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Sample records for preheating ablation effects

  1. Effect of preheating on potato texture.

    Science.gov (United States)

    Andersson, A; Gekas, V; Lind, I; Oliveira, F; Oste, R

    1994-01-01

    Preheating potatoes at 50 to 80 degrees C has a firming effect on the cooked potato tissue. This effect is particularly pronounced at a preheating temperature of 60 to 70 degrees C followed by cooling. Several theories have been presented in the literature to explain this firming effect: retrogradation of starch, leaching of amylose, stabilization of the middle lamellae and cell walls by the activation of the pectin methylesterase (PME) enzyme, and by the release of calcium from gelatinized starch and the formation of calcium bridges between pectin molecules. Most probably, none of these theories alone can explain the phenomenon and more than one mechanism seems to be involved. Some of these mechanisms seem to be interdependent. As an example, calcium could be considered as a link all the way through release after starch gelatinization to cross-linking pectin substances in the cell wall and the middle lamellae, which has been demethylated by the PME enzyme. More research and "clear cut" experiments are needed in order to elucidate the role of each mechanism, especially which of them is the main contributor to the process of firming. Most probably, the calcium-pectin-PME mechanism plays a secondary role, that is, it only retards the collapse of the tissue structure that would otherwise occur during the final heating without preheating, and it is not the main factor of firmness.

  2. Effect of pre-heating on the viscosity and microhardness of a resin composite.

    LENUS (Irish Health Repository)

    Lucey, S

    2010-04-01

    The effect of pre-heating resin composite on pre-cured viscosity and post-cured surface hardness was evaluated. Groups of uncured specimens were heated to 60 degrees C and compared with control groups (24 degrees C) with respect to viscosity and surface hardness. Mean (SD) viscosities of the pre-heated specimens (n = 15) were in the range of 285 (13)-377 (11) (Pa) compared with 642 (35)-800 (23) (Pa) at ambient temperature. There was a statistically significant difference between the two groups (P < 0.001). Mean (SD) Vickers microhardness (VHN) of the pre-heated group (n = 15) was 68.6 (2.3) for the top surface and 68.7 (1.8) for the bottom surface measured at 24 h post curing (specimen thickness = 1.5 mm). The corresponding values for the room temperature group were 60.6 (1.4) and 59.0 (3.5). There was a statistically significant difference between corresponding measurements taken at the top and bottom for the pre-heated and room temperature groups (P < 0.001). There was no significant difference between top and bottom measurements within each group. Pre-heating resin composite reduces its pre-cured viscosity and enhances its subsequent surface hardness. These effects may translate as easier placement together with an increased degree of polymerization and depth-of-cure.

  3. Effect of preheating on the viscoelastic properties of dental composite under different deformation conditions.

    Science.gov (United States)

    Ahn, Kyung Hyun; Lim, Sanghyuk; Kum, Kee Yeon; Chang, Seok Woo

    2015-01-01

    Preheating of dental composites improves their flowability, facilitating successful restorations. However, the flowability of dental composites is affected not only by temperature but also by the deformation conditions. In the present work, the effects of various deformation conditions upon the viscoelastic properties of a preheated dental composite were studied. The rheological properties of Z350 dental composites at 25, 45, and 60°C were measured by a strain-controlled rheometer. When a low strain (0.03%) was applied, the preheated composite exhibited greater shear storage modulus (G') and complex viscosity (η*) than a room-temperature composite. Oppositely, when a high strain (50%) was applied, G' and η* of a preheated composite were lower than those of a room-temperature composite. Preheating of dental composites might be helpful in clinical practice both to increase the slumping resistance when minimal manipulation is used (e.g., during the build-up of a missing cusp tip) and to increase flowability when manipulation entailing high shear strain is applied (e.g., when uncured composite resin is spread on a dentin surface).

  4. Effect of pre-heating on hardness of methacrylate- and silorane-based composites

    OpenAIRE

    Catelan, Anderson; Barreto,Bruno; Lima, Adriano; Oliveira, Marcelo; Marchi, Giselle; Aguiar, Flávio

    2014-01-01

    AIM: To evaluate the effect of composite pre-heating on the microhardness of different monomer resin-based. MATERIALS AND METHOD: Circular specimens of methacrylate- and silorane-based composite resins pre-heated at 23, 39, and 55˚ C were carried out, and cured using a halogen light-curing unit at 650 mW/cm². After 24 h, the specimens were polished and Knoop hardness number (KHN) was measured using a microhardness tester with 50-g load for 15 s. The data were analyzed with ANOVA and Tukey’s t...

  5. Effect of pre-heating on the mechanical properties of silorane-based and methacrylate-based composites

    Science.gov (United States)

    Mohammadi, Narmin; Jafari-Navimipour, Elmira; Kimyai, Soodabeh; Ajami, Amir-Ahmad; Bahari, Mahmoud; Ansarin, Mohammad

    2016-01-01

    Background The use of composites in dental restoration has been commonly criticized, due to their underwhelming mechanical properties. This problem may be solved partially by preheating. The present research aims to determine the effect of preheating on the mechanical properties of two different classes of composites. Material and Methods A Silorane-based (Silorane) and a Methacrylate-based (Z250) composite were preheated to different temperatures (25, 37, and 68 °C) and afterwards were tested with the appropriate devices for each testing protocol. The material’s flexural strength, elastic modulus, and Vickers microhardness were evaluated. Two-way ANOVA, and Tukey’s post hoc were used to analyze the data. Results Microhardness and elastic modulus increased with preheating, while flexural strength values did not increase significantly with preheating. Furthermore the methacrylate-based composite (Z250) showed higher values compared to the Silorane-based composite (Silorane) in all the tested properties. Conclusions Preheating Silorane enhances the composite’s microhardness and elastic modulus but does not affect its flexural strength. On the other hand, preheating Z250 increases its microhardness but does not change its flexural strength or elastic modulus. In addition, the Z250 composite shows higher microhardness and flexural strength than Silorane, but the elastic modulus values with preheating are similar. Therefore Z250 seems to have better mechanical properties making it the better choice in a clinical situation. Key words:Composite, elastic modulus, flexural strength, microhardness, preheating. PMID:27703604

  6. Effects of Preheated Composite on Micro leakage-An in-vitro Study

    Science.gov (United States)

    Raj, James David; Sherlin, Herald

    2016-01-01

    Introduction Resin composites have been the pinnacle of direct esthetic restorations ever since its discovery. However, it comes with its own disadvantages. Post-operative sensitivity and marginal discoloration frequently occur due to polymerization shrinkage and micro leakage, which is the major cause of failure in resin composite restorations. Aim To evaluate the effects of preheated composite at different temperatures on microleakage. Materials and Methods A total of 60 extracted non-carious human premolars were collected and class 1 cavity (1.5x4x 3mm) was prepared in each and were randomly divided into three groups. Group 1 (n=20) was filled with microhybrid resin composite (Heraeus Charisma Smile) at room temperature. Group 2 (n=20) was filled with the same resin composite which was preheated to 50°C and Group 3 (n=20) was filled with resin composite preheated to 60°C. Teeth were subjected to a thermocycling regime (500X, 5 - 55°C), followed by a dye infiltration by immersing in basic fuschin for 24 hours. The tooth was sectioned longitudinally and the extent or absence of micro-leakage was determined by the amount of dye penetration along the resin composite-tooth interface using a confocal microscope. Results There was minor micro-leakage detected at the occlusal margin of the control tooth specimen. The sample with preheated composite restoration at 50°C showed an intact tooth-restoration interface with no micro leakage. However, the preheated composite at 60°C showed large amount of microleakage. Conclusion Under the current limitation of the study, preheated composite at 50°C showed the least micro-leakage. PMID:27504407

  7. Effect of Preheating in Hybrid Friction Stir Welding of Aluminum Alloy

    Science.gov (United States)

    Yaduwanshi, D. K.; Bag, S.; Pal, S.

    2014-10-01

    The controlled energy input into the system by introducing an extra heat source to enhance the material flow along with reduction of the plunging force remains a potential area of considerate for the development of hybrid friction stir welding (FSW) process. Hence, the effect of preheating on the weld joint properties is evaluated using plasma-assisted friction stir welding (P-FSW) process for joining aluminum alloy. A comparative study of mechanical and macro-microstructural characterizations of weld joint by FSW and P-FSW has been performed. Transverse tensile strength of weld joint is approximately 95% of base metal produced by P-FSW and is 8% more than conventional FSW welds. The effect of preheating enhances material flow and dissolution of fine oxide particles by plasma arc results in increase of strength and marginal modification of deformation behavior. The preheating brings uniformly distributed hardness in weld zone and the magnitude is higher in the advancing side with overall increase in average hardness value. Grain sizes are much finer due to the pinning effect of Al2O3 particles that retarded grain growth following recrystallization during P-FSW and thus led to more pronounced reduction in grain size and relatively brittle fracture during tensile loading of welded joint. Overall, the influence of preheating acts quite homogeneously throughout the structure as compared to conventional FSW. However, the results reveal that the development of P-FSW is still in initial stage and needs to improve in various aspects.

  8. Effect of preheating and light-curing unit on physicochemical properties of a bulk fill composite.

    Science.gov (United States)

    Theobaldo, Jéssica Dias; Aguiar, Flávio Henrique Baggio; Pini, Núbia Inocencya Pavesi; Lima, Débora Alves Nunes Leite; Liporoni, Priscila Christiane Suzy; Catelan, Anderson

    2017-01-01

    The aim of this study is to evaluate the effect of composite preheating and polymerization mode on degree of conversion (DC), microhardness (KHN), plasticization (P), and depth of polymerization (DP) of a bulk fill composite. Forty disc-shaped samples (n = 5) of a bulk fill composite were prepared (5 × 4 mm thick) and randomly divided into 4 groups according to light-curing unit (quartz-tungsten-halogen [QTH] or light-emitting diode [LED]) and preheating temperature (23 or 54 °C). A control group was prepared with a flowable composite at room temperature. DC was determined using a Fourier transform infrared spectrometer, KHN was measured with a Knoop indenter, P was evaluated by percentage reduction of hardness after 24 h of ethanol storage, and DP was obtained by bottom/top ratio. Data were statistically analyzed by analysis of variance and Tukey's test (α = 0.05). Regardless of light-curing, the highest preheating temperature increased DC compared to room temperature on bottom surface. LED showed a higher DC compared to QTH. Overall, DC was higher on top surface than bottom. KHN, P, and DP were not affected by curing mode and temperature, and flowable composite showed similar KHN, and lower DC and P, compared to bulk fill. Composite preheating increased the polymerization degree of 4-mm-increment bulk fill, but it led to a higher plasticization compared to the conventional flowable composite evaluated.

  9. Effect of preheating on the film thickness of contemporary composite restorative materials

    OpenAIRE

    Dimitrios Dionysopoulos; Kosmas Tolidis; Paris Gerasimou; Eugenia Koliniotou-Koumpia

    2014-01-01

    Background/purpose: Recently, the placement of composite materials at an elevated temperature has been proposed in order to increase their flow for better adaptation in cavity walls. The aim of this in vitro study was to evaluate the effect of preheating on the film thickness of a variety of commercially available conventional composites and to compare them with those obtained from a variety of flowable composites at room temperature. Materials and methods: The composites were three nanohy...

  10. Effect of Combustion Air Pre-Heating In Carbon Monoxide Emission in Diesel Fired Heat Treatment Furnace

    Directory of Open Access Journals (Sweden)

    E B Muhammed Shafi,

    2015-09-01

    Full Text Available This paper describes the effect of combustion air pre- heating in Diesel fired heat Treatment Furnace. The main heat treatment processes are Normalizing, Tempering, Hardening, Annealing, Solution Annealing and Stress Relieving. The emission of carbon monoxide is measured with combustion air pre-heating and without preheating. The results are then compared and it is found that the emission of CO is reduced by 29.12%. With the Combustion air pre-heating a considerable reduction in Specific Furnace Fuel Consumption (SFFC is obtained. The test was caaried out at Peekay Steels Casting (P ltd, Nallalam, Calicut.

  11. Effect of preheating and light-curing unit on physicochemical properties of a bulk fill composite

    Directory of Open Access Journals (Sweden)

    Theobaldo JD

    2017-05-01

    Full Text Available Jéssica Dias Theobaldo,1 Flávio Henrique Baggio Aguiar,1 Núbia Inocencya Pavesi Pini,2 Débora Alves Nunes Leite Lima,1 Priscila Christiane Suzy Liporoni,3 Anderson Catelan3 1Department of Restorative Dentistry, Piracicaba Dental School, University of Campinas, Piracicaba, 2Ingá University Center, Maringá, 3Departament of Dentistry, University of Taubaté, Taubaté, Brazil Objective: The aim of this study is to evaluate the effect of composite preheating and polymerization mode on degree of conversion (DC, microhardness (KHN, plasticization (P, and depth of polymerization (DP of a bulk fill composite.Methods: Forty disc-shaped samples (n = 5 of a bulk fill composite were prepared (5 × 4 mm thick and randomly divided into 4 groups according to light-curing unit (quartz–tungsten–halogen [QTH] or light-emitting diode [LED] and preheating temperature (23 or 54 °C. A control group was prepared with a flowable composite at room temperature. DC was determined using a Fourier transform infrared spectrometer, KHN was measured with a Knoop indenter, P was evaluated by percentage reduction of hardness after 24 h of ethanol storage, and DP was obtained by bottom/top ratio. Data were statistically analyzed by analysis of variance and Tukey’s test (α = 0.05.Results: Regardless of light-curing, the highest preheating temperature increased DC compared to room temperature on bottom surface. LED showed a higher DC compared to QTH. Overall, DC was higher on top surface than bottom. KHN, P, and DP were not affected by curing mode and temperature, and flowable composite showed similar KHN, and lower DC and P, compared to bulk fill.Conclusion: Composite preheating increased the polymerization degree of 4-mm-increment bulk fill, but it led to a higher plasticization compared to the conventional flowable composite evaluated. Keywords: composite resins, physicochemical phenomena, polymerization, hardness, heating

  12. The effect of preheating and opacity on the sorption and solubility of a composite resin.

    Science.gov (United States)

    Castro, Fabrício Luscino Alves de; Pazinatto, Flávia Bittencourt; de Lima, Érick; Cesar, Paulo Francisco; Reges, Rogério Vieira

    2016-01-01

    This study evaluated the influence of material opacity and preheating on the sorption and solubility of a composite resin material. A commercially available composite resin and an 8 × 2-mm circular metallic matrix were used to fabricate a total of 60 specimens in 6 shades, of which 3 had conventional opacity (CA2, CA3, and CA3.5) and 3 were opaque (OA2, OA3, and OA3.5). Specimens were prepared at a room temperature of 25°C or preheated to 60°C (n = 5 per shade at each temperature). The specimens were weighed 3 times: M1, dried for 24 hours at 37°C; M2, stored for 7 days in 75% ethanol at 37°C; and M3, dried for an additional 24 hours at 37°C. The weights were used to calculate the sorption and solubility of the composite resin and were analyzed using 2-way analysis of variance and Tukey tests (α = 5%). Composite resin specimens heated at 60°C yielded lower values of sorption and solubility than did specimens prepared at 25°C (P composite shades were found to be similar (P > 0.05), except for shade CA2, which presented a greater mean solubility value than OA2 (P = 0.004). Therefore, preheating was beneficial, as it lowered both the sorption and solubility of the evaluated composite resin, but opacity had little effect on these properties.

  13. Preheating in New Inflation

    CERN Document Server

    Desroche, M; Kratochvil, J; Linde, Andrei D; Desroche, Mariel; Felder, Gary N.; Kratochvil, Jan M.; Linde, Andrei

    2005-01-01

    During the last ten years a detailed investigation of preheating was performed for chaotic inflation and for hybrid inflation. However, nonperturbative effects during reheating in the new inflation scenario remained practically unexplored. We do a full analysis of preheating in new inflation, using a combination of analytical and numerical methods. We find that the decay of the homogeneous component of the inflaton field and the resulting process of spontaneous symmetry breaking in the simplest models of new inflation usually occurs almost instantly: for the new inflation on the GUT scale it takes only about 5 oscillations of the field distribution. The decay of the homogeneous inflaton field is so efficient because of a combined effect of tachyonic preheating and parametric resonance. At that stage, the homogeneous oscillating inflaton field decays into a collection of waves of the inflaton field, with a typical wavelength of the order of the inverse inflaton mass. This stage usually is followed by a long st...

  14. A simple method to prevent hard X-ray-induced preheating effects inside the cone tip in indirect-drive fast ignition implosions

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Dongxiao; Shan, Lianqiang; Zhou, Weimin; Wu, Yuchi; Zhu, Bin; Zhang, Feng; Bi, Bi; Zhang, Bo; Zhang, Zhimeng; Shui, Min; He, Yingling; Gu, Yuqiu, E-mail: yqgu@caep.cn; Zhang, Baohan [Science and Technology on Plasma Physics Laboratory, China Academy of Engineering Physics, Mianyang 621900 (China); Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); Peng, Xiaoshi; Xu, Tao; Wang, Feng; Yang, Zhiwen; Chen, Tao; Chen, Li; Chen, Ming [Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang 621900 (China); and others

    2016-06-15

    During fast-ignition implosions, preheating of inside the cone tip caused by hard X-rays can strongly affect the generation and transport of hot electrons in the cone. Although indirect-drive implosions have a higher implosion symmetry, they cause stronger preheating effects than direct-drive implosions. To control the preheating of the cone tip, we propose the use of indirect-drive fast-ignition targets with thicker tips. Experiments carried out at the ShenGuang-III prototype laser facility confirmed that thicker tips are effective for controlling preheating. Moreover, these results were consistent with those of 1D radiation hydrodynamic simulations.

  15. Effect of preheating on the film thickness of contemporary composite restorative materials

    Directory of Open Access Journals (Sweden)

    Dimitrios Dionysopoulos

    2014-12-01

    Conclusion: The film thickness of the composites tested is material dependent. The thickness of the preheated conventional composites is significantly lower than those at room temperature. The conventional composites provide film thickness values greater than those of the flowable composites regardless of preheating temperature.

  16. The effect of repeated preheating of dimethacrylate and silorane-based composite resins on marginal gap of class V restorations

    Directory of Open Access Journals (Sweden)

    Parnian Alizadeh Oskoee

    2017-03-01

    Full Text Available Background. One of the problems with composite resin restorations is gap formation at resin‒tooth interface. The present study evaluated the effect of preheating cycles of silorane- and dimethacrylate-based composite resins on gap formation at the gingival margins of Class V restorations. Methods. In this in vitro study, standard Class V cavities were prepared on the buccal surfaces of 48 bovine incisors. For restorative procedure, the samples were randomly divided into 2 groups based on the type of composite resin (group 1: di-methacrylate composite [Filtek Z250]; group 2: silorane composite [Filtek P90] and each group was randomly divided into 2 subgroups based on the composite temperature (A: room temperature; B: after 40 preheating cycles up to 55°C. Marginal gaps were measured using a stereomicroscope at ×40 and analyzed with two-way ANOVA. Inter- and intra-group comparisons were analyzed with post-hoc Tukey tests. Significance level was defined at P < 0.05. Results. The maximum and minimum gaps were detected in groups 1-A and 2-B, respectively. The effects of composite resin type, preheating and interactive effect of these variables on gap formation were significant (P<0.001. Post-hoc Tukey tests showed greater gap in dimethacrylate compared to silorane composite resins (P< 0.001. In each group, gap values were greater in composite resins at room temperature compared to composite resins after 40 preheating cycles (P<0.001. Conclusion. Gap formation at the gingival margins of Class V cavities decreased due to preheating of both composite re-sins. Preheating of silorane-based composites can result in the best marginal adaptation.

  17. Effects of Preheating and Storage Temperatures on Aroma Profile and Physical Properties of Citrus-Oil Emulsions.

    Science.gov (United States)

    Yang, Ying; Zhao, Chengying; Tian, Guifang; Lu, Chang; Zhao, Shaojie; Bao, Yuming; McClements, David Julian; Xiao, Hang; Zheng, Jinkai

    2017-09-06

    Citrus oils are used as good carrier oil for emulsion fabrication due to their special flavor and various health-promoting functions. In this study, the effects of preheating temperature (30, 40, 50, 60, and 70 °C) and storage temperature (4, 25, and 37 °C) on aroma profiles and physical properties of three citrus-oil (i.e., mandarin, sweet orange, and bergamot oils) emulsions were systematically investigated for the first time. The results demonstrated the significant impact of temperature on aroma profile and physical properties. The abundance of d-limonene was found to be the main factor determining the aroma of the three citrus-oil emulsions at different preheating and storage temperatures, while β-linalool and linalyl acetate were important for the aroma of bergamot oil emulsion. Preheating temperature showed a profound impact on the aroma of citrus-oil emulsions, and the aroma of different citrus oil emulsions showed different sensitivity to preheating temperature. Storage temperature was also able to alter the properties of citrus oil emulsions. The higher was the storage temperature, the more alteration of aroma and more instability of the emulsions there was, which could be attributed to the alteration of the oil components and the properties of emulsions. Among all three emulsions, bergamot-oil emulsion was the most stable and exhibited the most potent ability to preserve the aroma against high temperature. Our results would facilitate the application of citrus-oil emulsions in functional foods and beverages.

  18. Effects of extrusion-billet preheating on the microstructure and properties of Zr-2.5Nb pressure tube materials

    Energy Technology Data Exchange (ETDEWEB)

    Choubey, R.; Cann, C.D. [Atomic Energy of Canada Limited, Pinawa, Manitoba (Canada). Whiteshell Labs.; Aldridge, S.A. [Nu-Tech Precision Metals, Inc., Arnprior, Ontario (Canada); Theaker, J.R.; Coleman, C.E. [Atomic Energy of Canada Ltd., Chalk River, Ontario (Canada). Chalk River Labs.

    1996-12-31

    The effects of extrusion temperature and pre-heat soak time for billets on the mechanical properties of Zr-2.5Nb pressure tubes for CANDU reactors have been examined. The {beta}-quenched billets from a quadruple-melted ingot containing approximately 1,200 ppm of oxygen were extruded at 780, 815, and 850 C with pre-heat soak times of 15 to 300 min. The extruded hollows were finished by cold drawing (with a 28% reduction in area) and then stress relieving at 400 C. The {alpha}-phase grain structure, tensile strength, and fracture toughness properties were found to vary with the pre-heat temperature and soak time. All the materials were tough because embrittling impurities were absent. The tubes with 780 C preheat had a very fine and uniform {alpha}-grain structure, giving high strength and toughness at all soak times. The opposite was true for the 850 C soaks; the grain structure was coarse and inhomogeneous and the materials tended to be less strong and less touch. The tubes with the 815 C soaks showed intermediate values of strength and toughness. These variations in mechanical properties are discussed in terms of {alpha}-grain refinement and oxygen enrichment.

  19. Effect Of Preheating And Different Moisture Content Of Input Materials On Durability Of Pellets Made From Different Phytomass Content

    Directory of Open Access Journals (Sweden)

    Macák Miroslav

    2015-03-01

    Full Text Available This paper analyses the effects of the storage process on the durability of pellets made of different types of biomass (lucerne hay, maize stover, wheat straw, miscanthus, prickly lettuce for energy purposes. Pellets were produced on a hydraulic press that allowed modifying the size of pellets. The durability of pellets was measured on a special testing instrument according to the ASAE S269.4 (2007 standard method. The pellets used in the test were produced by pressing without preheating and with preheating. Durability rating was expressed as the ratio of the original mass of pellets and the mass of pellets remaining on a 17 mm opening sieve after tumbling. Storage negatively affected the durability of pellets made without preheating for all the types of biomass materials in different moisture contents. On the other hand, there was some positive response to storing of pellets made with preheating. The durability of pellets made of maize stover, wheat straw and miscanthus in the moisture content of 5 % increased with storing.

  20. Effect of Preheating on the Inertia Friction Welding of the Dissimilar Superalloys Mar-M247 and LSHR

    Science.gov (United States)

    Senkov, O. N.; Mahaffey, D. W.; Semiatin, S. L.

    2016-12-01

    Differences in the elevated temperature mechanical properties of cast Mar-M247 and forged LSHR make it difficult to produce sound joints of these alloys by inertia friction welding (IFW). While extensive plastic upset occurs on the LSHR side, only a small upset is typically developed on the Mar-M247 side. The limited plastic flow of Mar-M247 thus restricts the extent of "self-cleaning" and mechanical mixing of the mating surfaces, so that defects remain at the bond line after welding. In the present work, the effect of local preheating of Mar-M247 immediately prior to IFW on the welding behavior of Mar-M247/LSHR couples was determined. An increase in the preheat temperature enhanced the plastic flow of Mar-M247 during IFW, which resulted in extensive mechanical mixing with LSHR at the weld interface, the formation of extensive flash on both the Mar-M247 and LSHR sides, and a sound bond. Performed in parallel with the experimental work, finite-element-method (FEM) simulations showed that higher temperatures are achieved within the preheated sample during IFW relative to its non-preheated counterpart, and plastic flow is thus facilitated within it. Microstructure and post-weld mechanical properties of the welded samples were also established.

  1. Effect of substrate preheating temperature and coating thickness on residual stress in plasma sprayed hydroxyapatite coating

    Science.gov (United States)

    Tang, Dapei

    2015-07-01

    A thermal-mechanical coupling model was developed based on thermal-elastic- plastic theory according the special process of plasma spraying Hydroxyapatite (HA) coating upon Ti-6Al-4V substrate. On the one hand, the classical Fourier transient heat conduction equation was modified by introducing the effect item of deformation on temperature, on the other hand, the Johnson-Cook model, suitable for high temperature and high strain rate conditions, was used as constitutive equation after considering temperature softening effect, strain hardening effect and strain rate reinforcement effect. Based on the above coupling model, the residual stress field within the HA coating was simulated by using finite element method (FEM). Meanwhile, the substrate preheating temperature and coating thickness on the influence of residual stress components were calculated, respectively. The failure modes of coating were also preliminary analyzed. In addition, in order to verify the reliability of calculation, the material removal measurement technique was applied to determine the residual stress of HA coating near the interface. Some important conclusions are obtained.

  2. Effect of Intermediate Agents and Preheated Composites on Repair Bond Strength of Silorane-Based Composites

    Directory of Open Access Journals (Sweden)

    Fereshteh Shafiei

    2016-05-01

    Full Text Available Objectives: Repairing composite restorations is a challenging procedure especially when two different types of composites are used. This study aimed to compare the repair strength of silorane-based composite (SC (Filtek P90 with that of preheated SC, methacrylate composite (MC(Z250, flowable MC (Filtek Supreme Plus and different adhesive/composite combinations.Materials and Methods: Eighty-four SC specimens were fabricated and randomly divided into seven groups (G. In the control group (G7, SC was bonded immediately to SC. The other specimens were water-aged for two months and were then roughened, etched and repaired with the following materials: G1 Silorane Adhesive Bond (SAB/SC;G2 Preheated SC; G3 SAB/MC; G4 Adper Single Bond (SB/MC; G5 Flowable MC/MC; G6 Preheated MC. After water storage and thermocycling, the repaired specimens were subjected to shear bond strength testing. The data were analyzed using ANOVA and Tukey’s test.Results: Preheated SC and MC, flowable MC and SAB/SC resulted in bond strength comparable to that of the control group. Preheated SC showed significantly higher bond strength when compared to SAB/MC (P=0.04 and SB/MC (P<0.001. Bond strength of SB/MC was significantly lower than that of the other groups (P<0.05, except for SAB/SC and SAB/MC.Conclusion: All repairing materials except for SB/MC resulted in bond strength values comparable to that of the control group. Repair with preheated SC yielded the highest bond strength. 

  3. Effective temperatures of polymer laser ablation

    Science.gov (United States)

    Furzikov, Nickolay P.

    1991-09-01

    Effective temperatures of laser ablation of certain polymers are extracted from experimental dependences of ablation depths on laser fluences. Dependence of these temperatures on laser pulse durations is established. Comparison with the known thermodestruction data shows that the effective temperature corresponds to transient thermodestruction proceeding by the statistically most probable way.

  4. Preheating with Trilinear Interactions: Tachyonic Resonance

    CERN Document Server

    Dufaux, J F; Kofman, L; Peloso, M; Podolsky, D

    2006-01-01

    We investigate the effects of bosonic trilinear interactions in preheating after chaotic inflation. A trilinear interaction term allows for the complete decay of the massive inflaton particles, which is necessary for the transition to radiation domination. We found that typically the trilinear term is subdominant during early stages of preheating, but it actually amplifies parametric resonance driven by the four-legs interaction. In cases where the trilinear term does dominate during preheating, the process occurs through periodic tachyonic amplifications with resonance effects, which is so effective that preheating completes within a few inflaton oscillations. We develop an analytic theory of this process, which we call tachyonic resonance. We also study numerically the influence of trilinear interactions on the dynamics after preheating. The trilinear term eventually comes to dominate after preheating, leading to faster rescattering and thermalization than could occur without it. Finally, we investigate the...

  5. Effect of preheating of low shrinking resin composite on intrapulpal temperature and microtensile bond strength to dentin

    Science.gov (United States)

    El-Deeb, Heba A.; Abd El-Aziz, Sara; Mobarak, Enas H.

    2014-01-01

    The effect of preheating of the silorane-based resin composite on intrapulpal temperature (IPT) and dentin microtensile bond strength (μTBS) was evaluated. For the IPT, teeth (n = 15) were sectioned to obtain discs of 0.5 mm thickness (2 discs/tooth). The discs were divided into three groups (n = 10/group) according to the temperature of the Filtek LS™ silorane-based resin composite during its placement, either at room temperature (23 ± 1 °C) or preheated to 54 °C or 68 °C using a commercial Calset™ device. Discs were subjected to a simulated intrapulpal pressure (IPP) and placed inside a specially constructed incubator adjusted at 37 °C. IPT was measured before, during and after placement and curing of the resin composite using K-type thermocouple. For μTBS testing, flat occlusal middentin surfaces (n = 24) were obtained. P90 System Adhesive was applied according to manufacturer’s instructions then Filtek LS was placed at the tested temperatures (n = 6). Restorative procedures were done while the specimens were connected to IPP simulation. IPP was maintained and the specimens were immersed in artificial saliva at 37 °C for 24 h before testing. Each specimen was sectioned into sticks (0.9 ± 0.01 mm2). The sticks (24/group) were subjected to μTBS test and their modes of failure were determined using scanning electron microscope (SEM). For both preheated groups, IPT increased equally by 1.5–2 °C upon application of the composite. After light curing, IPT increased by 4–5 °C in all tested groups. Nevertheless, the IPT of the preheated groups required a longer time to return to the baseline temperature. One-way ANOVA revealed no significant difference between the μTBS values of all groups. SEM revealed predominately mixed mode of failure. Preheating of silorane-based resin composite increased the IPT but not to the critical level and had no effect on dentin μTBS. PMID:26257945

  6. Effect of preheating of low shrinking resin composite on intrapulpal temperature and microtensile bond strength to dent

    Directory of Open Access Journals (Sweden)

    Heba A. El-Deeb

    2015-05-01

    Full Text Available The effect of preheating of the silorane-based resin composite on intrapulpal temperature (IPT and dentin microtensile bond strength (μTBS was evaluated. For the IPT, teeth (n = 15 were sectioned to obtain discs of 0.5 mm thickness (2 discs/tooth. The discs were divided into three groups (n = 10/group according to the temperature of the Filtek LS™ silorane-based resin composite during its placement, either at room temperature (23 ± 1 °C or preheated to 54 °C or 68 °C using a commercial Calset™ device. Discs were subjected to a simulated intrapulpal pressure (IPP and placed inside a specially constructed incubator adjusted at 37 °C. IPT was measured before, during and after placement and curing of the resin composite using K-type thermocouple. For μTBS testing, flat occlusal middentin surfaces (n = 24 were obtained. P90 System Adhesive was applied according to manufacturer’s instructions then Filtek LS was placed at the tested temperatures (n = 6. Restorative procedures were done while the specimens were connected to IPP simulation. IPP was maintained and the specimens were immersed in artificial saliva at 37 °C for 24 h before testing. Each specimen was sectioned into sticks (0.9 ± 0.01 mm2. The sticks (24/group were subjected to μTBS test and their modes of failure were determined using scanning electron microscope (SEM. For both preheated groups, IPT increased equally by 1.5–2 °C upon application of the composite. After light curing, IPT increased by 4–5 °C in all tested groups. Nevertheless, the IPT of the preheated groups required a longer time to return to the baseline temperature. One-way ANOVA revealed no significant difference between the μTBS values of all groups. SEM revealed predominately mixed mode of failure. Preheating of silorane-based resin composite increased the IPT but not to the critical level and had no effect on dentin μTBS.

  7. Effect of preheating of low shrinking resin composite on intrapulpal temperature and microtensile bond strength to dentin.

    Science.gov (United States)

    El-Deeb, Heba A; Abd El-Aziz, Sara; Mobarak, Enas H

    2015-05-01

    The effect of preheating of the silorane-based resin composite on intrapulpal temperature (IPT) and dentin microtensile bond strength (μTBS) was evaluated. For the IPT, teeth (n = 15) were sectioned to obtain discs of 0.5 mm thickness (2 discs/tooth). The discs were divided into three groups (n = 10/group) according to the temperature of the Filtek LS™ silorane-based resin composite during its placement, either at room temperature (23 ± 1 °C) or preheated to 54 °C or 68 °C using a commercial Calset™ device. Discs were subjected to a simulated intrapulpal pressure (IPP) and placed inside a specially constructed incubator adjusted at 37 °C. IPT was measured before, during and after placement and curing of the resin composite using K-type thermocouple. For μTBS testing, flat occlusal middentin surfaces (n = 24) were obtained. P90 System Adhesive was applied according to manufacturer's instructions then Filtek LS was placed at the tested temperatures (n = 6). Restorative procedures were done while the specimens were connected to IPP simulation. IPP was maintained and the specimens were immersed in artificial saliva at 37 °C for 24 h before testing. Each specimen was sectioned into sticks (0.9 ± 0.01 mm(2)). The sticks (24/group) were subjected to μTBS test and their modes of failure were determined using scanning electron microscope (SEM). For both preheated groups, IPT increased equally by 1.5-2 °C upon application of the composite. After light curing, IPT increased by 4-5 °C in all tested groups. Nevertheless, the IPT of the preheated groups required a longer time to return to the baseline temperature. One-way ANOVA revealed no significant difference between the μTBS values of all groups. SEM revealed predominately mixed mode of failure. Preheating of silorane-based resin composite increased the IPT but not to the critical level and had no effect on dentin μTBS.

  8. Effect of Pre-heating on Microtensile Bond Strength of Composite Resin to Dentin.

    Directory of Open Access Journals (Sweden)

    Abdolrahim Davari

    2014-10-01

    Full Text Available Direct composite resin restorations are widely used and the impact of different storage temperatures on composites is not well understood. The purpose of this study was to evaluate the microtensile bond strength of composite to dentin after different pre-curing temperatures.Occlusal surfaces of 44 human molars were ground with diamond burs under water coolant and polished with 600 grit silicon carbide papers to obtain flat dentin surfaces. The dentin was etched with 37% phosphoric acid and bonded with Adper Single Bond 2 according to the manufacturer's instructions. The specimens were randomly divided into two groups (n=22 according to the composite resin applied: FiltekP60 and Filtek Z250. Each group included three subgroups of composite resin pre-curing temperatures (4°C, 23°C and 37°C. Composite resins were applied to the dentin surfaces in a plastic mold (8mm in diameter and 4mm in length incrementally and cured. Twenty-two composite-to-dentin hour-glass sticks with one mm(2 cross-sectional area per group were prepared. Microtensile bond strength measurements were made using a universal testing machine at a crosshead speed of one mm/min. For statistical analysis, t-test, one-way and two-way ANOVA were used. The level of significance was set at P<0.05.Filtek P60 pre-heated at 37ºC had significantly higher microtensile bond strength than Filtek Z250 under the same condition. The microtensile bond strengths were not significantly different at 4ºC, 23ºC and 37ºC subgroups of each composite resin group.Filtek P60 and Filtek Z250 did not have significantly different microtensile bond strengths at 4ºC and 23ºC but Filtek P60 had significantly higher microtensile bond strength at 37 ºC. Composite and temperature interactions had significant effects on the bond strength.

  9. Effect of diluted and preheated oxidizer on the emission of methane flameless combustion

    Science.gov (United States)

    Hosseini, Seyed Ehsan; Salehirad, Saber; Wahid, M. A.; Sies, Mohsin Mohd; Saat, Aminuddin

    2012-06-01

    In combustion process, reduction of emissions often accompanies with output efficiency reduction. It means, by using current combustion technique it is difficult to obtainlow pollution and high level of efficiency in the same time. In new combustion system, low NOxengines and burners are studied particularly. Recently flameless or Moderate and Intensive Low oxygen Dilution (MILD) combustion has received special attention in terms of low harmful emissions and low energy consumption. Behavior of combustion with highly preheated air was analyzed to study the change of combustion regime and the reason for the compatibility of high performance and low NOx production. Sustainability of combustion under low oxygen concentration was examined when; the combustion air temperature was above the self-ignition temperature of the fuel. This paper purposes to analyze the NOx emission quantity in conventional combustion and flameless combustion by Chemical Equilibrium with Applications (CEA) software.

  10. Effects of Preheating Temperature,Moisture and Sodium Metabisulfite Content on Property of Maize Flour Dough

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Processing temperature,maze flour particle size,and level of water and sodium metabisulfite were varied during the preparation of maize noodles.Preheated to 90-95 ℃ a mixture of maize flour or meal,water(43%-45% moisture) and salt enabled the preparation of noodles using a pasta extruder.Maize flour with smaller particle size yielded better noodles than did maize meal.The addition of sodium metabisulfite enabled the production of noodles at lower processing temperatures; however,cooking losses increased.Processing maize flour with higher water absorption yielded noodles that required longer cooking time but with decreased losses.The functionalities of starch and protein in raw ingredients and in products were determined.Starch gelatinized and retorgraded during processing maize noodles,as indicated by changes in pasting viscosity curves.Maize proteins contributed to the increased viscosity of dough above 40 ℃.The increased integrity of cooked maize noodles,however,corresponded to the increased amounts of gelatinized and retrograded starch.

  11. Effects of preheating of crude palm oil (CPO) on injection system, performance and emission of a diesel engine

    Energy Technology Data Exchange (ETDEWEB)

    Bari, S.; Lim, T.H.; Yu, C.W. [Universiti Sains Malaysia, School of Mechanical Engineering, Penang (Malaysia)

    2002-11-01

    Crude palm oil (CPO) is one of the vegetable oils that have potential for use as fuels for diesel engines. CPO is renewable, and is safe and easy to handle. However, at room temperature (30-32 deg C) CPO has a viscosity about 10 times higher than that of diesel. To lower CPO's viscosity to the level of diesel's viscosity, a heating temperature of at least 92 deg C is needed. At this temperature, there is a concern that the close-fitting parts of the injection system might be affected. This study focused on finding out the effects of preheating of fuel on the injection system utilising a modified method of friction test, which involves injecting fuel outside the combustion chamber during motoring. Results show that preheating of CPO lowered CPO's viscosity and provided smooth fuel flow, but did not affect the injection system, even heating up to 100 deg C. Nevertheless, heating up to such a high temperature offered no benefits in terms of engine performance. However, heating is necessary for smooth flow and to avoid fuel filter clogging. Both can be achieved by heating CPO to 60 deg C. Combustion analyses comparisons between CPO and diesel found that CPO produced a higher peak pressure of 6%, a shorter ignition delay of 2.6 deg, a lower maximum heat release rate and a longer combustion period. Over the entire load range, CPO combustion produced average CO and NO emissions that were 9.2 and 29.3% higher, respectively, compared with those from diesel combustion. (Author)

  12. Electrolytic Effects During Tissue Ablation by Electroporation.

    Science.gov (United States)

    Rubinsky, Liel; Guenther, Enric; Mikus, Paul; Stehling, Michael; Rubinsky, Boris

    2016-10-01

    Nonthermal irreversible electroporation is a new tissue ablation technique that consists of applying pulsed electric fields across cells to induce cell death by creating permanent defects in the cell membrane. Nonthermal irreversible electroporation is of interest because it allows treatment near sensitive tissue structures such as blood vessels and nerves. Two recent articles report that electrolytic reaction products at electrodes can be combined with electroporation pulses to augment and optimize tissue ablation. Those articles triggered a concern that the results of earlier studies on nonthermal irreversible electroporation may have been tainted by unaccounted for electrolytic effects. The goal of this study was to reexamine previous studies on nonthermal irreversible electroporation in the context of these articles. The study shows that the results from some of the earlier studies on nonthermal irreversible electroporation were affected by unaccounted for electrolysis, in particular the research with cells in cuvettes. It also shows that tissue ablation ascribed in the past to irreversible electroporation is actually caused by at least 3 different cytotoxic effects: irreversible electroporation without electrolysis, irreversible electroporation combined with electrolysis, and reversible electroporation combined with electrolysis. These different mechanisms may affect cell and tissue ablation in different ways, and the effects may depend on various clinical parameters such as the polarity of the electrodes, the charge delivered (voltage, number, and length of pulses), and the distance of the target tissue from the electrodes. Current clinical protocols employ ever-increasing numbers of electroporation pulses to values that are now an order of magnitude larger than those used in our first fundamental nonthermal irreversible electroporation studies in tissues. The different mechanisms of cell death, and the effect of the clinical parameters on the mechanisms may

  13. Restoring the sting to metric preheating

    CERN Document Server

    Bassett, B A; Maartens, R; Kaiser, D I; Bassett, Bruce A.; Gordon, Chris; Maartens, Roy; Kaiser, David I.

    2000-01-01

    The relative growth of field and metric perturbations during preheating is sensitive to initial conditions set in the preceding inflationary phase. Recent work suggests this may protect super-Hubble metric perturbations from resonant amplification during preheating. We show that this possibility is fragile and extremely sensitive to the specific form of the interactions between the inflaton and other fields. The suppression is naturally absent in two classes of preheating in which either (1) the critical points (hence the vacua) of the effective potential during inflation are deformed away from the origin, or (2) the effective masses of fields during inflation are small but during preheating are large. Unlike the simple toy model of a g^2 \\phi^2 \\chi^2 coupling, most realistic particle physics models contain these other features. Moreover, they generically lead to both adiabatic and isocurvature modes and non-Gaussian scars on super-Hubble scales. Large-scale coherent magnetic fields may also appear naturally...

  14. Recent Advances in Electrical Resistance Preheating of Aluminum Reduction Cells

    Science.gov (United States)

    Ali, Mohamed Mahmoud; Kvande, Halvor

    2017-02-01

    There are two mainpreheating methods that are used nowadays for aluminum reduction cells. One is based on electrical resistance preheating with a thin bed of small coke and/or graphite particles between the anodes and the cathode carbon blocks. The other is flame preheating, where two or more gas or oil burners are used. Electrical resistance preheating is the oldest method, but is still frequently used by different aluminum producers. Many improvements have been made to this method by different companies over the last decade. In this paper, important points pertaining to the preparation and preheating of these cells, as well as measurements made during the preheating process and evaluation of the performance of the preheating, are illustrated. The preheating times of these cells were found to be between 36 h and 96 h for cell currents between 176 kA and 406 kA, while the resistance bed thickness was between 13 mm and 60 mm. The average cathode surface temperature at the end of the preheating was usually between 800°C and 950°C. The effect of the preheating methods on cell life is unclear and no quantifiable conclusions can be drawn. Some works carried out in the mathematical modeling area are also discussed. It is concluded that there is a need for more studies with real situations for preheated cells on the basis of actual measurements. The expected development in electrical resistance preheating of aluminum reduction cells is also summarized.

  15. Dynamics of Symmetry Breaking and Tachyonic Preheating

    CERN Document Server

    Felder, G; Greene, P B; Kofman, L A; Linde, Andrei D; Tkachev, Igor I; Felder, Gary; Garcia-Bellido, Juan; Greene, Patrick B.; Kofman, Lev; Linde, Andrei; Tkachev, Igor

    2001-01-01

    We reconsider the old problem of the dynamics of spontaneous symmetry breaking using 3d lattice simulations, and develop a theory of tachyonic preheating, which occurs due to the spinodal instability of the scalar field. Tachyonic preheating is so efficient that symmetry breaking typically completes within a single oscillation of the field distribution as it rolls towards the minimum of its effective potential. As an application of this theory we consider preheating in the hybrid inflation scenario, including SUSY-motivated F-term and D-term inflationary models. We show that preheating in hybrid inflation is typically tachyonic and the stage of oscillations of a homogeneous component of the scalar fields driving inflation ends after a single oscillation. Our results may also be relevant for the theory of the formation of disoriented chiral condensates in heavy ion collisions.

  16. Preheating after Small-Field Inflation

    CERN Document Server

    Brax, Philippe; Mariadassou, Sophie

    2010-01-01

    Whereas preheating after chaotic and hybrid inflation models has been abundantly studied in the literature, preheating in small field inflation models, where the curvature of the inflaton potential is negative during inflation, remains less explored. In these models, a tachyonic instability at the end of inflation leads to a succession of exponentially large increases and \\emph{decreases} of the inflaton fluctuations as the inflaton condensate oscillates around the minimum of its potential. The net effect is a competition between low-momentum modes which grow and decrease significantly, and modes with higher momenta which grow less but also decrease less. We develop an analytical description of this process, which is analogous to the quantum mechanical problem of tunneling through a volcano-shaped potential. Depending on the parameters, preheating may be so efficient that it completes in less than one oscillation of the inflaton condensate. Preheating after small field inflation may also be followed by a long...

  17. Experimental measurement of ablation effects in plasma armature railguns

    Energy Technology Data Exchange (ETDEWEB)

    Parker, J.V.; Parsons, W.M.

    1986-01-01

    Experimental evidence supporting the importance of ablation in plasma armature railguns is presented. Experiments conducted using the HYVAX and MIDI-2 railguns are described. Several indirect effects of ablation are identified from the experimental results. An improved ablation model of plasma armature dynamics is proposed which incorporates the restrike process.

  18. EFFECT OF STORAGE, PRE-HEATING AND TURNING DURING HOLDING PERIOD ON THE HATCHABILITY OF BROILER BREEDER EGGS

    Directory of Open Access Journals (Sweden)

    A. MAHMUD AND T. N. PASHA1

    2008-07-01

    Full Text Available Two hundred forty fertile eggs of an average weight of 52-55g were taken from 32 weeks old broiler breeder flock. These eggs were divided into four groups i.e. A (Without turning and preheating, B (No turning but preheated, C (Turned but without preheating, and D (given both treatments preheating and turning with 60 eggs in each group. The eggs were stored with broad end upward at 16-20°C and 65-75% humidity. After storage for 5 days, the pre-heating of eggs of groups B and D was performed in an incubator where hot air at 30°C temperature was circulated for 6-7 hours to provide gradual warmth to the eggs before setting in the same incubator. The temperature of the incubator was maintained at 37.6°C with relative humidity of 70%. The eggs of groups C and D were turned on hourly basis at an angle of about 45° till 17 days of incubation. The hatchability values of eggs of groups A, B, C and D were 88.30 ± 0.30, 76.30 ± 0.30, 83.30 ± 0.30 and 79.90 ± 0.10%, respectively. Statistical analysis of the data by Chi-square test showed non-significant differences among treatments.

  19. Preheating after modular inflation

    Science.gov (United States)

    Barnaby, Neil; Bond, J. Richard; Huang, Zhiqi; Kofman, Lev

    2009-12-01

    We study (p)reheating in modular (closed string) inflationary scenarios, with a special emphasis on Kähler moduli/Roulette models. It is usually assumed that reheating in such models occurs through perturbative decays. However, we find that there are very strong non-perturbative preheating decay channels related to the particular shape of the inflaton potential (which is highly nonlinear and has a very steep minimum). Preheating after modular inflation, proceeding through a combination of tachyonic instability and broad-band parametric resonance, is perhaps the most violent example of preheating after inflation known in the literature. Further, we consider the subsequent transfer of energy to the standard model sector in scenarios where the standard model particles are confined to a D7-brane wrapping the inflationary blow-up cycle of the compactification manifold or, more interestingly, a non-inflationary blow-up cycle. We explicitly identify the decay channels of the inflaton in these two scenarios. We also consider the case where the inflationary cycle shrinks to the string scale at the end of inflation; here a field theoretical treatment of reheating is insufficient and one must turn instead to a stringy description. We estimate the decay rate of the inflaton and the reheat temperature for various scenarios.

  20. The effect of pre-heating silorane and methacrylate-based composites on microleakage of Class V restorations

    Directory of Open Access Journals (Sweden)

    Soley Arslan

    2012-01-01

    Full Text Available Objective: This study compared the effects of 4 different temperatures (4°C, 25°C, 37°C, 60°C on the microleakage of silorane and methacrylate-based composites in Class V cavities. Materials and Methods: Standard Class V cavities were prepared at the buccal and lingual surfaces of human molars. The specimens were randomly divided into 2 groups according to the composite resin used (Group I: Filtek Silorane Adhesive System and Filtek Silorane composite; Group II: Clearfil SE Bond and Aelite LS Posterior composite and into 4 subgroups according to temperature treatment (Group A: Refrigeration at 4°C; Group B (control: Storage at room temperature (25°C; Group C: Heated to 37°C and Group D: Heated to 60°C using Calset. Specimens were dyed with 0.5% basic fuchsin, sectioned, and evaluated at 25x magnification. Statistical analysis was performed using Mann-Whitney U and Kruskal-Wallis tests at P0.05. Differences in temperature did not significantly affect microleakage values for Filtek Silorane (P>0.05; however, microleakage values of Aelite LS Posterior composite varied according to temperature treatment, with heating resulted in significantly less microleakage than cooling (between Groups IID and IIA and Groups IIC and IIA (P<0.05. Conclusion: Pre-heating was shown to reduce microleakage values of Aelite LS Posterior composite, but did not significantly alter the microleakage values of Filtek Silorane composite.

  1. Pre-heating mitigates composite degradation

    Directory of Open Access Journals (Sweden)

    Jessika Calixto da SILVA

    2015-12-01

    Full Text Available ABSTRACT Dental composites cured at high temperatures show improved properties and higher degrees of conversion; however, there is no information available about the effect of pre-heating on material degradation. Objectives This study evaluated the effect of pre-heating on the degradation of composites, based on the analysis of radiopacity and silver penetration using scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS. Material and Methods Thirty specimens were fabricated using a metallic matrix (2x8 mm and the composites Durafill VS (Heraeus Kulzer, Z-250 (3M/ESPE, and Z-350 (3M/ESPE, cured at 25°C (no pre-heating or 60°C (pre-heating. Specimens were stored sequentially in the following solutions: 1 water for 7 days (60°C, plus 0.1 N sodium hydroxide (NaOH for 14 days (60°C; 2 50% silver nitrate (AgNO3 for 10 days (60°C. Specimens were radiographed at baseline and after each storage time, and the images were evaluated in gray scale. After the storage protocol, samples were analyzed using SEM/EDS to check the depth of silver penetration. Radiopacity and silver penetration data were analyzed using ANOVA and Tukey’s tests (α=5%. Results Radiopacity levels were as follows: Durafill VSZ-350>Z-250 (p<0.05. After storage in water/NaOH, pre-heated specimens presented higher radiopacity values than non-pre-heated specimens (p<0.05. There was a lower penetration of silver in pre-heated specimens (p<0.05. Conclusions Pre-heating at 60°C mitigated the degradation of composites based on analysis of radiopacity and silver penetration depth.

  2. Effect of pre-heated dual-cured resin cements on the bond strength of indirect restorations to dentin

    Directory of Open Access Journals (Sweden)

    Alexandre Morais

    2012-04-01

    Full Text Available This study evaluated the effects of resin luting agents (LA polymerized using increased temperature on the in vitro microtensile bond strength (mTBS of indirect restorations to dentin. The occlusal dentin surfaces of 40 human third molars were exposed and flattened. The teeth were assigned to 8 groups (n = 5 according to the LA temperature (25°C o r 50°C, curing mode (dual- or self-curing mode, and product (Excite DSC/Variolink II [VII] and XP Bond/Calibra [Cal]. The bonding agents were applied to the dentin surfaces according to manufacturers' instructions. For preheated groups, the LAs were heated to 50°C, subsequently mixed on a heated stirrer surface, and applied to the previously heated pre-polymerized resin discs (2 mm thickness, TPH-Spectrum. The discs were bonded to the dentin surfaces, and the LAs were either exposed to a curing light according to manufacturers' instructions or allowed to self-cure. Specimens were stored in relative humidity at 37°C for 7 days. Specimens were mesio-distally and bucco-lingually sectioned to obtain multiple bonded beams with a 1-mm² cross-sectional area for mTBS testing. Data (MPa were analyzed by 2-way ANOVA and Tukey's post hoc test (a = 5% for each product. Specimen failure patterns were analyzed using a scanning electron microscope. VII groups showed higher mTBS at 50°C than at 25°C regardless of curing mode (p = 0.05. Cal groups showed similar mTBS at 25°C and 50°C in all activation modes. The use of some dual-polymerizing LAs at 50°C may improve the mTBS of indirect restorations to dentin.

  3. Effects of laser ablation on cemented tungsten carbide surface quality

    Energy Technology Data Exchange (ETDEWEB)

    Tan, J.L.; Butler, D.L.; Sim, L.M.; Jarfors, A.E.W. [Singapore Institute of Manufacturing Technology, Singapore (Singapore)

    2010-11-15

    Although laser micromachining has been touted as being the most promising way to fabricate micro tools, there has been no proper evaluation of the effects of laser ablation on bulk material properties. The current work demonstrates the effects of laser ablation on the properties of a cemented tungsten carbide surface. Of particular interest is the resultant increase in compressive residual stresses in the ablated surface. From this study it is seen that there are no adverse effects from laser ablation of cemented tungsten carbide that would preclude its use for the fabrication of micro-tools but a finishing process may not be avoidable. (orig.)

  4. Effects of laser ablation on cemented tungsten carbide surface quality

    Science.gov (United States)

    Tan, J. L.; Butler, D. L.; Sim, L. M.; Jarfors, A. E. W.

    2010-11-01

    Although laser micromachining has been touted as being the most promising way to fabricate micro tools, there has been no proper evaluation of the effects of laser ablation on bulk material properties. The current work demonstrates the effects of laser ablation on the properties of a cemented tungsten carbide surface. Of particular interest is the resultant increase in compressive residual stresses in the ablated surface. From this study it is seen that there are no adverse effects from laser ablation of cemented tungsten carbide that would preclude its use for the fabrication of micro-tools but a finishing process may not be avoidable.

  5. Surface Characteristics of Machined NiTi Shape Memory Alloy: The Effects of Cryogenic Cooling and Preheating Conditions

    Science.gov (United States)

    Kaynak, Y.; Huang, B.; Karaca, H. E.; Jawahir, I. S.

    2017-07-01

    This experimental study focuses on the phase state and phase transformation response of the surface and subsurface of machined NiTi alloys. X-ray diffraction (XRD) analysis and differential scanning calorimeter techniques were utilized to measure the phase state and the transformation response of machined specimens, respectively. Specimens were machined under dry machining at ambient temperature, preheated conditions, and cryogenic cooling conditions at various cutting speeds. The findings from this research demonstrate that cryogenic machining substantially alters austenite finish temperature of martensitic NiTi alloy. Austenite finish ( A f) temperature shows more than 25 percent increase resulting from cryogenic machining compared with austenite finish temperature of as-received NiTi. Dry and preheated conditions do not substantially alter austenite finish temperature. XRD analysis shows that distinctive transformation from martensite to austenite occurs during machining process in all three conditions. Complete transformation from martensite to austenite is observed in dry cutting at all selected cutting speeds.

  6. Preheating with fractional powers

    Science.gov (United States)

    Moghaddam, Hossein Bazrafshan; Brandenberger, Robert

    2016-11-01

    We consider preheating in models in which the potential for the inflaton is given by a fractional power, as is the case in axion monodromy inflation. We assume a standard coupling between the inflaton field and a scalar matter field. We find that in spite of the fact that the oscillation of the inflaton about the field value which minimizes the potential is anharmonic, there is nevertheless a parametric resonance instability, and we determine the Floquet exponent which describes this instability as a function of the parameters of the inflaton potential.

  7. Effect of Preheating and Precooling on the Flexural Strength and Modulus of Elasticity of Nanohybrid and Silorane-based Composite

    Directory of Open Access Journals (Sweden)

    Farahnaz Sharafeddin

    2015-09-01

    Full Text Available Statement of the Problem: Composite resin may be used in different temperatures; it is crucial to determine the effect of temperature on mechanical properties of nanohybrid and silorane-based composite. Purpose: This in vitro study compared the flexural strength and modulus of elasticity of nanohybrid and silorane-based resin composite, at 4˚C, room temperature (25˚C, and 45˚C. Materials and Method: In this experimental study, 60 specimens were prepared in a metal split mold (2×2×25mm. Two different resin composites, Filtek Z250 XT (3M/ ESPE and Filtek P90 (3M/ESPE, were evaluated. The material were inserted into split molds at room temperature, 4˚C or 45˚C and cured with LED (1200 mW/cm2 for 20 seconds in four points (n=10. Then, a three-point bending test was performed using a universal testing machine at a crosshead speed of 0.5 mm/min for measuring the flexural strength and flexural modulus of samples. The data were analyzed by the two-way ANOVA and Tukey test (p< 0.05. Results: The mean highest flexural strength was observed at 45˚C, showing statistically significant difference with flexural strength at 4˚C (p= 0.0001 and 25˚C (p= 0.003 regardless of the type of resin composite. The flexural modulus at 45˚C was highest, showing the statistically significant difference with flexural modulus at 4˚C (p= 0.0001 and 25˚C (p= 0.002. The flexural modulus was statistically different between nanohybrid and silorane-based resin composite (p= 0.01 in 25˚C and 45˚C, but there were no statistically significant differences between flexural strength of Filtek Z250 XT and Filtek P90 regardless of the temperatures (p= 0.062. Conclusion: Preheating the resin composite at 45˚C improves flexural strength and modulus of nanohybrid and silorane-based resin composite. However, flexural strength and modulus of the tested materials were not affected by precooling. The flexural modulus of nanohybrid resin composite was significantly higher than

  8. The effects of late homogenization conditions on the Mg2Si particle size in a slow pre-heated 6063 aluminum extrusion billet

    Science.gov (United States)

    Kayıkcı, R.; Kocaman, E.; Şirin, S.; ćolak, M.

    2015-03-01

    In order to investigate the effect of late homogenization conditions on the Mg2Si precipitation of 6063 grade extrusion billets are slow pre-heated to intentionally have large Mg2Si particle precipitation. Then the billets are water quenched to preserve this microstructure for late homogenizations. Finally billets are re-heated using two different furnace temperature as 450°C and 500°C at which temperatures the billet are held for 0.5 h, 1 h, 1.5 h, 2 h and 2.5 h periods and water quenched before being taken to metallographic examinations.

  9. Effects of preheating and precooling on the hardness and shrinkage of a composite resin cured with QTH and LED.

    Science.gov (United States)

    Osternack, F H; Caldas, D B M; Almeida, J B; Souza, E M; Mazur, R F

    2013-01-01

    The aim of this study was to evaluate in vitro the hardness and shrinkage of a pre-cooled or preheated hybrid composite resin cured by a quartz-tungsten-halogen light (QTH) and light-emitting diode (LED) curing units. The temperature on the tip of the devices was also investigated. Specimens of Charisma resin composite were produced with a metal mold kept under 37°C. The syringes were submitted to 4°C, 23°C, and 60°C (n=20) before light-curing, which was carried out with the Optilux 501 VCL and Elipar FreeLight 2 units for 20 seconds. The specimens were kept under 37°C in a high humidity condition and darkness for 48 hours. The Knoop hardness test was carried out with a 50 gram-force (gf) load for 10 seconds, and the measurement of the shrinkage gap was carried out using an optical microscope. The data were subjected to analysis of variance and the Games-Howell test (α=0.05). The mean hardness of the groups were similar, irrespective of the temperatures (p>0.05). For 4°C and 60°C, the top surface light-cured by LED presented significantly reduced shrinkage when compared with the bottom and to both surfaces cured by QTH (phardness was not affected by pre-cooling or preheating. However, polymerization shrinkage was slightly affected by different pre-polymerization temperatures. The QTH-curing generated greater shrinkage than LED-curing only when the composite was preheated. Different temperatures did not affect the composite hardness and shrinkage when cured by a LED curing unit.

  10. Effects of target pre-heating and expansion on terahertz radiation production from intense laser-solid interactions

    Institute of Scientific and Technical Information of China (English)

    X.H.Yuan; Y.Fang; D.C.Carroll; D.A.MacLellan; F.Du; N.Booth; M.Burza; M.Chen; R.J.Gray; Y.F.Jin; Y.T.Li; Y.Liu; D.Neely; H.Powell; G.Scott; C.-G.Wahlstrm; J.Zhang; P.McKenna; Z.M.Sheng

    2014-01-01

    The first experimental measurements of intense(~7 × 1019 W cm-2) laser-driven terahertz(THz) radiation from a solid target which is preheated by an intense pulse of laser-accelerated protons is reported. The total energy of the THz radiation is found to decrease by approximately a factor of 2 compared to a cold target reference. This is attributed to an increase in the scale length of the preformed plasma, driven by proton heating, at the front surface of the target,where the THz radiation is generated. The results show the importance of controlling the preplasma scale length for THz production.

  11. Effect of preheating on the damage to tungsten targets after repetitive ITER ELM-like heat loads

    Energy Technology Data Exchange (ETDEWEB)

    Makhlay, V A [Institute of Plasma Physics of the NSC KIPT 1, Akademicheskaya, 61108 Kharkov (Ukraine); Bandura, A N [Institute of Plasma Physics of the NSC KIPT 1, Akademicheskaya, 61108 Kharkov (Ukraine); Byrka, O V [Institute of Plasma Physics of the NSC KIPT 1, Akademicheskaya, 61108 Kharkov (Ukraine); Garkusha, I E [Institute of Plasma Physics of the NSC KIPT 1, Akademicheskaya, 61108 Kharkov (Ukraine); Chebotarev, V V [Institute of Plasma Physics of the NSC KIPT 1, Akademicheskaya, 61108 Kharkov (Ukraine); Tereshin, V I [Institute of Plasma Physics of the NSC KIPT 1, Akademicheskaya, 61108 Kharkov (Ukraine); Landman, I [Forschungszentrum Karlsruhe, IHM, 76021 Karlsruhe (Germany)

    2007-03-15

    The behaviour of a preheated tungsten target under repetitive pulsed plasma impacts of the energy density 0.75 MJ m{sup -2} with the pulse duration of 0.25 ms was studied with the quasi-stationary plasma accelerator (QSPA) Kh-50. Two identical samples of pure sintered tungsten have been exposed to numbers of pulses exceeding 100. One sample was maintained at room temperature and the other sample preheated at 650 deg. C. The experiments demonstrated that on the cold surface some macro-cracks dominate, but on the hot surface they do not develop. However, in both cases some fine meshes of micro-cracks are observed. With increasing the number of exposures, the width of the micro-cracks gradually increases, achieving 0.8-1.5 {mu}m after 100 pulses. In addition, the SEM shows some cellular structure with the cell sizes about 0.3 {mu}m, and after large numbers of exposures some blisters of sizes up to 100-150 {mu}m appear.

  12. Effects of Confined Laser Ablation on Laser Plasma Propulsion

    Institute of Scientific and Technical Information of China (English)

    ZHENG Zhi-Yuan; ZHANG Jie; LU Xin; HAO Zuo-Qiang; XU Miao-Hua; WANG Zhao-Hua; WEI Zhi-Yi

    2005-01-01

    @@ We investigate the effects of confined laser ablation on laser plasma propulsion. Compared with planar ablation,the cavity ablation provides an effective way to obtain a large target momentum and a high coupling coefficient.When laser pukes are focused into a cavity with 1 mm diameter and 2mm depth, a high coupling coefficient is obtained. By using a glass layer to cover the cavity, the coupling coefficient is enhanced by 10 times. Meanwhile,it is found that with the increase of the target surface size, the target momentum presents a linear increase.

  13. Isotope Effects of Solid Hydrogenic Pellet Ablation in Fusion Plasma

    Institute of Scientific and Technical Information of China (English)

    PENGLilin; DENGBaiquan; YANJiancheng; WANGXiaoyu

    2003-01-01

    The isotope effects of ablation processes in fusion plasma for five combinations of solid isotopic hydrogenic pellets H2, HD, D2,DT, T2 have been first time studied. The resuits show that the modifications caused by isotope effects for pellet erosion speeds range from 1 for hydrogen pellet down to 0. 487 for tritium pellet and are not negligible in ablation rate calculations. These effects lead to deeper mass deposition and improved core fueling efficiency.

  14. Preheating after N-flation

    CERN Document Server

    Battefeld, Diana

    2008-01-01

    We study preheating in N-flation, assuming the Mar\\v{c}enko-Pastur mass distribution, equal energy initial conditions at the beginning of inflation and equal axion-matter couplings, where matter is taken to be a single, massless bosonic field. By numerical analysis we find that preheating via parametric resonance is suppressed, indicating that the old theory of perturbative preheating is applicable. While the tensor-to-scalar ratio, the non-Gaussianity parameters and the scalar spectral index computed for N-flation are similar to those in single field inflation (at least within an observationally viable parameter region), our results suggest that the physics of preheating can differ significantly from the single field case.

  15. Oncogenesis: An "Off-Target" Effect of Radiofrequency Ablation.

    Science.gov (United States)

    Rozenblum, Nir; Zeira, Evelyne; Scaiewicz, Viviana; Bulvik, Baruch; Gourevitch, Svetlana; Yotvat, Hagit; Galun, Eithan; Goldberg, S Nahum

    2015-08-01

    To compare hepatocellular carcinoma (HCC) development after radiofrequency (RF) ablation, partial surgical hepatectomy, and a sham operation and to inhibit HCC recurrence after RF ablation in a mouse model of spontaneously forming HCC in the setting of chronic inflammation (ie, the MDR2 knockout model). Animal experiments were performed according to an approved animal care committee protocol. The authors compared the survival of MDR2 knockout mice (an inflammation-induced HCC model) that underwent RF ablation, 35% partial hepatectomy (ie, left lobectomy), or a sham operation (controls) by using Kaplan-Meier survival curve analysis. Tumor load and tumor frequency in mice that underwent sham operation were further compared with those of mice treated with RF ablation at 1 month after therapy by using a two-tailed Student t test. Liver slices from mice treated with RF ablation were stained for α-smooth muscle actin and Ki-67 to establish the role of liver regeneration in the tumorigenic effect of RF ablation. Finally, tumor load and tumor incidence were evaluated in mice treated with a c-met inhibitor after RF ablation by using the Mann-Whitney U test. Ablation of 3.5% ± 0.02 of the MDR2 knockout mice liver induced increased tumor load (P = .007) and reduced survival (P = .03) in comparison to that of controls, with no significant difference to the 10-fold volume removal of partial hepatectomy. Seven days after RF treatment, the border zone of the coagulation zone was surrounded by α-smooth muscle actin-positive activated myofibroblasts. A significant elevation of hepatocyte proliferation was also seen 7 days after RF ablation in the distant liver (ablated lobe: P = .003; untreated lobe: P = .02). A c-met inhibitor significantly attenuated HCC development in MDR2 knockout mice treated with RF ablation (P = .001). Liver regeneration induced by RF ablation facilitates c-met/hepatocyte growth factor axis-dependent HCC tumor formation after treatment in the MDR2

  16. Investigation of optimal fluoroglass preheat

    CERN Document Server

    Baba, S; Toyoda, T; Wakamatsu, O; Machida, T

    2002-01-01

    The regular preheat condition of fluoroglass GD-301 (Chiyoda Technol Co., its size is 1.5 mm phi x 8.5 mm.) is temperature 70 deg C and time 30 minutes. When we measured dose 5.00 Gy at high energy X-ray processed with this condition, we observed build-up phenomenon according to elapsed days. So we investigated the optimal preheat temperature and time by measuring fluoroglass doses daily for several days. Fluoroglasses were irradiated 2.00 Gy of 10 MV X-ray at the reference depth using MEVATRON KD 2/50 PRIMUS (Toshiba Co.). First, we measured doses during 17 days after preheating them for 30 minutes, changing preheat temperatures from 50 deg C to 350 deg C at some intervals. Second, we measured doses during 9 days after preheating them at 70 deg C and at temperatures representing the maximum value and the most frequent value, changing preheat time from 5 minutes to 2 hours at some intervals. Doses increased up to around 115 deg C and decreased after that, and it seemed as if glasses were annealed at 350 deg C...

  17. Combination Effect of Dry-Ice Blasting and Substrate Preheating on Plasma-Sprayed CoNiCrAlY Splats

    Science.gov (United States)

    Dong, Shujuan; Song, Bo; Hansz, Bernard; Liao, Hanlin; Coddet, Christian

    2013-02-01

    CoNiCrAlY splats were plasma-sprayed on the stainless steel substrate which was pretreated by dry-ice blasting. Only impact marks were distinguished on the glycerol-polluted substrate, while halo donut splats formed on the pretreated substrate because of the cleaning effect of dry-ice blasting on this organic substance. The proportions of different splat types vary as a function of the treatment time of dry-ice blasting. The condensation phenomenon was also detected on the substrate surface accompanying the cleaning effect after the pretreatment of dry-ice blasting. In this study, dry-ice blasting was investigated to be coupled with substrate preheating to control the substrate temperature. It was found that a regular disk-like CoNiCrAlY splat can be obtained as the substrate temperature is higher than dew point temperature.

  18. The effect of asteroid topography on surface ablation deflection

    Science.gov (United States)

    McMahon, Jay W.; Scheeres, Daniel J.

    2017-02-01

    Ablation techniques for deflecting hazardous asteroids deposit energy into the asteroid's surface, causing an effective thrust on the asteroid as the ablating material leaves normal to the surface. Although it has long been recognized that surface topography plays an important role in determining the deflection capabilities, most studies to date have ignored this aspect of the model. This paper focuses on understanding the topography for real asteroid shapes, and how this topography can change the deflection performance of an ablation technique. The near Earth asteroids Golevka, Bennu, and Itokawa are used as the basis for this study, as all three have high-resolution shape models available. This paper shows that naive targeting of an ablation method without accounting for the surface topography can lower the deflection performance by up to 20% in the cases studied in terms of the amount of acceleration applied in the desired direction. If the ablation thrust level is assumed to be 100 N, as used elsewhere in the literature, this misapplication of thrust translates to tens of kilometers per year in decreased semimajor axis change. However, if the ablation method can freely target any visible point on the surface of the asteroid, almost all of this performance can be recovered.

  19. Heat effects of metals ablated with femtosecond laser pulses

    Science.gov (United States)

    Hirayama, Yoichi; Obara, Minoru

    2002-09-01

    Heat effects of metallic bulk crystals of Au, Ag, Cu, and Fe ablated with femtosecond Ti:sapphire laser pulses is experimentally studied. As a result of X-ray diffraction (XRD) measurements, the XRD peak signal of the area ablated with Ti:sapphire laser is much smaller than that of the crystalline metal sample. While the crystal form of the metal sample is crystalline before laser ablation, the crystal form in the ablated area is partially changed into the amorphous form. The residual pulse energy that did not contribute to the ablation process remains, which leads to the formation of thin layer of melted phase. The melted layer is abruptly cooled down not to be re-crystallized, but to transform into amorphous form. It is evident that the area ablated with femtosecond laser is changed into amorphous metals. This mechanism would be the same as the melt-quenching generally used as the fabrication method of amorphous metals. This experimental result is consistent with the theoretical result.

  20. Metric-torsion preheating: cosmic dynamo mechanism?

    CERN Document Server

    de Andrade, L C Garcia

    2014-01-01

    Earlier Bassett et al [Phys Rev D 63 (2001) 023506] investigated the amplification of large scale magnetic fields during preheating and inflation in several different models. They argued that in the presence of conductivity resonance effect is weakened. From a dynamo equation in spacetimes endowed with torsion recently derived by Garcia de Andrade [Phys Lett B 711: 143 (2012)] it is shown that a in a universe with pure torsion in Minkowski spacetime the cosmological magnetic field is enhanced by ohmic or non-conductivity effect, which shows that the metric-torsion effects is worth while of being studied. In this paper we investigated the metric-torsion preheating perturbation, which leads to the seed cosmological magnetic field in the universe with torsion is of the order of $B_{seed}\\sim{10^{-37}Gauss}$ which is several orders of magnitude weaker than the decoupling value obtained from pure metric preheating of $10^{-15}Gauss$. Despite of the weakness of the magnetic field this seed field may seed the galact...

  1. Pre-heating mitigates composite degradation.

    Science.gov (United States)

    Silva, Jessika Calixto da; Rogério Vieira, Reges; Rege, Inara Carneiro Costa; Cruz, Carlos Alberto dos Santos; Vaz, Luís Geraldo; Estrela, Carlos; Castro, Fabrício Luscino Alves de

    2015-01-01

    Dental composites cured at high temperatures show improved properties and higher degrees of conversion; however, there is no information available about the effect of pre-heating on material degradation. Objectives This study evaluated the effect of pre-heating on the degradation of composites, based on the analysis of radiopacity and silver penetration using scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS). Material and Methods Thirty specimens were fabricated using a metallic matrix (2x8 mm) and the composites Durafill VS (Heraeus Kulzer), Z-250 (3M/ESPE), and Z-350 (3M/ESPE), cured at 25°C (no pre-heating) or 60°C (pre-heating). Specimens were stored sequentially in the following solutions: 1) water for 7 days (60°C), plus 0.1 N sodium hydroxide (NaOH) for 14 days (60°C); 2) 50% silver nitrate (AgNO3) for 10 days (60°C). Specimens were radiographed at baseline and after each storage time, and the images were evaluated in gray scale. After the storage protocol, samples were analyzed using SEM/EDS to check the depth of silver penetration. Radiopacity and silver penetration data were analyzed using ANOVA and Tukey's tests (α=5%). Results Radiopacity levels were as follows: Durafill VSZ-350>Z-250 (pheated specimens presented higher radiopacity values than non-pre-heated specimens (pheated specimens (pheating at 60°C mitigated the degradation of composites based on analysis of radiopacity and silver penetration depth.

  2. Anisotropies in the gravitational wave background from preheating.

    Science.gov (United States)

    Bethke, Laura; Figueroa, Daniel G; Rajantie, Arttu

    2013-07-05

    We investigate the anisotropies in the gravitational wave (GW) background produced at preheating after inflation. Using lattice field theory simulations of a massless preheating model, we show that the GW amplitude depends sensitively on the value of the decay product field χ coupled to the inflaton φ, with the only requisite that χ is light during inflation. We find a strong anisotropy in the amplitude of the GW background on large angular scales, the details of which strongly depend on the reheating dynamics. We expect similar conclusions for a wide class of inflationary models with light scalar fields. If future direct detection GW experiments are capable of detecting the GW produced by preheating, they should also be able to detect this effect. This could eventually provide a powerful way to distinguish between different inflationary and preheating scenarios.

  3. Gravitational-wave mediated preheating

    Directory of Open Access Journals (Sweden)

    Stephon Alexander

    2015-04-01

    Full Text Available We propose a new preheating mechanism through the coupling of the gravitational field to both the inflaton and matter fields, without direct inflaton–matter couplings. The inflaton transfers power to the matter fields through interactions with gravitational waves, which are exponentially enhanced due to an inflation–graviton coupling. One such coupling is the product of the inflaton to the Pontryagin density, as in dynamical Chern–Simons gravity. The energy scales involved are constrained by requiring that preheating happens fast during matter domination.

  4. Violent Preheating in Inflation with Nonminimal Coupling

    CERN Document Server

    Ema, Yohei; Mukaida, Kyohei; Nakayama, Kazunori

    2016-01-01

    We study particle production at the preheating era in inflation models with nonminimal coupling $\\xi \\phi^2R$ and quartic potential $\\lambda \\phi^4/4$ for several cases: real scalar inflaton, complex scalar inflaton and Abelian Higgs inflaton. We point out that the preheating proceeds much more violently than previously thought. If the inflaton is a complex scalar, the phase degree of freedom is violently produced at the first stage of preheating. If the inflaton is a Higgs field, the longitudinal gauge boson production is similarly violent. This is caused by a spike-like feature in the time dependence of the inflaton field, which may be understood as a consequence of short time scale during which the effective potential or kinetic term changes suddenly. The produced particles typically have very high momenta $k \\lesssim \\sqrt{\\lambda}M_\\text{P}$. The production might be so strong that almost all the energy of the inflaton is carried away within one oscillation for $\\xi^2\\lambda \\gtrsim 1$. This may significa...

  5. Cost effectiveness of day stay versus inpatient radiofrequency (RF) ablation for the treatment of supraventricular tachyarrhythmias

    Energy Technology Data Exchange (ETDEWEB)

    Weerasooriya, H.R. [Royal Perth Hospital, WA (Australia); Harris, A.H. [Monash Univ., Clayton, VIC (Australia); Davis, M.J.E. [Western Australia Univ., Nedlands, WA (Australia)

    1996-04-01

    It is well established that radiofrequency (RF) ablation is the most cost effective treatment strategy for patients with supraventricular tachycardia. Previous cost estimates assumed at least an overnight stay following RF ablation. Day stay RF ablation however appears to be a safe alternative. The aim of this study was to compare day stay and inpatient catheter ablation in terms of cost, efficacy and safety. This was a retrospective cost effectiveness analysis. The study population consisted of 25 consecutive patients who underwent impatient RF ablation (historical controls). Economic analysis was based upon a detailed clinical costing. The mean overall cost per patient of inpatient RF ablation in 1994 Australian dollar values is $2354 (SD, $642) compared with $1876 (SD, $595) for day stay RF ablation (p<0.01). Day stay RF ablation is a cost effective alternative to inpatient RF ablation. 16 refs., 2 tabs.

  6. Nonlinear Inflaton Fragmentation after Preheating

    CERN Document Server

    Felder, G N; Felder, Gary N.; Kofman, Lev

    2007-01-01

    We consider the nonlinear dynamics of inflaton fragmentation during and after preheating in the simplest model of chaotic inflation. While the earlier regime of parametric resonant particle production and the later turbulent regime of interacting fields evolving towards equilibrium are well identified and understood, the short intermediate stage of violent nonlinear dynamics remains less explored. Lattice simulations of fully nonlinear preheating dynamics show specific features of this intermediate stage: occupation numbers of the scalar particles are peaked, scalar fields become significantly non-gaussian and the field dynamics become chaotic and irreversible. Visualization of the field dynamics in configuration space reveals that nonlinear interactions generate non-gaussian inflaton inhomogeneities with very fast growing amplitudes. The peaks of the inflaton inhomogeneities coincide with the peaks of the scalar field(s) produced by parametric resonance. When the inflaton peaks reach their maxima, they stop ...

  7. Direct Measurements of Hot-Electron Preheat in Inertial Confinement Fusion

    Science.gov (United States)

    Christopherson, A. R.; Betti, R.; Howard, J.; Bose, A.; Forrest, C. J.; Theobald, W.; Campbell, E. M.; Delettrez, J. A.; Stoeckl, C.; Edgell, D. H.; Seka, W.; Davis, A. K.; Michel, D. T.; Glebov, V. Yu.; Wei, M. S.

    2016-10-01

    In laser-driven inertial confinement fusion, a spherical capsule of cryogenic DT with a low- Z (CH, Be) ablator is accelerated inward on low entropy to achieve high hot-spot pressures at stagnation with minimal driver energy. Hot electrons generated from laser-plasma instabilities can compromise this performance by preheating the DT fuel, which results in early decompression of the imploding shell and lower hot-spot pressures. The hot-electron energy deposited into the DT for direct-drive implosions is routinely inferred by subtracting hard x-ray signals between a cryogenic implosion and its mass-equivalent, all-CH implosion. However, this technique does not measure the energy deposited into the unablated DT, which fundamentally determines the final degradation in hot-spot pressure. In this work, we report on experiments conducted with high- Z payloads of varying thicknesses to determine the hot-electron energy deposited into a payload that is mass equivalent to the amount of unablated DT present in typical DT layered implosions on OMEGA. These are the first measurements to directly probe the effect of preheat on performance degradation. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  8. Clinical applications of preheated hybrid resin composite.

    Science.gov (United States)

    Rickman, L J; Padipatvuthikul, P; Chee, B

    2011-07-22

    This clinical article describes and discusses the use of preheated nanohybrid resin composite for the placement of direct restorations and luting of porcelain laminate veneers. Two clinical cases are presented. Preheating hybrid composite decreases its viscosity and film thickness offering the clinician improved handling. Preheating also facilitates the use of nanohybrid composite as a veneer luting material with relatively low polymerisation shrinkage and coefficient of thermal expansion compared to currently available resin luting cements.

  9. Reheating and preheating in the simplest extension of Starobinsky inflation

    CERN Document Server

    van de Bruck, C; Paduraru, L E

    2016-01-01

    The epochs of reheating and preheating are studied in a simple extension of the Starobinsky inflationary model, which consists of an $R^2$--correction to the Einstein--Hilbert action and an additional scalar field. We find that if the $R^2$--correction at the end of inflation is dynamically important, it affects the expansion rate and as a consequence the reheating and preheating processes. While we find that the reheating temperature and duration of reheating are only slightly affected, the effect has to be taken into account when comparing the theory to data. In the case of preheating, the gravitational corrections can significantly affect the decay of the second field. Particle production is strongly affected for certain values of the parameters in the theory.

  10. Investigation of Preheat Temprature Effect on the Sturcture of Functionally Graded Ni3Al/NiAl/NiTi Intermetallic Compound

    Directory of Open Access Journals (Sweden)

    Musa Kılıç

    2015-12-01

    Full Text Available In this study, a functional graded material (FGM consisted of NiTi NiAl and Ni3Al were manufactured by self-propagating high-temperature synthesis (SHS technique. These three different compound powders were mixed in a rotating container after accurately weighed and cold compacted under 200 MPa pressure. These pressed samples were produced for 200, 300 and 400 ° C preheating temperature by igniting with high voltage under argon gas atmosphere. The microstructures of these functional graded materials were examined by microscopy, Scanning Electron Microscopy (SEM and X-Ray Diffraction (XRD. Consequently, functional graded material successful generated by SHS in every three preheating temperature and the metallic desired compounds were obtained but, it was seen that apart from the main phases in the intersection there are other phases with more melting and gaps.

  11. Effects of caudolateral neostriatal ablations on pain-related behaviour in the chicken.

    Science.gov (United States)

    Gentle, M J; Hunter, L N; Corr, S A

    1997-04-01

    As a measure of pain-related behaviour, beak guarding was investigated by recording the pecking response of adult chickens to a visually attractive stimulus before and after bilateral suction ablation of the caudolateral neostriatum (CLN). Two control groups of birds were used: a sham-operated group and an ablated group, in which the ablation was confined to the rostral dorsolateral telencephalon. Comparing the birds that had undergone ablation with the sham-operated controls showed that the ablation did not affect pecking behaviour. Five days after ablation, all birds were subjected to partial amputation of one third of the beak. A significant reduction in pecking behaviour (beak-guarding) was observed in both control groups, but was not observed in those birds that had previously received CLN ablations. In a second experiment, where beak amputation preceeded CLN ablation by 6 days, ablation did not affect the reduced pecking. The absence of guarding or other pain-related behaviours would indicate that an intact CLN was necessary for these behaviours to develop but, once they had developed, ablation had no effect.

  12. Radiofrequency Ablation: Inflammatory Changes in the Periablative Zone Can Induce Global Organ Effects, including Liver Regeneration.

    Science.gov (United States)

    Rozenblum, Nir; Zeira, Evelyne; Bulvik, Baruch; Gourevitch, Svetlana; Yotvat, Hagit; Galun, Eithan; Goldberg, S Nahum

    2015-08-01

    To determine the kinetics of innate immune and hepatic response to the coagulation necrosis area that remains in situ after radiofrequency (RF) ablation, the cytokine profile of this response, and its local and global effect on the whole organ in a small-animal model. A standardized RF ablation dose (70°C for 5 minutes) was used to ablate more than 7% of the liver in 91 C57BL6 mice (wild type) according to a protocol approved by the animal care committee. The dynamic cellular response in the border zone surrounding ablation-induced coagulation and in the ablated lobe and an untreated lobe were characterized with immunohistochemistry 24 hours, 72 hours, 7 days, and 14 days after ablation (the time points at which cells migrate to necrotic tissues). After characterization of the cellular populations that reacted to the RF treatment, cytokines secreted by these cells were blocked, either by using interleukin-6 knockout mice (n = 24) or c-met inhibitor PHA 665752 (n = 15), to elucidate the key factors facilitating the wound healing response to RF ablation. Statistical significance was assessed with nonparametric analysis of variance. RF ablation induces a strong time-dependent immunologic response at the perimeter of the necrotic zone. This includes massive accumulation of neutrophils, activated myofibroblasts, and macrophages peaking at 24 hours, 7 days, and 14 days after ablation, respectively. In correlation with myofibroblast accumulation, RF ablation induced hepatocyte proliferation in both the ablated lobe and an untreated lobe (mean, 165.15 and 230.4 cyclin-dependent kinase 47-positive cells per ×20 field, respectively, at day 7; P RF ablation induces not only a local periablational inflammatory zone but also more global proliferative effects on the liver. These IL-6- and/or c-met-mediated changes could potentially account for some of the local and distant tumor recurrence observed after treatment. © RSNA, 2015 Online supplemental material is available for

  13. Fuel preheater for diesel engines

    Energy Technology Data Exchange (ETDEWEB)

    Crossett, J.J.; Crossett, M.C.

    1987-10-13

    A unit for preheating fuel for diesel engines is described having an engine coolant system and a lubrication system utilizing a flowable lubricant. The unit comprises a housing providing a fluid-tight enclosure, a heat exchange coil positioned in and spaced above the bottom of the enclosure and having loops providing a continuous path for the flow of the fuel to be heated. The heat exchange coil has at least one foot of length for each 25 cubic inches of volume of the enclosure and a diesel fuel outlet in the housing connected to one end of the heat exchange coil, a diesel fuel outlet in the housing and connected to the other end of the heat exchange coil, an inlet in the housing for connection of the interior of the enclosure surrounding the coil to a source of a hot heat exchange medium in a diesel engine so as to provide a source of heat for heating the heat exchange coil. An outlet near the top of the housing provides for return of the heat exchange medium to a diesel engine, and spray tube means extend horizontally from the inlet for the heat exchange medium and along the bottom of the housing beneath substantially the entire length of the heat exchange coil. The means have upwardly directed openings to provide for discharge of the heat exchange medium toward the coil and agitation of the heat exchange medium in the enclosure around and over the heat exchange coil.

  14. Characterization of preheated and non-preheated HY-80 steel weldments by transmission electron microscopy

    OpenAIRE

    Clark, David Richard

    1983-01-01

    Approved for public release; distribution in unlimited. Preheating HY-80 steel weldments is standard procedure, but it is an expensive and time consuming step in the fabrication of hull structures. The microstructures and hardness profiles of both a preheated (250 F--121 C) and a non-preheated (32 F--0 C) HY-80 steel weldment were studied to provide information and allow comparisons of the microstructural transformations that occur in the heat affected zone during shielded metal arc weldin...

  15. Effect of air-flow on the evaluation of refractive surgery ablation patterns.

    Science.gov (United States)

    Dorronsoro, Carlos; Schumacher, Silvia; Pérez-Merino, Pablo; Siegel, Jan; Mrochen, Michael; Marcos, Susana

    2011-02-28

    An Allegretto Eye-Q laser platform (Wavelight GmbH, Erlangen, Germany) was used to study the effect of air-flow speed on the ablation of artificial polymer corneas used for testing refractive surgery patterns. Flat samples of two materials (PMMA and Filofocon A) were ablated at four different air flow conditions. The shape and profile of the ablated surfaces were measured with a precise non-contact optical surface profilometer. Significant asymmetries in the measured profiles were found when the ablation was performed with the clinical air aspiration system, and also without air flow. Increasing air-flow produced deeper ablations, improved symmetry, and increased the repeatability of the ablation pattern. Shielding of the laser pulse by the plume of smoke during the ablation of plastic samples reduced the central ablation depth by more than 40% with no-air flow, 30% with clinical air aspiration, and 5% with 1.15 m/s air flow. A simple model based on non-inertial dragging of the particles by air flow predicts no central shielding with 2.3 m/s air flow, and accurately predicts (within 2 μm) the decrease of central ablation depth by shielding. The shielding effects for PMMA and Filofocon A were similar despite the differences in the ablation properties of the materials and the different full-shielding transmission coefficient, which is related to the number of particles ejected and their associated optical behavior. Air flow is a key factor in the evaluation of ablation patterns in refractive surgery using plastic models, as significant shielding effects are found with typical air-flow levels used under clinical conditions. Shielding effects can be avoided by tuning the air flow to the laser repetition rate.

  16. Explore the Energy-saving Effect of Decomposition Kiln System with Four-stage, Five-stage and Six-stage Preheater%四级、五级和六级预热预分解窑系统节能效果的探讨

    Institute of Scientific and Technical Information of China (English)

    李红建; 王国鸿; 周刘成; 李昌勇

    2013-01-01

    通过四级、五级和六级预热预分解窑系统节约煤电的比较,阐明了带余热发电的五级预热预分解窑系统的能源利用率高于带余热发电的四级预热预分解窑系统,而六级预热器系统比五级、四级预热器系统节能效果更好.采用六级预热器系统可以适当降低预热器出口废气温度,实现废气热焓的充分回收,从而有效地实现烧成系统的节能减排.%By contrasting energy-saving of decomposition kiln system with four-stage, five-stage and six-stage preheater, it clarified that energy efficiency of system with five-stage preheater and waste heat power generation was higher than system with four-stage preheater. The energy-saving effect of six-stage preheater is better than five-stage and four-stage preheater. Six-stage preheater system was appropriate to reduce the outlet exhaust gas temperature of the preheater, while the exhaust gas enthalpy could be fully recycled,which easily achieved the purpose of the energy-saving and emissions reduction of the firing system.

  17. Hard x-ray (>100 keV) imager to measure hot electron preheat for indirectly driven capsule implosions on the NIF.

    Science.gov (United States)

    Döppner, T; Dewald, E L; Divol, L; Thomas, C A; Burns, S; Celliers, P M; Izumi, N; Kline, J L; LaCaille, G; McNaney, J M; Prasad, R R; Robey, H F; Glenzer, S H; Landen, O L

    2012-10-01

    We have fielded a hard x-ray (>100 keV) imager with high aspect ratio pinholes to measure the spatially resolved bremsstrahlung emission from energetic electrons slowing in a plastic ablator shell during indirectly driven implosions at the National Ignition Facility. These electrons are generated in laser plasma interactions and are a source of preheat to the deuterium-tritium fuel. First measurements show that hot electron preheat does not limit obtaining the fuel areal densities required for ignition and burn.

  18. A Model Independent Approach to (p)Reheating

    CERN Document Server

    Özsoy, Ogan; Sinha, Kuver; Watson, Scott

    2015-01-01

    In this note we propose a model independent framework for inflationary (p)reheating. Our approach is analogous to the Effective Field Theory of Inflation, however here the inflaton oscillations provide an additional source of (discrete) symmetry breaking. Using the Goldstone field that non-linearly realizes time diffeormorphism invariance we construct a model independent action for both the inflaton and reheating sectors. Utilizing the hierarchy of scales present during the reheating process we are able to recover known results in the literature in a simpler fashion, including the presence of oscillations in the primordial power spectrum. We also construct a class of models where the shift symmetry of the inflaton is preserved during reheating, which helps alleviate past criticisms of (p)reheating in models of Natural Inflation. Extensions of our framework suggest the possibility of analytically investigating non-linear effects (such as rescattering and back-reaction) during thermalization without resorting t...

  19. Investigation on preheating process in SLS machine

    Institute of Scientific and Technical Information of China (English)

    李湘生; 史玉升; 莫健华; 黄树槐

    2001-01-01

    Selective laser sintering (SLS) is an important Rapid Prototyping method because its wide range of materials. The powder is fused and processed into a part because it is heated in the process. Preheating of powder on the surface of powder bed is a one important process which is a guarantee by which parts can be successfully fabricated and influences accuracy of parts fabricated in SLS technology. The uniformity of temperature on powder bed influences accuracy and performance of parts. It is necessary to understand the influences of the parameters of preheating set on uniformity of temperature on surface of powder bed. This paper analyzes general preheating process of irradiator for the preheating of powder on the surface of powder bed during SLS processing,and investigates influences of the flux density on the temperature field on the top surface of powder bed. The models of distribution of flux density and the distribution of surface temperature of powder bed are presented.The result predicted according to the models is reasonably consistent with experimental result. This model plays important role in design of preheating set and control of SLS processing. It is concluded that the uniformity of temperature field on the powder bed is determined mostly by the geometry of heating component and its fix location and the flux density is inverse proportional to the highness.

  20. Effect of ablation of complex fractionated atrial electrogram on vagal modulation in dogs

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shu-long; YANG Yan-zong; DONG Ying-xue; JIANG Peng; GAO Lian-jun; CHA Yong-mei; Douglas L.Packer; XIA Yun-long; YIN Xiao-meng; CHANG Dong

    2010-01-01

    Background Clinical observations have shown that the complex fractionated atrial electrogram (CFAE) associates with ganglionated plexus activity in the cardiac autonomic nervous system. This study aimed to investigate the impact of CFAE ablation on vagal modulation to atria and vulnerability to develop atrial fibrillation (AF).Methods Ten adult mongrel dogs were involved. Cervical sympathovagal trunks were decentralized and sympathetic effects were blocked. CFAE was color tagged on the atrial 3-dimensional image and ablated during AF induced by S1S2 programmed stimulation plus sympathovagal trunk stimulation. Atrial effective refractory period (ERP) and vulnerability window (VW) of AF were measured on baseline and at vagal stimulation at 4 atrium sites. Serial tissue sections from ablative and control specimens received hematoxylin and eosin staining for microscopic examination.Results Most CFAE areas were localized at the right superior pulmonary quadrant, distal coronary sinus (CSd)quadrant, and proximal coronary sinus (CSp) quadrant (21.74%, separately). Sinus rhythm cycle length (SCL) shortening did not decrease significantly after ablation at the sites, including right atrial appendage, left atrial appendage, CSd, and CSp (P >0.05). ERP shortening during vagal stimulation significantly decreased after ablation (P <0.01); the VW to vagal stimulation significantly decreased after ablation (P <0.05). The architecture of individual ganglia altered after ablation.Conclusions CFAE has an autonomic basis in dogs. The decreased SCL and ERP shortening to vagal stimulation after CFAE ablation demonstrate that CFAE ablation attenuates vagal modulation to the atria, thereby suppressing AF mediated by enhanced vagal activity. CFAE ablation could suppress AF mediated by enhanced vagal activity.

  1. Antibacterial effect of bismuth subsalicylate nanoparticles synthesized by laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Flores-Castañeda, Mariela [Instituto Nacional de Investigaciones Nucleares (Mexico); Vega-Jiménez, Alejandro L., E-mail: argelia.almaguer@mac.com; Almaguer-Flores, Argelia [Universidad Nacional Autónoma de México, Facultad de Odontología, DEPeI, I (Mexico); Camps, Enrique; Pérez, Mario [Instituto Nacional de Investigaciones Nucleares (Mexico); Silva-Bermudez, Phaedra [Instituto Nacional de Rehabilitación, Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa (Mexico); Berea, Edgardo [FarmaQuimia SA de CV. (Mexico); Rodil, Sandra E. [Universidad Nacional Autónoma de México, Instituto de Investigaciones en Materiales (Mexico)

    2015-11-15

    The antimicrobial properties of bismuth subsalicylate (BSS) nanoparticles against four opportunistic pathogens; E. coli, P. aeruginosa, S. aureus, and S. epidermidis were determined. BSS nanoparticles were synthesized by pulse laser ablation of a solid target in distilled water under different conditions. The nanoparticles were characterized using high-resolution transmission electron microscopy and absorption spectra and small angle X-ray scattering. The analysis shows that the colloids maintained the BSS structure and presented average particle size between 20 and 60 nm, while the concentration ranges from 95 to 195 mg/L. The antibacterial effect was reported as the inhibition ratio of the bacterial growth after 24 h and the cell viability was measured using the XTT assay. The results showed that the inhibition ratio of E. coli and S. epidermidis was dependant on the NPs size and/or concentration, meanwhile P. aeruginosa and S. aureus were more sensitive to the BSS nanoparticles independently of both the size and the concentration. In general, the BSS colloids with average particle size of 20 nm were the most effective, attaining inhibition ratios >80 %, similar or larger than those obtained with the antibiotic used as control. The results suggest that the BSS colloids could be used as effective antibacterial agents with potential applications in the medical area.

  2. The Development of Equilibrium After Preheating

    CERN Document Server

    Kofman, L A

    2001-01-01

    We present a fully nonlinear study of the development of equilibrium after preheating. Preheating is the exponentially rapid transfer of energy from the nearly homogeneous inflaton field to fluctuations of other fields and/or the inflaton itself. This rapid transfer leaves these fields in a highly nonthermal state with energy concentrated in infrared modes. We have performed lattice simulations of the evolution of interacting scalar fields during and after preheating for a variety of inflationary models. We have formulated a set of generic rules that govern the thermalization process in all of these models. Notably, we see that once one of the fields is amplified through parametric resonance or other mechanisms it rapidly excites other coupled fields to exponentially large occupation numbers. These fields quickly acquire nearly thermal spectra in the infrared, which gradually propagates into higher momenta. Prior to the formation of total equilibrium, the excited fields group into subsets with almost identica...

  3. Effect of oblique force source induced by laser ablation on ultrasonic generation.

    Science.gov (United States)

    Guo, Yuning; Yang, Dexing; Chang, Ying; Gao, Wei

    2014-01-13

    The effect of asymmetry caused by oblique line-shaped laser ablation on the generation of ultrasonic waves in metal, especially the effect of transverse component of the ablation force source on the ultrasonic waves is analyzed. Due to the oblique force source, the displacements of shear wave increase obviously by the enhanced shear force, the energy concentration area of longitudinal wave deflects to the small range centered on the incident direction while that of shear wave is approximately perpendicular to incident direction. In addition, surface wave enhances in the direction of transverse power flow. Furthermore, some ultrasonic characteristics under vortex laser ablation condition are inferred.

  4. Experimental Investigation of Flow Resistance in a Coal Mine Ventilation Air Methane Preheated Catalytic Oxidation Reactor

    Directory of Open Access Journals (Sweden)

    Bin Zheng

    2015-01-01

    Full Text Available This paper reports the results of experimental investigation of flow resistance in a coal mine ventilation air methane preheated catalytic oxidation reactor. The experimental system was installed at the Energy Research Institute of Shandong University of Technology. The system has been used to investigate the effects of flow rate (200 Nm3/h to 1000 Nm3/h and catalytic oxidation bed average temperature (20°C to 560°C within the preheated catalytic oxidation reactor. The pressure drop and resistance proportion of catalytic oxidation bed, the heat exchanger preheating section, and the heat exchanger flue gas section were measured. In addition, based on a large number of experimental data, the empirical equations of flow resistance are obtained by the least square method. It can also be used in deriving much needed data for preheated catalytic oxidation designs when employed in industry.

  5. Gauge-preheating and the end of axion inflation

    CERN Document Server

    Adshead, Peter; Scully, Timothy R; Sfakianakis, Evangelos I

    2015-01-01

    We study the onset of the reheating epoch at the end of axion-driven inflation where the axion is coupled to an Abelian, $U(1)$, gauge field via a Chern-Simons interaction term. We focus primarily on $m^2\\phi^2$ inflation and explore the possibility that preheating can occur for a range of coupling values consistent with recent observations and bounds on the overproduction of primordial black holes. We find that for a wide range of parameters preheating is efficient. In certain cases the inflaton is seen to transfer all its energy to the gauge fields within a few oscillations. We find that the gauge fields on sub-horizon scales end in an unpolarized state, due to the existence of strong rescattering between the inflaton and gauge modes. We also present a preliminary study of an axion monodromy model coupled to $U(1)$ gauge fields, seeing a similarly efficient preheating behavior as well as indications that the coupling strength has an effect on the creation of oscillons.

  6. Gravitational Waves from Preheating in M-flation

    CERN Document Server

    Ashoorioon, Amjad; Mann, Robert B; Oltean, Marius; Sheikh-Jabbari, M M

    2014-01-01

    Matrix inflation, or M-flation, is a string theory motivated inflationary model with three scalar field matrices and gauge fields in the adjoint representation of the $\\mathbf{U}(N)$ gauge group. One of these $3N^2$ scalars appears as the effective inflaton while the rest of the fields (scalar and gauge fields) can play the role of isocurvature fields during inflation and preheat fields afterwards. There is a region in parameter space and initial field values, "the hilltop region," where predictions of the model are quite compatible with the recent \\textit{Planck} data. We show that in this hilltop region, if the inflaton ends up in the supersymmetric vacuum, the model can have an embedded preheating mechanism. % only if inflation happens around the supersymmetric vacuum. % Couplings of the preheat modes are related to the inflaton self-couplings and therefore are known from the CMB data. Through lattice simulations performed using a symplectic integrator, we numerically compute the power spectra of gravitati...

  7. Picosecond laser ablation of poly-L-lactide: Effect of crystallinity on the material response

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz, Rocio; Quintana, Iban; Etxarri, Jon [Manufacturing Processes Department, Fundacion TEKNIKER, Av. Otaola 20, 20600, Eibar, Guipuzcoa (Spain); Lejardi, Ainhoa; Sarasua, Jose-Ramon [Department of Mining and Metallurgy Engineering and Materials Science, School of Engineering, University of the Basque Country (EHU-UPV), Alameda de Urquijo s/n, 48013 Bilbao (Spain)

    2011-11-01

    The picosecond laser ablation of poly-L-lactide (PLLA) as a function of laser fluence and degree of crystallinity was examined. The ablation parameters and the surface modifications were analyzed under various irradiation conditions using laser wavelengths ranging from the ultraviolet through the visible. When processing the amorphous PLLA, both energy threshold and topography varied considerably depending on laser wavelength. Laser irradiation showed a reduction in the energy ablation threshold as the degree of crystallinity increased, probably related to photomechanical effects involved in laser ablation with ultra-short pulses and the lower stress accommodation behavior of semicrystalline polymers. In particular, cooperative chain motions are impeded by the higher degree of crystallinity, showing fragile mechanical behavior and lower energy dissipation. The experimental results on ablation rate versus laser energy showed that UV laser ablation on semicrystalline PLLA was more efficient than the visible ablation, i.e., it exhibits higher etch rates over a wide range of pulse energy conditions. These results were interpreted in terms of photo-thermal and photo-chemical response of polymers as a function of material micro-structure and incident laser wavelength. High quality micro-grooves were produced in amorphous PLLA, reveling the potential of ultra-fast laser processing technique in the field of micro-structuring biocompatible and biodegradable polymers for biomedical applications.

  8. Effect of pre-heat treatments and cold rolling reduction on recrystallization texture of 6082 aluminum alloy%预处理和变形量对6082铝合金再结晶织构的影响

    Institute of Scientific and Technical Information of China (English)

    江海涛; 孙璐; 蔡正旭; 张成刚

    2013-01-01

    采用取向分布函数法分析并研究了冷轧前预处理和冷轧变形量对6082铝合金再结晶的影响.结果表明,6082铝合金的再结晶织构主要由立方织构和旋转立方织构组成.不经过热处理和经过固溶时效处理的试样,随着冷轧变形量的增加,再结晶织构组分明显增加;只经过固溶处理的试样,随着冷轧变形量的增加,再结晶织构组分变化不明显,说明冷轧前固溶处理可以明显弱化再结晶织构.%Effects of pre-heat treatments and cold rolling reduction on recrystallization texture of 6082 aluminum alloy were investigated by ODF (orientation distribution function).The results show that the recrystallization textures of 6082 aluminum alloy consist of cube texture and rotated cube texture components.For the samples without pre-heat treatment and overaging treatment,the recrystallization textures obviously increase with the increasing cold rolling reduction.However,the recrystallization textures change little with the increasing of cold rolling reduction for the solution-treated samples.The process of solution treatment before cold rolling can weaken the recrystallization texture of 6082 aluminum alloy.

  9. Temperature equilization in the Luetzkendorf preheater

    Energy Technology Data Exchange (ETDEWEB)

    1943-01-30

    Suggestions are offered for improvement to attain more nearly uniform temperature distribution in the preheater inlet and outlet as well as for improvement of a loss of pressure in heating gas for raising the efficiency of the heating gas blower. The evaluation of the operating conditions from the standpoint of the heating gas were made in the hydrogenation works of Poelitz, in 1939 with the preheater constructed on the Ludwigshafen plan, and in Luetzkendorf on the preheater of the Leuna model. Both preheaters had two Schiele heating gas blowers of the type 1160. Operating conditions involving hairpin tubes, temperatures, resistance, volume, piping, pressure, and heat conduction were given for both plants. A sketch for the heating gas movement was mentioned in the report but was not included. Recommendations on the use of a new blower were given. Some of these were reducing the yield to 90,000 cubic meters per hour and using the same motors. The distribution of the amounts and of the temperature drop of the gas and of the material of the hairpins were given.

  10. Combustion and Vibration Analysis of Idi- Diesel Engine Fuelled With Neat Preheated Jatropha Methyl Ester

    Directory of Open Access Journals (Sweden)

    Y.Ashok Kumar Reddy

    2014-03-01

    Full Text Available Experimentation is conducted on an IDI diesel engine and the results of combustion and vibration on IDI -Diesel engine fueled with the preheated Jatropha Methyl Ester (JME are presented. The Present research trend is to replace conventional diesel by renewable alternative fuels in view of fast depletion of petroleum reserves and to reduce the exhaust emissions from the engines without altering the basic design of the engine. Due to moderately higher viscosity effects, the direct use of biodiesel in C.I. engines is limited to 20% and the limitation is based on the NO emission also. In this work, the biodiesel is preheated using on line electronically controlled electrical preheating system before it enters into the injector. Experiments are conducted on a four stroke single cylinder IDI engine to find combustion and vibration characteristics of the engine with the preheated Jatropha Methyl Ester (JME heated to temperatures viz. 60,70,80,90 and 1000C. Normally thin oils due to heating may trigger fast burning leading to either detonation or knocking of the engine. This can be predicted by recording vibration on the cylinder head in different directions. The cylinder vibrations in the form of FFT and time waves have been analyzed to estimate the combustion propensity. Experiments are done using diesel, biodiesel and biodiesel at different preheated temperatures and for different engine loading conditions keeping the speed constant at 1500 rpm. Biodiesel preheated to 600C proved encouraging in all respects.

  11. Low-energy electron irradiation of preheated and gas-exposed single-wall carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Ecton, P.A. [Department of Physics, University of North Texas, Denton, TX 76203 (United States); Beatty, J.; Verbeck, G. [Department of Chemistry, University of North Texas, Denton, TX 76203 (United States); Lakshantha, W.; Rout, B. [Department of Physics, University of North Texas, Denton, TX 76203 (United States); Perez, J.M., E-mail: jperez@unt.edu [Department of Physics, University of North Texas, Denton, TX 76203 (United States)

    2016-11-30

    Highlights: • Preheating SWCNTs in situ before irradiation prevents an increase in the D peak. • Preheated SWCNTs exposed to air or gases before irradiation show an increase in D peak. • The increase in D peak is not due to irradiation-induced chemisorption of adsorbates. • The effects are more significant for small diameter SWCNTs. • The increase in D peak is attributed to defects that increase inter-tube interactions. - Abstract: We investigate the conditions under which electron irradiation at 2 keV of single-wall carbon nanotube (SWCNT) bundles produces an increase in the Raman D peak. We find that irradiation of SWCNTs that are preheated in situ at 600 °C for 1 h in ultrahigh vacuum before irradiation does not result in an increase in the D peak. Irradiation of SWCNTs that are preheated in vacuum and then exposed to air or gases results in an increase in the D peak, suggesting that adsorbates play a role in the increase in the D peak. Small diameter SWCNTs that are not preheated or preheated and then exposed to air show a significant increase in the D and G bands after irradiation. X-ray photoelectron spectroscopy shows no chemical shifts in the C 1s peak of SWCNTs that have been irradiated versus SWCNTs that have not been irradiated, suggesting that chemisorption of adsorbates is not responsible for the increase in the D peak.

  12. Microwave pre-heating of natural rubber using a rectangular wave guide (MODE: TE10

    Directory of Open Access Journals (Sweden)

    Doo-ngam, N.

    2007-11-01

    Full Text Available This paper presents an application of microwave radiation for pre-heating of natural rubbercompounding with various sulphur contents. The natural rubber-compounding was pre-heated by microwave radiation using a rectangular wave guide system (MODE: TE10 operating at frequency of 2.45 GHz in which the power can vary from 0 to 1500 W. In the present work, the influence of power input, sample thickness, and sulphur content were examined after applying microwave radiation to the rubber samples. Results are discussed regarding the thermal properties, 3-D network, dielectric properties and chemical structures. From the result, firstly, it was found that microwave radiation can be applied to pre-heating natural rubber-compounding before the vulcanization process. Secondly, microwave radiation was very useful for pre-heating natural rubber-compounding that has a thickness greater than 5mm. Thirdly, crosslinking in natural rubber-compounding may occurs after pre-heating by microwave radiation though Fourier Transform Infrared Spectroscopy(FTIR. Finally, there a little effect of sulphur content on temperature profiles after applying microwave radiation to the natural rubber-compounding. Moreover, natural rubber-compounding without carbon black showed a lower heat absorption compared with natural rubbercompounding filled carbon black. This is due to the difference in dielectric loss factor. This preliminary result will be useful information in terms of microwave radiation for pre-heating natural rubber-compounding and rubber processing in industry.

  13. Image-guided radiofrequency ablation of hepatocellular carcinoma (HCC): Is MR guidance more effective than CT guidance?

    Energy Technology Data Exchange (ETDEWEB)

    Clasen, Stephan, E-mail: stephan.clasen@med.uni-tuebingen.de [University Hospital, Department of Diagnostic and Interventional Radiology, Hoppe-Seyler Str. 3, 72076 Tübingen (Germany); Rempp, Hansjörg, E-mail: hansjoerg.rempp@med.uni-tuebingen.de [University Hospital, Department of Diagnostic and Interventional Radiology, Hoppe-Seyler Str. 3, 72076 Tübingen (Germany); Hoffmann, Rüdiger, E-mail: ruediger.hoffmann@med.uni-tuebingen.de [University Hospital, Department of Diagnostic and Interventional Radiology, Hoppe-Seyler Str. 3, 72076 Tübingen (Germany); Graf, Hansjörg, E-mail: hansjoerg.graf@med.uni-tuebingen.de [University Hospital, Department of Diagnostic and Interventional Radiology, Section of Experimental Radiology, Hoppe-Seyler Str. 3, 72076 Tübingen (Germany); Pereira, Philippe L., E-mail: Philippe.Pereira@slk-kliniken.de [SLK Clinic Heilbronn, Clinic for Radiology, Minimal-invasive Therapies, and Nuclear Medicine, Am Gesundbrunnen 20-26, 74078 Heilbronn (Germany); Claussen, Claus D., E-mail: claus.claussen@med.uni-tuebingen.de [University Hospital, Department of Diagnostic and Interventional Radiology, Hoppe-Seyler Str. 3, 72076 Tübingen (Germany)

    2014-01-15

    Objectives: The purpose of the study was to retrospectively compare technique effectiveness of computed tomography (CT)-guided versus magnetic resonance (MR)-guided radiofrequency (RF) ablation of hepatocellular carcinoma (HCC). Materials and methods: In 35 consecutive patients 53 CT-guided (n = 29) or MR-guided (n = 24) ablation procedures were performed in the treatment of 56 (CT: 29; MR: 27) HCC. The entire ablation procedure was performed at a multislice CT-scanner or an interventional 0.2-Tesla MR-scanner. Assessment of treatment response was based on dynamic MR imaging at 1.5 Tesla. The mean follow-up was 22.9 months. Primary technique effectiveness was assessed 4 months after ablation therapy. Secondary technique effectiveness was assessed 4 months after a facultative second ablation procedure. Primary and secondary technique effectiveness of CT-guided and MR-guided RF ablation was compared by using Chi-Square (likelihood ratio) test. Results: Primary technique effectiveness after a single session was achieved in 26/27 (96.3%) HCC after MR-guided RF ablation and 23/29 (79.3%) HCC after CT-guided RF ablation (Chi-Square: p = 0.04). Secondary technique effectiveness was achieved in 26/27 (96.3%) HCC after MR-guided RF ablation and in 26/29 (89.7%) HCC after CT-guided RF ablation (Chi-Square: p = 0.32). A local tumor progression was detected in 8/52 (15.4%) tumors after initial technique effectiveness. Major complications were detected after 3/53 (5.7%) ablation procedures. Conclusions: CT-guided and MR-guided RF ablations are locally effective therapies in the treatment of HCC. Due to a higher rate of primary technique effectiveness MR-guided RF ablation may reduce the number of required sessions for complete tumor treatment.

  14. The combined effect of radiofrequency and ethanol ablation in the management of large hepatocellular carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Sakr, Ayman A. [Department of Radiation Sciences, Radiology Unit, Medical Research Institute, University of Alexandria, 165 Horreya Avenue, El Hadara, Alexandria (Egypt)]. E-mail: aymansakr12345@hotmail.com; Saleh, Alaa Ahmed [Department of Radiation Sciences, Radiology Unit, Medical Research Institute, University of Alexandria, 165 Horreya Avenue, El Hadara, Alexandria (Egypt); Moeaty, Amr Ali Abdel [Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria (Egypt); Moeaty, Ali Abdel [Department of Internal Medicine, Faculty of Medicine, University of Alexandria, Alexandria (Egypt)

    2005-06-01

    Only a small percentage of patients with large hepatocellular carcinoma (HCC) may benefit out of surgical resection. Thus, most of these patients are in need of a form of local control, such as ethanol ablation, transarterial chemoembolization (TACE), radiofrequency thermal ablation (RF), or laser induced thermotherapy (LITT). The purpose of this study was to assess the short-term effect of sequential RF and ethanol ablation in the management of large HCC (>5 cm). Our series included 40 patients with large HCC tumors (>5 cm in diameter). We adopted a protocol of overlapping RF applications, followed by repeated ethanol ablation sessions. Our results showed that the volume of tumor coagulative necrosis initially induced by RF has significantly risen after adjuvant ethanol ablation sessions (P < 0.001). Patients who achieved complete tumor necrosis after RF ablation were 52.5% of the series. This percent has jumped to 80% of the series at the end of the protocol. This indicates that such combined protocol is more effective than RF alone. Besides, it is valuable in reducing the number of RF sessions.

  15. The effects of ablation on the cross section of planetary envelopes at capturing planetesimals

    Science.gov (United States)

    Benvenuto, Omar G.; Brunini, Adrián

    2008-06-01

    We explore the cross section of giant planet envelopes at capturing planetesimals of different sizes. For this purpose we employ two sets of realistic planetary envelope models (computed assuming for the protoplanetary nebula masses of 10 and 5 times the mass of the minimum mass solar nebula), account for drag and ablation effects and study the trajectories along which planetesimals move. The core accretion of these models has been computed in the oligarchic growth regime [Fortier, A., Benvenuto, O.G., Brunini, A., 2007. Astron. Astrophys. 473, 311-322], which has also been considered for the velocities of the incoming planetesimals. This regime predicts velocities larger that those used in previous studies of this problem. As the rate of ablation is dependent on the third power of velocity, ablation is more important in the oligarchic growth regime. We compute energy and mass deposition, fractional ablated masses and the total cross section of planets for a wide range of values of the critical parameter of ablation. In computing the total cross section of the planet we have included the contributions due to mass deposited by planetesimals moving along unbound orbits. Our results indicate that, for the case of small planetary cores and low velocities for the incoming planetesimals, ablation has a negligible impact on the capture cross section in agreement with the results presented in Inaba and Ikoma [Inaba, S., Ikoma, M., 2003. Astron. Astrophys. 410, 711-723]. However for the case of larger cores and high velocities of the incoming planetesimals as predicted by the oligarchic growth regime, we find that ablation is important in determining the planetary cross section, being several times larger than the value corresponding ignoring ablation. This is so regardless of the size of the incoming planetesimals.

  16. Effects of pretreated polysulfonamide pulp on the ablation behavior of EPDM composites

    Energy Technology Data Exchange (ETDEWEB)

    Jia Xiaolong; Li Gang; Sui Gang; Li Peng; Yu Yunhua; Liu Haiyang [Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029 (China); Yang Xiaoping [Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029 (China)], E-mail: yangxp@mail.buct.edu.cn

    2008-12-20

    Excellent ablative properties of ethylene-propylene-diene elastomer (EPDM) composites were obtained by adding pretreated polysulfonamide pulp (PSA-pulp). The effects of pulp pretreatment and pulp content on the mechanical and ablative properties of PSA-pulp/EPDM composites were studied. Experimental results showed that the tensile strength decreased slightly and the ablative properties increased by 3 folds on addition of 10 phr pretreated PSA-pulp. This significant improvement in the ablative properties was attributed to the enhanced dispersion degree and improved interfacial adhesion of pretreated PSA-pulp to EPDM matrix, which were observed from scanning electron microscopy. The ablation behavior of pretreated PSA-pulp/EPDM composites was proposed in accordance with the characterizations of thermogravimetric analysis (TGA), energy disperse X-ray spectroscopy (EDS) and pyrolysis-gas chromatograph-mass spectrometry (Py-GC-MS). The carbonized PSA-pulp acted as a skeleton in retaining the char layer and reduced the material loss during the high temperature ablation.

  17. Spectroscopic Measurements of Target Preheating on OMEGA

    Energy Technology Data Exchange (ETDEWEB)

    Elton, R.C.; Griem, H.R.; Iglesias, E.J.

    2000-02-28

    The preheating of laser-heated microballoon targets has been measured by time-resolved x-ray and extreme ultraviolet (euv) spectroscopy on the 30 kJ, 351 nm, 60-beam laser-fusion system at the University of Rochester Laboratory for Laser Energetics. Thin coatings of aluminum overcoated with magnesium served as indicators. both the sequence of the x-ray line emission and the intensity of euv radiation were used to determine a preheating peaking at {approx} 10 ns prior to onset of the main laser pulse, with a power density {approx_equal}1% of the main pulse. The measurements are supported by numerical modeling. Further information is provided by absorption spectra from the aluminum coating, backlighted by continuum from the heated surface. The exact source of the preheating energy remains unknown at present, but most likely arrives from early laser leakage through the system. The present target diagnostic is particularly useful when all beams cannot be monitored directly at all laser wavelengths.

  18. Evaluation of proarrythmogenic effects after different techniques of radiofrequency catheter ablation of atrial fibrillation

    Directory of Open Access Journals (Sweden)

    С. Н. Артёменко

    2015-10-01

    Full Text Available To assess proarrythmogenic effects after different techniques of radiofrequency catheter ablation, 427 patients with paroxysmal, persistent, and long-standing persistent atrial fibrillation (AF were examined. The patients were randomized into four groups: antral pulmonary vein isolation (PVI (Group I, PVI plus roof line and mitral isthmus ablation (Group II, anatomic ablation of ganglionated plexuses (GP of the left atrium (Group III and GP plus PVI (Group IV. At the end of follow up (34,43,2 months the largest number of proarrythmogenic effects was observed in Group II, 24,8% (26 patients. In the remaining groups the percentage of proarrythmogenic effects did not exceed 11%, neither was there any significant difference among Groups I, III and IV. Thus, the creation of additional linear lesions in the left atrium is a predictor of proarrythmogenic effects during follow up.

  19. Parametric resonance of entropy perturbations in massless preheating

    Science.gov (United States)

    Moghaddam, Hossein Bazrafshan; Brandenberger, Robert H.; Cai, Yi-Fu; Ferreira, Elisa G. M.

    2015-07-01

    In this paper, we revisit the question of possible preheating of entropy modes in a two-field model with a massless inflaton coupled to a matter scalar field. Using a perturbative approximation to the covariant method we demonstrate that there is indeed a parametric instability of the entropy mode which then at second-order leads to exponential growth of the curvature fluctuation on super-Hubble scale. Back-reaction effects shut off the induced curvature fluctuations, but possibly not early enough to prevent phenomenological problems. This confirms previous results obtained using different methods and resolves a controversy in the literature.

  20. Preheating and entropy perturbations in axion monodromy inflation

    Energy Technology Data Exchange (ETDEWEB)

    McDonough, Evan; Moghaddam, Hossein Bazrafshan [Department of Physics, McGill University,Montréal, QC H3A 2T8 (Canada); Brandenberger, Robert H. [Department of Physics, McGill University,Montréal, QC H3A 2T8 (Canada); Institute for Theoretical Studies, ETH Zürich,CH-8092 Zürich (Switzerland)

    2016-05-04

    We study the preheating of gauge fields in a simple axion monodromy model and compute the induced entropy perturbations and their effect on the curvature fluctuations. We find that the correction to the spectrum of curvature perturbations has a blue spectrum with index n{sub s}=5/2. Hence, these induced modes are harmless for the observed structure of the universe. Since the spectrum is blue, there is the danger of overproduction of primordial black holes. However, we show that the observational constraints are easily satisfied.

  1. Preheating and Entropy Perturbations in Axion Monodromy Inflation

    CERN Document Server

    ,

    2016-01-01

    We study the preheating of gauge fields in a simple axion monodromy model and compute the induced entropy perturbations and their effect on the curvature fluctuations. We find that the correction to the spectrum of curvature perturbations has a blue spectrum with index $n_s = 5/2$. Hence, these induced modes are harmless for the observed structure of the universe. Since the spectrum is blue, there is the danger of overproduction of primordial black holes. However, we show that the observational constraints are easily satisfied.

  2. Irreversible Electroporation versus Radiofrequency Ablation: A Comparison of Local and Systemic Effects in a Small-Animal Model.

    Science.gov (United States)

    Bulvik, Baruch E; Rozenblum, Nir; Gourevich, Svetlana; Ahmed, Muneeb; Andriyanov, Alexander V; Galun, Eithan; Goldberg, S Nahum

    2016-08-01

    Purpose To compare both periablational and systemic effects of two mechanistically different types of ablation: thermal radiofrequency (RF) ablation and electroporative ablation with irreversible electroporation (IRE) in appropriately selected animal models. Materials and Methods Animal experiments were performed according to a protocol approved by the Animal Care Committee of Hebrew University. Female C57BL/6 mice (n = 165) were randomized to undergo either RF or IRE ablation of noncancerous normal liver. The inflammatory response, cell proliferation, interleukin 6 (IL-6) levels, and intactness of vessels in the liver were assessed at 6, 12, and 24 hours and at 3, 7, and 14 days after ablation (n = 122 for mechanistic experiments). Systemic effects were then assessed by comparing tumor formation in an Mdr2-knockout (KO) mouse model (n = 15) and tumor growth in a remote BNL 1ME hepatoma xenograft tumor (n = 28). Results were averaged and evaluated by using two-tailed t tests. Results Although RF ablation was associated with a well-defined periablational inflammatory rim, for IRE, the infiltrate penetrated the ablation zone, largely along persistently patent vessels. Peak IL-6 levels (6 hours after ablation) were 10 and three times higher than at baseline for IRE and RF, respectively (P RF ablation or sham operation (mean, 3.6 ± 1.3 [standard deviation] vs 2.4 ± 1.1 and 2.2 ± 0.8, respectively; P RF ablation and sham operation). For BNL 1ME tumors, both RF and IRE liver ablation reduced tumor growth, with a greater effect noted for IRE (1329 mm(3) ± 586 and 819 mm(3) ± 327 vs 2241 mm(3) ± 548 for sham operation; P RF ablation. These local changes of IRE induce more robust systemic effects, including both tumorigenic and immunogenic effects. (©) RSNA, 2016 Online supplemental material is available for this article.

  3. Effects of pin angle and preheating on temperature distribution during friction stir welding operation%搅拌摩擦焊接过程中搅拌针锥角和预热对温度分布的影响

    Institute of Scientific and Technical Information of China (English)

    R. KEIVANI; B. BAGHERI; F. SHARIFI; M. KETABCHI; M. ABBASI

    2013-01-01

    Friction stir welding (FSW) is applied extensively in industry for joining of nonferrous metals especially aluminum. A three-dimensional model based on finite element analysis was used to study the thermal characteristic of copper C11000 during the FSW process. The model incorporates the mechanical reaction of the tool and thermo-mechanical characteristics of the weld material, while the friction between the material and the probe and the shoulder serves as the heat source. It was observed that the predicted results about the temperature were in good compatibility with the experimental results. Additionally, it was concluded that the numerical method can be simply applied to measuring the temperature of workpiece just beneath the tool. The effects of preheating temperature and pin angle on temperature distribution were also studied numerically. The increase of pin angle enhances the temperature around the weld line, but preheating does not affect temperature distribution along the weld line considerably.%搅拌摩擦焊(FSW)被广泛应用在工业上,用来连接有色金属,尤其是铝合金。采用基于有限元分析的三维模型研究FSW过程中铜C11000的热特性。模型包含了搅拌头的机械作用和待焊接材料的热性能,以材料和搅拌针以及轴肩之间的摩擦作为热源。结果表明,温度的预测结果与实验结果具有良好的一致性。此外,数值模拟方法可以简单地应用于测量搅拌头下方工件的温度。研究了预热温度和搅拌针锥角对温度分布的影响。搅拌针锥角的增加可提高焊缝周围的温度,但预热不会影响焊缝周围的温度分布。

  4. Effect of percutaneous renal sympathetic nerve radiofrequency ablation in patients with severe heart failure.

    Science.gov (United States)

    Dai, Qiming; Lu, Jing; Wang, Benwen; Ma, Genshan

    2015-01-01

    This study aimed to investigate the clinical feasibility and effects of percutaneous renal sympathetic nerve radiofrequency ablation in patients with heart failure. A total of 20 patients with heart failure were enrolled, aged from 47 to 75 years (63±10 years). They were divided into the standard therapy (n = 10), and renal nerve radiofrequency ablation groups (n = 10). There were 15 males and 5 female patients, including 8 ischemic cardiomyopathy, 8 dilated cardiomyopathy, and 8 hypertensive cardiopathy. All of the patients met the criteria of New York Heart Association classes III-IV cardiac function. Patients with diabetes and renal failure were excluded. Percutaneous renal sympathetic nerve radiofrequency ablation was performed on the renal artery wall under X-ray guidance. Serum electrolytes, neurohormones, and 24 h urine volume were recorded 24 h before and after the operation. Echocardiograms were performed to obtain left ventricular ejection fraction at baseline and 6 months. Heart rate, blood pressure, symptoms of dyspnea and edema were also monitored. After renal nerve ablation, 24 h urine volume was increased, while neurohormone levels were decreased compared with those of pre-operation and standard therapy. No obvious change in heart rate or blood pressure was recorded. Symptoms of heart failure were improved in patients after the operation. No complications were recorded in the study. Percutaneous renal sympathetic nerve radiofrequency ablation may be a feasible, safe, and effective treatment for the patients with severe congestive heart failure.

  5. Effect of the pulse repetition rate on fiber-assisted tissue ablation

    Science.gov (United States)

    Kang, Hyun Wook

    2016-07-01

    The effect of the pulse repetition rate on ablation performance was evaluated ex vivo at various fiber sweeping speeds for an effective 532-nm laser prostatectomy. Three pulse repetition rates (7.5, 15, and 30 kHz) at 100 W were delivered to bovine liver tissue at three sweeping speeds (2, 4, and 6 mm/s) to achieve bulky tissue removal. Ablation performance was quantitatively compared in terms of the ablation volume and the coagulation thickness. The lowest pulse repetition rate of 7.5 kHz attained the highest ablation volume (101.5 ± 12.0 mm3) and the thinnest coagulation (0.7 ± 0.1 mm) along with superficial carbonization. The highest pulse repetition rate of 30 kHz was associated with the least tissue removal (65.8 ± 5.0 mm3) and the deepest thermal denaturation (1.1 ± 0.2 mm). Quantitative evaluations of laser parameters can be instrumental in facilitating ablation efficiency and maintaining hemostatic coagulation during treatment of large-sized benign prostate hyperplasia.

  6. Higgs vacuum metastability in primordial inflation, preheating, and reheating

    Science.gov (United States)

    Kohri, Kazunori; Matsui, Hiroki

    2016-11-01

    Current measurements of the Higgs boson mass and top Yukawa coupling suggest that the effective Higgs potential develops an instability below the Planck scale. If the energy scale of inflation is as high as the grand unified theory (GUT) scale, inflationary quantum fluctuations of the Higgs field can easily destabilize the standard electroweak vacuum and produce a lot of anti-de Sitter (AdS) domains. This destabilization during inflation can be avoided if a relatively large nonminimal Higgs-gravity or inflaton-Higgs coupling is introduced. Such couplings generate a large effective mass term for the Higgs, which can raise the effective Higgs potential and suppress the vacuum fluctuation of the Higgs field. After primordial inflation, however, such effective masses drops rapidly and the nonminimal Higgs-gravity or inflaton-Higgs coupling can cause large fluctuations of the Higgs field to be generated via parametric resonance, thus producing AdS domains in the preheating stage. Furthermore, thermal fluctuations of the Higgs field cannot be neglected in the proceeding reheating epoch. We discuss the Higgs vacuum fluctuations during inflation, preheating, and reheating, and show that the Higgs metastability problem is severe unless the energy scale of the inflaton potential is much lower than the GUT scale.

  7. Numerical Simulation of Jet Behavior and Impingement Characteristics of Preheating Shrouded Supersonic Jets

    Institute of Scientific and Technical Information of China (English)

    Guang-sheng WEI; Rong ZHU; Ting CHENG; Fei ZHAO

    2016-01-01

    As a novel supersonic j et technology,preheating shrouded supersonic j et was developed to deliver oxygen into molten bath efficiently and affordably.However,there has been limited research on the jet behavior and im-pingement characteristics of preheating shrouded supersonic j ets.Computational fluid dynamics (CFD)models were established to investigate the effects of main and shrouding gas temperatures on the characteristics of flow field and impingement of shrouded supersonic j et.The preheating shrouded supersonic j et behavior was simulated and meas-ured by numerical simulation and j et measurement experiment respectively.The influence of preheating shrouded su-personic j et on gas j et penetration and fluid flow in liquid bath was calculated by the CFD model which was validated against water model experiments.The results show that the uptrend of the potential core length of shrouded super-sonic j et would be accelerated with increasing the main and shrouding gas temperatures.Also,preheating supersonic j ets demonstrated significant advantages in penetrating and stirring the liquid bath.

  8. SRC-II slurry preheater technical uncertainties. Report for the technical data analysis program

    Energy Technology Data Exchange (ETDEWEB)

    1984-06-01

    This report reviews the performance, and draws conclusions therefrom, the coal slurry preheaters of the Ft. Lewis, Washington, Solvent Refined Coal (SRC) Pilot Plant in the following areas: Coking, Erosion Corrosion, Heat transfer and pressure drop effects. Using prudent engineering judgement it postulates how such conclusions should affect the design and operability of large preheaters in future commercial scale plants. Also a recommendation is made for a small scale research and development effort that should result in a much firmer preheater design for any future facility. This report should be read in conjunction with the Solvent Refined Coal (SRC) Final Report, and volumes 1 and 2 of Slurry Preheater Design, SRC-II Process and also Ft. Lewis Slurry Preheater Data Analysis, 1-1/2 Inch Coil by Gulf Science and Technology Company of Pittsburgh, Pennsylvania. The Pittsburg and Midway Coal Mining Co.'s background is based primarily on a racetrack shaped up-flow coil and these comments pertain specifically to a commercial heater of that type of design. 5 references, 12 figures, 1 table.

  9. Graphene patterning by nanosecond laser ablation: the effect of the substrate interaction with graphene

    Science.gov (United States)

    Pérez-Mas, Ana M.; Álvarez, Patricia; Campos, Nuria; Gómez, David; Menéndez, Rosa

    2016-08-01

    This paper focuses on the development of patterned graphene/substrate by means of green nanosecond pulse laser irradiation. Monolayer graphene samples supported on a Si/SiO2 substrate were patterned using 532 nm laser irradiation under fluence conditions ranging from 31 mJ cm-2 to 4240 mJ cm-2. Raman spectroscopy was used to investigate the effect of laser irradiation on the graphene. It was found that at 356 mJ cm-2 selective ablation of the graphene occurs. However, at fluence values above 1030 mJ cm-2 (when damage to the substrate is observed) no ablation of the graphene takes place. In contrast, its graphenic structure was found to have been modified. Only at fluence values where the ablation of the substrate occurs, is graphene eliminated in an area almost equivalent to that of the ablated substrate. In this case, additional damage to the graphene sheet edges is produced. The increment in the number of oxygenated functional groups in these regions, as measured by x-ray photoelectron spectroscopy (XPS), suggests that this damage is probably caused by thermal phenomena during the ablation of the substrate.

  10. The effects of grooming on a copper ablative coating: a six year study.

    Science.gov (United States)

    Tribou, Melissa; Swain, Geoffrey

    2017-07-01

    More than 90% of US Navy Ships are coated with copper ablative paint. These ships may spend long periods of time pier-side, which makes them vulnerable to fouling. Hull grooming has been proposed as a means of maintaining the coatings in an operational condition. This study investigated the effect of grooming on a copper ablative coating exposed statically for six years. Grooming was performed weekly or monthly with controls left ungroomed. The fouling community was visually assessed, dry film thickness measurements were taken to monitor coating loss, and the copper leaching rates were measured. It was found that weekly and monthly groomed surfaces reduced fouling, and the ungroomed surfaces became fully fouled. Coating loss was similar for weekly, monthly and ungroomed surfaces. The results suggest that grooming is a viable method for maintaining copper ablative coatings in a fouling-free condition without adverse increases in the total copper output.

  11. Wavelength effect on hole shapes and morphology evolution during ablation by picosecond laser pulses

    Science.gov (United States)

    Zhao, Wanqin; Wang, Wenjun; Li, Ben Q.; Jiang, Gedong; Mei, Xuesong

    2016-10-01

    An experimental study is presented of the effect of wavelength on the shape and morphology evolution of micro holes ablated on stainless steel surface by a 10 ps Q-switched Nd:VAN pulsed laser. Two routes of hole development are associated with the visible (532 nm) and near-infrared (1064 nm) laser beams, respectively. The evolution of various geometric shapes and morphological characteristics of the micro holes ablated with the two different wavelengths is comparatively studied for other given processing conditions such as a laser power levels and the number of pulses applied. Plausible explanations, based on the light-materials interaction associated with laser micromachining, are also provided for the discernable paths of geometric and morphological development of holes under laser ablation.

  12. Waste heat recovery at the glass industry with the intervention of batch and cullet preheating

    Directory of Open Access Journals (Sweden)

    Dolianitis Ioannis

    2016-01-01

    Full Text Available A promising option to reduce the specific energy consumption and CO2 emissions at a conventional natural gas fired container glass furnace deals with the advanced utilization of the exhaust gases downstream the air regenerators by means of batch and cullet preheating. A 3-dimensional computational model that simulates this process using mass and heat transfer equations inside a preheater has been developed. A case study for an efficient small-sized container glass furnace is presented dealing with the investigation of the impact of different operating and design configurations on specific energy consumption, CO2 emissions, flue gas energy recovery, batch temperature and preheater efficiency. In specific, the effect of various parameters is studied, including the preheater’s dimensions, flue gas temperature, batch moisture content, glass pull, combustion air excess and cullet fraction. Expected energy savings margin is estimated to 12-15%.

  13. The benefit of solid oxide fuel cells with integrated air pre-heater

    Energy Technology Data Exchange (ETDEWEB)

    Costamagna, P. [Univ. degli Studi di Genova, Fac. di Ingegneria, ISTIC, Inst. di Ingegneria Chimica e di Processo `G.B. Bonino`, Genova (Italy)

    1997-11-01

    A new design has recently been proposed in the field of solid oxide fuel cells, consisting of a traditional electrochemical cell integrated with a pre-heater. In this paper a simulation model for the rectangular planar solid oxide fuel cell with integrated air pre-heater is presented. A two-dimensional stack simulation is presented as well, one axis coincides with the fuel flow direction, the other with the stack height. Local quantities such as current density, gas and solid temperatures are reported and cell characteristics predicted. In a parameter study, effects of oxygen utilisation and heat-transfer conditions in the pre-heater on the local temperature distribution of the solid structure are considered. As a result, the benefit of the new cell design becomes evident when low air flow rates are applied. A further advantage associated with the reduced flow rate is the low air temperature at the inlet. (orig.)

  14. Corrosion leaking of preheater weldment in alumina factories

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li; CHEN Wen-mi; GONG Zhu-qing; LIU Hong-zhao

    2005-01-01

    Stress corrosion cracking (SCC) and anticorrosion measures of TU42C weld-joint were studied by constant load experiments and pickling experiments. The results show that in 40%(mass fraction) NaOH solution at 110 ℃, caustic SCC occurs in TU42C weld-joints at the applied potential of -1 020 mV(vs SCE) for 3 d while at the potential of -950 mV(vs SCE) for 10 d. All the cracks are intergranular. In the 10% sulfuric acid, the cracks have the most negative self-corrosion potential -432.5 mV(vs SCE) and are active to be further corroded by the acid. Because of the same corrosion behaviour as the lab weldment, preheater's cracking in alumina factories is attributed to the combining actions of previous caustic SCC in Bayer solutions and continuous acid corrosion by pickling with the addition of RD. The following measures are effective to prevent the corrosion failure of preheater, such as postweld heat treatment at 620 ℃ to relax the residual weld stress, addition of CC3 and L826 as the corrosion inhibitors to improve the pickling and cleaning by the high pressure water instead of by pickling.

  15. Effectiveness and safety of simultaneous hybrid thoracoscopic and endocardial catheter ablation of lone atrial fibrillation

    NARCIS (Netherlands)

    Pison, Laurent; Gelsomino, Sandro; Lucà, Fabiana; Parise, Orlando; Maessen, Jos G; Crijns, Harry J G M; La Meir, Mark

    2014-01-01

    BACKGROUND: We evaluated the safety and effectiveness of the hybrid thoracoscopic endocardial epicardial technique for the treatment of lone atrial fibrillation. METHODS: Between 2009 and 2012, a cohort of 78 consecutive patients (median age 60.5 years, 77% male) underwent ablation of atrial fibrill

  16. Aspects of wave turbulence in preheating

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Henrique P. de; Crespo, Jose A. de A. [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil)

    2013-07-01

    Full text: In the simplest chaotic inflationary model, the Universe has an exponentially fast expansion phase driven by a single scalar field. After inflation, the preheating phase takes place. This phase is characterized when the inflaton performs coherent oscillations about its minimum value and is followed by a huge production of particles. In other terms, there is an energy transfer to small inhomogeneous fluctuations of the inflaton field. The long term behavior ends up in a thermalized universe. In this paper, we have studied numerically the late stages of preheating in a model with a quartic potential V (ϕ) = ¼λ ϕ{sup 4}. We have considered the universe as a squared box with periodic boundary conditions, and applied the collocation method to integrate the field equations. We have shown that the dynamics of the inflaton together with its initially small fluctuations is extremely rich. In the first stage, the parametric resonance is responsible for the exponential growth of some modes. In the sequence, the back reaction of these resonant modes triggers the transfer of energy to other modes or fluctuations. Subsequently, the transfer of energy from the inflaton to thermalize the universe is typical of a turbulent system. In the last part, we have considered the back reaction of the inflaton field in the expansion of the universe. (author)

  17. Co:MgF2 laser ablation of tissue: effect of wavelength on ablation threshold and thermal damage.

    Science.gov (United States)

    Schomacker, K T; Domankevitz, Y; Flotte, T J; Deutsch, T F

    1991-01-01

    The wavelength dependence of the ablation threshold of a variety of tissues has been studied by using a tunable pulsed Co:MgF2 laser to determine how closely it tracks the optical absorption length of water. The Co:MgF2 laser was tuned between 1.81 and 2.14 microns, a wavelength region in which the absorption length varies by a decade. For soft tissues the ablation threshold tracks the optical absorption length; for bone there is little wavelength dependence, consistent with the low water content of bone. Thermal damage vs. wavelength was also studied for cornea and bone. Thermal damage to cornea has a weak wavelength dependence, while that to bone shows little wavelength dependence. Framing-camera pictures of the ablation of both cornea and liver show explosive removal of material, but differ as to the nature of the explosion.

  18. Effects of picosecond laser repetition rate on ablation of Cr12MoV cold work mold steel

    Science.gov (United States)

    Wu, Baoye; Deng, Leimin; Liu, Peng; Zhang, Fei; Duan, Jun; Zeng, Xiaoyan

    2017-07-01

    In this paper, the effects of pulse repetition rate on ablation efficiency and quality of Cr12MoV cold work mold steel have been studied using a picosecond (ps) pulse Nd:YVO4 laser system at λ= 1064 nm. The experimental results of area ablation on target surface reveal that laser repetition rate plays a significant role in controlling ablation efficiency and quality. Increasing the laser repetition rate, while keeping a constant mean power improves the ablation efficiency and quality. For each laser mean power, there is an optimal repetition rate to achieve a higher laser ablation efficiency with low surface roughness. A high ablation efficiency of 42.29, 44.11 and 47.52 μm3/mJ, with surface roughness of 0.476, 0.463 and 0.706 μm could be achieved at laser repetition rate of 10 MHz, for laser mean power of 15, 17 and 19 W, respectively. Scanning electron microcopy images revels that the surface morphology evolves from rough with numerous craters, to flat without pores when we increased the laser repetition rate. The effects of laser repetition rate on the heat accumulation, plasma shield and ablation threshold were analyzed by numerical simulation, spectral analysis and multi-laser shot, respectively. The synergetic effects of laser repetition rate on laser ablation rate and machining quality were analyzed and discussed systemically in this paper.

  19. Effects of repeated use and resterilization on structural and functional integrity of microwave ablation antennas.

    Science.gov (United States)

    Finck, Cyrielle A; Zur Linden, Alex R; Singh, Ameet; Foster, Robert A; Nykamp, Stephanie G; Sears, William C

    2017-04-01

    OBJECTIVE To determine effects of repeated use and resterilization on structural and functional integrity of microwave ablation (MWA) antennas. SAMPLE 17 cooled-shaft MWA antennas (3 groups of 5 antennas/group and 2 control antennas). PROCEDURES 1, 2, and 3 ablations in the livers of bovine cadavers were performed at the maximum recommended settings. Antennas were cleaned and sterilized in hydrogen peroxide plasma, and the process was repeated (reprocessing cycle; n = 6). Control antennas were only sterilized (6 times). Aerobic and anaerobic bacterial cultures were performed, and antennas were microscopically assessed for damage. RESULTS 6 cycles were completed. Thirteen of 15 MWA antennas remained functional for up to 4 cycles, 10 were functional after 5 cycles, and only 7 were functional after 6 cycles. Progressive tearing of the silicone coating of the antennas was observed, with a negative effect of the number of cycles for silicone tearing. Size of the ablation zone decreased mildly over time after cycles 5 and 6; however, this was not considered clinically relevant. No significant changes in the shape of ablation zones were detected. All cultures yielded negative results, except for an isolated case, which was considered a contaminant. CONCLUSIONS AND CLINICAL RELEVANCE Structural and functional integrity of the microwave antennas remained acceptable during repeated use and reprocessing for up to 4 cycles. However, there was a decrease in functional integrity at cycles 5 and 6. We suggest that these microwave antennas be subjected to > 3 reprocessing cycles. Antennas should be carefully examined before reuse.

  20. Effect of telencephalon ablation on the reinforcing and eliciting properties of species-specific events in Betta splendens.

    Science.gov (United States)

    Hollis, K L; Overmier, J B

    1982-08-01

    In male Betta splendens, aggressive behavior is drastically attenuated following telencephalon ablation. Because instrumental training and Pavlovian conditioning experiments with intact fish have suggested that associative factors may play an important role in the performance of agonistic behaviors, the effect of ablation on instrumental learning and Pavlovian conditioning was studied. In Experiment 1, ablation had no effect on the learning of the instrumental tunnel-swimming response reinforced by mirror presentation (i.e., viewing a conspecific), although the mirror presentations in yoked-control groups elicited fewer responses in ablates than in normal and sham-operated control fish. Yoked controls further established that instrumental responding was maintained by the reinforcement contingency and was not merely the result of increased motor activity. Experiment 2 studied Pavlovian conditioning of the components of the agonistic display. Unconditioned fin erection, gill erection, and tail beating (i.e., unconditioned responses, URs) to the mirror US all were less frequent in ablates than in normals or shams. Of these, only gill cover erection showed evidence of true conditioning (i.e., conditioned responses; CRs) in which responses to the conditioned stimulus (CS) are due to the pairings of CS and US (unconditioned stimulus). However, ablates suffered no impairment of conditioned gill erections. Ablates performed fewer fin erections to the CS; however, fin erection responses were not due to CS-US pairings but were attributable to pseudoconditioning. These results are related to hypotheses postulating the involvement of learning mechanisms in ablation-produced deficits and normal aggressive behavior.

  1. Curative effect and mechanism of radiofrequency ablation nucleoplasty in the treatment of cervical vertigo.

    Science.gov (United States)

    Yin, Hai-Dong; Zhang, Xin-Mei; Huang, Ming-Guang; Chen, Wei; Song, Yang; Du, Qing-Jun; Wu, Yu-Ning; Yang, Ruo-Bin

    2017-04-01

    This study aims to investigate the curative effects and mechanism of radiofrequency ablation nucleoplasty in the treatment of cervical vertigo. A total of 27 patients diagnosed with cervical vertigo from January 2012 to October 2014 received treatment of radiofrequency ablation nucleoplasty. The narrow-side vertebral artery diameters were examined by using Philips 1.5-T body dual-gradient MRI system. The haemodynamic parameters were detected by using transcranial Doppler sonography. Both of the vertebral artery diameters and haemodynamic parameters were recorded and compared before and after treatment. The curative effects in early post-operative application were evaluated according to the Nagashima standards. Radiofrequency ablation nucleoplasty was performed in a total of 59 cervical discs in 27 patients. The average operation time was 42.7 min, and the symptoms of 92.6% patients were alleviated after radiofrequency ablation nucleoplasty post-operation application. There was no significant difference in the narrow-side vertebral artery diameters before and after treatment in both Group A (p = 0.12) and Group B (p = 0.48); however, the blood flow velocity was significantly higher than that before treatment in both Group A (p = 0.01) and Group B (p = 0.03), respectively. Radiofrequency ablation nucleoplasty improves the blood flow in the narrow-side vertebral artery and illustrates the therapeutic effect on cervical vertigo in patients who have no direct compression of the vertebral artery. Advances in knowledge: Radiofrequency intradiscal nucleoplasty can be used as a minimally invasive procedure for treating cervical vertigo.

  2. Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: A prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xin [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Zou, Min; Zhang, Cai [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); He, Jia [Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000 (China); Mao, Shihua [Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000 (China); Wu, Qingrong [Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099 (China); He, Min [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000 (China); Wang, Jian [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000 (China); Zhang, Ruitao [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099 (China); Zhang, Lian, E-mail: lianwzhang@yahoo.com [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China)

    2014-09-15

    Objective: To investigate the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis. Materials and methods: Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment. During HIFU treatment, 80 units of oxytocin was added in 500 ml of 0.9% normal saline running at the rate of 2 ml/min (0.32 U/min) in the oxytocin group, while 0.9% normal saline was used in the control group. Both patients and HIFU operators were blinded to oxytocin or saline application. Treatment results, adverse effects were compared. Results: When using oxytocin, the non-perfused volume (NPV) ratio was 80.7 ± 11.6%, the energy-efficiency factor (EEF) was 8.1 ± 9.9 J/mm{sup 3}, and the sonication time required to ablate 1 cm{sup 3} was 30.0 ± 36.0 s/cm{sup 3}. When not using oxytocin, the non-perfused volume ratio was 70.8 ± 16.7%, the EEF was 15.8 ± 19.6 J/mm{sup 3}, and the sonication time required to ablate 1 cm{sup 3} was 58.2 ± 72.7 S/cm{sup 3}. Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1 cm{sup 3} between the two groups was observed. No oxytocin related adverse effects occurred. Conclusion: Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU, safely enhance the treatment efficiency.

  3. Ions Preheated in 3He-Rich Solar Particle Events

    Institute of Scientific and Technical Information of China (English)

    王德焴

    2003-01-01

    A wave-particle resonance absorption model in the two-ion plasma is suggested in explanation to the coronal ions preheating in 3He-rich solar particle events. It is found that 3He and Fe ions are preferably preheated by the ion-ion hybrid waves at their fundamental and second harmonic ion cyclotron frequencies, respectively.

  4. Bringing coal preheating in drum dryers to a commercial level

    Energy Technology Data Exchange (ETDEWEB)

    Babanin, B.I.; Proushin, Yu.E.; Dinel' t, V.M.; Nikolaeva, V.Z.; Shabarshova, Yu.V.; Patrushev, A.N.; Vodop' yanov, A.G.; Vlasov, V.S.; Sementin, V.P.

    1988-10-01

    Discusses operation of a system for coal charge preheating used in Western Siberia since 1965. It is the first coal preheating system constructed in the USSR. The following aspects of system operation are discussed: composition of combustion gases used for coal drying, drying temperature, consumption rate of combustion gases depending on coal moisture content, flue gas recirculation system, transport and storage of dried coal, methods for dust separation (wet and dry), air pollution from coal dryers, and efficiency of air pollution control. Operation of the coal preheating system shows that one-stage coal drying and preheating is economic but associated with increased investment (construction cost) and with increased coal comminution. Large one-stage dryers also cause irregular coal preheating depending on distribution of coal grain size (with overheating of coal fines). Recommendations for design modifications of one-stage dryers are made. 3 refs.

  5. Fate of Electroweak Vacuum during Preheating

    CERN Document Server

    Ema, Yohei; Nakayama, Kazunori

    2016-01-01

    Our electroweak vacuum may be metastable in light of the current experimental data of the Higgs/top quark mass. If this is really the case, high-scale inflation models require a stabilization mechanism of our vacuum during inflation. A possible candidate is the Higgs-inflaton/-curvature coupling because it induces an additional mass term to the Higgs during the slow roll regime. However, after the inflation, the additional mass term oscillates, and it can potentially destabilize our electroweak vacuum via production of large Higgs fluctuations during the inflaton oscillation era. In this paper, we study whether or not the Higgs-inflaton/-curvature coupling can save our vacuum by properly taking account of Higgs production during the preheating stage. We put upper bounds on the Higgs-inflaton/-curvature coupling, and discuss possible dynamics that might relax them.

  6. QUENCH STUDIES AND PREHEATING ANALYSIS OF SEAMLESS

    Energy Technology Data Exchange (ETDEWEB)

    Palczewski, Ari [JLAB; Geng, Rongli [JLAB; Eremeev, Grigory [JLAB

    2013-09-01

    One of the alternative manufacturing technologies for SRF cavities is hydroforming from seamless tubes. Although this technology has produced cavities with gradient and Q-values comparable to standard EBW/EP cavities, a few questions remain. One of these questions is whether the quench mechanism in hydroformed cavities is the same as in standard electron beam welded cavities. Towards this effort Jefferson Lab performed quench studies on 2 9 cell seamless hydroformed cavities. These cavities include DESY's - Z163 and Z164 nine-cell cavities hydroformed at DESY. Initial Rf test results Z163 were published in SRF2011. In this report we will present post JLAB surface re-treatment quench studies for each cavity. The data will include OST and T-mapping quench localization as well as quench location preheating analysis comparing them to the observations in standard electron beam welded cavities.

  7. Frustration of resonant preheating by exotic kinetic terms

    Energy Technology Data Exchange (ETDEWEB)

    Rahmati, Shohreh; Seahra, Sanjeev S., E-mail: srahmati@unb.ca, E-mail: sseahra@unb.ca [Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB, E3B 5A3 Canada (Canada)

    2014-10-01

    We study the effects of exotic kinetic terms on parametric resonance during the preheating epoch of the early universe. Specifically, we consider modifications to the action of ordinary matter fields motivated by generalized uncertainty principles, polymer quantization, as well as Dirac-Born-Infeld and k-essence models. To leading order in an ''exotic physics'' scale, the equations of motion derived from each of these models have the same algebraic form involving a nonlinear self-interaction in the matter sector. Neglecting spatial dependence, we show that the nonlinearity effectively shuts down the parametric resonance after a finite time period. We find numeric evidence that the frustration of parametric resonance persists to spatially inhomogenous matter in (1+1)-dimensions.

  8. Research on a Household Dual Heat Source Heat Pump Water Heater with Preheater Based on ASPEN PLUS

    Directory of Open Access Journals (Sweden)

    Xiang Gou

    2016-12-01

    Full Text Available This article proposes a dual heat source heat pump bathroom unit with preheater which is feasible for a single family. The system effectively integrates the air source heat pump (ASHP and wastewater source heat pump (WSHP technologies, and incorporates a preheater to recover shower wastewater heat and thus improve the total coefficient of performance (COP of the system, and it has no electric auxiliary heating device, which is favorable to improve the security of the system operation. The process simulation software ASPEN PLUS, widely used in the design and optimization of thermodynamic systems, was used to simulate various cases of system use and to analyze the impact of the preheater on the system. The average COP value of a system with preheater is 6.588 and without preheater it is 4.677. Based on the optimization and analysis, under the standard conditions of air at 25 °C, relative humidity of 70%, wastewater at 35 °C, wastewater flow rate of 0.07 kg/s, tap water at 15 °C, and condenser outlet water temperature at 50 °C, the theoretical COP of the system can reach 9.784 at an evaporating temperature of 14.96 °C, condensing temperature of 48.74 °C, and preheated water temperature of 27.19 °C.

  9. Assessing the 2{omega}{sub pe} instability and other preheat considerations in ignition-scale hohlraums

    Energy Technology Data Exchange (ETDEWEB)

    Kruer, W L [University of California, Davis, Davis, CA 95616 (United States); Meezan, Nathan; Town, Richard; Strozzi, David; Wilks, Scott; Williams, Edward; Meeker, Donald; Suter, L S [Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Regan, S P, E-mail: wlkruer@ucdavis.ed [Laboratory for Laser Energetics, Rochester, NY 14623 (United States)

    2010-08-01

    In recent experiments[1] Sean Regan, et. al. for the first time observed the 2{omega}{sub pe} instability from window plasma in hohlraum targets. This instability can also operate[2] at peak power near the edge of the inner beams in the ablator plasma and near the edge of the outer beams in the liner plasma. Fortunately only a small fraction of the laser energy was estimated to be at risk. A more quantitative assessment of the energy at risk at peak power will here be given. We show that the instability threshold can be significantly reduced for laser beams with an angle of incidence of about 60 degrees due to the swelling of the laser field near its turning point. A simple model is given. It is also shown that for frequently cited plasma conditions, the Raman-scattered light wave can itself drive the 2{omega}{sub pe}instability. This effect is relevant for the nonlinear saturation of stimulated Raman scattering (SRS) and the resulting heated electron generation. Some estimates are given. Finally we conclude with a few remarks about hot electron preheat.

  10. Enhanced preheating after multi-field inflation: on the importance of being special

    Energy Technology Data Exchange (ETDEWEB)

    Battefeld, Thorsten; Eggemeier, Alexander [Institute for Astrophysics, University of Goettingen, Friedrich Hund Platz 1, D-37077 Goettingen (Germany); Giblin, John T. Jr., E-mail: tbattefe@astro.physik.uni-goettingen.de, E-mail: a.eggemeier@stud.uni-goettingen.de, E-mail: giblinj@kenyon.edu [Department of Physics, Kenyon College, Gambier, OH 43022 (United States)

    2012-11-01

    We discuss preheating after multi-field inflation in the presence of several preheat matter fields that become light in the vicinity of (but not at) the inflatons' VEV, at distinct extra-species-points (ESP); this setup is motivated by inflationary models that include particle production during inflation, e.g. trapped inflation, grazing ESP encounters or modulated trapping, among others. While de-phasing of inflatons tends to suppress parametric resonance, we find two new effects leading to efficient preheating: particle production during the first in-fall (efficient if many preheat matter fields are present) and a subsequent (narrow) resonance phase (efficient if an ESP happens to be at one of several distinct distances from the inflatons' VEV). Particles produced during the first in-fall are comprised of many species with low occupation number, while the latter are made up of a few species with high occupation number. We provide analytic descriptions of both phases in the absence of back-reaction, which we test numerically. We further perform lattice simulations to investigate the effects of back-reaction. We find resonances to be robust and the most likely cause of inflaton decay in multi-field trapped inflation if ESP distributions are dense.

  11. The Accretion and Cooling of Preheated Gas in Dark Matter Halos

    CERN Document Server

    Lu, Y; Lu, Yu

    2006-01-01

    (abridged) We use a one-dimensional hydrodynamical code to investigate the effects of preheating on gas accretion and cooling in cold dark matter halos. In the absence of radiative cooling, preheating reduces the amount of gas that can be accreted into a halo, and the accreted gas fraction is determined by the ratio of the initial specific entropy of the gas to the virial entropy of the halo. In the presence of radiative cooling, preheating affects the gas fraction that can cool in two different ways. For small halos with masses 10^13Msun. We suggest that this may be the reason why the stellar mass function of galaxies breaks sharply at the massive end. Such preheating also helps create the hot diffused halos within which the "radio mode" feedback of AGNs can act effectively. In the second case, we assume the intergalactic medium is warm. Here the total amount of gas that can cool in a halo scales with halo mass as ~M^2, as would be required to match the observed stellar- and HI-mass functions in the current ...

  12. Bump evolution driven by the x-ray ablation Richtmyer-Meshkov effect in plastic inertial confinement fusion Ablators

    Directory of Open Access Journals (Sweden)

    Loomis Eric

    2013-11-01

    Full Text Available Growth of hydrodynamic instabilities at the interfaces of inertial confinement fusion capsules (ICF due to ablator and fuel non-uniformities are a primary concern for the ICF program. Recently, observed jetting and parasitic mix into the fuel were attributed to isolated defects on the outer surface of the capsule. Strategies for mitigation of these defects exist, however, they require reduced uncertainties in Equation of State (EOS models prior to invoking them. In light of this, we have begun a campaign to measure the growth of isolated defects (bumps due to x-ray ablation Richtmyer-Meshkov in plastic ablators to validate these models. Experiments used hohlraums with radiation temperatures near 70 eV driven by 15 beams from the Omega laser (Laboratory for Laser Energetics, University of Rochester, NY, which sent a ∼1.25Mbar shock into a planar CH target placed over one laser entrance hole. Targets consisted of 2-D arrays of quasi-gaussian bumps (10 microns tall, 34 microns FWHM deposited on the surface facing into the hohlraum. On-axis radiography with a saran (Cl Heα − 2.76keV backlighter was used to measure bump evolution prior to shock breakout. Shock speed measurements were also performed to determine target conditions. Simulations using the LEOS 5310 and SESAME 7592 models required the simulated laser power be turned down to 80 and 88%, respectively to match observed shock speeds. Both LEOS 5310 and SESAME 7592 simulations agreed with measured bump areal densities out to 6 ns where ablative RM oscillations were observed in previous laser-driven experiments, but did not occur in the x-ray driven case. The QEOS model, conversely, over predicted shock speeds and under predicted areal density in the bump.

  13. Effect of air breakdown with a focusing lens on ultrashort laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Hu Wenqian; Shin, Yung C.; King, Galen [School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907 (United States)

    2011-12-05

    The effect of air breakdown on ultrashort laser ablation is investigated in this letter using an integrated simulation method on atomistic level. The generation of air breakdown with different laser peak power densities in the range from 10{sup 13} to 10{sup 16} W/cm{sup 2} and various focusing conditions is analyzed. Air breakdown is generated directly from laser energy absorption through avalanche ionization at a high power density (over 10{sup 14} W/cm{sup 2}), while at a lower power density, air breakdown is assisted by a metal target near the focal region. The laser energy loss due to air breakdown and its effect on laser ablation are studied.

  14. Thermal infrared images to quantify thermal ablation effects of acid and base on target tissues

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Ran, E-mail: jliubme@tsinghua.edu.cn, E-mail: liuran@tsinghua.edu.cn; Liu, Jing, E-mail: jliubme@tsinghua.edu.cn, E-mail: liuran@tsinghua.edu.cn [Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084 (China); Wang, Jia [Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 (United States)

    2015-07-15

    Hyperthermia (42-46°C), treatment of tumor tissue through elevated temperature, offers several advantages including high cost-effectiveness, highly targeted ablation and fewer side effects and hence higher safety level over traditional therapies such as chemotherapy and radiotherapy. Recently, hyperthermia using heat release through exothermic acid-base neutralization comes into view owing to its relatively safe products of salt and water and highly confined ablation. However, lack of quantitative understanding of the spatial and temporal temperature profiles that are produced by simultaneous diffusion of liquid chemical and its chemical reaction within tumor tissue impedes the application of this method. This article is dedicated to quantify thermal ablation effects of acid and base both individually and as in neutralization via infrared captured thermal images. A theoretical model is used to approximate specific heat absorption rate (SAR) based on experimental measurements that contrast two types of tissue, normal pork and pig liver. According to the computation, both pork and liver tissue has a higher ability in absorbing hydrochloric acid (HCl) than sodium hydroxide, hence suggesting that a reduced dosage for HCl is appropriate in a surgery. The heating effect depends heavily on the properties of tissue types and amount of chemical reagents administered. Given thermal parameters such as SAR for different tissues, a computational model can be made in predicting temperature transitions which will be helpful in planning and optimizing surgical hyperthermia procedures.

  15. Thermal infrared images to quantify thermal ablation effects of acid and base on target tissues

    Directory of Open Access Journals (Sweden)

    Ran Liu

    2015-07-01

    Full Text Available Hyperthermia (42-46°C, treatment of tumor tissue through elevated temperature, offers several advantages including high cost-effectiveness, highly targeted ablation and fewer side effects and hence higher safety level over traditional therapies such as chemotherapy and radiotherapy. Recently, hyperthermia using heat release through exothermic acid-base neutralization comes into view owing to its relatively safe products of salt and water and highly confined ablation. However, lack of quantitative understanding of the spatial and temporal temperature profiles that are produced by simultaneous diffusion of liquid chemical and its chemical reaction within tumor tissue impedes the application of this method. This article is dedicated to quantify thermal ablation effects of acid and base both individually and as in neutralization via infrared captured thermal images. A theoretical model is used to approximate specific heat absorption rate (SAR based on experimental measurements that contrast two types of tissue, normal pork and pig liver. According to the computation, both pork and liver tissue has a higher ability in absorbing hydrochloric acid (HCl than sodium hydroxide, hence suggesting that a reduced dosage for HCl is appropriate in a surgery. The heating effect depends heavily on the properties of tissue types and amount of chemical reagents administered. Given thermal parameters such as SAR for different tissues, a computational model can be made in predicting temperature transitions which will be helpful in planning and optimizing surgical hyperthermia procedures.

  16. Ammonium bisulfate formation temperature in a bench-scale single-channel air preheater

    Energy Technology Data Exchange (ETDEWEB)

    J. Menasha; D. Dunn-Rankin; L. Muzio; J. Stallings [University of California Irvine, Irvine, CA (United States). Department of Mechanical and Aerospace Engineering

    2011-07-15

    Ammonium bisulfate (ABS) forms in coal-fired power plant exhaust systems when ammonia slip from the NOx control system reacts with the sulfur oxides and water in the flue gas. The critical temperature range for ABS formation occurs in the air preheater, where ABS is known to cause corrosion and pluggage that can require unplanned outages and expensive cleaning. To develop mitigation strategies for the deleterious effects of ABS in air preheaters, it is important to know its formation temperature and deposition process. This paper describes a bench-scale experimental simulation of a single-channel air preheater, with the appropriate temperature gradient, used in conjunction with simulated coal combustion flue gas, including sulfur oxides, ammonia, and water vapor, to investigate the formation of ABS. Formation was observed optically, and the formation temperature, as well as deposition characteristics for a realistic range of reactant concentrations are presented and compared with previous studies on ABS formation. This study presents data at realistic concentrations not earlier tested, and the reported data has smaller experimental uncertainty than previously obtained. We found that the measured ABS formation temperatures under air preheater channel conditions lies between the temperatures reported by others, and is in the range of 500-520 K for typical flue gas concentrations of ammonia and sulfur oxide species. The results also show that, at least for this experimental configuration, ABS forms predominantly as an aerosol in the gas phase rather than as a condensate on the channel walls. 13 refs., 13 figs., 2 tabs.

  17. Effect of Ablation on Heat Transfer & Performance of an Axisymmetric Supersonic Nozzle

    Science.gov (United States)

    Raza, M. A.

    The theoretical prediction of heat transfer effects in compressible turbulent flows is fundamentally complex phenomenon. Computational fluid dynamics (CFD) analysis is employed using Baldwin-Lomax turbulent model to simulate the effect of various nozzle geometry defects on the heat transfer state in supersonic nozzles. The study is done in terms of various heat transfer correlations and analogies by characteristic flow regimes numbers. Theses are calculated from modified Reynolds analogy for laminar flow over flat plate, the Dittus-Boelter correlation for fully developed turbulent flow, Sieder-Tate correlation for turbulent pipe flow with property variation and Bartz correlation for variable cross sections flow. In addition to these, modified Stanton correlation for high speed flows for pipe flow analogy is also used. The contribution of ablation on the formation of new nozzle contours at various regions is simulated using energy equation for charring ablators. The effect of heat transfer correlations on nozzle performance with various geometrical defects is also discussed. In addition to it, the supersonic flow behavior is also simulated in the nozzles in terms of pressure, temperature, Mach number and density distribution with ablated surfaces.

  18. Ablation effects of noninvasive radiofrequency field-induced hyperthermia on liver cancer cells

    Directory of Open Access Journals (Sweden)

    Kaiyun Chen

    2016-05-01

    Full Text Available To have in-depth analysis of clinical ablation effect of noninvasive radiofrequency field-induced hyperthermia on liver cancer cells, this paper collected liver cancer patients’ treatment information from 10 hospitals during January 2010 and December 2011, from which 1050 cases of patients were randomly selected as study object of observation group who underwent noninvasive radiofrequency field-induced hyperthermia treatment; in addition, 500 cases of liver cancer patients were randomly selected as study object of control group who underwent clinical surgical treatment. After treatment was completed, three years of return visit were done, survival rates of the two groups of patients after 1 year, 2 years, and 3 years were compared, and clinical effects of radiofrequency ablation of liver cancer were evaluated. Zoom results show that the two groups are similar in terms of survival rate, and the difference is without statistical significance. 125 patients in observation group had varying degrees of adverse reactions, while 253 patients in control group had adverse reactions. There was difference between groups P < 0.05, with significant statistical significance. It can be concluded that radiofrequency ablation of liver cancer is more secure. Therefore, the results of this study fully demonstrate that liver cancer treatment with noninvasive radiofrequency field-induced hyperthermia is with safety effect and satisfactory survival rate, thus with relatively high clinical value in clinical practice.

  19. Effect of nonionic surfactant addition on Pyrex glass ablation using water-assisted CO2 laser processing

    Science.gov (United States)

    Chung, C. K.; Liao, M. W.; Lin, S. L.

    2010-04-01

    Pyrex glass etching using laser ablation is an important technology for the microfluid application to lab-on-a-chip devices but suffers from the formation of surface crack. In this article, the addition of nonionic surfactant to water for glass ablation using water-assisted CO2 laser processing (WACLAP) has been investigated to enhance ablation rate and to eliminate conventional surface defects of cracks in air. WACLAP for Pyrex glass ablation can reduce thermal-stress-induced crack with water cooling and hydrophilic nonionic surfactant to water can enhance ablation performance. Compared to pure water, the 15% weight percent Lauramidopropyl Betaine surfactant solutions for WACLAP can enhance ablation rate from 13.6 to 25 μm/pass of Pyrex glass ablation at a linear laser energy density of 2.11 J/cm, i.e., 24 W power, 114 mm/s scanning speed, and obtain through-wafer etching at 3.16 J/cm for 20 passes without cracks on the surface. Effect of surfactant concentration and linear energy density on WACLAP was also examined. The possible mechanism of surfactant-enhanced phenomenon was discussed by the Newton’s law of viscosity of surfactant solution.

  20. Transrectal high-intensity focused ultrasound ablation of prostate cancer: Effective treatment requiring accurate imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Olivier.rouviere@netcourrier.com; Souchon, Remi [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: souchon@lyon.inserm.fr; Salomir, Rares [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: salomir@lyon.inserm.fr; Gelet, Albert [Hospices Civils de Lyon, Department of Urology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France)], E-mail: Albert.gelet@chu-lyon.fr; Chapelon, Jean-Yves [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: chapelon@lyon.inserm.fr; Lyonnet, Denis [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Denis.lyonnet@chu-lyon.fr

    2007-09-15

    Transrectal HIFU ablation has become a reasonable option for the treatment of localized prostate cancer in non-surgical patients, with 5-year disease-free survival similar to that of radiation therapy. It is also a promising salvage therapy of local recurrence after radiation therapy. These favourable results are partly due to recent improvements in prostate cancer imaging. However, further improvements are needed in patient selection, pre-operative localization of the tumor foci, assessment of the volume treated and early detection of recurrence. A better knowledge of the factors influencing the HIFU-induced tissue destruction and a better pre-operative assessment of them by imaging techniques should improve treatment outcome. Whereas prostate HIFU ablation is currently performed under transrectal ultrasound guidance, MR guidance with real-time operative monitoring of temperature will be available in the near future. If this technique will give better targeting and more uniform tissue destruction, its cost-effectiveness will have to be carefully evaluated. Finally, a recently reported synergistic effect between HIFU ablation and chemotherapy opens possibilities for treatment in high-risk or clinically advanced tumors.

  1. Hill crossing during preheating after hilltop inflation

    CERN Document Server

    Antusch, Stefan; Orani, Stefano

    2015-01-01

    In 'hilltop inflation', inflation takes place when the inflaton field slowly rolls from close to a maximum of its potential (i.e. the 'hilltop') towards its minimum. When the inflaton potential is associated with a phase transition, possible topological defects produced during this phase transition, such as domain walls, are efficiently diluted during inflation. It is typically assumed that they also do not reform after inflation, i.e. that the inflaton field stays on its side of the 'hill', finally performing damped oscillations around the minimum of the potential. In this paper we study the linear and the non-linear phases of preheating after hilltop inflation. We find that the fluctuations of the inflaton field during the tachyonic oscillation phase grow strong enough to allow the inflaton field to form regions in position space where it crosses 'over the top of the hill' towards the 'wrong vacuum'. We investigate the formation and behaviour of these overshooting regions using lattice simulations: Rather t...

  2. Application of the Separate Universe Approach to Preheating

    CERN Document Server

    Tanaka, T; Tanaka, Takahiro; Bassett, Bruce

    2003-01-01

    The dynamics of preheating after inflation has not been clearly understood yet.In particular, the issue of the generation of metric perturbations during preheating on super-horizon scale is still unsettled. Large scale perturbations may leave an imprint on the cosmic microwave background, or may become seeds for generation of primordial black holes. Hence, in order to make a connection between the particle physics models and cosmological observations, understanding the evolution of super-Hubble scale perturbations during preheating is important. Here, we propose an alternative treatment to handle this issue based on the so-called separate universe approach, which suggests less efficient amplification of super-Hubble modes during preheating than was expected before. We also point out an important issue which may have been overlooked in previous treatments.

  3. Equation of state and Beginning of Thermalization After Preheating

    CERN Document Server

    Podolsky, D I; Kofman, L; Peloso, M; Podolsky, Dmitry I.; Felder, Gary N.; Kofman, Lev; Peloso, Marco

    2006-01-01

    We study the out-of-equilibrium nonlinear dynamics of fields after post-inflationary preheating. During preheating, the energy in the homogeneous inflaton is exponentially rapidly transfered into highly occupied out-of-equilibrium inhomogeneous modes, which subsequently evolve towards equilibrium. The infrared modes excited during preheating evolve towards a saturated distribution long before thermalization completes. We compute the equation of state during and immediately after preheating. It rapidly evolves towards radiation domination long before the actual thermal equilibrium is established. The exact time of this transition is a non-monotonic function of the coupling between the inflaton and the decay products, and it varies only very weakly (around 10^(-35) s) as this coupling changes over several orders of magnitude. This result is applied to refine the relation between the number of efoldings N and the physical wavelength of perturbations generated during inflation. We also discuss the implications fo...

  4. Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids

    Directory of Open Access Journals (Sweden)

    Gaurav A Garg

    2011-01-01

    Full Text Available Abstract : Keloid is a difficult-to-treat condition and an ideal treatment modality is not available. Carbon dioxide (CO 2 laser is one of the modalities to treat keloids. Aim : To evaluate the effect of CO 2 laser ablation followed by intralesional steroids on keloids. Settings and Design : This was a prospective, single-center, uncontrolled, open study. Materials and Methods : Twenty-eight patients having 35 keloids were included in the study. Keloids were ablated or excised with CO 2 laser followed by intralesional steroid 3-4 weeks apart for 6 months. Results were evaluated after 6 months of stopping of intralesional steroids. Statistical Analysis : Fisher′s exact test was applied for obtaining difference in recurrence rate of regular and irregular patients. Results : Thirteen patients followed up regularly for intralesional steroids. During 6 months of follow-up after stoppage of steroids, only two patients showed recurrence. Ten patients were irregular for intralesional steroids and seven of them showed recurrence. Difference in recurrence rate of regular and irregular patients was significant. Conclusion : Only CO 2 laser ablation is not sufficient for halting the pathogenesis of keloid formation.We therefore conclude that CO 2 laser followed by intralesional steroid is a useful therapeutic approach for the treatment of keloids; however, patients need to be observed for recurrence over the next 1 year.

  5. Effects of Nonequilibrium Chemistry and Darcy-Forchheimer Pyrolysis Flow for Charring Ablator

    Science.gov (United States)

    Chen, Yih-Kanq; Milos, Frank S.

    2013-01-01

    The fully implicit ablation and thermal response code simulates pyrolysis and ablation of thermal protection materials and systems. The governing equations, which include energy conservation, a three-component decomposition model, and a surface energy balance, are solved with a moving grid.This work describes new modeling capabilities that are added to a special version of code. These capabilities include a time-dependent pyrolysis gas flow momentum equation with Darcy-Forchheimer terms and pyrolysis gas species conservation equations with finite rate homogeneous chemical reactions. The total energy conservation equation is also enhanced for consistency with these new additions. Two groups of parametric studies of the phenolic impregnated carbon ablator are performed. In the first group, an Orion flight environment for a proposed lunar-return trajectory is considered. In the second group, various test conditions for arcjet models are examined. The central focus of these parametric studies is to understand the effect of pyrolysis gas momentum transfer on material in-depth thermal responses with finite-rate, equilibrium, or frozen homogeneous gas chemistry. Results indicate that the presence of chemical nonequilibrium pyrolysis gas flow does not significantly alter the in-depth thermal response performance predicted using the chemical equilibrium gas model.

  6. Heatshield Ablation Pattern Roughness Onset and Effects Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project will develop a practical method for predicting pattern roughness onset and quantitative effects on heat and mass transfer rates for heatshield materials...

  7. Catheter Ablation

    Science.gov (United States)

    ... ablation. Visit Cardiac ablation procedures and Cardiac conduction system for more information about this topic. Related ... National Institutes of Health Department of Health and Human Services USA.gov

  8. Gauge Field Preheating at the End of Inflation

    CERN Document Server

    Deskins, J Tate; Caldwell, Robert R

    2013-01-01

    Here we consider the possibility of preheating the Universe via the parametric amplification of a massless, U(1) abelian gauge field. We assume that the gauge field is coupled to the inflaton via a conformal factor with one free parameter. We present the results of high-resolution three-dimensional simulations of this model and show this mechanism efficiently preheats the Universe to a radiation-dominated final state.

  9. Pulsed erbium laser ablation of hard dental tissue: the effects of atomized water spray versus water surface film

    Science.gov (United States)

    Freiberg, Robert J.; Cozean, Colette D.

    2002-06-01

    It has been established that the ability of erbium lasers to ablate hard dental tissue is due primarily to the laser- initiated subsurface expansion of the interstitial water trapped within the enamel and that by maintaining a thin film of water on the surface of the tooth, the efficiency of the laser ablation is enhanced. It has recently been suggested that a more aggressive ablative mechanism, designated as a hydrokinetic effect, occurs when atomized water droplets, introduced between the erbium laser and the surface of the tooth, are accelerated in the laser's field and impact the tooth's surface. It is the objective of this study to determine if the proposed hydrokinetic effect exists and to establish its contribution to the dental hard tissue ablation process. Two commercially available dental laser systems were employed in the hard tissue ablation studies. One system employed a water irrigation system in which the water was applied directly to the tooth, forming a thin film of water on the tooth's surface. The other system employed pressurized air and water to create an atomized mist of water droplets between the laser hand piece and the tooth. The ablative properties of the two lasers were studied upon hard inorganic materials, which were void of any water content, as well as dental enamel, which contained interstitial water within its crystalline structure. In each case the erbium laser beam was moved across the surface of the target material at a constant velocity. When exposing material void of any water content, no ablation of the surfaces was observed with either laser system. In contrast, when the irrigated dental enamel was exposed to the laser radiation, a linear groove was formed in the enamel surface. The volume of ablated dental tissue associated with each irrigation method was measured and plotted as a function of the energy within the laser pulse. Both dental laser systems exhibited similar enamel ablation rates and comparable ablated surface

  10. Effect of Particle Concentration on Ablation Behavior of Carbon/Carbon Composites

    Directory of Open Access Journals (Sweden)

    ZHA Bai-lin

    2016-07-01

    Full Text Available A self-designed oxygen-kerosene ablation system was employed to study the ablation mechanism and performance of the carbon-carbon composites. Particle concentrations of the gas-solid two-phase ablation flow were 0, 1.37%, 2.22%, and 2.64% respectively. The microstructure of post-test samples was analysed through the scanning electron microscope (SEM, and the ablation rate was calculated. The influence principle of particle concentrations on the ablation rate of the carbon-carbon composites was studied, and the mechanism of ablation was analysed. Experiment results show that with no particles involved the mass ablation rate is 0.159g/s and the linear ablation rate is 0.175mm/s, while with particles introduced, the minimum mass ablation rate and linear ablation rate are 0.432g/s and 0.843mm/s respectively, with the increase of particle concentrations, the ablation rate becomes accelerated. Particle erosion makes the ablation of sample seriously intensified, and the ablation gradient of radial fiber on erosion surface is increased with the increase of particle concentrations as well.

  11. Effects of ablation energy and post-irradiation on the structure and properties of titanium dioxide nanomaterials

    Science.gov (United States)

    Guillén, G. García; Shaji, S.; Palma, M. I. Mendivil; Avellaneda, D.; Castillo, G. A.; Roy, T. K. Das; Gutiérrez, D. I. García; Krishnan, B.

    2017-05-01

    Nanomaterials of titanium oxide were prepared by pulsed laser ablation of a titanium metal target in distilled water. The ablation was performed at different laser energy (fluence) using a nanosecond pulsed Nd:YAG laser output of 1064 and 532 nm. A post-irradiation of titanium oxide nanocolloids obtained by ablation using 532 nm was carried out to explore its effects on the structure and properties. Analysis of morphology, crystalline phase, elemental composition, chemical state, optical and luminescent properties were performed using Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), X-Ray Photoelectron Spectroscopy (XPS), UV-vis absorption spectroscopy and room temperature photoluminescence spectroscopy. It was found that titanium oxide nanomaterial morphologies and optical properties were determined by ablation wavelength and fluence. Further, nanocolloids prepared by 532 nm ablation showed a crystalline phase change by laser post-irradiation. The results showed that pulsed laser ablation in liquid as well as post-irradiation were effective in modifying the final structure and properties of titanium oxide nanocolloids.

  12. Effects of femtosecond laser ablation on the surface morphology and microstructure of a bulk TiCuPdZr glass alloy

    Institute of Scientific and Technical Information of China (English)

    WANG Hongshui; LIANG Chunyong; CHEN Xueguang; WANG Lei; YANG Yang; YANG Jianjun; ZHU Shengli; LI Changyi

    2009-01-01

    The effects of femtosecond laser ablation on the surface characteristics and microstructure of a bulk TiCuPdZr glass alloy were investigated. The heat influence zone of femtosecond laser ablated with a laser energy of 100 μJ exhibits a ripple-like feather, while a porous structure appears on the surface of the specimen ablated by a 200 μJ femtosecond laser. The contents of Ti, Zr, and Pd on the ablated surface decrease and that of Cu increases with increasing laser energy. The crystallization process occurs on the glass alloy specimens during femtosecond laser ablation, and the crystallinity of a 100 μJ femtosecond laser-ablated specimen is greater than that of a 200 μJ femtosecond laser-ablated one.

  13. Preheating after multifield inflation with nonminimal couplings, III: Dynamical spacetime results

    CERN Document Server

    DeCross, Matthew P; Prabhu, Anirudh; Prescod-Weinstein, Chanda; Sfakianakis, Evangelos I

    2016-01-01

    This paper concludes our semi-analytic study of preheating in inflationary models comprised of multiple scalar fields coupled nonminimally to gravity. Using the covariant framework of Ref. [1], we extend the rigid-spacetime results of Ref. [2] by considering both the expansion of the universe during preheating, as well as the effect of the coupled metric perturbations on particle production. The adiabatic and isocurvature perturbations are governed by different effective masses that scale differently with the nonminimal couplings and evolve differently in time. The effective mass for the adiabatic modes is dominated by contributions from the coupled metric perturbations immediately after inflation. The metric perturbations contribute an oscillating tachyonic term that enhances an early period of significant particle production for the adiabatic modes, which ceases on a time-scale governed by the nonminimal couplings $\\xi_I$. The effective mass of the isocurvature perturbations, on the other hand, is dominated...

  14. Laser wavelength effect on nanosecond laser light reflection in ablation of metals

    Science.gov (United States)

    Benavides, O.; de la Cruz May, L.; Mejia, E. B.; Ruz Hernandez, J. A.; Flores Gil, A.

    2016-12-01

    Reflection of nanosecond laser pulses with different wavelengths (1.06 and 0.69 µm) in ablation of titanium in air is studied experimentally. The laser wavelength effect on reflection is essential at low laser fluence values. However, it becomes negligible for laser fluence values by about an order of magnitude higher than the plasma ignition threshold. We speculate that the disappearance of the wavelength effect is explained by counter-acting processes of the laser light absorption in plasma, which increases with laser wavelength, and absorption in the surface layer, which decreases with increasing laser wavelength.

  15. The Effects of the Factors Related to the Patient and the Disease on the Performance of Ablation Therapy in Patients with Differentiated Thyroid Cancer who have Received I-131 Ablation Therapy

    Directory of Open Access Journals (Sweden)

    Tarık Şengöz

    2012-12-01

    Full Text Available Objective: To investigate whether the factors related to the patient and the disease have any effect on the success of ablation therapy in patients with differentiated thyroid cancer who have received I-131 ablation therapy. Material and Methods: All the patients with differentiated thyroid cancer were referred for I-131 ablation therapy after thyroidectomy between July 2007 and September 2009. The patients had at least six months of follow-up. Age, gender, type of tumor, presence of capsule invasion, size of tumor, number of the tumors, localization of the tumor, invasion of thyroid capsule, lymph/vessel invasion, presence of metastatic lymph nodes, type of surgery, preablation values of thyroglobulin (Tg, AntiTg, TSH, surveys for the evaluation of metastatic disease, (thyroid and bone scintigraphy, neck and abdominal ultrasonography, chest and brain computerized tomography, administered dose, postablation I-131 whole body scan (WBS and diagnostic I-131 WBS, neck USG, values of Tg and AntiTg at the 6th month were recorded. The presence of residual thyroid activity on the 6th month diagnostic I-131 WBS image was accepted as the criterion for ablation success. Results: 191 patients with differentiated thyroid cancer were assessed in this study. The overall success rate of the first ablation therapy was 74.3%. The success rate of the ablation therapy was 66% and 75% in metastatic group and non-metastatic group, respectively. Except the significant correlation between the number of pathologic lymph nodes and the success of ablation (p=0.025, there was no other significant correlation between the patient/disease related factors and the success of ablation therapy. Conclusion: Significant correlation between the number of the pathologic lymph nodes and the ablation therapy performance can also be due to statistical error because of the limited sample size. There was no significant correlation between other patient/disease related prognostic factors

  16. Renoprotective effects of telmisartan after unilateral renal ablation in rats

    Directory of Open Access Journals (Sweden)

    Matsuo T

    2013-10-01

    Full Text Available Tomohiro Matsuo, Yasuyoshi Miyata, Yuji Sagara, Yoshikazu Higami, Shohei Tobu, Manabu Matsuo, Mitsuru Noguchi, Isao Shimokawa, Hiroshi Kanetake, Hideki Sakai Department of Nephro-Urology, Department of Investigative Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Purpose: The renoprotective function of the angiotensin II type 1 receptor blocker (ARB is well-known in various studies, including the animal model of renal failure. However, detailed temporal changes of pathological and molecular findings after unilateral nephrectomy are not fully understood. The main purpose of this study was to clarify the renoprotective effects and pathological changes induced by the ARB in rat-remnant kidney (RK tissues after unilateral nephrectomy, but not after a 5/6 nephrectomy. Methods: Telmisartan, which is structurally and functionally unique among ARB, was used in this study. Three rat groups were examined: A no ARB administrated (RK, n=21; B continuous subcutaneous infusion of an ARB administrated (RK-ARB, n=21; and C a sham-operated group (Sham. Renal function was evaluated by blood urea nitrogen (BUN levels and creatinine clearance (Ccr. Fibrosis was evaluated by hydroxyproline levels and Masson's trichrome staining. Expressions of angiotensin II type 1 receptor (AT1R and transforming growth factor beta (TGF-ß were investigated by real-time polymerase chain reaction and Western blotting. Results: There was no significant difference regarding body and kidney weight or pathological features evaluated by hematoxylin and eosin staining between the RK and RK-ARB groups. The Ccr in the RK group was significantly lower than that in the Sham group (P<0.01, but no significant difference was found between the RK-ARB and Sham groups. The fibrotic area increased significantly with time after nephrectomy in the RK group. Although a similar trend was found in the RK-ARB group, the percentage of fibrous area in the RK-ARB group

  17. Transient Ablation of Teflon Hemispheres

    Science.gov (United States)

    Arai, Norio; Karashima, Kei-ichi; Sato, Kiyoshi

    1997-01-01

    For high-speed entry of space vehicles into atmospheric environments, ablation is a practical method for alleviating severe aerodynamic heating. Several studies have been undertaken on steady or quasi-steady ablation. However, ablation is a very complicated phenomenon in which a nonequilibrium chemical process is associated with an aerodynamic process that involves changes in body shape with time. Therefore, it seems realistic to consider that ablation is an unsteady phenomenon. In the design of an ablative heat-shield system, since the ultimate purpose of the heat shield is to keep the internal temperature of the space vehicle at a safe level during entry, the transient heat conduction characteristics of the ablator may be critical in the selection of the material and its thickness. This note presents an experimental study of transient ablation of Teflon, with particular emphasis on the change in body shape, the instantaneous internal temperature distribution, and the effect of thermal expansion on ablation rate.

  18. Waste Heat Recovery by Heat Pipe Air-Preheater to Energy Thrift from the Furnace in a Hot Forging Process

    Directory of Open Access Journals (Sweden)

    Lerchai Yodrak

    2010-01-01

    Full Text Available Problem statement: Currently, the heat pipe air-preheater has become importance equipment for energy recovery from industrial waste heat because of its low investment cost and high thermal conductivity. Approach: This purpose of the study was to design, construct and test the waste heat recovery by heat pipe air-preheater from the furnace in a hot brass forging process. The mathematical model was developed to predict heat transfer rate and applied to compute the heat pipe air-preheater in a hot brass forging process. The heat pipe air-preheater was designed, constructed and tested under medium temperature operating conditions with inlet hot gas ranging between 370-420°C using water as the working fluid with 50% filling by volume of evaporator length. Results: The experiment findings indicated that when the hot gas temperature increased, the heat transfer rate also increased. If the internal diameter increased, the heat transfer rate increased and when the tube arrangement changed from inline to staggered arrangement, the heat transfer rate increased. Conclusion/Recommendations: The heat pipe air-preheater can reduced the quantity of using gas in the furnace and achieve energy thrift effectively.

  19. Effect of High Z material on the performance of an air-breathing laser ablation thruster

    Science.gov (United States)

    Shimamura, Kohei; Kiyono, Inoru; Yokota, Ippei; Ozaki, Naoto; Yokota, Shigeru

    2016-09-01

    A Laser propulsion, such as a Lightcraft, is a candidate for the low cost transportation system between the ground to space instead of the chemical rocket. Using the shock wave induced by focusing laser beam on the ablator in air, the huge fuel is unnecessary to generate the thrust. In this study, the high-Z material was doped into the polystyrene to emphasize the ionization effect in air. We evaluate the intensity of the bremsstrahlung radiation, the plasma parameter, and the thrust performance.

  20. Acid skim milk gels: The gelation process as affected by preheated pH

    NARCIS (Netherlands)

    Lakemond, C.M.M.; Vliet, van T.

    2008-01-01

    The effect of preheating milk (10 min 80 [degree sign]C) at pH values from 6.20 to 6.90 on formation of acid skim milk gels was studied by dynamic oscillation measurements. Up to pH 6.65 a higher pH of heating (pHheating) resulted in a higher G'. Since below pH 4.9 the development of G'(pH)/G'(pH=4.

  1. Minimizing matrix effect by femtosecond laser ablation and ionization in elemental determination.

    Science.gov (United States)

    Zhang, Bochao; He, Miaohong; Hang, Wei; Huang, Benli

    2013-05-07

    Matrix effect is unavoidable in direct solid analysis, which usually is a leading cause of the nonstoichiometric effect in quantitative analysis. In this research, experiments were carried out to study the overall characteristics of atomization and ionization in laser-solid interaction. Both nanosecond (ns) and femtosecond (fs) lasers were applied in a buffer-gas-assisted ionization source coupled with an orthogonal time-of-flight mass spectrometer. Twenty-nine solid standards of ten different matrices, including six metals and four dielectrics, were analyzed. The results indicate that the fs-laser mode offers more stable relative sensitivity coefficients (RSCs) with irradiance higher than 7 × 10(13) W·cm(-2), which could be more reliable in the determination of element composition of solids. The matrix effect is reduced by half when the fs-laser is employed, owing to the fact that the fs-laser ablation and ionization (fs-LAI) incurs an almost heat-free ablation process and creates a dense plasma for the stable ionization.

  2. Investigation of Thermal Conductivity and Heat Characteristics of Oil Sands Using Ultrasound Irradiation for Shortening the Preheating Time

    Science.gov (United States)

    Kamagata, Shingo; Kawamura, Youhei; Okawa, Hirokazu; Mizutani, Koichi

    2012-07-01

    Oil sands are attractive as an energy resource. Bitumen, which is found in oil sands, has high viscosity, so that it does not flow. Most oil sands are underground and are developed with a method called steam-assisted gravity drainage (SAGD). Hot steam is injected underground to fluidize bitumen and promote its recovery. However, the preheating time is too long. One way of reducing running costs is by shortening the preheating time. Previous studies have found that bitumen can be extracted from oil sands efficiently by applying ultrasonic irradiation, but SAGD was not applied directly in these cases. Thus, the purpose of this study is to apply ultrasonic irradiation to SAGD, thereby shortening the preheating time of oil sands. As a model experiment for SAGD, heat transfer experiments in a sand layer made with Toyoura sand and silicone oil were conducted and the thermal effect with ultrasound was investigated.

  3. Simulation on temperature field of TIG welding of copper without preheating

    Institute of Scientific and Technical Information of China (English)

    LEI Yu-cheng; YU Wen-xia; LI Cai-hui; CHENG Xiao-nong

    2006-01-01

    According to the conservation of energy principle and technology characteristics of tungsten inert gas(TIG), a model of non-steady three-dimensional temperature field for red copper's TIG welding with a locomotive arc was established. The temperature field of welding pool was calculated with finite element software ANSYS. Indrafted the heat enthalpy conception and the surface distribution dual-ellipsoid model, the demands of welding numerical simulation was primely satisfied. Aimed at bad weldability of red copper, the TIG welding of thick-wall red copper was studied adopting Ar+N2 without preheating. The results show that the heating effect of arc is evidently enhanced, it is viable to achieve the no preheating TIG welding of red copper. Comparing the experimental values with the calculated ones under different technological parameters, the results indicate that the model and practical course are well matched, which proves that the model is reliable and correct.

  4. Operation of a cyclonic preheater in the Ca-looping for CO2 capture.

    Science.gov (United States)

    Martínez, Ana; Lara, Yolanda; Lisbona, Pilar; Romeo, Luis M

    2013-10-01

    Calcium looping is an emerging technology for CO2 capture that makes use of the calcium oxide as a sorbent. One of its main issues is the significant energy consumption in the calciner, where the regeneration of the sorbent takes place. Nevertheless, as a high temperature looping technology, the surplus heat flows may be used to reduce the energy needs in this reactor. The addition of a cyclonic preheater similar to those used in the cement industry is proposed in this work. A calcium looping system was modeled and simulated to assess the advantages and disadvantages of the inclusion of a cyclonic preheater. Despite the negative effect on the maximum average capture capacity of the sorbent, a reduction on the coal and oxygen consumptions and on the extra CO2 generated in the calciner is obtained.

  5. Heating of Intracluster Gas by Jet Activities of AGN Is the "Preheating" Scenario Realistic?

    CERN Document Server

    Yamada, M; Yamada, Masako; Fujita, Yutaka

    2001-01-01

    We investigate the non-gravitational heating of hot gas in clusters of galaxies (intracluster medium; ICM) on the assumption that the gas is heated well before cluster formation ('preheating'). We examine the jet activities of radio galaxies as the sources of excess energy in ICM, and the deformation of the cosmic microwave background (the Sunyaev-Zel'dovich effect) by hot electrons produced at the jet terminal shocks. We show that the observed excess entropy of ICM and {\\sl COBE/FIRAS} upper limit for the Compton $y$-parameter are compatible with each other only when the heating by the jets occurred at relatively small redshift ($z\\lesssim 3$). Since this result contradicts the assumption of 'preheating', it suggests that the heating occurred simultaneously with or after cluster formation.

  6. The Cluster Gas Mass - Temperature Relation Evidence for a High Level of Preheating

    CERN Document Server

    McCarthy, I G; Balogh, M L; Carthy, Ian G. Mc; Babul, Arif; Balogh, Michael L.

    2002-01-01

    Recent X-ray observations have been used to demonstrate that the cluster gas mass - temperature relation is steeper than theoretical self-similar predictions drawn from numerical simulations that consider the evolution of the cluster gas through the effects of gravity and shock heating alone. One possible explanation for this is that the gas mass fraction is not constant across clusters of different temperature, as usually assumed. Observationally, however, there is no compelling evidence for gas mass fraction variation, especially in the case of hot clusters. Seeking an alternative physical explanation for the observed trends, we investigate the role of preheating the intracluster medium by some arbitrary source on the cluster gas mass - temperature relation for clusters with emission-weighted mean temperatures of greater than about 3 keV. Making use of the physically-motivated, analytic model developed by Babul et al. (2002), we find that preheating does, indeed, lead to a steeper relation. This is in agree...

  7. Imaging the ultrafast Kerr effect, free carrier generation, relaxation and ablation dynamics of Lithium Niobate irradiated with femtosecond laser pulses

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Lechuga, Mario, E-mail: mario@io.cfmac.csic.es; Siegel, Jan, E-mail: j.siegel@io.cfmac.csic.es; Hernandez-Rueda, Javier; Solis, Javier [Laser Processing Group, Instituto de Optica, CSIC, Serrano 121, 28006 Madrid (Spain)

    2014-09-21

    The interaction of high-power single 130 femtosecond (fs) laser pulses with the surface of Lithium Niobate is experimentally investigated in this work. The use of fs-resolution time-resolved microscopy allows us to separately observe the instantaneous optical Kerr effect induced by the pulse and the generation of a free electron plasma. The maximum electron density is reached 550 fs after the peak of the Kerr effect, confirming the presence of a delayed carrier generation mechanism. We have also observed the appearance of transient Newton rings during the ablation process, related to optical interference of the probe beam reflected at the front and back surface of the ablating layer. Finally, we have analyzed the dynamics of the photorefractive effect on a much longer time scale by measuring the evolution of the transmittance of the irradiated area for different fluences below the ablation threshold.

  8. Radiofrequency ablation in dermatology

    Directory of Open Access Journals (Sweden)

    Sachdeva Silonie

    2007-01-01

    Full Text Available Radiofreqeuency ablation is a versatile dermatosurgical procedure used for surgical management of skin lesions by using various forms of alternating current at an ultra high frequency. The major modalities in radiofrequency are electrosection, electrocoagulation, electrodessication and fulguration. The use of radiofrequency ablation in dermatosurgical practice has gained importance in recent years as it can be used to treat most of the skin lesions with ease in less time with clean surgical field due to adequate hemostasis and with minimal side effects and complications. This article focuses on the major tissue effects and factors influencing radiofrequency ablation and its application for various dermatological conditions.

  9. Effective dose analysis of three-dimensional rotational angiography during catheter ablation procedures

    Science.gov (United States)

    Wielandts, J.-Y.; Smans, K.; Ector, J.; De Buck, S.; Heidbüchel, H.; Bosmans, H.

    2010-02-01

    There is increasing use of three-dimensional rotational angiography (3DRA) during cardiac ablation procedures. As compared with 2D angiography, a large series of images are acquired, creating the potential for high radiation doses. The aim of the present study was to quantify patient-specific effective doses. In this study, we developed a computer model to accurately calculate organ doses and the effective dose incurred during 3DRA image acquisition. The computer model simulates the exposure geometry and uses the actual exposure parameters, including the variation in tube voltage and current that is realized through the automatic exposure control (AEC). We performed 3DRA dose calculations in 42 patients referred for ablation on the Siemens Axiom Artis DynaCT system (Erlangen, Germany). Organ doses and effective dose were calculated separately for all projections in the course of the C-arm rotation. The influence of patient body mass index (BMI), dose-area product (DAP), collimation and dose per frame (DPF) rate setting on the calculated doses was also analysed. The effective dose was found to be 5.5 ± 1.4 mSv according to ICRP 60 and 6.6 ± 1.8 mSv according to ICRP 103. Effective dose showed an inversely proportional relationship to BMI, while DAP was nearly BMI independent. No simple conversion coefficient between DAP and effective dose could be derived. DPF reduction did not result in a proportional effective dose decrease. These paradoxical findings were explained by the settings of the AEC and the limitations of the x-ray tube. Collimation reduced the effective dose by more than 20%. Three-dimensional rotational angiography is associated with a definite but acceptable radiation dose that can be calculated for all patients separately. Their BMI is a predictor of the effective dose. The dose reduction achieved with collimation suggests that its use is imperative during the 3DRA procedure.

  10. Effective dose analysis of three-dimensional rotational angiography during catheter ablation procedures

    Energy Technology Data Exchange (ETDEWEB)

    Wielandts, J-Y; Ector, J; De Buck, S; Heidbuechel, H [Department of Electrophysiology-Cardiology, University Hospital Gasthuisberg, 49, Herestraat, 3000-Leuven (Belgium); Smans, K [Belgian Nuclear Research Centre (SCK-CEN), Radiation Protection, Dosimetry and Calibration, Boeretang, 2400-Mol (Belgium); Bosmans, H [Department of Radiology, University Hospital Gasthuisberg, 49, Herestraat, 3000-Leuven (Belgium)], E-mail: jean-yves.wielandts@uz.kuleuven.ac.be

    2010-02-07

    There is increasing use of three-dimensional rotational angiography (3DRA) during cardiac ablation procedures. As compared with 2D angiography, a large series of images are acquired, creating the potential for high radiation doses. The aim of the present study was to quantify patient-specific effective doses. In this study, we developed a computer model to accurately calculate organ doses and the effective dose incurred during 3DRA image acquisition. The computer model simulates the exposure geometry and uses the actual exposure parameters, including the variation in tube voltage and current that is realized through the automatic exposure control (AEC). We performed 3DRA dose calculations in 42 patients referred for ablation on the Siemens Axiom Artis DynaCT system (Erlangen, Germany). Organ doses and effective dose were calculated separately for all projections in the course of the C-arm rotation. The influence of patient body mass index (BMI), dose-area product (DAP), collimation and dose per frame (DPF) rate setting on the calculated doses was also analysed. The effective dose was found to be 5.5 {+-} 1.4 mSv according to ICRP 60 and 6.6 {+-} 1.8 mSv according to ICRP 103. Effective dose showed an inversely proportional relationship to BMI, while DAP was nearly BMI independent. No simple conversion coefficient between DAP and effective dose could be derived. DPF reduction did not result in a proportional effective dose decrease. These paradoxical findings were explained by the settings of the AEC and the limitations of the x-ray tube. Collimation reduced the effective dose by more than 20%. Three-dimensional rotational angiography is associated with a definite but acceptable radiation dose that can be calculated for all patients separately. Their BMI is a predictor of the effective dose. The dose reduction achieved with collimation suggests that its use is imperative during the 3DRA procedure.

  11. The effect of radiofrequency ablation on different organs: Ex vivo and in vivo comparative studies

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoo Na [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of); Rhim, Hyunchul, E-mail: rhimhc@skku.edu [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of); Choi, Dongil; Kim, Young-sun; Lee, Min Woo; Chang, Ilsoo; Lee, Won Jae; Lim, Hyo K. [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-Ku, Seoul 135-710 (Korea, Republic of)

    2011-11-15

    Objective: The purposes of this study are to evaluate the ex vivo and in vivo efficacy of radiofrequency ablation (RFA) on different porcine tissues by the ablation of three different sites simultaneously. Materials and methods: A multichannel RFA system, enables three separate tumors to be ablated simultaneously, was used. RFA procedures were applied to normal porcine liver, kidney, and muscle together ex vivo (n = 12) and in vivo (n = 17). Pre-impedances, defined as baseline systemic impedances of tissues before beginning RFA, and the areas of ablation zones were measured and compared. Results: The areas of ablation zones among three organs had a significant difference in decreasing order as follows: liver, muscle, and kidney in the ex vivo study (p = 0.001); muscle, liver, and kidney in the in vivo study (p < 0.0001). The areas of ablation zones between ex vivo and in vivo had a significant difference in the liver and muscle (each p < 0.05). There was no significant correlation between the areas of ablation zones and pre-impedances in both studies. Conclusions: Renal RFA produced the smallest ablation zone in both in vivo and ex vivo studies. Muscular RFA demonstrated the largest ablation zone in the in vivo study, and hepatic RFA showed the largest ablation zone in the ex vivo study. This variability in the tissues should be considered for performing an optimized RFA for each organ site.

  12. Experimental study on preheated combustion of pulverized semi-coke

    Science.gov (United States)

    Yao, Yao; Zhu, Jianguo; Lu, Qinggang; Zhou, Zuxu

    2015-06-01

    In a test rig, pulverized semi-coke was preheated to 850oC in a circulating fluidized bed (CFB) and then combusted at 1100oC in a down-fired combustor (DFC). Experiments were conducted to reveal the effects of three secondary air nozzle cases (co-axial jet, top circular jet and wall circular jet) on the NO emission. The results show that the optimized secondary air nozzle can reduce NO emission. O2 concentration profile is the major factor affecting NO generation and emission, which is led by the secondary air nozzle. The lower O2 concentration led to the generation of lower initial NO. The NO emission at the exit of the DFC was reduced from 189 to 92 mg/m3 (@ 6% O2) with the decrease of initial generation. The peak of NO at 100 mm below the nozzle should be attributed to the oxidization of NH3 in the syngas, rather than the oxidization of fuel-N in the char. The low and well-distributed O2 concentration contributes to the reduction of initial NO, which helps to reduce the NO emission. The combustion efficiencies of the cases of the co-axial jet, the top circular jet, and the wall circular jet are 97.88%, 98.94% and 98.74%, respectively.

  13. Gravity Waves from Tachyonic Preheating after Hybrid Inflation

    CERN Document Server

    Dufaux, Jean Francois; Kofman, Lev; Navros, Olga

    2008-01-01

    We study the stochastic background of gravitational waves produced from preheating in hybrid inflation models. We investigate different dynamical regimes of preheating in these models and we compute the resulting gravity wave spectra using analytical estimates and numerical simulations. We discuss the dependence of the gravity wave frequencies and amplitudes on the various potential parameters. We find that large regions of the parameter space leads to gravity waves that may be observable in upcoming interferometric experiments, including Advanced LIGO, but this generally requires very small coupling constants.

  14. Formation of sub-horizon black holes from preheating

    CERN Document Server

    Torres-Lomas, E; Malik, Karim A; Ureña-López, L Arturo

    2014-01-01

    We study the production of primordial black holes (PBHs) during the preheating stage that follows a chaotic inflationary phase. The scalar fields present in the process are evolved numerically using a modified version of the HLATTICE code. From the output of the numerical simulation we compute the probability distribution of curvature fluctuations paying particular attention to sub-horizon scales. We find that in some specific models these modes grow to large amplitudes developing highly non-Gaussian probability distributions. We then calculate PBH abundances using the standard Press-Schechter criterion and find that overproduction of PBHs is likely in some regions of the chaotic preheating parameter-space.

  15. Investigation of effect of solenoid magnet on emittances of ion beam from laser ablation plasma

    Energy Technology Data Exchange (ETDEWEB)

    Ikeda, Shunsuke, E-mail: shunsuke.ikeda@riken.jp; Sekine, Megumi [Tokyo Institute of Technology, Yokohama, Kanagawa (Japan); Riken, Wako, Saitama (Japan); Romanelli, Mark [Cornell University, Ithaca, New York 14850 (United States); Cinquegrani, David [University of Michigan, Ann Arbor, Michigan 48109 (United States); Kumaki, Masafumi [Waseda University, Shinjuku, Tokyo (Japan); Fuwa, Yasuhiro [Kyoto University, Uji, Kyoto (Japan); Kanesue, Takeshi; Okamura, Masahiro [Brookhaven National Laboratory, Upton, New York 11973 (United States); Horioka, Kazuhiko [Tokyo Institute of Technology, Yokohama, Kanagawa (Japan)

    2014-02-15

    A magnetic field can increase an ion current of a laser ablation plasma and is expected to control the change of the plasma ion current. However, the magnetic field can also make some fluctuations of the plasma and the effect on the beam emittance and the emission surface is not clear. To investigate the effect of a magnetic field, we extracted the ion beams under three conditions where without magnetic field, with magnetic field, and without magnetic field with higher laser energy to measure the beam distribution in phase space. Then we compared the relations between the plasma ion current density into the extraction gap and the Twiss parameters with each condition. We observed the effect of the magnetic field on the emission surface.

  16. Investigation of effect of solenoid magnet on emittances of ion beam from laser ablation plasma

    Science.gov (United States)

    Ikeda, Shunsuke; Romanelli, Mark; Cinquegrani, David; Sekine, Megumi; Kumaki, Masafumi; Fuwa, Yasuhiro; Kanesue, Takeshi; Okamura, Masahiro; Horioka, Kazuhiko

    2014-02-01

    A magnetic field can increase an ion current of a laser ablation plasma and is expected to control the change of the plasma ion current. However, the magnetic field can also make some fluctuations of the plasma and the effect on the beam emittance and the emission surface is not clear. To investigate the effect of a magnetic field, we extracted the ion beams under three conditions where without magnetic field, with magnetic field, and without magnetic field with higher laser energy to measure the beam distribution in phase space. Then we compared the relations between the plasma ion current density into the extraction gap and the Twiss parameters with each condition. We observed the effect of the magnetic field on the emission surface.

  17. Fiscal 1996 project on the modeling for effective energy consumption in developing countries under a consignment from NEDO. Recent on the results of the demonstrative study on scrap preheater of electric furnace in the iron making process (for public); 1996 nendo hatten tojokoku energy shohi koritsuka model jigyo Shin Energy Sangyo Gijutsu Sogo Kaihatsu Kiko itaku. Seitetsu katei ni okeru denkiro no genryo yonetsu sochi ni kakawaru jissho kenkyu seika hokokusho (kokaiyo)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Indonesia is the biggest iron steel producing country in the ASEAN countries. Most of the production is produced by the electric furnace method in which iron steel scrap is used as a material. However, an energy saving measure in this method, the electric furnace scrap preheater using flue gas, has not yet been spread on a full scale. This R and D is aimed at developing jointly with Indonesia an electric furnace scrap preheater for medium/small size electric furnaces which are adoptable to the present iron making situation in Indonesia and installing it to the electric furnace of the iron making plant in Indonesia for a demonstrative study on energy saving, etc. Spread/expansion of the electric furnace scrap preheater which is an excellent energy saving system targeted expansion of energy saving technology not only of Indonesia, but of ASEAN countries and Japan. In this fiscal year, remodeling of part of the system was made by change of flue gas flow for increasing the energy saving effect, and at the same time, a research study was made of a scrap reheater effective as a total system. Moreover, the paper investigated technical data/information in Japan and overseas. 3 figs., 9 tabs.

  18. Laser ablation in a running hall effect thruster for space propulsion

    Science.gov (United States)

    Balika, L.; Focsa, C.; Gurlui, S.; Pellerin, S.; Pellerin, N.; Pagnon, D.; Dudeck, M.

    2013-07-01

    Hall Effect Thrusters (HETs) are promising electric propulsion devices for the station-keeping of geostationary satellites (more than 120 in orbit to date). Moreover, they can offer a cost-effective solution for interplanetary journey, as proved by the recent ESA SMART-1 mission to the Moon. The main limiting factor of the HETs lifetime is the erosion of the annular channel ceramics walls. In order to provide a better understanding of the energy deposition on the insulated walls, a laser irradiation study has been carried out on a PPS100-ML thruster during its run in the PIVOINE-2G ground test facility (CNRS Orléans, France). Two distinct approaches have been followed: continuous wave fiber laser irradiation (generation of thermal defects) and nanosecond pulsed laser ablation (generation of topological defects). The irradiated zones have been monitored in situ by IR thermography and optical emission spectroscopy and further investigated ex situ by scanning electron microscopy and profilometry.

  19. Effectiveness of various thermal ablation techniques for the treatment of nodular thyroid disease--comparison of laser-induced thermotherapy and bipolar radiofrequency ablation.

    Science.gov (United States)

    Ritz, Jörg-Peter; Lehmann, Kai S; Schumann, Thomas; Knappe, Verena; Zurbuchen, Urte; Buhr, Heinz J; Holmer, Christoph

    2011-07-01

    Alternative minimally invasive treatment options such as radiofrequency ablation (RFA) or laser-induced thermotherapy (LITT) are at present under investigation for achieving a nonsurgical targeted cytoreduction in benign and malignant thyroid lesions. So far, studies have not been able to show a secure advantage for neither LITT nor RFA. The aim of this study was to compare the two ablation procedures in terms of their effectiveness. Thermal lesions were induced in porcine thyroid glands either by LITT or bipolar RFA ex vivo (n = 110 each) and in vivo (n = 10 each) using power settings between 10 and 20 W. Temperature spread during application was documented in 5- and 10-mm distance of the applicator. Postinterventional lesion diameters were measured and lesion size was calculated. Furthermore, enzyme histochemical analysis of the thyroid tissue was performed in vivo. Lesion volumes induced by LITT ranged between 0.74 ± 0.18 cm(3) (10 W) and 3.80 ± 0.41 cm(3) (20 W) with a maximum of 5.13 ± 0.16 cm(3) at 18 W. The inducible lesion volumes by RFA were between 2.43 ± 0.68 cm(3) (10 W) and 0.91 ± 0.71 cm(3) (20 W) with a maximum of 2.80 ± 0.85 cm(3) at 14 W. The maximum temperatures were 112.9 ± 9.2°C (LITT) and 61.6 ± 13.9°C (RFA) at a distance of 5 mm and 73.2 ± 6.7°C (LITT) and 53.5 ± 8.6°C (RFA) at a distance of 10 mm. The histochemical analysis demonstrates a complete loss of NADPH dehydrogenase activity in thermal lesions as a sign of irreversible cell damage both for LITT and RFA. This study is the first to compare the effectiveness of laser-induced thermotherapy and radiofrequency ablation of thyroid tissue. LITT as well as RFA are suitable for singular thyroid nodules and induces reproducible clinically relevant lesions in an appropriate application time. The maximum inducible lesion volumes by LITT are significantly larger than by RFA with the devices used herein.

  20. Effect of variable heat transfer coefficient on tissue temperature next to a large vessel during radiofrequency tumor ablation

    Directory of Open Access Journals (Sweden)

    Pinheiro Cleber

    2008-07-01

    Full Text Available Abstract Background One of the current shortcomings of radiofrequency (RF tumor ablation is its limited performance in regions close to large blood vessels, resulting in high recurrence rates at these locations. Computer models have been used to determine tissue temperatures during tumor ablation procedures. To simulate large vessels, either constant wall temperature or constant convective heat transfer coefficient (h have been assumed at the vessel surface to simulate convection. However, the actual distribution of the temperature on the vessel wall is non-uniform and time-varying, and this feature makes the convective coefficient variable. Methods This paper presents a realistic time-varying model in which h is a function of the temperature distribution at the vessel wall. The finite-element method (FEM was employed in order to model RF hepatic ablation. Two geometrical configurations were investigated. The RF electrode was placed at distances of 1 and 5 mm from a large vessel (10 mm diameter. Results When the ablation procedure takes longer than 1–2 min, the attained coagulation zone obtained with both time-varying h and constant h does not differ significantly. However, for short duration ablation (5–10 s and when the electrode is 1 mm away from the vessel, the use of constant h can lead to errors as high as 20% in the estimation of the coagulation zone. Conclusion For tumor ablation procedures typically lasting at least 5 min, this study shows that modeling the heat sink effect of large vessels by applying constant h as a boundary condition will yield precise results while reducing computational complexity. However, for other thermal therapies with shorter treatment using a time-varying h may be necessary.

  1. Magnetic thermal ablation using ferrofluids: influence of administration mode on biological effect in different porcine tissues.

    Science.gov (United States)

    Bruners, Philipp; Hodenius, Michael; Baumann, Martin; Oversohl, Jessica; Günther, Rolf W; Schmitz-Rode, Thomas; Mahnken, Andreas H

    2008-01-01

    The purpose of this study was to compare the effects of magnetic thermal ablation in different porcine tissues using either a singular injection or a continuous infusion of superparamagnetic iron oxide nanoparticles. In the first setting samples of three ferrofluids containing different amounts of iron (1:171, 2:192, and 3:214 mg/ml) were singularly interstitially injected into specimens of porcine liver, kidney, and muscle (n = 5). Then the specimens were exposed to an alternating magnetic field (2.86 kA/m, 190 kHz) generated by a circular coil for 5 min. In the second experimental setup ferrofluid samples were continuously interstitially infused into the tissue specimens during the exposure to the magnetic field. To measure the temperature increase two fiber-optic temperature probes with a fixed distance of 0.5 cm were inserted into the specimens along the puncture tract of the injection needle and the temperature was measured every 15 s. Finally, the specimens were dissected, the diameters of the created thermal lesions were measured, and the volumes were calculated and compared. Compared to continuous infusion, a single injection of ferrofluids resulted in smaller coagulation volumes in all tissues. Significant differences regarding coagulation volume were found in kidney and muscle specimens. The continuous infusion technique led to more elliptically shaped coagulation volumes due to larger diameters along the puncture tract. Our data show the feasibility of magnetic thermal ablation using either a single interstitial injection or continuous infusion for therapy of lesions in muscle, kidney, and liver. Continuous infusion of ferrofluids results in larger zones of necrosis compared to a single injection technique.

  2. Evaluation of the effective corneal ablation in refractive surgery by two 3D topographic surface matching methods

    Science.gov (United States)

    Bueeler, M.; Donitzky, Ch.; Mrochen, M.

    2006-02-01

    The effectiveness of the corneal ablation process in refractive surgery is mostly evaluated by indirect measures of vision or optical quality such as post-operative refraction or wavefront aberrometry. Yet, the effective amount of corneal tissue removed in the treatment can only be determined by correctly overlapping a pre- and a post-operative topography measurement. However such an overlap is not trivial due to the discrepancy in the centration axes used in the measurement and the treatment, as well as due to the shift of ocular axes through the treatment or tilt between the two surfaces. We therefore present two methods for overlapping pre- and post-operative topographies for the purpose of extracting an effective corneal ablation profile. Method one uses a 3-dimensional profile matching algorithm and cross-correlation analysis on surface rings outside the optical zone of the topographies. Method two employs a surface normal matching routine to align the two surfaces along their common ablation axis. The profile matching method implies the problem that it requires measurement data outside of the optical zone which was found to be uncertain with placido-disk-based topographers. Method number two is more simple and implies the advantage of using measurement data within the optical zone. For regular profiles the extracted ablation profiles showed a very good match with the planned ones. Surprisingly, even for highly irregular profiles of topography-guided laser treatments the method delivered reasonable overlaps when being compared to the planned profiles. Analysis of the effective tissue removal yields valuable information on the quality of the ablation process.

  3. Effects of sex on the incidence of cardiac tamponade after catheter ablation of atrial fibrillation: results from a worldwide survey in 34 943 atrial fibrillation ablation procedures.

    Science.gov (United States)

    Michowitz, Yoav; Rahkovich, Michael; Oral, Hakan; Zado, Erica S; Tilz, Roland; John, Silke; Denis, Arnaud; Di Biase, Luigi; Winkle, Roger A; Mikhaylov, Evgeny N; Ruskin, Jeremy N; Yao, Yan; Josephson, Mark E; Tanner, Hildegard; Miller, John M; Champagne, Jean; Della Bella, Paolo; Kumagai, Koichiro; Defaye, Pascal; Luria, David; Lebedev, Dmitry S; Natale, Andrea; Jais, Pierre; Hindricks, Gerhard; Kuck, Karl-Heinz; Marchlinski, Francis E; Morady, Fred; Belhassen, Bernard

    2014-04-01

    Cardiac tamponade is the most dramatic complication observed during atrial fibrillation (AF) ablation and the leading cause of procedure-related mortality. Female sex is a known risk factor for complications during AF ablation; however, it is unknown whether women have a higher risk of tamponade. A systematic Medline search was used to locate academic electrophysiological centers that reported cases of tamponade occurring during AF ablation. Centers were asked to provide information on cases of acute tamponade according to sex and their mode of management including any case of related mortality. Nineteen electrophysiological centers provided information on 34 943 ablation procedures involving 25 261 (72%) men. Overall, 289 (0.9%) cases of tamponade were reported: 120 (1.24%) in women and 169 (0.67%) in men (odds ratio, 1.83; Ptamponade with substantially lower risk in high-volume centers. Most cases of tamponade occurred during catheter manipulation or ablation; women tended to develop more tamponades during transseptal catheterization. No sex difference in the mode of management was observed. However, 16% cases of tamponade required surgery with lower rates in high-volume centers. Three cases of tamponade (1%) culminated in death. Tamponade during AF ablation procedures is relatively rare. Women have an ≈2-fold higher risk for developing this complication. The risk of tamponade among women decreases substantially in high-volume centers. Surgical backup and acute management skills for treating tamponade are important in centers performing AF ablation.

  4. Effect of nanosecond pulse laser ablation on the surface morphology of Zr-based metallic glass

    Science.gov (United States)

    Zhu, Yunhu; Fu, Jie; Zheng, Chao; Ji, Zhong

    2016-09-01

    In this study, we investigated the ripple patterns formation on the surface of Zr41.2Ti13.8Cu12.5Ni10Be22.5 (vit1) bulk metallic glass using a nanosecond pulse laser ablation in air with a wavelength of 1064 nm. The strong thermal ablation phenomenon could be observed on vit1 BMG surface at laser energy of 200 mJ as a result of the adhibition of confining overlay. Many periodic ripples had formed on the edge of the ablated area at laser energy of 400 mJ because of the high intensity pulsed laser beam. The underlying mechanism of the periodic ripples formation could be explained by the K-H hydrodynamic instability theory. It had been shown that laser ablation with 600 mJ and 200 pulses results in the formation of many micro-cracks on the ablated area. Further analysis showed that the spatial occupation of the laser ablated area and the spacing between two adjacent ripples increased as the laser energy and the number of incident laser pulses increasing. The surface ripples feature on the edge of ablated area became more obvious with increasing laser pulses, but it was not correlated closely with the laser energies variation.

  5. Effect of Twisted Fiber Anisotropy in Cardiac Tissue on Ablation with Pulsed Electric Fields

    Science.gov (United States)

    Xie, Fei; Zemlin, Christian W.

    2016-01-01

    Background Ablation of cardiac tissue with pulsed electric fields is a promising alternative to current thermal ablation methods, and it critically depends on the electric field distribution in the heart. Methods We developed a model that incorporates the twisted anisotropy of cardiac tissue and computed the electric field distribution in the tissue. We also performed experiments in rabbit ventricles to validate our model. We find that the model agrees well with the experimentally determined ablation volume if we assume that all tissue that is exposed to a field greater than 3 kV/cm is ablated. In our numerical analysis, we considered how tissue thickness, degree of anisotropy, and electrode configuration affect the geometry of the ablated volume. We considered two electrode configurations: two parallel needles inserted into the myocardium (“penetrating needles” configuration) and one circular electrode each on epi- and endocardium, opposing each other (“epi-endo” configuration). Results For thick tissues (10 mm) and moderate anisotropy ratio (a = 2), we find that the geometry of the ablated volume is almost unaffected by twisted anisotropy, i.e. it is approximately translationally symmetric from epi- to endocardium, for both electrode configurations. Higher anisotropy ratio (a = 10) leads to substantial variation in ablation width across the wall; these variations were more pronounced for the penetrating needle configuration than for the epi-endo configuration. For thinner tissues (4 mm, typical for human atria) and higher anisotropy ratio (a = 10), the epi-endo configuration yielded approximately translationally symmetric ablation volumes, while the penetrating electrodes configuration was much more sensitive to fiber twist. Conclusions These results suggest that the epi-endo configuration will be reliable for ablation of atrial fibrillation, independently of fiber orientation, while the penetrating electrode configuration may experience problems when the

  6. The cost-effectiveness of radiofrequency catheter ablation as first-line treatment for paroxysmal atrial fibrillation

    DEFF Research Database (Denmark)

    Aronsson, Mattias; Walfridsson, Håkan; Janzon, Magnus

    2014-01-01

    AIM: The aim of this prospective substudy was to estimate the cost-effectiveness of treating paroxysmal atrial fibrillation (AF) with radiofrequency catheter ablation (RFA) compared with antiarrhythmic drugs (AADs) as first-line treatment. METHODS AND RESULTS: A decision-analytic Markov model......, based on MANTRA-PAF (Medical Antiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation) study data, was developed to study long-term effects and costs of RFA compared with AADs as first-line treatment. Positive clinical effects were found in the overall population, a gain...... of an average 0.06 quality-adjusted life years (QALYs) to an incremental cost of €3033, resulting in an incremental cost-effectiveness ratio of €50 570/QALY. However, the result of the subgroup analyses showed that RFA was less costly and more effective in younger patients. This implied an incremental cost...

  7. Catheter ablation for atrial fibrillation after an unsuccessful surgical ablation and biological prosthetic mitral valve replacement: A pilot study

    Directory of Open Access Journals (Sweden)

    Sergey E. Mamchur

    2014-08-01

    Conclusion: Catheter ablation is an effective method for AF treatment following an ineffective surgical RF ablation procedure and biological prosthetic MV replacement. The use of bioprosthetic MVs allows for performing safe catheter ablation without subsequent prosthetic dysfunction.

  8. Myocardial condition after transcoronary ablation predicts the curative effect in patients with hypertrophic obstructive cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Transcoronary ablation of septal hypertrophy (TASH) has been recommended as an option for patients with drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). However, its outcome is varied, and some factors are attributed to the diversity results.1 Up to now, there is no study on the influence of the ablated myocardium's condition on the outcome. We retrospectively analyzed the myocardial perfusion imaging (MPI) obtained before and early after TASH in our patients to explore the relationship between the ablated myocardium's condition and the clinical outcome.

  9. The effectiveness of rigid pericardial endoscopy for minimally invasive minor surgeries: cell transplantation, epicardial pacemaker lead implantation, and epicardial ablation

    Directory of Open Access Journals (Sweden)

    Kimura Takehiro

    2012-11-01

    Full Text Available Abstract Background The efficacy and safety of rigid pericardial endoscopy as the promising minimally invasive approach to the pericardial space was evaluated. Techniques for cell transplantation, epicardial pacemaker lead implantation, and epicardial ablation were developed. Methods Two swine and 5 canines were studied to evaluate the safety and efficacy of rigid pericardial endoscopy. After a double pericardiocentesis, a transurethral rigid endoscope was inserted into the pericardial space. The technique to obtain a clear visual field was examined, and acute complications such as hemodynamic changes and the effects on intra-pericardial pressure were evaluated. Using custom-made needles, pacemaker leads, and forceps, the applications for cell transplantation, epicardial pacemaker lead implantation, and epicardial ablation were also evaluated. Results The use of air, the detention of a stiff guide wire in the pericardial space, and the stretching of the pericardium with the rigid endoscope were all useful to obtain a clear visual field. A side-lying position also aided observation of the posterior side of the heart. As a cell transplantation methodology, we developed an ultrasonography-guided needle, which allows for the safe visualization of transplantation without major complications. Pacemaker leads were safely and properly implanted, which provides a better outcome for cardiac resynchronizing therapy. Furthermore, the success of clear visualization of the pulmonary veins enabled us to perform epicardial ablation. Conclusions Rigid pericardial endoscopy holds promise as a safe method for minimally invasive cell transplantation, epicardial pacemaker lead implantation, and epicardial ablation by allowing clear visualization of the pericardial space.

  10. Lesion size in relation to ablation site during radiofrequency ablation

    DEFF Research Database (Denmark)

    Petersen, H H; Chen, X; Pietersen, A;

    1998-01-01

    convective cooling by induction of a flow around the electrode tip increases lesion dimensions and power consumptions. Furthermore we conclude that for the given target temperature the power consumption is positively correlated with lesion volume (p ...This study was designed to investigate the effect of the convective cooling of the tip of the ablation electrode during temperature controlled radiofrequency ablation. In vivo two different application sites in the left ventricle of anaesthetised pigs were ablated and in vitro ablation...... larger for septal applications than apical applications (p convective cooling by induction of flow yielded larger lesion volume, depth and width (p

  11. Effects of the Learning Curve on Efficacy of Radiofrequency Ablation for Barrett's Esophagus.

    Science.gov (United States)

    Pasricha, Sarina; Cotton, Cary; Hathorn, Kelly E; Li, Nan; Bulsiewicz, William J; Wolf, W Asher; Muthusamy, V Raman; Komanduri, Srinadh; Wolfsen, Herbert C; Pruitt, Ron E; Ertan, Atilla; Chmielewski, Gary W; Shaheen, Nicholas J

    2015-10-01

    Complete eradication of Barrett's esophagus (BE) often requires multiple sessions of radiofrequency ablation (RFA). Little is known about the effects of case volume on the safety and efficacy of RFA or about the presence or contour of learning curves for this procedure. We collected data from the US RFA Patient Registry (from 148 institutions) for patients who underwent RFA for BE from July 2007 to July 2011. We analyzed the effects of the number of patients treated by individual endoscopists and individual centers on safety and efficacy outcomes of RFA. Outcomes, including stricture, bleeding, hospitalization, and complete eradication of intestinal metaplasia (CEIM), were assessed using logistic regression. The effects of center and investigator experience on numbers of treatment sessions to achieve CEIM were examined using linear regression. After we controlled for potential confounders, we found that as the experience of endoscopists and centers increased with cases, the numbers of treatment sessions required to achieve CEIM decreased. This relationship persisted after adjusting for patient age, sex, race, length of BE, and presence of pretreatment dysplasia (P .05). Based on analysis of a large multicenter registry, efficiency of the treatment, as measured by number of sessions needed to achieve CEIM, increased with case volume, indicating a learning curve effect. This trend began to disappear after treatment of approximately 30 patients by the center or individual endoscopist. However, there was no significant association between safety or efficacy outcomes and previous case volume. Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.

  12. Nanosecond laser ablation of bulk Al, Bronze, and Cu: ablation rate saturation and laserinduced oxidation

    OpenAIRE

    R. Maisterrena-Epstein; S. Camacho-López; L. Escobar-Alarcón; M. A. Camacho-López

    2007-01-01

    In this work we report about the characteristics of nanosecond laser ablation, in atmospheric air, of bulk Al, Bronze, and Cu. Average per pulse laser ablation rate and its dependence on ablation depth is presented for these three metals. We will demonstrate and discuss some distinctive features of the ablation saturation effect of the above metals. We will also present results on laser-induced oxidation of the metals which results off the ablation event. We studied the laser-induced oxidatio...

  13. Chronic Effect of Transrectal Split-Focus Ultrasonic Ablation on Canine Prostatic Tissue

    National Research Council Canada - National Science Library

    SASAKI, Kazuaki; AZUMA, Takashi; KAWABATA, Ken-ichi; UMEMURA, Shin-ichiro; TANAKA, Ryou; YAMANE, Yoshihisa; SHIMODA, Minoru

    2006-01-01

    ... prostatic tissue without injuring surrounding tissues. The prostates of 5 dogs were transrectally treated with split-focus ablation at a peak intensity in the water of 1.7 kW/cm2 for 4 s (4 shots...

  14. Bruce Unit 1 and 2 preheater condition assessment and refurbishment

    Energy Technology Data Exchange (ETDEWEB)

    King, P.; Machowski, C.; McGillivray, R. [Babcock and Wilcox Canada Ltd., Cambridge, ON (Canada); Durance, D. [Bruce Power, Tiverton, ON (Canada)

    2008-07-01

    Bruce Units 1 to 4 were shut down during the 1990s, largely as a consequence of tube degradation resulting from inappropriate steam generator secondary side water chemistries. Following a condition assessment, Bruce Power restarted Units 3 and 4 and is currently refurbishing Units 1 and 2. In order to assess the condition of the Unit 1 and Unit 2 preheaters and determine their suitability for extended operation, inspection, maintenance and assessment activities have been conducted. Eddy current and visual inspection have revealed vessels in generally good condition. Secondary side internals appear largely undergraded. Some tube to support fretting has been observed, and a number of tubes have been removed from service because of debris fretting concerns. To prepare for return to service, the primary side divider plates have been replaced and the tubes have been ID cleaned to restore the preheater to its original condition. This paper summarizes the inspection planning, findings, assessment for extended operation and maintenance activities undertaken. (author)

  15. Theory and Numerics of Gravitational Waves from Preheating after Inflation

    CERN Document Server

    Dufaux, Jean Francois; Felder, Gary N; Kofman, Lev; Uzan, Jean-Philippe

    2007-01-01

    Preheating after inflation involves large, time-dependent field inhomogeneities, which act as a classical source of gravitational radiation. The resulting spectrum might be probed by direct detection experiments if inflation occurs at a low enough energy scale. In this paper, we develop a theory and algorithm to calculate, analytically and numerically, the spectrum of energy density in gravitational waves produced from an inhomogeneous background of stochastic scalar fields in an expanding universe. We derive some generic analytical results for the emission of gravity waves by stochastic media of random fields, which can test the validity/accuracy of numerical calculations. We contrast our method with other numerical methods in the literature, and then we apply it to preheating after chaotic inflation. In this case, we are able to check analytically our numerical results, which differ significantly from previous works. We discuss how the gravity wave spectrum builds up with time and find that the amplitude an...

  16. Preheating and Affleck-Dine leptogenesis after thermal inflation

    CERN Document Server

    Felder, G N; Park, W I; Stewart, E D; Felder, Gary N.; Kim, Hyunbyuk; Park, Wan-Il; Stewart, Ewan D.

    2007-01-01

    Previously, we proposed a model of low energy Affleck-Dine leptogenesis in the context of thermal inflation. The lepton asymmetry is generated at the end of thermal inflation, which occurs at a relatively low energy scale with the Hubble parameter somewhere in the range $1 \\keV \\lesssim H \\lesssim 1 \\MeV$. Thus Hubble damping will be ineffective in bringing the Affleck-Dine field into the lepton conserving region near the origin, leaving the possibility that the lepton number could be washed out. Previously, we suggested that preheating could damp the amplitude of the Affleck-Dine field allowing conservation of the lepton number. In this paper, we demonstrate numerically that preheating does efficiently damp the amplitude of the Affleck-Dine field and that the lepton number is conserved as the result. In addition to demonstrating a crucial aspect of our model, it also opens the more general possibility of low energy Affleck-Dine baryogenesis.

  17. Effect of optical fiber type and absorption medium on the endovenous laser ablation mechanism

    Science.gov (United States)

    Ignatieva, N. Yu; Zakharkina, O. L.; Mazayshvili, C. V.; Bagratashvili, V. N.; Lunin, V. V.

    2017-10-01

    Our experimental investigation was aimed at revealing the mechanism behind the action of laser radiation on venous wall under endovenous laser ablation conditions. We determined the critical laser power P cr at which the objective effect of complete denaturation of the vascular tissue collagen was attained for two types of optical fiber in the presence and absence of blood cells. We demonstrated that for the radial optical fiber the presence of blood cells had no effect on the magnitude of P cr, which came to 4.3  ±  0.1 and 5.6  ±  01 W for 1.56 and 1.47 µm lasers, respectively. For the bare fiber and 1.56 µm laser, P cr increased up to 5.2  ±  0.2 W in a blood-filled vessel and up to 7.1  ±  0.2 W when the blood was replaced by a sodium chloride solution. Our data show that the heating and degradation of insufficient veins go on more effectively when the tissue is heated by laser radiation directly absorbed therein, rather than the red-hot carbonized optical fiber tip.

  18. [Doppler effect on width of characteristic line in plasma induced by pulsed laser ablating Al].

    Science.gov (United States)

    Song, Yi-Zhong; He, An-Zhi

    2005-05-01

    Aluminum (Al) plasma was induced with a pulsed Nd: YAG laser beam ablating Al target in Ar. Time-resolved information of the plasma radiation was taken with time-resolved technique, and the spectra of the radiation were recorded with an optical multi-path analyzer (OMA III ), whereupon, time-resolved spectra of the plasma radiation induced by pulsed laser were acquired. Based on the experiment data, Al resonant double lines, Al I 396.15 nm, Al I 394.40 nm, were respectively fitted with Lorentz, Gauss and their linear integrated function (abbr. Integrated function), whereupon, Lorentz and Gauss elements were separated from the experiment data profile curve. By contrasting Lorentz with Gauss curve separated, it was found that the experiment curve mainly consisted of Lorentz element, a with little Gauss. By contrasting Lorentz with Integrated fitting curve for experiment data, a visual picture of the characteristic lines broadened by Doppler effect was exhibited. According to the visual picture, the increase of full half-high width of the characteristic line broadened by Doppler effect was estimated. It was about 2 x 10(-)3 -8 x 10(-3) nm, approximating the theoretical value 6.7 x 10(-)3 nm. As a result, Doppler effect on the width of characteristic lines in the plasma could be reasonably explained by curve fitting analysis and theoretical calculation.

  19. Non-equilibrium Goldstone phenomenon in tachyonic preheating

    CERN Document Server

    Borsanyi, S; Sexty, D; Borsanyi, Sz.

    2003-01-01

    The dominance of the direct production of elementary Goldstone waves is demonstrated in tachyonic preheating by determining numerically the evolution of the dispersion relation, the equation of state and the kinetic power spectra for the angular degree of freedom of the complex matter field. The importance of the domain structure in the order parameter distribution for the quantitative understanding of the excitation mechanism is emphasized. Evidence is presented for the very early decoupling of the low-momentum Goldstone modes.

  20. Image-guided ablation of painful metastatic bone tumors: a new and effective approach to a difficult problem

    Energy Technology Data Exchange (ETDEWEB)

    Callstrom, Matthew R.; Charboneau, J. William; Atwell, Thomas D.; Farrell, Michael A.; Welch, Timothy J.; Maus, Timothy P. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Goetz, Matthew P.; Rubin, Joseph [Mayo Clinic, Department of Oncology, Rochester, MN (United States)

    2006-01-01

    Painful skeletal metastases are a common problem in cancer patients. Although external beam radiation therapy is the current standard of care for cancer patients who present with localized bone pain, 20-30% of patients treated with this modality do not experience pain relief, and few further options exist for these patients. For many patients with painful metastatic skeletal disease, analgesics remain the only alternative treatment option. Recently, image-guided percutaneous methods of tumor destruction have proven effective for treatment of this difficult problem. This review describes the application, limitations, and effectiveness of percutaneous ablative methods including ethanol, methyl methacrylate, laser-induced interstitial thermotherapy (LITT), cryoablation, and percutaneous radiofrequency ablation (RFA) for palliation of painful skeletal metastases. (orig.)

  1. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice

    Science.gov (United States)

    The orexigenic hormone ghrelin is important in diabetes because it has an inhibitory effect on insulin secretion. Ghrelin ablation in leptin-deficient ob/ob (Ghrelin(-/-):ob/ob) mice increases insulin secretion and improves hyperglycemia. The physiologically relevant ghrelin receptor is the growth ...

  2. Experimental research on bitumen preheating (fluidization) by using solar energy in passive mode

    Energy Technology Data Exchange (ETDEWEB)

    Luminosu, Ioan [Department of Physics, ' Politehnica' University Timisoara, 1, Regina Maria Plaza, RO 300004, Timisoara (Romania); Fara, Laurentiu [Department of Physics, ' ' Politehnica' ' University Bucharest, 313, Splaiul Independentei Blvd, RO 060032, Bucuresti (Romania)

    2009-01-15

    An important aim of worldwide research engineering is to identify new industries to introduce solar energy installations for average thermal level. Due to the mechanical and thermal properties of bitumen, such as the 44-49 C softening point of D80/100 type bitumen, this material can be preheated by using solar thermal installations. The Physics Department of 'Politehnica' University of Timisoara designed and studied a laboratory installation for preheating in environmental conditions an amount of 25.1 kg of bitumen up to 55 C per day. The paper developed a previous original research regarding bitumen preheating by using solar energy. The experimental installation was improved and experimental data were statistically processed. The main improvements were based on:-increasing the amount of incident solar radiation by: (a) reducing the height of the brick walls and replacing them with transparent glass plates; (b) painting the inner faces of the brick walls in white; -cutting down thermal losses by: (a) achievement of the double greenhouse effect in the transparent areas of the installation; (b) change of the brick walls into passive walls. The performances of the installation were improved as follows:-increasing time of the bitumen temperature increased from 7 hours to 8 hours, in the interval 8 am-4 pm; -bitumen maximum temperature increased from 55 to 63.3 C; -average temperature in bitumen increased from 41.4 to 46.4 C; -maximum efficiency increased from 12 to 14.4%; -daily average efficiency increased from 6.3 to 7.3%; -maximum difference between the bitumen temperature and environmental one increased from 24 to 32 C. (author)

  3. The effect of ambient pressure on ejecta sheets from free-surface ablation

    KAUST Repository

    Marston, J. O.

    2016-04-16

    We present observations from an experimental study of the ablation of a free liquid surface promoted by a focused laser pulse, causing a rapid discharge of liquid in the form of a very thin conical-shaped sheet. In order to capture the dynamics, we employ a state-of-the-art ultra-high-speed video camera capable of capturing events at (Formula presented.) fps with shutter speeds down to 20 ns, whereby we were able to capture not only the ejecta sheet, but also the shock wave, emerging at speeds of up to 1.75 km/s, which is thus found to be hypersonic (Mach 5). Experiments were performed at a range of ambient pressures in order to study the effect of air drag on the evolution of the sheet, which was always observed to dome over, even at pressures as low as 3.8 kPa. At reduced pressures, the extended sheet evolution led to the formation of interference fringe patterns from which, by comparison with the opening speed of rupture, we were able to determine the ejecta thickness. © 2016, Springer-Verlag Berlin Heidelberg.

  4. Effect of gold nano-particle layers on ablative acceleration of plastic foil targets

    Energy Technology Data Exchange (ETDEWEB)

    Dhareshwar, L J; Gupta, N K; Chaurasia, S [Bhabha Atomic Research Centre, Mumbai (India); Ayyub, P; Kulkarni, N [Tata Institute of Fundamental Research, Mumbai (India); Badziak, J; Pisarczyk, T; Kasperczuk, A; Parys, P; Rosinski, M; Wolowski, J [Institute of Plasma Physics and Laser Microfusion, 01-497 Warsaw (Poland); Krousky, E; Krasa, J; Masek, K; Pfeifer, M; Skala, J; Ullschmied, J; Velyhan, A; Margarone, D [PALS Research Centre ASCR, 1822 Prague 8 (Czech Republic); Mezzasalma, A, E-mail: dharesh@barc.gov.i [University of Messina (Italy)

    2010-08-01

    Presence of nano-particles on target surface has been observed to lead to increased laser absorption of laser pulse in plasma. Therefore, a coating of nano-particles on foil targets could lead to an enhanced ablative acceleration. The work presented in this paper concerns this possibility. The results of experiments performed with PALS laser system (125 J, {approx}250 ps at 1.3 {mu}m) with a focused intensity of about 10{sup 14} W/cm{sup 2} are presented. 15 {mu}m thick Polyethylene teraphthalate (C{sub 10} H{sub 8} O{sub 4}){sub n} or PET foils show an almost 40% increase in target movement when coated with a layer of gold nano-particles. Comparison between targets with coating of bulk gold and nano-gold shows about 15% higher target movement in gold nano-particle coated PET targets as compared to bulk gold coating. This result is a clear indication of enhanced laser energy absorption in targets with nano-structured surface of gold. We also present evidence to show the effect of nano-particle coating on lateral thermal conduction.

  5. Radiofrequency ablation of osteoid osteoma

    NARCIS (Netherlands)

    Vanderschueren, Geert Maria Joris Michael

    2009-01-01

    The main purpose of this thesis was to evaluate the effectiveness and safety of CT-guided radiofrequency ablation for the treatment of spinal and non-spinal osteoid osteomas. Furthermore, the technical requirements needed for safe radiofrequency ablation and the clinical outcome after radiofrequency

  6. Influence of effective number of pulses on the morphological structure of teeth and bovine femur after femtosecond laser ablation.

    Science.gov (United States)

    Nicolodelli, Gustavo; Lizarelli, Rosane de Fátima Zanirato; Bagnato, Vanderlei Salvador

    2012-04-01

    Femtosecond lasers have been widely used in laser surgery as an instrument for contact-free tissue removal of hard dental, restorative materials, and osseous tissues, complementing conventional drilling or cutting tools. In order to obtain a laser system that provides an ablation efficiency comparable to mechanical instruments, the laser pulse rate must be maximal without causing thermal damage. The aim of this study was to compare the different morphological characteristics of the hard tissue after exposure to lasers operating in the femtosecond pulse regime. Two different kinds of samples were irradiated: dentin from human extracted teeth and bovine femur samples. Different procedures were applied, while paying special care to preserving the structures. The incubation factor S was calculated to be 0.788±0.004 for the bovine femur bone. These results indicate that the incubation effect is still substantial during the femtosecond laser ablation of hard tissues. The plasma-induced ablation has reduced side effects, i.e., we observe less thermal and mechanical damage when using a superficial femtosecond laser irradiation close to the threshold conditions. In the femtosecond regime, the morphology characteristics of the cavity were strongly influenced by the change of the effective number of pulses.

  7. Effect of sample storage conditions on Er:YAG laser ablation of enamel, dentin, and bone

    Science.gov (United States)

    Selting, Wayne J.

    2007-02-01

    Samples of bone, dentin and enamel were stored in distilled water, 10% neutral buffered formalin, 70% ethyl alcohol or 6% sodium hypochlorite solutions for fifteen days. Other samples were stored in the same solutions for 36 hours and then transferred to distilled water for the remainder of the fifteen day period. Finally, samples than had been stored dry for up to 5 years were rehydrated and ablated. All enamel specimens appeared unaffected by the storage conditions. Dentin samples were very significantly affected by all storage methods. Bone samples were affected by most storage conditions. Samples stored in sodium hypochlorite had as much as a 100 percent increase in ablation rate. Surprisingly, dry stored samples that were reconstituted for 36 hours ablated at virtually the same rate as those stored in distilled water. None of the storage conditions studied produced ablation rates that mirrored in vivo ablation. Sterilization by autoclave is the only reliable and safe method studied but cannot be used on teeth with amalgam fillings for safety reasons. Teeth with fillings should be stored in 10% neutral bufferred formalin for a minimum of one week.

  8. A dose-effect correlation for radioiodine ablation in differentiated thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Flux, Glenn D.; Chittenden, Sarah J.; Buckley, Susan; Hindorf, Cecilia [Royal Marsden NHS Foundation Trust, Department of Physics, Sutton, Surrey (United Kingdom); Haq, Masud; Newbold, Kate; Harmer, Clive L. [Royal Marsden NHS Foundation Trust, Thyroid Unit, Sutton, Surrey (United Kingdom)

    2010-02-15

    The aim of this study was to determine the range of absorbed doses delivered to thyroid remnants, blood, and red marrow from fixed administrations of radioiodine and to ascertain whether the success of ablation is more dependent on these absorbed doses than on the administered activity. Twenty-three patients received 3,000 MBq radioiodine following near-total thyroidectomy. The maximum absorbed dose to remnants was calculated from subsequent single photon emission tomography scans. Absorbed doses delivered to blood and red marrow were calculated from blood samples and from whole-body retention measurements. The protein bound iodine (PBI) was also calculated. Maximum absorbed doses to thyroid remnants ranged from 7 to 570 Gy. Eighteen of the 23 patients had a successful ablation. A significant difference was seen between the absorbed doses delivered to thyroid remnants, blood, and red marrow for those patients that had a successful ablation compared to those with a failed ablation (p = 0.030, p = 0.043 and p = 0.048, respectively). The difference between the PBI values acquired at day 1 and day 6 were also indicative of response (p = 0.074). A successful ablation is strongly dependent on the absorbed dose to the thyroid remnant. Dosimetry-based personalized treatment can prevent both sub-optimal administrations, which entails further radioiodine therapy, and excessive administration of radioactivity, which increases the potential for radiation toxicity. (orig.)

  9. Effect of temperature on the characteristics of ZnO nanoparticles produced by laser ablation in water

    Indian Academy of Sciences (India)

    ELMIRA SOLATI; DAVOUD DORRANIAN

    2016-12-01

    Effect of the water temperature on the characteristics of zinc oxide nanoparticles (NPs) produced by laser ablation process is investigated experimentally. The fundamental wavelength of a Q-switched Nd:YAG laserwas employed to irradiate a high-purity zinc plate in distilled water at different temperatures of 0, 20, 40 and 60$^{\\circ}$C. The produced NPs were diagnosed by UV–vis–NIR spectroscopy, X-ray diffraction method, transmission electronmicroscopy and scanning electron microscopy. Results show that with increase in the water temperature from 20 to 60$^{\\circ}$C, size of NPs decreases while their bandgap energy increases. Maximum ablation rate occurs at the highesttemperature. Crystalinity also increases with increase in the water temperature. The abnormal behaviour of water at 0–4$^{\\circ}$C affects the NPs characteristics.

  10. Partial ablation of uropygial gland effects on growth hormone concentration and digestive system histometrical aspect of akar putra chicken.

    Science.gov (United States)

    Jawad, Hasan S A; Lokman, I H; Zuki, A B Z; Kassim, A B

    2016-04-01

    Partial ablation of the uropygial gland is being used in the poultry industry as a new way to enhance body performance of chickens. However, limited data are available estimating the efficacy of partial uropygialectomy (PU) to improve body organ activity. The present study evaluated the effect of partial ablation of the uropygial gland on the serum growth hormone concentration level and digestive system histology of 120 Akar Putra chickens in 5 trials with 3 replicates per trial. The experimental treatments consisted of a control treatment T1; partial ablation of the uropygial gland was applied in the T2, T3, T4, and T5 treatments at 3, 4, 5, and 6 wk of age, respectively. Feed and water were provided ad libitum. All treatment groups were provided the same diet. Venous blood samples were collected on wk 7, 10, and 12 to assay the levels of growth hormone concentration. On the last d of the experiment, 4 birds per replicate were randomly isolated and euthanized to perform the necropsy. Digestive system organs' cross sections were measured by a computerized image analyzer after being stained with haematoxylin and eosin. In comparison with the control group, surgical removal of the uropygial gland, especially at wk 3, had a greater (Pgrowth hormone concentration level at wk 7 and (P<0.01) effects at wk 12 in both sexes. This study provides a novel and economic alternative to enhance the body performance of poultry in general and Akar Putra chickens particularly.

  11. Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.

    Directory of Open Access Journals (Sweden)

    Rosemary C Challis

    Full Text Available We recently reported that olfactory sensory neurons in the dorsal zone of the mouse olfactory epithelium exhibit drastic location-dependent differences in cilia length. Furthermore, genetic ablation of type III adenylyl cyclase (ACIII, a key olfactory signaling protein and ubiquitous marker for primary cilia, disrupts the cilia length pattern and results in considerably shorter cilia, independent of odor-induced activity. Given the significant impact of ACIII on cilia length in the dorsal zone, we sought to further investigate the relationship between cilia length and ACIII level in various regions throughout the mouse olfactory epithelium. We employed whole-mount immunohistochemical staining to examine olfactory cilia morphology in phosphodiesterase (PDE 1C-/-;PDE4A-/- (simplified as PDEs-/- hereafter and ACIII-/- mice in which ACIII levels are reduced and ablated, respectively. As expected, PDEs-/- animals exhibit dramatically shorter cilia in the dorsal zone (i.e., where the cilia pattern is found, similar to our previous observation in ACIII-/- mice. Remarkably, in a region not included in our previous study, ACIII-/- animals (but not PDEs-/- mice have dramatically elongated, comet-shaped cilia, as opposed to characteristic star-shaped olfactory cilia. Here, we reveal that genetic ablation of ACIII has drastic, location-dependent effects on cilia architecture in the mouse nose. These results add a new dimension to our current understanding of olfactory cilia structure and regional organization of the olfactory epithelium. Together, these findings have significant implications for both cilia and sensory biology.

  12. Low SO2 Emission Preheaters for Cement Production

    DEFF Research Database (Denmark)

    Rasmussen, Martin Hagsted

    showed that this figure could be between 90 kJ/mole and 140 kJ/mole, with a corresponding change of preexponential factors. The ability to predict emissions is very important in the design of cement plants. In this thesis the zone model concept has been applied to the modelling of the cyclone stages...... in a preheater tower. The idea is to account for the complex flow pattern in a cyclone stage by dividing it into zones, each zone having special features. In this manner the model can account for gas/solid heat exchange, gas/solid separation, different gas and solid residence times, etc. The model was evaluated...

  13. Effects of eyestalk ablation on moulting and growth of penaeid prawn Metapenaeus dobsoni (de Man)

    Digital Repository Service at National Institute of Oceanography (India)

    Venkitraman, P.R.; Jayalakshmy, K.V.; Balasubramanian, T.; Nair, M.; Nair, K.K.C.

    eyestalk ablation reduced the dry weight of moult and this decrease in the rate increased after each subsequent moult. In the larger size group, values of protein efficiency ration (PER) were almost same as that of the lower size group. The UEA prawns...

  14. Atomistic simulation of laser ablation of gold : Effect of pressure relaxation

    NARCIS (Netherlands)

    Norman, G. E.; Starikov, S. V.; Stegailov, V. V.

    2012-01-01

    The process of ablation of a gold target by femto- and picosecond laser radiation pulses has been studied by numerical simulations using an atomistic model with allowance for the electron subsystem and the dependence of the ion-ion interaction potential on the electron temperature. Using this potent

  15. Measuring preheat in laser-drive aluminum using velocity interferometer system for any reflector: Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Shu, Hua; Fu, Sizu; Huang, Xiuguang; Wu, Jiang; Xie, Zhiyong; Zhang, Fan; Ye, Junjian; Jia, Guo; Zhou, Huazhen [Shanghai Institute of Laser Plasma, P.O. BOX 800-229, Shanghai 201800 (China)

    2014-08-15

    In this paper, we systematically study preheating in laser-direct-drive shocks by using a velocity interferometer system for any reflector (VISAR). Using the VISAR, we measured free surface velocity histories of Al samples over time, 10–70 μm thick, driven directly by a laser at different frequencies (2ω, 3ω). Analyzing our experimental results, we concluded that the dominant preheating source was X-ray radiation. We also discussed how preheating affected the material initial density and the measurement of Hugoniot data for high-Z materials (such as Au) using impedance matching. To reduce preheating, we proposed and tested three kinds of targets.

  16. Effects of radiofrequency ablation on individual renal function: assessment by technetium-99m mercaptoacetyltriglycine renal scintigraphy.

    Directory of Open Access Journals (Sweden)

    Nasu,Yasutomo

    2006-04-01

    Full Text Available We quantitatively evaluated total and individual renal function by technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3 renal scintigraphy before and after radiofrequency ablation (RFA of renal tumors. Eleven patients who underwent Tc-99m MAG3 renal scintigraphy 1 week before and after RFA were evaluated (7 men and 4 women ; age range : 23-83 years ; mean age : 60.6 years. Five patients had solitary kidneys, and five had normally or minimally functioning contralateral kidneys. One patient had a renal cell carcinoma in the contralateral kidney. One patient with a solitary kidney underwent RFA a second time for a residual tumor. In patients with a solitary kidney, MAG3 clearance decreased after 5 of 6 RFAs, and in patients with a normally functioning contralateral kidney, MAG3 clearance decreased after 4 of 5 RFAs, but no significant differences were observed between before and after treatments. In addition to the total MAG3 clearance, the split MAG3 clearance was evaluated in patients with a normally functioning contralateral kidney. MAG3 clearance decreased in 4 of 5 treated kidneys, while it adversely increased in the contralateral kidneys after 4 of 5 RFAs. No significant differences, however, were observed between before and after treatments. The results of our study revealed no significant differences in sCr, BUN, CCr, or MAG3 clearance between pre- and post-RFA values. These results support data regarding the functional impact and safety of renal RFA in published reports. We evaluated total and individual renal function quantitatively using Tc-99m MAG3 renal scintigraphy before and after treatment. This scintigraphy was very useful in assessing the effects of RFA on renal function.

  17. Developing a Pre-Heat Platform for MagLIF with Z-Beamlet

    Science.gov (United States)

    Geissel, Matthias; Harvey-Thompson, Adam J.; Awe, T. J.; Bliss, D. E.; Glinsky, M. E.; Campbell, E. M.; Gomez, M. R.; Harding, E.; Hansen, S. B.; Jennings, C. A.; Kimmel, M. W.; Knapp, P. F.; Lewis, S. M.; McBride, R. D.; Peterson, K.; Schollmeier, M.; Scoglietti, D. J.; Sefkow, A. B.; Shores, J. E.; Sinars, D. B.; Rochau, G. A.; Slutz, S. A.; Smith, I. C.; Weiss, M. R.; Porter, J. L.

    2016-10-01

    Sandia's Magnetized Liner Inertial Fusion Program has put one of the main objectives towards developing standard platform for a `preconditioned' target, providing a scenario that reproducibly delivers pre-heated fuel. The majority of this effort has been done at the ``Pecos'' Target Area using Sandia's Z-Beamlet laser to provide the pre-heat energy, just like for fully integrated MagLIF experiments. The nature and magnitude of Laser-Plasma-Instabilities during this process are particularly important, since they can lead to less energy in the fuel (backscatter processes) or to energy deposition in less desirable areas (filamentation/scatter). We present results for Stimulated Brillouin Backscatter and forward scatter, and show the effect of the laser pulse shape to laser-entrance-hole transmission and blast wave propagation in the fuel. Sandia is a multi-program laboratory managed and operated by Sandia Corp., a wholly owned subsidiary of Lockheed Martin Corp., for the U.S. DOE's Nat'l Nucl. Sec. Admin. under contract DE-AC04-94AL85000.

  18. Combustion Air Pre-heating from Ash Sensible Heat in Municipal Waste Incineration Systems

    Directory of Open Access Journals (Sweden)

    Zakariya Kaneesamkandi

    2014-01-01

    Full Text Available Heat recovery from bottom ash is more important in municipal waste combustion systems than in any other solid fuel combustion since almost 50% of it comprises of non-combustibles. In this study, an ash cooling system using air as the cooling medium has been modeled for pre-heating the combustion air. Air cooling has several advantages over water cooling methods. The study involves modeling using Gambit tool and is solved with the fluent solver. Municipal solid waste incineration systems have the advantage of being located near the waste collection area apart from the high volume reduction ratio. Improvements in the emission control systems and combustion technology can make incineration a highly feasible disposal method. Low furnace temperature due to heat losses through fuel moisture loss and ash sensible heat loss has been a disadvantage with these systems. In this study, a small percentage of the combustion air is pre-heated in a non-contact type heat exchanger and its effect on the available energy of combustion gases at the evaporator outlet is studied. The study is performed for two different waste samples. Results indicate significant increase in available energy at the evaporator outlet and better relative performance for the lower grade fuel. A comparison is made with similar methods reported in the literature along with a brief discussion on the methodologies adopted. The results confirm the importance of installing ash sensible heat recovery mechanism for waste incineration systems as well as the feasibility of the air based method.

  19. An economic and performance design study of solar preheaters for domestic hot water heaters in North Carolina

    Energy Technology Data Exchange (ETDEWEB)

    Jones, C.B.; Smetana, F.O.

    1977-03-01

    The performance and estimated material costs for several solar preheaters for domestic hot water heaters using insolation levels present in North Carolina are presented. The effects of monthly variations in insolation and the direction of incident radiation are included. Demand is assumed at 13 gallons (49.2 liters) per day per person. The study shows that a closed circulation system with 82 gallons (310 liters) of preheated storage and 53.4 cu ft (4.94 cu m) of collector surface with single cover can be expected to cost about $800 and to repay it capital cost and interest (at 8%) in 5.2 years, assuming present electric rates increase at 5% per year.

  20. An economic and performance design study of solar preheaters for domestic hot water heaters in North Carolina

    Science.gov (United States)

    Jones, C. B.; Smetana, F. O.

    1977-01-01

    The performance and estimated material costs for several solar preheaters for domestic hot water heaters using isolation levels present in North Carolina are presented. The effects of monthly variations in isolation and the direction of incident radiation are included. Demand is assumed at 13 gallons (49.2 liters) per day per person. The study shows that a closed circulation system with 82 gallons (310 liters) of preheated storage and 53.4 cu ft (4.94 cu m) of collector surface with single cover can be expected to cost about $800 and to repay it capital cost and interest (at 8%) in 5.2 years, assuming present electric rates increase at 5% per year.

  1. Design of a DCS Based Model for Continuous Leakage Monitoring System of Rotary Air Preheater of a Thermal Power Plant

    Directory of Open Access Journals (Sweden)

    Madan BHOWMICK

    2011-01-01

    Full Text Available The leakage in rotary air preheater makes a considerable contribution to the reduced overall efficiency of fossil-fuel-fired thermal power plants and increase the effect on environment. Since it is normal phenomenon, continuous monitoring of leakage is generally omitted in most power plants. But for accurate analysis of the operation of the thermal power plant, this leakage monitoring plays a vital role. In the present paper, design of a DCS based model for continuous leakages monitoring of rotary air preheater has been described. In the proposed model, the existing DCS based instrumentation system has been modified and online leakage monitoring system has been developed. This model has been installed in a captive power plant with high capacity boilers and very much satisfactory operation of this system has been observed. The observed online data along with their analysis results are presented in this paper.

  2. An analysis of metallurgical ladle preheating; Uma analise do processo de pre-aquecimento da panela de aciaria

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Eliana F. [Ouro Preto Univ., MG (Brazil). Escola de Minas; Figueira, Renato M. [Minas Gerais Univ., Belo Horizonte, MG (Brazil). Dept. de Engenharia Metalurgica

    1996-12-31

    An analysis of the pre-heating effects of the siderurgical ladle refractory lining on the steel making process is developed. The modeling is based essentially on the transient two-dimensional heat conduction equation, expressed in cylindrical coordinates, and also taking into account radiation and convection boundary conditions. The solution procedure is accomplished by means of an `ANSYS` F.E.M. scheme. The analysis enables the evaluation of the preheating influence on the other phases of the complete continuous casting process . The conditions which have to be used in the control of the whole process can be determined by this simulation, enabling the optimization of energy consumption, refractory lining wear, and holding time. (author) 10 refs., 6 figs.

  3. Laser ablation for the synthesis of carbon nanotubes

    Science.gov (United States)

    Holloway, Brian C; Eklund, Peter C; Smith, Michael W; Jordan, Kevin C; Shinn, Michelle

    2012-11-27

    Single walled carbon nanotubes are produced in a novel apparatus by the laser-induced ablation of moving carbon target. The laser used is of high average power and ultra-fast pulsing. According to various preferred embodiments, the laser produces and output above about 50 watts/cm.sup.2 at a repetition rate above about 15 MHz and exhibits a pulse duration below about 10 picoseconds. The carbon, carbon/catalyst target and the laser beam are moved relative to one another and a focused flow of "side pumped", preheated inert gas is introduced near the point of ablation to minimize or eliminate interference by the ablated plume by removal of the plume and introduction of new target area for incidence with the laser beam. When the target is moved relative to the laser beam, rotational or translational movement may be imparted thereto, but rotation of the target is preferred.

  4. Laser ablation for the synthesis of carbon nanotubes

    Science.gov (United States)

    Holloway, Brian C. (Inventor); Eklund, Peter C. (Inventor); Smith, Michael W. (Inventor); Jordan, Kevin C. (Inventor); Shinn, Michelle (Inventor)

    2012-01-01

    Single walled carbon nanotubes are produced in a novel apparatus by the laser-induced ablation of moving carbon target. The laser used is of high average power and ultra-fast pulsing. According to various preferred embodiments, the laser produces and output above about 50 watts/cm.sup.2 at a repetition rate above about 15 MHz and exhibits a pulse duration below about 10 picoseconds. The carbon, carbon/catalyst target and the laser beam are moved relative to one another and a focused flow of "side pumped", preheated inert gas is introduced near the point of ablation to minimize or eliminate interference by the ablated plume by removal of the plume and introduction of new target area for incidence with the laser beam. When the target is moved relative to the laser beam, rotational or translational movement may be imparted thereto, but rotation of the target is preferred.

  5. The occurrence of new arrhythmias after catheter-ablation of accessory pathway: Delayed arrhythmic side-effect of curative radiofrequency lesion?

    Directory of Open Access Journals (Sweden)

    Mujović Nebojša

    2011-01-01

    Full Text Available Introduction. New arrhythmias (NA may appear late after accessory pathway (AP ablation, but their relation to curative radiofrequency (RF lesion is unknown. Objective. The aim of this study was to determine the prevalence and predictors for NA occurrence after AP ablation and to investigate pro-arrhythmic effect of RF. Methods. Total of 124 patients (88 males, mean age 43±14 years with Wolff-Parkinson-White syndrome and single AP have been followed after successful RF ablation. Post-ablation finding of arrhythmia, not recorded before the procedure, was considered a NA. The origin of NA was assessed by analysis of P-wave and/or QRS-complex morphology, and, thereafter, it was compared with locations of previously ablated APs. Results. Over the follow-up of 4.3±3.9 years, NA was registered in 20 patients (16%. The prevalence of specific NAs was as follows: atrioventricular (AV block 0.8%, atrial premature beats 1.6%, atrial fibrillation 5.4%, atrial flutter 0.8%, sinus tachycardia 4.8%, ventricular premature beats (VPBs 7.3%. Multivariate Cox-regression analysis identified (1 pre-ablation history of pathway-mediated tachyarrhythmias >10 years (HR=3.54, p=0.016 and (2 septal AP location (HR=4.25, p=0.003, as the independent predictors for NA occurrence. In four NA cases (two cases of septal VPBs, one of typical AFL and one of AV-block presumed NA origin was identified in the vicinity of previous ablation target. Conclusion. NAs were found in 16% of patients after AP elimination. In few of these cases, late on-site arrhythmic effect of initially curative RF lesion might be possible. While earlier intervention could prevent NA occurrence, closer follow-up is advised after ablation of septal AP.

  6. 预热工艺对钢化玻璃性能的影响%Influence of Preheating Process on Tempered Glass Properties

    Institute of Scientific and Technical Information of China (English)

    赵旭东; 张晓娟

    2015-01-01

    Preheat under different conditions (other things being equal), double chamber strong convection horizontal tempering furnace was carried out on 6mm clear glass tempered processing, analyzed the effects of preheating parameters on the performance of the tempered glass, and the results are discussed.%在不同的预热条件(其它条件相同)下,利用双室强对流水平钢化炉对6 mm白玻进行钢化处理,分析了预热参数对钢化玻璃性能的影响,并对结果进行了讨论.

  7. Microstructures and properties of non-preheated hardfacing welding

    Institute of Scientific and Technical Information of China (English)

    Yang Shanglei; Zou Zengda; Lü Xueqin; Lou Songnian

    2007-01-01

    A new type of non-preheated hardfacing electrode was developed using H08A as the core and the coat contents including ferrotitanium, ferrovanadium, graphite, rutile etc. The microstructures and properties of hardfacing metal were systematically researched. The results show the hardness of hardfacing metal increases with increasing of ferrotitanium, ferrovanadium, graphite in the coat, but the crack resistance and processing weldability become worse. The carbides formed by arc metallurgic reaction are uniformly dispersed in the matrix structure. The phases of hardfacing metal consist of α-Fe, γ-Fe, VC, TiC and Fe3C. The carbides are compression aggregation of TiC and VC, and their appearances present irregular block. The matrix microstructure of hardfacing metal is lath martensite. The hardfacing layers with better crack resistance and wearability are achieved and no visible cracks occur when using non-preheated electrode in continuous welding process. Hardness of hardfacing metal is more than 60HRC, and its relative wearability is five times of wearability of D667 electrode in abrasive wear test.

  8. Production of biohydrogen from hydrolyzed bagasse with thermally preheated sludge

    Energy Technology Data Exchange (ETDEWEB)

    Chairattanamanokorn, Prapaipid [Environmental Technology Unit, Department of Environmental Science, Kasetsart University, Bangkok (Thailand); Research Group for Development of Microbial Hydrogen Production Process from Biomass (Thailand); Penthamkeerati, Patthra [Environmental Technology Unit, Department of Environmental Science, Kasetsart University, Bangkok (Thailand); Reungsang, Alissara [Research Group for Development of Microbial Hydrogen Production Process from Biomass (Thailand); Department of Biotechnology, Khon Kaen University, Khon Kaen, Bangkok (Thailand); Lo, Yung-Chung [Department of Chemical Engineering, National Cheng Kung University, Tainan (China); Lu, Wei-Bin [Department of Cosmetic Science, Chung Hwa University of Medical Technology, Tainan (China); Chang, Jo-Shu [Department of Chemical Engineering, National Cheng Kung University, Tainan (China); Sustainable Environment Research Center, National Cheng Kung University, Tainan (China)

    2009-09-15

    Production of biohydrogen from dark fermentation is an interesting alternative to producing renewable fuels because of its low cost and various usable substrates. Cellulosic content in plentiful bagasse residue is an economically feasible feedstock for biohydrogen production. A statistical experimental design was applied to identify the optimal condition for biohydrogen production from enzymatically hydrolyzed bagasse with 60-min preheated seed sludge. The bagasse substrate was first heated at 100 C for 2 h and was then hydrolyzed with cellulase. Culture of the pretreated bagasse at 55 C provided a higher H{sub 2} production performance than that obtained from cultures at 45 C, 65 C, 35 C and 25 C. On the other hand, the culture at pH 5 resulted in higher H{sub 2} production than the cultures at pH 6, pH 4 and pH 7. The optimal culture condition for the hydrogen production rate was around 56.5 C and pH 5.2, which was identified using response surface methodology. Moreover, the pretreatment of bagasse under alkaline conditions gave a thirteen-fold increase in H{sub 2} production yield when compared with that from preheatment under neutral condition. (author)

  9. Effects of preceding endoscopic mucosal resection on the efficacy and safety of radiofrequency ablation for treatment of Barrett's esophagus: results from the United States Radiofrequency Ablation Registry.

    Science.gov (United States)

    Li, N; Pasricha, S; Bulsiewicz, W J; Pruitt, R E; Komanduri, S; Wolfsen, H C; Chmielewski, G W; Corbett, F S; Chang, K J; Shaheen, N J

    2016-08-01

    The effects of preceding endoscopic mucosal resection (EMR) on the efficacy and safety of radiofrequency ablation (RFA) for treatment of nodular Barrett's esophagus (BE) is poorly understood. Prior studies have been limited to case series from individual tertiary care centers. We report the results of a large, multicenter registry. We assessed the effects of preceding EMR on the efficacy and safety of RFA for nodular BE with advanced neoplasia (high-grade dysplasia or intramucosal carcinoma) using the US RFA Registry, a nationwide study of BE patients treated with RFA at 148 institutions. Safety outcomes included stricture, gastrointestinal bleeding, and hospitalization. Efficacy outcomes included complete eradication of intestinal metaplasia (CEIM), complete eradication of dysplasia (CED), and number of RFA treatments needed to achieve CEIM. Analyses comparing patients with EMR before RFA to patients undergoing RFA alone were performed with Student's t-test, Chi-square test, logistic regression, and Kaplan-Meier analysis. Four hundred six patients were treated with EMR before RFA for nodular BE, and 857 patients were treated with RFA only for non-nodular BE. The total complication rates were 8.4% in the EMR-before-RFA group and 7.2% in the RFA-only group (P = 0.48). Rates of stricture, bleeding, and hospitalization were not significantly different between patients treated with EMR before RFA and patients treated with RFA alone. CEIM was achieved in 84% of patients treated with EMR before RFA, and 84% of patients treated with RFA only (P = 0.96). CED was achieved in 94% and 92% of patients in EMR-before-RFA and RFA-only group, respectively (P = 0.17). Durability of eradication did not differ between the groups. EMR-before-RFA for nodular BE with advanced neoplasia is effective and safe. The preceding EMR neither diminished the efficacy nor increased complication rate of RFA treatment compared to patients with advanced neoplasia who had RFA with no preceding EMR

  10. Performance and emission evaluation of a CI engine fueled with preheated raw rapeseed oil (RRO)-diesel blends

    Energy Technology Data Exchange (ETDEWEB)

    Hazar, Hanbey [Department of Automotive, Faculty of Technical Education, Firat University, Elazig 23119 (Turkey); Aydin, Hueseyin [Department of Automotive, Faculty of Technical Education, Batman University, Batman 72060 (Turkey)

    2010-03-15

    Many studies are still being carried out to find out surplus information about how vegetable based oils can efficiently be used in compression ignition engines. Raw rapeseed oil (RRO) was used as blended with diesel fuel (DF) by 50% oil-50% diesel fuel in volume (O50) also as blended with diesel fuel by 20% oil-80% diesel fuel in volume (O20). The test fuels were used in a single cylinder, four stroke, naturally aspirated, direct injection compression ignition engine. The effects of fuel preheating to 100 C on the engine performance and emission characteristics of a CI engine fueled with rapeseed oil diesel blends were clarified. Results showed that preheating of RRO was lowered RRO's viscosity and provided smooth fuel flow Heating is necessary for smooth flow and to avoid fuel filter clogging. It can be achieved by heating RRO to 100 C. It can also be concluded that preheating of the fuel have some positive effects on engine performance and emissions when operating with vegetable oil. (author)

  11. 燃料稀释对传统型和高预热空气稀释型燃烧炉性能的影响的数值研究%Numerical Investigation of Fuel Dilution Effects on the Performance of the Conventional and the Highly Preheated and Diluted Air Combustion Furnaces

    Institute of Scientific and Technical Information of China (English)

    Kiomars Abbasi Khazaei; Ali Asghar Hamidi; Masoud Rahimi

    2009-01-01

    This numerical study investigates the effects of using a diluted fuel (50% natural gas and 50% N_2) in an industrial furnace under several cases of conventional combustion (air with 21% O_2 at 300 and 1273 K) and the highly preheated and diluted air (1273 K with 10% O_2 and 90% N_2) combustion (HPDAC) conditions using an in-house computer program. It was found that by applying a combined diluted fuel and oxidant instead of their un-combined and/or undiluted states, the best condition is obtained for the establishment of HPDAC's main unique features. These features are low mean and maximum gas temperature and high radiation/total heat transfer to gas and tubes; as well as more uniformity of theirs distributions which results in decrease in NO_x pollutant formation and increase in furnace efficiency or energy saving. Moreover, a variety of chemical flame shape, the process fluid and tubes walls temperatures profiles, the required regenerator efficiency and finally the concentration and velocity patterns have been also qualitatively/quantitatively studied.

  12. Minimisation of the thermal load of the ablation in high-speed laser corneal refractive surgery: the 'intelligent thermal effect control' of the AMARIS platform

    Science.gov (United States)

    Brunsmann, Ulrich; Sauer, Udo; Dressler, Katharina; Triefenbach, Nico; Arba Mosquera, Samuel

    2010-03-01

    The purpose of this work was to evaluate the extent that minimisation of the thermal load of the ablation in high-speed laser corneal refractive surgery is possible. To do this, thermal load from ablations onto flat PMMA plates was recorded with an infrared thermal camera and analysed for different flying-spot sorting algorithms (from pure randomised to 36 Hz local frequency) using a 500 Hz laser system with a fluence of 500 mJ/cm2, and aspheric ablation profiles. Each ablation configuration was repeated three times. Thermal load valid for corneal ablations was modelled based upon the results from ablations onto flat PMMA plates. It was found that the thermal load of ablations onto flat PMMA plates declines steadily when the allowed local frequency decreases or when the diameter of the blocked area increases. With this laser system, a local frequency of 39 Hz dynamically controlled over a diameter of 3.865 mm seems to be optimal for avoiding corneal collagen denaturation with minimum compromise on treatment duration. Peak temperature changes of 48°C in PMMA (16°C equivalent cornea) using pure randomised flying-spot sorting algorithms were reduced to 27°C in PMMA (9°C equivalent cornea) using 36 Hz local frequency over a blocked diameter of 4.25 mm. Average temperature changes of 15°C in PMMA (5°C equivalent cornea) using pure randomised flying-spot sorting algorithms were reduced to 7°C in PMMA (2°C equivalent cornea) using 36 Hz local frequency over a blocked diameter of 4.25 mm. Hence, minimisation of the thermal load of the ablation in high-speed laser corneal refractive surgery seems feasible using 'Intelligent Thermal Effect Control'. Clinical evaluations of human eyes are needed to confirm the preliminary simulated results presented here.

  13. Effect of eyestalk ablation on moulting and growth in the penaeid shrimp Metapenaeus monoceros (Fabricius, 1798)

    Digital Repository Service at National Institute of Oceanography (India)

    Venkitaraman, P.R.; Jayalakshmy, K.V.; Balasubramanian, T.

    weight was achieved and stored in the desicators for further analysis. Eyestalk ablation In the present study, eyestalks were removed using sterile surgical blades by which mortality was reduced to the minimum. Prawns in the inter-moult stage were....001). 5 Moulting Data on moulting frequency was subjected to Tuckey’s (Federer, 1967) test of additivity for two way classification to determine the optimal value of p in the transformation Y...

  14. Comparison of Theoretical and Experimental Values for the Effective Heat of Ablation of Ammonium Chloride

    Science.gov (United States)

    Welker, Jean E.

    1960-01-01

    Thermodynamic properties of ammonium chloride have been obtained and applied to a theoretical analysis of the shielding mechanism which reduces the rate of heat transfer to a body when ablation takes place at the surface. The analysis has considered the mechanism as one in which the material sublimes directly from the solid to the vapor phase. The results of the computation are compared with the experimental results obtained from the Langley 700-kilowatt arc jet.

  15. Transient effects in unstable ablation fronts and mixing layers in HEDP

    Science.gov (United States)

    Clarisse, J.-M.; Gauthier, S.; Dastugue, L.; Vallet, A.; Schneider, N.

    2016-07-01

    We report results obtained for two elementary unstable flow configurations relevant to high energy density physics: the ablation front instability and the Rayleigh-Taylor -instability induced mixing layer. These two flows are characterized by a transience of their perturbation dynamics. In the ablative flow case, this perturbation dynamics transience takes the form of finite-durations of successive linear-perturbation evolution phases until reaching regimes of decaying oscillations. This behaviour is observed in various regimes: weakly or strongly accelerated ablation fronts, irradiation asymmetries or initial external-surface defects, and is a result of the mean-flow unsteadiness and stretching. In the case of the Rayleigh-Taylor-instability induced mixing layer, perturbation dynamics transience manifests itself through the extinction of turbulence and mixing as the flow reaches a stable state made of two stably stratified layers of pure fluids separated by an unstratified mixing layer. A second feature, also due to compressibility, takes the form of an intense acoustic wave production, mainly localized in the heavy fluid. Finally, we point out that a systematic short-term linear-perturbation dynamics analysis should be undertaken within the framework of non-normal stability theory.

  16. The effectiveness of external beam radiotherapy for acromegaly is not affected by previous pituitary ablative treatments

    Energy Technology Data Exchange (ETDEWEB)

    Reed, P.I.; Joplin, G.F. (Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London (UK)); Speirs, C.J. (Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London (UK)); Morrison, R. (Department of Radiotherapy, Royal Postgraduate Medical School, Hammersmith Hospital, London (UK)); Aber, V. (Department of Medical Physics, Royal Postgraduate Medical School, Hammersmith Hospital, London (UK))

    1990-01-01

    Thirty-three acromegalic patients were treated with radiotherapy and followed up for at least 3 years (mean 6 years, range 3 to 12). Seventeen had not had previous pituitary ablative therapy and 16 had. The mean GH level for these two groups before radiotherapy was comparable at 98 and 119 mlU/l. The observed frequency of reaching <10 mlU/L was 53% and 75% of patients in the two groups, respectively, the mean observed falls in growth hormone level were 81 and 85% of the initial level, and the calculated exponential decline rate of GH level was 72 and 52% per fyear. Considering all 35 patients, requirement for pituitary hormone replacement therapy increased from 15 patients before radiotherapy to 20 after radiotherapy, being mostly those who had had prior ablative therapies. There were no complications attributable to the radiotherapy treatment. It appears that radiotherapy is equally efficacious whether a prior unsuccessful ablative procedure had been used or not. (author).

  17. Effective absorption coefficient measurements in PMMA and PTFE by clean ablation process with a coherent VUV source at 125 nm

    Science.gov (United States)

    Riedel, D.; Castex, M. C.

    First measurements of effective absorption coefficient and penetration depth are given here from the ablation of poly-methylmethacrylate (PMMA) and poly-tetrafluoroethylene (PTFE) samples at 125 nm ( 10 eV). The coherent VUV source used which provides smooth, efficient and clean etched areas, is briefly described. Experimental curves of etch depth as a function of the number of laser shots and etch rate as a function of energy density are obtained and compared with previous works performed at 157 nm (F2 laser) and 193 nm (ArF laser). Experimental results are described with a Beer-Lambert absorption law and discussed.

  18. Effect of laser ablation mode on corneal ablation depths with different corneal zone%准分子激光切削模式对角膜不同区域切削深度影响研究

    Institute of Scientific and Technical Information of China (English)

    郑秀云; 雷玉琳; 侯杰; 党光福

    2012-01-01

    目的 探讨准分子激光切削模式对中高度近视患者角膜不同区域切削深度的影响.方法 前瞻性研究.对65例(108只眼)近视及近视散光患者行飞秒激光制瓣的LASIK手术,其中A组39例(59只眼)使用Visx Star S4的普通切削模式,B组30例(49只眼)使用Zeiss Mel 80的Topography 切削模式.手术前及手术后1周、1个月采用眼前节OCT对角膜不同区域的角膜厚度进行测量,以手术前后厚度差值作为实际切削深度.结果 手术后A、B两组角膜中央区域实际切削深度均较术前预计值增加,两组的差值差异无统计学意义(t1w=-0.355,R1w=0.723;t1m=-1.306,P1m=0.303).术后1周角膜5~6 mm区域,B组的平均切削深度略高于A组(t=-3.974,P=0.000).角膜上方、颞上方以及鼻上方三个扇形区域总的平均切削深度明显高于颞下方、下方、鼻下方的总平均切削深度(A组:t2-5mm=3.883,P2-5mm=0.000;t5-6mm=2.898,P5-6mm=0.005.B组:t2-5mm=5.168,P2-5mm=0.000;t5-6mm=3.516,P5-6mm=0.001).颞侧的切削深度明显高于鼻侧(A组:t2-5mm=23.456,P2-5mm=0.000;t5-6mm=22.163,P5-6mm=0.000.B组:t2-5mm=13.326,P2-5mm=-0.000;t5-6mm=25.397,P5-6mm=0.000).结论 准分子激光角膜屈光手术不同切削模式对角膜非中央区域的组织切削深度有所不同,同一切削模式对角膜不同区域的切削深度也不同,对患者实施手术时,需要对各种影响切削深度的因素进行综合考虑.%Objective To investigate the effect on comeal ablation depth with different corneal zones in myopic eyes using different laser ablation mode. Methods One hundred and eight myopic eyes of 65 subjects (Group A:59 eyes with Visx Star S4,Group B:49 eyes with Zeiss Mel 80)having LASIK were enrolled in this prospective study.Corneal flap was making by femtosecond laser.The ablation depth of the corneal for different corneal zones were measured with OCT (Optovue,USA) preoperatively and postoperatively. Results Actual central corneal ablation

  19. Improved design and operation of crude furnace air preheater for cold climates

    Energy Technology Data Exchange (ETDEWEB)

    Gollpudi, B. [Bantrel Co. (Canada); Nichols, D. [Husky Energy (Canada)

    2011-07-01

    In the heavy oil industry, air preheaters are used to heat combustion air with hot flue gas. Flue gas contains significant amounts of sulphur oxides which can result in acid dew point corrosion on the flue gas side. The air preheater metal has therefore to be kept at a temperature higher than this dew point to provide trouble free operation. This paper relates a case of dew point corrosion damage in an air preheater and the design modifications made to solve the problem. The case studied took place at the crude furnace at Husky Energy's Lloydminster Upgrader where a plate exchanger air preheater was installed in 2007 and corrosion was noticed in 2009. It was found that hot air recirculation helps in maintaining a sufficiently high temperature and that the ducting design avoids dead zones. This paper showed that improved design can help to prevent damage occurring in the air preheater.

  20. Molten salt parabolic trough system with synthetic oil preheating

    Science.gov (United States)

    Yuasa, Minoru; Hino, Koichi

    2017-06-01

    Molten salt parabolic trough system (MSPT), which can heat the heat transfer fluid (HTF) to 550 °C has a better performance than a synthetic oil parabolic trough system (SOPT), which can heat the HTF to 400 °C or less. The utilization of HTF at higher temperature in the parabolic trough system is able to realize the design of a smaller size of storage tank and higher heat to electricity conversion efficiency. However, with MSPT there is a great amount of heat loss at night so it is necessary to circulate the HTF at a high temperature of about 290 °C in order to prevent solidification. A new MSPT concept with SOPT preheating (MSSOPT) has been developed to reduce the heat loss at night. In this paper, the MSSOPT system, its performance by steady state analysis and annual performance analysis are introduced.

  1. 20 YEARS OF EXPERIENCE WITH SCRAP PREHEATING TECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Je. Apfel

    2015-01-01

    Full Text Available More and more countries worldwide implement new rules and regulations to improve energy efficiency and cut CO2 and hazardous off-gas emissions. Thus electric steelmakers need technology that keeps costs low, increases productivity and helps them adhere to environmental regulations. Decades of knowledge in preheating technology, and several different innovative applications which had been solution for many unique cases have been brought together and announced in 2010. EAF Quantum was designed as a pragmatic solution that meets requirements for high energy and cost efficiency, increased productivity and lowest emissions. Whether scrap, partly hot metal or direct-reduced iron (DRI is charged, EAF Quantum is the solution for highly productive electric steelmaking at extra low conversion costs.

  2. Pre-heating in the framework of massive gravity

    Directory of Open Access Journals (Sweden)

    Debaprasad Maity

    2016-09-01

    Full Text Available In this paper we propose a mechanism of natural pre-heating of our universe by introducing an inflaton field dependent mass term for the gravitational wave for a specific class of massive gravity theory. For any single field inflationary model, the inflaton must go through the oscillatory phase after the end of inflation. As has recently been pointed out, if the gravitational fluctuation has inflaton dependent mass term, there will be a resonant amplification of the amplitude of the gravitational wave during the oscillatory phase of inflaton. Because of this large enhancement of the amplitude of the gravitational wave due to parametric resonance, we show that universe can naturally go through the pre-reheated phase with minimally coupled matter field. Therefore, during the reheating phase, there is no need to introduce any arbitrary coupling between the matter field and the inflaton.

  3. Combination of bubble liposomes and high-intensity focused ultrasound (HIFU) enhanced antitumor effect by tumor ablation.

    Science.gov (United States)

    Hamano, Nobuhito; Negishi, Yoichi; Takatori, Kyohei; Endo-Takahashi, Yoko; Suzuki, Ryo; Maruyama, Kazuo; Niidome, Takuro; Aramaki, Yukihiko

    2014-01-01

    Ultrasound (US) is used in the clinical setting not only for diagnosis but also for therapy. As a therapeutic US technique, high-intensity focused ultrasound (HIFU) can be applied to treat cancer in a clinical setting. Microbubbles increased temperature and improved the low therapeutic efficiency under HIFU; however, microbubbles have room for improvement in size, stability, and targeting ability. To solve these issues, we reported that "Bubble liposomes" (BLs) containing the US imaging gas (perfluoropropane gas) liposomes were suitable for ultrasound imaging and gene delivery. In this study, we examined whether BLs and HIFU could enhance the ablation area of the tumor and the antitumor effect. First, we histologically analyzed the tumor after BLs and HIFU. The ablation area of the treatment of BLs and HIFU was broader than that of HIFU alone. Next, we monitored the temperature of the tumor, and examined the antitumor effect. The temperature increase with BLs and HIFU treatment was faster and higher than that with HIFU alone. Moreover, treatment with BLs and HIFU enhanced the antitumor effect, which was better than with HIFU alone. Thus, the combination of BLs and HIFU could be efficacious for cancer therapy.

  4. The Effect of Catheter Ablation on Left Atrial Size and Function for Patients with Atrial Fibrillation: An Updated Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Bin Xiong

    Full Text Available Catheter ablation (CA for atrial fibrillation (AF is now an important therapeutic modality for patients with AF. However, data regarding changes in left atrial (LA function after CA have indicated conflicting results depending on the AF types, follow-up period, and the analytical imaging tools. The objective of this review was to analyze the effect of CA on the LA size and function for patients with AF.We searched for studies regarding LA size and function pre- and post-ablation in PubMed, Embase, the Cochrane Library, and Web of Knowledge through May 2014. LA function was measured by LA ejective fraction (LAEF, LA active ejective fraction (LAAEF, or both. Total and subgroup analyses were implemented using Cochrane Review Manager Version 5.2. Weighted mean differences with 95% confidence intervals were used to express the results of continuous outcomes using fixed or random effect models. I2 was used to calculate heterogeneity. To assess publication bias, Egger's test and Begg's funnel plot were performed using Stata 12.0.Twenty-five studies (2040 enrolled patients were selected for this meta-analysis. The LA diameter (LAD, maximum LA volume, and minimal LA volume were significantly decreased post-ablation, as compared with those at a pre-ablation visit. Compared with the pre-ablation outcomes, we found no significant differences in LAEF/LAAEF at a post-ablation follow-up. Decreases in LA volume and LAEF remained significant post-ablation for paroxysmal AF (PAF; however, the LAEF was insignificant changes in persistent AF (PeAF. Heterogeneity was significant in spite which individual study was excluded. A publication bias was not found. In a meta-regression analysis, we did not find any factor that contributed to the heterogeneity.With CA, LA volumes and LAD were decreased significantly in patients with AF; LAEF was not significant changes in patients with PeAF but decreased in those with PAF.

  5. Effect of oblique incidence on silver nanomaterials fabricated in water via ultrafast laser ablation for photonics and explosives detection

    Energy Technology Data Exchange (ETDEWEB)

    Krishna Podagatlapalli, G. [Advanced Center of Research in High Energy Materials (ACRHEM), University of Hyderabad, Prof. C. R. Rao Road, Hyderabad 500046 (India); Hamad, Syed [School of Physics, University of Hyderabad, Prof. C. R. Rao Road, Hyderabad 500046 (India); Ahamad Mohiddon, Md. [Centre for Nanotechnology University of Hyderabad, Prof. C. R. Rao Road, Hyderabad 500046 (India); Venugopal Rao, S., E-mail: svrsp@uohyd.ernet.in [Advanced Center of Research in High Energy Materials (ACRHEM), University of Hyderabad, Prof. C. R. Rao Road, Hyderabad 500046 (India)

    2014-06-01

    Highlights: •Effect of non-zero angle of incidence on ps ablation of Ag investigated. •Ag colloids were evaluated by TEM, UV–vis absorption spectra and fs-DFWM. •30° incident angle provided Ag NPs of small size with higher yields. •FESEM, AFM, Raman data revealed the fabrication of Ag nanostructures. •Utility of Ag nanostructures surfaces for multiple SERS studies demonstrated. -- Abstract: Picosecond (ps) laser ablation of silver (Ag) substrate submerged in double distilled water was performed at 800 nm for different angles of incidence of 5°, 15°, 30° and 45°. Prepared colloidal solutions were characterized through transmission electron microscopy, UV absorption spectroscopy to explore their morphologies and surface plasmon resonance (SPR) properties. Third order nonlinear optical (NLO) characterization of colloids was performed using degenerate four wave mixing (DFWM) technique with ∼40 fs laser pulses at 800 nm and the NLO coefficients were obtained. Detailed analysis of the data obtained from colloidal solutions suggested that superior results in terms of yield, sizes of the NPs, SPR peak position were achieved for ablation performed at 30° incident angle. Surface enhanced Raman spectra (SERS) of Rhodamine 6G from nanostructured substrates were investigated using excitation wavelengths of 532 and 785 nm. In both the cases substrates prepared at 30° incident angle exhibited superior enhancement in the Raman signatures with a best enhancement factor achieved being >10{sup 8}. SERS of an explosive molecule 5-amino, 3-nitro, -1H-1,2,4-nitrozole (ANTA) was also demonstrated from these nanostructured substrates. Multiple usage of Ag nanostructures for SERS studies revealed that structures prepared at 30° incident angle provided superior performance amongst all.

  6. MR-guided Neurolytic Celiac Plexus Ablation: An Evaluation of Effect and Injection Spread Pattern in Cancer Patients with Celiac Tumor Infiltration

    Energy Technology Data Exchange (ETDEWEB)

    Akural, Etem [Helsinki University Central Hospital, Pain Clinic (Finland); Ojala, Risto O. [Oulu University Hospital, Department of Radiology (Finland); Jaervimaeki, Voitto [Oulu University Hospital, Department of Anesthesiology (Finland); Kariniemi, Juho; Tervonen, Osmo A.; Blanco Sequeiros, Roberto, E-mail: roberto.blanco@oulu.fi [Oulu University Hospital, Department of Radiology (Finland)

    2013-04-15

    ObjectiveThe purpose of this study was to evaluate the feasibility, the initial accuracy, and the effects of the MR-guided neurolytic celiac plexus ablation as a method to treat cancer-induced chronic abdominal pain. Thirteen celiac plexus ablations were performed for 12 patients. A 0.23-T open MRI scanner with optical navigation was used for procedural guidance. As an adjunct to the MR-guided needle positioning, the needle location was confirmed with saline injection and consequent MR imaging (STIR sequence). The spread of the ablative injection material (alcohol-lidocaine mix) was observed by repeating this sequence after the therapeutic injection. Pain scores from seven patients (eight ablations) were used to assess the therapy effect. MR guidance allowed adequate needle positioning and visualization of injection material in all cases. The rest pain scores significantly decreased from 4 (median) at baseline to 1 (median) at 2 weeks (p < 0.05). Average and worst pain experienced during the past week were significantly lower at the 2-week time point compared with the baseline (p < 0.05). However, the intervention did not result in reduction of opioid use at 2 weeks.MR guidance is an accurate and safe method for celiac plexus ablation with positive therapeutic effect.

  7. Cost effectiveness of endometrial ablation with the NovaSure® system versus other global ablation modalities and hysterectomy for treatment of abnormal uterine bleeding: US commercial and Medicaid payer perspectives

    Directory of Open Access Journals (Sweden)

    Miller JD

    2015-01-01

    Full Text Available Jeffrey D Miller,1 Gregory M Lenhart,1 Machaon M Bonafede,1 Cindy M Basinski,2 Andrea S Lukes,3 Kathleen A Troeger4 1Truven Health Analytics, Cambridge, MA, 2Basinski, LLC, Newburgh, IN, 3Carolina Women’s Research and Wellness Center, Durham, NC, 4Hologic, Inc, Marlborough, MA, USA Objectives: Abnormal uterine bleeding (AUB interferes with physical, emotional, and social well-being, impacting the quality of life of more than 10 million women in the USA. Hysterectomy, the most common surgical treatment of AUB, has significant morbidity, low mortality, long recovery, and high associated health care costs. Global endometrial ablation (GEA provides a surgical alternative with reduced morbidity, cost, and recovery time. The NovaSure® system utilizes unique radiofrequency impedance-based GEA technology. This study evaluated cost effectiveness of AUB treatment with NovaSure ablation versus other GEA modalities and versus hysterectomy from the US commercial and Medicaid payer perspectives. Methods: A health state transition (semi-Markov model was developed using epidemiologic, clinical, and economic data from commercial and Medicaid claims database analyses, supplemented by published literature. Three hypothetical cohorts of women receiving AUB interventions were simulated over 1-, 3-, and 5-year horizons to evaluate clinical and economic outcomes for NovaSure, other GEA modalities, and hysterectomy. Results: Model analyses show lower costs for NovaSure-treated patients than for those treated with other GEA modalities or hysterectomy over all time frames under commercial payer and Medicaid perspectives. By Year 3, cost savings versus other GEA were $930 (commercial and $3,000 (Medicaid; cost savings versus hysterectomy were $6,500 (commercial and $8,900 (Medicaid. Coinciding with a 43%–71% reduction in need for re-ablation, there were 69%–88% fewer intervention/reintervention complications for NovaSure-treated patients versus other GEA modalities

  8. The effects of laser repetition rate on femtosecond laser ablation of dry bone: a thermal and LIBS study.

    Science.gov (United States)

    Gill, Ruby K; Smith, Zachary J; Lee, Changwon; Wachsmann-Hogiu, Sebastian

    2016-01-01

    The aim of this study is to understand the effect of varying laser repetition rate on thermal energy accumulation and dissipation as well as femtosecond Laser Induced Breakdown Spectroscopy (fsLIBS) signals, which may help create the framework for clinical translation of femtosecond lasers for surgical procedures. We study the effect of repetition rates on ablation widths, sample temperature, and LIBS signal of bone. SEM images were acquired to quantify the morphology of the ablated volume and fsLIBS was performed to characterize changes in signal intensity and background. We also report for the first time experimentally measured temperature distributions of bone irradiated with femtosecond lasers at repetition rates below and above carbonization conditions. While high repetition rates would allow for faster cutting, heat accumulation exceeds heat dissipation and results in carbonization of the sample. At repetition rates where carbonization occurs, the sample temperature increases to a level that is well above the threshold for irreversible cellular damage. These results highlight the importance of the need for careful selection of the repetition rate for a femtosecond laser surgery procedure to minimize the extent of thermal damage to surrounding tissues and prevent misclassification of tissue by fsLIBS analysis.

  9. Effect of pretreatment with aspirin and ticlopidine on the change of platelet aggregability after radiofrequency catheter ablation

    Institute of Scientific and Technical Information of China (English)

    王利宏; 陈君柱; 郑良荣; 陶谦民

    2002-01-01

    Eighty-two patients with supraventricular tachycardia undergoing radiofrequency catheter ablation (RFCA) were studied to observe the inhibition effect of aspirin and ticlopidine on platelet aggregability(PAG) and thromboxane B2(TXB2) of the blood samples.Patients were divided into aspirin group A.ticlopidine group B.aspirin+ticlopidine group C and control group D.PAG and TXB2 were increased clearly after RFCA in all groups(P<0.001).Treatment with aspirin or ticlopidine before operation could reduce the patelet aggregability caused by RFCA and the joint effect of two drugs(change rate of group A:52.51±12.51%;group B:54.78±11.27%;group C:30.51±10.59%;group D:91.75±21.43%;(P<0.05)was studied .The much decreased platelet aggregability after antiplatelet therapy was evidence of the potential benefit of the treatment in preventing thromboembolism after ablation.Pretreatment with aspirin and ticlopidine together is a good way to decrease palateler aggregability after RFCA.

  10. Effect of pretreatment with aspirin and ticlopidine on the change of platelet aggregability after radiofrequency catheter ablation

    Institute of Scientific and Technical Information of China (English)

    王利宏; 陈君柱; 郑良荣; 陶谦民

    2002-01-01

    Eighty-two patients with supraventricular tachycardia undergoing radi o frequency catheter ablation (RFCA) were studied to observe the inhibition effect of aspirin and ticlopidine on platelet aggregability (PAG) and thromboxane B2 (T XB2) of the blood samples. Patients were divided into aspirin group A, ticlopi di ne group B, aspirin+ticlopidine group C and control group D. PAG and TXB2 were i ncreased clearly after RFCA in all groups (P<0.001). Treatment with aspirin or t iclopidine before operation could reduce the platelet aggregability caused by RF CA and the joint effect of two drugs(change rate of group A:52.51±12.51%; group B:54.78±11.27%;group C: 30.51±10.59%;group D:91.75±21.43%; P<0.05)was st udie d. The much decreased platelet aggregability after antiplatelet therapy was evid ence of the potential benefit of the treatment in preventing thromboembolism aft er ablation. Pretreatment with aspirin and ticlopidine together is a good way to decrease palatelet aggregability after RFCA.

  11. Enhanced tumor localization and retention of chlorin e6 in cationic nanolipoplexes potentiate the tumor ablation effects of photodynamic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Gayong; Lee, Sangbin; Kim, Chan-Wha [School of Life Sciences and Biotechnology, Korea University, Seoul (Korea, Republic of); Kim, Young Bong [Department of Animal Biotechnology, Konkuk University, Seoul (Korea, Republic of); Oh, Yu-Kyoung, E-mail: ohyk@snu.ac.kr [College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul (Korea, Republic of)

    2011-09-07

    Here we report the tumor ablation effects of the negatively charged photosensitizer chlorin e6 (Ce6) in nanocomplexes. Ce6 was complexed to cationic 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine-based liposomes, forming cationic nanolipoplexes. The loading efficiency of Ce6 to cationic nanolipoplexes was greater than 90%. The degree of enhancement of cellular uptake of Ce6 by treatment in cationic nanolipoplexes increased with the concentration of Ce6, showing 18.3-fold higher uptake than free Ce6 at 15 {mu}M. Molecular imaging revealed the preferential distribution and retention of Ce6 in SCC7 tumor tissues after intravenous administration of Ce6 in cationic nanolipoplexes. Moreover, localized illumination of mice receiving Ce6 in cationic nanolipoplexes resulted in the formation of thick scabs over tumor regions, and complete ablation of tumors after scab detachment. In contrast, continuous growth of tumors was observed in the group treated with free Ce6. Our results suggest that the cationic nanolipoplexes of Ce6 improve the therapeutic effects of photodynamic cancer therapy as compared to free Ce6.

  12. Effect of inter-pulse delay time on production and size properties of colloidal nanoparticles prepared by collinear double-pulse laser ablation in liquid

    Science.gov (United States)

    Fattahi, Behzad; Mahdieh, Mohammah Hossein

    2016-08-01

    The influence of inter-pulse delay times (0-20 ns) between two collinear sequential nanosecond pulses on the production and size properties (mean size and size distribution) of colloidal nanoparticles prepared by pulsed laser ablation of a silver target in a distilled water medium has been studied. Various laser fluences at different inter-pulse delay times between two collinear pulses were used. Furthermore, for a better understanding of the effect of the double-pulse and single-pulse mode, experiments were performed. The characterization of the synthesized colloidal nanoparticles was investigated using scanning electron microscopy (SEM) and UV-vis absorption spectroscopy. Our results showed that 5 ns time-delayed double-pulse laser ablation results in the production of nanoparticles with the highest concentration among the other time-delayed ablation experiments and even more than single-pulse-mode experiments. It also found that using a double-pulse approach with inter-pulse delay times in the range of 0-20 ns leads to the production of nanoparticles with smaller mean sizes and narrower size distributions in comparison to single-pulse-mode laser ablation. The effect of time overlapping between two pulses in the case of double-pulse ablation was analyzed.

  13. PLASMA-OXYGEN INTERACTION DURING THIN FILMS DEPOSITION BY LASER ABLATION: DETERMINATION OF THE INTERACTION PRESSURE THRESHOLD AND EFFECT ON THE THIN FILMS PROPERTIESE

    Directory of Open Access Journals (Sweden)

    S. Lafane

    2015-07-01

    Full Text Available In this contribution we study the effect of the oxygen pressure on the plasma dynamics during the ablation of oxides materials into an oxygen gas. The study was done using fast imaging and ion probe techniques. Both techniques revealed that a threshold oxygen pressure is needed to initiate the plume oxygen interaction. This threshold oxygen pressure depends on the ablated material. A clear effect of this threshold pressure on the structural and phase composition of the deposited thin films is shown.

  14. Effects of bone marrow ablation on compartmental prostaglandin synthesis by mononuclear phagocytes

    Energy Technology Data Exchange (ETDEWEB)

    Volkman, A.; Shibata, Y.; Dempsey, W.; Morahan, P.S.

    1988-01-01

    Mononuclear phagocyte functions were studied in mice selectively deprived of bone marrow and rendered profoundly monocytopenic by the administration of the bone seeking isotope, 89Sr. Characteristics of such mice include severe impairment of monocyte-M phi elicitation, ablation of C. parvum induction of PGSM but the persistence of resident peritoneal and pulmonary alveolar M phi populations; splenic M phi increase in number concomitantly with splenic hemopoiesis. Studies on compartmental regulation in this model suggest that the capacity of splenic M phi to synthesize and release PGE2 is dependent upon a function of the bone marrow and is not wholly determined by the local environment. The relationship of blood monocytes to PGSM is uncertain. In contrast to splenic M phi, the capacity of resident peritoneal M phi for eicosanoid synthesis appears to be independent of bone marrow function. Monocyte influx, moreover, does not appear necessary for the maintenance of the resident peritoneal and alveolar M phi populations. We do not yet know whether bone marrow ablation destroys a migratory precursor of PGSM or the source of a crucial regulatory agent. In conclusion, the observations discussed show that prostaglandin metabolism within the spleen is subject to extracompartmental influence. It is clearly important to determine the regulatory characteristics of individual M phi compartments and generalizations about functional properties of mononuclear phagocytes should be made with circumspection. 19 references.

  15. Effect of Radiofrequency Catheter Ablation on Quality of Life in Patients with Wolff-Parkinson-White Syndrome

    Directory of Open Access Journals (Sweden)

    Shokhrukh Erkaboev

    2015-09-01

    Full Text Available Wolff-Parkinson-White (WPW syndrome is one of several disorders of the conduction system of the heart that are commonly referred to as pre-excitation syndromes. As the syndrome significantly reduces the patients’ quality of life (QoL, the purpose of the current study was to compare QoL scores in patients with WPW syndrome before and after a radiofrequency catheter ablation (RFA procedure. To assess the patients’ QoL, the MOS 36-Item Short-Form Health Survey was used. Immediate and long-term outcomes of radiofrequency catheter ablation were analyzed in 60 patients diagnosed with WPW syndrome, 41(68.3% men and 19(31.7% women. As compared with the controls (28 apparently healthy persons, patients with WPW syndrome before RFA experienced significant reduction in both physical and mental health components. RFA was found effective in 93.3% of patients with WPW syndrome. At 3 months after RFA, patients showed significant improvement in both physical (13.5% and mental (17.2% health components; at 12 months, QoL parameters reached those of the controls.

  16. Comparison of the effectiveness of nonablative fractional laser versus ablative fractional laser in thyroidectomy scar prevention: A pilot study.

    Science.gov (United States)

    Kim, Hei Sung; Lee, Ji Hae; Park, Young Min; Lee, Jun Young

    2012-04-01

    A scar is a mark that remains after the healing of a wound or other morbid processes. In the past, treatment was mainly focused on severe scarring, such as the hypertrophic and burn scars. However, scars from relatively minor wounds can also be stressful. The site of an open thyroidectomy is the anterior neck, a prominently exposed part of the body, where postoperative scarring can cause patients distress. The cosmetic outcome of the scar after thyroidectomy is of particular importance to women, who constitute the majority of patients with thyroid disease. Active prevention is more likely to yield better cosmetic results and would require fewer treatment sessions and less expense than scar revision procedures. Many interventions have been proposed, but there is yet no universal consensus on optimal treatment. Recently, focus has been made on 'laser scar prevention', where various types of lasers have been used to improve the appearance of scars. The purpose of this study was to improve the appearance of scars, by laser intervention of the wound healing process. In this pilot study, we comparatively examined the effect of non-ablative 1550-nm fractional Er: glass laser and ablative 2940-nm fractional Er: YAG laser on fresh surgical scars of patients with Fitzpatrick skin type III-IV.

  17. Size properties of colloidal nanoparticles produced by nanosecond pulsed laser ablation and studying the effects of liquid medium and laser fluence

    Energy Technology Data Exchange (ETDEWEB)

    Mahdieh, Mohammad Hossein, E-mail: mahdm@iust.ac.ir; Fattahi, Behzad

    2015-02-28

    Highlights: • Colloidal aluminum- and titanium-based nanoparticles fabricated by laser ablation. • Various liquid environments and laser fluences were applied as variable parameters. • Physical characteristics of liquid medium influence ablation process and nanoparticle formation. • Size properties of prepared nanoparticles depend on liquid medium and laser fluence. • Ablation of both metals in ethanol results in nanoparticles with smaller size. - Abstract: In this paper, pulsed laser ablation method was used for synthesis of colloidal nanoparticles of aluminum and titanium targets in distilled water, ethanol, and acetone as liquid environments. Ultraviolet–visible (UV–vis) absorption spectrophotometer and scanning electron microscope (SEM) were used for characterization of produced nanoparticles. Using image processing technique and analyzing the SEM images, nanoparticles’ mean size and size distribution were achieved. The results show that liquid medium has strong effect on size properties of produced nanoparticles. From the results, it was found that ablation of both metal targets in ethanol medium leads to formation of smaller size nanoparticles with narrower size distributions. The influence of laser fluence was also investigated. According to the results, higher laser fluence produces larger mean size nanoparticles with broader size distribution.

  18. Hepatic Thermal Ablation: Effect of Device and Heating Parameters on Local Tissue Reactions and Distant Tumor Growth.

    Science.gov (United States)

    Velez, Erik; Goldberg, S Nahum; Kumar, Gaurav; Wang, Yuanguo; Gourevitch, Svetlana; Sosna, Jacob; Moon, Tyler; Brace, Christopher L; Ahmed, Muneeb

    2016-12-01

    Purpose To determine whether variable hepatic microwave ablation (MWA) can induce local inflammation and distant pro-oncogenic effects compared with hepatic radiofrequency ablation (RFA) in an animal model. Materials and Methods In this institutional Animal Care and Use Committee-approved study, F344 rats (150 gm, n = 96) with subcutaneous R3230 breast adenocarcinoma tumors had normal non-tumor-bearing liver treated with RFA (70°C × 5 minutes), rapid higher-power MWA (20 W × 15 seconds), slower lower-power MWA (5 W × 2 minutes), or a sham procedure (needle placement without energy) and were sacrificed at 6 hours to 7 days (four time points; six animals per arm per time point). Ablation settings produced 11.4 mm ± 0.8 of coagulation for all groups. Distant tumor growth rates were determined to 7 days after treatment. Liver heat shock protein (HSP) 70 levels (at 72 hours) and macrophages (CD68 at 7 days), tumor proliferative indexes (Ki-67 and CD34 at 7 days), and serum and tissue levels of interleukin 6 (IL-6) at 6 hours, hepatocyte growth factor (HGF) at 72 hours, and vascular endothelial growth factor (VEGF) at 72 hours after ablation were assessed. All data were expressed as means ± standard deviations and were compared by using two-tailed t tests and analysis of variance for selected group comparisons. Linear regression analysis of tumor growth curves was used to determine pre- and posttreatment growth curves on a per-tumor basis. Results At 7 days, hepatic ablations with 5-W MWA and RFA increased distant tumor size compared with 20-W MWA and the sham procedure (5-W MWA: 16.3 mm ± 1.1 and RFA: 16.3 mm ± 0.9 vs sham: 13.6 mm ± 1.3, P < .01, and 20-W MWA: 14.6 mm ± 0.9, P < .05). RFA and 5-W MWA increased postablation tumor growth rates compared with the 20-W MWA and sham arms (preablation growth rates range for all arms: 0.60-0.64 mm/d; postablation: RFA: 0.91 mm/d ± 0.11, 5-W MWA: 0.91 mm/d ± 0.14, P < .01 vs pretreatment; 20-W MWA: 0.69 mm/d ± 0

  19. Analysis of iodinated contrast delivered during thermal ablation: is material trapped in the ablation zone?

    Science.gov (United States)

    Wu, Po-hung; Brace, Chris L.

    2016-08-01

    Intra-procedural contrast-enhanced CT (CECT) has been proposed to evaluate treatment efficacy of thermal ablation. We hypothesized that contrast material delivered concurrently with thermal ablation may become trapped in the ablation zone, and set out to determine whether such an effect would impact ablation visualization. CECT images were acquired during microwave ablation in normal porcine liver with: (A) normal blood perfusion and no iodinated contrast, (B) normal perfusion and iodinated contrast infusion or (C) no blood perfusion and residual iodinated contrast. Changes in CT attenuation were analyzed from before, during and after ablation to evaluate whether contrast was trapped inside of the ablation zone. Visualization was compared between groups using post-ablation contrast-to-noise ratio (CNR). Attenuation gradients were calculated at the ablation boundary and background to quantitate ablation conspicuity. In Group A, attenuation decreased during ablation due to thermal expansion of tissue water and water vaporization. The ablation zone was difficult to visualize (CNR  =  1.57  ±  0.73, boundary gradient  =  0.7  ±  0.4 HU mm-1), leading to ablation diameter underestimation compared to gross pathology. Group B ablations saw attenuation increase, suggesting that iodine was trapped inside the ablation zone. However, because the normally perfused liver increased even more, Group B ablations were more visible than Group A (CNR  =  2.04  ±  0.84, boundary gradient  =  6.3  ±  1.1 HU mm-1) and allowed accurate estimation of the ablation zone dimensions compared to gross pathology. Substantial water vaporization led to substantial attenuation changes in Group C, though the ablation zone boundary was not highly visible (boundary gradient  =  3.9  ±  1.1 HU mm-1). Our results demonstrate that despite iodinated contrast being trapped in the ablation zone, ablation visibility was

  20. Primordial black hole production during preheating in a chaotic inflationary model

    CERN Document Server

    Torres-Lomas, E

    2013-01-01

    In this paper we review the production of primordial black holes (PBHs) during preheating after a chaotic inflationary model. All relevant equations of motion are solved numerically in a modified version of HLattice, and we then calculate the mass variance to determine structure formation during preheating. It is found that production of PBHs can be a generic result of the model, even though the results seem to be sensitive to the values of the smoothing scale. We consider a constraint for overproduction of PBHs that could uncover some stress between inflation-preheating models and observations.

  1. Synergistic effect of heat-shock and UV-irradiation on mitosis and protein synthesis in G2-phase plasmodia of Physarum polycephalum Schw--reduction in UV-induced mitotic delay in a preheat-shocked system.

    Science.gov (United States)

    Kumar, P R; Nair, R V

    1991-04-01

    The synergistic effect of UV irradiation and heat-shock during the last 3 hr of G2 phase of the cell cycle in the plasmodia of P. polycephalum, in terms of mitotic delay and inhibition of protein synthesis, has been evaluated. The mitotic delay due to both perturbers coordinately increased closer to mitosis. Maximum mitotic delay was obtained in plasmodia heat-shocked after UV irradiation, indicating the presence in this system of either a heat-labile mitogenic substance which is comparatively less susceptible to UV or a substance which is made more susceptible to hyperthermia by UV. A protective role for heat-shock applied before irradiation has been observed in that, radiation-induced mitotic delay is significantly reduced in this combination. There was severe inhibition of translation in all the perturbed classes. Organelle level effects which are independent of major protein synthetic activities or different levels of heat-shock protein production could be the reason for the lack of correlation between percentage inhibition of general protein synthesis and the extent of mitotic delay with respect to the two double-perturbed systems.

  2. No effect of ablation of surfactant protein-D on acute cerebral infarction in mice

    DEFF Research Database (Denmark)

    Lambertsen, Kate Lykke; Østergaard, Kamilla; Clausen, Bettina Hjelm;

    2014-01-01

    -induced increase in TNF mRNA production one day after induction of ischemia; however the TNF response to the ischemic insult was affected at five days. SP-D mRNA was not detected in parenchymal brain cells in either naïve mice or in mice subjected to focal cerebral ischemia. However, SP-D mRNA was detected...... were comparable in SP-D KO and WT mice. CONCLUSIONS: SP-D synthesis in middle cerebral artery cells is consistent with SP-D conceivably leaking into the infarcted area and affecting local cytokine production. However, there was no SP-D synthesis in parenchymal brain cells and ablation of SP-D had...

  3. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers have no beneficial effect on ablation outcome in chronic persistent atrial fibrillation.

    Science.gov (United States)

    Zheng, Bin; Kang, Junping; Tian, Ying; Tang, Ribo; Long, Deyong; Yu, Ronghui; He, Hua; Zhang, Ming; Shi, Lisheng; Tao, Hailong; Liu, Xingpeng; Dong, Jianzeng; Ma, Changsheng

    2009-06-01

    Previous studies have shown that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) could reverse structural and electrical atria remodelling and decrease atrial fibrillation (AF) onset or recurrence. The aim of this retrospective study was to investigate whether ACEIs/ARBs had beneficial effects on ablation outcome of chronic persistent AF. This study included 139 patients with chronic persistent AF who underwent radiofrequency ablation in our centre. Patients were divided into an ACEIs/ARBs group or a non-ACEIs/ARBs group. During follow-up (14.6 +/- 8.9 months) after AF ablation, AF-free survival in the ACEIs/ARBs group was not significantly different from the non-ACEIs/ARBs group (P = 0.339). Univariate analysis showed that predictors for AF-free survival were AF history (HR, 1.064; 95% CI, 1.021-1.108; P = 0.003) and duration of chronic persistent AF (HR, 1.012; 95% CI, 1.005-1.019; P = 0.001). Multivariate analysis showed that predictors for AF-free survival were AF history (HR, 1.051; 95% CI, 1.004-1.101; P = 0.035) and duration of chronic persistent AF (HR, 1.012; 95% CI, 1.004-1.020; P = 0.004). ACEIs/ARBs therapy was not a predictor for AF-free survival neither in univariate nor multivariate analysis. In this observational study, no effect of ACEIs or ARBs was seen on the AF recurrence after ablation of chronic persistent AF.ACEIs/ARBs did not help to predict a better ablation outcome. Predictors for ablation outcome are AF history and duration of chronic persistent AF.

  4. Preheating after multifield inflation with nonminimal couplings, II: Resonance Structure

    CERN Document Server

    DeCross, Matthew P; Prabhu, Anirudh; Prescod-Weinstein, Chanda; Sfakianakis, Evangelos I

    2016-01-01

    This is the second in a series of papers on preheating in inflationary models comprised of multiple scalar fields coupled nonminimally to gravity. In this paper, we work in the rigid-spacetime approximation and consider field trajectories within the single-field attractor, which is a generic feature of these models. We construct the Floquet charts to find regions of parameter space in which particle production is efficient for both the adiabatic and isocurvature modes, and analyze the resonance structure using analytic and semi-analytic techniques. Particle production in the adiabatic direction is characterized by the existence of an asymptotic scaling solution at large values of the nonminimal couplings, $\\xi_I \\gg 1$, in which the dominant instability band arises in the long-wavelength limit, for comoving wavenumbers $k \\rightarrow 0$. However, the large-$\\xi_I$ regime is not reached until $\\xi_I \\geq {\\cal O} (100)$. In the intermediate regime, with $\\xi_I \\sim {\\cal O}(10)$, the resonance structure depend...

  5. The effects of liquid environments on the optical properties of linear carbon chains prepared by laser ablation generated plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Forte, G. [Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, 95125 Catania (Italy); D’Urso, L., E-mail: ldurso@unict.it [Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125 Catania (Italy); Fazio, E.; Patanè, S.; Neri, F. [Dipartimento di Fisica della Materia e Ingegneria Elettronica, Università di Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina (Italy); Puglisi, O.; Compagnini, G. [Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, 95125 Catania (Italy)

    2013-05-01

    Linear carbon chains (LCCs) were successfully produced by laser generated plasmas in different solvents starting from graphite rods. An identification of the prepared carbon structures was carried out from the analysis of the UV–vis spectra. Moreover, a systematic analysis of the DFT computed structural and electronic response of both polyynic and cumulenic model molecules, as a function of the solvents with different polarity, was carried out. The comparison between the calculated UV–vis spectra of polyynes series with the experimental ones clearly indicates that polyynes are the dominant species produced by the ablation process. The optical limiting properties were investigated by the Z-scan method, using a nanosecond pulsed laser. Both the different solvents and the carbon chain length distribution have a driving role in the nonlinear optical response. Hence, the effect of the solvent polarity and acidity was taken into account to explain the nature of the optical limiting behaviour.

  6. Adaptive preheating duration control for low-power ambient air quality sensor networks.

    Science.gov (United States)

    Baek, Yoonchul; Atiq, Mahin K; Kim, Hyung Seok

    2014-03-20

    Ceramic gas sensors used for measuring ambient air quality have features suitable for practical applications such as healthcare and air quality management, but have a major drawback-large power consumption to preheat the sensor for accurate measurements. In this paper; the adaptive preheating duration control (APC) method is proposed to reduce the power consumption of ambient air quality sensor networks. APC reduces the duration of unnecessary preheating, thereby alleviating power consumption. Furthermore, the APC can allow systems to meet user requirements such as accuracy and periodicity factor when detecting the concentration of a target gas. A performance evaluation of the power consumption of gas sensors is conducted with various user requirements and factors that affect the preheating duration of the gas sensor. This shows that the power consumption of the APC is lower than that of continuous power supply methods and constant power supply/cutoff methods.

  7. Adaptive Preheating Duration Control for Low-Power Ambient Air Quality Sensor Networks

    Directory of Open Access Journals (Sweden)

    Yoonchul Baek

    2014-03-01

    Full Text Available Ceramic gas sensors used for measuring ambient air quality have features suitable for practical applications such as healthcare and air quality management, but have a major drawback—large power consumption to preheat the sensor for accurate measurements. In this paper; the adaptive preheating duration control (APC method is proposed to reduce the power consumption of ambient air quality sensor networks. APC reduces the duration of unnecessary preheating, thereby alleviating power consumption. Furthermore, the APC can allow systems to meet user requirements such as accuracy and periodicity factor when detecting the concentration of a target gas. A performance evaluation of the power consumption of gas sensors is conducted with various user requirements and factors that affect the preheating duration of the gas sensor. This shows that the power consumption of the APC is lower than that of continuous power supply methods and constant power supply/cutoff methods.

  8. Ultrasound-guided alcohol neurolysis and radiofrequency ablation of painful stump neuroma: effective treatments for post-amputation pain

    Directory of Open Access Journals (Sweden)

    Zhang X

    2017-02-01

    Full Text Available Xin Zhang, Yongming Xu, Jin Zhou, Shaofeng Pu, Yingying Lv, Yueping Chen, Dongping Du Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Background: Post-amputation pain (PAP is highly prevalent after limb amputation, and stump neuromas play a key role in the generation of the pain. Presently, PAP refractory to medical management is frequently treated with minimally invasive procedures guided by ultrasound, such as alcohol neurolysis and radiofrequency ablation (RFA.Objective: To record the immediate and long-term efficacy of alcohol neurolysis and RFA. We first used alcohol neurolysis and then, when necessary, we performed RFA on PAP patients.Study design: Prospective case series.Setting: Pain management center.Methods: Thirteen subjects were treated with ultrasound-guided procedures.Results: All patients were treated with neurolysis using alcohol solutions guided by ultrasound. Seven (54% of 13 subjects achieved pain relief after 1–3 alcohol injection treatments. The remaining 6 subjects obtained pain relief after receiving 2 administrations of ultrasound-guided RFA. After a 6-month follow-up evaluation period, pain quantities were also assessed. Both stump pain (including intermittent sharp pain and continuous burning pain and phantom pain were relieved. The frequency of intermittent sharp pain was decreased, and no complications were noted during the observation.Conclusion: The use of ultrasound guidance for alcohol injection and RFA of painful stump neuromas is a simple, radiation-free, safe, and effective procedure that provides sustained pain relief in PAP patients. In this case series, RFA was found to be an effective alternative to alcohol injection. Keywords: post-amputation pain, neuroma, ultrasound-guided, alcohol neurolysis, radiofrequency ablation

  9. Cryoballoon Catheter Ablation in Atrial Fibrillation

    Directory of Open Access Journals (Sweden)

    Cevher Ozcan

    2011-01-01

    Full Text Available Pulmonary vein isolation with catheter ablation is an effective treatment in patients with symptomatic atrial fibrillation refractory or intolerant to antiarrhythmic medications. The cryoballoon catheter was recently approved for this procedure. In this paper, the basics of cryothermal energy ablation are reviewed including its ability of creating homogenous lesion formation, minimal destruction to surrounding vasculature, preserved tissue integrity, and lower risk of thrombus formation. Also summarized here are the publications describing the clinical experience with the cryoballoon catheter ablation in both paroxysmal and persistent atrial fibrillation, its safety and efficacy, and discussions on the technical aspect of the cryoballoon ablation procedure.

  10. The effect of pre-operative topical anaesthetic cream on the ablative width and coagulative depth of ablative fractional resurfacing laser.

    Science.gov (United States)

    Punyaratabandhu, Preawphan; Wanitphakdeedecha, Rungsima; Pattanaprichakul, Penvadee; Sitthinamsuwan, Panitta; Phothong, Weeranut; Eimpunth, Sasima; Lohsiriwat, Visnu; Manuskiatti, Woraphong

    2017-02-01

    Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. The objective of the study was to compare the ablative width (AW) and coagulative depth (CD) of AFR laser with and without pre-treatment with TAC. Four Thai females who underwent abdominoplasty were included in the study. The excised skin of each subject was divided into four areas. TAC (eutectic mixture of local anaesthesia; EMLA) with 1-h occlusion was applied only on the first and second areas. The first and third areas were treated with FCO2 at 15 mj and 5% density. The second and fourth areas were treated with FEr:YAG at 28 J/cm(2) and 5% density. Six biopsied specimens were obtained from each area. A total of 96 specimens (24 specimens from each area) were collected from four patients and examined randomly by two dermatopathologists. The ablative width and coagulative depth from each specimen were determined. In FCO2-treated specimens, the mean AW of the specimens that were pre-treated with TAC and control was 174.86 ± 24.57 and 188.52 ± 41.32 μm. The mean CD of the specimens that were pre-treated with TAC and control was 594.96 ± 111.72 and 520.03 ± 147.40 μm. There were no significant differences in AW and CD between both groups (p = 0.53 and p = 0.15). In FEr:YAG-treated specimens, the mean AW of the specimens that were pre-treated with TAC and control was 381.11 ± 48.02 and 423.65 ± 60.16 μm. The mean CD of the specimens that were pre-treated with TAC and control was 86.03 ± 29.44 and 71.59 ± 18.99 μm. There were no significant differences in AW and CD between both groups (p = 0.16 and p = 0.24). The pre

  11. Prediction and mitigation of air preheater fouling due to ammonium bisulfate

    Energy Technology Data Exchange (ETDEWEB)

    Afonso, R.; Tavoulareas, S.; Stallings, J. [Energy and Environmental Strategies, MA (United States)

    2001-07-01

    This paper provides a brief review of the fundamentals of ammonium bisulfate (ABS) formation, deposition and fouling in the air preheater. It presents a software-based predictive model for assessing the potential for air preheater fouling as a result of proposed SNCR or SCR retrofits and considering site-specific conditions and introduces a software-based cost-benefit model for assessing the economic trade-offs of various ABS fouling mitigation options. 7 refs., 13 figs.

  12. Stellar and HI Mass Functions Predicted by a Simple Preheating Galaxy Formation Model

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    According to the new preheating mechanism of galaxy formation suggested by Mo et al., we construct a simple model of formation of disk galaxies within the current paradigm of galaxy formation. It incorporates preheating, gas cooling, bulge formation and star formation. The predicted stellar and HI mass functions of galaxies are discussed and compared with the observations. It is found that our model can roughly match both the observed galaxy luminosity function and the observed HI-mass function.

  13. Effects of Preheat on Weldments of NICOP Steel.

    Science.gov (United States)

    1983-09-01

    in the base and base/HAZ regions and increasing amounts of bainite and auto tempered martensite islands near the fusion line. From the point of view...The microstructures were polygonal and acicular ferrite in the base and base/HAZ regions and increasing amounts of bainite and auto tempered...columbium is allowed to dissolve in austenite the columbium will tend to retard ferrite formation and promote acicular or bainite structure formation

  14. Cosmological Simulations of the Preheating Scenario for Galaxy Cluster Formation: Comparison to Analytic Models and Observations

    CERN Document Server

    Younger, Joshua D

    2007-01-01

    We perform a set of non--radiative cosmological simulations of a preheated intracluster medium in which the entropy of the gas was uniformly boosted at high redshift. The results of these simulations are used first to test the current analytic techniques of preheating via entropy input in the smooth accretion limit. When the unmodified profile is taken directly from simulations, we find that this model is in excellent agreement with the results of our simulations. This suggests that preheated efficiently smoothes the accreted gas, and therefore a shift in the unmodified profile is a good approximation even with a realistic accretion history. When we examine the simulation results in detail, we do not find strong evidence for entropy amplification, at least for the high-redshift preheating model adopted here. In the second section of the paper, we compare the results of the preheating simulations to recent observations. We show -- in agreement with previous work -- that for a reasonable amount of preheating, a...

  15. Atrial fibrillation ablation using a closed irrigation radiofrequency ablation catheter.

    Science.gov (United States)

    Golden, Keith; Mounsey, John Paul; Chung, Eugene; Roomiani, Pahresah; Morse, Michael Andew; Patel, Ankit; Gehi, Anil

    2012-05-01

    Catheter ablation is an effective therapy for symptomatic, medically refractory atrial fibrillation (AF). Open-irrigated radiofrequency (RF) ablation catheters produce transmural lesions at the cost of increased fluid delivery. In vivo models suggest closed-irrigated RF catheters create equivalent lesions, but clinical outcomes are limited. A cohort of 195 sequential patients with symptomatic AF underwent stepwise AF ablation (AFA) using a closed-irrigation ablation catheter. Recurrence of AF was monitored and outcomes were evaluated using Kaplan-Meier survival analysis and Cox proportional hazards models. Mean age was 59.0 years, 74.9% were male, 56.4% of patients were paroxysmal and mean duration of AF was 5.4 years. Patients had multiple comorbidities including hypertension (76.4%), tobacco abuse (42.1%), diabetes (17.4%), and obesity (mean body mass index 30.8). The median follow-up was 55.8 weeks. Overall event-free survival was 73.6% with one ablation and 77.4% after reablation (reablation rate was 8.7%). Median time to recurrence was 26.9 weeks. AF was more likely to recur in patients being treated with antiarrhythmic therapy at the time of last follow-up (recurrence rate 30.3% with antiarrhythmic drugs, 13.2% without antiarrhythmic drugs; hazard ratio [HR] 2.2, 95% confidence interval [CI] 1.1-4.4, P = 0.024) and in those with a history of AF greater than 2 years duration (HR 2.7, 95% CI 1.1-6.9, P = 0.038). Our study represents the largest cohort of patients receiving AFA with closed-irrigation ablation catheters. We demonstrate comparable outcomes to those previously reported in studies of open-irrigation ablation catheters. Given the theoretical benefits of a closed-irrigation system, a large head-to-head comparison using this catheter is warranted. ©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.

  16. Effects of oxidizing medium on the composition, morphology and optical properties of copper oxide nanoparticles produced by pulsed laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Gondal, M.A., E-mail: magondal@kfupm.edu.sa [Laser Research Laboratory, Physics Department and Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Qahtan, Talal F.; Dastageer, M.A. [Laser Research Laboratory, Physics Department and Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Saleh, Tawfik A. [Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Maganda, Yasin W. [Laser Research Laboratory, Physics Department and Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Anjum, D.H. [Nanofabrication, Imaging and Characterization Core Lab, King Abdullah University of Science and Technology (KAUST), Thuwal 23599-6900 (Saudi Arabia)

    2013-12-01

    Pulsed laser ablation in liquid (PLAL) with 532 nm wavelength laser with 5 ns pulse duration is used to produce the nanostructure copper oxide and the effects of oxidizing media (deionized water and hydrogen peroxide) on the composition, morphology and optical properties of the product materials produced by PLAL were studied. XRD and TEM studies indicate that in the absence of hydrogen peroxide, the product material is in two phases (Cu/Cu{sub 2}O) with the spherical nanoparticle structure, whereas in the presence of hydrogen peroxide in the liquid medium, the product material revealed other two phases (Cu/CuO) with nanorod-like structure. The optical studies revealed a considerable red shift (3.34–2.5 eV) in the band gap energy in the case of hydrogen peroxide in the liquid medium in PLAL synthesis compared to the one in the absence of it. Also the product material in the presence of hydrogen peroxide in the liquid medium showed a reduced photoluminescence intensity indicating the reduced electron–hole recombination rate. The red shift in the band gap energy and the reduced electron–hole recombination rate make the product material an ideal photocatalyst to harvest solar radiation for various applications. The most relevant signals on the FTIR spectrum for the samples are the absorption bands in the region between 450 and 700 cm{sup −1} which are the characteristics bands of copper-oxygen bonds. The reported laser ablation approach for the synthesis of Cu{sub 2}O and CuO nanoparticles has the advantages of being clean method with controlled particle properties.

  17. Effects of oxidizing medium on the composition, morphology and optical properties of copper oxide nanoparticles produced by pulsed laser ablation

    KAUST Repository

    Gondal, M. A.

    2013-12-01

    Pulsed laser ablation in liquid (PLAL) with 532 nm wavelength laser with 5 ns pulse duration is used to produce the nanostructure copper oxide and the effects of oxidizing media (deionized water and hydrogen peroxide) on the composition, morphology and optical properties of the product materials produced by PLAL were studied. XRD and TEM studies indicate that in the absence of hydrogen peroxide, the product material is in two phases (Cu/Cu2O) with the spherical nanoparticle structure, whereas in the presence of hydrogen peroxide in the liquid medium, the product material revealed other two phases (Cu/CuO) with nanorod-like structure. The optical studies revealed a considerable red shift (3.34-2.5 eV) in the band gap energy in the case of hydrogen peroxide in the liquid medium in PLAL synthesis compared to the one in the absence of it. Also the product material in the presence of hydrogen peroxide in the liquid medium showed a reduced photoluminescence intensity indicating the reduced electron-hole recombination rate. The red shift in the band gap energy and the reduced electron-hole recombination rate make the product material an ideal photocatalyst to harvest solar radiation for various applications. The most relevant signals on the FTIR spectrum for the samples are the absorption bands in the region between 450 and 700 cm-1 which are the characteristics bands of copperoxygen bonds. The reported laser ablation approach for the synthesis of Cu2O and CuO nanoparticles has the advantages of being clean method with controlled particle properties. © 2013 Elsevier B.V. All rights reserved.

  18. Endovascular radiofrequency ablation. Effect on the vein diameter using the ClosureFast(®) catheter.

    Science.gov (United States)

    Bauzá Moreno, Hernán; Dotta, Mariana; Katsini, Roxana; Marquez Fosser, Carolina; Rochet, Sofía; Pared, Carlos; Martinez, Hugo

    2016-01-01

    Endovascular radiofrequency with first generation catheters was not successful due to its technical difficulty and restrictions in veins with diameters larger than 12mm. However, using the new catheter there is not enough scientific evidence to affirm that the diameter represents a technical limitation. The aim of this study was to evaluate and compare pre and post-operative venous trunks diameter, aiming at the reduction of size after 6 months with last generation catheters. Retrospective observational and descriptive study on a cohort of patients with insufficiency of the great saphenous vein, small saphenous vein and anterior accessory vein operated on with last generation radiofrequency catheters. The diameters were evaluated in the pre and post-operative period with ultrasound. Between 2007 and 2014 a total of 365 ablations were performed in veins with an average diameter of 9±3.1mm showing a reduction of it after 6 months with a mean value of 5.2±0.8mm (P<.0001). Total occlusion was also observed in 100% of cases and complications such as deep vein thrombosis in 0.5% and heat-induced thrombosis in 1.1%. A significant reduction in venous diameter after endovascular treatment with the new ClosureFast(®) catheters was checked, even in veins with diameters greater than 12mm. Copyright © 2016 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  19. Effects of the confining solvent on the size distribution of silver NPs by laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Oseguera-Galindo, D. O., E-mail: david.omar0927@hotmail.com; Martinez-Benitez, A.; Chavez-Chavez, A.; Gomez-Rosas, G.; Perez-Centeno, A.; Santana-Aranda, M. A., E-mail: miguelangelsantana@gmail.com [CUCEI, Universidad de Guadalajara, Departamento de Fisica (Mexico)

    2012-09-15

    Laser ablation of a silver target confined in acetone, ethanol, methanol, propanol, and distilled water allowed us to obtain silver nanoparticles with different size distributions. We employed a pulsed Nd:YAG laser ({lambda} = 532 nm, 0.5 J/pulse) with a high fluence of 64 J/cm{sup 2} with a scanning density of 2,500 pulses/cm{sup 2}, having overlapping of consecutive pulses. The analysis of transmission electron micrographs showed that the smaller particle sizes were obtained confining the target in propanol, while the larger ones were obtained employing ethanol. Nanoparticle size distributions were fitted with two Gaussian peaks in all five cases, being the smaller sizes the most frequent. Predominant peaks were centered at 4.8 and 13.9 nm in propanol and ethanol, respectively, having a broader distribution for the nanoparticles obtained in ethanol. Furthermore, comparison of electron micrographs taken the day of synthesis and 4 and 9 months later in the case of water and propanol, respectively, shows that nanoparticle suspension is more stable in propanol.

  20. Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer

    Directory of Open Access Journals (Sweden)

    Tan Aaron

    2012-07-01

    Full Text Available Abstract Background The application of nanotechnology in biology and medicine represents a significant paradigm shift in the approach to the treatment of cancer. Evidence suggests that when exposed to near-infrared radiation (NIR, carbon nanotubes (CNTs dissipate a substantial amount of heat energy. We have developed a novel nanocomposite polymer, polyhedral oligomeric silsesquioxane poly (carbonate-urea urethane (POSS-PCU. POSS-PCU displays excellent biocompatibility and has been used in making artificial organs as well as protective coatings for medical devices. Results Functionalizing (or “coating” CNTs with POSS-PCU confers biocompatibility and increase the amount of heat energy generated, by enhancing dispersion. Here we demonstrate that POSS-PCU-functionalized multi-walled CNTs (MWNTs act synergistically together when exposed to NIR to thermally ablate cancer cells. Conclusion Given that POSS-PCU has already been used in human in first-in-man studies as trachea, lacrimal duct, bypass graft and other organs, our long-term goal is to take POSS-PCU coated CNTs to clinical studies to address the treatment of cancer by optimizing its therapeutic index and increasing its specificity via antibody conjugation.

  1. Early lens ablation causes dramatic long-term effects on the shape of bones in the craniofacial skeleton of Astyanax mexicanus.

    Science.gov (United States)

    Dufton, Megan; Hall, Brian K; Franz-Odendaal, Tamara A

    2012-01-01

    The Mexican tetra, Astyanax mexicanus, exists as two morphs of a single species, a sighted surface morph and a blind cavefish. In addition to eye regression, cavefish have an increased number of taste buds, maxillary teeth and have an altered craniofacial skeleton compared to the sighted morph. We investigated the effect the lens has on the development of the surrounding skeleton, by ablating the lens at different time points during ontogeny. This unique long-term study sheds light on how early embryonic manipulations on the eye can affect the shape of the adult skull more than a year later, and the developmental window during which time these effects occur. The effects of lens ablation were analyzed by whole-mount bone staining, immunohistochemisty and landmark based morphometric analyzes. Our results indicate that lens ablation has the greatest impact on the skeleton when it is ablated at one day post fertilisation (dpf) compared to at four dpf. Morphometric analyzes indicate that there is a statistically significant difference in the shape of the supraorbital bone and suborbital bones four through six. These bones expand into the eye orbit exhibiting plasticity in their shape. Interestingly, the number of caudal teeth on the lower jaw is also affected by lens ablation. In contrast, the shape of the calvariae, the length of the mandible, and the number of mandibular taste buds are unaltered by lens removal. We demonstrate the plasticity of some craniofacial elements and the stability of others in the skull. Furthermore, this study highlights interactions present between sensory systems during early development and sheds light on the cavefish phenotype.

  2. The effect of integrated cardiac rehabilitation versus treatment as usual for atrial fibrillation patients treated with ablation: the randomised CopenHeartRFA trial protocol

    Science.gov (United States)

    Risom, Signe Stelling; Zwisler, Ann-Dorth Olsen; Rasmussen, Trine Bernholdt; Sibilitz, Kirstine Lærum; Svendsen, Jesper Hastrup; Gluud, Christian; Hansen, Jane Lindschou; Winkel, Per; Thygesen, Lau Caspar; Perhonen, Merja; Hansen, Jim; Dunbar, Sandra B; Berg, Selina Kikkenborg

    2013-01-01

    Introduction Atrial fibrillation affects almost 2% of the population in the Western world. To preserve sinus rhythm, ablation is undertaken in symptomatic patients. Observational studies show that patients with atrial fibrillation often report a low quality of life and are less prone to be physically active due to fear of triggering fibrillation. Small trials indicate that exercise training has a positive effect on exercise capacity and mental health, and both patients with recurrent atrial fibrillation and in sinus rhythm may benefit from rehabilitation in managing life after ablation. No randomised trials have been published on cardiac rehabilitation for atrial fibrillation patients treated with ablation that includes exercise and psychoeducational components. Aim To test the effects of an integrated cardiac rehabilitation programme versus treatment as usual for patients with atrial fibrillation treated with ablation. Methods and analysis design The trial is a multicentre parallel arm design with 1:1 randomisation to the intervention and control group with blinded outcome assessment. 210 patients treated for atrial fibrillation with radiofrequency ablation will be included. The intervention consists of a rehabilitation programme including four psychoeducative consultations with a specially trained nurse and 12 weeks of individualised exercise training, plus the standard medical follow-up. Patients in the control group will receive the standard medical follow-up. The primary outcome measure is exercise capacity measured by the VO2 peak. The secondary outcome measure is self-rated mental health measured by the Short Form 36 questionnaire. Postintervention, qualitative interviews will be conducted in 10% of the intervention group. Ethics and dissemination The protocol is approved by the regional research ethics committee (number H-1-2011-135), the Danish Data Protection Agency (reg. nr. 2007-58-0015) and follows the latest version of the Declaration of Helsinki

  3. Corrosion on air preheaters and economisers; Korrosion hos luftfoervaermare och ekonomisrar

    Energy Technology Data Exchange (ETDEWEB)

    Nordling, Magnus

    2012-05-15

    Combustion plants in Sweden are exposed to considerable stress regarding low temperature corrosion, and failures due to low temperature corrosion occur regularly. Particularly common is corrosion problems connected to air preheaters and economisers. The number of combustion plants having air preheaters and economisers is however large, and the result of a collection of experiences regarding corrosion on air preheaters and economisers therefore has the potential to give a broad knowledge base. The summary of collection of experiences that has been done here, complemented with a literature survey, is expected to give plant owners and plant constructors a valuable tool to prevent corrosion on the flue gas side of air preheaters and economisers. The choice of plants for the inquiry was made using a list from the Swedish Naturvaardsverket (Environmental Protection Agency) indicating the emissions of NO{sub x}gases from Swedish combustion plants. From that list mainly the plants with the largest emissions were chosen, resulting in a number of 30 plants. Depending on that most of the plants have several boilers, and that the connected tubes often have several economisers and air preheaters, the number of economisers and air preheaters in this experience collection is at least 85. The study was however not limited to economisers and air preheaters, but also experiences connected to corrosion of other units were collected when mentioned, and the most interesting information here is also included in the report. Also a number of the plants were visited to improve the basis of the report, e.g. by photographing the most interesting parts. As the insight of the extension of the problem increased, renewed interview rounds were made, and the last one was made in August 2011.

  4. Thermal Ablation for Benign Thyroid Nodules: Radiofrequency and Laser

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Jung Hwan; Lee, Jeong Hyun [University of Ulsan College of Medicine, Asan Medical Center, Seoul (Korea, Republic of); Valcavi, Roberto [Endocrinology Division and Thyroid Disease Center, Arcispedale Santa Maria Nuova, Reggio Emilia (Italy); Pacella, Claudio M. [Diagnostic Imaging and Interventional Radiology Department, Ospedale Regina Apostolorum, Albano Laziale-Rome (IT); Rhim, Hyun Chul [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Na, Dong Kyu [Human Medical Imaging and Intervention Center, Seoul (Korea, Republic of)

    2011-10-15

    Although ethanol ablation has been successfully used to treat cystic thyroid nodules, this procedure is less effective when the thyroid nodules are solid. Radiofrequency (RF) ablation, a newer procedure used to treat malignant liver tumors, has been valuable in the treatment of benign thyroid nodules regardless of the extent of the solid component. This article reviews the basic physics, techniques, applications, results, and complications of thyroid RF ablation, in comparison to laser ablation.

  5. Monitoring of tumor radio frequency ablation using derivative spectroscopy

    NARCIS (Netherlands)

    Spliethoff, J.W.; Tanis, E.; Evers, Daniel James; Hendriks, B.H.; Prevoo, W.; Ruers, T.J.M.

    2014-01-01

    Despite the widespread use of radio frequency (RF) ablation, an effective way to assess thermal tissue damage during and after the procedure is still lacking. We present a method for monitoring RF ablation efficacy based on thermally induced methemoglobin as a marker for full tissue ablation. Diffus

  6. Nanodrug-enhanced radiofrequency tumor ablation: effect of micellar or liposomal carrier on drug delivery and treatment efficacy.

    Directory of Open Access Journals (Sweden)

    Marwan Moussa

    Full Text Available PURPOSE: To determine the effect of different drug-loaded nanocarriers (micelles and liposomes on delivery and treatment efficacy for radiofrequency ablation (RFA combined with nanodrugs. MATERIALS/METHODS: Fischer 344 rats were used (n = 196. First, single subcutaneous R3230 tumors or normal liver underwent RFA followed by immediate administration of i.v. fluorescent beads (20, 100, and 500 nm, with fluorescent intensity measured at 4-24 hr. Next, to study carrier type on drug efficiency, RFA was combined with micellar (20 nm or liposomal (100 nm preparations of doxorubicin (Dox; targeting HIF-1α or quercetin (Qu; targeting HSP70. Animals received RFA alone, RFA with Lipo-Dox or Mic-Dox (1 mg i.v., 15 min post-RFA, and RFA with Lipo-Qu or Mic-Qu given 24 hr pre- or 15 min post-RFA (0.3 mg i.v.. Tumor coagulation and HIF-1α or HSP70 expression were assessed 24 hr post-RFA. Third, the effect of RFA combined with i.v. Lipo-Dox, Mic-Dox, Lipo-Qu, or Mic-Qu (15 min post-RFA compared to RFA alone on tumor growth and animal endpoint survival was evaluated. Finally, drug uptake was compared between RFA/Lipo-Dox and RFA/Mic-Dox at 4-72 hr. RESULTS: Smaller 20 nm beads had greater deposition and deeper tissue penetration in both tumor (100 nm/500 nm and liver (100 nm (p<0.05. Mic-Dox and Mic-Qu suppressed periablational HIF-1α or HSP70 rim thickness more than liposomal preparations (p<0.05. RFA/Mic-Dox had greater early (4 hr intratumoral doxorubicin, but RFA/Lipo-Dox had progressively higher intratumoral doxorubicin at 24-72 hr post-RFA (p<0.04. No difference in tumor growth and survival was seen between RFA/Lipo-Qu and RFA/Mic-Qu. Yet, RFA/Lipo-Dox led to greater animal endpoint survival compared to RFA/Mic-Dox (p<0.03. CONCLUSION: With RF ablation, smaller particle micelles have superior penetration and more effective local molecular modulation. However, larger long-circulating liposomal carriers can result in greater intratumoral drug

  7. Pulsed laser ablation of wire-shaped target in a thin water jet: effects of plasma features and bubble dynamics on the PLAL process

    Science.gov (United States)

    Dell'Aglio, Marcella; De Giacomo, Alessandro; Kohsakowski, Sebastian; Barcikowski, Stephan; Wagener, Philipp; Santagata, Antonio

    2017-05-01

    In this paper, emission spectroscopy and fast imaging surveys during pulsed laser ablation in liquid (PLAL) for nanoparticles (NPs) production have been used, in order to provide further details about the process involved and the potentialities offered by a wire-shaped sample ablated in a flowing water jet. This kind of set-up has been explored because the laser ablation efficiency in water increases when a thin water layer and a wire-shaped target are used. In order to understand the physical processes causing the increasing ablation efficiency, both the laser-induced plasma and bubble dynamics generated in a flowing liquid jet have been analysed. The plasma parameters and the bubble behaviour in such a system have been compared with those observed in conventional PLAL experiments, where either a bulk or a wire-shaped target is immersed in bulk water. From the data presented here it is evidenced that the plasma and shockwave induced during the breakdown process can play a direct role in the ablation efficiency variation observed. With regard to the cavitation bubbles evolving near a free surface (the interface between water and air) it should be noted that these have to be treated with caution as a consequence of the strong influence played in these circumstances by the boundary of the water jet during its expansion dynamics. The effects due to the size of the liquid layer, the presence of the water/air interface, the liquid characteristics, the target shape, the plasma evolution and the bubble dynamics together with their outcomes on the NPs’ production, are presented and discussed.

  8. Influence of combustion-preheating vitiation on operability of a hypersonic inlet

    Science.gov (United States)

    Liu, K.; Zhu, Y.; Gao, W.; Yang, J.; Jin, Y.; Wu, Y.

    2016-11-01

    Vitiation of the test flow with combustion products is inherent in combustion wind tunnels, and its effect on experimental results needs to be clarified. In this study, the influence of air vitiation on the startability and performance of a hypersonic inlet is investigated through two-dimensional (2D) numerical simulation. The study examines the vitiation effects introduced by carbon dioxide and water vapor, on the basis of maintaining the static pressure, static temperature and Mach number of the incoming flow. The starting Mach number limits of the inlet are estimated, and it is found that both of these vitiation components lower the starting limit of the inlet. This suggests that the experimental results acquired by tests in combustion wind tunnels overestimate the startability of an inlet and, therefore, combustion-preheated facilities may not be completely trusted in this respect. Deviations in the inlet performance caused by the vitiation are also detected. These are nevertheless minor as long as the flow is at the same started or unstarted condition. A further analysis reveals that it is mainly the increase in the heat capacity, and the resulting weaker shock/compression waves and shock-wave/boundary-layer interactions that account for the aforementioned effects.

  9. 预热工艺对钢化玻璃性能的影响%Influence of Preheating Process on the Properties of Tempered Glass

    Institute of Scientific and Technical Information of China (English)

    赵旭东

    2015-01-01

    6mm clear glass produced by TAMGLASS Company was processed to be tempered glass by the double chamber hori-zontal tempering furnace production line. The conditions of different preheating ( such as preheat temperature, the up/down convec-tion) on the properties of tempered glass were studied. By adjusting the different parameters of preheating and measurement of tem-pered glass bending, tempered parameters, the paper analyzes the effects of preheating parameters on the performance of the tem-pered glass, and the results are discussed. Results show that the parameters such as preheat temperature, preheat convection en-hance the substrate temperature of glass in the heating period of heat to be faster, better heat evenly;it enhances the smoothness of tempered glass and the apparent quality of the final product has obviously improved. Through the optimal parameter combination, glass products with a group of excellent properties are toughened.%利用TAMGLASS公司生产的双室强对流水平钢化炉生产线对南玻公司生产的6 mm白玻璃进行了钢化处理,研究了不同预热条件(预热温度、上下对流设置等)对钢化玻璃性能的影响。通过调整不同的预热参数以及测量钢化后的玻璃弯曲度、钢化应力、表观质量等参数,分析了预热参数对钢化玻璃性能的影响,并对实验结果进行了讨论。结果表明:设置合适的预热温度、预热对流等参数可提高玻璃的基体温度,使得玻璃在加热段的加热更快、受热更加均匀,提高了钢化玻璃的平整度,对最终产品的表观质量有明显改善。

  10. The synergistic effects of radiofrequency ablation (RFA) with glycated chitosan for inhibiting the metastasis of breast cancer

    Science.gov (United States)

    Chiu, Hsin-Yu; Leu, Jyh-Der; Chen, Wei R.; Lee, Yi-Jang

    2016-03-01

    . Plasma extraction from this group displayed an inhibitory effect on cultured 4T1 cells, suggesting some immunoreactions were triggered and therefore secreted some cytokines. Protein array data indicated that PF-4 may play a key role in GC-RFA caused tumor suppression but the further effects should be investigated. On the other hand, the survival rate of small tumor-bearing mice under RFA-GC treatment was higher than those of GC or RFA treatment only. In conclusion, this study confirmed that radiofrequency ablation combined with GC could trigger an autoimmune response to inhibit tumor metastasis and tumorigenesis. For metastatic cancers, this combination treatment may become the foundation for a feasible cancer treatment modality.

  11. Ultrasound-guided alcohol neurolysis and radiofrequency ablation of painful stump neuroma: effective treatments for post-amputation pain

    Science.gov (United States)

    Zhang, Xin; Xu, Yongming; Zhou, Jin; Pu, Shaofeng; Lv, Yingying; Chen, Yueping; Du, Dongping

    2017-01-01

    Background Post-amputation pain (PAP) is highly prevalent after limb amputation, and stump neuromas play a key role in the generation of the pain. Presently, PAP refractory to medical management is frequently treated with minimally invasive procedures guided by ultrasound, such as alcohol neurolysis and radiofrequency ablation (RFA). Objective To record the immediate and long-term efficacy of alcohol neurolysis and RFA. We first used alcohol neurolysis and then, when necessary, we performed RFA on PAP patients. Study design Prospective case series. Setting Pain management center. Methods Thirteen subjects were treated with ultrasound-guided procedures. Results All patients were treated with neurolysis using alcohol solutions guided by ultrasound. Seven (54%) of 13 subjects achieved pain relief after 1–3 alcohol injection treatments. The remaining 6 subjects obtained pain relief after receiving 2 administrations of ultrasound-guided RFA. After a 6-month follow-up evaluation period, pain quantities were also assessed. Both stump pain (including intermittent sharp pain and continuous burning pain) and phantom pain were relieved. The frequency of intermittent sharp pain was decreased, and no complications were noted during the observation. Conclusion The use of ultrasound guidance for alcohol injection and RFA of painful stump neuromas is a simple, radiation-free, safe, and effective procedure that provides sustained pain relief in PAP patients. In this case series, RFA was found to be an effective alternative to alcohol injection. PMID:28223839

  12. Safety and Effectiveness of Endovenous Laser Ablation Combined With Ligation for Severe Saphenous Varicose Veins in Japanese Patients.

    Science.gov (United States)

    Izumi, Masafumi; Ikeda, Yuichi; Yamashita, Hiroharu; Asaoka, Yoshinari; Fujishiro, Mitsuhiro; Shin, Masahiro; Abo, Yoshihisa

    2016-01-01

    Endovenous laser ablation (EVLA), which is a relatively new therapeutic option for saphenous varicose veins of the legs, is less invasive than conventional stripping surgery with ligation. In this study, we evaluated the safety and effectiveness of EVLA combined with ligation for severe saphenous varicose veins that were graded as ≥ C4 by the CEAP classification. We treated 119 Japanese patients (141 limbs) between July 2005 and December 2007 utilizing a 1320-nm Nd:YAG laser. The obliteration rate of the treated veins was found to be 100% over the entire follow-up period (2.5 years). Consistent with this finding, all of the patients exhibited improved skin lesions (ie, skin pigmentation and ulceration). No major complications, including deep vein thrombosis (DVT) and nerve injury, were observed. A questionnaire survey with a reasonable response rate (66.4%) demonstrated that subjective symptoms and minor complications that were initially observed after EVLA, such as mild pain, numbness, indurations, and localized hot flashes, were remarkably improved by the end of the follow-up period. Furthermore, high levels of patient satisfaction were noted. Thus, EVLA combined with ligation constituted a safe and effective strategy for treating severe saphenous varicose veins in Japanese patients.

  13. Flexural Strength of Preheated Resin Composites and Bonding Properties to Glass-Ceramic and Dentin

    Directory of Open Access Journals (Sweden)

    Matthias Richard Kramer

    2016-01-01

    Full Text Available To test the impact of preheating (25, 37, 54, or 68 °C of TetricEvoCeram (TEC, FiltekSupremeXT (FSXT, and Venus (V on flexural strength (FS, shear bond strength (SBS and interfacial tension (IFT. FS was tested with TEC and FSXT. For SBS, glass-ceramic and human dentin substrate were fabricated and luted with the preheated resin composite (RC. SBSs of 1500 thermal cycled specimens were measured. For IFT, glass slides covered with the non-polymerized RC were prepared and contact angles were measured. Data were analyzed using 2/1-way ANOVA with Scheffé-test, and t-test (p < 0.05. Preheated TEC (37–68 °C showed higher FS compared to the control-group (25 °C (p < 0.001. FSXT presented higher FS than TEC (p < 0.001. For SBS to dentin higher values for FSXT than TEC were found. The preheating temperature showed no impact on SBS to dentin. SBS to glass-ceramic revealed a positive influence of temperature for TEC 25–68 °C (p = 0.015. TEC showed higher values than V and FSXT (p < 0.001. IFT values increased with the preheating temperature. A significant difference could be observed in every RC group between 25 and 68 °C (p < 0.001.

  14. A drug-perfluorocarbon nanoemulsion with an ultrathin silica coating for the synergistic effect of chemotherapy and ablation by high-intensity focused ultrasound.

    Science.gov (United States)

    Ma, Ming; Xu, Huixiong; Chen, Hangrong; Jia, Xiaoqing; Zhang, Kun; Wang, Qi; Zheng, Shuguang; Wu, Rong; Yao, Minghua; Cai, Xiaojun; Li, Faqi; Shi, Jianlin

    2014-11-19

    The synergistic effect of chemotherapy and ablation using high-intensity focused ultrasound (HIFU) is realized with a newly developed drug-delivery system. The system comprises an ultrathin silica shell surrounding a poly(lactic-co-glycolic acid) nanoemulsion core containing the drug (CPT) and a perfluorocarbon (PFOB). This nanosystem presents many advantages in drug delivery, such as excellent structural stability, high drug-loading capacity, and rapid HIFU-mediated drug release.

  15. Microwave ablation of hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Although surgical resection is still the optimal treatmentoption for early-stage hepatocellular carcinoma(HCC) in patients with well compensated cirrhosis,thermal ablation techniques provide a valid nonsurgicaltreatment alternative, thanks to their minimalinvasiveness, excellent tolerability and safety profile,proven efficacy in local disease control, virtuallyunlimited repeatability and cost-effectiveness. Differentenergy sources are currently employed in clinics asphysical agents for percutaneous or intra-surgicalthermal ablation of HCC nodules. Among them, radiofrequency(RF) currents are the most used, whilemicrowave ablations (MWA) are becoming increasinglypopular. Starting from the 90s', RF ablation (RFA) rapidlybecame the standard of care in ablation, especially inthe treatment of small HCC nodules; however, RFAexhibits substantial performance limitations in thetreatment of large lesions and/or tumors located nearmajor heat sinks. MWA, first introduced in the FarEastern clinical practice in the 80s', showing promisingresults but also severe limitations in the controllabilityof the emitted field and in the high amount of poweremployed for the ablation of large tumors, resultingin a poor coagulative performance and a relativelyhigh complication rate, nowadays shows better resultsboth in terms of treatment controllability and of overallcoagulative performance, thanks to the improvementof technology. In this review we provide an extensiveand detailed overview of the key physical and technicalaspects of MWA and of the currently available systems,and we want to discuss the most relevant published dataon MWA treatments of HCC nodules in regard to clinicalresults and to the type and rate of complications, both inabsolute terms and in comparison with RFA.

  16. Effect of in situ annealing on structure and optical properties of ZnTe nanoparticles produced by pulsed laser ablation

    Science.gov (United States)

    Orii, Takaaki; Hirasawa, Makoto; Seto, Takafumi

    2007-04-01

    An improvement in morphology, crystallinity, and optical property of ZnTe nanoparticles produced by pulsed laser ablation (PLA) was achieved by in situ annealing. ZnTe nanoparticles produced in argon gas ambience by PLA were annealed in the gas flow at a temperatures Ta ranging from 300 °C to 800 °C and size-selected by a differential mobility analyzer. The bimodal size distribution of the ZnTe nanoparticles changed to unimodal at Ta = 600 °C. In this condition, the shape of the monodispersed ZnTe nanoparticles, classified into around 20 nm, became uniformly spherical and their crystallinity estimated by x-ray diffraction was extremely improved. These improvements by the in situ annealing were examined for ZnTe nanoparticles produced from off-stoichiometric target. Although the optical property of ZnTe nanoparticles produced from a zinc rich target was improved, those produced from a tellurium rich target could not be improved. It was found that the effect of in situ annealing on optical properties of ZnTe nanoparticles was dependent upon its content.

  17. Effect of in situ annealing on structure and optical properties of ZnTe nanoparticles produced by pulsed laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Orii, Takaaki [Research Consortium for Synthetic Nano-Function Materials Project (SYNAF), National Institute of Advanced Industrial Science and Technology (AIST), Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki, 305-8568 (Japan); Hirasawa, Makoto [Research Consortium for Synthetic Nano-Function Materials Project (SYNAF), National Institute of Advanced Industrial Science and Technology (AIST), Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki, 305-8568 (Japan); Seto, Takafumi [Research Consortium for Synthetic Nano-Function Materials Project (SYNAF), National Institute of Advanced Industrial Science and Technology (AIST), Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki, 305-8568 (Japan)

    2007-04-15

    An improvement in morphology, crystallinity, and optical property of ZnTe nanoparticles produced by pulsed laser ablation (PLA) was achieved by in situ annealing. ZnTe nanoparticles produced in argon gas ambience by PLA were annealed in the gas flow at a temperatures T{sub a} ranging from 300 deg. C to 800 deg. C and size-selected by a differential mobility analyzer. The bimodal size distribution of the ZnTe nanoparticles changed to unimodal at T{sub a} = 600 deg. C. In this condition, the shape of the monodispersed ZnTe nanoparticles, classified into around 20 nm, became uniformly spherical and their crystallinity estimated by x-ray diffraction was extremely improved. These improvements by the in situ annealing were examined for ZnTe nanoparticles produced from off-stoichiometric target. Although the optical property of ZnTe nanoparticles produced from a zinc rich target was improved, those produced from a tellurium rich target could not be improved. It was found that the effect of in situ annealing on optical properties of ZnTe nanoparticles was dependent upon its content.

  18. Effect of ambient gas pressure on pulsed laser ablation plume dynamics and ZnTe film growth

    Energy Technology Data Exchange (ETDEWEB)

    Rouleau, C.M.; Lowndes, D.H.; Geohegan, D.B.; Allard, L.F. [Oak Ridge National Lab., TN (United States); Strauss, M.A.; Cao, S.; Pedraza, A.J. [Univ. of Tennessee, Knoxville, TN (United States). Dept. of Materials Science and Engineering; Puretzky, A.A. [Inst. of Spectroscopy, Troitsk (Russian Federation)

    1995-12-01

    Epitaxial thin films of nitrogen-doped p-ZnTe were grown on single-crystal, semi-insulating Ga-As substrates via pulsed laser ablation of a stoichiometric ZnTe target. Both low pressure nitrogen ambients and high vacuum were used. Results of in situ reflection high energy electron diffraction (RHEED) and time-resolved ion probe measurements have been compared with ex situ Hall effect and transmission electron microscopy (TEM) measurements. A strong correlation was observed between the nature of the film`s surface during growth (2-D vs. 3-D, assessed via RHEED) and the ambient gas pressures employed during deposition. The extended defect content (assessed via cross-sectional TEM) in the region >150 mn from the film/substrate interface was found to increase with the ambient gas pressure during deposition, which could not be explained by lattice mismatch alone. At sufficiently high pressures, misoriented, columnar grains developed which were not only consistent with the RHEED observations but also were correlated with a marked decrease in Hall mobility and a slight decrease in hole concentration. Ion probe measurements, which monitored the attenuation and slowing of the ion current arriving at the substrate surface, indicated that for increasing nitrogen pressure the fast (vacuum) velocity distribution splits into a distinct fast and two collisionally-slowed components or modes. Gas controlled variations in these components mirrored trends in electrical properties and microstructural measurements.

  19. Effect of aging on copper nanoparticles synthesized by pulsed laser ablation in water: structural and optical characterizations

    Indian Academy of Sciences (India)

    R K Swarnkar; S C Singh; R Gopal

    2011-12-01

    Effect of aging on copper nanoparticles synthesized by pulsed laser ablation of copper plate in water was studied. By characterization studies of the aged nanoparticles, it is found that copper nanoparticles converted into Cu@Cu2O nanostructure. The synthesized nanomaterial is characterized with UV-Visible absorption, transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) and Raman and photoluminescence (PL) spectroscopic techniques. TEM image shows that the aged nanoparticles get assembled into cactus like structure and are spherical in shape with average diameter 7 nm and dispersion 2 nm. XRD and FTIR spectrum confirm the formation of Cu@Cu2O in the aged sample. Raman spectrum also confirms the presence of Cu2O nanoparticles. PL spectrum of the aged nanoparticles shows a direct allowed transition with bandgap energy of 2.24 eV. The mechanism for synthesis of core-shell nanoparticles and formation of self-assembly of nanoparticles is also discussed.

  20. EFFECTS OF LEVOTHYROXINE ON BONE METABOLISM IN PATIENTS WITH DIFFERENTIATED THYROID CANCER AFTER OPERATION AND 131I ABLATION

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective To investigate the effects of substitutive and suppressive doses of levothyroxine on bone metabolism in patients with differentiated thyroid carcinoma after surgery and 131I ablation. Methods The patients, who had received levothyroxine(L-T4) for at least 3 years for treating their differentiated thyroid carcinoma after surgery and 131I therapy, were classified into substitutive group and suppressive group according to the levels of serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH). We compared the levels of FT3, FT4, TSH, serum parathyroid hormone (PTH), serum calcium (Ca), serum phosphate (P), serum alkaline phosphates (ALP) and Bone mineral density (BMD) to those of healthy volunteers well matched for sex, age, menopausal status, and body mass index (BMI). Results No significant differences were found in the bone density and biochemical parameters of bone metabolism of the subjects treated with substitutive or suppressive doses of L-T4 compared with the control subgroup. No significant differences were observed among the subgroups according to accumulative doses of 131I. No bone fracture was found in all the patients. Conclusion The substitutive and suppressive doses of L-T4 are safe and necessary for patients with differentiated thyroid carcinoma after surgery and 131I therapy. Such treatment for 3 years is not associated with increased risk of osteoporosis. Much longer term of follow up is still needed in patients receiving substitutive and suppressive doses of L-T4.

  1. Graphene oxide wrapped SERS tags: multifunctional platforms toward optical labeling, photothermal ablation of bacteria, and the monitoring of killing effect.

    Science.gov (United States)

    Lin, Donghai; Qin, Tianqi; Wang, Yunqing; Sun, Xiuyan; Chen, Lingxin

    2014-01-22

    As novel optical nanoprobes, surface-enhanced Raman scattering (SERS) tags have drawn growing interests in the application of biomedical imaging and phototherapies. Herein, we demonstrated a novel in situ synthesis strategy for GO wrapped gold nanocluster SERS tags by using a tris(2,2'-bipyridyl)ruthenium(II) chloride (Rubpy)/GO nanohybrid as a complex Raman reporter, inspired by the role of GO as an artificial receptor for various dyes. The introduction of GO in the synthesis procedure provided systematic solutions for controlling several key parameters of SERS tags, including reproducibility, sensitivity, and colloidal and signal stability. An additional interesting thermal-sensitive SERS property (SERS intensity decreased upon increasing the temperature) was also achieved due to the heat-induced release/redistribution of reporter molecules adsorbed on GO. Combining the synergic effect of these features, we further fabricated multifunctional, aldehyde group conjugated Au@Rubpy/GO SERS tags for optical labeling and photothermal ablation of bacteria. Sensitive Raman imaging of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria could be realized, and satisfactory photothermal killing efficacy for both bacteria was achieved. Our results also demonstrated the correlation among the SERS intensity decrease ratio, bacteria survival rate, and the terminal temperature of the tag-bacteria suspension, showing the possibility to use SERS assay to measure antibacterial response during the photothermal process using this tag.

  2. Effect of anxiety and depression on the recurrence of persistent atrial fibrillation after circumferential pulmonary vein ablation

    Institute of Scientific and Technical Information of China (English)

    YU Sheng-bo; HU Wei; ZHAO Qing-yan; QIN Mu; HUANG He; CUI Hong-ying; HUANG Cong-xin

    2012-01-01

    Background The effects of anxiety and depression on the recurrence of persistent atrial fibrillation (AF) after circumferential pulmonary vein ablation (CPVA) are not clear.Whether CPVA can alleviate the anxiety and depression symptoms of persistent AF patients is unknown.Methods One hundred and sixty-four patients with persistent AF,of which 43 treated with CPVA (CPVA group) and 103 treated with anti-arrhythmics drugs (medicine group),were enrolled.The Zung Self-Rating Anxiety Scale (SAS),and Zung Self-Rating Depression Scale (SDS) were assessed before and 12 months after treatment in all patients.Results The scores of SAS (40.33±7.90 vs.49.76±9.52,P <0.01) and SDS (42.33±8.73 vs.48.17±8.77,P <0.01)decreased 12 months after CPVA.Over 12 months follow-up,AF relapsed in 17 patients in CPVA group.Compared with the data in the recurrent group (17 patients),the scores of SAS and SDS were significantly lower in the non-recurrent group (26 patients) at baseline.The results of multivariate Logistic regression analysis showed normal scores of SAS and SDS were the independent risk factors of AF recurrence after CPVA.Conclusions Anxiety and depression increase the recurrence risk of persistent AF after CPVA.CPVA can ameliorate the anxiety and depression symptoms in patients with persistent AF.

  3. Effectiveness of Computed Tomography Guided Percutaneous Radiofrequency Ablation Therapy for Osteoid Osteoma: Initial Results and Review of the Literature

    Science.gov (United States)

    Karagöz, Erdal; Özel, Deniz; Özkan, Fuat; Özel, Betül Duran; Özer, Özgur; Coşkun, Zafer Ünsal

    2016-01-01

    Summary Background The aim of this retrospective study is to determine our experience of technique success rate, complications and clinical results in long term follow up for computed tomography (CT)-guided radiofrequency ablation [RA] therapy for osteoid osteoma (OO). Material/Methods We performed RA therapy to 18 patients with OO referred to interventional radiology from other clinics primarily from orthopedics; between January 2011 to May 2014. Daytime and nighttime pain intensity of 18 patients was noted according to visual analog scale (VAS). After procedure pain intensity was compared with before one. We also discussed other factors can affect it. Results All procedures were completed technically successful for all patients [100%]. We did not experience any major complication or mortality. However we had 3 minor complications. Pain came back in 1 patient after 5 months from procedure and it was considered as recurrence. Dramatic pain intensity fall was seen in patients after procedure, both daytime and nighttime. However we did not find and statistically significant change in comparison of pain intensity reduce and time needed to return back to routine life when using patients demographic data and lesion size. Conclusions CT guided RA therapy of OO is minimally invasive, effective and secure procedure. PMID:27429671

  4. Performance Evaluation of Diesel Engine with Preheated Bio Diesel with Additives

    Science.gov (United States)

    Ram Vajja, Sai; Murali, R. B. V.

    2016-09-01

    This paper mainly reviews about the usage of preheated bio diesel added with 0.5% Etchant as an alternative fuel and evaluates its performance for various blends with different loads. Bio diesel is added with Etchant for rapid combustion as for the bio diesel, the cetane number is high that results in shorter delay of ignition and the mixture is preheated to raise its temperature to improve the combustion process. Analysis of the parameters required to define the combustion characteristics such as IP, BP, ηbth, ηm, ISFC, BSFC, IMEP, MFC, Exhaust Gas Temperature, Heat Release and heat balance is necessary as these values are significant to assess the performance of engine and its emissions of preheated bio diesel.

  5. Diagnosing laser-preheated magnetized plasmas relevant to magnetized liner inertial fusion

    Science.gov (United States)

    Harvey-Thompson, A. J.; Sefkow, A. B.; Nagayama, T. N.; Wei, M. S.; Campbell, E. M.; Fiksel, G.; Chang, P.-Y.; Davies, J. R.; Barnak, D. H.; Glebov, V. Y.; Fitzsimmons, P.; Fooks, J.; Blue, B. E.

    2015-12-01

    We present a platform on the OMEGA EP Laser Facility that creates and diagnoses the conditions present during the preheat stage of the MAGnetized Liner Inertial Fusion (MagLIF) concept. Experiments were conducted using 9 kJ of 3ω (355 nm) light to heat an underdense deuterium gas (electron density: 2.5 ×1020 cm-3=0.025 of critical density) magnetized with a 10 T axial field. Results show that the deuterium plasma reached a peak electron temperature of 670 ± 140 eV, diagnosed using streaked spectroscopy of an argon dopant. The results demonstrate that plasmas relevant to the preheat stage of MagLIF can be produced at multiple laser facilities, thereby enabling more rapid progress in understanding magnetized preheat. Results are compared with magneto-radiation-hydrodynamics simulations, and plans for future experiments are described.

  6. MINLP model for simultaneous scheduling and retrofit of refinery preheat train

    Directory of Open Access Journals (Sweden)

    Zulkafli N. Izyan, M. Noryani, Abdul H. Dayanasari, M. Shuhaimi

    2014-01-01

    Full Text Available There is greater awareness today on the depleting fossil energy resources and the growing problem of atmospheric pollution. Engineers are developing practical techniques to ensure energy processes are designed and operated efficiently. Inefficient heat exchangers lead to higher fuel demand and higher carbon emission. This paper presents mixed-integer nonlinear programming (MINLP model for simultaneous cleaning and retrofit of crude preheat train (CPT in oil refinery plant. The formulation of the model is generated and coded in General Algebraic Modeling System (GAMS. The model minimizes the cost of energy and the cost of cleaning. The model takes into account the changes in fouling rates throughout time. There are two cases for this study. The cases are online cleaning (Case 1 and simultaneous online cleaning and retrofit (Case 2. The largest energy saving are found in Case 2. The installation of high efficiency heat exchangers improves furnace inlet temperature (FIT from 215oC to 227oC. Furthermore, Case 2 results in the highest percentage of cost saving by about 59%. The payback period for investment in high efficiency heat exchangers is 5 months. Thus, Case 2 is the most cost effective option for reductions of energy consumption in Crude Distillation Unit (CDU.

  7. Preheating of the early universe by radiation from high-mass X-ray binaries

    Science.gov (United States)

    Sazonov, S. Yu.; Khabibullin, I. I.

    2017-04-01

    Using a reliablymeasured intrinsic (i.e., corrected for absorption effects) present-day luminosity function of high-mass X-ray binaries (HMXBs) in the 0.25-2 keV energy band per unit star formation rate, we estimate the preheating of the early Universe by soft X-rays from such systems. We find that X-ray irradiation, mainly executed by ultraluminous and supersoft ultraluminous X-ray sources with luminosity L X > 1039 erg s-1, could significantly heat ( T > T CMB, where T CMB is the temperature of the cosmic microwave background) the intergalactic medium by z 10 if the specific X-ray emissivity of the young stellar population in the early Universe was an order of magnitude higher than at the present epoch (which is possible due to the low metallicity of the first galaxies) and the soft X-ray emission from HMXBs did not suffer strong absorption within their galaxies. This makes it possible to observe the 21 cm line of neutral hydrogen in emission from redshifts z < 10.

  8. Simulation of Pellet Ablation

    Science.gov (United States)

    Parks, P. B.; Ishizaki, Ryuichi

    2000-10-01

    In order to clarify the structure of the ablation flow, 2D simulation is carried out with a fluid code solving temporal evolution of MHD equations. The code includes electrostatic sheath effect at the cloud interface.(P.B. Parks et al.), Plasma Phys. Contr. Fusion 38, 571 (1996). An Eulerian cylindrical coordinate system (r,z) is used with z in a spherical pellet. The code uses the Cubic-Interpolated Psudoparticle (CIP) method(H. Takewaki and T. Yabe, J. Comput. Phys. 70), 355 (1987). that divides the fluid equations into non-advection and advection phases. The most essential element of the CIP method is in calculation of the advection phase. In this phase, a cubic interpolated spatial profile is shifted in space according to the total derivative equations, similarly to a particle scheme. Since the profile is interpolated by using the value and the spatial derivative value at each grid point, there is no numerical oscillation in space, that often appears in conventional spline interpolation. A free boundary condition is used in the code. The possibility of a stationary shock will also be shown in the presentation because the supersonic ablation flow across the magnetic field is impeded.

  9. The effect of radiofrequency thermal ablation method on nasal mucociliary activity in patients with inferior turbinate hypertrophy.

    Science.gov (United States)

    Uz, Ali Osman; Kenar, Fethullah; Yıldız, Hüseyin; Duran, Abidin; Tekin, Mustafa Said; Ayçiçek, Abdullah

    2014-01-01

    This study aims to investigate the effect of radiofrequency thermal ablation (RFTA) treatment on nasal mucociliary activity before and after treatment in inferior turbinate hypertrophy. Thirty-nine patients (21 males, 18 females; mean age 36.3±13.9 years; range 16 to 67 years) admitted to our clinic with complaint of nasal obstruction and diagnosed with stromal inferior turbinate hypertrophy were included in this study. Effect of RFTA treatment on nasal mucociliary activity was investigated by saccharine test before treatment and two months after treatment. Grade of nasal obstruction was evaluated by visual analog scale (VAS) before treatment and two months after treatment. Results were compared with paired t-test. Mean mucociliary activity times were 9.8±4.4 minutes before treatment and 9.6±4.1 minutes two months after treatment, and the difference between two tests was not statistically significant (p=0.3). Mean VAS scores for nasal obstruction were 6.5±1.2 before treatment and 3.8±1.0 two months after treatment, and the difference between two results was statistically significant (p=0.001). Difference between sexes in terms of saccharine transit time and VAS values before and after treatment was not statistically significant (p>0.05). It was detected that RFTA has no adverse effect on mucociliary activity in the treatment of inferior turbinate hypertrophy, and this method is notably effective in relieving the nasal obstruction caused by inferior turbinate hypertrophy.

  10. The Effects of Microwave Ablation and Surgical Resection on Hematogenous Dissemination of Cancer Cells in Treating Patients with Small Primary Hepatocellular Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Chaoyang Wen; Baowei Dong; Ping Liang; Xiaoling Yu; Li Su; Dejiang Yu; Hongtian Xia

    2006-01-01

    OBJECTIVE To conduct a comparative study of the effects of treatment using microwave ablation versus surgical resection on hematogenous dissemination of cancer cells, and on the level of immune cells of the peripheral blood in patients with small primary hepatocellular carcinoma (PHC, ≤5 cm).METHODS Forty patients with small PHC (maximal diameter ≤5 cm) were divided into a microwave group (19 cases) and a surgical operation group (21 cases). A real-time (RT) quantitative nested RT-PCR examination was performed for peripheral blood alpha-fetoprotein (AFP) mRNA. Studies were conducted to determine the level of CD3, CD4, CD8 and CD4/CD8 cells and for liver function at 30 min before, and 30 min,1 day and 3 days after the treatment.RESULTS Compared to the value before ablation, no obvious changes of CD3, CD4, CD8 and CD4/CD8 cells were found in patients of the microwave group within 7 days after ablation, but CD3, CD4 and CD4/CD8 cells in the operation group were lower compared to that before operatioh. The copy number of AFP mRNA in the peripheral blood samples of the patients of the 2 groups before operation was determined in 67.5% of the patients (27/40). There was an rise in the expression after treatment but no statistical difference was found in comparing the 2 groups. Follow-up of the patients was conducted for 1 to 16 months. For patients with continuous expression of peripheral blood AFP mRNA, the possibility of relapse and metastasis was increased.CONCLUSION Surgical resection or microwave ablation can cause more exfoliation of hepatoma carcinoma cells in the peripheral blood of patients with small PHC. The immune function of peripheral blood cells decreased in the patients after surgical resection, however, the immune function was better protected following microwave ablation. Microwave ablation causes minor reduction in liver function, and the treatment method presents a definite value for PHC therapy.

  11. Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative.

    Science.gov (United States)

    Espinosa-Muñoz, E; Ramírez-Ocaña, D; Martín-García, A M; Ruiz-García, F J; Puentes-Zarzuela, C

    The case is presented of a 3 year-old girl with mitochondrial disease (subacute necrotizing encephalomyelopathy of Leigh syndrome), v-stage chronic kidney disease of a diffuse mesangial sclerosis, as well as developmental disorders, and diagnosed with hyperthyroidism Graves-Basedow disease. Six weeks after starting the treatment with neo-carbimazole, the patient reported a serious case of agranulocytosis. This led to stopping the anti-thyroid drugs, and was treated successfully with (131)I ablation therapy. The relevance of the article is that Graves' disease is uncommon in the paediatric age range (especially in children younger than 6 years old), and developing complications due to a possible late diagnosis. Agranulocytosis as a potentially serious adverse effect following the use of anti-thyroid drugs, and the few reported cases of ablation therapy with (131)I at this age, makes this case unique. Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

  12. Recombinant human TSH and ablation of post-surgical thyroid remnants in differentiated thyroid cancer: the effect of pre-treatment with furosemide and furosemide plus lithium

    Energy Technology Data Exchange (ETDEWEB)

    Barbaro, Daniele; Lapi, Paola; Pasquini, Cristina; Orsini, Paola; Turco, Anna [General Hospital of Livorno, Endocrinology Unit, Livorno (Italy); Grosso, Mariano; Boni, Giuseppe; Mariani, Giuliano [University of Pisa Medical School, Regional Center of Nuclear Medicine, Pisa (Italy); Meucci, Giuseppe [General Hospital of Livorno, Division of General Surgery, Livorno (Italy); Marzola, Maria Cristina; Rubello, Domenico [' Santa Maria della Misericordia' Hospital, Department of Nuclear Medicine, PET Centre, Rovigo (Italy); Berti, Piero; Miccoli, Paolo [University of Pisa Medical School, Department of Surgery, Pisa (Italy)

    2010-02-15

    Recombinant human TSH (rhTSH) can be used for post-surgical radioiodine (I-131) thyroid remnants ablation in differentiated thyroid cancer (DTC) patients after surgery. Debate exists in literature about the optimal amount of I-131 that should be given for obtaining an effective ablation and about the role of iodine pool during treatment. Therefore, the aim of the present study was to assess whether I-131 ablation during rhTSH stimulus can be improved by reducing the circulating iodine pool and by increasing thyroid cell uptake and retention of I-131 obtained by administering furosemide and lithium. A total of 201 consecutive DTC patients were entered in the study: they were treated by total thyroidectomy and I-131 therapy during rhTSH stimulus to ablate thyroid remnants. Patients were divided into two groups according to the TNM stage: group 1 included patients in stage I-II who were treated with a low 30-mCi I-131 dose, while group 2 included patients in stage III-IV who were treated by a high 100-mCi I-131 dose. Moreover, both groups were further subdivided into three subgroups. Subgroup (a) included 45 patients from group 1 and 22 from group 2: they were treated with I-131 under rhTSH stimulus, following a short 4-day withdrawal of L-thyroxine (LT4). Subgroup (b) included 45 patients from group 1 and 22 from group 2: they were treated with I-131 under rhTSH stimulus, following a short 4-day withdrawal of L-T4, and after furosemide administration (25 mg/day orally) during the 3 days before I-131. Subgroup (c) included 45 patients from group 1 and 22 from group 2: they were treated with I-131 under rhTSH stimulus, following a short 4-day L-T4 withdrawal, and after administration of furosemide (25 mg/day orally) during the 3 days prior I-131 and lithium (450 mg/day orally) during the 3 days following I-131. Another group (group 3) of 20 patients characterized by a very low-risk cancer (unifocal tumor <1.0 cm in diameter, without extra-capsular extension, N0) was

  13. Effectiveness of combined (131)I-chTNT and radiofrequency ablation therapy in treating advanced hepatocellular carcinoma.

    Science.gov (United States)

    Tu, Jianfei; Ji, Jiansong; Wu, Fazong; Wang, Yonghui; Zhang, Dengke; Zhao, Zhongwei; Ying, Xihui

    2015-03-01

    To investigate the effectiveness of monoclonal antibody ((131)I-chTNT) and radiofrequency ablation (RFA) combination therapy in treating middle-advanced stage hepatocellular carcinoma (HCC). Thirty-four patients diagnosed with HCC patients, divided into two groups comprised of 22 and 12 cases were included in this retrospective study. The two groups received RFA with or without ((131)I-chTNT) therapy, respectively. The patients in these groups were followed up for a median of 31 and 35 months, respectively. Patient survival was evaluated using Kaplan-Meier method and safety profiles were determined by analyzing liver, thyroid, and bone marrow toxicities. This retrospective study showed that survival time of the patients who received combination therapy was significantly longer than that of the RFA group (P = 0.052). The median progress-free survival of patients in the two groups was 23 and 7 months, respectively, and the difference was significant (P = 0.04). Tumor recurred in 3.5-8.7 months in four of the combination group patients, among which three had newly developed lesions. The red blood cells and platelets counts were not altered on day 7 and 1 month of the treatment, however, number of white blood cells was significantly increased on day 7 which was reversed back to the normal range in 2 weeks. The ALT and AST were also not significantly altered on day 7 and 1 month of therapy. In middle-advanced stage HCC patients, the combination of (131)I-chTNT and RFA therapy was found to be significantly more effective than the RFA treatment alone as assessed in short-term follow-up. However, the dose we used was insufficient to completely block the local recurrence of the lesions with a diameter of 5 cm or larger.

  14. Analysis of infrared laser tissue ablation

    Science.gov (United States)

    McKenzie, Gordon P.; Timmerman, Brenda H.; Bryanston-Cross, Peter J.

    2005-04-01

    The mechanisms involved in infrared laser tissue ablation are studied using a free electron laser (FELIX) in order to clarify whether the increased ablation efficiency reported in literature for certain infrared wavelengths is due to a wavelength effect or to the specific pulse structure of the lasers that are generally used in these studies. Investigations are presented of ablation of vitreous from pigs" eyes using several techniques including protein gel electrophoresis and ablation plume visualization. The ablation effects of three different infrared wavelengths are compared: 3 mm, which is currently in clinical surgical use, and the wavelengths associated with the amide I and amide II bands, i.e. 6.2 mm and 6.45mm, respectively. The results suggest a different ablation mechanism to be in operation for each studied wavelength, thus indicating that the generally reported increased ablation efficiency in the 6-6.5 micron range is due to the wavelength rather than the typical free electron laser pulse structure.

  15. Laser ablation principles and applications

    CERN Document Server

    1994-01-01

    Laser Ablation provides a broad picture of the current understanding of laser ablation and its many applications, from the views of key contributors to the field. Discussed are in detail the electronic processes in laser ablation of semiconductors and insulators, the post-ionization of laser-desorbed biomolecules, Fourier-transform mass spectroscopy, the interaction of laser radiation with organic polymers, laser ablation and optical surface damage, laser desorption/ablation with laser detection, and laser ablation of superconducting thin films.

  16. Structure and morphologies of ZnO nanoparticles synthesized by pulsed laser ablation in liquid: Effects of temperature and energy fluence

    Energy Technology Data Exchange (ETDEWEB)

    Guillén, G. García; Palma, M.I. Mendivil [Universidad Autónoma de Nuevo León, Facultad de Ingeniería Mecánica y Eléctrica, San Nicolás de los Garza, Nuevo León 66455 (Mexico); Krishnan, B. [Universidad Autónoma de Nuevo León, Facultad de Ingeniería Mecánica y Eléctrica, San Nicolás de los Garza, Nuevo León 66455 (Mexico); Universidad Autónoma de Nuevo León – Centro de Innovación, Investigación y Desarrollo de Ingeniería y Tecnología, Apodaca, Nuevo León 66600 (Mexico); Avellaneda, D.; Castillo, G.A.; Roy, T.K. Das [Universidad Autónoma de Nuevo León, Facultad de Ingeniería Mecánica y Eléctrica, San Nicolás de los Garza, Nuevo León 66455 (Mexico); and others

    2015-07-15

    Zinc oxide nanoparticles were prepared by pulsed laser ablation of a zinc metal target at different water temperatures (room temperature, 50, 70 and 90 °C). Ablation was carried out using 532 nm output from a pulsed (10 ns, 10 Hz) Nd:YAG laser at three different laser fluence. Analysis of the morphology, crystalline phase, elemental composition, optical and luminescent properties were done using Transmission Electron Microscopy (TEM), X-Ray Photoelectron Spectroscopy (XPS), UV–visible absorption spectroscopy and photoluminescence spectroscopy. TEM analysis showed that a change in temperature resulted in ZnO and Zn(OH){sub 2} nanoparticles with different sizes and morphologies. XPS results confirmed the compositions and chemical states of these nanoparticles. These zinc nanomaterials showed emission in the ultraviolet (UV) and blue regions. The results of this work demonstrated that by varying the liquid medium temperature, the structure, composition, morphology and optical properties of the nanomaterials could be modified during pulsed laser ablation in liquid. - Graphical abstract: Display Omitted - Highlights: • Zinc nanomaterial colloids were synthesized by PLAL. • Effects of laser fluence and the distilled water temperature were analyzed. • The final structure varied with the distilled water temperature and laser fluence. • The morphology was dependent on the distilled water temperature and laser fluence. • Zinc nanocolloids showed emission in the UV and blue region.

  17. Study of sensitivity change of OSL signals from quartz and feldspars as a function of preheat temperature

    DEFF Research Database (Denmark)

    Jungner, H.; Bøtter-Jensen, L.

    1994-01-01

    Optically stimulated luminescence (OSL) signals from feldspar and quartz samples were studied using infrared (860 nm) and green light (420-575 nm) stimulation. A serious problem connected with the regeneration technique used for dating is associated with a change of OSL sensitivity to radiation...... in the couse of the measurement process. A typical effect seen is a large increase of the apparent strength of our beta source when calibrated against a gamma source. If the regeneration procedure is used, it is shown that the sensitivity increases up to similar to 50% during the measurement process...... and as a result, the equivalent dose (ED) would be underestimated. A study of sensitivity changes in feldspars and quartz was carried out with emphasis on the effect of preheat and annealing on the OSL signal. Measurement results obtained are presented, and possible elimination of errors in dating caused...

  18. Randomised Comparison of Costs and Cost-Effectiveness of Cryostripping and Endovenous Laser Ablation for Varicose Veins : 2-Year Results

    NARCIS (Netherlands)

    Disselhoff, B. C. V. M.; Buskens, E.; Kelder, J. C.; Kinderen, D. J. der; Moll, F. L.

    2009-01-01

    Background: Although endovenous laser ablation for varicose veins is replacing surgical stripping, proper economic evaluation with adequate follow-up in a randomised clinical trial is important for considered policy decisions regarding the implementation of new techniques. Methods: Data from a rando

  19. Enhanced coupling of optical energy during liquid-confined metal ablation

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyun Wook, E-mail: wkang@pknu.ac.kr [Department of Biomedical Engineering, Pukyong National University, Busan, South Korea and Center for Marine-integrated Biomedical Technology (MIBT), Pukyong National University, Busan (Korea, Republic of); Welch, Ashley J. [Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712 (United States)

    2015-10-21

    Liquid-confined laser ablation was investigated with various metals of indium, aluminum, and nickel. Ablation threshold and rate were characterized in terms of surface deformation, transient acoustic responses, and plasma emissions. The surface condition affected the degree of ablation dynamics due to variations in reflectance. The liquid confinement yielded up to an order of larger ablation crater along with stronger acoustic transients than dry ablation. Enhanced ablation performance resulted possibly from effective coupling of optical energy at the interface during explosive vaporization, plasma confinement, and cavitation. The deposition of a liquid layer can induce more efficient ablation for laser metal processing.

  20. Hydrodynamic modeling of ns-laser ablation

    Directory of Open Access Journals (Sweden)

    David Autrique

    2013-10-01

    Full Text Available Laser ablation is a versatile and widespread technique, applied in an increasing number of medical, industrial and analytical applications. A hydrodynamic multiphase model describing nanosecond-laser ablation (ns-LA is outlined. The model accounts for target heating and mass removal mechanisms as well as plume expansion and plasma formation. A copper target is placed in an ambient environment consisting of helium and irradiated by a nanosecond-laser pulse. The effect of variable laser settings on the ablation process is explored in 1-D numerical simulations.

  1. Ablation response testing of aerospace power supplies

    Science.gov (United States)

    Lutz, S. A.; Chan, C. C.

    1993-01-01

    An experimental program was performed to assess the aerothermal ablation response of aerospace power supplies. Full-scale General Purpose Heat Source (GPHS) test articles, Graphite Impact Shell (GIS) test articles, and Lightweight Radioisotope Heater Unit (LWRHU) test articles were all tested without nuclear fuel in simulated reentry environments at the NASA Ames Research Center. Stagnation heating, stagnation pressure, stagnation surface temperature, stagnation surface recession profile, and weight loss measurements were obtained for diffusion-limited and sublimation ablation conditions. The recession profile and weight loss measurements showed an effect of surface features on the stagnation face. The surface features altered the local heating which in turn affected the local ablation.

  2. Effect of ultrasound combined with laparoscopic radiofrequency ablation on liver function and immunological function in patients with liver cancer

    Institute of Scientific and Technical Information of China (English)

    Xin Li

    2016-01-01

    Objective:To explore the effect of ultrasound combined with laparoscopic radiofrequency ablation (LRFA) on the liver function and immunological function in patients with liver cancer. Methods: A total of 76 patients with liver cancer who were admitted in our hospital were included in the study and randomized into the treatment group and the control group with 38 cases in each group. The patients in the treatment group were given ultrasound in combined with LRFA, while the patients in the control group were given TACE. The changes of liver function and immunological function indicators before and after treatment in the two groups were compared.Results: The serum AST, ALT, T-BIL, and D-BIL after operation in the two groups were significantly reduced when compared with before operation (P<0.05); moreover, the reduced degree in the treatment group was significantly lower than that in the control group (P<0.05). The plasma IgG, IgA, and IgM levels after operation in the two groups were significantly elevated when compared with before operation (P<0.05), and the difference between the two groups was statistically significant (P<0.05). CD3+, CD4+, CD8+, and NK levels after operation in the two groups were significantly elevated when compared with before operation (P<0.05), while CD4+/CD8+ was significantly reduced when compared with before operation (P<0.05); moreover, the difference between the two groups was statistically significant (P<0.05).Conclusions:Ultrasound combined with LRFA in the treatment of liver cancer can protect the liver function and immunological function; therefore, it can be served as a preferred scheme.

  3. Spectroscopic characterization approach to study surfactants effect on ZnO 2 nanoparticles synthesis by laser ablation process

    Science.gov (United States)

    Drmosh, Q. A.; Gondal, M. A.; Yamani, Z. H.; Saleh, T. A.

    2010-05-01

    Zinc peroxide nanoparticles having grain size less than 5 nm were synthesized using pulsed laser ablation in aqueous solution in the presence of different surfactants and solid zinc target in 3% H 2O 2. The effect of surfactants on the optical and structure of ZnO 2 was studied by applying different spectroscopic techniques. Structural properties and grain size of the synthesized nanoparticles were studied using XRD method. The presence of the cubic phase of zinc peroxide in all samples was confirmed with XRD, and the grain sizes were 4.7, 3.7, 3.3 and 2.8 nm in pure H 2O 2, and H 2O 2 mixed with SDS, CTAB and OGM respectively. For optical characterization, FTIR transmittance spectra of ZnO 2 nanoparticles prepared with and without surfactants show a characteristic ZnO 2 absorption at 435-445 cm -1. FTIR spectrum revealed that the adsorbed surfactants on zinc peroxide disappeared in case of CTAB and OGM while it appears in case of SDS. This could be due to high critical micelles SDS concentration comparing with others which is attributed to the adsorption anionic nature of this surfactant. Both FTIR and UV-vis spectra show a red shift in the presence of SDS and blue shift in the presence of CTAB and OGM. The blue shift in the absorption edge indicates the quantum confinement property of nanoparticles. The zinc peroxide nanoparticles prepared in additives-free media was also characterized by Raman spectra which show the characteristic peaks at 830-840 and 420-440 cm -1.

  4. Spectroscopic characterization approach to study surfactants effect on ZnO{sub 2} nanoparticles synthesis by laser ablation process

    Energy Technology Data Exchange (ETDEWEB)

    Drmosh, Q.A. [Laser Research Group, Physics Department, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Gondal, M.A., E-mail: magondal@kfupm.edu.sa [Laser Research Group, Physics Department, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Yamani, Z.H. [Laser Research Group, Physics Department, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Saleh, T.A. [Center of Excellence in Nanotechnology (CENT), King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia)

    2010-05-01

    Zinc peroxide nanoparticles having grain size less than 5 nm were synthesized using pulsed laser ablation in aqueous solution in the presence of different surfactants and solid zinc target in 3% H{sub 2}O{sub 2}. The effect of surfactants on the optical and structure of ZnO{sub 2} was studied by applying different spectroscopic techniques. Structural properties and grain size of the synthesized nanoparticles were studied using XRD method. The presence of the cubic phase of zinc peroxide in all samples was confirmed with XRD, and the grain sizes were 4.7, 3.7, 3.3 and 2.8 nm in pure H{sub 2}O{sub 2}, and H{sub 2}O{sub 2} mixed with SDS, CTAB and OGM respectively. For optical characterization, FTIR transmittance spectra of ZnO{sub 2} nanoparticles prepared with and without surfactants show a characteristic ZnO{sub 2} absorption at 435-445 cm{sup -1}. FTIR spectrum revealed that the adsorbed surfactants on zinc peroxide disappeared in case of CTAB and OGM while it appears in case of SDS. This could be due to high critical micelles SDS concentration comparing with others which is attributed to the adsorption anionic nature of this surfactant. Both FTIR and UV-vis spectra show a red shift in the presence of SDS and blue shift in the presence of CTAB and OGM. The blue shift in the absorption edge indicates the quantum confinement property of nanoparticles. The zinc peroxide nanoparticles prepared in additives-free media was also characterized by Raman spectra which show the characteristic peaks at 830-840 and 420-440 cm{sup -1}.

  5. Low-energy electron irradiation of preheated and gas-exposed single-wall carbon nanotubes

    Science.gov (United States)

    Ecton, P. A.; Beatty, J.; Verbeck, G.; Lakshantha, W.; Rout, B.; Perez, J. M.

    2016-11-01

    We investigate the conditions under which electron irradiation at 2 keV of single-wall carbon nanotube (SWCNT) bundles produces an increase in the Raman D peak. We find that irradiation of SWCNTs that are preheated in situ at 600 °C for 1 h in ultrahigh vacuum before irradiation does not result in an increase in the D peak. Irradiation of SWCNTs that are preheated in vacuum and then exposed to air or gases results in an increase in the D peak, suggesting that adsorbates play a role in the increase in the D peak. Small diameter SWCNTs that are not preheated or preheated and then exposed to air show a significant increase in the D and G bands after irradiation. X-ray photoelectron spectroscopy shows no chemical shifts in the C 1s peak of SWCNTs that have been irradiated versus SWCNTs that have not been irradiated, suggesting that chemisorption of adsorbates is not responsible for the increase in the D peak.

  6. Area 3, SRC-II coal slurry preheater studies report for the technical data analysis program

    Energy Technology Data Exchange (ETDEWEB)

    1984-08-01

    This report reviews the raw data gathered from the Preheater B test runs at Ft. Lewis, and also the Preheater B results presented in the Solvent Refined Coal (SRC) Process Final Report, Volumes 1 and 2 of Slurry Preheater Design, SRC-II Process and the Ft. Lewis Slurry Preheater Data Analysis, 1 1/2 Inch Coil by Gulf Science and Technology Corporation of Pittsburgh, Pennsylvania. attempts were made to correlate several variables not previously considered with slurry viscosity and thermal conductivity. Only partial success was realized. However, in the process of attempting to correlate these variables an understanding of why some variables could not be correlated was achieved. An attempt was also made, using multiple linear regression, to correlate coal slurry viscosity and thermal conductivity with several independent variables among which were temperature, coal concentration, total solids, coal type, slurry residence time, shear rate, and unit size. The final correlations included some, but not all, of these independent variables. This report is not a stand alone document and should be considered a supplement to work already done. It should be read in conjunction with the reports referenced above.

  7. Abstract of a report on reducing resistance in gas-fired preheaters

    Energy Technology Data Exchange (ETDEWEB)

    1939-04-27

    The demands of Hydro-works Scholven to increase the capacity of one of their preheaters, with consequently greater volume of circulating gases, inspired the idea to study the resistance to the flow of gases in the preheaters. The resistance varied with the square of the velocity, so that pressure differences beyond the capacity of the single-stage Schiele blowers could be easily developed. It was intended, therefore, to determine the exact course of the pressure loss in preheaters in operation at Scholven. Since this met with many practical difficulties, it was supplemented by measurements on sheet steel models built to one-tenth their actual size. The measurements on the preheaters already in service showed that the pressure loss in the heating chamber proper, that is the pressure losses applicable to heat transmission, were small compared to the total pressure loss. The greatest proportion of the heating loss occurred in the inlet and outlet ducts and passages. This indicated that particular attention must be paid to the resistance in the ducts and the distributing points. The gas distribution needed to be arranged such that energy-consuming dampers could be eliminated. Where bends could not be avoided, guide vanes could considerably reduce the pressure loss. It was suggested to use an Escher--Weiss axial blower system instead of the Schiele radial blower. Reduction of pressure losses would increase velocity of the gases in the heating flues and thus increase heat transmission in the hairpin coils.

  8. System Performance Measurement Supports Design Recommendations for Solar Ventilation Preheat System (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-08-01

    Technical briefing to report the outcomes of a data monitoring effort to determine the nature of solar vent preheat system performance problems at a U.S. military installation. The analysis reports up-to-date research and findings regarding system design, helping to clarify the issue as a factor of system design, rather than a shortcoming of SVP systems.

  9. Little evidence for non-gravitational energy feedback beyond $r_{500}$ - An end to ICM preheating?

    CERN Document Server

    Iqbal, Asif; Nath, Biman B; Ettori, Stefano; Eckert, Dominique; Malik, Manzoor A

    2016-01-01

    Non-gravitational feedback affects the nature of the intra-cluster medium (ICM). X-ray cooling of the ICM and in situ energy feedback from AGN's and SNe as well as preheating of the gas at epochs preceding the formation of clusters are proposed mechanisms for such feedback. While cooling and AGN feedbacks are dominant in cluster cores, the signatures of a preheated ICM are expected to be present even at large radii. To estimate the degree of preheating, with minimum confusion from AGN feedback/cooling, we study the non-gravitational feedback energy profiles upto $r_{200}$ for a sample of 17 galaxy clusters using joint data sets of Planck SZ pressure profiles and ROSAT/PSPC gas density profiles. We show that the estimated energy feedback profile of the ICM is consistent with zero at 1$\\sigma$ beyond $\\sim r_{500}$. The canonical value of preheating energy of 1 keV/particle, needed in order to match energy entropy floors and cluster scalings, is ruled out at $4.4\\sigma$ beyond $r_{500}$. Our results take both n...

  10. Preheating to around 100°C under endcap blocks before welding at KHI.

    CERN Multimedia

    Loveless, D

    2000-01-01

    The 600mm thick sector blocks of the CMS endcaps are made from three layers of 200mm plates welded together. During the manufacture at KHI, the blocks are preheated to around 100°C to prevent cracks in the welds.

  11. Wavelength dependence of soft tissue ablation by using pulsed lasers

    Institute of Scientific and Technical Information of China (English)

    Xianzeng Zhang; Shusen Xie; Qing Ye; Zhenlin Zhan

    2007-01-01

    Pulsed laser ablation of soft biological tissue was studied at 10.6-, 2.94-, and 2.08-μm wavelengths. The ablation effects were assessed by means of optical microscope, the ablation crater depths were measured with reading microscope. It was shown that Er:YAG laser produced the highest quality ablation with clear,sharp cuts following closely the patial contour of the incident beam and the lowest fluence threshold. The pulsed CO2 laser presented the moderate quality ablation with the highest ablation efficiency. The craters drilled with Ho:YAG laser were generally larger than the incident laser beam spot, irregular in shape, and clearly dependent on the local morphology of biotissue. The blation characteristics, including fluence threshold and ablation efficiency, varied substantially with wavelength. It is not evident that water is the only dominant chromophore in tissue.

  12. Effects of renal sympathetic nerve radiofrequency ablation on norepinephrine spillover rate and sympathetic nerve activity in dogs with hypertension

    Directory of Open Access Journals (Sweden)

    Hang YU

    2012-11-01

    Full Text Available Objective  To evaluate the validity and explore the mechanism of renal sympathetic denervation (RSD in the treatment of dogs with hypertension reproduced by constriction of abdominal aorta. Methods  The hypertension model was reproduced by constriction of abdominal aorta in 20 adult healthy dogs. These dogs were then randomly divided into the treatment group and control group (10 each. Renal sympathetic nerve radiofrequency ablation was done in treatment group 1 month after modeling. The foreleg blood pressure, sympathetic activity and norepinephrine overflow rate of dogs in two groups were detected before modeling, and 1, 2 and 3 months after modeling, and the trend of the change was also observed. Results  One month after modeling, the systolic blood pressure (SBP, diastolic blood pressure (DBP and mean arterial blood pressure (MAP were elevated significantly in control group (146.7±21.0, 89.0±12.7 and 108.3±14.9mmHg compared with those before modeling (119.5±13.2, 76.5±7.8 and 90.9±8mmHg, P < 0.05. The renal sympathetic activity impulse and norepinephrine spillover rate were also enhanced significantly (P < 0.05. The renal sympathetic nerve activity obviously decreased in the treatment group after the operation, and then increased 2 months after the ablation. The norepinephrine spillover rate in treatment group increased significantly 1 month after modeling (P < 0.05, and decreased after ablation, and it lasted to the end of the experiment (P < 0.05. One and two months after ablation, the norepinephrine spillover rate was lower in treatment group than in control group (P < 0.05. Conclusion  Renal sympathetic nerve radiofrequency ablation significantly inhibits the elevation of norepinephrine spillover rate and sympathetic nerve activity in dogs with hypertension.

  13. Silicon-Class Ablators for NIC Ignition Capsules

    Science.gov (United States)

    Ho, Darwin; Salmonson, Jay; Haan, Steve

    2012-10-01

    We present design studies using silicon-class ablators (i.e., Si, SiC, SiB6, and SiB14) for NIC ignition capsules. These types of ablators have several advantages in that they: (a) require no internal dopant layers and are robust to M-band radiation; (b) have smooth outer surfaces; (c) have stable fuel-ablator interface; and (d) have good 1-D performance. The major disadvantage for some of the ablators in this class is the relatively smaller ablation stabilization. Consequently, the ablator is more susceptible to breakup caused by RT instabilities. However, smoother outer surfaces on this class of ablators can reduce the effect of RT instabilities. 2-D simulations of SiC ablators show ignition failure despite smooth surfaces and good 1-D performance. But SiB6 and SiB14 ablators exhibit promising behaviors. SiB6 (SiB14) ablators have high 1-D ignition margin and high peak core hydrodynamic pressure 880 (900) Gbar. The ablation scale length for SiB6 is longer than that for SiC and for SiB14 is comparable to that of plastic. Therefore, we expect acceptable performance for SiB6 and less RT growth for SiB14. 2-D simulations are now in progress.

  14. Reversal effect of sulpiride on rotational behaviour of rats with unilateral frontal cortex ablation: an alternative explanation for the pharmacological mechanism of its antidepressant effect.

    Science.gov (United States)

    Kaneno, S; Fukamauchi, F; Komatsu, H; Koyama, K; Ikawa, K

    2001-02-01

    The antidepressant effect of sulpiride has been generally explained as the result of its preferential blocking effect on self-inhibitory presynaptic dopamine autoreceptors at low doses. Low dose haloperidol has the same blocking effect. In rats with unilateral ablation of the frontal cortex, methamphetamine administration induced mild contralateral rotation 10 days after the operation. We examined whether low dose sulpiride and haloperidol would have the same effect on this rotational model. High dose sulpiride (100 mg/kg) or low dose haloperidol (0.05 mg/kg) prevented this methamphetamine-induced rotation. However, low dose (15 mg/kg) sulpiride clearly reversed the direction of rotation. This reversal effect of low dose sulpiride is not explained by the preferential blocking effect on dopamine autoreceptors. The results suggest that low dose sulpiride, unlike low dose haloperidol, has a prominent blocking effect on D2 receptors in the frontal cortex. This unique effect of sulpiride may be relevant to its clinical antidepressant and anxiolytic effects at low doses.

  15. Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

    OpenAIRE

    Yue, Wen-Wen; Li, Xiao-Long; Xu, Hui-Xiong; Lu, Feng; Sun, Li-Ping; Guo, Le-Hang; He, Ya-Ping; Wang, Dan; Yin, Zhi-Qiang

    2016-01-01

    This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary ...

  16. Ablation enhancement of silicon by ultrashort double-pulse laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Xin; Shin, Yung C. [Center for Laser-Based Manufacturing, School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907 (United States)

    2014-09-15

    In this study, the ultrashort double-pulse ablation of silicon is investigated. An atomistic simulation model is developed to analyze the underlying physics. It is revealed that the double-pulse ablation could significantly increase the ablation rate of silicon, compared with the single pulse ablation with the same total pulse energy, which is totally different from the case of metals. In the long pulse delay range (over 1 ps), the enhancement is caused by the metallic transition of melted silicon with the corresponding absorption efficiency. At ultrashort pulse delay (below 1 ps), the enhancement is due to the electron excitation by the first pulse. The enhancement only occurs at low and moderate laser fluence. The ablation is suppressed at high fluence due to the strong plasma shielding effect.

  17. Effects of radiation on direct-drive laser target interaction

    Science.gov (United States)

    Colombant, D. G.

    1999-11-01

    Radiation may be useful for reducing laser imprint and Rayleigh-Taylor (RT) growth in direct-drive target pellets. We will discuss the important role of radiation in a proposed direct-drive X-ray preheated target concept(S.Bodner et al., Phys. Plasmas 5,1901(1998)). In this design, a high-Z coating surrounds a thin plastic coat, over a DT-wicked foam and on top of the DT fuel. Radiation effects will be examined and discussed in the context of this design. The soft X-ray radiation emitted during the foot of the laser pulse - at a few 10^12W/cm^2- preheats the foam ablator which contributes to the reduction of the RT instability. The ablator also stops the radiation, allowing the fuel to stay on a low adiabat. Radiation in the blow-off corona of the target establishes a long scalelength plasma. This separates the ablation region from the laser absorption region where the remaining defects in laser uniformity/pellet surface finish constitute the seed for hydrodynamic instabilities. However, when the pulse intensity rises, the pressure generated by the laser in combination with the changing opacity of the plasma causes the plasma to be pushed back toward the ablator. This is called a Radiative Plasma Structure (RPS)(J.Dahlburg et al., J.Q.S.R.T. 54,113(1995)). These RPS's are a potential problem because they may carry with them the imprint which was present in the low-density corona. We will show and discuss these various effects, as well as some of the experimental work(C.Pawley et al., this conference) under way in connection with this program. These experiments are essential in order to validate both the design concepts and the numerical models, which include on-line state-of-the-art atomic physics modeling(M.Klapisch et al.,Phys. Plasmas 5,1919(1998)).

  18. Effect of high-frequency positive-pressure ventilation on halothane ablation of hypoxic pulmonary vasoconstriction.

    Science.gov (United States)

    Hall, S M; Chapleau, M; Cairo, J; Levitzky, M G

    1985-08-01

    High-frequency positive-pressure ventilation (HFPPV) was compared to intermittent positive-pressure ventilation (IPPV) during unilateral atelectasis with and without halothane anesthesia. Dogs with electromagnetic flow probes chronically implanted on their main (Qt) and left (Ql) pulmonary arteries were ventilated via Carlen's dual-lumen endotracheal tubes. In eight closed-chest dogs, about 43% of the cardiac output perfused the left lung during bilateral ventilation by either a Harvard animal respirator (IPPV) or a Health-dyne model 300 high-frequency ventilator (HFPPV). Unilateral atelectasis decreased blood flow (Ql/Qt) to that lung. Ql/Qt was 19 +/- 1% with HFPPV during left-lung atelectasis and right-lung ventilation, compared to 32 +/- 1% with unilateral IPPV. This suggests that HFPPV permits stronger hypoxic pulmonary vasoconstriction. Addition of 1% halothane increased blood flow to the atelectatic left lung during unilateral ventilation with IPPV but not with HFPPV. This suggests that halothane decreases the effects of hypoxic pulmonary vasoconstriction during conventional ventilation but not during HFPPV.

  19. Microwave Ablation Using Four-Tine Antenna: Effects of Blood Flow Velocity, Vessel Location, and Total Displacement on Porous Hepatic Cancer Tissue

    Science.gov (United States)

    Chaichanyut, Montree

    2016-01-01

    This research is concerned with microwave ablation analyses using a 2.45 GHz four-tine (4T) antenna for hepatic cancer tissue. In the study, three-dimensional finite-element models were utilized to examine the tissue temperature distributions during and after MW ablation. A preliminary study was first carried out with regard to the specific absorption rates along the 4T antenna insertion depths and the temperature distributions inside the solid and porous liver models with either 3 cm-in-diameter tumor or 5 cm-in-diameter tumor. Based on the preliminary results, the porous models were further examined for the effect of varying blood flow velocities (0–200 cm/s) with a 1 cm-in-diameter blood vessel next to the antenna and also for the effect of vessel-antenna locations (0, 0.8, and 1.3 cm) with a constant blood flow velocity of 16.7 cm/s. All scenarios were simulated under temperature-controlled mode (90°C). The findings revealed that the blood flow velocity and vessel location influence the ablation effectiveness and that increased blood flow inhibits heat transfer to the vessel wall. At the nearest and farthest vessel-antenna locations (0 and 1.3 cm), approximately 90.3% and 99.55% of the cancer cells were eradicated except for the areas adjacent to the vessel. In addition, total tissue thermal displacement is 5.9 mm which is 6.59% of the total length of the overall model. PMID:27642364

  20. Microwave Ablation Using Four-Tine Antenna: Effects of Blood Flow Velocity, Vessel Location, and Total Displacement on Porous Hepatic Cancer Tissue

    Directory of Open Access Journals (Sweden)

    Montree Chaichanyut

    2016-01-01

    Full Text Available This research is concerned with microwave ablation analyses using a 2.45 GHz four-tine (4T antenna for hepatic cancer tissue. In the study, three-dimensional finite-element models were utilized to examine the tissue temperature distributions during and after MW ablation. A preliminary study was first carried out with regard to the specific absorption rates along the 4T antenna insertion depths and the temperature distributions inside the solid and porous liver models with either 3 cm-in-diameter tumor or 5 cm-in-diameter tumor. Based on the preliminary results, the porous models were further examined for the effect of varying blood flow velocities (0–200 cm/s with a 1 cm-in-diameter blood vessel next to the antenna and also for the effect of vessel-antenna locations (0, 0.8, and 1.3 cm with a constant blood flow velocity of 16.7 cm/s. All scenarios were simulated under temperature-controlled mode (90°C. The findings revealed that the blood flow velocity and vessel location influence the ablation effectiveness and that increased blood flow inhibits heat transfer to the vessel wall. At the nearest and farthest vessel-antenna locations (0 and 1.3 cm, approximately 90.3% and 99.55% of the cancer cells were eradicated except for the areas adjacent to the vessel. In addition, total tissue thermal displacement is 5.9 mm which is 6.59% of the total length of the overall model.

  1. Comparative Effects of Dexmedetomidine and Propofol on US-Guided Radiofrequency Ablation of Hepatic Neoplasm Under Monitored Anesthesia Care

    OpenAIRE

    2015-01-01

    Abstract Percutaneous radiofrequency ablation (RFA) is a useful and safe procedure for treating hepatic neoplasm. However, liver RFA causes severe pain, which thereby increases the demand for monitored anesthesia care (MAC). Here, we compared the efficacy and safety of propofol and dexmedetomidine, which are commonly administered during MAC when performing RFA to assess hepatic neoplasm. In this randomized controlled trial, 40 patients were randomly allocated to 2 groups for elective RFA. Pat...

  2. Photography of shock waves during excimer laser ablation of the cornea. Effect of helium gas on propagation velocity.

    Science.gov (United States)

    Krueger, R R; Krasinski, J S; Radzewicz, C; Stonecipher, K G; Rowsey, J J

    1993-07-01

    Shadow photography of shock waves excited by means of a xenon chloride excimer laser was performed to determine the shock wave propagation velocity in air, nitrogen and helium. Energy densities between 500 and 2,000 mJ/cm2 were used to ablate a rotating rubber cylindrical target and porcine corneas. In ablating the rubber cylinder, a shock wave velocity of 3.3 km/s was generated in air and nitrogen at 40 ns; this decreased to 1.4 km/s at 320 ns. When helium was blown on the target, the velocity increased by a factor of approximately two, to 5.9 km/s at 40 ns and 2.7 km/s at 320 ns. We suggest that blowing helium on the surface of the cornea during excimer laser ablation may speed the dissipation of high-energy acoustic waves and gaseous particles, and thus reduce the exposure and transfer of heat energy to the surrounding tissue.

  3. 热物理性能对高硅氧/酚醛复合材料烧蚀性能的影响%Effect of thermal physical properties on ablation properties of high silica/phenolic composite

    Institute of Scientific and Technical Information of China (English)

    时圣波; 梁军; 方国东

    2011-01-01

    根据高硅氧/酚醛复合材料的烧蚀机理,建立了包括烧蚀退移层、化学反应边界层、液态层、炭化层、热解层、原始材料层的自外向内的物理模型,针对平板烧蚀问题,预报了热导率、比定压热容、驻点焓值等热物理性能对高硅氧/酚醛复合材料的表面烧蚀后退率、壁面温度、气化烧蚀速率、热阻塞效应因子、气化分数等烧蚀性能的影响.结果表明,低热导率能使表面烧蚀后退率明显降低,但却使壁面温度、热阻塞效应因子及材料的气化分数升高;而高的比定压热容则能大大降低表面烧蚀后退率和壁面温度;随驻点焓值的增加,表面烧蚀后退率和壁面温度都增大.%According to ablation mechanism of high silica/phenolic composite, a physical model, considering ablation recession layer, chemical reaction boundary layer, liquid layer, charring layer, pyrolytic layer and original material layer, was established successively. For the flat plate ablation problem, the effect of the thermal physical properties, such as coefficient of thermal conductivity, specific heat capacity at constant pressure and stagnation enthalpy, on the ablation properties was studied. The ablation properties were embodied by the surface ablation recession rate, wall temperature, gasification ablation rate, thermal blockade effect factor and gasification fraction. The predicted results show that surface ablation recession rate decreases dramatically with the decrease of coefficient of thermal conductivity, while wall temperature, thermal blockade effect factor and gasification fraction increase reversely. The large specific heat capacity at constant pressure can decrease surface ablation recession rate and wall temperature greatly. Surface ablation recession rate and wall temperature increase with the increase of the stagnation enthalpy.

  4. Mechanism and effects of complex laser ablation%激光复合损伤机理与效应研究

    Institute of Scientific and Technical Information of China (English)

    程勇; 朱孟真; 马云峰; 魏靖松; 刘旭; 丁方正; 谭朝勇; 陈霞; 郭延龙

    2016-01-01

    For antimissile, antisatellite, or such kind of strategic defense application, laser weapon is expected to emit 100 kW power or higher level. By considering the development and its object of laser weapon, a new damnification method using multi-mode laser was presented. Using the lasers, different in wavelength, pulsed and continuous wave, frequency verified, focused on target commutatively or synchronously to get more effective result. A complex damnification model was conceived and simulated by using finite element method. A 2 kW continuous wave laser and a long pulse width laser were used in the damage comparison experiments. Both the simulation and experiments results indicate that pulsed laser is better than continuous in metal ablation, furthermore, complex laser is much better. Comparing with pulsed laser, complex laser inspires "nonlinear avalanche ablation" effect, which makes the ablated metal 13 times more than using pulsed laser. This "nonlinear avalanche ablation" effect makes a base for"multi-mode coaxial combined" laser weapon.%达到或者超过100 kW的激光输出是激光武器用于反导反卫等战略防御的终极发展目标.基于激光武器发展目标与最新动向,提出了多模式激光复合损伤新思路,即采用不同波长、连续与脉冲、频率变化的激光,同时或交替作用在同一靶材上,获得更好的损伤效果.构建了脉冲/连续激光复合损伤物理模型,并用有限元法进行了仿真模拟,使用2 kW连续激光器与10 J长脉冲激光器开展了损伤对比实验.模拟和实验结果表明,脉冲激光烧蚀金属靶材效果优于连续激光;在两种激光复合或交替作用下出现"非线性雪崩烧蚀"效应,复合烧蚀效果明显优于脉冲激光,烧蚀质量是脉冲激光的13倍.这一效应,为战术激光武器向"合束多模式同轴输出"新体制发展提供了基础.

  5. Moldable cork ablation material

    Science.gov (United States)

    1977-01-01

    A successful thermal ablative material was manufactured. Moldable cork sheets were tested for density, tensile strength, tensile elongation, thermal conductivity, compression set, and specific heat. A moldable cork sheet, therefore, was established as a realistic product.

  6. Ablation of steel using picosecond laser pulses in burst mode

    Science.gov (United States)

    Lickschat, Peter; Demba, Alexander; Weissmantel, Steffen

    2017-02-01

    Results obtained in picosecond laser processing of steel applying the burst mode are presented. Using the burst mode, pulse trains, i.e., bursts, consisting of a number of picosecond pulses with an inter-pulse delay of 12.5 ns and 10 ps pulse duration are applied for material processing. Small cavities with sizes in the range of the laser beam diameter made by single-burst ablation are compared to quadratic cavities of 0.5 × 0.5 mm² produced by multiburst ablation and simultaneous scanning of the laser beam across the steel sample surface. The ablated volume per pulse within the burst was calculated either from the ablated volume per burst or from the ablation depth of the quadratic cavities. With the second to fourth pulses in the bursts, a reduction of the ablated volume per pulse in comparison with the first pulse in the bursts (i.e., to the use of single pulses) was found for both single- and multiburst ablation, which is assumed to be due to plasma shielding. By contrast, the ablated volume per pulse within the bursts increases for the fifth to eighth pulses. Heat accumulation effect and the influence of the heated plasma can be assumed to be the reason for these higher ablation rates. SEM micrographs also show that there is a higher melt ejection out of the laser processed area. This is indicated by the formation of bulges about the ablated area.

  7. Comparison of the effectiveness of one- and two-suture prosthesis used to correct left laryngeal hemiplegia in the equine: followed by Nd:YAG laser ventricle ablation

    Science.gov (United States)

    Burnett, Cindy; Tate, Lloyd P.; Correa, Maria T.

    1992-06-01

    The effectiveness of one or two suture prothesis in performing laryngoplasty was compared. Forty-six horses treated for left laryngeal hemiplegia at North Carolina State University, College of Veterinary Medicine (NCSU-CVM) between January 1987 and April 1991 were included in the study. Thirty-seven of the horses were treated with two sutures, while nine were treated with one suture. All horses, after recovering from general anesthesia, were sedated the following day and were subjected to a transendoscopic neodymium: yttrium aluminum garnet (Nd:YAG) laser ablation of the left laryngeal ventricle. Ability to perform after treatment relative to before treatment, reduction or elimination of respiratory noise, owner or trainer satisfaction, were compared for the two suture prosthetic procedures using chi-squared test or Fisher's exact test. No statistical significant differences were found for performance, reduction of noise, and owner or trainer satisfaction. The use of one or two sutures seemed to have no effect on the effectiveness of prosthetic laryngoplasty procedure followed by Nd:YAG ventricular ablation.

  8. An observational feasibility study to assess the safety and effectiveness of intranasal fentanyl for radiofrequency ablations of the lumbar facet joints

    Science.gov (United States)

    Bartoszek, Michael W; McCoart, Amy; Hong, Kyung-soo Jason; Haley, Chelsey; Highland, Krista Beth; Plunkett, Anthony R

    2017-01-01

    Purpose The purpose of the present observational, feasibility study is to assess the preliminary safety and effectiveness of intranasal fentanyl for lumbar facet radiofrequency ablation procedures. Patients and methods This cohort observational study included 23 adult patients. Systolic and diastolic blood pressures, heart rate, oxygen saturation percent, Pasero Opioid-Induced Sedation Scale score, and the Defense and Veterans Pain Rating Scale pain score were assessed prior to the procedure and intranasal fentanyl (100 μg) administration and every 15 minutes after administration, up to 60 minutes post administration. Follow-up of patient satisfaction with pain control and treatment was assessed 24 hours after discharge. The primary outcome was safety as evidenced by adverse events. Secondary outcomes included the above-mentioned vital signs and pain ratings. Results No adverse events occurred in the present study and all participants maintained an acceptable level of awareness throughout the assessment period. One-way repeated measures analyses of covariance tests with Bonferroni-adjusted means indicated that oxygen saturation, blood pressure, and heart rate changed from baseline, whereas pain scores were lower at post-administration levels compared with baseline. Finally, the majority of participants reported being satisfied with pain control and treatment. Conclusion Preliminary evidence indicates that intranasal fentanyl is safe and effective for lumbar facet radiofrequency ablation procedures. Future rigorous randomized control trials are needed to confirm the present results and to examine the effects of intranasal fentanyl on intraoperative and postoperative opioid use.

  9. femtosecond laser ablation

    OpenAIRE

    Margetic, Vanja

    2003-01-01

    Femtosecond laser ablation was investigated as a solid sampling method for elemental chemical analysis. In comparison to the sampling with longer laser pulses, two aspects could be improved by using ultrashort pulses: elimination of the elemental fractionation from the ablation crater, which is necessary for an accurate quantitative analysis, and better control of the material removal (especially for metals), which increases the spatial resolution of microanalysis. Basic aspects of ultrashort...

  10. Glue septal ablation: A promising alternative to alcohol septal ablation

    Directory of Open Access Journals (Sweden)

    Sercan Okutucu

    2016-03-01

    Full Text Available Hypertrophic cardiomyopathy (HCM is defined as myocardial hypertrophy in the absence of another cardiac or systemic disease capable of producing the magnitude of present hypertrophy. In about 70% of patients with HCM, there is left ventricular outflow tract (LVOT obstruction (LVOTO and this is known as obstructive type of hypertrophic cardiomyopathy (HOCM. Cases refractory to medical treatment have had two options either surgical septal myectomy or alcohol septal ablation (ASA to alleviate LVOT gradient. ASA may cause some life-threatening complications including conduction disturbances and complete heart block, hemodynamic compromise, ventricular arrhythmias, distant and massive myocardial necrosis. Glue septal ablation (GSA is a promising technique for the treatment of HOCM. Glue seems to be superior to alcohol due to some intrinsic advantageous properties of glue such as immediate polymerization which prevents the leak into the left anterior descending coronary artery and it is particularly useful in patients with collaterals to the right coronary artery in whom alcohol ablation is contraindicated. In our experience, GSA is effective and also a safe technique without significant complications. GSA decreases LVOT gradient immediately after the procedure and this reduction persists during 12 months of follow-up. It improves New York Heart Association functional capacity and decrease interventricular septal wall thickness. Further studies are needed in order to assess the long-term efficacy and safety of this technique.

  11. Differential Effects of C1qa Ablation on Glaucomatous Damage in Two Sexes in DBA/2NNia Mice.

    Directory of Open Access Journals (Sweden)

    Ruma Kumari

    Full Text Available To determine the sex and age-related effects of C1qa ablation on retinal ganglion cell (RGC and optic nerve (ON axonal loss in a mouse model of glaucomatous neurodegeneration.Congenic C1qa mice were generated in the DBA/2NNia background. Female and male knockout (-/-, heterozygous (+/-, and wild type (+/+ mice were aged up to 14 months and IOPs were recorded in a subset of animals. Retinas of mice from all three groups at 5-6, 9-10 and 11-13 months of age were flat-mounted after retrograde labeling with Fluorogold. Imaged retinas were scored (RGC score semi-quantitatively on a 10 point scale by two independent observers. A subset of retinas and optic nerves were also used for measurement of total number of RGCs. Semi-thin sections of ON were imaged and graded (ON score for the amount of axonal damage semi-quantitatively, by two masked observers. Analysis of covariance (ANCOVA was used for statistical comparisons. Microglial cells in flat-mounted retinas of 5-6 month old C1qa -/- and C1qa +/+ mice were used for assessment of microglial activation utilizing morphological criteria.Female C1qa -/- mice had significantly higher IOP (p<0.000001, ANOVA between 8 and 13 months of age compared to C1qa +/+ animals. No differences in IOPs between animals of the three genotypes were observed in males. At 5-6 months of age, there was no difference in RGC or ON scores between the three genotypes in animals of either sex. At 9-10 months of age, female mice didn't show significant differences in RGC or ON scores between the three genotypes. However, male C1qa -/- and C1qa +/- mice of the same age had better RGC and ON scores (p<0.003 and p<0.05, ANCOVA, for RGC and ON scores, respectively compared with C1qa +/+ mice. At 11-13 months of age, female C1qa -/- mice had better RGC scores (p<0.006, ANCOVA compared to C1qa +/+ and C1qa +/- animals. Accordingly, C1qa -/- mice had higher RGC counts (p<0.03, t-test compared to C1qa +/+ animals. In male mice, there was a

  12. Influence of the Previous Preheating Temperature on the Static Coefficient of Friction with Lubrication

    Directory of Open Access Journals (Sweden)

    M. Živković

    2016-12-01

    Full Text Available Experimental investigations static coefficient of friction in lubricated conditions and pre-heating of the sample pin at high temperatures is discussed in this paper. The static coefficient of friction was measured in the sliding steel copper pins per cylinder of polyvinylchloride. Pins are previously heated in a special chamber from room temperature to a temperature of 800 oC with a step of 50 °C. Tribological changes in the surface layer of the pins caused by pre-heating the pins at high temperatures and cooling systems have very significantly influenced the increase in the coefficient of static friction. The results indicate the possibility of improving the friction characteristics of metal materials based on their thermal treatment at elevated temperatures.

  13. Experimental investigations of the laser cladding of protective coatings on preheated base material

    Science.gov (United States)

    Jendrzejewski, Rafal; Sliwinski, Gerard; Conde, Ana; Navas, Carmen; de Damborenea, Juan J.

    2004-06-01

    The laser cladding technique was applied to obtain Co-based stellite SF6 coatings on the chromium steel base. The coatings were prepared by means of a direct cladding of metal powder using a 1.2 kW cw CO2 laser stand with a controlled preheating of the substrate material. Results of the metallographic tests revealed a fine-grained, dendritic microstructure and proper metallic bonding between substrate and coating. A nearly constant concentration of mian elements at different areas of the coating cross-section indicated on homogeneous chemical composition of the laser-cladded SF6 alloy samples. A significant decrease of the micro-crack number with increasing temperature of the base preheating was observed. This was accompanied by a drop of the wear and corrosion resistance.

  14. Gravitational Waves from Abelian Gauge Fields and Cosmic Strings at Preheating

    CERN Document Server

    Dufaux, Jean-Francois; Garcia-Bellido, Juan

    2010-01-01

    Primordial gravitational waves provide a very important stochastic background that could be detected soon with interferometric gravitational wave antennas or indirectly via the induced patterns in the polarization anisotropies of the cosmic microwave background. The detection of these waves will open a new window into the early Universe, and therefore it is important to characterize in detail all possible sources of primordial gravitational waves. In this paper we develop theoretical and numerical methods to study the production of gravitational waves from out-of-equilibrium gauge fields at preheating. We then consider models of preheating after hybrid inflation, where the symmetry breaking field is charged under a local U(1) symmetry. We analyze in detail the dynamics of the system in both momentum and configuration space, and show that gauge fields leave specific imprints in the resulting gravitational wave spectra, mainly through the appearence of new peaks at characteristic frequencies that are related to...

  15. Specific Angular Momentum Distribution of Disc Galaxies Formed in Preheated Intergalactic Media

    Institute of Scientific and Technical Information of China (English)

    LUO Zhi-Jian; FU Li-Ping; SHU Cheng-Gang

    2004-01-01

    Assuming that baryons within a galactic halo have the same specific angular momentum as the dark matter where they locate initially and a disc forms due to the gas cooling and condensation with the conservation of angular momentum, we investigate the angular momentum distribution in a resulting galactic disc under the new preheated galaxy formation model suggested by Mo and Mao (Mon. Not. R. Astron. Soc. 333 (2002) 768).Compared with the observational results, it can be concluded that the preheated galaxy formation model can match current observations. This model can be a good approach to solve the problems of both the angular momentum catastrophe and the mismatch of angular-momentum profiles in current disc galaxy formation models.

  16. Electronically Controlling the System of Preheating Intake Air by Flame for Diesel Engine Cold-Start

    Institute of Scientific and Technical Information of China (English)

    杜巍; 赵福堂

    2003-01-01

    In order to improve the cold-start performance of heavy duty diesel engine, electronically controlling the preheating of intake air by flame was researched. According to simulation and thermodynamic analysis about the partial working processes of the diesel engine, the amount of heat energy, enough to make the fuel self-ignite at the end of compression process at different temperatures of coolant and intake-air, was calculated. Several HY20 preheating plugs were used to heat up the intake air. Meanwhile, an electronic control system based on 8 bit micro-controller unit (MCS-8031) was designed to automatically control the process of heating intake air. According to the various temperatures of coolant and ambient air, one plug or two plugs can automatically be selected to heat intake air. The demo experiment validated that the total system could operate successfully and achieve the scheduled function.

  17. Percutaneous thermal ablation of renal neoplasms; Perkutane Thermoablation von Nierentumoren

    Energy Technology Data Exchange (ETDEWEB)

    Tacke, J. [Inst. fuer Diagnostische und Interventionelle Radiologie/Neuroradiologie, Klinikum Passau (Germany); Mahnken, A.H.; Guenther, R.W. [Klinik fuer Radiologische Diagnostik, Universitaetsklinikum Aachen (Germany)

    2005-12-15

    Due to modern examination techniques such as multidetector computed tomography and high-field magnetic resonance imaging, the detection rate of renal neoplasms is continually increasing. Even though tumors exceeding 4 cm in diameter rarely metastasize, all renal lesions that are possible neoplasms should be treated. Traditional treatment techniques include radical nephrectomy or nephron-sparing resection, which are increasingly performed laparoscopically. Modern thermal ablation techniques such as hyperthermal techniques like radiofrequency ablation RFA, laser induced thermal ablation LITT, focused ultrasound FUS and microwave therapy MW, as well as hypothermal techniques (cryotherapy) may be a useful treatment option for patients who are unfit for or refuse surgical resection. Cryotherapy is the oldest and best known thermal ablation technique and can be performed laparoscopically or percutaneously. Since subzero temperatures have no antistyptic effect, additional maneuvers must be performed to control bleeding. Percutaneous cryotherapy of renal tumors is a new and interesting method, but experience with it is still limited. Radiofrequency ablation is the most frequently used method. Modern probe design allows volumes between 2 and 5 cm in diameter to be ablated. Due to hyperthermal tract ablation, the procedure is deemed to be safe and has a low complication rate. Although there are no randomized comparative studies to open resection, the preliminary results for renal RFA are promising and show RFA to be superior to other thermal ablation techniques. Clinical success rates are over 90% for both, cryo- and radiofrequency ablation. Whereas laser induced thermal therapy is established in hepatic ablation, experience is minimal with respect to renal application. For lesions of more than 2 cm in diameter, additional cooling catheters are required. MR thermometry offers temperature control during ablation. Microwave ablation is characterized by small ablation volumes

  18. Preheating Cold Gas Thruster Flow Through a Thermal Energy Storage Conversion System

    Science.gov (United States)

    2013-01-01

    Journal Article 3. DATES COVERED (From - To) January 2013- October 2013 4. TITLE AND SUBTITLE Preheating Cold Gas Thruster Flow Through a Thermal Energy... Gas Thruster Flow through a Thermal Energy Storage Conversion System Michael R. Reid1 United States Air Force, Colorado Springs, CO, 80840 David B...specific impulse relative to a cold gas flow. Electric propulsion systems, the primary competitor to solar thermal propulsion systems, rely on the rather

  19. Inductive Preheating in Laser Beam Welding of Multimaterial Joints of 22MnB5 and AA6016

    Science.gov (United States)

    Kügler, H.; Vollertsen, F.

    Inductive preheating is well known as possibility to heat ferromagnetic materials. In brazing preheating causes an improvement of wetting quality, e.g. smaller wetting angles and longer wetting lengths. In this paper inductive preheating is used to support a laser beam hybrid joining process. Aluminum AA6016 is molten in order to wet the surface of AlSi- coated steel 22MnB5. Investigations on the influence of preheating on wetting characteristics and intermetallic phase seam formation were carried out. Strength values up to 230 MPa have been measured in tensile shear tests. Fraction zone occurs in the aluminum base material indicating uncritical thickness of the intermetallic phase seam at the interface.

  20. Marginal and internal analysis of preheated dental fissure-sealing materials using optical coherence tomography.

    Science.gov (United States)

    Borges, Boniek Castillo Dutra; de Assunção, Isauremi Vieira; de Aquino, Célia Avani; de Melo Monteiro, Gabriela Queiroz; Gomes, Anderson Stevens Leonidas

    2016-02-01

    This study aimed to evaluate the influence of pre-photoactivation temperature on the marginal and internal integrity (occurrence of voids) of fissure-sealing materials on occlusal fissures using optical coherence tomography (OCT). Occlusal fissures of 40 human third molars were sealed using a resin-based fissure sealant (Fluroshield) and a flowable composite (Permaflo) photoactivated at 68 °C (preheated) or at room temperature (25 °C) (n=10). After sealing, the teeth were subjected to thermocycling (500 cycles, 5-55 °C) and 14 days of pH cycling (demineralisation for 6 hours/day and remineralisation for 18 hours/day). The occlusal surfaces were scanned in a buccolingual direction, and 20 tomographic images parallel to the long axis of each tooth were obtained. Images presenting marginal gaps and internal voids were counted and statistically analysed using analysis of variance and Tukey's test (Pinternal voids than the resin-based sealant. Preheated materials had a lower percentage of gaps and internal voids than the materials at room temperature. Therefore, preheated flowable composite provided the best marginal sealing of fissures, and internal homogeneity of the material. © 2015 FDI World Dental Federation.

  1. Influence of ageing, grinding and preheating on the thermal behaviour of alpha-lactose monohydrate.

    Science.gov (United States)

    Garnier, S; Petit, S; Mallet, F; Petit, M-N; Lemarchand, D; Coste, S; Lefebvre, J; Coquerel, G

    2008-09-01

    It is shown that the onset temperature and the magnitude of thermal events observed during DSC analyses of alpha-lactose monohydrate can be strongly affected by various treatments such as ageing, manual grinding and preheating (cycle of preliminary dehydration and rehydration). In the case of grinding and preheating, the change of dehydration pathways was further investigated by using a suitable combination of characterization techniques, including X-ray powder diffraction (XRPD) performed with a synchrotron source (allowing an accurate Rietveld analysis), scanning electron microscopy (SEM), laser particle size measurements, FTIR spectroscopy and (1)H NMR for the determination of beta-lactose contents in samples. It appeared that the dehydration mechanism is affected not only by a smaller particle size distribution, but also by residual anisotropic lattice distortions and by the formation of surface defects or high energy surfaces. The fusion-recrystallization process occurring between anhydrous forms of alpha-lactose at ca. 170 degrees C is not significantly affected by grinding, whereas a preheating treatment induces an unexpected large increase of the enthalpy associated with this transition. Our observations and interpretations confirm the important role of water molecules in the crystal cohesion of the title compound and illustrate the necessity to consider the history of each sample for a satisfactory understanding of the physical properties and the behaviour of this important pharmaceutical excipient.

  2. 空气预热器的改造%Revamping of air preheater

    Institute of Scientific and Technical Information of China (English)

    廖艳玲

    2011-01-01

    The revamping of air preheater in the waste heat recovery system of a 4.1 MM TPY diesel hy-drotreating unit in SINOPEC Qingdao Refining & Chemical Co. , Ltd. Was introduced. An analysis was performed on how to revamp the air preheater to reduce flue gas emission temperature of waste heat recovery system so as to improve the thermal efficiency of fired heaters. After revamping, the flue gas emission temperature is about 30 ℃ lower than that before the revamping, the thermal energy obtained by the air is much higher than that before replacement of pre-heater tubes and energy saving is significant.%介绍了中国石化青岛炼油化工有限责任公司余热回收系统的空气预热器的改造情况,分析了如何通过对空气预热器的改造来降低余热回收系统排烟温度,从而提高加热炉的热效率.改造后,烟气排烟温度比改造前降低30℃左右,空气所获得的能量比更换热管前有较大提高,节能效果显著.

  3. Laser Pre-Heat Studies for MagLIF with Z-Beamlet

    Science.gov (United States)

    Geissel, Matthias; Harvey-Thompson, Adam J.; Awe, T. J.; Gomez, M. R.; Harding, E.; Jennings, C.; Kimmel, M. W.; Knapp, P.; Peterson, K.; Schollmeier, M.; Sefkow, A. B.; Shores, J. E.; Sinars, D. B.; Slutz, S. A.; Smith, I. C.; Speas, C. S.; Vesey, R. A.; Porter, J. L.; Campbell, E. M.; Lewis, S. M.

    2015-11-01

    Magnetized Liner Inertial Confinement Fusion (MagLIF) relies on strong pre-heat of the fuel, typically hundreds of eV. Z-Beamlet delivers up to 4 kJ of laser energy to the target to achieve this goal. Over the last year, several experimental campaigns at the Pecos target area of Sandia's Z-Backlighter Facility and in the center section of the Z-Accelerator have been performed to investigate pre-heat. Primary objectives of these campaigns were the transmission through the laser entrance hole (LEH) in dependence of window thicknesses and focus parameters (including phase plate smoothing), as well as energy coupling to the gaseous fuel. The applied diagnostic suite included a wide range of time integrated and time-resolved X-ray imaging devices, spectrometers, backscatter monitors, a full-beam laser transmission calorimeter, and X-ray diodes.We present the findings of these studies, looking ahead towards a standard pre-heat platform. Sandia National Labs is a multi-program laboratory managed and operated by Sandia Corp., a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Dept. of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  4. Study of laser preheat in magnetic liner inertial fusion using the AMR code FLASH

    Science.gov (United States)

    Adams, Marissa; Jennings, Christopher; Slutz, Stephen; Peterson, Kyle; Gourdain, Pierre-Alexandre; University of Rochester; Sandia National Laboratories Collaboration

    2016-10-01

    Magnetic Liner Inertial Fusion (MagLIF) on the Z Pulsed Power Accelerator involves three processes: magnetization, preheat, and compression. An issue with this scheme is the development of instabilities during laser preheat, where the Z-Beamlet laser system may not deposit energy into deuterium fuel uniformly. This study explores potential mixing between liner and fuel, and inner imprinting of seeds on a beryllium liner that may generate late instability growth and shear, using the Eulerian AMR code FLASH. We further investigate potential instability implications of an additional layer of deuterium-tritium ice, as has been proposed and assess the sensitivity of MagLIF implosions to axial variations in fuel preheat; meanwhile testing the expediency of FLASH for these scenarios. FLASH was developed in part by the DOE NNSA ASC and DOE Office of Science ASCR-supported Flash Center at the University of Chicago. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin comapny, for the U.S. Department of Energy's National Nuclear Security Administration under contract No. DE-AC04-94AL85000.

  5. Analysis of the effect of renal excretory system cooling during thermal radiofrequency ablation in an animal model

    OpenAIRE

    Andre Meireles; Khaled Ahmed Taha Neto; Lisias Nogueira Castilho; Giuseppe D'Ippolito; Leonardo Oliveira Reis

    2014-01-01

    Objective: Analysis of renal excretory system integrity and efficacy of radiofrequency ablation with and without irrigation with saline at 2 degrees C (SF2). Materials and Methods: The median third of sixteen kidneys were submitted to radiofrequency (exposition of 1 cm) controlled by intra-surgical ultrasound, with eight minutes cycles and median temperature of 90 degrees C in eight female pigs. One excretory renal system was cooled with SF2, at a 30ml/min rate, and the other kidney was not. ...

  6. Effect of Surgical Atrial Fibrillation Ablation at the Time of Cardiac Surgery on Risk of Postoperative Pacemaker Implantation.

    Science.gov (United States)

    El-Chami, Mikhael F; Binongo, José Nilo G; Levy, Mathew; Merchant, Faisal M; Halkos, Michael; Thourani, Vinod; Lattouf, Omar; Guyton, Robert; Puskas, John; Leon, Angel R

    2015-07-01

    The aim of this study was to retrospectively investigate whether performing surgical atrial fibrillation (AF) ablation in conjunction with cardiac surgery (CS) increases the risk for postoperative permanent pacemaker (PPM) requirement. The 30-day risk for PPM requirement was analyzed in consecutive patients who underwent CS from January 2007 to August 27, 2013. Patients were divided into 3 groups: (1) those who underwent AF ablation concomitant with CS (AF ABL), (2) patients with any history of AF who underwent surgery who did not undergo ablation (AF NO ABL), and (3) those with no histories of AF who underwent surgery (NO AF). Logistic regression analysis was performed adjusting for age, gender, and surgery type. Of 13,453 CS patients, 353 (3%) were in the AF ABL group, 1,701 (12%) in the AF NO ABL group, and 11,399 (85%) in the NO AF group. A total of 7,651 patients (57%) underwent coronary artery bypass grafting, 4,384 (33%) underwent valve surgery, and 1,418 (10%) underwent coronary artery bypass grafting and valve surgery. The overall PPM risk was 1.6% (212 of 13,453); risk was 5.7% (20 of 353) in the AF ABL group, 3.1% (53 of 1,701) in the AF NO ABL group, and 1.2% (139 of 11,399) in the NO AF group. The unadjusted and adjusted odds of PPM were higher in the AF ABL and AF NO ABL groups than in the NO AF group (adjusted odds ratio [OR] 2.7, 95% confidence interval [CI] 1.7 to 4.4, and adjusted OR 1.7, 95% CI 1.2 to 2.4, respectively). The unadjusted OR comparing the AF ABL group and the AF NO ABL group was significant (unadjusted OR 1.9, 95% CI 1.9 to 3.2); however, the OR adjusted for surgery type, age, and gender showed a trend toward significance (adjusted OR 1.6, 95% CI 0.9 to 2.7). In conclusion, in this large cohort of patients who underwent CS, surgical AF ablation appeared to carry an increased risk for postoperative PPM implantation. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Ultraviolet excimer laser ablation: the effect of wavelength and repetition rate on in vivo guinea pig skin

    Energy Technology Data Exchange (ETDEWEB)

    Morelli, J.; Kibbi, A.G.; Farinelli, W.; Boll, J.; Tan, O.T.

    1987-06-01

    Multiple dermatologic conditions that are currently treated with traditional cold-knife surgery are amenable to laser therapy. The ideal surgical treatment would be precise and total removal of abnormal tissue with maximal sparing of remaining structures. The ultraviolet (UV) excimer laser is capable of such precise tissue removal due to the penetration depth of 193 nm and 248 nm irradiation of 1 micron per pulse. This type of ablative tissue removal requires a high repetition rate for efficient lesional destruction. Excimer laser radiation at 193 nm is capable of high repetition rates, which are necessary while 248 nm radiation causes increasing nonspecific thermal injury as the laser repetition rate is increased.

  8. Modeling of multi-burst mode pico-second laser ablation for improved material removal rate

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Wenqian; Shin, Yung C.; King, Galen [Purdue University, Center for Laser-based Manufacturing, School of Mechanical Engineering, West Lafayette, IN (United States)

    2010-02-15

    This paper deals with the unique phenomena occurring during the multi-burst mode picosecond (ps) laser ablation of metals through modeling and experimental studies. The two-temperature model (TTM) is used and expanded to calculate the ablation depth in the multi-burst mode. A nonlinear increment of ablation volume is found during the multi-burst laser ablation. The deactivation of ablated material and the application of temperature-dependent electron-phonon coupling are demonstrated to be important to provide reliable results. The simulation results based on this expanded laser ablation model are experimentally validated. A significant increase of ablation rate is found in the multi-burst mode, compared with the single-pulse mode under the same total fluence. This numerical model provides a physical perspective into the energy transport process during multi-burst laser ablation and can be used to study the pulse-to-pulse separation time effect on the ablation rate. (orig.)

  9. Modeling of multi-burst mode pico-second laser ablation for improved material removal rate

    Science.gov (United States)

    Hu, Wenqian; Shin, Yung C.; King, Galen

    2010-02-01

    This paper deals with the unique phenomena occurring during the multi-burst mode picosecond (ps) laser ablation of metals through modeling and experimental studies. The two-temperature model (TTM) is used and expanded to calculate the ablation depth in the multi-burst mode. A nonlinear increment of ablation volume is found during the multi-burst laser ablation. The deactivation of ablated material and the application of temperature-dependent electron-phonon coupling are demonstrated to be important to provide reliable results. The simulation results based on this expanded laser ablation model are experimentally validated. A significant increase of ablation rate is found in the multi-burst mode, compared with the single-pulse mode under the same total fluence. This numerical model provides a physical perspective into the energy transport process during multi-burst laser ablation and can be used to study the pulse-to-pulse separation time effect on the ablation rate.

  10. Lesion dimensions during temperature-controlled radiofrequency catheter ablation of left ventricular porcine myocardium: impact of ablation site, electrode size, and convective cooling

    DEFF Research Database (Denmark)

    Høgh Petersen, H; Chen, X; Pietersen, A

    1999-01-01

    It is important to increase lesion size to improve the success rate for radiofrequency ablation of ischemic ventricular tachycardia. This study of radiofrequency ablation, with adjustment of power to approach a preset target temperature, ie, temperature-controlled ablation, explores the effect...

  11. An Optimized Energy Management Strategy for Preheating Vehicle-Mounted Li-ion Batteries at Subzero Temperatures

    Directory of Open Access Journals (Sweden)

    Tao Zhu

    2017-02-01

    Full Text Available This paper presents an optimized energy management strategy for Li-ion power batteries used on electric vehicles (EVs at low temperatures. In low-temperature environments, EVs suffer a sharp driving range loss resulting from the energy and power capability reduction of the battery. Simultaneously, because of Li plating, battery degradation becomes an increasing concern as the temperature drops. All these factors could greatly increase the total vehicle operation cost. Prior to battery charging and vehicle operating, preheating the battery to a battery-friendly temperature is an approach to promote energy utilization and reduce total cost. Based on the proposed LiFePO4 battery model, the total vehicle operation cost under certain driving cycles is quantified in the present paper. Then, given a certain ambient temperature, a target preheating temperature is optimized under the principle of minimizing total cost. As for the preheating method, a liquid heating system is also implemented on an electric bus. Simulation results show that the preheating process becomes increasingly necessary with decreasing ambient temperature, however, the preheating demand declines as driving range grows. Vehicle tests verify that the preheating management strategy proposed in this paper is able to save on total vehicle operation costs.

  12. Excimer laser ablation of thin titanium oxide films on glass

    Energy Technology Data Exchange (ETDEWEB)

    Overschelde, O. van [Condensed Matter Physics Group, University of Mons-Hainaut, B-7000 Mons (Belgium); Dinu, S. [University of ' Valahia' , Targoviste (Romania); Guisbiers, G. [Condensed Matter Physics Group, University of Mons-Hainaut, B-7000 Mons (Belgium); Monteverde, F. [Materia Nova, Unit of Electronic Microscopy, B-7000 Mons (Belgium); Nouvellon, C. [Materia Nova, Inorganic and Analytical Chemistry, B-7000 Mons (Belgium); Wautelet, M. [Condensed Matter Physics Group, University of Mons-Hainaut, B-7000 Mons (Belgium)]. E-mail: michel.wautelet@umh.ac.be

    2006-04-30

    Thin titanium dioxide films are deposited on glass substrates by magnetron sputter deposition. They are irradiated in air, by means of a KrF excimer laser. The ablation rate is measured as a function of the laser fluence per pulse, F, and of the number of pulses, N. Above a fluence threshold, the films are partially ablated. The ablated thickness does not vary linearly with N. This is the signature of a negative feedback between the film thickness and the ablation rate. The origin of this negative feedback is shown to be due to either thermal or electronic effects, or both. At high F, the film detachs from the substrate.

  13. Effects of Various Degrees of Antennal Ablation on Mating and Oviposition Preferences of the Diamondback Moth, Plutella xylostella L.

    Institute of Scientific and Technical Information of China (English)

    YAN Xi-zhong; DENG Cai-ping; SUN Xue-jun; HAO Chi

    2014-01-01

    Using scanning electron microscopy, we investigated the distribution of the trichoid, basiconic, and coeloconic sensilla on the antennae of the diamondback moth (DBM;Plutella xylostella). The trichoid sensilla were the most abundant sensory organ, and the male moth antennae host signiifcantly more trichoid sensilla than female moth antennae. Conversely, basiconic and coeloconic sensilla were found more frequently on female than on male antennae. We performed experiments with various degrees of antennal ablation and demonstrated that DBM antennae played a key role in the control of mating and oviposition. We found that neither oviposition preference nor mating behaviors changed signiifcantly when less than 1/4 of both antennae were removed. However, there was a signiifcant behavioral change when the antennae were ablated by more than half. As the length of the antenna was shortened, the successful mating rate decreased and mating peak was delayed. An otherwise consistent host preference for oviposition was eliminated when both antennae were completely removed. Furthermore, we found that the number of trichoid sensilla was positively correlated with mating rate and oviposition preference. However, the numbers of basiconic and coeloconic sensilla were not correlated with mating rate and mating peak, but highly correlated with oviposition preference. Taken together, our results indicate that antennal sensory information plays a critical role in the mating and oviposition behaviors of this economically important pest.

  14. Liposomal insulin promoter-thymidine kinase gene therapy followed by ganciclovir effectively ablates human pancreatic cancer in mice.

    Science.gov (United States)

    Wu, James X; Liu, Shi-He; Nemunaitis, John J; Brunicardi, F Charles

    2015-04-10

    PDX1 is overexpressed in pancreatic cancer, and activates the insulin promoter (IP). Adenoviral IP-thymidine kinase and ganciclovir (TK/GCV) suppresses human pancreatic ductal carcinoma (PDAC) in mice, but repeated doses carry significant toxicity. We hypothesized that multiple cycles of liposomal IP-TK/GCV ablate human PDAC in SCID mice with minimal toxicity compared to adenoviral IP-TK/GCV. SCID mice with intraperitoneal human pancreatic cancer PANC-1 tumor implants were given a single cycle of 35 µg iv L-IP-TK, or four cycles of 1, 10, 20, 30, or 35 µg iv L-IP-TK (n = 20 per group), followed by intraperitoneal GCV. Insulin and glucose levels were monitored in mice treated with four cycles of 35 µg iv L-IP-TK. We found that four cycles of 10-35 µg L-IP-TK/GCV ablated more PANC-1 tumor volume compared to a single cycle with 35 µg. Mice that received four cycles of 10 µg L-IP-TK demonstrated the longest survival (P SCID mice with minimal toxicity, suggesting non-viral vectors are superior to adenoviral vectors for IP-gene therapy.

  15. Analysis of the effect of renal excretory system cooling during thermal radiofrequency ablation in an animal model

    Directory of Open Access Journals (Sweden)

    Andre Meireles

    2014-01-01

    Full Text Available Objective: Analysis of renal excretory system integrity and efficacy of radiofrequency ablation with and without irrigation with saline at 2 o C (SF2. Materials and Methods: The median third of sixteen kidneys were submitted to radiofrequency (exposition of 1 cm controlled by intra-surgical ultrasound, with eight minutes cycles and median temperature of 90 o C in eight female pigs. One excretory renal system was cooled with SF2, at a 30ml/min rate, and the other kidney was not. After 14 days of post-operatory, the biggest diameters of the lesions and the radiological aspects of the excretory system were compared by bilateral ascending pyelogram and the animals were sacrificed in order to perform histological analysis. Results: There were no significant differences between the diameters of the kidney lesions whether or not exposed to cooling of the excretory system. Median diameter of the cooled kidneys and not cooled kidneys were respectively (in mm: anteroposterior: 11.46 vs. 12.5 (p = 0.23; longitudinal: 17.94 vs. 18.84 (p = 0.62; depth: 11.38 vs. 12.25 (p = 0.47. There was no lesion of the excretory system or signs of leakage of contrast media or hydronephrosis at ascending pyelogram. Conclusion: Cooling of excretory system during radiofrequency ablation does not significantly alter generated coagulation necrosis or affect the integrity of the excretory system in the studied model.

  16. Effect of boron incorporation on the structure and electrical properties of diamond-like carbon films deposited by femtosecond and nanosecond pulsed laser ablation

    Energy Technology Data Exchange (ETDEWEB)

    Sikora, A. [Laboratoire Hubert Curien, UMR 5516 CNRS, Universite Jean Monnet, 18 Rue Pr. Benoit Lauras, 42000 Saint-Etienne (France); Bourgeois, O. [Institut Neel, UPR 2940 CNRS, 25 Avenue des Martyrs, 38042 Grenoble Cedex 9 (France); Sanchez-Lopez, J.C. [Instituto de Ciencia de Materiales de Sevilla, Avda. Americo Vespucio, 49 41092 Sevilla (Spain); Rouzaud, J.-N. [Laboratoire de Geologie, UMR 8538 CNRS, Ecole Normale Superieure, 45 Rue d' Ulm, 75230 Paris Cedex 05 (France); Rojas, T.C. [Instituto de Ciencia de Materiales de Sevilla, Avda. Americo Vespucio, 49 41092 Sevilla (Spain); Loir, A.-S. [Laboratoire Hubert Curien, UMR 5516 CNRS, Universite Jean Monnet, 18 Rue Pr. Benoit Lauras, 42000 Saint-Etienne (France); Garden, J.-L. [Institut Neel, UPR 2940 CNRS, 25 Avenue des Martyrs, 38042 Grenoble Cedex 9 (France); Garrelie, F. [Laboratoire Hubert Curien, UMR 5516 CNRS, Universite Jean Monnet, 18 Rue Pr. Benoit Lauras, 42000 Saint-Etienne (France); Donnet, C., E-mail: christophe.donnet@univ-st-etienne.f [Laboratoire Hubert Curien, UMR 5516 CNRS, Universite Jean Monnet, 18 Rue Pr. Benoit Lauras, 42000 Saint-Etienne (France)

    2009-12-31

    The influence of the incorporation of boron in diamond-like carbon (DLC) films on the microstructure of the coatings has been investigated. The boron-containing DLC films (a-C:B) have been deposited by pulsed laser deposition (PLD) at room temperature in high vacuum conditions, by ablating graphite and boron targets either with a femtosecond pulsed laser (800 nm, 150 fs, fs-DLC) or with a nanosecond pulsed laser (248 nm, 20 ns, ns-DLC). Alternative ablation of the graphite and boron targets has been carried out to deposit the a-C:B films. The film structure and composition have been highlighted by coupling Field Emission Scanning Electron Microscopy, Electron Energy Loss Spectroscopy and High Resolution Transmission Electron Microscopy. Using the B K-edge, EELS characterization reveals the boron effect on the carbon bonding. Moreover, the plasmon energy reveals a tendency of graphitization associated to the boron doping. Pure boron particles have been characterized by HRTEM and reveal that those particles are amorphous or crystallized. The nanostructures of the boron-doped ns-DLC and the boron-doped fs-DLC are thus compared. In particular, the incorporation of boron in the DLC matrix is highlighted, depending on the laser used for deposition. Electrical measurements show that some of these films have potentialities to be used in low temperature thermometry, considering their conductivity and temperature coefficient of resistance (TCR) estimated within the temperature range 160-300 K.

  17. Hard tissue ablation with a spray-assisted mid-IR laser

    Energy Technology Data Exchange (ETDEWEB)

    Kang, H W [American Medical Systems, Minnetonka, MN (United States); Rizoiu, I [BioLase Technology, Irvine, CA (United States); Welch, A J [Department of Biomedical Engineering, University of Texas at Austin, Austin, TX (United States)

    2007-12-21

    The objective of this study was to understand the dominant mechanism(s) for dental enamel ablation with the application of water spray. A free-running Er,Cr:YSGG (yttrium, scandium, gallium, garnet) laser was used to ablate human enamel tissue at various radiant exposures. During dental ablation, distilled water was sprayed on the sample surface, and these results were compared to ablation without a spray (dry ablation). In order to identify dominant ablation mechanisms, transient acoustic waves were compared to ablation thresholds and the volume of material removed. The ablation profile and depth were measured using optical coherence tomography (OCT). Irregular surface modification, charring and peripheral cracks were associated with dry ablation, whereas craters for spray samples were relatively clean without thermal damage. In spite of a 60% higher ablation threshold for spray associated irradiations owing to water absorption, acoustic peak pressures were six times higher and ablation volume was up to a factor of 2 larger compared to dry ablation. The enhanced pressure and ablation performance of the spray-assisted process was the result of rapid water vaporization, material ejection with recoil stress, interstitial water explosion and possibly liquid-jet formation. With water cooling and abrasive/disruptive mechanical effects, the spray ablation can be a safe and efficient modality for dental treatment.

  18. Effects of Laser Energy Density on Size and Morphology of NiO Nanoparticles Prepared by Pulsed Laser Ablation in Liquid

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Rory; Reddy, M. Amaranatha; Kim, Tae Kyu [Pusan National University, Busan (Korea, Republic of)

    2015-01-15

    Metaloxide nanoparticles are of great importance to a large variety of chemical and material applications ranging from catalysts to electronic devices. Among the metal-oxide nanoparticles, NiO is one of the technologically versatile and important semiconducting materials. It has been extensively investigated because of its myriad applications in catalysts, gas sensors, Li-ion battery materials, electrochromic coatings, active optical fibers, fuel cell electrodes, and so on. The effect of laser ablation at various laser energy densities was investigated. At low energy densities, the produced nanoparticles were of irregular morphology with an average size of 2.4 nm. At higher laser energy densities, the produced nanoparticles were spherical, with a polycrystalline structure and their average size was around 10 nm. More detailed investigations on effects of laser wavelength and energy density as well as the particle size effect on the catalytic activity of synthesized NiO nanoparticles will be investigated in future works.

  19. Percutaneous Microwave Ablation of Renal Angiomyolipomas

    Energy Technology Data Exchange (ETDEWEB)

    Cristescu, Mircea, E-mail: mcristescu@uwhealth.org [University of Wisconsin, Department of Radiology (United States); Abel, E. Jason, E-mail: abel@urology.wisc.edu [University of Wisconsin, Department of Urology (United States); Wells, Shane, E-mail: swells@uwhealth.org; Ziemlewicz, Timothy J., E-mail: tziemlewicz@uwhealth.org [University of Wisconsin, Department of Radiology (United States); Hedican, Sean P., E-mail: hedican@surgery.wisc.edu [University of Wisconsin, Department of Urology (United States); Lubner, Megan G., E-mail: mlubner@uwhealth.org; Hinshaw, J. Louis, E-mail: jhinshaw@uwhealth.org; Brace, Christopher L., E-mail: cbrace@uwhealth.org; Lee, Fred T., E-mail: flee@uwhealth.org [University of Wisconsin, Department of Radiology (United States)

    2016-03-15

    PurposeTo evaluate the safety and efficacy of US-guided percutaneous microwave (MW) ablation in the treatment of renal angiomyolipoma (AML).Materials and MethodsFrom January 2011 to April 2014, seven patients (5 females and 2 males; mean age 51.4) with 11 renal AMLs (9 sporadic type and 2 tuberous sclerosis associated) with a mean size of 3.4 ± 0.7 cm (range 2.4–4.9 cm) were treated with high-powered, gas-cooled percutaneous MW ablation under US guidance. Tumoral diameter, volume, and CT/MR enhancement were measured on pre-treatment, immediate post-ablation, and delayed post-ablation imaging. Clinical symptoms and creatinine were assessed on follow-up visits.ResultsAll ablations were technically successful and no major complications were encountered. Mean ablation parameters were ablation power of 65 W (range 60–70 W), using 456 mL of hydrodissection fluid per patient, over 4.7 min (range 3–8 min). Immediate post-ablation imaging demonstrated mean tumor diameter and volume decreases of 1.8 % (3.4–3.3 cm) and 1.7 % (27.5–26.3 cm{sup 3}), respectively. Delayed imaging follow-up obtained at a mean interval of 23.1 months (median 17.6; range 9–47) demonstrated mean tumor diameter and volume decreases of 29 % (3.4–2.4 cm) and 47 % (27.5–12.1 cm{sup 3}), respectively. Tumoral enhancement decreased on immediate post-procedure and delayed imaging by CT/MR parameters, indicating decreased tumor vascularity. No patients required additional intervention and no patients experienced spontaneous bleeding post-ablation.ConclusionOur early experience with high-powered, gas-cooled percutaneous MW ablation demonstrates it to be a safe and effective modality to devascularize and decrease the size of renal AMLs.

  20. Kinetic depletion model for pellet ablation

    Energy Technology Data Exchange (ETDEWEB)

    Kuteev, Boris V. [State Technical Univ., St. Petersburg (Russian Federation)

    2001-11-01

    A kinetic model for depletion effect, which determines pellet ablation when the pellet passes a rational magnetic surface, is formulated. The model predicts a moderate decrease of the ablation rate compared with the earlier considered monoenergy versions [1, 2]. For typical T-10 conditions the ablation rate reduces by a reactor of 2.5 when the 1-mm pellet penetrates through the plasma center. A substantial deceleration of pellets -about 15% per centimeter of low shire rational q region; is predicted. Penetration for Low Field Side and High Field Side injections is considered taking into account modification of the electron distribution function by toroidal magnetic field. It is shown that Shafranov shift and toroidal effects yield the penetration length for HFS injection higher by a factor of 1.5. This fact should be taken into account when plasma-shielding effects on penetration are considered. (author)

  1. Temperature sensitive liposomes combined with thermal ablation: Effects of duration and timing of heating in mathematical models and in vivo.

    Science.gov (United States)

    Rossmann, Christian; McCrackin, M A; Armeson, Kent E; Haemmerich, Dieter

    2017-01-01

    Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug at hyperthermic temperatures, typically above ~40°C. TSL have been combined with various heating modalities, but there is no consensus on required hyperthermia duration or ideal timing of heating relative to TSL administration. The goal of this study was to determine changes in drug uptake when heating duration and timing are varied when combining TSL with radiofrequency ablation (RF) heating. We used computer models to simulate both RF tissue heating and TSL drug delivery, to calculate spatial drug concentration maps. We simulated heating for 5, 12 and 30 min for a single RF electrode, as well as three sequential 12 min ablations for 3 electrodes placed in a triangular array. To support simulation results, we performed porcine in vivo studies in normal liver, where TSL filled with doxorubicin (TSL-Dox) at a dose of 30 mg was infused over 30 min. Following infusion, RF heating was performed in separate liver locations for either 5 min (n = 2) or 12 min (n = 2). After ablation, the animal was euthanized, and liver extracted and frozen. Liver samples were cut orthogonal to the electrode axis, and fluorescence imaging was used to visualize tissue doxorubicin distribution. Both in vivo studies and computer models demonstrate a ring-shaped drug deposition within ~1 cm of the visibly coagulated tissue. Drug uptake directly correlated with heating duration. In computer simulations, drug concentration increased by a factor of 2.2x and 4.3x when heating duration was extended from 5 to either 12, or 30 minutes, respectively. In vivo, drug concentration was by a factor of 2.4x higher at 12 vs 5 min heating duration (7.1 μg/g to 3.0 μg/g). The computer models suggest that heating should be timed to maximize area under the curve of systemic plasma concentration of encapsulated drug. Both computer models and in vivo study demonstrate that tissue drug uptake directly correlates with

  2. Power Laser Ablation Symposia

    CERN Document Server

    Phipps, Claude

    2007-01-01

    Laser ablation describes the interaction of intense optical fields with matter, in which atoms are selectively driven off by thermal or nonthermal mechanisms. The field of laser ablation physics is advancing so rapidly that its principal results are seen only in specialized journals and conferences. This is the first book that combines the most recent results in this rapidly advancing field with authoritative treatment of laser ablation and its applications, including the physics of high-power laser-matter interaction. Many practical applications exist, ranging from inertial confinement fusion to propulsion of aerostats for pollution monitoring to laser ignition of hypersonic engines to laser cleaning nanoscale contaminants in high-volume computer hard drive manufacture to direct observation of the electronic or dissociative states in atoms and molecules, to studying the properties of materials during 200kbar shocks developed in 200fs. Selecting topics which are representative of such a broad field is difficu...

  3. Pharmacological therapy following catheter ablation of atrial fibrillation.

    Science.gov (United States)

    Rordorf, Roberto; Savastano, Simone; Gandolfi, Edoardo; Vicentini, Alessandro; Petracci, Barbara; Landolina, Maurizio

    2012-01-01

    Catheter ablation has been proven to be an effective treatment for patients with drug-resistant atrial fibrillation. Nevertheless its efficacy is limited to 60-80% of patients in different studies. Whether the use of pharmacological therapy after catheter ablation of atrial fibrillation might increase the procedural success rate is still a matter of debate. There is general agreement that antiarrhythmic drugs (AADs) are useful in the management of arrhythmias occurring in the very early period after catheter ablation (blanking period). On the contrary, limited data are available on the efficacy of AADs over a longer period. Some patients remain free of arrhythmia recurrences by the use of AADs that were ineffective before catheter ablation: whether this latter situation is to be considered a partial success of catheter ablation or a treatment failure, thus demanding a redo procedure, is still an open question. Some studies have also investigated the role of non-AADs [angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, statins and corticosteroids] in preventing atrial fibrillation recurrences after catheter ablation, reporting conflicting results. Whereas there is a general consensus on the use of anticoagulation therapy in the first phase after catheter ablation, no definite data are available on the proper long-term management of anticoagulation therapy after catheter ablation. This review focuses on the still open issue of what is the optimal pharmacological treatment of patients after catheter ablation of atrial fibrillation.

  4. Matrix and energy effects during in-situ determination of Cu isotope ratios by ultraviolet-femtosecond laser ablation multicollector inductively coupled plasma mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lazarov, Marina, E-mail: m.lazarov@mineralogie.uni-hannover.de; Horn, Ingo

    2015-09-01

    to measure Cu isotopic ratios in native copper and Cu-bearing sulfides, carbonates and oxides in situ with a precision of better than 0.1‰ (2SD) without using a matrix-matched standard during laser ablation analyses. Thus, this is a suitable tool to resolve Cu isotopic zoning larger than 0.1‰ in Cu-sulfides, carbonates and oxides. - Highlights: • In-situ Cu isotope analyses of Cu alloys and various minerals with 0.1‰ precision • Non-matrix-matched calibration for Cu isotope ratio determinations • Energy density effect on the heat affected zone for in-situ Cu isotope analyses.

  5. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity.

    Science.gov (United States)

    Van't Veer, Ashlee; Bechtholt, Anita J; Onvani, Sara; Potter, David; Wang, Yujun; Liu-Chen, Lee-Yuan; Schütz, Günther; Chartoff, Elena H; Rudolph, Uwe; Cohen, Bruce M; Carlezon, William A

    2013-07-01

    Brain kappa-opioid receptors (KORs) are implicated in states of motivation and emotion. Activation of KORs negatively regulates mesolimbic dopamine (DA) neurons, and KOR agonists produce depressive-like behavioral effects. To further evaluate how KOR function affects behavior, we developed mutant mice in which exon 3 of the KOR gene (Oprk1) was flanked with Cre-lox recombination (loxP) sites. By breeding these mice with lines that express Cre-recombinase (Cre) in early embryogenesis (EIIa-Cre) or only in DA neurons (dopamine transporter (DAT)-Cre), we developed constitutive KOR knockouts (KOR(-/-)) and conditional knockouts that lack KORs in DA-containing neurons (DAT-KOR(lox/lox)). Autoradiography demonstrated complete ablation of KOR binding in the KOR(-/-) mutants, and reduced binding in the DAT-KOR(lox/lox) mutants. Quantitative reverse transcription PCR (qPCR) studies confirmed that KOR mRNA is undetectable in the constitutive mutants and reduced in the midbrain DA systems of the conditional mutants. Behavioral characterization demonstrated that these mutant lines do not differ from controls in metrics, including hearing, vision, weight, and locomotor activity. Whereas KOR(-/-) mice appeared normal in the open field and light/dark box tests, DAT-KOR(lox/lox) mice showed reduced anxiety-like behavior, an effect that is broadly consistent with previously reported effects of KOR antagonists. Sensitization to the locomotor-stimulating effects of cocaine appeared normal in KOR(-/-) mutants, but was exaggerated in DAT-KOR(lox/lox) mutants. Increased sensitivity to cocaine in the DAT-KOR(lox/lox) mutants is consistent with a role for KORs in negative regulation of DA function, whereas the lack of differences in the KOR(-/-) mutants suggests compensatory adaptations after constitutive receptor ablation. These mouse lines may be useful in future studies of KOR function.

  6. Effects of Radiofrequency Ablation on Lymphocyte Subsets and Type 1/Type 2 T Cell Subpopulations in Patients with Hepatocellular Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Yan-bin Wang; Wei-Guo Xu; He-liang Liu; Kun Yan; Lin Ma; Wan-hou Guo

    2009-01-01

    Objective: To evaluate whether radiofrequency ablation (RFA) might have an influence on immune status in hepatocellular carcinoma (HCC) patients. Methods: We measured the T lymphocytes, B lymphocyte and NK cells, and determined the population of Th1, Th2, Tc1 and Tc2 of peripheral blood samples taken from 26 HCC patients before and after RFA. Results: The proportion of Type1 cells (Th1 and Tc1) and NK cells were significantly increased after RFA, especially in patients of the following subgroups: male, age>55 years, pathological grade I-II tumor, clinical stage I-II or Child-Pugh A and B. Conclusion: Type1 cells and NK cells in HCC patients were increased in a short period after RFA.

  7. Radioiodine remnant ablation of differentiated thyroid cancer does not further increase oxidative damage to membrane lipids - early effect

    Directory of Open Access Journals (Sweden)

    Makarewicz Jacek

    2010-10-01

    Full Text Available Abstract Introduction Radioiodine (131I therapy is widely accepted as an essential part of therapeutic regimens in many cases of differentiated thyroid cancer. Radiation-induced oxidative damage to macromolecules is a well known phenomenon. Frequently examined process to evaluate oxidative damage to macromolecules is lipid peroxidation (LPO, resulting from oxidative damage to membrane lipids. The aim of the study was to examine serum LPO level in hypothyroid (after total thyroidectomy cancer patients subjected to ablative activities of 131I. Materials and methods The study was carried out in 21 patients (18 females and 3 males, average age 52.4 ± 16.5 years after total thyroidectomy for papillary (17 patients or follicular (4 patients thyroid carcinoma. Hypothyroidism was confirmed by increased TSH blood concentration (BRAHMS, Germany, measured before 131I therapy. Activity of 2.8 - 6.9 GBq of 131I was administered to the patients orally as sodium iodide (OBRI, Poland. Concentrations of malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA, as an index of LPO (LPO-586 kit, Calbiochem, USA, were measured in blood serum just before 131I administration (day "0" and on the days 1-4 after 131I therapy. Sera from 23 euthyroid patients served as controls. Correlations between LPO and TSH or 131I activity were calculated. Results Expectedly, serum LPO level, when measured before 131I therapy, was several times higher (p 131I therapy. LPO did not correlate with TSH concentration. In turn, negative correlation was found between 131I activity and LPO level on the day "2" after radioiodine treatment. Conclusions Radioiodine remnant ablation of differentiated thyroid cancer does not further increase oxidative damage to membrane lipids, at least early, after therapy.

  8. 心房颤动射频消融疗效评估的meta分析%Meta analysis of effect evaluation of radiofrequency ablation for atrial fibrillation

    Institute of Scientific and Technical Information of China (English)

    李衡西; 钟国强

    2016-01-01

    ABSTRACT:Objective to carry on Meta analysis of clinical effect of radiofrequency ablation in treatment of atrial fibrillation, and to explore its safety and recurrence.Methods retrieve clinical research data (December 2005 to December 2015) of EMBASE, MEDLINE, HighWire, CCRT electronic databases, and research data included clinical research and test of catheter ablation treating atrial fibrillation, screen and extract data according to criteria, and carry on Meta analysis with random effect model. Carry on sensitivity analysis for literature research characteristics and quality results.Results the study included a total of 8 clinical studies, 428 patients. Analysis and statistics showed, research had significant heterogeneity (I2= 0%,P>0.05); follow-up results showed, radiofrequency ablation and cryoablation had similar effect for sinus rhythm maintenance. treatment safety analysis showed, 4 cases treated by radiofrequency ablation had complications of pericardial effusion, and 7 cases by cryoablation had complications of phrenic nerve paralysis. Comparison of operative and fluoroscopy time between radiofrequency ablation and cryoablation showed no significant difference (P> 0.05). Left atrial volume and diameter of radiofrequency ablation patients was significantly lower than before operation.Conclusion radiofrequency ablation has same safety and similar effect compared with cryoablation, and the treatment method does not affect function of left atrial.%目的:针对射频导管消融术在心房颤动治疗中的临床疗效进行Meta分析,探讨射频消融在房颤治疗中的安全性以及复发情况。方法通过对EMBASE、MEDLINE、Highwire、CCRT电子数据库对临床研究资料(2005年12月至2015年12月)进行检索,研究资料为消融导管消融治疗心房颤动患者的临床研究及试验,根据筛查标准对文献进行筛查,提取资料,选用随机效应模型进行数据的Meta分析。对文献的研究特点以

  9. Ablation techniques for primary and metastatic liver tumors

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Ablative treatment methods have emerged as safe and effective therapies for patients with primary andsecondary liver tumors who are not surgical candidatesat the time of diagnosis. This article reviews the currentliterature and describes the techniques, complicationsand results for radiofrequency ablation, microwaveablation, cryoablation, and irreversible electroporation.

  10. Low vulnerability of the right phrenic nerve to electroporation ablation

    NARCIS (Netherlands)

    van Driel, Vincent J. H. M.; Neven, KGEJ; van Wessel, Harri; Vink, Aryan; Doevendans, Pieter A. F. M.; Wittkampf, Fred H. M.

    2015-01-01

    BACKGROUND Circular electroporation ablation is a novel ablation modality for electrical pulmonary vein isolation. With a single 200-3 application, deep circular myocardial lesions can be created. However, the acute and chronic effects of this energy source on phrenic nerve (PN) function are unknown

  11. Investigations on laser hard tissue ablation under various environments

    Energy Technology Data Exchange (ETDEWEB)

    Kang, H W [American Medical Systems-ICSV, San Jose, CA (United States); Oh, J [Division of Mechanical Engineering, Pukyong National University, Busan (Korea, Republic of); Welch, A J [Department of Biomedical Engineering, University of Texas at Austin, Austin, TX (United States)], E-mail: wook.kang@ammd.com

    2008-06-21

    The purpose of this study was to investigate the effect of liquid environments upon laser bone ablation. A long-pulsed Er,Cr:YSGG laser was employed to ablate bovine bone tibia at various radiant exposures under dry, wet (using water or perfluorocarbon) and spray environmental conditions. Energy loss by the application of liquid during laser irradiation was evaluated, and ablation performance for all conditions was quantitatively measured by optical coherence tomography (OCT). Microscope images were also used to estimate thermal side effects in tissue after multiple-pulse ablation. Wet using water and spray conditions equally attenuated the 2.79 {mu}m wavelength laser beam. Higher transmission efficiency was obtained utilizing a layer of perfluorocarbon. Dry ablation exhibited severe carbonization due to excessive heat accumulation. Wet condition using water resulted in similar ablation volume to the dry case without carbonization. The perfluorocarbon layer produced the largest ablation volume but some carbonization due to the poor thermal conductivity. Spray induced clean cutting with slightly reduced efficiency. Liquid-assisted ablation provided significant beneficial effects such as augmented material removal and cooling/cleaning effects during laser osteotomy.

  12. Low vulnerability of the right phrenic nerve to electroporation ablation

    NARCIS (Netherlands)

    van Driel, Vincent J. H. M.; Neven, KGEJ; van Wessel, Harri; Vink, Aryan; Doevendans, Pieter A. F. M.|info:eu-repo/dai/nl/164248366; Wittkampf, Fred H. M.|info:eu-repo/dai/nl/080434436

    BACKGROUND Circular electroporation ablation is a novel ablation modality for electrical pulmonary vein isolation. With a single 200-3 application, deep circular myocardial lesions can be created. However, the acute and chronic effects of this energy source on phrenic nerve (PN) function are

  13. Micrometeorological processes driving snow ablation in an Alpine catchment

    Directory of Open Access Journals (Sweden)

    R. Mott

    2011-08-01

    Full Text Available Mountain snow covers typically become patchy over the course of a melting season. The snow pattern during melt is mainly governed by the end of winter snow depth distribution and the local energy balance. The objective of this study is to investigate micrometeorological processes driving snow ablation in an Alpine catchment. For this purpose we combine a meteorological model (ARPS with a fully distributed energy balance model (Alpine3D. Turbulent fluxes above melting snow are further investigated by using data from eddy-correlation systems. We compare modelled snow ablation to measured ablation rates as obtained from a series of Terrestrial Laser Scanning campaigns covering a complete ablation season. The measured ablation rates indicate that the advection of sensible heat causes locally increased ablation rates at the upwind edges of the snow patches. The effect, however, appears to be active over rather short distances except for very strong wind conditions. Neglecting this effect, the model is able to capture the mean ablation rates for early ablation periods but strongly overestimates snow ablation once the fraction of snow coverage is below a critical value. While radiation dominates snow ablation early in the season, the turbulent flux contribution becomes important late in the season. Simulation results indicate that the air temperatures appear to overestimate the local air temperature above snow patches once the snow coverage is below a critical value. Measured turbulent fluxes support these findings by suggesting a stable internal boundary layer close to the snow surface causing a strong decrease of the sensible heat flux towards the snow cover. Thus, the existence of a stable internal boundary layer above a patchy snow cover exerts a dominant control on the timing and magnitude of snow ablation for patchy snow covers.

  14. Damage to Preheated Tungsten Targets after Multiple Plasma Impacts Simulating ITER ELMs

    Energy Technology Data Exchange (ETDEWEB)

    Garkusha, I.E.; Bandura, A.N.; Byrka, O.V.; Chebotarev, V.V.; Makhlay, V.A.; Tereshin, V.I. [Kharkov Inst. of Physics and Technology, Inst. of Plasma Physics of National Science Center, Akademicheskaya street, 1, 61108 Kharkov (Ukraine); Landman, I.; Pestchanyi, S. [FZK-Forschungszentrum Karlsruhe, Association Euratom-FZK, Technik und Umwelt, Postfach 3640, D-7602 1 Karlsruhe (Germany)

    2007-07-01

    Full text of publication follows: The energy loads onto ITER divertor surfaces associated with the Type I ELMs are expected to be up to 1 MJ/m{sup 2} during 0.1-0.5 ms, with the number of pulses about 103 per discharge. Tungsten is a candidate material for major part of the surface, but its brittleness can result in substantial macroscopic erosion after the repetitive heat loads. To minimize the brittle destruction, tungsten may be preheated above the ductile-to-brittle transition temperature. In this work the behavior of preheated tungsten targets under repetitive ELM-like plasma pulses is studied in simulation experiments with the quasi-stationary plasma accelerator QSPA Kh-50. The targets have been exposed up to 450 pulses of the duration 0.25 ms and the heat loads either 0.45 MJ/m{sup 2} or 0.75 MJ/m{sup 2}, which is respectively below and above the melting threshold. During the exposures the targets were permanently kept preheated at 650 deg. C by a heater at target backside. In the course of exposures the irradiated surfaces were examined after regular numbers of pulses using the SEM and the optical microscopy. The profilometry, XRD, microhardness and weight loss measurements have been performed, as well as comparisons of surface damages after the heat loads both below and above the melting threshold. It is obtained that macro-cracks do not develop on the preheated surface. After the impacts with surface melting, a fine mesh of intergranular microcracks has appeared. The width of fine intergranular cracks grows with pulse number, achieving 1-1.5 microns after 100 pulses, and after 210 pulses the crack width increases up to 20 microns, which is comparable with grain sizes. Threshold changes in surface morphology resulting in corrugation structures and pits on the surface as well as importance of surface tension in resulted 'micro-brush' structures are discussed. Further evolution of the surface pattern is caused by loss of separated grains on exposed

  15. Experimental data and boundary conditions for a Double - Skin Facade building in preheating mode

    DEFF Research Database (Denmark)

    Larsen, Olena Kalyanova; Heiselberg, Per; Jensen, Rasmus Lund

    was carried out in a full scale test facility ‘The Cube’, in order to compile three sets of high quality experimental data for validation purposes. The data sets are available for preheating mode, external air curtain mode and transparent insulation mode. The objective of this article is to provide the reader......’. This covers such problem areas as measurements of naturally induced air flow, measurements of air temperature under direct solar radiation exposure, etc. Finally, in order to create a solid foundation for software validation, the uncertainty and limitations in the experimental results are discussed. In part...

  16. Optimal Heater Control with Technology of Fault Tolerance for Compensating Thermoforming Preheating System

    Directory of Open Access Journals (Sweden)

    Zhen-Zhe Li

    2015-01-01

    Full Text Available The adjustment of heater power is very important because the distribution of thickness strongly depends on the distribution of sheet temperature. In this paper, the steady state optimum distribution of heater power is searched by numerical optimization in order to get uniform sheet temperature. In the following step, optimal heater power distribution with a damaged heater was found out using the technology of fault tolerance, which will be used to reduce the repairing time when some heaters are damaged. The merit of this work is that the design variable was the power of each heater which can be directly used in the preheating process of thermoforming.

  17. Tumor ablations in IMRI

    Institute of Scientific and Technical Information of China (English)

    Roberto Blanco Sequeiros

    2002-01-01

    @@ IntroductionMagnetic resonance imaging based guidance control and monitoring of minimally invasive intervention has developed from a hypothetical concept to a practical possibility. Magnetic-resonance-guided interstitial therapy in principle is defined as a treatment technique for ablating deepseated tumors in the human body.

  18. Chemical and Spectroscopic Aspects of Polymer Ablation-Special Features and Novel Directions-

    Science.gov (United States)

    Lippert, Thomas

    2004-03-01

    Laser ablation of polymers has become an established technique in the electronic industry and the large number of studies published annually indicates that this is still an attractive area of research. Several new approaches with new techniques and materials have given new insights in the ablation process. One of these approaches is the development of polymers designed specifically for laser ablation which are a unique tool for probing the ablation mechanisms as well as for improving ablation properties. These novel polymers exhibit very low thresholds of ablation, with high ablation rates (even at low fluences), and excellent ablation quality. New commercial applications will require improved ablation rates and control of undesirable surface effects, such as debris. The complexity of the interactions between polymers and laser photons are illustrated by the various processes associated with different irradiation conditions. i) Photothermal-photochemical laser ablation under excimer laser irradiation. ii) Dopant-induced laser ablation. iii) Photo-oxidative etching with lamps in an oxidizing atmosphere. iv) VUV etching in the absence of oxidizing conditions. v) Photokinetic etching with CW UV lasers. vi) Ultrafast laser ablation, affected by pulse length, wavelength, and possibly shock waves. vii) Shock assisted photothermal ablation on picosecond time scales. viii) VUV laser ablation: purely photochemical? ix) Synchrotron structuring. x) Mid-IR ablation (FEL and CO2 laser), the influence of exciting various functional groups. Several of these new approaches and processes will be discussed to emphasize the importance of different approaches but also to review some fundamental processes. The combination of various experimental techniques (new approaches and 'well-known') with materials made to measure has given new insights in the ablation mechanisms, but has also shown new possible future directions of laser polymer ablation.

  19. Computer modeling of the combined effects of perfusion, electrical conductivity, and thermal conductivity on tissue heating patterns in radiofrequency tumor ablation.

    Science.gov (United States)

    Ahmed, Muneeb; Liu, Zhengjun; Humphries, Stanley; Goldberg, S Nahum

    2008-11-01

    To use an established computer simulation model of radiofrequency (RF) ablation to characterize the combined effects of varying perfusion, and electrical and thermal conductivity on RF heating. Two-compartment computer simulation of RF heating using 2-D and 3-D finite element analysis (ETherm) was performed in three phases (n = 88 matrices, 144 data points each). In each phase, RF application was systematically modeled on a clinically relevant template of application parameters (i.e., varying tumor and surrounding tissue perfusion: 0-5 kg/m(3)-s) for internally cooled 3 cm single and 2.5 cm cluster electrodes for tumor diameters ranging from 2-5 cm, and RF application times (6-20 min). In the first phase, outer thermal conductivity was changed to reflect three common clinical scenarios: soft tissue, fat, and ascites (0.5, 0.23, and 0.7 W/m- degrees C, respectively). In the second phase, electrical conductivity was changed to reflect different tumor electrical conductivities (0.5 and 4.0 S/m, representing soft tissue and adjuvant saline injection, respectively) and background electrical conductivity representing soft tissue, lung, and kidney (0.5, 0.1, and 3.3 S/m, respectively). In the third phase, the best and worst combinations of electrical and thermal conductivity characteristics were modeled in combination. Tissue heating patterns and the time required to heat the entire tumor +/-a 5 mm margin to >50 degrees C were assessed. Increasing background tissue thermal conductivity increases the time required to achieve a 50 degrees C isotherm for all tumor sizes and electrode types, but enabled ablation of a given tumor size at higher tissue perfusions. An inner thermal conductivity equivalent to soft tissue (0.5 W/m- degrees C) surrounded by fat (0.23 W/m- degrees C) permitted the greatest degree of tumor heating in the shortest time, while soft tissue surrounded by ascites (0.7 W/m- degrees C) took longer to achieve the 50 degrees C isotherm, and complete ablation

  20. Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models.

    Science.gov (United States)

    Schmitt, Laurenz; Amann, P M; Marquardt, Y; Heise, R; Czaja, K; Gerber, P A; Steiner, T; Hölzle, F; Baron, Jens Malte

    2017-05-01

    The molecular changes in gene expression following ablative laser treatment of skin lesions, such as atrophic scars and UV-damaged skin, are not completely understood. A standardized in vitro model of human skin, to study the effects of laser treatment on human skin, has been recently developed. Therefore, the aim of the investigation was to examine morphological and molecular changes caused by fractional ablative erbium:YAG laser treatment on an in vitro full-thickness 3D standardized organotypic model of human skin. A fractional ablative erbium:YAG laser was used to irradiate organotypic human 3D models. Laser treatments were performed at four different settings using a variety of stacked pulses with similar cumulative total energy fluence (60 J/cm(2)). Specimens were harvested at specified time points and real-time PCR (qRT-PCR) and microarray studies were performed. Frozen sections were examined histologically. Three days after erbium:YAG laser treatment, a significantly increased mRNA expression of matrix metalloproteinases and their inhibitors (MMP1, MMP2, MMP3, TIMP1, and TIMP2), chemokines (CXCL1, CXCL2, CXCL5, and CXCL6), and cytokines such as IL6, IL8, and IL24 could be detected. qRT-PCR studies confirmed the enhanced mRNA expression of IL6, IL8, IL24, CXCLs, and MMPs. In contrast, the mRNA expression of epidermal differentiation markers, such as keratin-associated protein 4, filaggrin, filaggrin 2, and loricrin, and antimicrobial peptides (S100A7A, S100A9, and S100A12) as well as CASP14, DSG2, IL18, and IL36β was reduced. Four different settings with similar cumulative doses have been tested (N10%, C10%, E10%, and W25%). These laser treatments resulted in different morphological changes and effects on gene regulations. Longer pulse durations (1000 μs) especially had the strongest impact on gene expression and resulted in an upregulation of genes, such as collagen-1A2, collagen-5A2, and collagen-6A2, as well as FGF2. Histologically, all treatment

  1. Ultrasound-guided percutaneous thermal ablation of hepatocellular carcinoma using microwave and radiofrequency ablation

    Energy Technology Data Exchange (ETDEWEB)

    Xu, H.-X.; Xie, X.-Y.; Lu, M.-D. E-mail: lumd@21cn.com; Chen, J.-W.; Yin, X.-Y.; Xu, Z.-F.; Liu, G.-J

    2004-01-01

    AIM: To investigate the therapeutic efficacy of thermal ablation for treatment of hepatocellular carcinoma (HCC) using microwave and radiofrequency (RF) energy application. MATERIALS AND METHODS: A total of 190 nodules in 97 patients (84 male, 13 female; mean age 53.4 years, range 24-74 years) with HCC were treated with microwave or RF ablation in the last 4 years. The applicators were introduced into the tumours under conscious analgesic sedation by intravenous administration of fentanyl citrate and droperidol and local anaesthesia in both thermal ablation procedures. The patients were then followed up with contrast-enhanced computed tomography (CT) to evaluate treatment response. Survival was analysed using the Kaplan-Meier method. RESULTS: Complete ablation was obtained in 92.6% (176/190) nodules. The complete ablation rates were 94.6% (106/112) in microwave ablation and 89.7% (70/78) in RF ablation. The complete ablation rates in tumours{<=}2.0, 2.1-3.9 and {>=}4.0 cm were 93.1, 93.8 and 86.4%, respectively. Local recurrence was found in 9.5% nodules and the rates in tumours{<=}2.0, 2.1-3.9 and {>=}4.0 cm in diameter were 3.4, 9.9 and 31.8%, respectively. In the follow-up period, 7.1% nodules ablated by microwave and 12.8% by RF presented local recurrence. The 1, 2 and 3-year distant recurrence-free survivals were 47.2, 34.9 and 31.0%, respectively. Estimated mean survival was 32 months, and 1, 2 and 3-year cumulative survivals were 75.6, 58.5, and 50.0%, respectively. One and 2 years survivals of Child-Pugh class A, B and C patients were 83.8 and 70.4%, 78.2 and 53.2%, 36.3 and 27.3%, respectively. CONCLUSION: Thermal ablation therapy by means of microwave and RF energy application is an effective and safe therapeutic technique for hepatocellular carcinoma. Large tumours can be completely ablated, but have a significantly higher risk of local recurrence at follow-up.

  2. Pulsed Tm:YAG laser ablation of knee joint tissues

    Science.gov (United States)

    Shi, Wei-Qiang; Vari, Sandor G.; Duffy, J. T.; Miller, J. M.; Weiss, Andrew B.; Fishbein, Michael C.; Grundfest, Warren S.

    1992-06-01

    We investigated the effect of a free-running 2.01 micron pulsed Tm:YAG laser on bovine knee joint tissues. Ablation rates of fresh fibrocartilage, hyaline cartilage, and bone were measured in saline as a function of laser fluence (160 - 640 J/cm2) and fiber core size (400 and 600 microns). All tissues could be effectively ablated and the ablation rate increased linearly with the increasing fluence. Use of fibers of different core sizes, while maintaining constant energy fluence, did not result in significant difference in ablation rate. Histology analyses of the ablated tissue samples reveal average Tm:YAG radiation induced thermal damage (denatunalization) zones ranging between 130 and 540 microns, depending on the laser parameters and the tissue type.

  3. Little evidence for entropy and energy excess beyond r500 - an end to ICM pre-heating?

    Science.gov (United States)

    Iqbal, Asif; Majumdar, Subhabrata; Nath, Biman B.; Ettori, Stefano; Eckert, Dominique; Malik, Manzoor A.

    2017-02-01

    Non-gravitational feedback affects the nature of the intracluster medium (ICM). X-ray cooling of the ICM and in situ energy feedback from active galactic nuclei (AGNs) and supernovae as well as pre-heating of the gas at epochs preceding the formation of clusters are proposed mechanisms for such feedback. While cooling and AGN feedbacks are dominant in cluster cores, the signatures of a pre-heated ICM are expected to be present even at large radii. To estimate the degree of pre-heating, with minimum confusion from AGN feedback/cooling, we study the excess entropy and non-gravitational energy profiles up to r200 for a sample of 17 galaxy clusters using joint data sets of Planck Sunyaev-Zel'dovich pressure and ROSAT/Position Sensitive Proportional Counter gas density profiles. The canonical value of pre-heating entropy floor of ≳300 keV cm2, needed in order to match cluster scalings, is ruled out at ≈3σ. We also show that the feedback energy of 1 keV particle-1 is ruled out at 5.2σ beyond r500. Our analysis takes both non-thermal pressure and clumping into account which can be important in outer regions. Our results based on the direct probe of the ICM in the outermost regions do not support any significant pre-heating.

  4. Estimating Effective Dose from Phantom Dose Measurements in Atrial Fibrillation Ablation Procedures and Comparison of MOSFET and TLD Detectors in a Small Animal Dosimetry Setting

    Science.gov (United States)

    Anderson-Evans, Colin David

    Two different studies will be presented in this work. The first involves the calculation of effective dose from a phantom study which simulates an atrial fibrillation (AF) ablation procedure. The second involves the validation of metal-oxide semiconducting field effect transistors (MOSFET) for small animal dosimetry applications as well as improved characterization of the animal irradiators on Duke University's campus. Atrial Fibrillation is an ever increasing health risk in the United States. The most common type of cardiac arrhythmia, AF is associated with increased mortality and ischemic cerebrovascular events. Managing AF can include, among other treatments, an interventional procedure called catheter ablation. The procedure involves the use of biplane fluoroscopy during which a patient can be exposed to radiation for as much as two hours or more. The deleterious effects of radiation become a concern when dealing with long fluoroscopy times, and because the AF ablation procedure is elective, it makes relating the risks of radiation ever more essential. This study hopes to quantify the risk through the derivation of dose conversion coefficients (DCCs) from the dose-area product (DAP) with the intent that DCCs can be used to provide estimates of effective dose (ED) for typical AF ablation procedures. A bi-plane fluoroscopic and angiographic system was used for the simulated AF ablation procedures. For acquisition of organ dose measurements, 20 diagnostic MOSFET detectors were placed at selected organs in a male anthropomorphic phantom, and these detectors were attached to 4 bias supplies to obtain organ dose readings. The DAP was recorded from the system console and independently validated with an ionization chamber and radiochromic film. Bi-plane fluoroscopy was performed on the phantom for 10 minutes to acquire the dose rate for each organ, and the average clinical procedure time was multiplied by each organ dose rate to obtain individual organ doses. The

  5. Numerical Modeling of Ablation Heat Transfer

    Science.gov (United States)

    Ewing, Mark E.; Laker, Travis S.; Walker, David T.

    2013-01-01

    A unique numerical method has been developed for solving one-dimensional ablation heat transfer problems. This paper provides a comprehensive description of the method, along with detailed derivations of the governing equations. This methodology supports solutions for traditional ablation modeling including such effects as heat transfer, material decomposition, pyrolysis gas permeation and heat exchange, and thermochemical surface erosion. The numerical scheme utilizes a control-volume approach with a variable grid to account for surface movement. This method directly supports implementation of nontraditional models such as material swelling and mechanical erosion, extending capabilities for modeling complex ablation phenomena. Verifications of the numerical implementation are provided using analytical solutions, code comparisons, and the method of manufactured solutions. These verifications are used to demonstrate solution accuracy and proper error convergence rates. A simple demonstration of a mechanical erosion (spallation) model is also provided to illustrate the unique capabilities of the method.

  6. Laser Thermal Ablation of Thyroid Benign Nodules.

    Science.gov (United States)

    Shahrzad, Mohammad Karim

    2015-01-01

    Thermal ablation therapies for benign thyroid nodules have been introduced in recent years to avoid the complications of traditional methods such as surgery. Despite the little complications and the reportedly acceptable efficacy of thermal ablation methods, quite few medical centers have sought the potential benefits of employing them. This paper provides an introduction to the literature, principles and advances of Percutaneous Laser Ablation therapy of thyroid benign nodules, as well as a discussion on its efficacy, complications and future. Several clinical research papers evaluating the thermal effect of laser on the alleviation of thyroid nodules have been reviewed to illuminate the important points. The results of this research can help researchers to advance the approach and medical centers to decide on investing in these novel therapies.

  7. Radiofrequency ablation for treatment of atrial fibrillation.

    Science.gov (United States)

    Safaei, Nasser; Montazerghaem, Hossein; Azarfarin, Rasoul; Alizadehasl, Azin; Alikhah, Hossein

    2011-01-01

    Atrial Fibrillation (AF) is the most common cardiac arrhythmia which represents a major public health problem. The main purpose of this research is to evaluate the Radiofrequency (RF) ablation effects in the patients with chronic AF scheduled for cardiac surgery because of different heart diseases. The descriptive and prospective study was conducted on 60 patients with AF scheduled for surgery along with RF ablation. The data were collected by questionnaire and included: patients' age, sex, NYHA class, operation type, past medical history, type and cause of valvular heart disease, preoperative ECG (electrocardiogram), duration of surgery, clamping time, cardiopulmonary bypass, and RF ablation time. RF ablation was followed by the main operation. The follow up examination, ECG, and echocardiography were performed 3 and 6 months after operation. The mean age of patients was 48±10 years (18-71 years). Forty one patients had permanent AF and 19 had the persistent AF. The left ventricular ejection fraction was 48.27±9.75 percent before operation, and reached to 56.27±7.87 percent after the surgery (P<0.001). The mean NYHA class before the surgery was 2.83±0.68 which decreased to 1.34±0.46 6 months after the surgery with RF ablation (P<0.001). One patient (1.6%) died after surgery. Complete relief and freedom from AF recurrence was observed in 70% of patients in the mean follow up in 7 months after the surgery. The sinus rhythm with efficient atrial contraction was established in 100% of discharged patients. RF ablation is an effective procedure to cure atrial fibrillation in patients undergoing cardiac surgeries.

  8. Effect of Ablation Rate on the Microstructure and Electrochromic Properties of Pulsed-Laser-Deposited Molybdenum Oxide Thin Films.

    Science.gov (United States)

    Santhosh, S; Mathankumar, M; Selva Chandrasekaran, S; Nanda Kumar, A K; Murugan, P; Subramanian, B

    2017-01-10

    Molybdenum trioxide (MoO3) is a well-known electrochromic material. In the present work, n-type α-MoO3 thin films with both direct and indirect band gaps were fabricated by varying the laser repetition (ablation) rate in a pulsed laser deposition (PLD) system at a constant reactive O2 pressure. The electrochromic properties of the films are compared and correlated to the microstructure and molecular-level coordination. Mixed amorphous and textured crystallites evolve at the microstructural level. At the molecular level, using NMR and EPR, we show that the change in the repetition rate results in a variation of the molybdenum coordination with oxygen: at low repetition rates (2 Hz), the larger the octahedral coordination, and greater the texture, whereas at 10 Hz, tetrahedral coordination is significant. The anion vacancies also introduce a large density of defect states into the band gap, as evidenced by XPS studies of the valence band and supported by DFT calculations. The electrochromic contrast improved remarkably by almost 100% at higher repetition rates whereas the switching speed decreased by almost 6-fold. Although the electrochromic contrast and coloration efficiency were better at higher repetition rates, the switching speed, reversibility, and stability were better at low repetition rates. This difference in the electrochromic properties of the two MoO3 films is attributed to the variation in the defect and molecular coordination states of the Mo cation.

  9. High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects.

    Science.gov (United States)

    Van Acker, Thibaut; Van Malderen, Stijn J M; Van Heerden, Marjolein; McDuffie, James Eric; Cuyckens, Filip; Vanhaecke, Frank

    2016-11-16

    Two-dimensional elemental mapping (bioimaging) via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was performed on 5 μm thick formalin-fixed, paraffin-embedded kidney tissue sections from Cynomolgus monkeys administered with increasing pharmacological doses of cisplatin. Laterally resolved pixels of 1 μm were achieved, enabling elemental analysis on a (sub-)cellular level. Zones of high Pt response were observed in the renal cortex, where proximal tubules are present, the epithelium of which is responsible for partial reabsorption of cisplatin. Histopathological evaluation, of hematoxylin and eosin-stained serial sections, adjacent to the sections probed via LA-ICP-MS, revealed minimal to mild cisplatin-related lesions (<100 μm) in the renal cortex. Necrotic proximal tubules with sloughed epithelial cells in their lumen could be linked directly to the areas with the highest accumulation of cisplatin, indicating a direct link between cellular concentration and toxicity, thereby providing more insight into the mechanisms through which renal damage occurs.

  10. Numerical study for the effects of ablation and pyrolysis on the hypersonic reentry flow%碳-酚醛材料烧蚀热解对再入流场特性影响的数值计算

    Institute of Scientific and Technical Information of China (English)

    张威; 曾明; 肖凌飞; 徐丹

    2014-01-01

    Through numerically simulating the hypersonic reentry flow with ablation of carbon-phenolic heat-shield,the effects of ablation and pyrolysis on the thermochemical properties and electron densities of the flowfield were analyzed.19 chemical species were considered and a two-temperature model was taken to describe the thermal nonequilibrium.The Navier-Stokes equations of thermochemical nonequilibrium flow coupled with the ablating boundary condition were solved to obtain the steady-state solution of the flowfiled.The effects of ablation were shown in comparison with the non-ablating baseline case,which has a non-reacting,non-catalytic wall and equilibrium radiation wall temperature.The method to determine surface chemical composition of the pyrolysis gas was discussed,and the effects of the pyrolysis ratio were investigated.The simulation and analysis performed on RAM-C model at flight speed of7.65km/s and altitude of61km or71km show that,the dominant ablation and pyrolysis species are CO,H2 and H,and both the ablation species and the effects of ablation are limited to the boundary layer.The mass fractions of atoms and ions decline as a result of ablation and this may result in the decrease of the peak values of electron density when they appear in the boundary layer.Furthermore,the ablation effects become more pronounced as the pyrolysis ratio rises,and the effects extend further into the flowfield with increasing distance from the stagnation point or with higher flight altitude.%数值模拟存在碳-酚醛材料烧蚀的高超声速再入流场,分析烧蚀和热解对流场热化学参数、电子数密度分布等的影响。采用19组元双温度的热化学模型,耦合热化学非平衡流 Navier-Stokes方程组和烧蚀壁面边界条件,进行定常烧蚀流场求解;通过对比无烧蚀、非催化和辐射平衡壁温条件下的流场分析烧蚀的影响;讨论了壁面处碳-酚醛材料热解产物化学组成的确定方法,研究了

  11. Gasifier selection, design and gasification of oil palm fronds with preheated and unheated gasifying air.

    Science.gov (United States)

    Guangul, Fiseha M; Sulaiman, Shaharin A; Ramli, Anita

    2012-12-01

    Oil palm frond biomass is abundantly available in Malaysia, but underutilized. In this study, gasifiers were evaluated based on the available literature data and downdraft gasifiers were found to be the best option for the study of oil palm fronds gasification. A downdraft gasifier was constructed with a novel height adjustment mechanism for changing the position of gasifying air and steam inlet. The oil palm fronds gasification results showed that preheating the gasifying air improved the volumetric percentage of H(2) from 8.47% to 10.53%, CO from 22.87% to 24.94%, CH(4) from 2.02% to 2.03%, and higher heating value from 4.66 to 5.31 MJ/Nm(3) of the syngas. In general, the results of the current study demonstrated that oil palm fronds can be used as an alternative energy source in the energy diversification plan of Malaysia through gasification, along with, the resulting syngas quality can be improved by preheating the gasifying air.

  12. Velocity Interferometer blanking due to preheating in a double pulse planar experiment

    Energy Technology Data Exchange (ETDEWEB)

    Laffite, S.; Combis, P.; Clerouin, J.; Recoules, V.; Rousseaux, C.; Videau, L. [CEA, DAM, DIF, F-91297 Arpajon (France); Baton, S. D.; Koenig, M. [LULI, Ecole Polytechnique, CNRS, CEA, UPMC, route de Saclay, 91128 Palaiseau (France)

    2014-08-15

    Optical diagnostics, such as VISAR (Velocity Interferometer System for Any Reflector) or SOP (Streaked Optical Pyrometry), have become essential in shock timing experiments. Their high precision allows for accurate measurements of shock velocities, chronometry, and brightness temperature. However, in some instances, these measurements can be compromised. In planar shock coalescence experiments recently performed at the LULI facility [Baton et al., Phys. Rev. Lett. 108, 195002 (2012)], VISAR signal loss was observed. In these experiments, a strong shock launched by a high-intensity spike catches up with a previously shock launched by an earlier, low-intensity beam. The disappearance of the VISAR signal is attributed to a preheating of the coronal plasma by x-rays generated by the high intensity spike. The signal does not disappear if the high-intensity spike starts after VISAR probe beam begins to reflect off of the first shock. The VISAR diagnostic, modeled using an assessment of the optical index in quartz, compares favorably to experimental results. This provides evidence that x-ray preheating can cause blanking of the VISAR signal in quartz.

  13. Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study.

    Science.gov (United States)

    Yue, Wen-Wen; Li, Xiao-Long; Xu, Hui-Xiong; Lu, Feng; Sun, Li-Ping; Guo, Le-Hang; He, Ya-Ping; Wang, Dan; Yin, Zhi-Qiang

    2016-11-24

    This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT. Sensitivity analyses of costs of RFA were performed. At 6-month visit, patients treated with RFA had significantly better HRQoL than patients treated with OT on general health (68.5 versus 66.7, P = 0.029), vitality (71.3 versus 67.5, P RFA was more effective than OT in terms of quality-adjusted life-years (QALYs; 0.01QALY/patient) but more expensive (US$823/patient). The probability that RFA would be cost effective at a US$50,000/QALY threshold was 15.5% in China, and it would be increased to 88.4% when price of the RFA device was lowered by 30%. RFA exhibited a significant improvement of HRQoL relative to OT, but is unlikely to be cost effective at its current price in short time.

  14. Application of high strength sonic soot blower in air preheater of 1 000 MW units%高强声波吹灰器在1000 MW机组空预器中的应用

    Institute of Scientific and Technical Information of China (English)

    李彦民; 王俊杰

    2016-01-01

    There are some problems existed in the running of air preheater in CLP vote of Henan Electric Power co. LTD. ,Pingdingshan Power 2 x 1 000 MW ultra supercritical units. The air preheater had a large amount of dust ,so the resistance increased which is one of the important reasons affecting the safe and economic opera-tion. The sonic soot blower is applied in air preheater to prevent the dust and its effect is analyzed. The practi-cal application results show that the efficient acoustic wave sootblower are deposited in the air preheater and has obvious effect, the safety benefit, economic benefit and social benefit are remarkable.%介绍了中电投河南电力有限公司平顶山发电分公司2×1000 MW超超临界机组空预器在运行中出现的大量积灰情况,空预器阻力的大幅增加是影响机组安全、经济运行的重要原因。分析通过空预器加装声波吹灰器后对防止空预器大量积灰的效果,根据实践应用结果表明,高效声波吹灰器对空预器积灰有明显效果,安全效益、经济效益及社会效益显著。

  15. Radiofrequency Ablation for Treatment of Symptomatic Uterine Fibroids

    Directory of Open Access Journals (Sweden)

    Siân Jones

    2012-01-01

    Full Text Available The use of thermal energy-based systems to treat uterine fibroids has resulted in a plethora of devices that are less invasive and potentially as effective in reducing symptoms as traditional options such as myomectomy. Most thermal ablation devices involve hyperthermia (heating of tissue, which entails the conversion of an external electromagnetic or ultrasound waves into intracellular mechanical energy, generating heat. What has emerged from two decades of peer-reviewed research is the concept that hyperthermic fibroid ablation, regardless of the thermal energy source, can create large areas of necrosis within fibroids resulting in reductions in fibroid volume, associated symptoms and the need for reintervention. When a greater percentage of a fibroid's volume is ablated, symptomatic relief is more pronounced, quality of life increases, and it is more likely that such improvements will be durable. We review radiofrequency ablation (RFA, one modality of hyperthermic fibroid ablation.

  16. 提高蒸馏醪液预热温度的研究%Improvement of Distilled Mash Preheat Temperature

    Institute of Scientific and Technical Information of China (English)

    郭传广; 何松贵; 卫云路

    2016-01-01

    In order to improve the distillation efficiency, reduce energy consumption through the transformation of existing retort, increasing the heat transfer area of the heat exchanger, so be distilled mash temperature than the original improved 45.3%, 7.5 single retort distillation save time min, to achieve annual savings of 7.26%of steam. Further, the test vegetarian tasting that wine quality, to improve the preheating temperature of the mash vegetarian wine quality has little effect on stability vegetarian wine quality.%为了提高蒸馏效率,降低能耗,通过对现有蒸馏甑进行改造,增大了换热器的换热面积,使得待蒸馏的醪液温度较原来的提升了45.3%,单甑蒸馏节约时间7.5min,全年可实现节约蒸汽7.26%。另外,通过对试验斋酒质量的品评得知,提高醪液预热温度对斋酒质量影响不大,斋酒质量稳定。

  17. Ablation of high-Z material dust grains in edge plasmas of magnetic fusion devices

    Science.gov (United States)

    Marenkov, E. D.; Krasheninnikov, S. I.

    2014-12-01

    The model, including shielding effects of high-Z dust grain ablation in tokamak edge plasma, is presented. In a contrast to shielding models developed for pellets ablation in a hot plasma core, this model deals with the dust grain ablation in relatively cold edge plasma. Using some simplifications, a closed set of equations determining the grain ablation rate Γ is derived and analyzed both analytically and numerically. The scaling law for Γ versus grain radius and ambient plasma parameters is obtained and confirmed by the results of numerical solutions. The results obtained are compared with both dust grain models containing no shielding effects and the pellet ablation models.

  18. Diagnostics of laser ablated plasma plumes

    DEFF Research Database (Denmark)

    Amoruso, S.; Toftmann, B.; Schou, Jørgen;

    2004-01-01

    The effect of an ambient gas on the expansion dynamics of laser ablated plasmas has been studied for two systems by exploiting different diagnostic techniques. First, the dynamics of a MgB2 laser produced plasma plume in an Ar atmosphere has been investigated by space-and time-resolved optical...

  19. Modeling sublimation of a charring ablator

    Science.gov (United States)

    Balhoff, J. F.; Pike, R. W.

    1973-01-01

    The Hertz-Knudsen analysis is shown to accurately predict the sublimation rate from a charring ablator. Porosity is shown to have a significant effect on the surface temperature. The predominant carbon species found in the vapor is C3, which agrees well with the results of previous investigations.

  20. Ablative Rocket Deflector Testing and Computational Modeling

    Science.gov (United States)

    Allgood, Daniel C.; Lott, Jeffrey W.; Raines, Nickey

    2010-01-01

    A deflector risk mitigation program was recently conducted at the NASA Stennis Space Center. The primary objective was to develop a database that characterizes the behavior of industry-grade refractory materials subjected to rocket plume impingement conditions commonly experienced on static test stands. The program consisted of short and long duration engine tests where the supersonic exhaust flow from the engine impinged on an ablative panel. Quasi time-dependent erosion depths and patterns generated by the plume impingement were recorded for a variety of different ablative materials. The erosion behavior was found to be highly dependent on the material s composition and corresponding thermal properties. For example, in the case of the HP CAST 93Z ablative material, the erosion rate actually decreased under continued thermal heating conditions due to the formation of a low thermal conductivity "crystallization" layer. The "crystallization" layer produced near the surface of the material provided an effective insulation from the hot rocket exhaust plume. To gain further insight into the complex interaction of the plume with the ablative deflector, computational fluid dynamic modeling was performed in parallel to the ablative panel testing. The results from the current study demonstrated that locally high heating occurred due to shock reflections. These localized regions of shock-induced heat flux resulted in non-uniform erosion of the ablative panels. In turn, it was observed that the non-uniform erosion exacerbated the localized shock heating causing eventual plume separation and reversed flow for long duration tests under certain conditions. Overall, the flow simulations compared very well with the available experimental data obtained during this project.

  1. Tumor ablation with irreversible electroporation.

    Directory of Open Access Journals (Sweden)

    Bassim Al-Sakere

    Full Text Available We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the cell membrane. Mathematical models of the electrical and thermal fields that develop during the application of the pulses were used to design an efficient treatment protocol with minimal heating of the tissue. Tumor regression was confirmed by histological studies which also revealed that it occurred as a direct result of irreversible cell membrane permeabilization. Parametric studies show that the successful outcome of the procedure is related to the applied electric field strength, the total pulse duration as well as the temporal mode of delivery of the pulses. Our best results were obtained using plate electrodes to deliver across the tumor 80 pulses of 100 micros at 0.3 Hz with an electrical field magnitude of 2500 V/cm. These conditions induced complete regression in 12 out of 13 treated tumors, (92%, in the absence of tissue heating. Irreversible electroporation is thus a new effective modality for non-thermal tumor ablation.

  2. Coverage planning in computer-assisted ablation based on Genetic Algorithm.

    Science.gov (United States)

    Ren, Hongliang; Guo, Weian; Sam Ge, Shuzhi; Lim, Wancheng

    2014-06-01

    An ablation planning system plays a pivotal role in tumor ablation procedures, as it provides a dry run to guide the surgeons in a complicated anatomical environment. Over-ablation, over-perforation or under-ablation may result in complications during the treatments. An optimal solution is desired to have complete tumor coverage with minimal invasiveness, including minimal number of ablations and minimal number of perforation trajectories. As the planning of tumor ablation is a multi-objective problem, it is challenging to obtain optimal covering solutions based on clinician׳s experiences. Meanwhile, it is effective for computer-assisted systems to decide a set of optimal plans. This paper proposes a novel approach of integrating a computational optimization algorithm into the ablation planning system. The proposed ablation planning system is designed based on the following objectives: to achieve complete tumor coverage and to minimize the number of ablations, number of needle trajectories and over-ablation to the healthy tissue. These objectives are taken into account using a Genetic Algorithm, which is capable of generating feasible solutions within a constrained search space. The candidate ablation plans can be encoded in generations of chromosomes, which subsequently evolve based on a fitness function. In this paper, an exponential weight-criterion fitness function has been designed by incorporating constraint parameters that were reflective of the different objectives. According to the test results, the proposed planner is able to generate the set of optimal solutions for tumor ablation problem, thereby fulfilling the aforementioned multiple objectives.

  3. Femtosecond laser ablation profile near an interface: Analysis based on the correlation with superficial properties of individual materials

    Energy Technology Data Exchange (ETDEWEB)

    Nicolodelli, Gustavo, E-mail: nicolodelli@ursa.ifsc.usp.br [Instituto de Fisica de Sao Carlos, University of Sao Paulo, Grupo de Optica, Av. Trabalhador Sancarlense 400, P.O. Box 369, CEP 13560-970, Sao Carlos, SP (Brazil); Kurachi, Cristina; Bagnato, Vanderlei Salvador [Instituto de Fisica de Sao Carlos, University of Sao Paulo, Grupo de Optica, Av. Trabalhador Sancarlense 400, P.O. Box 369, CEP 13560-970, Sao Carlos, SP (Brazil)

    2011-01-15

    Femtosecond laser ablation of materials is turning to be an important tool for micromachining as well as for selective removal of biological tissues. In a great number of applications, laser ablation has to process through interfaces separating media of different properties. The investigation of the ablation behavior within materials and passing through interfaces is the main aim of this study. Especially, the analysis of the discontinuity in the ablation profile close to interfaces between distinct materials can reveal some of the phenomena involved in the formation of an ablated microcavity geometry. We have used a method that correlates the ablation cross sectional area with the local laser intensity. The effective intensity ablation properties were obtained from surface ablation data of distinct materials. The application of this method allows the prediction of the occurrence of a size discontinuity in the ablation geometry at the interface of distinct media, a fact which becomes important when planning applications in different media.

  4. Second generation endometrial ablation techniques: an audit of clinical practice.

    Science.gov (United States)

    Madhu, Chendrimada K; Nattey, Joseph; Naeem, Tahira

    2009-10-01

    To audit the practice and effectiveness of second generation endometrial ablation techniques (microwave and thermal balloon ablation). An audit of microwave and balloon endometrial ablation procedures was completed and performed during a 2-year period, in two district hospitals of Calderdale and Huddersfield NHS Trust, UK. Patients were followed up with for a maximum of 1 year postoperatively, or were referred again from their GPs, with symptoms. A questionnaire was also completed to evaluate patient satisfaction. About 136 and 59 women underwent balloon and microwave endometrial ablation, respectively (Total = 195), for heavy periods. By the end of year 1, 16% of patients were amenorrhoeic and 60% had lighter periods. About 15% of women did not have any relief of symptoms and needed a hysterectomy by 3 years. There were no statistically significant differences in the endometrial ablation techniques. There was no significant effect of age, body mass index, utero-cervical length, or the ablation technique on the results or the hysterectomy rates. A satisfaction survey showed that 75% of women felt better after the procedure and would recommend it to a close friend. Second generation ablation techniques are safe and effective methods of treating dysfunctional uterine bleeding, and are easy to use. They have reduced the incidence of hysterectomies and also have financial implications for healthcare providers.

  5. Combining Electrolysis and Electroporation for Tissue Ablation.

    Science.gov (United States)

    Phillips, Mary; Rubinsky, Liel; Meir, Arie; Raju, Narayan; Rubinsky, Boris

    2015-08-01

    Electrolytic ablation is a method that operates by delivering low magnitude direct current to the target region over long periods of time, generating electrolytic products that destroy cells. This study was designed to explore the hypothesis stating that electrolytic ablation can be made more effective when the electrolysis-producing electric charges are delivered using electric pulses with field strength typical in reversible electroporation protocols. (For brevity we will refer to tissue ablation protocols that combine electroporation and electrolysis as E(2).) The mechanistic explanation of this hypothesis is related to the idea that products of electrolysis generated by E(2) protocols can gain access to the interior of the cell through the electroporation permeabilized cell membrane and therefore cause more effective cell death than from the exterior of an intact cell. The goal of this study is to provide a first-order examination of this hypothesis by comparing the charge dosage required to cause a comparable level of damage to a rat liver, in vivo, when using either conventional electrolysis or E(2) approaches. Our results show that E(2) protocols produce tissue damage that is consistent with electrolytic ablation. Furthermore, E(2) protocols cause damage comparable to that produced by conventional electrolytic protocols while delivering orders of magnitude less charge to the target tissue over much shorter periods of time.

  6. Resonant holographic measurements of laser ablation plume expansion in vacuum and argon gas backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Lindley, R.A. [Michigan Univ., Ann Arbor, MI (United States)

    1993-10-01

    This thesis discusses the following on resonant holographic measurements of laser ablation plume expansion: Introduction to laser ablation; applications of laser ablation; The study of plume expansion; holographic interferometry; resonant holographic interferometry; accounting for finite laser bandwidth; The solution for doppler broadening and finite bandwidth; the main optical table; the lumonics laser spot shape; developing and reconstructing the holograms; plume expansion in RF/Plasma Environments; Determining {lambda}{sub o}; resonant refraction effects; fringe shift interpretation; shot-to-shot consistency; laser ablation in vacuum and low pressure, inert, background gas; theoretically modeling plume expansion in vacuum and low pressure, inert, background gas; and laser ablation in higher pressure, inert, background gas.

  7. Radiofrequency ablation of pulmonary tumors

    Energy Technology Data Exchange (ETDEWEB)

    Crocetti, Laura, E-mail: l.crocetti@med.unipi.i [Division of Diagnostic Imaging and Intervention, Department of Liver Transplants, Hepatology and Infectious Diseases, Pisa University School of Medicine (Italy); Lencioni, Riccardo [Division of Diagnostic Imaging and Intervention, Department of Liver Transplants, Hepatology and Infectious Diseases, Pisa University School of Medicine (Italy)

    2010-07-15

    The development of image-guided percutaneous techniques for local tumor ablation has been one of the major advances in the treatment of solid tumors. Among these methods, radiofrequency (RF) ablation is currently established as the primary ablative modality at most institutions. RF ablation is accepted as the best therapeutic choice for patients with early-stage hepatocellular carcinoma when liver transplantation or surgical resection are not suitable options and is considered as a viable alternate to surgery for inoperable patients with limited hepatic metastatic disease, especially from colorectal cancer. Recently, RF ablation has been demonstrated to be a safe and valuable treatment option for patients with unresectable or medically inoperable lung malignancies. Resection should remain the standard therapy for non-small cell lung cancer (NSCLC) but RF ablation may be better than conventional external-beam radiation for the treatment of the high-risk individual with NSCLC. Initial favourable outcomes encourage combining radiotherapy and RF ablation, especially for treating larger tumors. In the setting of colorectal cancer lung metastases, survival rates provided by RF ablation in selected patients, are substantially higher than those obtained with any chemotherapy regimens and provide indirect evidence that RF ablation therapy improves survival in patients with limited lung metastatic disease.

  8. Innovative techniques for image-guided ablation of benign thyroid nodules: Combined ethanol and radiofrequency ablation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Sun; Baek, Jung Hwan; Choi, Young Jun; Lee, Jeong Hyun [Dept. of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul (Korea, Republic of)

    2017-06-15

    In the treatment of benign thyroid nodules, ethanol ablation (EA), and radiofrequency ablation (RFA) have been suggested for cystic and solid thyroid nodules, respectively. Although combining these ablation techniques may be effective, no guidelines for or reviews of the combination have been published. Currently, there are three ways of combining EA and RFA: additional RFA is effective for treatment of incompletely resolved symptoms and solid residual portions of a thyroid nodule after EA. Additional EA can be performed for the residual unablated solid portion of a nodule after RFA if it is adjacent to critical structures (e.g., trachea, esophagus, and recurrent laryngeal nerve). In the concomitant procedure, ethanol is injected to control venous oozing after aspiration of cystic fluid prior to RFA of the remaining solid nodule.

  9. Sphere-Enhanced Microwave Ablation (sMWA) Versus Bland Microwave Ablation (bMWA): Technical Parameters, Specific CT 3D Rendering and Histopathology

    Energy Technology Data Exchange (ETDEWEB)

    Gockner, T. L., E-mail: theresa.gockner@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Zelzer, S., E-mail: s.zelzer@dkfz-heidelberg.de [German Cancer Research Center (dkfz), Medical and Biological Informatics (Germany); Mokry, T., E-mail: theresa.mokry@med.uni-heidelberg.de; Gnutzmann, D., E-mail: daniel.gnutzmann@med.uni-heidelberg.de; Bellemann, N., E-mail: nadine.bellemann@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Mogler, C., E-mail: carolin.mogler@med.uni-heidelberg.de [University Hospital Heidelberg, Department of General Pathology (Germany); Beierfuß, A., E-mail: anja.beierfuss@ethianum.de; Köllensperger, E., E-mail: eva.koellensperger@ethianum.de; Germann, G., E-mail: guenter.germann@ethianum.de [Ethianum Heidelberg, Clinic for Plastic Reconstructive Surgery and Aesthetic Surgery (Germany); Radeleff, B. A., E-mail: boris.radeleff@med.uni-heidelberg.de; Stampfl, U., E-mail: ulrike.stampfl@med.uni-heidelberg.de; Kauczor, H. U., E-mail: hu.kauczor@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Pereira, P. L., E-mail: philippe.pereira@slk-kliniken.de [SLK Kliniken Heilbronn GmbH, Clinic for Radiology, Minimally-invasive Therapies and Nuclear Medicine (Germany); Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de [University Hospital Heidelberg, Department of Diagnostic and Interventional Radiology (Germany)

    2015-04-15

    PurposeThis study was designed to compare technical parameters during ablation as well as CT 3D rendering and histopathology of the ablation zone between sphere-enhanced microwave ablation (sMWA) and bland microwave ablation (bMWA).MethodsIn six sheep-livers, 18 microwave ablations were performed with identical system presets (power output: 80 W, ablation time: 120 s). In three sheep, transarterial embolisation (TAE) was performed immediately before microwave ablation using spheres (diameter: 40 ± 10 μm) (sMWA). In the other three sheep, microwave ablation was performed without spheres embolisation (bMWA). Contrast-enhanced CT, sacrifice, and liver harvest followed immediately after microwave ablation. Study goals included technical parameters during ablation (resulting power output, ablation time), geometry of the ablation zone applying specific CT 3D rendering with a software prototype (short axis of the ablation zone, volume of the largest aligned ablation sphere within the ablation zone), and histopathology (hematoxylin-eosin, Masson Goldner and TUNEL).ResultsResulting power output/ablation times were 78.7 ± 1.0 W/120 ± 0.0 s for bMWA and 78.4 ± 1.0 W/120 ± 0.0 s for sMWA (n.s., respectively). Short axis/volume were 23.7 ± 3.7 mm/7.0 ± 2.4 cm{sup 3} for bMWA and 29.1 ± 3.4 mm/11.5 ± 3.9 cm{sup 3} for sMWA (P < 0.01, respectively). Histopathology confirmed the signs of coagulation necrosis as well as early and irreversible cell death for bMWA and sMWA. For sMWA, spheres were detected within, at the rim, and outside of the ablation zone without conspicuous features.ConclusionsSpecific CT 3D rendering identifies a larger ablation zone for sMWA compared with bMWA. The histopathological signs and the detectable amount of cell death are comparable for both groups. When comparing sMWA with bMWA, TAE has no effect on the technical parameters during ablation.

  10. Ablation of solids by femtosecond lasers ablation mechanism and ablation thresholds for metals and dielectrics

    CERN Document Server

    Gamaly, E G; Tikhonchuk, V T; Luther-Davies, B

    2001-01-01

    The mechanism of ablation of solids by intense femtosecond laser pulses is described in an explicit analytical form. It is shown that at high intensities when the ionization of the target material is complete before the end of the pulse, the ablation mechanism is the same for both metals and dielectrics. The physics of this new ablation regime involves ion acceleration in the electrostatic field caused by charge separation created by energetic electrons escaping from the target. The formulae for ablation thresholds and ablation rates for metals and dielectrics, combining the laser and target parameters, are derived and compared to experimental data. The calculated dependence of the ablation thresholds on the pulse duration is in agreement with the experimental data in a femtosecond range, and it is linked to the dependence for nanosecond pulses.

  11. Monopolar Radiofrequency Ablation for Medium-sized Hepatocellular Carcinoma: Preliminary Experience with Single-Electrode Overlapping Ablation and Multiple-Electrode Switching System

    Directory of Open Access Journals (Sweden)

    Shen-Yung Wang

    2015-03-01

    Conclusions: Medium-sized hepatocellular carcinoma can be effectively ablated with monopolar radiofrequency ablation by either single-electrode overlapping ablation or a multiple-electrode switching system. Regarding mid-term treatment responses, both RFA approaches can achieve similar treatment effectiveness, local tumor progression rate, and survival probabilities. Multiple-electrode switching RFA can treat larger medium-sized HCC with comparable mid-term efficacy as smaller medium-sized HCC treated with single-electrode overlapping RFA.

  12. Nonlinear ultrasonic phased array imaging of closed cracks using global preheating and local cooling

    Science.gov (United States)

    Ohara, Yoshikazu; Takahashi, Koji; Ino, Yoshihiro; Yamanaka, Kazushi

    2015-10-01

    Closed cracks are the main cause of underestimation in ultrasonic inspection, because the ultrasound transmits through the crack. Specifically, the measurement of closed-crack depth in coarse-grained materials, which are highly attenuative due to linear scatterings at the grains, is the most difficult issue. To solve this problem, we have developed a temporary crack opening method, global preheating and local cooling (GPLC), using tensile thermal stress, and a high-selectivity imaging method, load difference phased array (LDPA), based on the subtraction of phased array images between different stresses. To demonstrate our developed method, we formed a closed fatigue crack in coarse-grained stainless steel (SUS316L) specimen. As a result of applying it to the specimen, the high-selectivity imaging performance was successfully demonstrated. This will be useful in improving the measurement accuracy of closed-crack depths in coarse-grained material.

  13. Damage to preheated tungsten targets after multiple plasma impacts simulating ITER ELMs

    Energy Technology Data Exchange (ETDEWEB)

    Garkusha, I.E. [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine)], E-mail: garkusha@ipp.kharkov.ua; Bandura, A.N.; Byrka, O.V.; Chebotarev, V.V. [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine); Landman, I. [Forschungszentrum Karlsruhe, IHM, 76021 Karlsruhe (Germany); Makhlaj, V.A. [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine); Pestchanyi, S. [Forschungszentrum Karlsruhe, IHM, 76021 Karlsruhe (Germany); Tereshin, V.I. [Institute of Plasma Physics of the NSC KIPT, Akademicheskaya 1, 61108 Kharkov (Ukraine)

    2009-04-30

    The behavior of a preheated at 650 deg. C tungsten targets under repetitive ELM-like plasma pulses is studied in simulation experiments with the quasi-stationary plasma accelerator QSPA Kh-50. The targets have been exposed up to 350 pulses of the duration 0.25 ms and the surface heat loads either 0.45 MJ/m{sup 2} or 0.75 MJ/m{sup 2}, which is below and above the melting threshold, respectively. The development of surface morphology of the exposed targets as well as cracking and swelling at the surface is discussed. First comparisons of obtained experimental results with corresponding numerical simulations of the code PEGASUS-3D are presented.

  14. Comparison of Long-Term Effect of Dual-Chamber Pacing and Alcohol Septal Ablation in Patients with Hypertrophic Obstructive Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Jan Krejci

    2013-01-01

    Full Text Available Introduction. Nonpharmacological treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM comprises surgical myectomy (SME, alcohol septal ablation (ASA, and dual-chamber (DDD pacing. The aim of the study was to compare the long-term effect of DDD pacing and ASA in symptomatic HOCM patients. Patients and Methods. We evaluated retrospective data from three cardiocenters; there were 24 patients treated with DDD pacing included and 52 treated with ASA followed for 101 ± 49 and 87 ± 23 months, respectively. Results. In the group treated with DDD pacing, the left ventricle outflow tract gradient (LVOTG decreased from 82 ± 44 mmHg to 21 ± 21 mmHg, and NYHA class improved from 2.7 ± 0.5 to 2.1 ± 0.6 (both P<0.001. In the ASA-treated group, a decline in LVOTG from 73 ± 38 mmHg to 24 ± 26 mmHg and reduction in NYHA class from 2.8 ± 0.5 to 1.7 ± 0.8 were observed (both P<0.001. The LVOTG change was similar in both groups (P=0.264, and symptoms were more affected by ASA (P=0.001. Conclusion. ASA and DDD pacing were similarly effective in reducing LVOTG. The symptoms improvement was more expressed in patients treated with ASA.

  15. Ablation of solids by femtosecond lasers: ablation mechanism and ablation thresholds for metals and dielectrics

    OpenAIRE

    Gamaly, E. G.; Rode, A. V.; Tikhonchuk, V. T.; Luther-Davies, B.

    2001-01-01

    The mechanism of ablation of solids by intense femtosecond laser pulses is described in an explicit analytical form. It is shown that at high intensities when the ionization of the target material is complete before the end of the pulse, the ablation mechanism is the same for both metals and dielectrics. The physics of this new ablation regime involves ion acceleration in the electrostatic field caused by charge separation created by energetic electrons escaping from the target. The formulae ...

  16. Direct or coincidental elimination of stable rotors or focal sources may explain successful atrial fibrillation ablation: on-treatment analysis of the CONFIRM trial (Conventional ablation for AF with or without focal impulse and rotor modulation).

    Science.gov (United States)

    Narayan, Sanjiv M; Krummen, David E; Clopton, Paul; Shivkumar, Kalyanam; Miller, John M

    2013-07-09

    This study sought to determine whether ablation of recently described stable atrial fibrillation (AF) sources, either directly by Focal Impulse and Rotor Modulation (FIRM) or coincidentally when anatomic ablation passes through AF sources, may explain long-term freedom from AF. It is unclear why conventional anatomic AF ablation can be effective in some patients yet ineffective in others with similar profiles. The CONFIRM (Conventional Ablation for AF With or Without Focal Impulse and Rotor Modulation) trial prospectively revealed stable AF rotors or focal sources in 98 of 101 subjects with AF at 107 consecutive ablation cases. In 1:2 fashion, subjects received targeted source ablation (FIRM) followed by conventional ablation, or conventional ablation alone. We determined whether ablation lesions on electroanatomic maps passed through AF sources on FIRM maps. Subjects who completed follow-up (n = 94; 71.2% with persistent AF) showed 2.3 ± 1.1 concurrent AF rotors or focal sources that lay near pulmonary veins (22.8%), left atrial roof (16.0%), and elsewhere in the left (28.2%) and right (33.0%) atria. AF sources were ablated directly in 100% of FIRM cases and coincidentally (e.g., left atrial roof) in 45% of conventional cases (p sources were ablated but in only 18.2% of patients if sources were missed (p sources were ablated, intermediate if some sources were ablated, and lowest if no sources were ablated (p sources may explain freedom from AF after diverse approaches to ablation. Patient-specific AF source distributions are consistent with the reported success of specific anatomic lesion sets and of widespread ablation. These results support targeting AF sources to reduce unnecessary ablation, and motivate studies on FIRM-only ablation. Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  17. Femtosecond laser for cavity preparation in enamel and dentin: ablation efficiency related factors

    Science.gov (United States)

    Chen, H.; Li, H.; Sun, Yc.; Wang, Y.; Lü, Pj.

    2016-02-01

    To study the effects of laser fluence (laser energy density), scanning line spacing and ablation depth on the efficiency of a femtosecond laser for three-dimensional ablation of enamel and dentin. A diode-pumped, thin-disk femtosecond laser (wavelength 1025 nm, pulse width 400 fs) was used for the ablation of enamel and dentin. The laser spot was guided in a series of overlapping parallel lines on enamel and dentin surfaces to form a three-dimensional cavity. The depth and volume of the ablated cavity was then measured under a 3D measurement microscope to determine the ablation efficiency. Different values of fluence, scanning line spacing and ablation depth were used to assess the effects of each variable on ablation efficiency. Ablation efficiencies for enamel and dentin were maximized at different laser fluences and number of scanning lines and decreased with increases in laser fluence or with increases in scanning line spacing beyond spot diameter or with increases in ablation depth. Laser fluence, scanning line spacing and ablation depth all significantly affected femtosecond laser ablation efficiency. Use of a reasonable control for each of these parameters will improve future clinical application.

  18. UV laser ablation patterns in intraocular lenses

    Science.gov (United States)

    Lagiou, D. P.; Evangelatos, Ch.; Apostolopoulos, A.; Spyratou, E.; Bacharis, C.; Makropoulou, M.; Serafetinides, A. A.

    2013-03-01

    The aim of this work is to investigate the effect of UV solid state laser radiation on intraocular lens (IOL) polymer surfaces as an alternative method to conventional surface shaping techniques for IOLs customization. Laser ablation experiments were performed on PMMA plates and commercially available hydrophobic and hydrophilic acrylic IOLs with the 5th harmonic of a Q-switched Nd:YAG laser (λ=213 nm). Circular arrays of holes were drilled on the polymer surface, covering the centre and the peripheries of the IOL. The morphology of the ablated IOL surface was examined with a conventional optical microscope (Leitz GMBH Wetzlar) and with a scanning electron microscope (SEM, Fei - Innova Nanoscope) at various laser parameters. Quantitative measurements of ablation rates were performed with a contact profilometer (Dektak-150), in which a mechanical stylus scanned across the surface of gold-coated IOLs (after SEM imaging) to measure variationsF in surface height. Laser interaction with IOLs depends on optical and mechanical material properties, in addition to laser radiation parameters. The exact ablation mechanism is discussed. Some polymer materials, depending on their properties, are more susceptible to the photothermal mechanism than the photochemical one or vice versa. In summary, every IOL polymer exhibits specific attributes in its interaction with the 5th harmonic of Nd:YAG laser.

  19. Outpatient laser tonsillar ablation under local anaesthetic.

    Science.gov (United States)

    Andrews, Peter J; Latif, Abdul

    2004-11-01

    Outpatient laser ablation of the palatine tonsils under local anaesthetic is an alternative technique to capsular tonsillectomy for recurrent tonsillitis under general anaesthetic. Laser tonsillotomy ablates up to 70% of the tonsillar tissue and is performed when patients choose not to have a conventional tonsillectomy, or are unfit for a general anaesthetic. The technique described here is an adaptation of Krespis' laser-assisted serial tonsillectomy (LAST) whereby only one sitting is required. Krespis' technique effectively eliminates recurrent tonsillitis in 96% of the cases over a 4-year follow-up period and represents the only substantial study looking at treating recurrent tonsillitis with outpatient laser ablation. This study is a retrospective postal survey of 19 patients who underwent laser tonsillar ablation under local anaesthetic for recurrent chronic tonsillitis from 1997 to 2001 and was performed in liaison with the clinical audit department at Basildon Hospital. We had a response rate of 74% and an admission rate of 0%, which compares favourably with day case tonsillectomy surgery. Of the patients, 75% did not experience further episodes of tonsillitis 12 months after the procedure and 77% of the patients were glad they had the operation. Although this technique does not completely eliminate tonsillitis, it offers an alternative for those patients who prefer a procedure that is done quickly in an outpatient setting without the additional problems of general anaesthesia, overnight hospital admission and long waiting lists.

  20. WE-EF-BRA-03: Catheter- Free Ablation with External Photon Radiation: Treatment Planning, Delivery Considerations, and Correlation of Effects with Delivered Dose

    Energy Technology Data Exchange (ETDEWEB)

    Deisher, A; Anderson, S; Cusma, J; Herman, M; Johnson, S; Lehmann, H; Packer, D; Parker, K; Song, L; Takami, M; Kruse, J [Mayo Clinic, Rochester, MN (United States)

    2015-06-15

    Purpose: To plan, target, and calculate delivered dose in atrioventricular node (AVN) ablation with volume-modulated arc therapy (VMAT) in an intact porcine model. Methods: Seven pigs underwent AVN irradiation, with prescription doses ranging between 25 and 55Gy in a single fraction. Cardiac CT scans were acquired at expiration. Two physicians contoured AVN targets on 10 phases, providing estimates of target motion and inter-physician variability. Treatment planning was conducted on a static phase-averaged CT. The volume designated to receive prescription dose covered the full extent of AVN cardiac motion, expanded by 4mm for setup uncertainty. Optimization limited doses to risk structures according to single-fraction tumor treatment protocols. Orthogonal kV images were used to align bony anatomy at time of treatment. Localization was further refined with respiratory-gated cone-beam CT, and range of cardiac motion was verified under fluoroscopy. Beam delivery was respiratory-gated for expiration with a mean efficiency of 60%. Deformable registration of the 10 cardiac CT phases was used to calculate actual delivered dose for comparison to electro-anatomical and visually evident lesions. Results: The mean [minimum,maximum] amplitude of AVN cardiac motion was LR 2.9 [1.7,3.9]mm, AP 6.6 [4.4,10.4]mm, and SI 5.6 [2.0,9.9]mm. Incorporating cardiac motion into the dose calculation showed the volume receiving full dose was 40–80% of the volume indicated on the static planning image, although the contoured AVN target received full dose in all animals. Initial results suggest the dimensions of the electro-anatomical lesion are correlated with the 40Gy isodose volume. Conclusion: Image-guidance techniques allow for accurate and precise delivery of VMAT for catheter-free arrhythmia ablation. An arsenal of advanced radiation planning, dose optimization, and image-guided delivery techniques was employed to assess and mitigate effects of cardiac and respiratory motion

  1. Ablation response testing of simulated radioisotope power supplies

    Science.gov (United States)

    Lutz, Steven A.; Chan, Chris C.

    1994-05-01

    Results of an experimental program to assess the aerothermal ablation response of simulated radioisotope power supplies are presented. Full-scale general purpose heat source, graphite impact shell, and lightweight radioisotope heater unit test articles are all tested without nuclear fuel in simulated reentry environments. Convective stagnation heating, stagnation pressure, stagnation surface temperature, surface recession profile, and weight loss measurements are obtained for diffusion-limited and sublimation ablation conditions. The recession profile and weight loss measurements show an effect of surface features on the stagnation face. The surface features alter the local heating which in turn affects the local ablation.

  2. Laser Ablation for Cancer: Past, Present and Future

    Science.gov (United States)

    Schena, Emiliano; Saccomandi, Paola; Fong, Yuman

    2017-01-01

    Laser ablation (LA) is gaining acceptance for the treatment of tumors as an alternative to surgical resection. This paper reviews the use of lasers for ablative and surgical applications. Also reviewed are solutions aimed at improving LA outcomes: hyperthermal treatment planning tools and thermometric techniques during LA, used to guide the surgeon in the choice and adjustment of the optimal laser settings, and the potential use of nanoparticles to allow biologic selectivity of ablative treatments. Promising technical solutions and a better knowledge of laser-tissue interaction should allow LA to be used in a safe and effective manner as a cancer treatment. PMID:28613248

  3. Radiofrequency ablation of atrial fibrillation

    NARCIS (Netherlands)

    Wiesfeld, ACP; Tan, ES; Van Veldhuisen, DJ; Crijns, HJGM; Van Gelder, IC

    2004-01-01

    Twenty-five patients (16 males, mean age 46 years.) underwent radiofrequency ablation because of either paroxysmal (13 patients) or persistent atrial fibrillation (12 patients). Ablation aimed at earliest activation of spontaneous and catheter-induced repetitive ectopy in left and right atria and ap

  4. Laser ablation in analytical chemistry.

    Science.gov (United States)

    Russo, Richard E; Mao, Xianglei; Gonzalez, Jhanis J; Zorba, Vassilia; Yoo, Jong

    2013-07-02

    In 2002, we wrote an Analytical Chemistry feature article describing the Physics of Laser Ablation in Microchemical Analysis. In line with the theme of the 2002 article, this manuscript discusses current issues in fundamental research, applications based on detecting photons at the ablation site (LIBS and LAMIS) and by collecting particles for excitation in a secondary source (ICP), and directions for the technology.

  5. Ablation-cooled material removal with ultrafast bursts of pulses

    Science.gov (United States)

    Kerse, Can; Kalaycıoğlu, Hamit; Elahi, Parviz; Çetin, Barbaros; Kesim, Denizhan K.; Akçaalan, Önder; Yavaş, Seydi; Aşık, Mehmet D.; Öktem, Bülent; Hoogland, Heinar; Holzwarth, Ronald; Ilday, Fatih Ömer

    2016-09-01

    The use of femtosecond laser pulses allows precise and thermal-damage-free removal of material (ablation) with wide-ranging scientific, medical and industrial applications. However, its potential is limited by the low speeds at which material can be removed and the complexity of the associated laser technology. The complexity of the laser design arises from the need to overcome the high pulse energy threshold for efficient ablation. However, the use of more powerful lasers to increase the ablation rate results in unwanted effects such as shielding, saturation and collateral damage from heat accumulation at higher laser powers. Here we circumvent this limitation by exploiting ablation cooling, in analogy to a technique routinely used in aerospace engineering. We apply ultrafast successions (bursts) of laser pulses to ablate the target material before the residual heat deposited by previous pulses diffuses away from the processing region. Proof-of-principle experiments on various substrates demonstrate that extremely high repetition rates, which make ablation cooling possible, reduce the laser pulse energies needed for ablation and increase the efficiency of the removal process by an order of magnitude over previously used laser parameters. We also demonstrate the removal of brain tissue at two cubic millimetres per minute and dentine at three cubic millimetres per minute without any thermal damage to the bulk.

  6. Actual role of radiofrequency ablation of liver metastases

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Philippe L. [Eberhard-Karls-University of Tuebingen, Department of Diagnostic Radiology, Tuebingen (Germany)

    2007-08-15

    The liver is, second only to lymph nodes, the most common site for metastatic disease irrespective of the primary tumour. More than 50% of all patients with malignant diseases will develop liver metastases with a significant morbidity and mortality. Although the surgical resection leads to an improved survival in patients with colorectal metastases, only approximately 20% of patients are eligible for surgery. Thermal ablation and especially radiofrequency ablation emerge as an important additional therapy modality for the treatment of liver metastases. RF ablation shows a benefit in life expectancy and may lead in a selected patient group to cure. Percutaneous RF ablation appears safer (versus cryotherapy), easier (versus laser), and more effective (versus ethanol instillation and transarterial chemoembolisation) compared with other minimally invasive procedures. RF ablation can be performed by a percutaneous, laparoscopical or laparotomic approach, and may be potentially combined with chemotherapy and surgery. At present ideal candidates have tumours with a maximum diameter less than 3.5 cm. An untreatable primary tumour or a systemic disease represents contraindications for performing local therapies. Permanent technical improvements of thermal ablation devices and a better integration of thermal ablation in the overall patient care may lead to prognosis improvement in patients with liver metastases. (orig.)

  7. 垃圾焚烧发电厂一次风预热方式的比较分析%Comparison of Preheating Ways of Primary Air in Waste Incineration Power Plants

    Institute of Scientific and Technical Information of China (English)

    李军; 严圣军; 陈竹; 王占磊

    2012-01-01

    A comparison of heating medium in phase II of primary air preheater by ways of superheat steam and drum saturated steam for waste incineration power plants were carried out. The results showed that comparing with drum saturated steam, the weight of steam extraction with superheat steam decreased by 20. 8%, the heat quantity decreased by 8. 7%, the steam flow into the turbine increased, the heat exchanging area in phase II of the preheater can be reduced by about 20%, and the cost can be reduced by about 10%. The superheat steam has advantages of small investment cost, small steam consumption, and higher heat effective utilization. According to waste characteristic, incineration scale and control policy, it could give a reference to select preheat way of primary air, with the new ideas of primary air preheated by boiler feed water and the optimized air preheating way.%对垃圾焚烧发电厂一次风加热器Ⅱ段的加热介质采用锅炉出口过热蒸汽和汽包饱和蒸汽进行比较,结果表明:过热蒸汽抽汽较汽包饱和蒸汽抽汽的抽汽量减少20.8%,热量减少8.7%,并增加了进汽机的蒸汽量,同时预热器Ⅱ段换热面积可减少约20%,造价相应降低约10%.过热蒸汽加热有投资成本小、蒸汽耗量小、热量有效利用率高的优点.并通过锅炉给水预热一次风、优化的空气预热方式等新的一次风预热思路,供不同垃圾性质、焚烧规模、控制策略等选择一次风预热形式时参考.

  8. [Moist ablation of the corneal surface with the Er:YAG laser. Results of optimizing ablation].

    Science.gov (United States)

    Bende, T; Jean, B; Matallana, M; Seiler, T; Steiner, R

    1994-10-01

    The Er:YAG laser, emitting light at 2.94 microns, may be an alternative to the 193 nm excimer laser for photorefractive keratectomy. Compared to the excimer laser, the ablation rate is very high. Surface roughness is also more pronounced than for the excimer laser. Using a precorneal liquid film, these two factors can be reduced, as shown in ablation experiments performed on porcine corneas. Thermal damage of the remaining corneal tissue is another side effect. There is no significant decrease in the amount of thermal damage with this new technique,--not even when the pulse length is reduced.

  9. A chemical model of meteoric ablation

    Directory of Open Access Journals (Sweden)

    T. Vondrak

    2008-12-01

    Full Text Available Most of the extraterrestrial dust entering the Earth's atmosphere ablates to produce metal vapours, which have significant effects on the aeronomy of the upper mesosphere and lower thermosphere. A new Chemical Ablation Model (CAMOD is described which treats the physics and chemistry of ablation, by including the following processes: sputtering by inelastic collisions with air molecules before the meteoroid melts; evaporation of atoms and oxides from the molten particle; diffusion-controlled migration of the volatile constituents (Na and K through the molten particle; and impact ionization of the ablated fragments by hyperthermal collisions with air molecules. Evaporation is based on thermodynamic equilibrium in the molten meteoroid (treated as a melt of metal oxides, and between the particle and surrounding vapour phase. The loss rate of each element is then determined assuming Langmuir evaporation. CAMOD successfully predicts the meteor head echo appearance heights, observed from incoherent scatter radars, over a wide range of meteoroid velocities. The model also confirms that differential ablation explains common-volume lidar observations of K, Ca and Ca+ in fresh meteor trails. CAMOD is then used to calculate the injection rates into the atmosphere of a variety of elements as a function of altitude, integrated over the meteoroid mass and velocity distributions. The most abundant elements (Fe, Mg and Si have peak injection rates around 85 km, with Na and K about 8 km higher. The more refractory element Ca ablates around 82 km with a Na:Ca ratio of 4:1, which does therefore not explain the depletion of atomic Ca to Na, by more than 2 orders of magnitude, in the upper mesosphere. Diffusion of the most volatile elements (Na and K does not appear to be rate-limiting except in the fastest meteoroids. Non-thermal sputtering causes ~35% mass loss from the fastest (~60–70 km s−1 and smallest (10−17–10

  10. A chemical model of meteoric ablation

    Directory of Open Access Journals (Sweden)

    T. Vondrak

    2008-07-01

    Full Text Available Most of the extraterrestrial dust entering the Earth's atmosphere ablates to produce metal vapours, which have significant effects on the aeronomy of the upper mesosphere and lower thermosphere. A new Chemical Ablation Model (CAMOD is described which treats the physics and chemistry of ablation, by including the following processes: sputtering by inelastic collisions with air molecules before the meteoroid melts; evaporation of atoms and oxides from the molten particle; diffusion-controlled migration of the volatile constituents (Na and K through the molten particle; and impact ionization of the ablated fragments by hyperthermal collisions with air molecules. Evaporation is based on thermodynamic equilibrium in the molten meteoroid (treated as a melt of metal oxides, and between the particle and surrounding vapour phase. The loss rate of each element is then determined assuming Langmuir evaporation. CAMOD successfully predicts the meteor head echo appearance heights, observed from incoherent scatter radars, over a wide range of meteoroid velocities. The model also confirms that differential ablation explains common-volume lidar observations of K, Ca and Ca+ in fresh meteor trails. CAMOD is then used to calculate the injection rates into the atmosphere of a variety of elements as a function of altitude, integrated over the meteoroid mass and velocity distributions. The most abundant elements (Fe, Mg and Si have peak injection rates around 85 km, with Na and K about 8 km higher. The more refractory element Ca ablates around 82 km with a Na:Ca ratio of 4:1, which does therefore not explain the depletion of atomic Ca to Na, by more than 2 orders of magnitude, in the upper mesosphere. Diffusion of the most volatile elements (Na and K does not appear to be rate-limiting except in the fastest meteoroids. Non-thermal sputtering causes ~35% mass loss from the fastest (~60–70 km s−1 and smallest (10−17–10

  11. He, U, and Th Depth Profiling of Apatite and Zircon Using Laser Ablation Noble Gas Mass Spectrometry and SIMS

    Science.gov (United States)

    Monteleone, B. D.; van Soest, M. C.; Hodges, K. V.; Hervig, R.; Boyce, J. W.

    2008-12-01

    Conventional (U-Th)/He thermochronology utilizes single or multiple grain analyses of U- and Th-bearing minerals such as apatite and zircon and does not allow for assessment of spatial variation in concentration of He, U, or Th within individual crystals. As such, age calculation and interpretation require assumptions regarding 4He loss through alpha ejection, diffusive redistribution of 4He, and U and Th distribution as an initial condition for these processes. Although models have been developed to predict 4He diffusion parameters, correct for the effect of alpha ejection on calculated cooling ages, and account for the effect of U and Th zonation within apatite and zircon, measurements of 4He, U, and Th distribution have not been combined within a single crystal. We apply ArF excimer laser ablation, combined with noble gas mass spectrometry, to obtain depth profiles within apatite and zircon crystals in order to assess variations in 4He concentration with depth. Our initial results from pre-cut, pre-heated slabs of Durango apatite, each subjected to different T-t schedules, suggest a general agreement of 4He profiles with those predicted by theoretical diffusion models (Farley, 2000). Depth profiles through unpolished grains give reproducible alpha ejection profiles in Durango apatite that deviate from alpha ejection profiles predicted for ideal, homogenous crystals. SIMS depth profiling utilizes an O2 primary beam capable of sputtering tens of microns and measuring sub-micron resolution variation in [U], [Th], and [Sm]. Preliminary results suggest that sufficient [U] and [Th] zonation is present in Durango apatite to influence the form of the 4He alpha ejection profile. Future work will assess the influence of measured [U] and [Th] zonation on previously measured 4He depth profiles. Farley, K.A., 2000. Helium diffusion from apatite; general behavior as illustrated by Durango fluorapatite. J. Geophys. Res., B Solid Earth Planets 105 (2), 2903-2914.

  12. Optimization of the generator settings for endobiliary radiofrequency ablation

    Institute of Scientific and Technical Information of China (English)

    Maximilien; Barret; Sarah; Leblanc; Ariane; Vienne; Alexandre; Rouquette; Frederic; Beuvon; Stanislas; Chaussade; Frederic; Prat

    2015-01-01

    AIM:To determine the optimal generator settings for endobiliary radiofrequency ablation. METHODS:Endobiliary radiofrequency ablation was performed in live swine on the ampulla of Vater,the common bile duct and in the hepatic parenchyma. Radiofrequency ablation time,"effect",and power were allowed to vary. The animals were sacrificed two hours after the procedure. Histopathological assessment of the depth of the thermal lesions was performed. RESULTS:Twenty-five radiofrequency bursts were applied in three swine. In the ampulla of Vater(n = 3),necrosis of the duodenal wall was observed starting with an effect set at 8,power output set at 10 W,and a 30 s shot duration,whereas superficial mucosal damage of up to 350 μm in depth was recorded for an effect set at 8,power output set at 6 W and a 30 s shot duration. In the common bile duct(n = 4),a 1070 μm,safe and efficient ablation was obtained for an effect set at 8,a power output of 8 W,and an ablation time of 30 s. Within the hepatic parenchyma(n = 18),the depth of tissue damage varied from 1620 μm(effect = 8,power = 10 W,ablation time = 15 s) to 4480 μm(effect = 8,power = 8 W,ablation time = 90 s). CONCLUSION:The duration of the catheter application appeared to be the most important parameter influencing the depth of the thermal injury during endobiliary radiofrequency ablation. In healthy swine,the currently recommended settings of the generator may induce severe,supratherapeutic tissue damage in the biliary tree,especially in the high-risk area of the ampulla of Vater.

  13. Meta-analysis of bipolar radiofrequency endometrial ablation versus thermal balloon endometrial ablation for the treatment of heavy menstrual bleeding.

    Science.gov (United States)

    Zhai, Yan; Zhang, Zihan; Wang, Wei; Zheng, Tingping; Zhang, Huili

    2017-10-06

    Heavy menstrual bleeding is a common problem that can severely affect quality of life. To compare bipolar radiofrequency endometrial ablation and thermal balloon ablation for heavy menstrual bleeding in terms of efficacy and health-related quality of life (HRQoL). Online registries were systematically searched using relevant terms without language restriction from inception to November 24, 2016. Randomized control trials or cohort studies of women with heavy menstrual bleeding comparing the efficacy of two treatments were eligible. Data were extracted. Results were expressed as risk ratios (RRs) or weighted mean differences (WMDs) with 95% confidence intervals (CIs). Six studies involving 901 patients were included. Amenorrhea rate at 12 months was significantly higher after bipolar radiofrequency endometrial ablation than after thermal balloon ablation (RR 2.73, 95% CI 2.00-3.73). However, no difference at 12 months was noted for dysmenorrhea (RR 1.04, 95% CI 0.68-1.58) or treatment failure (RR 0.78, 95% CI 0.38-1.60). The only significant difference for HRQoL outcomes was for change in SAQ pleasure score (12 months: WMD -3.51, 95% CI -5.42 to -1.60). Bipolar radiofrequency endometrial ablation and thermal balloon ablation reduce menstrual loss and improve quality of life. However, bipolar radiofrequency endometrial ablation is more effective in terms of amenorrhea rate and SAQ pleasure. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  14. Micrometeorological processes driving snow ablation in an Alpine catchment

    Directory of Open Access Journals (Sweden)

    R. Mott

    2011-11-01

    Full Text Available Mountain snow covers typically become patchy over the course of a melting season. The snow pattern during melt is mainly governed by the end of winter snow depth distribution and the local energy balance. The objective of this study is to investigate micro-meteorological processes driving snow ablation in an Alpine catchment. For this purpose we combine a meteorological boundary-layer model (Advanced Regional Prediction System with a fully distributed energy balance model (Alpine3D. Turbulent fluxes above melting snow are further investigated by using data from eddy-correlation systems. We compare modeled snow ablation to measured ablation rates as obtained from a series of Terrestrial Laser Scanning campaigns covering a complete ablation season. The measured ablation rates indicate that the advection of sensible heat causes locally increased ablation rates at the upwind edges of the snow patches. The effect, however, appears to be active over rather short distances of about 4–6 m. Measurements suggest that mean wind velocities of about 5 m s−1 are required for advective heat transport to increase snow ablation over a long fetch distance of about 20 m. Neglecting this effect, the model is able to capture the mean ablation rates for early ablation periods but strongly overestimates snow ablation once the fraction of snow coverage is below a critical value of approximately 0.6. While radiation dominates snow ablation early in the season, the turbulent flux contribution becomes important late in the season. Simulation results indicate that the air temperatures appear to overestimate the local air temperature above snow patches once the snow coverage is low. Measured turbulent fluxes support these findings by suggesting a stable internal boundary layer close to the snow surface causing a strong decrease of the sensible heat flux towards the snow cover. Thus, the existence of a stable internal boundary layer above a patchy snow cover

  15. A Numerical Analysis of the Transient Response of an Ablation System Including Effects of Thermal Nonequilibrium, Mass Transfer and Chemical Kinetics. Ph.D Thesis - Virginia Polytechnic Inst. and State Univ.

    Science.gov (United States)

    Clark, R. K.

    1972-01-01

    The differential equations governing the transient response of a one-dimensional ablative thermal protection system undergoing stagnation ablation are derived. These equations are for thermal nonequilibrium effects between the pyrolysis gases and the char layer and kinetically controlled chemical reactions and mass transfer between the pyrolysis gases and the char layer. The boundary conditions are written for the particular case of stagnation heating with surface removal by oxidation or sublimation and pyrolysis of the uncharred layer occurring in a plane. The governing equations and boundary conditions are solved numerically using the modified implicit method (Crank-Nicolson method). Numerical results are compared with exact solutions for a number of simplified cases. The comparison is favorable in each instance.

  16. Cost-effectiveness of using recombinant human thyroid-stimulating hormone before radioiodine ablation for thyroid cancer treatment in Spanish hospitals.

    Science.gov (United States)

    Vallejo, J A; Muros, M A

    2017-05-20

    In thyroid cancer treatment, the thyroid-stimulating hormone (TSH) must be elevated before radioiodine ablation, either by exogenous (with recombinant human thyrotropin [rhTSH]) or endogenous stimulation by thyroid hormone withdrawal (THW). The use of rhTSH avoids hypothyroidism and favours the subsequent elimination of radioiodine, but involves the cost of the product. For this reason, a cost-effectiveness analysis was performed, taking into account all costs involved and the benefits associated with the use of this therapy. Using a Markov modelling with two analysis arms (rhTSH and THW), stratified into high (100mCi/3700 MBq) and low (30mCi/1110 MBq) radioiodine doses, and using 17 weekly cycles, the incremental cost per quality-adjusted life-year (QALY) related to the use of rhTSH was determined. The clinical inputs included in the model were based on published studies and in a treatment survey conducted in Spain. Radioablation preparation with rhTSH is superior to THW, showing additional benefits (0.048 AVAC), as well as cost savings (-€614.16), with an incremental cost-effectiveness rate (ICER) of -€12,795/QALY. The univariate and multivariate sensitivity analyses showed the result to be robust. The use of rhTSH previous to radioablation in Spain has cost savings, as well as a series of health benefits for the patient, making it highly cost-effective. Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

  17. Effect of different breathing patterns in the same patient on stereotactic ablative body radiotherapy dosimetry for primary renal cell carcinoma: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Daniel, E-mail: Daniel.Pham@petermac.org [Radiotherapy Services, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Kron, Tomas [Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia); Foroudi, Farshad; Siva, Shankar [Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria (Australia)

    2013-10-01

    Stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) targets requires motion management strategies to verify dose delivery. This case study highlights the effect of a change in patient breathing amplitude on the dosimetry to organs at risk and target structures. A 73-year-old male patient was planned for receiving 26 Gy of radiation in 1 fraction of SABR for a left primary RCC. The patient was simulated with four-dimensional computed tomography (4DCT) and the tumor internal target volume (ITV) was delineated using the 4DCT maximum intensity projection. However, the initially planned treatment was abandoned at the radiation oncologist's discretion after pretreatment cone-beam CT (CBCT) motion verification identified a greater than 50% reduction in superior to inferior diaphragm motion as compared with the planning 4DCT. This patient was resimulated with respiratory coaching instructions. To assess the effect of the change in breathing on the dosimetry to the target, each plan was recalculated on the data set representing the change in breathing condition. A change from smaller to larger breathing showed a 46% loss in planning target volume (PTV) coverage, whereas a change from larger breathing to smaller breathing resulted in an 8% decrease in PTV coverage. ITV coverage was similarly reduced by 8% in both scenarios. This case study highlights the importance of tools to verify breathing motion prior to treatment delivery. 4D image guided radiation therapy verification strategies should focus on not only verifying ITV margin coverage but also the effect on the surrounding organs at risk.

  18. Effect of different breathing patterns in the same patient on stereotactic ablative body radiotherapy dosimetry for primary renal cell carcinoma: a case study.

    Science.gov (United States)

    Pham, Daniel; Kron, Tomas; Foroudi, Farshad; Siva, Shankar

    2013-01-01

    Stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) targets requires motion management strategies to verify dose delivery. This case study highlights the effect of a change in patient breathing amplitude on the dosimetry to organs at risk and target structures. A 73-year-old male patient was planned for receiving 26Gy of radiation in 1 fraction of SABR for a left primary RCC. The patient was simulated with four-dimensional computed tomography (4DCT) and the tumor internal target volume (ITV) was delineated using the 4DCT maximum intensity projection. However, the initially planned treatment was abandoned at the radiation oncologist's discretion after pretreatment cone-beam CT (CBCT) motion verification identified a greater than 50% reduction in superior to inferior diaphragm motion as compared with the planning 4DCT. This patient was resimulated with respiratory coaching instructions. To assess the effect of the change in breathing on the dosimetry to the target, each plan was recalculated on the data set representing the change in breathing condition. A change from smaller to larger breathing showed a 46% loss in planning target volume (PTV) coverage, whereas a change from larger breathing to smaller breathing resulted in an 8% decrease in PTV coverage. ITV coverage was similarly reduced by 8% in both scenarios. This case study highlights the importance of tools to verify breathing motion prior to treatment delivery. 4D image guided radiation therapy verification strategies should focus on not only verifying ITV margin coverage but also the effect on the surrounding organs at risk.

  19. The characteristics of confined ablation in laser propulsion

    Institute of Scientific and Technical Information of China (English)

    Zheng Zhi-Yuan; Zhang Jie; Hao Zuo-Qiang; Yuan Xiao-Hui; Zhang Zhe; Lu Xin; Wang Zhao-Hua; Wei Zhi-Yi

    2006-01-01

    Compared with direct ablation, confined ablation provides an effective way to obtain a large target momentum and a high coupling coefficient. By using a transparent glass layer to cover the target surface, the coupling coefficient is enhanced by an order of magnitude. With the increase of the gap width between the target surface and the cover layer, the coupling coefficient exponentially decreases. It is found that the coupling coefficient is also related to the thickness of the cover layer.

  20. Shock experiments on pre-heated alpha- and beta-quartz: 1. Optical and density data

    Science.gov (United States)

    Langenhorst, Falko; Deutsch, Alexander

    1994-07-01

    Discs of single crystal quartz, unheated, and pre-heated to 275 C and 540 C (i.e., alpha-quartz) and 630 C (i.e., beta-quartz) were experimentally shocked to pressures ranging from 20 to 40 GPa, with the shock front propagating parallel to either (10-10) or (0001). Refractive indices, density and the orientation of planar deformation features (PDFs) were determined on the recovered quartz samples. Refractive indices of pre-heated quartz are unaffected up to 25 GPa but density starts to decrease slightly up to this pressure. Above 25 GPa, pre-heating causes drastic variations: Refractive indices and birefringence of quartz shocked at ambient temperature decrease continuously, until complete isotropization is reached at 35 GPa. In quartz shocked at 630 C, refractivity drops discontinuously in the interval from 25 to 26 GPa, and complete transformation to diaplectic glass is reached at 26 GPa. Density follows the trends demonstrated by the optical parameters, with higher pre-shock temperatures yielding lower density at a given shock pressure. These results indicate that the threshold pressure for the onset of transformation to diaplectic quartz glass is largely temperature-invariant, lying at 25 GPa, whereas the pressure limit for complete transformation decreases with increasing pre-shock temperature from approximately equal 35 to approximately equal 26 GPa. Quartz shocked parallel to (0001) always has a higher density and refractivity than that shocked parallel to (10-10), indicating a significant influence of the structural anisotropy. This is also evident from the distribution of PDF orientations. Pressures greater than or equal 25 GPa cause, in quartz shocked parallel to (10-10), PDFs that are predominantly oriented parallel to set of (10-12) planes, while quartz shocked to the same pressures but parallel to (0001) contains almost exclusively PDFs parallel to set of (10-13) planes. PDF orientations in quartz shocked at ambient temperature parallel to (10-10) show

  1. Effects of percutaneous transluminal septal myocardial ablation for obstructive hypertrophic cardiomyopathy on systolic and diastolic left ventricular function assessed by pressure-volume loops.

    Science.gov (United States)

    Meliga, Emanuele; Steendijk, Paul; Valgimigli, Marco; Ten Cate, Folkert J; Serruys, Patrick W

    2008-04-15

    The aim of the present study was to determine the long-term effects of percutaneous transluminal septal myocardial ablation (PTSMA) on systolic and diastolic left ventricular (LV) functions in patients with obstructive hypertrophic cardiomyopathy (HC). Ten consecutive patients with symptomatic HC despite optimal medical treatment were referred for PTSMA at our center. LV systolic and diastolic functions were assessed by online LV pressure-volume loops obtained by conductance catheter at baseline and at 6 months after the procedure. At follow-up, the mean gradients at rest and after extrasystole were significantly decreased compared with baseline (88 +/- 29 to 21 +/- 11 mm Hg and 130 +/- 50 to 35 +/- 22 mm Hg, respectively, p <0.01 for the 2 comparisons). End-systolic and end-diastolic pressures significantly decreased (p <0.01), whereas end-systolic and end-diastolic LV volumes significantly increased (p <0.01 for the 2 comparisons). Cardiac output and stroke volume were unchanged, as were ejection fraction (p = 0.25) and maximum dP/dt (p = 0.13). The slope of the end-systolic pressure-volume relation was not decreased, indicating a preserved contractility. The relaxation constant time, end-diastolic stiffness, projected volume of the end-diastolic pressure-volume relation at 30 mm Hg, and diastolic stiffness constant showed a significant improvement of active and passive myocardial diastolic properties. In conclusion, PTSMA is an effective method in the treatment of symptomatic patients with HC. At 6-month follow-up, the LV-aortic gradient was decreased and active and passive LV diastolic properties were increased. Myocardial contractility was not decreased and general hemodynamics was maintained.

  2. Experimental Study on the Effect of High-intensity Focused Ultrasound (HIFU) Using Sonablate-500 in the Ablation of Canine Prostate

    Institute of Scientific and Technical Information of China (English)

    LU Jun; YE Zhangqun; WANG Wei; CHEN Zhaoyang; ZHANG Yuanfeng; HU Weilie

    2007-01-01

    To investigate the safety, feasibility and effectiveness of transrectal high-intensity focused ultrasound (HIFU) in the ablation of canine prostate, 20 dogs were divided randomly into 5 groups.Sixteen canine prostates were treated with the third-generation transrectal HIFU device (Sonablate-500 TM). Transrectal ultrasound images of the prostate and prostatic urethra were observed preoperatively and postoperatively. Serial study was performed 30 min, 30 days, 60 days and 180 days after the therapy. The rectum, periprostatic tissues, and prostate were excised en bloc and the tissues were fixed for gross and histological analysis. Our results showed that the average maximal diameter of prostatic urethra was 0.59±0.11 cm before the operation and 2.57±0.98 cm 60 days after the operation. The volume of prostate was 6.5±3.12 cm3 before the treatment while the volume was 4.13±0.23 cm3 60 days after the treatment and the differences were statistically significant (P<0.05).Histologically, there was a clear demarcation between the necrotic area of the treated tissues and the unaffected surrounding tissues. All the necrotic tissues in the targeted zone broke off and the prostatic urethra became cavitary 60 days later. The more frequent complications were urinary retention and frequency and hematuria. No rectal injury occurred during the treatment. It is concluded that the third-generation transrectal HIFU is capable of destroying prostatic tissue, substantially increasing the width of the prostatic urethra without causing injury to the adjacent tissues. The risk of postoperative complications associated with HIFU was low. HIFU may become a safe, effective and minimally invasive alternative for the treatment of prostatic diseases..

  3. F 2 excimer laser (157 nm) radiation modification and surface ablation of PHEMA hydrogels and the effects on bioactivity: Surface attachment and proliferation of human corneal epithelial cells

    Science.gov (United States)

    Zainuddin; Chirila, Traian V.; Barnard, Zeke; Watson, Gregory S.; Toh, Chiong; Blakey, Idriss; Whittaker, Andrew K.; Hill, David J. T.

    2011-02-01

    Physical and chemical changes at the surface of poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels modified by ablation with an F 2 excimer laser were investigated experimentally. An important observation was that only the outer exposed surface layers of the hydrogel were affected by the exposure to 157 nm radiation. The effect of the surface changes on the tendency of cells to adhere to the PHEMA was also investigated. A 0.5 cm 2 area of the hydrogel surfaces was exposed to laser irradiation at 157 nm to fluences of 0.8 and 4 J cm -2. The changes in surface topography were analysed by light microscopy and atomic force microscopy, while the surface chemistry was characterized by attenuated total reflection infrared and X-ray photoelectron spectroscopies. Cell-interfacial interactions were examined based on the proliferation of human corneal limbal epithelial (HLE) cells cultured on the laser-modified hydrogels, and on the unexposed hydrogels and tissue culture plastic for comparison. It was observed that the surface topography of laser-exposed hydrogels showed rippled patterns with a surface roughness increasing at the higher exposure dose. The changes in surface chemistry were affected not only by an indirect effect of hydrogen and hydroxyl radicals, formed by water photolysis, on the PHEMA, but also by the direct action of laser radiation on PHEMA if the surface layers of the gel become depleted of water. The laser treatment led to a change in the surface characteristics, with a lower concentration of ester side-chains and the formation of new oxygenated species at the surface. The surface also became more hydrophobic. Most importantly, the surface chemistry and the newly created surface topographical features were able to improve the attachment, spreading and growth of HLE cells.

  4. Thermochemical Ablation Therapy of VX2 Tumor Using a Permeable Oil-Packed Liquid Alkali Metal

    OpenAIRE

    2015-01-01

    Objective Alkali metal appears to be a promising tool in thermochemical ablation, but, it requires additional data on safety is required. The objective of this study was to explore the effectiveness of permeable oil-packed liquid alkali metal in the thermochemical ablation of tumors. Methods Permeable oil-packed sodium–potassium (NaK) was prepared using ultrasonic mixing of different ratios of metal to oil. The thermal effect of the mixture during ablation of muscle tissue ex vivo was evaluat...

  5. Corneal surface morphology following excimer laser ablation with humidified gases.

    Science.gov (United States)

    Krueger, R R; Campos, M; Wang, X W; Lee, M; McDonnell, P J

    1993-08-01

    To compare the effects of blowing dry (nitrogen or helium) and humidified gases over the corneal surface during photorefractive keratectomy. Excimer laser myopic ablations were performed on porcine eyes (10 per group) using humidified and dry nitrogen and helium gas under ambient conditions. Surface smoothness was quantified with light and electron microscopy. Corneas that were ablated using humidified gas were smooth and equivalent to those ablated under ambient conditions. Dry nitrogen and helium blowing resulted in increased surface irregularity evident on light and electron microscopy (P excimer laser corneal ablation produces a smoother surface than does the blowing of dry gas and is comparable to that produced under ambient (no blowing) conditions. Maintaining corneal moisture is important in photorefractive keratectomy. If blowing gas is necessary to remove debris from the surface, the gas should be humidified.

  6. DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine.

    Science.gov (United States)

    Cheng, Hai-Ying M; Laviolette, Steven R; van der Kooy, Derek; Penninger, Josef M

    2004-06-01

    DREAM (downstream regulatory element antagonistic modulator) is a novel transcriptional repressor for the prodynorphin gene, and genetic deletion of DREAM in mice results in a phenotype of ongoing analgesia by virtue of its effect on opioid gene expression. In the present study, we evaluated the motivational effects of opioids (morphine), cannabinoids [Delta(9)-tetrahydrocannabinol (THC)] and cocaine in mice lacking the dream gene (dream(-/-)). The aversive effects of THC were potentiated in dream(-/-) mice in a kappa-opioid receptor-dependent fashion, whereas morphine reward and the aversive effects of morphine withdrawal remained intact. The rewarding and aversive effects of cocaine were likewise unperturbed in dream(-/-) mice. Moreover, the aversive properties of lithium chloride and naloxone were unaffected by the absence of DREAM, indicating that the effect of DREAM on THC-induced dysphoria is not due to a general involvement in the behavioral response to aversive stimuli. Additionally, physical dependence to morphine and the locomotor-sensitizing effects of cocaine were unaltered in these animals. Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice.

  7. [Characterization of matrix effects in microanalysis of sulfide minerals by laser ablation-inductively coupled plasma-mass spectrometry based on an element pair method].

    Science.gov (United States)

    Yuan, Ji-hai; Zhan, Xiu-chun; Hu, Ming-yue; Zhao, Ling-hao; Sun, Dong-yang

    2015-02-01

    Matrix effect between reference materials and samples is one of the major factors affecting the accuracy of analytical results by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). However, there is no method or calculation formula to quantify matrix effect between standards and samples up to date. In this paper, the linear correlation coefficient r of the Ii/I(is-Ci)/Cis graphs of element pairs were used to characterize the matrix effect, which took the ratios of concentrations (ci/ c(is)) and intensities (Ii/Iis) of the analytical element and internal standard element as x-axis and gamma-axis, respectively. Matrix effects of 6 element pairs in 13 glass reference materials, 2 sulfide reference materials and 2 sulfide minerals using Fe as internal standard was studied, with the linear correlation coefficient r of Fe-Cu, Fe-Zn element pairs both less than 0. 999 and trace Fe--Mn, Fe--Co, Fe--Ga, Fe--Pb element pairs all better than 0.999. Matrix effects of 3 major element pairs in 2 sulfide ref- erence materials and 6 sulfide minerals using S as internal standard was also studied, with the linear correlation coefficient r of S--Fe, S--Cu, S--Zn all less than 0.999. The great majority of relative errors of EMPA analytical results for major elements in sulfide minerals were greater than 10%, whether analyzed using Fe as internal standard with glass reference materials as external standard, or S as internal standard with sulfide reference materials MASS-1, IMER-1 as external standard, respectively. But the most analytical results for trace elements calibrated by glass reference materials using Fe as internal standard were well agreed with sulfide standard MASS-1, with the relative errors less than 15%. The results showed that matrix effects existed in glass reference materials, sulfide reference materials and sulfide minerals, and it also proved a certain rationality and practicability for quantification of matrix effect using the linear

  8. Magnetic and robotic navigation for catheter ablation: "joystick ablation".

    Science.gov (United States)

    Ernst, Sabine

    2008-10-01

    Catheter ablation has become the treatment of choice to cure various arrhythmias in the last decades. The newest advancement of this general concept is made on the navigation ability using remote-controlled ablation catheters. This review summarizes the concept of the two currently available systems, followed by a critical review of the published clinical reports for each system, respectively. Despite the limited amount of data, an attempt to compare the two systems is made.

  9. Percutaneous thermal ablation for nodular thyroid diseases: an assessment of short-term effects%甲状腺结节性病变经皮热消融治疗的近期疗效评价

    Institute of Scientific and Technical Information of China (English)

    王淑荣; 章建全; 徐庆玲; 于守君; 张永林; 王锡菊; 孙艳华

    2011-01-01

    目的 探讨超声引导与监测下经皮穿刺微波、射频消融治疗甲状腺结节性病变的近期临床效果.方法 采用南京康友Thy-ablation型冷循环微波针及德国Celon-ProBreath单针双极式射频电极针在超声引导下经皮穿刺消融治疗甲状腺结节性病变104例(共289枚结节),观察治疗后的近期效果和不良反应及其并发症.结果 289枚结节均达到完全灭活,部分结节消融后获得了病理诊断结果,光镜下显示消融区为无滤泡结构的坏死物质;消融后第3~6个月随访观察发现结节缩小率达100%,无一例发生严重并发症,仅1枚结节需要二次消融.结论 超声引导下微波、射频原位消融治疗甲状腺结节性病变效果确切,创伤微小,操作简便,恢复迅速,可于门诊实施,值得临床推广.%Objective To investigate the short-term effects of ultrasound-guided percutaneous microwave ablation (MWA) and radiofrequency ablation (RFA) for treatment of thyroid nodules. Methods Totally 104 patients with 289 thyroid nodules underwent ultrasound-guided internal-cooled MWA and bipolar RFA in our department from July 2009 to January 2011. The outcomes of patients were closely assessed for a short-term of 6 months; the thermal ablation-related side-effects and complications were also discussed. Results Focal ultrasound images of the 289 thyroid nodules and the core-biopsy pathology findings of some nodules revealed complete coagulative degeneration of the ablated lesions. Follow-up for 3-6 months showed that sizes of all the nodules decreased to different extents. Only one nodule needed an extra ablation. No severe complications were observed. Conclusion The ultrasound-guided percutaneous MWA and RFA are effective, minimally invasive, easy to perform and can achieve rapid recovery. The methods can be used for out-patients with nodular thyroid diseases.

  10. Radiofrequency Ablation Treatment for Renal Cell Carcinoma: Early Clinical Experience

    Energy Technology Data Exchange (ETDEWEB)

    Park, Seong Hoon; Yoon, Seong Kuk; Cho, Jin Han; Oh, Jong Young; Nam, Kyung Jin; Kwon, Hee Jin; Kim, Su Yeon; Kang, Myong Jin; Choi, Sun Seob; Sung, Gyung Tak [Dong-A University College of Medicine, Busan (Korea, Republic of)

    2008-08-15

    To evaluate the early clinical experience associated with radiofrequency (RF) ablation in patients with renal cell carcinoma (RCC). The RF ablation treatment was performed on 17 tumors from 16 patients (mean age, 60.5 years; range, 43 73 years) with RCC. The treatment indications were localized, solid renal mass, comorbidities, high operation risk, and refusal to perform surgery. All tumors were treated by a percutaneous CT (n = 10), followed by an US-guided (n = 2), laparoscopy-assisted US (n = 2), and an open (n = 2) RF ablation. Furthermore, patients underwent a follow- up CT at one day, one week, one month, three and six months, and then every six months from the onset of treatment. We evaluated the technical success, technical effectiveness, ablation zone, benign periablation enhancement, irregular peripheral enhancement, and complications. All 17 exophytic tumors (mean size, 2.2 cm; range, 1.1 5.0 cm) were completely ablated. Technical success and effectiveness was achieved in all cases and the mean follow-up period was 23.8 months (range, 17 33 months). A local recurrence was not detected in any of the cases; however, five patients developed complications as a result of treatment, including hematuria (n = 2), mild thermal injury of the psoas muscle (n = 1), mild hydronephrosis (n = 1), and fistula formation (n = 1). The RF ablation is an alternative treatment for exophytic RCCs and represents a promising treatment for some patients with small RCCs.

  11. GMA-laser Hybrid Welding of High-strength Fine-grain Structural Steel with an Inductive Preheating

    Science.gov (United States)

    Lahdo, Rabi; Seffer, Oliver; Springer, André; Kaierle, Stefan; Overmeyer, Ludger

    The industrial useof GMA-laser hybrid welding has increased in the last 10 years, due to the brilliant quality of the laser beam radiation, and higher laser output powers. GMA-laser hybrid welding processes operate in a common molten pool. The combination of the laser beam and the arc results in improved welding speed, penetration depth, heat affected zone and gap bridgeability. Single-layer, GMA-laser hybrid welding processes have been developed for high-strength fine-grain structural steels with a grade of S690QL and a thickness of 15 mm and 20 mm. In addition, the welding process is assisted by an integrated, inductive preheating process to improve the mechanical properties of the welding seam. By using the determined parameters regarding the energy per unit length, and the preheating temperature, welding seams with high quality can be achieved.

  12. Application of a Device for Uniform Web Drying and Preheating Using Microwave Energy

    Energy Technology Data Exchange (ETDEWEB)

    Frederick W. Ahrens; C. Habeger; J. Loughran; T. Patterson

    2003-10-02

    The project summarized in this report dealt with an evaluation of new microwave applicator ideas for paper preheating and drying. The technical basis for success in this project is the fact that Industrial Microwave Systems has recently identified certain previously unrecognized wave guide ''design variables'' and hardware implementation concepts that can be employed to greatly improve the uniformity of microwave energy distribution for continuous flow processes. Two applicator concepts were ultimately evaluated, a Cross-Machine Direction (CD) oriented applicator and a Machine Direction (MD) oriented applicator. The economic basis for success is the result of several factors. Since 1985, the capital expenditure required for an industrial microwave applicator system has decreased by a factor of four. The maintenance costs have decreased by a factor of 10 and the life expectancy of the magnetron has increased by more than a factor of four to in excess of 8,000 hours (nearly one year at 24 hours/day operation).

  13. FAILURE ANALYSIS IN TUBING OF AIR PREHEATER OF BOILER FROM A SUGARCANE MILL

    Directory of Open Access Journals (Sweden)

    Joner Oliveira Alves

    2014-10-01

    Full Text Available The increased demand for energy from sugarcane bagasse has made the sugar and alcohol mills search alternatives to reduce maintenance of the boilers, releasing more time to the production. The stainless steel use has become one of the main tools for such reduction. However, specification errors can lead to premature failures. This work reports the factors that led tubes of AISI 409 stainless steel fail after half season when applied in a air preheater of boiler from a sugarcane mill. In such application, the AISI 304 lasts about 15 seasons and the carbon steel about 3. A tube sent by the sugar mill was characterized by wet chemical analysis, optical microscopy and EDS. Results indicated chloride formation on the internal walls of the tube, which combined with the environment, accelerated the corrosion process. The carbon steel showed high lifetime due to a 70% higher thickness. Due to the work condictions is recommended the use of stainless steels with higher corrosion resistance, such as the traditional AISI 304 or the ferritic AISI 444, the last presents better thermal exchange.

  14. Field enhancement induced laser ablation

    DEFF Research Database (Denmark)

    Fiutowski, Jacek; Maibohm, Christian; Kjelstrup-Hansen, Jakob

    Sub-diffraction spatially resolved, quantitative mapping of strongly localized field intensity enhancement on gold nanostructures via laser ablation of polymer thin films is reported. Illumination using a femtosecond laser scanning microscope excites surface plasmons in the nanostructures...

  15. Laser ablation cell sorting in scanning cytometry

    Science.gov (United States)

    Shen, Feimo; Price, Jeffrey H.

    2001-05-01

    Flow cytometry has been an important tool for automated cells sorting. However, the lack of good sensitivity prevents it from being used for rare events sorting; furthermore, fragile cells, anchorage-dependent cells, and clump forming cells cannot be sorted this way. A fully automated, high-speed scanning cytometer with autofocus and image segmentation is capable of accurately locating contaminant cells in a monolayer cell population. A laser ablation system was incorporated into the cytometer to negatively sort out the unwanted cells by applying a focused, ultra-short laser pulse (sub-micron diameter, pulse duration = 4 nsec, wavelength - 500 nm) to each targeted cell. Due to the high power density (approximately 1010 W/cm2) that was present at the focal point, disruptive mechanical forces were generated and were responsible for the kill. Fluorescently stained NIH-3T3 fibroblast cells were used as a model contaminant target ells in an unstained NIH-3T3 population to determine the identification-kill effectiveness. The contaminant cells were stained with the fluorochrome CellTracker Blue CMAC, whereas the background cells were left intact. Ablation pulses were applied in frame-by-frame increment batches to the cell culture on the microscope. The negative sorting effectiveness was analyzed by automatically re-scanning the post-ablation cell culture in phase contrast and propidium iodide stained epi fluorescent fields to verify cell death.

  16. Ablative Approaches for Pulmonary Metastases.

    Science.gov (United States)

    Boyer, Matthew J; Ricardi, Umberto; Ball, David; Salama, Joseph K

    2016-02-01

    Pulmonary metastases are common in patients with cancer for which surgery is considered a standard approach in appropriately selected patients. A number of patients are not candidates for surgery due to a medical comorbidities or the extent of surgery required. For these patients, noninvasive or minimally invasive approaches to ablate pulmonary metastases are potential treatment strategies. This article summarizes the rationale and outcomes for non-surgical treatment approaches, including radiotherapy, radiofrequency and microwave ablation, for pulmonary metastases.

  17. Radiofrequency Ablation in Barrett's Esophagus

    Directory of Open Access Journals (Sweden)

    Vani J.A. Konda

    2014-01-01

    Full Text Available Radiofrequency ablation (RFA is an endoscopic modality used in the treatment of Barrett's esophagus. RFA may be performed using a balloon-based catheter or using one of the probe catheters that attaches to the distal end of the endoscope. Here we demonstrate step-by-step instruction in using radiofrequency ablation in the treatment of Barrett's esophagus and highlight key concepts in the technique.

  18. Selective ablation of rabbit atherosclerotic plaque with less thermal effect by the control of pulse structure of a quantum cascade laser in the 5.7 μm wavelength range

    Science.gov (United States)

    Hashimura, Keisuke; Ishii, Katsunori; Awazu, Kunio

    2016-03-01

    Cholesteryl esters are main components of atherosclerotic plaques and have an absorption peak at the wavelength of 5.75 μm originated from C=O stretching vibration mode of ester bond. Our group achieved the selective ablation of atherosclerotic lesions using a quantum cascade laser (QCL) in the 5.7 μm wavelength range. QCLs are relatively new types of semiconductor lasers that can emit mid-infrared range. They are sufficiently compact and considered to be useful for clinical application. However, large thermal effects were observed because the QCL worked as quasicontinuous wave (CW) lasers due to its short pulse interval. Then we tried macro pulse irradiation (irradiation of pulses at intervals) of the QCL and achieved effective ablation with less-thermal effects than conventional quasi-CW irradiation. However, lesion selectivity might be changed by changing pulse structure. Therefore, in this study, irradiation effects of the macro pulse irradiation to rabbit atherosclerotic plaque and normal vessel were compared. The macro pulse width and the macro pulse interval were set to 0.5 and 12 ms, respectively, because the thermal relaxation time of rabbit normal and atherosclerotic aortas in the oscillation wavelength of the QCL was 0.5-12 ms. As a result, cutting difference was achieved between rabbit atherosclerotic and normal aortas by the macro pulse irradiation. Therefore, macro pulse irradiation of a QCL in the 5.7 μm wavelength range is effective for reducing thermal effects and selective ablation of the atherosclerotic plaque. QCLs have the potential of realizing less-invasive laser angioplasty.

  19. Formation of the preheated zone ahead of a propagating flame and the mechanism underlying the deflagration-to-detonation transition

    Science.gov (United States)

    Liberman, M. A.; Kuznetsov, M.; Ivanov, A.; Matsukov, I.

    2009-01-01

    The Letter presents analytical, numerical and experimental studies of the mechanism underlying the deflagration-to-detonation transition (DDT). Insight into how, when, and where DDT occurs is obtained by analyzing analytically and by means of multidimensional numerical simulations dynamics of a flame accelerating in a tube with no-slip walls. It is shown that the deflagration-to-detonation transition exhibits three separate stages of evolution corroborating majority experimental observations. During the first stage flame accelerates and generates shocks far ahead of the flame front. During the second stage the flame slows down, shocks are formed in the immediate proximity of the flame front and the preheated zone ahead of the flame front is created. The third stage is self-restructuring of the steep temperature profile within the flame, formation of a reactivity gradient and the actual formation of the detonation wave itself. The mechanism for the detonation wave formation, given an appropriate formation of the preheated zone, seems to be universal and involves a reactivity gradient formed from the initially steep flame temperature profile in the presence of the preheated zone. The developed theory and numerical simulations are found to be well consistent with extensive experiments of the DDT in hydrogen-oxygen and ethylene-oxygen mixtures in tubes with smooth and rough walls.

  20. A Rare Complication of Radiofrequency Tonsil Ablation: Horner Syndrome

    Directory of Open Access Journals (Sweden)

    Cuneyt Kucur

    2015-01-01

    Full Text Available Chronic tonsillitis is a common disease, and several different surgical techniques are used to treat this condition. In recent years, techniques such as radiofrequency ablation and coblation have been commonly used for tonsil surgery. In this report, we present the cases of two pediatric patients who developed ptosis, miosis, and enophthalmos (Horner syndrome after radiofrequency ablation for tonsil reduction and discuss the technique of radiofrequency ablation of the tonsils. In the early postoperative period, miosis and ptosis were observed on the right side in one patient and on the left side in the other patient. Both patients were treated with 1 mg/kg/day methylprednisolone, which were tapered by halving the dose every 3 days. Miosis and ptosis improved after treatment in both patients. Along with the case presentation, we discuss the effectiveness and complications of radiofrequency ablation of the tonsils. These unusual complications of tonsil ablation may help ENT physicians who do not yet have a preferred surgical technique for tonsillectomy to make an informed decision. Limited data are available about the possible complications of radiofrequency ablation of the tonsils. The present report contributes to the literature on this topic.

  1. A Rare Complication of Radiofrequency Tonsil Ablation: Horner Syndrome.

    Science.gov (United States)

    Kucur, Cuneyt; Ozbay, Isa; Oghan, Fatih; Yildirim, Nadir; Zeybek Sivas, Zuhal; Canbaz Kabay, Sibel

    2015-01-01

    Chronic tonsillitis is a common disease, and several different surgical techniques are used to treat this condition. In recent years, techniques such as radiofrequency ablation and coblation have been commonly used for tonsil surgery. In this report, we present the cases of two pediatric patients who developed ptosis, miosis, and enophthalmos (Horner syndrome) after radiofrequency ablation for tonsil reduction and discuss the technique of radiofrequency ablation of the tonsils. In the early postoperative period, miosis and ptosis were observed on the right side in one patient and on the left side in the other patient. Both patients were treated with 1 mg/kg/day methylprednisolone, which were tapered by halving the dose every 3 days. Miosis and ptosis improved after treatment in both patients. Along with the case presentation, we discuss the effectiveness and complications of radiofrequency ablation of the tonsils. These unusual complications of tonsil ablation may help ENT physicians who do not yet have a preferred surgical technique for tonsillectomy to make an informed decision. Limited data are available about the possible complications of radiofrequency ablation of the tonsils. The present report contributes to the literature on this topic.

  2. A Rare Complication of Radiofrequency Tonsil Ablation: Horner Syndrome

    Science.gov (United States)

    Ozbay, Isa; Yildirim, Nadir; Zeybek Sivas, Zuhal; Canbaz Kabay, Sibel

    2015-01-01

    Chronic tonsillitis is a common disease, and several different surgical techniques are used to treat this condition. In recent years, techniques such as radiofrequency ablation and coblation have been commonly used for tonsil surgery. In this report, we present the cases of two pediatric patients who developed ptosis, miosis, and enophthalmos (Horner syndrome) after radiofrequency ablation for tonsil reduction and discuss the technique of radiofrequency ablation of the tonsils. In the early postoperative period, miosis and ptosis were observed on the right side in one patient and on the left side in the other patient. Both patients were treated with 1 mg/kg/day methylprednisolone, which were tapered by halving the dose every 3 days. Miosis and ptosis improved after treatment in both patients. Along with the case presentation, we discuss the effectiveness and complications of radiofrequency ablation of the tonsils. These unusual complications of tonsil ablation may help ENT physicians who do not yet have a preferred surgical technique for tonsillectomy to make an informed decision. Limited data are available about the possible complications of radiofrequency ablation of the tonsils. The present report contributes to the literature on this topic. PMID:26064747

  3. Effects of laser energy and impact surface on the stopping distance in metal oxide targets laser ablation

    Science.gov (United States)

    Lagrange, J.-F.; Wolfman, J.; Motret, O.

    2012-03-01

    The aim of this paper is to study the effect of fluence on the propagating parameters of the plasma plume. Two complex metal oxide targets CaCu3Ti4O12 and Ba0.6Sr0.4TiO3 were studied at moderate fluences (1.1 to 2.5 J.cm-2) and at two oxygen pressures (10 and 30 Pa). From imaging data, we showed that the stopping distance is drastically modified whether the fluence is increased by raising laser energy or by reducing impact surface. Indeed, in the first case the stopping distance was increased, while in the second case the stopping distance was almost not influenced.

  4. Curative effects of two new endometrial ablation procedures using radiofrequency thermocoagulation for the treatment of severe abnormal uterine bleeding.

    Science.gov (United States)

    Yin, Geping; Li, Juan; Zhu, Tongyu; Chen, Ming

    2013-07-01

    Severe Abnormal Uterine Bleeding (SAUB) is a common gynecological disorder. The clinical characteristics include disordered menstrual cycle and massive bleeding that can cause anemia or secondary infection. Current treatment mainly relies on drug therapy or surgical removal of the uterus, each having its significant disadvantages. How to preserve the uterus, reduce the pain from surgery, and achieve better treatment effects have been well known but remaining as unresolved issues. This study aims at evaluating two types of radiofrequency (RF) thermocoagulation procedures for the treatment of SAUB: the RF-A procedure group included 25 SAUB patients ≥45 years of age treated for amenorrhea; the RF-B procedure group included 51 patients at bleeding. Post-treatment ratings of menstrual satisfaction and pre-/post-treatment menstrual scores-pictorial blood loss assessment chart (PBAC)-and hemoglobin levels were collected; and the mean length of follow-up was 72 months. Also, 38 SAUB patients treated with standard drug regimens served as a control group. The results of the study showed that following RF treatment, the average long-term patient menstrual satisfaction was greater than 92 %. In both the RF groups, PBAC scores and hemoglobin levels were significantly improved from baseline (p < .05). Compared with the control group, PBAC scores and hemoglobin levels were also significantly better for the RF groups at 6-24-month post-operation. Patients experienced no hysterectomy in association with the RF procedures. In conclusion, this pilot study suggests that the novel RF procedures are both safe and effective in treating patients with SAUB. Further investigation is necessary to evaluate their application in broader clinical indication.

  5. Short-term effects and adverse events of endoscopically applied radiofrequency ablation appear to be comparable with photodynamic therapy in hilar cholangiocarcinoma

    Science.gov (United States)

    Schmidt, A; Bloechinger, M; Weber, A; Siveke, J; von Delius, S; Prinz, C; Schmitt, W; Schmid, RM

    2016-01-01

    Background and study aims Radiofrequency ablation (RFA) is a new endoscopic palliation therapy for malignant biliary obstruction. The aim of this study was to compare the short-term effects of biliary drainage and adverse events of this technique with the standard of endoscopical treatment of hilar cholangiocarcinoma, photodynamic therapy (PDT). Patients and methods We retrospectively and since December 2012 prospectively investigated the efficacy and adverse events of RFA in patients with hilar cholangiocarcinoma in two tertiary referral centers between November 2011 and January 2013. The approach of the study was prospective, but because of the large amount of retrospectively included patients, the design of the study is overall retrospective. A group of 20 patients treated with PDT between April 2005 and May 2011 served as a historical control. Results Fourteen patients received 31 biliary RFAs and 20 patients received 36 PDTs. Within the RFA group, a significant decrease (p = 0.046) of the bilirubin level was seen 14 days after the first RFA (3.3 ± 3.9 (mg/dl) versus 2.3 ± 2.6 (mg/dl)). In the PDT group no significant decrease (p = 0.67) of the bilirubin level was obtained (4.1 ± 6.9 (mg/dl) versus 3.5 ± 5.3 (mg/dl)). In the PDT group (13/20, 65%) a significantly higher number of premature stent replacemen