carbon sources in order to select the best carbon source for medium development.

  10. Calibration Study and Preliminary Results of PRad Experiment

    Science.gov (United States)

    Levillain, Maxime; PRad Collaboration

    2016-09-01

    The latest measurements of the proton radius through muonic hydrogen Lamb shift show a discrepancy of 7 σ from a global analysis of standard hydrogen Lamb shift and elastic ep -scattering. In order to understand this proton radius puzzle, the PRad experiment successfully took in last June some elastic ep -scattering data at very low Q2 (2 .10-4 to 10-1 GeV2) with very accurate angle and energy measurements to minimize the systematic uncertainties. Before measuring the cross-sections that will be used to extract the electromagnetic form factor GE(Q2) and the proton radius, a very careful calibration of the electromagnetic calorimeter (HyCal) must be performed to get a good energy resolution and separate ep -events from M øller events especially at low angle. We will present an extended study of the electromagnetic calorimeter calibration of this experiment as well as some preliminary results on ep - and ee -scattering processes extracted from the data. The PRad experiment is supported in part by NSF MRI Award PHY-1229153.

  11. A preliminary study looking at parental emotions following cochlear implantation.

    Science.gov (United States)

    Anagnostou, Flora; Graham, John; Crocker, Susan

    2007-06-01

    This preliminary research investigated the emotions of parents with cochlear implanted children. The object for the research was first to compare four emotions engendered in parents of deaf children before and after cochlear implantation. Second, to monitor changes in these emotions during a period of up to four years after implantation. Third, to see whether any of the emotions studied was significantly more prominent than the others, and fifth to identify any differences in emotions that were related to the gender of parents. A self-report questionnaire was given to 112 participants of whom 53 replied. There were equal groups of parents in two categories, those with children up to two years after implantation, and those two to four years after implantation. The responses were interpreted using parametric statistics. The results highlight that grief is the strongest emotional condition that parents experience before and up to two years after implantation, alongside family adjustments. Parents of the up to two years after implantation group generally have stronger feelings and are less satisfied than parents in the over two years implanted group. Finally, fathers use denial more than mothers. Considerations for future research and implications for paediatric cochlear implant teams will be discussed.

  12. ECG response of koalas to tourists proximity: a preliminary study.

    Science.gov (United States)

    Ropert-Coudert, Yan; Brooks, Lisa; Yamamoto, Maki; Kato, Akiko

    2009-10-12

    Koalas operate on a tight energy budget and, thus, may not always display behavioral avoidance reaction when placed in a stressful condition. We investigated the physiological response of captive koalas Phascolarctos cinereus in a conservation centre to the presence of tourists walking through their habitat. We compared, using animal-attached data-recorders, the electrocardiogram activity of female koalas in contact with tourists and in a human-free area. One of the koalas in the tourist zone presented elevated heart rate values and variability throughout the recording period. The remaining female in the exhibit area showed a higher field resting heart rates during the daytime than that in the isolated area. In the evening, heart rate profiles changed drastically and both the koalas in the exhibit and in the tourist-free zones displayed similar field resting heart rates, which were lower than those during the day. In parallel, the autonomic nervous systems of these two individuals evolved from sympathetic-dominant during the day to parasympathetic-dominant in the evening. Our results report ECG of free-living koalas for the first time. Although they are preliminary due to the difficulty of having sufficient samples of animals of the same sex and age, our results stress out the importance of studies investigating the physiological reaction of animals to tourists.

  13. VEGF Expression in Patellar Tendinopathy: A Preliminary Study

    Science.gov (United States)

    Lian, Øystein; Bahr, Roald; Hart, David A.; Duronio, Vincent

    2008-01-01

    Vascular function and angiogenesis are regulated by vascular endothelial growth factor-A (VEGF). The purpose of this preliminary study was to address the following questions: Is VEGF expression in the patellar tendon more prevalent in patients with patellar tendinopathy than in individuals with normal, pain-free patellar tendons? Which cell populations express VEGF in normal and tendinopathic tendon? Is there a difference in symptom duration between VEGF+ and VEGF− tendons? We collected patellar tendon tissue from 22 patients undergoing open débridement of the patellar tendon and from 10 patients undergoing intramedullary nailing of the tibia. VEGF expression was assessed immunohistochemically. Relevant inflammatory and repair cell types were immunolabeled. VEGF expression was absent from control tendons, but was present in a subset of patients with histopathological evidence of angiofibroblastic tendinosis. VEGF was expressed in the intimal layer of tendon vessels, but was absent in other cell types. Patients demonstrating VEGF expression in the patellar tendon had a shorter symptom duration (12 ± 7.8 months) than patients with no detectable VEGF (32.8 ± 23.5 months). VEGF may contribute to the vascular hyperplasia that is a cardinal feature of symptomatic tendinosis, particularly in cases with more recent onset. PMID:18459027

  14. The relationship between team climate and interprofessional collaboration: Preliminary results of a mixed methods study.

    Science.gov (United States)

    Agreli, Heloise F; Peduzzi, Marina; Bailey, Christopher

    2017-03-01

    Relational and organisational factors are key elements of interprofessional collaboration (IPC) and team climate. Few studies have explored the relationship between IPC and team climate. This article presents a study that aimed to explore IPC in primary healthcare teams and understand how the assessment of team climate may provide insights into IPC. A mixed methods study design was adopted. In Stage 1 of the study, team climate was assessed using the Team Climate Inventory with 159 professionals in 18 interprofessional teams based in São Paulo, Brazil. In Stage 2, data were collected through in-depth interviews with a sample of team members who participated in the first stage of the study. Results from Stage 1 provided an overview of factors relevant to teamwork, which in turn informed our exploration of the relationship between team climate and IPC. Preliminary findings from Stage 2 indicated that teams with a more positive team climate (in particular, greater participative safety) also reported more effective communication and mutual support. In conclusion, team climate provided insights into IPC, especially regarding aspects of communication and interaction in teams. Further research will provide a better understanding of differences and areas of overlap between team climate and IPC. It will potentially contribute for an innovative theoretical approach to explore interprofessional work in primary care settings.

  15. Platform for dynamic tests: preliminary studies, design and construction

    Directory of Open Access Journals (Sweden)

    J. E. Campuzano

    . The platform was built and has been done a preliminary experimental study to obtain the first natural frequencies.

  16. Bio-Contamination Control for Spacesuit Garments - A Preliminary Study

    Science.gov (United States)

    Rhodes, Richard; Korona, Adam; Orndoff, Evelyn; Ott, Mark; Poritz, Darwin

    2010-01-01

    This paper outlines a preliminary study to review, test, and improve upon the current state of spacesuit bio-contamination control. The study includes an evaluation of current and advanced suit materials, ground and on-orbit cleaning methods, and microbial test and analysis methods. The first aspect of this study was to identify potential anti-microbial textiles and cleaning agents, and to review current microbial test methods. The anti-microbial cleaning agent and textile market survey included a review of current commercial-off-the-shelf (COTS) products that could potentially be used as future space flight hardware. This review included replacements for any of the softgood layers that may become contaminated during an extravehicular activity (EVA), including the pressure bladder, liquid cooling garment, and ancillary comfort undergarment. After a series of COTS anti-microbial textiles and clean ing agents were identified, a series of four tests were conducted: (1) a stacked configuration test that was conducted in order to review how bio-contamination would propagate through the various suit layers, (2) a individual materials test that evaluated how well each softgood layer either promoted or repressed growth, (3) a cleaning agent test that evaluated the efficacy on each of the baseline bladders, and (4) an evaluation of various COTS anti-microbial textiles. All antimicrobial COTS materials tested appeared to control bacteria colony forming unit (CFU) growth better than the Thermal Comfort Undergarment (TCU) and ACES Liquid Cooling Garment (LCG)/EMU Liquid Cooling Ventilation Garment (LCVG) materials currently in use. However, a comparison of fungi CFU growth in COTS to current suit materials appeared to vary per material. All cleaning agents tested in this study appeared to inhibit the level of bacteria and fungi growth to acceptable levels for short duration tests. While several trends can be obtained from the current analysis, a series of test improvements are

  17. Review of SKB's preliminary safety evaluations for Forsmark and Laxemar; Myndigheternas granskning av SKB:s preliminaera saekerhetsbedoemningar foer Forsmark och Laxemar

    Energy Technology Data Exchange (ETDEWEB)

    Norden, Maria; Wallberg, Petra; Wiebert, Anders; Dverstorp, Bjoern; Shulan Xu (Swedish Radiation Protection Authority, Stockholm (Sweden)); Toverud, Oeivind; Stroemberg, Bo; Kautsky, Fritz; Simic, Eva (Swedish Nuclear Power Inspectorate, Stockholm (Sweden))

    2008-01-15

    This report presents SKI's and SSI's review of SKB's preliminary safety evaluations for Forsmark and Laxemar. The purpose of the review is to assess if the extent of SKB's initial site investigations are sufficient and if they are performed with adequate quality and also if they comprise the data that is needed for future safety analysis. To meet the request from the municipalities where site investigations are performed the authorities have also attempted to elucidate if a site has such obvious weakness that it probably will not comply with authority regulations. The target groups for the review are the municipalities in Oskarshamn and Oesthammar, and SKB

  18. Blastocyst cryopreservation using solid surface vitrification: A preliminary study

    Directory of Open Access Journals (Sweden)

    Mohan S Kamath

    2011-01-01

    Full Text Available Objective: The objective was to evaluate the effectiveness of a blastocyst cryopreservation program using solid surface vitrification. Setting: This study took place in a university teaching hospital. Study Design: Retrospective observational study. Materials and Methods: Women undergoing frozen embryo transfer cycles over a 4-year period between 2006 and 2010 were studied. The cryopreservation policy followed was a vitrification protocol performed at the blastocyst stage, using a solid surface (nonimmersion method. The post-thaw survival rate, implantation rate, clinical pregnancy rate, live birth rate, and neonatal outcome were recorded. Results: Eighty-one women underwent 86 frozen embryo transfer cycles. Of the 240 blastocysts warmed, 204 survived giving a cryosurvival rate of 85% (204/240. The clinical pregnancy, implantation, miscarriage, ongoing pregnancy, and live birth rates per transfer were 47%, 29%, 12%, 16%, and 23% respectively. Of the 20 live births, there were 16 singletons and 4 twins. Eleven boys and 13 girls were delivered with no major or minor abnormality detected. Conclusion(s: The blastocyst vitrification protocol using the solid surface method is effective with results comparable to fresh blastocyst transfers. While retaining the rapid cooling effect, the nonimmersion technique eliminates the risk of contamination and disease transmission. Larger studies with long-term follow-up data would further confirm the efficacy and safety of this method of vitrification.

  19. Bacteriuria and safety of female urodynamic studies.

    Science.gov (United States)

    Dass, Anil Krishna; Lo, Tsia-Shu; Khanuengkitkong, Siwatchaya; Tan, Yiap-Loong

    2013-04-01

    Our aim was to study the incidence of bacteriuria after urodynamic studies (UDS) and prevalence of asymptomatic bacteriuria before UDS. In this prospective study between March and September 2011, 140 women undergoing UDS were subjected to urine culture before the investigation. Urine was collected aseptically with a sterile catheter transurethrally. Multichannel UDS were performed 3-5 days after urine collection. Prophylactic antibiotics were not administered to these women. A second urine sample was collected within 5-7 days after UDS. Significant bacteriuria was defined as 10(2) colony-forming units (cfu)/ml or more of a single organism cultured. Thirty (21.4 %) women had asymptomatic bacteriuria before UDS and were excluded from the main study group. Among the 110 women in the study group, 4 (3.6 %) acquired infection after UDS. Three grew organisms found in the vagina (group B Streptococcus and yeast-like organism) and one grew Proteus mirabilis. Age 60 years and above is a significant risk factor. In contrast to the study group, among 30 women who had infection before UDS, Escherichia coli was the commonest pathogen in 19 (63.3 %) and 30 % had diabetes. Eleven (36.7 %) had persistent infection after UDS and the rest resolved spontaneously. In addition, no other related complication was observed on the UDS. This study shows that risk of post UDS bacteriuria is low in women and screening for vaginal infections may be necessary before UDS. Women over 60 years old are significantly at risk of infection. Bacteriuria is nevertheless mostly asymptomatic and transient in nature.

  20. Analysis Study of Survey for Safety and Efficacy of Pharmacopuncture

    Directory of Open Access Journals (Sweden)

    Hong Kwon-eui

    2010-09-01

    Full Text Available This study was done in order to present clinical trial method for safety and efficacy of Pharmacopuncture. The results were summarized as follow:Objective : The purpose of this study is to verify about safety and effectiveness of pharmacopuncture. Methods : We use questionnaire created by expert group. Survey was conducted to target clinicians who using pharmacopuncture more then 5 years. Results & Conclusion : Pharmacopuncture is effective. and that is widely used in the musculoskeletal diseases. but treatment method has not been organized to objectivity. Some pharmacopuncture causes specific symptoms, but no serious side effects. Generally, pharmacopuncture is effective and safety. * This study is performed under the Research and Development Project of Korean Pharmacopuncture Institiute(2010’s sponsorship.

  1. Quality management of pharmacology and safety pharmacology studies

    DEFF Research Database (Denmark)

    Spindler, Per; Seiler, Jürg P

    2002-01-01

    Pharmacology has traditionally been excluded from the mandatory application of good laboratory practice (GLP) principles. Consensus has been reached through the process of the International Conference on Harmonisation (ICH, Topic S7A) with regard to the definitions of the different types...... to encourage a positive attitude among researchers and academics towards these lines, whenever possible. GLP principles applied to the management of non-clinical safety studies are appropriate quality standards when studies are used in the context of protecting public health, and these quality standards...... be prepared to exercise flexibility in their requirement for GLP compliance, however, if non-clinical studies used in human safety assessment are not formally in compliance with the principles of GLP, regulatory acceptance may not be guaranteed. Historically, the application of formal GLP standards in safety...

  2. Progress in preliminary studies at Ottana Solar Facility

    Science.gov (United States)

    Demontis, V.; Camerada, M.; Cau, G.; Cocco, D.; Damiano, A.; Melis, T.; Musio, M.

    2016-05-01

    The fast increasing share of distributed generation from non-programmable renewable energy sources, such as the strong penetration of photovoltaic technology in the distribution networks, has generated several problems for the management and security of the whole power grid. In order to meet the challenge of a significant share of solar energy in the electricity mix, several actions aimed at increasing the grid flexibility and its hosting capacity, as well as at improving the generation programmability, need to be investigated. This paper focuses on the ongoing preliminary studies at the Ottana Solar Facility, a new experimental power plant located in Sardinia (Italy) currently under construction, which will offer the possibility to progress in the study of solar plants integration in the power grid. The facility integrates a concentrating solar power (CSP) plant, including a thermal energy storage system and an organic Rankine cycle (ORC) unit, with a concentrating photovoltaic (CPV) plant and an electrical energy storage system. The facility has the main goal to assess in real operating conditions the small scale concentrating solar power technology and to study the integration of the two technologies and the storage systems to produce programmable and controllable power profiles. A model for the CSP plant yield was developed to assess different operational strategies that significantly influence the plant yearly yield and its global economic effectiveness. In particular, precise assumptions for the ORC module start-up operation behavior, based on discussions with the manufacturers and technical datasheets, will be described. Finally, the results of the analysis of the: "solar driven", "weather forecasts" and "combined storage state of charge (SOC)/ weather forecasts" operational strategies will be presented.

  3. A preliminary magnetic study of Sawa lake sediments, Southern Iraq

    Science.gov (United States)

    Ameen, Nawrass

    2016-04-01

    A preliminary magnetic study combined with chemical analyses was carried out in Sawa Lake in Al-Muthanna province, southern Iraq, about 22 km south west of Samawa city (31°18'48.80"N, 45°0'25.25"E). The lake is about 4.74 km length, 1.75 km width and 5.5 m height, it is surrounded by a salt rim which is higher than the lake water by about 2.8 m and sea water by about 18.5 m (Naqash et al., 1977 in Hassan, 2007). The lake is an elongated closed basin with no surface water available to it, it may be fed by groundwater of the Euphrates and Dammam aquifers through system of joints and cracks. This study aims to investigate the concentrations of selected heavy metals as pollutants and magnetic susceptibility (MS) and other magnetic properties of sediment samples from fifty sites collected from the bottom of the lake, the study area lies in an industrial area. The results show spatial variations of MS with mean value of about 4.58 x 10-8 m3 kg-1. Scanning electron microscopy and magnetic mineralogy parameters indicate the dominance of soft magnetic phase like magnetite and presence of hard magnetic phase like hematite. Spatial variations of MS combined with the concentrations of heavy metals suggests the efficiency of magnetic methods as effective, inexpensive and non-time consuming method to outlining the heavy metal pollution. References: Hassan W.F., 2007. The Physio-chemical characteristic of Sawa lake water in Samawa city-Iraq. Marine Mesopotamica, 22(2), 167-179.

  4. [Oral contraceptives: recent safety studies (author's transl)].

    Science.gov (United States)

    Edgren, R A

    1983-09-01

    Considerable research evidence now exists to suggest that the risks of oral contraceptive (OC) use were seriously overestimated in earlier work. Because experimentation in medicine is never possible in the rigorous sense in which it is employed in basic sciences, other sources of information must be substituted. Information on the dangers of OC use has come from anecdotal reports, retrospective case control studies, prospective cohort studies, and statistical analyses of deaths, each source being associated with specific problems of interpretation. Recent findings of the Royal College of General Practitioners, the Walnut Creek Study, and the Oxford Study have suggested a lowered incidence of malignant neoplasms in OC than in IUD or diaphragm users; a reduced incidence of breast cancer although the relationship did not consistently achieve statistical significance, and a reduced incidence of ovarian and endometrial cancer. The risks of cervical cancer among OC users appeared slightly higher but disappeared when sexual behavior was controlled. Despite much concern with the possibility of postpill amenorrhea and perhaps sterility among women discontinuing OC use, it now appears that after 2 years there is no difference in the fertility of women who have discontinued use of OCs, IUDs, or diaphragms. Use of OCs as a contraceptive before pregnancy does not appear to be associated with fetal malformations, spontaneous abortion, or perinatal mortality, and the inadvertent use of OCs in early pregnancy is apparently associated with only a very slight risk of anomalies. Recent studies of cardiovascular disease risks indicate that the relative risks of cardiovascular disease among OC users have been greatly exaggerated, especially when smoking is taken into account. Various studies of mortality data have failed to establish a link between OC use and excess mortality from cardiovascular disease.

  5. Study on categorization of the safety design evaluation event

    Energy Technology Data Exchange (ETDEWEB)

    Kurisaka, Kenichi; Kani, Yoshio [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-05-01

    In order to make a FBR practicable, it is important to make rational categorization of a safety design evaluation event. In this study, for the purpose of providing useful information into the event categorization, we developed the occurrence frequency data of various abnormal events, presented a proposal of the event categorization primarily based on the occurrence frequency and examined efficiency of the proposal. We researched and analyzed abnormal event instances of foreign and domestic FBR plants and of domestic light water reactor power plants. On the basis of the analysis, the failure occurrence frequency of the protection system (PS) in the FBR model plants with electric power production of 600MW and 1,000MW was quantified. Making use of results of probabilistic safety assessment study, loss-of-function probability of the mitigation system (MS) was quantified. Some of combinations of PS failure and loss of MS function were selected and their occurrence frequencies were quantified. We examined problems in the current categorization of the safety design evaluation event and presented a new proposal of the event categorization. Merits of the new proposal are to have divided the current category of `accident` into `small accident` and `rare accident`, explicitly to treat a multiple failure event not as a collateral analysis condition of supposing `a single failure` but as an event to be evaluated, and to have added a category for the event which is beyond design base, but should be supposed to evaluate depth of the safety design in terms of defense-in-depth. Some candidates of the safety design evaluation event were identified and applied to the new proposal. In comparison with the current categorization, we obtained perspective that it was possible to evaluate the safety design more in detail and effectively, especially depth of the safety design such as backup reactor shutdown system, decay heat removal function in a natural circulation mode etc. (J.P.N.)

  6. A novel topical association with zinc oxide, chamomile and aloe vera extracts - stability and safety studies

    Directory of Open Access Journals (Sweden)

    Catarina Reis

    2015-12-01

    Full Text Available Currently, natural products show an enormous potential for pharmaceutical and cosmetic industries. The goals of this study were to formulate and to characterise a novel combination of natural products. Formulations were 1 an oil-in-water emulsion, 2 a water-in-oil emulsion and 3 a cleansing solution. Zinc oxide was chosen as an active ingredient due to its healing properties, and chamomile and aloe vera extracts were chosen due to their antiseptic, anti-inflammatory and tissue regenerating properties. Organoleptic characteristics, pH, viscosity and in vitro efficacy for the most common bacteria and yeast of human skin were evaluated. Preliminary and accelerated stability studies and safety tests were also performed. All optimized products were stable, smooth in texture, effective against bacteria and yeast, and safe, justifying further studies. Results suggest that these novel products might be a promising source of natural compounds with soothing and regenerative properties for skin care.

  7. A Preliminary Feasibility Study On Seismic Monitoring Of Polymer Flooding

    Science.gov (United States)

    Nguyen, P. K.; Park, C.; Lim, B.; Nam, M.

    2012-12-01

    Polymer flooding using water with soluble polymers is an enhanced oil recovery technique, which intends to maximize oil-recovery sweep efficiency by minimizing fingering effects and as a result creating a smooth flood front; polymer flooding decreases the flow rates within high permeability zone while enhances those of lower permeabilities. Understanding of fluid fronts and saturations is critical to not only optimizing polymer flooding but also monitoring the efficiency. Polymer flooding monitoring can be made in single well scale with high-resolution wireline logging, in inter-well scale with tomography, and in reservoir scale with surface survey. For reservoir scale monitoring, this study makes a preliminary feasibility study based on constructing rock physics models (RPMs), which can bridge variations in reservoir parameters to the changes in seismic responses. For constructing RPMs, we change reservoir parameters with consideration of polymer flooding to a reservoir. Time-lapse seismic data for corresponding RPMs are simulated using a time-domain staggered-finite-difference modeling with implementation of a boundary condition of conventional perfect match layer. Analysis on time-lapse seismic data with respect to the changes in fluid front and saturation can give an insight on feasibility of surface seismic survey to polymer flooding. Acknowledgements: This work was supported by the Energy Efficiency & Resources of the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea government Ministry of Knowledge Economy (No. 2012T100201588). Myung Jin Nam was partially supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MEST) (No. 2011-0014684).

  8. Nevada potential repository preliminary transportation strategy: Study 1

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1995-04-01

    Limited feasible options exist when considering the shipment of spent nuclear fuel and high-level radioactive waste. These options are rail or truck; because of the weight associated with transportation casks (68.0 to 113.4 tonnes/75 to 125 tons), heavy-haul trucks are also considered. Yucca Mountain currently lacks rail service or an existing right-of-way for rail; it also lacks a dedicated highway suitable for heavy-haul trucks. Approximately 11,230 shipments by rail are planned from waste producer sites to Nevada, with an additional 1,041 shipments by legal-weight truck from four reactor sites not capable of upgrading for rail shipment. This study identifies the reasonable alternatives for waste transport to the potential repository site, describes the evaluation process performed to identify those alternatives, and discusses the reasons for elimination of transportation routes deemed to be not reasonable. The study concluded that heavy haul truck transportation is feasible-cost is very favorable when compared to rail-but route restrictions must be further evaluated. In addition to restrictions due to seasonal weather conditions, specific routes have additional restrictions, including no travel on holidays or weekends, and travel during daylight hours only. Further restrictions will be imposed by the U.S. Department of Transportation based on routing of radioactive materials by highway. Operation and maintenance costs for heavy-haul over a 24-year period, based on preliminary information, were calculated on an estimated operational cost of $15,000 per trip, with an estimated 468 trips per year average (11,230 total trips), for an estimated cost of $171 million to $173 million, depending on the route used. Because the initial costs and the total system life cycle costs of heavy-haul are approximately 50 percent lower than the lowest rail cost, this option will continue to be evaluated.

  9. [Study of post marketing safety reevaluation of shenqi fuzheng injection].

    Science.gov (United States)

    Ai, Qing-Hua; Li, Yuan-Yuan; Xie, Yan-Ming

    2014-09-01

    In order to promote the Shenqifuzheng injection (SQFZ) clinical medication safety, this study reevaluate on SQFZ post marketing safety study systematically. Including multi center large sample registration type safety monitoring research, the analysis based on national spontaneous reporting system data, the analysis based on the 20 national hospital information system data and literature research. Above the analysis, it suggests that SQFZ has good security. The more adverse drug reaction (ADR) as allergic reactions, mainly involved in the damage of skin, appendages and its systemic damage, serious person can appear allergic shock. ADR/E is more common in the elderly, may be related to medication (tumor) populations. Early warning analysis based on SRS data and literature research are of the view that "phlebitis" has a strong association with SQFZ used.

  10. A Preliminary Study on Cathodic Prevention in Reinforced Mortar

    NARCIS (Netherlands)

    Koleva, D.A.; Van Breugel, K.; Mol, J.M.C.; De Wit, J.H.W.

    2010-01-01

    This work presents the preliminary tests on the performance of cathodic prevention (CPre) in reinforced mortar, subjected to aggressive (10% NaCl environment). Cathodic prevention is an electrochemical technique for minimizing, actually "preventing" any eventual corrosion of the steel bars in reinfo

  11. Technology User Groups and Early Childhood Education: A Preliminary Study

    Science.gov (United States)

    Parette, Howard P.; Hourcade, Jack J.; Blum, Craig; Watts, Emily H.; Stoner, Julia B.; Wojcik, Brian W.; Chrismore, Shannon B.

    2013-01-01

    This article presents a preliminary examination of the potential of Technology User Groups as a professional development venue for early childhood education professionals in developing operational and functional competence in using hardware and software components of a Technology toolkit. Technology user groups are composed of varying numbers of…

  12. Orofacial Muscle Activity of Children Who Stutter: A Preliminary Study.

    Science.gov (United States)

    Kelly, Ellen M.; And Others

    1995-01-01

    This preliminary investigation of stuttering development and maturation of speech motor processes recorded the electromyographic activity of the orofacial muscles of nine children who stuttered. Results suggest that the emergence of tremor-like instabilities in the speech motor processes of stuttering children may coincide with aspects of general…

  13. Orofacial Muscle Activity of Children Who Stutter: A Preliminary Study.

    Science.gov (United States)

    Kelly, Ellen M.; And Others

    1995-01-01

    This preliminary investigation of stuttering development and maturation of speech motor processes recorded the electromyographic activity of the orofacial muscles of nine children who stuttered. Results suggest that the emergence of tremor-like instabilities in the speech motor processes of stuttering children may coincide with aspects of general…

  14. Finite element modelling of the tricuspid valve: A preliminary study.

    Science.gov (United States)

    Stevanella, Marco; Votta, Emiliano; Lemma, Massimo; Antona, Carlo; Redaelli, Alberto

    2010-12-01

    The incomplete efficacy of current surgical repair procedures of the tricuspid valve (TV) demands a deeper comprehension of the physiological TV biomechanics. To this purpose, computational models can provide quantitative insight into TV biomechanical response and allow analysing the role of each TV substructure. We present here a three-dimensional finite element model of the tricuspid valve that takes into account most of its peculiar features. Experimental measurements were performed on human and porcine valves to obtain a more detailed TV anatomical framework. To overcome the complete lack of information on leaflets mechanical properties, we performed a sensitivity analysis on the parameters of the adopted non-linear hyperelastic constitutive model, hypothesizing three different parameter sets for three significant collagen fibre distributions. Results showed that leaflets' motion and maximum principal stress distribution were almost insensitive to the different material parameters considered. Highest stresses (about 100kPa) were located near the annulus of the anterior and septal leaflets, while the posterior leaflet experienced lower stresses (about 55kPa); stresses at the commissures were nearly zero. Conversely, changes in constitutive parameters deeply affected leaflets' strains magnitude, but not their overall pattern. Strains computed assuming that TV leaflets tissue are reinforced by a sparse and loosely arranged network of collagen fibres fitted best experimental data, thus suggesting that this may be the actual microstructure of TV leaflets. In a long-term perspective, this preliminary study aims at providing a starting point for the development of a predictive tool to quantitatively evaluate TV diseases and surgical repair procedures.

  15. Adsorption of Roxarsone onto Drinking Water Treatment Residuals: Preliminary Studies

    Science.gov (United States)

    Salazar, J.; Sarkar, D.; Datta, R.; Sharma, S.

    2006-05-01

    above parameters were varied one at a time to study their effects on roxarsone adsorption. Desorption studies were carried out using 125 mg/L phosphorous at predetermined interval of time. In addition to analyzing for total As by an ICP-MS, aqueous speciation of As was performed using a coupled HPLC-ICP-MS system. Preliminary studies show significant roxarsone adsorption capacity of the WTRs.

  16. Preliminary study for small animal preclinical hadrontherapy facility

    Science.gov (United States)

    Russo, G.; Pisciotta, P.; Cirrone, G. A. P.; Romano, F.; Cammarata, F.; Marchese, V.; Forte, G. I.; Lamia, D.; Minafra, L.; Bravatá, V.; Acquaviva, R.; Gilardi, M. C.; Cuttone, G.

    2017-02-01

    Aim of this work is the study of the preliminary steps to perform a particle treatment of cancer cells inoculated in small animals and to realize a preclinical hadrontherapy facility. A well-defined dosimetric protocol was developed to explicate the steps needed in order to perform a precise proton irradiation in small animals and achieve a highly conformal dose into the target. A precise homemade positioning and holding system for small animals was designed and developed at INFN-LNS in Catania (Italy), where an accurate Monte Carlo simulation was developed, using Geant4 code to simulate the treatment in order to choose the best animal position and perform accurately all the necessary dosimetric evaluations. The Geant4 application can also be used to realize dosimetric studies and its peculiarity consists in the possibility to introduce the real target composition in the simulation using the DICOM micro-CT image. This application was fully validated comparing the results with the experimental measurements. The latter ones were performed at the CATANA (Centro di AdroTerapia e Applicazioni Nucleari Avanzate) facility at INFN-LNS by irradiating both PMMA and water solid phantom. Dosimetric measurements were performed using previously calibrated EBT3 Gafchromic films as a detector and the results were compared with the Geant4 simulation ones. In particular, two different types of dosimetric studies were performed: the first one involved irradiation of a phantom made up of water solid slabs where a layer of EBT3 was alternated with two different slabs in a sandwich configuration, in order to validate the dosimetric distribution. The second one involved irradiation of a PMMA phantom made up of a half hemisphere and some PMMA slabs in order to simulate a subcutaneous tumour configuration, normally used in preclinical studies. In order to evaluate the accordance between experimental and simulation results, two different statistical tests were made: Kolmogorov test and

  17. Safety of amisulpride (Solian): a review of 11 clinical studies.

    Science.gov (United States)

    Coulouvrat, C; Dondey-Nouvel, L

    1999-07-01

    We assessed the overall safety profile of amisulpride based on the results from 11 clinical studies performed in patients suffering from schizophrenia with predominance of positive or negative symptoms. A total of 1933 patients were randomly assigned to treatment with amisulpride (n = 1247) or haloperidol (n = 309), risperidone (n = 113), flupentixol (n = 62) and placebo (n = 202). Safety data collection was performed using open reporting, UKU scales or specific extrapyramidal side-effect scales; electrocardiogram recording and vital signs examination; laboratory data collection. Amisulpride demonstrated a satisfactory global safety profile in the range of doses usually prescribed. The number of patients having at least one extrapyramidal side-effect was higher in haloperidol patients compared with both amisulpride and risperidone patients (50% versus 30% in the two latter groups). For endocrine events, a similar rate was observed between amisulpride and risperidone groups (4% versus 6%, respectively) versus 1% in the haloperidol group. Electrocardiogram results were satisfactory, confirmed by the absence of cardiovascular events. The overall laboratory safety profile of amisulpride did not show clinically relevant abnormalities in liver function tests nor haematological abnormalities. Our extensive clinical data confirm the satisfactory safety profile of amisulpride which is superior to standard reference compounds.

  18. Grasslands contaminant study selenium in algae and wintering and resident waterfowl and waterbirds : preliminary summary

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — A preliminary summary of a study of contaminants in waterbirds and in the western grasslands of Merced County. The purpose of this study was two-fold: 1) to...

  19. The effects of workload on respiratory variables in simulated flight: a preliminary study.

    Science.gov (United States)

    Karavidas, Maria Katsamanis; Lehrer, Paul M; Lu, Shou-En; Vaschillo, Evgeny; Vaschillo, Bronya; Cheng, Andrew

    2010-04-01

    In this pilot study, we investigated respiratory activity and end-tidal carbon dioxide (P(et)CO(2)) during exposure to varying levels of work load in a simulated flight environment. Seven pilots (age: 34-60) participated in a one-session test on the Boeing 737-800 simulator. Physiological data were collected while pilots wore an ambulatory multi-channel recording device. Respiratory variables, including inductance plethysmography (respiratory pattern) and pressure of end-tidal carbon dioxide (P(et)CO(2)), were collected demonstrating change in CO(2) levels proportional to changes in flight task workload. Pilots performed a set of simulation flight tasks. Pilot performance was rated for each task by a test pilot; and self-report of workload was taken using the NASA-TLX scale. Mixed model analysis revealed that respiration rate and minute ventilation are significantly associated with workload levels and evaluator scores controlling for "vanilla baseline" condition. Hypocapnia exclusively occurred in tasks where pilots performed more poorly. This study was designed as a preliminary investigation in order to develop a psychophysiological assessment methodology, rather than to offer conclusive findings. The results show that the respiratory system is very reactive to high workload conditions in aviation and suggest that hypocapnia may pose a flight safety risk under some circumstances. Copyright © 2010 Elsevier B.V. All rights reserved.

  20. Experimental method and preliminary studies of the passive containment water film evaporation mass transfer

    Energy Technology Data Exchange (ETDEWEB)

    Li, Cheng [State Nuclear Power Technology Research, Beijing (China). Development Center; State Nuclear Power Research Institute, Beijing (China); Yang, Lin; Zhao, Wei; Zhou, Shan; Du, Wangfang; Gao, Zhan; Li, Honegsen [State Nuclear Power Technology Research, Beijing (China). Development Center

    2017-05-15

    For larger containments and higher operation parameters, characteristics of the outside cooling of the PCCS are very important for the analysis on the containment integrity. A preliminary analysis was made and a four-step experimental method was used to numerically analyze the falling water film evaporation for the advanced passive containment. Then, the water flow stability along the outside wall of the containment was studied. The results fit well with those correlations without airflow when the air velocity is less than 5.0 m/s. However, when the air velocity is larger than 5.0 m/s, the influence of the air velocity on the water film will appear and the mean water film thickness will be thicker. Based on the prototype operation parameters, experimental studies were carried and the results were compared with the Dittus-Boelter correlation within the operation ranges. A modification factor was proposed for the conservative application of this correlation for nuclear safety analysis.

  1. Development of safety analysis technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Suk K.; Song, J. H.; Chung, Y. J. and others

    1999-03-01

    Inherent safety features and safety system characteristics of the SMART integral reactor are investigated in this study. Performance and safety of the SMART conceptual design have been evaluated and confirmed through the performance and safety analyses using safety analysis system codes as well as a preliminary performance and safety analysis methodology. SMART design base events and their acceptance criteria are identified to develop a preliminary PIRT for the SMART integral reactor. Using the preliminary PIRT, a set of experimental program for the thermal hydraulic separate effect tests and the integral effect tests was developed for the thermal hydraulic model development and the system code validation. Safety characteristics as well as the safety issues of the integral reactor has been identified during the study, which will be used to resolve the safety issues and guide the regulatory criteria for the integral reactor. The results of the performance and safety analyses performed during the study were used to feedback for the SMART conceptual design. The performance and safety analysis code systems as well as the preliminary safety analysis methodology developed in this study will be validated as the SMART design evolves. The performance and safety analysis technology developed during the study will be utilized for the SMART basic design development. (author)

  2. The uses of exposure and risk in road safety studies.

    NARCIS (Netherlands)

    Hakkert, A.S. & Braimaister, L.

    2002-01-01

    This report explores the theoretical possibilities of defining exposure and risk, discusses the problems associated with the use of exposure and risk, and gives examples of various safety studies in which use is made of exposure and risk indicators. The report sets out with a definition of the three

  3. [Peritoneal equilibration test: Conventional versus adapted. Preliminary study].

    Science.gov (United States)

    Zaloszyc, Ariane; Schmitt, Claus Peter; Schaefer, Betti; Doutey, Armelle; Terzic, Joëlle; Menouer, Soraya; Higel, Laetitia; Fischbach, Michel

    2017-02-01

    Conventional automated peritoneal dialysis (APD) is prescribed as a repetition of cycles with the same dwell time and the same fill volume. Water and sodium balance remains a common problem among patients on peritoneal dialysis. More recently, adapted automated peritoneal dialysis was described, as a combination of short dwells with a low volume, in order to enhance ultrafiltration, followed by long dwells with a large fill volume to favor solute removal. We performed a preliminary crossover study on 4 patients. The total amount of dialysate was the same, i.e. 2L/m(2) as well as the total duration of the test, i.e. 150 minutes. The conventional test was made with two identical cycles, each cycle had a fill volume of 1L/m(2) and a duration of 75 minutes, while the adapted test was performed with one short cycle, i.e. 30 minutes with a low fill volume, i.e. 0.6L/m(2), followed by a long cycle, i.e. 120 minutes, with a large fill volume, i.e. 1.4L/m(2). Sodium extraction was improved by 29.3mmol/m(2) (169%) in the adapted test in comparison to the conventional test. Ultrafiltration was enhanced by 159mL/m(2) (128%) in the adapted test compared to the conventional one. Glucose absorption was decreased by 35% in the adapted test in comparison to the conventional test and osmotic conductance was also improved. In conclusion, adapted dialysis may allow for a better volume and sodium balance, since we observed an improvement in sodium extraction and ultrafiltration. This pre-study authorizes an improvement of the European Pediatric Study's protocol on Adapted APD, already started and which will continue in the next months. Copyright © 2016 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.

  4. Preliminary study: Formaldehyde exposure in laboratories of Sharjah university in UAE

    Directory of Open Access Journals (Sweden)

    Hafiz Omer Ahmed

    2011-01-01

    Full Text Available Objectives : Laboratory technicians, students, and instructors are at high risk, because they deal with chemicals including formaldehyde. Thus, this preliminary study was conducted to measure the concentration of formaldehyde in the laboratories of the University of Sharjah in UAE. Materials and Methods: Thirty-two air samples were collected and analyzed for formaldehyde using National Institute for Occupational Safety and Health (NIOSH method 3500. In this method, formaldehyde reacts with chromotropic acid in the presence of sulfuric acid to form a colored solution. The absorbance of the colored solution is read in spectrophotometer at wavelength 580 nm and is proportional to the quantity of the formaldehyde in the solution. Results: For the anatomy laboratory and in the presence of the covered cadaver, the mean concentration of formaldehyde was found to be 0.100 ppm with a range of 0.095-0.105 ppm. Whereas for the other laboratories, the highest mean concentration of formaldehyde was 0.024 ppm in the general microbiology laboratory and the lowest mean concentration of formaldehyde was 0.001 ppm in the environmental health laboratory. The 8-hour (time-weighted average concentration of formaldehyde was found to be ranging between 0.0003 ppm in environmental health laboratory and 0.026 ppm in the anatomy laboratory. Conclusions: The highest level of concentration of formaldehyde in the presence of the covered cadaver in anatomy laboratory exceeded the recommended ceiling standard established by USA-NIOSH which is 0.1 ppm, but below the ceiling standard established by American Conference of Governmental Industrial Hygienists which is 0.3 ppm. Thus, it is recommended that formaldehyde levels should be measured periodically specially during the dissection in the anatomy laboratory, and local exhaust ventilation system should be installed and personal protective equipment such as safety glass and gloves should be available and be used to prevent

  5. Use of cross-linked carboxymethyl cellulose for soft-tissue augmentation: preliminary clinical studies

    Directory of Open Access Journals (Sweden)

    Mauro Leonardis

    2010-11-01

    Full Text Available Mauro Leonardis1, Andrea Palange2, Rodrigo FV Dornelles3, Felipe Hund41Department of Plastic Surgery, Salvator Mundi International Hospital, Roma, Italy; 2Department of Aesthetic Medicine, Fisiobios, Roma, Italy; 3Department of Plastic Surgery, Núcleo de Plástica Avançada, São Paulo, SP, Brazil; 4Department of Plastic Surgery, Consultorio de Cirurgia Plastica, Criciuma, SC, BrazilPurpose: The continual search for new products for soft-tissue augmentation has in recent years led to the introduction of long lasting alternatives to hyaluronic acids and collagen that are composed of other polymers able to improve clinical persistence over time. This is the first report in which sodium carboxymethyl cellulose (CMC has been chemically treated by the cross-linking process and thus used as a hydrogel for soft-tissue augmentation through injection with thin needles. The study evaluates, from a clinical point of view, the behavior of cross-linked carboxymethyl cellulose hydrogel used in the aesthetic field and its side effects so as to check the safety and performance of the polymer following intradermal injections.Patients and methods: This work shows the preliminary results of an ongoing clinical study conducted between 2006 and 2009, performed on 84 healthy volunteers (62 females, 22 males aged between 18 and 72 years, for the treatment of 168 nasolabial folds, 45 perioral wrinkles, and 39 lip volume.Results: Study results show an excellent correction of facial defects. Tolerance and aesthetic quality of the correction obtained indicate considerable safety features and absence of side effects. From a clinical point of view, hydrogel is gradually absorbed into the injection site without migration issues.Conclusion: Cross-linked CMC hydrogel proves to be an ideal agent for soft tissue augmentation with regard to safety and ease of application. It did not cause infection, extrusion, migration, or adverse reactions in the patients who have been

  6. A study on drug safety monitoring program in India

    Directory of Open Access Journals (Sweden)

    A Ahmad

    2014-01-01

    Full Text Available Pharmacovigilance is useful in assuring the safety of medicines and protecting the consumers from their harmful effects. A number of single drugs as well as fixed dose combinations have been banned from manufacturing, marketing and distribution in India. An important issue about the availability of banned drugs over the counter in India is that sufficient adverse drug reactions data about these drugs have not been reported. The most common categories of drugs withdrawn in the last decade were nonsteroidal antiinflammatory drugs (28%, antidiabetics (14.28%, antiobesity (14.28%, antihistamines (14.28%, gastroprokinetic drugs (7.14%, breast cancer and infertility drugs (7.14%, irritable bowel syndrome and constipation drugs (7.14% and antibiotics (7.14%. Drug withdrawals from market were made mainly due to safety issues involving cardiovascular events (57.14% and liver damage (14.28%. Majority of drugs have been banned since 3-5 years in other countries but are still available for sale in India. The present study compares the drug safety monitoring systems in the developed countries such as the USA and UK and provides implications for developing a system that can ensure the safety and efficacy of drugs in India. Absence of a gold standard for a drug safety surveillance system, variations in culture and clinical practice across countries makes it difficult for India to completely adopt another country′s practices. There should be a multidisciplinary approach towards drug safety that should be implemented throughout the entire duration spanning from drug discovery to usage by consumers.

  7. Preliminary experimental study of a carbon fiber array cathode

    Science.gov (United States)

    Li, An-kun; Fan, Yu-wei

    2016-08-01

    The preliminary experimental results of a carbon fiber array cathode for the magnetically insulated transmission line oscillator (MILO) operations are reported. When the diode voltage and diode current were 480 kV and 44 kA, respectively, high-power microwaves with a peak power of about 3 GW and a pulse duration of about 60 ns were obtained in a MILO device with the carbon fiber array cathode. The preliminary experimental results show that the shot-to-shot reproducibility of the diode current and the microwave power is stable until 700 shots. No obvious damage or deterioration can be observed in the carbon fiber surface morphology after 700 shots. Moreover, the cathode performance has no observable deterioration after 700 shots. In conclusion, the maintain-free lifetime of the carbon fiber array cathode is more than 700 shots. In this way, this carbon fiber array cathode offers a potential replacement for the existing velvet cathode.

  8. Preliminary Studies on Pulsed Electric Field Breakdown of Lead Azide

    Science.gov (United States)

    1976-10-01

    1/2 OS CO ton NO. S3L TECHNICAL REPORT 4991 PRELIMINARY SUJDfES ON PULSED ELECTRIC FIELD BREAKDOWN OF LEAD AZIDE L AVRAMI M. BUMS D. DOWNS...Introduction Background A. Contact Effects B. Pulsed Electric Field Measurements Experimental A. Contact Effects B. Pulsed Electric Fields Discussion...B. Pulsed Electric Field Measurements The application of pulsed electric fields to lead azide does not exactly simulate the conditions experienced

  9. PRELIMINARY STUDY OF FISH CULTURE IN ABANDONED SAND MINING POOL

    Directory of Open Access Journals (Sweden)

    Bambang Gunadi

    2006-12-01

    Full Text Available One of main problems in freshwater aquaculture development in Indonesia, especially in Java, is unavailability of developing zone. It is important to find an underutilized area that meets for industrial scale freshwater aquaculture, i.e. sufficient water supply, wide area, and located in one area or zone. The abandoned mining (sand, tin, etc. pools distributed along the country might be the potential area for freshwater aquaculture business. For example, there are at least 13 water pools with total surface area of 250 ha at 15 km side of Citarum River in Karawang District (West Java Province. This study was conducted to obtain preliminary data about the prospect and potency of fish culture (tilapia, clariid catfish, and ‘patin’ catfish in abandoned sand-mining pools in Karawang District. Mini floating net cages of 1 x 1 x 1.5 m3 size were used for culturing fish, i.e. patin catfish (Pangasianodon hypophthalmus, nile tilapia (Oreochromis niloticus, and clariid catfish (Clarias gariepinus, separately. Patin catfish were stocked at a size of 2 g with a density of 300 fish per cage, tilapia were stocked at a size of 6 g with a density of 400 fish per cage, while  the clariid catfish were stocked at a size of 1.4 g with a density of 980 fish per cage. A floating commercial feed (30%—32% protein, 3%—5% fat was used at a daily rate of 9% biomass weight at the beginning and reduced gradually to 3% at the final culture period. Observed data showed that patin catfish grew from the initial size of 2.08 g to the final size 299.59 g in 5 months, nile tilapia grew from individual initial size of 5.92 g to the final size of 247.12 g in 14 weeks, and clariid catfish grew from initial size of 1.39 g to the final size of 73.10 g in 8 weeks. These three species were technically prospective for aquaculture development in the abandoned sand-mining pools.

  10. Preliminary design studies of underground pumped hydro and compressed-air energy storage in hard rock. Volume 10: Environmental studies

    Science.gov (United States)

    1981-04-01

    Results of preliminary environmental assessments for a proposed UPH or CAES demonstration facility are presented. Included are characterizations of the existing environment of the sunshine site in Montgomery County, Maryland, and assessments of environmental impacts and public safety concerns. Elements of the existing environment which are considered sensitive are described. Environmental impacts are identified, rated, and described for both alternative demonstration facilities. Public safety concerns for both alternative demonstration facilities are also identified and discussed. These include, for both UPH and CAES, underground cavern collapse and surface subsidence, explosives, site security, icing, upper reservoir failure, and mechanical failure of plant equipment. In addition, fuel handling and the champagne effect are addressed for CAES.

  11. Preliminary assessment of cardiac short term safety and efficacy of manganese chloride for cardiovascular magnetic resonance in humans

    Directory of Open Access Journals (Sweden)

    Kalaf Jose M

    2011-01-01

    Full Text Available Abstract Background Manganese based agents are intracellular and accumulate inside myocytes allowing for different imaging strategies compared to gadolinium contrasts. While previous agents release manganese very slowly in the circulation, MnCl2 allows for rapid Mn2+ uptake in myocytes, creating a memory effect that can be potentially explored. Data on animal models are very encouraging but the safety and efficacy of this approach in humans has not yet been investigated. Therefore, our objectives were to study the safety and efficacy of a rapid infusion of manganese chloride (MnCl2 for cardiovascular magnetic resonance (CMR in humans. Methods Fifteen healthy volunteers underwent a CMR scan on a 1.5 T scanner. Before the infusion, cardiac function was calculated and images of a short axis mid-ventricular slice were obtained using a 2D and 3D gradient-echo inversion recovery (GRE-IR sequence, a phase-sensitive IR sequence and a single breath-hold segmented IR prepared steady-state precession acquisition for T1 calculations. MnCl2 was infused over three minutes at a total dose of 5 μMol/kg. Immediately after the infusion, and at 15 and 30 minutes later, new images were obtained and cardiac function re-evaluated. Results There was a significant decrease in T1 values compared to baseline, sustained up to 30 minutes after the MnCl2 infusion (pre,839 ± 281 ms; 0 min, 684 ± 99; 15 min, 714 ± 168; 30 min, 706 ± 172, P = 0.003. The 2D and 3D GRE-IR sequence showed the greatest increase in signal-to-noise ratio compared to the other sequences (baseline 6.6 ± 4.2 and 9.7 ± 5.3; 0 min, 11.3 ± 4.1 and 15.0 ± 8.7; 15 min, 10.8 ± 4.0 and 16.9 ± 10.2; 30 min, 10.6 ± 5.2 and 16.5 ± 8.3, P 2 with no major adverse events, despite all reporting transient facial flush. Conclusions In the short term, MnCl2 appears safe for human use. It effectively decreases myocardium T1, maintaining this effect for a relatively long period of time and allowing for the

  12. Safety and preliminary immunogenicity of Cuban pneumococcal conjugate vaccine candidate in healthy children: a randomized phase I clinical trial.

    Science.gov (United States)

    Dotres, Carlos P; Puga, Rinaldo; Ricardo, Yariset; Broño, Carmen R; Paredes, Beatriz; Echemendía, Vladimir; Rosell, Sandra; González, Nadezhda; García-Rivera, Dagmar; Valdés, Yury; Goldblatt, David; Vérez-Bencomo, Vicente

    2014-09-15

    A new heptavalent conjugate vaccine (PCV7-TT) is under development in Cuba. PCV7-TT contains 2 μg of serotypes 1, 5, 14, 18C, 19F, 23F and 4 μg of 6B, each one conjugated to tetanus toxoid (TT). This vaccine was designed with the serotypes that cause most invasive pneumococcal diseases (IPD) worldwide. In the present study, we investigated the safety and explored the immunogenicity of PCV7-TT during a controlled, randomized and double blind clinical trial phase I in 4-5-year-old children. PCV7-TT was well tolerated and as safe as Synflorix used as control vaccine. Following a single-dose vaccination, all individual serotypes included in PCV7-TT induced statistically significant increase of IgG GMC and OPA GMT. These are the first clinical results of PCV7-TT in children and they pave the way toward next clinical trials in children and infants. This clinical trial was published in the Cuban Public Register of Clinical Trials with code RPCEC00000173.

  13. 77 FR 27776 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-05-11

    ... (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2... and funding cycles pertaining to research issues in occupational safety and health, and allied areas... focused research projects, which will lead to improvements in the delivery of occupational safety...

  14. 77 FR 75633 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-12-21

    ... (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2... research issues in occupational safety and health, and allied areas. It is the intent of NIOSH to support... improvements in the delivery of occupational safety and health services, and the prevention of...

  15. 77 FR 51810 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2012-08-27

    ... (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2... and funding cycles pertaining to research issues in occupational safety and health, and allied areas... focused research projects, which will lead to improvements in the delivery of occupational safety...

  16. 75 FR 5333 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2010-02-02

    ... (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2... cycles pertaining to research issues in occupational safety and health, and allied areas. It is the... projects, which will lead to improvements in the delivery of occupational safety and health services,...

  17. 76 FR 18220 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2011-04-01

    ... (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2... and funding cycles pertaining to research issues in occupational safety and health, and allied areas... focused research projects, which will lead to improvements in the delivery of occupational safety...

  18. Pilot Study on Harmonisation of Reactor Safety in WENRA Countries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    Most of the objectives, set for the Pilot Study, were met. It can be concluded that the methodology was adequate for its purpose. National requirements on selected safety issues have been systematically compared and the major gaps and differences have been identified. Convenient overviews have been provided of differences and similarities between the countries. Furthermore, the conclusions are based on a safety justification and are detailed enough to provide input to a further more detailed analysis on the national level. It was not possible, however, to provide fully verified conclusions about the implementation of the reference levels in the different countries. This has to do with the following constraints on the study: In line with the Terms of Reference, the comparison of formal requirements did not address the more detailed use of criteria and methods to verify compliance. The same requirement could be enforced differently in different regulatory systems, and hence lead to different implementation. The Pilot Study also assessed the implementation, but it was not possible to do this in sufficient detail to identify such differences. The implementation was assessed on the basis of current knowledge of the respective regulatory body, but it was not possible to provide the panels with evidence of the implementation. For these reasons, conclusions about implemented safety provisions in the different countries should be drawn with precaution. The introduction of the panel assessments greatly improved the quality and consistency of the comparison assessments. Uncertainties in the assessments are mainly connected with lack of time to make a detailed analysis in some cases. The reliability of the assessments seems to be sufficient for the objectives of the Pilot Study. The introduction of the IAEA safety standards in the study proved to be helpful and provided confidence in the scope and strictness of the reference levels. This Pilot Study has contributed to

  19. Safety Risk Knowledge Elicitation in Support of Aeronautical R and D Portfolio Management: A Case Study

    Science.gov (United States)

    Shih, Ann T.; Ancel, Ersin; Jones, Sharon Monica; Reveley, Mary S.; Luxhoj, James T.

    2012-01-01

    Aviation is a problem domain characterized by a high level of system complexity and uncertainty. Safety risk analysis in such a domain is especially challenging given the multitude of operations and diverse stakeholders. The Federal Aviation Administration (FAA) projects that by 2025 air traffic will increase by more than 50 percent with 1.1 billion passengers a year and more than 85,000 flights every 24 hours contributing to further delays and congestion in the sky (Circelli, 2011). This increased system complexity necessitates the application of structured safety risk analysis methods to understand and eliminate where possible, reduce, and/or mitigate risk factors. The use of expert judgments for probabilistic safety analysis in such a complex domain is necessary especially when evaluating the projected impact of future technologies, capabilities, and procedures for which current operational data may be scarce. Management of an R&D product portfolio in such a dynamic domain needs a systematic process to elicit these expert judgments, process modeling results, perform sensitivity analyses, and efficiently communicate the modeling results to decision makers. In this paper a case study focusing on the application of an R&D portfolio of aeronautical products intended to mitigate aircraft Loss of Control (LOC) accidents is presented. In particular, the knowledge elicitation process with three subject matter experts who contributed to the safety risk model is emphasized. The application and refinement of a verbal-numerical scale for conditional probability elicitation in a Bayesian Belief Network (BBN) is discussed. The preliminary findings from this initial step of a three-part elicitation are important to project management practitioners as they illustrate the vital contribution of systematic knowledge elicitation in complex domains.

  20. Safety Risk Knowledge Elicitation in Support of Aeronautical R and D Portfolio Management: A Case Study

    Science.gov (United States)

    Shih, Ann T.; Ancel, Ersin; Jones, Sharon Monica; Reveley, Mary S.; Luxhoj, James T.

    2012-01-01

    Aviation is a problem domain characterized by a high level of system complexity and uncertainty. Safety risk analysis in such a domain is especially challenging given the multitude of operations and diverse stakeholders. The Federal Aviation Administration (FAA) projects that by 2025 air traffic will increase by more than 50 percent with 1.1 billion passengers a year and more than 85,000 flights every 24 hours contributing to further delays and congestion in the sky (Circelli, 2011). This increased system complexity necessitates the application of structured safety risk analysis methods to understand and eliminate where possible, reduce, and/or mitigate risk factors. The use of expert judgments for probabilistic safety analysis in such a complex domain is necessary especially when evaluating the projected impact of future technologies, capabilities, and procedures for which current operational data may be scarce. Management of an R&D product portfolio in such a dynamic domain needs a systematic process to elicit these expert judgments, process modeling results, perform sensitivity analyses, and efficiently communicate the modeling results to decision makers. In this paper a case study focusing on the application of an R&D portfolio of aeronautical products intended to mitigate aircraft Loss of Control (LOC) accidents is presented. In particular, the knowledge elicitation process with three subject matter experts who contributed to the safety risk model is emphasized. The application and refinement of a verbal-numerical scale for conditional probability elicitation in a Bayesian Belief Network (BBN) is discussed. The preliminary findings from this initial step of a three-part elicitation are important to project management practitioners as they illustrate the vital contribution of systematic knowledge elicitation in complex domains.

  1. Summary of the Preliminary Optical ICHMI Design Study: A Preliminary Engineering Design Study for a Standpipe Viewport

    Energy Technology Data Exchange (ETDEWEB)

    Anheier, Norman C.; Qiao, Hong (Amy); Berglin, Eric J.; Hatchell, Brian K.

    2013-12-26

    This summary report examines an in-vessel optical access concept intended to support standoff optical instrumentation, control and human-machine interface (ICHMI) systems for future advanced small modular reactor (AdvSMR) applications. Optical-based measurement and sensing systems for AdvSMR applications have several key benefits over traditional instrumentation and control systems used to monitor reactor process parameters, such as temperature, flow rate, pressure, and coolant chemistry (Anheier et al. 2013). Direct and continuous visualization of the in-vessel components can be maintained using external cameras. Many optical sensing techniques can be performed remotely using open optical beam path configurations. Not only are in-vessel cables eliminated by these configurations, but also sensitive optical monitoring components (e.g., electronics, lasers, detectors, and cameras) can be placed outside the reactor vessel in the instrument vault, containment building, or other locations where temperatures and radiation levels are much lower. However, the extreme AdvSMR environment present challenges for optical access designs and optical materials. Optical access is not provided in any commercial nuclear power plant or featured in any reactor design, although successful implementation of optical access has been demonstrated in test reactors (Arkani and Gharib 2009). This report outlines the key engineering considerations for an AdvSMR optical access concept. Strict American Society of Mechanical Engineers (ASME) construction codes must be followed for any U.S. nuclear facility component (ASME 2013); however, the scope of this study is to evaluate the preliminary engineering issues for this concept, rather than developing a nuclear-qualified design. In addition, this study does not consider accident design requirements. In-vessel optical access using a standpipe viewport concept serves as a test case to explore the engineering challenges and performance requirements

  2. Cerebellar stimulation for spastic cerebral palsy: preliminary report; on-going double blind study.

    Science.gov (United States)

    Schulman, J H; Davis, R; Nanes, M

    1987-01-01

    To date, June 1, 1986, 33 spastic cerebral palsy (CP) patients have taken part in a double blind study testing the safety and efficacy of chronic cerebellar stimulation (CCS) for reduction of spasticity and improvement in function. Seven U.S. surgical centers involving ten neurosurgeons have implanted the Neurolith 601 cerebellar stimulator supplied by Pacesetter Systems Inc. (Sylmar, CA). A pilot study was run with three patients at Stanford University (Stanford, CA) using taped-on real (strong) and dummy (weak) magnets to control the ON-OFF status. Following the pilot study, a magnetically controllable switch was placed in line between the Neurolith stimulator and the cerebellar lead to allow more reliable switching sequences for the study. The test battery included joint angle measurements (passive and active), motor performance testing, reaction time, hand dynamometry, grooved peg board placement, hand/foot tapping, and rotary pursuit testing. Testing only was done at presurgery. Testing and ON-OFF switching was performed following recovery from surgery and at one, two, and four months. After four months, the switch was left turned ON. Of the 30 patients using the implanted switch, 11 were dropped from the study and seven are still in progress. Of the 11 dropped from the study, four were due to switch problems and three were due to double blind protocol violations, i.e., the participants discovered the stimulus status. The remaining four were removed because of a broken lead, infection, or unrelated medical problems, or refusal to participate after implant. A preliminary analysis indicated that three-quarters of the patients have a demonstrable quantitative improvement during the time the stimulation was "ON." Three patients showed no significant change.

  3. Fort Hood Solar Total Energy Project. Volume II. Preliminary design. Part 2. System performance and supporting studies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1979-01-01

    The preliminary design developed for the Solar Total Energy System to be installed at Fort Hood, Texas, is presented. System performance analysis and evaluation are described. Feedback of completed performance analyses on current system design and operating philosophy is discussed. The basic computer simulation techniques and assumptions are described and the resulting energy displacement analysis is presented. Supporting technical studies are presented. These include health and safety and reliability assessments; solar collector component evaluation; weather analysis; and a review of selected trade studies which address significant design alternatives. Additional supporting studies which are generally specific to the installation site are reported. These include solar availability analysis; energy load measurements; environmental impact assessment; life cycle cost and economic analysis; heat transfer fluid testing; meteorological/solar station planning; and information dissemination. (WHK)

  4. Preliminary study of superconducting bulk magnets for Maglev

    Science.gov (United States)

    Fujimoto, Hiroyuki; Kamijo, Hiroki

    Recent development shows that melt-processed YBaCuO (Y123) or Rare Earth (RE)123 superconductors have a high Jc at 77 K and high magnetic field, leading to high field application as a superconducting quasi-permanent bulk magnet with the liquid nitrogen refrigeration. One of the promising applications is a superconducting magnet for the magnetically levitated (Maglev) train. We discuss a superconducting bulk magnet for the Maglev train in the aspect of a preliminary design of the bulk magnet and also processing for (L)REBaCuO bulk superconductors and their characteristic superconducting properties.

  5. Case study: the Argentina Road Safety Project: lessons learned for the decade of action for road safety, 2011-2020.

    Science.gov (United States)

    Raffo, Veronica; Bliss, Tony; Shotten, Marc; Sleet, David; Blanchard, Claire

    2013-12-01

    This case study of the Argentina Road Safety Project demonstrates how the application of World Bank road safety project guidelines focused on institution building can accelerate knowledge transfer, scale up investment and improve the focus on results. The case study highlights road safety as a development priority and outlines World Bank initiatives addressing the implementation of the World Report on Road Traffic Injury's recommendations and the subsequent launch of the Decade of Action for Road Safety, from 2011-2020. The case study emphasizes the vital role played by the lead agency in ensuring sustainable road safety improvements and promoting the shift to a 'Safe System' approach, which necessitated the strengthening of all elements of the road safety management system. It summarizes road safety performance and institutional initiatives in Argentina leading up to the preparation and implementation of the project. We describe the project's development objectives, financing arrangements, specific components and investment staging. Finally, we discuss its innovative features and lessons learned, and present a set of supplementary guidelines, both to assist multilateral development banks and their clients with future road safety initiatives, and to encourage better linkages between the health and transportation sectors supporting them.

  6. A study on safety assessment methodology for a vitrification plant

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Y. C.; Lee, G. S.; Choi, Y. C.; Kim, G. H. [Yonsei Univ., Seoul (Korea, Republic of)

    2002-03-15

    In this study, the technical and regulatory status of radioactive waste vitrification technologies in foreign and domestic plants is investigated and analyzed, and then significant factors are suggested which must be contained in the final technical guideline or standard for the safety assessment of vitrification plants. Also, the methods to estimate the stability of vitrified waste forms are suggested with property analysis of them. The contents and scope of the study are summarized as follows : survey of the status on radioactive waste vitrification technologies in foreign and domestic plants, survey of the characterization methodology for radioactive waste form, analysis of stability for vitrified waste forms, survey and analysis of technical standards and regulations concerned with them in foreign and domestic plants, suggestion of significant factors for the safety assessment of vitrification plants, submission of regulated technical standard on radioactive waste vitrification plats.

  7. Retrospective Study on the Efficacy and Safety of Quinacrine Sterilization

    Institute of Scientific and Technical Information of China (English)

    丁菊红; 陆卫群; 丁婉华; 朱红; 童建孙

    2000-01-01

    Objective To observe and evaluate the efficacy and safety of quinacrine sterilization.Methods A total of 572 cases of quinacrine sterilization preformed during the 4 years from 1993to 1997in Jiangsu and Guizhou Provinces were employed in this study. The efficacy and safety of quinacrine sterilization in those case were studied and evaluated, with 588 cases of surgical sterilization performed at the same time being the control group.Results Both groups were with identical demographic and gynecological characteristics. The result of multiple decrement life table analysis showed the 12th gross cumulative failure rates for quinacrine sterilization was 3. 13% and serious side effects occurred in only 2 cases accounting for O. 35%. One was ectopic pregnancy (20 months after treatment). The other was due to anaphylaxis in 10 minutes after the second insertion). No difference in the liver and nephic functions was detected and no suspected cancer cells or cancer cells were found in the two groups. 99. 6% of the 572 women interviewed accepted the quinacrine sterilization.Conclusions Quinacrine sterilization method is with high acceptability but comparatively low effectiveness. It has been proved to be a safe method of contraception in short-term. However, the safety of long-term still needs further study.

  8. PHOEBUS/UHTREX: a preliminary study of a low-cost facility for transient tests of LMFBR fuel

    Energy Technology Data Exchange (ETDEWEB)

    Kirk, W.L. (comp.)

    1976-08-01

    The results of a brief preliminary design study of a facility for transient nuclear tests of fast breeder reactor fuel are described. The study is based on the use of a reactor building originally built for the UHTREX reactor, and the use of some reactor hardware and reactor design and fabrication technology remaining from the Phoebus-2 reactor of the Rover nulcear rocket propulsion program. The facility is therefore currently identified as the PHOEBUS/UHTREX facility. This facility is believed capable of providing early information regarding fast reactor core accident energetics issues which will be very valuable to the overall LMFBR safety program. Facility performance in conjunction with a reference 127-fuel pin experiment is described. Low cost and early availability of the facility were emphasized in the selection of design features and parameters.

  9. EVALUATION OF SAFETY AND EFFECTIVENESS OF HYLAN GF-20 IN PATIENTS WITH KNEE OSTEOARTHRITIS IN REAL LIFE PRACTICE: PRELIMINARY RESULTS

    Directory of Open Access Journals (Sweden)

    G. V. Kuropatkin

    2016-01-01

    Full Text Available Combined conservative treatment of osteoarthritis includes intra-articular injections of hyaluronic acid. The paper presents the interim results of a prospective observational multicenter non-comparative study conducted in accordance with routine clinical practice to assess the safety and effectiveness of Hylan GF-20 in patients with knee osteoarthritis. The primary objective of the study is to assess walking and rest pain severity by WOMAC VA3.1 scale after 26 weeks and 52 weeks compared to the baseline. To date, 42 patients completed the study (71.43% women, 28.57% men, patients mean age is 59.79 years. After intraarticular injection of Hylan GF-20 patients were examined after 3, 6 and 12 months. After 3 months a positive clinical response was observed: pain severity decreased by 51.31% (p<0,001 on WOMAC A, joint stiffness decreased by 51.02% (p<0,001 on WOMAC B, daily life difficulties decreased by 42.03% (p<0,001 on WOMAC C. The same tendency was observed in the following periods. By week 52 pain severity reduced by 53.25% (p<0,001 on WOMAC A, joint stiffness by 41.63% (p<0,001 on WOMAC B, daily life difficulties -by 47.55% (p<0.001 on WOMAC C. Level of clinical response didn't correlate with the osteoarthritis stage. Therapy resulted in improvement of life quality of patients with knee osteoarthritis by 36% (p<0,001 according to the questionnaire EQ-5D. The general patients status according to physicians improved by 33.96% (p<0,001 on VAS, and by 45.91% (p<0,001 according to patients response on VAS. By week 52 of follow-up 11,90% of patients demonstrated a decrease in required concomitant therapy of osteoarthritis. Given the chronic nature of the osteoarthritis it's the most important that the therapeutic effect of Hylan GF-20 maintains until week 52. The above results confirm the efficiency of intraar-ticular injection of hyaluronic acid in patients with knee osteoarthritis especially in early disease stage.

  10. On Safety Management. A Frame of Reference for Studies of Safety Management with Examples From Non-Nuclear Contexts of Relevance for Nuclear Safety

    Energy Technology Data Exchange (ETDEWEB)

    Svensson, Ola; Salo, Ilkka; Allwin, Pernilla (Risk Analysis, Social and Decision Research Unit, Dept. of Psychology, Stockholm Univ., Stockholm (Sweden))

    2004-11-15

    A good knowledge about safety management from risk technologies outside the area of nuclear power may contribute to both broaden the perspectives on safety management in general, and point at new opportunities for improving safety measures within the nuclear industry. First, a theoretical framework for the study of safety management in general is presented, followed by three case studies on safety management from different non-nuclear areas with potential relevance for nuclear safety. The chapters are written as separate reports and can be read independently of each other. The nuclear industry has a long experience about the management of risky activities, involving all the stages from planing to implementation, both on a more generalized level and in the specific branches of activities (management, administration, operation, maintenance, etc.). Here, safety management is a key concept related to these areas of activities. Outside the field of nuclear power there exist a number of different non-nuclear risk technologies, each one with their own specific needs and experiences about safety management. The differences between the areas consist partly of the different experiences caused by the different technologies. Besides using own experiences in safety practices within the own areas of activities, it may be profitable to take advantage in knowledge and experiences from one area and put it in practice in another area. In order to facilitate knowledge transfer from one technological area to another it may be possible to adapt a common theoretical model, for descriptions and explanations, to the different technologies. Such a model should admit that common denominators for safety management across the areas might be identified and described with common concepts. Systems theory gives the opportunity to not only create models that are descriptive for events within the limits of a given technology, but also to generate knowledge that can be transferred to other

  11. On Safety Management. A Frame of Reference for Studies of Safety Management with Examples From Non-Nuclear Contexts of Relevance for Nuclear Safety

    Energy Technology Data Exchange (ETDEWEB)

    Svensson, Ola; Salo, Ilkka; Allwin, Pernilla (Risk Analysis, Social and Decision Research Unit, Dept. of Psychology, Stockholm Univ., Stockholm (Sweden))

    2004-11-15

    A good knowledge about safety management from risk technologies outside the area of nuclear power may contribute to both broaden the perspectives on safety management in general, and point at new opportunities for improving safety measures within the nuclear industry. First, a theoretical framework for the study of safety management in general is presented, followed by three case studies on safety management from different non-nuclear areas with potential relevance for nuclear safety. The chapters are written as separate reports and can be read independently of each other. The nuclear industry has a long experience about the management of risky activities, involving all the stages from planing to implementation, both on a more generalized level and in the specific branches of activities (management, administration, operation, maintenance, etc.). Here, safety management is a key concept related to these areas of activities. Outside the field of nuclear power there exist a number of different non-nuclear risk technologies, each one with their own specific needs and experiences about safety management. The differences between the areas consist partly of the different experiences caused by the different technologies. Besides using own experiences in safety practices within the own areas of activities, it may be profitable to take advantage in knowledge and experiences from one area and put it in practice in another area. In order to facilitate knowledge transfer from one technological area to another it may be possible to adapt a common theoretical model, for descriptions and explanations, to the different technologies. Such a model should admit that common denominators for safety management across the areas might be identified and described with common concepts. Systems theory gives the opportunity to not only create models that are descriptive for events within the limits of a given technology, but also to generate knowledge that can be transferred to other

  12. Safety and efficacy of aneurysm treatment with WEB: results of the WEBCAST study.

    Science.gov (United States)

    Pierot, Laurent; Costalat, Vincent; Moret, Jacques; Szikora, Istvan; Klisch, Joachim; Herbreteau, Denis; Holtmannspötter, Markus; Weber, Werner; Januel, Anne-Christine; Liebig, Thomas; Sychra, Vojtech; Strasilla, Christoph; Cognard, Christophe; Bonafé, Alain; Molyneux, Andrew; Byrne, James V; Spelle, Laurent

    2016-05-01

    OBJECT WEB is an innovative intrasaccular treatment for intracranial aneurysms. Preliminary series have shown good safety and efficacy. The WEB Clinical Assessment of Intrasaccular Aneurysm Therapy (WEBCAST) trial is a prospective European trial evaluating the safety and efficacy of WEB in wide-neck bifurcation aneurysms. METHODS Patients with wide-neck bifurcation aneurysms for which WEB treatment was indicated were included in this multicentergood clinical practices study. Clinical data including adverse events and clinical status at 1 and 6 months were collected and independently analyzed by a medical monitor. Six-month follow-up digital subtraction angiography was also performed and independently analyzed by a core laboratory. Success was defined at 6 months as complete occlusion or stable neck remnant, no worsening in angiographic appearance from postprocedure, and no retreatment performed or planned. RESULTS Ten European neurointerventional centers enrolled 51 patients with 51 aneurysms. Treatment with WEB was achieved in 48 of 51 aneurysms (94.1%). Adjunctive implants (coils/stents) were used in 4 of 48 aneurysms (8.3%). Thromboembolic events were observed in 9 of 51 patients (17.6%), resulting in a permanent deficit (modified Rankin Scale [mRS] Score 1) in 1 patient (2.0%). Intraoperative rupture was not observed. Morbidity (mRS score > 2) and mortality were 2.0% (1 of 51 patients, related to rupture status on entry to study) and 0.0% at 1 month, respectively. Success was achieved at 6 months in 85.4% of patients treated with WEB: 23 of 41 patients (56.1%) had complete occlusion, 12 of 41 (29.3%) had a neck remnant, and 6 of 41 (14.6%) had an aneurysm remnant. CONCLUSIONS The WEBCAST study showed good procedural and short-term safety of aneurysm treatment with WEB and good 6-month anatomical results.

  13. Metals in wheat flour; comparative study and safety control.

    Science.gov (United States)

    Tejera, Raquel L; Luis, G; González-Weller, Dailos; Caballero, José M; Gutiérrez, Angel J; Rubio, Carmen; Hardisson, Arturo

    2013-01-01

    Cereal industry and its derived products have a big economic and social importance worldwide. Therefore, as wheat flour is a commodity for all bread and bakery industry, it is safety is of high nutrition and toxicological interest. In this investigation we intend to study and determine the content of twelve metals in 50 samples of wheat flour coming from a wheat flour industry. Macro elements sodium, potassium magnesium and calcium, micro elements manganese, iron, copper, zinc, chrome and nickel as well as toxic trace elements cadmium and lead have been analysed. The estimated diary intake of each metal and their contribution in percentage terms to the RDI (macro and micro elements) and to the PTWI (toxic elements) has been determined. Contribution of Cd and Pb to the PTWI was very low, a fact that shows safety in this wheat flour concerning toxic metals. Copyright © AULA MEDICA EDICIONES 2013. Published by AULA MEDICA. All rights reserved.

  14. Motorcycle safety device investigation: A case study on airbags

    Indian Academy of Sciences (India)

    A Chawla; S Mukherjee

    2007-08-01

    The present standard for assessing the effectiveness of safety measures for motorcycle riders defined in ISO 13232 is unique and it incorporates evaluation by computer simulation supplemented by full-scale crash tests. This report describes the process of using FE (Finite Element) simulations to investigate safety options for motorcycle riders. The experience of developing finite element models acceptable as per ISO 13232 standards has been described. The variation in dummy head accelerations on impact with inflating airbags has been studied in an environment acceptable as per ISO 13232 standards. Based on the simulations, it may be concluded that inflating airbags in motorcycles do not pose a significant injury threat.

  15. Metals in wheat flour: comparative study and safety control

    Directory of Open Access Journals (Sweden)

    Raquel L. Tejera

    2013-04-01

    Full Text Available Cereal industry and its derived products have a big economic and social importance worldwide. Therefore, as wheat flour is a commodity for all bread and bakery industry, it is safety is of high nutrition and toxicological interest. In this investigation we intend to study and determine the content of twelve metals in 50 samples of wheat flour coming from a wheat flour industry. Macro elements sodium, potassium magnesium and calcium, micro elements manganese, iron, copper, zinc, chrome and nickel as well as toxic trace elements cadmium and lead have been analysed. The estimated diary intake of each metal and their contribution in percentage terms to the RDI (macro and micro elements and to the PTWI (toxic elements has been determined. Contribution of Cd and Pb to the PTWI was very low, a fact that shows safety in this wheat flour concerning toxic metals.

  16. A study on the safety evaluation of concentrated tritium storage

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K. J.; Kim, K. K.; Lee, S. Y.; Lee, Y. E.; Hong, D. S.; Jung, H. Y.; Song, M. C.; Hwang, K. H.; Kim, S. I.; Yook, D. S.; Sheen, J. J. [Korea Advanced Institute of Science and Technology, Taejeon (Korea)

    2001-03-01

    In this study, hazards of hydrogen and the risk due to storage of tritium are reviewed. The safety related factors are suggested in terms of classification of hydrogen hazards and problems related to the tritium storage. The major design parameters of the vessel of foreign countries for the storage and transport of tritium are reviewed. By review of major safety parameters related to the tritium storage, the results of this study can be applied and helpful to the development and design of tritium storage vessel in Korea. Also, the results can be useful at design of the tritium treatment facility. The integrity of tritium storage vessel material was evaluated with considering the embrittlement of metal material in hydrogen environment. The tritium storage is one of the most important problems for the safety of tritium removal facility. The research for tritium storage could be divided into two parts, one is for the metal getter of tritium and the other is for the integrity of tritium storage vessel. Especially, the integrity of tritium storage vessel is up to the tritium embrittlement of vessel materials, for tritium vessel is mostly made of metal material. In this work, the evaluation of the tritium embrittlement for the tritium storage vessel material is performed with the equipment that is made for high temperature and high vacuum. 33 refs., 56 figs., 23 tabs. (Author)

  17. Preliminary study on the RF tuning of CSNS DTL

    Science.gov (United States)

    Yin, Xue-Jun; Li, A.-Hong; Xiao, Yong-Chuang; Chen, Qiang; Liu, Hua-Chang; Gong, Ke-Yun; Fu, Shi-Nian

    2014-02-01

    In the R&D of the CSNS Drift Tube Linac (DTL), the first unit tank with 28 drift tubes has been developed. The axial accelerating field is ramped from 2.2 MV/m to 3.1 MV/m in this tank. The required field flatness is less than ±2% with the standard deviation of 1% for the beam dynamics; the field stability should be less than 1% for machine stable operation. After successful alignment, RF tuning was carried out focusing on the field profile measurement. Four slug tuners and eleven post couplers were applied in this procedure. The ramped field and required stability had been achieved by fine adjustment of the slug tuners and post couplers. In this paper, the preliminary tuning results are presented and discussed.

  18. Preliminary Study on the RF tuning of CSNS DTL

    CERN Document Server

    Yin, Xuejun; Xiao, Yongchuang; Chen, Qiang; Liu, Huachang; Gong, Keyun; Fu, Shinan

    2013-01-01

    In the R&D of the CSNS Drift Tube Linac (DTL), the first unit tank with 28 drift tubes has been developed. The axial accelerating field is ramped from 2.2MV/m to 3.1MV/m in this tank. The required field flatness is less than 2 % with the standard deviation of 1 % for the beam dynamics. And the field stability should be less than 1% for machine stable operation. After the successful alignment, the RF tuning was carried out focusing on the field profile measurement. Four slug tuners and 11 post couplers were applied in this procedure. The ramped filed and required stability had been achieved by fine adjustment of the slug tuners and post couplers. In this paper, the preliminary tuning results are presented and discussed.

  19. Treatment of Retinopathy of Prematurity with topical ketorolac tromethamine: a preliminary study

    Directory of Open Access Journals (Sweden)

    Cafferata Maria

    2004-08-01

    Full Text Available Abstract Background Retinopathy of Prematurity (ROP is a common retinal neovascular disorder of premature infants. It is of variable severity, usually heals with mild or no sequelae, but may progress to blindness from retinal detachments or severe retinal scar formation. This is a preliminary report of the effectiveness and safety of a new and original use of topical ketorolac in preterm newborn to prevent the progression of ROP to the more severe forms of this disease. Methods From January 2001 to December 2002, all fifty nine preterm newborns with birthweight less than 1250 grams or gestational age less than 30 weeks of gestational age admitted to neonatal intensive care were eligible for treatment with topical ketorolac (0.25 milligrams every 8 hours in each eye. The historical comparison group included all 53 preterm newborns, with the same inclusion criteria, admitted between January 1999 and December 2000. Results Groups were comparable in terms of weight distribution, Apgar score at 5 minutes, incidence of sepsis, intraventricular hemorrhage and necrotizing enterocolitis. The duration of oxygen therapy was significantly longer in the control group. In the ketorolac group, among 43 children that were alive at discharge, one (2.3% developed threshold ROP and cryotherapy was necessary. In the comparison group 35 children survived, and six child (17% needed cryotherapy (Relative Risk 0.14, 95%CI 0.00 to 0.80, p = 0.041. Adjusting by duration of oxygen therapy did not significantly change these results. Adverse effects attributable to ketorolac were not detected. Conclusions This preliminary report suggests that ketorolac in the form of an ophthalmic solution can reduce the risk of developing severe ROP in very preterm newborns, without producing significant adverse side effects. These results, although promising, should be interpreted with caution because of the weakness of the study design. This is an inexpensive and simple intervention that

  20. The assessment of seismic hazard for Gori, (Georgia) and preliminary studies of seismic microzonation

    Science.gov (United States)

    Gogoladze, Z.; Moscatelli, M.; Giallini, S.; Avalle, A.; Gventsadze, A.; Kvavadze, N.; Tsereteli, N.

    2016-12-01

    Seismic risk is a crucial issue for South Caucasus, which is the main gateway between Asia and Europe. The goal of this work is to propose new methods and criteria for defining an overall approach aimed at assessing and mitigating seismic risk in Georgia. In this reguard seismic microzonation represents a highly useful tool for seismic risk assessmentin land management, for design of buildings or structures and for emergency planning.Seismic microzonation assessment of local seismic hazard,which is a component of seismicity resulting from specific local characteristics which cause local amplification and soil instability, through identification of zones with seismically homogeneous behavior. This paper presents the results of preliminary study of seismic microzonation of Gori, Georgia. Gori is and is located in the Shida Kartli region and on both sides of Liachvi and Mtkvari rivers, with area of about 135 km2around the Gori fortress. Gori is located in Achara-Trialeti fold-thrust belt, that is tectonically unstable. Half of all earthquakes in Gori area with magnitude M≥3.5 have happened along this fault zone and on basis of damage caused by previous earthquakes, this territory show the highest level of risk (the maximum value of direct losses) in central part of the town. The seismic microzonation map of level 1 for Gori was carried out using: 1) Already available data (i.e., topographic map and boreholes data), 2) Results of new geological surveys and 3) Geophysical measurements (i.e., MASW and noise measurements processed with HVSR technique). Our preliminary results highlight the presence of both stable zones susceptible to local amplifications and unstable zones susceptible to geological instability. Our results are directed to establish set of actions aimed at risk mitigation before initial onset of emergency, and to management of the emergency once the seismic event has occurred. The products obtained, will contain the basic elements of an integrated system

  1. 幼儿园安全教育初探%A Preliminary Approach to Safety Education in Kinder-garten

    Institute of Scientific and Technical Information of China (English)

    林艳

    2013-01-01

    The healthy development in childhood is the funda-ment of a kid. It is the unavoidable responsibility of a kinder-garten to focus on safety education and provide security for kids. Our kindergarten has tried the following measures for the educa-tion of child safety, setting up an environment for the safety edu-cation, offering"weekly, monthly and quarterly"activities, order-ing safety drill regularly, and strengthening communications be-tween the family and kindergarten. Through the above measures, we have improved the self-care awareness and behavior of chil-dren effectively and given a security assurance for children.%幼儿时期的健康发展是幼儿成长的根本,注重安全教育,为幼儿提供安全的保障是幼儿园不可推卸的责任。我园在对幼儿的安全教育方面做出了以下尝试:创设安全教育的环境、开展“三个一”的安全教育活动、定期开展安全演习以及加强家园沟通配合。通过以上措施,有效地提升幼儿的安全自护意识及行为,使幼儿得到真正的安全保障。

  2. ROAD ACCIDENT AND SAFETY STUDY IN SYLHET REGION OF BANGLADESH

    Directory of Open Access Journals (Sweden)

    B. K. BANIK

    2011-08-01

    Full Text Available Roads, highways and streets are fundamental infrastructure facilities to provide the transportation for passenger travel and goods movement from one place to another in Sylhet, north–eastern division of Bangladesh with rapid growth of road vehicle, being comparatively developed economic tourist prone area faces severe road traffic accident. Such severe road accidents cause harsh safety hazards on the roads of Sylhet area. This research work presents an overview of the road traffic accident and degraded road safety situation in Sylhet zone which in particular, discusses the key road accident problem characteristics identifying the hazardous roads and spots, most responsible vehicles and related components, conditions of drivers and pedestrians, most victims of accident, effects of accident on society, safety priorities and options available in Sylhet. In this regard, a comprehensive questionnaire survey was conducted on the concerned groups of transportation and detailed accident data was collected from a popular local newspaper. Analysis of the study reveals that Dhaka- Sylhet highway is the most hazardous in road basis and Sylhet Sador thana is the most vulnerable in thana basis in Sylhet region.

  3. Pharmaceuticals Safety Practices-A Comparative Pilot Study

    Science.gov (United States)

    Tawfik, Kamilia A.; Jabeen, Arshia

    2013-01-01

    Introduction The safety of medicine is essential for the safety of patients. Inappropriate drug storage, expiration dates, sharing prescription drugs, self medication habits and misuse of some drugs are contributing factors affecting medication safety. One or more of these factors may lead to serious health complications and even death. Objectives The purpose of this study was to highlight the common errors and pharmaceutical malpractices that people usually engage in on a daily basis and to correlate these to culture, gender and educational levels. This may spread awareness in an easy and understandable manner and provide certain guidelines to drug consumers ensuring that pharmaceutical preparations are used correctly and safely. Methods Two hundred questionnaires were randomly distributed in two countries; Saudi Arabia and India. The collected data were statistically analyzed. Outcomes and conclusion Results showed that alarming percentages of various participants were using pharmaceuticals inappropriately due to carelessness, unawareness or intentional mistakes. Therefore, active participation by health care professionals is essential for the prevention of drug misuse. Increasing population awareness about self medication, products expiration, pharmaceuticals labels and optimum storage conditions would minimize the adverse effects and may even be life saving. PMID:24533025

  4. EPR safety. Consideration of the internal and external hazards in the safety studies; Surete du reacteur EPR. Prise en compte des agressions internes et externes dans les etudes de surete EPR

    Energy Technology Data Exchange (ETDEWEB)

    Gueguin, H. [Electricite de France (EDF-DIN), Centre National d' Equipement Nucleaire, Service Controle Commande, 92 - Montrouge (France)

    2008-04-15

    The author presents the main points of the Preliminary Safety Report of EDF on the EPR reactor safety. It concerns the considerations of the internal (fire, flood, explosions, pipes failures) and external (earthquakes, airplane falls, explosions, exceptional natural disasters, extreme meteorological conditions) damages. It presents how the safety report takes into account the aggression. (A.L.B.)

  5. [European Union Network for Patient Safety and Quality of Care (PASQ). Development and preliminary results in Europe and in the Spanish National Health System].

    Science.gov (United States)

    Agra-Varela, Y; Fernández-Maíllo, M; Rivera-Ariza, S; Sáiz-Martínez-Acitorez, I; Casal-Gómez, J; Palanca-Sánchez, I; Bacou, J

    2015-01-01

    The joint action, European Union Network for Patient Safety and Quality of Care: PaSQ, aims to promote patient safety (PS) in the European Union (EU) and to facilitate the exchange of experiences among Member States (MS) and stakeholders on issues related to quality of care, PS, and patient involvement. The development and preliminary results are presented here, especially as regards the Spanish National Health System (SNHS). PaSQ is developed through 7 work packages, primarily aimed at sharing good practices (GP), which were identified using specific questionnaires and selected by means of explicit criteria, as well as to implement safe clinical practices (SCP) of proven effectiveness and agreed among MS. A total of 482 GP (39% provided by Spanish professionals) were identified. The 34 events organised in the EU, 11 including Spanish participation, facilitate sharing these practices. A total of 194 Health Care centres (49% in Spain) are implementing SCP (hand hygiene, safe surgery, medication reconciliation, and paediatric early warning scores) ACHIEVEMENTS AND FUTURE PERSPECTIVES: PaSQ is making it possible to strengthen collaboration between organizations and professionals at EU and SNHS level regarding PS and quality of care. Copyright © 2015 SECA. Published by Elsevier Espana. All rights reserved.

  6. Premarket safety and efficacy studies for ADHD medications in children.

    Directory of Open Access Journals (Sweden)

    Florence T Bourgeois

    Full Text Available Attention-deficit hyperactivity disorder (ADHD is a chronic condition and pharmacotherapy is the mainstay of treatment, with a variety of ADHD medications available to patients. However, it is unclear to what extent the long-term safety and efficacy of ADHD drugs have been evaluated prior to their market authorization. We aimed to quantify the number of participants studied and their length of exposure in ADHD drug trials prior to marketing.We identified all ADHD medications approved by the Food and Drug Administration (FDA and extracted data on clinical trials performed by the sponsor and used by the FDA to evaluate the drug's clinical efficacy and safety. For each ADHD medication, we measured the total number of participants studied and the length of participant exposure and identified any FDA requests for post-marketing trials.A total of 32 clinical trials were conducted for the approval of 20 ADHD drugs. The median number of participants studied per drug was 75 (IQR 0, 419. Eleven drugs (55% were approved after <100 participants were studied and 14 (70% after <300 participants. The median trial length prior to approval was 4 weeks (IQR 2, 9, with 5 (38% drugs approved after participants were studied <4 weeks and 10 (77% after <6 months. Six drugs were approved with requests for specific additional post-marketing trials, of which 2 were performed.Clinical trials conducted for the approval of many ADHD drugs have not been designed to assess rare adverse events or long-term safety and efficacy. While post-marketing studies can fill in some of the gaps, better assurance is needed that the proper trials are conducted either before or after a new medication is approved.

  7. 76 FR 52330 - Safety and Occupational Health Study Section (SOHSS), National Institute for Occupational Safety...

    Science.gov (United States)

    2011-08-22

    ... (SOHSS), National Institute for Occupational Safety and Health (NIOSH) In accordance with section 10(a)(2... standard grants review and funding cycles pertaining to research issues in occupational safety and health... support more focused research projects, which will lead to improvements in the delivery of...

  8. Development of an X-ray installation for the study of secondary electrons: preliminary measurements and calculations

    Energy Technology Data Exchange (ETDEWEB)

    Baguena, A.; Shaw, M.; Williart, A. [Universidad Nacional de Educacion a Distancia, Dpto. Fisica de los Materiales, Madrid (Spain); Baguena, A. [Consejo de Seguridad Nuclear, Madrid (Spain); Garcia, G. [Instituto de Matematicas y Fisica Fundamental, Consejo Superior de Investigaciones Cientificas, Madrid (Spain)

    2006-07-01

    We describe the calculations and preliminary measures made for the installation of a X-ray generator tube. This device is going to be used for the secondary electron production from photonic primary radiation of up to 125 keV. With this experimental system, we will study the energetic and space distribution of produced secondary electrons by obtaining its spectrum of energies and its angular distribution. This method of measurement is going to be applied in different targets of radiological, environmental and biological interest. Calculations in the present article include: theoretical yield of X-rays production of the designed equipment, necessary shielding for the radiological safety of the installation staff, and an estimated dose due to their use. Characteristics of the installation and the equipment are described with this purpose. (author)

  9. The association between EMS workplace safety culture and safety outcomes.

    Science.gov (United States)

    Weaver, Matthew D; Wang, Henry E; Fairbanks, Rollin J; Patterson, Daniel

    2012-01-01

    Prior studies have highlighted wide variation in emergency medical services (EMS) workplace safety culture across agencies. To determine the association between EMS workplace safety culture scores and patient or provider safety outcomes. We administered a cross-sectional survey to EMS workers affiliated with a convenience sample of agencies. We recruited these agencies from a national EMS management organization. We used the EMS Safety Attitudes Questionnaire (EMS-SAQ) to measure workplace safety culture and the EMS Safety Inventory (EMS-SI), a tool developed to capture self-reported safety outcomes from EMS workers. The EMS-SAQ provides reliable and valid measures of six domains: safety climate, teamwork climate, perceptions of management, working conditions, stress recognition, and job satisfaction. A panel of medical directors, emergency medical technicians and paramedics, and occupational epidemiologists developed the EMS-SI to measure self-reported injury, medical errors and adverse events, and safety-compromising behaviors. We used hierarchical linear models to evaluate the association between EMS-SAQ scores and EMS-SI safety outcome measures. Sixteen percent of all respondents reported experiencing an injury in the past three months, four of every 10 respondents reported an error or adverse event (AE), and 89% reported safety-compromising behaviors. Respondents reporting injury scored lower on five of the six domains of safety culture. Respondents reporting an error or AE scored lower for four of the six domains, while respondents reporting safety-compromising behavior had lower safety culture scores for five of the six domains. Individual EMS worker perceptions of workplace safety culture are associated with composite measures of patient and provider safety outcomes. This study is preliminary evidence of the association between safety culture and patient or provider safety outcomes.

  10. A PRELIMINARY STUDY OF EXPERT SYSTEM FOR MINING UNDER STRUCTURES

    Institute of Scientific and Technical Information of China (English)

    吴侃; 何国清; 曹立明

    1991-01-01

    The expert system MUST (Mining Under Structures) shown in this paper and established by the authors is a preliminary expert system to solve the policy-making problems formining under structures by means of computers instead of humanbeing. Based on the experience of relative experts,the authors established a knowledge base about the minings under structures ,researched into reasonable method to simulate thinking processes of human experts when they are solvin8 the problems, established the network of an expert system and named it'MUST system'MUST system uses the method of the structural system analysis approach. A kind of methods of Turbo Prolog and Fortran 77 language alternations is designed to meet the needs of exchange information within the MUST system. Based on this kind of methods MUST system has been constructed and realised on IBM-PC computer. For verifying the correctness. suitability and reliablity of MUST system,some practical examples of minings under structures were tentatively solved using MUST system ,whose results are satisfactory.

  11. The Myres Hill remote sensing intercomparison study: preliminary results

    Science.gov (United States)

    Clive, P. J. M.; Chindurza, I.; Ravey, I.; Bass, J.; Boyle, R. J.; Jones, P.; Lang, S. J.; Bradley, S.; Hay, L.; Oldroyd, A.; Stickland, M.

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  12. Preliminary study of a dispersed fringe type sensing system

    Institute of Scientific and Technical Information of China (English)

    Yong Zhang; Gen-Rong Liu; Yue-Fei Wang; Ye-Ping Li; Ya-Jun Zhang; Liang Zhang

    2009-01-01

    Telescopes with large aspherical primary mirrors collect more light and are therefore sought after by astronomers. Instead of using a single large one-piece mirror, smaller segments can be assembled into a useable telescopic primary. Because the seg-ments must fit together to create the effect of a single mirror, segmented optics present unique challenges to the fabrication and testing that are absent in monolithic optics. A dispersed fringe sensor (DFS) using a broadband point source is an efficient method for cophasing and is also highly automated and robust. Unlike the widely adopted Shack-Hartmann Wavefront sensor and curvature wavefront sensor with edge sensors for cali-bration of relative pistons, DFS can estimate the piston between segments by only using the spectrum formed by the transmissive grating's dispersion, and therefore can replace the edge sensors, which are difficult to calibrate. We introduce the theory of the DFS and Dispersed Hartmann Sensor (DHS) for further utilization of the coarse phasing method of DFS. According to the theory, we bring out the preliminary system design of the cophas-ing experimental system based on DFS and DHS which is now established in our institute. Finally, a summary is reached.

  13. Preliminary study on mechanics-based rainfall kinetic energy

    Directory of Open Access Journals (Sweden)

    Yuan Jiuqin Ms.

    2014-09-01

    Full Text Available A raindrop impact power observation system was employed to observe the real-time raindrop impact power during a rainfall event and to analyze the corresponding rainfall characteristics. The experiments were conducted at different simulated rainfall intensities. As rainfall intensity increased, the observed impact power increased linearly indicating the power observation system would be satisfactory for characterizing rainfall erosivity. Momentum is the product of mass and velocity (Momentum=MV, which is related to the observed impact power value. Since there is no significant difference between momentum and impact power, observed impact power can represent momentum for different rainfall intensities. The relationship between momentum and the observed impact power provides a convenient way to calculate rainfall kinetic energy. The value of rainfall kinetic energy based on the observed impact power was higher than the classic rainfall kinetic energy. The rainfall impact power based kinetic energy and the classic rainfall kinetic energy showed linear correlation, which indicates that the raindrop impact power observation system can characterize rainfall kinetic energy. The article establishes a preliminary way to calculate rainfall kinetic energy by using the real-time observed momentum, providing a foundation for replacing the traditional methods for estimating kinetic energy of rainstorms.

  14. Utilization of Optimal Study Design for Maternal and Fetal Sheep Propofol Pharmacokinetics Study: A Preliminary Study

    Science.gov (United States)

    Sherwin, Catherine M. T.; Ngamprasertwong, Pornswan; Sadhasivam, Senthilkumar; Vinks, Alexander A.

    2017-01-01

    Multiple blood samples are generally required for measurement of pharmacokinetic (PK) parameters. D-optimal design is a popular and frequently used approach for determination of sampling time points in order to minimize the number of samples, while optimizing the estimation of PK parameters. Optimal design utilizing ADAPT (v5, BSR, University of Southern California, Los Angeles) developed a sparse sampling strategy to determine measurement of propofol in pregnant sheep. Propofal was administered as supplemental anesthetic agent to inhalation anesthesia to mimic anesthesia for open fetal surgery. In our preliminary study, propofol 3 mg/kg was given as a bolus to the ewe, followed by propofol infusion at rate 450 mcg/kg/min for 60 minutes, then decreased to 75 mcg/kg/min for 90 more minutes and then ceased. A three compartment model described the PK parameters with the fetus assumed as the third compartment. Initially, sampling times were chosen from thirteen time points as previously stated in the literature. Using priori propofol PK estimates, the final 9 sample time points were proposed in an optimal design with a change in infusion rate occurring between 65 and 75 minutes and sampling proposed at 5, 15, 25, 65, 75, 100, 110, 150, and 180 minutes. D-optimal design optimized the number and timing of samplings, which led to a reduction of cost and man power in the study protocol while preserving the ability to estimate propofol PK parameters in the maternal and fetal sheep model. Initial evaluation of samples collected from three sheep using the optimal design strategy confirmed the performance of the design in obtaining effective PK parameter estimates. PMID:24219004

  15. Space station crew safety alternatives study. Volume 3: Safety impact of human factors

    Science.gov (United States)

    Rockoff, L. A.; Raasch, R. F.; Peercy, R. L., Jr.

    1985-01-01

    The first 15 years of accumulated space station concepts for Initial Operational Capability (IOC) during the early 1990's was considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris. Of particular interest here is volume three (of five volumes) pertaining to the safety impact of human factors.

  16. A study on Impact of Safety Culture on Safety Behavior: Moderating effect of Prevention Focus

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Sun Chul; Jung, Su Jin; Choi, Young Sung [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    In modern society, it has been acknowledged that disasters caused by civilization became inevitable. With growing attention to role of human as one component of the system to cope with accident to prevent disasters, various efforts have been deployed to keep safety. Most of the industries with high hazard have adopted the term as their banner in the efforts to promote safety in their installations and operations. Recently, the Fukushima nuclear power plants(NPPs) accident happened in Japan in 2011 resulted in great impact over the world and have highlighted the importance of safety culture again.

  17. Preliminary modelling study of ice accretion on wind turbines

    DEFF Research Database (Denmark)

    Pedersen, Marie Cecilie; Yin, Chungen

    2014-01-01

    One of the main challenges associated with cold-climate wind energy is icing on wind turbines and a series of icing-induced problems such as production loss, blade fatigue and safety issues. Because of the difficulties with on-site measurements, simulations are often used to understand and predict...... icing events. In this paper, a new methodology for prediction of icing-induced production loss is proposed, from which the fundamentals of ice accretion on wind turbines can be better understood and the operational production losses can be more reliably predicted. Computational fluid dynamics (CFD......) modelling of ice accretion on wind turbines is also performed for different ice events, resulting in a reliable framework for CFD-based ice accretion modelling which is one of the key elements in the new methodology....

  18. Preliminary design studies for a 100 MW Energy Amplifier prototype

    CERN Document Server

    Abánades, A

    2000-01-01

    The Energy Amplifier (EA) is a new concept of fission system based on a subcritical assembly sustained with the neutrons generated by proton beam impact on a heavy element (spallation). This concept, proposed by the Nobel Laureate C. Rubbia (Rubbia, 1995), has remarkable capabilities in the nuclear energy field. First, it can be used to transmute radioactive wastes with a high efficiency alleviating the requirements of the geological repositories, and, second, it provides a massive energy source with the intrinsic safety derived from the use of a subcritical system and an almost null production of long-lived radioactive wastes. EA concept principles have been successfully tested by two experiments at CERN: FEAT (Andriamonge, 1995), that proved there is a net energy gain, by comparing the energy needed by the accelerator with the generated one by fission in the subcritical system. The second experiment, TARC (Abanades, 1997; Arnould, 1999) demonstrated the capability to transmute radioactive elements. The next...

  19. 黄岛石化区消防安全初评估%Preliminary assessment of the fire safety in HuangDao petrochemical zone

    Institute of Scientific and Technical Information of China (English)

    李林宏; 余浩

    2011-01-01

    characteristics of tank farm, stabilized high pressure fire water system, hazardous chemicals safety assessment, the fire safety about hazardous chemicals process plant and hazardous chemicals storage tanks were preliminary assessed, then some recommendations and solution were given to fire safety.

  20. Preliminary safety analysis of a PBMR supplying process heat to a co-located ethylene production plant

    Energy Technology Data Exchange (ETDEWEB)

    Scarlat, Raluca O., E-mail: rscarlat@nuc.berkeley.edu [University of California Berkeley, Nuclear Engineering, 4118 Etcheverry Hall, Berkeley, CA 94720 (United States); Cisneros, Anselmo T. [University of California Berkeley, Nuclear Engineering, 4118 Etcheverry Hall, Berkeley, CA 94720 (United States); Koutchesfahani, Tawni [University of California, Chemical and Biomolecular Engineering, 201 Gilman Hall, Berkeley, CA 94720 (United States); Hong, Rada; Peterson, Per F. [University of California Berkeley, Nuclear Engineering, 4118 Etcheverry Hall, Berkeley, CA 94720 (United States)

    2012-10-15

    This paper considers the safety analysis and licensing approach for co-locating a pebble bed modular reactor (PBMR) to provide process heat to an ethylene production unit. The PBMR is an advanced nuclear reactor design that provides 400 MW of thermal energy. Ethylene production is an energy intensive process that utilizes large gas furnaces to provide the heat for the process. Coupling a PBMR with an ethylene production plant would open a new market for nuclear power, and would provide the chemical industry with a cleaner power source, helping to achieve the Clean Air Act standards, and eliminating the 0.5 ton of CO{sub 2} emissions per ton of produced ethylene. Our analysis uses the Chevron Phillips chemical plant in Sweeney, TX as a prototypical site. The plant has four ethylene production trains, with a total power consumption of 2.4 GW, for an ethylene output of 3.7 million tons per year, 4% of the global ethylene production capacity. This paper proposes replacement of the gas furnaces by low-emission PBMR modules, and presents the safety concerns and risk mitigation and management options for this coupled system. Two coupling design options are proposed, and the necessary changes to the design basis events and severe accidents for the PBMR licensing application are discussed. A joint effort between the chemical and the nuclear entities to optimize the coupling design, establish preventive maintenance procedures, and develop emergency response plans for both of the units is recommended.

  1. A Study on the Enterprises' Safety Management System

    Institute of Scientific and Technical Information of China (English)

    王春芳; Zhulingyun

    2010-01-01

    1. The causes of safety issues in production In general, there are many reasons caused safety risks in production, some are material factors and the others are human's factors. 1) The safety awareness level is low Many local government officers put economic development on first priority,ignoring the importance of safety in production. Especially in recent years,many efforts are made to increase investment;a number of preferential policies being made, which lead to the establishment of many industrial parks.

  2. Hybrid reactor safety study. Annual report, October 1, 1978-September 30, 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    A preliminary generic safety evaluation of the fusion-fission hybrid reactor concept has been performed and a hybrid reactor safety program plan for guiding future safety work has been proposed. The emphasis of the work was limited to accident analysis where the main concern is for the health and safety of the public. Major radioactive sources in the hybrid were identified and their inventories compared to those of fission reactors. The means for accidental release of radioactivity to the public were identified, as were the barriers which preclude such accidental releases. Consequence analyses of hypothetical bounding accidents potentially defining the upper bound envelope of risk/consequence to the population and environment surrounding the hybrid site were performed.

  3. Study on the efficacy of the safety incentive mechanisms

    Institute of Scientific and Technical Information of China (English)

    Tian Shui-cheng; LI Hong-xia; Feng Chang-gen

    2001-01-01

    Safety Incentive mechanism and corresponding motivation avenues are helpful and important for the scientific safety management in coal mine. With the help of modem systematic analysis method, the effcacy of safety incentive mechanisms is discussed in detail. The research shows that more effective avenue to reduce accident is to differently use motivation measures in practice.

  4. Towards a Czech Road Safety Information System : a feasibility study.

    NARCIS (Netherlands)

    Craen, S. de & Wegman, F.

    2003-01-01

    The Czech Republic aims at improving its road safety and in the last years it achieved significant successes in reducing the number of road traffic casualties. Increasingly, road safety measures have to be taken in an effor to lower the number of accidents. A Road Safety Information System (RSIS), w

  5. Preliminary results from a field experiment on e-bike safety: speed choice and mental workload for middle-aged and elderly cyclists

    NARCIS (Netherlands)

    Twisk, D.A.M.; Boele, M.J.; Vlakveld, W.P.; Christoph, M.; Sikkema, R.; Remij, R.; Schwab, A.L.

    2013-01-01

    To study the safety of e-bikes for the elderly, an experimental field study was conducted, using instrumented bicycles and comparing two age groups: older cyclists, n= 29, mean age = 70, SD = 4.2 and middle-aged cyclists, n = 29, mean age = 38, SD = 4.3. All were regular cyclists. They rode a fixed

  6. Preliminary results from a field experiment on e-bike safety: speed choice and mental workload for middle-aged and elderly cyclists

    NARCIS (Netherlands)

    Twisk, D.A.M.; Boele, M.J.; Vlakveld, W.P.; Christoph, M.; Sikkema, R.; Remij, R.; Schwab, A.L.

    2013-01-01

    To study the safety of e-bikes for the elderly, an experimental field study was conducted, using instrumented bicycles and comparing two age groups: older cyclists, n= 29, mean age = 70, SD = 4.2 and middle-aged cyclists, n = 29, mean age = 38, SD = 4.3. All were regular cyclists. They rode a fixed

  7. A Preliminary Study of Seismicity at Ceboruco, Volcano, Nayarit, Mexico

    Science.gov (United States)

    Sanchez, J. J.; Nunez-Cornu, F. J.; Suarez-Plascencia, C.; Trejo-Gomez, E.

    2007-12-01

    Ceboruco Volcano is located northwestern of Tepic-Zacoalco graben (Jalisco, Mexico). Its volcanic activity can be divided in four eruptive cycles differentiated by their volcano explosivity index (VEI) and chemical variations as well. As a result of andesitic effusive activity, during the first cycle the "paleo-Ceboruco" edifice was constructed. The end of this cycle is defined by a plinian eruption (VEI is estimated between 3 and 4) which occurred some 1020 years ago and formed the external caldera. During the second cycle an andesitic dome extruded in the interior of the caldera. The dome, called Dos Equis, collapsed and formed the internal caldera. The third cycle is represented by andesitic lava flows which partially cover the northern and south-southwestern part of the edifice. The last cycle is represented by historic andesitic lava flows located in the southwestern flank of the volcano. In February 2003 as part of an agreement with Nayarit Civil Defense a seismic station was installed in the SW flank of the volcano. The station is equipped with a Marslite (lennartz) digitizer with a 3DLe 1Hz. seismic sensor. Detection system is based on a STA/LTA recording algorithm. More than 2000 small earthquakes have been attributed to various local sources, and some of this earthquakes are possibly located beneath Ceboruco volcano. A preliminary classification separates high frequency and low frequency seismic events. The sources of high frequency earthquakes appear to be distributed as evidenced from waveforms variety and changing S-P arrivals separations. The low frequency seismic events also show varying signatures and some of them exhibit extended coda, including some monochromatic character.

  8. Tracking Study for Top-off Safety Validation at SSRL

    Energy Technology Data Exchange (ETDEWEB)

    Huang, X.; Bauer, J.; Corbett, J.; Dell' Orco, D.; Hettel, B.; Liu, J.; Rabedeau, T.; Safranek, J.; Schmerge, J.; Sebek, J.; Tanabe, J.; Terebilo, A.; Wang, L.

    2011-08-19

    A tracking study was performed at SSRL to identify necessary controls and to prove the safety of top-off operation from radiation hazard under such conditions. The safety rationale, tracking setup and the results are presented. Top-off operational mode has become a trend for existing and planned third-generation storage ring light sources for the many benefits such as increased average brightness, improved thermal stability and elimination of the interruption to user experiments due to traditional injection [1, 2]. Unlike the traditional decay mode injection which happens a few times a day and during which the photon beamline shutters are closed, top-off mode injection requires photon beamline shutters to remain open during injection and occurs much more frequently, from once every 5 seconds to once every 30 minutes. Therefore injection may be transparent to user experiments and the stored current variation can be significantly reduced. For a facility equipped with a full-energy injector, the biggest challenge to the implementation of the top-off mode may be the control of radiation hazard. Studies at ALS and SSRL [2, 3] have shown that a single injected electron pulse that enters the photon beamline and exits the radiation shield wall would cause unacceptable radiation doses on the experimental floor. For the protection of users and experimental equipment, it is hence a prerequisite for top-off operation to establish controls that absolutely prevent such occurrences. Similar to other facilities such as ALS and APS [2, 4], tracking simulations were conducted at SSRL to identify the control measures, define the specifications and prove the radiation safety. However, a different approach toward the proof of safety is taken at SSRL. In this paper we first describe the SSRL accelerator complex with emphasis on the aspects related to top-off in section 2. The general considerations and requirements for top-off are presented in section 3. Section 4 and 5 give a detailed

  9. The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study

    DEFF Research Database (Denmark)

    Esbjørn, Barbara Hoff; Breinholst, Sonja; Reinholdt-Dunne, Marie Louise;

    2011-01-01

    Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada.......Esbjørn, B. H., Breinholst, S., Reinholdt-Dunne, M. L., & Leth, I. (2011). The effect of parental involvement in CBT of anxious children: Preliminary results from a RCT study. Poster accepted for the Association for Behavioral and Cognitive Therapies, Toronto, Canada....

  10. Preliminary results from a field experiment on e-bike safety : speed choice and mental workload for middle-aged and elderly cyclists. Paper presented at the International Cycling Safety Conference 2013, Helmond, The Netherland, 20-21 November 2013.

    NARCIS (Netherlands)

    Twisk, D.A.M. Boele, M.J. Vlakveld, W.P. Christoph, M. Sikkema, R. Remij, R. & Schwab, A.L.

    2014-01-01

    To study the safety of e-bikes for the elderly, an experimental field study was conducted, using instrumented bicycles and comparing two age groups: older cyclists, n= 29, mean age = 70, SD = 4.2 and middle-aged cyclists, n = 29, mean age = 38, SD = 4.3. All were regular cyclists. They rode a fixed

  11. Preliminary results from a field experiment on e-bike safety : speed choice and mental workload for middle-aged and elderly cyclists. Paper presented at the International Cycling Safety Conference 2013, Helmond, The Netherland, 20-21 November 2013.

    NARCIS (Netherlands)

    Twisk, D.A.M. Boele, M.J. Vlakveld, W.P. Christoph, M. Sikkema, R. Remij, R. & Schwab, A.L.

    2014-01-01

    To study the safety of e-bikes for the elderly, an experimental field study was conducted, using instrumented bicycles and comparing two age groups: older cyclists, n= 29, mean age = 70, SD = 4.2 and middle-aged cyclists, n = 29, mean age = 38, SD = 4.3. All were regular cyclists. They rode a fixed

  12. Fire safety case study of a railway tunnel: Smoke evacuation

    Directory of Open Access Journals (Sweden)

    van Maele Karim

    2007-01-01

    Full Text Available When a fire occurs in a tunnel, it is of great importance to assure the safety of the occupants of the tunnel. This is achieved by creating smoke-free spaces in the tunnel through control of the smoke gases. In this paper, results are presented of a study concerning the fire safety in a real scale railway tunnel test case. Numerical simulations are performed in order to examine the possibility of natural ventilation of smoke in inclined tunnels. Several aspects are taken into account: the length of the simulated tunnel section, the slope of the tunnel and the possible effects of external wind at one portal of the tunnel. The Fire Dynamics Simulator of the National Institute of Standards and Technology, USA, is applied to perform the simulations. The simulations show that for the local behavior of the smoke during the early stages of the fire, the slope of the tunnel is of little importance. Secondly, the results show that external wind and/or pressure conditions have a large effect on the smoke gases inside the tunnel. Finally, some idea for the value of the critical ventilation velocity is given. The study also shows that computational fluid dynamics calculations are a valuable tool for large scale, real life complex fire cases. .

  13. Preliminary study to facilitate smart structure systems in bridge girders

    Science.gov (United States)

    Kirkpatrick, Thomas C.; Peterson, Danford O.; Rossi, Peter J.; Ray, Laura R.; Livingston, Richard A.

    1999-05-01

    Sensors are currently available and used to monitor structural performance and loads incurred by bridges already in service. However, there has been limited research concerning the stresses that steel bridge girders endure during transport from the manufacturer to the job site and during the installation process. This paper reports the measured stresses on steel bridge girders during transportation from Lancaster, PA to Hanover, NH and during construction of the Ledyard Bridge on the New Hampshire - Vermont border. Two different monitoring system were developed for this data acquisition in a mobile environment. The first, a fiber optic strain monitoring system, utilizing Bragg grating technology. The second utilized an electrical- resistive foil strain gage network, in conjunction with wireless telemetry equipment. Together, these two systems formed a smart structure system for monitoring bridge girders while confirming the accuracy of data gathered through redundancy. Result conclusively demonstrated for the first time, that stresses in beams during transportation are significant and approach the factor of safety margin in girder design.

  14. Battery energy storage: A preliminary assessment of national benefits (the Gateway Benefits Study)

    Energy Technology Data Exchange (ETDEWEB)

    Akhil, A. [Sandia National Labs., Albuquerque, NM (United States); Zaininger, H. [Zaininger Engineering Co., San Jose, CA (United States); Hurwitch, J.; Badin, J. [Energetics, Inc., Columbia, MD (United States)

    1993-12-01

    Preliminary estimates of national benefits from electric utility applications of battery energy storage through the year 2010 are presented along with a discussion of the particular applications studied. The estimates in this report were based on planning information reported to DOE by electric utilities across the United States. Future studies are planned to refine these estimates as more application-specific information becomes available.

  15. Enhancing Patient Safety Using Clinical Nursing Data: A Pilot Study.

    Science.gov (United States)

    Choi, Jeeyae; Choi, Jeungok E

    2016-01-01

    To enhance patient safety from falls, many hospital information systems have been implemented to collect clinical data from the bedside and have used the information to improve fall prevention care. However, most of them use administrative data not clinical nursing data. This necessitated the development of a web-based Nursing Practice and Research Information Management System (NPRIMS) that processes clinical nursing data to measure nurses' delivery of fall prevention care and its impact on patient outcomes. This pilot study developed computer algorithms based on a falls prevention protocol and programmed the prototype NPRIMS. It successfully measured the performance of nursing care delivered and its impact on patient outcomes using clinical nursing data from the study site. Results of the study revealed that NPRIMS has the potential to pinpoint components of nursing processes that are in need of improvement for preventing patient from falls.

  16. Construction Safety Assessment Framework for Developing Countries: A Case Study of Sri Lanka

    National Research Council Canada - National Science Library

    Kanchana Priyadarshani; Gayani Karunasena; Sajani Jayasuriya

    2013-01-01

    ... management in developing countries. [...]the aim of this study is to develop a method for measuring safety management on construction sites by identifying factors that affect construction safety performance...

  17. The childhood immunization schedule and safety: stakeholder concerns, scientific evidence, and future studies

    National Research Council Canada - National Science Library

    Board on Population Health and Public Health Practice; Institute of Medicine; Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule

    2013-01-01

    "The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies reviews scientific findings and stakeholders concerns related to the safety of the recommended childhood immunization schedule...

  18. Study on Analysis and Countermeasure of China's Legal System of Food Safety and Hygiene

    Directory of Open Access Journals (Sweden)

    Yongyong Zhu

    2013-12-01

    Full Text Available The aim of study is to solve the food safety problems existing in the real life, ensuring the food health safety, based on the “ Food Hygiene Law of the People's Republic of China” promulgated in 1995 by China, starting from the aspects such as production, marketing, regulatory to the integrate the standards of edible farm product quality safety standards, food hygiene standards, food quality standards and relevant food industry mandatory standards, establishing scientific and standardized food safety supervision system, food safety risk assessment system, food safety monitoring system and food safety standards, regulating the food inspection and food production and management responsibility to strengthen safeguard measures of citizens’ rights and interests to develop "The Food Safety Law of the People's Republic of China", to look forward to benefit the theoretical research and legislation improvement of the control law of China's food safety.

  19. [In vitro safety evaluation study of Angong Niuhuang Wan].

    Science.gov (United States)

    Wang, Xin-mei; Zhang, Su; Wang, Mei-bo; Xia, Jing; Li, Li-min; Wang, Ke; Ji, Shen

    2015-01-01

    To study a vitro extraction method to determine soluble mercury and mercury species in Angong Niuhuang Wan and investigate a vitro safety evaluation method, the best extraction scheme was determined after a great deal of conditioning experiments focusing on how the solvent, purification, duration of extraction and purification etc impact on mercury extraction. Soluble mercury was determined by inductively coupled plasma mass spectrometry and mercury species were determined by high performance liquid chromatography/inductively coupled plasma mass spectrometry. Result show that the best extraction method of soluble mercury and its species was ultrasonic extraction in artificial intestinal juice at 37 °C for 2 hours, letting it stand for 20 hours and taking the supermatant. The method was reproducible, which could simulate the human body environment to maximum extent. Methyl mercury, ethyl mercury and Hg2+ were not found in the extracts of Angong Niuhuang, although the content of soluble mercury was high. It Was concluded that the method could be applied to the vitro extraction and determination of soluble mercury and mercury species in Chinese traditional medicines containing cinnabar. Methyl mercury, ethyl mercury and Hg2+ could be taken as the targets of in vitro safety evaluation of Angong Niuhuang.

  20. Thermal Safety Study on TEGDN/NG/NC Gun Propellant

    Science.gov (United States)

    Yi, J. H.; Zhao, F. Q.; Hu, R. Z.; Xue, L.; Xu, S. Y.

    2010-10-01

    The self-accelerating decomposition temperature (TSADT), critical temperature of thermal explosion (Tb), adiabatic time to explosion (tTIad), 50% drop height of impact sensitivity (H50), critical temperature of hot spot initiation caused by impact (Tcr,hotspot), safety degree (Sd), critical thermal explosion ambient temperature (Tacr), and thermal explosion probability (PTE) of the gun propellant composed of triethyleneglycol dinitrate (TEGDN), nitroglycerin (NG), and nitrocellulose (NC) were studied. The results of thermal safety evaluation on the gun propellant were obtained: (1) T00 = 433.4 K, TSADT = Te0 = 441.1 K, Tb = Tbp0 = 468.4 K; (2) when Ek = 205.3 × 103 J mol -1 and Ak = 1020.62 s -1, tTIad = 48.3 s, H50 = 17.93 cm, Tcr, hotspot = 634.9 K; for a sphere sample, TS(T)max = 369.0K, Tacr = 364.2 K, Sd = 65.03%, PTE = 34.96%.

  1. [Safety evaluation of micronomicin. III. Teratogenicity studies in rats].

    Science.gov (United States)

    Hara, T; Nishikawa, S; Miyazaki, H; Ohguro, Y

    1983-01-01

    Micronomicin (MCR) is a new aminoglycoside antibiotic produced by Micromonospora sagamiensis var. nonreducans which was isolated from soil collected at Sagamihara by Nara et al. The purified antibiotic showed a close similarity to gentamicin C complex in physical and chemical properties. The antibacterial activity of MCR is broad-spectrum and almost equal to that of gentamicin C complex. MCR exhibits particularly high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc. and high activity against some Pseudomonas aeruginosa strains resistant to gentamicin C1a. Teratogenicity studies of MCR in rats were carried out by intravenous injection for safety evaluation (Dose; 25, 50 mg/kg and 75 mg/kg). The results of studies are as follows. 1. Fetal malformation attributable to MCR was not observed at any dose. 2. Suppression of maternal weight gain was observed at the dose levels of 50 mg/kg and over. 3. There was no adverse effect on new borns at any dose.

  2. Fusion Material Studies Relating to Safety in Russia in 2002

    Institute of Scientific and Technical Information of China (English)

    B. N. Kolbasov; M. I. Guseva; B. I. Khripunov; Y. V. Martynenko; P. V. Romanov; S. A. Lelekhov; S. A. Bartenev

    2004-01-01

    The paper is a summary of Russian material studies performed in frames of activities aiming at substantiation of safety of the International Thermonuclear Experimental Reactor (ITER) after 2001. Subthreshold sputtering of tungsten by 5eV deuterons was revealed at temperatures above 1150rm oC. Mechanism of globular films formation was further studied. Computations of tritium permeation into vacuum vessel coolant confirmed the acceptability of vacuum vessel cooling system for removal of the decay heat. The most dangerous accident with high-current arc in toroidal superconducting magnets able to burn out a bore up to 0.6 m in diameter in the cryostat vessel was determined. Radiochemical reprocessing of V-Cr-Ti alloy and its purification from activation products down to a contact dose rate of ~10muSv/h was developed.

  3. Preliminary Study on Safety Quality Changes of Protein and Oil during Production Process of Fish Meal%鱼粉生产过程中蛋白质、油脂安全质量变化的初步研究

    Institute of Scientific and Technical Information of China (English)

    彭侃; 张宝彤; 萧培珍; 罗其刚; 叶元土; 蔡春芳; 吴萍; 徐登辉; 林秀秀; 吴代武; 徐加英

    2015-01-01

    To investigate safety quality changes of protein and oil during production process of fish meal, this experiment was conducted to analyze quantitatively indices on oil oxidation [e.g. malonaldehyde (MDA) con-tent, peroxide value (POV), acid value (AV)] and decomposed protein products [e.g. contents of total vol-atile basic nitrogen ( TVBN) , histamine, putrescine, cadaverine, histidine, ornithine and lysine] . The sam-ples during production process of fish meal were collected in two adjacent fish meal factories ( factories A and B) which differ from cooking and drying parameters in Rongcheng city of Shandong province. The results showed as follows:1) during the history of manufacturing raw fish into fish meal, POV, AV,and the contents of TVBN, histamine, putrescine, cadaverine, histidine, ornithine and lysine of samples from factories A and B decreased significantly ( P<0.05) by at least 51.56% and 26.25%, respectively. 2) The contents of oil oxi-dation and protein decomposition products of samples from factories A and B decreased significantly by at least 70.74% and 26.5% during cooking and press process, respectively. 3) The contents of oil oxidation and pro-tein decomposition products of samples decreased significantly during drying process (P<0.05).The POV, AV, and the contents of MDA, TVBN, putrescine and cadaverine of samples from factory A, which uses 4-tank drying with the highest temperature of 83 ℃, decreased significantly ( P<0.05) by at least 4.58%. The POV, AV, and the contents of MDA, TVBN, histamine, putrescine and cadaverine of samples from factory B, which uses 3-tank drying with the highest temperature of 114 ℃, reduced significantly (P<0.05) by at least 4.73%. It is concluded that:1) the contents of oil oxidation and protein decomposition products of sam-ples are decreased significantly during the whole process which manufactures raw fish into fish meal ( P<0.05) . 2) It is cooking, press and drying process that can significantly decrease

  4. The Study on Safety of Scolopendrid Aqua-acupuncture

    Directory of Open Access Journals (Sweden)

    Lim Seung-il

    2004-02-01

    Full Text Available Objective : Recently scolopendrid aqua-acupuncture has been a good effect on pain control but it has not been known about clinical safety. The purpose of this study was to investigate acute toxicity of scolopendrid aqua-acupuncture. Method : In order to prove the clinical safety of scolopendrid aqua-acupuncture, We have observed a bacteriological examination and clinical pathology test after scolopendrid aqua-acupuncture treatment. Balb/c mice were injected intravenous with Scolopendrid aquaacupuncture treatment for and acute toxicity test. We analyzed physical reaction(side effectand clinical pathology test before and after Scolopendrid aqua-acupuncture treatment of mice and 20 patients suffering from pain, who admitted department of Acupunture and Moxibustion, College of Oriental Medicine, Won-Kwang University Kwangju hospital. Results : In the Blood agar plate and Nutrient agar plate, a bacteriological examination did not show a bacillus. In acute toxicity test, there was no mortality thus unable to attain the value. Examining the toxic response in the acute toxicity test, there was no sign of toxication. In acute toxic test, running biochemical serum test couldn't yield any differences between the control and experiment groups. In the 20 patients treated with Scolopendrid aqua-acupuncture, hematologic test did not show remarkable change. In the 20 patients treated with Scolopendrid aqua-acupuncture, Liver function test(AST, ALT, ALP showed a slight decrease on the contrary, and abnormal rate showed a decrease of 5.0% compared with previous study. Reanl function test(BUN, Cr and abnormal rate showed a decrease of 5.0% compared with previous study. In the 20 patients treated with Scolopendrid aqua-acupuncture, Electrolyte were normal range before and after treatment. In the Urine analysis of 20 patients, Leukocyte, Protein, Glucose, Keton, Bilirubin, U-bilinogen were not detected before and after Scolopendrid aqua-acupuncture treatment, and

  5. Assessment of Safety Condition in One of the Teaching Hospitals in Kermanshah (2015: A Case Study

    Directory of Open Access Journals (Sweden)

    Masod Ghanbari Kakavand

    2016-09-01

    Full Text Available Background & Aims of the Study: Many working conditions-related stress factors that can produce injuries and illnesses are important in hospital environments. So, the health and safety of nurses and patients from workplace-induced injuries and illnesses is important. In this study, we have assessed the safety condition of one of the teaching hospitals in Kermanshah (2015. Materials and Methods: This descriptive and cross-sectional study was conducted in one of the teaching hospital of Kermanshah University of medical sciences. For this aim a checklist was prepared based on the Occupational Safety and Health Administration's standards and Part 3 of the manual of National Building Regulations. These checklists comprised (The final checklist had 239 questions of 9 dimensions various sections of safety including; fire safety, building safety, electrical safety, emergency exit routes safety, heating and cooling equipment safety, operating room and laundry room and salty home safety. Eventually, using SPSS 16 and descriptive statistics, data were analyzed. Results: According to the results of this study, 66.6% of the units had poor safety and 33.4% of them were moderately safe. As well as, only ICU and CCU unit, heating and cooling equipment and operational room showed moderate compliance with safety requirements and other sections were poorly complied. Conclusion: The results of this study showed that safety conditions of hospital were not at favorable level. These poor safety statues can jeopardize patients and hospital personnel. Thus some interventions such as improvement of working conditions, compliance with safety acts and implementation of health, safety and environmental management system would be necessary.

  6. A Preliminary Study of the Western Zhou Building Foundations at Yuntang in Fufeng, Shaanxi

    Institute of Scientific and Technical Information of China (English)

    徐良高; 王巍; 丁晓雷

    2003-01-01

    From autumn 1999 through the year 2000, Zhouyuan Archaeological Team excavated a set of Western Zhou building foundations, which was well preserved and uniquely designed. It is significantly valuable for the research on the ritual system of the Western Zhou Dynasty. We here by try to make a preliminary study on its structure and function with reference of historical literature.

  7. Feasibility and preliminary effectiveness of preoperative therapeutic exercise in patients with cancer: a pragmatic study.

    NARCIS (Netherlands)

    Timmerman, H.; Groot, J.F. de; Hulzebos, H.J.; Knikker, R. de; Kerkkamp, H.E.M.; Meeteren, N.L. van

    2011-01-01

    The aim of this pilot study is to determine the feasibility and preliminary effectiveness of an individually designed preoperative therapeutic exercise program (PreTEP), in patients recently diagnosed with cancer and awaiting elective surgery. The purpose is to improve their physical fitness levels

  8. Preliminary results of a feasibility study for a hard x-ray Kirkpatrick-Baez telescope

    DEFF Research Database (Denmark)

    Joensen, Karsten D.; Gorenstein, Paul; Wood, James L.

    1994-01-01

    the preliminary results of a feasibility study of a multifocus Kirkpatrick-Baez telescope. We conclude that high quality multilayers can be performed on relevant thin large flat substrate with adequate uniformity, and that existing deposition chambers can produce the multilayers at a rate of 0.42 m2 per day, so...

  9. Robot assisted navigated drilling for percutaneous pedicle screw placement: A preliminary animal study

    Directory of Open Access Journals (Sweden)

    Hongwei Wang

    2015-01-01

    Conclusions: The preliminary study supports the view that computer assisted pedicle screw fixation using spinal robot is feasible and the robot can decrease the intraoperative fluoroscopy time during the minimally invasive pedicle screw fixation surgery. As spine robotic surgery is still in its infancy, further research in this field is worthwhile especially the accuracy of spine robot system should be improved.

  10. Feasibility of pulse oximetry in the initial prehospital management of victims of drowning : A preliminary study

    NARCIS (Netherlands)

    Montenij, Leonard J.; de Vries, Wiebe; Schwarte, Lothar; Bierens, Joost J. L. M.

    2011-01-01

    Aim: Immediate delivery of oxygen is the most important treatment for victims of drowning at the rescue site. Monitoring oxygen saturation with pulse oximetry is potentially useful, but its use may be limited by poor peripheral perfusion due to hypothermia. This preliminary study explores the feasib

  11. Correlates of Cigarette Smoking among Male Chinese College Students in China--A Preliminary Study

    Science.gov (United States)

    Li, Kaigang; Kay, Noy S.

    2009-01-01

    The main purpose of this preliminary study was to examine the association between four constructs of the Health Belief Model (HBM) (i.e. perceived severity of smoking-related health problems, perceived susceptibility to smoking-health related problems, perceived barriers to non-smoking and perceived benefits of non-smoking) and cigarette smoking …

  12. Zero-gravity cloud physics laboratory: Experiment program definition and preliminary laboratory concept studies

    Science.gov (United States)

    Eaton, L. R.; Greco, E. V.

    1973-01-01

    The experiment program definition and preliminary laboratory concept studies on the zero G cloud physics laboratory are reported. This program involves the definition and development of an atmospheric cloud physics laboratory and the selection and delineations of a set of candidate experiments that must utilize the unique environment of zero gravity or near zero gravity.

  13. Feasibility and preliminary effectiveness of preoperative therapeutic exercise in patients with cancer: A pragmatic study

    NARCIS (Netherlands)

    Timmerman, H.; Groot, J.F. de; Hulzebos, H.J.; Knikker, R. de; Kerkkamp, H.E.M.; Meeteren, N.L.U. van

    2011-01-01

    The aim of this pilot study is to determine the feasibility and preliminary effectiveness of an individually designed preoperative therapeutic exercise program (PreTEP), in patients recently diagnosed with cancer and awaiting elective surgery. The purpose is to improve their physical fitness levels

  14. Occupational Therapy in the Context of Head Start: A Preliminary Survey Study

    Science.gov (United States)

    Bowyer, Patricia; Moore, Cary C.; Thom, Carly

    2016-01-01

    This preliminary, descriptive study yields information on the utilization of occupational therapy services within Head Start programs. Participants completed an Internet-based survey of 25 questions pertaining to the understanding, scope, and utilization of occupational therapy services. Surveys were completed by 35 respondents nationwide. A total…

  15. A Quantitative Approach to Investigating Spanish HL Speakers' Characteristics and Motivation: A Preliminary Study

    Science.gov (United States)

    Yanguas, Inigo

    2010-01-01

    The present preliminary study empirically investigated Spanish heritage language (HL) speakers in Spanish for native speakers (SNS) college courses. It focused on their attitudes and motivation to improve their HL and on their varying linguistic competences in that language. A well-established second language acquisition (SLA) motivational model…

  16. A preliminary study on electromyographic analysis of the paraspinal musculature in idiopathic scoliosis

    NARCIS (Netherlands)

    Cheung, J.; Halbertsma, J.P.; Veldhuizen, A.G.; Sluiter, W.J.; Maurits, N.M.; Cool, J.C.; van Horn, J.R.

    2005-01-01

    The paraspinal muscles have been implicated as a major causative factor in the progression of idiopathic scoliosis. Therefore, the objectives of this preliminary study were to measure the electromyographic activity (EMG) of the paraspinal muscles to determine its relationship to progression of the s

  17. Early Language and Literacy Development among Young English Language Learners: Preliminary Insights from a Longitudinal Study

    Science.gov (United States)

    Roessingh, Hetty; Elgie, Susan

    2009-01-01

    This article reports on the preliminary findings of a two-staged empirical study aimed at gaining insights into the variables salient in the early language and literacy development of young English language learners (ELL). Increasingly, young ELL, whether foreign-born or Canadian-born, arrive at school with little developed English-language…

  18. Nd:YAG laser treatment of herpes and aphthous ulcers: a preliminary study

    Science.gov (United States)

    Parkins, Frederick M.; O'Toole, Thomas J.; Yancey, John M.

    2000-06-01

    Previously herpes labialis and recurrent aphthous ulcers have not been successfully treated. A preliminary study with a pulsed Nd:YAG laser evaluated the results with a protocol of four minute non-contact exposures for both types of lesions. Most patients experienced relief of symptoms. The progress of herpes lesion was halted and aphthous lesions became desensitized.

  19. School Library Support of Health Education in China: A Preliminary Study

    Science.gov (United States)

    Liu, Geoffrey Z.; Zhang, Wuhong

    2008-01-01

    This preliminary study investigates the current situation of school library support of K-12 health education in China. A survey of 42 school librarians and 115 K-12 teachers from selected schools was conducted to find out their views about school library's role in school health education and their current practice of library use in health…

  20. Preliminary design and parametric study of 1400 m partially earth-anchored cable-stayed bridge

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The preliminary design and parametric study of 1400 m partially earth-anchored cable-stayed bridge are described. Static per-formance of this new type of bridge is discussed. Compared with fully self-anchored cable-stayed bridge, its advantages in fin-ished state are summarized. Based on numerical calculation, effects of several structural parameters on static performance are presented.

  1. Preliminary Study on the Determination of ~(235)U and ~(239)Pu Using Delayed Neutron Counting Method

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The preliminary study on the fast measurements of 235U and 239Pu in samples containing 235U, 239Pu and 235U-239Pu mixture using delayed neutron counting method is introduced. All samples were irradiated for 30 s using the 30 kW Miniature Neutron

  2. Comparison of Brain Activity during Drawing and Clay Sculpting: A Preliminary qEEG Study

    Science.gov (United States)

    Kruk, Kerry A.; Aravich, Paul F.; Deaver, Sarah P.; deBeus, Roger

    2014-01-01

    A preliminary experimental study examined brain wave frequency patterns of female participants (N = 14) engaged in two different art making conditions: clay sculpting and drawing. After controlling for nonspecific effects of movement, quantitative electroencephalographic (qEEG) recordings were made of the bilateral medial frontal cortex and…

  3. Preliminary Study of m(b) Bias at Selected Soviet Seismic Stations.

    Science.gov (United States)

    1986-03-21

    8217-R66 395 PRELIMINARY STUDY OF M(B) BIRS AT SELECTED SOVIET 1/1 SEISMIC STRTIONS(U) SCIENCE APPLICATIONS INTERNATIONAL CORP ARLINGTON VR A S RYRLL...earthquakes in each source region was not given in the ,.t 1980 paper, but in the earlier work it ranged from 35 events for Asia and the Mediter - ranean to

  4. CNG 加气站初步设计及安全风险评价%Preliminary Design and Safety Risk Assessment of a CNG Filling Station

    Institute of Scientific and Technical Information of China (English)

    唐倩

    2015-01-01

    CNG(压缩天然气)作为当今汽车能源的重要组成部分,凭借其污染小、经济性好、成本低等优势得到迅速推广,CNG 汽车市场占有率越来越大,CNG 加气站的需求量也日益增加。根据《汽车加油加气站设计与施工规范》,对某 CNG 加气站进行初步设计,并结合国内外 CNG 加气站安全风险评价技术,采取科学、系统、完善的方针,对该 CNG 加气站进行安全风险评价。%CNG (compressed natural gas) as an important part of today's automotive energy, has many advantages, such as low pollution, good economy, low cost and so on, so it has gained rapid promotion, and CNG vehicle market share is growing, the demand of CNG filling station is increasing. In this paper, based on the " Specification for design and construction of automobile gasoline and gas filling station" ,preliminary design of a CNG filling station was carried out, the CNG gas station security risk was assessed by safety risk assessment techniques.

  5. Key aspects in managing safety when working with multiple contractors: A case study

    NARCIS (Netherlands)

    Drupsteen, L.; Rasmussen, H.B.; Ustailieva, E.; Kampen, J. van

    2015-01-01

    Working with multiple contractors in a shared workplace can introduce and increase safety risks due to complexity. The aim of this study was to explore how safety issues are recognized in a specific case and to identify whether clients and contractors perceive problems similarly. The safety issues

  6. Key aspects in managing safety when working with multiple contractors: A case study

    NARCIS (Netherlands)

    Drupsteen, L.; Rasmussen, H.B.; Ustailieva, E.; Kampen, J. van

    2015-01-01

    Working with multiple contractors in a shared workplace can introduce and increase safety risks due to complexity. The aim of this study was to explore how safety issues are recognized in a specific case and to identify whether clients and contractors perceive problems similarly. The safety issues a

  7. 77 FR 19414 - Pipeline Safety: Public Comment on Leak and Valve Studies Mandated by the Pipeline Safety...

    Science.gov (United States)

    2012-03-30

    ... Studies Mandated by the Pipeline Safety, Regulatory Certainty, and Job Creation Act of 2011 AGENCY..., Regulatory Certainty, and Job Creation Act of 2011 has called for several commissioned studies and reports to... controls, automation, supervisory control and data acquisition systems, and valve spacing. Also to...

  8. Study on Safety Management of Food Traceability Based on Food Supply Chain

    Directory of Open Access Journals (Sweden)

    Boyi Xiang

    2015-06-01

    Full Text Available With the frequent occurrence of food safety problems in recent years, it is urgent to solve safety management problem of food traceability. In this study, with an overview of the food supply chain, it explores the significant meaning of safety management of food traceability as well as the traceability types of supply chains, discussing the construction measures and procedures of safety management of food traceability as well as the technical designing demand on food traceability system.

  9. PRELIMINARY STUDY TO PRIMARY EDUCATION FACILITIES (A Comparison Study between Indonesia and Developed Countries

    Directory of Open Access Journals (Sweden)

    Lucy Yosita

    2006-01-01

    Full Text Available This writing is a preliminary study to condition of primary education facilities in Indonesia, and then comparing these with theories as well as various relevant cases aimed to know the problem more obviously. Basically, there is difference between primary education facilities in Indonesia with those in developed countries. Meanwhile on the other hand, the condition as well as the completion of education facility is actually as the main factor contributes to address the purpose of learning process. If building design, interior and also site plan were dynamic in form, space, colour and tools, those would be probably more stimulate activity and influence into the growth of students. However, lastly, it is still required further analysis, as an example analysis to student's behaviour in spaces of learning environment, more detail and within enough time, not only at indoor but also at outdoor.

  10. Attitude is everything? The impact of workload, safety climate, and safety tools on medical errors: a study of intensive care units.

    Science.gov (United States)

    Steyrer, Johannes; Schiffinger, Michael; Huber, Clemens; Valentin, Andreas; Strunk, Guido

    2013-01-01

    Hospitals face an increasing pressure toward efficiency and cost reduction while ensuring patient safety. This warrants a closer examination of the trade-off between production and protection posited in the literature for a high-risk hospital setting (intensive care). On the basis of extant literature and concepts on both safety management and organizational/safety culture, this study investigates to which extent production pressure (i.e., increased staff workload and capacity utilization) and safety culture (consisting of safety climate among staff and safety tools implemented by management) influence the occurrence of medical errors and if/how safety climate and safety tools interact. A prospective, observational, 48-hour cross-sectional study was conducted in 57 intensive care units. The dependent variable is the incidence of errors affecting those 378 patients treated throughout the entire observation period. Capacity utilization and workload were measured by indicators such as unit occupancy, nurse-to-patient/physician-to-patient ratios, levels of care, or NEMS scores. The safety tools considered include Critical Incidence Reporting Systems, audits, training, mission statements, SOPs/checklists, and the use of barcodes. Safety climate was assessed using a psychometrically validated four-dimensional questionnaire.Linear regression was employed to identify the effects of the predictor variables on error rate as well as interaction effects between safety tools and safety climate. Higher workload has a detrimental effect on safety, whereas safety climate-unlike the examined safety tools-has a virtually equal opposite effect. Correlations between safety tools and safety climate as well as their interaction effects on error rate are mostly nonsignificant. Increased workload and capacity utilization increase the occurrence of medical error, an effect that can be offset by a positive safety climate but not by formally implemented safety procedures and policies.

  11. Young Females' Attention towards Road Safety Images: An ERP Study of the Revised Reinforcement Sensitivity Theory.

    Science.gov (United States)

    Kaye, Sherrie-Anne; White, Melanie J; Lewis, Ioni

    2017-08-24

    This study examined whether reward and punishment sensitivities, as conceptualised by Gray and McNaughton's revised Reinforcement Sensitivity Theory (RST), influenced young female drivers' attention towards a series of positive and negative anti-speeding advertisement images. Young females' increasing crash risk is associated with their engagement in risky behaviours which, in turn, has been associated with a stronger Behavioural Approach System (BAS; sensitive to rewards). It was predicted that individuals with a stronger BAS would elicit larger N100 and N200 mean amplitudes (reflecting greater attention) towards the positive images. Similar associations were predicted in relation to the Fight-Flight-Freeze System (FFFS; sensitive to punishments) for negative images. Twenty-four female drivers (17-25 years; final N = 16) completed Corr-Cooper's (2013) RST-Personality Questionnaire, prior to undergoing an Event-Related Potential computerised visual task (i.e., oddball paradigm) which comprised positive, negative, and neutral images as targets against checkerboard image distractors. Contrary to expectations, individuals with a stronger BAS (Reward Reactivity and Impulsivity) demonstrated significantly larger N200 mean amplitudes on presentation of the negative images than those with weaker a BAS, at the Cz electrode site. No other significant RST effects were found. These findings provide some preliminary objective support for the use of negative emotion-based road safety advertisements for young females. Further, this study provides support for using psychophysiological measures to enhance understanding of traffic injury persuasion.

  12. A Sensitivity Study for an Evaluation of Input Parameters Effect on a Preliminary Probabilistic Tsunami Hazard Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rhee, Hyun-Me; Kim, Min Kyu; Choi, In-Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Sheen, Dong-Hoon [Chonnam National University, Gwangju (Korea, Republic of)

    2014-10-15

    The tsunami hazard analysis has been based on the seismic hazard analysis. The seismic hazard analysis has been performed by using the deterministic method and the probabilistic method. To consider the uncertainties in hazard analysis, the probabilistic method has been regarded as attractive approach. The various parameters and their weight are considered by using the logic tree approach in the probabilistic method. The uncertainties of parameters should be suggested by analyzing the sensitivity because the various parameters are used in the hazard analysis. To apply the probabilistic tsunami hazard analysis, the preliminary study for the Ulchin NPP site had been performed. The information on the fault sources which was published by the Atomic Energy Society of Japan (AESJ) had been used in the preliminary study. The tsunami propagation was simulated by using the TSUNAMI{sub 1}.0 which was developed by Japan Nuclear Energy Safety Organization (JNES). The wave parameters have been estimated from the result of tsunami simulation. In this study, the sensitivity analysis for the fault sources which were selected in the previous studies has been performed. To analyze the effect of the parameters, the sensitivity analysis for the E3 fault source which was published by AESJ was performed. The effect of the recurrence interval, the potential maximum magnitude, and the beta were suggested by the sensitivity analysis results. Level of annual exceedance probability has been affected by the recurrence interval.. Wave heights have been influenced by the potential maximum magnitude and the beta. In the future, the sensitivity analysis for the all fault sources in the western part of Japan which were published AESJ would be performed.

  13. Preliminary Evaluation of Clinical and Angiographic Outcomes with Biodegradable Polymer Coated Sirolimus-Eluting Stent in De Novo Coronary Artery Disease: Results of the MANIPAL-FLEX Study

    Directory of Open Access Journals (Sweden)

    Ranjan Shetty

    2016-01-01

    Full Text Available Objective. The objective of the MANIPAL-FLEX study was to evaluate the feasibility, preliminary safety, and efficacy of the Supraflex sirolimus-eluting stent (SES implantation, in de novo coronary artery disease, using clinical and quantitative coronary angiography (QCA follow-ups. Methods. This was a prospective, nonrandomized, multicenter, single-arm study that enrolled 189 patients with de novo coronary artery disease who were treated with the Supraflex SES. Of 189 patients enrolled, the first 61 consecutive patients who consented to a 9-month follow-up evaluation by QCA, irrespective of presence of symptoms, were to be followed up with angiography at 9 months. The primary endpoint of the study was target lesion failure (TLF, including cardiac death, myocardial infarction, and target lesion revascularization during 12-month follow-up after the index procedure. Results. The mean age of the study population was 58±11 years, with 51.3% (97/189 of hypertensive patients. Total of 66 lesions, analyzed by offline QCA, showed good scaffolding of the target vessel with in-stent late lumen loss at 9 months of 0.18±0.23 mm. The observed TLF at 30-day, 6-month, and 12-month follow-up were 2 (1.1%, 6 (3.2%, and 10 (5.3%, respectively. Conclusion. This study provides preliminary evidence for the feasibility, safety, and efficacy of the Supraflex sirolimus-eluting stent.

  14. Preliminary study of the decay heat removal strategy for the gas demonstrator allegro

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, Gusztáv, E-mail: gusztav.mayer@energia.mta.hu [Hungarian Academy of Sciences, Centre for Energy Research, P.O. Box 49, H-1525 Budapest (Hungary); Bentivoglio, Fabrice, E-mail: fabrice.bentivoglio@cea.fr [CEA/DEN/DM2S/STMF/LMES, F-38054, Grenoble (France)

    2015-05-15

    Highlights: • Improved decay heat removal strategy was adapted for the 75 MW ALLEGRO MOX core. • New nitrogen injection strategy was proposed for the DEC LOCA transients. • Preliminary CATHARE study shows that most of the investigated transients fulfill criteria. • Further improvements and optimizations are needed for nitrogen injection. - Abstract: The helium cooled Gas Fast Reactor (GFR) is one of the six reactor concepts selected in the frame of the Generation IV International Forum. Since no gas cooled fast reactor has ever been built, a medium power demonstrator reactor – named ALLEGRO – is necessary on the road towards the 2400 MWth GFR power reactor. The French Commissariat à l’Energie Atomique (CEA) completed a wide range of studies during the early stage of development of ALLEGRO, and later the ALLEGRO reactor concept was developed in several European Union projects in parallel with the GFR2400. The 75 MW thermal power ALLEGRO is currently developed in the frame of the European ALLIANCE project. As a result of the collaboration between CEA and the Hungarian Academy of Sciences Centre for Energy Research (MTA EK) new improvements were done in the safety approach of ALLEGRO. A complete Decay Heat Removal (DHR) strategy was devised, relying on the primary circuits as a first way to remove decay heat using pony-motors to drive the primary blowers, and on the secondary and tertiary circuits being able to work in forced or natural circulation. Three identical dedicated loops circulating in forced convection are used as a second way to remove decay heat, and these loops can circulate in natural convection for pressurized transients, providing a third way to remove decay heat in case of accidents when the primary circuit is still under pressure. The possibility to use nitrogen to enhance both forced and natural circulation is discussed. This DHR strategy is supported by a wide range of accident transient simulations performed using the CATHARE2 code

  15. PHARMACOGNOSTICAL AND PRELIMINARY PHYTOCHEMICAL STUDIES OF CASSIA SOPHERA LINN.

    Directory of Open Access Journals (Sweden)

    Chavan Chetan

    2011-02-01

    Full Text Available Pharmacognostical parameters for the all three parts of Cassia sophera L were studied with the aim of drawing the pharmacopoeial standards for this species. Macroscopical and microscopical characters, physicochemical constants, extractive values of dry powder and its reaction after treatment with chemical reagents were studied. The determination of these characters will aid future investigators in their Pharmacological analyses of this species.

  16. Personality Study of Hawaii Japanese Nonagenarians: Preliminary Findings. Technical Report.

    Science.gov (United States)

    Izutsu, Satoru; Rose, Charles L.

    As part of a larger study of the demographics, family, household, health, diet, activity, functioning, and mental ability of older Japanese people living in Hawaii which will be compared to similar studies conducted in Japan, personality data were obtained from 101 noninstitutionalized Japanese with an average age of 92 years, residing in Hawaii.…

  17. Preliminary studies on some aspects of Kikuyu food habits

    NARCIS (Netherlands)

    Hoorweg, J.C.; Niemeijer, R.

    1980-01-01

    Description of a research project. The studies cover general aspects of Kikuyu food habits such as foods presently in use, the classification of foods and food preferences for children. The emphasises is on the methods employed in these studies which can also be used elsewhere to obtain information

  18. Modeling and Testing of EVs - Preliminary Study and Laboratory Development

    DEFF Research Database (Denmark)

    Yang, Guang-Ya; Marra, Francesco; Nielsen, Arne Hejde;

    2010-01-01

    Electric vehicles (EVs) are expected to play a key role in the future energy management system to stabilize both supply and consumption with the presence of high penetration of renewable generation. A reasonably accurate model of battery is a key element for the study of EVs behavior and the grid...... tests, followed by the suggestions towards a feasible battery model for further studies....

  19. Study of the Service Reliability of Machines Based on Safety

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    From the point of safety being the basic requirement of machine operation, equivalent failure number, which is employed to replace the actual statistical failure number, is introduced. Calculating theory of service reliability indexes of machines based on safety is developed. The method proposed in this paper can reflect the damage degree of failure.

  20. A study on the methodology of probabilistic safety assessment for KALIMER

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kwan Seong; Kwon, Young Min; Lee, Yong Bum; Jeong, Hae Yong; Yang, Joon Eon; Ha, Kyu Suk; Hahn, Do Hee [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-03-01

    Existing Probabilistic Safety Assessment(PSA) is a method for Light Water Reactor or Pressurized Heavy Water Reactor. Because KALIMER is different from these reactor, the new methodology of PSA need to be developed. In this paper, the PSA of Power Reactor Inherently Safety Module(PRISM) is analyzed, and Initiating Event such as Experiential Assessment, Logical Assessment and Failure Mode Effect Analysis(FMEA) is reviewed. Also, Pipe Damage Frequency Method is suggested for KALIMER. And the Reliability Physical method of Passive System, which is a chief safety system of KALIMER, is reviewed and its applicability is investigated. Finally, for the Preliminary PSA of KALIMER, Intermediate Heat Transfer System is analyzed. 23 refs., 10 figs., 13 tabs. (Author)

  1. The study on safety facility criteria for radioactive waste repository

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. H.; Choi, M. H.; Han, S. H. and others [Dongbang Electron Industry Corporation, (Korea, Republic of)

    1992-12-15

    The radioactive waste repository are necessary to install the engineered safety systems to secure the safety for operation of the repository in the event of fire and earthquake. Since the development of safety facility criteria requires a thorough understanding about the characteristics of the engineered safety systems, we should investigate by means of literature survey and visit SKB. In particular, definition, composition of the systems, functional requirement of the systems, engineered safety systems of foreign countries, system design, operation and maintenance requirement should be investigated : fire protection system, ventilation system, drainage system, I and C system, electric system, radiation monitoring system. This proposed criteria consist of purpose, scope of application, ventilation system, fire protection system, drainage system, electric system and this proposed criteria can be applied as a basic reference for the final criteria.

  2. Preliminary toxicological study of Sylgard 184 curing agent

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.M.; London, J.E.; Drake, G.A.; Thomas, R.G.

    1978-06-01

    The acute oral LD/sub 50//sup 30/ values for mice and rats receiving Sylgard 184 curing agent were greater than 5 g/kg. According to classical guidelines, the compound would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the compound to be mildly irritating. Eye irritation studies, also in the rabbit, showed that Sylgard 184 curing agent was a mild but transitory irritant. The sensitization study in guinea pigs did not show the resin to be deleterious.

  3. Preliminary toxicological study of Sylgard 184 encapsulating resin

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.M.; Drake, G.A.; London, J.E.; Thomas, R.G.

    1978-06-01

    The acute oral LD/sub 50//sup 30/ values for Sylgard 184 encapsulating resin in mice and rats were greater than 5 g/kg. According to classical guidelines, the compound would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated this material to be mildly irritating. Eye irritation studies, also in the rabbit, showed that Sylgard 184 encapsulating resin was a mild but transitory irritant. The sensitization study in guinea pigs did not show the resin to be deleterious in this regard.

  4. Impact of individual resilience and safety climate on safety performance and psychological stress of construction workers: A case study of the Ontario construction industry.

    Science.gov (United States)

    Chen, Yuting; McCabe, Brenda; Hyatt, Douglas

    2017-06-01

    The construction industry has hit a plateau in terms of safety performance. Safety climate is regarded as a leading indicator of safety performance; however, relatively little safety climate research has been done in the Canadian construction industry. Safety climate may be geographically sensitive, thus it is necessary to examine how the construct of safety climate is defined and used to improve safety performance in different regions. On the other hand, more and more attention has been paid to job related stress in the construction industry. Previous research proposed that individual resilience may be associated with a better safety performance and may help employees manage stress. Unfortunately, few empirical research studies have examined this hypothesis. This paper aims to examine the role of safety climate and individual resilience in safety performance and job stress in the Canadian construction industry. The research was based on 837 surveys collected in Ontario between June 2015 and June 2016. Structural equation modeling (SEM) techniques were used to explore the impact of individual resilience and safety climate on physical safety outcomes and on psychological stress among construction workers. The results show that safety climate not only affected construction workers' safety performance but also indirectly affected their psychological stress. In addition, it was found that individual resilience had a direct negative impact on psychological stress but had no impact on physical safety outcomes. These findings highlight the roles of both organizational and individual factors in individual safety performance and in psychological well-being. Construction organizations need to not only monitor employees' safety performance, but also to assess their employees' psychological well-being. Promoting a positive safety climate together with developing training programs focusing on improving employees' psychological health - especially post-trauma psychological

  5. Ostracism among Gifted Adolescents: A Preliminary Study in Turkey

    Directory of Open Access Journals (Sweden)

    Uzeyir Ogurlu

    2015-11-01

    Full Text Available Ostracism has an influence on psychological and social functioning. The aim of this study is to examine ostracism among gifted students, with regard to gender and grade levels. Also, the relationship between ostracism and intelligence level was investigated. The study was conducted in a gifted education center, with 94 gifted students who were attending middle school (grades 5-8. The Ostracism Experience Scale for Adolescents and Wechsler Intelligence Scale for Children – Revised Form were employed as data collection tools. According to the findings obtained from the study, it is concluded that ostracism did not differ in terms of gender among gifted students. Besides, being socially excluded may be higher in 8th grades than 6th and 7th grades. Also in the study, a positive correlation was found between intelligence level and ostracism. Discussion and suggestions were also provided based on the results.

  6. A preliminary study on limnological stock assessment, productivity ...

    African Journals Online (AJOL)

    use

    productivity and potential fish yield of Omi Dam,. Nigeria ... the world over through growing populations, intensification of .... The concentration of organic substances in water and ... The mean dissolved oxygen recorded in this study is 5.12.

  7. Features and Functions of Journals: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Bambang Yudi Cahyono

    1997-01-01

    Full Text Available Abstract: This study is intended to describe the features and functions of journals written by EFL learners. The features described include the contents and organization of the journals. The functions examined in this study include sense of purpose and sense of audience in writing. The subjects of the study were students of the first semester who took English intensive course at the English Department of IKIP MALANG. The results of content analysis indicate that journals that the students write contain various themes. Analysis on paragraph organization indicates that paragraphs in the journals generally show adequate development. This study also shows that the student journals reflect sense of purpose and sense of audience in writing.

  8. A PRELIMINARY STUDY OF CERVICOVAGINAL PEROXIDASES AS INDICATORS FOR OVULATION

    Institute of Scientific and Technical Information of China (English)

    XIANGHong-Fa; HANZi-Yan; LIANGZang-Guang; XIESu-Xiang

    1989-01-01

    There were many studies using cervicovaginal peroxidases to predict ovulation. Some resuits suggested that cervieovaginal peroxidases are reliable indicators for ovulation; but others did not. The present study was designed to determine whether the change patterns of ccrvicovaginal guaiacul peroxidase activity in fertile period of Chinese women can also be served as a basis for development of a technique to predict ovulation time in natural family planning.

  9. Anaerobic culture by Total Air Barrier: A preliminary study

    Directory of Open Access Journals (Sweden)

    Soma Sarkar

    2010-03-01

    Full Text Available BackgroundFor study with obligate anaerobes, inoculated platescontaining suitable reduced media need handling andincubation under strict anaerobic condition. Instead ofensuring a confined oxygen free chamber for placing seededplates, same purpose may be achieved by creating total airbarrier to the surface.MethodUpper moist surface of freshly prepared anaerobic media inPetri plates were intimately covered with very thintransparent bacteriological inert sterile polyester sheets.Stock culture of Bacteroides fragilis, ATCC 23745 andClostridium sporogenes, ATCC 11437 were grown in cookedmeat broth and then sub-cultured on respective plates, afterlifting the cover sheets. Sheets were again covered andincubated at 37oC ordinary incubator. To performantimicrobial susceptibility test, similarly covered seededplates with well inoculums were inverted en-block afterstripping sides with the help of a spatula. Now antibiotic diskswere placed on upper bare surfaces. After short pre-diffusion,plates were incubated keeping inoculated surface below.Same study was performed by conventional method usingGaspak.ResultsGood growths were noted in both sets of the study;however discrete colonies appeared more flat in nature intest set. Almost identical zones of inhibition were noted inboth sets of sensitivity study. Seven days old growths incovered blood agar plates were found viable when subculturedin cooked meat broths.ConclusionIsolation, identification and susceptibility study for mostclinically important obligate anaerobes may be performedby simple barrier method after appropriatestandardization.

  10. [Omeprazole: a new treatment for paranasal sinus polyps in Widal syndrome. Preliminary study].

    Science.gov (United States)

    Serra, J; Piñas, J; Arnaiz, J A; Quesada, P; Naches, S; Lorente, J; Carne, X

    1998-05-01

    A preliminary report is made of the potential therapeutic effect of omeprazol in reducing nasosinusal polyps. This study is based on the empirical observation of nasal airflow improvement in patients suffering from nasosinusal polyposis after administering omeprazol. Different phases of the study suggested that patients with Widal's syndrome benefited the most. Based on the results of this study, we have undertaken a randomized, parallel, double-blind, placebo-controlled clinical trial.

  11. Assessing interpersonal aspects of schizoid personality disorder: preliminary validation studies.

    Science.gov (United States)

    Kosson, David S; Blackburn, Ronald; Byrnes, Katherine A; Park, Sohee; Logan, Caroline; Donnelly, John P

    2008-03-01

    In 2 studies, we examined the reliability and validity of an interpersonal measure of schizoid personality disorder (SZPD) based on nonverbal behaviors and interpersonal interactions occurring during interviews. A total of 556 male jail inmates in the United States participated in Study 1; 175 mentally disordered offenders in maximum security hospitals in the United Kingdom participated in Study 2. Across both samples, scores on the Interpersonal Measure of Schizoid Personality Disorder (IM-SZ) exhibited adequate reliability and patterns of correlations with other measures consistent with expectations. The scale displayed patterns of relatively specific correlations with interview and self-report measures of SZPD. In addition, the IM-SZ correlated in an expected manner with features of psychopathy and antisocial personality and with independent ratings of interpersonal behavior. We address implications for assessment of personality disorder.

  12. Preliminary toxicological study of Sylgard 184 encapsulating resin: curing agent

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.M.; Drake, G.A.; London, J.E.; Thomas, R.G.

    1978-06-01

    The acute oral LD/sub 50//sup 30/ values for Sylgard 184 (100 parts encapsulating resin plus 10 parts curing agent) were greater than 5 g/kg in rats and mice. According to classical guidelines, the mixture would be considered slightly toxic or practically nontoxic in both species. Skin application studies in the rabbit demonstrated the mixture to be mildly irritating. Eye irritation tests, also in the rabbit, showed the Sylgard 184 mixture to be a mild but transitory irritant. The sensitization study in the guinea pig demonstrated the mixture to be a very mild sensitizer in two of six animals.

  13. Preliminary studies for the LHCb vertex detector vacuum system

    CERN Document Server

    Doets, M; Van Bakel, N; Van den Brand, J F J; van den Brand, Jo

    2000-01-01

    We lay down some general considerations which will serve as a starting point for design studies of a realistic LHCb vertex detector vacuum system. Based on these considerations, we propose a design strategy and identify issues to be further studied. In particular we try to outline some boundary conditions imposed by LHC and LHCb on the vacuum system. We discuss two possibilities for the LHCb vertex detector vacuum system. The preferred strategy uses a differentially pumped vacuum system with the silicon detectors separated from the beam line vacuum. Some estimations on static vacuum pressures and gas flows are presented.

  14. Contractors’ Attitude towards Enhancing Safety Performance: Case Study on Construction Firms in Penang

    Directory of Open Access Journals (Sweden)

    Ulang N. Md

    2014-01-01

    Full Text Available A qualitative study was conducted to investigate the contractors’ attitude towards enhancing the safety performance in construction site. Despite the fact that there are many safety initiatives established by the government, the rates of accidents are still in a critically high condition. Thus the purpose of this research is to study the contractors’ attitude towards enhancing the implementation of safety management system in construction site in order to increase the safety awareness of construction practitioners in construction site and improve the safety condition of construction sites. This study is conducted through oral interviews with the construction practitioners, and visual inspection of construction sites. The attitudes of contractors are evaluated from 3 aspects: Contractors’ efforts in implement and enforce the safety rules, Contractors efforts in overcoming the rate of accidents, and Reasons given by the contractors for not implement safety law.

  15. The effect of chemotherapy on rat brain PET: preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Su; Kim, Il Han; Yu, A Ram; Park, Ji Ae; Woo, Sang Keun; Kim, Jong Guk; Cheon, Gi Jeong; Kim, Byeong Il; Choi, Chang Woon; Lim, Sang Moo; Kim, Hee Joung; Kim, Kyeong Min [Korea Institute Radiological and Medical Science, Seoul (Korea, Republic of)

    2010-10-15

    Chemotherapy was widely used for the therapy of cancer patients. When chemotherapy was performed, transient cognitive memory problem was occurred. This cognitive problem in brain was called as chemobrain. In this study, we have developed rat model for chemobrain. Cerebral glucose metabolism after chemotherapy was assessed using animal PET and voxel based statistical analysis method

  16. Preliminary studies of inhibitions in Aspergillus flavus with extracts of ...

    African Journals Online (AJOL)

    Administrator

    of lichens on the growth of lower Phycomycetes and. Neurospora ... have indicated the possible use of plant as well as lichen extracts in the control of plant diseases. The extraction, ... under light microscope (*400 objective) for the emergence of germ tube. .... artificial fungicide develop, this study has shown that extracts of ...

  17. Psychiatric morbidity in oral lichen planus: A preliminary study

    Directory of Open Access Journals (Sweden)

    Abhishek Ranjan Pati

    2014-01-01

    Full Text Available Objective: To study the clinical types and association of psychological factors in patients with Oral Lichen Planus (OLP. Materials and Methods: An analytical age- and sex-matched study involved 30 patients with oral lichen planus (group 1 and 30 control subjects (group 2. We applied the following psychometric tests to both groups: General Health Questionnaire (GHQ and Hospital Anxiety and Depression Scale (HADS. Results: The patients with OLP were found to exhibit statistically significant higher anxiety, insomnia, and social dysfunction with the tests that were used (GHQ 24 and HADS than the control group (P > 0.05. The study group likewise exhibited greater depression and somatic symptoms. The mean total of the GHQ and HAD scores were found to be higher in the study group than in the controls (P > 0.05. Among the various types of OLP, patients with the erosive type had higher mean scores for anxiety and insomnia, social dysfunction and depression. Conclusion: In most patients psychiatric morbidity was strongly associated with OLP, which could support its role in the etiopathogenesis of the disease. The higher scores of the General Health Questionnaire and Hospital Anxiety and Depression Scale gave an insight into the hypothesis that psychological factors are associated with the causation of OLP.

  18. Buffalo Harbor Study. Preliminary Feasibility Report. Volume I. Main Report.

    Science.gov (United States)

    1983-04-01

    the Buffalo Ornithological Society . Although these groups are not planning agencies, they represent an important trend in land use planning. The groups...Buffalo Historical Society , 1902. Wilson , Carroll L. Coal: Bridge to the Future, Report of the World Coal Study. Cambridge: Ballinger Publishing Company... Wilson , 1980) PLANNING CONSTRAINTS Federal policy on multiobjective planning, derived from both legislative and executive authorities, establishes and

  19. Burnout among Special Education Administrators: A Preliminary Study

    Science.gov (United States)

    Carter, Susan J.

    2011-01-01

    Research on the extent of stress and burnout among special education administrators is not as well developed as research on the extent of stress and burnout among teachers. This study utilized the Maslach Burnout Inventory to determine levels of stress and burnout among administrators of special education. Results indicated administrators of…

  20. Preliminary study Malaa. Final report; Foerstudie Malaa. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Factors of importance for a possible localization of a deep nuclear waste repository at Malaa in northern Sweden are mapped in this study. The geologic structures in the area have been reviewed, mostly from already existing knowledge. Existing infrastructure and necessary improvements are discussed, as well as land use and environment, employment and other social effects. 47 refs, 41 figs, 8 tabs.

  1. Violence Prevention in Middle School: A Preliminary Study

    Science.gov (United States)

    KIllam, Wendy K.; Roland, Catherine B.; Weber, Bill

    2014-01-01

    Violence in schools continues reflecting violence within society. There is a growing need for violence prevention programs within the schools that provide students with the skills needed to cope with interpersonal and relationship is-sues effectively. This study was conducted at a middle school and there were 345 middle school students (6th to 8th…

  2. Preliminary studies in the genus Entoloma in Tasmania - I

    OpenAIRE

    Gates, Genevieve M.; Noordeloos, Machiel

    2007-01-01

    This paper describes 33 new species of Entoloma from wet and dry forests in Tasmania, Australia, based on 8 years of intensive collecting, description and study of the Entoloma mycota. As such it is a precursor to a monographic treatment of the Entolomataceae of Tasmania, to be published in the next few years.

  3. Preliminary studies in the genus Entoloma in Tasmania - I

    NARCIS (Netherlands)

    Gates, Genevieve M.; Noordeloos, Machiel

    2007-01-01

    This paper describes 33 new species of Entoloma from wet and dry forests in Tasmania, Australia, based on 8 years of intensive collecting, description and study of the Entoloma mycota. As such it is a precursor to a monographic treatment of the Entolomataceae of Tasmania, to be published in the next

  4. Study and Preliminary Analysis of Test of Aerosol Migration Mechanism

    Institute of Scientific and Technical Information of China (English)

    CHEN; Lin-lin; SUN; Xue-ting; WEI; Yan-song

    2015-01-01

    TAMM(test of aerosol migration mechanism)is one of the important aspects of Studies on Migration Mechanism of the Source Term under Severe Accident,which is a significant research of the National Large Advanced PWR Research Program.The main task researches the

  5. ENDOPHYTIC FUNGI FROM JATROPHA CURCUS: A PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    Santosh Kumar Singh

    2013-04-01

    Full Text Available Fungal endophytes are ubiquitously reported from the living tissues of healthy plant parts from every host studied so far. These microbes attributed significantly in upraising the caliber of the host to counteract against the different stresses and herbivores, and also some times to improve the host fitness. This study presenting here the endophytic mycoflora of Jatropha curcus, which remain less explored. A total of eighteen species of fungi were isolated from leaf, stem, and roots of Jatropha curcus. The root was heavily colonized by the genera like Alternaria, Cladosporium, and Aspergillus spp. The leaf tissues however showed somewhat greater diversity of endophytic colonization. Drechslera, Curvularia, Bipolaris, Alternaria, and Aspergillus sp. were dominant in to the leaf tissues with strong presence of an unidentified genus. The species richness as well as frequency of colonization of endophytic fungi was more pronounced in the leaf tissues rather than the root and stem. This study reaffirms the fact that endophytes are host and tissues specific. In this regard, the endophytic fungi received in this study, may represent a unique source of one or more of the interesting and useful bioactive compounds similar to those of vinca alkaloid group.

  6. Radioisotope study of Eustachian tube. A preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    De Rossi, G.; Campioni, P.; Vaccaro, A.

    1988-08-01

    Radioisotope studies of Eustachian tube are suggested in the preoperative phase of tympanoplasty, in order to assess tubal drainage and secretion. The use of gamma camera fitted to a computer allowed the AA, to calculate some semi-quantitative parameters for an exact assessment of the radioactivity transit from the tympanic cass up to the pharyngeal cavity, throughout the Eustachian tube.

  7. A Preliminary Study on Bucket Foundations under Transient Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo; Nielsen, Søren Kjær;

    2013-01-01

    This study aims at investigating the behaviour of monopod bucket foundations through a physical model. The foundation is installed in dense water-saturated sand and is subjected to lateral load applied at different rates. The different loading rates allow for exploring the patterns of response of...

  8. preliminary multidomain modelling and simulation study of a ...

    African Journals Online (AJOL)

    user

    Renewable energy sources have gained much attention due to the recent energy crisis and ... system for the most energy capture for this case study to be a rotor speed of 5.5rad/s at a height of 10m. .... Thesis, Faculty of California Polytechnic.

  9. Functional Communication Training in Rett Syndrome: A Preliminary Study

    Science.gov (United States)

    Byiers, Breanne J.; Dimian, Adele; Symons, Frank J.

    2014-01-01

    Rett syndrome (RTT) is associated with a range of serious neurodevelopmental consequences including severe communicative impairments. Currently, no evidence-based communication interventions exist for the population (Sigafoos et al., 2009). The purpose of the current study was to examine the effectiveness of functional assessment (FA) and…

  10. From Numbers to Action: A Preliminary Study of Retention.

    Science.gov (United States)

    Greenlee, Shelia Parker; Greenlee, Harry

    This study examined retention at Christopher Newport University (CNU) in Newport News, Virginia, focusing on the demographic characteristics of those students who left the university as well as the reasons why they left. A total of 159 students who had attended CNU during the 1994-95 academic year but who did not re-enroll in the fall of 1995 were…

  11. Water Safety Plan for drinking water risk management: the case study of Mortara (Pavia, Italy

    Directory of Open Access Journals (Sweden)

    Sabrina Sorlini

    2017-08-01

    Full Text Available The Water Safety Plan (WSP approach is an iterative method focused on analyzing the risks of water contamination in a drinking water supply system, from catchment to consumer, in order to protect human health. This approach is aimed at identifying and drastically reducing water contamination in the entire drinking water system, through the identification and mitigation or, if possible, elimination of all factors that may cause a chemical, physical, microbiological and radiological risk for water. This study developed a proposal of WSP for the drinking water supply system (DWSS of Mortara, Italy, in order to understand which are the preliminary evaluation aspects to be considered in the elaboration of a WSP. The DWSS of Mortara (a town of 15,500 inhabitants, located in northern Italy consists of three drinking water treatment plants (DWTPs, considering the following main contaminants: arsenic, iron, manganese and ammonia. Potential hazardous events and associated hazards were identified in each part of the water supply system. The risk assessment was carried out following the semi quantitative approach. The WSP proposal for Mortara was very useful not only as a risk mitigation approach, but also as a cost-effective tool for water suppliers. Furthermore, this approach will reduce public health risk, ensure a better compliance of water quality parameters with regulatory requirements, increase confidence of consumers and municipal authorities, and improve resource management due to intervention planning. Further, some new control measures are proposed by the WSP team within this work.

  12. Robotic nipple-sparing mastectomy for the treatment of breast cancer: Feasibility and safety study.

    Science.gov (United States)

    Toesca, Antonio; Peradze, Nickolas; Manconi, Andrea; Galimberti, Viviana; Intra, Mattia; Colleoni, Marco; Bonanni, Bernardo; Curigliano, Giuseppe; Rietjens, Mario; Viale, Giuseppe; Sacchini, Virgilio; Veronesi, Paolo

    2017-02-01

    We previously devised and reported on an innovative surgical technique of robotic nipple-sparing mastectomy and immediate robotic breast reconstruction. Here we describe the outcome of the first 29 such consecutive procedures performed on breast cancer patients to assess feasibility, reproducibility and safety. The following morbidity factors were tested: operation time, conversion rate to open technique, length of hospitalization, registration of complications for 1 year postoperatively and their characterization as either minor, major, or multiple, depending on clinical severity and treatment required. The total duration of the final robotic surgeries of our series was around 3 h, showing a very rapid learning curve. The conversion rate due to technical problems was 2 of the 29 procedures (6,9%). No major complications, including hematoma, seroma, skin or nipple-areola injury or necrosis or infection were observed for any case. Two patients had a small degree of blistering from internal electrocautery in the breast skin flap, both of which resolved in one week without any specific therapy. No systemic complications were observed. The low conversion rate to open surgery, the rapid learning curve and the low rate of post-operative complications observed in this preliminary series lead us to endorse a prospective study aimed at evaluating patient satisfaction. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Safety profiling of pioglitazone and telmisartan combination by sub-chronic toxicity study in rat.

    Science.gov (United States)

    Sengupta, Pinaki; Das, Arindam; Ibrahim, Fuzianna; Mandal, Uttam Kumar; Chatterjee, Bappaditya; Mahmood, Syed; Das, Sreemoy Kanti; Kifayatullah, Muhammad

    2016-11-01

    It has been reported that the major cause of mortality in diabetes is cardiovascular diseases and contribution of hypertension is significant in this context. Pioglitazone, a thiazolidinedione class of therapeutic agent is used to treat type 2 diabetes mellitus. Telmisartan, an angiotensin receptor blocker antihypertensive has been reported to have beneficial effect if co-administered with pioglitazone for the management of diabetes complications. The present research work aims to evaluate the safety/toxicity profile of this combination in rat model. The investigation was carried out after co-administering the drugs to the rats for 28 days at three dose levels of 50, 100 and 150 mg/kg covering low to high dose ranges. Various hematological and biochemical parameters were studied in addition to the histopathology of the major organs in order to evaluate the toxicity profile of the combination. Absence of mortality and histopathological changes as well as unaltered hematological and biochemical parameters was observed. This preliminary investigation concludes that the combination of pioglitazone and telmisartan can primarily be stated as safe in animals, even at the dose level which is several folds higher than the intended human dose. Thus, this combination can be explored in future to develop a rational therapy regimen to treat hypertensive diabetic patients.

  14. Status of the EU test blanket systems safety studies

    Energy Technology Data Exchange (ETDEWEB)

    Panayotov, Dobromir, E-mail: dobromir.panayotov@f4e.europa.eu; Poitevin, Yves; Ricapito, Italo; Zmitko, Milan

    2015-10-15

    Highlights: • TBS safety demonstration files. • Safety functions and related design features – detailed TBS components classifications. • Nuclear analyses, radiation shielding and protection. • TBS radiological waste management strategy and categorization. • Selection and definition of reference accidents scenarios and accidents analyses. - Abstract: The European joint undertaking for ITER and the development of fusion energy (‘Fusion for Energy’ – F4E) provides the European contributions to the ITER international fusion energy research project. Among others it includes also the development, design, technological demonstration and implementation of the European test blanket systems (TBS) in ITER. Currently two EU TBS designs are in the phase of conceptual design – helium-cooled lithium-lead (HCLL) and helium-cooled pebble-bed (HCPB). Safety demonstration is an important part of the work devoted to the achievement of the next key project milestone the conceptual design review. The paper reveals the details of the work on EU TBS safety performed in the last couple of years: update of the TBS safety demonstration files; safety functions and related design features; detailed TBS components classifications; nuclear analyses, radiation shielding and protection; TBS radiological waste management strategy and categorization; selection and definition of reference accidents scenarios, and accidents analyses. Finally the authors share the information on on-going and planned future EU TBS safety activities.

  15. Dissociation and fantasy proneness in psychiatric patients: a preliminary study.

    Science.gov (United States)

    Merckelbach, Harald; à Campo, Joost; Hardy, Solange; Giesbrecht, Timo

    2005-01-01

    Nonclinical studies found that dissociative experiences are intimately linked to a trait known as fantasy proneness. We examined the links among dissociative symptoms, fantasy proneness, and impulsivity in psychiatric outpatients. Our sample consisted of 22 patients with schizophrenia, 20 patients with a diagnosis of borderline personality disorder, and 19 patients with a major depressive disorder. For the whole sample, levels of dissociation were found to be related to fantasy proneness and impulsivity. There were group differences in dissociative symptoms, with patients with borderline personality disorder reporting more such symptoms than patients with either schizophrenia or major depressive disorder. The overlap between dissociation and fantasy proneness may have important ramifications for studies addressing comorbid phenomena of dissociative symptoms.

  16. Preliminary study of radioactive waste disposal in the vadose zone

    Energy Technology Data Exchange (ETDEWEB)

    1978-09-01

    To investigate the characteristics of the vadose zone with respect to radioactive waste disposal, the mechanics of unsaturated flow in arid regions and the geohydrology of four areas with a deep water table were studied. The studies indicated that (1) arid sites with a water table deeper than 200 m can be found in at least three distinct geologic settings in the western United States, (2) the physics of unsaturated flow in soils and rock with interstitial porosity at low water contents, particularly under thermal gradients, is not yet completely understood, and (3) under certain conditions unsaturated flow can be so slow that analytic modeling of an unflawed repository is unnecessary to prove effective containment.

  17. Cetaceans and fisheries in Kenya coastal waters: a preliminary study.

    OpenAIRE

    Omondi, E.

    1995-01-01

    Of all marine resources characteristic of the Kenyan coast, marine mammals are least studied singly or in association with other resources. In this paper, available records on cetacean catches by district between 1978-1991 inclusive were used to assess the status and trend of their fishery, distribution, and interaction with sharks, clupeids and tuna landings. Spartial and temporal variations in takes were evident. The Mombasa district led in total catch (62.2 tons) while the Tana River distr...

  18. Protocol Development and Preliminary Toxicity Study of CBRN Nanomaterials

    Science.gov (United States)

    2013-12-05

    Schlager, and S.M. Hussain. 2009. Cyrstal Structure Mediates Mode of Cell Death in TiO2. Nanotoxicity. J Nanopart Res. 11(6):1361-1374. Cao, C.J., K...Mouse Keratinocytes. J Nanopart Res. 11:15-24. Toxicology Study No. 87-XE-0EJ5-11 (FY12 Continuation) B-1 Appendix B - Figures 10 - 1 . 0 0 10 - 0 . 7 5

  19. V. PRELIMINARY STUDY ON ISOZYMES OF SHOREA JAVANICA

    Directory of Open Access Journals (Sweden)

    U. JUNIARTI and M. I. J. UMBOH

    1987-01-01

    Full Text Available The detection of genetic variability in natural or man-made populations/ plantations is useful in both basic and applied biology. In addition to the various facets of studies on Shorea javanica already initiated by Torquebiau (1984 and alongside with his recommendations on focus for future research, a study on the genetic aspects of the species should be given important considerations. As the trees are tapped for resin, an important forest product, the genetic basis of the production as well as the range of variation in amount of resin production among t he trees must be known. Coupled with this is a thorough investigation on the differences in pest resistance/susceptability among the trees and their genetic basis. While the assumption (Torquebiau 1984 that trees in natural forest areas are-rarely attacked by diseases because of mycorrhizal fungi is interesting, its confirmation is necessary. If this is true, problems would arise when plants are introduced into a new plantation site as experienced by the Forest Research Institute (Ardikoesuma 1954. Thus, we need to look for pest resistant plants i.e. those that can remain healthy even in the absence of mycorrhizae. The above studies on possible genetic variation could give vital information for development of forest plantations of the species and for breeding and tree improvement strategies. By knowing the extent of genetic variation in natural population or in plantations one could be guided to maintain or increase the genetic base in these areas. Biochemical characters such as isozyme banding patterns have been useful in several areas of plant biology, population genetics, evolution and breeding. Isozymes are detected by starch gel electrophoresis and when their genetic control is established, they could be genetic markers in analyzing variation in morphological or physiological characters. The present study is an attempt to detect the isozymes in leaves, seeds and cotyledons of Shorea

  20. A preliminary metagenomic study of puer tea during pile fermentation.

    Science.gov (United States)

    Lyu, Changyong; Chen, Chaoyin; Ge, Feng; Liu, Diqiu; Zhao, Shenglan; Chen, Dan

    2013-10-01

    Up to now, there has been no report on the taxonomic and functional analysis of the microbial community in fermenting puer tea by pyrosequencing. In this study, metagenomic pyrosequencing was first used in fermenting puer tea to delineate a relatively comprehensive overview of the microbial taxonomy while also preliminarily characterising the functional ontologies of microbial genes present in puer tea pile fermentation. A total of 251 738 pyrosequencing reads (9197 contigs and 145 402 singletons) were generated by pyrosequencing. Taxonomic analysis revealed three dominant bacterial phyla, Actinobacteria (30.08%), Proteobacteria (24.47%) and Firmicutes (20.23%), and one dominant eukaryotic phylum, Ascomycota (15.21%) [corrected]. A total of 58 664 hits were categorised into 28 functional subsystems based on the SEED database. Moreover, two categories, 'metabolism of terpenoids and polyketides' and 'biosynthesis of other secondary metabolites', were selectively analysed and 69 enzyme genes were presented in 16 pathways. The dominant microbes of puer tea fermentation were bacteria in the present study, and yeasts rather than moulds accounted for the overwhelming majority of Eukaryota. The analysis of functional genes and metabolic pathways will be helpful for further study of the mechanism of puer tea fermentation at molecular level. © 2013 Society of Chemical Industry.

  1. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    Maryam Kazemi

    2013-12-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan.  Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  2. Preliminary Study of Mental Retardation in Rovira (Tolima, Colombia

    Directory of Open Access Journals (Sweden)

    Luis Gustavo Celis

    2008-07-01

    Full Text Available limitationsin performance, significant deficiencyin intelligence and adaptative behavior, causingclinical and social disability. Most patients withmental retardation in Colombia do not receiveclinical genetics evaluation. The aims of thepresent study are to evaluate and characterizea group of patients with mental retardationfrom the population of Rovira. The presentstudy included twenty five patients with mentalretardation from Rovira (Tolima whichwere studied by clinical examination, metabolicscreening (ferric chloride, nitrosonaphtol,silver nitroprusiate, dinitrophenylhydrazineand benedict and cytogenetics (G-Bandingkariotype. Pesticide detection was perfomedby random sampling of water and tomatoes intwenty different places of water distribution,the center of the town and crop fields. A familywith three affected sibs (two females, onemale with mental retardation was identified,suggesting a genetic component. Metabolicscreening was negative and karyotypes werenormal. The analyses performed for organophosphateswere positive in 100% of the samples.Carbamates were positive in 60% of thewater source and 100% of tomato samples. Allthe samples tested were negative for organochlorides.Further studies as molecular fragile-X test, will be performed.

  3. Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

    Directory of Open Access Journals (Sweden)

    1Maryam Kazemi

    2013-11-01

    Full Text Available Each year, over a billion Muslims fast worldwide during the month of Ramadan. Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.

  4. Motor Empathy in Individuals With Psychopathic Traits: A Preliminary Study.

    Science.gov (United States)

    Khvatskaya, Yelena; Lenzenweger, Mark F

    2016-10-01

    The present laboratory study examined motor empathy in male and female individuals, who were either high or low on psychopathic traits, drawn from a nonclinical university population. Past findings suggest that psychopathic individuals are impaired in affective empathy, but findings on impairments in cognitive empathy are mixed. Research on motor empathy in psychopathy is scarce. The authors hypothesized that individuals high on psychopathic traits would have deficient motor empathy (similar to affective empathy) related to valenced emotion stimuli because of the automatic nature of motor empathy. Potential participants completed the Psychopathic Personality Inventory-Revised (PPI-R). Participants were chosen for the study on the basis of their PPI-R scores. All participants viewed photographic images drawn from a well-established set of stimuli (the International Affective Picture System) and were video recorded while doing so. Intensity for eight emotions (anger, contempt, disgust, fear, sad, joy, surprise, and neutral) in participants' facial expressions was measured objectively using an automated program, the Computer Expression Recognition Toolbox. Individuals high on psychopathic traits as compared with low PPI-R scorers displayed significantly less emotional congruence when viewing negative images. The study results suggest that deficits in motor empathy related to psychopathic trait levels are relatively restricted to negative emotions.

  5. Preliminary studies on cryopreservation of snakehead (Channa striata) embryos.

    Science.gov (United States)

    Mohd Sharifuddin, M; Siti Azizah, M N

    2014-08-01

    This paper reports the findings of the ongoing studies on cryopreservation of the snakehead, Channa striata embryos. The specific objective of this study was to collect data on the sensitivity of C. striata embryo hatching rate to low temperatures at two different developmental stages in the presence of four different cryoprotectants. Embryos at morula and heartbeat stages were selected and incubated in 1M dimethyl sulfoxide (Me2SO), 1M ethylene glycol (EG), 1M methanol (MeOH) and 0.1M sucrose solutions at different temperatures for a period of time. Embryos were kept at 24 °C (control), 15 °C, 4 °C and -2 °C for 5 min, 1h and 3h. Following these treatments, the embryos were then transferred into a 24 °C water bath until hatch to evaluate the hatching rate. The results showed that there was a significant decrease of hatching rate in both developmental stages following exposure to 4 °C and -2 °C at 1h and 3h exposure in each treatment. Heartbeat stage was more tolerant against chilling at -2 °C for 3h exposure in Me2SO followed by MeOH, sucrose and EG. Further studies will be conducted to find the best method to preserve embryos for long term storage.

  6. A Preliminary Study of 3D Printing on Rock Mechanics

    Science.gov (United States)

    Jiang, Chao; Zhao, Gao-Feng

    2015-05-01

    3D printing is an innovative manufacturing technology that enables the printing of objects through the accumulation of successive layers. This study explores the potential application of this 3D printing technology for rock mechanics. Polylactic acid (PLA) was used as the printing material, and the specimens were constructed with a "3D Touch" printer that employs fused deposition modelling (FDM) technology. Unconfined compressive strength (UCS) tests and direct tensile strength (DTS) tests were performed to determine the Young's modulus ( E) and Poisson's ratio ( υ) for these specimens. The experimental results revealed that the PLA specimens exhibited elastic to brittle behaviour in the DTS tests and exhibited elastic to plastic behaviour in the UCS tests. The influence of structural changes in the mechanical response of the printed specimen was investigated; the results indicated that the mechanical response is highly influenced by the input structures, e.g., granular structure, and lattice structure. Unfortunately, our study has demonstrated that the FDM 3D printing with PLA is unsuitable for the direct simulation of rock. However, the ability for 3D printing on manufactured rock remains appealing for researchers of rock mechanics. Additional studies should focus on the development of an appropriate substitution for the printing material (brittle and stiff) and modification of the printing technology (to print 3D grains with arbitrary shapes).

  7. Mukha Mo: A Preliminary Study on Filipino Facial Expressions

    Directory of Open Access Journals (Sweden)

    Richard Jonathan O. Taduran

    2012-12-01

    Full Text Available This study tested the universality hypothesis on facial expression judgment by applying cross-cultural agreement tests on Filipinos. The Facial Action Coding System constructed by Ekman and Friesen (1976 was used as basis for creating stimuli photos that 101 college student observers were madeto identify. Contextualization for each emotion was also solicited from subjects to provide qualitative bases for their judgments. The results showed that for five of the six emotions studied, excepting fear, the majority of the observers judged the expressions as predicted. The judgment of happiness supplied the strongest evidence for universality, having the highest correctness rate and inter-observer agreement. There was also high agreement among observersand between Filipinos and other cultures about the most intense and second most intense emotion signaled by each stimulus for these five emotions. Difficulty with the recognition of fear, as well as its common association with the emotion of sadness, has been found. Such findings shall serve as baseline data for the study of facial expressions in the Philippines.

  8. Effects of Omeprazole on Iron Absorption: Preliminary Study

    Directory of Open Access Journals (Sweden)

    Mahmut Yaşar Çeliker

    2013-09-01

    Full Text Available Objective: Increasing numbers of pediatric and adult patients are being treated with proton pump inhibitors (PPIs. PPIs are known to inhibit gastric acid secretion. Nonheme iron requires gastric acid for conversion to the ferrous form for absorption. Ninety percent of dietary and 100% of oral iron therapy is in the nonheme form. To the best of our knowledge, the effect of PPIs on iron absorption has not been studied in humans. Our study assessed the relationship between omeprazole therapy and iron absorption in healthy subjects. Materials and Methods: We recruited 9 healthy volunteers between June 2010 and March 2011. Subjects with chronic illness, anemia, or use of PPI therapy were excluded. Serum iron concentrations were measured 1, 2, and 3 h after the ingestion of iron (control group. The measurements were repeated on a subsequent visit after 4 daily oral administrations of omeprazole at a dose of 40 mg (treatment group. Results: One female and 8 male volunteers were enrolled in the study with a mean age of 33 years. There was no statistical difference detected between baseline, 1-h, 2-h, and 3-h iron levels between control and treatment groups. Conclusion: Administration of omeprazole for a short duration does not affect absorption of orally administered iron in healthy individuals.

  9. Histological Subgroups in Classic Kaposi Sarcoma: A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Nilüfer Onak Kandemir

    2010-06-01

    Full Text Available Background and Design: Kaposi sarcomas (KS are vascular tumors with a low malignant potential which include overlapping infectious, immunologic, and neoplastic processes. Recently, many histological subtypes have been defined. Material and Method: In the present study, 151 cutaneous classic KS lesions in 56 patients were retrospectively evaluated with regard to histological subtypes. Determination of the subtypes was based on the predominant histopathological component in the lesion. We examined changes in epidermis and dermis along with intratumoral inflammatory response characteristics in the lesions. By defining histopathological variants of the cases, differences regarding subtypes were investigated. Results: Cases that bear the ordinary characteristics of KS and those that can not be classified otherwise, comprised 82..8% of the study group. Twenty-six cases showed consistency with the subtypes outlined in the literature in terms of their histopathological properties. The most common histological subtype was the lymphangiectatic variant in 7.3% of the cases. Bullous (2.6%, lymphangioma like (2.6%, intravascular (2%, and pyogenic granuloma like (2% variants were less common. The most uncommon histological subtype was micronodular (0.6% type. Lymphangiectatic, bullous, intravascular, and pyogenic granuloma like variants were frequently observed in the nodular stage of KSs. Lympangioma like changes were seen to be present in the early KS lesions. Lymphangiectatic type was oftenly associated with bullous component, whereas pyogenic granuloma like type demonstrated superficial ulceration and intense inflammatory response. Lymphangioma like and intravascular types exhibited a characteristic appearance, while other variants were accompanied by components belonging to different subtypes. Conclusion: In KS, histopathological subtypes can develop as a result of different pathological processes. The next stage of the current study, which is one of the

  10. A preliminary study of dengue infection in Brunei.

    Science.gov (United States)

    Osman, Osmali; Fong, Mun Yik; Devi, Shamala

    2007-07-01

    The purpose of this study was to examine the extent of dengue infection in Brunei and to determine the predominant serotype circulating in the country. The study generated useful epidemiological data on dengue infection in Brunei. A total of 271 samples from patients suspected of having dengue infections were selected and analyzed. All patients were seen in clinics and hospitals in Brunei. The samples were collected from April 2005 to April 2006 and transported to the WHO Collaborating Centre for Arbovirus Reference and Research, University of Malaya, Malaysia. The following tests were used to achieve the objectives: in-house IgM-capture enzyme-linked immunosorbent assay, virus isolation in mosquito albopictus cell line (C6/36), and viral RNA detection and serotyping by reverse transcriptase-polymerase chain reaction (RT-PCR). The results show that 45 people were positive for dengue-specific IgM (27 males and 18 females), while RT-PCR detected dengue viral RNA in 12 patients, 3 identified as DEN-1 and 9 as DEN-2. Dengue virus was isolated from 6 patients using the C6/36 cell line; 3 were DEN-2 isolates and 3 were DEN-1 isolates. These data show that dengue virus is circulating in Brunei and the predominant infecting serotype for that period was DEN-2 followed by DEN-1. This study is the first to report the detection and isolation of dengue virus from Brunei using RT-PCR and culture in the C6/36 albopictus mosquito cell line.

  11. A preliminary study on spatial unmasking of virtual separated sources

    Institute of Scientific and Technical Information of China (English)

    XIE ZhiWen; JIN Jing

    2008-01-01

    An experimental method with headphone virtual reproduction is proposed and a series of experiments to study forward masking effect when the masker and the masked signal are spatially separated in azimuth are conducted. Then, the masking thresholds are compared with those when the masker and the masked signal source are at the same place. The results show that, although both the thresholds of 0°and±30° sound images increase with the sound pressure level (SPL) of the masker, spatial unmasking may be really observed. The maximum unmasking is as large as 15 dB. This spatial unmasking effect is mainly attributed to better-ear con-tribution.

  12. A preliminary study on spatial unmasking of virtual separated sources

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    An experimental method with headphone virtual reproduction is proposed and a series of experiments to study forward masking effect when the masker and the masked signal are spatially separated in azimuth are conducted. Then, the masking thresholds are compared with those when the masker and the masked signal source are at the same place. The results show that, although both the thresholds of 0° and ±30° sound images increase with the sound pressure level (SPL) of the masker, spatial unmasking may be really observed. The maximum unmasking is as large as 15 dB. This spatial unmasking effect is mainly attributed to better-ear contribution.

  13. ARSENIC DEGRADATION BY Pseudomonas aeruginosa FOR WATER BIOREMEDIATION. PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    Esther E. Pellizzari

    2015-03-01

    Full Text Available The aim of this study was to investigate the arsenic resistance in pure cultivations of Pseudomonas aeruginosa isolated from Presidencia Roque Sáenz Peña groundwater (Chaco province, and evaluate the possibility of its use to remove arsenic from groundwater. Strains were immobilized in natural stone and cultivated in salts broth and 1 mgAs/L. The arsenic resistance and biofilm formation were observed, obtaining interaction between cells, rock and arsenic. Arsenic removal was evaluated during 3 months and its final percentage of the experiment was 60%.

  14. A Preliminary Study on Bucket Foundations under Transient Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo; Nielsen, Søren Kjær;

    2013-01-01

    This study aims at investigating the behaviour of monopod bucket foundations through a physical model. The foundation is installed in dense water-saturated sand and is subjected to lateral load applied at different rates. The different loading rates allow for exploring the patterns of response...... of bucket foundations in different drainage conditions. Particular focus is given to the rapid loading response of the foundation (simulating a 50 year wave or emergency stop of a wind turbine). Important knowledge on the pore pressure development within and around the foundation during loading is achieved....

  15. Preliminary Problem Definition Study on Munitions-Related Chemicals.

    Science.gov (United States)

    1979-04-01

    literature; how- S ever, Sander et al. (1975a, b) studied the effect of N-nitrosomorpholine in a series of experiments with cress plants (Lepidiwu sativum...Adenomas by Amines or Ureas Plus Nitrite and by N-Nitroso Compounds: Effect of Ascorbate, Gallic Acid, Thiocyanate, and Caffine ," j. Nat’l Cancer instit...Washington, D.C. Garber, K. (1970), "Air Pollution by Heavy-Metal-Containing Dusts. Effects on Plants ." LandAirt, Forsch, Sonderh., 25, 59-68

  16. Preliminary Clinical Study of Intra-vas Device

    Institute of Scientific and Technical Information of China (English)

    吴伟雄; 袁石锦; 陈振文; 谷翊群; 李世勤

    1994-01-01

    Fifty-one volunteers with implanted intravas device (IVD ) in comparison with 40 volunteers undergone no-scalpel vasectomy have been recruited for 1 to 3 years clinical follow-up study, The results demonstrate that efficacy rates of contraception in both the IVD group and the vasectomy group are 100%, Sixteen out of thirty - one volunteers (51.6% ) in the IVD group were found to have glucosidase activity in their seminal plasma 1 to 3 years after the operation. Only 12 subjects in the IVD

  17. Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines

    Directory of Open Access Journals (Sweden)

    Sushil Kumar

    2011-01-01

    Full Text Available A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism, 5-HTP induced head twitches (5-HT2A antagonism and catalepsy studies in albino mice. The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserine and risperidone was assessed by calculating from a set of physiochemical properties using software programs. The test compounds (3a-j demonstrated good similarity values with respect to the standard drugs. Among them, compound 3d has emerged as an important lead compound showing potential atypical antipsychotic like profile.

  18. ANAEROBIC MEMBRANE BIOREACTORS FOR DOMESTIC WASTEWATER TREATMENT. PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    Luisa Vera

    2014-12-01

    Full Text Available The operation of submerged anaerobic membrane bioreactors (SAnMBRs for domestic wastewaters treatment was studied in laboratory scale, with the objective to define sustainable filtration conditions of the suspensions along the process. During continuous experiments, the organic matter degradation by anaerobic way showed an average DQOT removal of 85% and 93%. Indeed, the degradation generated biogas after 12 days of operation and its relative methane composition was of 60% after 25 days of operation. Additionally, the comparison between membrane bioreactors (MBRs performance in aerobic and anaerobic conditions in filterability terms, reported that both systems behave similarly once reached the stationary state.

  19. Magnitude of relationship between burnout and absenteeism: a preliminary study.

    Science.gov (United States)

    Gil-Monte, Pedro R

    2008-04-01

    This study examined the influence of guilt related to a negative attitude toward patients and its relation with burnout and absenteeism. The sample consisted of 717 nursing professionals. Depersonalization was evaluated by the Maslach Burnout Inventory and Guilt was evaluated by one item. To estimate Absenteeism, participants were asked about the number of workdays they had missed in the past year. Hierarchical multiple regression analyses make it possible to conclude that guilt explains work absenteeism, and the interaction between depersonalization and guilt (Incr. R2 = .008, p burnout and symptoms such as absenteeism.

  20. QUALITY CONTROL PARAMETERS OF BRIHAT DASHAMULA TAILA: A PRELIMINARY STUDY

    Directory of Open Access Journals (Sweden)

    Sharma Vinay

    2011-05-01

    Full Text Available Standard analytical parameters of a number of Ayurvedic oils have been described in API. Brihat Dashamula Taila is one of the most commonly used oil by Ayurvedic Physicians. But there no standard analytical parameters are available in any authentic texts. Therefore this study aimed to set the quality control parameters with SOP of Brihat Dashamula Taila and found values like Refractive index (1.47 at 400C, specific gravity (0.923 at 250C Acid value (1.2, Iodine value (92.6 and Saponification value (86.34 may be considered as standard.

  1. Zero emission city. Preliminary study; Null-Emissions-Stadt. Sondierungsstudie

    Energy Technology Data Exchange (ETDEWEB)

    Diefenbach, N.; Enseling, A.; Werner, P.; Flade, A.; Greiff, R.; Hennings, D.; Muehlich, E.; Wullkopf, U.; Sturm, P.; Kieslich, W.; Born, R.; Grossklos, M.; Hatteh, R.; Mueller, K.; Ratschow, A.; Valouch-Fornoff, C.

    2002-10-01

    The idea of a 'zero emission city' is investigated by the Institut Wohnen und Umwelt on behalf of the Federal Minister of Education and Research. After describing the current situation and defining the key parameters of a 'zero emission city', settlement structures, power supply, production processes and transportation are analyzed and linked with the communal action level to obtain a framework for research, activities and actions. The study ends with recommendations for a research programme 'zero emission city'. (orig.) [German] Die von den Staedten der Industrielaender ausgehenden Emissionen stellen im Hinblick auf die globalen Belastungen wie z.B. Treibhauseffekt, Ozonabbau und Versauerung das Hauptproblem dar. Aus diesem Grunde bietet es sich an, den Gedanken der 'Null-Emissions-Stadt', der Vision einer moeglichst emissionsfreien Stadt, aufzugreifen und auf seine Tragfaehigkeit fuer innovative Handlungsmodelle forschungsstrategisch zu ueberpruefen. Das Bundesministerium fuer Bildung und Forschung hat das Institut Wohnen und Umwelt beauftragt, in einer Sondierungsstudie dieser Fragestellung nachzugehen. Nach der Festlegung der Ausgangsbedingungen und Eckpunkte der Vision 'Null-Emissions-Stadt' und der Analyse der vier Handlungsfelder Siedlungsstrukturen, Energieversorgung, Produktionsprozesse (Kreislaufwirtschaft) und Verkehr werden diese aufgegriffen und mit der kommunalen Handlungsebene verknuepft und zu einem Forschungs-, Handlungs- und moeglichen Aktionsrahmen zusammengefuegt. Die Studie schliesst mit Hinweisen fuer die Gestaltung eines Forschungsprogramms 'Null-Emissions-Stadt'. (orig.)

  2. Preliminary study on hydrogeology in tectonically active areas.

    Energy Technology Data Exchange (ETDEWEB)

    Lowry, Thomas Stephen; Lappin, Allen R.; Gettemy, Glen L.; Jensen, Richard Pearson; Arnold, Bill Walter; James, Scott Carlton; Lee, Moo Yul; Meier, Diane A.

    2006-09-01

    This report represents the final product of a background literature review conducted for the Nuclear Waste Management Organization of Japan (NUMO) by Sandia National Laboratories, Albuquerque, New Mexico, USA. Internationally, research of hydrological and transport processes in the context of high level waste (HLW) repository performance, has been extensive. However, most of these studies have been conducted for sites that are within tectonically stable regions. Therefore, in support of NUMO's goal of selecting a site for a HLW repository, this literature review has been conducted to assess the applicability of the output from some of these studies to the geological environment in Japan. Specifically, this review consists of two main tasks. The first was to review the major documents of the main HLW repository programs around the world to identify the most important hydrologic and transport parameters and processes relevant in each of these programs. The review was to assess the relative importance of processes and measured parameters to site characterization by interpretation of existing sensitivity analyses and expert judgment in these documents. The second task was to convene a workshop to discuss the findings of Task 1 and to prioritize hydrologic and transport parameters in the context of the geology of Japan. This report details the results and conclusions of both of these Tasks.

  3. Preliminary study: voluntary food intake in dogs during tryptophan supplementation.

    Science.gov (United States)

    Fragua, Víctor; González-Ortiz, Gemma; Villaverde, Cecilia; Hervera, Marta; Mariotti, Valentina Maria; Manteca, Xavier; Baucells, María Dolores

    2011-10-01

    Tryptophan, a precursor of important molecules such as serotonin, melatonin and niacin, is an essential amino acid for dogs. In pigs, tryptophan supplementation has been shown to induce a significant increase in food intake. The aim of the present study was to assess whether long-term tryptophan supplementation increases voluntary food intake in dogs and to observe whether this was accompanied by a change in serum ghrelin. In the present study, sixteen adult Beagle dogs were used, with four male and four female dogs fed diets supplemented with tryptophan (1 g/dog per d) during 81 d (Trp) and four male and four female dogs that were not supplemented (control). A voluntary food intake test was performed during 5 d following the supplementation period. The Trp group tended to show a higher food intake during the voluntary food intake test (58.0 (SE 5.37) v. 77.5 (SE 3.65) g/kg metabolic weight per d; P = 0.074). No significant differences were found for serum ghrelin concentrations.

  4. [Preliminary study on pollination biology of Tulipa edulis].

    Science.gov (United States)

    Wu, Zhengjun; Zhu, Zaibiao; Guo, Qiaosheng; Xu, Hongjian; Ma, Hongliang; Miao, Yuanyuan

    2012-02-01

    Current study on the pollination biology of Tulipa edulis was conducted to investigate its pollination characteristics and to provide references for artificial domestication and breeding of T. edulis. Flowering dynamics, pollinators, morphology and structure of flower were observed. Different methods were adopted to evaluate the pollen vitality, and benzidine-H2O2 method was used for estimation of the stigma receptivity. Breeding system was evaluated based on out-crossing index (OCI) , pollen-ovule ratio (P/O) and the results of emasculation, bagging and artificial pollination studies. The flower of T. edulis showed typical characteristics of Liliaceae. The pollen remained viable to some extent during all the anthesis and peaked within three days after blossoming. Stigma acceptability peaked in the first day of blossom and dwindled away in the next four days. The type of breeding system of T. edulis was facultative xenogamy, three species of Halictus are the main pollination insects. The type of breeding system of T. edulis was facultative xenogamy, withal cross-pollination give priority to self-pollination, and the insects play a main role on the pollination of T. edulis, further validation are needed to judge if the wind is helpful to pollination.

  5. Effects of vibrotactile vestibular substitution on vestibular rehabilitation - preliminary study,

    Directory of Open Access Journals (Sweden)

    Cibele Brugnera

    2015-12-01

    Full Text Available ABSTRACT INTRODUCTION: Some patients with severe impairment of body balance do not obtain adequate improvement from vestibular rehabilitation (VR. OBJECTIVE: To evaluate the effectiveness of Vertiguard(tm biofeedback equipment as a sensory substitution (SS of the vestibular system in patients who did not obtain sufficient improvement from VR. METHODS: This was a randomized prospective clinical study. Thirteen patients without satisfactory response to conventional VR were randomized into a study group (SG, which received the vibrotactile stimulus from Vertiguard(tm for ten days, and a control group (CG, which used equipment without the stimulus. For pre- and post-treatment assessment, the Sensory Organization Test (SOT protocol of the Computerized Dynamic Posturography (CDP and two scales of balance self-perception, Activities-specific Balance Confidence (ABC and Dizziness Handicap Inventory (DHI, were used. RESULTS: After treatment, only the SG showed statistically significant improvement in C5 (p = 0.007 and C6 (p = 0.01. On the ABC scale, there was a significant difference in the SG (p= 0.04. The DHI showed a significant difference in CG and SG with regard to the physical aspect, and only in the SG for the functional aspect (p = 0.04. CONCLUSION: The present findings show that sensory substitution using the vibrotactile stimulus of the Vertiguard(tm system helped with the integration of neural networks involved in maintaining posture, improving the strategies used in the recovery of body balance.

  6. A preliminary study of airborne microbial biodiversity over Peninsular Antarctica.

    Science.gov (United States)

    Hughes, K A; McCartney, H A; Lachlan-Cope, T A; Pearce, D A

    2004-07-01

    This study used PCR-based molecular biological identification techniques to examine the biodiversity of air sampled over Rothera Point (Antarctic Peninsula). 16S rDNA fragments of 132 clones were sequenced and identified to reveal a range of microorganisms, including cyanobacteria, actinomycetes, diatom plastids and other uncultivated bacterial groups. Matches for microorganisms that would be considered evidence of human contamination were not found. The closest matches for many of the sequences were from Antarctic clones already in the databases or from other cold environments. Whilst the majority of the sequences are likely to be of local origin, back trajectory calculations showed that the sampled air may have travelled over the Antarctic Peninsula immediately prior to reaching the sample site. As a result, a proportion of the detected biota may be of non-local origin. Conventional identification methods based on propagule morphology or culture are often inadequate due to poor preservation of characteristic features or loss of viability during airbome transfer. The application of molecular biological techniques in describing airbome microbial biodiversity represents a major step forward in the study of airborne biota over Antarctica and in the distribution of microorganisms and propagules in the natural environment.

  7. Sexual hormone serum levels and temporomandibular disorders. A preliminary study.

    Science.gov (United States)

    Landi, Nicola; Lombardi, Ilaria; Manfredini, Daniele; Casarosa, Elena; Biondi, Katya; Gabbanini, Massimo; Bosco, Mario

    2005-02-01

    The aim of the present study was to investigate the role of sexual hormones in a young adult population affected by articular forms of temporomandibular disorders (TMD), measuring 17beta-estradiol and progesterone serum levels. In the study, we included 40 patients (20 males and 20 females) with a Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) axis I group II diagnosis of disk displacement and/or group III diagnosis of arthralgia, osteoarthritis or osteoarhrosis, and 32 healthy controls. In female patients, blood samples were collected in follicular and luteal phases of the same menstrual cycle, while only one blood sample was drawn in male patients. Serum levels of estradiol and progesterone were determined using a radioimmunoassay and the comparison between the two groups was performed using a t test. Regarding estradiol, our results showed significantly higher serum levels in patients affected by TMD than in healthy controls, both in males (p hormones, these data suggest that high serum estrogen levels might be implicated in the physiopathology of TMD.

  8. A preliminary study of periodontitis and vascular calcification compound model

    Institute of Scientific and Technical Information of China (English)

    MENGYun; DENGJing; PanKe-qing

    2015-01-01

    Objective This experiment is desired to establish a compound model of chronic periodontitis and vascular calcification,so as to study the relation of periodontal and vascular calcification.Methods Forty male Wistar rats were randomly divided into:control group(group C),periodontitis group(group CP),vascular calcification group(group VDN),compound group (group CP+VDN).Every groups accepted the corresponding manages to establish the animal model.Eight weeks later,al the rats were sacrificed and the fol owing items were observed:inflam-matory factor in serum were tested,Hematoxylin-eosin staining(HE)staining of vascular tissue were taken to test.Results Through detection of periodontal tissue,serum and vascular tissue,an-imal models were successful.Histopathologic observation revealed:obvious inflammation of periodontal tissue was obversed in group CP and CP+VDN.The red Mineralized nodules deposition in group VDN and CP+VDN were higher than in group C and CP(P<0.05)by HE staining,and that in group CP+VDN was significantly higher than in group VDN(P<0.05);Animals in group CP+VDN showed higher level of IL-1 in serum than that in group CP,VDN and C.Conclusion This study has demonstrated that periodontitis have some promoting ef ect on vascular cal-cification.

  9. Preliminary studies on immobilization of lipase using chicken eggshell

    Science.gov (United States)

    Salleh, S.; Serri, N. A.; Hena, S.; Tajarudin, H. A.

    2016-06-01

    A few advantages of enzyme immobilization are reusability of expensive enzyme, improvement of stability and activity compared to crude enzyme. Various organic components can be used as carrier for enzyme immobilization such as chicken eggshell. It can be used as a carrier for immobilization as its mineral component mostly contains of calcium carbonate. In the present study, Tributyrin method was used to test enzyme activity of Rhizomucour Miehei, Candida Antarctica and Candida Rugosa. Rhizomucour Miehei shows the highest enzyme activity (360.8 mol/min/mL lipase) and was used in further experiment. Experiment was continued to study incubation time for lipase immobilization on eggshell (1-4 hours) and reaction time of esterification of sugar ester (0-72 hours). Two hours incubation time for lipase immobilization was observed and gives the highest yield of sugar ester (78.13%). Fructose and stearic acid as substrate was used for the production of sugar ester. The highest percentage of sugar ester production was shown at 36 hours of reaction time.

  10. Marine actinomycetes from Madeira Archipelago preliminary taxonomic studies

    Directory of Open Access Journals (Sweden)

    Ilda Santos Sanches

    2014-06-01

    Full Text Available The oceans cover 70 % of the Earth´s surface and harbor most of the planet´s biodiversity. However the microbiological component of this diversity remains relatively unexplored. Marine actinomycetes, are a robust resource of chemically prolific novelty. Producing structurally unique biological active secondary metabolites, generating a valuable source for innovative biotechnology and drug discovery[1,2]. As a consequence, the ecological role of actinomycetes and their marine ecosystems may no longer be neglected. It is crucial to move our research efforts into ocean regions for which we know little or nothing about the indigenous microbial diversity. The Portuguese Archipelago, Madeira is located in the Macaronesian Atlantic region, emerging from the African tectonic plate, found in the extreme south of the Tore-Madeira ridge, has a unique biogeography and biodiversity. These distinctive characteristics combined with the fact that Madeira have never been explored, as far as indigenous marine actinomycetes are concerned, makes it from the scientific point of view, the perfect target for our studies. From 662 marine sediment samples collected along Madeira Archipelago (Figure 1 during June of 2012, covering depths from 10-1310 m, a total of 421 actinomycete strains were isolated. In a previous study, an assemblage of 82 strains was selected for taxonomic identification, having into account representative morphological diversity characteristics of the actinomycetes, isolated from Madeira Archipelago. Based on 16S rRNA gene sequencing, it was observed that the genera Streptomyces, Micromonospora and Salinispora were predominant, 81% [3]. Additionally, in a recent study, our team selected 168 strains with Salinispora look-alike morphological features. From these 28 strains were identified as belonging to the seawater-obligate marine actinomycete genus Salinispora. Representing the first report of Salinispora spp. in the Macaronesian Atlantic Ocean

  11. Cognitive processes in criminal profile construction: a preliminary study.

    Science.gov (United States)

    Kocsis, Richard N; Middledorp, Jenny; Try, Andrew C

    2005-12-01

    This study undertook an empirically based examination of the cognitive processes associated with the accurate construction of a criminal psychological profile. This was accomplished by comparing the abilities of profilers and nonprofilers in two simulated profiling exercises that measured both profile accuracy and an individual's performance on various tests of memory and comprehension related to the case materials presented in each exercise. The results of these experiments suggest that an incremental relationship exists between comprehension of the case materials and accuracy of the profiles generated. In addition, the findings provide some tentative indications that the comprehension of case material in a narrative (i.e., written) format is an integral cognitive function to proficient profiling.

  12. Preliminary Study of Stereotactic Radiotherapy for Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    From March 1997 to November 1999, 45 patients with lung cancer were treated by astereotactic radiotherapy, with 15 cases treated by a stereotactic radiotherapy alone, and 30 cases by the external radiotherapy plus stereotactic radiotherapy. The clinical target volume was 1.89-187. 26 cm3 with the median being 18. 17 cm3. The doses of plan target volume (PTV) edge was 16-30 Gy/2-3 times and the doses of center was 120 % to 150 % of PTV edge doses. The overall response rate was 84.4 % (38/45), with 11 complete response (CR) and 27 partial response (PR). This study confirmed that the stereotactic radiotherapy is a safe and effective therapy for lung cancer. For those early-stage patients who can tolerate neither operation nor even conventional radiotherapy for various reasons, it can both achieve therapeutic purpose and improve quality of life.

  13. Preliminary Exploratory Study of Different Phase II Collimators

    CERN Document Server

    Lari, L; Bertarelli, A; Bracco, C; Brugger, M; Cerutti, F; Dallocchio, Alessandro; Doyle, E; Ferrari, A; Keller, L; Lundgren, S; Markiewicz, T; Mauri, M; Roesler, S; Sarchiapone, L; Smith, J; Vlachoudis, V

    2008-01-01

    The LHC collimation system is installed and commissioned in different phases, following the natural evolution of the LHC performance. To improve cleaning efficiency towards the end of the low beta squeeze at 7TeV, and in stable physics conditions, it is foreseen to complement the 30 highly robust Phase I secondary collimators with low impedance Phase II collimators. At this stage, their design is not yet finalized. Possible options include metallic collimators, graphite jaws with a movable metallic foil, or collimators with metallic rotating jaws. As part of the evaluation of the different designs, the FLUKA Monte Carlo code is extensively used for calculating energy deposition and studying material damage and activation. This report outlines the simulation approach and defines the critical quantities involved.

  14. Preliminary Design Study for a National Digital Seismograph Network

    Science.gov (United States)

    Peterson, Jon; Hutt, Charles R.

    1981-01-01

    Introduction Recently, the National Research Council published a report by the Panel on National, Regional, and Local Seismograph Networks of the Committee on Seismology in which the principal recommendation was for the establishment of a national digital seismograph network (NDSN). The Panel Report (Bolt, 1980) addresses both the need and the scientific requirements for the new national network. The purpose of this study has been to translate the scientific requirements into an instrumentation concept for the NSDS. There are literally hundreds, perhaps thousands, of seismographs in operation within the United States. Each serves an important purpose, but most have limited objectives in time, in region, or in the types of data that are being recorded. The concept of a national network, funded and operated by the Federal Government, is based on broader objectives that include continuity of time, uniform coverage, standardization of data format and instruments, and widespread use of the data for a variety of research purposes. A national digital seismograph network will be an important data resource for many years to come; hence, its design is likely to be of interest to most seismologists. Seismologists have traditionally been involved in the development and field operation of seismic systems and thus have been familiar with both the potential value and the limitations of the data. However, in recent years of increasing technological sophistication, the development of data sstems has fallen more to system engineers, and this trend is likely to continue. One danger in this is that the engineers may misinterpret scientific objectives or subordinate them to purely technological considerations. Another risk is that the data users may misuse or misinterpret the data because they are not aware of the limitations of the data system. Perhaps the most important purpose of a design study such as this is to stimulate a dialogue between system engineers and potential data users

  15. Blackened bronchoalveolar lavage fluid in crack smokers. A preliminary study.

    Science.gov (United States)

    Greenebaum, E; Copeland, A; Grewal, R

    1993-11-01

    A retrospective study was performed on heavily pigmented pulmonary cytologic specimens from 14 hospital patients to determine the clinical features distinguishing these cases. The lavage fluid or sputum in each case was turbid and gray or black, exceeding the blackness usually seen in heavy tobacco smokers dwelling in the same urban environment. Excessive carbonaceous material was observed in the cytoplasm of pulmonary alveolar macrophages or the extracellular compartment of the smears. The latter feature is not seen in cigarette smokers. Many other pigmentary sources were ruled out, including melanin, hemosiderin, medicinal charcoal, India ink, and hematoxylin crystals. The common feature of the patients was that they recently or currently smoked the crack form of cocaine heavily; five patients also had positive toxicologic results for cocaine at admission. The authors suggest that blackened bronchoalveolar lavage fluid indicates the possibility of crack cocaine smoking and the associated sequelae, particularly when the carbonaceous material is present in the extracellular compartment.

  16. Polarization in Thermal Emission from Hot Jupiters: Preliminary Studies

    Science.gov (United States)

    Kopparla, Pushkar; Natraj, Vijay; Yung, Yuk; Spurr, Robert

    2016-10-01

    Scattering of thermal emission from a deep, hot region by high altitude atmospheric particles induces polarization in the scattered light. However, symmetries on a spherical planet with a uniform spatial distribution of scattering particles usually result in zero net polarization. If the symmetry is broken, either by rotation induced oblateness or by spatially inhomogeneous cloud or haze particle distributions, polarization may become observable. Additionally, variation of temperatures across the planetary disc could also contribute to asymmetries, giving us a new way to measure the day-night temperature contrast on hot exoplanets. We perform modeling studies using a multiple scattering, radiative transfer model for polarized light to understand how to distinguish between various symmetry breaking phenomena and map an observed polarization to a specific atmospheric state. The models can be used to predict the most suitable candidates for observation, and once observations are available, to retrieve various parameters of interest.

  17. A preliminary study of cryosphere service function and value evaluation

    Institute of Scientific and Technical Information of China (English)

    XIAO Cun-De; WANG Shi-Jin; QIN Da-He

    2015-01-01

    Cryosphere science research and development (R&D) has been strongly committed to public service, integrating natural sciences with socioeconomic impacts. Owing to the current shift from purely natural cryosphere scientific research to linking cryosphere science with so-cioeconomic and cultural science, cross-disciplinary research in this field is emerging, which advocates future cryosphere science research in this field. Utilizing the cryosphere service function (CSF), this study establishes CSF and its value evaluation system. Cryosphere service valuation can benefit the decisionmakers' and public's awareness of environmental protection. Implementing sustainable CSF utilization strategies and macroeconomic policymaking for global environmental protection will have profound and practical significance as well as avoid environmental degradation while pursuing short-term economic profits and achieving rapid economic development.

  18. Proton MR spectroscopy in neuroborreliosis: a preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Ustymowicz, A.; Tarasow, E.; Walecki, J. [Department of Radiology, Medical Academy, Bialystok (Poland); Zajkowska, J.; Hermanowska-Szpakowicz, T. [Department of Infectious Diseases and Neuroinfections, Medical Academy, Bialystok (Poland)

    2004-01-01

    We report results of a magnetic resonance spectroscopy (MRS) study in 12 patients with neuroborreliosis. We used a PRESS sequence, placing an 8 cm{sup 3} voxel in normal-appearing white matter of the frontal lobe. Peaks indicating N-acetylaspartate (NAA), choline (Cho), creatine (Cr), myo-inositol (mI), lipids (Lip) and lactate (Lac) were identified and ratios of NAA/Cr, Cho/Cr, mI/Cr, Lip/Cr, Lac/Cr calculated. Significant increases in Cho/Cr and Lip/Cr were noted. No abnormality was found in mean NAA/Cr and Lac/Cr, but in four patients there was a decreased NAA peak; mI/Cr ratio was slightly increased. Although the spectroscopic profile in patients with neuroborreliosis seems to be nonspecific, MRS might be useful for assessing tissue damage of the central nervous system. (orig.)

  19. Preliminary study of chemical compositional data from Amazon ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Toyota, Rosimeiri G.; Munita, Casimiro S.; Luz, Fabio A. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)]. E-mail: rosimeiritoy@yahoo.com.br; Neves, Eduardo G. [Museu de Arqueologia e Etnolgia, Sao Paulo, SP (Brazil)]. E-mail: egneves@usp.br; Oliveira, Paulo M.S. [Sao Paulo Univ., SP (Brazil). Escola Politecnica. Inst. de Matematica e Estatistica]. E-mail: poliver@usp.br

    2005-07-01

    Eighty seven ceramic samples from Acutuba, Lago Grande and Osvaldo archaeological sites located in the confluence of the rivers Negro and Solimoes were submitted to chemical analysis using instrumental neutron activation analysis to determine As, Ba, Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Lu, Rb, Na, Nd, Sb, Sc, Sm, Ta, Tb, Th, Yb, Zn, and U. The database were studied using the Mahalanobis distance, and discriminant analysis. The results showed that the ceramics of each site differ from each other in chemical composition and that they form three different groups. Chemical classification of the ceramics suggests that vessels were made locally, as only ceramics from the same area show homogeneity of data. (author)

  20. Psychological Preparation for Paralympic Athletes: A Preliminary Study.

    Science.gov (United States)

    Blumenstein, Boris; Orbach, Iris

    2015-07-01

    Since the first Paralympics in 1960 there has been an increase in social and scientific interest in Paralympic athletes' personality, their preparation, and their sport results. During the last 20 yr, researchers and practitioners have been focused on psychological-skills programs for athletes with disabilities. The purpose of this article was to describe a psychological-preparation program for Israeli Paralympic athletes. Two subprograms, the learning-modification-application approach and the Simulation Training Exercise Program, were adapted to athletes' disability and sport demands. Two case studies, from table tennis and sailing (Sonar 3-person keelboat), are described to demonstrate how systematic sport psychology preparation can be effectively integrated into the training process of Paralympic athletes. Some recommendations for Paralympic athletes are presented.

  1. Preliminary study on radiocarbon AMS dating of pollen

    Institute of Scientific and Technical Information of China (English)

    周卫建; 周杰; 萧家仪; D.Donahue; A.J.T.Jull

    1999-01-01

    17 samples were collected from aeolian and lacustrine profiles within the environment sensitive zone of the Loess Plateau, and an experimental method was established which is suitable for pollen extraction from aeolian sediment. A comparative study of pollen dating was carried out using the accelerator mass spectrometry (AMS) 14C dating of known age samples, and then an experiment with the pollen concentrates was performed. The results indicate that pollen that has been deposited simultaneously with sediment in a stable environment can provide reliable ages. This technique will provide a way of improving the chronological framework for the Loess Plateau since the late Pleistocene. The 14C dating was combined with field investigations, and from the geological record within this zone, evidence was extracted of four major monsoon precipitation changes during the transition from the late Pleistocene to Holoeene.

  2. A Preliminary Study of Surface Temperature Cold Bias in COAMPS

    Energy Technology Data Exchange (ETDEWEB)

    Chin, H-N S; Leach, M J; Sugiyama, G A; Aluzzi, F J

    2001-04-27

    It is well recognized that the model predictability is more or less hampered by the imperfect representations of atmospheric state and model physics. Therefore, it is a common problem for any numerical models to exhibit some sorts of biases in the prediction. In this study, the emphasis is focused on the cold bias of surface temperature forecast in Naval Research Laboratory's three-dimensional mesoscale model, COAMPS (Coupled Ocean/Atmosphere Mesoscale Prediction System). Based on the comparison with the ground station data, there were two types of ground temperature cold biases identified in LLNL (Lawrence Livermore National Laboratory) operational forecasts of COAMPS over the California and Nevada regions during the 1999 winter and the 2000 spring. The first type of cold bias appears at high elevation regions covered by snow, and its magnitude can be as large as 30 F - 40 F lower than observed. The second type of cold bias mainly exists in the snow-free clear-sky regions, where the surface temperature is above the freezing point, and its magnitude can be up to 5 F - 10 F lower than observed. These cold biases can affect the low-level stratification, and even the diurnal variation of winds in the mountain regions, and therefore impact the atmospheric dispersion forecast. The main objective of this study is to explore the causes of such cold bias, and to further the improvement of the forecast performance in COAMPS. A series of experiments are performed to gauge the sensitivity of the model forecast due to the physics changes and large-scale data with various horizontal and vertical resolutions.

  3. Self-acceptance of stuttering: A preliminary study.

    Science.gov (United States)

    De Nardo, Thales; Gabel, Rodney M; Tetnowski, John A; Swartz, Eric R

    2016-01-01

    This study explored the relationship between self-acceptance of stuttering and (1) psychosocial factors (self-esteem, hostility towards others, emotional support, and perceived discrimination); (2) treatment history (support group participation, therapy duration, and perceived therapy success); and (3) previously reported variables in self-acceptance of stuttering, which include age and stuttering severity. Participants were 80 adults who stutter who were recruited with assistance from the National Stuttering Association and Board Certified Specialists in Fluency Disorders. Participants completed an electronic survey composed of an acceptance of stuttering scale, psychosocial scales, and a participant information questionnaire. Statistical analysis identified significant correlations between participants' reports of self-acceptance of stuttering and self-esteem, perceived discrimination, hostility towards others, and perceived therapy outcome. Self-esteem was positively correlated with self-acceptance, while hostility towards others and perceived discrimination was negatively correlated with self-acceptance. Participants who perceived their therapy outcome to be successful were significantly more likely to report higher levels of self-acceptance. No significant relationships were found between self-acceptance of stuttering and support group participation, emotional support, stuttering severity, and participant age. This exploratory investigation has provided a foundation for future studies on the self-acceptance of stuttering. The findings indicate common psychosocial variables in self-acceptance of stuttering and of other disabilities. The significant relationships between self-acceptance of stuttering and psychosocial and therapeutic variables found need to be further explored to identify its causalities and clinical implications. The reader will be able to (1) discuss the importance of assessing self-acceptance of stuttering, (2) summarize the literature on self

  4. Weight loss and P wave dispersion: a preliminary study.

    Science.gov (United States)

    Falchi, Anna Giulia; Grecchi, Ilaria; Muggia, Chiara; Tinelli, Carmine

    2014-01-01

    The aim of this study is to investigate if therapeutic weight loss reduces P wave dispersion. 20 obese patients (10 males and 10 females), part of a randomized clinical trial, were examined over a 6 month period. They were treated with a diet, aiming at 5% weight loss at the 6th month. After physical examination, they underwent laboratory tests, bioelectrical impedance analysis and a electrocardiogram (ECG). ECGs were transferred to a personal computer via a scanner and then magnified 400 times. We examined at baseline and at the 6th month, maximum and minimum P-wave duration, P-wave dispersion and heart rate. Comparing responders (patients who lost 5% of weight at t6) and not responders (who lost less than 5%), responders showed a significant reduction of P wave dispersion value (-0.38 [SD: 0.35] mm equal to -32.3 [SD: 11.3] % p=0.00001). All responders present a reduction of P wave dispersion, while for not-responders this is no longer evident. Finally, a good degree of correlation (r=0.54) between P wave dispersion difference and the decrease of weight was noticed. Females have a better response in P dispersion reduction strictly connected with their weight loss with a good correlation, (r=0.7, p=0.002), versus a moderate correlation evidenced in males (r=0.5, p=0.011). P wave duration and dispersion are significantly reduced in patients who lost more than 5% of weight and this decrease is highly related to the extent of weight loss. Copyright © 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

  5. Preliminary acute toxicity study on imidacloprid in Swiss albino mice

    Directory of Open Access Journals (Sweden)

    Preeti Bagri

    2013-12-01

    Full Text Available Aim: To ascertain the maximum tolerated dose (MTD and to investigate the acute oral toxic effects of imidacloprid towards Swiss albino male mice.Materials and Methods: The MTD of imidacloprid was determined in pilot dose range finding study following the standard method. Animals were observed for toxic signs and symptoms after oral administration of MTD of imidacloprid in single dose. The body weights of animals were recorded on alternate day. Animals were sacrificed on 14th day and changes in hematological parameters (Hb, TEC, TLC and DLC and morphometric measurements (length, breadth, thickness and weight of various body organs (heart, liver, spleen, kidney, testis and epididymis were examined. The student's t-test was applied to statistically analyze the results.Results: The MTD of imidacloprid was determined to be 110 mg/kg body weight. The sign and symptoms of acute toxicity were ataxia, rigidity and fasciculation of muscles, protrusion of eye ball and tremors of head. Imidacloprid treatment resulted in decreased body weight gain as compared to the control group. The changes in hematological parameters were not significant between imidacloprid treated and control groups. Also the values of relative organ weights and morphometric measurements of various body organs did not differ significantly between the control and imidacloprid treated animals.Conclusions: MTD of imidacloprid in Swiss albino male mice through oral route was determined for the first time. Study revealed a non-toxic effect of imidacloprid on body weight, relative organs weight, hematological parameters and morphometric measurements of various body organs in mice.

  6. Wind energy in electric power production, preliminary study

    Science.gov (United States)

    Lento, R.; Peltola, E.

    1984-01-01

    The wind speed conditions in Finland have been studied with the aid of the existing statistics of the Finnish Meteorological Institute. With the aid of the statistics estimates on the available wind energy were also made. Eight hundred wind power plants, 1.5 MW each, on the windiest west coast would produce about 2 TWh energy per year. Far more information on the temporal, geographical and vertical distribution of the wind speed than the present statistics included is needed when the available wind energy is estimated, when wind power plants are dimensioned optimally, and when suitable locations are chosen for them. The investment costs of a wind power plant increase when the height of the tower or the diameter of the rotor is increased, but the energy production increases, too. Thus, overdimensioning the wind power plant in view of energy needs or the wind conditions caused extra costs. The cost of energy produced by wind power can not yet compete with conventional energy, but the situation changes to the advantage of wind energy, if the real price of the plants decreases (among other things due to large series production and increasing experience), or if the real price of fuels rises. The inconvinience on the environment caused by the wind power plants is considered insignificant. The noise caused by the plant attenuates rapidly with distance. No harmful effects to birds and other animals caused by the wind power plants have been observed in the studies made abroad. Parts of the plant getting loose during an accident, or ice forming on the blades are estimated to fly even from a large plant only a few hundred meters.

  7. Oxidative damage in young alcohol drinkers: A preliminary study.

    Science.gov (United States)

    Rendón-Ramírez, Adela; Cortés-Couto, Miriam; Martínez-Rizo, Abril Bernardette; Muñiz-Hernández, Saé; Velázquez-Fernández, Jesús Bernardino

    2013-11-01

    Oxidative damage (OD) biomarkers have been used to evaluate metabolic stress undergone by alcoholic individuals. In alcoholic patients, these biomarkers are usually measured at late stages, i.e., when the alcoholic patients are showing clear signs of impaired hepatic function. OD biomarkers are sensitive indicators of impaired metabolic function, and might be useful in early stages of alcohol consumption to identify individuals who are at greater risk of damage in later stages of alcohol consumption. The aim of the present work was to evaluate some OD biomarkers in young people at early stages of alcohol consumption. The study was carried out in a group of young people (18-23 years old) who drank alcohol, Youngsters Exposed to Alcohol (YEA) with an average intake of 118 g of ethanol/week, and a control group (CG) of non-drinkers. Blood counts, alcohol dehydrogenase (ADH) activity, glutathione peroxidase (GSH-Px) activity, oxidative damage to DNA, and lipid peroxidation were determined in both groups. The anthropometric and blood parameters of both groups were similar and no clinical symptoms of hepatic damage were observed. Nevertheless, ADH activity, lipid peroxidation, and percentage of damaged DNA cells were higher in the YEA group than in the control group. In contrast, GSH-Px activity was lower in the YEA group than in the control group. Alteration in OD biomarkers can be found in individuals with 4-5 years of alcohol drinking history. To our knowledge, this is the first study giving evidence of OD in individuals at early stages of alcohol abuse. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. Focal neuropathies following percutaneous nephrolithotomy (PCNL)--preliminary study.

    Science.gov (United States)

    Nasseh, Hamidreza; Pourreza, Farshid; Saberi, Alia; Kazemnejad, Ehsan; Kalantari, Behnam Behmardi; Falahatkar, Siavash

    2013-01-01

    Einleitung: Postoperative neurologische Komplikationen bei operativem Eingriff an Becken und Niere sind ein bekanntes klinisches Problem und deren Krankheitsverläufe sind wichtig. Wir planten diese Studie, um die Prävalenz und die Risikofaktoren derartiger Komplikationen nach perkutaner Nephrolithotomie (PCNL) zu erfassen.Material und Methoden: Von Februar bis Juli 2011 wurde eine Querschnittstudie an 68 PCNL-Fällen durchgeführt. Die demographischen Daten und die Operationsberichte wurden ausgewertet und umfassende neurologische und körperliche Untersuchungen wurden vor und nach dem chirurgischen Eingriff vorgenommen. Die Daten wurden mit der Software SPSS 18 analysiert.Ergebnisse: In die Studie einbezogen wurden 30 männliche (46,2%) und 35 (53,8%) weibliche Patienten mit einem mittleren Alter von 47,9 ± 11,47 Jahren. Bei 8 Patienten (12,31%), bei 4 Männern und 4 Frauen, wurden im Bereich des interkostalen und lumbosakralen Plexus sensorische neurologische Komplikationen gefunden. Die am häufigsten betroffenen Dermatome und Nerven waren im Bereich T 12 (8 Fälle). Es gab eine signifikante Korrelation zwischen der Dauer des chirurgischen Eingriffes und dem Vorkommen von sensorischen Komplikationen (p<0,010). Der höchste Abfall der Hämoglobinkonzentration nach dem chirurgischen Eingriff trat bei Patienten mit neurologischen Komplikationen auf (p<0,001). Es gab keine Korrelation zwischen Alter, gewähltem Zugang, Diabetes mellitus, BMI, Bluthochdruck, Lagerung der Patienten und Ort des chirurgischen Eingriffs und den beobachteten sensorischen neurologischen Komplikationen.Schlussfolgerung: Verlängerte Dauer der PCNL und erhöhter Abfall der Hämoglobinkonzentration können zu einem erhöhten Risiko für einer Neuropathie führen. Größere prospektive Studien mit retroperitonealen bildgebenden Untersuchungen und mit Verlaufskontrollen bei den Patienten werden vorgeschlagen, um diese Komplikation besser zu verstehen.

  9. Preliminary studies of Brazilian wood using different radioisotopic sources

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Gilberto; Silva, Leonardo Gondim de Andrade e, E-mail: gcarval@ipen.br, E-mail: ftgasilva@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Due to availability and particular features, wood was one of the first materials used by mankind with a wide variety of applications. It can be used as raw material for paper and cellulose manufacturing; in industries such as chemical, naval, furniture, sports goods, toys, and musical instrument; in building construction and in the distribution of electric energy. Wood has been widely researched; therefore, wood researchers know that several aspects such as temperature, latitude, longitude, altitude, sunlight, soil, and rainfall index interfere with the growth of trees. This behavior explains why average physical-chemical properties are important when wood is studied. The majority of researchers consider density to be the most important wood property because of its straight relationship with the physical and mechanical properties of wood. There are three types of wood density: basic, apparent and green. The apparent density was used here at 12% of moisture content. In this study, four different types of wood were used: 'freijo', 'jequetiba', 'muiracatiara' and 'ipe'. For wood density determination by non-conventional method, Am-241, Ba-133 and Cs-137 radioisotopic sources; a NaI scintillation detector and a counter were used. The results demonstrated this technique to be quick and accurate. By considering the nuclear parameters obtained as half value layers and linear absorption coefficients, Cs-137 radioisotopic source demonstrated to be the best option to be used for inspection of the physical integrity of electric wooden poles and live trees for future works. (author)

  10. Preliminary Study on Causative Factors Leading to Construction Cost Overrun

    Directory of Open Access Journals (Sweden)

    Aftab Hameed Memon

    2011-07-01

    Full Text Available Cost is the fundamental component for any construction project. However, cost overrun is observed as one of the most frequently occurring issues in construction projects worldwide and need to be studied more to alleviate this issue in the future. This trend is more severe in developing countries where these overruns sometimes exceeds 100% of the anticipated cost of the project.   Like other countries, construction industry in Malaysia is also facing a lot of challenges such as the delay to complete the project in time, the expenditure exceeding the budget, the building defects and over dependent of foreign workers. The ultimate effects of project delay also results in exceeding cost. This leads to serious need of addressing the critical issue of construction cost overrun. To avoid construction cost overrun, very first and most important step is to identify and understand the causes and factors responsible for that. Hence, this paper is aimed to identify various factors responsible for construction cost overrun. Through a comprehensive study of literature review, common factors causing cost overrun resulting in identification of 78 factors were mapped in frequency table. A questionnaire survey and interviews were carried out amongst selected experienced personnel for expert opinion to identify the significant factors causing cost overrun in Malaysia. Five respondents were selected from each of the respondents groups including client, consultant and contractor. The questionnaire responses were analyzed by average index method, which resulted in identification of 59 common factors causing construction cost overrun in Malaysia. Results show that poor design & delays in Design, unrealistic contract duration & requirements imposed, lack of experience, late delivery of materials & equipment, relationship between management & labour, delay preparation & approval of drawings, inadequate planning & scheduling, poor site management & supervision and

  11. Preliminary study of application of Moringa oleifera resin as polymer electrolyte in DSSC solar cells

    Science.gov (United States)

    Saehana, Sahrul; Darsikin, Muslimin

    2016-04-01

    This study reports the preliminary study of application of Moringa oleifera resin as polymer electrolyte in dye-sensitized solar cell (DSSC). We found that polymer electrolyte membrane was formed by using solution casting methods. It is observed that polymer electrolyte was in elastic form and it is very potential to application as DSSC component. Performance of DSSC which employing Moringa oleifera resin was also observed and photovoltaic effect was found.

  12. Preliminary study of a wing-tip vortex using laser velocimetry

    Science.gov (United States)

    Takahashi, R. K.; Mcalister, K. W.

    1987-01-01

    Measurements have been made in the wake of a semi-span NACA 0015 airfoil with emphasis on the region of the wing tip vortex. The spanwise and streamwise velocity components were measured using a two-component laser Doppler velocimeter. The purpose of the study was to initiate the operation of a laser velocimeter system and to perform preliminary wake measurements in preparation for a more extensive study of the structure and near field development of a tip vortex.

  13. What is cholera?:A preliminary study on caretakers' knowledge in Bangladesh

    OpenAIRE

    Tamason, Charlotte Crim; Tulsiani, Suhella; Siddique, A.; Hoque, Bilqis Amin; Jensen, Peter Kjær Mackie

    2016-01-01

    Background: Cholera has afflicted the Indian sub-continent for centuries, predominantly in West Bengal and modern-day Bangladesh. This preliminary study aims to understand the current level of knowledge of cholera in female Bangladeshi caretakers, which is important in the outcome of the disease and its spread. A pilot study was conducted among 85 women in Bangladesh using qualitative questionnaires to explore the ability of female caretakers in identifying cholera and its transmission.Findin...

  14. Journal of Island Studies: preliminary ideas from 1991, and comments from 2015

    Directory of Open Access Journals (Sweden)

    Russell King

    2015-05-01

    Full Text Available Some preliminary thoughts were penned in 1991, on the founding of an academic journal devoted to the study of the world’s islands. This collated contribution is an opportunity to look back critically at what was advised then, and what has actually come to pass through Island Studies Journal. Russell King’s prescient report from 1991 is followed by a series of candid reflections by members of ISJ’s International Editorial Board.

  15. Assessing internet addiction using the parsimonious internet addiction components model—A preliminary study.

    OpenAIRE

    Kuss, D.J.; Shorter, G. W.; Rooij, A.J. van; Griffiths, M.D.; Schoenmakers, T.M.

    2014-01-01

    Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (Journal ...

  16. Assessing Internet addiction using the parsimonious Internet addiction components model - a preliminary study [forthcoming

    OpenAIRE

    Kuss, DJ; Shorter, GW; Van Rooij, AJ; Griffiths, MD; Schoenmakers, T.

    2014-01-01

    Internet usage has grown exponentially over the last decade. Research indicates that excessive Internet use can lead to symptoms associated with addiction. To date, assessment of potential Internet addiction has varied regarding populations studied and instruments used, making reliable prevalence estimations difficult. To overcome the present problems a preliminary study was conducted testing a parsimonious Internet addiction components model based on Griffiths’ addiction components (2005), i...

  17. Preliminary study of malaria incidence in Nouakchott, Mauritania.

    Science.gov (United States)

    Lekweiry, Khadijetou Mint; Abdallahi, Mohamed Ould; Ba, Hâmpaté; Arnathau, Céline; Durand, Patrick; Trape, Jean-François; Salem, Ali Ould Mohamed

    2009-05-05

    Malaria is one of the main motives for outpatient consultation and hospitalization in Mauritania. However, its incidence remains unclear because of diagnostic problems and insufficient epidemiological data. Between April and August 2007, a study on malaria incidence was carried out in Nouakchott city. A total of 237 febrile outpatients, from all Nouakchott districts, attending the two main hospitals of the city were investigated. Finger prick and blood dried filter paper samples were performed to prepare thick and thin films and nested-PCR for malaria parasite species identification and density. The accuracy of diagnosis of 'presumptive malaria', assigned by clinicians and based on fever and other malaria suggestive symptoms, was assessed. Entomological investigations based on morphological and molecular characterization of Anopheline species were conducted in Dar Naïm district. Malaria prevalence rate was 25.7% (61/237), the majority of positive blood slides as well as nested-PCR products were due to Plasmodium vivax 70.5% (43/61) and Plasmodium ovale 24.6% (15/61). Two malaria patients, both with P. vivax, have never travelled out of Nouakchott and seem likely to have been autochthonous (3.3%). Of the 237 individuals included in the survey, 231(97.5%) were clinically diagnosed and treated as malaria cases. 26.4% of clinically diagnosed cases were positive for Plasmodium using microscopic examination and PCR. Thus, false positive cases constituted 73.6% (170/231) of the clinically diagnosed malaria cases. The search for mosquito vectors in Dar Naïm district allowed morphological and molecular identification of Anopheles arabiensis and Anopheles pharoensis. This study demonstrates that, during the hot and dry season, Plasmodium species responsible of recurrent malaria (P. vivax and P. ovale) are the dominant species in Nouakchott city and autochthonous malaria cases exist but are rare. Clinical diagnosis of malaria has a very low positive predicted value. The

  18. Preliminary study of malaria incidence in Nouakchott, Mauritania

    Directory of Open Access Journals (Sweden)

    Trape Jean-François

    2009-05-01

    Full Text Available Abstract Background Malaria is one of the main motives for outpatient consultation and hospitalization in Mauritania. However, its incidence remains unclear because of diagnostic problems and insufficient epidemiological data. Methods Between April and August 2007, a study on malaria incidence was carried out in Nouakchott city. A total of 237 febrile outpatients, from all Nouakchott districts, attending the two main hospitals of the city were investigated. Finger prick and blood dried filter paper samples were performed to prepare thick and thin films and nested-PCR for malaria parasite species identification and density. The accuracy of diagnosis of 'presumptive malaria', assigned by clinicians and based on fever and other malaria suggestive symptoms, was assessed. Entomological investigations based on morphological and molecular characterization of Anopheline species were conducted in Dar Naïm district. Results Malaria prevalence rate was 25.7% (61/237, the majority of positive blood slides as well as nested-PCR products were due to Plasmodium vivax 70.5% (43/61 and Plasmodium ovale 24.6% (15/61. Two malaria patients, both with P. vivax, have never travelled out of Nouakchott and seem likely to have been autochthonous (3.3%. Of the 237 individuals included in the survey, 231(97.5% were clinically diagnosed and treated as malaria cases. 26.4% of clinically diagnosed cases were positive for Plasmodium using microscopic examination and PCR. Thus, false positive cases constituted 73.6% (170/231 of the clinically diagnosed malaria cases. The search for mosquito vectors in Dar Naïm district allowed morphological and molecular identification of Anopheles arabiensis and Anopheles pharoensis. Conclusion This study demonstrates that, during the hot and dry season, Plasmodium species responsible of recurrent malaria (P. vivax and P. ovale are the dominant species in Nouakchott city and autochthonous malaria cases exist but are rare. Clinical diagnosis

  19. Preliminary Hydrogeologic Characterization Results from the Wallula Basalt Pilot Study

    Energy Technology Data Exchange (ETDEWEB)

    B.P. McGrail; E. C. Sullivan; F. A. Spane; D. H. Bacon; G. Hund; P. D. Thorne; C. J. Thompson; S. P. Reidel; F. S. Colwell

    2009-12-01

    The DOE's Big Sky Regional Carbon Sequestration Partnership has completed drilling the first continental flood basalt sequestration pilot borehole to a total depth (TD) of 4,110 feet on the Boise White Paper Mill property at Wallula, Washington. Site suitability was assessed prior to drilling by the 2007-2008 acquisition, processing and analysis of a four-mile, five-line three component seismic swath, which was processed as a single data-dense line. Analysis of the seismic survey data indicated a composite basalt formation thickness of {approx}8,000 feet and absence of major geologic structures (i.e., faults) along the line imaged by the seismic swath. Drilling of Wallula pilot borehole was initiated on January 13, 2009 and reached TD on April 6, 2009. Based on characterization results obtained during drilling, three basalt breccia zones were identified between the depth interval of 2,716 and 2,910 feet, as being suitable injection reservoir for a subsequent CO2 injection pilot study. The targeted injection reservoir lies stratigraphically below the massive Umtanum Member of the Grande Ronde Basalt, whose flow-interior section possesses regionally recognized low-permeability characteristics. The identified composite injection zone reservoir provides a unique and attractive opportunity to scientifically study the reservoir behavior of three inter-connected reservoir intervals below primary and secondary caprock confining zones. Drill cuttings, wireline geophysical logs, and 31one-inch diameter rotary sidewall cores provided geologic data for characterization of rock properties. XRF analyses of selected rock samples provided geochemical characterizations of the rocks and stratigraphic control for the basalt flows encountered by the Wallula pilot borehole. Based on the geochemical results, the pilot borehole was terminated in the Wapshilla Ridge 1 flow of the Grande Ronde Basalt Formation. Detailed hydrologic test characterizations of 12 basalt interflow

  20. Clinoptilolite for Treatment of Dyslipidemia: Preliminary Efficacy Study.

    Science.gov (United States)

    Cutovic, Milisav; Lazovic, Milica; Vukovic-Dejanovic, Vesna; Nikolic, Dejan; Petronic-Markovic, Ivana; Cirovic, Dragana

    2017-09-01

    A tribomechanically activated clinoptilolite (natural aluminosilicate mineral) has been used to increase growth in meat-producing animals, as an adjuvant in cancer therapy, and a heavy metal remover in humans. Because of its unique cation exchanging and chelating properties, we hypothesized that clinoptilolite may be beneficial for the treatment of dyslipidemia in the manner similar to bile acid sequestrants. Thus, specific aims of this pilot study were to orally administer clinoptilolite in different doses and granule size combinations to determine magnitude and time profile of changes in blood lipids. A phase I/IIa prospective, open-label, uncontrolled, dose/granule size-ranging study (treatment phase 8 weeks, follow-up 6 weeks). Blood lipids were examined every 2 weeks. Outpatient clinic of a university-affiliated hospital. Forty-one subjects (all white, mean age 57.6 ± 6.8 years, 17 women) with blood lipids above the normative limits divided into three groups. A tribomechanically activated clinoptilolite was administered in three dose/grind combinations: 6 g/day of fine grind (6gF), 6 g/day of coarse grind (6gC), and 9 g/day of coarse grind (9gC). Blood concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc), and triglycerides (TG). For the 3 groups combined, all lipid fractions significantly improved after 8 weeks of treatment (20-25%, p < 0.001), which reversed to baseline after 6 weeks of clinoptilolite withdrawal. Early (week 2) and the most pronounced decrease in TC and LDLc was observed in the 6gF group (19% and 23% in week 8, respectively), with no difference in HDLc and TG between the three dose/grind groups. No side effects were reported. These pilot results suggest that oral administration of clinoptilolite may improve lipid profile in individuals with dyslipidemia, which warrants further investigations.

  1. A study of the safety of tenoxicam in general practice.

    Science.gov (United States)

    Caughey, D; Waterworth, R F

    1989-11-08

    An open, noncomparative study was undertaken to examine the safety of tenoxicam, a new nonsteroidal antiinflammatory drug (NSAID) in general practice. One thousand two hundred and sixty-seven patients with rheumatic conditions were recruited by 392 general practitioners throughout New Zealand. Forty-three point six percent of patients recruited were over 65 years of age, 62.5% had some form of concomitant disease and 76.3% of patients were already receiving NSAIDs. Three hundred and four (23.9%) patients experienced adverse drug reactions, the commonest being gastrointestinal (11.4%), central and peripheral nervous system disorders (2.8%) and skin reactions (2.5%). The profile of adverse drug reactions in those more than 65 was similar to those in patients under 65 years. Of the reactions reported, 14.7% were considered severe. Three peptic ulcers were reported. There were no unexpected adverse drug reactions. Eight hundred and forty-nine patients completed 6 months treatment. Subjective assessments of overall efficacy, pain at night, pain on movement and stiffness made before treatment and at 1, 3 and 6 months posttreatment showed that tenoxicam significantly improved all parameters. The clinical response was maintained throughout the 6 month study period and was not different in patients less than or greater than 65 years.

  2. Food safety and older people: the Kitchen Life study.

    Science.gov (United States)

    Dickinson, Angela; Wills, Wendy; Meah, Angela; Short, Frances

    2014-05-01

    Foodborne illness (FBI) is a major public health problem in the UK. Recent increases in cases of listeriosis in older people have focused attention on consumer food-related practices. Previous studies highlight poor relationships between what people know, what they say they do and what they actually do in the kitchen. The aim of the Kitchen Life study was to examine what actually happens in the domestic kitchen to assess whether and how this has the potential to influence food safety in the home. Drawing on a qualitative ethnographic approach, methods included a kitchen tour, photography, observation, video observation, informal interviews and diary methods. Ten households with older people (aged 60+) were recruited across the UK. It was found that trust in the food supply, use of food-labelling (including use-by dates), sensory logics (such as the feel or smell of food) and food waste were factors with the potential to influence risk of foodborne illness. Practices shifted with changing circumstances, including increased frailty, bereavement, living alone, receiving help with care and acquiring new knowledge, meaning that the risk of and vulnerability to foodborne illness is not straightforward.

  3. Robotic consolle for ocular surgery: a preliminary study

    Science.gov (United States)

    Rossi, Francesca; Pini, Roberto; Menabuoni, Luca; Lenzetti, Ivo; Russo, Sheila; Menciassi, Arianna; Fortuna, Damiano

    2014-02-01

    Minimally invasive surgery has recently been improved by the use of robot-assisted procedures in several medical fields. Among the ocular surgeries there are a few examples of sophisticated vitreoretinal procedures, while robotic-assisted surgery of the anterior eye segment is still under study. In this paper we propose a new approach to the robotic assisted ocular surgery: a CO2 laser system is equipped with a micromanipulator and scanner, and it is proposed to induce photothermal effects for the removal of neoformations. A sensorized tool is connected to the patient eye and to the robotic arm. This tool is equipped with force and position sensors: by the use of the spatial information from the robotic console and from the patient it is possible to control the position of the target itself and to block it in the correct position for performing surgery. The system is provided by a feedback alarm that remove the block of the patient head in any moment. The optimized robotic consolle can be used in performing scleral cuts and in the treatment of pterigium or neoformations.

  4. Preliminary studies on hoof characteristics in Amiata donkey

    Directory of Open Access Journals (Sweden)

    Alessandro Giorgetti

    2012-01-01

    Full Text Available In this work the biometrical, physical and chemical characteristics of Amiata donkey hoof were studied. The Amiata donkey is a local endangered breed and derives from the homonym mountain in Tuscany. This donkey, which was once used as pack animal in farms and in mines, is now involved in trekking, onotherapy and milk production. The mean hoof biometrics and its standard deviation were calculated. The physical and chemical characteristics were also estimated, through ANOVA, considering the hoof region as fixed effect: wall, white line and sole for hardness, wall and sole for chemical characteristics. The small size and healthy hoof, was basically cylindrical (crown cir./Foot plantar circ. ratio=0.9 and it showed higher hardness in wall (H=126.5± 3.3, followed by sole (H=105.2±3.3, and white line (H=74.0±3.3. The wall has shown the lower moisture content (%=11.7±3.2 and the higher content in Al, Mn, Li, Ni, Pb, Se. The positive correlation between Al, Li, Pb and Hardness has shown the hoof high resistence to toxic elements. Very interesting has seemed the negative correlation between K vs Li and Pb, to indicate the tendency of K to remove potentially harmful elements.

  5. PRELIMINARY STUDIES OF RIVETED JOINTS AT FEED FORCE

    Directory of Open Access Journals (Sweden)

    Radosław Bielawski

    2015-08-01

    Full Text Available The aim of the study was to determine the feasibility of riveted joints in composites materials. Static tensile test method was used. In the test one type of glass fabric was used (Interglas 92140 from which two types of composite samples were prepared. In each sample the same type of fiber with the same fiber orientation – 3 layers - was used. The samples had dimensions of 100×100 mm and thickness of approximately 1 mm. The composite probes were located in a metal frame with a screw connection which was made of screws with nominal thread pitch M5. Screws were tightened with constant torque. It was to provide an axial force to the sample during the tensile test. The frame was placed between cross-bars of tensile machine INSTRON 8516. The samples were stretched at a speed of 0.05 mm/s at a distance up to 16 mm. During the tensile test displacement of the samples and pull force were registered. Depending on the fibre orientations and the value of feed force, damage models were described. On the basis of the results the possibility of usage of aluminium rivet nuts connections in composite materials was determined.

  6. A preliminary study on dead geostationary satellite removal

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The collision between satellites IRIDIUM 33 and COSMOS 2251 indicated that the clash of two on-orbit satellites was becoming an inevitable reality. Our calculation with the two-line orbit element by NORAD showed that some two geostationary satellites had approached very close in July 2009. Therefore, more attention should be given to avoid such collisions. This paper analyzes the orbital long-term variation of a dead satellite drifting in the geostationary orbit. Also, the negative effects posed by dead satellites upon the on-orbit operational geostationary satellites are studied. Then the paper proposes a novel idea to launch a satellite sweeper whose purpose is to collect the on-orbit dead satellites and help them de-orbit to a "graveyard". The satellite sweeper consists of a parent satellite and a child satellite. The child satellite collects a dead satellite and transfers it to a higher orbit. The parent satellite stationed in the geostationary orbit is in charge of refueling the child satellite. The strategy of maneuver and rendezvous is presented and a series of formulas are derived. The analysis results show that our method to clean the geostationary orbital zone is practical and fuel-saving. With the help of just a few satellite sweepers, we can gain a clean environment of geostationary orbit environment again.

  7. Preliminary Study for Designing a Novel Vein-Visualizing Device

    Directory of Open Access Journals (Sweden)

    Donghoon Kim

    2017-02-01

    Full Text Available Venipuncture is an important health diagnosis process. Although venipuncture is one of the most commonly performed procedures in medical environments, locating the veins of infants, obese, anemic, or colored patients is still an arduous task even for skilled practitioners. To solve this problem, several devices using infrared light have recently become commercially available. However, such devices for venipuncture share a common drawback, especially when visualizing deep veins or veins of a thick part of the body like the cubital fossa. This paper proposes a new vein-visualizing device applying a new penetration method using near-infrared (NIR light. The light module is attached directly on to the declared area of the skin. Then, NIR beam is rayed from two sides of the light module to the vein with a specific angle. This gives a penetration effect. In addition, through an image processing procedure, the vein structure is enhanced to show it more accurately. Through a phantom study, the most effective penetration angle of the NIR module is decided. Additionally, the feasibility of the device is verified through experiments in vivo. The prototype allows us to visualize the vein patterns of thicker body parts, such as arms.

  8. Preliminary Study for Designing a Novel Vein-Visualizing Device.

    Science.gov (United States)

    Kim, Donghoon; Kim, Yujin; Yoon, Siyeop; Lee, Deukhee

    2017-02-07

    Venipuncture is an important health diagnosis process. Although venipuncture is one of the most commonly performed procedures in medical environments, locating the veins of infants, obese, anemic, or colored patients is still an arduous task even for skilled practitioners. To solve this problem, several devices using infrared light have recently become commercially available. However, such devices for venipuncture share a common drawback, especially when visualizing deep veins or veins of a thick part of the body like the cubital fossa. This paper proposes a new vein-visualizing device applying a new penetration method using near-infrared (NIR) light. The light module is attached directly on to the declared area of the skin. Then, NIR beam is rayed from two sides of the light module to the vein with a specific angle. This gives a penetration effect. In addition, through an image processing procedure, the vein structure is enhanced to show it more accurately. Through a phantom study, the most effective penetration angle of the NIR module is decided. Additionally, the feasibility of the device is verified through experiments in vivo. The prototype allows us to visualize the vein patterns of thicker body parts, such as arms.

  9. Health impacts of garage workers: A preliminary study

    Energy Technology Data Exchange (ETDEWEB)

    Muttamara, S. (AIT, Bangkok (Thailand). Division of Environmental Engineering); Alwis, K.U.

    1994-05-01

    This research study was carried out in two automobile repair garages situated in the Bangkok metropolitan area, employing 47 and 12 workers respectively. Air sampling, biological monitoring (blood, urine), noise monitoring, and audiometry of workers were done to assess the occupational environment and its impact on the workers. The occupational hygiene survey was carried out to observe the working conditions of both garages. It was found that conditions at both sites have a strong negative impact on the health of workers. The lead in air of Garage 1 was 0.20 mg/m[sup 3] which is the same as the threshold limit value (TLV) for lead in air for a working environment. The level of lead in blood of four workers of each garage was above the exposed level. According to the occupational hygiene survey carried out at both garages, 79% of workers of Garage 1 and 70% of workers of Gage 2 suffered from redness of the eyes (eye pain, gritty feeling), and 5% and 2% of workers of Garage 1 and Garage 2 respectively, complained about breathing difficulties. Control measures should be taken to minimize pollution due to dust, fumes, and noise which would reduce the health impacts and lead to a healthier workforce.

  10. Preliminary studies on affirmative action in a brazilian university1

    Directory of Open Access Journals (Sweden)

    Eduardo de São Paulo

    2010-06-01

    Full Text Available As a signatory to Durban III World Conference against Racism, Discrimination, Xenophobia and other forms of Intolerance, Brazil has committed itself to the enforcement of mechanisms to promote social equity. As a consequence, governmental programs have been implemented, aiming at the inclusion of Afrodescendents h students in the academy is minimal and does not relate to what can be observed in the general population. As an example of such endeavor, Universidade de Brasília (UnB has started an Affirmative Action program in order to include a contingent of 20% of its freshman students as representatives of racial underprivileged groups. This policy started in August 2004. The present study aimed to investigate the perceptions of students and general public to this policy. An instrument, based partially on McConahay´s (1986 Modern Racism scale, was administered to a sample of 316 students. A factor analysis (AF extracted five factors, corresponding to 48% of the total variance explained. An Analysis of Variance (Anova was performed to better understand the results, concerning both age and gender of the subjects. Results show that, although students demonstrated interest in the implementing of Affirmative Action programs, and are aware of the relevance of such procedures to the cultural and social structure of the community, they do not agree with their reasons or measures taken, or to the existence of the problem itself.

  11. A preliminary study on drought events in Peninsular Malaysia

    Science.gov (United States)

    Zin, Wan Zawiah Wan; Nahrawi, Siti Aishah; Jemain, Abdul Aziz; Zahari, Marina

    2014-06-01

    In this research, the Standard Precipitation Index (SPI) is used to represent the dry condition in Peninsular Malaysia. To do this, data of monthly rainfall from 75 stations in Peninsular Malaysia is used to obtain the SPI values at scale one. From the SPI values, two drought characteristics that are commonly used to represent the dry condition in an area that is the duration and severity of a drought period are identified and their respective values calculated for every station. Spatial mappings are then used to identify areas which are more likely to be affected by longer and more severe drought condition from the results. As the two drought characteristics may be correlated with each other, the joint distribution of severity and duration of dry condition is considered. Bivariate copula model is used and five copula models were tested, namely, the Gumbel-Hougard, Clayton, Frank, Joe and Galambos copulas. The copula model, which best represents the relationship between severity and duration, is determined using Akaike information criterion. The results showed that the Joe and Clayton copulas are well-fitted by close to 60% of the stations under study. Based on the results on the most appropriate copula-based joint distribution for each station, some bivariate probabilistic properties of droughts can then be calculated, which will be continued in future research.

  12. The meanings of delusions in dementia: a preliminary study.

    Science.gov (United States)

    Cohen-Mansfield, Jiska; Golander, Hava; Ben-Israel, Joshua; Garfinkel, Doron

    2011-08-30

    One of the common symptoms of dementia is delusions. Due to a biological conceptualization of the behaviors represented as delusions, these are classified as psychotic symptoms. This is a qualitative and quantitative study aiming to describe the delusions experienced by older persons with dementia and the context of occurrence, and to elucidate their etiology. Participants were 74 nursing home residents aged 65 and over, diagnosed with dementia, from nine nursing homes in Israel. Participants with delusions were found to have significantly more difficulties in performing ADLs, and poorer vision and hearing. Based on assessment using the BEHAVE-AD, six categories of delusions were examined: 1. One's house is not one's home, 2. Theft, 3. Danger, 4. Abandonment, 5. Misidentification, and 6. Other non-paranoid. Common themes appeared across delusions including reality, disorientation, re-experience of past events, loneliness and insecurity, boredom, and trigger. Current results suggest that delusions may not represent psychotic symptoms for most participants, because they sometimes represented reality, or were neither firm nor incontrovertible. Thus, utilizing the term delusion relegates the person's behavior to the domain of severe psychiatric phenomena and precludes understanding its true meaning. Copyright © 2011. Published by Elsevier Ireland Ltd.

  13. An automatic tooth preparation technique: A preliminary study

    Science.gov (United States)

    Yuan, Fusong; Wang, Yong; Zhang, Yaopeng; Sun, Yuchun; Wang, Dangxiao; Lyu, Peijun

    2016-04-01

    The aim of this study is to validate the feasibility and accuracy of a new automatic tooth preparation technique in dental healthcare. An automatic tooth preparation robotic device with three-dimensional motion planning software was developed, which controlled an ultra-short pulse laser (USPL) beam (wavelength 1,064 nm, pulse width 15 ps, output power 30 W, and repeat frequency rate 100 kHz) to complete the tooth preparation process. A total of 15 freshly extracted human intact first molars were collected and fixed into a phantom head, and the target preparation shapes of these molars were designed using customised computer-aided design (CAD) software. The accuracy of tooth preparation was evaluated using the Geomagic Studio and Imageware software, and the preparing time of each tooth was recorded. Compared with the target preparation shape, the average shape error of the 15 prepared molars was 0.05–0.17 mm, the preparation depth error of the occlusal surface was approximately 0.097 mm, and the error of the convergence angle was approximately 1.0°. The average preparation time was 17 minutes. These results validated the accuracy and feasibility of the automatic tooth preparation technique.

  14. NEOWISE Studies of Asteroids with Sloan Photometry: Preliminary Results

    CERN Document Server

    Mainzer, A; Grav, T; Bauer, J; Tholen, D J; McMillan, R S; Wright, E; Spahr, T; Cutri, R M; Walker, R; Mo, W; Watkins, J; Hand, E; Maleszewski, C

    2011-01-01

    We have combined the NEOWISE and Sloan Digital Sky Survey data to study the albedos of 24,353 asteroids with candidate taxonomic classifications derived using Sloan photometry. We find a wide range of moderate to high albedos for candidate S-type asteroids that are analogous to the S-complex defined by previous spectrophotometrically-based taxonomic systems. The candidate C-type asteroids, while generally very dark, have a tail of higher albedos that overlaps the S types. The albedo distribution for asteroids with a photometrically derived Q classification is extremely similar to those of the S types. Asteroids with similar colors to (4) Vesta have higher albedos than the S types, and most have orbital elements similar to known Vesta family members. Finally, we show that the relative reflectance at 3.4 and 4.6 $\\mu$m is higher for D-type asteroids and suggest that their red visible and near-infrared spectral slope extends out to these wavelengths. Understanding the relationship between size, albedo, and taxon...

  15. Preliminary study of synergism of acid rain and diflubenzuron

    Energy Technology Data Exchange (ETDEWEB)

    Martin, P.J.S.; Clark, J.M.; Edman, J.D. [Univ. of Massachusetts, Amherst (United States)

    1995-06-01

    Diflubenzuron{sup 1} (Dimilin{reg_sign}) was used on over 7 million acres in the U.S. in 1990 to control forest pests, particularly the gypsy moth. This chitin synthesis inhibitor affects insects and other anthropods. It is a restricted use pesticide due to its nontarget effects on aquatic macroinvertebrates. The effects of a single aerial application on nontarget aquatic macroinvertebrate communities were reviewed by Eisler (1992). Crustacea and immature insects (especially the true flies, mosquitoes, midges and black flies) are the most sensitive nontarget aquatic organisms to diflubenzuron. Diflubenzuron, N-[[4-(chlorophenyl)amino]carbonyl]-2,6-difluorobenzamide, is not the only mortality factor aquatic organisms face from human pollution. Acid deposition is a frequent stress factor in freshwater habitats in the Northeast USA. Acidic pulses can drop vernal pools (e.g., temporary, springtime, snowmelt pools) to pH levels below 3.0. Aquatic invertebrates vary in their tolerance to acidification. Reduced pH completely eliminates some species. A combination of stress factors could lead to synergistic effects, over and above the impact seen with a single stressor. The purpose of this study was to determine if there are synergist effects of diflubenzuron and lowered pH on the mortality of a nontarget aquatic organism. 11 refs., 1 fig.

  16. A Preliminary Study of Active Region Canopies With AIA

    Science.gov (United States)

    Lucchini, Scott; Saar, S.; Muglach, K.

    2013-01-01

    Active region canopies are areas frequently accompanying active regions which have extensive horizontal magnetic fields. The large-scale canopy fields have a significant effect on the kinds of structures which can exist beneath them, and how they evolve. Using data from the Atmospheric Imaging Assembly (AIA), we developed methods to automatically identify these regions. A Differential Emission Measure (DEM) analysis is consistent with the idea that the long, hotter active region loops overlie quite cool, small-scale features ("fibrils"). We suggest that the overlying loops restrict the growth of underlying structures to mostly very short, cool features. We also studied evolution of canopy regions over time. In several cases, a large quiescent filament formed out of the former canopy region over the course of a few solar rotations, confirming previous suggestions. The canopy remains visible for several rotations after its active regions have begun to decay; in this time, the fibril magnetic fields gradually align in such a way as to form a filament channel. Further analysis of our large canopy database should uncover more information on the frequency and characteristics of these canopy-to-filament evolutions, as well as other canopy properties. This work is supported by the NSF REU program at SAO (grant ATM-0851866) and contract SP02H1701R from Lockheed Martin to SAO for SDO research.

  17. Social network analysis in identifying influential webloggers: A preliminary study

    Science.gov (United States)

    Hasmuni, Noraini; Sulaiman, Nor Intan Saniah; Zaibidi, Nerda Zura

    2014-12-01

    In recent years, second generation of internet-based services such as weblog has become an effective communication tool to publish information on the Web. Weblogs have unique characteristics that deserve users' attention. Some of webloggers have seen weblogs as appropriate medium to initiate and expand business. These webloggers or also known as direct profit-oriented webloggers (DPOWs) communicate and share knowledge with each other through social interaction. However, survivability is the main issue among DPOW. Frequent communication with influential webloggers is one of the way to keep survive as DPOW. This paper aims to understand the network structure and identify influential webloggers within the network. Proper understanding of the network structure can assist us in knowing how the information is exchanged among members and enhance survivability among DPOW. 30 DPOW were involved in this study. Degree centrality and betweenness centrality measurement in Social Network Analysis (SNA) were used to examine the strength relation and identify influential webloggers within the network. Thus, webloggers with the highest value of these measurements are considered as the most influential webloggers in the network.

  18. Preliminary Study for Designing a Novel Vein-Visualizing Device

    Science.gov (United States)

    Kim, Donghoon; Kim, Yujin; Yoon, Siyeop; Lee, Deukhee

    2017-01-01

    Venipuncture is an important health diagnosis process. Although venipuncture is one of the most commonly performed procedures in medical environments, locating the veins of infants, obese, anemic, or colored patients is still an arduous task even for skilled practitioners. To solve this problem, several devices using infrared light have recently become commercially available. However, such devices for venipuncture share a common drawback, especially when visualizing deep veins or veins of a thick part of the body like the cubital fossa. This paper proposes a new vein-visualizing device applying a new penetration method using near-infrared (NIR) light. The light module is attached directly on to the declared area of the skin. Then, NIR beam is rayed from two sides of the light module to the vein with a specific angle. This gives a penetration effect. In addition, through an image processing procedure, the vein structure is enhanced to show it more accurately. Through a phantom study, the most effective penetration angle of the NIR module is decided. Additionally, the feasibility of the device is verified through experiments in vivo. The prototype allows us to visualize the vein patterns of thicker body parts, such as arms. PMID:28178227

  19. Procurement challenges in the Zimbabwean public sector: A preliminary study

    Directory of Open Access Journals (Sweden)

    Abel Dzuke

    2015-02-01

    Full Text Available Background: State Procurement Board procedures and the public procurement process have been blamed for the lagging behind of government projects that impact on public service delivery in Zimbabwe.Objectives: This article provides insight into challenges resulting from the legal framework for public procurement in Zimbabwe that detract from service delivery.Method: Empirical data was collected through in-depth interviews with five participants at five public entities, using a semi-structured interview guide. Content analysis was used to analyse the primary data.Results: The findings revealed various challenges in the public procurement process that detract from service delivery. These include a lack of strategic recognition of the procurement function and procurement policy; a lack of professional, managerial and leadership skills; a lack of appropriated funds from Treasury; and a lack of accountability in the procurement process.Conclusion: There is a dearth of research on the public procurement process and its efficiency in Zimbabwe, and this study contributes to the existing body of knowledge by identifying areas through which public procurement can be improved in Zimbabwe.

  20. Risk of caries and oral health: preliminary study

    Directory of Open Access Journals (Sweden)

    Marcello Gatti

    2009-12-01

    Full Text Available Introduction. The incidence of injury cariosa remains high, despite the improvements achieved in the last years. Recent national epidemiological surveys, 4 years old children have healthy teeth in 80% of cases at 12 years the percentage is reduced to 50%. In Italy, the almost total absence on the territory of “dental services to the Community”, makes even more difficult to achieve a solution to the problem “caries.” To address this problem, the Ministry of Labor, Health and Social Policy in October 2008 adopted the national guidelines in order to make suggestions to the various professionals (pediatricians, dentists, microbiologists, dental hygienists, etc., making them interact to maintain and restore oral health. It was the first time that the Ministry of Health has addressed the problem by inserting the figure of the microbiologist in dentistry. Aims. The present study aim was to identify subjects at risk of caries by clinical microbiological testing of saliva and the index DMFT/dmft (Decayed, Missing and Filling Permanent Teeth in both adults and particularly children in order to take preventive measures early as reported in “National guidelines for the promotion of oral health and prevention of oral diseases in age of development”. The study began in June 2009 and will last one year with as goal to have, in 2010, 90% of children between 5 and 6 years caries free and 18 years with any lost tooth decay. Materials and methods. Recruited 164 patients were divided into three age groups: 124 adults aged between 20 and 40 years, 40 children which 21 till 5 years old and 19 till 12 years old. Microbiological testing was aimed by finding CFU / ml of saliva of Streptococcus mutans and Lactobacillus spp., Slide CRT bacteria (Ivoclar. Clinically, intraoral examination was performed to evaluate the DMFT (Decayed teeth, Missing or Filling calculated over 28 permanent teeth and the dmft (decayed teeth, missing or filling calculated on 20