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Sample records for preirradiation control levels

  1. Inhibition of IL-17A suppresses enhanced-tumor growth in low dose pre-irradiated tumor beds.

    Directory of Open Access Journals (Sweden)

    Eun-Jung Lee

    Full Text Available Ionizing radiation induces modification of the tumor microenvironment such as tumor surrounding region, which is relevant to treatment outcome after radiotherapy. In this study, the effects of pre-irradiated tumor beds on the growth of subsequently implanted tumors were investigated as well as underlying mechanism. The experimental model was set up by irradiating the right thighs of C3H/HeN mice with 5 Gy, followed by the implantation of HCa-I and MIH-2. Both implanted tumors in the pre-irradiated bed showed accelerated-growth compared to the control. Tumor-infiltrated lymphocyte (TIL levels were increased, as well as pro-tumor factors such as IL-6 and transforming growth factor-beta1 (TGF-β1 in the pre-irradiated group. In particular, the role of pro-tumor cytokine interleukin-17A (IL-17A was investigated as a possible target mechanism because IL-6 and TGF-β are key factors in Th17 cells differentiation from naïve T cells. IL-17A expression was increased not only in tumors, but also in CD4+ T cells isolated from the tumor draining lymph nodes. The effect of IL-17A on tumor growth was confirmed by treating tumors with IL-17A antibody, which abolished the acceleration of tumor growth. These results indicate that the upregulation of IL-17A seems to be a key factor for enhancing tumor growth in pre-irradiated tumor beds.

  2. AGC-2 Graphite Preirradiation Data Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    William Windes; W. David Swank; David Rohrbaugh; Joseph Lord

    2013-08-01

    This report described the specimen loading order and documents all pre-irradiation examination material property measurement data for the graphite specimens contained within the second Advanced Graphite Capsule (AGC-2) irradiation capsule. The AGC-2 capsule is the second in six planned irradiation capsules comprising the Advanced Graphite Creep (AGC) test series. The AGC test series is used to irradiate graphite specimens allowing quantitative data necessary for predicting the irradiation behavior and operating performance of new nuclear graphite grades to be generated which will ascertain the in-service behavior of the graphite for pebble bed and prismatic Very High Temperature Reactor (VHTR) designs. Similar to the AGC-1 specimen pre-irradiation examination report, material property tests were conducted on specimens from 18 nuclear graphite types but on an increased number of specimens (512) prior to loading into the AGC-2 irradiation assembly. All AGC-2 specimen testing was conducted at Idaho National Laboratory (INL) from October 2009 to August 2010. This report also details the specimen loading methodology for the graphite specimens inside the AGC-2 irradiation capsule. The AGC-2 capsule design requires “matched pair” creep specimens that have similar dose levels above and below the neutron flux profile mid-plane to provide similar specimens with and without an applied load. This document utilized the neutron flux profile calculated for the AGC-2 capsule design, the capsule dimensions, and the size (length) of the selected graphite and silicon carbide samples to create a stacking order that can produce “matched pairs” of graphite samples above and below the AGC-2 capsule elevation mid-point to provide specimens with similar neutron dose levels.

  3. AGC-3 Graphite Preirradiation Data Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    William Windes; David Swank; David Rohrbaugh; Joseph Lord

    2013-09-01

    This report describes the specimen loading order and documents all pre-irradiation examination material property measurement data for the graphite specimens contained within the third Advanced Graphite Capsule (AGC-3) irradiation capsule. The AGC-3 capsule is third in six planned irradiation capsules comprising the Advanced Graphite Creep (AGC) test series. The AGC test series is used to irradiate graphite specimens allowing quantitative data necessary for predicting the irradiation behavior and operating performance of new nuclear graphite grades to be generated which will ascertain the in-service behavior of the graphite for pebble bed and prismatic Very High Temperature Reactor (VHTR) designs. The general design of AGC-3 test capsule is similar to the AGC-2 test capsule, material property tests were conducted on graphite specimens prior to loading into the AGC-3 irradiation assembly. However the 6 major nuclear graphite grades in AGC-2 were modified; two previous graphite grades (IG-430 and H-451) were eliminated and one was added (Mersen’s 2114 was added). Specimen testing from three graphite grades (PCEA, 2114, and NBG-17) was conducted at Idaho National Laboratory (INL) and specimen testing for two grades (IG-110 and NBG-18) were conducted at Oak Ridge National Laboratory (ORNL) from May 2011 to July 2013. This report also details the specimen loading methodology for the graphite specimens inside the AGC-3 irradiation capsule. The AGC-3 capsule design requires "matched pair" creep specimens that have similar dose levels above and below the neutron flux profile mid-plane to provide similar specimens with and without an applied load. This document utilized the neutron flux profile calculated for the AGC-3 capsule design, the capsule dimensions, and the size (length) of the selected graphite and silicon carbide samples to create a stacking order that can produce "matched pairs" of graphite samples above and below the AGC-3 capsule elevation mid-point to

  4. Radicals contributing to preirradiation graft polymerization onto porous polyethylene

    Science.gov (United States)

    Uezu, Kazuya; Saito, Kyoichi; Furusaki, Shintaro; Sugo, Takanobu; Ishigaki, Isao

    Porous polyethylene hollow fiber was irradiated by an electron beam at 160 kGy and 8 kGy/min. The concentrations of the radicals such as alkyl, allyl and peroxy were determined by analyzing an integral form of ESR spectra. The comparison of the decay of the radicals with and without contact with air demonstrated that the key radical contributing to the preirradiation graft polymerization is the alkyl radical. The decay of the alkyl radical was simulated by the diffusion-controlled model in the spherical crystallites of polyethylene.

  5. AGC-2 Graphite Preirradiation Data Package

    Energy Technology Data Exchange (ETDEWEB)

    David Swank; Joseph Lord; David Rohrbaugh; William Windes

    2012-10-01

    The NGNP Graphite R&D program is currently establishing the safe operating envelope of graphite core components for a Very High Temperature Reactor (VHTR) design. The program is generating quantitative data necessary for predicting the behavior and operating performance of the new nuclear graphite grades. To determine the in-service behavior of the graphite for pebble bed and prismatic designs, the Advanced Graphite Creep (AGC) experiment is underway. This experiment is examining the properties and behavior of nuclear grade graphite over a large spectrum of temperatures, neutron fluences and compressive loads. Each experiment consists of over 400 graphite specimens that are characterized prior to irradiation and following irradiation. Six experiments are planned with the first, AGC-1, currently being irradiated in the Advanced Test Reactor (ATR) and pre-irradiation characterization of the second, AGC-2, completed. This data package establishes the readiness of 512 specimens for assembly into the AGC-2 capsule.

  6. Effect of disodium cromoglycate (DSCG) and antihistamines on post-irradiation cerebral blood flow and plasma levels of histamine and neurotensin

    Energy Technology Data Exchange (ETDEWEB)

    Cockerham, L.G.; Pautler, E.L.; Carraway, R.E.; Cochrane, D.E.; Hampton, J.D.

    1988-01-01

    In an attempt to elucidate mechanisms underlying the irradiation-induced decrease in regional cerebral blood flow (rCBF) in primates, hippocampal and visual cortical blood flows of rhesus monkeys were measured by hydrogen clearance, before and after exposure to 100-Gy, whole-body, gamma irradiation. Systemic blood pressures were monitored simultaneously. Systemic arterial plasma histamine and neurotensin levels were determined preirradiation and postirradiation. Compared to control animals, the irradiated monkeys exhibited an abrupt decline in systemic blood pressure to 23% of the preirradiation level within 10-min postirradiation, falling to 12% by 60 min. A decrease in hippocampal blood flow to 32% of the preirradiation level was noted at 10-min postirradiation, followed by a slight recovery to 43% at 30 min and a decline to 23% by 60 min. The cortical blood flow for the same animals showed a steady decrease to 29% of the preirradiation levels by 60-min postirradiation. Animals given the mast-cell stabilizer disodium cromoglycate and the antihistamines mepyramine and cimetidine before irradiation did not exhibit an abrupt decline in blood pressure but displayed a gradual decrease to a level 33% below preirradiation levels by 60 min postirradiation. Also, the treated, irradiated monkeys displayed rCBF values that were not significantly different from the nonirradiated controls. The plasma neurotensin levels in the irradiated animals, treated and untreated, indicated a nonsignificant postirradiation increase above control levels.

  7. Effect of disodium cromoglycate (DSCG) and antihistamines on postirradiation cerebral blood flow and plasma levels of histamine and neurotensin

    Energy Technology Data Exchange (ETDEWEB)

    Cockerham, L.G.; Pautler, E.L.; Carraway, R.E.; Cochrane, D.E.; Hampton, J.D.

    1988-02-01

    In an attempt to elucidate mechanisms underlying the irradiation-induced decrease in regional cerebral blood flow (rCBF) in primates, hippocampal and visual cortical blood flows of rhesus monkeys were measured by hydrogen clearance, before and after exposure to 100 Gy, whole-body, gamma irradiation. Systemic blood pressures were monitored simultaneously. Systemic arterial plasma histamine and neurotensin levels were determined preirradiation and postirradiation. Compared to control animals, the irradiated monkeys exhibited an abrupt decline in systemic blood pressure to 23% of the preirradiation level within 10 min postirradiation, falling to 12% by 60 min. A decrease in hippocampal blood flow to 32% of the preirradiation level was noted at 10 min postirradiation, followed by a slight recovery to 43% at 30 min and a decline to 23% by 60 min. The cortical blood flow for the same animals showed a steady decrease to 29% of the preirradiation levels by 60 min postirradiation. Animals given the mast cell stabilizer disodium cromoglycate and the antihistamines mepyramine and cimetidine before irradiation did not exhibit an abrupt decline in blood pressure but displayed a gradual decrease to a level 33% below preirradiation levels by 60 min postirradiation. Also, the treated, irradiated monkeys displayed rCBF values that were not significantly different from the nonirradiated controls. The plasma neurotensin levels in the irradiated animals, treated and untreated, indicated a nonsignificant postirradiation increase above control levels. However, the postirradiation plasma histamine levels in both irradiated groups showed an increase of approximately 1600% above the preirradiation levels and the postirradiation control levels.

  8. Influence of photo- and thermal bleaching on pre-irradiation low water peak single mode fibers

    Science.gov (United States)

    Yin, Jianchong; Wen, Jianxiang; Luo, Wenyun; Xiao, Zhongyin; Chen, Zhenyi; Wang, Tingyun

    2011-12-01

    Reducing the radiation-induced transmission loss in low water peak single mode fiber (LWP SMF) has been investigated by using photo-bleaching method with 980nm pump light source and using thermal-bleaching method with temperature control system. The results show that the radiation-induced loss of pre-irradiation optical fiber can be reduced effectively with the help of photo-bleaching or thermal-bleaching. Although the effort of photo-bleaching is not as significant as thermal-bleaching, by using photo-bleaching method, the loss of fiber caused by radiation-induced defects can be reduced best up to 49% at 1310nm and 28% at 1550nm in low pre-irradiation condition, the coating of the fiber are not destroyed, and the rehabilitating time is just several hours, while self-annealing usually costs months' time. What's more, the typical high power LASER for photo-bleaching can be 980nm pump Laser Diode, which is very accessible.

  9. Humidity Sensing Properties of Pre-irradiation Grafted HDPE Membranes

    Institute of Scientific and Technical Information of China (English)

    Zheng Jiao; Qun Fu; Xiang Geng; Zhen Li; Haijian Zhong

    2006-01-01

    Grafted high density polyethylene (HDPE) films have been prepared by grafting sodium styrene sulfonate (SSS) and acrylic acid (AA) onto HDPE using preirradiation method. The structure and surface morphology of both grafted and ungrafted HDPE films were observed by FTIR spectroscopy and scanning electron microscope (SEM), respectively. The humidity sensing properties of grafted HDPE films were investigated. The results show that the impedance of the film decreases with increasing of relative humidity (RH). The films display high sensitivity with nearly three orders of magnitude change in the resistance during the relative humidity variation from 5% to 98%. Grafted HDPE films exhibit excellent properties as humidity sensors.

  10. Effect of pre-irradiation with different doses, wavelengths, and application intervals of low-level laser therapy on cytochrome c oxidase activity in intact skeletal muscle of rats.

    Science.gov (United States)

    Albuquerque-Pontes, Gianna Móes; Vieira, Rodolfo de Paula; Tomazoni, Shaiane Silva; Caires, Cláudia Oliveira; Nemeth, Victoria; Vanin, Adriane Aver; Santos, Larissa Aline; Pinto, Henrique Dantas; Marcos, Rodrigo Labat; Bjordal, Jan Magnus; de Carvalho, Paulo de Tarso Camillo; Leal-Junior, Ernesto Cesar Pinto

    2015-01-01

    Modulation of cytochrome c oxidase activity has been pointed as a possible key mechanism for low-level laser therapy (LLLT) in unhealthy biological tissues. But recent studies by our research group with LLLT in healthy muscles before exercise found delayed skeletal muscle fatigue development and improved biochemical status in muscle tissue. Therefore, the aim of this study was to evaluate effects of different LLLT doses and wavelengths in cytochrome c oxidase activity in intact skeletal muscle. In this animal experiment, we irradiated the tibialis anterior muscle of rats with three different LLLT doses (1, 3, and 10 J) and wavelengths (660, 830, and 905 nm) with 50 mW power output. After irradiation, the analyses of cytochrome c oxidase expression by immunohistochemistry were analyzed at 5, 10, 30 min and at 1, 2, 12, and 24 h. Our results show that LLLT increased (p cytochrome c oxidase expression mainly with the following wavelengths and doses: 660 nm with 1 J, 830 nm with 3 J, and 905 nm with 1 J at all time points. We conclude that LLLT can increase cytochrome c oxidase activity in intact skeletal muscle and that it contributes to our understanding of how LLLT can enhance performance and protect skeletal muscles against fatigue development and tissue damage. Our findings also lead us to think that the combined use of different wavelengths at the same time can enhance LLLT effects in skeletal muscle performance and other conditions, and it can represent a therapeutic advantage in clinical settings.

  11. Meaning of pre-irradiation to diamond detector

    CERN Document Server

    Baba, S; Toyoda, T; Wakamatsu, O; Machida, T

    2002-01-01

    Diamond detector PTW/IPTP Type 60003 (PTWFREIBURG) is recommended to be exposed 5 to 10 Gy as pre-irradiation just before use. But it is not mentioned how long this effect last. The volume of diamond detector introduced into our hospital was estimated to be 0.3 mm x 12.6 mm sup 2 =3.8 mm sup 3. We did preirradiation of 1.00, 3.00, 5.00 and 9.00 Gy changing the operation day and doses exposed 1.00 Gy were measured at the maximum depth until 90 minutes afterwards at some optional intervals. Those measured means and standard deviations had variations within 0.3% excluding the first value and they were almost the same as those obtained with Japanese Association of Radiological Physicists (JARP) dosimeter. Here, 10 MV x-rays were generated by MEVATRON KD2/50 PRIMUS (TOSHIBA). We usually get data continuously at 1 minute intervals or so and it is not presumed to pause more than 10 minutes, accordingly we measured doses exposed 1.00 Gy at intervals of 1, 2, 5 and 10 minutes on each different day. Those means and sta...

  12. AGC-2 Graphite Pre-irradiation Data Package

    Energy Technology Data Exchange (ETDEWEB)

    David Swank; Joseph Lord; David Rohrbaugh; William Windes

    2010-08-01

    The NGNP Graphite R&D program is currently establishing the safe operating envelope of graphite core components for a Very High Temperature Reactor (VHTR) design. The program is generating quantitative data necessary for predicting the behavior and operating performance of the new nuclear graphite grades. To determine the in-service behavior of the graphite for pebble bed and prismatic designs, the Advanced Graphite Creep (AGC) experiment is underway. This experiment is examining the properties and behavior of nuclear grade graphite over a large spectrum of temperatures, neutron fluences and compressive loads. Each experiment consists of over 400 graphite specimens that are characterized prior to irradiation and following irradiation. Six experiments are planned with the first, AGC-1, currently being irradiated in the Advanced Test Reactor (ATR) and pre-irradiation characterization of the second, AGC-2, completed. This data package establishes the readiness of 512 specimens for assembly into the AGC-2 capsule.

  13. Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Milani, V.; Issels, R.D.; Buecklein, V. [Ludwig-Maximilians-Univ., Muenchen (Germany). Univ. Hospital Grosshadern, Dept. of Internal Medicine III; Institute of Molecular Immunology, Muenchen (Germany). KKG Hyperthermie GSF-Haematologikum; Pazos, M.; Schaffer, P.; Wilkowski, R.; Duehmke, E. [Ludwig-Maximilians-Univ., Muenchen (Germany). Univ. Hospital Grosshadern, Dept. of Radiation Oncology; Rahman, S.; Tschoep, K.; Schaffer, M. [Ludwig-Maximilians-Univ., Muenchen (Germany). Univ. Hospital Grosshadern, Dept. of Internal Medicine III

    2008-03-15

    Background and Purpose: Encouraging results of phase II studies combining chemotherapy with radiotherapy have been published. In this study, the results of a multimodal salvage therapy including radiochemotherapy (RCT) and regional hyperthermia (RHT) in preirradiated patients with recurrent rectal cancer are reported. Patients and Methods: All patients enrolled had received previous pelvic irradiation (median dose 50.4 Gy). The median time interval between prior radiotherapy and the onset of local recurrence was 34 months. The combined treatment consisted of reirradiation with a median dose of 39.6 Gy (30.0-45.0 Gy), delivered in fractions of 1.8 Gy/day. 5-fluorouracil was given as continuous infusion 350 mg/m2/day five times weekly, and RHT (BSD-2000 system) was applied twice a week within 1 h after radiotherapy. The primary endpoint was local progression-free survival (LPFS); secondary endpoints were overall survival, symptom control, and toxicity. Results: 24 patients (median age 59 years) with a previously irradiated locally recurrent adenocarcinoma of the rectum were enrolled. The median LPFS was 15 months (95% confidence interval 12-18 months) with a median follow-up of 27 months (16-37 months). The overall 1-year and 3-year survival rates were 87% and 30%, respectively. Pain was the main symptom in 17 patients. Release of pain was achieved in 12/17 patients (70%). No grade 3 or 4 hematologic or skin toxicity occurred. Grade 3 gastrointestinal acute toxicity was observed in 12.5% of the patients. Paratumoral thermometry revealed a homogeneous distribution of temperatures. Conclusion: RCT combined with RHT is an efficient salvage therapy showing high efficacy with acceptable toxicity and can be recommended as treatment option for this unfavorable group of preirradiated patients with local recurrence of rectal cancer. (orig.)

  14. Thermotolerance in preirradiated intestine and its influence on time-temperature relationships

    Energy Technology Data Exchange (ETDEWEB)

    Hume, S.P.; Marigold, J.C.; Manjil, L.G.

    1988-02-01

    The crypt compartment of mouse jejunum showed a transient increase in thermal susceptibility approximately 10 days after moderate X-ray doses to the abdomen (9-10 Gy). The increase in response was manifest as an increase in slope of the crypt dose-response curve but was limited to temperatures below 43/sup 0/C. As a result, the 43/sup 0/C inflexion in the Arrhenius plot (the relationship between treatment time and temperature) for thermal sensitivity of crypts was eliminated in preirradiated tissue, and the curve became monophasic over the range 42.0-44.5/sup 0/C. At temperatures below 42/sup 0/C, the curve again deviated. At supranormal temperatures of 42/sup 0/C and below, the durations of hyperthermia needed for measurable effect were sufficient to allow thermotolerance to be expressed within the heating period. Neither the threshold heating times nor this thermotolerance were affected by prior irradiation. In the temperature range 42-43/sup 0/C, an earlier development of thermotolerance could be demonstrated in control tissue by challenging with an acute high-temperature heat treatment. This thermotolerance was eliminated in preirradiated tissue, resulting in the apparent increase in sensitivity. The findings support the view that the complex nature of the time-temperature relationship seen in normal tissue in vivo is a manifestation of the ability of the tissue to progressively acquire a thermotolerant state during treatment at temperatures below approximately 43/sup 0/C, so that the intrinsic sensitivity is modulated while being assessed.

  15. AGC-1 Pre-Irradiation Data Report Status

    Energy Technology Data Exchange (ETDEWEB)

    William Windes

    2011-08-01

    The Next Generation Nuclear Plant (NGNP) Graphite R&D program is currently measuring irradiated material property changes in several grades of nuclear graphite for predicting their behavior and operating performance within the core of new Very High Temperature Reactor (VHTR) designs. The Advanced Graphite Creep (AGC) experiment consisting of six irradiation capsules will generate this irradiated graphite performance data for NGNP reactor operating conditions. All samples in the experiment will be fully characterized before irradiation, irradiated in the Advanced Test Reactor (ATR), and then re-examined to determine the irradiation induced changes to key materials properties in the different graphite grades. The information generated during the AGC experiment will be utilized for NRC licensing of NGNP reactor designs, shared with international collaborators in the Generation IV Information Forum (GIF), and eventually utilized in ASME design code for graphite nuclear applications. This status report will describe the process the NGNP Graphite R&D program has developed to record the AGC1 pre-irradiation examination data.

  16. Design of Controllers for Liquid Level Control

    OpenAIRE

    Augustin Simon,; Elizabeth Varghese

    2015-01-01

    The liquid level control system is commonly used in many process control applications. The aim of the process is to keep the liquid level in the tank at the desired value. The conventional proportional-integral-derivative (PID) controller is simple, reliable and eliminates the error rate but it cannot handle complex problems. Fuzzy logic controllers are rule based systems which simulates human behavior of the process. The fuzzy controller is combined with the PID controller and th...

  17. Design of Controllers for Liquid Level Control

    Directory of Open Access Journals (Sweden)

    Augustin Simon,

    2015-08-01

    Full Text Available The liquid level control system is commonly used in many process control applications. The aim of the process is to keep the liquid level in the tank at the desired value. The conventional proportional-integral-derivative (PID controller is simple, reliable and eliminates the error rate but it cannot handle complex problems. Fuzzy logic controllers are rule based systems which simulates human behavior of the process. The fuzzy controller is combined with the PID controller and then applied to the tank level control system. This paper proposes Inverse fuzzy with fuzzy logic controller for controlling liquid level system for a plant. This paper also compares the transient response as well as error indices of PID, Fuzzy logic controller, inverse fuzzy controllers. The responses of the controllers are verified through simulation. From the simulation results, it is observed that inverse fuzzy-PID controller gives the superior performance than the other controllers. The inverse fuzzy-PID controller gives better performance than the PID and fuzzy controller in terms of overshoot and settling time. Performance analysis is carried out with Liquid Flow Control System Design with Fuzzy logic controller. Results are evaluated by comparing the response time of conventional PID, fuzzy logic and Inverse fuzzy controller. Comparative analysis of the performance of different controllers is done in MATLAB and Simulink.

  18. Study on the preirradiation polymerization of vinyl monomers

    Science.gov (United States)

    Yu-Ming, Liu; Yue-Qi, Yang; Zue-Teh, Ma

    This paper presents mainly the polymerization, copolymerization and crosslinking of monomers off-source induced by peroxides which are formed by high energy irradiation of vinyl monomers such as styrene (St), acrylonitrile (AN), methylmethacrylate (MMA), vinyl acetate (VAc) and 2-hydroxyethyl methacrylate (HEMA). The peroxides produced by irradiation of the above-mentioned monomers can not only induce the monomers themselves, but also another non-irradiated monomer to carry out copolymerization efficiently. The activation energy of peroxide formation, the apparent activation energy of polymerization and the activation energy of peroxide initiation by irradiation of vinyl monomers are: Ef(MMA) = 11, Ef(St) = 9.6, Ef(AN) = 8.5, EMMA = EVA = 11.4, Ei(MMA) = Ei(VA) = 13 kcal/mol. The rate of decomposition of monomer peroxides is smoother than that of BPO during the polymerization and so a smooth kinetic progress is obtained. The initiating ability of forming peroxides by irradiation of the vinyl monomers depends mainly on the chemical structure of the monomers. For instance, the main structure of peroxides formed during preirradiation MMA are: alternating peroxy-copolymer ? and random peroxy-copolymer ? Owing to the peroxy-bond which is unstable and in which homolytic breakage easily occurs to yield a pair of radicals, RO . is formed within the above-mentioned structural compounds, so that they possess stronger initiating reactivity. It is quite evident that the initiating reactivity of AN peroxide will be greatly reduced because of the conjugate double bond. In other words, the initiating ability of AN peroxide is lower than MMA peroxide and St peroxide.

  19. Characterization of methyl methacrylate grafting onto preirradiated biodegradable lignocellulose fiber by gamma-radiation.

    Science.gov (United States)

    Khan, Ferdous

    2005-01-14

    Gamma-radiation-induced graft copolymerization of methyl methacrylate onto natural lignocellulose (jute) fiber was carried out by the preirradiation method in an aqueous medium by using octylphenoxy-polyethoxyethanol as an emulsifier. The different factors that influenced the graft copolymer reaction process were investigated. In the case of radiation-dose-dependent grafting, samples irradiated in the presence of air produced up to 73% graft weight compared to 53% obtained in the case of irradiation in a nitrogen environment. By assuming Arrhenius reaction kinetics, the activation energy (E(a)) of the grafting reaction process was evaluated for different reaction temperatures. Moreover, the graft copolymer reaction was controlled by incorporating a homopolymer-inhibiting agent and three different chain-transfer agents in the reaction medium. The mechanical and thermal properties of jute fiber 'as received' and jute-graft-poly(methyl methacrylate) were also investigated. The results showed that the percentage of grafting with jute fiber has a significant effect on the properties. The kinetic parameters were evaluated from TGA thermograms by using Broido's method in the temperature range 240-350 degrees C. Scanning electron micrographs show that the structural changes on the surface of jute fibers were induced by graft copolymerization of methyl methacrylate monomer. Fiber-fiber surface friction was measured in terms of the average maximum load and the kinetic friction. SEM of jute-graft-poly(methyl methacrylate).

  20. Transient fuel behavior of preirradiated PWR fuels under reactivity initiated accident conditions

    Science.gov (United States)

    Fujishiro, Toshio; Yanagisawa, Kazuaki; Ishijima, Kiyomi; Shiba, Koreyuki

    1992-06-01

    Since 1975, extensive studies on transient fuel behavior under reactivity initiated accident (RIA) conditions have been continued in the Nuclear Safety Research Reactor (NSRR) of Japan Atomic Energy Research Institute. A new experimental program with preirradiated LWR fuel rods as test samples has recently been started. In this program, transient behavior and failure initiation have been studied with 14 × 14 type PWR fuel rods preirradiated to a burnup of 20 to 42 MWd/kgU. The test fuel rods contained in a capsule filled with the coolant water were subjected to a pulse irradiation in the NSRR to simulate a prompt power surge in an RIA. The effects of preirradiation on the transient fission gas release, pellet-cladding mechanical interaction and fuel failure were clearly observed through the transient in-core measurements and postirradiation examination.

  1. Development of data base with mechanical properties of un- and pre-irradiated VVER cladding

    Energy Technology Data Exchange (ETDEWEB)

    Asmolov, V.; Yegorova, L.; Kaplar, E.; Lioutov, K. [Nuclear Safety Inst. of Russian Research Centre, Moscow (Russian Federation). Kurchatov Inst.; Smirnov, V.; Prokhorov, V.; Goryachev, A. [State Research Centre, Dimitrovgrad (Russian Federation). Research Inst. of Atomic Reactors

    1998-03-01

    Analysis of recent RIA test with PWR and VVER high burnup fuel, performed at CABRI, NSRR, IGR reactors has shown that the data base with mechanical properties of the preirradiated cladding is necessary to interpret the obtained results. During 1997 the corresponding cycle of investigations for VVER clad material was performed by specialists of NSI RRC KI and RIAR in cooperation with NRC (USA), IPSN (France) in two directions: measurements of mechanical properties of Zr-1%Nb preirradiated cladding versus temperature and strain rate; measurements of failure parameters for gas pressurized cladding tubes. Preliminary results of these investigations are presented in this paper.

  2. Why control blood glucose levels?

    Science.gov (United States)

    Rossini, A A

    1976-03-01

    The controversy as to the relationship between the degree of control of diabetes and the progression of the complications of the disease has not been solved. However, in this review, various studies suggesting a relationship between the metabolic abnormality and the diabetic complications are examined. The disadvantages of the uncontrolled diabetes mellitus can be divided into two major categories-short-term and long-term. The short-term disadvantages of controlled diabetes mellitus include the following: (1) ketoacidosis and hyperosmolar coma; (2) intracellular dehydration; (3) electrolyte imbalance; (4) decreased phagocytosis; (5) immunologic and lymphocyte activity; (6) impairment of wound healing; and (7) abnormality of lipids. The long-term disadvantages of uncontrolled diabetes melitus include the following: (1) nephropathy; (2) neuropathy; (3) retinopathy; (4) cataract formation; (5) effect on perinatal mortality; (6) complications of vascular disease; and (7) the evaluation of various clinical studies suggesting the relationship of elevated blood glucose levels and complications of diabetes mellitus. It is suggested that until the question of control can absolutely be resolved, the recommendation is that the blood glucose levels should be controlled as close to the normal as possible.

  3. Preirradiated Grains in H-Chondritic Regolith Breccias: an In Situ Investigation

    Science.gov (United States)

    Romstedt, J.; Metzler, K.

    1995-09-01

    Introduction: Recently taken photographs of the asteroids Ida and Gaspra show cratered surfaces similar to the moon. Weak outlined craters indicate the existence of regolith layers. Certain meteorites, the regolith breccias, reflect asteroidal regoliths and contain informations about irradiation conditions and gardening processes on asteroidal surfaces. Olivine grain separates of four H-chondritic regolith breccias, Acfer 111, 153, 192 and Bremervorde, were etched for four hours in WN solution [1] to reveal nuclear tracks in olivines. This procedure was done to determine the track "background" produced by galactic cosmic rays (GCR) during transit from the parent body to earth. Additionally whole thin sections of the investigated meteorites were etched for less than thirty minutes to reveal high nuclear track densities which were induced by solar cosmic rays (SCR) on the parent body surface. The short etching time protects extremely high irradiated grains from destruction during the etching procedure. Etched thin sections allows the determination of the spatial distribution of preirradiated components in a given meteorite and a view on the irradiation features of single components within their natural surrounding. Therefore a comparison with the more intensively investigated lunar regolith is possible. Results: I. One of the investigated samples (Acfer 153) shows a layering of preirradiated grains as it is observed in lunar regolith drill cores. Obviously the meteorite samples reflect on a small scale a part of the parent body's stratigraphy [2]. II. The content of preirradiated components varies within the investigated meteorites between Wedekind J. A. (1977) Proc. Symp. Planetary Cratering Mechanics, Pergamon.

  4. Pre-irradiation induced emulsion graft polymerization of acrylonitrile onto polyethylene nonwoven fabric

    Science.gov (United States)

    Liu, Hanzhou; Yu, Ming; Deng, Bo; Li, Linfan; Jiang, Haiqing; Li, Jingye

    2012-01-01

    Acrylonitrile has been widely used in the modification of polymers by graft polymerization. In the present work, pre-irradiation induced emulsion graft polymerization method is used to introduce acrylonitrile onto PE nonwoven fabric instead of the traditional reaction in organic solvents system. The degree of grafting (DG) is measured by gravimetric method and the kinetics of the graft polymerization is studied. The existence of the graft chains is proven by Fourier transform infrared spectroscopy (FT-IR) analysis. Thermal stability of the grafted polymer is measured by Thermogravimetric analysis (TGA).

  5. Pre-irradiation grafting of cellulose and slightly carboxymethylated cellulose (CMC) fibres

    Energy Technology Data Exchange (ETDEWEB)

    Benke, N. [Institute of Isotopes, HAS, Budapest (Hungary); Takacs, E. [Institute of Isotopes, HAS, Budapest (Hungary)]. E-mail: takacs@iki.kfki.hu; Wojnarovits, L. [Institute of Isotopes, HAS, Budapest (Hungary); Borsa, J. [Budapest University of Technology and Economics, Budapest (Hungary)

    2007-08-15

    Acrylamide, hydroxypropyl acrylate, hydroxypropyl methacrylate and 2-ethylhexyl methacrylate vinyl monomers were grafted onto cellulose as well as onto cellulose of improved accessibility (slightly carboxymethylated cellulose (CMC)) by the pre-irradiation grafting technique. The effect of dose, monomer structure, crosslinking agent and carboxymethylation on the grafting yield was studied and the optimal conditions for the grafting were established. Grafting, with the exception of acrylamide (AAm), decreased the swelling of the samples, which is advantageous for some applications. In case of AAm decrease in swelling was observed only when crosslinking agent was applied. At low doses (<5 kGy) the high accessibility of carboxymethylated cellulose resulted in a higher grafting yield.

  6. Acrylation of pre-irradiated polypropylene and its application for removal of organic pollutants

    Science.gov (United States)

    Said, Hossam M.; Sokker, Hesham H.; El-Hag Ali, Amr

    2010-04-01

    Reactive extrusion of pre-irradiated polypropylene (PP) at different doses of gamma radiation was studied in the presence of different concentrations of acrylic acid monomer (AAc). Preliminary investigations study the feasibility or removal of organic pollutants. The optical properties and surface morphology of the grafted polypropylene were observed by FT-IR, UV/vis and scanning electron microscopy (SEM). The affinity of this membrane to the basic dye was found to be increased with increase in the dose of gamma irradiation and the ratio of acrylic acid monomer (AAc).

  7. Research of Liquid Level Control System

    Directory of Open Access Journals (Sweden)

    Dominykas Beištaras

    2015-07-01

    Full Text Available This paper presents liquid level control system model and analysis of dynamic characteristics. The system consists of scalar controlled induction motor drive, fuzzy logic controller, water tank and centrifugal pump. Simulink models of water tank, pump and controller are presented. The simulation of the system shows that the use of fuzzy logic controller reduces valve opening time and reservoir filling time.

  8. Effect of neon plasma pre-irradiation on surface morphology and deuterium retention of tungsten

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, L., E-mail: L.Cheng@buaa.edu.cn [School of Physics & Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); De Temmerman, G.; Zeijlmans van Emmichoven, P.A. [FOM Institute DIFFER, Dutch Institute For Fundamental Energy Research, Association EURATOM-FOM, Trilateral Euregion Cluster, Nieuwegein (Netherlands); Ji, G. [Unité Matériaux et Transformations, UMR CNRS 8207, Université Lille 1, 59655 Villeneuve d’Ascq (France); Zhou, H.B. [School of Physics & Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Wang, B. [College of Materials Science and Engineering, Beijing University of Technology, Beijing 100124 (China); Yuan, Y., E-mail: yueyuan@buaa.edu.cn [School of Physics & Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Zhang, Y. [School of Physics & Nuclear Energy Engineering, Beihang University, Beijing 100191 (China); Lu, G.H., E-mail: LGH@buaa.edu.cn [School of Physics & Nuclear Energy Engineering, Beihang University, Beijing 100191 (China)

    2015-08-15

    Neon and deuterium plasma irradiation of polycrystalline tungsten targets have been performed at high fluxes of ∼10{sup 24} ions m{sup −2} s{sup −1} to study the interaction of neon with tungsten and the influence of neon on deuterium retention. Tungsten exposure to neon plasma leads to the formation of wavy nanostructures on the surface. Subsequent exposure to high-flux deuterium plasma leads to blister formation of micrometer size on top of the wavy structures. The total deuterium retention is decreased by neon pre-irradiation for all surface temperatures used in the present experiments. It is suggested that a barrier of trapped Ne is formed that interrupts the D transport and reduces D retention.

  9. Systematic study of pre-irradiation effects in high efficiency CVD diamond nuclear particle detectors

    CERN Document Server

    Marinelli, M; Milani, E; Paoletti, A; Pillon, M; Tucciarone, A; Verona-Rinati, G

    2002-01-01

    Many outstanding properties of diamond can, in principle, lead to the development of radiation detectors with interesting capabilities. In particular, diamond-based nuclear particle detectors are good candidates to replace silicon-based detectors in several fields, e.g. in high-flux applications such as next generation particle-accelerator experiments or beam monitoring. However, the high concentration of defects (grain boundaries, impurities) in synthetic diamond films can strongly limit the detector's performance. A significant increase in the efficiency of CVD diamond detectors is achieved by means of pre-irradiation (pumping) with beta particles. We report here on a systematic study of the effects of pumping in high-quality microwave CVD diamond films. The efficiency (eta) and charge collection distance (CCD) of nuclear particle detectors based on these films depend on the methane content in the growth gas mixture and on the film thickness. Both efficiency and CCD behave in a markedly different way in the...

  10. Technical safety requirements control level verification

    Energy Technology Data Exchange (ETDEWEB)

    STEWART, J.L.

    1999-05-21

    A Technical Safety Requirement (TSR) control level verification process was developed for the Tank Waste Remediation System (TWRS) TSRs at the Hanford Site in Richland, WA, at the direction of the US. Department of Energy, Richland Operations Office (RL). The objective of the effort was to develop a process to ensure that the TWRS TSR controls are designated and managed at the appropriate levels as Safety Limits (SLs), Limiting Control Settings (LCSs), Limiting Conditions for Operation (LCOs), Administrative Controls (ACs), or Design Features. The TSR control level verification process was developed and implemented by a team of contractor personnel with the participation of Fluor Daniel Hanford, Inc. (FDH), the Project Hanford Management Contract (PHMC) integrating contractor, and RL representatives. The team was composed of individuals with the following experience base: nuclear safety analysis; licensing; nuclear industry and DOE-complex TSR preparation/review experience; tank farm operations; FDH policy and compliance; and RL-TWRS oversight. Each TSR control level designation was completed utilizing TSR control logic diagrams and TSR criteria checklists based on DOE Orders, Standards, Contractor TSR policy, and other guidance. The control logic diagrams and criteria checklists were reviewed and modified by team members during team meetings. The TSR control level verification process was used to systematically evaluate 12 LCOs, 22 AC programs, and approximately 100 program key elements identified in the TWRS TSR document. The verification of each TSR control required a team consensus. Based on the results of the process, refinements were identified and the TWRS TSRs were modified as appropriate. A final report documenting key assumptions and the control level designation for each TSR control was prepared and is maintained on file for future reference. The results of the process were used as a reference in the RL review of the final TWRS TSRs and control suite. RL

  11. Development of Mechanical Water Level Controller

    OpenAIRE

    Akonyi Nasiru Sule; Chinedu Cletus Obinwa; Christian Ebele Okekeze; Eyo Ifreke

    2012-01-01

    The automatic water level controller is a device designed to regulate automatically the pumping of water to an overhead tank without allowing the water in the tank to be exhausted. The design of this mechanical device was achieved using the Archimedes principle of floatation; having a float which determines the water level in the tank depending on the choice of the minimum (lower) and maximum (upper) level inscribed in the tank. The fundamental attribute of this device is the ease in design, ...

  12. Models, controls, and levels of semiotic autonomy

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, C.

    1998-12-01

    In this paper the authors consider forms of autonomy, forms of semiotic systems, and any necessary relations among them. Levels of autonomy are identified as levels of system identity, from adiabatic closure to disintegration. Forms of autonomy or closure in systems are also recognized, including physical, dynamical, functional, and semiotic. Models and controls are canonical linear and circular (closed) semiotic relations respectively. They conclude that only at higher levels of autonomy do semiotic properties become necessary. In particular, all control systems display at least a minimal degree of semiotic autonomy; and all systems with sufficiently interesting functional autonomy are semiotically related to their environments.

  13. Application of Adaptive Fuzzy PID Leveling Controller

    Directory of Open Access Journals (Sweden)

    Ke Zhang

    2013-05-01

    Full Text Available Aiming at the levelling precision, speed and stability of suspended access platform, this paper put forward a new adaptive fuzzy PID control levelling algorithm by fuzzy theory. The method is aided design by using the SIMULINK toolbox of MATLAB, and setting the membership function and the fuzzy-PID control rule. The levelling algorithm can real-time adjust the three parameters of PID according to the fuzzy rules due to the current state. It is experimented, which is verified the algorithm have better stability and dynamic performance.

  14. Pre-irradiation testing of actively cooled Be-Cu divertor modules

    Energy Technology Data Exchange (ETDEWEB)

    Linke, J.; Duwe, R.; Kuehnlein, W. [Forschungszentrum Juelich GmbH (Germany)] [and others

    1995-09-01

    A set of neutron irradiation tests is prepared on different plasma facing materials (PFM) candidates and miniaturized components for ITER. Beside beryllium the irradiation program which will be performed in the High Flux Reactor (HFR) in Petten, includes different carbon fiber composites (CFQ) and tungsten alloys. The target values for the neutron irradiation will be 0.5 dpa at temperatures of 350{degrees}C and 700{degrees}C, resp.. The post irradiation examination (PIE) will cover a wide range of mechanical tests; in addition the degradation of thermal conductivity will be investigated. To determine the high heat flux (HHF) performance of actively cooled divertor modules, electron beam tests which simulate the expected heat loads during the operation of ITER, are scheduled in the hot cell electron beam facility JUDITH. These tests on a selection of different actively cooled beryllium-copper and CFC-copper divertor modules are performed before and after neutron irradiation; the pre-irradiation testing is an essential part of the program to quantify the zero-fluence high heat flux performance and to detect defects in the modules, in particular in the brazed joints.

  15. Control of System with Defined Risk Level

    Directory of Open Access Journals (Sweden)

    Pavol Tomasov

    2002-01-01

    Full Text Available In the following paper the basic requirements for system control with defined risk level is presented. The paper should be an introduction to describe of theoretical apparatus, which was created during some years of research work in the Department of information and safety systems in this area. It a modification or creation of new parts of Information theory, System theory, and Control theory means. This parts are necessary for the analysis and synthesis tasks in the systems where dominant attribute of control is defined risk level. The basic problem is the creation of protect mechanism again the threats from inside and from controlled system environs. For each risk reduction mechanism is needed some redundancy which should be into control algorithm to put by exactly determined way.

  16. Development of Mechanical Water Level Controller

    Directory of Open Access Journals (Sweden)

    Akonyi Nasiru Sule

    2012-10-01

    Full Text Available The automatic water level controller is a device designed to regulate automatically the pumping of water to an overhead tank without allowing the water in the tank to be exhausted. The design of this mechanical device was achieved using the Archimedes principle of floatation; having a float which determines the water level in the tank depending on the choice of the minimum (lower and maximum (upper level inscribed in the tank. The fundamental attribute of this device is the ease in design, fabrication and mounting at a lower cost. Its testing had shown and proved that it works efficiently with Archimedes’ principle of floatation. This eliminates the frequent human intervention/monitoring of the water level in the overhead tank to control overflow manually, thereby eliminating water and energy wastages.

  17. System level modeling and component level control of fuel cells

    Science.gov (United States)

    Xue, Xingjian

    This dissertation investigates the fuel cell systems and the related technologies in three aspects: (1) system-level dynamic modeling of both PEM fuel cell (PEMFC) and solid oxide fuel cell (SOFC); (2) condition monitoring scheme development of PEM fuel cell system using model-based statistical method; and (3) strategy and algorithm development of precision control with potential application in energy systems. The dissertation first presents a system level dynamic modeling strategy for PEM fuel cells. It is well known that water plays a critical role in PEM fuel cell operations. It makes the membrane function appropriately and improves the durability. The low temperature operating conditions, however, impose modeling difficulties in characterizing the liquid-vapor two phase change phenomenon, which becomes even more complex under dynamic operating conditions. This dissertation proposes an innovative method to characterize this phenomenon, and builds a comprehensive model for PEM fuel cell at the system level. The model features the complete characterization of multi-physics dynamic coupling effects with the inclusion of dynamic phase change. The model is validated using Ballard stack experimental result from open literature. The system behavior and the internal coupling effects are also investigated using this model under various operating conditions. Anode-supported tubular SOFC is also investigated in the dissertation. While the Nernst potential plays a central role in characterizing the electrochemical performance, the traditional Nernst equation may lead to incorrect analysis results under dynamic operating conditions due to the current reverse flow phenomenon. This dissertation presents a systematic study in this regard to incorporate a modified Nernst potential expression and the heat/mass transfer into the analysis. The model is used to investigate the limitations and optimal results of various operating conditions; it can also be utilized to perform the

  18. Mining level of control in medical organizations.

    Science.gov (United States)

    Çalimli, Olgu; Türkeli, Serkan; Eken, Emir Gökberk; Gönen, Halil Emre

    2014-01-01

    In literature of strategic management, there are three layers of control defined in organizational structures. These layers are strategic, tactical and operational, in which resides senior, medium level and low level managers respectively. In strategic level, institutional strategies are determined according to senior managers' perceived state of organization. In tactical level, this strategy is processed into methods and activities of a business management plan. Operational level embodies actions and functions to sustain specified business management plan. An acknowledged lead organization in Turkish medical area is examined using case study and data mining method in the scope of this paper. The level of decisions regarded in managerial purposes evaluated through chosen organization's business intelligence event logs report. Hence specification of management level importance of medical organizations is made. Case study, data mining and descriptive statistical method of taken case's reports present that positions of "Chief Executive Officer", "Outpatient Center Manager", "General Manager", monitored and analyzed functions of operational level management more frequently than strategic and tactical level. Absence of strategic management decision level research in medical area distinguishes this paper and consequently substantiates its significant contribution.

  19. Grafting poly(vinyl alcohol) onto polybutadiene rubber latex particles by pre-irradiation

    Science.gov (United States)

    Tian, Bo; Dong, Wei; Liu, Yuguang

    2017-06-01

    Poly(vinyl alcohol) (PVA) was grafted on polybutadiene rubber latex (PBL) particles (PB-g-PVA) by pre-irradiation via emulsion grafting copolymerization. The grafting degree (G%) increased almost linearly with the reaction time and the weight ratio of PVA to the PB latex, while decreased gradually when the irradiation dose is over 30 kGy and the reaction temperature is higher than 60 °C. The grafting efficiency (GE%) has the same trend of the G% but the weight ratio of PVA to PBL, GE% decreased with increasing of PVA adding to PB latex. FTIR spectroscopy indicated that the PVA was grafted onto the PB particles. The dynamic light scattering measurement showed that the particle size of PB-g-PVA particles was larger than that of the pristine PBL particles, and it increased with increment of G%. Transmission electron microscopy images of the PB-g-PVA latex particles demonstrated that the size of PB-g-PVA particle was enlarged by the layer of grafted PVA surrounding the PBL particles. Thermal behavior exhibited the phase separation in the PB-g-PVA films, Tg1 and Tg2 related to the PB and PVA respectively, both of which shifted to a higher temperature with increasing of G%, but the Tg2 was still lower than that of the virgin PVA. The increment of the surface free energy of PB-g-PVA films was attributed to the incorporation of the polar PVA, which also resulted in improvement of the hydrophilic properties.

  20. Effects of the pre-irradiation storage procedure on the dose response of a Fricke xylenol orange gel dosimeter

    Directory of Open Access Journals (Sweden)

    Liosi Giulia Maria

    2015-09-01

    Full Text Available The Fricke xylenol orange (FX gel system is a chemical dosimeter characterized by good sensitivity, linear dose response, tissue equivalence, no toxicity, easy preparation, reproducibility and low cost. Thanks to the presence of the gelatinous matrix, the system is particularly suitable to perform reliable 3D mapping of the absorbed dose spatial distribution via magnetic resonance imaging (MRI or optical techniques. The aim of this work is to study in a systematic way the influence of the pre-irradiation storage procedure upon sensitivity, dose response stability and lifetime of use of a FX gel system made with gelatin from porcine skin subjected to homogeneous irradiation. For this purpose, different pre-irradiation storage procedures, in terms of temperature and duration of each storage step, were investigated. In order to evaluate the dose response stability, the optical analyses of the samples were performed up to 6 hours after irradiation. Moreover, the samples were irradiated at time intervals of 24 hours for up to 7 days after preparation in order to evaluate the system lifetime of use. Regardless of their thermal and temporal life, the samples show linear dose responses in the investigated dose range (3-24 Gy and an increase of sensitivity with the time elapsed between preparation and irradiation. Among the three pre-irradiation storage procedures considered here, a procedure that provides the best dose response stability and lifetime of use was identified and recommended for further use. The analyzed dosimetric system possesses good properties that make it promising for medical application, particularly concerning the evaluation of pre-treatment plan quality assurance within the conformational external beam radiotherapy

  1. Pre-irradiation induced emulsion co-graft polymerization of acrylonitrile and acrylic acid onto a polyethylene nonwoven fabric

    Science.gov (United States)

    Liu, Hanzhou; Yu, Ming; Ma, Hongjuan; Wang, Ziqiang; Li, Linfan; Li, Jingye

    2014-01-01

    A pre-irradiation induced emulsion co-graft polymerization method was used to introduce acrylonitrile and acrylic acid onto a PE nonwoven fabric. The use of acrylic acid is meant to improve the hydrophilicity of the modified fabric. The kinetics of co-graft polymerization were studied. The existence of polyacrylonitrile (PAN) and poly(acrylic acid) (PAAc) graft chains was proven by Fourier transform infrared spectroscopy (FTIR) analysis. The existence of the nitrile groups in the graft chains indicates that they are ready for further amidoximation and adsorption of heavy metal ions.

  2. Effect of Pre-Irradiation Annealing and Laser Modification on the Formation of Radiation-Induced Surface Color Centers in Lithium Fluoride

    Science.gov (United States)

    Voitovich, A. P.; Kalinov, V. S.; Novikov, A. N.; Radkevich, A. V.; Runets, L. P.; Stupak, A. P.; Tarasenko, N. V.

    2017-01-01

    It is shown that surface color centers of the same type are formed in the surface layer and in regions with damaged crystal structure inside crystalline lithium fluoride after γ-irradiation. Results are presented from a study of the effect of pre-irradiation annealing on the efficiency with which surface centers are formed in lithium fluoride nanocrystals. Raising the temperature for pre-irradiation annealing from room temperature to 250°C leads to a substantial reduction in the efficiency with which these centers are created. Surface color centers are not detected after γ-irradiation for pre-irradiation annealing temperatures of 300°C and above. Adsorption of atmospheric gases on the crystal surface cannot be regarded as a necessary condition for the formation of radiation-induced surface centers.

  3. Pre-irradiation and surgical intervention in patients with squamous cell carcinomas of the oral cavity and the oropharynx: Results of a study conducted from 1973 to 1984

    Energy Technology Data Exchange (ETDEWEB)

    Knoebber, D.; Sack, H.; Stuetzer, H.; Rose, K.G.

    1987-11-01

    In collaboration with the Radiotherapeutic Hospital, 87 patients with squamous cell carcinomas of the oral cavity and the oropharynx were treated by combined pre-irradiation and surgical intervention at the University ORL Hospital of Cologne. The study was supposed to improve the five-year survival of patients suffering from advanced carcinomas of the head and neck area. The male and female patient's ratio was 4,5 to 1. Half of the patients had squamous cell carcinomas of the oropharynx, 21 patients had tumors of the floor of the mouth, and another 21 had tumors of the anterior two thirds of the tongue. The tumor and lymph node status was classified according to the UICC regulations (1979). In the pre-irradiation, 40 to 50 Gy were applied to the primary tumor and the regional lymph nodes. Surgery was executed generally four weeks after pre-irradiation. The tumor remission following to pre-irradiation was very good. 27% of the patients showed little or moderate post-operative disturbances in wound healing. An osteoradionecrosis was found in 4,6%. Almost 25% of the patients developed local recurrences. The cumulated five-year survival of all patients is 32%. In dependence on TNM stages, the three-year survival rates are as follows: stage I and II 80%, stage III 44%, and stage IV 40%.

  4. Behavior of pre-irradiated fuel under a simulated RIA condition. Results of NSRR Test JM-5

    Energy Technology Data Exchange (ETDEWEB)

    Fuketa, Toyoshi; Sasajima, Hideo; Mori, Yukihide; Tanzawa, Sadamitsu; Ishijima, Kiyomi; Kobayashi, Shinsho; Kamata, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Homma, Kozo; Sakai, Haruyuki

    1995-11-01

    This report presents results from the power burst experiment with pre-irradiated fuel rod, Test JM-5, conducted in the Nuclear Safety Research Reactor (NSRR). The data concerning test method, pre-irradiation, pre-pulse fuel examination, pulse irradiation, transient records and post-pulse fuel examination are described, and interpretations and discussions of the results are presented. Preceding to the pulse irradiation in the NSRR, test fuel rod was irradiated in the Japan Materials Testing Reactor (JMTR) up to a fuel burnup of 25.7 MWd/kgU with average linear heat rate of 33.4 kW/m. The fuel rod was subjected to the pulse irradiation resulting in a desposited energy of 223 {+-} 7 cal/g{center_dot}fuel (0.93 {+-} 0.03 kJ/g{center_dot}fuel) and a peak fuel enthalpy of 167 {+-} 5 cal/g{center_dot}fuel (0.70 {+-} 0.02 kJ/g{center_dot}fuel) under stagnant water cooling condition at atmospheric pressure and ambient temperature. Test fuel rod behavior was assessed from pre- and post-pulse fuel examinations and transient records during the pulse. The Test JM-5 resulted in cladding failure. More than twenty small cracks were found in the post-test cladding, and most of the defects located in pre-existing locally hydrided region. The result indicates an occurrence of fuel failure by PCMI (pellet/cladding mechanical interaction) in combination with decreased integrity of hydrided cladding. (author).

  5. Command Post Exercise Control at Division Level

    Science.gov (United States)

    1964-05-01

    play. 7. vlar gaming methods utilized. 45Rudolf, War Games ( MSIP - 094, 1952), P• 22. ( ( ( 102 8. Intelligenc e play. 9. CBR play. Other areas...Army, MS #P-094, Washington , D. C., 1952. Howell, Robert P. Comments on CPX Control , Seventh Corps~ HQ Seventh Corps, APO 107, N.Y., N.Y., 14 Feb

  6. [Influence on measurements of pre-irradiation due to differences in ionization chamber shape or frequency in use].

    Science.gov (United States)

    Shimono, Tetsunori; Nambu, Hidekazu; Matsubara, Kosuke; Koshida, Kichiro; Gomi, Tsutomu

    2012-01-01

    Ionization chamber measurements in radiation therapy should be repeatedly performed until a stable reading is obtained. Ionization chambers exhibit a response which depends on time elapsed since the previous irradiation. In this study, we investigated the response of a set of two Farmer-style, one Plane parallel, and seven small ionization chambers, which are exposed to 4, 6, 10, and 14 MV. The results show that Farmer-style and Plane parallel ionization chambers settle quickly within 9-20 min. On the other hand, small ionization chambers exhibit settling times of 12-33 min for 6, 10, and 14 MV. It will take longer for a settling time of 4 MV. The settling time showed time dependent irradiation. The first reading was up to 0.76% lower in the Farmer-style and Plane parallel ionization chambers. The small ionization chambers had a 2.60% lower first reading and more gradual response in reaching a stable reading. In this study, individual ionization chambers can vary significantly in their settling behavior. Variation of the responses on ionization chambers were confirmed not only when radiation was not used for a week but also when it was halted for a month. Pre-irradiation of small ionization chambers is clearly warranted for eliminating inadvertent error in the calibration of radiation beams.

  7. Preparation and characterization of mono-sheet bipolar membranes by pre-irradiation grafting method for fuel cell applications

    Science.gov (United States)

    Guan, Yingjie; Fang, Jun; Fu, Tao; Zhou, Huili; Wang, Xin; Deng, Zixiang; Zhao, Jinbao

    2016-09-01

    A new method for the preparation of the mono-sheet bipolar membrane applied to fuel cells was developed based on the pre-irradiation grafting technology. A series of bipolar membranes were successfully prepared by simultaneously grafting of styrene onto one side of the poly(ethylene-co-tetrafluoroethylene) base film and 1-vinylimidazole onto the opposite side, followed by the sulfonation and alkylation, respectively. The chemical structures and microstructures of the prepared membranes were investigated by ATR-FTIR and SEM-EDS. The TGA measurements demonstrated the prepared bipolar membranes have reasonable thermal stability. The ion exchange capacity, water uptake and ionic conductivity of the membranes were also characterized. The H2/O2 single fuel cells using these membranes were evaluated and revealed a maximum power density of 107 mW cm-2 at 35 °C with unhumidified hydrogen and oxygen. The preliminary performances suggested the great prospect of these membranes in application of bipolar membrane fuel cells.

  8. Influence of grafting solvents on the properties of polymer electrolyte membranes prepared by {gamma}-ray preirradiation method

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Yosuke [Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376 8515 (Japan)], E-mail: yosuke.kimura@jaea.go.jp; Asano, Masaharu; Chen, Jinhua; Maekawa, Yasunari [Environment and Industrial Materials Research Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA), 1233 Watanuki-machi, Takasaki, Gunma 370 1292 (Japan); Katakai, Ryoichi [Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376 8515 (Japan); Yoshida, Masaru [Environment and Industrial Materials Research Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA), 1233 Watanuki-machi, Takasaki, Gunma 370 1292 (Japan)

    2008-07-15

    The effect of grafting solvents, such as isopropanol (iPrOH), tetrachloroethane (TCE), tetrahydrofuran (THF), and toluene, on the preparation of poly(ethylene-co-tetrafluoroethylene)-graft-poly(styrene sulfonic acid) (ETFE-g-PSSA) electrolyte membranes by the {gamma}-ray preirradiation grafting method was investigated. It was found that the iPrOH can drastically accelerate the grafting, resulting in a higher degree of grafting. However, for an appropriate degree of grafting of about 50%, the sulfonic acid groups in the ETFE-g-PSSA membrane prepared with the iPrOH were mainly distributed near the membrane surface, as shown by low proton conductivity in the membrane thickness direction. In contrast to this result, the ETFE-g-PSSA membranes prepared with the THF, toluene and TCE exhibited uniform distribution of the sulfonic acid groups in the membrane. Especially, in the case of the TCE grafting solvent, the chemical stability of the resultant electrolyte membrane was clearly higher than those prepared with the other grafting solvents.

  9. Performance Comparison Of Different Controllers For A Level Process

    Directory of Open Access Journals (Sweden)

    S.Abirami

    2014-03-01

    Full Text Available The analysis study has been done for a First Order plus Delay Time (FOPDT model controlled by Proportional Integral Derivative (PID, proportional integral (PI and Model Predictive Control (MPC using MATLAB software. The study has been done for both MPC and conventional control methods to design the controller for the level tank system and the results has been compared in terms of rise time,settling time and maximum overshoot. The conventional PID controller gives corrective action only after error has developed but not in advance but MPC provides corrective action in advance. The objective of this study is to investigate the Model predictive control (MPC strategy, analyze and compare the control effects with conventional control strategy in maintaining a water level system. A Comparison between the performance of Conventional controller and MPC Controller has been performed in which MPC Controller gives better system parameter in terms of Rise time (tr, Settling time (ts and maximum overshoot (Mp.

  10. 低剂量辐射对环磷酰胺化疗毒性作用的影响%Effects of low dose pre-irradiation on the toxicity of cyclophosphamide

    Institute of Scientific and Technical Information of China (English)

    Hongsheng Yu; Li Yu; Aiqin Song; Zimin Liu; Yeling Zhang; Xinjia He

    2011-01-01

    Objective:The aim of the study was to investigate the effects as well as the possible mechanisms of low dose y-ray pre-irradiation on hepatic damage, DNA damage of peripheral lymphocytes and genetic material damage caused by high dosage of cyclophosphamide (CTX). Methods: Kunming strain male mice were randomly divided into five groups:control group, sham-irradiated group, low dose irradiation group (LDR group), cyclophosphamide chemotherapy group (CTX group) and low close irradiation combined with chemotherapy group (LDR + CTX group). Having being raised for one week,all the mice were implanted subcutaneously with S180 cells in the left inguen (control group excluded). On days 8 and 11,mice of LDR and LDR + CTX groups were given 75 mGy whole-body y-irradiation, 30 h later mice of CTX and LDR + CTX groups were injected I.p. 3.0 mg cyclophosphamide. All the mice were sacrificed on day 13. DNA damage of the peripheral lymphocytes was analyzed using single cell gel electrophoresis (SCGE); ALT activity, total protein (TP) and albumin (ALB)of the plasma were analyzed using automatic biochemistry analyzer; MDA content, SOD and GSH-PX activity of the hepatic homogenate were analyzed using chromometry; genetic material damage was analyzed using micronucleus frequency (MNF)of polychromatoerythrocytes (PCE) in bone marrow. Results: 1. Differences of MDA contents, SOD and GSH-PX activity of hepatic homogenate between 5 groups had notable statistical significance (P 0.05). Differences of TP and ALB of plasma between 5 groups had statistical sig-nificance (F = 12.879 and 6.336 respectively, P 0.05). Conclusion:1. CTX can damage the hepatic tissue through oxidative stress; 75 mGy y-irradiation before CTX chemotherapy can induce activities of anti-oxidative enzymes, promote elimination of free radicals, so as to alleviate the damaging effects of oxidative stress to hepatic tissue caused by high-close chemotherapy. 2. A 75 mGy y-irradiation before CTX chemotherapy has no obvious

  11. Data requirements for traffic control on a macroscopic level

    NARCIS (Netherlands)

    Knoop, V.L.; Van Lint, J.W.C.; Hoogendoorn, S.P.

    2011-01-01

    With current techniques, traffic monitoring and control is a data intensive process. Network control on a higher level, using high level variables, can make this process less data demanding. The macroscopic fundamental diagram relates accumulation, i.e. the number of vehicles in an area, to the netw

  12. Simulating a fuzzy level controller for flotation columns

    Institute of Scientific and Technical Information of China (English)

    Liao Yinfei; Liu Jiongtian; Wang Yongtian; Cao Yijun

    2011-01-01

    Level control in flotation columns is an important factor that influences the recovery and the grade of concentrate from the column.A flotation column is a nonlinear,multi-variable problem with changeable parameters that traditional methods have difficulty controlling.We have applied fuzzy control methods to the flotation column and tested the performance of the design by Matlab/Simulink simulation.The simulations show that level control in the flotation column becomes smoother and more rapid with the fuzzy controller.Compared to PID control methods the overshoot in valve position,the adjustment time,and the robustness of the controller are all improved.This indicates that it is suitable to model fuzzy controllers in applications for the study of automatic control of flotation column.

  13. High Level Waste (HLW) Feed Process Control Strategy

    Energy Technology Data Exchange (ETDEWEB)

    STAEHR, T.W.

    2000-06-14

    The primary purpose of this document is to describe the overall process control strategy for monitoring and controlling the functions associated with the Phase 1B high-level waste feed delivery. This document provides the basis for process monitoring and control functions and requirements needed throughput the double-shell tank system during Phase 1 high-level waste feed delivery. This document is intended to be used by (1) the developers of the future Process Control Plan and (2) the developers of the monitoring and control system.

  14. Application of Fuzzy Logic Controller to Level Control of Twin-Roll Strip Casting

    Institute of Scientific and Technical Information of China (English)

    QI Chun-yu; DI Hong-shuang; ZHANG Xiao-ming; GAO De-fu

    2003-01-01

    An intelligent fuzzy-PID controller consisting of fuzzy logic controller and PID controller was developed to control the molten steel level of twin-roll strip caster. Additionally, a feedforward differential PID controller was used for stopper position control in order to avoid differential kick. It is proved by simulation that the proposed intelligent controller is able to obtain zero steady state error asymptotically and the control system is robust due to its fuggy behavior of the controller.

  15. DeviceNet-based device-level control in SSRF

    CERN Document Server

    Leng Yong Bin; Lu Cheng Meng; Miao Hai Feng; Liu Song Qiang; Shen Guo Bao

    2002-01-01

    The control system of Shanghai Synchrotron Radiation Facility is an EPICS-based distributed system. One of the key techniques to construct the system is the device-level control. The author describes the design and implementation of the DeviceNet-based device controller. A prototype of the device controller was tested in the experiments of magnet power supply and the result showed a precision of 3 x 10 sup - sup 5

  16. Comparison of time optimal control for two level quantum systems

    Institute of Scientific and Technical Information of China (English)

    Shuang Cong; Jie Wen; Xubo Zou

    2014-01-01

    The time optimal problem for a two level quantum sys-tem is studied. We compare two different control strategies of bang-bang control and the geometric control, respectively, es-pecial y in the case of minimizing the time of steering the state from North Pole to South Pole on the Bloch sphere with bounded control. The time performances are compared for different param-eters by the individual numerical simulation experiments, and the experimental results are analyzed. The results show that the ge-ometric control spends less time than the bang-bang control does.

  17. Helium-neon laser preirradiation induces protection against UVC radiation in wild-type E. coli strain K12AB1157.

    Science.gov (United States)

    Kohli, R; Gupta, P K; Dube, A

    2000-02-01

    We have observed that preirradiation with a helium-neon laser (632.8 nm) induces protection against UVC radiation in wild-type E. coli strain K12AB1157. The magnitude of protection was found to depend on the helium-neon laser irradiance, exposure time, and period of incubation between helium-neon laser exposure and subsequent UVC irradiation. The optimum values for dose, irradiance and interval between the two exposures were found to be 7 kJ/m(2), 100 W/m(2) and 1 h, respectively. The possible involvement of singlet oxygen in the helium-neon laser-induced protection is also discussed.

  18. Radio Frequency Based Water Level Monitor and Controller for ...

    African Journals Online (AJOL)

    Radio Frequency Based Water Level Monitor and Controller for Residential Applications. ... Nigerian Journal of Technology ... This paper elucidates a radio frequency (RF) based transmission and reception system used to remotely monitor ...

  19. Automatic reference level control for an antenna pattern recording system

    Science.gov (United States)

    Lipin, R., Jr.

    1971-01-01

    Automatic gain control system keeps recorder reference levels within 0.2 decibels during operation. System reduces recorder drift during antenna radiation distribution determinations over an eight hour period.

  20. Adaptive Backstepping Controller Design for Leveling Control of an Underwater Platform Based on Joint Space

    Directory of Open Access Journals (Sweden)

    Zhi-Lin Zeng

    2014-01-01

    Full Text Available This paper focuses on high precision leveling control of an underwater heavy load platform, which is viewed as an underwater parallel robot on the basis of its work pattern. The kinematic of platform with deformation is analyzed and the dynamics model of joint space is established. An adaptive backstepping controller according to Lyapunov's function is proposed for leveling control of platform based on joint space. Furthermore, the “lowest point fixed angle error” leveling scheme called “chase” is chosen for leveling control of platform. The digital simulation and practical experiment of single joint space actuator are carried out, and the results show high precision servo control of joint space. On the basis of this, the platform leveling control simulation relies on the hardware-in-loop system. The results indicate that the proposed controller can effectively restrain the influence from system parameter uncertainties and external disturbance to realize high precision leveling control of the underwater platform.

  1. Control of lipid oxidation at the mitochondrial level

    DEFF Research Database (Denmark)

    Sahlin, Kent

    2009-01-01

    , but the mechanisms regulating fuel preferences remain unclear. During intense exercise, oxidation of long-chain fatty acids (LCFAs) decreases, and the major control is likely to be at the mitochondrial level. Potential mitochondrial sites for control of lipid oxidation include transport of LCFAs into mitochondrial...

  2. Two-level tuning of fuzzy PID controllers.

    Science.gov (United States)

    Mann, G I; Hu, B G; Gosine, R G

    2001-01-01

    Fuzzy PID tuning requires two stages of tuning; low level tuning followed by high level tuning. At the higher level, a nonlinear tuning is performed to determine the nonlinear characteristics of the fuzzy output. At the lower level, a linear tuning is performed to determine the linear characteristics of the fuzzy output for achieving overall performance of fuzzy control. First, different fuzzy systems are defined and then simplified for two-point control. Non-linearity tuning diagrams are constructed for fuzzy systems in order to perform high level tuning. The linear tuning parameters are deduced from the conventional PID tuning knowledge. Using the tuning diagrams, high level tuning heuristics are developed. Finally, different applications are demonstrated to show the validity of the proposed tuning method.

  3. Quantized Feedback Control Software Synthesis from System Level Formal Specifications

    CERN Document Server

    Mari, Federico; Salvo, Ivano; Tronci, Enrico

    2011-01-01

    Many Embedded Systems are indeed Software Based Control Systems (SBCSs), that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of SBCS control software. We present an algorithm, along with a tool QKS implementing it, that from a formal model (as a Discrete Time Linear Hybrid System, DTLHS) of the controlled system (plant), implementation specifications (that is, number of bits in the Analog-to-Digital, AD, conversion) and System Level Formal Specifications (that is, safety and liveness requirements for the closed loop system) returns correct-by-construction control software that has a Worst Case Execution Time (WCET) linear in the number of AD bits and meets the given specifications. We show feasibility of our approach by presenting experimental results on using it to synthesize control software for a buck DC-DC converter, a widely used mixed-mode analog circuit.

  4. Adaptive control with an expert system based supervisory level. Thesis

    Science.gov (United States)

    Sullivan, Gerald A.

    1991-01-01

    Adaptive control is presently one of the methods available which may be used to control plants with poorly modelled dynamics or time varying dynamics. Although many variations of adaptive controllers exist, a common characteristic of all adaptive control schemes, is that input/output measurements from the plant are used to adjust a control law in an on-line fashion. Ideally the adjustment mechanism of the adaptive controller is able to learn enough about the dynamics of the plant from input/output measurements to effectively control the plant. In practice, problems such as measurement noise, controller saturation, and incorrect model order, to name a few, may prevent proper adjustment of the controller and poor performance or instability result. In this work we set out to avoid the inadequacies of procedurally implemented safety nets, by introducing a two level control scheme in which an expert system based 'supervisor' at the upper level provides all the safety net functions for an adaptive controller at the lower level. The expert system is based on a shell called IPEX, (Interactive Process EXpert), that we developed specifically for the diagnosis and treatment of dynamic systems. Some of the more important functions that the IPEX system provides are: (1) temporal reasoning; (2) planning of diagnostic activities; and (3) interactive diagnosis. Also, because knowledge and control logic are separate, the incorporation of new diagnostic and treatment knowledge is relatively simple. We note that the flexibility available in the system to express diagnostic and treatment knowledge, allows much greater functionality than could ever be reasonably expected from procedural implementations of safety nets. The remainder of this chapter is divided into three sections. In section 1.1 we give a detailed review of the literature in the area of supervisory systems for adaptive controllers. In particular, we describe the evolution of safety nets from simple ad hoc techniques, up

  5. Effects of zinc oxide and titanium dioxide nanoparticles on green algae under visible, UVA, and UVB irradiations: no evidence of enhanced algal toxicity under UV pre-irradiation.

    Science.gov (United States)

    Lee, Woo-Mi; An, Youn-Joo

    2013-04-01

    Some metal oxide nanoparticles are photoreactive, thus raising concerns regarding phototoxicity. This study evaluated ecotoxic effects of zinc oxide nanoparticles and titanium dioxide nanoparticles to the green algae Pseudokirchneriella subcapitata under visible, UVA, and UVB irradiation conditions. The nanoparticles were prepared in algal test medium, and the test units were pre-irradiated by UV light in a photoreactor. Algal assays were also conducted with visible, UVA or UVB lights only without nanoparticles. Algal growth was found to be inhibited as the nanoparticle concentration increased, and ZnO NPs caused destabilization of the cell membranes. We also noted that the inhibitory effects on the growth of algae were not enhanced under UV pre-irradiation conditions. This phenomenon was attributed to the photocatalytic activities of ZnO NPs and TiO2 NPs in both the visible and UV regions. The toxicity of ZnO NPs was almost entirely the consequence of the dissolved free zinc ions. This study provides us with an improved understanding of toxicity of photoreactive nanoparticles as related to the effects of visible and UV lights. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. High Level Control Applications for SOLEIL Commissioning and Operation

    CERN Document Server

    Nadolski, Laurent S; Ho, Katy; Leclercq, Nicolas; Ounsy, Majid; Petit, Sylvain

    2005-01-01

    The SOLEIL control system, namely TANGO developed in collaboration with ESRF, is now mature and stable. TANGO has also been chosen now by several other laboratories. High-level control applications implemented in the control room for the storage ring, the two transfer lines, and the booster will be described in this paper. Three kinds of tools for commissioning are used. First the generic TANGO tools (alarms, simple graphical control applications), which allow us to control in a simple way any TANGO Device Server. Secondly a Matlab Middle Layer (adapted from ALS and SPEAR3): Matlab is fully interconnected with TANGO; it is used primarily for writing Physics control applications. Finally Globalscreen, a commercial SCADA software devoted for building operation applications has been selected (panels for controlling or displaying setpoint, readback values, status of equipments). In addition an overview of the historical and short-term databases for the accelerators will be given. They have been developed in house...

  7. Quadratic controller syntheses for the steam generator water level

    Energy Technology Data Exchange (ETDEWEB)

    Arzelier, D.; Daafouz, J.; Bernussou, J.; Garcia, G

    1998-06-01

    The steam generator water level, (SGWL), control problem in the pressurized water reactor of a nuclear power plant is considered from robust control techniques point of view. The plant is a time-varying system with a non minimum phase behavior and an unstable open-loop response. The time-varying nature of the plant due to change in operating power is taken into account by including slowly time-varying uncertainty in the model. A linear Time-Invariant, (LTI) guaranteed cost quadratic stabilizing controller is designed in order to address some of the particular issues arising for such a control problem. (author) 17 refs.

  8. Matching business-level strategic controls to strategy: Impact on control system effectiveness

    National Research Council Canada - National Science Library

    Fiegener, Mark K

    1994-01-01

    ... if they are to lead their organizations toward long-term strategic objectives. The contingent relationships between strategic control, business-level strategy, and the perceived effectiveness of the strategic control system are explored...

  9. Boiler level control system based on ControlLogix5550 PLC

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>This paper is a research design based on EFPT process control device.In the design,actual industry field has been simulated and corresponding modelling has been carried on for the boiler level system.Then the appropriate PID parameter has been sorted out and ControlLogix5550 PLC has been used to control the entire boiler level system. At last,a corresponding control interface has been established and the boiler level has been under a safe and accurate control.

  10. Tomography vs quantum control for a three-level atom

    Energy Technology Data Exchange (ETDEWEB)

    Aguilar, O. [Departamento de Fisica, Universidad de Guadalajara, Revolucion 1500, 44420 Guadalajara, Jalisco (Mexico)]. E-mail: caronte30@yahoo.com; Klimov, A.B. [Departamento de Fisica, Universidad de Guadalajara, Revolucion 1500, 44420 Guadalajara, Jalisco (Mexico); Guise, Hubert de [Department of Physics, Lakehead University, Thunder Bay, Ontario P7B 5E1 (Canada)

    2006-12-04

    We investigate the possibilities of controlling and reconstructing the state of a single three-level atom. We propose a physical scheme where information about the atomic state is extracted by measuring the total number of excitations after successive application of electromagnetic field pulses. We show that, in the non-degenerate case (different transition frequencies for different atomic transitions), a three-level atom is completely controllable and its state can be completely reconstructed. In the degenerate case (when both atomic transitions are identical), we consider two dynamically inequivalent configurations, {lambda} and {xi}. In this case, we show that the density matrix can always be completely reconstructed whereas their respective system cannot be completely controlled. We explain why this last incompatibility between control and tomography arises.

  11. Level measurement and control strategies for subsea separators

    Science.gov (United States)

    Hjertaker, Bjorn T.; Johansen, Geir A.; Jackson, Peter

    2001-07-01

    Level monitoring instrumentation is an essential part of hydrocarbon processing facilities, and has, together with separator technology, been widely addressed over the last decade. Key issues are production capacity, product enhancement, and well-flow control. The reliability and accuracy of the level instrumentation, and its ability to monitor all the interface layers of the separator, including the thickness of the foam and the oil-water emulsion, are particularly important when considering the level instrumentation as the main sensing element in the automatic control of the separator vessel. Lately, industry focus has been placed on optimal automatic control to improve the quality of the production output, and to minimize the use of expensive and environmentally undesirable separation enhancing chemicals. Recent developments in hydrocarbon production include subsea separation stations, where the constraints placed on the reliability and accuracy of the level instrumentation are especially demanding. This paper presents level interface monitoring developments based on electrical, ultrasonic, thermal, and nucleonic physical principles for three-phase hydrocarbon separators, and introduces the notion of tomometry, meaning multi-point cross-sectional metering aiming to acquire information on the cross-sectional flow-component distribution in the process vessel intended for control purposes.

  12. SNS Low-Level RF Control System Design and Performance

    CERN Document Server

    Ma, Hengjie; Crofford, Mark; Doolittle, Lawrence; Kasemir, Kay-Uwe; Piller, Maurice; Ratti, Alessandro

    2005-01-01

    A full digital Low-Level RF controller has been developed for SNS LINAC. Its design is a good example of a modern digital implementation of the classic control theory. The digital hardware for all the control and DSP functionalities, including the final vector modulation, is implemented on a single high-density FPGA. Two models for the digital hardware have been written in VHDL and Verilog respectively, based on a very low latency control algorithm, and both have been being used for supporting the testing and commissioning the LINAC to the date. During the commissioning, the flexibility and ability for precise controls that only digital design on a larger FPGA can offer has proved to be a necessity for meeting the great challenge of a high-power pulsed SCL.

  13. Reprogrammable Controller Design From High-Level Specification

    Directory of Open Access Journals (Sweden)

    M. Benmohammed

    2003-10-01

    Full Text Available Existing techniques in high-level synthesis mostly assume a simple controller architecture model in the form of a single FSM. However, in reality more complex controller architectures are often used. On the other hand, in the case of programmable processors, the controller architecture is largely defined by the available control-flow instructions in the instruction set. With the wider acceptance of behavioral synthesis, the application of these methods for the design of programmable controllers is of fundamental importance in embedded system technology. This paper describes an important extension of an existing architectural synthesis system targeting the generation of ASIP reprogrammable architectures. The designer can then generate both style of architecture, hardwired and programmable, using the same synthesis system and can quickly evaluate the trade-offs of hardware decisions.

  14. Controlling a d-level atom in a cavity

    Energy Technology Data Exchange (ETDEWEB)

    Keyl, Michael [TU Muenchen, Fakultaet Mathematik, 85748 Garching (Germany)

    2016-07-01

    In this talk we discuss quantum control theory for a d-level atom in a cavity. The atom is described by a Graph Γ with energy levels as vertices and edges e as allowed transitions. For each such e the atom interacts (via a Jaynes-Cummings like interaction term) with a different mode of the cavity. We consider controllability of the overall system (i.e. atom and cavity) under the assumption that all atom-cavity interactions can be switched on and off individually and that the atom itself is fully controllable. Our main tools are symmetry based arguments recently introduced for the discussion of the two-level case. The basic idea is to divide the control Hamiltonians into two sets. One which is invariant under the action of an Abelian symmetry group G and a second set which breaks this symmetry. We will discuss how the group G and its action are related to the graph Γ and its fundamental groupoid, and how these structure can be used to prove full controllability - at least if Γ is acyclic. For Graphs containing cycles the situation is more difficult and the universal covering graph has to be used. We demonstrate this, using the fully connected graph on three vertices as an example.

  15. Many levels of control of V gene rearrangement frequency.

    Science.gov (United States)

    Feeney, Ann J; Goebel, Peter; Espinoza, Celia R

    2004-08-01

    V, D, and J gene segments rearrange at very different frequencies. As with most biological systems, there are multiple levels of control of V gene recombination frequency, and here we review some of the work from our laboratory that addresses these various control mechanisms. One of the important factors that affect non-random V gene rearrangement frequency is the natural heterogeneity in recombination signal sequences (RSSs). Not only does variation in the heptamer and nonamer affect rearrangement, but variation in the spacer can also dramatically affect recombination. However, there are clearly other factors which control V gene rearrangement, as revealed by the fact that genes with identical RSSs can rearrange at different frequencies in vivo. Some of these other influences most likely affect the earliest stages of control--the change from an inaccessible state to an accessible state. Transcription factors can play a role in inducing these changes. Rearrangement of many VkappaI genes can be induced in a non-lymphoid cell line after ectopic expression of E2A, while neighboring VkappaII and VkappaIII genes do not rearrange, demonstrating that at least one level of control of induction of accessibility occurs at the level of the individual gene. Also, changes in chromatin structure can affect accessibility and might influence individual V gene rearrangement frequency.

  16. A mild method of amine-type adsorbents syntheses with emulsion graft polymerization of glycidyl methacrylate on polyethylene non-woven fabric by pre-irradiation

    Science.gov (United States)

    Ma, Hongjuan; Yao, Side; Li, Jingye; Cao, Changqing; Wang, Min

    2012-09-01

    A mild pre-irradiation method was used to graft glycidyl methacrylate (GMA) onto polyethylene (PE) non-woven fabric (NF). The polymer was irradiated by electron beam in air atmosphere at room temperature. The degree of grafting (Dg) was determined as a function of reaction time, absorbed dose, monomer concentration and temperature. After 30 kGy irradiation, with 5% GMA, surfactant Tween 20 (Tw-20) of 0.5% at 55 °C for 15 min, the trunk polymer was made grafted with a Dg of 150%. Selected PE-g-PGMA of different Dg was modified with aminated compounds such as ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and tetraethylenepentamine (TEPA). The obtained amine-type adsorbents were prepared to remove copper and uranium ions from solution. It was shown that at least 90% of copper and 60% of uranium with the initial concentration from 3 to 1000 ppb can be removed from water.

  17. Preirradiation Graft Polymerization of Styrene in a Poly(tetrafluoroethylene Film Investigated by Time-Resolved Small-Angle Neutron Scattering

    Directory of Open Access Journals (Sweden)

    Hiroki Iwase

    2011-01-01

    Full Text Available Preirradiation graft polymerization of styrene in a poly(tetrafluoroethylene (PTFE film was examined by time-resolved small-angle neutron scattering (SANS. A crosslinked PTFE film, thickness of which is about 50 μm, was irradiated by γ-ray and immersed in a mixed solvent of styrene monomer and toluene. SANS elucidated that graft polymerization proceeds by two reaction processes (I and (II. In process (I at 0<<200 min, graft polymerization occurs at an interface between crystalline and amorphous PTFE domains and the grafted polystyrene segregates from PTFE, forming a thin layer with a sharp interface. In process (II at 200<<600 min, grafted PS layer starts to bridge between crystalline domains. At the end of process (II, 40% of total crystalline PTFE domain is covered by the grafted PS chains.

  18. [Knowledge level of hypertensive patients about hypertension. Relationship between knowledge level and hypertension control].

    Science.gov (United States)

    Benítez Camps, M; Egocheaga Cabello, M Isabel; Dalfó Baqué, A; Bajo García, J; Vara González, L; Sanchis Doménech, C; Martín Rioboo, E; Ureña Fernández, T; Domínguez Sardiña, M; Bonet Pla, A

    2015-01-01

    To assess the knowledge of the hypertensive patients about their hypertension and their relation to its control. Cross-sectional study among 400 hypertensive patients, all over 18 years, selected from 50 primary-care centres, who responded to an hypertension-related survey. Included variables were survey items, age, gender, educational level, professional occupation, blood pressure data and antihypertensive treatment. The obtained differences were analyzed using the chi-square test, Kruskal-Wallis, Wilcoxon, Anova and Bonferroni methods. There were 323 valid surveys. 52.9% of respondents were women, the average age: 65.4 years (SD: 11.2), 54.8% of them had primary education. 39.6% were aware of the objectives of systolic BP control. Only 19.6% having knowledge of those for diastolic BP control, with no differences between controlled and uncontrolled (systolic BP: 39% vs 38.1%, P=.887; diastolic BP: 19.2% vs 21%, P=.721). Over 70% knew about lifestyle changes, without significant differences between controlled and uncontrolled respondents. 82% of controlled respondents, and 79% of those uncontrolled, recognized the chronical nature of the treatment (P=.548), but 15.1% of the controlled respondents and 12.4% of uncontrolled respondents did not see the relation between the treatment and hypertension control (P=.525). 31.1% believed to be well-controlled, but in fact was not. Our patients doesn't know blood pressure targets of control. There isn't relationship between this knowledge and control of hypertension. Copyright © 2014 SEHLELHA. Published by Elsevier Espana. All rights reserved.

  19. Impact of HVAC control improvements on supermarket humidity levels

    Energy Technology Data Exchange (ETDEWEB)

    Khattar, M.; Henderson, H.I. Jr.

    1999-07-01

    This paper presents field-monitored data from two supermarkets where the impact of implementing minor HVAC control improvements was evaluated. The control improvements were intended to increase the dehumidification capacity of the HVAC system and lower space humidity levels. Direct digital control (DDC) was installed at each store to monitor system performance and implement the control improvements. At the first test store, a 33,400 ft{sup 2} (3,104 m{sup 2}) supermarket near Minneapolis, a conventional 50 ton (176 kW) split system conditioned the sales area. At the second store, a 50,000 ft{sup 2} (4,647 m{sup 2}{minus}) supermarket near Indianapolis, three rooftop units (RTUs) with a total capacity of 98 tons (344 kW) conditioned the store. The results from both supermarkets confirm the impact that supply airflow and part-load control of evaporator coil temperatures can have on dehumidification performance. Seemingly minor control adjustments can often have a big impact on the performance of supermarket HVAC systems. Even enhanced dehumidification technologies, such as heat pipe-assisted evaporator coils, can benefit from minor system tuning.

  20. Intelligent supervisory-level control of industrial processes

    Energy Technology Data Exchange (ETDEWEB)

    Jaervensivu, M. [Pronyx Control Software (Finland); Juuso, E. [Oulu Univ. (Finland). Control Engineering Lab.

    2000-07-01

    Faced by intense competition, the pulp and paper industry is aiming for higher profitability by raising productivity and lowering costs. On the global scale, the industry has to meet increasing market demands for higher product quality, more specialty products, greater production flexibility and a higher standard of environmental protection. For these reasons, extensive research is being conducted to improve existing processes. One option that is gaining increasing attention within the industry is to improve control of existing processes by means of intelligent systems. In this paper, an intelligent kiln control system is presented. The system consists of two parts: the stabilizing control is based on a new LECont concept which uses a novel linguistic equation approach, while the targets are determined by a StabOpti concept on the optimisation level. Nonlinear models obtained from process data are used for optimisation and compensation of load disturbances. According to test results from on industrial pulp mill, operational flexibility was improved and both economic and ecological benefits were obtained. The overall control system provides a better insight into the process and extends the scope of both fuzzy logic control and advanced extensions of classical control. (orig.)

  1. CHOLESTEROL LEVELS AND SUICIDAL BEHAVIOR: A CASE CONTROL STUDY

    Directory of Open Access Journals (Sweden)

    Nikhil

    2014-06-01

    Full Text Available BACKGROUND: In modern psychiatry, there is a movement to understand mental health, not solely based on behaviors and subjective report, but also based on objective markers of illness. Several studies have focused on a relationship between serum cholesterol levels and aggressive behaviors including suicide. AIM: To identify a potential link between cholesterol and suicidal behavior. MATERIAL AND METHODS: 150 patients with psychiatry diagnosis were divided into three equal groups (50 each: those who had a recent suicidal attempt, those who had suicidal ideations but no attempts and those with psychiatry diagnosis but no suicidal ideations and attempts. Blood sample for total cholesterol level was on IPD or OPD basis. The study was started after taking approval from institute ethical committee. Analysis was done using Chi square test. OBSERVATIONS AND RESULTS: It was found that maximum patients who attempted suicide belonged to major depression and schizophrenia followed by substance dependence and bipolar affective disorder (BPAD with major depression and there was statistical difference in cholesterol levels of patients with suicide attempt, with suicidal ideations and control group. 42% and 44% of major depression and schizophrenia cases respectively had low total serum cholesterol levels (below 160 mg%. CONCLUSION: There is a potential link between serum total cholesterol levels and suicidal behavior. Taking the literature as a whole there is substantial evidence that low cholesterol levels are found in suicidal behaviors of various psychiatric illnesses especially major depressive disorder, schizophrenia, substance dependence and bipolar depressive disorder

  2. Backstepping controller of five-level three-phase inverter

    Directory of Open Access Journals (Sweden)

    Majdoul R.

    2014-01-01

    Full Text Available Multilevel converters are becoming increasingly used in many industrial applications due to the many advantages that they offer. The improvements in the output signal quality, lower Total Harmonic Distortion (THD and many other properties make multilevel converters very attractive for connecting photovoltaic generators to medium voltage grid directly or to be used in a local power supply. In this paper, we focus on the implementation of a three-phase five-level diode clamped inverter and design of a performing nonlinear controller using the Backstepping approach. The control objective is to generate, at the system output, sinusoidal three-phase voltages with amplitude and frequency fixed by the reference signal independently of load variations. The performance study of the multilevel inverter and the designed controller are made by simulations in Matlab/Simulink environment.

  3. P controller with partial feed forward compensation and decoupling control for the steam generator water level

    Energy Technology Data Exchange (ETDEWEB)

    Liu Cheng, E-mail: liuch_2004@stu.xjtu.edu.c [School of Energy and Power Engineering, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China); Zhao Fuyu; Hu Ping; Hou Suxia; Li Chong [School of Energy and Power Engineering, Xi' an Jiaotong University, Xi' an, Shaanxi 710049 (China)

    2010-01-15

    In this paper, a P controller with partial feed forward compensation and decoupling control for the steam generator water level is presented. While taking the steam flowrate as a disturbance to water level, the controller design can be completed in three stages. (1) Main circuit controller is designed without regard to disturbance. Since the transfer function of the steam generator model contains integrate element and differential element, the proportional (P) controller can selected as main circuit controller instead of PID controller for steam generator water level. (2) Partial feed forward compensation is introduced to remove the disturbance from the steam flowrate. If disregarding the differential element, the partial feed forward compensation's designing turns to be very simple. Partial feed forward compensation coefficient is set as reciprocal of P controller gain. (3) The coupling effects between the water level regulating and steam flowrate disturbance can be decreased by model reference decoupling control. The proposed methodology shows satisfactory transient responses, disturbance rejection and robustness.

  4. Control of cyclin C levels during development of Dictyostelium.

    Directory of Open Access Journals (Sweden)

    David M Greene

    Full Text Available BACKGROUND: Cdk8 and its partner cyclin C form part of the mediator complex which links the basal transcription machinery to regulatory proteins. The pair are required for correct regulation of a subset of genes and have been implicated in control of development in a number of organisms including the social amoeba Dictyostelium discoideum. When feeding, Dictyostelium amoebae are unicellular but upon starvation they aggregate to form a multicellular structure which develops into a fruiting body containing spores. Cells in which the gene encoding Cdk8 has been deleted fail to enter aggregates due to a failure of early gene expression. PRINCIPAL FINDINGS: We have monitored the expression levels of cyclin C protein during development and find levels decrease after the multicellular mound is formed. This decrease is triggered by extracellular cAMP that, in turn, is working in part through an increase in intracellular cAMP. The loss of cyclin C is coincident with a reduction in the association of Cdk8 with a high molecular weight complex in the nucleus. Overexpression of cyclin C and Cdk8 lead to an increased rate of early development, consistent with the levels being rate limiting. CONCLUSIONS: Overall these results show that both cyclin C and Cdk8 are regulated during development in response to extracellular signals and the levels of these proteins are important in controlling the timing of developmental processes. These findings have important implications for the role of these proteins in controlling development, suggesting that they are targets for developmental signals to regulate gene expression.

  5. Vision-based level control for beverage-filling processes

    Science.gov (United States)

    Ley, Dietmar; Braune, Ingolf

    1994-11-01

    This paper presents a vision-based on-line level control system which is used in beverage filling machines. Motivation for the development of this sensor system was the need for an intelligent filling valve, which can provide constant filling levels for all container/product combinations (i.e. juice, milk, beer, water, etc. in glass or PET bottles with various transparency and shape) by using a non-tactile and completely sterile measurement method. The sensor concept being presented in this paper is based on several CCD-cameras imaging the moving containers from the outside. The stationary lighting system illuminating the bottles is located within the filler circle. The field of view covers between 5 and 8 bottles depending on the bottle diameter and the filler partitioning. Each filling element's number is identified by the signals of an angular encoder. The electro-pneumatic filling valves can be opened and closed by computer control The cameras continuously monitor the final stages of the filling process, i.e. after the filling height has reached the upper half of the bottle. The sensor system measures the current filling height and derives the filling speed. Based on static a priori- knowledge and dynamic process knowledge the sensor system generates a best estimate of the particular time when the single valve is to be closed. After every new level measurement the system updates the closing time. The measurement process continues until the result of the next level calculation would be available after the estimated closing time would have been passed. The vision-based filling valve control enables the filling machine to adapt the filling time of each valve to the individual bottle shape. Herewith a standard deviation between 2 and 4 mm (depending on the slew rate in the bottle neck) can be accomplished, even at filling speed > 70.000 bottles per hour. 0

  6. Inventory Control by Multiple Service Levels under Unreliable Supplying Condition

    Directory of Open Access Journals (Sweden)

    Byungsoo Na

    2016-01-01

    Full Text Available We consider an inventory system where there is random demand from customers as well as unreliable supplying capacity from supplier. In many real-world cases, supplier might fail to satisfy the amount of order from retailers or producers so that only partial proportion of order is satisfied or even fail to deliver all of the order. Moreover, recently a concern regarding unreliable supplying capacity has been increasing since the globalization makes the retailer or producer face the extended supply network with complicated and risky supplying capacity. Also, we consider two classified customers, of which one is willing to pay extra charge for expedited delivery service but the other is not reluctant to delay the delivery without any extra charge. We show that there exists an optimal threshold for inventory and price for each service level in the following sense: if the inventory level is less than the predetermined threshold, then the retailer or producer needs to order up to the threshold level and offer threshold price corresponding to service level. Otherwise, the retailer does not need to order. The risk of stockout due to unreliable supplying capacity can be mitigated by the dynamic pricing and inventory control with multiple service levels.

  7. An Hybrid Multi Level Inverter Based on DSTATCOM Control

    Directory of Open Access Journals (Sweden)

    K. Ramash Kumar

    2011-06-01

    Full Text Available This paper presents an investigation on the Hybrid Seven-Level (HSL H–bridge inverter, which is used in a Distribution Static Compensator (DSTATCOM in Power Systems (PS. Making use of HSLI has the benefits of low harmonics distortion, reduced number of switches required to achieve the seven- level inverter output over the conventional cascaded seven-level inverter, and also reduced switching losses. In order to compensate the reactive power and suppress the total harmonics distortion (THD drawn from a Non-Liner Diode Rectifier Load (NLDRL of DSTATCOM, we propose a Sub-Harmonics Pulse Width Modulation (SHPWM technique to control the switches of HSL H – bridge inverter. The D-Q reference frame theory is used to generate the reference compensating currents for DSTATCOM and proportional and integral (PI control is used for capacitors dc voltage regulation for DSTATCOM. An HSL H–bridge inverter is considered for the shunt compensation of a 4.5 kV distribution system. The results are validated by MatLab/Simulink simulation software.

  8. Control levels of acetylcholinesterase expression in the mammalian skeletal muscle.

    Science.gov (United States)

    Grubic, Z; Zajc-Kreft, K; Brank, M; Mars, T; Komel, R; Miranda, A F

    1999-05-14

    Protein expression can be controled at different levels. Understanding acetylcholinesterase (EC. 3.1.1.7, AChE) expression in the living organisms therefore necessitates: (1) determination and mapping of control levels of AChE metabolism; (2) identification of the regulatory factors acting at these levels; and (3) detailed insight into the mechanisms of action of these factors. Here we summarize the results of our studies on the regulation of AChE expression in the mammalian skeletal muscle. Three experimental models were employed: in vitro innervated human muscle, mechanically denervated adult fast rat muscle, and the glucocorticoid treated fast rat muscle. In situ hybridization of AChE mRNA, combined with AChE histochemistry, revealed that different distribution patterns of AChE, observed during in vitro ontogenesis and synaptogenesis of human skeletal muscle, reflect alterations in the distribution of AChE mRNA (Z. Grubic, R. Komel, W.F. Walker, A.F. Miranda, Myoblast fusion and innervation with rat motor nerve alter the distribution of acetylcholinesterase and its mRNA in human muscle cultures, Neuron 14 (1995) 317-327). To study the mechanisms of AChE mRNA loss in denervated adult rat skeletal muscle, we exposed deproteinated AChE mRNA to various subcellular fractions in vitro. Fractions were isolated from the normal and denervated rat sternomastoideus muscle. We found significantly increased, but non-specific AChE mRNA degradation capacities in the three fractions studied, suggesting that increased susceptibility of muscle mRNA to degradation might be at least partly responsible for the decreased AChE mRNA observed under such conditions (K. Zajc-Kreft, S. Kreft, Z. Grubic, Degradation of AChE mRNA in the normal and denervated rat skeletal muscle, Book of Abstracts, The Sixth International Meeting on Cholinesterases, La Jolla, CA, March 20-24, 1998, p. A3.). In adult fast rat muscle, treated chronically with glucocorticoids, we found the fraction of early

  9. Control of quality in spectrometry gamma of low level

    CERN Document Server

    Salazar, A

    1997-01-01

    Low level gamma spectrometry is a very precise technique to measure the concentration of nuclides present in different samples in Bq kg sup - sup 1. The quality control of the procedure and method used can be carried out by intercomparison exercises with world recognized institutions. During the last three years the Nuclear Physics Laboratory Of The University of Costa Rica (LAFNA) has been participating in the international quality assessment program (QAP) carried out by the Environmental Measurements Laboratory (EML), department of Energy, USA. The results show a very good agreement with the rest of the participant laboratories. This provides a very objective evaluation of the high precision of the methods used by LAFNA in low level spectroscopy measurements. (Author)

  10. Controls on Precambrian sea level change and sedimentary cyclicity

    Science.gov (United States)

    Eriksson, P. G.; Catuneanu, O.; Nelson, D. R.; Popa, M.

    2005-04-01

    Although uniformitarianism applies in a general sense to the controls on relative and global sea level change, some influences thereon were more prominent in the Precambrian. Short-term base level change due to waves and tides may have been enhanced due to possibly more uniform circulation systems on wide, low gradient Precambrian shelves. The lack of evidence for global glacial events in the Precambrian record implies that intraplate stresses and cyclic changes to Earth's geoid were more likely explanations for third-order sea level change than glacio-eustasy. Higher heat flow in the earlier Precambrian may have led to more rapid tectonic plate formation, transport and destruction, along with an increased role for hot spots, aseismic ridges and mantle plumes (superplumes), all of which may have influenced cyclic sedimentation within the ocean basins. A weak cyclicity in the occurrence of plume events has an approximate duration comparable to that of first-order (supercontinental cycle) sea level change. Second-order cyclicity in the Precambrian largely reflects the influences of thermal epeirogeny, changes to mid-ocean ridge volume as well as to ridge growth and decay rates, and cratonic marginal downwarping concomitant with either sediment loading or extensional tectonism. Third-order cycles of sea level change in the Precambrian also reflected cyclic loading/unloading within flexural foreland basin settings, and filling/deflation of magma chambers associated with island arc evolution. The relatively limited number of studies of Precambrian sequence stratigraphy allows some preliminary conclusions to be drawn on duration of the first three orders of cyclicity. Archaean greenstone basins appear to have had first- and second-order cycle durations analogous to Phanerozoic equivalents, supporting steady state tectonics throughout Earth history. In direct contrast, however, preserved basin-fills from Neoarchaean-Palaeoproterozoic cratonic terranes have first- and

  11. Soft Computing Technique and Conventional Controller for Conical Tank Level Control

    Directory of Open Access Journals (Sweden)

    Sudharsana Vijayan

    2016-03-01

    Full Text Available In many process industries the control of liquid level is mandatory. But the control of nonlinear process is difficult. Many process industries use conical tanks because of its non linear shape contributes better drainage for solid mixtures, slurries and viscous liquids. So, control of conical tank level is a challenging task due to its non-linearity and continually varying cross-section. This is due to relationship between controlled variable level and manipulated variable flow rate, which has a square root relationship. The main objective is to execute the suitable controller for conical tank system to maintain the desired level. System identification of the non-linear process is done using black box modelling and found to be first order plus dead time (FOPDT model. In this paper it is proposed to obtain the mathematical modelling of a conical tank system and to study the system using block diagram after that soft computing technique like fuzzy and conventional controller is also used for the comparison.

  12. Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission

    Directory of Open Access Journals (Sweden)

    Nadine Erlenhardt

    2016-02-01

    Full Text Available AMPA receptor (AMPAR complexes contain auxiliary subunits that modulate receptor trafficking and gating. In addition to the transmembrane AMPAR regulatory proteins (TARPs and cornichons (CNIH-2/3, recent proteomic studies identified a diverse array of additional AMPAR-associated transmembrane and secreted partners. We systematically surveyed these and found that PORCN and ABHD6 increase GluA1 levels in transfected cells. Knockdown of PORCN in rat hippocampal neurons, which express it in high amounts, selectively reduces levels of all tested AMPAR complex components. Regulation of AMPARs is independent of PORCN’s membrane-associated O-acyl transferase activity. PORCN knockdown in hippocampal neurons decreases AMPAR currents and accelerates desensitization and leads to depletion of TARP γ-8 from AMPAR complexes. Conditional PORCN knockout mice also exhibit specific changes in AMPAR expression and gating that reduce basal synaptic transmission but leave long-term potentiation intact. These studies define additional roles for PORCN in controlling synaptic transmission by regulating the level and composition of hippocampal AMPAR complexes.

  13. Switched Quantization Level Control of Networked Control Systems with Packet Dropouts

    Directory of Open Access Journals (Sweden)

    Shuo Wang

    2014-01-01

    Full Text Available This paper investigates the relationship between the maximum allowable dropout bound and the quantization density. Networked Control System (NCS is described as a time-delay switched system with constrained switching signals. A switched dynamic output feedback controller with prescribed disturbance attenuation level is designed via a cone complement linearization approach. A novel stability criterion is obtained by switched system theory. Furthermore, finding an appropriate quantization density used when packet dropout occurs is converted to an optimization problem.

  14. An invisible axion model with controlled FCNCs at tree level

    Directory of Open Access Journals (Sweden)

    Alejandro Celis

    2015-02-01

    Full Text Available We derive the necessary conditions to build a class of invisible axion models with Flavor Changing Neutral Currents at tree-level controlled by the fermion mixing matrices and present an explicit model implementation. A horizontal Peccei–Quinn symmetry provides a solution to the strong CP problem via the Peccei–Quinn mechanism and predicts a cold dark mater candidate, the invisible axion or familon. The smallness of active neutrino masses can be explained via a type I seesaw mechanism, providing a dynamical origin for the heavy seesaw scale. The possibility to avoid the domain wall problem stands as one of the most interesting features of the type of models considered. Experimental limits relying on the axion–photon coupling, astrophysical considerations and familon searches in rare kaon and muon decays are discussed.

  15. An invisible axion model with controlled FCNCs at tree level

    Energy Technology Data Exchange (ETDEWEB)

    Celis, Alejandro, E-mail: alejandro.celis@ific.uv.es [Departament de Física Teòrica and IFIC, Universitat de València-CSIC, E-46100, Burjassot (Spain); Fuentes-Martín, Javier, E-mail: javier.fuentes@ific.uv.es [Departament de Física Teòrica and IFIC, Universitat de València-CSIC, E-46100, Burjassot (Spain); Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); Serôdio, Hugo, E-mail: hserodio@kaist.ac.kr [Departament de Física Teòrica and IFIC, Universitat de València-CSIC, E-46100, Burjassot (Spain); Department of Physics, Korea Advanced Institute of Science and Technology, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701 (Korea, Republic of)

    2015-02-04

    We derive the necessary conditions to build a class of invisible axion models with Flavor Changing Neutral Currents at tree-level controlled by the fermion mixing matrices and present an explicit model implementation. A horizontal Peccei–Quinn symmetry provides a solution to the strong CP problem via the Peccei–Quinn mechanism and predicts a cold dark mater candidate, the invisible axion or familon. The smallness of active neutrino masses can be explained via a type I seesaw mechanism, providing a dynamical origin for the heavy seesaw scale. The possibility to avoid the domain wall problem stands as one of the most interesting features of the type of models considered. Experimental limits relying on the axion–photon coupling, astrophysical considerations and familon searches in rare kaon and muon decays are discussed.

  16. Optimal control of multi-level quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Robert M.

    2010-12-02

    This thesis is concerned with the control of quantum systems. Given a Hamiltonian model of a quantum system, we are interested in finding controls - typically shaped electromagnetic pulses - that steer the evolution of the system toward a desired target operation. For this we employ a numerical optimisation method known as the GRAPE algorithm. For particular experimental systems, we design control schemes that respect constraints of robustness and addressability, and are within the reach of the experimental hardware. A general procedure is given for specifying a Hamiltonian model of a driven N-level system and converting it to an appropriate rotating frame. This is then applied together with the numerical algorithm to design improved schemes for two different systems, where laser fields manipulate orbital and hyperfine states of Pr{sup 3+} and Rb. The generation of cluster states in Ising-coupled systems is also studied. We find that, in the ideal case, the solution of evolving only under the coupling Hamiltonian is not time-optimal. This surprising result is in contrast to the known cases for unitary gates. For a symmetrised three-qubit example, we provide a geometrical interpretation of this. Numerically optimised control schemes are then developed for a nonideal coupling topology, modelling an experimental configuration of trapped ions. Controls for the implementation of the two-qubit Deutsch and Grover algorithms are designed for a pair of {sup 13}C nuclear spins at a nitrogen vacancy center in diamond. These implementations are robust to experimental errors, and found to be reproduced with high accuracy on a VFG-150 pulse generator. We also consider two-qubit gate synthesis in a system of superconducting qubits coupled by microwave resonators known as the cavity grid. We find that the optimised schemes allow two-qubit operations to be performed between an arbitrary qubit pair on the grid with only a small time overhead, with speedups of 2-4 over the existing

  17. Levels of control and closure in complex semiotic systems

    Science.gov (United States)

    Joslyn

    2000-01-01

    It is natural to advance closures as atomic processes of universal evolution, and to analyze this concept specifically. Real complex systems like organisms and complex mechanisms cannot exist at either extreme of complete closure or lack of closure, nevertheless we should consider the properties of closures in general, the introduction of boundaries, a corresponding stability, the establishment of system autonomy and identity, and thereby the introduction of emergent new system of potentially new types. Our focus should move from simple physical closure of common objects and classical self-organizing systems to semiotically closed systems that maintain cyclic relations of perception, interpretation, decision, and action with their environments. Thus, issues arise concerning the use and interpretation of symbols, representations, and/or internal models (whether explicit or implicit) by the system; and the syntactic, semantic, and pragmatic relations among the sign tokens, their interpretations, and their use or function for the systems in question. Primitive semiotic closures are hypothesized as equivalent to simple control systems, and in turn equivalent to simple organisms. This leads us directly to the grand hierarchical control theories of Turchin, Powers, and Albus, which provide an explicit mechanism for the formation of new levels within complex semiotically closed systems.

  18. LOWER LEVEL INFERENCE CONTROL IN STATISTICAL DATABASE SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Lipton, D.L.; Wong, H.K.T.

    1984-02-01

    An inference is the process of transforming unclassified data values into confidential data values. Most previous research in inference control has studied the use of statistical aggregates to deduce individual records. However, several other types of inference are also possible. Unknown functional dependencies may be apparent to users who have 'expert' knowledge about the characteristics of a population. Some correlations between attributes may be concluded from 'commonly-known' facts about the world. To counter these threats, security managers should use random sampling of databases of similar populations, as well as expert systems. 'Expert' users of the DATABASE SYSTEM may form inferences from the variable performance of the user interface. Users may observe on-line turn-around time, accounting statistics. the error message received, and the point at which an interactive protocol sequence fails. One may obtain information about the frequency distributions of attribute values, and the validity of data object names from this information. At the back-end of a database system, improved software engineering practices will reduce opportunities to bypass functional units of the database system. The term 'DATA OBJECT' should be expanded to incorporate these data object types which generate new classes of threats. The security of DATABASES and DATABASE SySTEMS must be recognized as separate but related problems. Thus, by increased awareness of lower level inferences, system security managers may effectively nullify the threat posed by lower level inferences.

  19. Fast wafer-level detection and control of interconnect reliability

    Science.gov (United States)

    Foley, Sean; Molyneaux, James; Mathewson, Alan

    2000-08-01

    Many of the technological advances in the semiconductor industry have led to dramatic increases in device density and performance in conjunction with enhanced circuit reliability. As reliability is improved, the time taken to characterize particular failure modes with traditional test methods is getting substantially longer. Furthermore, semiconductor customers expect low product cost and fast time-to-market. The limits of traditional reliability testing philosophies are being reached and new approaches need to be investigated to enable the next generation of highly reliable products to be tested. This is especially true in the area of IC interconnect, where significant challenges are predicted for the next decade. A number of fast, wafer level test methods exist for interconnect reliability evaluation. The relative abilities of four such methods to detect the quality and reliability of IC interconnect over very short test times are evaluated in this work. Four different test structure designs are also evaluated and the results are bench-marked against conventional package level Median Time to Failure results. The Isothermal test method combine with SWEAT-type test structures is shown to be the most suitable combination for defect detection and interconnect reliability control over very short test times.

  20. Application of a pilot control banding tool for risk level assessment and control of nanoparticle exposures

    Energy Technology Data Exchange (ETDEWEB)

    Paik, S Y; Zalk, D M; Swuste, P

    2008-03-03

    Control Banding (CB) strategies offer simplified solutions for controlling worker exposures to constituents that are found in the workplace in the absence of firm toxicological and exposure data. These strategies may be particularly useful in nanotechnology applications, considering the overwhelming level of uncertainty over what nanomaterials and nanotechnologies present as potential work-related health risks, what about these materials might lead to adverse toxicological activity, how risk related to these might be assessed, and how to manage these issues in the absence of this information. This study introduces a pilot CB tool or 'CB Nanotool' that was developed specifically for characterizing the health aspects of working with engineered nanoparticles and determining the level of risk and associated controls for five ongoing nanotechnology-related operations being conducted at two Department of Energy (DOE) research laboratories. Based on the application of the CB Nanotool, four of the five operations evaluated in this study were found to have implemented controls consistent with what was recommended by the CB Nanotool, with one operation even exceeding the required controls for that activity. The one remaining operation was determined to require an upgrade in controls. By developing this dynamic CB Nanotool within the realm of the scientific information available, this application of CB appears to be a useful approach for assessing the risk of nanomaterial operations, providing recommendations for appropriate engineering controls, and facilitating the allocation of resources to the activities that most need them.

  1. Pre-irradiation grafting of styrene and maleic anhydride onto PVDF membrane and subsequent sulfonation for application in vanadium redox batteries

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, Jingyi; Zhai, Maolin; Ni, Jiangfeng; Zhou, Henghui; Peng, Jing; Li, Jiuqiang; Wei, Genshuan [Beijing National Laboratory for Molecular Science (BNLMS), Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China); Zhao, Long [Department of Biological and Chemical Engineering, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515 (Japan)

    2008-03-01

    A poly(vinylidene difluoride) (PVDF) membrane was grafted with styrene (St) and maleic anhydride (MAn) using an electron-beam-induced pre-irradiation grafting technique. The grafted membrane (PVDF-g-PS-co-PMAn) was then sulfonated and hydrolyzed to give an ion exchange membrane (denoted as PVDF-g-PSSA-co-PMAc) for vanadium redox flow batteries (VRB) use. Micro-FTIR analysis indicated that PVDF was successfully grafted and sulfonated at the above condition, and the membrane with a high grafting yield (GY) can be easily prepared in a St/MAn binary system at low dose due to a synergistic effect. The water uptake and ion exchange capacity (IEC) of the PVDF-g-PSSA-co-PMAc membrane increased with GY, so too did the conductivity. At a GY of 33.6%, the resulting PVDF-g-PSSA-co-PMAc membrane showed a much higher IEC and conductivity than a conventional Nafion117 membrane, and a much lower permeability of vanadium ions: ca. 1/11 to 1/16 of that through Nafion117. Open circuit voltage measurements showed that the VRB assembled with the PVDF-g-PSSA-co-PMAc membrane maintained values above 1.3 V after a period of 33 h, which was much longer than that with the Nafion117 membrane. It is expected that this work provides a new approach for the fabrication of ion exchange membranes for VRB. (author)

  2. Intelligent Platform Management Controller for Low Level RF Control System ATCA Carrier Board

    CERN Document Server

    Predki, Pawel

    2011-01-01

    High availability and reliability are among the most desirable features of control systems in modern High-Energy Physics (HEP) and other big-scale scientific experiments. One of the recent developments that has influenced this field was the emergence of the Advanced Telecommunications Computing Architecture (ATCA). Designed for the telecommunications industry it has been successfully applied in other domains such as accelerator control systems. A good example is the application of ATCA stan- dard for the design of Low Level RF (LLRF) control system for the X-Ray Free Electron Laser (XFEL) being developed in Deutsches Elektronen Synchrotron (DESY). Reliability and availability requirements for such a device play a crucial role among other parameters. Thus, the ATCA standard, with five- nines availability, is considered one of the best candidates for this system. This article focuses on the central management unit of every ATCA board, namely the Intelligent Platform Management Controller (IPMC), developed for t...

  3. Education Organization Baseline Control Protection and Trusted Level Security

    Directory of Open Access Journals (Sweden)

    Wasim A. Al-Hamdani

    2007-12-01

    Full Text Available Many education organizations have adopted for security the enterprise best practices for implementation on their campuses, while others focus on ISO Standard (or/and the National Institution of Standards and Technology.All these adoptions are dependent on IT personal and their experiences or knowledge of the standard. On top of this is the size of the education organizations. The larger the population in an education organization, the more the problem of information and security become very clear. Thus, they have been obliged to comply with information security issues and adopt the national or international standard. The case is quite different when the population size of the education organization is smaller. In such education organizations, they use social security numbers as student ID, and issue administrative rights to faculty and lab managers – or they are not aware of the Family Educational Rights and Privacy Act (FERPA – and release some personal information.The problem of education organization security is widely open and depends on the IT staff and their information security knowledge in addition to the education culture (education, scholarships and services has very special characteristics other than an enterprise or comparative organizationThis paper is part of a research to develop an “Education Organization Baseline Control Protection and Trusted Level Security.” The research has three parts: Adopting (standards, Testing and Modifying (if needed.

  4. Decrease of free thyroxine levels after controlled ovarian hyperstimulation

    NARCIS (Netherlands)

    A.F. Muller (Alex); A. Verhoeff; M.J. Mantel; F.H. de Jong (Frank); A. Berghout (Arie)

    2000-01-01

    textabstractControlled ovarian hyperstimulation could lead to opposing effects on thyroid function. Therefore, in a prospective study of 65 women undergoing controlled ovarian hyperstimulation, thyroid hormones, T4-binding globulin, TPO antibodies, gonadotropins, estrad

  5. Human-level control through deep reinforcement learning

    Science.gov (United States)

    Mnih, Volodymyr; Kavukcuoglu, Koray; Silver, David; Rusu, Andrei A.; Veness, Joel; Bellemare, Marc G.; Graves, Alex; Riedmiller, Martin; Fidjeland, Andreas K.; Ostrovski, Georg; Petersen, Stig; Beattie, Charles; Sadik, Amir; Antonoglou, Ioannis; King, Helen; Kumaran, Dharshan; Wierstra, Daan; Legg, Shane; Hassabis, Demis

    2015-02-01

    The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize their control of an environment. To use reinforcement learning successfully in situations approaching real-world complexity, however, agents are confronted with a difficult task: they must derive efficient representations of the environment from high-dimensional sensory inputs, and use these to generalize past experience to new situations. Remarkably, humans and other animals seem to solve this problem through a harmonious combination of reinforcement learning and hierarchical sensory processing systems, the former evidenced by a wealth of neural data revealing notable parallels between the phasic signals emitted by dopaminergic neurons and temporal difference reinforcement learning algorithms. While reinforcement learning agents have achieved some successes in a variety of domains, their applicability has previously been limited to domains in which useful features can be handcrafted, or to domains with fully observed, low-dimensional state spaces. Here we use recent advances in training deep neural networks to develop a novel artificial agent, termed a deep Q-network, that can learn successful policies directly from high-dimensional sensory inputs using end-to-end reinforcement learning. We tested this agent on the challenging domain of classic Atari 2600 games. We demonstrate that the deep Q-network agent, receiving only the pixels and the game score as inputs, was able to surpass the performance of all previous algorithms and achieve a level comparable to that of a professional human games tester across a set of 49 games, using the same algorithm, network architecture and hyperparameters. This work bridges the divide between high-dimensional sensory inputs and actions, resulting in the first artificial agent that is capable of learning to excel at a diverse array of challenging tasks.

  6. Human-level control through deep reinforcement learning.

    Science.gov (United States)

    Mnih, Volodymyr; Kavukcuoglu, Koray; Silver, David; Rusu, Andrei A; Veness, Joel; Bellemare, Marc G; Graves, Alex; Riedmiller, Martin; Fidjeland, Andreas K; Ostrovski, Georg; Petersen, Stig; Beattie, Charles; Sadik, Amir; Antonoglou, Ioannis; King, Helen; Kumaran, Dharshan; Wierstra, Daan; Legg, Shane; Hassabis, Demis

    2015-02-26

    The theory of reinforcement learning provides a normative account, deeply rooted in psychological and neuroscientific perspectives on animal behaviour, of how agents may optimize their control of an environment. To use reinforcement learning successfully in situations approaching real-world complexity, however, agents are confronted with a difficult task: they must derive efficient representations of the environment from high-dimensional sensory inputs, and use these to generalize past experience to new situations. Remarkably, humans and other animals seem to solve this problem through a harmonious combination of reinforcement learning and hierarchical sensory processing systems, the former evidenced by a wealth of neural data revealing notable parallels between the phasic signals emitted by dopaminergic neurons and temporal difference reinforcement learning algorithms. While reinforcement learning agents have achieved some successes in a variety of domains, their applicability has previously been limited to domains in which useful features can be handcrafted, or to domains with fully observed, low-dimensional state spaces. Here we use recent advances in training deep neural networks to develop a novel artificial agent, termed a deep Q-network, that can learn successful policies directly from high-dimensional sensory inputs using end-to-end reinforcement learning. We tested this agent on the challenging domain of classic Atari 2600 games. We demonstrate that the deep Q-network agent, receiving only the pixels and the game score as inputs, was able to surpass the performance of all previous algorithms and achieve a level comparable to that of a professional human games tester across a set of 49 games, using the same algorithm, network architecture and hyperparameters. This work bridges the divide between high-dimensional sensory inputs and actions, resulting in the first artificial agent that is capable of learning to excel at a diverse array of challenging tasks.

  7. An Implementation Mechanisms of SVM Control Strategies Applied to Five Levels Cascaded Multi-Level Inverters

    Directory of Open Access Journals (Sweden)

    Mohammed Yaichi

    2014-03-01

    Full Text Available In the area of the energy control with high voltage and power, the multilevel inverters constitute a relatively recent research orientation. The current applications of this technology are in the domains of the high voltage (over hundred kV, variable speed drives, transport and distribution of a good quality of electrical energy (HVDC, FACTS system, ..... To improve the output voltage for such inverters, many different modulation strategies have been developed. Among these strategies, the SVM (Space Vector Modulation. The technique provide the nearest switching vectors sequence to the reference vector without involving trigonometric functions and provide the additional advantages of superior harmonic quality. In this paper, we analyze different mechanisms of the output voltage synthesis and the problem of even order harmonic production. With the proposed a new trajectory SVM, which can eliminate all the even order harmonics for five levels inverter. Show clearly how to deduce the trajectories from the sequences allowing to have better performances among several possible trajectories. It is dedicated to the application of two particular trajectories.

  8. Canopy Level Solar Induced Fluorescence for Vegetation in Controlled Experiments

    Science.gov (United States)

    Middleton, E. M.; Corp, L. A.; Campbell, P. K. Entcheva

    2007-01-01

    Solar induced chlorophyll fluorescence (SIF) was retrieved from high resolution reflectance spectra acquired one meter above saplings of three deciduous tree species during springtime (three weeks after leaf flush) and in late summer when foliage was mature. SIF was determined by application of the Fraunhofer Line Depth (FLD) Principal to above-canopy spectra acquired with an Analytical Spectral Devices (ASD) Fieldspec spectroradiometer (3.2 nm resolution with 1.2 nm sampling interval). SIF retrievals were made at the two atmospheric oxygen (O2) absorption features that occur in the chlorophyll fluorescence (ChlF) region (660 -780 nm). These telluric features are 02V, the broader and deeper feature centered at 760 nm, but located on the shoulder of the far-red ChlF peak at 740 nm; and 023, a narrow feature centered at 688 nm that is positioned near the red ChlF peak at 685 nm. Supporting, coincident leaf level fluorescence, reflectance, photochemical and other measurements were also made. At the leaf level, these measurements included in situ photosynthetic capacity (Pmax) and light adapted total chlorophyll fluorescence (Fs') collected at steady state under high light and controlled chamber conditions (e.g., temperature, PAR, humidity, and COz); optical properties (reflectance, transmittance, absorptance); chlorophyll and carotenoid content; specific leaf mass; carbon (C) and nitrogen (N) content; fluorescence emission spectra at multiple excitation wavelengths; the ChlF contribution to red (R) and far-red (FR) reflectance; fluorescence imagery; and fluorescence excitation-emission matrices (EEMs). The tree species examined were tulip poplar (Liriodendron tulipifera L.), red maple (Acer rubrum L.), and sweetgum (Liquidambar styraczflua L.), and each had been provided four levels of N augmentation (0, 19, 37, and 75 kg Nhectare seasonally) to simulate atmospheric deposition from air pollution. Whole-plant SIF measurements of these species were compared with SIF

  9. Automatic Level Control for Video Cameras towards HDR Techniques

    Directory of Open Access Journals (Sweden)

    de With PeterHN

    2010-01-01

    Full Text Available We give a comprehensive overview of the complete exposure processing chain for video cameras. For each step of the automatic exposure algorithm we discuss some classical solutions and propose their improvements or give new alternatives. We start by explaining exposure metering methods, describing types of signals that are used as the scene content descriptors as well as means to utilize these descriptors. We also discuss different exposure control types used for the control of lens, integration time of the sensor, and gain control, such as a PID control, precalculated control based on the camera response function, and propose a new recursive control type that matches the underlying image formation model. Then, a description of commonly used serial control strategy for lens, sensor exposure time, and gain is presented, followed by a proposal of a new parallel control solution that integrates well with tone mapping and enhancement part of the image pipeline. Parallel control strategy enables faster and smoother control and facilitates optimally filling the dynamic range of the sensor to improve the SNR and an image contrast, while avoiding signal clipping. This is archived by the proposed special control modes used for better display and correct exposure of both low-dynamic range and high-dynamic range images. To overcome the inherited problems of limited dynamic range of capturing devices we discuss a paradigm of multiple exposure techniques. Using these techniques we can enable a correct rendering of difficult class of high-dynamic range input scenes. However, multiple exposure techniques bring several challenges, especially in the presence of motion and artificial light sources such as fluorescent lights. In particular, false colors and light-flickering problems are described. After briefly discussing some known possible solutions for the motion problem, we focus on solving the fluorescence-light problem. Thereby, we propose an algorithm for

  10. Trade Electricity. Motors & Controls--Level 3. Standardized Curriculum.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Office of Occupational and Career Education.

    This curriculum guide consists of seven modules on motors and controls, one of the three divisions of the standardized trade electricity curriculum in high schools in New York City. The seven modules cover the following subjects: energy conservation wiring, direct current (DC) motor repair and rewinding, DC motor controls, alternating current (AC)…

  11. Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: long term results of RTOG BR0131.

    Science.gov (United States)

    Vogelbaum, Michael A; Hu, Chen; Peereboom, David M; Macdonald, David R; Giannini, Caterina; Suh, John H; Jenkins, Robert B; Laack, Nadia N; Brachman, David G; Shrieve, Dennis C; Souhami, Luis; Mehta, Minesh P

    2015-09-01

    We report on the long-term results of a phase II study of pre-irradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (AO) and mixed anaplastic oligoastrocytoma. Pre-RT temozolomide was given for up to 6 cycles. RT with concurrent temozolomide was administered to patients with less than a complete radiographic response. Forty eligible patients were entered and 32 completed protocol treatment. With a median follow-up time of 8.7 years (range 1.1-10.1), median progression-free survival (PFS) is 5.8 years (95 % CI 2.0, NR) and median overall survival (OS) has not been reached (5.9, NR). 1p/19q data are available in 37 cases; 23 tumors had codeletion while 14 tumors had no loss or loss of only 1p or 19q (non-codeleted). In codeleted patients, 9 patients have progressed and 4 have died; neither median PFS nor OS have been reached and two patients who received only pre-RT temozolomide and no RT have remained progression-free for over 7 years. 3-year PFS and 6-year OS are 78 % (95 % CI 61-95 %) and 83 % (95 % CI 67-98 %), respectively. Codeleted patients show a trend towards improved 6-year survival when compared to the codeleted procarbazine/CCNU/vincristrine (PCV) and RT cohort in RTOG 9402 (67 %, 95 % CI 55-79 %). For non-codeleted patients, median PFS and OS are 1.3 and 5.8 years, respectively. These updated results suggest that the regimen of dose intense, pre-RT temozolomide followed by concurrent RT/temozolomide has significant activity, particularly in patients with 1p/19q codeleted AOs and MAOs.

  12. Expression of genes involved in mouse lung cell differentiation/regulation after acute exposure to photons and protons with or without low-dose preirradiation.

    Science.gov (United States)

    Tian, Jian; Zhao, WeiLing; Tian, Sisi; Slater, James M; Deng, Zhiyong; Gridley, Daila S

    2011-11-01

    The goal of this study was to compare the effects of acute 2 Gy irradiation with photons (0.8 Gy/min) or protons (0.9 Gy/min), both with and without pre-exposure to low-dose/low-dose-rate γ rays (0.01 Gy at 0.03 cGy/h), on 84 genes involved in stem cell differentiation or regulation in mouse lungs on days 21 and 56. Genes with a ≥1.5-fold difference in expression and P photons in modulating the genes. More genes were affected by protons than by photons (22 compared to 2 and 6 compared to 2 on day 21 and day 56, respectively) compared to 0 Gy. Preirradiation with low-dose-rate γ rays enhanced the acute photon-induced gene modulation on day 21 (11 compared to 2), and all 11 genes were significantly downregulated on day 56. On day 21, seven genes (aldh2, bmp2, cdc2a, col1a1, dll1, foxa2 and notch1) were upregulated in response to most of the radiation regimens. Immunoreactivity of Clara cell secretory protein was enhanced by all radiation regimens. The number of alveolar type 2 cells positive for prosurfactant protein C in irradiated groups was higher on day 56 (12.4-14.6 cells/100) than on day 21 (8.5-11.2 cells/100) (P photons and protons induced different gene expression profiles in the lungs and that pre-exposure to low-dose-rate γ rays sometimes had modulatory effects. In addition, proteins associated with lung-specific stem cells/progenitors were highly sensitive to radiation.

  13. In vitro hemocompatibility of sulfonated polypropylene non-woven fabric prepared via a facile γ-ray pre-irradiation grafting method

    Energy Technology Data Exchange (ETDEWEB)

    Li, Rong [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Wu, Guozhong [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); School of Physical Science and Technology, ShanghaiTech University, Shanghai 200031 (China); Ye, Yin, E-mail: yeyin@sinap.ac.cn [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2015-11-30

    Graphical abstract: - Highlights: • Sulfonated PP{sub NWF} was successfully fabricated via γ-ray pre-irradiation-induced graft polymerization of SSS method with the aid of AAm. • Compared with the pristine PP{sub NWF}, the sulfonated PP{sub NWF} material presented outstanding hydrophilicity. • The sulfonated PP{sub NWF} exhibited good hemocompatibility. - Abstract: Sulfonated polypropylene non-woven fabric (PP{sub NWF}) was successfully prepared via γ-ray pre-irradiation-induced graft polymerization of sodium styrenesulfonate (SSS) and acrylamide (AAm). The effect of pre-irradiation dose, reaction temperature, reaction time and concentration of binary monomer on the degree of grafting (DG) was studied. The chemical structure of the original and modified PP{sub NWF} materials were investigated by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) to confirm the successful introduction of sulfonated (−SO{sub 3}{sup −}) group. The wettability was examined via measurement of de-ionized water adsorption percentage, which demonstrated that the hydrophilicity of PP{sub NWF} was greatly enhanced after graft modification. A little amount of bovine serum albumin (BSA) adsorption and nearly no platelet adhesion on the surface of modified PP{sub NWF} and low hemolytic ratio of the modified PP{sub NWF} revealed that the sulfonated PP{sub NWF} exhibited good hemocompatibility. Besides, blood clotting time measurement indicated that the anticoagulant property of PP{sub NWF} was effectively enhanced via SSS modification. Consequently, the hydrophilicity, in vitro hemocompatibility and anticoagulant effect of PP{sub NWF} were significantly improved by γ-ray pre-irradiation-induced graft polymerization of SSS.

  14. TMAP7 simulations of deuterium trapping in pre-irradiated tungsten exposed to high-flux plasma

    NARCIS (Netherlands)

    Wright, G. M.; Mayer, M.; Ertl, K.; de Saint-Aubinc, G.; Rapp, J.

    2011-01-01

    Tungsten targets are irradiated with 12.3 MeV W4+ ions to damage levels up to 2.0 displacements per atom. These irradiated targets are then exposed to high-flux deuterium plasmas with surface temperatures ranging from 360 to 950 K. Nuclear reaction analysis shows significant enhancement of retention

  15. Radiation Hard Silicon Photonics Mach-Zehnder Modulator for HEP applications: all-Synopsys Sentaurus™ Pre-Irradiation Simulation

    CERN Document Server

    Cammarata, Simone

    2017-01-01

    Silicon Photonics may well provide the opportunity for new levels of integration between detectors and their readout electronics. This technology is thus being evaluated at CERN in order to assess its suitability for use in particle physics experiments. In order to check the agreement with measurements and the validity of previous device simulations, a pure Synopsys Sentaurus™ simulation of an un-irradiated Mach-Zehnder silicon modulator has been carried out during the Summer Student project.

  16. Multi-level Control Framework for Enhanced Flexibility of Active Distribution Network

    DEFF Research Database (Denmark)

    Nainar, Karthikeyan; Pokhrel, Basanta Raj; Pillai, Jayakrishnan Radhakrishna

    2017-01-01

    the selected control objectives and provides enhanced flexibility. The control architecture is supported by generation/load forecasting and distribution state estimation techniques to improve the controllability of the network. The multi-level control architecture consists of three levels of hierarchical...

  17. CERN Proton Synchrotron Complex High-Level Controls Renovation

    CERN Document Server

    Deghaye, S; Garcia Quintas, D; Gourber-Pace, M; Kruk, G; Kulikova, O; Lezhebokov, V; Pasinelli, S; Peryt, M; Roderick, C; Roux, E; Sobczak, M; Steerenberg, R; Wozniak, J; Zaharieva, Z

    2009-01-01

    After a detailed study of the Proton Synchrotron (PS) complex requirements by experts of CERN controls & operation groups, a proposal to develop a new system, called Injector Controls Architecture (InCA), was presented to and accepted by the management late 2007. Aiming at the homogenisation of the control systems across CERN accelerators, InCA is based on components developed for the Large Hadron Collider (LHC) but also new components required to fulfil operation needs. In 2008, the project was in its elaboration phase and we successfully validated its architecture and critical use-cases during several machine development sessions. After description of the architecture put in place and the components used, this paper describes the planning approach taken combining iterative development phases with deployment in operation for validation sessions.

  18. Ozone Control Strategies | Ground-level Ozone | New ...

    Science.gov (United States)

    2017-02-16

    The Air Quality Planning Unit's primary goal is to protect your right to breathe clean air. Guided by the Clean Air Act, we work collaboratively with states, communities, and businesses to develop and implement strategies to reduce air pollution from a variety of sources that contribute to the ground-level ozone or smog problem.

  19. design and implementation of a water level controller

    African Journals Online (AJOL)

    2012-03-01

    Mar 1, 2012 ... ... E.C. Anoliefod,a a. National Ctr. For Energy Research and Development, Univ. of Nigeria Nsukka ... Experimental performance results indicated that the device is quite suitable for .... the water level indicator. In the design ...

  20. NAD kinase levels control the NADPH concentration in human cells.

    Science.gov (United States)

    Pollak, Nadine; Niere, Marc; Ziegler, Mathias

    2007-11-16

    NAD kinases (NADKs) are vital, as they generate the cellular NADP pool. As opposed to three compartment-specific isoforms in plants and yeast, only a single NADK has been identified in mammals whose cytoplasmic localization we established by immunocytochemistry. To understand the physiological roles of the human enzyme, we generated and analyzed cell lines stably deficient in or overexpressing NADK. Short hairpin RNA-mediated down-regulation led to similar (about 70%) decrease of both NADK expression, activity, and the NADPH concentration and was accompanied by increased sensitivity toward H(2)O(2). Overexpression of NADK resulted in a 4-5-fold increase in the NADPH, but not NADP(+), concentration, although the recombinant enzyme phosphorylated preferentially NAD(+). Surprisingly, NADK overexpression and the ensuing increase of the NADPH level only moderately enhanced protection against oxidant treatment. Apparently, to maintain the NADPH level for the regeneration of oxidative defense systems human cells depend primarily on NADP-dependent dehydrogenases (which re-reduce NADP(+)), rather than on a net increase of NADP. The stable shifts of the NADPH level in the generated cell lines were also accompanied by alterations in the expression of peroxiredoxin 5 and Nrf2. Because the basal oxygen radical level in the cell lines was only slightly changed, the redox state of NADP may be a major transmitter of oxidative stress.

  1. A Level Converter provided with Slew-Rate Controlling Means

    NARCIS (Netherlands)

    Annema, Anne J.

    2000-01-01

    A level converter for the converting of a first digital signal (U1) having a first voltage range into a second digital signal (U2) having a second voltage range comprising an amplifier (T0) having an input for receiving the first digital signal (U1) and an output for supplying the second digital

  2. Non-destructive Preirradiation Assessment of UN / U-Si “LANL1” ATF formulation

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, Sven C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Losko, Adrian Simon [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pokharel, Reeju [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ickes, Timothy Lee [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hunter, James F. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Donald William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Voit, Stewart Lancaster [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Tremsin, Anton S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bourke, Mark Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); McClellan, Kenneth James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-09-15

    The goal of the Advanced Non-destructive Fuel Examination (ANDE) work package is the development and application of non-destructive neutron imaging and scattering techniques to ceramic and metallic nuclear fuels, ultimately also to irradiated fuels. The results of these characterizations provide complete pre- and post-irradiation on length scales ranging from mm to nm, guide destructive examination, and inform modelling efforts. Besides technique development and application to samples to be irradiated, the ANDE work package also examines possible technologies to provide these characterization techniques pool-side, e.g. at the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) using laser-driven intense pulsed neutron and gamma sources. Neutron tomography and neutron diffraction characterizations were performed on nine pellets; four UN/ U-Si composite formulations (two enrichment levels), three pure U3Si5 reference formulations (two enrichment levels), and two reject pellets with visible flaws (to qualify the technique). The 235U enrichments ranged from 0.2 to 8.8 wt. %. The nitride/silicide composites are candidate compositions for use as Accident Tolerant Fuel (ATF). The monophase U3Si5 material was included as a reference. Pellets from the same fabrication batches will be inserted in the Advanced Test Reactor at Idaho during 2016. We have also proposed a data format to build a database for characterization results of individual pellets. Neutron data reported in this report were collected in the LANSCE run cycle that started in September 2015 and ended in March 2016. This report provides the results for the characterized samples and discussion in the context of ANDE and APIE. We quantified the gamma spectra of several samples in their received state as well as after neutron irradiation to ensure that the neutron irradiation does not add significant activation that would complicate shipment and

  3. HIGH LEVEL MODELLING OF REAL TIME TRAFFIC LIGHT CONTROLLER

    Directory of Open Access Journals (Sweden)

    ADITYA MANDLOI

    2012-12-01

    Full Text Available The objective of this paper is to design and implement traffic control system. The system developed is able to sense the presence of vehicles within certain range by setting the appropriate duration for the traffic signals to react accordingly. By employing logical functions to calculate the appropriate timing for the signals toilluminate, the system can help to solve the problem of traffic congestion. The use of FPGAs (Field Programmable Gate Arrays is an interesting new phenomenon in VLSI development. FPGAs offer all of thefeatures needed to implement most complex designs. Hardware simulation tests were successfully performed on the algorithm implemented into a FPGA (Field Programmable Gate Arrays. The main object of the paper is to design a Real Time Traffic Light Controller (RTTLC using VHDL and implement the RTTLC in XILINX SPARTAN - 3 FPGA.

  4. Low-Cost Options for Moderate Levels of Mercury Control

    Energy Technology Data Exchange (ETDEWEB)

    Sharon Sjostrom

    2008-02-09

    This is the final technical report for a three-site project that is part of an overall program funded by the U.S. Department of Energy's National Energy Technology Laboratory (DOE/NETL) and industry partners to obtain the necessary information to assess the feasibility and costs of controlling mercury from coal-fired utility plants. This report summarizes results from tests conducted at MidAmerican's Louisa Generating Station and Entergy's Independence Steam Electric Station (ISES) and sorbent screening at MidAmerican's Council Bluffs Energy Center (CBEC) (subsequently renamed Walter Scott Energy Center (WSEC)). Detailed results for Independence and Louisa are presented in the respective Topical Reports. As no full-scale testing was conducted at CBEC, screening updates were provided in the quarterly updates to DOE. ADA-ES, Inc., with support from DOE/NETL, EPRI, and other industry partners, has conducted evaluations of EPRI's TOXECON II{trademark} process and of high-temperature reagents and sorbents to determine the capabilities of sorbent/reagent injection, including activated carbon, for mercury control on different coals and air emissions control equipment configurations. An overview of each plant configuration is presented: (1) MidAmerican's Louisa Generating Station burns Powder River Basin (PRB) coal in its 700-MW Unit 1 and employs hot-side electrostatic precipitators (ESPs) with flue gas conditioning for particulate control. This part of the testing program evaluated the effect of reagents used in the existing flue gas conditioning on mercury removal. (2) MidAmerican's Council Bluffs Energy Center typically burns PRB coal in its 88-MW Unit 2. It employs a hot-side ESP for particulate control. Solid sorbents were screened for hot-side injection. (3) Entergy's Independence Steam Electric Station typically burns PRB coal in its 880-MW Unit 2. Various sorbent injection tests were conducted on 1/8 to 1/32 of the flue gas

  5. Control of Quaternary sea-level changes on gas seeps

    Science.gov (United States)

    Riboulot, Vincent; Thomas, Yannick; Berné, Serge; Jouet, Gwénaël.; Cattaneo, Antonio

    2014-07-01

    Gas seeping to the seafloor through structures such as pockmarks may contribute significantly to the enrichment of atmospheric greenhouse gases and global warming. Gas seeps in the Gulf of Lions, Western Mediterranean, are cyclical, and pockmark "life" is governed both by sediment accumulation on the continental margin and Quaternary climate changes. Three-dimensional seismic data, correlated to multi-proxy analysis of a deep borehole, have shown that these pockmarks are associated with oblique chimneys. The prograding chimney geometry demonstrates the syn-sedimentary and long-lasting functioning of the gas seeps. Gas chimneys have reworked chronologically constrained stratigraphic units and have functioned episodically, with maximum activity around sea level lowstands. Therefore, we argue that one of the main driving mechanisms responsible for their formation is the variation in hydrostatic pressure driven by relative sea level changes.

  6. Controlling the levels of airborne pollen: can heterogeneous photocatalysis help?

    Science.gov (United States)

    Sapiña, M; Jimenez-Relinque, E; Castellote, M

    2013-10-15

    Airborne pollen is a worldwide problem because is a very important allergenic agent; it can be altered only by certain microorganisms and by some oxidizers, such as reactive oxygen species (ROS). On the other hand, heterogeneous photocatalysis (HPC) arose as a promising technology for reducing the level of contaminants in the air, based on their degradation by the production of ROS. In this paper, study of the feasibility of HPC to diminish the counts of pollen is undertaken. The research has been carried out at different levels, from solutions to mortar specimens with the evidence that HPC is able to reduce the amount of pollen grains. This is a major breakthrough that opens the door to a whole field of research, already full of gaps, whose implications could be quite controversial.

  7. Low-Cost Options for Moderate Levels of Mercury Control

    Energy Technology Data Exchange (ETDEWEB)

    Sharon Sjostrom

    2006-03-31

    On March 15, 2005, EPA issued the Clean Air Mercury Rule, requiring phased-in reductions of mercury emissions from electric power generators. ADA-ES, Inc., with support from DOE/NETL and industry partners, is conducting evaluations of EPRI's TOXECON II{trademark} process and of high-temperature reagents and sorbents to determine the capabilities of sorbent/reagent injection, including activated carbon, for mercury control on different coals and air emissions control equipment configurations. DOE/NETL targets for total mercury removal are {ge}55% (lignite), {ge}65% (subbituminous), and {ge}80% (bituminous). Based on work done to date at various scales, meeting the removal targets appears feasible. However, work needs to progress to more thoroughly document and test these promising technologies at full scale. This is the final site report for tests conducted at MidAmerican's Louisa Station, one of three sites evaluated in this DOE/NETL program. The other two sites in the program are MidAmerican's Council Bluff Station and Entergy's Independence Station. MidAmerican's Louisa Station burns Powder River Basin (PRB) coal and employs hot-side electrostatic precipitators with flue gas conditioning for particulate control. This part of the testing program evaluated the effect of reagents used in the existing flue gas conditioning on mercury removal.

  8. One step graft copolymerization of acrylic acid and sodium styrene sulfonate onto high-density polyethylene film by preirradiation method

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    High-density polyethylene (HDPE) films were irradiated by 60Co gamma ray with a dose of 100 kGy in air and then immersed in aqueous solution of acrylic acid (AA) and sodium styrene sulfonate (SSS) at different temperature. The effects of grafting conditions such as temperature, reaction time, Mohr's salt concentration, and total concentration of monomer on grafting yield were studied. Both grafting yield of AA and SSS onto HDPE respectively increases with total concentration of monomers. The highest grafting yield was observed at 3 mol/L monomers where the grafted PE swelled to the largest extent in the monomers mixture. The grafting yield increases with reaction time and then levels off. At higher temperature, the grafting yield decreases with Mohr's salt concentration, but increases at low temperature when Mohr's salt concentration is 0.083%. Which can be interpreted that in the presence of Fe2+ diperoxides and hydroperoxides may decompose at low temperature to form radical which can initiate the grafting. The physical and chemical properties of grafting films were also investigated.

  9. Control Loops for the J-PARC RCS Digital Low-Level RF Control

    CERN Document Server

    Schnase, Alexander; Ezura, Eizi; Hara, Keigo; Nomura, Masahiro; Ohmori, Chihiro; Takagi, Akira; Tamura, Fumihiko; Yamamoto, Masanobu; Yoshii, Masahito

    2005-01-01

    The low-level radiofrequency control for the Rapic Cycling Synchrotron of J-PARC is based on digital signal processing. This system controls the acceleration voltages of 12 magnetic alloy loaded cavities. To achive a short overall delay, mandatory for stable loop operation, the data-processing is based on distributed arithmetics in FPGA. Due to the broadband characteristic of the acceleration cavities, no tuning loop is needed. To handle the large beam current, the RF system operates simultaneously with dual harmonics (h=2) and (h=4). The stability of the amplitude loops is limited by the delay of the FIR filters used after downconversion. The phase loop offers several operation modes to define the phase relation of (h=2) and (h=4) between the longitudinal beam signal and the vector-sum of the cavity voltages. Besides the FIR filters, we provide cascaded CIC filters with smoothly varying coefficients. Such a filter tracks the revolution frequency and has a substantially shorter delay, thereby increasing the s...

  10. Options for water-level control in developed wetlands

    Science.gov (United States)

    Kelley, J. R.; Laubhan, M. K.; Reid, F. A.; Wortham, J. S.; Fredrickson, L. H.

    1993-01-01

    Wetland habitats in the United States currently are lost at a rate of 260,000 acres/year (105,218 ha/year). Consequently, water birds concentrate in fewer and smaller areas. Such concentrations may deplete food supplies and influence behavior, physiology, and survival. Continued losses increase the importance of sound management of the remaining wetlands because water birds depend on them. Human activities modified the natural hydrology of most remaining wetlands in the conterminous United States, and such hydrologic alterations frequently reduce wetland productivity. The restoration of original wetland functions and productivity often requires the development of water distribution and discharge systems to emulate natural hydrologic regimes. Construction of levees and correct placement of control structures and water-delivery and water-discharge systems are necessary to (1) create soil and water conditions for the germination of desirable plants, (2) control nuisance vegetation, (3) promote the production of invertebrates, and (4) make foods available for wildlife that depends of wetlands (Leaflets 13.2.1 and 13.4.6). This paper provides basic guidelines for the design of wetlands that benefit wildlife. If biological considerations are not incorporated into such designs, the capability of managing wetlands for water birds is reduced and costs often are greater. Although we address the development of palustrine wetlands in migration and wintering areas, many of the discussed principles are applicable to the development of other wetland types and in other locations.

  11. Using Lighting Levels to Control Sound Levels in a College Library.

    Science.gov (United States)

    Hronek, Beth

    1997-01-01

    Many libraries have noise problems that can't be fixed with ceiling and carpet treatments, physical arrangement, or sound barriers. This study at Henderson Community College (Henderson KY) attempted to confirm results from an earlier study suggesting that reducing light levels led to reduced noise. The data showed mixed results, but overall the…

  12. From street level to system level bureaucracies. How ICT is transforming administrative discretion and constitutional control

    NARCIS (Netherlands)

    Bovens, M.A.P.; Zouridis, S.

    2002-01-01

    The use of ICT is rapidly changing the structure of a number of large executive public agencies. They used to be machine bureaucracies in which street level officials exercised ample administrative discretion in dealing with individual clients. This was kept in check by elaborate systems of external

  13. Cosmogenic He and Ne in chondrules from clastic matrix and a lithic clast of Murchison: No pre-irradiation by the early sun

    Science.gov (United States)

    Riebe, My E. I.; Huber, Liliane; Metzler, Knut; Busemann, Henner; Luginbuehl, Stefanie M.; Meier, Matthias M. M.; Maden, Colin; Wieler, Rainer

    2017-09-01

    other regolithic meteorites for which large occasional excesses of cosmogenic noble gases have been reported. Considering pre-irradiation in a regolith (2π exposure), the pre-exposure times for these four chondrules are at least between some 4 and 40 Ma near the very surface of the parent body, and even longer if they were buried deeper in the regolith.

  14. Sulfate threshold target to control methylmercury levels in wetland ecosystems

    Science.gov (United States)

    Corrales, J.; Naja, G.M.; Dziuba, C.; Rivero, R.G.; Orem, W.

    2011-01-01

    Sulfate contamination has a significant environmental implication through the stimulation of toxic hydrogen sulfide and methylmercury (MeHg) production. High levels of MeHg are a serious problem in many wetland ecosystems worldwide. In the Florida Everglades, it has been demonstrated that increasing MeHg occurrence is due to a sulfate contamination problem. A promising strategy of lowering the MeHg occurrence is to reduce the amount of sulfate entering the ecosystem. High surface water sulfate concentrations in the Everglades are mainly due to discharges from the Everglades Agricultural Area (EAA) canals. Water and total sulfur mass balances indicated that total sulfur released by soil oxidation, Lake Okeechobee and agricultural application were the major sources contributing 49,169, 35,217 and 11,775mtonsyear-1, respectively. Total sulfur loads from groundwater, levees, and atmospheric deposition contributed to a lesser extent: 4055; 5858 and 4229mtonsyear-1, respectively. Total sulfur leaving the EAA into Water Conservation Areas (WCAs) through canal discharge was estimated at 116,360mtonsyear-1, and total sulfur removed by sugarcane harvest accounted for 23,182mtonsyear-1. Furthermore, a rise in the mineral content and pH of the EAA soil over time, suggested that the current rates of sulfur application would increase as the buffer capacity of the soil increases. Therefore, a site specific numeric criterion for sulfate of 1mgL-1 was recommended for the protection of the Everglades; above this level, mercury methylation is enhanced. In parallel, sulfide concentrations in the EAA exceeded the 2??gL-1 criterion for surface water already established by the U.S. Environmental Protection Agency (EPA). ?? 2011 Elsevier B.V.

  15. Snail levels control the migration mechanism of mesenchymal tumor cells.

    Science.gov (United States)

    Belgiovine, Cristina; Chiesa, Giulio; Chiodi, Ilaria; Frapolli, Roberta; Bonezzi, Katiuscia; Taraboletti, Giulia; D'Incalci, Maurizio; Mondello, Chiara

    2016-07-01

    Cancer cells use two major types of movement: Mesenchymal, which is typical of cells of mesenchymal origin and depends on matrix metalloproteinase (MMP) activity, and amoeboid, which is characteristic of cells with a rounded shape and relies on the activity of Rho-associated kinase (ROCK). The present authors previously demonstrated that, during neoplastic transformation, telomerase-immortalized human fibroblasts (cen3tel cells) acquired a ROCK-dependent/MMP independent mechanism of invasion, mediated by the downregulation of the ROCK cellular inhibitor Round (Rnd)3/RhoE. In the present study, cen3tel transformation was also demonstrated to be paralleled by downregulation of Snail, a major determinant of the mesenchymal movement. To test whether Snail levels could determine the type of movement adopted by mesenchymal tumor cells, Snail was ectopically expressed in tumorigenic cells. It was observed that ectopic Snail did not increase the levels of typical mesenchymal markers, but induced cells to adopt an MMP-dependent mechanism of invasion. In cells expressing ectopic Snail, invasion became sensitive to the MMP inhibitor Ro 28-2653 and insensitive to the ROCK inhibitor Y27632, suggesting that, once induced by Snail, the mesenchymal movement prevails over the amoeboid one. Snail-expressing cells had a more aggressive behavior in vivo, and exhibited increased tumor growth rate and metastatic ability. These results confirm the high plasticity of cancer cells, which can adopt different types of movement in response to changes in the expression of specific genes. Furthermore, the present findings indicate that Rnd3 and Snail are possible regulators of the type of invasion mechanism adopted by mesenchymal tumor cells.

  16. Sulfate threshold target to control methylmercury levels in wetland ecosystems.

    Science.gov (United States)

    Corrales, Juliana; Naja, Ghinwa M; Dziuba, Catherine; Rivero, Rosanna G; Orem, William

    2011-05-01

    Sulfate contamination has a significant environmental implication through the stimulation of toxic hydrogen sulfide and methylmercury (MeHg) production. High levels of MeHg are a serious problem in many wetland ecosystems worldwide. In the Florida Everglades, it has been demonstrated that increasing MeHg occurrence is due to a sulfate contamination problem. A promising strategy of lowering the MeHg occurrence is to reduce the amount of sulfate entering the ecosystem. High surface water sulfate concentrations in the Everglades are mainly due to discharges from the Everglades Agricultural Area (EAA) canals. Water and total sulfur mass balances indicated that total sulfur released by soil oxidation, Lake Okeechobee and agricultural application were the major sources contributing 49,169, 35,217 and 11,775mtonsyear(-1), respectively. Total sulfur loads from groundwater, levees, and atmospheric deposition contributed to a lesser extent: 4055; 5858 and 4229mtonsyear(-1), respectively. Total sulfur leaving the EAA into Water Conservation Areas (WCAs) through canal discharge was estimated at 116,360mtonsyear(-1), and total sulfur removed by sugarcane harvest accounted for 23,182mtonsyear(-1). Furthermore, a rise in the mineral content and pH of the EAA soil over time, suggested that the current rates of sulfur application would increase as the buffer capacity of the soil increases. Therefore, a site specific numeric criterion for sulfate of 1mgL(-1) was recommended for the protection of the Everglades; above this level, mercury methylation is enhanced. In parallel, sulfide concentrations in the EAA exceeded the 2μgL(-1) criterion for surface water already established by the U.S. Environmental Protection Agency (EPA).

  17. Design and Implementation of a Water Level Controller using Fuzzy Logic

    Directory of Open Access Journals (Sweden)

    Namrata Dey

    2013-06-01

    Full Text Available This paper analyzes the effectiveness of water level control using fuzzy logic. The water level in the tank is sensed using transistor switching principle. The level sensed is fed to the PIC16 microcontroller. The user provides the set point to the microcontroller through serial communication using the COM development port software, Terminal. It computes the error as the difference between the set point and the process variable. The fuzzy logic programmed in the microcontroller is applied which controls the water level in the tank using the drain and the feed pumps. Once the set point has been reached, the message along with the present level is sent back through serial communication to the user interface on a PC. Thus, the water level in the tank is controlled according to the set point given by the user. The implementation of a fuzzy level controller has many applications such as boiler drum level control, reverse osmosis plant, demineralisation plant etc.

  18. Improvement of Control Infrastructure and High Level Application for KOMAC LINAC

    Energy Technology Data Exchange (ETDEWEB)

    Song, Young-Gi; Kim, Jae-Ha; Ahn, Tae-Sung; Kwon, Hyeok-Jung; Cho, Yong-Sub [Korea Atomic Energy Research Institute, Gyeongju (Korea, Republic of)

    2015-10-15

    The Korea multi-purpose accelerator complex (KOMAC) has two beam extraction points at 20 and 100 MeV for proton beam utilization. There are about 70 control systems for controlling the KOMAC subsystems, such as the ion source, the radio frequency, the diagnostic devices, the magnet power supply, and the cooling system. The infrastructure which includes network system, local controllers, and control system environment was required to be changed to process increasing process variables without fail. Experimental Physics and Industrial Control System (EPICS) based high level control environment which includes alarm, data archiving was changed to support the improved infrastructure of KOMAC control system. In this paper, we will describe the improvement of infrastructures for the KOMAC control system and EPICS based high level application. We improved the control network environment and EPCIS based high level application for enhancement of the KOMAC control system.

  19. Genetically Generated Double-Level Fuzzy Controller with a Fuzzy Adjustment Strategy

    DEFF Research Database (Denmark)

    Achiche, Sofiane; Wang, Wei; Fan, Zhun;

    2007-01-01

    This paper describes the use of a genetic algorithm (GA) in tuning a double-level modular fuzzy logic controller (DLMFLC), which can expand its control working zone to a larger spectrum than a single-level FLC. The first-level FLCs are tuned by a GA so that the input parameters of their membership...... functions and fuzzy rules are optimized according to their individual working zones. The second-level FLC is then used to adjust contributions of the first-level FLCs to the final output signal of the whole controller, i.e., DLMFLC, so that it can function in a wider spectrum covering all individual working...

  20. Quantitative feedback theory and zero phase error tracking control combined robust control for radar truck leveling simulator

    Institute of Scientific and Technical Information of China (English)

    LING; Xuan; LI; Xiao-hui; ZHU; Yu-quan; FENG; Tian-lin

    2009-01-01

    Radar leveling system is the key equipment for improving the radar mobility and survival capability. A combined quantitative feedback theory(QFT)controller is designed for the radar truck leveling simulator in this paper, which suffers from strong nonlinearities and system parameter uncertainties. QFT can reduce the plant uncertainties and stabilize the system, but it fails to obtain high-precision tracking. This drawback can be solved by a robust QFT control scheme based on zero phase error tracking control(ZPETC)compensation. The combined controller not only possesses high robustness, but greatly improves the system performance. To verify the effectiveness and the potential of the proposed controller, a series of experiments have been carried out. Experimental results have demonstrated its robustness against a large range of parameters variation and high tracking precision performance, as well as its capability of restraining the load coupling among channels. The combined QFT controller can drive the radar truck leveling platform accurately, quickly and stably.

  1. Control System Design of a DSP-based Real-time Leveling Platform

    Directory of Open Access Journals (Sweden)

    Zhang Jin Ming

    2016-01-01

    Full Text Available Since platform working in the sea is badly influenced by the wave, leveling control system is researched to control the leveling platform, so as to prevent the device which is fixed on the platform from being affected. TMS320F2812 chip is set as the control core, and serial communication module, gyroscope etc. are adopted to design real-time leveling control system. Gyroscopes are used to measure the angular speed of the carrier and the angle of the platform, filtering processing is done to the data collected by the gyroscopes and PID algorithm is adopted to calculate the real-time speed of motor ,in order to control the leveling platform. Tests are conducted to prove that the system can well control the leveling platform, in which the shake range of the platform is (-12°, +12°, while the shake range of carrier is only about (-0.5° +0.5 °.

  2. Undetectable inhibin B serum levels in men after testicular irradiation

    DEFF Research Database (Denmark)

    Petersen, P M; Andersson, A M; Rørth, M

    1999-01-01

    A group of men treated with testicular irradiation for carcinoma in situ in the remaining testis after orchidectomy for unilateral testicular germ cell cancer was used as a model to study of the effect of selective eradication of germ cells on the levels of serum inhibin B in the human male....... Thirteen men with verified spermatogenesis and detectable preirradiation levels of serum inhibin B (median, 55; range, 23-193 pg/mL) were investigated before and after testicular irradiation (14-20 Gy). All patients had undetectable levels of inhibin B 2-12 months (median, 5 months) after radiotherapy (...

  3. Object-based task-level control: A hierarchical control architecture for remote operation of space robots

    Science.gov (United States)

    Stevens, H. D.; Miles, E. S.; Rock, S. J.; Cannon, R. H.

    1994-01-01

    Expanding man's presence in space requires capable, dexterous robots capable of being controlled from the Earth. Traditional 'hand-in-glove' control paradigms require the human operator to directly control virtually every aspect of the robot's operation. While the human provides excellent judgment and perception, human interaction is limited by low bandwidth, delayed communications. These delays make 'hand-in-glove' operation from Earth impractical. In order to alleviate many of the problems inherent to remote operation, Stanford University's Aerospace Robotics Laboratory (ARL) has developed the Object-Based Task-Level Control architecture. Object-Based Task-Level Control (OBTLC) removes the burden of teleoperation from the human operator and enables execution of tasks not possible with current techniques. OBTLC is a hierarchical approach to control where the human operator is able to specify high-level, object-related tasks through an intuitive graphical user interface. Infrequent task-level command replace constant joystick operations, eliminating communications bandwidth and time delay problems. The details of robot control and task execution are handled entirely by the robot and computer control system. The ARL has implemented the OBTLC architecture on a set of Free-Flying Space Robots. The capability of the OBTLC architecture has been demonstrated by controlling the ARL Free-Flying Space Robots from NASA Ames Research Center.

  4. Improvement of Direct Torque Control by using a Space Vector Modulation Control of Three-Level Inverter

    Science.gov (United States)

    Achalhi, A.; Bezza, M.; Belbounaguia, N.; Boujoudi, B.

    2017-03-01

    The performances of Direct Torque Control (DTC) of Induction machine are highly related to the inverter used therewith. The purpose of this paper is to highlight the efficiency of the space vector modulation (SVM) control of three level inverter associated with the direct torque control. The first part of this work is devoted to present the mathematical models of the DTC associated with 2-levels inverter then 3-levels inverter. Simulations on Matlab/Simulink will allow a comparative study to highlight advantages of the use of three levels inverter. The second part is devoted to the improvement of the DTC associated with a 3-levels inverter by application of the space vector modulation strategy (SVM) in order to manage the switching frequency and reduce harmonics. The efficiency of this solution will be attested by simulation on Matlab/Simulink.

  5. Depth Level Control System using Peripheral Interface Controller for Underwater Vehicle

    Directory of Open Access Journals (Sweden)

    Muhamad Fadli Ghani

    2013-01-01

    Full Text Available This research explained on a design and development of an Automatic Depth Control System for underwater vehicle. Definition of underwater vehicle is a robotic sub-sea that is a part of the emerging field of autonomous and unmanned vehicles. This project shows the implementation’s development of an Automatic Depth Control System on a test prototyping vehicle especially involved small-scale and low cost sub-sea robots. The Automatic Depth Control System assembled with mechanical system and module of electronic system for development of a controller.

  6. ENERGY EFFICIENT FLOW AND LEVEL CONTROL IN A HYDRO POWER PLANT USING FUZZY LOGIC

    Directory of Open Access Journals (Sweden)

    A. Selwin Mich Priyadharson

    2014-01-01

    Full Text Available The main objective and an innovative design of this work is to improve the energy efficiency by controlling the variables flow and level in a hydroelectric power plant using Programmable Logic Control (PLC-Human Machine Interface (HMI and fuzzy logic approach. This project will focus on design and development of flow and level controller for small scale hydro generating units by implementing gate control based on PLC-HMI and Fuzzy Logic Control (FLC. So far there is no other better performing control scheme, with uncomplicated approach, in order to match and satisfy the dynamic changes in load demand. In this project, FLC will be applied to flow and level control for small scale hydro generating units is proposed. A lab scale experimental setup is made-up as prototype model for flow and level control and simulation outputs were achieved, using PLC-HMI based fuzzy controller scheme. The hardware set up is designed with 5 stages in the tank 1 and 2 stages in the tank 2. Based on the outputs of the level sensors from tanks 1 and 2, the ladder logic will perform. B&R Industrial Automation PLC inbuilt with 24 digital inputs and provides 16 potential free outputs is used to perform control action. Finally, the performance of the proposed scheme is evaluated by simulation results by comparing with conventional controllers output using the data collected from the hydroelectric power plant. The merits of the proposed Fuzzy scheme over the conventional method are spotlighted.

  7. Comparison of serum BDNF levels in deficit and nondeficit chronic schizophrenia and healthy controls.

    Science.gov (United States)

    Valiente-Gómez, Alicia; Amann, Benedikt L; Mármol, Frederic; Oliveira, Cristina; Messeguer, Ana; Lafuente, Amalia; Pomarol-Clotet, Edith; Bernardo Arroyo, Miguel

    2014-12-15

    The aim of this study was to compare serum BDNF levels of chronic schizophrenic patients, with or without deficit syndrome, and healthy controls. A comparative study of serum BDNF levels, determined by ELISA, was performed in 47 chronic patients with schizophrenia matched with 47 healthy controls. A part of the chronic schizophrenic sample was further divided into patients with a deficit (n=14) and a nondeficit syndrome (n=20), according to the Proxy for the Deficit Syndrome Scale. A significant difference was observed in decreased serum BDNF levels between chronic schizophrenia and healthy controls. No statistical significant differences in BDNF levels between deficit and nondeficit chronic schizophrenic patients were found. Our study confirms differences of serum BDNF levels of chronic schizophrenia and healthy controls, which correspond to the clinical progression of the disease. Our results do not support a relation between deficit profile in chronic schizophrenia and lower serum BDNF levels.

  8. Higher Levels of Psychopathy Predict Poorer Motor Control: Implications for Understanding the Psychopathy Construct

    OpenAIRE

    Robinson, Michael D.; Bresin, Konrad

    2014-01-01

    A review of the literature suggests that higher levels of psychopathy may be linked to less effective behavioral control. However, several commentators have urged caution in making statements of this type in the absence of direct evidence. In two studies (total N = 142), moment-to-moment accuracy in a motor control task was examined as a function of dimensional variations in psychopathy in an undergraduate population. As hypothesized, motor control was distinctively worse at higher levels of ...

  9. Steam drum level control studies of a natural circulation multi loop reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Rajesh; Contractor, A.D.; Srivastava, Abhishek; Lele, H.G. [Bhabha Atomic Research Centre, Trombay, Mumbai (India). Reactor Safety Div.; Vaze, K.K. [Bhabha Atomic Research Centre, Trombay, Mumbai (India). Reactor Design and Development Group

    2013-12-15

    The proposed heavy water moderated and light water cooled pressure tube type boiling water reactor works on natural circulation at all power levels. It has parallel inter-connected loops with 452 boiling channels in the main heat transport system configuration. These multiple (four) interconnected loops influence the steam drum level control adversely through the common reactor inlet header. Alternate design studies made earlier for efficient control of SD levels have shown favorable results. This has lead to explore further the present scheme with the compartmentalization of CRIH into four compartments catering to four loops separately. The conventional 3-element level control has been found to be working satisfactorily. The interconnections between ECCS header and inlet header compartments have also increased the safety margin for various LOCA and design basis events. The paper deals with the SD level control aspects for this novel MHT configuration which has been analyzed for various PIEs (Postulated Initiating Events) and found to be satisfactory. (orig.)

  10. Chemical control over the energy-level alignment in a two-terminal junction

    Science.gov (United States)

    Yuan, Li; Franco, Carlos; Crivillers, Núria; Mas-Torrent, Marta; Cao, Liang; Sangeeth, C. S. Suchand; Rovira, Concepció; Veciana, Jaume; Nijhuis, Christian A.

    2016-07-01

    The energy-level alignment of molecular transistors can be controlled by external gating to move molecular orbitals with respect to the Fermi levels of the source and drain electrodes. Two-terminal molecular tunnelling junctions, however, lack a gate electrode and suffer from Fermi-level pinning, making it difficult to control the energy-level alignment of the system. Here we report an enhancement of 2 orders of magnitude of the tunnelling current in a two-terminal junction via chemical molecular orbital control, changing chemically the molecular component between a stable radical and its non-radical form without altering the supramolecular structure of the junction. Our findings demonstrate that the energy-level alignment in self-assembled monolayer-based junctions can be regulated by purely chemical modifications, which seems an attractive alternative to control the electrical properties of two-terminal junctions.

  11. A Simple Strategy of Controlling a Balanced Voltage Capacitor in Single Phase Five-Level Inverter

    Directory of Open Access Journals (Sweden)

    Leonardus Heru Pratomo

    2015-03-01

    Full Text Available The five-level inverter has been used for many applications in renewable energy systems. Even though its harmonic distortion was lower than the conventional two-level inverter. The five-level converter has some disadvantages such as increasing power semiconductor, complex pulse width modulation control methods, and problem with the voltage balancing of the capacitor. This paper aims to propose a modified five-level inverter based on sinusoidal pulse width modulation using phase shifted carrier to enhancing the capacitor voltage balancing. This modified five-level inverter reduces the overall cost and the complexity of the pulse width modulator. Thus making the proposed control system highly simple. The performance and its controller were validated by means of standard laboratory equipments. The analysis, simulation and implementation result showed better performance of five-level inverter.

  12. A Robust Control Scheme for Medium-Voltage-Level DVR Implementation

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Loh, Poh Chiang; Li, Yun Wei;

    2007-01-01

    In this paper, a robust control scheme with an outer Hinfin voltage control loop and an inner current control loop is designed and implemented on a medium-voltage (MV)-level dynamic voltage restorer (DVR) system. Through a simple selection of weighting functions, the synthesized Hinfin controller....../nonlinear load and induction motor load) conditions. It is shown that the proposed control scheme is effective in both balanced and unbalanced sag compensation and load disturbance rejection, as its robustness is explicitly specified....... of Hinfin controller weighting function selection, inner current loop tuning, and system disturbance rejection capability is presented. Finally, the designed control scheme is extensively tested on a laboratory 10-kV MV-level DVR system with varying voltage sag (balanced and unbalanced) and loading (linear...

  13. Development of a Robust Model-Based Water Level Controller for U-Tube Steam Generator

    Energy Technology Data Exchange (ETDEWEB)

    Basher, A.M.H.

    2001-09-04

    Poor control of steam generator water level of a nuclear power plant may lead to frequent nuclear reactor shutdowns. These shutdowns are more common at low power where the plant exhibits strong non-minimum phase characteristics and flow measurements at low power are unreliable in many instances. There is need to investigate this problem and systematically design a controller for water level regulation. This work is concerned with the study and the design of a suitable controller for a U-Tube Steam Generator (UTSG) of a Pressurized Water Reactor (PWR) which has time varying dynamics. The controller should be suitable for the water level control of UTSG without manual operation from start-up to full load transient condition. Some preliminary simulation results are presented that demonstrate the effectiveness of the proposed controller. The development of the complete control algorithm includes components such as robust output tracking, and adaptively estimating both the system parameters and state variables simultaneously. At the present time all these components are not completed due to time constraints. A robust tracking component of the controller for water level control is developed and its effectiveness on the parameter variations is demonstrated in this study. The results appear encouraging and they are only preliminary. Additional work is warranted to resolve other issues such as robust adaptive estimation.

  14. Open-Loop Control in Quantum Optics: Two-Level Atom in Modulated Optical Field

    CERN Document Server

    Saifullah, Sergei

    2008-01-01

    The methods of mathematical control theory are widely used in the modern physics, but still they are less popular in quantum science. We will discuss the aspects of control theory, which are the most useful in applications to the real problems of quantum optics. We apply this technique to control the behavior of the two-level quantum particles (atoms) in the modulated external optical field in the frame of the so called "semi classical model", where quantum two-level atomic system (all other levels are neglected) interacts with classical electromagnetic field. In this paper we propose a simple model of feedforward (open-loop) control for the quantum particle system, which is a basement for further investigation of two-level quantum particle in the external one-dimensional optical field.

  15. Construing Morality at High versus Low Levels Induces Better Self-control, Leading to Moral Acts

    Directory of Open Access Journals (Sweden)

    Chia-Chun Wu

    2017-06-01

    Full Text Available Human morality entails a typical self-control dilemma in which one must conform to moral rules or socially desirable norms while exerting control over amoral, selfish impulses. Extant research regarding the connection between self-control and level of construal suggest that, compared with a low-level, concrete construal (highlighting means and resources, e.g., answering ‘how’ questions, a high-level, abstract construal (highlighting central goals, e.g., answering ‘why’ questions promotes self-control. Hence, construing morality at higher levels rather than lower levels should engender greater self-control and, it follows, promote a tendency to perform moral acts. We conducted two experiments to show that answering “why” (high-level construal vs. “how” (low-level construal questions regarding morality was associated with a situational state of greater self-control, as indexed by less Stroop interference in the Stroop color-naming task (Experiments 1 and 2. Participants exposed to “why” questions regarding morality displayed a greater inclination for volunteerism (Experiment 1, showed a lower tendency toward selfishness in a dictator game (Experiment 2, and were more likely to return undeserved money (Experiment 2 compared with participants exposed to “how” questions regarding morality. In both experiments, self-control mediated the effect of a high-level construal of morality on dependent measures. The current research constitutes a new approach to promoting prosociality and moral education. Reminding people to think abstractly about human morality may help them to generate better control over the temptation to benefit from unethical acts and make it more likely that they will act morally.

  16. Complete controllability of finite quantum systems with twofold energy level degeneracy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Zhedong; Fu, H C, E-mail: hcfu@szu.edu.c [School of Physical Sciences and Technology, Shenzhen University, Shenzhen 518060 (China)

    2010-05-28

    Complete controllability of finite-dimensional quantum systems with energy level degeneracy is investigated using two different approaches. One approach is to apply a weak constant field to eliminate the degeneracy and then control it using techniques developed for non-degenerate quantum systems. Conditions for the elimination of degeneracy are found and the issues of influence of relaxation time of a constant external field on the target state are addressed through the fidelity. Another approach is to control the degenerate system by a single control field directly. It is found that the system with twofold degenerate excited states and non-degenerate ground state is completely controllable except for the two-level system. Conditions of complete controllability are found for both systems with different energy gaps and with equal energy gaps.

  17. Simplifying Physical Realization of Gaussian Particle Filters with Block-Level Pipeline Control

    Directory of Open Access Journals (Sweden)

    Miodrag Bolić

    2005-03-01

    Full Text Available We present an efficient physical realization method of particle filters for real-time tracking applications. The methodology is based on block-level pipelining where data transfer between processing blocks is effectively controlled by autonomous distributed controllers. Block-level pipelining maintains inherent operational concurrency within the algorithm for high-throughput execution. The proposed use of controllers, via parameters reconfiguration, greatly simplifies the overall controller structure, and alleviates potential speed bottlenecks that may arise due to complexity of the controller. A Gaussian particle filter for bearings-only tracking problem is realized based on the presented methodology. For demonstration, individual coarse grain processing blocks comprising particle filters are synthesized using commercial FPGA. From the execution characteristics obtained from the implementation, the overall controller structure is derived according to the methodology and its temporal correctness verified using Verilog and SystemC.

  18. On Usage of Pareto curves to Select Wind Turbine Controller Tunings to the Wind Turbulence Level

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh

    2015-01-01

    to update an model predictive wind turbine controller tuning as the wind turbulence increases, as increased turbulence levels results in higher loads for the same controller tuning. In this paper the Pareto curves are computed using an industrial high fidelity aero-elastic model. Simulations show...

  19. Identification and robust water level control of horizontal steam generators using quantitative feedback theory

    Energy Technology Data Exchange (ETDEWEB)

    Safarzadeh, O., E-mail: O_Safarzadeh@sbu.ac.ir [Shahid Beheshti University, P.O. Box: 19839-63113, Tehran (Iran, Islamic Republic of); Khaki-Sedigh, A. [K. N. Toosi University of Technology, Tehran (Iran, Islamic Republic of); Shirani, A.S. [Shahid Beheshti University, P.O. Box: 19839-63113, Tehran (Iran, Islamic Republic of)

    2011-09-15

    Highlights: {yields} A robust water level controller for steam generators (SGs) is designed based on the Quantitative Feedback Theory. {yields} To design the controller, fairly accurate linear models are identified for the SG. {yields} The designed controller is verified using a developed novel global locally linear neuro-fuzzy model of the SG. {yields} Both of the linear and nonlinear models are based on the SG mathematical thermal-hydraulic model developed using the simulation computer code. {yields} The proposed method is easy to apply and guarantees desired closed loop performance. - Abstract: In this paper, a robust water level control system for the horizontal steam generator (SG) using the quantitative feedback theory (QFT) method is presented. To design a robust QFT controller for the nonlinear uncertain SG, control oriented linear models are identified. Then, the nonlinear system is modeled as an uncertain linear time invariant (LTI) system. The robust designed controller is applied to the nonlinear plant model. This nonlinear model is based on a locally linear neuro-fuzzy (LLNF) model. This model is trained using the locally linear model tree (LOLIMOT) algorithm. Finally, simulation results are employed to show the effectiveness of the designed QFT level controller. It is shown that it will ensure the entire designer's water level closed loop specifications.

  20. Low-level Control of Network Elements from an Agent Platform

    DEFF Research Database (Denmark)

    Hansen, Mads Stenhuus; Jensen, P.; Soldatos, J.;

    1999-01-01

    An important issue for the implementation of an agent system, which controls a telecommunications network, is to enable low-level access of the network devices by the agent platform, bypassing the control logic inherent in them. This issue has been coped with successfully in the IMPACT project...

  1. Time-minimal control of dissipative two-level quantum systems: The Integrable case

    CERN Document Server

    Bonnard, B

    2008-01-01

    The objective of this article is to apply recent developments in geometric optimal control to analyze the time minimum control problem of dissipative two-level quantum systems whose dynamics is governed by the Lindblad equation. We focus our analysis on the case where the extremal Hamiltonian is integrable.

  2. Programmable Logic Controllers for Systems of Automatic of the Level Crossing

    Directory of Open Access Journals (Sweden)

    Mieczyslaw Kornaszewski

    2006-01-01

    Full Text Available The railway crossings are vulnerable to incidence of high number of accidents often deadly. In order to face this problem, the modern systems of automatic of the level crossing have been introduced. These systems are based on Programmable Logic Controllers, which allow the designers to exploit self-control mechanisms, events acquiring, technical diagnostic which in turn enable remote control and acquisition of faults.

  3. Training elements at different levels in the strategies for control of schistosomiasis

    DEFF Research Database (Denmark)

    Ørnbjerg, Niels; Simonsen, P. E.; Furu, Peter

    1989-01-01

    Recently acquired comprehensive knowledge concerning the epidemiology of schistosomiasis has provided the background for the establishment of schistosomiasis control strategies. However, the planning, implementation, and maintenance of such control programmes requires sufficient numbers of well t...... trained personnel at the local, district and central levels. Training of health personnel as well as motivation of the community are fundamental and essential elements in any schistosomiasis control programme. The training elements and approaches are discussed....

  4. Engine control strategy for a series hybrid electric vehicle incorporating load-leveling and computer controlled energy management

    Energy Technology Data Exchange (ETDEWEB)

    Hochgraf, C.G.; Ryan, M.J.; Wiegman, H.L. [Univ. of Wisconsin, Madison, WI (United States)

    1996-09-01

    This paper identifies important engine, alternator and battery characteristics needed for determining an appropriate engine control strategy for a series hybrid electric vehicle. Examination of these characteristics indicates that a load-leveling strategy applied to the small engine will provide better fuel economy than a power-tracking scheme. An automatic energy management strategy is devised whereby a computer controller determines the engine-alternator turn-on and turn-off conditions and controls the engine-alternator autonomously. Battery state of charge is determined from battery voltage and current measurements. Experimental results of the system`s performance in a test vehicle during city driving are presented.

  5. Nonlinear Power-Level Control of the MHTGR Only with the Feedback Loop of Helium Temperature

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2013-02-01

    Full Text Available Power-level control is a crucial technique for the safe, stable and efficient operation of modular high temperature gas-cooled nuclear reactors (MHTGRs, which have strong inherent safety features and high outlet temperatures. The current power-level controllers of the MHTGRs need measurements of both the nuclear power and the helium temperature, which cannot provide satisfactory control performance and can even induce large oscillations when the neutron sensors are in error. In order to improve the fault tolerance of the control system, it is important to develop a power-level control strategy that only requires the helium temperature. The basis for developing this kind of control law is to give a state-observer of the MHTGR a relationship that only needs the measurement of helium temperature. With this in mind, a novel nonlinear state observer which only needs the measurement of helium temperature is proposed. This observer is globally convergent if there is no disturbance, and has the L2 disturbance attenuation performance if the disturbance is nonzero. The separation principle of this observer is also proven, which denotes that this observer can recover the performance of both globally asymptotic stabilizers and L2 disturbance attenuators. Then, a new dynamic output feedback power-level control strategy is established, which is composed of this observer and the well-built static state-feedback power-level control based upon iterative dissipation assignment (IDA-PLC. Finally, numerical simulation results show the high performance and feasibility of this newly-built dynamic output feedback power-level controller.

  6. Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials?

    OpenAIRE

    Sierevelt Inger N; Krips Rover; Struijs Peter AA; Poolman Rudolf W; Lutz Kristina H; Bhandari Mohit

    2006-01-01

    Abstract Background The Levels of Evidence Rating System is widely believed to categorize studies by quality, with Level I studies representing the highest quality evidence. We aimed to determine the reporting quality of Randomised Controlled Trials (RCTs) published in the most frequently cited general orthopaedic journals. Methods Two assessors identified orthopaedic journals that reported a level of evidence rating in their abstracts from January 2003 to December 2004 by searching the instr...

  7. Energy Conservation Analysis and Control of Hybrid Active Semiactive Suspension with Three Regulating Damping Levels

    Directory of Open Access Journals (Sweden)

    Long Chen

    2016-01-01

    Full Text Available Active suspension has not been popularized for high energy consumption. To address this issue, this paper introduces the concept of a new kind of suspension. The linear motor is considered to be integrated into an adjustable shock absorber to form the hybrid active semiactive suspension (HASAS. To realize the superiority of HASAS, its energy consumption and regeneration mechanisms are revealed. And the system controller which is composed of linear quadratic regulator (LQR controller, mode decision and switch controller, and the sliding mode control based thrust controller is developed. LQR controller is designed to maintain the suspension control objectives, while mode decision and switch controller decides the optimal damping level to tune motor thrust. The thrust controller ensures motor thrust tracking. An adjustable shock absorber with three regulating levels to be used in HASAS is trial produced and tested to obtain its working characteristics. Finally, simulation analysis is made with the experimental three damping characteristics. The impacts of adjustable damping on the motor force and energy consumption are investigated. Simulation results demonstrate the advantages of HASAS in energy conservation with various suspension control objectives. Even self-powered active control and energy regenerated to the power source can be realized.

  8. Process control plan for tank 241-SY-101 surface level rise remediation

    Energy Technology Data Exchange (ETDEWEB)

    ESTEY, S.D.

    1999-06-29

    The tank 241-SY-101 transfer system was conceived and designed to address the immediate needs presented by rapidly changing waste conditions in tank 241-SY-101. Within the past year or so, the waste in this tank has exhibited unexpected behavior in the form of rapidly increasing crust growth. The Process Control Plan (PCP), HNF-4264, was written to translate high-level guidance and regulatory criteria and express it in terms of operating instructions for the waste transfer system. These controls include: (1) Tank Farm Operations Administrative Controls developed in response to DOE-ORP direction reg,arding supplemental controls placed upon tank 241-SY-101 surface level rise remediation activities specifically involving waste transfer activities. (2) Authorization Basis controls (Basis for Interim Operation (BIO)/Technical Safety Requirements (TSRs)) and supplemental DOE direction. (3) Environmental, Industrial Hygiene and Safety controls. (4) Operating Specification Document (OSD) controls. (5) Good operating practices. Included in the document are descriptions of tank conditions, waste conditions, major equipment, and a high-level overview of the system and the line-ups in which it operates. Primarily, the PCP addresses how the waste transfer will be managed, defining the monitoring and control methods including material balances to determine the progress and to define completion criteria for the transfer. The actual plant modifications and waste transfer will be authorized and controlled by plant procedures.

  9. Serum Chemerin Levels in relation to Osteoporosis and Bone Mineral Density: A Case-Control Study

    Directory of Open Access Journals (Sweden)

    Jing He

    2015-01-01

    Full Text Available Background. To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD. Methods. An age- and gender-matched case-control study was conducted. Pearson’s correlation test was performed to investigate the relationship between serum chemerin levels and BMD. Results. There were 93 patients included in the osteoporosis group and 93 matched controls. Serum chemerin level was significantly higher in patients with osteoporosis (87.27±5.80 ng/mL than patients in control (71.13±5.12 ng/mL (P<0.01. There was a negative correlation between femoral bone mineral density and chemerin in both groups (R=-0.395, P<0.01 in osteoporosis group; R=-0.680, P<0.01 in control and also a negative correlation between lumbar bone mineral density with chemerin in both groups (R=-0.306, P<0.01 in osteoporosis group; R=-0.362, P<0.01 in control. Conclusions. Patients with osteoporosis presented a higher level of serum chemerin, which witnessed an inverse correlation with BMD. Further studies are needed to explore the role of chemerin in the pathophysiology of osteoporosis.

  10. Development of a Low-Level Control System for the ROV Visor3

    Directory of Open Access Journals (Sweden)

    Santiago Rúa

    2016-01-01

    Full Text Available This paper addresses the development of the simulation of the low-level control system for the underwater remotely operated vehicle Visor3. The 6-DOF mathematical model of Visor3 is presented using two coordinated systems: Earth-fixed and body-fixed frames. The navigation, guidance, and control (NGC structure is divided into three layers: the high level or the mission planner; the mid-level or the path planner; and the low level formed by the navigation and control systems. The nonlinear model-based observer is developed using the extended Kalman filter (EKF which uses the linearization of the model to estimate the current state. The behavior of the observer is verified through simulations using Simulink®. An experiment was conducted with a trajectory that describes changes in the x and y and yaw components. To accomplish this task, two algorithms are compared: a multiloop PID and PID with gravity compensation. These controllers and the nonlinear observer are tested using the 6-DOF mathematical model of Visor3. The control and navigation systems are a fundamental part of the low-level control system that will allow Visor3’s operators to take advantage of more advanced vehicle’s capabilities during inspection tasks of port facilities, hydroelectric dams, and oceanographic research.

  11. Developmental kinesiology: three levels of motor control in the assessment and treatment of the motor system.

    Science.gov (United States)

    Kobesova, Alena; Kolar, Pavel

    2014-01-01

    Three levels of sensorimotor control within the central nervous system (CNS) can be distinguished. During the neonatal stage, general movements and primitive reflexes are controlled at the spinal and brain stem levels. Analysis of the newborn's spontaneous general movements and the assessment of primitive reflexes is crucial in the screening and early recognition of a risk for abnormal development. Following the newborn period, the subcortical level of the CNS motor control emerges and matures mainly during the first year of life. This allows for basic trunk stabilization, a prerequisite for any phasic movement and for the locomotor function of the extremities. At the subcortical level, orofacial muscles and afferent information are automatically integrated within postural-locomotor patterns. Finally, the cortical (the highest) level of motor control increasingly becomes activated. Cortical control is important for the individual qualities and characteristics of movement. It also allows for isolated segmental movement and relaxation. A child with impaired cortical motor control may be diagnosed with developmental dyspraxia or developmental coordination disorder. Human ontogenetic models, i.e., developmental motor patterns, can be used in both the diagnosis and treatment of locomotor system dysfunction. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Hierarchical Control and Skilled Typing: Evidence for Word-Level Control over the Execution of Individual Keystrokes

    Science.gov (United States)

    Crump, Matthew J. C.; Logan, Gordon D.

    2010-01-01

    Routine actions are commonly assumed to be controlled by hierarchically organized processes and representations. In the domain of typing theories, word-level information is assumed to activate the constituent keystrokes required to type each letter in a word. We tested this assumption directly using a novel single-letter probe technique. Subjects…

  13. Shop Floor-Level Control of Manufacturing Companies: An Interview Study in Finland

    Directory of Open Access Journals (Sweden)

    Tokola Henri

    2015-02-01

    Full Text Available This paper publishes the results of interviews regarding shop-floor-level control of 18 Finnish manufacturing companies. The interviews had 17 open questions relating to demand characteristics, shop floor-level control issues, production flexibility, inventory control, and potential development areas. In order to get insights from the interviews, this paper analyses the answers from the interviews and categorises them into typical answers. The companies that were interviewed are also categorised as small companies with their own end products, subcontractors, or large companies with their own end products, and the emphasis of the analysis is on how companies differ in their shop floor-level control. The results show that different types of companies have different characteristics. Small companies are characterised by constant workflow, seasonal trends in demand, and the use of forecasts. Subcontractors have great daily variation in their demand and processing times. Large companies tend to focus on inventory issues.

  14. Availability verification of information for human system interface in automatic SG level control using activity diagram

    Energy Technology Data Exchange (ETDEWEB)

    Nuraslinda, Anuar; Kim, Dong Young; Kim, Jong Hyun [KEPCO International Nuclear Graduate School, Uljugun (Korea, Republic of)

    2012-10-15

    Steam Generator (SG) level control system in OPR 1000 is one of representative automatic systems that falls under the Supervisory Control level in Endsley's taxonomy. Supervisory control of automated systems is classified as a form of out of the loop (OOTL) performance due to passive involvement in the systems operation, which could lead to loss of situation awareness (SA). There was a reported event, which was caused by inadequate human automation communication that contributed to an unexpected reactor trip in July 2005. A high SG level trip occurred in Yeonggwang (YGN) Unit 6 Nuclear Power Plant (NPP) due to human operator failure to recognize the need to change the control mode of the economizer valve controller (EVC) to manual mode during swap over (the transition from low power mode to high power mode) after the loss of offsite power (LOOP) event was recovered. This paper models the human system interaction in NPP SG level control system using Unified Modeling Language (UML) Activity Diagram. Then, it identifies the missing information for operators in the OPR1000 Main Control Room (MCR) and suggests some means of improving the human system interaction.

  15. Plasma paraoxonase, oxidative status level, and their relationship with asthma control test in children with asthma.

    Science.gov (United States)

    Emin, O; Hasan, A; Rusen, D M

    2015-01-01

    Assessment of asthma with a control test has been suggested as a relevant approach in recent years. However, no biomarker of systemic inflammation has been included in the assessment of asthma control. To evaluate plasma paraoxonase (PON1), total oxidant status (TOS), and total antioxidant status (TAS) levels in children with asthma according to the disease control, and the performance in the identification of uncontrolled patients. Stable asthmatic children (n=85) and healthy controls (n=55) were recruited for this study. Blood samples were collected for plasma PON1, TOS, and TAS measurements. Any contributing factors that may affect plasma PON1, TAS, and TOS levels were excluded from both groups. The diagnostic potential of these measures was evaluated using receiver operating characteristic (ROC) analysis. Comparing the asthmatic children with the control group, plasma TAS and TOS levels were significantly higher (TAS; 6.9 ± 2.1, 1.05 ± 0.32, Pasthma, respectively. Asthma Control Test (ACT) presented an AUC of 0.972 for the identification of uncontrolled asthma. PON1 and TOS levels may be systemic markers of uncontrolled asthma in children. Combined use of these two biomarkers with asthma control test may identify patients with uncontrolled asthma in children. Copyright © 2014 SEICAP. Published by Elsevier Espana. All rights reserved.

  16. Association of low density lipoprotein levels and glycaemic control in type-2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Yathish TR.

    2010-01-01

    Full Text Available Earlier diabetes mellitus (DM was thought to be a disease of carbohydrate metabolism. Looking at the effects of insulin deficiency on carbohydrate and lipid metabolism, diabetes mellitus is now being called more a disease of lipid metabolism than carbohydrate metabolism. A cross-sectional study was conducted during March 2005 to March 2006 to study the low-density lipoproteins (LDL levels in diabetes mellitus and its relation to glycaemic control. LDL levels were estimated. Comparison of lipid levels were made between group of diabetic patients with glycated hemoglobin less than 8.0% and a group of diabetic patients with glycated hemoglobin more than 8.0% and the controls. The lipid fractions i.e. total cholesterol (TC, triglycerides (TG, and low-density lipoprotein (LDL levels were higher in the poorly controlled diabetes patients as compared to well controlled diabetic patients and nondiabetic patients. Increased levels of low-density lipoprotein may be a contributory factor to the high risk of atherosclerosis induced coronary artery disease observed in diabetes mellitus patients. Reduction of blood glucose levels is likely to reduce low density lipoprotein levels and the risk of complication, with the lowest risk being in those with glycosylated hemoglobin values in the normal range ie. Less than 8.0%

  17. HIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles

    Science.gov (United States)

    Bello, Gonzalo; Teixeira, Sylvia LM; Vorsatz, Carla; Babic, Dunja; Sharkey, Mark; Grinsztejn, Beatriz; Veloso, Valdilea; Stevenson, Mario; Morgado, Mariza G

    2015-01-01

    Background The mechanisms behind natural control of HIV replication are still unclear, and several studies pointed that elite controllers are a heterogeneous group. Methods We performed analyses of virologic, genetic and immunologic parameters of HIV-1 controllers groups: 1) Elite Controllers (EC; VL <80 copies/mL); 2) Ebbing Elite Controllers (EEC; transient viremia/blips); and Viremic Controllers (VC; detectable viremia <5,000 copies/mL). Untreated non-controllers (NC), patients under suppressive HAART and HIV-1 negative individuals were analyzed as controls. Results Total and integrated HIV-1 DNA for EC were significantly lower than for NC and HAART groups. 2-LTR circles were detected in EEC (3/5) and VC (6/7) but not in EC. While EC and EEC maintain normal T cell counts over time, some VC displayed negative CD4+ T cells slopes. VC and EEC showed a higher percentage of activated CD8+ T cells and microbial translocation than HIV-1 negative controls. EC displayed a weaker Gag/Nef IFN-γ T cell response and a significantly lower proportion of anti-HIV IgG antibodies than EEC, VC and NC groups. Conclusion Transient/persistent low level viremia in HIV controllers may have an impact on immunologic and virologic profiles. Classify HIV controllers patients taking into account their virologic profile may decrease the heterogeneity of HIV controllers cohorts, which may help to clarify the mechanisms associated to the elite control of HIV. PMID:25564106

  18. Comparative study of different control techniques for the regulation of blood glucose level in diabetic patients.

    Science.gov (United States)

    Ibbini, Mohammed S

    2009-01-01

    Blood glucose regulation is of a great concern for insulin-dependant patients with excessive glucose in blood (hyperglycaemia), or low glucose profile (hypoglycaemia) due to excess insulin delivery. Both conditions can cause dangerous complications for diabetic patients, and hence glucose regulation in blood is of prime importance. Insulin pumps are used to deliver insulin in small quantities, allowing the glucose level to remain as close as possible to that of non-diabetics (near 100 mg dl(-1)). Different control techniques are used to maintain the glucose level and most of them depend on an exact mathematical or empirical model of insulin-glucose interaction. Recently, we have proposed different controllers that are based on fuzzy logic and so do not use mathematical modelling, which in general is nonlinear, complex and suffers from uncertainties. PI fuzzy controllers are physically related to classical PI and PID controllers, which are extremely popular. The parameter settings of classical and fuzzy logic controllers are based on deep common physical background. In this manuscript, a comparative study is proposed to evaluate the use of fuzzy logic controllers over other conventional controllers such as PI and PID controllers to maintain the blood glucose level within a normoglycaemic average especially when a diabetic patient is subjected to different conditions.

  19. Use of EPICS for High-Level Control of SNS Conventional Facilities

    CERN Document Server

    Munro, J K; Williams, E L; Nypaver, D J; Kasemir, K U; Meyer, R D

    2001-01-01

    The SNS Project intends to integrate Conventional Facility Controls with its EPICS-based Accelerator and Target Control Systems. EPICS will therefore be used to provide distributed high-level access to all subsystems of the SNS conventional facilities, including cooling water towers, chilled water, de-ionized water, HVAC, waste processing, and power monitoring. EPICS will provide operator displays and high-level control for more than 1000 process variables. EPICS support will be provided by four IOCs using PowerPC-based VMEbus controllers . Low-level control will be provided by Allen-Bradley ControlLogix PLCs that will communicate among themselves using ControlNet and with EPICS using EtherNet/IP [2]. Both the PLC layer and the EPICS layer will be implemented by an industrial supplier. File server support will be Linux-based and Concurrent Versions System (CVS) will be used to manage version control, both for EPICS and for PLC program and configuration files. All system process variable names, hardware, softw...

  20. Tri-level programming model for combined urban traffic signal control and traffic flow guidance

    Institute of Scientific and Technical Information of China (English)

    孙智源; 陆化普; 屈闻聪

    2016-01-01

    In order to balance the temporal-spatial distribution of urban traffic flow, a model is established for combined urban traffic signal control and traffic flow guidance. With consideration of the wide use of fixed signal control at intersections, traffic assignment under traffic flow guidance, and dynamic characteristics of urban traffic management, a tri-level programming model is presented. To reflect the impact of intersection delay on traffic assignment, the lower level model is set as a modified user equilibrium model. The middle level model, which contains several definitional constraints for different phase modes, is built for the traffic signal control optimization. To solve the problem of tide lane management, the upper level model is built up based on nonlinear 0-1 integer programming. A heuristic iterative optimization algorithm (HIOA) is set up to solve the tri-level programming model. The lower level model is solved by method of successive averages (MSA), the middle level model is solved by non-dominated sorting genetic algorithm II (NSGA II), and the upper level model is solved by genetic algorithm (GA). A case study is raised to show the efficiency and applicability of the proposed modelling and computing method.

  1. Robust Proportional Integral Control of Water Level in an Irrigation Main Canal

    Directory of Open Access Journals (Sweden)

    Ybrain Hernández López

    2015-07-01

    Full Text Available Nowadays In this paper, the design of a robust PI controller for effective level control in the second poolof the irrigation main canal Güira de Melena is developed. A mathematical model that adequately describesthe dynamic behavior of the plant under study is obtained from system identification procedure.This model is characterized by its simplicity (first order with time delay. The robustness analysis of thedesigned PI controller vs parametric variations of the obtained mathematical model showed satisfactoryresults, and therefore the implementation of this controller is validated.

  2. Representation and Integration: Combining Robot Control, High-Level Planning, and Action Learning

    DEFF Research Database (Denmark)

    Petrick, Ronald; Kraft, Dirk; Mourao, Kira;

    We describe an approach to integrated robot control, high-level planning, and action effect learning that attempts to overcome the representational difficulties that exist between these diverse areas. Our approach combines ideas from robot vision, knowledgelevel planning, and connectionist machine......-level action specifications, suitable for planning, from a robot’s interactions with the world. We present a detailed overview of our approach and show how it supports the learning of certain aspects of a high-level lepresentation from low-level world state information....

  3. Dynamic Output Feedback Power-Level Control for the MHTGR Based On Iterative Damping Assignment

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2012-06-01

    Full Text Available Because of its strong inherent safety features and high outlet temperature, the modular high temperature gas-cooled nuclear reactor (MHTGR is already seen as the central part of the next generation of nuclear plants. Such power plants are being considered for industrial applications with a wide range of power levels, and thus power-level control is an important technique for their efficient and stable operation. Stimulated by the high regulation performance provided by nonlinear controllers, a novel dynamic output-feedback nonlinear power-level regulator is developed in this paper based on the technique of iterative damping assignment (IDA. This control strategy can provide the L2 disturbance attenuation performance under modeling uncertainty or exterior disturbance, and can also guarantee the globally asymptotic closed-loop stability without uncertainty and disturbance. This newly built control strategy is then applied to the power-level regulation of the HTR-PM plant, and numerical simulation results show both the feasibility and high performance of this newly-built control strategy. Furthermore, the relationship between the values of the parameters and the performance of this controller is not only illustrated numerically but also analyzed theoretically.

  4. Direct Torque Control for Three-Level Neutral Point Clamped Inverter-Fed Induction Motor Drive

    Directory of Open Access Journals (Sweden)

    M. K. Sahu

    2012-04-01

    Full Text Available Direct torque control (DTC is a control technique in AC drive systems to obtain high performance torque control. The classical DTC drive contains a pair of hysteresis comparators and suffers from variable switching frequency and high torque ripple. These problems can be solved by using space vector depending on the reference torque and flux. In this paper the space vector modulation technique is applied to the three-level Neutral Point Clamped (NPC inverter control in the proposed DTC-based induction motor drive system, resulting to a significant reduce of torque ripple. Three-level neutral point clamped inverters have been widely used in medium voltage applications. This type of inverters have several advantages over standard two-level VSI, such as greater number of levels in the output voltage waveforms, less harmonic distortion in voltage and current waveforms and lower switching frequencies. This paper emphasizes the derivation of switching states using the Space Vector Pulse Width Modulation (SVPWM technique. The control scheme is implemented using Matlab/Simulink. Experimental results using dSPACE validate the steady-state and the dynamic performance of the proposed control strategy.

  5. Relation between blood vitamin B12 levels with premature ejaculation: case-control study.

    Science.gov (United States)

    Kadihasanoglu, M; Kilciler, M; Kilciler, G; Yucetas, U; Erkan, E; Karabay, E; Toktas, M G; Kendirci, M

    2016-09-29

    The aim of this study was to investigate whether vitamin B12 levels are associated with premature ejaculation (PE). A total of 109 subjects (56 PE and 53 controls) were included in this study. PE was defined as self-reported intravaginal ejaculatory latency time (IELT) based on the Diagnostic and Statistical Manual of Mental Disorders IV criteria and those who had had an IELT of premature ejaculation diagnostic tool (PEDT), International Index of Erectile Function (IIEF) and Beck Depression Inventory (BDI). The vitamin 12 levels were measured in all subjects. The mean age between the PE and controls was comparable (p = .084). Mean IIEF and BDI scores between the two groups did not statistically differ. The mean IELT values in the PE group were significantly lower than in the control group (p < .0001). PE patients reported significantly lower vitamin B12 levels compared with the controls (213.14 vs. 265.89 ng ml(-1) ; p < .001). The ROC analysis showed a significant correlation between the diagnosis of PE and lower vitamin B12 levels. This study has demonstrated that lower vitamin B12 levels are associated with the presence of PE. This work also shows a strong correlation between vitamin B12 levels and the PEDT scores as well as the IELT values.

  6. Capacity determination of a battery energy storage system based on the control performance of load leveling and voltage control

    Directory of Open Access Journals (Sweden)

    Satoru Akagi

    2016-01-01

    Full Text Available This paper proposes a method to determine the combined energy (kWh and power (kW capacity of a battery energy storage system and power conditioning system capacity (kVA based on load leveling and voltage control performances. Through power flow calculations, a relationship between the capacity combination and the control performance is identified and evaluated. A tradeoff relationship between the capacity combination and control performance is confirmed, and the proper capacity combination for operation is determined based on the evaluated relationship. In addition, the control performance of the capacity combination is evaluated through the power flow calculation, confirming that the proposed method is effective for determining the optimized capacity combination.

  7. Performance of a Two-Level Call Admission Control Scheme for DS-CDMA Wireless Networks

    Directory of Open Access Journals (Sweden)

    Abraham O. Fapojuwo

    2007-11-01

    Full Text Available We propose a two-level call admission control (CAC scheme for direct sequence code division multiple access (DS-CDMA wireless networks supporting multimedia traffic and evaluate its performance. The first-level admission control assigns higher priority to real-time calls (also referred to as class 0 calls in gaining access to the system resources. The second level admits nonreal-time calls (or class 1 calls based on the resources remaining after meeting the resource needs for real-time calls. However, to ensure some minimum level of performance for nonreal-time calls, the scheme reserves some resources for such calls. The proposed two-level CAC scheme utilizes the delay-tolerant characteristic of non-real-time calls by incorporating a queue to temporarily store those that cannot be assigned resources at the time of initial access. We analyze and evaluate the call blocking, outage probability, throughput, and average queuing delay performance of the proposed two-level CAC scheme using Markov chain theory. The analytic results are validated by simulation results. The numerical results show that the proposed two-level CAC scheme provides better performance than the single-level CAC scheme. Based on these results, it is concluded that the proposed two-level CAC scheme serves as a good solution for supporting multimedia applications in DS-CDMA wireless communication systems.

  8. Performance of a Two-Level Call Admission Control Scheme for DS-CDMA Wireless Networks

    Directory of Open Access Journals (Sweden)

    Fapojuwo Abraham O

    2007-01-01

    Full Text Available We propose a two-level call admission control (CAC scheme for direct sequence code division multiple access (DS-CDMA wireless networks supporting multimedia traffic and evaluate its performance. The first-level admission control assigns higher priority to real-time calls (also referred to as class 0 calls in gaining access to the system resources. The second level admits nonreal-time calls (or class 1 calls based on the resources remaining after meeting the resource needs for real-time calls. However, to ensure some minimum level of performance for nonreal-time calls, the scheme reserves some resources for such calls. The proposed two-level CAC scheme utilizes the delay-tolerant characteristic of non-real-time calls by incorporating a queue to temporarily store those that cannot be assigned resources at the time of initial access. We analyze and evaluate the call blocking, outage probability, throughput, and average queuing delay performance of the proposed two-level CAC scheme using Markov chain theory. The analytic results are validated by simulation results. The numerical results show that the proposed two-level CAC scheme provides better performance than the single-level CAC scheme. Based on these results, it is concluded that the proposed two-level CAC scheme serves as a good solution for supporting multimedia applications in DS-CDMA wireless communication systems.

  9. Nonlinear Adaptive Dynamic Output-Feedback Power-Level Control of Nuclear Heating Reactors

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2013-01-01

    Full Text Available Due to the high safety performance of small nuclear reactors, there is a promising future for small reactors. Nuclear heating reactor (NHR is a small reactor that has many advanced safety features such as the integrated arrangement, natural circulation at any power levels, self-pressurization, hydraulic control rod driving, and passive residual heating removing and can be applied to the fields of district heating, seawater desalination, and electricity production. Since the NHR dynamics has strong nonlinearity and uncertainty, it is meaningful to develop the nonlinear adaptive power-level control technique. From the idea of physically based control design method, a novel nonlinear adaptive power-level control is given for the NHR in this paper. It is theoretically proved that this newly built controller does not only provide globally asymptotic closed-loop stability but is also adaptive to the system uncertainty. Numerical simulation results show the feasibility of this controller and the relationship between the performance and controller parameters.

  10. HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles.

    Science.gov (United States)

    Côrtes, Fernanda H; Passaes, Caroline Pb; Bello, Gonzalo; Teixeira, Sylvia Lm; Vorsatz, Carla; Babic, Dunja; Sharkey, Mark; Grinsztejn, Beatriz; Veloso, Valdilea; Stevenson, Mario; Morgado, Mariza G

    2015-04-01

    The mechanisms behind natural control of HIV replication are still unclear, and several studies pointed that elite controllers (ECs) are a heterogeneous group. We performed analyses of virologic, genetic, and immunologic parameters of HIV-1 controllers groups: (1) ECs (viral load, <80 copies/mL); (2) ebbing elite controllers (EECs; transient viremia/blips); and viremic controllers (VCs; detectable viremia, <5000 copies/mL). Untreated noncontrollers (NCs), patients under suppressive highly active antiretroviral therapy (HAART), and HIV-1-negative individuals were analyzed as controls. Total and integrated HIV-1 DNA for EC were significantly lower than for NC and HAART groups. 2-LTR circles were detected in EEC (3/5) and VC (6/7) but not in EC. Although EC and EEC maintain normal T-cell counts over time, some VC displayed negative CD4 T-cell slopes. VC and EEC showed a higher percentage of activated CD8 T cells and microbial translocation than HIV-1-negative controls. EC displayed a weaker Gag/Nef IFN-γ T-cell response and a significantly lower proportion of anti-HIV IgG antibodies than EEC, VC, and NC groups. Transient/persistent low-level viremia in HIV controllers may have an impact on immunologic and virologic profiles. Classified HIV controller patients taking into account their virologic profile may decrease the heterogeneity of HIV controllers cohorts, which may help to clarify the mechanisms associated to the elite control of HIV.

  11. Multi-level manual and autonomous control superposition for intelligent telerobot

    Science.gov (United States)

    Hirai, Shigeoki; Sato, T.

    1989-01-01

    Space telerobots are recognized to require cooperation with human operators in various ways. Multi-level manual and autonomous control superposition in telerobot task execution is described. The object model, the structured master-slave manipulation system, and the motion understanding system are proposed to realize the concept. The object model offers interfaces for task level and object level human intervention. The structured master-slave manipulation system offers interfaces for motion level human intervention. The motion understanding system maintains the consistency of the knowledge through all the levels which supports the robot autonomy while accepting the human intervention. The superposing execution of the teleoperational task at multi-levels realizes intuitive and robust task execution for wide variety of objects and in changeful environment. The performance of several examples of operating chemical apparatuses is shown.

  12. Relationship of circulating hyaluronic acid levels to disease control in asthma and asthmatic pregnancy.

    Science.gov (United States)

    Eszes, Noémi; Toldi, Gergely; Bohács, Anikó; Ivancsó, István; Müller, Veronika; Rigó, János; Losonczy, György; Vásárhelyi, Barna; Tamási, Lilla

    2014-01-01

    Uncontrolled asthma is a risk factor for pregnancy-related complications. Hyaluronic acid (HA), a potential peripheral blood marker of tissue fibrosis in various diseases, promotes eosinophil survival and plays a role in asthmatic airway inflammation as well as in physiological processes necessary to maintain normal pregnancy; however the level of circulating HA in asthma and asthmatic pregnancy is unknown. We investigated HA levels in asthmatic patients (N = 52; asthmatic pregnant (AP) N = 16; asthmatic non-pregnant (ANP) N = 36) and tested their relationship to asthma control. Serum HA level was lower in AP than in ANP patients (27 [24.7-31.55] vs. 37.4 [30.1-66.55] ng/mL, p = 0.006); the difference attenuated to a trend after its adjustment for patients' age (p = 0.056). HA levels and airway resistance were positively (r = 0.467, p = 0.004), HA levels and Asthma Control Test (ACT) total score inversely (r = -0.437, p = 0.01) associated in ANP patients; these relationships remained significant even after their adjustments for age. The potential value of HA in the determination of asthma control was analyzed using ROC analysis which revealed that HA values discriminate patients with ACT total score ≥20 (controlled patients) and asthma control, as it correlates with airway resistance and has good sensitivity in the detection of impaired asthma control. Decrease of HA level in pregnancy may be the consequence of pregnancy induced immune tolerance.

  13. A case control study of premorbid and currently reported physical activity levels in chronic fatigue syndrome

    Directory of Open Access Journals (Sweden)

    Buchwald Dedra

    2006-11-01

    Full Text Available Abstract Background Patients with chronic fatigue syndrome typically report high levels of physical activity before becoming ill. Few studies have examined premorbid and current activity levels in chronically fatigued patients. Methods In a case-control study, 33 patients with chronic, unexplained, disabling fatigue attending a university-based clinic specializing in fatigue were compared to 33 healthy, age- and sex-matched controls. Patients rated their activity levels before their illness and currently, using scales designed for this purpose. Controls reported their level of activity of 2 years previously and currently. Chi-square analyses, Student's t tests, and Wilcoxon signed rank tests were used in pair matched analyses. Results Compared to healthy controls, patients with chronic, unexplained fatigue rated themselves as more active before their illness (p ≤ 0.001 and less active currently (p ≤ 0.001. The patients also reported they currently stood or walked less than the controls (median [inter-quartile range] = 4 2345 versus 9 [7.5–12] hours, p ≤ 0.001, and spent more time reclining (median [inter-quartile range] = 12 10111213141516 versus 8 [8–9.5] hours, p ≤ 0.001. These differences remained significant for the subset of patients who met strict criteria for chronic fatigue syndrome or fibromyalgia. Conclusion Patients with chronic, unexplained, disabling fatigue reported being more active before becoming ill than healthy controls. This finding could be explained by greater premorbid activity levels that could predispose to illness, or by an overestimation of previous activity. Either possibility could influence patients' perceptions of their current activity levels and their judgments of recovery. Perceived activity should be addressed as part of management of the illness.

  14. Measurement and AFPS control of molten steel level in strip casting

    Institute of Scientific and Technical Information of China (English)

    Liye Zhu; Tihua Wu; Yuan Fang

    2005-01-01

    The measurement and control of the molten steel level are studied, which affect the quality of strip surface in strip casting.A system of molten steel measurement with a CCD (Charge Coupled Devices) sensor is designed, real-time measured data are given and its precision is analyzed. The level fluctuation model is derived, and an adaptive fuzzy-PID controller with supervisory control (AFPS) is proposed. The stability of the system is proved using Lyapunov theorem, and the simulation results are given when the model, the casting speed and the roll gap change. It is suggested that this kind of coupled nonlinear and time varying system is stable and robust using the designed AFPS controller.

  15. Current Sensorless Control Algorithm for Single-Phase Three-Level NPC Inverter

    Directory of Open Access Journals (Sweden)

    Suzdalenko Alexander

    2014-12-01

    Full Text Available The current measurement is becoming a challenging task in power converters operating at high switching frequencies, moreover traditional control system requires two control loops - first (slow regulates DC-link voltage, second (fast controls the shape of current, that all together results in complicated transfer function and long transition periods. The current sensorless control (CSC allows neglecting the mentioned problems. This research for the first time presents the solution of CSC implementation in single-phase three-level neutral point clamped inverter. Mathematical equations were defined for inductor current peaks and transistor conduction time during discontinuous and continuous conduction modes, as well as major problem of current fitting between different voltage levels (consequently with different current peak-to-peak values was solved, providing two solutions - pre-fitting and post-fitting trajectories. The verification of our theoretical assumptions and analytical equations was confirmed by the simulation analysis. Challenges of real experiments are discussed in the conclusion.

  16. Automated Liquid-Level Control of a Nutrient Reservoir for a Hydroponic System

    Science.gov (United States)

    Smith, Boris; Asumadu, Johnson A.; Dogan, Numan S.

    1997-01-01

    A microprocessor-based system for control of the liquid level of a nutrient reservoir for a plant hydroponic growing system has been developed. The system uses an ultrasonic transducer to sense the liquid level or height. A National Instruments' Multifunction Analog and Digital Input/Output PC Kit includes NI-DAQ DOS/Windows driver software for an IBM 486 personal computer. A Labview Full Development system for Windows is the graphical programming system being used. The system allows liquid level control to within 0.1 cm for all levels tried between 8 and 36 cm in the hydroponic system application. The detailed algorithms have been developed and a fully automated microprocessor based nutrient replenishment system has been described for this hydroponic system.

  17. Correlation of Serum Zinc Level with Simple Febrile Seizures: A Hospital based Prospective Case Control Study

    Directory of Open Access Journals (Sweden)

    Imran Gattoo

    2015-04-01

    Full Text Available Background: Febrile seizures are one of the most common neurological conditions of childhood. It seems that zinc deficiency is associated with increased risk of febrile seizures.Aim: To estimate the serum Zinc level in children with simple Febrile seizures and to find the correlation between serum zinc level and simple Febrile seizures.Materials and Methods: The proposed study was a hospital based prospective case control study which included infants and children aged between 6 months to 5 years, at Post Graduate Department of Pediatrics, (SMGS Hospital, GMC Jammu, northern India. A total of 200 infants and children fulfilling the inclusion criteria were included. Patients were divided into 100(cases in Group A with simple febrile seizure and 100(controls in Group B of children with acute febrile illness without seizure. All patients were subjected to detailed history and thorough clinical examination followed by relevant investigations.Results: Our study had slight male prepondance of 62% in cases and 58% in controls . Mean serum zinc level in cases was 61.53±15.87 ugm/dl and in controls it was 71.90+18.50 ugm/dl .Serum zinc level was found significantly low in cases of simple febrile seizures as compaired to controls ,with p value of

  18. Quantifying controlled productive knowledge of collocations across proficiency and word frequency levels

    Directory of Open Access Journals (Sweden)

    Déogratias Nizonkiza

    2012-10-01

    Full Text Available The present study explores the relationship between controlled productive knowledge of collocations and L2 proficiency, the role of frequency in controlled productive knowledge of collocations, and the quantifiability of controlled productive collocational knowledge growth alongside L2 proficiency and word frequency levels. A proficiency measure and a productive collocation test modelled on Laufer and Nation (1999 were presented to Belgian and Burundian English majors. The results show that scores on both tests distinguish between proficiency levels and, furthermore, highly correlate. This suggests that controlled productive knowledge of collocations develops as proficiency increases, supporting earlier studies (Boers, Eyckmans, Kappel, Stengers, & Demecheleer, 2006; Bonk, 2001; Eyckmans, Boers, & Demecheleer, 2004; Gitsaki, 1999 that had established a relationship between collocational knowledge and L2 proficiency. The results also show that the more frequent the collocations, the better they are known, which highlights the crucial role played by frequency in knowing words (Nation & Beglar, 2007. Furthermore, the number of collocations added can be quantified and we observe moderat egains at beginner and advanced levels, and impressive gains at intermediate levels. This supports and extends Laufer’s (1998 and Zhong and Hirsh’s (2009 findings and lays basic ground work for teaching collocations, the amount of which should increase with proficiency levels.

  19. Fighting corruption when existing corruption-control levels count : what do wealth effects tell us?

    OpenAIRE

    Simplice A, Asongu

    2012-01-01

    Why are some nations more effective at battling corruption than others? Are there different determinants in the fight against corruption across developing nations? How do wealth effects play-out when existing corruption-control levels matter in the corruption battle? To investigate these concerns we examine the determinants of corruption-control throughout the conditional distribution of the fight against corruption. The following broad findings are established. (1) Population growth is a(an)...

  20. Case–Control Study of Blood Lead Levels and Attention Deficit Hyperactivity Disorder in Chinese Children

    OpenAIRE

    Wang, Hui-Li; Chen, Xiang-Tao; Yang, Bin; Ma, Fang-Li; Wang, Shu; Tang, Ming-liang; Hao, Ming-Gao; Ruan, Di-Yun

    2008-01-01

    Background Attention deficit/hyperactivity disorder (ADHD) and lead exposure are high-prevalence conditions among children. Objective Our goal was to investigate the association between ADHD and blood lead levels (BLLs) in Chinese children, adjusting for known ADHD risk factors and potential confounding variables. Methods We conducted a pair-matching case–control study with 630 ADHD cases and 630 non-ADHD controls 4–12 years of age, matched on the same age, sex, and socioeconomic status. The ...

  1. Water Level Loggers as a Low-Cost Tool for Monitoring of Stormwater Control Measures

    OpenAIRE

    Laura Toran

    2016-01-01

    Stormwater control measures (SCMs) are a key component of watershed health in urbanized areas. SCMs are used to increase infiltration and reduce discharge to streams or storm sewer systems during rain events. Monitoring is important for the evaluation of design and causes of failure in SCMs. However, the expense of monitoring means it is not always included in stormwater control planning. This study shows how low-cost water level loggers can be used to answer certain questions about SCM perfo...

  2. Fetal hemoglobin levels are related to metabolic control in diabetic subjects

    Directory of Open Access Journals (Sweden)

    Pardini V.C.

    1999-01-01

    Full Text Available We have investigated the relationship between fetal hemoglobin (HbF levels and metabolic control in subjects with insulin-dependent (N = 79 and non-insulin-dependent diabetes mellitus (N = 242. HbF and hemoglobin A1c (HbA1c levels were increased in subjects with type 1 and type 2 diabetes as compared to levels in nondiabetic individuals (P<0.0001, and were significantly higher in type 1 than in type 2 diabetes subjects. Lower levels of HbA1c and HbF were observed in type 2 diabetes subjects treated by diet, intermediate levels in those treated with oral hypoglycemic agents, and higher levels in those treated with insulin. HbF and HbA1c levels were correlated in type 1 diabetes (R2 = 0.57, P<0.0001 and type 2 diabetes (R2 = 0.58, P<0.0001 subjects. Following intense treatment, twelve diabetic patients showed significant improvement both in HbA1c and HbF values. We conclude that increased HbF levels reflect poor metabolic control in subjects with diabetes mellitus.

  3. Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls

    Directory of Open Access Journals (Sweden)

    White Timothy O

    2010-02-01

    Full Text Available Abstract Background High plasma cortisol levels can cause acute cognitive and neuropsychiatric dysfunction, and have been linked with delirium. CSF cortisol levels more closely reflect brain exposure to cortisol, but there are no studies of CSF cortisol levels in delirium. In this pilot study we acquired CSF specimens at the onset of spinal anaesthesia in patients undergoing hip fracture surgery, and compared CSF and plasma cortisol levels in delirium cases versus controls. Findings Delirium assessments were performed the evening before or on the morning of operation with a standard battery comprising cognitive tests, mental status assessments and the Confusion Assessment Method. CSF and plasma samples were obtained at the onset of the operation and cortisol levels measured. Twenty patients (15 female, 5 male aged 62 - 93 years were studied. Seven patients were diagnosed with delirium. The mean ages of cases (81.4 (SD 7.2 and controls (80.5 (SD 8.7 were not significantly different (p = 0.88. The median (interquartile range CSF cortisol levels were significantly higher in cases (63.9 (40.4-102.1 nmol/L than controls (31.4 (21.7-43.3 nmol/L; Mann-Whitney U, p = 0.029. The median (interquartile range of plasma cortisol was also significantly higher in cases (968.8 (886.2-1394.4 nmol/L, than controls (809.4 (544.0-986.4 nmol/L; Mann Whitney U, p = 0.036. Conclusions These findings support an association between higher CSF cortisol levels and delirium. This extends previous findings linking higher plasma cortisol and delirium, and suggests that more definitive studies of the relationship between cortisol levels and delirium are now required.

  4. UPFC converter-level control system using internally calculated system quantities for decoupling

    Energy Technology Data Exchange (ETDEWEB)

    Papic, I.; Zunko, P. [Ljubljana Univ., Faculty of Electrical Engineering, Ljubljana (Slovenia)

    2003-10-01

    The paper presents a Unified power flow controller (UPFC) converter-level control system which enables the device to track the changes in reference values of the active and reactive power flow through the transmission line, and of the reactive power exchange with the shunt branch. First, a co-ordinated control of both branches of the device is presented, where all quantities being controlled are also dynamically mutually decoupled. This is possible only if on-line values of input quantities are available in the controller. Under practical operating conditions, the input values are filtered and processed with certain delay, which means that they cannot be directly used for decoupling too. To overcome this problem, a modified control structure was formulated. It is based on the calculation of system quantities in the controller by using the mathematical model of the device. The decoupled UPFC control can significantly reduce interactions with other controls in the system. The derived control was tested with digital simulation (Author)

  5. A PI-fuzzy logic controller for the regulation of blood glucose level in diabetic patients.

    Science.gov (United States)

    Ibbini, M

    2006-01-01

    This manuscript investigates different fuzzy logic controllers for the regulation of blood glucose level in diabetic patients. While fuzzy logic control is still intuitive and at a very early stage, it has already been implemented in many industrial plants and reported results are very promising. A fuzzy logic control (FLC) scheme was recently proposed for maintaining blood glucose level in diabetics within acceptable limits, and was shown to be more effective with better transient characteristics than conventional techniques. In fact, FLC is based on human expertise and on desired output characteristics, and hence does not require precise mathematical models. This observation makes fuzzy rule-based technique very suitable for biomedical systems where models are, in general, either very complicated or over-simplistic. Another attractive feature of fuzzy techniques is their insensitivity to system parameter variations, as numerical values of physiological parameters are often not precise and usually vary from patient to another. PI and PID controllers are very popular and are efficiently used in many industrial plants. Fuzzy PI and PID controllers behave in a similar fashion to those classical controllers with the obvious advantage that the controller parameters are time dependant on the range of the control variables and consequently, result in a better performance. In this manuscript, a fuzzy PI controller is designed using a simplified design scheme and then subjected to simulations of the two common diabetes disturbances--sudden glucose meal and system parameter variations. The performance of the proposed fuzzy PI controller is compared to that of the conventional PID and optimal techniques and is shown to be superior. Moreover, the proposed fuzzy PI controller is shown to be more effective than the previously proposed FLC, especially with respect to the overshoot and settling time.

  6. Coherent control in strongly driven multi-level systems: quantum vs classical features

    Science.gov (United States)

    Ivanov, Misha; Bartram, David; Smirnova, Olga

    2012-08-01

    We look at wavepacket dynamics in multi-level systems driven by resonant two-colour fields. We show that control of this dynamics, performed by controlling the relative phase between the driving fields, can be mapped on a problem of molecular alignment and orientation on a plane. Changing the relative phase between the two colours corresponds to changing the angle between aligning and orienting fields. This map offers physically transparent qualitative and quantitative insight into the seemingly complex dynamics, including the analysis of quantum versus classical features of the two-colour coherent control.

  7. The impact of asthma control on salivary cortisol level in adult asthmatics.

    Science.gov (United States)

    Shin, Yoo Seob; Liu, Jing Nan; Kim, Joo-Hee; Nam, Young-Hee; Choi, Gil Soon; Park, Hae-Sim

    2014-09-01

    Asthma is a chronic disease causing psychological stress which leads to the activation of hypothalamus-pituitary-adrenal axis. The purpose of this study is to compare morning salivary cortisol levels in persistent asthma patients according to their disease severities and control status. Total 206 adult asthma patients were recruited from four university hospitals. Spirometry, questionnaire of Asthma Quality of Life (AQOL) and Asthma Control Test (ACT) were completed, and saliva samples were collected prospectively to measure morning cortisol level. The mean patient age was 56.5±15.3 years with mean asthma duration of 9.1±11.1 years. Sixty five patents (31.6%) were classified as mild persistent asthma, and 141 patients (68.4%) were classified as moderate persistent asthma according to the Expert Panel Report 3. The mean predicted FEV1 was 88.8%±18.4%, and the methacholine PC20 was 9.6±8.5 mg/mL in all study population. The mean ACT score for all patients was 19.9±3.6, and there were 71 (34.5%) patients in poorly controlled and 135 (65.5%) in well controlled asthma. The poorly controlled asthma patients were characterized by significantly lower FEV1 (84.6%±17.6% vs 91.1%±18.5%, P=0.018), lower AQOL scores (46.0±13.9 vs 73.8±26.3, Pcortisol levels (0.14±0.08 vs 0.18±0.11 µg/dL, P=0.04) compared to well controlled asthma. The ACT score was significantly related to salivary cortisol levels (P=0.034) after adjusting for age. There was no significant difference in salivary cortisol levels (0.17±0.12 vs 0.16±0.08, P=0.725) when analyzed according to the dose of used corticosteroid and lung function. Asthma control status affects morning salivary cortisol level. Measuring the morning salivary cortisol level might be a simple and new way to assess asthma control status.

  8. Lithium-ion battery cell-level control using constrained model predictive control and equivalent circuit models

    Energy Technology Data Exchange (ETDEWEB)

    Xavier, MA; Trimboli, MS

    2015-07-01

    This paper introduces a novel application of model predictive control (MPC) to cell-level charging of a lithium-ion battery utilizing an equivalent circuit model of battery dynamics. The approach employs a modified form of the MPC algorithm that caters for direct feed-though signals in order to model near-instantaneous battery ohmic resistance. The implementation utilizes a 2nd-order equivalent circuit discrete-time state-space model based on actual cell parameters; the control methodology is used to compute a fast charging profile that respects input, output, and state constraints. Results show that MPC is well-suited to the dynamics of the battery control problem and further suggest significant performance improvements might be achieved by extending the result to electrochemical models. (C) 2015 Elsevier B.V. All rights reserved.

  9. Electromagnetically induced transparency and controllable group velocity in a five-level atomic system

    Institute of Scientific and Technical Information of China (English)

    Lihui Jin; Shangqing Gong; Yueping Niu; Shiqi Jin

    2006-01-01

    @@ The optical properties of a five-level atomic system composed of a A-type four-level atomic and a tripod four-level atomic systems are investigated. It is found that the behaviors of electromagnetically induced transparency (EIT) and group velocity can be controlled by choosing appropriate parameters with the interacting dark resonances. In particular, when all the fields are on resonance, the slow light at the symmetric transparency windows with a much broader EIT width is obtained by tuning the intensity of the coupling field in comparison with its sub-system, which provides potential applications in quantum storage and retrieval of light.

  10. Model Predictive Wind Turbine Control with Move-Blocking Strategy for Load Alleviation and Power Leveling

    Science.gov (United States)

    Jassmann, U.; Dickler, S.; Zierath, J.; Hakenberg, M.; Abel, D.

    2016-09-01

    This contribution presents a Model Predictive Controller (MPC) with moveblocking strategy for combined power leveling and load alleviation in wind turbine operation with a focus on extreme loads. The controller is designed for a 3 MW wind turbine developed by W2E Wind to Energy GmbH and compared to a baseline controller, using a classic control scheme, which currently operates the wind turbine. All simulations are carried out with a detailed multibody simulation turbine model implemented in alaska/Wind. The performance of the two different controllers is compared using a 50-year Extreme Operation Gust event, since it is one of the main design drivers for the wind turbine considered in this work. The implemented MPC is able to level electrical output power and reduce mechanical loads at the same time. Without de-rating the achieved control results, a move-blocking strategy is utilized and allowed to reduce the computational burden of the MPC by more than 50% compared to a baseline MPC implementation. This even allows to run the MPC on a state of the art Programmable Logic Controller.

  11. Preprogrammed capillarity to passively control system-level sequential and parallel microfluidic flows.

    Science.gov (United States)

    Kim, Sung-Jin; Paczesny, Sophie; Takayama, Shuichi; Kurabayashi, Katsuo

    2013-06-01

    In microfluidics, capillarity-driven solution flow is often beneficial, owing to its inherently spontaneous motion. However, it is commonly perceived that, in an integrated microfluidic system, the passive capillarity control alone can hardly achieve well-controlled sequential and parallel flow of multiple solutions. Despite this common notion, we hereby demonstrate system-level sequential and parallel microfluidic flow processing by fully passive capillarity-driven control. After manual loading of solutions with a pipette, a network of microfluidic channels passively regulates the flow timing of the multiple solution menisci in a sequential and synchronous manner. Also, use of auxiliary channels and preprogramming of inlet-well meniscus pressure and channel fluidic conductance allow for controlling the flow direction of multiple solutions in our microfluidic system. With those components orchestrated in a single device chip, we show preprogrammed flow control of 10 solutions. The demonstrated system-level flow control proves capillarity as a useful means even for sophisticated microfluidic processing without any actively controlled valves and pumps.

  12. Development of Fuzzy Controller for Water Level in Stream Boiler Tank

    Directory of Open Access Journals (Sweden)

    Surachai Panich

    2010-01-01

    Full Text Available Problem statement: The process control of steam boiler is very popular used in the industrial. The temperature of the water is transferred directly by electrical heater. The pressure will increase based on the changing of the temperature. The purpose of the control is to change the opening set point for the valve when the temperature and pressure in the tank are changed. For this problem, we develop fuzzy algorithm to adjust the optimal percentage of valve open. Approach: In this study, the fuzzy control application was programmed in fuzzy control language in form of the function block using structure control language. The input information consisted of real variables in the form of measurable process variables, as well as set points. And the output variables were real variables in the form of correcting variables. Results: The fuzzy control was developed, which consists of two input variables, the degree of temperature and pressure in boiler tank measured by sensor. For fuzzy system of water level control, the algorithm is basically implemented in form of the MATLAB code. In the experiment, we assumed that the water level would not effect to the temperature and pressure. Conclusion: The research for the development of the fuzzy logic and the model was tested with the step inputs and the changing of the inputs. The whole simulation process was built to test the behavior of the system when the inputs change.

  13. Innovation in Bio-disaster Prevention and Control Mechanism after Forest Tenure Reform at County Level

    Institute of Scientific and Technical Information of China (English)

    ZHAN Zu-ren

    2012-01-01

    Taking Youxi County of Fujian Province as an example,the author introduced basic situations of new bio-disaster prevention and control mechanism for forest resource protection and social service works after the forest tenure reform.Then,the author analyzed new problems faced by bio-disaster prevention and control in forestry.Finally,the author present the existing problems of bio-disaster prevention and control at the county level from five aspects:innovating upon plant quarantine management mechanism;innovation upon survey methods and service modes of bio-disaster monitoring;strengthening and improving construction of bio-disaster monitoring and forecasting network;innovating upon management system for bio-disaster prevention and control;speeding up construction of service system for social prevention and control of bio-disasters.

  14. Regulatory control of high levels of carotenoid accumulation in potato tubers

    NARCIS (Netherlands)

    Zhou, X.; McQuinn, R.; Fei, Z.; Wolters, A.M.A.; Eck, van J.; Brown, C.; Giovannoni, J.J.; Li, L.

    2011-01-01

    Potato (Solanum tuberosum L.) tubers contain a wide range of carotenoid contents. To decipher the key factors controlling carotenoid levels in tubers, four potato lines (Atlantic, Désirée, 91E22 and POR03) were examined by a combination of biochemical, molecular and genomics approaches. These lines

  15. Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant

    NARCIS (Netherlands)

    Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Braatz, R.D.; Barton, P.I.

    2013-01-01

    The judicious use of buffering capacity is important in the development of future continuous pharmaceutical manufacturing processes. The potential benefits are investigated of using optimal-averaging level control for tanks that have buffering capacity for a section of a continuous pharmaceutical pi

  16. Influence of Emotion on the Control of Low-Level Force Production

    Science.gov (United States)

    Naugle, Kelly M.; Coombes, Stephen A.; Cauraugh, James H.; Janelle, Christopher M.

    2012-01-01

    The accuracy and variability of a sustained low-level force contraction (2% of maximum voluntary contraction) was measured while participants viewed unpleasant, pleasant, and neutral images during a feedback occluded force control task. Exposure to pleasant and unpleasant images led to a relative increase in force production but did not alter the…

  17. Low-level finite state control of knee joint in paraplegic standing

    NARCIS (Netherlands)

    Mulder, A.J.; Veltink, P.H.; Boom, H.B.K.; Zilvold, G.

    1992-01-01

    Low-level finite state (locked-unlocked) control is compared with open-loop stimulation of the knee extensor muscles in functional electrical stimulation (FES) induced paraplegic standing. The parameters were: duration of standing, relative torque loss in knee extensor muscles, knee angle stability,

  18. Time-Minimal Control of Dissipative Two-level Quantum Systems: the Generic Case

    CERN Document Server

    Bonnard, B; Sugny, D

    2008-01-01

    The objective of this article is to complete preliminary results concerning the time-minimal control of dissipative two-level quantum systems whose dynamics is governed by Lindblad equations. The extremal system is described by a 3D-Hamiltonian depending upon three parameters. We combine geometric techniques with numerical simulations to deduce the optimal solutions.

  19. High Prolidase Levels may be a Marker of Irreversible Extracellular Matrix Changes in Controlled Acromegaly Patients?

    Science.gov (United States)

    Tabur, S; Sezen, H; Korkmaz, H; Ozkaya, M; Akarsu, E

    2016-02-01

    The present study aimed to evaluate the activity of prolidase in controlled acromegaly patients and its association with oxidative stress. 25 acromegalic patients in remission who were followed in our outpatient clinic and 31 healthy controls were enrolled in the study. Serum growth hormone (GH), insulin-like growth factor 1 (IGF-1), total antioxidative status (TAS), total oxidative stress (TOS), total free sulfhydryl (-SH), paraoxonase (PON), arylesterase (ARE), lipid hydroperoxide (LOOH) and prolidase activity levels were measured. Percent ratio of TOS to TAS level was accepted as oxidative stress index (OSI). Serum prolidase activity, TOS, OSI, and LOOH levels were significantly higher in acromegaly patients compared to the healthy control group (pacromegaly patients compared to the healthy control group (p=0.002). Prolidase activity were positively correlated with TOS, OSI, LOOH and negatively correlated with -SH in patients with acromegaly (r=0.471, pacromegaly patients. These results suggest that extracellular matrix changes continue eventhough the disease is controlled, and elevated oxidative stress is involved in the increased prolidase activity in acromegaly patients.

  20. Bending Two-Dimensional Materials To Control Charge Localization and Fermi-Level Shift.

    Science.gov (United States)

    Yu, Liping; Ruzsinszky, Adrienn; Perdew, John P

    2016-04-13

    High-performance electronics requires the fine control of semiconductor conductivity. In atomically thin two-dimensional (2D) materials, traditional doping technique for controlling carrier concentration and carrier type may cause crystal damage and significant mobility reduction. Contact engineering for tuning carrier injection and extraction and carrier type may suffer from strong Fermi-level pinning. Here, using first-principles calculations, we predict that mechanical bending, as a unique attribute of thin 2D materials, can be used to control conductivity and Fermi-level shift. We find that bending can control the charge localization of top valence bands in both MoS2 and phosphorene nanoribbons. The donor-like in-gap edge-states of armchair MoS2 ribbon and their associated Fermi-level pinning can be removed by bending. A bending-controllable new in-gap state and accompanying direct-indirect gap transition are predicted in armchair phosphorene nanoribbon. We demonstrate that such emergent bending effects are realizable. The bending stiffness as well as the effective thickness of 2D materials are also derived from first principles. Our results are of fundamental and technological relevance and open new routes for designing functional 2D materials for applications in which flexuosity is essential.

  1. Advanced Cell-Level Control for Extending Electric Vehicle Battery Pack Lifetime

    Energy Technology Data Exchange (ETDEWEB)

    Rehman, M. Muneeb Ur; Zhang, Fan; Evzelman, Michael; Zane, Regan; Smith, Kandler; Maksimovic, Dragan

    2017-02-16

    A cell-level control approach for electric vehicle battery packs is presented that enhances traditional battery balancing goals to not only provide cell balancing but also achieve significant pack lifetime extension. These goals are achieved by applying a new life-prognostic based control algorithm that biases individual cells differently based on their state of charge, capacity and internal resistance. The proposed life control approach reduces growth in capacity mismatch typically seen in large battery packs over life while optimizing usable energy of the pack. The result is a longer lifetime of the overall pack and a more homogeneous distribution of cell capacities at the end of the first life for vehicle applications. Active cell balancing circuits and associated algorithms are used to accomplish the cell-level life extension objectives. This paper presents details of the cell-level control approach, selection and design of the active balancing system, and low-complexity state-of-charge, capacity, and series-resistance estimation algorithms. A laboratory prototype is used to demonstrate the proposed control approach. The prototype consists of twenty-one 25 Ah Panasonic lithium-Ion NMC battery cells from a commercial electric vehicle and an integrated BMS/DC-DC system that provides 750 W to the vehicle low voltage auxiliary loads.

  2. Comparison of serum levels of copper and zinc among multiple sclerosis patients and control group.

    Directory of Open Access Journals (Sweden)

    Behnaz Sedighi

    2013-12-01

    Full Text Available There have been several studies done on the role of metals in the occurrence of multiple sclerosis (MS disease, but their roles have not been confirmed yet. Because of the lack of information on this issue, this study compared the serum level of copper and zinc in MS patients with their levels in a control group.This was an analytical, cross-sectional study conducted in Kerman (a medium size city, Iran. We assessed the serum level of copper and zinc in 58 MS patients and 39 healthy individuals, who were selected from the relatives of cases and matched for age and sex.The average serum level of Copper in cases and controls were 93.7 and 88.9 ml/dl, respectively. The corresponding numbers for Zinc were 36.7 and 40.9 ml/dl, respectively. There was no significant difference between the two groups (copper: P = 0.459; zinc: P = 0.249.The groups were matched for age, sex, and family. However, we did not find a considerable difference between the level of these metals in MS patients and controls.

  3. [Study on feasible emission control level of air pollutions for cement industry ].

    Science.gov (United States)

    Ren, Chun; Jiang, Mei; Zou, Lan; Li, Xiao-qian; Wei, Yu-xia; Zhao, Guo-hua; Zhang, Guo-ning

    2014-09-01

    The revised National Emission Standard of Air Pollutions for Cement Industry has been issued, which will be effective for the new enterprises and the existing enterprises on Mar. 1st, 2014 and July 1st, 2015, respectively. In the process of revision, the key technical issues on determination of standard limits was how to determine the feasible emission control level of air pollutions. Feasible emission control requirements were put forward, according to air pollutants emission, technologies, environmental management requirements and foreign standards, etc. The main contents of the revised standard include expanding the scope of application, increasing the pollutants, improving the particulate and NO emissions control level, and increasing special emission limits applied to key areas of air pollutants. The standard will become the gripper of pollution prevention, total emission reduction, structural adjustment and optimization of the layout, and will promote scientific and technical progression for the cement industry.

  4. Control of a Uniform Step Asymmetrical 9-Level Inverter Based on Artificial Neural Network Strategy

    Directory of Open Access Journals (Sweden)

    Rachid Taleb

    2009-12-01

    Full Text Available A neural implementation of a harmonic elimination strategy for the control auniform step asymmetrical 9-level inverter is proposed and described in this paper. AMulti-Layer Perceptrons (MLP neural network is used to approximate the mappingbetween the modulation rate and the required switching angles. After learning, the neuralnetwork generates the appropriate switching angles for the inverter. This leads to a lowcomputational-cost neural controller which is therefore well suited for real-timeapplications. This neural approach is compared to the well-known Multi-Carrier Pulse-Width Modulation (MCPWM. Simulation results demonstrate the technical advantages ofthe neural implementation of the harmonic elimination strategy over the conventionalmethod for the control of an uniform step asymmetrical 9-level inverter. The approach isused to supply an asynchronous machine and results show that the neural method ensures ahighest quality torque by efficiently canceling the harmonics generated by the inverter.

  5. Simulation and controller design for an agricultural sprayer boom leveling system

    KAUST Repository

    Sun, Jian

    2011-01-01

    According to the agricultural precision requirements, the distance from sprayer nozzles to the corps should be kept between 50 cm to 70 cm. The sprayer boom also needs to be kept parallel to the field during the operation process. Thus we can guarantee the quality of the chemical droplets distribution on the crops. In this paper we introduced a sprayer boom leveling system for agricultural sprayer vehicles with electro-hydraulic auto-leveling system. The suitable hydraulic actuating cylinder and valve were selected according to the specific systemic specifications. Furthermore, a compensation controller for the electro-hydraulic system was designed based on the mathematical model. With simulations we can optimize the performance of this controller to make sure a fast leveling response to the inclined sprayer boom. © 2011 IEEE.

  6. Thermoelectric properties control due to doping level and sintering conditions for FGM thermoelectric element

    CERN Document Server

    Kajikawa, T; Shiraishi, K; Ohmori, M; Hirai, T

    1999-01-01

    Thermoelectric performance is determined with three factors, namely, Seebeck coefficient, electrical resistivity and thermal conductivity. For metal and single crystalline semiconductor, those factors have close interrelation each $9 other. However, as the sintered thermoelectric element has various levels of superstructure from macro scale and micro scale in terms of the thermoelectric mechanism, the relationship among them is more complex than that for the $9 melt- grown element, so it is suggested that the control of the temperature dependence of thermoelectric properties is possible to enhance the thermoelectric performance for wide temperature range due to FGM approach. The research $9 objective is to investigate the characteristics of the thermoelectric properties for various doping levels and hot-pressed conditions to make the thermoelectric elements for which the temperature dependence of the performance is $9 controlled due to FGM approach varying the doping levels and sintering conditions. By usage ...

  7. Relationship between static postural control and the level of functional abilities in children with cerebral palsy

    Science.gov (United States)

    Pavão, Sílvia L.; Nunes, Gabriela S.; Santos, Adriana N.; Rocha, Nelci A. C. F.

    2014-01-01

    Background: Postural control deficits can impair functional performance in children with cerebral palsy (CP) in daily living activities. Objective: To verify the relationship between standing static postural control and the functional ability level in children with CP. Method: The postural control of 10 children with CP (gross motor function levels I and II) was evaluated during static standing on a force platform for 30 seconds. The analyzed variables were the anteroposterior (AP) and mediolateral (ML) displacement of the center of pressure (CoP) and the area and velocity of the CoP oscillation. The functional abilities were evaluated using the mean Pediatric Evaluation of Disability Inventory (PEDI) scores, which evaluated self-care, mobility and social function in the domains of functional abilities and caregiver assistance. Results: Spearman's correlation test found a relationship between postural control and functional abilities. The results showed a strong negative correlation between the variables of ML displacement of CoP, the area and velocity of the CoP oscillation and the PEDI scores in the self-care and caregiver assistance domains. Additionally, a moderate negative correlation was found between the area of the CoP oscillation and the mobility scores in the caregiver assistance domain. We used a significance level of 5% (p <0.05). Conclusions: We observed that children with cerebral palsy with high CoP oscillation values had lower caregiver assistance scores for activities of daily living (ADL) and consequently higher levels of caregiver dependence. These results demonstrate the repercussions of impairments to the body structure and function in terms of the activity levels of children with CP such that postural control impairments in these children lead to higher requirements for caregiver assistance. PMID:25054383

  8. Selenium and leptin levels in febrile seizure: a case-control study in children

    Directory of Open Access Journals (Sweden)

    Abolfazl Khoshdel

    2013-02-01

    Full Text Available &lt;b&gt;Purpose&lt;/b&gt;: Febrile seizures (FS are seizures that occur between the age of 6 and 60 months, but its pathophysiology still is not fully understood. There is limited information about the correlation between levels of selenium and leptin with FS. This study aimed to determine the relationship between serum levels of selenium and leptin in children with FS. &lt;b&gt;Methods:&lt;/b&gt; This case-control study was conducted in a University Hospital in Shahrekord, Iran, in 2011. The serum levels of selenium and leptin of 25 children with simple febrile seizure (case group were compared with 25 febrile children without seizure (control group in acute phase and after three months. The levels of serum selenium and leptin were measured by flame atomic absorption spectrophotometer and enzyme-linked immunosorbent assay method, respectively. &lt;b&gt;Results&lt;/b&gt;: In acute phase, the mean serum level of selenium in case and control groups were 95.88± 42.55 and 113.25±54.43 μg/dL, respectively, and difference was not significant (&lt;i&gt;P&lt;/i&gt; =0.415, but after three months, this level had a significant increase in both groups (&lt;i&gt;P&lt;/i&gt;&lt;0.001. In acute phase, the mean serum leptin level in case and control groups were 0.94±0.5 and 0.98±0.84 ng/mL, respectively, but difference was not significant (&lt;i&gt;P&lt;/i&gt; =0.405. After three months, serum leptin level had no significant change in both groups (&lt;i&gt;P&lt;/i&gt; =0.882. &lt;b&gt;Conclusion&lt;/b&gt;: These observations suggest that serum levels of selenium and leptin have not specific relation with FS but overllay is lower, however, further study is recommended. Also selenium level in stress and acute phase was significantly lower than recovery phase.

  9. Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study.

    Science.gov (United States)

    Minatoya, Machiko; Kutomi, Goro; Shima, Hiroaki; Asakura, Sumiyo; Otokozawa, Seiko; Ohnishi, Hirofumi; Akasaka, Hiroshi; Miura, Tetsuji; Mori, Mitsuru; Hirata, Koichi

    2014-01-01

    It is known that obesity is one of the risk factors for breast cancer although the association may differ between ethnic groups and with the menopausal status. Recently obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk. We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of Japanese female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status. Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women (odds ratio (OR), 0.01; 95% confidence interval (CI), 0.00-0.26 and 0.13; 0.03-0.57, respectively). Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women (OR, 0.04; 95% CI, 0.00-0.69, OR, 0.28; 95% CI, 0.07-1.11, respectively). These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan, adding evidence for the obesity link.

  10. Indirect Field Oriented Control for Five Phase Three Level Neutral Point Clamped Inverter Fed PMSM Drive

    Directory of Open Access Journals (Sweden)

    S. Sengottaian

    2015-08-01

    Full Text Available This study deals with a five phase three level Neutral Point Clamped (NPC inverter fed PMSM drive application. The motor performances depend upon mathematical model so the parameters vary are: noise, common mode voltage, flux variation and harmonic levels of the inverter or motor. Voltage saturation is one of the major problems of a motor which occurs due to speed oscillations, more current fluctuations. This problem can be solved by using PWM technique depends on the reference motor torque and flux. In this study Indirect Field Oriented Control (IFOC NPC inverter is suggested to reduce the voltage saturation. The three level neutral point clamped inverter is widely used for medium and high level applications. Compared with standard two level inverter, this type of NPC inverters have more merits. It generates greater number of levels output waveform in lower harmonic content at the same switching frequency and less voltage stress across the semiconductor switches; finally motor performance and control schemes are verified by using MATLAB/SIMULINK.

  11. The advantages and disadvantages of centralized control of air power at operational level

    Science.gov (United States)

    Arisoy, Uǧur

    2014-05-01

    People do not want to see and hear a war. In today's world, if war is inevitable, the use of air power is seen as the preferable means of conducting operations instead of financially burdensome land battles which are more likely to cause heavy loss of life. The use of Air Power has gained importance in NATO operations in the Post-Cold War era. For example, air power has undertaken a decisive role from the beginning to the end of the operation in Libya. From this point of view, the most important issue to consider is how to direct air power more effectively at operational level. NATO's Core JFAC (Joint Force Air Command) was established in 2012 to control joint air power at operational level from a single center. US had experienced JFAC aproach in the Operation Desert Storm in 1991. UK, France, Germany, Italy and Spain are also directing their air power from their JFAC structures. Joint air power can be directed from a single center at operational level by means of JFAC. JFAC aproach provides complex planning progress of Air Power to be controled faster in a single center. An Air Power with a large number of aircrafts, long range missiles of cutting-edge technology may have difficulties in achieving results unless directed effectively. In this article, directing air power more effectively at operational level has been studied in the framework of directing air power from a single center carried out by SWOT analysis technique. "Directing Air Power at operational level from a single center similar to JFAC-like structure" is compared with "Directing Air Power at operational level from two centers similar to AC (Air Command) + CAOC (Combined Air Operations Center) structure" As a result of this study, it is assessed that directing air power at operational level from a single center would bring effectiveness to the air campaign. The study examines directing air power at operational level. Developments at political, strategic and tactical levels have been ignored.

  12. Point defect reduction in wide bandgap semiconductors by defect quasi Fermi level control

    Science.gov (United States)

    Reddy, P.; Hoffmann, M. P.; Kaess, F.; Bryan, Z.; Bryan, I.; Bobea, M.; Klump, A.; Tweedie, J.; Kirste, R.; Mita, S.; Gerhold, M.; Collazo, R.; Sitar, Z.

    2016-11-01

    A theoretical framework for a general approach to reduce point defect density in materials via control of defect quasi Fermi level (dQFL) is presented. The control of dQFL is achieved via excess minority carrier generation. General guidelines for controlling dQFL that lead to a significant reduction in compensating point defects in any doped material is proposed. The framework introduces and incorporates the effects of various factors that control the efficacy of the defect reduction process such as defect level, defect formation energy, bandgap, and excess minority carrier density. Modified formation energy diagrams are proposed, which illustrate the effect of the quasi Fermi level control on the defect formation energies. These formation energy diagrams provide powerful tools to determine the feasibility and requirements to produce the desired reduction in specified point defects. An experimental study of the effect of excess minority carriers on point defect incorporation in GaN and AlGaN shows an excellent quantitative agreement with the theoretical predictions. Illumination at energies larger than the bandgap is employed as a means to generate excess minority carriers. The case studies with CN in Si doped GaN, H and VN in Mg doped GaN and VM-2ON in Si doped Al0.65Ga0.35N revealed a significant reduction in impurities in agreement with the proposed theory. Since compensating point defects control the material performance (this is particularly challenging in wide and ultra wide bandgap materials), dQFL control is a highly promising technique with wide scope and may be utilized to improve the properties of various materials systems and performance of devices based upon them.

  13. Is There a Relationship Between 25-Hydroksyvitamin D3 Levels and Diabetes Control?

    Directory of Open Access Journals (Sweden)

    Maide Hacer Tekin

    2016-03-01

    Full Text Available Aim: The aim of this study was to evaluate the relationship between hemoglobin A1c (HbA1c and 25-hydroxyvitamin D levels and to investigate the difference in this relationship between genders. Methods: In this study, we retrospectively evaluated fasting blood glucose, HbA1c, 25-hydroxyvitamin D and parathyroid hormone levels in 3675 subjects (660 male, 3015 female. The subjects were divided into two groups according to sex and into three groups according to HbA1c levels as pre-diabetics (5.7-6.4%, diabetics (6.5-8.0% and uncontrolled diabetics (>8.1%. Individuals with an HbA1c value between 4.0% and 5.6% who had no history of diabetes mellitus constituted the control group. Results: Significantly low levels of 25-hydroxyvitamin D were detected in female uncontrolled diabetics (p<0.001. However, no difference found in males between the groups A downward trend in 25-hydroxyvitamin D levels was observed to start in prediabetes period. There was no significant difference in parathyroid hormone levels between the groups. Conclusion: In addition to HbA1c levels, 25-hydroxyvitamin D levels should be investigated and considered especially in follow-up of diabetic female patients.

  14. Subjective annoyance caused by indoor low-level and low frequency noise and control method

    Institute of Scientific and Technical Information of China (English)

    DI Guo-qing; ZHANG Bang-jun; SHANG Qi

    2005-01-01

    The influence of low-level noise has not been widely noticed. This paper discovered that low-level and low frequency noise(Aweighted equivalent level Leq < 45 dB) causes higher probability of subjective annoyance. The fuzzy mathematic principle was applied to deal with the threshold level of subjective annoyance from noise in this study; there is preferable relationship between the indoor noise and noise annoyance at low frequency noise level. Study indicated at the same centered noise level, the change of annoyance probability is mainly caused by the change of the frequency spectrum characteristic of the indoor noise. Under low noise level environment, without change of the medium-low frequency noise, the slight increase of medium-high frequency noise level with the help of noise sheltering effect can significantly reduce the noise annoyance. This discovery brings a new resolution on how to improve the environmental quality of working or living places. A noise control model is given in this study according to the acoustic analysis.

  15. Evaluation and correlation of stress scores with blood pressure, endogenous cortisol levels, and homocysteine levels in patients with central serous chorioretinopathy and comparison with age-matched controls.

    Science.gov (United States)

    Agarwal, Abhishek; Garg, Monika; Dixit, Nikhil; Godara, Rohini

    2016-11-01

    Stress had been associated with the development of central serous chorioretinopathy (CSC). The study was designed to evaluate the effect of stress on other risk factors of CSC such as serum cortisol levels, serum homocysteine levels, and blood pressure (BP) in CSC patients. To compare stress scores, serum cortisol and serum homocysteine levels, and BP of CSC patients with that of control population and to correlate stress scores of CSC patients with BP, serum cortisol levels, and serum homocysteine levels. Stress scores, serum morning and evening cortisol levels, serum homocysteine levels, systolic and diastolic BP of 54 CSC patients were measured and compared with that of 54 age- and sex-related controls using Student's t-test. Stress scores of CSC patients were correlated with systolic and diastolic BP, serum morning and evening cortisol levels and serum homocysteine levels and Pearson correlation coefficient (r) were calculated. Stress scores, serum homocysteine levels, serum morning and evening cortisol levels, and systolic and diastolic BP were all elevated in CSC patients as compared with age- and sex-related controls (P Stress scores of CSC patients were found to correlate strongly with serum homocysteine levels, serum morning and evening cortisol levels, and systolic and diastolic BP, with r values 0.82, 0.8, 0.8, 0.8, and 0.81, respectively (P Stress scores were elevated in CSC patients and were strongly correlated with serum homocysteine and cortisol levels and BP.

  16. Ecological feedbacks can reduce population-level efficacy of wildlife fertility control

    Science.gov (United States)

    Ransom, Jason I.; Powers, Jenny G.; Hobbs, N. Thompson; Baker, Dan L.

    2014-01-01

    1. Anthropogenic stress on natural systems, particularly the fragmentation of landscapes and the extirpation of predators from food webs, has intensified the need to regulate abundance of wildlife populations with management. Controlling population growth using fertility control has been considered for almost four decades, but nearly all research has focused on understanding effects of fertility control agents on individual animals. Questions about the efficacy of fertility control as a way to control populations remain largely unanswered. 2. Collateral consequences of contraception can produce unexpected changes in birth rates, survival, immigration and emigration that may reduce the effectiveness of regulating animal abundance. The magnitude and frequency of such effects vary with species-specific social and reproductive systems, as well as connectivity of populations. Developing models that incorporate static demographic parameters from populations not controlled by contraception may bias predictions of fertility control efficacy. 3. Many population-level studies demonstrate that changes in survival and immigration induced by fertility control can compensate for the reduction in births caused by contraception. The most successful cases of regulating populations using fertility control come from applications of contraceptives to small, closed populations of gregarious and easily accessed species. 4. Fertility control can result in artificial selection pressures on the population and may lead to long-term unintentional genetic consequences. The magnitude of such selection is dependent on individual heritability and behavioural traits, as well as environmental variation. 5. Synthesis and applications. Understanding species' life-history strategies, biology, behavioural ecology and ecological context is critical to developing realistic expectations of regulating populations using fertility control. Before time, effort and funding are invested in wildlife

  17. The fulfillment of two-level control in experimental optical delay line of Michelson Stellar Interferometer

    Science.gov (United States)

    Chao, Li; Wu, Zhen; Wang, Jianing; Liu, Yi; Chen, Yi

    2010-07-01

    This article is focused on the two-level control system of ODL, which are divided into bottom layer control of linear motor and upper layer control of Piezoelectric Transducer(PZT).This ODL are designed to compensate geometrical optical path difference, which results from the earth rotation, and other disturbances, with high-accuracy and real time. Based on the PLC of PMAC controller, the linear motor tracks the trajectory of the simulated optical path difference to compensate roughly. PZT then compensates the rest error measured by ZLM almost real time. A detailed fulfillment of this method is shown in the article, and the first result data is produced. The result implies that this method is efficient. This article offers the reference for the ODL development with the practical high accuracy of compensation.

  18. Sliding mode control of solid state transformer using a three-level hysteresis function

    Institute of Scientific and Technical Information of China (English)

    刘宝龙; 査亚兵; 张涛

    2016-01-01

    The solid state transformer (SST) can be viewed as an energy router in energy internet. This work presents sliding mode control (SMC) to improve dynamic state and steady state performance of a three-stage (rectifier stage, isolated stage and inverter stage) SST for energy internet. SMC with three-level hysteresis sliding functions is presented to control the input current of rectifier stage and output voltage of inverter stage to improve the robustness under external disturbance and parametric uncertainties and reduce the switching frequency. A modified feedback linearization technique using isolated stage simplified model is presented to achieve satisfactory regulation of output voltage of the isolated stage. The system is tested for steady state operation, reactive power control, dynamic load change and voltage sag simulations, respectively. The switching model of SST is implemented in Matlab/ Simulink to verify the SST control algorithms.

  19. Low-level feedback control for the phase regulation of CLIC Drive Beam Klystrons

    CERN Document Server

    AUTHOR|(SzGeCERN)752526

    2015-01-01

    The requirement of luminosity loss below 1% raises tight tolerances for the phase and power stability of the CLIC drive beam (DB) klystrons and consequently for the high voltage pulse ripple of the modulators. A low-level RF (LLRF) feedback system needs to be developed and combined with the modulator in order to guarantee the phase and amplitude tolerances. To this aim, three feedback control strategies were investigated, i) Proportional Integral (PI) controller, ii) Linear Quadratic Integral Regulator (LQI) and iii) Model Predictive Controller (MPC). The klystron, as well as the incident phase noise were modelled and used for the design and evaluation of the controllers. First simulation results are presented along with future steps and directions.

  20. Positive Association between Blood 25-Hydroxyvitamin D Levels and Pterygium after Control for Sunlight Exposure.

    Science.gov (United States)

    Jee, Donghyun; Kim, Eun Chul; Cho, Eunyoung; Arroyo, Jorge G

    2016-01-01

    To investigate the association between blood 25-hydroxyvitamin D levels and pterygium. Korean National Health and Nutrition Examination Survey 2008-2011 were used for the present epidemiologic study. A total of 19,178 participants aged ≥ 30 years were evaluated for blood 25-hydroxyvitamin D levels and performed ophthalmic slit lamp examinations. Pterygium was considered as a growth of fibrovascular tissue over the cornea. The average blood 25-hydroxyvitamin D levels were 18.6 ng/mL, and prevalence of pterygium was 6.5%. The odds of pterygium significantly increased across blood 25-hydroxyvitamin D quintiles after controlling sun exposure time as well as other confounders such as sex, age, smoking, diabetes, hypertension (P exposure time, we found a positive association between blood 25-hydroxyvitamin D levels and pterygium in a representative Korean population. The mechanism underlying this association is unknown.

  1. Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation.

    Science.gov (United States)

    de Lima, Camila Bruna; Cordeiro, Fernanda Bertuccez; Camargo, Mariana; Zylbersztejn, Daniel Suslik; Cedenho, Agnaldo Pereira; Bertolla, Ricardo Pimenta; Lo Turco, Edson Guimarães

    2017-04-01

    This observational study aimed to establishing a relationship between lipid peroxidation and endometriosis in women undergoing controlled ovarian hyperstimulation. A total of 79 women were divided into two groups: (i) controls (tubal or male factor); and (ii) endometriosis (stages III/IV). The endometriosis diagnosis was confirmed by videolaparoscopy and the controlled ovarian stimulation protocol was similar to all patients. Follicular fluid (FF) lipid peroxidation levels were determined through the quantification of malondialdehyde. Statistical analysis was performed using parametric and non-parametric tests, logistic regression was performed to estimate the chance of achieving a pregnancy in each group and a moving average was calculated for the endometriosis group. Peroxidation levels in the endometriosis group were significantly higher when compared to controls. The moving average showed a decrease of MDA levels in the endometriosis group with increasing female age. Moreover, women with endometriosis who were under 33 years of age were 4.3 times more likely to achieve a pregnancy than women above that age. In conclusion, endometriosis is associated with increased FF oxidative stress (OS) in patients undergoing in vitro fertilization (IVF). Also, increasing age is associated with a decrease in severity of the oxidative status, but a decreased chance of pregnancy.

  2. Low triglyceride levels are associated with a better metabolic control in patients with type 1 diabetes

    Directory of Open Access Journals (Sweden)

    Alcantara Leticia M

    2011-09-01

    Full Text Available Abstract Background Although it is well known in the literature that high triglyceride serum (TG levels can jeopardize the metabolic control, little is known about the influence of low TG on type 1 diabetes patients (T1D. The aim of this study is to investigate the distribution of TG serum levels in individuals with T1D and its relationship with metabolic control. Findings We reviewed the medical charts of 180 patients with T1D, who were classified in groups according to TG levels: 1 low (below 50 mg/dL; 2 normal (50-150 mg/dL; 3 high (above 150 mg/dL. TG were low in 21.1% (n = 38; group 1, normal in 68.6% (n = 123; group 2 and high in 10.6% (n = 19; group 3. High TG was associated with a poor metabolic control (p Conclusion TG lower than 50 mg/dL was common and might be associated with a better metabolic control in patients with T1D, although it is not clear whether the former is the cause or consequence for the latter.

  3. [An outpatient clinic measure and control system for anticoagulation levels, CoaguChek XS].

    Science.gov (United States)

    Romero Guardeño, Araceli; Pérez Lucena, Dolores Amalia

    2009-03-01

    A significant increase during recent years in the number of patients who need Oral Anticoagulant Treatment has meant a greater role for nurses, especially in Primary Health Care Centers, since nurses, along with doctors, are the professionals responsible for treating those patients. This control is carried out by measuring the levels of anticoagulants in the blood, regulating the anticoagulant medicine doses, and providing patients with the essential health education so patients participate in the treatment of their illness. To a large degree, the preponderance of Primary Health Care Centers in the aforementioned control has developed hand-in-hand with the availability of portable, simple and low cost coagulation measuring systems which permit a direct reading of a patient's anticoagulation level with one drop of capillary blood. The objective of this article is introduce the reader to a measuring system appropriate for outpatient clinic control of anticoagulant levels in blood by mans of the CoaguChek XS System, which is described. The authors specify the sample extraction procedure, how to measure coagulant levels, and recommendations to keep in mind while carrying out this procedure. The authors sketch the importance of health education and finally, they describe some advantages and inconveniences this system has.

  4. The investigation of usage of fluorapatite mineral (Ca{sub 5}F(PO{sub 4}){sub 3}) in tooth enamel under the different pre-irradiation thermal treatments

    Energy Technology Data Exchange (ETDEWEB)

    Toktamiş, Hüseyin, E-mail: toktamis@gantep.edu.tr [University of Gaziantep, Department of Engineering Physics, 27310 Gaziantep (Turkey); Toktamiş, Dilek; Yilmaz, S. Merve; Yazici, A. Necmeddin [University of Gaziantep, Department of Engineering Physics, 27310 Gaziantep (Turkey); Yildirim, Cihan [University of Gaziantep, Faculty of Dentistry, 27310 Gaziantep (Turkey); Özbiçki, Özlem [Dentalazer Hospital, 27310 Gaziantep (Turkey)

    2015-01-20

    Highlights: • The fluorapatite mineral extracted from tooth enamel shows TL properties. • The pre-irradiation annealing process affects the TL glow curve shape. • A huge increase was observed in maximum TL for sample annealed at 1100 °C. • Annealing about 120 min causes a huge enhancement in maximum TL peak intensity • The best reproducibility is obtained at 1000 °C of annealing temperature. - Abstract: Fluorapatite Ca{sub 5}F(PO{sub 4}){sub 3} is a kind of important thermoluminescence dosimeter (TLD) material, because the effective atomic number of fluorapatite is close to that of human bones and teeth. In the present study, thermoluminescence (TL) properties of fluorapatite mineral in tooth enamel under the different annealing temperatures with various annealing times were investigated. This study reveals that the fluorapatite in tooth enamel exhibits TL properties. Annealing of the sample affects extremely the TL glow curve and causes a huge enhancement in the sensitization of TL peak. The sample annealed at 1000 °C about 120 min gives best TL peak intensity (150 factors than un-annealed sample) and has a distinct peak around 230 °C. Also, the best reproducibility was observed for 1000 °C annealed sample temperature while un-annealed sample shows the worst reproducibility. Moreover, a good linearity in dose response is observed in the samples annealed at 400 °C and 700 °C.

  5. Control of Saturation level in the magnetic core of a welding transformer by Hysteresis Controller (HC and Proportional Integral (PI Controller

    Directory of Open Access Journals (Sweden)

    Rama Subbanna.S

    2016-12-01

    Full Text Available The objective of this paper is to analyse the performances of two controllers such as Hysteresis control (HC and proportional integral (PI control to control saturation level in the magnetic core of a welding transformer in a middle-frequency direct current (MFDC resistance spot welding system(RSWS. It consists of an input converter, welding transformer, and a full-wave rectifier mounted at the transformer secondary. The unequal ohmic resistances of the two transformer’s secondary circuits and the different characteristics of the diodes of output rectifier certainly lead to the magnetic core saturation which, consequently, causes the unwanted spikes in the transformer’s primary current and over-current protection switch-off. The goal is to analyse the performance of both controllers in terms of transients, total harmonic distortion(THD and variations in primary current and flux in the magnetic core of a welding transformer of highly nonlinear system of RSWS. The simulation study has been done in Matlab/Simulink environment and presented performance analysis. The responses shows that from the aforementioned aspects, proportional integral Controller is the better choice for controlling the saturation level in magnetic core of a welding transformer which is widely used in automobile industry welding system.

  6. Effect of dietary intervention on serum lignan levels in pregnant women - a controlled trial

    Directory of Open Access Journals (Sweden)

    Mäkelä Sari

    2010-10-01

    Full Text Available Abstract Background Mother's diet during pregnancy is important, since plant lignans and their metabolites, converted by the intestinal microflora to enterolignans, are proposed to possess multiple health benefits. Aim of our study was to investigate whether a dietary intervention affects lignan concentrations in the serum of pregnant women. Methods A controlled dietary intervention trial including 105 first-time pregnant women was conducted in three intervention and three control maternity health clinics. The intervention included individual counseling on diet and on physical activity, while the controls received conventional care. Blood samples were collected on gestation weeks 8-9 (baseline and 36-37 (end of intervention. The serum levels of the plant lignans 7-hydroxymatairesinol, secoisolariciresinol, matairesinol, lariciresinol, cyclolariciresinol, and pinoresinol, and of the enterolignans 7-hydroxyenterolactone, enterodiol, and enterolactone, were measured using a validated method. Results The baseline levels of enterolactone, enterodiol and the sum of lignans were higher in the control group, whereas at the end of the trial their levels were higher in the intervention group. The adjusted mean differences between the baseline and end of the intervention for enterolactone and the total lignan intake were 1.6 ng/ml (p = 0.018, 95% CI 1.1-2.3 and 1.4 ng/mg (p = 0.08, 95% CI 1.0-1.9 higher in the intervention group than in the controls. Further adjustment for dietary components did not change these associations. Conclusion The dietary intervention was successful in increasing the intake of lignan-rich food products, the fiber consumption and consequently the plasma levels of lignans in pregnant women. Trial registration ISRCTN21512277, http://www.isrctn.org

  7. Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study

    Directory of Open Access Journals (Sweden)

    Ersoz Galip

    2009-02-01

    Full Text Available Abstract Background Both C reactive protein (CRP and procalcitonin (PCT are well known acute phase reactant proteins. CRP was reported to increase in metabolic syndrome and type-2 diabetes. Similarly altered level of serum PCT was found in chronic liver diseases and cirrhosis. The liver is considered the main source of CRP and a source of PCT, however, the serum PCT and CRP levels in non-alcoholic fatty liver disease (NAFLD were not compared previously. Therefore we aimed to study the diagnostic and discriminative role of serum PCT and CRP in NAFLD. Methods Fifty NAFLD cases and 50 healthy controls were included to the study. Liver function tests were measured, body mass index was calculated, and insulin resistance was determined by using a homeostasis model assessment (HOMA-IR. Ultrasound evaluation was performed for each subject. Serum CRP was measured with nephalometric method. Serum PCT was measured with Kryptor based system. Results Serum PCT levels were similar in steatohepatitis (n 20 and simple steatosis (n 27 patients, and were not different than the control group (0.06 ± 0.01, 0.04 ± 0.01 versus 0.06 ± 0.01 ng/ml respectively. Serum CRP levels were significantly higher in simple steatosis, and steatohepatitis groups compared to healthy controls (7.5 ± 1.6 and 5.2 ± 2.5 versus 2.9 ± 0.5 mg/dl respectively p Conclusion Serum PCT was within normal ranges in patients with simple steatosis or steatohepatitis and has no diagnostic value. Serum CRP level was increased in NAFLD compared to controls. CRP can be used as an additional marker for diagnosis of NAFLD but it has no value in discrimination of steatohepatitis from simple steatosis.

  8. The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level.

    Science.gov (United States)

    Giraudo, A T; Cheung, A L; Nagel, R

    1997-07-01

    Agr and sar are known regulatory loci of Staphylococcus aureus that control the production of several extracellular and cell-wall-associated proteins. A pleiotropic insertional mutation in S. aureus, designated sae, that leads to the production of drastically diminished levels of alpha- and beta-hemolysins and coagulase and slightly reduced levels of protein A has been described. The study of the expression of the genes coding for these exoproteins in the sae::Tn551 mutant (carried out in this work by Northern blot analyses) revealed that the genes for alpha- and beta-hemolysins (hla and hlb) and coagulase (coa) are not transcribed and that the gene for protein A (spa) is transcribed at a somewhat reduced level. These results indicate that the sae locus regulates these exoprotein genes at the transcriptional level. Northern blot analyses also show that the sae mutation does not affect the expression of agr or sar regulatory loci. An sae::Tn551 agr::tetM double mutant has been phenotypically characterized as producing reduced or null levels of alpha-, beta-, and delta-hemolysins, coagulase, and high levels of protein A. Northern blot analyses carried out in this work with the double mutant revealed that hla, hlb, hld, and coa genes are not transcribed, while spa is transcribed at high levels. The fact that coa is not expressed in the sae agr mutant, as in the sae parental strain, while spa is expressed at the high levels characteristic of the agr parental strain, suggests that sae and agr interact in a complex way in the control of the expression of the genes of several exoproteins.

  9. Analysis of the relation between level of asthma control and depression and anxiety

    Science.gov (United States)

    Trzcińska, Hanna; Przybylski, Grzegorz; Kozłowski, Bartosz; Derdowski, Sebastian

    2012-01-01

    Summary Background Frequent co-existence of bronchial asthma and depression or anxiety is an unquestioned phenomenon. In contrast, little is known about the relationship between the degree of asthma control and the prevalence of depression and anxiety. The aim of this study was to determine the potential relationship between the degree of asthma control and the prevalence of depression and anxiety. Material/Methods This study included a group of 128 randomly selected asthmatic individuals with various degree of asthma control. The study was based on a questionnaire survey, using the following tools: the Asthma Control Test, Beck Depression Inventory, and State-Trait Anxiety Inventory (STAI) – X-1 and X-2 questionnaires. All the questionnaires were completed during a single follow-up visit at the clinic. Results The occurrence of depression and its severity significantly correlated with the degree of asthma control. Individuals with depression were characterized by a significantly lower degree of asthma control compared to depression-free individuals (p<0.001). The degree of asthma control decreased significantly with increasing severity of depression (R=−0.367; p<0.001). No significant correlation was observed between the degree of asthma control and the levels of trait anxiety (R=−0.095; p=0.295) and state anxiety (R=−0.093; p=0.308). Conclusions The prevalence of depression and its severity significantly correlate with the degree of asthma control. Large, standardized multicenter studies of the relationship between the degree of asthma control and the prevalence of depression and other psychopathological symptoms are needed. Furthermore, it seems reasonable to introduce the screening of asthmatics for mental disorders. PMID:22367130

  10. Some aspects of public associations’ participation in implementing public control at municipal level

    Directory of Open Access Journals (Sweden)

    Roman V. Gornev

    2016-03-01

    Full Text Available Objective to clarify the status of public associations as subjects of public control and to analyze the problems of participation of citizens 39 associations in conducting public expertise and public audits. Methods the methodology of research includes general scientific methods such as dialectic method. Specific jurisprudence methods of scientific cognition have also been used. Systematic method was used for the analysis of forms of public control by citizens39 associations at the municipal level. The principle of scientific objectivity has allowed for a comprehensive and objective analysis of the factual material the totality of factors affecting the interaction of public associations with local authorities in the implementation of public control. The formallegal method allowed to analyze the normativelegal acts to reveal the signs of fixing of such public control forms as public expertise and public audit. In the present study other research methods were also applied allowing to study the theme in detail. Results the study identified the lack of legal regulation of the legal status of public associations as subjects of public control as well as some forms of public control. The additions to the list of subjects of public control by public associations were proposed as well as improvements in the implementation of public expertise and public audit by the citizens39 associations as forms of social control. Scientific novelty the author found a lack of regulation of public associationsrsquo participation in some forms of social control and justified proposals for their improvement from a scientific point of view. Practical significance the possibility to apply the research results in legislative activity aimed at improving the provisions of the Federal Laws quotOn fundamentals of public control in the Russian Federationquot and quotOn the general principles of local selfgovernment organization in the Russian Federationquot. In addition the

  11. Controller Strategies for Automation Tool Use under Varying Levels of Trajectory Prediction Uncertainty

    Science.gov (United States)

    Morey, Susan; Prevot, Thomas; Mercer, Joey; Martin, Lynne; Bienert, Nancy; Cabrall, Christopher; Hunt, Sarah; Homola, Jeffrey; Kraut, Joshua

    2013-01-01

    A human-in-the-loop simulation was conducted to examine the effects of varying levels of trajectory prediction uncertainty on air traffic controller workload and performance, as well as how strategies and the use of decision support tools change in response. This paper focuses on the strategies employed by two controllers from separate teams who worked in parallel but independently under identical conditions (airspace, arrival traffic, tools) with the goal of ensuring schedule conformance and safe separation for a dense arrival flow in en route airspace. Despite differences in strategy and methods, both controllers achieved high levels of schedule conformance and safe separation. Overall, results show that trajectory uncertainties introduced by wind and aircraft performance prediction errors do not affect the controllers' ability to manage traffic. Controller strategies were fairly robust to changes in error, though strategies were affected by the amount of delay to absorb (scheduled time of arrival minus estimated time of arrival). Using the results and observations, this paper proposes an ability to dynamically customize the display of information including delay time based on observed error to better accommodate different strategies and objectives.

  12. Effects of live sax music on various physiological parameters, pain level, and mood level in cancer patients: a randomized controlled trial.

    Science.gov (United States)

    Burrai, Francesco; Micheluzzi, Valentina; Bugani, Valentina

    2014-01-01

    Few randomized controlled trial studies have focused on the effect of music in cancer patients, and there are no randomized controlled trials on the effects of live music with saxophone in cancer patients. To determine the effects of live saxophone music on various physiological parameters, pain level, and mood level. A randomized controlled trial study. 52 cancer patients were randomized to a control group (n = 26), an experimental group (n = 26) whose members received 30 minutes of live music therapy with saxophone. Systolic and diastolic blood pressure, pulse rate, glycemia, oxygen saturation, pain level, and mood level were measured before and after the live music performance. There was a statistical difference between the groups for oxygen saturation (0.003) and mood level (0.001). Live music performed with a saxophone could be introduced in oncology care to improve the oxygen saturation and mood in cancer patients.

  13. Comparison of Calcitonin Gene Related Peptide Level between Children with Dilated Cardiomyopathy and Control Group

    Directory of Open Access Journals (Sweden)

    Noormohammad Noori

    2015-06-01

    Full Text Available Background: Dilated cardiomyopathy is revealed with left ventricular dilatation and systolic dysfunction. Objectives: This study aimed to compare the children with dilated cardiomyopathy and control group regarding the level of Calcitonin Gene Related Peptide (CGRP and its relationship with echocardiography findings Patients and Methods: This case-control study was conducted on 37 children with dilated cardiomyopathy and free of any clinical symptoms and 37 healthy age- and sex-matched children referring to Ali-e-Asghar and Ali Ebne Abitaleb hospitals in Zahedan, Iran. After taking history, echocardiography was performed for both groups. The data were analyzed using the SPSS statistical software and appropriate statistical tests. Results: The two groups were significantly different regarding most of the echocardiographic parameters (P < 0.05. Also, a significant difference was found between the two groups concerning the mean CGRP levels (P = 0.001. Among echocardiographic parameters, CGRP was directly related to Interventricular Septal dimension in Systole (IVSS (P = 0.022, R = 0.375. However, no significant relationship was observed between CGRP level and Ross classification. Conclusions: The findings of this study showed an increase in CGRP serum levels in the case group. Besides, a direct correlation was observed between CGRP level and IVSS.

  14. PBDE levels in human milk: the situation in Germany and potential influencing factors - a controlled study

    Energy Technology Data Exchange (ETDEWEB)

    Vieth, B.; Mielke, H.; Ostermann, B.; Ruediger, T. [Federal Inst. for Risk Assessment, Berlin (Germany); Herrmann, T.; Paepke, O. [ERGO Forschungsgesellschaft mbH, Hamburg (Germany)

    2004-09-15

    An exponential increase of PBDE levels in breast milk from Sweden between 1972 and 1997 has been reported, which is in contrast to the continuous decline of other chlorinated POPs in breast milk. Also in blood samples from Germany, an increasing trend has been observed during the period from 1985 to 1999. The knowledge about human exposure pathways, which contribute to the PBDE body burden, is very limited. Consumption of food of animal origin, inhalation or ingestion of dust and further factors possibly influencing the PBDE levels in human matrices, like age, breast-feeding or smoking are under discussion. Only a few data on PBDE levels in breast milk from Germany have been published. To fill the data gaps, a controlled study was started in 2001 to characterise the PBDE levels in human milk from Germany with special efforts to identify and quantify deca-BDE-209. Furthermore, it was intended to verify potential factors possibly influencing PBDE levels. Two main hypotheses were proposed: (1) Are PBDE levels in breast milk from mothers consuming traditional food (omnivores) higher than those found in breast milk from mothers consuming vegetarian or vegan food? and (2) Are the PBDE levels found in human milk after a three-months period of breast-feeding lower than those detected at the beginning or does breast feeding result in a lower body burden, respectively? This paper summarises preliminary results. Further analytical data and results of data evaluation will be presented at the conference.

  15. Shuttle program. MCC level C formulation requirements: Shuttle TAEM guidance and flight control

    Science.gov (United States)

    Carman, G. L.

    1980-01-01

    The Level C requirements for the shuttle orbiter terminal area energy management (TAEM) guidance and flight control functions to be incorporated into the Mission Control Center entry profile planning processor are defined. This processor will be used for preentry evaluation of the entry through landing maneuvers, and will include a simplified three degree-of-freedom model of the body rotational dynamics that is necessary to account for the effects of attitude response on the trajectory dynamics. This simulation terminates at TAEM-autoland interface.

  16. Adaptive fuzzy control design for the molten steel level in a strip casting process

    Directory of Open Access Journals (Sweden)

    Y. J. Zhang

    2017-01-01

    Full Text Available This paper studies the adaptive fuzzy control problem of the molten steel level for a class of twin roll strip casting systems. Based on fuzzy logic systems (FLSs and the mean value theorem, a novel adaptive tracking controller with parameter updated laws is effectively designed. It is proved that all the closed-loop signals are uniformly bounded and the system tracking errors can asymptotically converge to zero by using the Lyapunov stability analysis. Simulation results of semi-experimental system dynamic model and parameters are provided to demonstrate the validity of the proposed adaptive fuzzy design approach.

  17. Hydrological forecast of maximal water level in Lepenica river basin and flood control measures

    Directory of Open Access Journals (Sweden)

    Milanović Ana

    2006-01-01

    Full Text Available Lepenica river basin territory has became axis of economic and urban development of Šumadija district. However, considering Lepenica River with its tributaries, and their disordered river regime, there is insufficient of water for water supply and irrigation, while on the other hand, this area is suffering big flood and torrent damages (especially Kragujevac basin. The paper presents flood problems in the river basin, maximum water level forecasts, and flood control measures carried out until now. Some of the potential solutions, aiming to achieve the effective flood control, are suggested as well.

  18. Grid Connected WECS with A Five Level DCMLI using PID Controller

    Directory of Open Access Journals (Sweden)

    G.Balaji

    2014-07-01

    Full Text Available This paper deals with the analysis, modeling and control system for permanent magnet synchronous generator (PMSG based wind turbine connected to the grid. A wind energy conversion using DC-DC Buck- Boost Converter for permanent magnet synchronous generator (PMSG based variable speed wind energy conversion system (WECS has been proposed which is integrated with grid using five-level diode clamped multilevel (DCMLI inverter. In this work the instantaneous values of input side current and voltage of DC-DC buck-boost converter are utilized for implementing the PID controller. The proposed work is verified by the simulation in Powersim.

  19. Coherent Phase Control of Ultrafast Polarization Beats in Reverse V-Type Three-Level System

    Institute of Scientific and Technical Information of China (English)

    LI Ling; NIE Zhi-Qiang; JIANG Tong; ZHANG Yan-Peng; LI Pei-Zhe; GAN Chen-Li; SONG Jian-Ping; LI Yuan-Yuan

    2007-01-01

    We investigate the third-order nonlinear absorption and dispersion of femto- and atto-second polarization beats between the one-photon degenerate four-wave mixing process and the two-photon nondegenerate four-wave mixing process in the pure homogeneously-broadened reverse V-three-level using twin noisy Gelds. The third-order nonlinear response can be controlled and modified by the colour-locked correlation of twin noisy fields. Most importantly, the coherent phase control in optical heterodyne detection for studying the phase dispersion of the third-order susceptibility is demonstrated. The radiation-matter detuning oscillation is also considered in the frequency domain.

  20. Acceptability of Low Level White Lighting in the Control Room at Sea

    Science.gov (United States)

    2014-08-05

    LIGHTING IN THE CONTROL ROOM AT SEA by S. M. Luria and D. A. Kobus Naval Medical Research and Development Command Research Work Unit M0100.001...release; distribution unlimited. ACCEPTABILITY OF LOW LEVEL WHITE LIGHTING " IN THE CONTROL ROOM AT SEA by S. M. Luria , Ph.D. David A. Kobus, LT...ltr 9330 Ser 51/434 to CO, NSMRL of 18 Nov 1984. 3 Luria , S. M. and David A. Kobus. The relative effectiveness of red and white light for

  1. GENERATING OF OPTIMAL QUANTIZATION LEVELS OF CONTROL CURRENTS FOR LINEAR STEPPING DRIVES OF PRECISION MOTION SYSTEMS

    Directory of Open Access Journals (Sweden)

    I. V. Dainiak

    2014-01-01

    Full Text Available The paper proposes a method of taking into account accumulated and temperature errors while forming coordinate discrete grid of a linear stepping drive. An algorithm for determination of optimal quantization levels of control currents of drive's phases has been developed in the paper; it minimizes an error of positioning that forms correction files for application of a control system in the software. Investigations on stability of discrete grid nodes coordinates have been carried our with the help of a monitoring station for accurate parameters of linear stepping drive. The investigations have proved an efficiency of the proposed algorithm and methodology for forming coordinate discrete grid.

  2. A non-IQ sampling controller in low level RF system

    Institute of Scientific and Technical Information of China (English)

    YIN Cheng-Ke; DAI Zhi-Min; LIU Jian-Fei; ZHAO Yu-Bin; ZHANG Tong-Xuan; FU Ze-Chuan; LIU Wei-Qing

    2008-01-01

    This paper describes a non-IQ controller for digital Low Level RF (LLRF) feedback control.Based on this non-IQ sarnpling method,arbitrary frequency relationship between ADC/DAC sampling clocks and IF signals can be employed.The nonlinearity in digital conversion can be reduced and the system dynamic performance improved.This paper analyzes the nonlinearity in conventional IQ sampling,gives the state variable description of the non-IQ algorithm,presents an implementation and its synchronization,and compares its performances with IQ sampling.

  3. An interleaved five-level boost converter with voltage-balance control

    DEFF Research Database (Denmark)

    Chen, Jianfei; Hou, Shiying; Deng, Fujin

    2016-01-01

    This paper proposes an interleaved five-level boost converter based on switched-capacitor network. Operating principle of the converter under CCM mode is analyzed. High voltage gain, low component stress, small input current ripple, and self-balance function for capacitor voltages in the switched......-capacitor networks are achieved. Besides, a three-loop control strategy including outer voltage loop, inner current loop and voltage-balance loop has been researched to achieve good performances and voltage-balance effect. Experimental study has been done to verify the correctness and feasibility of the proposed...... converter and control strategy....

  4. Controlling Single-Photon Transport along an Optical Waveguide by using a Three-Level Atom

    Institute of Scientific and Technical Information of China (English)

    TIAN Wei; CHEN Bin; XU Wei-Dong

    2012-01-01

    We theoretically investigate the single-photon transport properties in an optical waveguide embedded with a V-type three-level atom (VTLA) based on symmetric and asymmetric couplings between the photon and the VTLA.Our numerical results show that the transmission spectrum of the incident photon can be well controlled by virtue of both symmetric and asymmetric coupling interactions.A multifrequency photon attenuator is realized by controlling the asymmetric coupling interactions.Furthermore,the influences of dissipation of the VTLA for the realistic physical system on single-photon transport properties are also analyzed.

  5. A practical predictive control algorithm for integral processes and a case study in boiler level system

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The Dynamic Matrix Control (DMC) algorithm for integral processes is investigated in this paper. The reason why the original DMC algorithm cannot be applied to these processes is analyzed. The shifting matrix is transformed into another form and the corresponding theorem is proved, then its applicable range is extended. Compared with other algorithms on the integral processes, this algorithm is more practical and simple to implement. Simulation results also prove its validity. Applying this algorithm, we succeed in the control of the boiler level system in power units.

  6. Multi-interface Level Sensors and New Development in Monitoring and Control of Oil Separators

    Directory of Open Access Journals (Sweden)

    Wuqiang Yang

    2006-04-01

    Full Text Available In the oil industry, huge saving may be made if suitable multi-interface levelmeasurement systems are employed for effectively monitoring crude oil separators andefficient control of their operation. A number of techniques, e.g. externally mounteddisplacers, differential pressure transmitters and capacitance rod devices, have beendeveloped to measure the separation process with gas, oil, water and other components.Because of the unavailability of suitable multi-interface level measurement systems, oilseparators are currently operated by the trial-and-error approach. In this paper someconventional techniques, which have been used for level measurement in industry, and newdevelopment are discussed.

  7. Previous Creatinine Levels Safely Predict Amantadine Dose for Influenza a Outbreak Control

    Directory of Open Access Journals (Sweden)

    Jane A Buxton

    2001-01-01

    Full Text Available BACKGROUND: Amantadine, an antiviral agent, is the only drug currently approved in Canada for prophylaxis of influenza A virus infection. To minimize side effects, the amantadine dose is adjusted for age and estimated creatinine clearance (CrCl based on plasma creatinine (Cr levels. As amantadine is used more frequently for influenza A outbreak control in care facilities for elderly people, physicians are increasingly called on to prescribe it for residents and to consider the necessity of requesting plasma Cr levels.

  8. Compound control method of neutral point voltage of three level NPC inverter based on the vector method of virtual space and hysteresis control

    Science.gov (United States)

    Yang, Fengping; Xiao, Fangfei

    2017-03-01

    Current control methods include hardware control and software control corresponding to the inherent unbalance problem of neutral point voltage in three level NPC inverter. The hardware control is rarely used due to its high cost. In this paper, a new compound control method has been presented based on the vector method of virtual space and traditional hysteresis control of neutral point voltage, which can make up the shortcoming of the virtual control without the feedback control system of neutral point voltage and the blind area of hysteresis control and control the deviation and wave of neutral point voltage. The accuracy of this method has been demonstrated by simulation.

  9. Associations Between Self-Control, Practice, and Skill Level in Sport Expertise Development.

    Science.gov (United States)

    Tedesqui, Rafael A B; Young, Bradley W

    2017-03-01

    The purpose of this study was to test the association between self-control (SC) variables and (a) sport-specific practice amounts, (b) engagement in various practice contexts, (c) threats to commitment to one's sport, and (d) skill development using the Brief Self-Control Scale (BSCS) in a diverse sport sample. Two hundred forty-four athletes (47% female; Mage = 21.96 years, SD = 6.98 years; 68.8% individual sports and 31.2% team sports; 13.77 [SD = 8.12] hr/week of sport-specific practice) completed a survey composed of the BSCS and practice-related measures. Three skill groups (basic/intermediate, advanced, expert) were informed by athletes' self-reported highest level of competition. Separate analyses were conducted for juniors (aged 12-17 years) and seniors (aged 18-43 years). A 2-factor model (self-discipline and impulse control) fit the BSCS data. Fewer thoughts of quitting from one's sport were associated with higher self-discipline in juniors and seniors and were also related to higher impulse control in seniors. Greater practice amounts were associated with higher self-discipline; however, only seniors showed such associations in voluntary practice contexts. For juniors and seniors, impulse control was associated with more voluntary practicing. There were, however, no skill-group differences for levels of self-discipline or impulse control. Self-discipline and impulse control may be dispositional characteristics associated with how athletes engage in practice and avert conditions that threaten their sport commitment. SC dispositions may relate to practice amounts differently in juniors and seniors, depending on the requirements for self-regulation in a practice context.

  10. Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials?

    Directory of Open Access Journals (Sweden)

    Sierevelt Inger N

    2006-09-01

    Full Text Available Abstract Background The Levels of Evidence Rating System is widely believed to categorize studies by quality, with Level I studies representing the highest quality evidence. We aimed to determine the reporting quality of Randomised Controlled Trials (RCTs published in the most frequently cited general orthopaedic journals. Methods Two assessors identified orthopaedic journals that reported a level of evidence rating in their abstracts from January 2003 to December 2004 by searching the instructions for authors of the highest impact general orthopaedic journals. Based upon a priori eligibility criteria, two assessors hand searched all issues of the eligible journal from 2003–2004 for RCTs. The assessors extracted the demographic information and the evidence rating from each included RCT and scored the quality of reporting using the reporting quality assessment tool, which was developed by the Cochrane Bone, Joint and Muscle Trauma Group. Scores were conducted in duplicate, and we reached a consensus for any disagreements. We examined the correlation between the level of evidence rating and the Cochrane reporting quality score. Results We found that only the Journal of Bone and Joint Surgery – American Volume (JBJS-A used a level of evidence rating from 2003 to 2004. We identified 938 publications in the JBJS-A from January 2003 to December 2004. Of these publications, 32 (3.4% were RCTs that fit the inclusion criteria. The 32 RCTs included a total of 3543 patients, with sample sizes ranging from 17 to 514 patients. Despite being labelled as the highest level of evidence (Level 1 and Level II evidence, these studies had low Cochrane reporting quality scores among individual methodological safeguards. The Cochrane reporting quality scores did not differ significantly between Level I and Level II studies. Correlations varied from 0.0 to 0.2 across the 12 items of the Cochrane reporting quality assessment tool (p > 0.05. Among items closely

  11. Impact of urate level on cardiovascular risk in allopurinol treated patients. A nested case control study

    DEFF Research Database (Denmark)

    Larsen, Kasper Søltoft; Pottegård, Anton; Lindegaard, H. M.

    2015-01-01

    odds ratio for cardiovascular event between cases and controls was 1.01 (95% confidence interval 0.80 - 1.29). No significant effect was seen in any subgroup when stratifying by age, gender, renal function, allopurinol dose or the achieved urate level. Overall, the doses of allopurinol used......Background: Gout gives rise to increased risk of adverse cardiovascular outcomes. Gout attacks can be effectively prevented with urate lowering drugs such as allopurinol, and allopurinol further potentially reduces the cardiovascular risk. Whether treatment to a target level of uric acid...... is required to reduce cardiovascular risk is not known. Objectives: We sought to investigate the effect of achieving target plasma urate with allopurinol on cardiovascular outcomes in a case control study nested within long-term users of allopurinol. Methods: We identified all long-term users of allopurinol...

  12. The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila.

    Science.gov (United States)

    Lamaze, Angélique; Lamouroux, Annie; Vias, Carine; Hung, Hsiu-Cheng; Weber, Frank; Rouyer, François

    2011-06-01

    In the Drosophila circadian clock, the CLOCK/CYCLE complex activates the period and timeless genes that negatively feedback on CLOCK/CYCLE activity. The 24-h pace of this cycle depends on the stability of the clock proteins. RING-domain E3 ubiquitin ligases have been shown to destabilize PERIOD or TIMELESS. Here we identify a clock function for the circadian trip (ctrip) gene, which encodes a HECT-domain E3 ubiquitin ligase. ctrip expression in the brain is mostly restricted to clock neurons and its downregulation leads to long-period activity rhythms in constant darkness. This altered behaviour is associated with high CLOCK levels and persistence of phosphorylated PERIOD during the subjective day. The control of CLOCK protein levels does not require PERIOD. Thus, CTRIP seems to regulate the pace of the oscillator by controlling the stability of both the activator and the repressor of the feedback loop.

  13. SWATCH Common software for controlling and monitoring the upgraded CMS Level-1 trigger

    CERN Document Server

    Bologna, Simone; Dirkx, Glenn; Kreczko, Lukasz; Lazaridis, Christos; Paradas, Evangelos; Rose, A; Thea, Alessandro; Williams, Thomas Stephen

    2016-01-01

    The Large Hadron Collider at CERN restarted in 2015 with a higher centre-of-mass energy of 13TeV. The instantaneous luminosity is expected to increase significantly in the coming years. An upgraded Level-1 trigger system has been deployed in the Compact Muon Solenoid experiment, in order to maintain the same efficiencies for searches and precision measurements as those achieved in the previous run. This system consists of the order of 100 electronics boards connected by the order of 3000 optical links, which must be controlled and monitoring coherently through software, with high operational efficiency. In this paper, we present the design of the software framework that is used to control and monitor the upgraded Level-1 trigger system, and experiences from using this software to commission the upgraded system.

  14. The Effect of Glycemic Control on Plasma Ghrelin and Serum IGF-1 Levels in Type 1 Diabetic Girls

    Directory of Open Access Journals (Sweden)

    Tolga Altuğ Şen

    2009-12-01

    Full Text Available Introduction: The aim of this study was to investigate the effect of glycemic control on plasma ghrelin levels and serum IGF-1 levels in girls with type 1 diabetes. Materials and Method: The study group composed of 32 diabetic girls between the ages of 14.0-20.0 years with Tanner pubertal stage 5; and 15 healthy girls in similar ages with Tanner pubertal stage 5 formed the control group. Diabetic girls were classified as well glycemic controlled (n=18 and poor glycemic controlled (n=14 according to last year’s mean glycosylated hemoglobin levels. All subjects were tested for fasting plasma ghrelin and serum IGF-1 levels. Results: The mean fasting plasma ghrelin levels in girls with well controlled diabetes, in girls wtih poor controlled diabetes and in control group were 483.4±221.9 pg/ml, 310.7±110.2 pg/ml, 471.9±175.0 pg/ml respectively. The mean serum IGF-1 levels in girls with well controlled diabetes was 233.9±59.2 ng/ml, in girls with poor controlled diabetes 183.9±36.7 ng/ml, and in healthy controls 247.3±48.5 ng/ml. Plasma ghrelin levels and serum IGF-1 levels were similar in girls with well controlled diabetes and in the control group, however it was significantly supressed in those with poorly controlled diabetes. Conclusion: The metabolic control may be a determinative factor on plasma ghrelin and serum IGF-1 levels of type 1 diabetics. Plasma ghrelin and serum IGF-1 levels were similar in well glycemic controlled diabetics and control group, while they were suppressed in only poor glycemic controlled diabetics. (Journal of Current Pediatrics 2009; 7: 104-10

  15. Improving Parental Stress Levels Among Mothers Living with HIV: A Randomized Control Group Intervention Study

    OpenAIRE

    Johnson, Erica R.; Davies, Susan L.; Aban, Inmaculada; Mugavero, Michael J.; Shrestha, Sadeep; Kempf, Mirjam-Colette

    2015-01-01

    Limited knowledge exists regarding parenting efficacy interventions for mothers living with HIV (MLH). This study evaluated the impact of a supportive group intervention on lowering parenting stress among MLH. Eighty MLH were randomized to a parenting (N=34) or health focused (control) (N=46) group intervention. Pre- and post-intervention stress levels were assessed using the Parental Stress Index-Short Form (PSI/SF). Differences in PSI/SF scores were examined using ANOVA, and predictors of P...

  16. Low Vitamin D Levels Do Not Predict Hyperglycemia in Elderly Endurance Athletes (but in Controls.

    Directory of Open Access Journals (Sweden)

    Helmuth Haslacher

    Full Text Available Recent studies revealed a link between hypovitaminosis D3 and the risk for hyperglycemia. Further mechanistic and interventional investigations suggested a common reason for both conditions rather than a causal relationship. Exposure to sunlight is the most relevant source of vitamin D3 (25(OHD, whereas adipose tissue is able to store relevant amounts of the lipophilic vitamin. Since running/bicycling leads to increased out-door time and alters physiological response mechanisms, it can be hypothesized that the correlation between hypovitaminosis D3 and hyperglycemia might be disturbed in outdoor athletes.47 elderly marathoners/bicyclists and 47 age/sex matched controls were studied in a longitudinal setting at baseline and after three years. HbA1c as a surrogate for (pre-diabetic states was quantified via HPLC, 25(OHD levels were measured by means of chemiluminescent assays. Physical performance was assessed by ergometry.When adjusted for seasonal variations, 25(OHD was significantly higher in athletes than in controls. 25(OHD levels inversely correlated with triglycerides in both groups, whereas only in controls an association between high BMI or low physical performance with hypovitaminosis D3 had been found. Likewise, the presence of hypovitaminosis D3 at baseline successfully predicted hyperglycemia at the follow up examinations within the control group (AUC = 0.85, 95% CI [0.74, 0.96], p < .001, statistically independent from BMI, but not in athletes.Our data suggest that mechanisms of HbA1c elevation might differ between athletes and controls. Thus, intense physical activity must be taken into account as a potential pre-analytic confounder when it is aimed to predict metabolic risk by vitamin D3 levels.

  17. Control of Grid Connected Photovoltaic System Using Three-Level T-Type Inverter

    Science.gov (United States)

    Zorig, Abdelmalik; Belkeiri, Mohammed; Barkat, Said; Rabhi, Abdelhamid

    2016-08-01

    Three-level T-Type inverter (3LT2I) topology has numerous advantageous compared to three-level neutral-point-clamped (NPC) inverter. The main benefits of 3LT2I inverter are the efficiency, inverter cost, switching losses, and the quality of output voltage waveforms. In this paper, a photovoltaic distributed generation system based on dual-stage topology of DC-DC boost converter and 3LT2I is introduced. To that end, a decoupling control strategy of 3LT2I is proposed to control the current injected into the grid, reactive power compensation, and DC-link voltage. The resulting system is able to extract the maximum power from photovoltaic generator, to achieve sinusoidal grid currents, and to ensure reactive power compensation. The voltage-balancing control of two split DC capacitors of the 3LT2I is achieved using three-level space vector modulation with balancing strategy based on the effective use of the redundant switching states of the inverter voltage vectors. The proposed system performance is investigated at different operating conditions.

  18. Stability of Hand Force Production: I. Hand Level Control Variables and Multi-Finger Synergies.

    Science.gov (United States)

    Reschechtko, Sasha; Latash, Mark L

    2017-09-13

    We combined the theory of neural control of movement with referent coordinates and the uncontrolled manifold hypothesis to explore synergies stabilizing the hand action in accurate four-finger pressing tasks. In particular, we tested a hypothesis on two classes of synergies - those among the four fingers and those within a pair of control variables - stabilizing hand action under visual feedback and disappearing without visual feedback. Subjects performed four-finger total force and moment production tasks under visual feedback; the feedback was later partially or completely removed. The "inverse piano" device was used to lift and lower the fingers smoothly at the beginning and at the end of each trial. These data were used to compute pairs of hypothetical control variables. Inter-trial analysis of variance within the finger force space was used to quantify multi-finger synergies stabilizing both force and moment. A data permutation method was used to quantify synergies among control variables. Under visual feedback, synergies in the spaces of finger forces and hypothetical control variables were found to stabilize total force. Without visual feedback, the subjects showed a force drift to lower magnitudes and a moment drift toward pronation. This was accompanied by disappearance of the four-finger synergies and strong attenuation of the control-variable synergies. The indices of the two types of synergies correlated with each other. The findings are interpreted within the scheme with multiple levels of abundant variables. Copyright © 2017, Journal of Neurophysiology.

  19. Oral midazolam reduces cortisol levels during local anaesthesia in children: a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Heloisa Sousa GOMES

    2015-01-01

    Full Text Available Little is known about whether midazolam sedation can reduce salivary cortisol levels and consequently influence children’s behaviour during dental treatment. The aim of this study was to evaluate the effect of midazolam sedation on salivary cortisol and its correlation with children’s behaviour during restorative dental treatment. Eighteen healthy children, aged two to five years, were randomly assigned to two dental treatment appointments, both with physical restraint: oral midazolam 1 mg/kg (MS and placebo (PS. An observer assessed the children’s behaviour (videos using the Ohio State University Behavioral Rating Scale (OSUBRS. The children’s saliva was collected just after waking up, on arrival at the dental school, 25 minutes after local anaesthesia, and 25 minutes after the end of the procedure. Salivary cortisol levels were determined using the enzyme-linked immunoabsorbent assay. The data were analysed by bivariate tests and multivariate analysis of variance (5% level. Salivary cortisol levels were lower in the MS group than in the PS group at the time of anaesthesia (p = 0.004, but did not vary during the appointment within sedation (p = 0.319 or placebo (p = 0.080 groups. Children’s behaviour was negative most of the time and did not differ between MS and PS; however, the behaviour (OSUBRS did not correlate with salivary cortisol levels. Oral midazolam is able to control salivary cortisol levels during dental treatment of pre-schoolers, which might not lead to better clinical behaviour.

  20. SEVEN LEVEL CONTROL OF SHUNT ACTIVE POWER FILTER FOR POWER QUALITY ENHANCEMENT

    Directory of Open Access Journals (Sweden)

    G. JAYAKRISHNA

    2011-09-01

    Full Text Available Shunt Active Power Filter (SAPF is one of the controllers to enhance power quality (PQ. This paper presents Hybrid Cascaded Seven-Level Inverter (HCSLI used in SAPF to compensate reactive power, improve the power factor and to suppress the total harmonic distortion (THD in supply current due to linear load and Non- Linear Diode Rectifier Loads (NLDRLs.In this paper d-q reference frame theory for reference current computation, Constant Switching Frequency Multicarrier Sub-Harmonic Pulse Width Modulation (CSFMSHPWM technique for controlling the switches of HCSLI, Fuzzy logic controller (FLC for regulating dc side capacitor voltage are proposed. The results are validated through simulation using Mat Lab/simulink with and without SAPF for linear and nonlinear loads.

  1. Maintenance Free and Sustainable High-Level Control in Cement and Mining Industry

    DEFF Research Database (Denmark)

    Hansen, Ole Fink

    2009-01-01

    High-level control systems have been utilized in the process industry for decades, and also in cement production their use is well established. In comparison to manual control their ability to increase production and quality of end product, while reducing energy consumption and emission, is well...... that navigating the source code, understanding the interaction of signals and tracking down the statement in the code responsible for the problem is the issues which require expert knowledge and they are very time consuming. In contrast, it is relatively simple to conduct the actual modification once the few...... to be logged is compatible with the storage capacity of current computers. Preliminary statistical analysis of the logged data shows that normal and abnormal behavior of a real-world control algorithm can be distinguished so an alarm can be raised. The method enables backtracking of signal dependencies...

  2. When ecosystem services interact: crop pollination benefits depend on the level of pest control

    Science.gov (United States)

    Lundin, Ola; Smith, Henrik G.; Rundlöf, Maj; Bommarco, Riccardo

    2013-01-01

    Pollination is a key ecosystem service which most often has been studied in isolation although effects of pollination on seed set might depend on, and interact with, other services important for crop production. We tested three competing hypotheses on how insect pollination and pest control might jointly affect seed set: independent, compensatory or synergistic effects. For this, we performed a cage experiment with two levels of insect pollination and simulated pest control in red clover (Trifolium pratense L.) grown for seed. There was a synergistic interaction between the two services: the gain in seed set obtained when simultaneously increasing pollination and pest control outweighed the sum of seed set gains obtained when increasing each service separately. This study shows that interactions can alter the benefits obtained from service-providing organisms, and this needs to be considered to properly manage multiple ecosystem services. PMID:23269852

  3. A Novel Neutral Point Voltage Control Strategy for Three-Level NPC APF Based on SVPWM

    Directory of Open Access Journals (Sweden)

    Yao Xiaolong

    2015-01-01

    Full Text Available The unbalance of the neutral point voltage is an inherent problem of three-level neutral-point-clamped (NPC Active Power Filter (APF; this paper analyzes the causes of unbalanced neutral point voltage and studies the reason of the unbalance of the neutral point voltage. A novel neutral point voltage control strategy using Space Vector Pulse Width Modulation (SVPWM is proposed. The proposed strategy is based on the traditional SVPWM, by controlling the effect time of small vector, which can change the state of the midpoint voltage fluctuation, and the neutral point voltage can be maintained balance. The influence of the vector on neutral point balance is investigated in depth. Simulation results show the neutral point voltage balancing control strategy based on SPWM is effective.

  4. Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels

    Science.gov (United States)

    Delorme-Walker, Violaine; Seo, Ji-Yeon; Gohla, Antje; Fowler, Bruce; Bohl, Ben; DerMardirossian, Céline

    2015-01-01

    Cofilin, a critical player of actin dynamics, is spatially and temporally regulated to control the direction and force of membrane extension required for cell locomotion. In carcinoma cells, although the signaling pathways regulating cofilin activity to control cell direction have been established, the molecular machinery required to generate the force of the protrusion remains unclear. We show that the cofilin phosphatase chronophin (CIN) spatiotemporally regulates cofilin activity at the cell edge to generate persistent membrane extension. We show that CIN translocates to the leading edge in a PI3-kinase–, Rac1-, and cofilin-dependent manner after EGF stimulation to activate cofilin, promotes actin free barbed end formation, accelerates actin turnover, and enhances membrane protrusion. In addition, we establish that CIN is crucial for the balance of protrusion/retraction events during cell migration. Thus, CIN coordinates the leading edge dynamics by controlling active cofilin levels to promote MTLn3 cell protrusion. PMID:26324884

  5. Low-Level RF Control of Spallation Neutron Source: System and Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Hengjie [ORNL

    2005-01-01

    The low-level RF control system currently commissioned throughout the Spallation Neutron Source (SNS) LINAC evolved from three design iterations over one year intensive research and development. Its digital hardware implementation is efficient, and has succeeded in achieving a minimum latency of less than 150 ns which is the key for accomplishing an all digital feedback control for the full bandwidth. The control bandwidth is analyzed in frequency domain and characterized by testing its transient response. The hardware implementation also includes the provision of a time-shared input channel for a superior phase differential measurement between the cavity field and the reference. A companion co-simulation system for the digital hardware was developed to ensure a reliable long-term supportability. A large effort has also been made in the operation software development for the practical issues such as the process automations, cavity filling, beam loading compensation, and the cavity mechanical resonance suppression.

  6. Evaluating the Level of Internal Control System in the Management of Financial Security of Bank

    Directory of Open Access Journals (Sweden)

    Pidvysotska Lyudmyla J.

    2017-06-01

    Full Text Available The article is aimed at studying the organization and technology of evaluation process of the internal control system of bank in order to ensure financial security management of its activities. The work of the internal audit service on monitoring and evaluating the performance of the bank’s internal control system was analyzed. It has been found that improving the level of financial security of commercial banks is conditional upon improvements in the quality of audits and the provision of sound and objective conclusions. The interrelation of the tasks of internal audit service and the tasks of bank’s financial security management has been determined. Methodological recommendations on evaluation of the bank’s internal control system on the basis of results of audit have been proposed.

  7. Cost-Effective Control of Ground-Level Ozone Pollution in and around Beijing

    Institute of Scientific and Technical Information of China (English)

    Xie Xuxuan; Zhang Shiqiu; Xu Jianhua; Wu Dan; Zhu Tong

    2012-01-01

    Ground level ozone pollution has become a significant air pollution problem in Beijing. Because of the complex way in which ozone is formed, it is difficult for policy makers to identify optimal control options on a cost-effective basis. This paper identi- fies and assesses a range of options for addressing this problem. We apply the Ambient Least Cost Model and compare the eco- nomic costs of control options, then recommend the most effective sequence to realize pollution control at the lowest cost. The study finds that installing of Stage II gasoline vapor recovery system at Beijing's 1446 gasoline stations would be the most cost-effective option. Overall, options to reduce ozone pollution by cutting ve- hicular emissions are much more cost-effective than options to "clean up" coal-fired power plants.

  8. SWATCH Common software for controlling and monitoring the upgraded CMS Level-1 trigger

    CERN Document Server

    Lazaridis, Christos

    2017-01-01

    The Large Hadron Collider at CERN restarted in 2015 with a higher centre-of-mass energy of 13 TeV. The instantaneous luminosity is expected to increase significantly in the coming years. An upgraded Level-1 trigger system is being deployed in the CMS experiment in order to maintain the same efficiencies for searches and precision measurements as those achieved in the previous run. This system must be controlled and monitored coherently through software, with high operational efficiency.The legacy system is composed of approximately 4000 data processor boards, of several custom application-specific designs. These boards are organised into several subsystems; each subsystem receives data from different detector systems (calorimeters, barrel/endcap muon detectors), or with differing granularity. These boards have been controlled and monitored by a medium-sized distributed system of over 40 computers and 200 processes. Only a small fraction of the control and monitoring software was common between the different s...

  9. Postural control and fear of falling in persons with low-level paraplegia

    Directory of Open Access Journals (Sweden)

    Ligie T. John, BPT

    2010-07-01

    Full Text Available Falls are prevalent reasons for spinal cord injury (SCI. Postinjury fear of falling (FOF can affect rehabilitation potential. We quantified FOF in 15 men with paraplegia (ambulatory with bilateral knee-ankle-foot orthoses [KAFOs] and elbow crutches in correlation with their postural control at the center for long-term SCI rehabilitation of a tertiary-care teaching hospital. Our outcome measures comprised the American Spinal Injury Association Impairment Scale, the Modified Falls Efficacy Scale (MFES, postural sway measurements in the anteroposterior and mediolateral directions; and walking speed, cadence, and endurance. We assessed FOF with the MFES followed by measuring postural sway with a force platform. We measured gait parameters by asking the participant to ambulate on an indoor pathway. The mean postural sway was 314.13 +/- 184.05 mm (mean +/- standard deviation in the anteroposterior direction and 222.16 +/- 112.34 mm in the mediolateral direction. The MFES score was 41.29 +/- 12.77, which showed a statistically significant negative correlation with postural control. The self-perception of confidence as measured by MFES might not really represent the actual postural stability in individuals with low-level paraplegia. FOF can adversely affect the postural control of individuals with low-level paraplegia. Clinicians should consider FOF as an influential factor in postural control during rehabilitation.

  10. The centering and leveling adjustment and control technology for the ultra-precision turntable

    Science.gov (United States)

    Tian, Yanrong; Wang, Yun; Wang, Longxiao; Zhao, Weirui

    2015-08-01

    In order to realize the centering and leveling adjustment in large aperture spherical and aspheric surface shape measurement, by combining with the aerostatic bearing rotary shaft, working platform, high performance servo motor, photoelectric encoder, the micro displacement actuator of XYZ axis, sensor and Renishaw circular grating ,a set of fast and ultra-precision centering and leveling adjustment system is developed .The system is based on large range of air lubrication technology for high precision aerostatic bearing turntable, using the principle of three point supporting method, and the driving of tens nanometer resolution are provided by a piezoelectric micro displacement actuator. To realize the automatical centering and leveling adjustment in the large aperture spherical and aspheric surface shape measurement system, a software control program is designed with VC++. Through experimental test: centering adjusting operation can eventually converges to 0.5μm, leveling adjusting operation can eventually converges to 0.2 ", the time of adjusting can be less than 120 s. The experimental results shows that, compared with the previous system, the structure of the developed measurement and control system is more simple, more flexible, it can meet the demands of high precision, high resolution, large adjusting range, no friction, easy to drive, and high bearing stiffness etc in eccentric adjusting operation of optical precision measurement well.

  11. Control and design of full-bridge three-level converter for renewable energy sources

    DEFF Research Database (Denmark)

    Yao, Zhilei; Xu, Jing; Guerrero, Josep M.

    2015-01-01

    Output voltage of renewable energy sources, such as fuel cell and PV cell, is often low and varies widely with load and environmental conditions. Therefore, the high step-up DC-DC converter is needed between renewable energy sources and the grid-connected inverter. However, voltage stress...... of rectifier diodes is high and filter is large in traditional voltage-source converters in a wide input-voltage range. In order to solve the aforementioned problems, a full-bridge (FB) three-level (TL) converter is proposed. It can operate at both two-level and three-level modes, so it is suitable for wide...... input-voltage range application. Compared with FB converter, voltage stress of rectifier diodes and the filter can be reduced. Operating principle and control strategy of the proposed converter are illustrated. Design guidelines and example are given. Simulation results of a 1-kW FB TL converter verify...

  12. Comparison of vitamin D level in children with type 1 diabetes versus control

    Directory of Open Access Journals (Sweden)

    Zahra Alian

    2015-10-01

    Full Text Available Background: The most action of vitamin D in body is bone mineral homeostasis.Thereare reports that vitamin D deficiency increases the incidence of type 1diabetes. Aim: to investigate the frequency of vitamin D deficiency in children with type 1 diabetes. Methods and Material: In this prospective cross sectional study 62 patients with type 1 diabetes and 90 healthy individuals were studied. At the first visit, height, weight, blood pressure and sexual maturation then 25OHD, P, Ca, ALKP in both and HbA1c levels in diabetic patients is assessed. Results: In diabetic patients93/6% (n=58 had inadequate and6.5 % (n=4 had adequate level of vitamin D. In the control group, 64/4% (n=58 inadequate and 35.6% (n=32 had adequate levels of vitamin D. Conclusion: This study shows with use of vitamin D in children with vitamin D deficiency prevents of Diabetes in future.

  13. EPICS based low-level radio frequency control system in LIPAc

    Energy Technology Data Exchange (ETDEWEB)

    Calvo, Julio, E-mail: julio.calvo@ciemat.es [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Ciemat (Spain); Rivers, Mark L. [Department of Geophysical Sciences and Center for Advanced Radiation Sources, The University of Chicago (United States); Patricio, Miguel A. [Departamento de Informatica, Universidad Carlos III de Madrid (Spain); Ibarra, Angel [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Ciemat (Spain)

    2012-11-15

    Highlights: Black-Right-Pointing-Pointer The system proposed can control amplitude and phase of each cavity. Black-Right-Pointing-Pointer Rapid diagnostics are refreshed in milliseconds. Black-Right-Pointing-Pointer Increasing control parameters will not increase consumed time neither complexity. Black-Right-Pointing-Pointer IQ demodulation can be achieved thanks to the transformed values at driver level. - Abstract: The IFMIF-EVEDA (International Fusion Materials Irradiation Facility - Engineering Validation and Engineering Design Activity) linear accelerator, known as Linear IFMIF Prototype Accelerator (LIPAc), will be a 9 MeV, 125 mA continuous wave (CW) deuteron accelerator prototype to validate the technical options of the accelerator design for IFMIF. The primary mission of such facility is to test and verify materials performance when subjected to extensive neutron irradiation of the type encountered in a fusion reactor to prepare for the design, construction, licensing and safe operation of a fusion demonstration reactor (DEMO). The radio frequency (RF) power system of IFMIF-EVEDA consists of 18 RF chains working at 175 MHz with three amplification stages each. The low-level radio frequency (LLRF) controls the amplitude and phase of the signal to be synchronized with the beam and it also controls the resonance frequency of the cavities. The system is based on a commercial compact peripheral component interconnect (cPCI) field programmable gate array (FPGA) board, provided by Lyrtech and controlled by a Windows host PC. For this purpose, it is mandatory to communicate the cPCI FPGA board from EPICS Channel Access [1]. A software architecture on EPICS framework in order to control and monitor the LLRF system is presented.

  14. Caribbean mangroves adjust to rising sea level through biotic controls on change in soil elevation

    Science.gov (United States)

    McKee, K.L.; Cahoon, D.R.; Feller, Ilka C.

    2007-01-01

    Aim The long-term stability of coastal ecosystems such as mangroves and salt marshes depends upon the maintenance of soil elevations within the intertidal habitat as sea level changes. We examined the rates and processes of peat formation by mangroves of the Caribbean Region to better understand biological controls on habitat stability. Location Mangrove-dominated islands on the Caribbean coasts of Belize, Honduras and Panama were selected as study sites. Methods Biological processes controlling mangrove peat formation were manipulated (in Belize) by the addition of nutrients (nitrogen or phosphorus) to Rhizophora mangle (red mangrove), and the effects on the dynamics of soil elevation were determined over a 3-year period using rod surface elevation tables (RSET) and marker horizons. Peat composition and geological accretion rates were determined at all sites using radiocarbon-dated cores. Results The addition of nutrients to mangroves caused significant changes in rates of mangrove root accumulation, which influenced both the rate and direction of change in elevation. Areas with low root input lost elevation and those with high rates gained elevation. These findings were consistent with peat analyses at multiple Caribbean sites showing that deposits (up to 10 m in depth) were composed primarily of mangrove root matter. Comparison of radiocarbon-dated cores at the study sites with a sea-level curve for the western Atlantic indicated a tight coupling between peat building in Caribbean mangroves and sea-level rise over the Holocene. Main conclusions Mangroves common to the Caribbean region have adjusted to changing sea level mainly through subsurface accumulation of refractory mangrove roots. Without root and other organic inputs, submergence of these tidal forests is inevitable due to peat decomposition, physical compaction and eustatic sea-level rise. These findings have relevance for predicting the effects of sea-level rise and biophysical processes on tropical

  15. The level of emotion control, anxiety, and self-efficacy in the elderly in Bialystok, Poland.

    Science.gov (United States)

    Cybulski, Mateusz; Cybulski, Lukasz; Krajewska-Kulak, Elzbieta; Cwalina, Urszula

    2017-01-01

    The aim of the study was to assess the level of emotion control, anxiety, and self-efficacy in the inhabitants of Bialystok (Poland) aged above 60. The study included 300 people above the age of 60, inhabitants of Bialystok and its neighborhoods: 100 residents of public nursing home, 100 participants of the University of the Third Age in Bialystok, and 100 students of the University of Healthy Senior. The three standardized psychometric scales were used in the study: Courtauld Emotional Control Scale (CECS), State-Trait Anxiety Inventory (STAI), and General Self-Efficacy Scale (GSES). The median of the overall score of CECS equaled 54 points, which is considered average in terms of negative emotions acceptance. The mean score of perceiving anxiety as the condition of STAI (X1) was 48 points, while anxiety as a trait of STAI (X2) was 49 points. The overall score for GSES proved that respondents had a subjective feeling of self-efficacy at the level of 29 points out of 40 points possible, which means that their self-efficacy was rather at the high level in their self-assessment. In women, a negative correlation was revealed between the sense of self-efficacy and age (r=-0.320, P<0.001). Analyzing the study group affiliation of respondents, a negative correlation was reported between the sense of self-efficacy and age among the elderly residents of public nursing home (r=-0.408, P<0.001). Taking into consideration the study group affiliation of respondents, a positive correlation between anger control (CECS) and the sense of anxiety as a trait of STAI (X2) was found among participants of the University of Healthy Senior (r=0.307, P=0.002). The social and demographic features (gender, group affiliation, age) analyzed in the study were found to be correlated significantly with the control of negative emotions, the level of anxiety, and self-efficacy. The study group affiliation was a key variable conditioning the relations between the analyzed features. The elderly

  16. Levels of automation and user control - evaluation of a turbine automation interface

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Jonas (Chalmers Univ. of Technology (Sweden))

    2008-10-15

    The study was performed during the annual operator training at the Studsvik nuclear power plant simulator facility in Nykoeping, Sweden. The participating operators came from the Oskarshamn 3 nuclear power plant. In the study, seven nuclear power plant turbine operators were interviewed concerning their use of the automatic turbine system. A field study approach together with a heuristic usability evaluation was made to assess how the operators are affected by use of automation in the control room setting. The purpose of the study was to examine how operator performance is affected by varying levels of automation in nuclear power plant turbine operation. The Automatic Turbine System (ATS) was evaluated to clarify how the ATS interface design supports the operators work. The results show that during manual control the operators experience loss of speed and accuracy in performing actions together with difficulty of dividing attention between performing a task and overall monitoring, as the major problems. The positive aspects of manual operations lie in increased feeling of being in control when performing actions by hand. With higher levels of automation the problems shift to issues concerning difficulty of following the automatic sequences and loosing track in procedures. As the level of automation gets higher, the need of feedback increases which means that information presentation also becomes more important. The use of the semiautomatic, step-mode is often preferred by the operators since it combines the speed and accuracy of the automation with the ability of maintaining the feeling of being in control. Further, a number of usability related concerns was found in the ATS interface. The operators especially experience the presentation of the conditions that manage the automatic sequences as difficult to perceive. (author)

  17. Assessment of Serum Enzymatic Antioxidant Levels in Patients with Recurrent Aphthous Stomatitis: A Case Control Study

    Directory of Open Access Journals (Sweden)

    Ishita Gupta

    2014-01-01

    Full Text Available Background and Aim. Recurrent aphthous stomatitis (RAS is a common oral mucosal disorder characterized by recurrent, painful oral aphthae. Despite extensive research, the exact etiology of RAS remains elusive. Recently oxidant-antioxidant imbalance of the body has been implicated in the pathogenesis of recurrent aphthous stomatitis. Thus, the aim of the study was to evaluate the enzymatic antioxidant levels in patients with recurrent aphthous stomatitis. Materials and Methods. The serum levels of superoxide dismutase (SOD, glutathione peroxidase (GPx, and catalase (CAT were measured in 30 patients with recurrent aphthous stomatitis and compared to the control group, which included 30 healthy subjects. Student’s t-test was performed for statistical evaluation. Results. The mean levels of superoxide dismutase (130.2 ± 15.94 U/mL and glutathione peroxidase (3527.93 ± 488.32 U/L were found to be significantly lower in study group as compared to control group (211.9 ± 20.93 U/mL, 8860.93 ± 1105.31 U/L, resp. (P=0.000 while level of catalase in study group was significantly higher when compared to control group (10981.00 ± 1018.07 U/mL versus 9764.00 ± 1621.19 U/mL (P=0.000. Conclusion. Enzymatic antioxidant system is impaired in recurrent aphthous stomatitis patients and seems to play a crucial role in its pathogenesis.

  18. Economic-mathematical model of two-level minimax program control of economic security of a region

    Directory of Open Access Journals (Sweden)

    Andrey Fyodorovich Shorikov

    2014-09-01

    Full Text Available This article discusses a discrete-time dynamical system consisting of a set of a controllable objects (region and forming it municipalities. The dynamics each of these is described by the corresponding vector linear discrete-time recurrent relations, and its control system consist from two levels: basic (control level I that is dominating and subordinate level (control level II. Both levels have different criterions of functioning and united a priori by determined informational and control connections defined in advance. Considered addresses the problem of optimization of management of economic security of the region in the presence of risks. For the investigated problem is proposed in this work an economic-mathematical model of two-level hierarchical minimax program control of economic security of the region in the presence of risk and the general scheme of the solution.

  19. Thermal performance of a controlled cooling system for low-level optical signals

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, M.M.P.; Arguelles, E.B.; Rodriguez, J.C.C.; Garcia, M.A.P. [Universidad de Oviedo, Asturias (Spain). Dpto. de Energia

    2004-10-01

    Low-level light signals that are highly dependent on temperature are very common in measurement applications that employ sensors coupled to optical fibres. In order to amplify and condition the signal, photomultipliers are traditionally used together with climatic chambers in which the ambient temperature of the chamber is controlled. The present paper proposes the use of an avalanche photodiode (due to its lower price and size) to amplify the signal. However, this change implies more careful temperature control. This is why we propose to control the temperature in the photodiode itself and to use a thermoelectric cooler. This system design suggests the convenience of the development of a thermal study that is presented here. The electrical intensity of the thermoelectric cooler, the influence of the surrounding temperature and the use of isolating material or air in the space between the photodiode and the walls of the chamber are analysed. Computational fluid dynamic (CFD) techniques were applied to model the system and the model was satisfactorily validated. The feasibility of carrying out the temperature control in the cold junction of the thermoelectric cooler instead of in the photodiode itself was tested and was found to improve control. (author)

  20. Comparison of Masking Level Difference in Patients with Multiple Sclerosis and Healthy Control Group

    Directory of Open Access Journals (Sweden)

    Soghrat Faghihzadeh

    2012-03-01

    Full Text Available Background and Aim: Multiple sclerosis (MS is a neurological disorder that involves central nervous system. Studies have showed that multiple sclerosis affects behavioral central auditory tests, such as masking release or masking level difference (MLD. The purpose of this study is to compare the masking level difference between multiple sclerosis patients and normal subjects.Methods: This cross sectional and non-interventional study was conducted on 32 multiple sclerosis patients aged between 20-50 years and 32 controls matched for age and gender in Faculty of Rehabilitation, Tehran University of Medical Sciences. masking level difference test was performed on each subject.Results: The mean masking level difference in the two groups was significantly different (p<0.01 however, gender did not prove to play a role in this difference.Conclusion: As part of the multiple sclerosis diagnosis panel, masking level difference test is an efficient modality for evaluation of hearing impairment and monitoring of rehabilitation progress.

  1. The level of emotion control, anxiety, and self-efficacy in the elderly in Bialystok, Poland

    Science.gov (United States)

    Cybulski, Mateusz; Cybulski, Lukasz; Krajewska-Kulak, Elzbieta; Cwalina, Urszula

    2017-01-01

    Purpose The aim of the study was to assess the level of emotion control, anxiety, and self-efficacy in the inhabitants of Bialystok (Poland) aged above 60. Patients and methods The study included 300 people above the age of 60, inhabitants of Bialystok and its neighborhoods: 100 residents of public nursing home, 100 participants of the University of the Third Age in Bialystok, and 100 students of the University of Healthy Senior. The three standardized psychometric scales were used in the study: Courtauld Emotional Control Scale (CECS), State-Trait Anxiety Inventory (STAI), and General Self-Efficacy Scale (GSES). Results The median of the overall score of CECS equaled 54 points, which is considered average in terms of negative emotions acceptance. The mean score of perceiving anxiety as the condition of STAI (X1) was 48 points, while anxiety as a trait of STAI (X2) was 49 points. The overall score for GSES proved that respondents had a subjective feeling of self-efficacy at the level of 29 points out of 40 points possible, which means that their self-efficacy was rather at the high level in their self-assessment. In women, a negative correlation was revealed between the sense of self-efficacy and age (r=−0.320, Page among the elderly residents of public nursing home (r=−0.408, Page) analyzed in the study were found to be correlated significantly with the control of negative emotions, the level of anxiety, and self-efficacy. The study group affiliation was a key variable conditioning the relations between the analyzed features. The elderly residents of public nursing home belonged to the group distinguishing negatively compared to other two study groups. The study respondents were characterized by the relatively high perception of anxiety, which may be as a result of the health and social problem present in this age group. In order to improve the quality of life, the study population should reduce level of perceived anxiety and increase the control of negative

  2. Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study

    Directory of Open Access Journals (Sweden)

    M. Erdemoğlu

    2011-07-01

    Full Text Available In a prospective case-control study, we compared the amniotic fluid amino acid levels in non-immune hydrops fetalis (NIHF and normal fetuses. Eighty fetuses underwent amniocentesis for different reasons at the prenatal diagnosis unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University. Forty of these fetuses were diagnosed with NIHF. The study included 40 women each in the NIHF (mean age: 27.69 ± 4.56 years and control (27.52 ± 5.49 years groups, who had abnormal double- or triple-screening test values with normal fetuses with gestational ages of 23.26 ± 1.98 and 23.68 ± 1.49 weeks at the time of sample collection, respectively. Amniotic fluid amino acid concentrations (intra-assay variation: 2.26-7.85%; interassay variation: 3.45-8.22% were measured using EZ:faast kits (EZ:faast GC/FID free (physiological amino acid kit; Phenomenex, USA by gas chromatography. The standard for quantitation was a mixture of free amino acids from Phenomenex. The levels of 21 amino acids were measured. The mean phosphoserine and serine levels were significantly lower in the NIHF group, while the taurine, α-aminoadipic acid (aaa, glycine, cysteine, NH4, and arginine (Arg levels were significantly higher compared to control. Significant risk variables for the NIHF group and odds coefficients were obtained using a binary logistic regression method. The respective odds ratios and 95% confidence intervals for the risk variables phosphoserine, taurine, aaa, Arg, and NH4 were 3.31 (1.84-5.97, 2.45 (1.56-3.86, 1.78 (1.18-2.68, 2.18 (1.56-3.04, and 2.41 (1.66-3.49, respectively. The significant difference between NIHF and control fetuses suggests that the amniotic fluid levels of some amino acids may be useful for the diagnosis of NIHF.

  3. Effect of Jeju Water on Blood Glucose Levels in Diabetic Patients: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Gwanpyo Koh

    2013-01-01

    Full Text Available Jeju water is the groundwater of Jeju Island, a volcanic island located in Republic of Korea. We investigated whether Jeju water improved glycemic control in patients with diabetes. This was a 12-week single-center, double-blind, randomized, and controlled trial. The subjects daily drank a liter of one of three kinds of water: two Jeju waters (S1 and S2 and Seoul tap water (SS. The primary outcome was the proportion of patients in the per-protocol (PP population achieving glycated hemoglobin (HbA1c < 7.0% at week 12. In total, 196 patients were randomized and analyzed in the intention-to-treat (ITT population (66 consuming S1, 63 consuming S2, and 67 consuming SS; 146 patients were considered in the PP population. There were no significant differences in the primary outcomes of the groups consuming S1, S2, or SS. However, the percentage of patients achieving HbA1c < 8% was significantly higher in the S2 group than in the SS group. In the ITT population, the 12-week HbA1c and fructosamine levels were lower in the S1 group than in the SS group and the 4-, 8-, and 12-week fructosamine levels were lower in the S2 group than in the SS group. Although we failed to achieve the primary outcome, it is possible that the Jeju waters improve glycemic control compared with the Seoul tap water in diabetic patients.

  4. Explicit control of adaptive automation under different levels of environmental stress.

    Science.gov (United States)

    Sauer, Jürgen; Kao, Chung-Shan; Wastell, David; Nickel, Peter

    2011-08-01

    This article examines the effectiveness of three different forms of explicit control of adaptive automation under low- and high-stress conditions, operationalised by different levels of noise. In total, 60 participants were assigned to one of three types of automation design (free, prompted and forced choice). They were trained for 4 h on a highly automated simulation of a process control environment, called AutoCAMS. This was followed by a 4-h testing session under noise exposure and quiet conditions. Measures of performance, psychophysiology and subjective reactions were taken. The results showed that all three modes of explicit control of adaptive automation modes were able to attenuate the negative effects of noise. This was partly due to the fact that operators opted for higher levels of automation under noise. It also emerged that forced choice showed marginal advantages over the two other automation modes. Statement of Relevance: This work is relevant to the design of adaptive automation since it emphasises the need to consider the impact of work-related stressors during task completion. During the presence of stressors, different forms of operator support through automation may be required than under more favourable working conditions.

  5. Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis.

    Science.gov (United States)

    Takamiya, Masanari; Campos-Ortega, Jose A

    2006-04-01

    We investigated the role of hedgehog (Hh) signalling on zebrafish neurulation, focusing on the intimate relationship between neurogenesis and morphogenesis during the neural keel stage. Through the analyses of Hh loss- and gain-of-function phenotypes, we found that Hh signalling controls the neural keel morphogenesis. To investigate underlying mechanisms, we examined cellular elongation polarity in the neural keel of Hh loss- and gain-of-function phenotypes and compared this with the deficient phenotype of a planar cell polarity (PCP) molecule, Trilobite/Strabismus. We found that Hh signalling controls cell elongation polarity of the neuroepithelium at least in part by means of PCP pathway; however, its effects are not strong enough per se to affect keel morphogenesis; instead Hh signalling mainly controls keel morphogenesis by means of affecting both medial and lateral neurogenesis. We devised a method for precise evaluation of neurogenesis in loss- and gain-of-Hh phenotypes that compensates for its delay caused by disturbed morphogenesis. We present a model that Hh signalling exerts level-dependent and binary-opposite effects on medial neurogenesis, whose modification to explain lateral neurogenesis reveals regional differences of underlying mechanisms between the two proneural domains. Such differences seem to be created in part by regional effector signalling; the effects of high Hh-signalling on medial neurogenesis can be reversed in accordance to medial Tri/Stbm level, in a polarity independent manner.

  6. Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levels.

    Science.gov (United States)

    Joshi, Neeraj; Brown, M Scott; Bishop, Douglas K; Börner, G Valentin

    2015-03-05

    During meiosis, Spo11-induced double-strand breaks (DSBs) are processed into crossovers, ensuring segregation of homologous chromosomes (homologs). Meiotic DSB processing entails 5' end resection and preferred strand exchange with the homolog rather than the sister chromatid (homolog bias). In many organisms, DSBs appear gradually along the genome. Here we report unexpected effects of global DSB levels on local recombination events. Early-occurring, low-abundance "scout" DSBs lack homolog bias. Their resection and interhomolog processing are controlled by the conserved checkpoint proteins Tel1(ATM) kinase and Pch2(TRIP13) ATPase. Processing pathways controlled by Mec1(ATR) kinase take over these functions only above a distinct DSB threshold, resulting in progressive strengthening of the homolog bias. We conclude that Tel1(ATM)/Pch2 and Mec1(ATR) DNA damage response pathways are sequentially activated during wild-type meiosis because of their distinct sensitivities to global DSB levels. Moreover, relative DSB order controls the DSB repair pathway choice and, ultimately, recombination outcome.

  7. Water Level Loggers as a Low-Cost Tool for Monitoring of Stormwater Control Measures

    Directory of Open Access Journals (Sweden)

    Laura Toran

    2016-08-01

    Full Text Available Stormwater control measures (SCMs are a key component of watershed health in urbanized areas. SCMs are used to increase infiltration and reduce discharge to streams or storm sewer systems during rain events. Monitoring is important for the evaluation of design and causes of failure in SCMs. However, the expense of monitoring means it is not always included in stormwater control planning. This study shows how low-cost water level loggers can be used to answer certain questions about SCM performance. Five case studies are presented that use water level loggers to evaluate the overflow of basins, compare a traditional stormpipe trench with an infiltration trench, monitor timing of blue roof storage, show the effects of retrofitting a basin, and provide long term performance data. Water level loggers can be used to answer questions about the timing and location of stormwater overflows, which helps to evaluate the effectiveness of SCMs. More expensive monitoring and modeling can be used as a follow up if needed to more thoroughly assess a site. Nonetheless, low-cost monitoring can be a first step in identifying sites that need improvement or additional monitoring.

  8. The impact of climate change and emissions control on future ozone levels: Implications for human health.

    Science.gov (United States)

    Stowell, Jennifer D; Kim, Young-Min; Gao, Yang; Fu, Joshua S; Chang, Howard H; Liu, Yang

    2017-11-01

    Overwhelming evidence has shown that, from the Industrial Revolution to the present, human activities influence ground-level ozone (O3) concentrations. Past studies demonstrate links between O3 exposure and health. However, knowledge gaps remain in our understanding concerning the impacts of climate change mitigation policies on O3 concentrations and health. Using a hybrid downscaling approach, we evaluated the separate impact of climate change and emission control policies on O3 levels and associated excess mortality in the US in the 2050s under two Representative Concentration Pathways (RCPs). We show that, by the 2050s, under RCP4.5, increased O3 levels due to combined climate change and emission control policies, could contribute to an increase of approximately 50 premature deaths annually nationwide in the US. The biggest impact, however, is seen under RCP8.5, where rises in O3 concentrations are expected to result in over 2,200 additional premature deaths annually. The largest increases in O3 are seen in RCP8.5 in the Northeast, the Southeast, the Central, and the West regions of the US. Additionally, when O3 increases are examined by climate change and emissions contributions separately, the benefits of emissions mitigation efforts may significantly outweigh the effects of climate change mitigation policies on O3-related mortality. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Control strategies for carbapenemase-producing Enterobacteriaceae at different levels of the healthcare system.

    Science.gov (United States)

    Asensio, Ángel; Cantero, Mireia; Shaw, Evelyn; Vergara-López, Salvador

    2014-12-01

    There has been a rapid increase in recent years in the incidence of infection and colonization by carbapenemase-producing Enterobacteriaceae (CPE). A number of clusters and outbreaks have been reported, some of which have been contained, providing evidence that these clusters and outbreaks can be managed effectively when the appropriate control measures are implemented. This review outlines strategies recommended to control CPE dissemination both at the healthcare facility level (acute and long-term care) and from the public health point of view. A dedicated prepared plan should be required to prevent the spread of CPE at the hospital level. At the front line, activities should include management of patients at admission and new cases, active surveillance culturing and definition of high-risk groups. High compliance with standard precautions for all patients and full or modified contact precautions for defined categories of patients should be implemented. Long-term care facilities are areas where dissemination can also take place but more importantly they can become a reservoir as patients are admitted and released to other Health care facilities. From the public health point of view, surveillance must be tailored to identify regional spread and interfacility transmission to prevent further dissemination. Finally, a comprehensive set of activities at various levels is necessary to prevent further spread of these bacteria in the community.

  10. Maintenance of CO2 level in a BLSS by controlling solid waste treatment unit

    Science.gov (United States)

    Dong, Yingying; Li, Leyuan; Liu, Hong; Fu, Yuming; Xie, Beizhen; Hu, Dawei; Liu, Dianlei; Dong, Chen; Liu, Guanghui

    A bioregenerative life support system (BLSS) is an artificial closed ecosystem for providing basic human life support for long-duration, far-distance space explorations such as lunar bases. In such a system, the circulation of gases is one of the main factor for realizing a higher closure degree. O2 produced by higher plants goes to humans, as well as microorganisms for the treatment of inedible plant biomass and human wastes; CO2 produced by the crew and microorganisms is provided for plant growth. During this process, an excessively high CO2 level will depress plant growth and may be harmful to human health; and if the CO2 level is too low, plant growth will also be affected. Thus, keeping the balance between CO2 and O2 levels is a crucial problem. In this study, a high-efficiency, controllable solid waste treatment unit is constructed, which adopts microbial fermentation of the mixture of inedible biomass and human wastes. CO2 production during the fermentation process is controlled by adjusting fermentation temperature, aeration rate, moisture, etc., so as to meet the CO2 requirement of plants

  11. The level of emotion control, anxiety, and self-efficacy in the elderly in Bialystok, Poland

    Directory of Open Access Journals (Sweden)

    Cybulski M

    2017-02-01

    Full Text Available Mateusz Cybulski,1 Lukasz Cybulski,2 Elzbieta Krajewska-Kulak,1 Urszula Cwalina3 1Department of Integrated Medical Care, Faculty of Health Sciences, Medical University of Bialystok, Bialystok, 2Faculty of Social Sciences, University of Warmia and Mazury, Olsztyn, 3Department of Statistics and Medical Informatics, Faculty of Health Sciences, Medical University of Bialystok, Bialystok, Poland Purpose: The aim of the study was to assess the level of emotion control, anxiety, and self-efficacy in the inhabitants of Bialystok (Poland aged above 60. Patients and methods: The study included 300 people above the age of 60, inhabitants of Bialystok and its neighborhoods: 100 residents of public nursing home, 100 participants of the University of the Third Age in Bialystok, and 100 students of the University of Healthy Senior. The three standardized psychometric scales were used in the study: Courtauld Emotional Control Scale (CECS, State-Trait Anxiety Inventory (STAI, and General Self-Efficacy Scale (GSES. Results: The median of the overall score of CECS equaled 54 points, which is considered average in terms of negative emotions acceptance. The mean score of perceiving anxiety as the condition of STAI (X1 was 48 points, while anxiety as a trait of STAI (X2 was 49 points. The overall score for GSES proved that respondents had a subjective feeling of self-efficacy at the level of 29 points out of 40 points possible, which means that their self-efficacy was rather at the high level in their self-assessment. In women, a negative correlation was revealed between the sense of self-efficacy and age (r=–0.320, P<0.001. Analyzing the study group affiliation of respondents, a negative correlation was reported between the sense of self-efficacy and age among the elderly residents of public nursing home (r=–0.408, P<0.001. Taking into consideration the study group affiliation of respondents, a positive correlation between anger control (CECS and the sense of

  12. The effects of lavender scent on dental patient anxiety levels: a cluster randomised-controlled trial.

    Science.gov (United States)

    Kritsidima, Metaxia; Newton, Tim; Asimakopoulou, Koula

    2010-02-01

    To review the effect of lavender scent on anticipatory anxiety in dental participants. In a cluster randomized-controlled trial, patients' (N = 340) anxiety was assessed while waiting for a scheduled dental appointment, either under the odor of lavender or with no odor. Current anxiety, assessed by the brief State Trait Anxiety Indicator (STAI-6), and generalized dental anxiety, assessed by the Modified Dental Anxiety Scale (MDAS) were examined. Analyses of variance (anovas) showed that although both groups showed similar, moderate levels of generalized dental anxiety (MDAS F((1,338)) = 2.17, P > 0.05) the lavender group reported significantly lower current anxiety (STAI: F((1,338)) = 74.69, P control group. Although anxiety about future dental visits seems to be unaffected, lavender scent reduces state anxiety in dental patients.

  13. The feeling of doing across levels of analysis: The effects of perceived control on learning

    Directory of Open Access Journals (Sweden)

    Ljubica Chatman

    2011-12-01

    Full Text Available A person's sense of control was initially conceptualized in psychology as either a trait (Rotter, 1966, an attribution style (Weiner, 1979 or self-efficacy belief (Bandura, 1989a. More recent work in social cognition focuses on the process of inferring one's own causality and how the feeling of doing comes about. This investigation centers on a cue based process as leading to the experience of agency. These cues include vision, proprioception, social cues, and action relevant thought (Wegner & Sparrow, 2004. Since the advent of Functional Magnetic Resonance Imaging (fMRI, progress has been made in understanding the neural substrates implicated when one's infers own causality (for review see David, Newen, & Vogeley, 2008. An analysis of the different approaches to studying human agency, reveals their contributions with each level of analysis adding to and refining our understanding of perceived control and its effect on learning.

  14. Multi-Level Energy Management and Optimal Control of a Residential DC Microgrid

    DEFF Research Database (Denmark)

    Diaz, Enrique Rodriguez; Anvari-Moghaddam, Amjad; Quintero, Juan Carlos Vasquez

    2017-01-01

    Extensive exploitation of renewable energies together with the increased role of low-voltage DC (LVDC) micro-sources in the generation mix of the future electricity networks, have become the driving force behind the DC microgrid applications. In this paper, an optimal dispatch model of a resident......Extensive exploitation of renewable energies together with the increased role of low-voltage DC (LVDC) micro-sources in the generation mix of the future electricity networks, have become the driving force behind the DC microgrid applications. In this paper, an optimal dispatch model...... of a residential DC microgrid (R-DCMG) with different distributed generations (DGs) and loads is proposed and implemented as an optimal hierarchical control strategy. A system-level optimizer is designed to calculate the optimal operating points of the controllable energy sources (CESs) when needed, while lower...

  15. Analysis, control and design of a non-inverting buck-boost converter: A bump-less two-level T-S fuzzy PI control.

    Science.gov (United States)

    Almasi, Omid Naghash; Fereshtehpoor, Vahid; Khooban, Mohammad Hassan; Blaabjerg, Frede

    2017-03-01

    In this paper, a new modified fuzzy Two-Level Control Scheme (TLCS) is proposed to control a non-inverting buck-boost converter. Each level of fuzzy TLCS consists of a tuned fuzzy PI controller. In addition, a Takagi-Sugeno-Kang (TSK) fuzzy switch proposed to transfer the fuzzy PI controllers to each other in the control system. The major difficulty in designing fuzzy TLCS which degrades its performance is emerging unwanted drastic oscillations in the converter output voltage during replacing the controllers. Thereby, the fuzzy PI controllers in each level of TLCS structure are modified to eliminate these oscillations and improve the system performance. Some simulations and digital signal processor based experiments are conducted on a non-inverting buck-boost converter to support the effectiveness of the proposed TLCS in controlling the converter output voltage.

  16. Influence of different disease control pesticide strategies on multiple pesticide residue levels in apple

    DEFF Research Database (Denmark)

    Poulsen, Mette Erecius; Naef, A.; Gasser, S.;

    2009-01-01

    % of European Maximum Residue Levels (EU MRL) and that the number of residues present at levels above 0.01 mg kg(-1) should be limited to a maximum of four. The strategies fulfilled the requirement to use combinations of different active substances in order to prevent the emergence of resistance to pesticides......Seven pesticide application strategies were investigated to control apple scab (Venturia inaequalis) and powdery mildew (Podosphaera leucotricha) and, at the same time.. fulfil the new quality standards implemented by some German retailers. These demand that pesticide residues should be below 80....... The trials were conducted at two sites in Switzerland, in 2007, and all strategies and applications were in accordance with actual practice. Four replicates of apple samples from each strategy were then analysed for pesticide residues. The incidence of infection with apple scab and powdery mildew were...

  17. A system level boundary scan controller board for VME applications [to CERN experiments

    CERN Document Server

    Cardoso, N; Da Silva, J C

    2000-01-01

    This work is the result of a collaboration between INESC and LIP in the CMS experiment being conducted at CERN. The collaboration addresses the application of boundary scan test at system level namely the development of a VME boundary scan controller (BSC) board prototype and the corresponding software. This prototype uses the MTM bus existing in the VME64* backplane to apply the 1149.1 test vectors to a system composed of nineteen boards, called here units under test (UUTs). A top-down approach is used to describe our work. The paper begins with some insights about the experiment being conducted at CERN, proceed with system level considerations concerning our work and with some details about the BSC board. The results obtained so far and the proposed work is reviewed in the end of this contribution. (11 refs).

  18. Low-level finite state control of knee joint in paraplegic standing.

    Science.gov (United States)

    Mulder, A J; Veltink, P H; Boom, H B; Zilvold, G

    1992-01-01

    Low-level finite state (locked-unlocked) control is compared with open-loop stimulation of the knee extensor muscles in functional electrical stimulation (FES) induced paraplegic standing. The parameters were: duration of standing, relative torque loss in knee extensor muscles, knee angle stability, average stimulus output and average arm effort during standing. To investigate the impact of external mechanical conditions on controller performance, experiments were performed both under the condition of a freely moving ankle joint and of a mechanically stabilized ankle joint. Finite state control resulted in a 2.5 to 12 times increase of standing duration or in a 1.5 to 5 times decrease of relative torque loss in comparison with open-loop stimulation. Finite state control induced a limit cycle oscillation in the knee joint. Average maximum knee flexion was 6.2 degrees without ankle bracing, and half that value with ankle bracing. Average arm support was 13.9 and 7.5% of the body weight without and with ankle bracing respectively.

  19. Heterogeneity in Autonomic Arousal Level in Perseverative Worry: The Role of Cognitive Control and Verbal Thought

    Science.gov (United States)

    Toh, Gim Y.; Vasey, Michael W.

    2017-01-01

    One puzzle in high worry and generalized anxiety disorder (GAD) is the heterogeneity in the level of autonomic arousal symptoms seen among affected individuals. While current models agree that worry persists, in part, because it fosters avoidance of unpleasant internal experiences, they disagree as to whether worry does so by suppressing activation of autonomic arousal or by fostering persistent autonomic hyperarousal. Our Cognitive Control Model predicts that which pattern of autonomic arousal occurs depends on whether or not a worrier has sufficient cognitive control capacity to worry primarily in a verbal versus imagery-based manner. Because this model has been supported by only one study to date, the present study sought to replicate and extend that study’s findings. Results from an online survey in an unselected sample of over 900 college students provide further support for our model’s central tenet and initial support for its prediction that higher effortful control is associated with a higher percentage of verbal thought during worry. Finally, we report tentative evidence that autonomic arousal symptoms in worry and GAD vary as a function of individual differences in cognitive control capacity because higher capacity is linked to a greater predominance of verbal thought during worry.

  20. Common sole larvae survive high levels of pile-driving sound in controlled exposure experiments.

    Directory of Open Access Journals (Sweden)

    Loes J Bolle

    Full Text Available In view of the rapid extension of offshore wind farms, there is an urgent need to improve our knowledge on possible adverse effects of underwater sound generated by pile-driving. Mortality and injuries have been observed in fish exposed to loud impulse sounds, but knowledge on the sound levels at which (sub-lethal effects occur is limited for juvenile and adult fish, and virtually non-existent for fish eggs and larvae. A device was developed in which fish larvae can be exposed to underwater sound. It consists of a rigid-walled cylindrical chamber driven by an electro-dynamical sound projector. Samples of up to 100 larvae can be exposed simultaneously to a homogeneously distributed sound pressure and particle velocity field. Recorded pile-driving sounds could be reproduced accurately in the frequency range between 50 and 1000 Hz, at zero to peak pressure levels up to 210 dB re 1µPa(2 (zero to peak pressures up to 32 kPa and single pulse sound exposure levels up to 186 dB re 1µPa(2s. The device was used to examine lethal effects of sound exposure in common sole (Solea solea larvae. Different developmental stages were exposed to various levels and durations of pile-driving sound. The highest cumulative sound exposure level applied was 206 dB re 1µPa(2s, which corresponds to 100 strikes at a distance of 100 m from a typical North Sea pile-driving site. The results showed no statistically significant differences in mortality between exposure and control groups at sound exposure levels which were well above the US interim criteria for non-auditory tissue damage in fish. Although our findings cannot be extrapolated to fish larvae in general, as interspecific differences in vulnerability to sound exposure may occur, they do indicate that previous assumptions and criteria may need to be revised.

  1. Coherent Phase Control of Multiphoton Ionization in Three-Level Ladder-Type System

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-An; CHEN Yu-Ting; WANG Zu-Geng; SUN Zhen-Rong

    2009-01-01

    We present the theoretical investigation of photoelectron spectroscopy resulting from the strong field induced multiphoton ionization in a typical three-level ladder-style system.Our theoretical results show that the photoelectron spectral structure can be alternatively steered by spectral phase modulation.This physical mechanism for strong field quantum control is explicitly exploited by the time-dependent dressed state population.It is concluded that the phase-shaped laser pulses can be used to selectively manipulate the multiphoton ionization process in complicated quantum systems.

  2. Coherent control of a V-type three-level system in a single quantum dot.

    Science.gov (United States)

    Wang, Q Q; Muller, A; Cheng, M T; Zhou, H J; Bianucci, P; Shih, C K

    2005-10-28

    In a semiconductor quantum dot, the IIx and IIy transitions to the polarization eigenstates, |x> and |y>, naturally form a three-level V-type system. Using low-temperature polarized photoluminescence spectroscopy, we have investigated the exciton dynamics arising under strong laser excitation. We also explicitly solved the density matrix equations for comparison with the experimental data. The polarization of the exciting field controls the coupling between the otherwise orthogonal states. In particular, when the system is initialized into \\Y>, a polarization-tailored pulse can swap the population into |x>, and vice versa, effectively operating on the exciton spin.

  3. Design and Simulation of a Shunt Active Filter in Application for Control of Harmonic Levels

    CERN Document Server

    Adrian, Gligor

    2010-01-01

    Nowadays, the active filters represent a viable alternative for controlling harmonic levels in industrial consumers electrical installations. It must be noted the availability of many different types of filter configurations that can be used but there is no standard method for rating the active filters. This paper focuses on describing the shunt active filter structure and design. The theoretical concepts underlying the design of shunt active filters are presented. To validate and highlight the performance of shunt active filters a Matlab-Simulink model was developed. Simulation results are also presented.

  4. Control of the upper body accelerations in young and elderly women during level walking

    Directory of Open Access Journals (Sweden)

    Pecoraro Fabrizio

    2008-11-01

    Full Text Available Abstract Background The control of the head movements during walking allows for the stabilisation of the optic flow, for a more effective processing of the vestibular system signals, and for the consequent control of equilibrium. In young individuals, the oscillations of the upper body during level walking are characterised by an attenuation of the linear acceleration going from pelvis to head level. In elderly subjects the ability to implement this motor strategy is reduced. The aim of this paper is to go deeper into the mechanisms through which the head accelerations are controlled during level walking, in both young and elderly women specifically. Methods A stereophotogrammetric system was used to reconstruct the displacement of markers located at head, shoulder, and pelvis level while 16 young (age: 24 ± 4 years and 20 older (age: 72 ± 4 years female volunteers walked at comfortable and fast speed along a linear pathway. The harmonic coefficients of the displacements in the medio-lateral (ML, antero-posterior (AP, and vertical (V directions were calculated via discrete Fourier transform, and relevant accelerations were computed by analytical double differentiation. The root mean square of the accelerations were used to define three coefficients for quantifying the attenuations of the accelerations from pelvis to head, from pelvis to shoulder, and from shoulder to head. Results The coefficients of attenuation were shown to be independent from the walking speed, and hence suitable for group and subject comparison. The acceleration in the AP direction was attenuated by the two groups both from pelvis to shoulder and from shoulder to head. The reduction of the shoulder to head acceleration, however, was less effective in older women, suggesting that the ability to exploit the cervical hinge to attenuate the AP acceleration is challenged in this population. Young women managed to exploit a pelvis to shoulder attenuation strategy also in the ML

  5. Macroscopic assembly by optical control of zmol-level DNA hybridization

    Science.gov (United States)

    Iida, Takuya; Nishimura, Yushi; Tamura, Mamoru; Nishida, Keisuke; Ito, Syoji; Tokonami, Shiho

    2017-04-01

    Remote acceleration of a molecular recognition will open an avenue for the control of various biological functions. Here, we have developed a new principle for the rapid macroscopic assembly based on the light-induced molecular recognition via nanoparticles. Remarkably, as an application of this principle, we have demonstrated the submillimetre network formation triggered by light-induced hybridization of zmol-level DNA within a few minutes. This finding will be used for the rapid and highly sensitive genetic screening without fluorescent labeling.

  6. Plasma progranulin and relaxin levels in PCOS women with normal BMI compared to control healthy subjects

    Directory of Open Access Journals (Sweden)

    Samad Akbarzadeh

    2013-09-01

    Full Text Available Background: Poly Cystic Ovary Syndrome (PCOS is the most commonly encountered endocrine gland disease affecting 5-10 present of women at their reproductive age. This syndrome is associated with type 2 diabetes, dyslipidemia, and obesity. Progranulin and relaxin are adipokins that are related with carbohydrate and lipid metabolism. Due to limited data about progranulin and relaxin plasma levels´ in women with PCOS and normal BMI, this study was conducted. Material and Methods: This study is a cross-sectional. During the study 39 women with PCOS and BMI< 25 on the basis of Rotterdam criteria were chosen as the patient group and 38 healthy women were selected as the control group. The concentration of progranulin and relaxin were measured by ELISA technique. Results: The difference in Plasma concentration of progranulin and relaxin, and also some of the biochemical parameters in the patient group versus to the control group was not significant, but there was significant difference in the concentrations of VLDL, triglyceride (p=0.046, insulin (p=0.016, HOMA-IR (p=0.015, testosterone (p=0.01, and DHEAS (p=0.034 in the patients group compared to the control group. Conclusion: In this study, the difference in Plasma concentration of progranulin and relaxin in the patient group compared to the control group was not significant. It could be inferred that lack of change in plasma level of progranulin and relaxin in women with PCOS is related to BMI<25 and FBS<110. Moreoverestosterones, insulin, DHEAS and HOMA-IR changes could be better predictors of PCOS and its associated diabetes.

  7. Cost effectiveness of tobacco control policies in Vietnam: the case of population-level interventions.

    Science.gov (United States)

    Higashi, Hideki; Truong, Khoa D; Barendregt, Jan J; Nguyen, Phuong K; Vuong, Mai L; Nguyen, Thuy T; Hoang, Phuong T; Wallace, Angela L; Tran, Tien V; Le, Cuong Q; Doran, Christopher M

    2011-05-01

    Tobacco smoking is one of the leading public health problems in the world. It is also possible to prevent and/or reduce the harm from tobacco use through the use of cost-effective tobacco control measures. However, most of this evidence comes from developed countries and little research has been conducted on this issue in developing countries. The objective of this study was to analyse the cost effectiveness of four population-level tobacco control interventions in Vietnam. Four tobacco control interventions were evaluated: excise tax increase; graphic warning labels on cigarette packs; mass media campaigns; and smoking bans (in public or in work places). A multi-state life table model was constructed in Microsoft® Excel to examine the cost effectiveness of the tobacco control intervention options. A government perspective was adopted, with costing conducted using a bottom-up approach. Health improvement was considered in terms of disability-adjusted life-years (DALYs) averted. All assumptions were subject to sensitivity and uncertainty analysis. All the interventions fell within the definition of being very cost effective according to the threshold level suggested by the WHO (i.e. GDP per capita). Graphic warning labels on cigarette packs was the most cost-effective option, followed by excise tax increases, mass media campaigns, public smoking bans and work place smoking bans. If the cost offset was included in the analysis, all interventions would provide cost savings to the government health sector. All four interventions to reduce the harm from tobacco use appear to be highly cost effective and should be considered as priorities in the context of Vietnam. The government may initially consider graphic warning labels and tax increase, followed by other interventions.

  8. The level of cholinergic nucleus basalis activation controls the specificity of auditory associative memory.

    Science.gov (United States)

    Weinberger, Norman M; Miasnikov, Alexandre A; Chen, Jemmy C

    2006-11-01

    Learning involves not only the establishment of memory per se, but also the specific details of its contents. In classical conditioning, the former concerns whether an association was learned while the latter discloses what was learned. The neural bases of associativity have been studied extensively while neural mechanisms of memory specificity have been neglected. Stimulation of the cholinergic nucleus basalis (NBs) paired with a preceding tone induces CS-specific associative memory. As different levels of acetylcholine may be released naturally during different learning situations, we asked whether the level of activation of the cholinergic neuromodulatory system can control the degree of detail that is encoded and retrieved. Adult male rats were tested pre- and post-training for behavioral responses (interruption of ongoing respiration) to tones of various frequencies (1-15 kHz, 70 dB, 2 s). Training consisted of 200 trials/day of tone (8.0 kHz, 70 dB, 2 s) either paired or unpaired with NBs (CS-NBs = 1.8 s) at moderate (65.7+/-9.0 microA, one day) or weak (46.7+/-12.1 microA, three training days) levels of stimulation, under conditions of controlled behavioral state (pre-trial stable respiration rate). Post-training (24 h) responses to tones revealed that moderate activation induced both associative and CS-specific behavioral memory, whereas weak activation produced associative memory lacking frequency specificity. The degree of memory specificity 24 h after training was positively correlated with the magnitude of CS-elicited increase in gamma activity within the EEG during training, but only in the moderate NBs group. Thus, a low level of acetylcholine released by the nucleus basalis during learning is sufficient to induce associativity whereas a higher level of release enables the storage of greater experiential detail. gamma waves, which are thought to reflect the coordinated activity of cortical cells, appear to index the encoding of CS detail. The findings

  9. Pre-irradiation with low-dose 12C6+beam significantly enhances the efficacy of AdCMV-p53 gene therapy in human non-small lung cancer

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The combination of ionizing radiation and gene therapy has been investigated. However, there are very few reports about the combination of heavy-ion irradiation and gene therapy. To determine if the pre-exposure to low-dose heavy ion beam enhances the suppression of AdCMV-p53 on non-small lung cancer (NSLC), the cells pre-irradiated or non-irradiated were infected with 20, 40 MOI of AdCMV-p53. Survival fraction and the relative biology effect (RBE) were determined by clonogenic assay. The results showed that the proportions of p53 positive cells in 12C6+ beam induced AdCMV-p53 infected cells were more than 90%, which were signifi-cantly more than those in γ-ray induced AdCMV-p53 infected cells. The pre-exposure to low-dose 12C6+ beam significantly prevented the G0/G1 arrest and activated G2/M checkpoints. The pre-exposure to 12C6+ beam significantly improved cell to apoptosis. RBEs for the 12C6+ + AdCMV-p53 infection groups were 30%-60%, 20%-130% and 30%-70% more than those for the 12C6+-irradiated only, AdCMV-p53 infected only, and γ-irradiation induced AdCMVp53 infected groups, respectively. The data suggested that the pre-exposure to low-dose 12C6+ beam significantly promotes exogenous p53 expression in NSLC, and the suppression of AdCMV-p53 gene therapy on NSLC.

  10. Pre-irradiation with low-dose 12C6+ beam significantly enhances the efficacy of AdCMV-p53 gene therapy in human non-small lung cancer

    Science.gov (United States)

    Liu, Bing; Zhang, Hong; Li, Wenjian; Li, Qiang; Zhou, Guangming; Xie, Yi; Hao, Jifang; Min, Fengling; Zhou, Qingming; Duan, Xin

    2007-04-01

    The combination of ionizing radiation and gene therapy has been investigated. However, there are very few reports about the combination of heavy-ion irradiation and gene therapy. To determine if the pre-exposure to low-dose heavy ion beam enhances the suppression of AdCMV-p53 on non-small lung cancer (NSLC), the cells pre-irradiated or non-irradiated were infected with 20, 40 MOI of AdCMV-p53. Survival fraction and the relative biology effect (RBE) were determined by clonogenic assay. The results showed that the proportions of p53 positive cells in 12C6+ beam induced AdCMV-p53 infected cells were more than 90%, which were significantly more than those in γ-ray induced AdCMV-p53 infected cells. The pre-exposure to low-dose 12C6+ beam significantly prevented the G0/G1 arrest and activated G2/M checkpoints. The pre-exposure to 12C6+ beam significantly improved cell to apoptosis. RBEs for the 12C6+ + AdCMV-p53 infection groups were 30% 60%, 20% 130% and 30% 70% more than those for the 12C6+-irradiated only, AdCMV-p53 infected only, and γ-irradiation induced AdCMVp53 infected groups, respectively. The data suggested that the pre-exposure to low-dose 12C6+ beam significantly promotes exogenous p53 expression in NSLC, and the suppression of AdCMV-p53 gene therapy on NSLC.

  11. Pre-irradiation with low-dose 12C6+ beam significantly enhances the efficacy of AdCMV-p53 gene therapy in human non-small lung cancer

    Institute of Scientific and Technical Information of China (English)

    LIU Bing; DUAN Xin; ZHANG Hong; LI WenJian; LI Qiang; ZHOU GuangMing; XIE Yi; HAO JiFang; MIN FengLing; ZHOU QingMing

    2007-01-01

    The combination of ionizing radiation and gene therapy has been investigated. However, there are very few reports about the combination of heavy-ion irradiation and gene therapy. To determine if the pre-exposure to low-dose heavy ion beam enhances the suppression of AdCMV-p53 on non-small lung cancer (NSLC), the cells pre-irradiated or non-irradiated were infected with 20, 40 MOl of AdCMV-p53. Survival fraction and the relative biology effect (RBE) were determined by clonogenic assay. The results showed that the proportions of p53 positive cells in 12C6+ beam induced AdCMV-p53 infected cells were more than 90%, which were significantly more than those in γ-ray induced AdCMV-p53 infected cells. The pre-exposure to low-dose 12C6+ beam significantly prevented the G0/G1 arrest and activated G2/M checkpoints. The pre-exposure to 12C6+ beam significantly improved cell to apoptosis. RBEs for the 12C6+ + AdCMV-p53 infection groups were 30%-60%, 20% -130% and 30%-70% more than those for the 12C6+-irradiated only, AdCMV-p53 infected only, and γ-irradiation induced AdCMVp53 infected groups, respectively. The data suggested that the pre-exposure to low-dose 12C6+ beam significantly promotes exogenous p53 expression in NSLC, and the suppression of AdCMV-p53 gene therapy on NSLC.

  12. ARRA-Multi-Level Energy Storage and Controls for Large-Scale Wind Energy Integration

    Energy Technology Data Exchange (ETDEWEB)

    David Wenzhong Gao

    2012-09-30

    The Project Objective is to design innovative energy storage architecture and associated controls for high wind penetration to increase reliability and market acceptance of wind power. The project goals are to facilitate wind energy integration at different levels by design and control of suitable energy storage systems. The three levels of wind power system are: Balancing Control Center level, Wind Power Plant level, and Wind Power Generator level. Our scopes are to smooth the wind power fluctuation and also ensure adequate battery life. In the new hybrid energy storage system (HESS) design for wind power generation application, the boundary levels of the state of charge of the battery and that of the supercapacitor are used in the control strategy. In the controller, some logic gates are also used to control the operating time durations of the battery. The sizing method is based on the average fluctuation of wind profiles of a specific wind station. The calculated battery size is dependent on the size of the supercapacitor, state of charge of the supercapacitor and battery wear. To accommodate the wind power fluctuation, a hybrid energy storage system (HESS) consisting of battery energy system (BESS) and super-capacitor is adopted in this project. A probability-based power capacity specification approach for the BESS and super-capacitors is proposed. Through this method the capacities of BESS and super-capacitor are properly designed to combine the characteristics of high energy density of BESS and the characteristics of high power density of super-capacitor. It turns out that the super-capacitor within HESS deals with the high power fluctuations, which contributes to the extension of BESS lifetime, and the super-capacitor can handle the peaks in wind power fluctuations without the severe penalty of round trip losses associated with a BESS. The proposed approach has been verified based on the real wind data from an existing wind power plant in Iowa. An

  13. Controller Design and Analysis of Spacecraft Automatic Levelling and Equalizing Hoist Device based on Hanging Point Adjustment

    Directory of Open Access Journals (Sweden)

    Tang Laiying

    2016-01-01

    Full Text Available Spacecraft Automatic Levelling and Equalizing Hoist Device (SALEHD is a kind of hoisting device developed for eccentric spacecraft level-adjusting, based on hanging point adjustment by utilizing XY-workbench. To make the device automatically adjust the spacecraft to be levelling, the controller for SALEHD was designed in this paper. Through geometry and mechanics analysis for SALEHD and the spacecraft, the mathematical model of the controller is established. And then, the link of adaptive control and the link of variable structure control were added into the controller to adapt the unknown parameter and eliminate the interference of support vehicle. The stability of the controller was analysed, through constructing Lyapunov energy function. It was proved that the controller system is asymptotically stable, and converged to origin that is equilibrium point. So the controller can be applied in SALEHD availably and safely.

  14. Action recognition depends on observer's level of action control and social personality traits.

    Directory of Open Access Journals (Sweden)

    Sasha Ondobaka

    Full Text Available Humans recognize both the movement (physical goals and action (conceptual goals of individuals with whom they are interacting. Here, we assessed whether spontaneous recognition of others' goals depends on whether the observers control their own behavior at the movement or action level. We also examined the relationship between individual differences in empathy and ASD-like traits, and the processing of other individual's movement and action goals that are known to be encoded in the "mirroring" and "mentalizing" brain networks. In order to address these questions, we used a computer-based card paradigm that made it possible to independently manipulate movement and action congruency of observed and executed actions. In separate blocks, participants were instructed to select either the right or left card (movement-control condition or the higher or lower card (action-control condition, while we manipulated action- and movement-congruency of both actors' goals. An action-congruency effect was present in all conditions and the size of this effect was significantly correlated with self-reported empathy and ASD-like traits. In contrast, movement-congruency effects were only present in the movement-control block and were strongly dependent on action-congruency. These results illustrate that spontaneous recognition of others' behavior depends on the control scheme that is currently adopted by the observer. The findings suggest that deficits in action recognition are related to abnormal synthesis of perceived movements and prior conceptual knowledge that are associated with activations in the "mirroring" and "mentalizing" cortical networks.

  15. DC Bus Control of Back-to-Back Connected Two-Level PWM Rectifier-Five-Level NPC Voltage Source Inverter to Torque Ripple Reduction in Induction Motor

    Directory of Open Access Journals (Sweden)

    Abdelkrim Thameur

    2015-01-01

    Full Text Available This paper proposes a regulation method of back-to-back connected two-level PWM rectifier-five-level Voltage Source Inverter (VSI in order to reduce the torque ripple in induction motor. First part is dedicated to the presentation of the feedback control of two-level PWM rectifier. In the second part, five-level Neutral Point Clamped (NPC voltage source inverter balancing DC bus algorithm is presented. A theoretical analysis with a complete simulation of the system is presented to prove the excellent performance of the proposed technique.

  16. A case-control study to evaluate salivary cortisol levels in patients with dry mouth

    Directory of Open Access Journals (Sweden)

    Vandana Shekar

    2014-01-01

    Full Text Available Objective: The purpose of this study is to evaluate the salivary cortisol levels in patients with dry mouth. Materials and Methods: The study population consisted of 20 patients with a complaint of dry mouth and 20 asymptomatic age- and sex-matched controls. In patients who complained of dry mouth, the salivary flow rate (ml/minute was estimated by measuring the quantity of the saliva collected in the collector. The concentration of cortisol in the saliva (΅g/dl was determined by using a salivary enzyme-linked immunoassay (ELISA kit. Statistical Analysis: The results were evaluated using the Student′s t-test. Results: There was only a mild increase in salivary cortisol in both stimulated and unstimulated saliva in patients with dry mouth compared to the controls (p-value 0.981 and 0.481, respectively, which was not statistically significant. Conclusion: There may not be a clear association between the salivary cortisol level and dry mouth. In older individuals, age-associated salivary gland hypofunction and life changes may be the main risk factors for dry mouth compared to stress and anxiety.

  17. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.

    Directory of Open Access Journals (Sweden)

    Maxim Pilyugin

    Full Text Available Histone chaperones are at the hub of a diverse interaction networks integrating a plethora of chromatin modifying activities. Histone H3/H4 chaperone ASF1 is a target for cell-cycle regulated Tousled-like kinases (TLKs and both proteins cooperate during chromatin replication. However, the precise role of post-translational modification of ASF1 remained unclear. Here, we identify the TLK phosphorylation sites for both Drosophila and human ASF1 proteins. Loss of TLK-mediated phosphorylation triggers hASF1a and dASF1 degradation by proteasome-dependent and independent mechanisms respectively. Consistent with this notion, introduction of phosphorylation-mimicking mutants inhibits hASF1a and dASF1 degradation. Human hASF1b is also targeted for proteasome-dependent degradation, but its stability is not affected by phosphorylation indicating that other mechanisms are likely to be involved in control of hASF1b levels. Together, these results suggest that ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.

  18. Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study

    Directory of Open Access Journals (Sweden)

    Duman Can

    2004-10-01

    Full Text Available Abstract Background Matrix metalloproteinases (MMPs have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degrading enzyme activity in the arterial wall may act as a susceptibility factor for the development of coronary aneurysms. The aim of this study was to investigate the association between MMPs and presence of coronary aneurysms. Methods Thirty patients with aneurysmal coronary artery disease and stable angina were enrolled into study (Group 1. Fourteen coronary artery disease patients with stable angina were selected as control group (Group 2. MMP-1, MMP-3 and C-reactive protein (CRP were measured in peripheral venous blood and matched between the groups. Results Serum MMP-3 level was higher in patients with aneurismal coronary artery disease compared to the control group (20.23 ± 14.68 vs 11.45 ± 6.55 ng/ml, p = 0.039. Serum MMP-1 (13.63 ± 7.73 vs 12.15 ± 6.27 ng/ml, p = 0.52 and CRP levels (4.78 ± 1.47 vs 4.05 ± 1.53 mg/l, p = 0.13 were not significantly different between the groups. Conclusion MMPs can cause arterial wall destruction. MMP-3 may play role in the pathogenesis of coronary aneurysm development through increased proteolysis of extracellular matrix proteins.

  19. Reduction Expansion Synthesis as Strategy to Control Nitrogen Doping Level and Surface Area in Graphene

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    Russell Canty

    2015-10-01

    Full Text Available Graphene sheets doped with nitrogen were produced by the reduction-expansion (RES method utilizing graphite oxide (GO and urea as precursor materials. The simultaneous graphene generation and nitrogen insertion reactions are based on the fact that urea decomposes upon heating to release reducing gases. The volatile byproducts perform two primary functions: (i promoting the reduction of the GO and (ii providing the nitrogen to be inserted in situ as the graphene structure is created. Samples with diverse urea/GO mass ratios were treated at 800 °C in inert atmosphere to generate graphene with diverse microstructural characteristics and levels of nitrogen doping. Scanning electron microscopy (SEM and transmission electron microscopy (TEM were used to study the microstructural features of the products. The effects of doping on the samples structure and surface area were studied by X-ray diffraction (XRD, Raman Spectroscopy, and Brunauer Emmet Teller (BET. The GO and urea decomposition-reduction process as well as nitrogen-doped graphene stability were studied by thermogravimetric analysis (TGA coupled with mass spectroscopy (MS analysis of the evolved gases. Results show that the proposed method offers a high level of control over the amount of nitrogen inserted in the graphene and may be used alternatively to control its surface area. To demonstrate the practical relevance of these findings, as-produced samples were used as electrodes in supercapacitor and battery devices and compared with conventional, thermally exfoliated graphene.

  20. Improving reliability of non-volatile memory technologies through circuit level techniques and error control coding

    Science.gov (United States)

    Yang, Chengen; Emre, Yunus; Cao, Yu; Chakrabarti, Chaitali

    2012-12-01

    Non-volatile resistive memories, such as phase-change RAM (PRAM) and spin transfer torque RAM (STT-RAM), have emerged as promising candidates because of their fast read access, high storage density, and very low standby power. Unfortunately, in scaled technologies, high storage density comes at a price of lower reliability. In this article, we first study in detail the causes of errors for PRAM and STT-RAM. We see that while for multi-level cell (MLC) PRAM, the errors are due to resistance drift, in STT-RAM they are due to process variations and variations in the device geometry. We develop error models to capture these effects and propose techniques based on tuning of circuit level parameters to mitigate some of these errors. Unfortunately for reliable memory operation, only circuit-level techniques are not sufficient and so we propose error control coding (ECC) techniques that can be used on top of circuit-level techniques. We show that for STT-RAM, a combination of voltage boosting and write pulse width adjustment at the circuit-level followed by a BCH-based ECC scheme can reduce the block failure rate (BFR) to 10-8. For MLC-PRAM, a combination of threshold resistance tuning and BCH-based product code ECC scheme can achieve the same target BFR of 10-8. The product code scheme is flexible; it allows migration to a stronger code to guarantee the same target BFR when the raw bit error rate increases with increase in the number of programming cycles.

  1. Seminal plasma total antioxidant capacity and vitamin- C levels in asthenozoospermia: a case- control study

    Directory of Open Access Journals (Sweden)

    Ali Bidmeshkipour

    2010-03-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Defective sperm function is now recognized as one of the most important causes of male infertility. Seminal plasma possesses a rich source of different enzymatic and non-enzymatic antioxidants such as vitamin C (ascorbic acid that protect spermatozoa against oxidative stress as one of the mediators of infertility causing sperm dysfunction and low sperm quality. The aim of this study was investigation of seminal total antioxidant capacity and determination of vitamin C effects on sperm motility. "n"nMethods: We designed a case-control study with a total subject of 62 males. Sperm parameters were analyzed according to World Health Organization guidelines (WHO, 1999. Total antioxidant capacity and vitamin C level of seminal plasma were measured in the 32 normozoospermic as the control group and 32 asthenospermic men as the case group using FRAP (Ferric Reducing of Antioxidants Powers and RP-HPLC (Reverse Phase High Performance Liquid Chromatography methods, respectively. "n"nResults: Our results indicated that total antioxidant capacity levels in the seminal plasma of asthenospermic men were significantly lower than healthy men (p=0.002. In addition, we found a positive correlation between reduced total

  2. Academic Locus of Control, Tendencies Towards Academic Dishonesty and Test Anxiety Levels as the Predictors of Academic Self-Efficacy

    Science.gov (United States)

    Yesilyurt, Etem

    2014-01-01

    Many studies have focused on finding the level of effect that academic locus of control, tendencies towards academic dishonesty, and test anxiety levels have had on academic self-efficacy, and providing a separate explanation ratio for each. The relationship among the effects of the academic locus of control, tendencies towards academic…

  3. Control of a deareador level of a thermoelectric power station using modern control techniques; Control de nivel de un deareador de una central termoelectrica utilizando tecnicas de control moderno

    Energy Technology Data Exchange (ETDEWEB)

    Chavez Estrada, Jose Israel

    1997-01-01

    The present work shows the implementation of the scheme of predictive control IMC (Internal Model Control) in order to control the level of the deareador of a combined cycle thermoelectric power station of (C.C.T.S.). The implementation has the purpose of looking for alternative strategies of control to the classic ones (PID`s) that more efficiently control the variables of interest, in addition to getting into the new control techniques of control. Following the philosophy of predictive control IMC the form to applying this technique is shown, as well as the implementation of this type of controllers. A comparison of predictive control IMC is made with the scheme of conventional control (three control elements PID`s ) used at present to control the level of the deareador in the Combined Cycle Thermoelectric Power stations of Dos Bocas, Veracruz, Mexico and of Gomez Palacio, Durango, Mexico. [Espanol] El presente trabajo muestra la implementacion del esquema de control predictivo IMC (Control con Modelo Interno) con el objeto de controlar el nivel del deareador de una Central Termoelectrica de Ciclo Combinado (C.T.C.C.). La implementacion tiene la finalidad de buscar estrategias de control alternas a las clasicas (PID`s) que controlen mas eficientemente la variable de interes, ademas de incursionar en las nuevas tecnicas de control. Siguiendo la filosofia del control predictivo IMC se muestra la forma de aplicar esta tecnica, asi como la implementacion de este tipo de controladores. Se hace una comparacion del control predictivo IMC con el esquema de control convencional (control de tres elementos PID`s) utilizando actualmente para controlar el nivel del deareador en las centrales termoelectricas de ciclo combinado de Dos Bocas, Veracruz y de Gomez Palacio, Durango en Mexico.

  4. System Level Analysis of a Water PCM HX Integrated Into Orion's Thermal Control System Abstract

    Science.gov (United States)

    Navarro, Moses; Hansen, Scott; Ungar, Eugene; Sheth, Rubik

    2015-01-01

    In a cyclical heat load environment such as low Lunar orbit, a spacecraft's radiators are not sized to reject the full heat load requirement. Traditionally, a supplemental heat rejection device (SHReD) such as an evaporator or sublimator is used to act as a "topper" to meet the additional heat rejection demands. Utilizing a Phase Change Material (PCM) heat exchanger (HX) as a SHReD provides an attractive alternative to evaporators and sublimators as PCM HXs do not use a consumable, thereby leading to reduced launch mass and volume requirements. In continued pursuit of water PCM HX development an Orion system level analysis was performed using Thermal Desktop for a water PCM HX integrated into Orion's thermal control system and in a 100km Lunar orbit. The study analyzed 1) placing the PCM on the Internal Thermal Control System (ITCS) versus the External Thermal Control System (ETCS) 2) use of 30/70 PGW verses 50/50 PGW and 3) increasing the radiator area in order to reduce PCM freeze times. The analysis showed that for the assumed operating and boundary conditions utilizing a water PCM HX on Orion is not a viable option. Additionally, it was found that the radiator area would have to be increased over 20% in order to have a viable water-based PCM HX.

  5. System Level Analysis of a Water PCM HX Integrated into Orion's Thermal Control System

    Science.gov (United States)

    Navarro, Moses; Hansen, Scott; Seth, Rubik; Ungar, Eugene

    2015-01-01

    In a cyclical heat load environment such as low Lunar orbit, a spacecraft's radiators are not sized to reject the full heat load requirement. Traditionally, a supplemental heat rejection device (SHReD) such as an evaporator or sublimator is used to act as a "topper" to meet the additional heat rejection demands. Utilizing a Phase Change Material (PCM) heat exchanger (HX) as a SHReD provides an attractive alternative to evaporators and sublimators as PCM HXs do not use a consumable, thereby leading to reduced launch mass and volume requirements. In continued pursuit of water PCM HX development an Orion system level analysis was performed using Thermal Desktop for a water PCM HX integrated into Orion's thermal control system in a 100km Lunar orbit. The study verified of the thermal model by using a wax PCM and analyzed 1) placing the PCM on the Internal Thermal Control System (ITCS) versus the External Thermal Control System (ETCS) 2) use of 30/70 PGW verses 50/50 PGW and 3) increasing the radiator area in order to reduce PCM freeze times. The analysis showed that for the assumed operating and boundary conditions utilizing a water PCM HX on Orion is not a viable option for any case. Additionally, it was found that the radiator area would have to be increased by at least 40% in order to support a viable water-based PCM HX.

  6. Novel single-phase five-level inverter utilizing digital counter control scheme

    Science.gov (United States)

    Nwosu, Cajethan M.; Umeogamba, Anthony I.; Ogbuka, Cosmas U.

    2017-05-01

    A novel single-phase digital control circuit-based five level inverter (FLI) is presented in this paper. Based on the determined switching angle, one switching cycle of the inverter is divided into segments from which the switching sequence of the inverter switches is digitized. A programmed counter built around J - K flip flops with logic gates provided the needed switching signals for the H-bridge inverter. Proposed inverter is verified through simulation in a MATLAB/SIMULINK environment and simulation results are given. Simulation results show notable reduction in total harmonic distortion (THD) in the inverter output voltage and load current. With an RL load (of 200 Ω and 0.250H), a single digit THD of 8.5 1% for the inverter load current is realized. Comparison of the novel control circuit-dependent FLI with the conventional and contemporary power-circuit-dependent cascaded H-bridge inverter (CHBI) show that the novel FLI is synthesized with lesser number of power circuit and control circuit components.

  7. Carrier-Based Common Mode Voltage Control Techniques in Three-Level Diode-Clamped Inverter

    Directory of Open Access Journals (Sweden)

    Pradyumn Chaturvedi

    2012-01-01

    Full Text Available Switching converters are used in electric drive applications to produce variable voltage, variable frequency supply which generates harmful large dv/dt and high-frequency common mode voltages (CMV. Multilevel inverters generate lower CMV as compared to conventional two-level inverters. This paper presents simple carrier-based technique to control the common mode voltages in multilevel inverters using different structures of sine-triangle comparison method such as phase disposition (PD, phase opposition disposition (POD by adding common mode voltage offset signal to actual reference voltage signal. This paper also presented the method to optimize the magnitude of this offset signal to reduce CMV and total harmonic distortion in inverter output voltage. The presented techniques give comparable performance as obtained in complex space vector-based control strategy, in terms of number of commutations, magnitude, and rate of change of CMV and harmonic profile of inverter output voltage. Simulation and experimental results presented confirm the effectiveness of the proposed techniques to control the common mode voltages.

  8. Hydrology without hillslopes: runoff controls and pathways on a near-level, engineered landscape

    Science.gov (United States)

    Petzold, Halya; Ali, Genevieve

    2015-04-01

    Low relief, artificially drained landscapes like those of the Prairies in south-central Canada have received little consideration in hydrologic study. While topography is generally asserted as the main control of runoff generation, it is unknown whether this is also the case where relief is low, or if in the absence of high relief other landscape characteristics become relatively more influential. To address this knowledge gap, runoff behaviour was analysed via event rainfall-runoff hydrographs and perched water table level at 6 study sites to infer dominant runoff processes and their control factors. Instrumentation was deployed in the Catfish Creek watershed, a 642 km2 near-level, mixed land use and engineered Prairie watershed located 90 km northeast of Winnipeg, Manitoba, Canada. Specifically, surface water levels were measured at the outlet of six sub-watersheds while perched water table levels were monitored in riparian areas. At each site, rainfall events were delineated and rainfall-runoff parameters, perched water table maximum rise and antecedent rainfall variables (as surrogates for antecedent moisture conditions or AMCs) were calculated on an event basis. Landscape characteristics, including elevation, slope, and land use and land cover statistics, were also determined for each sub-watershed. Correlation analysis and principal component analysis were then carried out including all variables. Rainfall-runoff responses were highly variable across sites. Event hydrographs were generally characterized by short lag times and initial abstractions which correlated moderately to total event rainfall. However, sub-watersheds characteristics did not influence the different hydrograph characteristics recorded across sites. Threshold behaviour was observed only in the two study sub-watersheds of greatest relief. Runoff generation was hypothesized to occur predominantly as Hortonian overland flow, although the dominant runoff process shifted under certain moisture

  9. Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.

    Directory of Open Access Journals (Sweden)

    Eva Herrero

    2016-02-01

    Full Text Available The accurate segregation of chromosomes during cell division is achieved by attachment of chromosomes to the mitotic spindle via the kinetochore, a large multi-protein complex that assembles on centromeres. The budding yeast kinetochore comprises more than 60 different proteins. Although the structure and function of many of these proteins has been investigated, we have little understanding of the steady state regulation of kinetochores. The primary model of kinetochore homeostasis suggests that kinetochores assemble hierarchically from the centromeric DNA via the inclusion of a centromere-specific histone into chromatin. We tested this model by trying to perturb kinetochore protein levels by overexpressing an outer kinetochore gene, MTW1. This increase in protein failed to change protein recruitment, consistent with the hierarchical assembly model. However, we find that deletion of Psh1, a key ubiquitin ligase that is known to restrict inner kinetochore protein loading, does not increase levels of outer kinetochore proteins, thus breaking the normal kinetochore stoichiometry. This perturbation leads to chromosome segregation defects, which can be partially suppressed by mutation of Ubr2, a second ubiquitin ligase that normally restricts protein levels at the outer kinetochore. Together these data show that Psh1 and Ubr2 synergistically control the amount of proteins at the kinetochore.

  10. CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells.

    Science.gov (United States)

    Llobet, D; Eritja, N; Encinas, M; Llecha, N; Yeramian, A; Pallares, J; Sorolla, A; Gonzalez-Tallada, F J; Matias-Guiu, X; Dolcet, X

    2008-04-17

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising antineoplastic agent because of its ability to selectively kill tumoral cells. However, some cancer cells are resistant to TRAIL-induced apoptosis. We have previously demonstrated that in endometrial carcinoma cells such resistance is caused by elevated FLICE-inhibitory protein (FLIP) levels. The present study focuses on the mechanisms by which FLIP could be modulated to sensitize endometrial carcinoma cells to TRAIL-induced apoptosis. We find that inhibition of casein kinase (CK2) sensitizes endometrial carcinoma cells to TRAIL- and Fas-induced apoptosis. CK2 inhibition correlates with a reduction of FLIP protein, suggesting that CK2 regulates resistance to TRAIL and Fas by controlling FLIP levels. FLIP downregulation correlates with a reduction of mRNA and is prevented by addition of the MG-132, suggesting that CK2 inhibition results in a proteasome-mediated degradation of FLIP. Consistently, forced expression of FLIP restores resistance to TRAIL and Fas. Moreover, knockdown of either FADD or caspase-8 abrogates apoptosis triggered by inhibition of CK2, indicating that CK2 sensitization requires formation of functional DISC. Finally, because of the possible role of both TRAIL and CK2 in cancer therapy, we demonstrate that CK2 inhibition sensitizes primary endometrial carcinoma explants to TRAIL apoptosis. In conclusion, we demonstrate that CK2 regulates endometrial carcinoma cell sensitivity to TRAIL and Fas by regulating FLIP levels.

  11. Invariant Surface EMG Feature Against Varying Contraction Level for Myoelectric Control Based on Muscle Coordination.

    Science.gov (United States)

    He, Jiayuan; Zhang, Dingguo; Sheng, Xinjun; Li, Shunchong; Zhu, Xiangyang

    2015-05-01

    Variations in muscle contraction effort have a substantial impact on performance of pattern recognition based myoelectric control. Though incorporating changes into training phase could decrease the effect, the training time would be increased and the clinical viability would be limited. The modulation of force relies on the coordination of multiple muscles, which provides a possibility to classify motions with different forces without adding extra training samples. This study explores the property of muscle coordination in the frequency domain and found that the orientation of muscle activation pattern vector of the frequency band is similar for the same motion with different force levels. Two novel features based on discrete Fourier transform and muscle coordination were proposed subsequently, and the classification accuracy was increased by around 11% compared to the traditional time domain feature sets when classifying nine classes of motions with three different force levels. Further analysis found that both features decreased the difference among different forces of the same motion ) and maintained the distance among different motions p > 0.1). This study also provided a potential way for simultaneous classification of hand motions and forces without training at all force levels.

  12. Comparison of the pain levels of computer-controlled and conventional anesthesia techniques in prosthodontic treatment

    Directory of Open Access Journals (Sweden)

    Murat Yenisey

    2009-10-01

    Full Text Available OBJECTIVE: The objective of this study was to compare the pain levels on opposite sides of the maxilla at needle insertion during delivery of local anesthetic solution and tooth preparation for both conventional and anterior middle superior alveolar (AMSA technique with the Wand computer-controlled local anesthesia application. MATERIAL AND METHODS: Pain scores of 16 patients were evaluated with a 5-point verbal rating scale (VRS and data were analyzed nonparametrically. Pain differences at needle insertion, during delivery of local anesthetic, and at tooth preparation, for conventional versus the Wand technique, were analyzed using the Mann-Whitney U test (p=0.01. RESULTS: The Wand technique had a lower pain level compared to conventional injection for needle insertion (p0.05. CONCLUSIONS: The AMSA technique using the Wand is recommended for prosthodontic treatment because it reduces pain during needle insertion and during delivery of local anaesthetic. However, these two techniques have the same pain levels for tooth preparation.

  13. Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.

    Directory of Open Access Journals (Sweden)

    Eva Herrero

    2016-02-01

    Full Text Available The accurate segregation of chromosomes during cell division is achieved by attachment of chromosomes to the mitotic spindle via the kinetochore, a large multi-protein complex that assembles on centromeres. The budding yeast kinetochore comprises more than 60 different proteins. Although the structure and function of many of these proteins has been investigated, we have little understanding of the steady state regulation of kinetochores. The primary model of kinetochore homeostasis suggests that kinetochores assemble hierarchically from the centromeric DNA via the inclusion of a centromere-specific histone into chromatin. We tested this model by trying to perturb kinetochore protein levels by overexpressing an outer kinetochore gene, MTW1. This increase in protein failed to change protein recruitment, consistent with the hierarchical assembly model. However, we find that deletion of Psh1, a key ubiquitin ligase that is known to restrict inner kinetochore protein loading, does not increase levels of outer kinetochore proteins, thus breaking the normal kinetochore stoichiometry. This perturbation leads to chromosome segregation defects, which can be partially suppressed by mutation of Ubr2, a second ubiquitin ligase that normally restricts protein levels at the outer kinetochore. Together these data show that Psh1 and Ubr2 synergistically control the amount of proteins at the kinetochore.

  14. Fighting Corruption when Existing Corruption-Control Levels Count: What do Wealth-Effects Tell us in Africa?

    OpenAIRE

    Simplice A, Asongu

    2013-01-01

    Why are some nations more effective at battling corruption than others? Are there different determinants in the fight against corruption across developing nations? Do income-levels matter in the fight against corruption when existing corruption-control levels also matter? In other words, how does the wealth of nations matter in the fight against corruption when corruption is assessed throughout the conditional distribution of corruption-control from countries with low initial levels of corrup...

  15. Fighting corruption when existing corruption-control levels count : what do wealth-effects tell us in Africa?

    OpenAIRE

    Simplice A, Asongu

    2012-01-01

    Why are some nations more effective at battling corruption than others? Are there different determinants in the fight against corruption across developing nations? Do income-levels matter in the fight against corruption when existing corruption-control levels also matter? In other words, how does the wealth of nations matter in the fight against corruption when corruption is assessed throughout the conditional distribution of corruption-control from countries with low initial levels of corrup...

  16. Radiation Hard Silicon Photonics Mach-Zehnder Modulator for HEP applications: all-Synopsys SentaurusTM Pre-Irradiation Simulation

    CERN Document Server

    Cammarata, Simone

    2017-01-01

    Silicon Photonics may well provide the opportunity for new levels of integration between detectors and their readout electronics. This technology is thus being evaluated at CERN in order to assess its suitability for use in particle physics experiments. In order to check the agreement with measurements and the validity of previous device simulations, a pure Synopsys SentaurusTM simulation of an un-irradiated Mach-Zehnder silicon modulator has been carried out during the Summer Student project. Index Terms—Silicon Photonics, Mach-Zehnder modulator, electro-optic simulation, Synopsys SentaurusTM, electro-optic measurement, HEP.

  17. Measurement and Management of the Level of Quality Control Process in SoC (System on Chip Embedded Software Development

    Directory of Open Access Journals (Sweden)

    Ki-won Song

    2012-04-01

    quality control activities and it is desirable to create a quality process to integrally represent overall level of quality control activities performed while developing the software deliverables. With the quality process, it is possible to evaluate whether enough quality control activities are performed for the project officially and secure the quality of the software deliverables before it is delivered to the customers.

  18. Evaluation of the effectiveness of insecticide treated materials for household level dengue vector control.

    Directory of Open Access Journals (Sweden)

    Veerle Vanlerberghe

    Full Text Available OBJECTIVE: To assess the operational effectiveness of long-lasting insecticide treated materials (ITMs, when used at household level, for the control of Aedes aegypti in moderately infested urban and suburban areas. METHODS: In an intervention study, ITMs consisting of curtains and water jar-covers (made from PermaNet were distributed under routine field conditions in 10 clusters (5 urban and 5 suburban, with over 4000 houses, in Trujillo, Venezuela. Impact of the interventions were determined by comparing pre-and post-intervention measures of the Breteau index (BI, number of positive containers/100 houses and pupae per person index (PPI, and by comparison with indices from untreated areas of the same municipalities. The effect of ITM coverage was modeled. RESULTS: At distribution, the proportion of households with ≥1 ITM curtain was 79.7% in urban and 75.2% in suburban clusters, but decreased to 32.3% and 39.0%, respectively, after 18 months. The corresponding figures for the proportion of jars using ITM covers were 34.0% and 50.8% at distribution and 17.0% and 21.0% after 18 months, respectively. Prior to intervention, the BI was 8.5 in urban clusters and 42.4 in suburban clusters, and the PPI was 0.2 and 0.9, respectively. In both urban and suburban clusters, the BI showed a sustained 55% decrease, while no discernable pattern was observed at the municipal level. After controlling for confounding factors, the percentage ITM curtain coverage, but not ITM jar-cover coverage, was significantly associated with both entomological indices (Incidence Rate Ratio = 0.98; 95%CI 0.97-0.99. The IRR implied that ITM curtain coverage of at least 50% was necessary to reduce A. aegypti infestation levels by 50%. CONCLUSION: Deployment of insecticide treated window curtains in households can result in significant reductions in A. aegypti levels when dengue vector infestations are moderate, but the magnitude of the effect depends on the coverage attained

  19. Locus of control, self-efficacy, and the mediating effect of outcome control: predicting course-level and global outcomes in an academic context.

    Science.gov (United States)

    Au, Evelyn W M

    2015-01-01

    The current study utilizes Skinner's framework to examine the unique contributions of internal locus of control, self-efficacy, and perceived outcome control over course performance on students' academic experiences. Undergraduate students (N = 225) took part in a longitudinal study and completed two surveys (Time 1: just before their mid-term exams; Time 2: just before their final exam in the same semester). Both locus of control and self-efficacy at Time 1 predicted course-level perceived control over course performance at Time 2. Student-level perceived control over course performance at Time 2 mediated the relationship between self-efficacy at Time 1 and course-level perseverance, course-specific stress, and course enjoyment at Time 2. For global perceived stress and life satisfaction measured at Time 2, both locus of control and self-efficacy at Time 1 had only a direct effect on global perceived stress at Time 2, but only self-efficacy at Time 1 predicted life satisfaction at Time 2. Both locus of control and self-efficacy uniquely contribute to students' academic experiences. Student-level perceived control plays an important mediating role between locus of control and self-efficacy at Time 1, and course-level perseverance, course-specific stress, and course enjoyment at Time 2.

  20. Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

    Science.gov (United States)

    Toonen, Ruud F. G.; Wierda, Keimpe; Sons, Michèle S.; de Wit, Heidi; Cornelisse, L. Niels; Brussaard, Arjen; Plomp, Jaap J.; Verhage, Matthijs

    2006-01-01

    Prompt recovery after intense activity is an essential feature of most mammalian synapses. Here we show that synapses with reduced expression of the presynaptic gene munc18-1 suffer from increased depression during intense stimulation at glutamatergic, GABAergic, and neuromuscular synapses. Conversely, munc18-1 overexpression makes these synapses recover faster. Concomitant changes in the readily releasable vesicle pool and its refill kinetics were found. The number of vesicles docked at the active zone and the total number of vesicles per terminal correlated with both munc18-1 expression levels and the size of the releasable vesicle pool. These data show that varying expression of a single gene controls synaptic recovery by modulating the number of docked, release-ready vesicles and thereby replenishment of the secretion capacity. PMID:17110441

  1. Polarized control of Goos-Hänchen shifts in four-level quantized graphene nanostructures

    Science.gov (United States)

    Solookinejad, Gh; Jabbari, M.; Panahi, M.; Ahmadi Sangachin, E.

    2017-01-01

    In this paper, we discuss Goos-Hänchen (GH) shifts of both reflected and transmitted light beams through a cavity containing single-layer graphene nanostructures. The Landau levels of a single layer graphene medium under a strong magnetic field can interact with infrared and terahertz signal radiation. Therefore, the GH shifts in both reflected and transmitted light beams can be obtained in the infrared and terahertz regions of radiation. We have realized that by controlling some adjustable parameters of the system, such as frequency detuning of applied fields, the Rabi frequency of a coupling field and the polarization of coupling light, the GH shifts can be manipulated in the infrared and terahertz regions. Moreover, the thickness of the intracavity medium is also considered as an important parameter on the behavior of GH shifts spectra.

  2. The Use of BPMN for Modelling The MES Level in Information and Control Systems

    Directory of Open Access Journals (Sweden)

    Peter Michalik

    2013-07-01

    Full Text Available This paper describes how to use the process map to model the MES level of information and control systems. In the practical application, the BPMN standard was used for the design of the function of the management maintenance, which, according MES organization, is one of the 11 basic MES functions. The application was implemented on the flexible production line, located in the laboratory at the Department of Cybernetics and Artificial Intelligence. In this article, there is only one BPMN model of  a MES function from the set of modelled functions in our laboratory. These functions were also modelled by the UML Activity Diagram. Although the UML model is not included in this article, there is a comparison of these approaches based on selected criteria and our experiences with modelling in the laboratory at the university.

  3. ADJUSTMENT ERRORS IN ASCENDING AND DESCENDING PHASES OF TARGET LEVEL IN CONTROLLED FORCE EXERTION.

    Science.gov (United States)

    Kubota, Hiroshi; Demura, Shinichi

    2015-10-01

    Hand grip force adjustment errors to ascending and descending phases of a sinusoidal target force in a controlled force exertion (CFE) test were measured and the laterality of responses evaluated. 75 men (M age = 19.6 yr., SD = 1.6) performed the CFE test after one practice trial by matching handgrip force to target level (5-25% of maximal grip force). The CFE errors in ascending and descending phases of the target force were calculated as the absolute differences between actual force and target force in each phase. There were significantly smaller CFE errors in the ascending phase for both dominant and non-dominant hands, but CFE error for the dominant hand was significantly smaller in both phases. Therefore, error in force exertion in the ascending and descending phases of the target force differed, and laterality influenced error in both phases.

  4. Minimum Variance Distortionless Response Beamformer with Enhanced Nulling Level Control via Dynamic Mutated Artificial Immune System

    Directory of Open Access Journals (Sweden)

    Tiong Sieh Kiong

    2014-01-01

    Full Text Available In smart antenna applications, the adaptive beamforming technique is used to cancel interfering signals (placing nulls and produce or steer a strong beam toward the target signal according to the calculated weight vectors. Minimum variance distortionless response (MVDR beamforming is capable of determining the weight vectors for beam steering; however, its nulling level on the interference sources remains unsatisfactory. Beamforming can be considered as an optimization problem, such that optimal weight vector should be obtained through computation. Hence, in this paper, a new dynamic mutated artificial immune system (DM-AIS is proposed to enhance MVDR beamforming for controlling the null steering of interference and increase the signal to interference noise ratio (SINR for wanted signals.

  5. Using inferential sensors for quality control of Everglades Depth Estimation Network water-level data

    Science.gov (United States)

    Petkewich, Matthew D.; Daamen, Ruby C.; Roehl, Edwin A.; Conrads, Paul A.

    2016-09-29

    The Everglades Depth Estimation Network (EDEN), with over 240 real-time gaging stations, provides hydrologic data for freshwater and tidal areas of the Everglades. These data are used to generate daily water-level and water-depth maps of the Everglades that are used to assess biotic responses to hydrologic change resulting from the U.S. Army Corps of Engineers Comprehensive Everglades Restoration Plan. The generation of EDEN daily water-level and water-depth maps is dependent on high quality real-time data from water-level stations. Real-time data are automatically checked for outliers by assigning minimum and maximum thresholds for each station. Small errors in the real-time data, such as gradual drift of malfunctioning pressure transducers, are more difficult to immediately identify with visual inspection of time-series plots and may only be identified during on-site inspections of the stations. Correcting these small errors in the data often is time consuming and water-level data may not be finalized for several months. To provide daily water-level and water-depth maps on a near real-time basis, EDEN needed an automated process to identify errors in water-level data and to provide estimates for missing or erroneous water-level data.The Automated Data Assurance and Management (ADAM) software uses inferential sensor technology often used in industrial applications. Rather than installing a redundant sensor to measure a process, such as an additional water-level station, inferential sensors, or virtual sensors, were developed for each station that make accurate estimates of the process measured by the hard sensor (water-level gaging station). The inferential sensors in the ADAM software are empirical models that use inputs from one or more proximal stations. The advantage of ADAM is that it provides a redundant signal to the sensor in the field without the environmental threats associated with field conditions at stations (flood or hurricane, for example). In the

  6. Fabrication and Pre-irradiation Characterization of a Minor Actinide and Rare Earth Containing Fast Reactor Fuel Experiment for Irradiation in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Timothy A. Hyde

    2012-06-01

    The United States Department of Energy, seeks to develop and demonstrate the technologies needed to transmute the long-lived transuranic actinide isotopes contained in spent nuclear fuel into shorter lived fission products, thereby decreasing the volume of material requiring disposal and reducing the long-term radiotoxicity and heat load of high-level waste sent to a geologic repository. This transmutation of the long lived actinides plutonium, neptunium, americium and curium can be accomplished by first separating them from spent Light Water Reactor fuel using a pyro-metalurgical process, then reprocessing them into new fuel with fresh uranium additions, and then transmuted to short lived nuclides in a liquid metal cooled fast reactor. An important component of the technology is developing actinide-bearing fuel forms containing plutonium, neptunium, americium and curium isotopes that meet the stringent requirements of reactor fuels and materials.

  7. [Trends in the level of control of patients with type 2 diabetes from 2010 to 2015].

    Science.gov (United States)

    Herrero Gil, Ana María; Pinillos Robles, Javier; Sabio Repiso, Patricia; Martín Maldonado, José Luis; Garzón González, Gerardo; Gil de Miguel, Ángel

    2017-08-21

    Aim: To examine the trend in the level of control of glycated haemoglobin (HbA1c), blood pressure (BP), and LDL-cholesterol (LDL) in patients with type 2 diabetes mellitus between 2010 and 2015. Setting: 3 cut-offs in the years 2010, 2013, and 2015. Southeast area of Madrid. Descriptive and cross-sectional epidemiological study. Patients diagnosed and registered with type 2 diabetes. N=41,096 (2010), n=49,658 (2013), n=6,674 (2015) MAIN MEASUREMENTS: Measurement or not in the last year of HbA1c, BP, and LDL. Control of HbA1c (<7% individual targeting), BP (<140/90mmHg), and LDL (<100mg/dL, if cardiovascular disease <70mg/dL). Data were collected from electronic records of clinical history. The Chi-square test was used. The percentages of patients with each parameter measured in 2010, 2013 and 2015 were: HbA1c: 36.4%, 37.0%, 62.0% (P<.001); BP: 33.2%, 43.3%, 65.0% (P<.001); LDL: 32.9%, 33.2%, 43.5% (P<.001). The percentages of patients with each parameter measured and controlled in 2010, 2013, and 2015 were: HbA1c: 59.6%, 59.1%, 79.6% (P<.001); BP: 74.9%, 67.4%, 79.2% (P<.001); LDL: 41.8%, 58.3%, 58.8% (P<.001) CONCLUSION: In the 2010-2015 period, a sustained but insufficient trend of better control of HbA1c, BP and LDL was observed in patients with diabetes. The frequency of the measurements of these parameters improved more than the control of them. It seems that efforts to improve care for the patient with diabetes pay off, but they still have to be maintained. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  8. Transformer less based modified cascaded seven levels H- bridge inverter control of DSTATCOM

    Directory of Open Access Journals (Sweden)

    Ganesh Prasad Reddy,

    2010-11-01

    Full Text Available This paper studies an investigation of Transformer less Based Modified Cascaded Seven-Level (TBMCSL H – bridge Inverter is used in a Distribution Static Compensator (DSTATCOM in Power System (PS, making use of TBMCSL advantages of low harmonics distortion, reduced number of switches and suppressed switching losses. In order to improve the power factor, compensate the reactive power and eliminatethe Total Harmonics Distortion (THD drawn from a Non-Liner Diode Rectifier Load (NLDRL of DSTATCOM, we propose a Sub-Harmonics Pulse Width Modulation (SHPWM technique is used as control for the switches of TBHSL H – bridge Inverter. The D-Q reference frame theory is used to generate the reference compensating currents for DSTATCOM and Proportional and Integral (PI control is used for capacitors dc voltage regulation for DSTATCOM. A TBMCSL H – bridge Inverter is considered for shunt compensation of a 9 kV distribution system. The results are verified through MatLab/Simulink software package.

  9. Low-level laser therapy: Case-control study in dogs with sterile pyogranulomatous pododermatitis

    Directory of Open Access Journals (Sweden)

    Roberta Perego

    2016-08-01

    Full Text Available Aim: Low-level laser therapy (LLLT is a therapeutic photobiostimulation with properties in reducing swelling, inflammation, and promoting tissue healing. The objective of this pilot study was to evaluate LLLT in sterile pyogranulomatous pododermatitis in five dogs. Materials and Methods: In each dog, one lesion was designated as the control (treated with a 0.0584% hydrocortisone aceponate spray, and one or more other lesions were treated with a gallium aluminum arsenide-laser, daily for 5 days. Lesions were scored before treatment (D0, at the end (D4, 16 days after the last laser treatment (D20, and after 2 months (D65. Results: Comparing the treated lesion group with the control lesion group, the clinical score was similar at D0, whereas there was a statistically significant difference at D4 and D20; in the treated group over time, there was a statistically significant improvement between D0, D4, and D20. Lesion recurrence was absent in more than 50% of the treated lesions at D65. No adverse reactions were reported. Conclusion: Given the positive results of this first clinical study, it would be interesting to extend the study to confirm the validity of this type of therapy in sterile pyogranulomatous pododermatitis in the dog.

  10. The effect of paternal age on offspring intelligence and personality when controlling for paternal trait level.

    Directory of Open Access Journals (Sweden)

    Ruben C Arslan

    Full Text Available Paternal age at conception has been found to predict the number of new genetic mutations. We examined the effect of father's age at birth on offspring intelligence, head circumference and personality traits. Using the Minnesota Twin Family Study sample we tested paternal age effects while controlling for parents' trait levels measured with the same precision as offspring's. From evolutionary genetic considerations we predicted a negative effect of paternal age on offspring intelligence, but not on other traits. Controlling for parental intelligence (IQ had the effect of turning an initially positive association non-significantly negative. We found paternal age effects on offspring IQ and Multidimensional Personality Questionnaire Absorption, but they were not robustly significant, nor replicable with additional covariates. No other noteworthy effects were found. Parents' intelligence and personality correlated with their ages at twin birth, which may have obscured a small negative effect of advanced paternal age (<1% of variance explained on intelligence. We discuss future avenues for studies of paternal age effects and suggest that stronger research designs are needed to rule out confounding factors involving birth order and the Flynn effect.

  11. Factors Controlling the Metal Levels in Headwater Stream Draining an Agroforestry Catchment (Galicia, NW Spain)

    Science.gov (United States)

    Palleiro, Laura; Rodríguez-Blanco, M. Luz; Mercedes Taboada-Castro, M.; Taboada-Castro, M. Teresa

    2016-10-01

    Concentrations of Al, Fe, Mn, Cu and Zn (dissolved and particulate), suspended sediment, dissolved organic carbon, and pH and discharge were determined during a 3-year period in a stream water of an agroforestry catchment in Galicia (NW Spain). The objective of this study is to investigate the role of these variables in the control of dissolved and particulate concentrations of each metal in the stream water. The soils in the catchment are developed on metamorphic schist. Stream water samples were collected at the catchment outlet every 15 days and more frequently with increased stream flows. Metal concentrations were measured by ICP- MS. Pearson correlation coefficients were calculated to examine the possible associations between metals and the four variables under consideration. Stepwise multiple regressions were applied to determine which predictor variables have the strongest influences on controlling concentrations of each metal in the stream. The results showed that metal concentrations were relatively low (Fe > Al > Mn > Zn > Cu), but particulate metals were predominant over those dissolved. Stepwise multiple regression analysis revealed that the most important variable to explain dissolved concentrations for Al, Fe and Cu was the dissolved organic carbon, whereas the suspended sediment was for dissolved Zn and the discharge was for dissolved Mn. The suspended sediment was also a good predictor of particulate metal levels.

  12. The effect of paternal age on offspring intelligence and personality when controlling for paternal trait level.

    Science.gov (United States)

    Arslan, Ruben C; Penke, Lars; Johnson, Wendy; Iacono, William G; McGue, Matt

    2014-01-01

    Paternal age at conception has been found to predict the number of new genetic mutations. We examined the effect of father's age at birth on offspring intelligence, head circumference and personality traits. Using the Minnesota Twin Family Study sample we tested paternal age effects while controlling for parents' trait levels measured with the same precision as offspring's. From evolutionary genetic considerations we predicted a negative effect of paternal age on offspring intelligence, but not on other traits. Controlling for parental intelligence (IQ) had the effect of turning an initially positive association non-significantly negative. We found paternal age effects on offspring IQ and Multidimensional Personality Questionnaire Absorption, but they were not robustly significant, nor replicable with additional covariates. No other noteworthy effects were found. Parents' intelligence and personality correlated with their ages at twin birth, which may have obscured a small negative effect of advanced paternal age (intelligence. We discuss future avenues for studies of paternal age effects and suggest that stronger research designs are needed to rule out confounding factors involving birth order and the Flynn effect.

  13. Application of the heterogeneous (HG) blankets for controlling the base structure vibration levels

    Science.gov (United States)

    Gautam, Ashwini; Fuller, C. R.; Carneal, James

    2005-09-01

    This work presents an extensive analysis of the properties of the heterogeneous blankets (HGs) and their effectiveness in controlling the vibration of the base structures. The HG blankets act as a distributed vibration absorbers consisting of mass inhomogeneities inside a layer of porous media (acoustic foam). To asses the effectiveness of these HG blankets in controlling the vibration of the base structure (plate), detailed finite element (FE) models of the foam, the HG blanket, and the plate have been developed. The foam has been dicretized using the eight node hexahedral elements. The HG blanket model consists of the foam model with point masses attached to the nodes of the elements. The structural (plate) domain is discretized using four node rectangular plate elements. Each of the FE models has been individually validated by comparing the numerical results with their respective analytical and experimental results. The structural and the HG blanket FE models were then combined into a larger FE model comprised of a base plate with the HG treatment on its surface. The results from this numerical model have shown that there is a significant reduction in the vibration levels of the base plate due to the HG treatment on it.

  14. Randomized, controlled trial of three levels of critical incident stress intervention.

    Science.gov (United States)

    Macnab, Andrew; Sun, Charles; Lowe, John

    2003-01-01

    Stress debriefing following exposure to a critical incident is becoming more prevalent. Its aim is to prevent or minimize the development of excessive stress response symptoms that lead to loss of productivity or effectiveness in the workplace or at home. There is little evidence that any form of psychological debriefing is effective. This study evaluated the effectiveness of three intervention strategies, and attempted to correlate the symptoms with the severity of the incident and level of intervention. A randomized, controlled trial of three levels of critical stress intervention was conducted in the British Columbia Ambulance Service (BCAS), in British Columbia, Canada, among paramedics and emergency medical technicians (EMTs), reporting critical incident stress. Outcomes were measured at one week (Stanford Acute Stress Reaction Questionnaire (SASRQ), the Life Impact Score (LIS), and Schedule of Recent Events (SRE)), and at three months and six months following the intervention (Impact of Events (IE), Coping Mechanisms, LIS, and SRE). Fifty calls were received during the 26-month study period (incident and scores on the SASRQ, IE, or LIS, or between any of these scores. There was no consistent pattern in the stress scores over time. Requests for critical incident stress intervention were uncommon. The need for intervention may not be as great as generally is assumed. Further randomized trials, ideally multicenter studies, are indicated.

  15. CONTROL TECHNIQUES FOR VARIOUS BIPOLAR PWM STRATEGIES OF THREE PHASE FIVE LEVEL CASCADED INVERTER

    Directory of Open Access Journals (Sweden)

    C. R. BALAMURUGAN

    2015-07-01

    Full Text Available This paper presents different types of bipolar Pulse Width Modulation (PWM strategies for the chosen Cascaded MultiLevel Inverter (CMLI. The main purpose of MLI is to use power semiconductor devices of lower voltage ratings to realize high voltage levels at inverter output. Due to their ability to obtain refined output voltage waveforms, reduced Total Harmonic Distortion (THD and reduced EMI problems by reducing the switching dv/dt. In this paper, a three phase CMLI is controlled with Sinusoidal PWM strategy with Phase Disposition PWM (PDPWM, Phase Opposition and Disposition PWM (PODPWM, Alternative Phase Opposition and Disposition PWM (APODPWM, Phase Shift PWM (PSPWM and hybrid modulation strategy and the variation of THD in their outputs are observed by varying the modulation index. Simulations are performed using MATLAB-SIMULINK. It is observed that APODPWM and PSPWM provide output with relatively low distortion. It is also seen that PS, APOD and hybrid PWM are found to perform better since they provide relatively higher fundamental RMS output voltage. From hardware results it is seen that POD PWM provides output with relatively low distortion. It is also observed that PSPWM is found to perform better since it provide relatively higher fundamental RMS output voltage.

  16. Diabetes Support Groups Improve Patient’s Compliance and Control Blood Glucose Levels

    Directory of Open Access Journals (Sweden)

    Zamrotul Izzah

    2013-09-01

    Full Text Available Providing information is not enough to improve diabetic patient’s compliance and achieve goals of therapy. Patient’s good awareness as well as emotional and social supports from family and community may play an important role to improve their compliance and clinical outcomes. Therefore, diabetes support groups were developed and each support group consisted of two pharmacists, two nurses, diabetic patients and their family members. A total of 70 type 2 diabetic patient’s were enrolled and randomized into support group 1 and support group 2. Patients in the group 1 received information leaflets only, while patient in the group 2 received pharmacist counselling and information leaflets at each meeting. Patient’s awareness of diabetes and compliance with medications were assessed by a short questionnaire at baseline and final follow-up. Blood glucose and cholesterol levels were also evaluated in both groups. At the end of study, the overall patient’s awareness and compliance improved by 61.5%. The random and fasting blood glucose levels decreased over than 30% in the group 2 and around 14% in the group 1. This study reveals that collaboration between health care professionals and community in the diabetes support group might help diabetic patients to increase their knowledge and compliance with the diabetes therapy as well as glycaemic control.

  17. Interaural level difference-dependent gain control and synaptic scaling underlying binaural computation.

    Science.gov (United States)

    Xiong, Xiaorui R; Liang, Feixue; Li, Haifu; Mesik, Lukas; Zhang, Ke K; Polley, Daniel B; Tao, Huizhong W; Xiao, Zhongju; Zhang, Li I

    2013-08-21

    Binaural integration in the central nucleus of inferior colliculus (ICC) plays a critical role in sound localization. However, its arithmetic nature and underlying synaptic mechanisms remain unclear. Here, we showed in mouse ICC neurons that the contralateral dominance is created by a "push-pull"-like mechanism, with contralaterally dominant excitation and more bilaterally balanced inhibition. Importantly, binaural spiking response is generated apparently from an ipsilaterally mediated scaling of contralateral response, leaving frequency tuning unchanged. This scaling effect is attributed to a divisive attenuation of contralaterally evoked synaptic excitation onto ICC neurons with their inhibition largely unaffected. Thus, a gain control mediates the linear transformation from monaural to binaural spike responses. The gain value is modulated by interaural level difference (ILD) primarily through scaling excitation to different levels. The ILD-dependent synaptic scaling and gain adjustment allow ICC neurons to dynamically encode interaural sound localization cues while maintaining an invariant representation of other independent sound attributes. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Differentiated availability of geochemical mercury pools controls methylmercury levels in estuarine sediment and biota.

    Science.gov (United States)

    Jonsson, Sofi; Skyllberg, Ulf; Nilsson, Mats B; Lundberg, Erik; Andersson, Agneta; Björn, Erik

    2014-08-20

    Neurotoxic methylmercury (MeHg) formed from inorganic divalent mercury (Hg(II)) accumulates in aquatic biota and remains at high levels worldwide. It is poorly understood to what extent different geochemical Hg pools contribute to these levels. Here we report quantitative data on MeHg formation and bioaccumulation, in mesocosm water-sediment model ecosystems, using five Hg(II) and MeHg isotope tracers simulating recent Hg inputs to the water phase and Hg stored in sediment as bound to natural organic matter or as metacinnabar. Calculations for an estuarine ecosystem suggest that the chemical speciation of Hg(II) solid/adsorbed phases control the sediment Hg pool's contribution to MeHg, but that input of MeHg from terrestrial and atmospheric sources bioaccumulates to a substantially greater extent than MeHg formed in situ in sediment. Our findings emphasize the importance of MeHg loadings from catchment runoff to MeHg content in estuarine biota and we suggest that this contribution has been underestimated.

  19. CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls.

    Science.gov (United States)

    Herbert, Megan K; Eeftens, Jorine M; Aerts, Marjolein B; Esselink, Rianne A J; Bloem, Bastiaan R; Kuiperij, H Bea; Verbeek, Marcel M

    2014-01-01

    Differential diagnosis between Parkinson's disease (PD) and multiple system atrophy (MSA) is difficult, particularly at early disease stages, but is important for therapeutic management. The protein DJ-1 is implicated in the pathology of PD but little is known about its involvement in MSA. We aimed to determine the diagnostic value of CSF DJ-1 and tau proteins for discriminating PD and MSA. DJ-1 and total tau levels were quantified in the CSF of 43 PD patients, 23 MSA patients and 30 non-neurological controls matched for age and gender. Patients were part of a study with a 3-year prospective design with extended case-review follow-up of up to 9 years, ensuring maximum accuracy of the clinical diagnosis. Our results showed that CSF DJ-1 levels could distinguish MSA from PD with a 78% sensitivity and 78% specificity (AUC = 0.84). The combination of DJ-1 and tau proteins significantly improved this discrimination to 82% sensitivity and 81% specificity to identify MSA from PD (AUC = 0.92). Our results highlight the potential benefits of a combination of DJ-1 and total tau as biomarkers for differential diagnosis of MSA and PD.

  20. Neighborhood level risk factors for type 1 diabetes in youth: the SEARCH case-control study

    Directory of Open Access Journals (Sweden)

    Liese Angela D

    2012-01-01

    Full Text Available Abstract Background European ecologic studies suggest higher socioeconomic status is associated with higher incidence of type 1 diabetes. Using data from a case-control study of diabetes among racially/ethnically diverse youth in the United States (U.S., we aimed to evaluate the independent impact of neighborhood characteristics on type 1 diabetes risk. Data were available for 507 youth with type 1 diabetes and 208 healthy controls aged 10-22 years recruited in South Carolina and Colorado in 2003-2006. Home addresses were used to identify Census tracts of residence. Neighborhood-level variables were obtained from 2000 U.S. Census. Multivariate generalized linear mixed models were applied. Results Controlling for individual risk factors (age, gender, race/ethnicity, infant feeding, birth weight, maternal age, number of household residents, parental education, income, state, higher neighborhood household income (p = 0.005, proportion of population in managerial jobs (p = 0.02, with at least high school education (p = 0.005, working outside the county (p = 0.04 and vehicle ownership (p = 0.03 were each independently associated with increased odds of type 1 diabetes. Conversely, higher percent minority population (p = 0.0003, income from social security (p = 0.002, proportion of crowded households (0.0497 and poverty (p = 0.008 were associated with a decreased odds. Conclusions Our study suggests that neighborhood characteristics related to greater affluence, occupation, and education are associated with higher type 1 diabetes risk. Further research is needed to understand mechanisms underlying the influence of neighborhood context.

  1. Population-level effects of automated smoking cessation help programs: a randomized controlled trial.

    Science.gov (United States)

    Borland, Ron; Balmford, James; Benda, Peter

    2013-03-01

    To test the population impact of offering automated smoking cessation interventions via the internet and/or by mobile phone. Pragmatic randomized controlled trial with five conditions: offer of (i) minimal intervention control; (ii) QuitCoach personalized tailored internet-delivered advice program; (iii) onQ, an interactive automated text-messaging program; (iv) an integration of both QuitCoach and onQ; and (v) a choice of either alone or the combined program. Australia, via a mix of internet and telephone contacts. A total of 3530 smokers or recent quitters recruited from those interested in quitting, and seeking self-help resources (n = 1335) or cold-contacted from internet panels (n = 2195). The primary outcome was self-report of 6 months sustained abstinence at 7 months post-recruitment. Only 42.5% of those offered one of the interventions took it up to a minimal level. The intervention groups combined had a non-significantly higher 6-month sustained abstinence rate than the control [odds ratio (OR) = 1.48; 95% confidence interval (CI): 0.98-2.24] (missing cases treated as smokers), with no differences between the interventions. Among those who used an intervention, there was a significant overall increase in abstinence (OR = 1.95; CI: 1.04-3.67), but not clearly so when analysing only cases with reported outcomes. Success rates were greater among those recruited after seeking information compared to those cold-contacted. Smokers interested in quitting who were assigned randomly to an offer of either the QuitCoach internet-based support program and/or the interactive automated text-messaging program had non-significantly greater odds of quitting for at least 6 months than those randomized to an offer of a simple information website. © 2012 The Authors, Addiction © 2012 Society for the Study of Addiction.

  2. Plate tectonic controls on atmospheric CO2 levels since the Triassic.

    Science.gov (United States)

    Van Der Meer, Douwe G; Zeebe, Richard E; van Hinsbergen, Douwe J J; Sluijs, Appy; Spakman, Wim; Torsvik, Trond H

    2014-03-25

    Climate trends on timescales of 10s to 100s of millions of years are controlled by changes in solar luminosity, continent distribution, and atmosphere composition. Plate tectonics affect geography, but also atmosphere composition through volcanic degassing of CO2 at subduction zones and midocean ridges. So far, such degassing estimates were based on reconstructions of ocean floor production for the last 150 My and indirectly, through sea level inversion before 150 My. Here we quantitatively estimate CO2 degassing by reconstructing lithosphere subduction evolution, using recent advances in combining global plate reconstructions and present-day structure of the mantle. First, we estimate that since the Triassic (250-200 My) until the present, the total paleosubduction-zone length reached up to ∼200% of the present-day value. Comparing our subduction-zone lengths with previously reconstructed ocean-crust production rates over the past 140 My suggests average global subduction rates have been constant, ∼6 cm/y: Higher ocean-crust production is associated with longer total subduction length. We compute a strontium isotope record based on subduction-zone length, which agrees well with geological records supporting the validity of our approach: The total subduction-zone length is proportional to the summed arc and ridge volcanic CO2 production and thereby to global volcanic degassing at plate boundaries. We therefore use our degassing curve as input for the GEOCARBSULF model to estimate atmospheric CO2 levels since the Triassic. Our calculated CO2 levels for the mid Mesozoic differ from previous modeling results and are more consistent with available proxy data.

  3. Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

    Directory of Open Access Journals (Sweden)

    Lea SR

    2016-09-01

    Full Text Available Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester, NHS Foundation Trust, Manchester, UK; 2Novartis Pharma AG, Postfach, Basel, Switzerland; 3Respiratory Diseases, Novartis Institute for Biomedical Research, Horsham, West Sussex, UK *These authors contributed equally to this work Background: Increased pulmonary ceramide levels are suggested to play a causative role in lung diseases including COPD. Neutral sphingomyelinase-2 (nSMase-2 and acid SMase (aSMase, which hydrolyze sphingomyelin to produce ceramide, are activated by a range of cellular stresses, including inflammatory cytokines and pathogens, but notably cigarette smoke appears to only activate nSMase-2. Our primary objective was to investigate nSMase-2 and aSMase protein localization and quantification in lung tissue from nonsmokers (NS, smokers (S, and COPD patients. In addition, various ceramide species (C16, C18, and C20 were measured in alveolar macrophages from COPD patients versus controls. Materials and methods: Patients undergoing surgical resection for suspected or confirmed lung cancer were recruited, and nSMase-2 and aSMase protein was investigated in different areas of lung tissue (small airways, alveolar walls, subepithelium, and alveolar macrophages by immunohistochemistry. Ceramide species were measured in alveolar macrophages from COPD patients and controls by mass spectrometry. Results: nSMase-2 and aSMase were detected in the majority of small airways. There was a significant increase in nSMase-2 immunoreactivity in alveolar macrophages from COPD patients (54% compared with NS (31.7% (P<0.05, and in aSMase immunoreactivity in COPD (68.2% and S (69.5% alveolar macrophages compared with NS (52.4% (P

  4. Fractional Order PID Controller Design for Level Control of Three Tank System Based on Improved Cuckoo Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    Meysam Gheisarnezhad

    2015-01-01

    Full Text Available Fractional-order PID (FOPID controller is a generalization of standard PID controller using fractional calculus. Compared with the Standard PID controller, two adjustable variables “differential order” and “integral order” are added to the PID controller.Three tank system is a nonlinear multivariable process that is a good prototype of chemical industrial processes. Cuckoo Optimization Algorithm (COA, that was recently introduced has shown its good performance in optimization problems. In this study, Improved Cuckoo Optimization Algorithm (ICOA has been presented. The aim of the paper is to compare different controllers tuned with a Improved Cuckoo Optimization Algorithm (ICOA for Three Tank System. In order to compare the performance of the optimized FOPID controller with other controllers, Genetic Algorithm(GA, Particle swarm optimization (PSO, Cuckoo Optimization Algorithm (COA and Imperialist Competitive Algorithm (ICA.

  5. Comparison of Serum Zinc and Copper levels in Children and adolescents with Intractable and Controlled Epilepsy

    Directory of Open Access Journals (Sweden)

    Zeynab KHERADMAND

    2014-07-01

    Full Text Available How to Cite This Article: Kheradmand Z, Yarali B, Zare A, Pourpak Z, Shams S, Ashrafi MR. Comparison of Serum Zinc and Copper levels in Children and adolescents with Intractable and Controlled Epilepsy. Iran J Child Neurol. 2014; 8(3:49-54. AbstractObjectiveTrace elements such as zinc and copper have physiological effects on neuronal excitability that may play a role in the etiology of intractable epilepsy. This topic has been rarely discussed in Iranian epileptic patients.This study with the analysis of serum zinc and copper levels of children and adolescents with intractable and controlled epilepsy may identifies the potential role of these two trace elements in the development of epilepsy and intractabilityto antiepileptic drug treatment. Materials & MethodsSeventy patients between the ages of 6 months to 15 years that referred to Children’s Medical Center with the diagnosis of epilepsy, either controlled or intractable to treatment enrolled in the study. After informed parental consent the levels of serum zinc and copper were measured with atomic absorptionspectrophotometer and analyzed with SPSS version 11.Results35 patients were enrolled in each group of intractable (IE and controlled epilepsy (CE. 71.45% of the IE and 25.72% of the CE group had zinc deficiency that was statistically significant. 48.58% of the IE and 45.72 of the CE group were copper deficient, which was not statistically significant.ConclusionOur findings showed significant low serum zinc levels of patients with intractable epilepsy in comparison with controlled epilepsy group. We recommend that serum zinc level may play a role in the etiology of epilepsy and intractable epilepsy therefore its measurement and prescription may be regarded in the treatment of intractable epilepsy.ReferencesMikati MA. Seizures in childhood. In: Kliegman RM, Stanton BF, Schor NF, Geme JWS, Behrman R (eds. Nelson textbook of pediatrics. 19th ed. Elsevier:Saunders; 2011. Pp

  6. Direct Power Control for Three-Phase Two-Level Voltage-Source Rectifiers Based on Extended-State Observation

    DEFF Research Database (Denmark)

    Song, Zhanfeng; Tian, Yanjun; Yan, Zhuo

    2016-01-01

    characteristic is highly dynamic behaviors, the proposed control strategy can present comparably enhanced transient performance. Furthermore, excellent steady-state power performance can also be observed when the proposed control scheme is adopted. In addition, another attractive feature lies in its robust......This paper proposed a direct power control strategy for three-phase two-level voltage-source rectifiers based on extended-state observation. Active and reactive powers are directly regulated in the stationary reference frame. Similar to the family of predictive controllers whose inherent...... control strategy, the vector-oriented control scheme and the proposed strategy, which demonstrate the superiority of the proposed scheme....

  7. Anxiety and depression levels in prepubertal obese children: a case-control study

    Directory of Open Access Journals (Sweden)

    Esposito M

    2014-10-01

    depressive symptoms, the Children Depression Inventory (CDI and the Italian Self-Administered Psychiatric Scales for Children and Adolescents (SAFA were administered. The control group consisted of 273 healthy children (129 males and 144 females (mean age 9.1±1.8 years, enrolled in schools within the Campania region of Italy. Results: No significant differences between the two study groups were found for age (8.9±1.23 years in the obese sample and 9.1±1.8 years in the control group (P=0.228 or sex (ratio male/female: 69/79 in the obese group versus 129/144 in the control group (P=0.983. Obviously, significant difference was found for the BMI z-score (2.46±0.31 in the obese group vs 0.73±0.51 in the control group (P<0.001. The obese subjects showed significant higher level of depressive symptoms (CDI total score (16.82±7.73 vs 8.2±2.9 (P<0.001 and anxiety (SAFA – Anxiety [SAFA-A] scale score (58.71±11.84 vs 27.75±11.5 (P<0.001 compared with the control group. Moreover, the Pearson’s correlation analysis showed a significantly positive relationship between the BMI z-score and both the CDI (r=0.677; P<0.001 and SAFA-A scores (r=0.591; P<0.001. Conclusion: Our findings highlighted the importance of assessing the presence of internalizing problems, such as anxiety and depression, in the common management of childhood obesity. Keywords: childhood obesity, internalizing problems, SAFA, CDI

  8. Comparative case-control study of homocysteine, vitamin B12, and folic acid levels in patients with epilepsy.

    Science.gov (United States)

    Pulido Fontes, L; Pulido Fontes, M; Quesada Jiménez, P; Muruzabal Pérez, J; Mendioroz Iriarte, M

    2017-09-01

    Increased blood homocysteine levels are a known cardiovascular risk factor. Epileptic patients on long-term treatment with antiepileptic drugs may present higher homocysteine levels and, consequently, a potential increase in cardiovascular risk. We conducted an observational case-control study to compare plasma levels of homocysteine, folic acid, and vitamin B12. Our study included a total of 88 subjects: 52 patients with epilepsy and 36 controls. Epileptic patients showed higher homocysteine levels (P=.084) and lower levels of folic acid (P<.05). Homocysteine levels should be monitored in epileptic patients on long-term treatment with antiepileptic drugs. We suggest starting specific treatment in patients with high homocysteine levels. Copyright © 2016 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Verification of a level-3 diesel emissions control strategy for transport refrigeration units

    Science.gov (United States)

    Shewalla, Umesh

    Transport Refrigeration Units (TRUs) are refrigeration systems used to control the environment of temperature sensitive products while they are being transported from one place to another in trucks, trailers or shipping containers. The TRUs typically use an internal combustion engine to power the compressor of the refrigeration unit. In the United States TRUs are most commonly powered by diesel engines which vary from 9 to 40 horsepower. TRUs are capable of both heating and cooling. The TRU engines are relatively small, inexpensive and do not use emissions reduction techniques such as exhaust gas recirculation (EGR). A significant number of these engines operate in highly populated areas like distribution centers, truck stops, and other facilities which make them one of the potential causes for health risks to the people who live and work nearby. Diesel particulate matter (PM) is known for its adverse effects on both human beings and the environment. Considering these effects, regulatory bodies have imposed limitations on the PM emissions from a TRU engine. The objective of this study was to measure and analyze the regulated emissions from a TRU engine under both engine out and particulate filter system out conditions during pre-durability (when the filter system was new) and post-durability test (after the filter system was subjected to 1000 hours in-field trial). The verification program was performed by the Center for Alternative Fuel, Engines and Emissions (CAFEE) at West Virginia University (WVU). In this program, a catalyzed silicon carbide (SiC) diesel particulate filter (DPF) was evaluated and verified as a Level-3 Verified Diesel Emissions Control Strategy (VDECS) (. 85% PM reduction) under California Air Resources Board (CARB) regulations 2702 [1]. The emissions result showed that the filter system reduced diesel PM by a percentage of 96 +/- 1 over ISO 8178-C1 [2] cycle and 92 +/- 5 over EPA TRU [3] cycle, qualifying as a Level 3 VDECS. The percentage

  10. Output Feedback Dissipation Control for the Power-Level of Modular High-Temperature Gas-Cooled Reactors

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2011-11-01

    Full Text Available Because of its strong inherent safety features and the high outlet temperature, the modular high temperature gas-cooled nuclear reactor (MHTGR is the chosen technology for a new generation of nuclear power plants. Such power plants are being considered for industrial applications with a wide range of power levels, thus power-level regulation is very important for their efficient and stable operation. Exploiting the large scale asymptotic closed-loop stability provided by nonlinear controllers, a nonlinear power-level regulator is presented in this paper that is based upon both the techniques of feedback dissipation and well-established backstepping. The virtue of this control strategy, i.e., the ability of globally asymptotic stabilization, is that it takes advantage of the inherent zero-state detectability property of the MHTGR dynamics. Moreover, this newly built power-level regulator is also robust towards modeling uncertainty in the control rod dynamics. If modeling uncertainty of the control rod dynamics is small enough to be omitted, then this control law can be simplified to a classical proportional feedback controller. The comparison of the control performance between the newly-built power controller and the simplified controller is also given through numerical study and theoretical analysis.

  11. Efficacy of Using the Japanese Version of the Asthma Control Test for Determing the Level of Asthma Control in Clinical Settings

    Directory of Open Access Journals (Sweden)

    Takashi Hasegawa

    2012-01-01

    Conclusions: Our study, the first large-scale investigation of the efficacy of the J-ACT, determined that this evaluation tool is highly efficacious in establishing the level of asthma control. However, the determination of accurate cutpoints for the J-ACT will require more clear definitions of asthma control in future prospective studies.

  12. Study of Adiponectin Level in Diabetic Adolescent Girls in Relation to Glycemic Control and Complication of Diabetes

    Directory of Open Access Journals (Sweden)

    Soha M. Abd El Dayem

    2015-10-01

    CONCLUSION: Serum adiponectin level is high in adolescent type 1 diabetic girls. It can be used as a predictor of diabetes complications rather than a sensitive biochemical marker for glycemic control.

  13. A multilevel analysis of the demands--control model: is stress at work determined by factors at the group level or the individual level?

    Science.gov (United States)

    Van Yperen, N W; Snijders, T A

    2000-01-01

    This study explored the extent to which negative health-related outcomes are associated with differences between work groups and with differences between individuals within work groups using R.A. Karasek's (1979) demands-control model. The sample consisted of 260 employees in 31 working groups of a national bank in the Netherlands. Results suggest that job demands and job control should be conceptualized as having both group- and individual-level foundations. Support for Karasek's demands-control model was found only when these variables were split into the 2 parts, reflecting shared perceptions and employees' subjective assessment, respectively. One of the most appealing practical implications is that absence rates among homogeneous work groups can be reduced by enhancing actual control on the job.

  14. Using the decision ladder to understand road user decision making at actively controlled rail level crossings.

    Science.gov (United States)

    Mulvihill, Christine M; Salmon, Paul M; Beanland, Vanessa; Lenné, Michael G; Read, Gemma J M; Walker, Guy H; Stanton, Neville A

    2016-09-01

    Rail level crossings (RLXs) represent a key strategic risk for railways worldwide. Despite enforcement and engineering countermeasures, user behaviour at RLXs can often confound expectations and erode safety. Research in this area is limited by a relative absence of insights into actual decision making processes and a focus on only a subset of road user types. One-hundred and sixty-six road users (drivers, motorcyclists, cyclists and pedestrians) completed a diary entry for each of 457 naturalistic encounters with RLXs when a train was approaching. The final eligible sample comprised 94 participants and 248 encounters at actively controlled crossings where a violation of the active warnings was possible. The diary incorporated Critical Decision Method probe questions, which enabled user responses to be mapped onto Rasmussen's decision ladder. Twelve percent of crossing events were non-compliant. The underlying decision making was compared to compliant events and a reference decision model to reveal important differences in the structure and type of decision making within and between road user groups. The findings show that engineering countermeasures intended to improve decision making (e.g. flashing lights), may have the opposite effect for some users because the system permits a high level of flexibility for circumvention. Non-motorised users were more likely to access information outside of the warning signals because of their ability to achieve greater proximity to the train tracks and the train itself. The major conundrum in resolving these issues is whether to restrict the amount of time and information available to users so that it cannot be used for circumventing the system or provide more information to help users make safe decisions.

  15. Tight interconnection and multi-level control of Arabidopsis MYB44 in MAPK cascade signalling.

    Science.gov (United States)

    Persak, Helene; Pitzschke, Andrea

    2013-01-01

    Abiotic stress poses a huge, ever-increasing problem to plants and agriculture. The dissection of signalling pathways mediating stress tolerance is a prerequisite to develop more resistant plant species. Mitogen-activated protein kinase (MAPK) cascades are universal signalling modules. In Arabidopsis, the MAPK MPK3 and its upstream regulator MAPK kinase MKK4 initiate the adaptation response to numerous abiotic and biotic stresses. Yet, molecular steps directly linked with MKK4-MPK3 activation are largely unknown. Starting with a yeast-two-hybrid screen for interacting partners of MKK4, we identified a transcription factor, MYB44. MYB44 is controlled at multiple levels by and strongly inter-connected with MAPK signalling. As we had shown earlier, stress-induced expression of the MYB44 gene is regulated by a MPK3-targeted bZIP transcription factor VIP1. At the protein level, MYB44 interacts with MPK3 in vivo. MYB44 is phosphorylated by MPK3 in vitro at a single residue, Ser145. Although replacement of Ser145 by a non-phosphorylatable (S145A) or phosphomimetic (S145D) residue did not alter MYB44 subcellular localisation, dimerization behaviour nor DNA-binding characteristics, abiotic stress tolerance tests in stable transgenic Arabidopsis plants clearly related S145 phosphorylation to MYB44 function: Compared to Arabidopsis wild type plants, MYB44 overexpressing lines exhibit an enhanced tolerance to osmotic stress and are slightly more sensitive to abscisic acid. Interestingly, overexpression of the S145A variant revealed that impaired phosphorylation does not render the MYB44 protein non-functional. Instead, S145A lines are highly sensitive to abiotic stress, and thereby remarkably similar to mpk3-deficient plants. Its in vivo interaction with the nuclear sub-pools of both MPK3 and MKK4 renders MYB44 the first plant transcription factor to have a second function as putative MAPK cascade scaffolding protein.

  16. Effect of high-dose dexamethasone on perioperative lactate levels and glucose control : a randomized controlled trial

    NARCIS (Netherlands)

    Ottens, Thomas H.; Nijsten, Maarten W. N.; Hofland, Jan; Dieleman, Jan M.; Hoekstra, Miriam; van Dijk, Diederik; van der Maaten, Joost M. A. A.

    2015-01-01

    Introduction: Blood lactate levels are increasingly used to monitor patients. Steroids are frequently administered to critically ill patients. However, the effect of steroids on lactate levels has not been adequately investigated. We studied the effect of a single intraoperative high dose of

  17. Entropy as a measure of the noise extent in a two-level quantum feedback controlled system

    Institute of Scientific and Technical Information of China (English)

    Wang Tao-Bo; Fang Mao-Fa; Hu Yao-Hua

    2007-01-01

    By introducing the von Neumann entropy as a measure of the extent of noise, this paper discusses the entropy evolution in a two-level quantum feedback controlled system. The results show that the feedback control can induce the reduction of the degree of noise, and different control schemes exhibit different noise controlling ability, the extent of the reduction also related with the position of the target state on the Bloch sphere. It is shown that the evolution of entropy can provide a real time noise observation and a systematic guideline to make reasonable choice of control strategy.

  18. Quality assurance plan for the High Level Controller for the CBMS Block II

    Energy Technology Data Exchange (ETDEWEB)

    Reid, R.W.; Robbins, I.F.; Stewart, K.A.; Terry, C.L.; Whitaker, R.A.; Wolf, D.A.; Zager, J.C.

    1997-09-01

    This document establishes the software Quality Assurance Plan (QAP) for the High Level Controller for the Chemical and Biological Mass Spectrometer Block II (HLC/CBMS-II) project activities under the Computing, Robotics, and Education (CRE) Directorate management. It defines the requirements and assigns responsibilities for ensuring, with a high degree of confidence, that project objectives will be achieved as planned. The CBMS Program was awarded to ORNL by the US Army Chemical and Biological Defense command, Aberdeen Proving Ground, Maryland, to design the next version (Block II) mass spectrometer for the detection and identification of chemical and biological warfare agents, to fabricate four engineering prototypes, and to construct eight preproduction units. Section 1 of this document provides an introduction to the HLC/CBMS-II project QAP. Sections 2 and 3 describe the specific aspects of quality assurance as applicable to the project. Section 4 reviews the project approach to risk management. The Risk Management Matrix given in Appendix A is a tool to assess, prioritize, and prevent problems before they occur; therefore, the matrix will be reviewed and revised on a periodic basis. Appendix B shows the quality assurance criteria of the DOE Order 5700.6C and their applicability to this project.

  19. Transgenic resistance confers effective field level control of bacterial spot disease in tomato.

    Directory of Open Access Journals (Sweden)

    Diana M Horvath

    Full Text Available We investigated whether lines of transgenic tomato (Solanum lycopersicum expressing the Bs2 resistance gene from pepper, a close relative of tomato, demonstrate improved resistance to bacterial spot disease caused by Xanthomonas species in replicated multi-year field trials under commercial type growing conditions. We report that the presence of the Bs2 gene in the highly susceptible VF 36 background reduced disease to extremely low levels, and VF 36-Bs2 plants displayed the lowest disease severity amongst all tomato varieties tested, including commercial and breeding lines with host resistance. Yields of marketable fruit from transgenic lines were typically 2.5 times that of the non-transformed parent line, but varied between 1.5 and 11.5 fold depending on weather conditions and disease pressure. Trials were conducted without application of any copper-based bactericides, presently in wide use despite negative impacts on the environment. This is the first demonstration of effective field resistance in a transgenic genotype based on a plant R gene and provides an opportunity for control of a devastating pathogen while eliminating ineffective copper pesticides.

  20. Common software for controlling and monitoring the upgraded CMS Level-1 trigger

    CERN Document Server

    Codispoti, Giuseppe

    2017-01-01

    The Large Hadron Collider restarted in 2015 with a higher centre-of-mass energy of 13 TeV. The instantaneous luminosity is expected to increase significantly in the coming years. An upgraded Level-1 trigger system was deployed in the CMS experiment in order to maintain the same efficiencies for searches and precision measurements as those achieved in 2012. This system must be controlled and monitored coherently through software, with high operational efficiency.The legacy system was composed of a large number of custom data processor boards; correspondingly, only a small fraction of the software was common between the different subsystems. The upgraded system is composed of a set of general purpose boards, that follow the MicroTCA specification, and transmit data over optical links, resulting in a more homogeneous system. The associated software is based on generic components corresponding to the firmware blocks that are shared across different cards, regardless of the role that the card plays in the system. ...

  1. Controlled levels of canonical Wnt signaling are required for neural crest migration.

    Science.gov (United States)

    Maj, Ewa; Künneke, Lutz; Loresch, Elisabeth; Grund, Anita; Melchert, Juliane; Pieler, Tomas; Aspelmeier, Timo; Borchers, Annette

    2016-09-01

    Canonical Wnt signaling plays a dominant role in the development of the neural crest (NC), a highly migratory cell population that generates a vast array of cell types. Canonical Wnt signaling is required for NC induction as well as differentiation, however its role in NC migration remains largely unknown. Analyzing nuclear localization of β-catenin as readout for canonical Wnt activity, we detect nuclear β-catenin in premigratory but not migratory Xenopus NC cells suggesting that canonical Wnt activity has to decrease to basal levels to enable NC migration. To define a possible function of canonical Wnt signaling in Xenopus NC migration, canonical Wnt signaling was modulated at different time points after NC induction. This was accomplished using either chemical modulators affecting β-catenin stability or inducible glucocorticoid fusion constructs of Lef/Tcf transcription factors. In vivo analysis of NC migration by whole mount in situ hybridization demonstrates that ectopic activation of canonical Wnt signaling inhibits cranial NC migration. Further, NC transplantation experiments confirm that this effect is tissue-autonomous. In addition, live-cell imaging in combination with biophysical data analysis of explanted NC cells confirms the in vivo findings and demonstrates that modulation of canonical Wnt signaling affects the ability of NC cells to perform single cell migration. Thus, our data support the hypothesis that canonical Wnt signaling needs to be tightly controlled to enable migration of NC cells.

  2. Multiple levels of bilingual language control: evidence from language intrusions in reading aloud.

    Science.gov (United States)

    Gollan, Tamar H; Schotter, Elizabeth R; Gomez, Joanne; Murillo, Mayra; Rayner, Keith

    2014-02-01

    Bilinguals rarely produce words in an unintended language. However, we induced such intrusion errors (e.g., saying el instead of he) in 32 Spanish-English bilinguals who read aloud single-language (English or Spanish) and mixed-language (haphazard mix of English and Spanish) paragraphs with English or Spanish word order. These bilinguals produced language intrusions almost exclusively in mixed-language paragraphs, and most often when attempting to produce dominant-language targets (accent-only errors also exhibited reversed language-dominance effects). Most intrusion errors occurred for function words, especially when they were not from the language that determined the word order in the paragraph. Eye movements showed that fixating a word in the nontarget language increased intrusion errors only for function words. Together, these results imply multiple mechanisms of language control, including (a) inhibition of the dominant language at both lexical and sublexical processing levels, (b) special retrieval mechanisms for function words in mixed-language utterances, and (c) attentional monitoring of the target word for its match with the intended language.

  3. CA-LOD: Collision Avoidance Level of Detail for Scalable, Controllable Crowds

    Science.gov (United States)

    Paris, Sébastien; Gerdelan, Anton; O'Sullivan, Carol

    The new wave of computer-driven entertainment technology throws audiences and game players into massive virtual worlds where entire cities are rendered in real time. Computer animated characters run through inner-city streets teeming with pedestrians, all fully rendered with 3D graphics, animations, particle effects and linked to 3D sound effects to produce more realistic and immersive computer-hosted entertainment experiences than ever before. Computing all of this detail at once is enormously computationally expensive, and game designers as a rule, have sacrificed the behavioural realism in favour of better graphics. In this paper we propose a new Collision Avoidance Level of Detail (CA-LOD) algorithm that allows games to support huge crowds in real time with the appearance of more intelligent behaviour. We propose two collision avoidance models used for two different CA-LODs: a fuzzy steering focusing on the performances, and a geometric steering to obtain the best realism. Mixing these approaches allows to obtain thousands of autonomous characters in real time, resulting in a scalable but still controllable crowd.

  4. Comparison of PI and PR current controllers applied on two-level VSC-HVDC transmission system

    DEFF Research Database (Denmark)

    Manoloiu, A.; Pereria, H.A.; Teodorescu, Remus;

    2015-01-01

    This paper analyzes differences between αβ and dq reference frames regarding the control of two-level VSC-HVDC current loop and dc-link voltage outer loop. In the first part, voltage feedforward effect is considered with PI and PR controllers. In the second part, the feedforward effect is removed...

  5. Absolute phase control of spectra effects in a two-level medium driven by two-color ultrashort laser pulses

    Energy Technology Data Exchange (ETDEWEB)

    Xia Keyu [State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate University of Chinese Academy of Sciences (China); Niu Yueping [State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate University of Chinese Academy of Sciences (China); Li Chunfang [Department of Physics, Shanghai University, Shanghai 200436 (China); Gong Shangqing [CCAST (World Laboratory), PO Box 8730, Beijing 100080 (China) and State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)]. E-mail: sqgong@siom.ac.cn

    2007-01-22

    Using a {omega}-3{omega} combination scenario, we investigate the absolute phase control of the spectra effects for ultrashort laser pulses propagating in a two-level medium. It is found that the higher spectral components can be controlled by the absolute phases. In particular, different absolute phase combinations can lead to the buildup or split of the even harmonics.

  6. SERUM PROLACTIN LEVEL IN ACNE PATIENTS VERSUS CONTROL GROUP: STUDY ON 14 TO 35 YEARS OLD WOMEN

    Directory of Open Access Journals (Sweden)

    G FAGHIHI

    2002-03-01

    Full Text Available Introduction. Androgens have a main role in acne pathogenesis. The interaction between prolactin and androgens generate the hypothesis of prolactin role in acne pathogenesis. Methods. In a case - control study, 71 women with modearte to severe acne were compaired with 71 healthy women about their serum prolactin levels. Results. Mean of serum prolactin level was 533 632 miu/lit in cases. Mean of serum prolactin level was 365 363 in control group (P > 0.05. There was a significant correlation between serum prolactin level and severity of acne. Discussion. Despite the non significant difference between serum prolactin level in acne patients and healthy women, thare was a significant relationship between serum prolactin level and severity of acne. It may be due to our small sample size. However, the more powerful studies is needed.

  7. Low-level RF LabVIEW{reg_sign} control software user`s manual: Version 1.0

    Energy Technology Data Exchange (ETDEWEB)

    1992-06-01

    This document details information on the low-level radio frequency (LLRF) software control package. The chapters in this manual cover the following topics: Chapter one describes the general operating principles of the LabVIEW software package, and also discusses the high-level menu panels which allow access to the individual control panels. Chapter two covers the control panels used for conditioning the cavity, and for controlling the accelerator under normal operating conditions. Chapter three provides information on the resonance detection and reflectometer calibration function, including the setup and status panels for each. Chapter four contain instructions on the use of those panels dedicated to controlling the cavity RF field. Chapter five discusses the control panels that provide setup and status information on the diagnostic monitor subsystem. Chapter six outlines those panels used to control the timing functions provided by the LLRF system. Finally, chapter seven describes the control panels used to monitor and adjust the alarm and limit functions of the system. Throughout the document, it is assumed that the reader has a general working knowledge of accelerators, high-power amplifier equipment, and low-level RF (LLRF) control systems. References are listed as footnotes as they occur in the text.

  8. Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients

    Directory of Open Access Journals (Sweden)

    Haoyong Yu

    2012-01-01

    Full Text Available CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level.

  9. Serum CA19-9 Level Associated with Metabolic Control and Pancreatic Beta Cell Function in Diabetic Patients

    Science.gov (United States)

    Yu, Haoyong; Li, Ruixia; Zhang, Lei; Chen, Haibing; Bao, Yuqian; Jia, Weiping

    2012-01-01

    CA19-9 is a tumor-associated antigen. It is also a marker of pancreatic tissue damage that might be caused by diabetes. Long-term poor glycemic control may lead to pancreatic beta cell dysfunction which is reflected by elevated serum CA19-9 level. Intracellular cholesterol accumulation leads to islet dysfunction and impaired insulin secretion which provide a new lipotoxic model. This study firstly found total cholesterol was one of the independent contributors to CA19-9. Elevated serum CA19-9 level in diabetic patients may indicate further investigations of glycemic control, pancreatic beta cell function, and total cholesterol level. PMID:22778715

  10. Health-related quality of life and risk factor control: the importance of educational level in prevention of cardiovascular diseases.

    Science.gov (United States)

    Ose, Dominik; Rochon, Justine; Campbell, Stephen M; Wensing, Michel; Freund, Tobias; van Lieshout, Jan; Längst, Gerda; Szecsenyi, Joachim; Ludt, Sabine

    2014-08-01

    This study aimed to describe and to analyse the importance of educational level for controlled risk factors and health-related quality of life (HRQoL). This observational study was conducted in nine European countries (5632 patients in 249 practices). We compared patients with a low level of education (up to 9 years) with patients with a high level of education (>9 years), with regard to controlled cardiovascular disease risk factors and HRQoL. A multilevel approach was used for statistical analysis. Patients with a low level of education were older (P controlled risk factors were revealed for blood pressure (RR) ≤ 140/90 mmHg (P = 0.039) and the sum of controlled risk factors (P = 0.027). Higher age, lower education, female gender, living as single, patient group (coronary heart disease patients) and the number of other conditions were negatively associated with HRQoL. A higher sum of controlled risk factors were positively associated with higher HRQoL in the whole sample (r = 0.0086, P control of risk factors was, the higher the HRQoL was overall as well as in both educational-level groups. © The Author 2013. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

  11. The Cool Little Kids randomised controlled trial: Population-level early prevention for anxiety disorders

    Directory of Open Access Journals (Sweden)

    Hiscock Harriet

    2011-01-01

    Full Text Available Abstract Background The World Health Organization predicts that by 2030 internalising problems (e.g. depression and anxiety will be second only to HIV/AIDS in international burden of disease. Internalising problems affect 1 in 7 school aged children, impacting on peer relations, school engagement, and later mental health, relationships and employment. The development of early childhood prevention for internalising problems is in its infancy. The current study follows two successful 'efficacy' trials of a parenting group intervention to reduce internalising disorders in temperamentally inhibited preschool children. Cool Little Kids is a population-level randomised trial to determine the impacts of systematically screening preschoolers for inhibition then offering a parenting group intervention, on child internalising problems and economic costs at school entry. Methods/Design This randomised trial will be conducted within the preschool service system, attended by more than 95% of Australian children in the year before starting school. In early 2011, preschool services in four local government areas in Melbourne, Australia, will distribute the screening tool. The ≈16% (n≈500 with temperamental inhibition will enter the trial. Intervention parents will be offered Cool Little Kids, a 6-session group program in the local community, focusing on ways to develop their child's bravery skills by reducing overprotective parenting interactions. Outcomes one and two years post-baseline will comprise child internalising diagnoses and symptoms, parenting interactions, and parent wellbeing. An economic evaluation (cost-consequences framework will compare incremental differences in costs of the intervention versus control children to incremental differences in outcomes, from a societal perspective. Analyses will use the intention-to-treat principle, using logistic and linear regression models (binary and continuous outcomes respectively to compare outcomes

  12. Sliding Mode Control of Three Levels Back-To-Back VSC-HVDC System Using Space Vector Modulation

    Directory of Open Access Journals (Sweden)

    Bouafia Saber

    2014-03-01

    Full Text Available In this study, a sliding mode strategy proposed to control a three levels Back-to-Back High Voltage Direct Current (HVDC system based on the three-level voltage source converter (VSC. The voltage-balancing control of two split DC capacitors of the VSC-HVDC system is achieved using three-level space vector modulation with balancing strategy based on the effective use of the redundant switching states of the inverter voltage vectors. Finally, a complete simulation of the VSC-HVDC system validates the efficiency of the proposed strategy law. Compared to the conventional control, Sliding Mode Control scheme for the VSC-HVDC system shows the attractive advantages such as offering high tracking accuracy, fast dynamic response and good robustness.

  13. Fuzzy Logic Controlling of a Single Phase Seven-Level Grid-Connected Inverter for Photovoltaic system

    Directory of Open Access Journals (Sweden)

    Siva GanaVara Prasad P., Amrutha Veena Chandrapati, Navyata Yesodha Rao K., Lakshmi Prasanth K.

    2014-05-01

    Full Text Available This paper proposes fuzzy logic controller based a single-phase seven-level inverter for grid-connected photovoltaic systems, with a novel pulse width-modulation (PWM control scheme. Three reference signals produces from fuzzy logic controller which are identical to each other are going to compare with the amplitude of the triangular carrier signal. The inverter is capable of producing seven levels( Vab = Vdc Vab = 2Vdc/3 Vab = Vdc/3 Vab = 0 Vab = −V dc/3 Vab= − 2Vdc/3 Vab = −V dc of output-voltage levels from the dc supply voltage. The total harmonic distortion is reduces by this control strategy. The proposed system was verified through simulation.

  14. The effects of low level chlorination and chlorine dioxide on biofouling control in a once-through service water system

    Energy Technology Data Exchange (ETDEWEB)

    Garrett, W.E. Jr. [Alabama Power Co./GSC No. 8, Birmingham, AL (United States); Laylor, M.M. [Univ. of Alabama, Birmingham, AL (United States)

    1995-06-01

    Continuous chlorination has been successfully used for the control of Corbicula at a nuclear power plant located on the Chattahoochee River in southeastern Alabama, since 1986. The purpose of this study was to investigate further minimization of chlorine usage and determine if chlorine dioxide is a feasible alternative. Four continuous biocide treatments were evaluated for macro and microfouling control effectiveness, operational feasibility, and environmental acceptability. One semi-continuous chlorination treatment was also evaluated for macrofouling control effectiveness. Higher treatment residuals were possible with chlorine dioxide than with chlorination due to the river discharge limitations. At the levels tested, continuous chlorine dioxide was significantly more effective in providing both macro and microfouling control. Semi-continuous chlorination was just as effective as continuous chlorination for controlling macrofouling. The Corbicula treatment programs that were tested should all provide sufficient control for zebra mussels. Chlorine dioxide was not as cost effective as chlorination for providing macrofouling control. The semi-continuous treatment save 50% on chemical usage and will allow for the simultaneous treatment of two service water systems. Chlorite levels produced during the chlorine dioxide treatments were found to be environmentally acceptable. Levels of trihalomethanes in the chlorinated service water were less than the maximum levels allowed in drinking water.

  15. Individuals with autism have higher 8-Iso-PGF2α levels than controls, but no correlation with quantitative assay of Paraoxonase 1 serum levels.

    Science.gov (United States)

    Pop, Bianca; Niculae, Alexandru-Ștefan; Pop, Tudor Lucian; Răchișan, Andreea Liana

    2017-08-14

    Autism spectrum disorder (ASD) represents a very large set of neurodevelopmental issues with diverse clinical outcomes. Various hypotheses have been put forth for the etiology of autism spectrum disorder, including issues pertaining to oxidative stress. In this study, we conducted measurements of serum 8-Iso-Prostaglanding F2 α (8-iso-PGF2α, which is the results of non-enzimatically mediated polyunsaturated fatty acid oxidation) in a population of individuals with autism and a control group of age and sex matched controls. A quantitative assay of Paraoxonase 1 (PON1) was conducted. Data regarding comorbidities, structural MRI scans, medication, intelligence quotient (IQ) and Childhood Autism Rating Scale scores (CARS) were also included in our study. Our results show that patients diagnosed with autism have higher levels of 8-iso-PGF2α than their neurotypical counterparts. Levels of this particular metabolite, however, do not correlate with quantitative serum levels of Paraoxonase 1, which has been shown to be altered in individuals with autism. Neither 8-iso-PGF2α nor quantitative levels of PON1 provide any meaningful correlation with clinical or neuroimaging data in this study group. Future research should focus on providing data regarding PON 1 phenotype, in addition to standard quantitative measurements, in relation to 8-iso-PGF2α as well as other clinical and structural brain findings.

  16. Vitamin D Levels May Fall When Women Stop Taking Birth Control

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160259.html Vitamin D Levels May Fall When Women Stop Taking ... 4, 2016 THURSDAY, Aug. 4, 2016 (HealthDay News) -- Vitamin D levels may drop after women stop using ...

  17. Edaphic controls on ecosystem-level carbon allocation in two contrasting Amazon forests

    Science.gov (United States)

    Jiménez, Eliana M.; Peñuela-Mora, María. Cristina; Sierra, Carlos A.; Lloyd, Jon; Phillips, Oliver L.; Moreno, Flavio H.; Navarrete, Diego; Prieto, Adriana; Rudas, Agustín.; Álvarez, Esteban; Quesada, Carlos A.; Grande-Ortíz, Maria Angeles; García-Abril, Antonio; Patiño, Sandra

    2014-09-01

    Studies of carbon allocation in forests provide essential information for understanding spatial and temporal differences in carbon cycling that can inform models and predict possible responses to changes in climate. Amazon forests play a particularly significant role in the global carbon balance, but there are still large uncertainties regarding abiotic controls on the rates of net primary production (NPP) and the allocation of photosynthetic products to different ecosystem components. We evaluated three different aspects of stand-level carbon allocation (biomass, NPP, and its partitioning) in two amazon forests on different soils (nutrient-rich clay soils versus nutrient-poor sandy soils) but otherwise growing under similar conditions. We found differences in carbon allocation patterns between these two forests, showing that the forest on clay soil had a higher aboveground and total biomass as well as a higher aboveground NPP than the sandy forest. However, differences between the two forest types in terms of total NPP were smaller, as a consequence of different patterns in the carbon allocation of aboveground and belowground components. The proportional allocation of NPP to new foliage was relatively similar between them. Our results of aboveground biomass increments and fine-root production suggest a possible trade-off between carbon allocation to fine roots versus aboveground compartments, as opposed to the most commonly assumed trade-off between total aboveground and belowground production. Despite these differences among forests in terms of carbon allocation, the leaf area index showed only small differences, suggesting that this index is more indicative of total NPP than its aboveground or belowground components.

  18. Learner Control over Full and Lean Computer-based Instruction under Differing Ability Levels.

    Science.gov (United States)

    Schnackenberg, Heidi L.; Sullivan, Howard J.

    2000-01-01

    Examines the effects of type of instructional control (learner control versus program control) and program mode (full versus lean) on the achievement, option use, time in the program, and attitudes of higher-ability and lower-ability university students using a computer-delivered instructional program. Discusses implications for instructional…

  19. Application of Neural network PID Controller in Constant Temperature and Constant Liquid-level System

    Institute of Scientific and Technical Information of China (English)

    Chen,Guochu; Zhang,Lin; Hao,Ninmei; Liu,Xianguang; Wang,Junhong

    2003-01-01

    Guided by the principle of neural network, an intelligent PID controller based on neural network is devised and applied to control of constant temperature and constant liquidlevel system. The experiment results show that this controller has high accuracy and strong robustness and good characters.

  20. Association of low levels of vitamin D with chronic stable angina: A prospective case-control study

    Directory of Open Access Journals (Sweden)

    Ab Hameed Raina

    2016-01-01

    Full Text Available Background: Coronary artery disease (CAD is a major cause of death and disability in developed countries. Chronic stable angina is the initial manifestation of CAD in approximately 50% of the patients. Recent evidence suggests that vitamin D is crucial for cardiovascular health. The prevalence of vitamin D deficiency in our region is 83%. A low level of vitamin D is associated with chronic stable angina. Aim: This study was aimed at supporting or refuting this hypothesis in our population. Materials and Methods: The study was a prospective case-control study. We studied 100 cases of chronic stable angina and compared them with 100 matched controls. Vitamin D deficiency was defined as <20 ng/mL, vitamin D insufficiency as 20-30 ng/mL and normal vitamin D level as 31-150 ng/mL. Results: The prevalence of vitamin D deficiency among cases and controls was 75% and 10%, respectively. 75% of the cases were vitamin D-deficient (<20 ng/mL; 12% were vitamin D-insufficient (20-30 ng/mL, and 13% had normal vitamin D levels (31-150 ng/mL. None had a toxic level of vitamin D. Among the controls, 10% were vitamin D-deficient, 33% were vitamin D-insufficient, and 57% had normal vitamin D levels. The mean vitamin level among cases and controls was 15.53 ng/mL and 40.95 ng/mL, respectively, with the difference being statistically significant (P ≤ 0.0001. There was no statistically significant relation between the disease severities, i.e., on coronary angiography (CAG with vitamin D level. Among the cases, we found that an increasing age was inversely related to vitamin D levels (P = 0.027. Conclusion: Our study indicates a correlation between vitamin D deficiency and chronic stable angina. Low levels may be an independent, potentially modifiable cardiovascular risk factor.

  1. Tertiary and secondary control levels for efficiency optimization and system damping in droop controlled dc-dc converters

    DEFF Research Database (Denmark)

    Meng, Lexuan; Dragicevic, Tomislav; Quintero, Juan Carlos Vasquez

    2015-01-01

    and applied for maintaining system stability. Hardware-in-the-loop simulations are conducted to validate the effectiveness of this method. The results show that the system efficiency is improved by using tertiary optimization control and the desired transient response is ensured with system damping secondary...

  2. Serum 25(OH Vitamin D levels is not associated with disability in multiple sclerosis patients: A case-control study.

    Directory of Open Access Journals (Sweden)

    Masoud Nikanfar

    2015-03-01

    Full Text Available It seems that serum vitamin D levels are one of the potential environmental factors affecting the severity of multiple sclerosis (MS. In this study, we aim to evaluate vitamin D levels in MS patients and healthy subjects and assess the relationship between vitamin D level and disability.In this case-control study, 168 rapid relapsing MS patients and 168 matched healthy controls were randomly included in this study. Demographic characteristics and serum vitamin D levels for patients and controls, as well as expanded disability status scale (EDSS, duration of disease and diagnostic lag for patients were evaluated. We followed up patients for 6 months and relapses were recorded.The mean serum vitamin D levels were 19.16 ± 17.37 inpatients and 25.39 ± 19.67 in controls (P = 0.560. The mean serum vitamin D levels were 12.65 ± 13.3 in patients with relapses and 22.08 ± 18.22 in patients without any relapses (P < 0.001. There was no significant correlation between EDSS score and serum vitamin D levels (r = -0.08, P = 0.280. There was a significant positive correlation between EDSS score and disease duration (r = 0.52, P < 0.001.In conclusion, vitamin D level in patients with MS was significantly lower than the healthy subjects, but no significant relationship was found between vitamin D levels and disability. Our findings did not suggest a protective role for serum vitamin D levels against disability.

  3. Saturated Adaptive Output-Feedback Power-Level Control for Modular High Temperature Gas-Cooled Reactors

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2014-11-01

    Full Text Available Small modular reactors (SMRs are those nuclear fission reactors with electrical output powers of less than 300 MWe. Due to its inherent safety features, the modular high temperature gas-cooled reactor (MHTGR has been seen as one of the best candidates for building SMR-based nuclear plants with high safety-level and economical competitive power. Power-level control is crucial in providing grid-appropriation for all types of SMRs. Usually, there exists nonlinearity, parameter uncertainty and control input saturation in the SMR-based plant dynamics. Motivated by this, a novel saturated adaptive output-feedback power-level control of the MHTGR is proposed in this paper. This newly-built control law has the virtues of having relatively neat form, of being strong adaptive to parameter uncertainty and of being able to compensate control input saturation, which are given by constructing Lyapunov functions based upon the shifted-ectropies of neutron kinetics and reactor thermal-hydraulics, giving an online tuning algorithm for the controller parameters and proposing a control input saturation compensator respectively. It is proved theoretically that input-to-state stability (ISS can be guaranteed for the corresponding closed-loop system. In order to verify the theoretical results, this new control strategy is then applied to the large-range power maneuvering control for the MHTGR of the HTR-PM plant. Numerical simulation results show not only the relationship between regulating performance and control input saturation bound but also the feasibility of applying this saturated adaptive control law practically.

  4. Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: relation to negative symptoms.

    Science.gov (United States)

    Sumiyoshi, Tomiki; Anil, A Elif; Jin, Dai; Jayathilake, Karu; Lee, Myung; Meltzer, Herbert Y

    2004-03-01

    Previous studies have suggested decreased N-methyl-D-aspartate (NMDA)-type glutamate receptor function may contribute to increased negative symptoms in patients with schizophrenia. Consistent with this hypothesis, glycine, a co-agonist at NMDA receptors, has been reported to improve negative symptoms associated with the illness. This study was performed to determine if plasma levels of glycine or its ratio to serine, a precursor of glycine, are decreased in patients with schizophrenia compared to normal control subjects or patients with major depression. We also tested the hypothesis that these amino acids were correlated with negative symptoms in subjects with schizophrenia. Plasma levels of glycine, serine, and their ratio, were compared in 144 patients with schizophrenia, 44 patients with major depression, and 49 normal control subjects. All subjects were medication-free. Psychopathology was evaluated using the Brief Psychiatric Rating Scale (BPRS). Plasma glycine levels and glycine/serine ratios were decreased in patients with schizophrenia relative to control subjects and patients with major depression. By contrast, serine levels were increased in patients with schizophrenia compared to normal subjects but not compared to major depression. Patients with major depression also had increased plasma serine levels and decreased glycine/serine ratios compared to normal controls, but glycine levels were not different from those of normal controls. In subjects with schizophrenia, glycine levels predicted the Withdrawal-Retardation score (BPRS), whereas no such correlation was found in subjects with major depression. These results provide additional evidence that decreased availability of glycine may be related to the pathophysiology of negative symptoms. The decreases in plasma glycine levels support the evidence for an abnormality in the glutamatergic system in schizophrenia, and provide additional support for efforts to improve negative symptoms by augmentation of

  5. Experimental Results of a DC Bus Voltage Level Control for a Load-Controlled Marine Current Energy Converter

    Directory of Open Access Journals (Sweden)

    Johan Forslund

    2015-05-01

    Full Text Available This paper investigates three load control methods for a  marine current energy converter using a vertical axis current  turbine (VACT mounted on a permanent magnet synchronous generator  (PMSG. The three cases are; a fixed AC load, a fixed pulse width  modulated (PWM DC load and DC bus voltage control of a DC  load. Experimental results show that the DC bus voltage control  reduces the variations of rotational speed by a factor of 3.5 at the cost  of slightly increased losses in the generator and transmission lines.  For all three cases, the tip speed ratio \\(\\lambda\\ can be kept close to  the expected \\(\\lambda_{opt}\\. The power coefficient is estimated to be  0.36 at \\(\\lambda_{opt}\\; however, for all three cases, the average  extracted power was about \\(\\sim 19\\\\%. A maximum power point  tracking (MPPT system, with or without water velocity measurement,  could increase the average extracted power.

  6. Apparatus, method and system to control accessibility of platform resources based on an integrity level

    Science.gov (United States)

    Jenkins, Chris; Pierson, Lyndon G.

    2016-10-25

    Techniques and mechanism to selectively provide resource access to a functional domain of a platform. In an embodiment, the platform includes both a report domain to monitor the functional domain and a policy domain to identify, based on such monitoring, a transition of the functional domain from a first integrity level to a second integrity level. In response to a change in integrity level, the policy domain may configure the enforcement domain to enforce against the functional domain one or more resource accessibility rules corresponding to the second integrity level. In another embodiment, the policy domain automatically initiates operations in aid of transitioning the platform from the second integrity level to a higher integrity level.

  7. Apparatus, method and system to control accessibility of platform resources based on an integrity level

    Energy Technology Data Exchange (ETDEWEB)

    Jenkins, Chris; Pierson, Lyndon G.

    2016-10-25

    Techniques and mechanism to selectively provide resource access to a functional domain of a platform. In an embodiment, the platform includes both a report domain to monitor the functional domain and a policy domain to identify, based on such monitoring, a transition of the functional domain from a first integrity level to a second integrity level. In response to a change in integrity level, the policy domain may configure the enforcement domain to enforce against the functional domain one or more resource accessibility rules corresponding to the second integrity level. In another embodiment, the policy domain automatically initiates operations in aid of transitioning the platform from the second integrity level to a higher integrity level.

  8. Representing Causality and Reasoning about Controllability of Multi-level Flow-Systems

    DEFF Research Database (Denmark)

    Heussen, Kai; Lind, Morten

    2010-01-01

    -based reasoning about control situations remains a challenge due to the entanglement of process and control systems that co-establish the intended causal structure of a process. Due to this entanglement, reasoning about such systems depends on a coherent representation of control and process. This paper explains...... modeling of controlled processes with multilevelflow models and proposes a new framework for modeling causal influence in multilevel flow models on the basis of a flow/potential analogy. The results are illustrated on examples from the domain of electric power systems....

  9. Two-Level Control for Fast Electrical Vehicle Charging Stations with Multi Flywheel Energy Storage System

    DEFF Research Database (Denmark)

    SUN, BO; Dragicevic, Tomislav; Vasquez, Juan Carlos

    2015-01-01

    This paper applies a hierarchical control for a fast charging station (FCS) composed of paralleled PWM rectifier and dedicated paralleled multiple flywheel energy storage systems (FESSs), in order to mitigate peak power shock on grid caused by sudden connection of electrical vehicle (EV) chargers....... Distributed DC-bus signaling (DBS) and method resistive virtual impedance are employed in the power coordination of grid and flywheel converters, and a centralized secondary controller generates DC voltage correction term to adjust the local voltage set point. The control system is able to realize the power...... control strategy....

  10. Sea level and turbidity controls on mangrove soil surface elevation change

    Science.gov (United States)

    Lovelock, Catherine E.; Adame, Maria Fernanda; Bennion, Vicki; Hayes, Matthew; Reef, Ruth; Santini, Nadia; Cahoon, Donald R.

    2015-02-01

    Increases in sea level are a threat to seaward fringing mangrove forests if levels of inundation exceed the physiological tolerance of the trees; however, tidal wetlands can keep pace with sea level rise if soil surface elevations can increase at the same pace as sea level rise. Sediment accretion on the soil surface and belowground production of roots are proposed to increase with increasing sea level, enabling intertidal habitats to maintain their position relative to mean sea level, but there are few tests of these predictions in mangrove forests. Here we used variation in sea level and the availability of sediments caused by seasonal and inter-annual variation in the intensity of La Nina-El Nino to assess the effects of increasing sea level on surface elevation gains and contributing processes (accretion on the surface, subsidence and root growth) in mangrove forests. We found that soil surface elevation increased with mean sea level (which varied over 250 mm during the study) and with turbidity at sites where fine sediment in the water column is abundant. In contrast, where sediments were sandy, rates of surface elevation gain were high, but not significantly related to variation in turbidity, and were likely to be influenced by other factors that deliver sand to the mangrove forest. Root growth was not linked to soil surface elevation gains, although it was associated with reduced shallow subsidence, and therefore may contribute to the capacity of mangroves to keep pace with sea level rise. Our results indicate both surface (sedimentation) and subsurface (root growth) processes can influence mangrove capacity to keep pace with sea level rise within the same geographic location, and that current models of tidal marsh responses to sea level rise capture the major feature of the response of mangroves where fine, but not coarse, sediments are abundant.

  11. Factors controlling spatial variability of DOC concentrations in soil solution at European level

    Science.gov (United States)

    Camino Serrano, Marta; Janssens, Ivan; Luyssaert, Sebastiaan; Gielen, Bert; Guenet, Bertrand; De Vos, Bruno; Ciais, Philippe

    2013-04-01

    The lateral transport of dissolved organic carbon (DOC) is an important and not well-understood process linking terrestrial and aquatic ecosystems. Up to day very few Earth System Models (ESMs) represent explicitly this process despite its crucial role in the global carbon cycle. However, to be able to integrate DOC leaching in ESMs, more accurate information is needed in order to better understand and predict DOC dynamics. DOC concentrations mainly vary by geographical location, soil and vegetation types, topography, season and climate. Within this framework, a database was designed to compile data on DOC in soil solution at different depths in different ecosystems around the world, with special focus on European sites. The database contains information on 349 sites, with 304 being forest, gathered from published literature and datasets accessible on the internet. A substantial dataset was provided by International Co-operative Programme on Assessment and Monitoring of Air Pollution Effects on Forests (ICP Forests). The database also includes other meta-data related to the sites, such as land cover, soil properties, climate, annual water balance and other soil solution parameters. The analysis of the database has been focused on: 1) the study of the environmental and physical factors that are acting as drivers of DOC concentrations changes in soil solution across sites at European level , and 2) the DOC distribution through the soil profile and how this varies with different vegetation types and soil properties. The preliminary results show that variables related to biological processes (Dry weight of the organic layer, for example) are the most important in explaining the spatial distribution of the DOC concentration in soil solution at the European scale. However, the interactions between variables are complex and we will need further analysis in order to draw more robust conclusions. With regards to the vertical profile of DOC, we found that there is a

  12. Controls on lava lake level at Halema`uma`u Crater, Kilauea Volcano

    Science.gov (United States)

    Patrick, M. R.; Orr, T. R.

    2013-12-01

    Lava level is a fundamental measure of lava lake activity, but very little continuous long-term data exist worldwide to explore this aspect of lava lake behavior. The ongoing summit eruption at Kilauea Volcano began in 2008 and is characterized by an active lava lake within the eruptive vent. Lava level has been measured nearly continuously at Kilauea for several years using a combination of webcam images, laser rangefinder, and terrestrial LIDAR. Fluctuations in lava level have been a common aspect of the eruption and occur over several timescales. At the shortest timescale, the lava lake level can change over seconds to hours owing to two observed shallow gas-related processes. First, gas pistoning is common and is driven by episodic gas accumulation and release from the surface of the lava lake, causing the lava level to rise and fall by up to 20 m. Second, rockfalls into the lake trigger abrupt gas release, and lava level may drop as much as 10 m as a result. Over days, cyclic changes in lava level closely track cycles of deflation-inflation (DI) deformation events at the summit, leading to level changes up to 50 m. Rift zone intrusions have caused large (up to 140 m) drops in lava level over several days. On the timescale of weeks to months, the lava level follows the long-term inflation and deflation of the summit region, resulting in level changes up to 140 m. The remarkable correlation between lava level and deflation-inflation cycles, as well as the long-term deformation of the summit region, indicates that the lava lake acts as a reliable 'piezometer' (a measure of liquid pressure in the magma plumbing system); therefore, assessments of summit pressurization (and rift zone eruption potential) can now be carried out with the naked eye. The summit lava lake level is closely mirrored by the lava level within Pu`u `O`o crater, the vent area for the 30-year-long eruption on Kilauea's east rift zone, which is 20 km downrift of the summit. The coupling of these

  13. Associations between Self-Control, Practice, and Skill Level in Sport Expertise Development

    Science.gov (United States)

    Tedesqui, Rafael A. B.; Young, Bradley W.

    2017-01-01

    Purpose: The purpose of this study was to test the association between self-control (SC) variables and (a) sport-specific practice amounts, (b) engagement in various practice contexts, (c) threats to commitment to one's sport, and (d) skill development using the Brief Self-Control Scale (BSCS) in a diverse sport sample. Method: Two hundred…

  14. An Analysis of University Students' Levels of Self-Control According to Their Ego States

    Science.gov (United States)

    Kaygusuz, Canani; Ozpolat, Ahmet Ragip

    2016-01-01

    Problem Statement: Although it is well known that parents' methods of raising their children significantly affect their children's personalities and how they face life, this study has been designed because there is a lack of specific research on which ego states of adults are associated with self-control. In the present study, self-control and ego…

  15. Current levels of suppression of waterhyacinth in Florida by classical biological control agents

    Science.gov (United States)

    Waterhyacinth, Eichhornia crassipes, has been a global target for classical biological control efforts for decades. In Florida, herbicides are the primary tactic employed, usually without regard for the activities of the three biological control agents introduced intentionally during the 1970's, na...

  16. The harm principle as a mid-level principle?: three problems from the context of infectious disease control.

    Science.gov (United States)

    Krom, André

    2011-10-01

    Effective infectious disease control may require states to restrict the liberty of individuals. Since preventing harm to others is almost universally accepted as a legitimate (prima facie) reason for restricting the liberty of individuals, it seems plausible to employ a mid-level harm principle in infectious disease control. Moral practices like infectious disease control support - or even require - a certain level of theory-modesty. However, employing a mid-level harm principle in infectious disease control faces at least three problems. First, it is unclear what we gain by attaining convergence on a specific formulation of the harm principle. Likely candidates for convergence, a harm principle aimed at preventing harmful conduct, supplemented by considerations of effectiveness and always choosing the least intrusive means still leave ample room for normative disagreement. Second, while mid-level principles are sometimes put forward in response to the problem of normative theories attaching different weight to moral principles, employing a mid-level harm principle completely leaves open how to determine what weight to attach to it in application. Third, there appears to be a trade-off between attaining convergence and finding a formulation of the harm principle that can justify liberty-restrictions in all situations of contagion, including interventions that are commonly allowed. These are not reasons to abandon mid-level theorizing altogether. But there is no reason to be too theory-modest in applied ethics. Morally justifying e.g. if a liberty-restriction in infectious disease control is proportional to the aim of harm-prevention, promptly requires moving beyond the mid-level harm principle. © 2011 Blackwell Publishing Ltd.

  17. Design of the control law of the steam drum boiler level taking into consideration energy economy

    Directory of Open Access Journals (Sweden)

    Juravliov A.A.

    2005-12-01

    Full Text Available The cascade system for maintaining the level in the steam boiler drum was investigated. Main features of the system are it’s variable structure which changes depending on the load variation relative to its previous value, and the use of the model of the drum level in dependence of the feedwater flow rate.

  18. Electrochemical Control of Single-Molecule Conductance by Fermi- Level Tuning and Conjugation Switching

    DEFF Research Database (Denmark)

    Baghernejad, Masoud; Zhao, Xiaotao; Ørnsø, Kristian Baruël

    2014-01-01

    ) centers, over >1 order of magnitude. For electrode potentials outside the redox-active region, the effect of the gate is simply to shift the molecular energy levels relative to the metal Fermi level. At the redox potential, the conductance changes abruptly as the AQ unit is oxidized...

  19. Control and Modeling of Push-Pull Forward Three-Level Converter for Microgrid

    DEFF Research Database (Denmark)

    Yao, Zhilei; Xu, Jing; Guerrero, Josep M.

    2015-01-01

    Renewable energy sources are widely used in microgrid. Output voltage of them is often low and varies widely. Because diodes in three-level legs in traditional three-level (TL) converter are substituted by MOSFETs, the push-pull forward (PPF) TL converter is very suitable for wide and low...

  20. Doping Level of Boron-Doped Diamond Electrodes Controls the Grafting Density of Functional Groups for DNA Assays.

    Science.gov (United States)

    Švorc, Ĺubomír; Jambrec, Daliborka; Vojs, Marian; Barwe, Stefan; Clausmeyer, Jan; Michniak, Pavol; Marton, Marián; Schuhmann, Wolfgang

    2015-09-02

    The impact of different doping levels of boron-doped diamond on the surface functionalization was investigated by means of electrochemical reduction of aryldiazonium salts. The grafting efficiency of 4-nitrophenyl groups increased with the boron levels (B/C ratio from 0 to 20,000 ppm). Controlled grafting of nitrophenyldiazonium was used to adjust the amount of immobilized single-stranded DNA strands at the surface and further on the hybridization yield in dependence on the boron doping level. The grafted nitro functions were electrochemically reduced to the amine moieties. Subsequent functionalization with a succinic acid introduced carboxyl groups for subsequent binding of an amino-terminated DNA probe. DNA hybridization significantly depends on the probe density which is in turn dependent on the boron doping level. The proposed approach opens new insights for the design and control of doped diamond surface functionalization for the construction of DNA hybridization assays.

  1. Electrically controlled crossing of energy levels in quantum dots in two-dimensional topological insulators

    Energy Technology Data Exchange (ETDEWEB)

    Sukhanov, Aleksei A.

    2017-05-15

    We study the energy spectra of bound states in quantum dots (QDs) formed by an electrostatic potential in two-dimensional topological insulator (TI) and their transformation with changes in QD depth and radius. It is found that, unlike a trivial insulator, the energy difference between the levels of the ground state and first excited state can decrease with decreasing the radius and increasing the depth of the QD so that these levels intersect under some critical condition. The crossing of the levels results in unusual features of optical properties caused by intraceneter electron transitions. In particular, it leads to significant changes of light absorption due to electron transitions between such levels and to the transient electroluminescence induced by electrical tuning of QD and TI parameters. In the case of magnetic TIs, the polarization direction of the absorbed or emitted circularly polarized light is changed due to the level crossing.

  2. An Artificial Neural Network Compensated Output Feedback Power-Level Control for Modular High Temperature Gas-Cooled Reactors

    Directory of Open Access Journals (Sweden)

    Zhe Dong

    2014-02-01

    Full Text Available Small modular reactors (SMRs could be beneficial in providing electricity power safely and also be viable for applications such as seawater desalination and heat production. Due to its inherent safety features, the modular high temperature gas-cooled reactor (MHTGR has been seen as one of the best candidates for building SMR-based nuclear power plants. Since the MHTGR dynamics display high nonlinearity and parameter uncertainty, it is necessary to develop a nonlinear adaptive power-level control law which is not only beneficial to the safe, stable, efficient and autonomous operation of the MHTGR, but also easy to implement practically. In this paper, based on the concept of shifted-ectropy and the physically-based control design approach, it is proved theoretically that the simple proportional-differential (PD output-feedback power-level control can provide asymptotic closed-loop stability. Then, based on the strong approximation capability of the multi-layer perceptron (MLP artificial neural network (ANN, a compensator is established to suppress the negative influence caused by system parameter uncertainty. It is also proved that the MLP-compensated PD power-level control law constituted by an experientially-tuned PD regulator and this MLP-based compensator can guarantee bounded closed-loop stability. Numerical simulation results not only verify the theoretical results, but also illustrate the high performance of this MLP-compensated PD power-level controller in suppressing the oscillation of process variables caused by system parameter uncertainty.

  3. PLANT - An experimental task for the study of human problem solving in process control. [Production Levels and Network Troubleshooting

    Science.gov (United States)

    Morris, N. M.; Rouse, W. B.; Fath, J. L.

    1985-01-01

    An experimental tool for the investigation of human problem-solving behavior is introduced. Production Levels and Network Troubleshooting (PLANT) is a computer-based process-control task which may be used to provide opportunities for subjects to control a dynamic system and diagnose, repair, and compensate for system failures. The task is described in detail, and experiments which have been conducted using PLANT are briefly discussed.

  4. Inflammatory markers in meconium induced lung injury in neonates and effect of steroids on their levels: A randomized controlled trial

    OpenAIRE

    Tripathi S; Saili A; Dutta R

    2007-01-01

    Purpose: To determine the levels of TNFα and IL-1β in tracheal aspirates of neonates with meconium aspiration syndrome (MAS) and to ascertain whether the use of steroids by systemic or nebulized routes suppresses the levels of these inflammatory markers. Methods: This was a double blind, randomized, controlled, prospective, interventional study done over one year period in the neonatal unit of the Lady Hardinge Medical College. Fifty-one babies of MAS which were randomly distr...

  5. Accreditation proposal for control systems in electrical engineering for 6th level in European Qualification Framework (EQF)

    DEFF Research Database (Denmark)

    Tsirigotis, Georgios; Friesel, Anna

    2013-01-01

    The progress of science and technology emphasizes the connection between different domains and disciplines. The technology development and changing demands of the labour market require upgrading and renewing of learning outcomes in higher education, especially in engineering fields. The Life Long...... the necessary learning outcomes in the subject of Control Systems in engineering at Bachelor level (6th level of European Qualification Framework (EQF) and propose a process to test the qualifications. © 2013 IEEE....

  6. GUI Of Control System On The Level Of Oil Tank By Two Pumps Using V. Basic

    Directory of Open Access Journals (Sweden)

    Qusay Jalil

    2015-08-01

    Full Text Available Abstract Science is developing applications in all fields medical industrial agricultural military .... etc. private computer applications and at the moment has become easier development tasks through a computer which controls the systems through the so-called graphical user interface GUI where it is through the graphical interface to control the whole system in terms of operating appeared maintenance and other this is not only but rather can handle the graphical interface by any person who is not a specialist in the field of control of any It simplifies dealing with the system by the designer person.This paper represents a simplification of the work of control is full of a large volume of fuel tank system as in factories through the two pumps and valves discharge consists of control system of two parts 1- Software 2- Hardware for Soft is the part of the compiler is responsible for receiving data processed and giving orders to the hardware for the purpose of implementation.This is done simulations of the system through the graphical user interface GUI designed under the working environment V.BASIC by a specialist engineer to be controlled by someone less experienced in the field of control

  7. A Lyapunov Stability Theory-Based Control Strategy for Three-Level Shunt Active Power Filter

    Directory of Open Access Journals (Sweden)

    Yijia Cao

    2017-01-01

    Full Text Available The three-phase three-wire neutral-point-clamped shunt active power filter (NPC-SAPF, which most adopts classical closed-loop feedback control methods such as proportional-integral (PI, proportional-resonant (PR and repetitive control, can only output 1st–25th harmonic currents with 10–20 kHz switching frequency. The reason for this is that the controller design must make a compromise between system stability and harmonic current compensation ability under the condition of less than 20 kHz switching frequency. To broaden the bandwidth of the compensation current, a Lyapunov stability theory-based control strategy is presented in this paper for NPC-SAPF. The proposed control law is obtained by constructing the switching function on the basis of the mathematical model and the Lyapunov candidate function, which can avoid introducing closed-loop feedback control and keep the system globally asymptotically stable. By means of the proposed method, the NPC-SAPF has compensation ability for the 1st–50th harmonic currents, the total harmonic distortion (THD and each harmonic content of grid currents satisfy the requirements of IEEE Standard 519-2014. In order to verify the superiority of the proposed control strategy, stability conditions of the proposed strategy and the representative PR controllers are compared. The simulation results in MATLAB/Simulink (MathWorks, Natick, MA, USA and the experimental results obtained on a 6.6 kVA NPC-SAPF laboratory prototype validate the proposed control strategy.

  8. The Effects of P, I and D Parameters in Automatic Liquid Level Control Using UniTrain Module

    Directory of Open Access Journals (Sweden)

    Alfatirta Mufti

    2013-04-01

    Full Text Available The research discusses some experiments to control the level of liquid inside a tank by using PID controllers which can be divided into four categories. The experiments describe the effect of P, I, and D element. It also discusses the best possible controller, which is a PI controller, for the liquid level tank system. The liquid level controlling is done by adjusting the voltage pump which will further regulate the flow rate of the fluid entering the inlet valve. The liquid that flows through the outlet valve is considered as the disturbance variable to the system. The liquid tank sensor needs to be calibrated prior to the experiments. Calibration can be done manually by using a digital multimeter or by using the computer sofware that is connected directly to the plant system. Set point and PID parameters are determined by the UniTrain and the computer interface. In these experiments, PI controller has the best result with a medium proportional gain (KP = 5 and a small integral gain (TN = 0.2.

  9. Problem of two-level hierarchical minimax program control the final state of regional social and economic system with incomplete information

    Science.gov (United States)

    Shorikov, A. F.

    2016-12-01

    In this article we consider a discrete-time dynamical system consisting of a set a controllable objects (region and forming it municipalities). The dynamics each of these is described by the corresponding linear or nonlinear discrete-time recurrent vector relations and its control system consist from two levels: basic level (control level I) that is dominating level and auxiliary level (control level II) that is subordinate level. Both levels have different criterions of functioning and united by information and control connections which defined in advance. In this article we study the problem of optimization of guaranteed result for program control by the final state of regional social and economic system in the presence of risks vectors. For this problem we propose a mathematical model in the form of two-level hierarchical minimax program control problem of the final states of this system with incomplete information and the general scheme for its solving.

  10. H∞ Control of Supply Chain Based on Switched Model of Stock Level

    Directory of Open Access Journals (Sweden)

    Junzhi Luo

    2014-01-01

    Full Text Available This paper is concerned with the problem of H∞ control for a class of discrete supply chain systems. A new method based on network control technique is presented to address this issue. Supply chain systems are modeled as networked systems with stochastic time delay. Sufficient conditions for H∞ controller design are given in terms of a set of linear matrix inequalities, based on which the mean-square asymptotic stability as well as H∞ performance is satisfied for such systems. Simulation results are provided to demonstrate the effectiveness of the proposed method.

  11. Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels

    DEFF Research Database (Denmark)

    Gopal, Sandeep; Søgaard, Pernille; Multhaupt, Hinke A B;

    2015-01-01

    show that syndecans regulate transient receptor potential canonical (TRPCs) channels to control cytosolic calcium equilibria and consequent cell behavior. In fibroblasts, ligand interactions with heparan sulfate of syndecan-4 recruit cytoplasmic protein kinase C to target serine714 of TRPC7...... with subsequent control of the cytoskeleton and the myofibroblast phenotype. In epidermal keratinocytes a syndecan-TRPC4 complex controls adhesion, adherens junction composition, and early differentiation in vivo and in vitro. In Caenorhabditis elegans, the TRPC orthologues TRP-1 and -2 genetically complement...

  12. Cell-level battery charge/discharge protection system. [electronic control techniques

    Science.gov (United States)

    Donovan, R. L.; Imamura, M. S.

    1977-01-01

    The paper describes three design approaches to individual cell monitoring and control for sealed secondary battery cells. One technique involves a modular strap-on single cell protector which contains all the electronics required for monitoring cell voltage, responding to external commands, and forming a bypass circuit for the cell. A second technique, the multiplexed cell protector, uses common circuitry to monitor and control each cell in a battery pack. The third technique, the computerized cell protector, by replacing the hard-wired logic of the multiplexed cell protector with a microprocessor, achieves greatest control flexibility and inherent computational capability with a minimum parts count implementation.

  13. Distributed control and monitoring of high-level trigger processes on the LHCb online farm

    CERN Document Server

    Vannerem, P; Jost, B; Neufeld, N

    2003-01-01

    The on-line data taking of the LHCb experiment at the future LHC collider will be controlled by a fully integrated and distributed Experiment Control System (ECS). The ECS will supervise both the detector operation (DCS) and the trigger and data acquisition (DAQ) activities of the experiment. These tasks require a large distributed information management system. The aim of this paper is to show how the control and monitoring of software processes such as trigger algorithms are integrated in the ECS of LHCb.

  14. Effect of exercise on postmenopausal sex hormone levels and role of body fat: a randomized controlled trial.

    Science.gov (United States)

    Monninkhof, Evelyn M; Velthuis, Miranda J; Peeters, Petra H M; Twisk, Jos W R; Schuit, Albertine J

    2009-09-20

    To examine the effects of a 1-year exercise intervention on sex hormone levels in postmenopausal women and whether any effects are mediated by changes in body fat composition. We randomly assigned 189 sedentary postmenopausal women (age 50 to 69 years, body mass index of 22 to 40 kg/m(2)) to an exercise intervention (n = 96) or a control group (n = 93). The intervention combined aerobic and strength training and comprised supervised group sessions and home-based exercises (a total of 2.5 h/wk). Between-group differences in sex hormone levels (at baseline and 4 and 12 months) were examined with generalized estimating equations. In total, 183 women (97%) completed the study. Overall, the exercise intervention did not result in favorable effects on sex hormone levels. Among women who lost more than 2% body fat, declines in all estrogens were not significantly different between exercisers and controls. Androgen levels decreased significantly in the exercise group who lost body fat compared with their peers in the control group. Furthermore, this study confirmed that fat loss was significantly associated with declines in postmenopausal estrogen levels. Although not significant, a similar trend was observed for the androgens. This study confirms that fat loss is associated with changes in postmenopausal sex hormone levels and suggests that exercise may be effective in inducing favorable changes in these hormones.

  15. Determination of 3,5,6-trichloro-2-pyridinol levels in the urine of termite control workers using chlorpyrifos.

    Directory of Open Access Journals (Sweden)

    Jitsunari,Fumihiko

    1989-10-01

    Full Text Available Chlorpyrifos, an organophosphorus insecticide, has been used to control termites since regulatory measures against the use of chlordanes were taken in September, 1986. We developed an improved gas chromatographic (GC method for the assay of 3,5,6-trichloro-2-pyridinol (TCP in the urine to use in the biological monitoring of exposure to chlorpyrifos. Urinary TCP was separated and determined accurately (C.V., 4% with high sensitivity (detection limit, 10 ng/ml and recovery (recovery greater than 90% using a wide bore capillary column (WBC column. The accuracy and precision of the present GC method are satisfactory. The time course of urinary excretion of TCP was followed in workers. The urinary TCP level was low in the off-season and high in the busy season. Variation in the urinary TCP level corresponded to the termite control season and the length of the working period. The urinary TCP level showed a change reciprocal to the variations in the plasma cholinesterase activity. From these results, it is surmised that the urinary TCP level represents the extent of exposure to chlorpyrifos. The decrease in the level of cholinesterase activity is suggested to be due to exposure to chlorpyrifos. Determination of the urinary TCP level by GC using a WBC column is useful in the biological monitoring of chlorpyrifos in termite control workers and potentially has practical application to health care.

  16. Changes in Circulating Levels and Ratios of Angiopoietins during Pregnancy, but not during the Menstrual Cycle and Controlled Ovarian Stimulation

    Science.gov (United States)

    Hurliman, Amanda K.; Speroff, Leon; Stouffer, Richard L.; Patton, Phillip E.; Lee, Annette; Molskness, Theodore A.

    2009-01-01

    OBJECTIVE This study was designed to determine if angiopoietin (ANGPT)-1 and -2 are detectable in the circulation of nonhuman primates and women, and if these levels fluctuate in association with ovarian activity. DESIGN Prospective SETTING National Primate Research Center, medical center and infertility clinic. PATIENTS Adult, female rhesus monkeys; 15 women donating oocytes for infertility treatment. INTERVENTIONS Controlled ovarian stimulation with gonadotropins, removal of the corpus luteum and ovaries, oocyte retrieval and embryo transfer. MAIN OUTCOME MEASURE Circulating levels of ANGPT-1 and ANGPT-2. RESULTS Serum ANGPT-1 and ANGPT-2 levels were detectable and invariant in maintaining an ANGPT1:2 ratio >1 in: (a) macaques over the course of the natural menstrual cycle, during a controlled ovulation protocol and following removal of the corpus luteum or ovaries, and (b) women undergoing controlled ovarian simulation (COS). In contrast, the ANGPT1:2 ratio was markedly decreased (≪1) at mid-to-late gestation in macaques, and in the follicular fluid of women undergoing COS, due to increased levels of ANGPT-2. CONCLUSIONS The ovary and its dominant structures are not major contributors to circulating levels of ANGPT-1 or ANGPT-2. The physiologic importance of the rising levels of ANGPT-2 after the luteal-placental shift in pregnancy is unknown. PMID:19476937

  17. Luminosity control and beam orbit stability with beta star leveling at LHC and HL-LHC

    CERN Document Server

    Gorzawski, Arkadiusz Andrzej; Wenninger, Jorg

    This thesis describes the wide subject of the luminosity leveling and its requirements for the LHC and the HL-LHC. We discuss the advantages and disadvantages of different leveling methods focusing the thesis on the beta star leveling technique. We review the beams offset build--up due to the environmental (i.e. natural ground motion) and mechanical (i.e. moving quadrupole) sources. We quantify the instrumentation requirements for the reliable and reproducible operation with small offsets at the interaction points. Last but not least, we propose a novel method for the beam offset stabilization at the collision point based on the feedback from the luminosity.

  18. Bacteria-foraging based-control of high-performance railway level-crossing safety drives fed from photovoltaic array

    Directory of Open Access Journals (Sweden)

    Essamudin A. Ebrahim

    2016-12-01

    Full Text Available In the past ten years, railway level-crossing accidents have noticeably escalated in an indisputably preposterous manner, this devastating snag opened the floodgates for the frustrating death of a numerous number of the third world’s citizens, especially in Egypt. To tackle with this problem, a fully intelligent control system is required, which must be automated without human intervention. So, in this research, a new proposed level-crossing tracking system is designed and introduced. The system comprises a high-performance induction motor (IM fed from photovoltaic (PV array, the boom barrier (gate with its mechanism – as a load – buck–boost converter, inverter, and two smart PI-controllers. The first one is designed to regulate the duty cycle of the converter to its optimum value required to balance between maximum power point tracking (MPPT and keeping dc-link voltage of the inverter at a minimum level needed to maintain the motor internal torque at rated value. The second PI-controller is designed for speed control of indirect field-oriented vector-control (IFO-VC IM. The proposed design problems of MPPT, dc-link voltage and speed controllers are solved as optimization problems by bacteria-foraging optimization (BFO algorithm to search for the optimal PI-parameters. The simulation test results are acquired when using the battery-less PV-array with and without the proposed controllers. Also, results are obtained when applying several prescribed speed trajectories to test the robustness against PV-irradiance fluctuations and motor-dynamic disturbances. From these results, the proposed intelligent controllers are robust compared to classical Ziegler–Nichols (ZN PI-controllers and also when the motor is directly fed from PV generator without converter.

  19. Effects of supervised structured aerobic exercise training program on fasting blood glucose level, plasma insulin level, glycemic control, and insulin resistance in type 2 diabetes mellitus.

    Science.gov (United States)

    Shakil-Ur-Rehman, Syed; Karimi, Hossein; Gillani, Syed Amir

    2017-01-01

    To determine the effects of supervised structured aerobic exercise training (SSAET) program on fasting blood glucose level (FBGL), plasma insulin level (PIL), glycemic control (GC), and insulin resistance (IR) in type 2 diabetes mellitus (T2DM). Riphah Rehabilitation and Research Centre (RRRC) was the clinical setting for this randomized controlled trial, located at Pakistan Railways General Hospital (PRGH), Rawalpindi, Pakistan. Study duration was 18 months from January 1, 2015 to June 30, 2016. Patients of both genders ranging 40-70 years of age with at least one year of history of T2DM were considered eligible according to WHO criteria, while patients with other chronic diseases, history of smoking, regular exercise and diet plan were excluded. Cohorts of 195 patients were screened out of whom 120 fulfilled the inclusion criteria. Amongst them 102 agreed to participate and were assigned to experimental (n=51) and control (n=51) groups. Experimental group underwent SSAET program, routine medication and dietary plan, whereas the control group received routine medication and dietary plan, while both group received treatment for 25 weeks. The blood samples were taken at baseline and on the completion of 25 weeks. The investigation of fasting blood glucose level, plasma insulin level, and glycemic control was conducted to calculate IR. Patients with T2DM in experimental group (n=51) treated with SSAET program, routine medication and dietary plan significantly improved FBGL (pre-mean= 276.41±25.31, post-mean=250.07±28.23), PIL (pre-mean=13.66±5.31, post-mean=8.91±3.83), GC (pre-mean=8.31±1.79, post-mean 7.28±1.43), and IR (pre-mean=64.95±27.26, post-mean 37.97±15.58), as compared with patients in control group treated with routine medication and dietary plan in whom deteriorations were noted in FBGL (pre-mean=268.19±22.48, post-mean=281.41±31.30), PIL(pre-mean=14.14±5.48, post-mean=14.85±5.27) GC (pre-mean=8.15±1.74, post-mean=8.20±1.44, and IR (pre

  20. System-Level Development of Fault-Tolerant Distributed Aero-Engine Control Architecture Project

    Data.gov (United States)

    National Aeronautics and Space Administration — NASA's vision for an "intelligent engine" will be realized with the development of a truly distributed control system and reliable smart transducer node components;...

  1. Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.

    Science.gov (United States)

    Xiang, Hui; Hu, Bo; Li, Zhifeng; Li, Jianguo

    2014-10-01

    Previous studies have shown that dexmedetomidine exerted anti-inflammatory effect on several animal models with inflammation, but the mechanism is not clear. This study intends to elucidate the anti-inflammatory mechanism of dexmedetomidine through the cholinergic anti-inflammatory pathway. To investigate this therapeutic potential of dexmedetomidine, a murine model of endotoxemia was established induced by lipopolysaccharide (LPS). Animals were assigned to one of four protocols. Protocol one: animals were randomly assigned to control group, dexmedetomidine group, and sterile saline group (n=20 each), and these animals were used for survival analysis. The survival rate was assessed up to 120 h after endotoxin injection. Protocol two: animals were randomly assigned to one of four groups (n=16 each): group 1 (group Saline), treated with sterile saline 15 min prior to endotoxin treatment (10 mg kg(-1) over 2 min); group 2 (group Dex), treated with dexmedetomidine 15 min prior to endotoxin treatment; group 3 (group αBGT+Dex), treated with alpha-7 nicotinic acetylcholine receptors (α7nAChR) antagonist alpha-bungarotoxin (αBGT, 1 μg/kg) 15 min prior to dexmedetomidine treatment; group 4 (group saline+Dex), treated with equivalent sterile saline 15 min prior to dexmedetomidine treatment. Protocol three: animals were randomly assigned to one of two groups (n=16 each): vagotomy group (group VNX+Dex), right cervical vagus nerve was exposed and transected; sham-operated group (group SHAM+Dex), the cervical vagus nerve was visualized, but was neither isolated from the surrounding tissues nor transected. Protocol four: animals were treated with dexmedetomidine (40 μg/kg) and sterile saline to observe the discharge activity of cervical vagus nerves by using BL-420F data acquisition and analysis system (n=16 each). In the survival analysis groups, the survival rate of dexmedetomidine group was significantly higher than that of the endotoxemia group (65 versus 25

  2. Control Method of Three-level Neutral-point-clamped Inverter Based on Voltage Vector Diagram Partition

    Institute of Scientific and Technical Information of China (English)

    SONG Wen-xiang; YAO Gang; CHEN Chen; CHEN Guo-cheng

    2008-01-01

    A new modulation approach was presented for the control of neutral-point (NP) voltage variation in the three-level NP-clamped voltage source inverter, and the average NP current model was established based on vector diagram partition. Thus, theory base was built for balancing control of NP potential. Theoretical analysis and experimental results indicate that the proposed method for NP balancing control vector synthesizing concept based can make the average NP current zero, and do not influence NP potential within every sample period. The effectiveness of proposed research approach was verified by simulative and experimental results.

  3. High performance control strategy for single-phase three-level neutral-point-clamped traction four-quadrant converters

    DEFF Research Database (Denmark)

    Kejian, Song; Konstantinou, Georgios; Jing, Li

    2017-01-01

    Operational data from Chinese railways indicate a number of challenges for traction four-quadrant converter (4QC) control including low-order voltage and current harmonics and reference tracking. A control strategy for a single-phase three-level neutral-point-clamped 4QC employed in the electric...... multiple unit traction system is proposed in this study. The strategy is based on a multiple frequency tuned quasi-proportional resonant controller in the ac-side current loop and a multiple frequency tuned notch filter in the dc-link voltage loop. Under the typical supply voltage distortion present...

  4. Report: EPA Needs to Strengthen Internal Controls for Determining Workforce Levels

    Science.gov (United States)

    Report #11-P-0031, December 20, 2010. EPA’s policies and procedures do not include a process for determining employment levels based on workload as prescribed by the Office of Management and Budget.

  5. Contextual control of audiovisual integration in low-level sensory cortices

    NARCIS (Netherlands)

    Van Atteveldt, N.; Peterson, Bradley S; Schroeder, Charles E

    2014-01-01

    Potential sources of multisensory influences on low-level sensory cortices include direct projections from sensory cortices of different modalities, as well as more indirect feedback inputs from higher order multisensory cortical regions. These multiple architectures may be functionally complementar

  6. Synthesis and Control of Flexible Systems with Component-Level Uncertainties

    Science.gov (United States)

    Maghami, Peiman G.; Lim, Kyong B.

    2009-01-01

    An efficient and computationally robust method for synthesis of component dynamics is developed. The method defines the interface forces/moments as feasible vectors in transformed coordinates to ensure that connectivity requirements of the combined structure are met. The synthesized system is then defined in a transformed set of feasible coordinates. The simplicity of form is exploited to effectively deal with modeling parametric and non-parametric uncertainties at the substructure level. Uncertainty models of reasonable size and complexity are synthesized for the combined structure from those in the substructure models. In particular, we address frequency and damping uncertainties at the component level. The approach first considers the robustness of synthesized flexible systems. It is then extended to deal with non-synthesized dynamic models with component-level uncertainties by projecting uncertainties to the system level. A numerical example is given to demonstrate the feasibility of the proposed approach.

  7. Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (S) levels in medicated patients with major depressive disorder compared with controls.

    Science.gov (United States)

    Kurita, Hirofumi; Maeshima, Hitoshi; Kida, Sayaka; Matsuzaka, Hisashi; Shimano, Takahisa; Nakano, Yoshiyuki; Baba, Hajime; Suzuki, Toshihito; Arai, Heii

    2013-04-05

    There is accumulating evidence regarding gender differences in clinical symptoms or response to antidepressants in patients with depression. However, less attention has been given to sex differences in the underlying biological mechanisms of depression. The adrenal androgens, dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEA-S), play a critical role in controlling affect, mood, and anxiety. Changes in serum adrenal androgen levels have been reported in conditions pertaining to stress as well as in psychiatric disorders. The objective of the present study was to investigate differences in serum levels of adrenal androgens in male and female patients with major depressive disorder (MDD). Participants included 90 inpatients with MDD at the psychiatric ward of Juntendo University Koshigaya Hospital who were receiving antidepressants. Serum levels of DHEA and DHEA-S were assessed at the time of admission. Matched controls (based on sex and age) included 128 healthy individuals. First, data from male and female MDD patients and controls were compared. Second, correlations between serum hormone levels and scores on the Hamilton Rating Scale for Depression (HAM-D) of patients with MDD were assessed by gender. In addition, effects of various factors on adrenal androgens were analyzed using multiple regression analysis. Serum DHEA levels were significantly increased in both male and female MDD patients compared with controls. Serum levels of DHEA-S in male patients were significantly decreased compared with male controls, whereas no significant differences were seen in female patients and controls. No significant correlations among adrenal androgens were observed in male patients with MDD, whereas significant positive correlations were found in both male and female controls. No significant correlations were seen between adrenal androgens and HAM-D scores in male or female patients. Multiple regression analysis showed that both hormones were affected by the age

  8. Unifying the Access Control Mechanism for the Enterprises Using XACML Policy Levels

    Directory of Open Access Journals (Sweden)

    N. Senthil Kumar

    2015-11-01

    Full Text Available —Many enterprises have intended to promote their applications with stern access control mechanism and yield the stringent authorization deployment in their individual proprietary manner. The development of this build up will result in tight coupling of authorization mechanisms within the enterprise applications. In many enterprises setup, the implicit authorization processes are embedded within the application and promote error prone accessing of requested policies. This sort of embedded authorization will let the users to carry out the specific actions without knowing the access control policy as well as its embedded setup with the help of third party involvement. But this approach has some serious effects in controlling the issues such as skipping the trust based applications, violates the policy setups and pave the way to exploit the authorized data to the end users. Many enterprises had faced serious problem in controlling its sensitive data from this implicit authorization decisions and hence decided to develop a security mechanism which can be totally controlled by centralized way of access policy. Therefore, the eXtensible Access Control Markup Language (XACML provides a very simple and powerful remedy for authorization mechanism and for the access policy set ups.

  9. Design of water level control system based on ARM%基于ARM的水位控制系统

    Institute of Scientific and Technical Information of China (English)

    党长青; 陈湘萍

    2014-01-01

    随着现代社会生产的发展和技术进步,微电子技术的飞速发展,水位控制的应用也越来越广泛。本文介绍了水位检测电路并进而控制水位高度的电路原理和电路的实际设计,系统以STM32微控制器作为系统的控制核心,以超声波电路作为检测传感电路,实现对水位的控制。该电路具有精度高,易于控制的特点。本文详细论述了按该原理进行水位控制的电路设计方案。%With the development of modern social production and technological,the increasingly rapid development of microeletronics technology,the application of water level control is becoming more and more widely.This paper introduces the circuit principle and the design of the circuit of the water level detection circuit which controls the height of the water level.The system uses STM32 microcontrol er as the control core of the system,and the ultrasonic circuit as the detecting sensor circuit,to control the system for the water level.The circuit has a high precision and is easy to control.This paper discusses the circuit design which controls the water level on the basis of above principle.

  10. Circulating irisin levels are not affected by coffee intake: a randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Patricia R Peter

    Full Text Available Irisin, secreted by skeletal muscle and possibly fat, is hypothesized to play an important role in modulating energy expenditure, obesity and metabolism. Coffee consumption also increases energy expenditure and leads to positive metabolic effects, but whether these effects are mediated by irisin remains unknown. The objective of this study was to determine the association between baseline irisin levels and the metabolic profile in humans and to investigate whether consumption of caffeinated coffee alters irisin levels. To this end, a secondary analysis was performed investigating irisin levels at baseline and after eight weeks in 32 healthy, overweight coffee drinkers who were randomized to consumption of 5 cups per day of instant caffeinated coffee, decaffeinated coffee, or water. Spearman correlation and analysis of covariance analyses were performed to identify possible associations. Irisin levels were positively correlated with waist circumference (r = 0.41, p = 0.02, fat mass (r = 0.44, p = 0.01 and CRP (r = 0.47, p = 0.007. Though there was a trend towards increased levels of irisin over time in the caffeinated coffee group (+1.8% when compared to the placebo group (24% this did not reach statistical significance (p = 0.75 for the trend. This first randomized trial failed to reveal any effects of coffee consumption on irisin levels, but a larger trial, appropriately sized on the basis of data provided by this study, is needed to conclusively investigate such a relationship.Clinicaltrials.gov NCT00305097.

  11. Impact of the Bienestar school-based diabetes mellitus prevention program on fasting capillary glucose levels: a randomized controlled trial.

    Science.gov (United States)

    Treviño, Roberto P; Yin, Zenong; Hernandez, Arthur; Hale, Daniel E; Garcia, Oralia A; Mobley, Connie

    2004-09-01

    To evaluate the impact of a school-based diabetes mellitus prevention program on low-income fourth-grade Mexican American children. A randomized controlled trial with 13 intervention and 14 control schools. Elementary schools in inner-city neighborhoods in San Antonio, Tex. Eighty percent of participants were Mexican American and 94% were from economically disadvantaged households. Baseline and follow-up measures were collected from 1419 (713 intervention and 706 control) and 1221 (619 intervention and 602 control) fourth-grade children, respectively. The Bienestar Health Program consists of a health class and physical education curriculum, a family program, a school cafeteria program, and an after-school health club. The objectives are to decrease dietary saturated fat intake, increase dietary fiber intake, and increase physical activity. The primary end point was fasting capillary glucose level, and the secondary end points were percentage of body fat, physical fitness level, dietary fiber intake, and dietary saturated fat intake. Fasting capillary glucose level, bioelectric impedance, modified Harvard step test, three 24-hour dietary recalls, weight, and height were collected at baseline and 8 months later. Children in the intervention arm attended an average of 32 Bienestar sessions. Mean fasting capillary glucose levels decreased in intervention schools and increased in control schools after adjusting for covariates (-2.24 mg/dL [0.12 mmol/L]; 95% confidence interval, -6.53 to 2.05 [-0.36 to 0.11 mmol/L]; P =.03). Fitness scores (P =.04) and dietary fiber intake (P =.009) significantly increased in intervention children and decreased in control children. Percentage of body fat (P =.56) and dietary saturated fat intake (P =.52) did not differ significantly between intervention and control children. This intervention showed some positive results, but additional research is needed to examine long-term benefits, translation, and cost-effectiveness.

  12. CORRELATION OF THE SERUM LEVEL OF CARBAMAZEPINE WITH SEIZURE CONTROL AND ADVERSE DRUG REACTIONS AMONG EPILEPTICS IN IBADAN, NIGERIA

    Directory of Open Access Journals (Sweden)

    Joseph O. Fadare

    2010-12-01

    Full Text Available Background: Epilepsy is a chronic neurological disorder requiring long-term treatment. Seizure control requires adequate blood levels of anti-seizure drugs. Carbarmazepine is one of the most prescribed antiepileptic drugs in Nigeria. This study was carried out to investigate the correlation between serum levels of carbamazepine and seizure control and adverse drug reactions among epileptics in Ibadan, Nigeria. Methods: In a cross-sectional study, sixty-nine patients with confirmed diagnosis of epilepsy who had been on treatment with carbamazepine alone or in combination with phenytoin for at least one month were enrolled into the study and divided into two groups based on seizure control. Drug level in pre-dose (steady state venous blood was analyzed using high performance liquid chromatography. Result: The mean serum concentration of carbamazepine (CBZ and carbamazepine-epoxide (CBZ-EP was 13.5±9.3ìg/mL and 6.34±12.61ìg/mL respectively. Patients with good seizure control had mean serum CBZ concentration of 12.7 ± 9.2ìg/mL versus 15.02 ± 9.7ìg/mL among patients with poor seizure control (P=0.33. The serum concentration of CBZ-EP in patients with good seizure control was 8.05 ± 15.2ìg/mL while it was 3.11 ± 3.5ìg/mL in the second group (P=0.122. Drowsiness was the commonest adverse drug reaction (26.1% and it did not necessitate withdrawal of the drug. Conclusion The study showed that serum level of carbamazepine does not correlate with seizure control and adverse drug reactions.

  13. Development of Low Level RF Control Systems for Superconducting Heavy Ion Linear Accelerators, Electron Synchrotrons and Storage Rings

    CERN Document Server

    Aminov, Bachtior; Kolesov, Sergej; Pekeler, Michael; Piel, Christian; Piel, Helmut

    2005-01-01

    Since 2001 ACCEL Instruments is supplying low level RF control systems together with turn key cavity systems. The early LLRF systems used the well established technology based on discrete analogue amplitude and phase detectors and modulators. Today analogue LLRF systems can make use of advanced vector demodulators and modulators combined with a fast computer controlled analogue feed back loop. Feed forward control is implemented to operate the RF cavity in an open loop mode or to compensate for predictable perturbations. The paper will introduce the general design philosophy and show how it can be adapted to different tasks as controlling a synchrotron booster nc RF system at 500 MHz, or superconducting storage ring RF cavities, as well as a linear accelerator at 176 MHz formed by a chain of individually driven and controlled superconducting λ/2 cavities.

  14. Elevated levels of whole blood nickel in a group of Sri Lankan women with endometriosis: a case control study

    Directory of Open Access Journals (Sweden)

    Silva Nalinda

    2013-01-01

    Full Text Available Abstract Background Endometriosis is characterized by the persistence of endometrial tissue in ectopic sites outside the uterine cavity. Presence of nickel, cadmium and lead in ectopic endometrial tissue has been reported previously. While any association between blood levels of nickel and endometriosis is yet to be described in literature, conflicting reports are available with regards to cadmium and lead levels in blood and urine. Findings In fifty patients with endometriosis and fifty age-matched controls confirmed by laparoscopy or laparotomy, whole blood samples were collected and digested using supra pure 65% HNO3. Whole blood levels of nickel and lead were measured using Total Reflection X-ray Fluorescence (TXRF while cadmium levels were evaluated using graphite furnace atomic absorption spectroscopy (GFASS. Women with endometriosis had significantly higher (P=0.016 geometric mean (95% CI whole blood nickel levels [2.6(1.9-3.3 μg/L] as compared to women without endometriosis [0.8 (0.7-0.9 μg/L]. Whole blood levels of cadmium and lead were similar between the two groups. Conclusions Although women with endometriosis in this study population had higher levels of nickel in whole blood compared to controls, whether nickel could be considered as an aetiological factor in endometriosis remains inconclusive in view of the smaller sample that was evaluated.

  15. Back-to-back three-level converter controlled by a novel space-vector hysteresis current control for wind conversion systems

    Energy Technology Data Exchange (ETDEWEB)

    Ghennam, Tarak [Laboratoire d' Electronique de Puissance (LEP), UER: Electrotechnique, Ecole Militaire Polytechnique d' Alger, BP 17, Bordj EL Bahri, Alger (Algeria); Berkouk, El-Madjid [Laboratoire de Commande des Processus (LCP), Ecole Nationale Polytechnique d' Alger, BP 182, 10 avenue Hassen Badi, 16200 el Harrach (Algeria)

    2010-04-15

    In this paper, a novel space-vector hysteresis current control (SVHCC) is proposed for a back-to-back three-level converter which is used as an electronic interface in a wind conversion system. The proposed SVHCC controls the active and reactive powers delivered to the grid by the doubly fed induction machine (DFIM) through the control of its rotor currents. In addition, it controls the neutral point voltage by using the redundant inverter switching states. The three rotor current errors are gathered into a single space-vector quantity. The magnitude of the error vector is limited within boundary areas of a square shape. The control scheme is based firstly on the detection of the area and sector in which the vector tip of the current error can be located. Then, an appropriate voltage vector among the 27 voltage vectors of the three-level voltage source inverter (VSI) is applied to push the error vector towards the hysteresis boundaries. Simple look-up tables are required for the area and sector detection, and also for vector selection. The performance of the proposed control technique has been verified by simulations. (author)

  16. A Review of Modern Control Strategies for Clinical Evaluation of Propofol Anesthesia Administration Employing Hypnosis Level Regulation

    Science.gov (United States)

    Ilyas, Muhammad; Bilal, Muhammad; Mahmood, Khalid; Ali Riaz, Raja

    2017-01-01

    Regulating the depth of hypnosis during surgery is one of the major objectives of an anesthesia infusion system. Continuous administration of Propofol infusion during surgical procedures is essential but it unduly increases the load of an anesthetist working in a multitasking scenario in the operation theatre. Manual and target controlled infusion systems are not appropriate to handle instabilities like blood pressure and heart rate changes arising due to interpatient and intrapatient variability. Patient safety, large interindividual variability, and less postoperative effects are the main factors motivating automation in anesthesia administration. The idea of automated system for Propofol infusion excites control engineers to come up with more sophisticated systems that can handle optimum delivery of anesthetic drugs during surgery and avoid postoperative effects. A linear control technique is applied initially using three compartmental pharmacokinetic and pharmacodynamic models. Later on, sliding mode control and model predicative control achieve considerable results with nonlinear sigmoid model. Chattering and uncertainties are further improved by employing adaptive fuzzy control and H∞ control. The proposed sliding mode control scheme can easily handle the nonlinearities and achieve an optimum hypnosis level as compared to linear control schemes, hence preventing mishaps such as underdosing and overdosing of anesthesia. PMID:28466018

  17. A Review of Modern Control Strategies for Clinical Evaluation of Propofol Anesthesia Administration Employing Hypnosis Level Regulation

    Directory of Open Access Journals (Sweden)

    Muhammad Ilyas

    2017-01-01

    Full Text Available Regulating the depth of hypnosis during surgery is one of the major objectives of an anesthesia infusion system. Continuous administration of Propofol infusion during surgical procedures is essential but it unduly increases the load of an anesthetist working in a multitasking scenario in the operation theatre. Manual and target controlled infusion systems are not appropriate to handle instabilities like blood pressure and heart rate changes arising due to interpatient and intrapatient variability. Patient safety, large interindividual variability, and less postoperative effects are the main factors motivating automation in anesthesia administration. The idea of automated system for Propofol infusion excites control engineers to come up with more sophisticated systems that can handle optimum delivery of anesthetic drugs during surgery and avoid postoperative effects. A linear control technique is applied initially using three compartmental pharmacokinetic and pharmacodynamic models. Later on, sliding mode control and model predicative control achieve considerable results with nonlinear sigmoid model. Chattering and uncertainties are further improved by employing adaptive fuzzy control and H∞ control. The proposed sliding mode control scheme can easily handle the nonlinearities and achieve an optimum hypnosis level as compared to linear control schemes, hence preventing mishaps such as underdosing and overdosing of anesthesia.

  18. Restoring coastal wetlands that were ditched for mosquito control: a preliminary assessment of hydro-leveling as a restoration technique

    Science.gov (United States)

    Smith, Thomas J.; Tiling, Ginger; Leasure, Pamela S.

    2007-01-01

    The wetlands surrounding Tampa Bay, Florida were extensively ditched for mosquito control in the 1950s. Spoil from ditch construction was placed adjacent to the wetlands ditches creating mound-like features (spoil-mounds). These mounds represent a loss of 14% of the wetland area in Tampa Bay. Spoil mounds interfere with tidal flow and are locations for non-native plants to colonize (e.g., Schinus terebinthifolius). Removal of the spoil mounds to eliminate exotic plants, restore native vegetation, and re-establish natural hydrology is a restoration priority for environmental managers. Hydro-leveling, a new technique, was tested in a mangrove forest restoration project in 2004. Hydro-leveling uses a high pressure stream of water to wash sediment from the spoil mound into the adjacent wetland and ditch. To assess the effectiveness of this technique, we conducted vegetation surveys in areas that were hydro-leveled and in non-hydro-leveled areas 3 years post-project. Adult Schinus were reduced but not eliminated from hydro-leveled mounds. Schinus seedlings however were absent from hydro-leveled sites. Colonization by native species was sparse. Mangrove seedlings were essentially absent (≈2 m−2) from the centers of hydro-leveled mounds and were in low density on their edges (17 m−2) in comparison to surrounding mangrove forests (105 m−2). Hydro-leveling resulted in mortality of mangroves adjacent to the mounds being leveled. This was probably caused by burial of pneumatophores during the hydro-leveling process. For hydro-leveling to be a useful and successful restoration technique several requirements must be met. Spoil mounds must be lowered to the level of the surrounding wetlands. Spoil must be distributed further into the adjacent wetland to prevent burial of nearby native vegetation. Finally, native species may need to be planted on hydro-leveled areas to speed up the re-vegetation process.

  19. A Competency Model for Process Dynamics and Control and Its Use for Test Construction at University Level

    Science.gov (United States)

    Taskinen, Päivi H.; Steimel, Jochen; Gräfe, Linda; Engell, Sebastian; Frey, Andreas

    2015-01-01

    This study examined students' competencies in engineering education at the university level. First, we developed a competency model in one specific field of engineering: process dynamics and control. Then, the theoretical model was used as a frame to construct test items to measure students' competencies comprehensively. In the empirical…

  20. Thermal loading as a causal factor in exceeding the 0.1 PPM laboratory fume hood control level.

    Science.gov (United States)

    Chessin, Saul J; Johnston, James D

    2002-07-01

    Tracer gas testing per ANSI/ASHRAE 110-1995 Method of Testing Performance of Laboratory Fume Hoods was used to investigate the role of thermal loading in exceeding laboratory fume hood control levels. Three types of typical laboratory burners (blast, Meeker, and economy) were used to provide a thermal challenge. Heat outputs of between 0 and 61,610 Btu/hr were based on fuel heat capacity (for liquid propane gas) and fuel gas flow rates. Breathing zone concentrations were measured with a MIRAN 1B2 infrared gas analyzer. Also, for each test, the difference between the room and duct temperatures (delta temperature) was measured. Results indicated a linear relationship between heat loads and tracer gas breathing zone concentrations for both Btu/hr and delta temperature. Control levels of 0.1 ppm were exceeded at less than 12,000 Btu/hr. Also, control levels were exceeded at a lower heat load when the tracer gas generation rate was increased. These results indicate that thermal loads in laboratory fume hoods increase the risk of exceeding laboratory fume hood control levels. Some compensatory measures relative to hood configuration and flow rates are recommended for laboratory operations involving heat sources.

  1. The -148 C/T fibrinogen gene polymorphism and fibrinogen levels in ischaemic stroke: a case-control study

    NARCIS (Netherlands)

    M.P.J. van Goor (Marie-Louise); E.B. Gómez García (Encarna); F.W.G. Leebeek (Frank); G.J. Brouwers (Geert Jan); P.J. Koudstaal (Peter Jan); D.W.J. Dippel (Diederik)

    2005-01-01

    textabstractBACKGROUND: To determine whether -148 C/T fibrinogen gene promoter polymorphism increases stroke risk by modifying the fibrinogen level. DESIGN: A case-control study of patients with first ever ischaemic stroke, confirmed by computed tomography. METHODS: Venous blood samples were

  2. Theory of Mind and Executive Control Deficits in Typically Developing Adults and Adolescents with High Levels of Autism Traits

    Science.gov (United States)

    Gökçen, Elif; Frederickson, Norah; Petrides, K. V.

    2016-01-01

    Autism spectrum disorder (ASD) is characterised by profound difficulties in empathic processing and executive control. Whilst the links between these processes have been frequently investigated in populations with autism, few studies have examined them at the subclinical level. In addition, the contribution of alexithymia, a trait characterised by…

  3. Theory of Mind and Executive Control Deficits in Typically Developing Adults and Adolescents with High Levels of Autism Traits

    Science.gov (United States)

    Gökçen, Elif; Frederickson, Norah; Petrides, K. V.

    2016-01-01

    Autism spectrum disorder (ASD) is characterised by profound difficulties in empathic processing and executive control. Whilst the links between these processes have been frequently investigated in populations with autism, few studies have examined them at the subclinical level. In addition, the contribution of alexithymia, a trait characterised by…

  4. Design of Three-Phase Three-Level CIC T-Source Inverter with Maximum Boost Control

    DEFF Research Database (Denmark)

    Shults, Tatiana; Husev, Oleksandr; Roncero-Clemente, Carlos

    2015-01-01

    This paper presents guidelines for component design of the three-level three-phase T-source inverter with continuous input current under maximum boost control proposed recently. Steady state analysis under low-frequency current and voltage ripples in the dc side was made. Component sizes for both...

  5. Levels of platelet-derived microparticles and soluble p-selectin in patients of acute myocardial infarction (case control study).

    Science.gov (United States)

    Hameed, Aisha; Rubab, Zille; Abbas Rizvi, Syed Khizar; Hussain, Shabbir; Latif, Waqas; Mohsin, Shahida

    2017-07-01

    TTo measure levels of platelet-derived microparticles and soluble P-selectin in patients of acute myocardial infarction and their comparison with healthy controls. This case-control study was conducted in Department of Haematology, University of Health Sciences Lahore from April to September 2013, and comprised patients of acute myocardial infarction in group 1 and healthy controls in group 2. Platelet-derived microparticles and soluble P-selectin were measured by enzyme-linked immunosorbent assay. SPSS21 was used for data analysis. Of the 80 participants, 50(62.5%) were patients and 30(37.5%) were controls. The mean levels of platelet-derived microparticles and soluble P-selectin were significantly higher in group 1 compared to group 2 (45.70±10.30 vs 10.60±0.96, and 51.46±9.30 vs 9.16±1.04, respectively) (pP-selectin in three intervals after acute myocardial infarction (p>0.05). Although levels of platelet-derived microparticles and soluble P-selectin did not correlate to creatinekinase-myocardial band levels (p>0.05), but there was a trend of significant correlation with cardiac troponin T (pP-selectin can be used as novel early diagnostic marker of acute myocardial infarction.

  6. The Harm Principle as a Mid-level Principle? Three Problems from the Context of Infectious Disease Control

    NARCIS (Netherlands)

    Krom, A.

    2011-01-01

    Effective infectious disease control may require states to restrict the liberty of individuals. Since preventing harm to others is almost universally accepted as a legitimate (prima facie) reason for restricting the liberty of individuals, it seems plausible to employ a mid-level harm principle in i

  7. The use of low-level laser therapy for controlling the gag reflex in children during intraoral radiography.

    Science.gov (United States)

    Elbay, Mesut; Tak, Önjen; Şermet Elbay, Ülkü; Kaya, Can; Eryılmaz, Kubilay

    2016-02-01

    The current literature suggests that low-level laser stimulation of the PC 6 acupuncture points may prevent gagging. This study aimed to determine if low-level laser therapy (LLLT) can reduce the gag reflex in children undergoing intraoral maxillary radiography. This randomized, controlled, double-blind clinical trial was conducted with 25 children with moderate-to-very severe gag reflexes who required bilateral periapical radiographic examination of the maxillary molar region. Children's anxiety levels were initially evaluated using Corah's Dental Anxiety Scale (DAS) to identify any possible relationship between gagging and anxiety. A control radiograph was taken of one randomly selected side in each patient after simulated laser application so that the patient was blinded to the experimental conditions (control group). Laser stimulation was then performed for the experimental side. A laser probe was placed on the Pericardium 6 (PC 6) acupuncture point on each wrist, and laser energy was delivered for 14 s (300 mW, energy density 4 J/cm(2)) at a distance of 1 cm from the target tissue. Following laser stimulation, the experimental radiograph was taken (experimental group). Gagging responses were measured using the Gagging Severity Criteria for each group. Data were analyzed using Spearman's rho correlations and Mann-Whitney U tests. Both mean and median gagging scores were higher in the control group than in the experimental group. Patients who were unable to tolerate the intraoral control radiography were able to tolerate the procedure after LLLT. Differences between gagging scores of the control and experimental groups were statistically significant (P = .000). There was no significant correlation between gagging severity and anxiety score (P > .05). A negative correlation was found between age and gagging score in the control group (P ˂ .05). Within the limitations of this study, LLLT of the PC 6 acupuncture points appears to be a useful technique

  8. Energy evaluation of low-level control in UAVs powered by lithium polymer battery.

    Science.gov (United States)

    Gandolfo, Daniel C; Salinas, Lucio R; Serrano, Mario E; Toibero, Juan M

    2017-08-31

    Nowadays, the energetic cost of flying in electric-powered UAVs is one of the key challenges. The continuous evolution of electrical energy storage sources is overcome by the great amount of energy required by the propulsion system. Therefore, the on-board energy is a crucial factor that needs to be further analyzed. In this work, different control strategies applied to a generic UAV propulsion system are considered and a lithium polymer battery dynamic model is included as the propulsion system energy source. Several simulations are carried out for each control strategy, and a quantitative evaluation of the influence of each control law over the actual energy consumed by the propulsion system is reported. This energy, which is delivery by the battery, is next compared against a well-known control-effort-based index. The results and analysis suggest that conclusions regarding energy savings based on control effort signals should be drawn carefully, because they do not directly represent the actual consumed energy. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  9. Fast quantum control and light-matter interactions at the 10,000 quanta level

    CERN Document Server

    Alonso, J; Soler, Z U; Fadel, M; Marinelli, M; Keitch, B C; Negnevitsky, V; Home, J P

    2015-01-01

    Fast control of quantum systems is essential in order to make use of quantum properties before they are degraded by decoherence. This is important for quantum-enhanced information processing, as well as for pushing quantum systems into macroscopic regimes at the boundary between quantum and classical physics. Bang-bang control attains the ultimate speed limit by making large changes to control fields on timescales much faster than the system can respond, however these methods are often challenging to implement experimentally. Here we demonstrate bang-bang control of a trapped-ion oscillator using nano-second switching of the trapping potentials. We perform controlled displacements which allow us to realize quantum states with up to 10,000 quanta of energy. We use these displaced states to verify the form of the ion-light interaction at high excitations which are far outside the usual regime of operation. These methods provide new possibilities for quantum-state manipulation and generation, alongside the poten...

  10. A new phase in the production of quality-controlled sea level data

    Science.gov (United States)

    Quartly, Graham D.; Legeais, Jean-François; Ablain, Michaël; Zawadzki, Lionel; Joana Fernandes, M.; Rudenko, Sergei; Carrère, Loren; Nilo García, Pablo; Cipollini, Paolo; Andersen, Ole B.; Poisson, Jean-Christophe; Mbajon Njiche, Sabrina; Cazenave, Anny; Benveniste, Jérôme

    2017-08-01

    Sea level is an essential climate variable (ECV) that has a direct effect on many people through inundations of coastal areas, and it is also a clear indicator of climate changes due to external forcing factors and internal climate variability. Regional patterns of sea level change inform us on ocean circulation variations in response to natural climate modes such as El Niño and the Pacific Decadal Oscillation, and anthropogenic forcing. Comparing numerical climate models to a consistent set of observations enables us to assess the performance of these models and help us to understand and predict these phenomena, and thereby alleviate some of the environmental conditions associated with them. All such studies rely on the existence of long-term consistent high-accuracy datasets of sea level. The Climate Change Initiative (CCI) of the European Space Agency was established in 2010 to provide improved time series of some ECVs, including sea level, with the purpose of providing such data openly to all to enable the widest possible utilisation of such data. Now in its second phase, the Sea Level CCI project (SL_cci) merges data from nine different altimeter missions in a clear, consistent and well-documented manner, selecting the most appropriate satellite orbits and geophysical corrections in order to further reduce the error budget. This paper summarises the corrections required, the provenance of corrections and the evaluation of options that have been adopted for the recently released v2.0 dataset (https://doi.org/10.5270/esa-sea_level_cci-1993_2015-v_2.0-201612" target="_blank">https://doi.org/10.5270/esa-sea_level_cci-1993_2015-v_2.0-201612). This information enables scientists and other users to clearly understand which corrections have been applied and their effects on the sea level dataset. The overall result of these changes is that the rate of rise of global mean sea level (GMSL) still equates to ˜ 3.2 mm yr-1 during 1992-2015, but there is now greater

  11. Top-down models in biology: explanation and control of complex living systems above the molecular level.

    Science.gov (United States)

    Pezzulo, Giovanni; Levin, Michael

    2016-11-01

    It is widely assumed in developmental biology and bioengineering that optimal understanding and control of complex living systems follows from models of molecular events. The success of reductionism has overshadowed attempts at top-down models and control policies in biological systems. However, other fields, including physics, engineering and neuroscience, have successfully used the explanations and models at higher levels of organization, including least-action principles in physics and control-theoretic models in computational neuroscience. Exploiting the dynamic regulation of pattern formation in embryogenesis and regeneration requires new approaches to understand how cells cooperate towards large-scale anatomical goal states. Here, we argue that top-down models of pattern homeostasis serve as proof of principle for extending the current paradigm beyond emergence and molecule-level rules. We define top-down control in a biological context, discuss the examples of how cognitive neuroscience and physics exploit these strategies, and illustrate areas in which they may offer significant advantages as complements to the mainstream paradigm. By targeting system controls at multiple levels of organization and demystifying goal-directed (cybernetic) processes, top-down strategies represent a roadmap for using the deep insights of other fields for transformative advances in regenerative medicine and systems bioengineering.

  12. Obsessive-Compulsive Symptomatology, Religiosity Levels and the Illusion-of-Control Paradigm in a Non-Clinical Undergraduate Sample.

    Science.gov (United States)

    Vassiliou, Andreas

    2015-10-01

    The present research employed the illusion-of-control paradigm to investigate the relationships between Obsessive-Compulsive disorder (OCD) symptoms, religiosity levels, and illusory sense of control (SC). An opportunistic sample of 60 undergraduate students was presented with a pre-programmed series of neutral visual stimuli (i.e. lines) and was expected to try to control the sequence through the use of keyboard presses. Participants assessed their perceived level of control twice throughout the computerised task. In addition, the study was interested at examining the relationship between religiosity and OC behaviour and the Santa Clara Strength of Religious Faith Questionnaire (SCSRF) was employed. In proportion to predictions, OCD symptoms were correlated with higher illusory SC; furthermore, religiosity levels were related to some degree to OCD symptoms. The essential role of mental control in OCD is discussed, particularly the significant clinical implications of such an association. Furthermore, the possible contribution of religious affiliations to the maintenance of OC behaviour is further discussed.

  13. Top-down models in biology: explanation and control of complex living systems above the molecular level

    Science.gov (United States)

    2016-01-01

    It is widely assumed in developmental biology and bioengineering that optimal understanding and control of complex living systems follows from models of molecular events. The success of reductionism has overshadowed attempts at top-down models and control policies in biological systems. However, other fields, including physics, engineering and neuroscience, have successfully used the explanations and models at higher levels of organization, including least-action principles in physics and control-theoretic models in computational neuroscience. Exploiting the dynamic regulation of pattern formation in embryogenesis and regeneration requires new approaches to understand how cells cooperate towards large-scale anatomical goal states. Here, we argue that top-down models of pattern homeostasis serve as proof of principle for extending the current paradigm beyond emergence and molecule-level rules. We define top-down control in a biological context, discuss the examples of how cognitive neuroscience and physics exploit these strategies, and illustrate areas in which they may offer significant advantages as complements to the mainstream paradigm. By targeting system controls at multiple levels of organization and demystifying goal-directed (cybernetic) processes, top-down strategies represent a roadmap for using the deep insights of other fields for transformative advances in regenerative medicine and systems bioengineering. PMID:27807271

  14. Effects of Gentle Human Touch and Field Massage on Urine Cortisol Level in Premature Infants: A Randomized, Controlled Clinical Trial

    Science.gov (United States)

    Asadollahi, Malihe; Jabraeili, Mahnaz; Mahallei, Majid; Asgari Jafarabadi, Mohammad; Ebrahimi, Sakine

    2016-01-01

    Introduction: Hospitalization in neonatal intensive care unit may leads to many stresses for premature infants. Since premature infants cannot properly process stressors, identifying interventions that reduce the stress level for them is seems necessary. The aim of present study was to compare the effects of Field massage and Gentle Human Touch (GHT) techniques on the urine level of cortisol, as an indicator of stress in preterm infants. Methods: This randomized, controlled clinical trial was carried out in Al-Zahra hospital, Tabriz. A total of 84 premature infants were randomly assigned into three groups. First groups were touched by their mothers three times a day (15 minutes in each session) for 5 days by GHT technique. The second group was received 15 minutes Field massage with sunflower oil three times a day by their mothers for 5 days. The third group received routine care. In all groups, 24-hours urine samples were collected in the first and sixth day after the intervention and analyzed for cortisol level. Data were analyzed by SPSS software. Results: There were significant differences between mean of changes in cortisol level between GHT and control groups and Field massage and control groups (0.026). Conclusion: Although the massage with Field technique resulted in a significant reduction in blood cortisol level, but the GHT technique have also a similar effect. So, both methods are recommended for decreasing of stress in preterm infants. PMID:27752484

  15. Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control

    Directory of Open Access Journals (Sweden)

    Atqah Abdul Wahab

    2013-01-01

    Full Text Available There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA and nonobese asthmatic (NOA children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and analyzed. Serum leptin was significantly higher (25.8±11.1 versus 8.7±11.1; P<0.0001 and adiponectin levels were lower (2.5±1.2 versus 5.4±2.9; P<0.0001 in OA compared to NOA children. The uncontrolled group had higher leptin and lower adiponectin levels compared to well and partially controlled asthma. BMI was positively correlated with leptin (r=0.79; P<0.001 and negatively with adiponectin (r=-0.73; P<0.001. Mean BMI and leptin levels were observed to be higher in girls compared to boys. Stepwise multiple linear regression analysis showed that higher BMI and female gender had significant effect on serum leptin levels. Among asthmatic children higher serum leptin and lower adiponectin levels were significantly associated with obesity and showed no significant association with degree of asthma controls.

  16. Advances in quantum control of three-level superconducting circuit architectures

    Energy Technology Data Exchange (ETDEWEB)

    Falci, G.; Paladino, E. [Dipartimento di Fisica e Astronomia, Universita di Catania (Italy); CNR-IMM UOS Universita (MATIS), Consiglio Nazionale delle Ricerche, Catania (Italy); INFN, Sezione di Catania (Italy); Di Stefano, P.G. [Dipartimento di Fisica e Astronomia, Universita di Catania (Italy); Centre for Theoretical Atomic, Molecular and Optical Physics, School of Mathematics and Physics, Queen' s University Belfast(United Kingdom); Ridolfo, A.; D' Arrigo, A. [Dipartimento di Fisica e Astronomia, Universita di Catania (Italy); Paraoanu, G.S. [Low Temperature Laboratory, Department of Applied Physics, Aalto University School of Science (Finland)

    2017-06-15

    Advanced control in Lambda (Λ) scheme of a solid state architecture of artificial atoms and quantized modes would allow the translation to the solid-state realm of a whole class of phenomena from quantum optics, thus exploiting new physics emerging in larger integrated quantum networks and for stronger couplings. However control solid-state devices has constraints coming from selection rules, due to symmetries which on the other hand yield protection from decoherence, and from design issues, for instance that coupling to microwave cavities is not directly switchable. We present two new schemes for the Λ-STIRAP control problem with the constraint of one or two classical driving fields being always-on. We show how these protocols are converted to apply to circuit-QED architectures. We finally illustrate an application to coherent spectroscopy of the so called ultrastrong atom-cavity coupling regime. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. Theory of Mind in Schizophrenia: Associations With Clinical and Cognitive Insight Controlling for Levels of Psychopathology.

    Science.gov (United States)

    Popolo, Raffaele; Dimaggio, Giancarlo; Luther, Lauren; Vinci, Giancarlo; Salvatore, Giampaolo; Lysaker, Paul H

    2016-03-01

    Poor insight in schizophrenia is a risk factor for both poor outcomes and treatment adherence. Accordingly, interest in identifying causes of poor insight has increased. This study explored whether theory of mind (ToM) impairments are linked to poor clinical and cognitive insight independent of psychopathology. Participants with schizophrenia (n = 37) and control subjects (n = 40) completed assessments of ToM with the Hinting Task and the Brüne Picture Sequencing Task, clinical insight and psychopathology with the Positive and Negative Syndrome Scale, and cognitive insight with the Beck Cognitive Insight Scale. Results indicated that the schizophrenia group had greater impairments in ToM relative to control subjects. In the schizophrenia group, the Hinting Task performance was related to both cognitive and clinical insight, with only the relationship with cognitive insight persisting after controlling for psychopathology. Picture Sequencing Task performance was related to cognitive insight only. Future research directions and clinical implications are discussed.

  18. The effects of level of knowledge upon human problem solving in a process control task

    Science.gov (United States)

    Morris, N. M.; Rouse, W. B.

    1983-01-01

    The effect of knowledge of a system on the performance of the operator has been investigated using PLANT, a generic simulation of a process. Four sets of written instructions representing the what, how, and why of system control were utilized by groups of subjects who controlled PLANT in a variety of familiar and unfamiliar situations. Written test results at the end of the experiments showed that the instructions had no effect on the primary goal of production, but those groups receiving guidelines for operation (the how) controlled the system in a more stable manner. Principles (the why) had no apparent effect on the subjects' performance. There was no difference between groups in diagnosing unfamiliar events.

  19. A real-time human-perception interface for task-level control of a robot in unfamiliar environments

    Science.gov (United States)

    Miles, Eric Scott

    Recent advances in the development of semi-autonomous robotic systems offer numerous potential advantages in many engineering and science endeavors. Significant reductions in cost, time and risk, as well as increased capability, can be obtained by utilizing intelligent machines to assist humans. However, the use of robots also introduces many challenging issues, including the need for high-bandwidth stable control despite communication delays and operator fatigue. In response to these challenges, the Stanford Aerospace Robotics Laboratory has pioneered the Task-Level Control architecture, which enables humans to direct, from a strategic level, sophisticated tasks that a robot then executes autonomously. The research reported here is intended to extend the Task-Level Control architecture significantly--by using human perception in a natural way--to work well in unfamiliar environments. An unfamiliar environment is defined to be one about which it is impossible to have perfect and complete knowledge before developing and deploying a robotic system. Clearly, every work environment is, to some extent, unfamiliar. This research has shown that drawing intimately, in real time, upon a human's deep visual perception is extremely effective in overcoming such unfamiliarity. A novel interactive vision-based operator interface for directing a highly autonomous robot operating in an unfamiliar environment is presented. Intuitive interaction with a live-video display from cameras on board the robot is used in combination with stereo-vision algorithms to maintain the operator's attention at the overall object-level during the modeling process. With this interface, the human's remarkable ability to discern entire object-level constructs is utilized to produce quick, cogent and robust models of unexpected and unknown objects in the environment. Once unfamiliar objects have been suitably modeled, tasks involving those objects can be directed via the Task-Level Control architecture

  20. The effect of a motivational intervention on weight loss is moderated by level of baseline controlled motivation

    Directory of Open Access Journals (Sweden)

    Tate Deborah F

    2010-01-01

    Full Text Available Abstract Background Clinic-based behavioral weight loss programs are effective in producing significant weight loss. A one-size-fits-all approach is often taken with these programs. It may be beneficial to tailor programs based on participants' baseline characteristics. Type and level of motivation may be an important factor to consider. Previous research has found that, in general, higher levels of controlled motivation are detrimental to behavior change while higher levels of autonomous motivation improve the likelihood of behavior modification. Methods This study assessed the outcomes of two internet behavioral weight loss interventions and assessed the effect of baseline motivation levels on program success. Eighty females (M (SD age 48.7 (10.6 years; BMI 32.0 (3.7 kg/m2; 91% Caucasian were randomized to one of two groups, a standard group or a motivation-enhanced group. Both received a 16-week internet behavioral weight loss program and attended an initial and a four-week group session. Weight and motivation were measured at baseline, four and 16 weeks. Hierarchical regression analysis was conducted to test for moderation. Results There was significant weight loss at 16-weeks in both groups (p p = 0.57 (standard group 3.4 (3.6 kg; motivation-enhanced group 3.9 (3.4 kg. Further analysis was conducted to examine predictors of weight loss. Baseline controlled motivation level was negatively correlated with weight loss in the entire sample (r = -0.30; p = 0.01. Statistical analysis revealed an interaction between study group assignment and baseline level of controlled motivation. Weight loss was not predicted by baseline level of controlled motivation in the motivation-enhanced group, but was significantly predicted by controlled motivation in the standard group. Baseline autonomous motivation did not predict weight change in either group. Conclusions This research found that, in participants with high levels of baseline controlled motivation