WorldWideScience

Sample records for precision multi-epoch astrometry

  1. High-precision astrometry towards ELTs

    NARCIS (Netherlands)

    Massari, Davide; Fiorentino, Giuliana; Tolstoy, Eline; McConnachie, Alan; Stuik, Remko; Schreiber, Laura; Andersen, David; Clénet, Yann; Davies, Richard; Gratadour, Damien; Kuijken, Konrad; Navarro, Ramon; Pott, Jörg-Uwe; Rodeghiero, Gabriele; Turri, Paolo; Verdoes Kleijn, Gijs

    2016-01-01

    With the aim of paving the road for future accurate astrometry with MICADO at the European-ELT, we performed an astrometric study using two different but complementary approaches to investigate two critical components that contribute to the total astrometric accuracy. First, we tested the predicted

  2. Observing exoplanet populations with high-precision astrometry

    Science.gov (United States)

    Sahlmann, Johannes

    2012-06-01

    This thesis deals with the application of the astrometry technique, consisting in measuring the position of a star in the plane of the sky, for the discovery and characterisation of extra-solar planets. It is feasible only with a very high measurement precision, which motivates the use of space observatories, the development of new ground-based astronomical instrumentation and of innovative data analysis methods: The study of Sun-like stars with substellar companions using CORALIE radial velocities and HIPPARCOS astrometry leads to the determination of the frequency of close brown dwarf companions and to the discovery of a dividing line between massive planets and brown dwarf companions; An observation campaign employing optical imaging with a very large telescope demonstrates sufficient astrometric precision to detect planets around ultra-cool dwarf stars and the first results of the survey are presented; Finally, the design and initial astrometric performance of PRIMA, ! a new dual-feed near-infrared interferometric observing facility for relative astrometry is presented.

  3. Precision Photometry and Astrometry from Pan-STARRS

    Science.gov (United States)

    Magnier, Eugene A.; Pan-STARRS Team

    2018-01-01

    The Pan-STARRS 3pi Survey has been calibrated with excellent precision for both astrometry and photometry. The Pan-STARRS Data Release 1, opened to the public on 2016 Dec 16, provides photometry in 5 well-calibrated, well-defined bandpasses (grizy) astrometrically registered to the Gaia frame. Comparisons with other surveys illustrate the high quality of the calibration and provide tests of remaining systematic errors in both Pan-STARRS and those external surveys. With photometry and astrometry of roughly 3 billion astronomical objects, the Pan-STARRS DR1 has substantial overlap with Gaia, SDSS, 2MASS and other surveys. I will discuss the astrometric tie between Pan-STARRS DR1 and Gaia and show comparisons between Pan-STARRS and other large-scale surveys.

  4. Radio emission from Supernovae and High Precision Astrometry

    Science.gov (United States)

    Perez-Torres, M. A.

    1999-11-01

    The present thesis work makes contributions in two scientific fronts: differential astrometry over the largest angular scales ever attempted (approx. 15 arcdegrees) and numerical simulations of radio emission from very young supernovae. In the first part, we describe the results of the use of very-long-baseline interferometry (VLBI) in one experiment designed to measure with very high precision the angular distance between the radio sources 1150+812 (QSO) and 1803+784 (BL Lac). We observed the radio sources on 19 November 1993 using an intercontinental array of radio telescopes, which simultaneously recorded at 2.3 and 8.4 GHz. VLBI differential astrometry is capable, Nature allowing, of yielding source positions with precisions well below the milliarcsecond level. To achieve this precision, we first had to accurately model the rotation of the interferometric fringes via the most precise models of Earth Orientation Parameters (EOP; precession, polar motion and UT1, nutation). With this model, we successfully connected our phase delay data at both frequencies and, using difference astrometric techniques, determined the coordinates of 1803+784 relative to those of 1150+812-within the IERS reference frame--with an standard error of about 0.6 mas in each coordinate. We then corrected for several effects including propagation medium (mainly the atmosphere and ionosphere), and opacity and source-structure effects within the radio sources. We stress that our dual-frequency measurements allowed us to accurately subtract the ionosphere contribution from our data. We also used GPS-based TEC measurements to independently find the ionosphere contribution, and showed that these contributions agree with our dual-frequency measurements within about 2 standard deviations in the less favorables cases (the longest baselines), but are usually well within one standard deviation. Our estimates of the relative positions, whether using dual-frequency-based or GPS-based ionosphere

  5. The Dynamics of the Local Group in the Era of Precision Astrometry

    Science.gov (United States)

    Besla, Gurtina; Garavito-Camargo, Nicolas; Patel, Ekta

    2018-06-01

    Our understanding of the dynamics of our Local Group of galaxies has changed dramatically over the past few years owing to significant advancements in astrometry and our theoretical understanding of galaxy structure. New surveys now enable us to map the 3D structure of our Milky Way and the dynamics of tracers of its dark matter distribution, like globular clusters, satellite galaxies and streams, with unprecedented precision. Some results have met with controversy, challenging preconceived notions of the orbital dynamics of key components of the Local Group. I will provide an overview of this evolving picture of our Local Group and outline how we can test the cold dark matter paradigm in the era of Gaia, LSST and JWST.

  6. An engineered design of a diffractive mask for high precision astrometry

    Science.gov (United States)

    Dennison, Kaitlin; Ammons, S. Mark; Garrel, Vincent; Marin, Eduardo; Sivo, Gaetano; Bendek, Eduardo; Guyon, Oliver

    2016-07-01

    AutoCAD, Zemax Optic Studio 15, and Interactive Data Language (IDL) with the Proper Library are used to computationally model and test a diffractive mask (DiM) suitable for use in the Gemini Multi-Conjugate Adaptive Optics System (GeMS) on the Gemini South Telescope. Systematic errors in telescope imagery are produced when the light travels through the adaptive optics system of the telescope. DiM is a transparent, flat optic with a pattern of miniscule dots lithographically applied to it. It is added ahead of the adaptive optics system in the telescope in order to produce diffraction spots that will encode systematic errors in the optics after it. Once these errors are encoded, they can be corrected for. DiM will allow for more accurate measurements in astrometry and thus improve exoplanet detection. The mechanics and physical attributes of the DiM are modeled in AutoCAD. Zemax models the ray propagation of point sources of light through the telescope. IDL and Proper simulate the wavefront and image results of the telescope. Aberrations are added to the Zemax and IDL models to test how the diffraction spots from the DiM change in the final images. Based on the Zemax and IDL results, the diffraction spots are able to encode the systematic aberrations.

  7. HIGH-PRECISION RADIO AND INFRARED ASTROMETRY OF LSPM J1314+1320AB. I. PARALLAX, PROPER MOTIONS, AND LIMITS ON PLANETS

    Energy Technology Data Exchange (ETDEWEB)

    Forbrich, Jan [University of Vienna, Department of Astrophysics, Türkenschanzstr. 17, A-1180 Vienna (Austria); Dupuy, Trent J.; Rizzuto, Aaron; Mann, Andrew W.; Kraus, Adam L. [The University of Texas at Austin, Department of Astronomy, 2515 Speedway C1400, Austin, TX 78712 (United States); Reid, Mark J.; Berger, Edo [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Liu, Michael C.; Aller, Kimberly [Institute for Astronomy, University of Hawai’i, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2016-08-10

    We present multi-epoch astrometric radio observations with the Very Long Baseline Array (VLBA) of the young ultracool-dwarf binary LSPM J1314+1320AB. The radio emission comes from the secondary star. Combining the VLBA data with Keck near-infrared adaptive-optics observations of both components, a full astrometric fit of parallax (π {sub abs} = 57.975 ± 0.045 mas, corresponding to a distance of d = 17.249 ± 0.013 pc), proper motion (μ {sub α} {sub cos} {sub δ} = −247.99 ± 0.10 mas yr{sup −1}, μ {sub δ} = −183.58 ± 0.22 mas yr{sup −1}), and orbital motion is obtained. Despite the fact that the two components have nearly identical masses to within ±2%, the secondary’s radio emission exceeds that of the primary by a factor of ≳30, suggesting a difference in stellar rotation history, which could result in different magnetic field configurations. Alternatively, the emission could be anisotropic and beamed toward us for the secondary but not for the primary. Using only reflex motion, we exclude planets of mass 0.7–10 M {sub jup} with orbital periods of 600–10 days, respectively. Additionally, we use the full orbital solution of the binary to derive an upper limit for the semimajor axis of 0.23 au for stable planetary orbits within this system. These limits cover a parameter space that is inaccessible with, and complementary to, near-infrared radial velocity surveys of ultracool dwarfs. Our absolute astrometry will constitute an important test for the astrometric calibration of Gaia .

  8. ARTIFICIAL INCOHERENT SPECKLES ENABLE PRECISION ASTROMETRY AND PHOTOMETRY IN HIGH-CONTRAST IMAGING

    Energy Technology Data Exchange (ETDEWEB)

    Jovanovic, N.; Guyon, O.; Pathak, P.; Kudo, T. [National Astronomical Observatory of Japan, Subaru Telescope, 650 North A’Ohoku Place, Hilo, HI, 96720 (United States); Martinache, F. [Observatoire de la Cote d’Azur, Boulevard de l’Observatoire, F-06304 Nice (France); Hagelberg, J., E-mail: jovanovic.nem@gmail.com [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States)

    2015-11-10

    State-of-the-art coronagraphs employed on extreme adaptive optics enabled instruments are constantly improving the contrast detection limit for companions at ever-closer separations from the host star. In order to constrain their properties and, ultimately, compositions, it is important to precisely determine orbital parameters and contrasts with respect to the stars they orbit. This can be difficult in the post-coronagraphic image plane, as by definition the central star has been occulted by the coronagraph. We demonstrate the flexibility of utilizing the deformable mirror in the adaptive optics system of the Subaru Coronagraphic Extreme Adaptive Optics system to generate a field of speckles for the purposes of calibration. Speckles can be placed up to 22.5 λ/D from the star, with any position angle, brightness, and abundance required. Most importantly, we show that a fast modulation of the added speckle phase, between 0 and π, during a long science integration renders these speckles effectively incoherent with the underlying halo. We quantitatively show for the first time that this incoherence, in turn, increases the robustness and stability of the adaptive speckles, which will improve the precision of astrometric and photometric calibration procedures. This technique will be valuable for high-contrast imaging observations with imagers and integral field spectrographs alike.

  9. Light propagation in the gravitational field of N arbitrarily moving bodies in the 1.5PN approximation for high-precision astrometry

    Science.gov (United States)

    Zschocke, Sven

    2016-05-01

    High-precision astrometry on sub-micro-arcsecond level in angular resolution requires accurate determination of the trajectory of a light-signal from the celestial light source through the gravitational field of the Solar System toward the observer. In this investigation the light trajectory in the gravitational field of N moving bodies is determined in the 1.5 post-Newtonian approximation. In the approach presented two specific issues of particular importance are accounted for: (1) According to the recommendations of International Astronomical Union, the metric of the Solar System is expressed in terms of intrinsic mass-multipoles and intrinsic spin-multipoles of the massive bodies, allowing for arbitrary shape, inner structure and rotational motion of the massive bodies of the Solar System. (2) The Solar System bodies move along arbitrary world lines which can later be specified by Solar System ephemeris. The presented analytical solution for light trajectory is a primary requirement for extremely high-precision astrometry on sub-micro-arcsecond level of accuracy and associated massive computations in astrometric data reduction. An estimation of the numerical magnitude for time delay and light deflection of the leading multipoles is given.

  10. THE MASS OF HD 38529c FROM HUBBLE SPACE TELESCOPE ASTROMETRY AND HIGH-PRECISION RADIAL VELOCITIES

    International Nuclear Information System (INIS)

    Benedict, G. Fritz; McArthur, Barbara E.; Bean, Jacob L.; Barnes, Rory; Harrison, Thomas E.; Hatzes, Artie; Martioli, Eder; Nelan, Edmund P.

    2010-01-01

    Hubble Space Telescope Fine Guidance Sensor astrometric observations of the G4 IV star HD 38529 are combined with the results of the analysis of extensive ground-based radial velocity (RV) data to determine the mass of the outermost of two previously known companions. Our new RVs obtained with the Hobby-Eberly Telescope and velocities from the Carnegie-California group now span over 11 yr. With these data we obtain improved RV orbital elements for both the inner companion, HD 38529b, and the outer companion, HD 38529c. We identify a rotational period of HD 38529 (P rot = 31.65 ± 0fd17) with Fine Guidance Sensor photometry. The inferred star spot fraction is consistent with the remaining scatter in velocities being caused by spot-related stellar activity. We then model the combined astrometric and RV measurements to obtain the parallax, proper motion, perturbation period, perturbation inclination, and perturbation size due to HD 38529c. For HD 38529c we find P = 2136.1 ± 0.3 d, perturbation semimajor axis α = 1.05 ± 0.06 mas, and inclination i = 48. 0 3 ± 3. 0 7. Assuming a primary mass M * = 1.48 M sun , we obtain a companion mass M c = 17.6 +1.5 -1.2 M Jup , 3σ above a 13 M Jup deuterium burning, brown dwarf lower limit. Dynamical simulations incorporating this accurate mass for HD 38529c indicate that a near-Saturn mass planet could exist between the two known companions. We find weak evidence of an additional low amplitude signal that can be modeled as a planetary-mass (∼0.17 M Jup ) companion at P ∼194 days. Including this component in our modeling lowers the error of the mass determined for HD 38529c. Additional observations (RVs and/or Gaia astrometry) are required to validate an interpretation of HD 38529d as a planetary-mass companion. If confirmed, the resulting HD 38529 planetary system may be an example of a 'Packed Planetary System'.

  11. The Mass of the Candidate Exoplanet Companion to HD 33636 from Hubble Space Telescope Astrometry and High-Precision Radial Velocities

    Science.gov (United States)

    Bean, Jacob L.; McArthur, Barbara E.; Benedict, G. Fritz; Harrison, Thomas E.; Bizyaev, Dmitry; Nelan, Edmund; Smith, Verne V.

    2007-08-01

    We have determined a dynamical mass for the companion to HD 33636 that indicates it is a low-mass star instead of an exoplanet. Our result is based on an analysis of Hubble Space Telescope (HST) astrometry and ground-based radial velocity data. We have obtained high-cadence radial velocity measurements spanning 1.3 yr of HD 33636 with the Hobby-Eberly Telescope at McDonald Observatory. We combined these data with previously published velocities to create a data set that spans 9 yr. We used this data set to search for, and place mass limits on, the existence of additional companions in the HD 33636 system. Our high-precision astrometric observations of the system with the HST Fine Guidance Sensor 1r span 1.2 yr. We simultaneously modeled the radial velocity and astrometry data to determine the parallax, proper motion, and perturbation orbit parameters of HD 33636. Our derived parallax, πabs=35.6+/-0.2 mas, agrees within the uncertainties with the Hipparcos value. We find a perturbation period P=2117.3+/-0.8 days, semimajor axis aA=14.2+/-0.2 mas, and system inclination i=4.1deg+/-0.1deg. Assuming the mass of the primary star to be MA=1.02+/-0.03 Msolar, we obtain a companion mass MB=142+/-11 MJup=0.14+/-0.01 Msolar. The much larger true mass of the companion relative to its minimum mass estimated from the spectroscopic orbit parameters (Msini=9.3 MJup) is due to the nearly face-on orbit orientation. This result demonstrates the value of follow-up astrometric observations to determine the true masses of exoplanet candidates detected with the radial velocity method. Based on data obtained with the NASA/ESA Hubble Space Telescope (HST) and the Hobby-Eberly Telescope (HET). The HST observations were obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. The HET is a joint project of the University of Texas at Austin, Pennsylvania State University, Stanford

  12. Orbits of massive satellite galaxies - II. Bayesian estimates of the Milky Way and Andromeda masses using high-precision astrometry and cosmological simulations

    Science.gov (United States)

    Patel, Ekta; Besla, Gurtina; Mandel, Kaisey

    2017-07-01

    In the era of high-precision astrometry, space observatories like the Hubble Space Telescope (HST) and Gaia are providing unprecedented 6D phase-space information of satellite galaxies. Such measurements can shed light on the structure and assembly history of the Local Group, but improved statistical methods are needed to use them efficiently. Here we illustrate such a method using analogues of the Local Group's two most massive satellite galaxies, the Large Magellanic Cloud (LMC) and Triangulum (M33), from the Illustris dark-matter-only cosmological simulation. We use a Bayesian inference scheme combining measurements of positions, velocities and specific orbital angular momenta (j) of the LMC/M33 with importance sampling of their simulated analogues to compute posterior estimates of the Milky Way (MW) and Andromeda's (M31) halo masses. We conclude that the resulting host halo mass is more susceptible to bias when using measurements of the current position and velocity of satellites, especially when satellites are at short-lived phases of their orbits (I.e. at pericentre). Instead, the j value of a satellite is well conserved over time and provides a more reliable constraint on host mass. The inferred virial mass of the MW (M31) using j of the LMC (M33) is {{M}}_{vir, MW} = 1.02^{+0.77}_{-0.55} × 10^{12} M⊙ ({{M}}_{vir, M31} = 1.37^{+1.39}_{-0.75} × 10^{12} M⊙). Choosing simulated analogues whose j values are consistent with the conventional picture of a previous (<3 Gyr ago), close encounter (<100 kpc) of M33 about M31 results in a very low virial mass for M31 (˜1012 M⊙). This supports the new scenario put forth in Patel, Besla & Sohn, wherein M33 is on its first passage about M31 or on a long-period orbit. We conclude that this Bayesian inference scheme, utilizing satellite j, is a promising method to reduce the current factor of 2 spread in the mass range of the MW and M31. This method is easily adaptable to include additional satellites as new 6D

  13. ARECIBO MULTI-EPOCH H I ABSORPTION MEASUREMENTS AGAINST PULSARS: TINY-SCALE ATOMIC STRUCTURE

    International Nuclear Information System (INIS)

    Stanimirovic, S.; Weisberg, J. M.; Pei, Z.; Tuttle, K.; Green, J. T.

    2010-01-01

    We present results from multi-epoch neutral hydrogen (H I) absorption observations of six bright pulsars with the Arecibo telescope. Moving through the interstellar medium (ISM) with transverse velocities of 10-150 AU yr -1 , these pulsars have swept across 1-200 AU over the course of our experiment, allowing us to probe the existence and properties of the tiny-scale atomic structure (TSAS) in the cold neutral medium (CNM). While most of the observed pulsars show no significant change in their H I absorption spectra, we have identified at least two clear TSAS-induced opacity variations in the direction of B1929+10. These observations require strong spatial inhomogeneities in either the TSAS clouds' physical properties themselves or else in the clouds' galactic distribution. While TSAS is occasionally detected on spatial scales down to 10 AU, it is too rare to be characterized by a spectrum of turbulent CNM fluctuations on scales of 10 1 -10 3 AU, as previously suggested by some work. In the direction of B1929+10, an apparent correlation between TSAS and interstellar clouds inside the warm Local Bubble (LB) indicates that TSAS may be tracing the fragmentation of the LB wall via hydrodynamic instabilities. While similar fragmentation events occur frequently throughout the ISM, the warm medium surrounding these cold cloudlets induces a natural selection effect wherein small TSAS clouds evaporate quickly and are rare, while large clouds survive longer and become a general property of the ISM.

  14. The Reel Deal: Interpreting HST Multi-Epoch Movies of YSO Jets.

    Science.gov (United States)

    Frank, Adam

    2010-09-01

    The goal of this proposal is to bring the theoretical interpretation of Young Stellar Object jets and their environments to a new level of realism. We propose to build on the results of a successful Cycle 16 observing proposal that has obtained 3rd epoch images of HH jets. We will use Adaptive Mesh Refinement MHD simulations {developed by our team} to carry forward a detailed program of modeling and interpretation of the time-dependent behavior revealed in the new, extended multi-epoch data set. Only with the third epoch observations can we explore forces: i.e. accelerations, decelerations and structural changes to develop an accurate understanding of physical processes occurring in hypersonic, magnetized jet flows. Our studies will allow us to characterize the jets and, therefore, make the crucial link with jet central engines. We note an innovative feature of our project is its link with laboratory astrophysical experiments of jets. Our analysis of the observations will be used to determine future laboratory experiments which will explore A?clumpyA? jet propagation issues.

  15. The Shock Dynamics of Heterogeneous YSO Jets: 3D Simulations Meet Multi-epoch Observations

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, E. C.; Frank, A. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627-0171 (United States); Hartigan, P. [Department of Physics and Astronomy, Rice University, 6100 S. Main, Houston, TX 77521-1892 (United States); Lebedev, S. V. [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom)

    2017-03-10

    High-resolution observations of young stellar object (YSO) jets show them to be composed of many small-scale knots or clumps. In this paper, we report results of 3D numerical simulations designed to study how such clumps interact and create morphologies and kinematic patterns seen in emission line observations. Our simulations focus on clump scale dynamics by imposing velocity differences between spherical, over-dense regions, which then lead to the formation of bow shocks as faster clumps overtake slower material. We show that much of the spatial structure apparent in emission line images of jets arises from the dynamics and interactions of these bow shocks. Our simulations show a variety of time-dependent features, including bright knots associated with Mach stems where the shocks intersect, a “frothy” emission structure that arises from the presence of the Nonlinear Thin Shell Instability along the surfaces of the bow shocks, and the merging and fragmentation of clumps. Our simulations use a new non-equilibrium cooling method to produce synthetic emission maps in H α and [S ii]. These are directly compared to multi-epoch Hubble Space Telescope observations of Herbig–Haro jets. We find excellent agreement between features seen in the simulations and the observations in terms of both proper motion and morphologies. Thus we conclude that YSO jets may be dominated by heterogeneous structures and that interactions between these structures and the shocks they produce can account for many details of YSO jet evolution.

  16. Chimenea and other tools: Automated imaging of multi-epoch radio-synthesis data with CASA

    Science.gov (United States)

    Staley, T. D.; Anderson, G. E.

    2015-11-01

    In preparing the way for the Square Kilometre Array and its pathfinders, there is a pressing need to begin probing the transient sky in a fully robotic fashion using the current generation of radio telescopes. Effective exploitation of such surveys requires a largely automated data-reduction process. This paper introduces an end-to-end automated reduction pipeline, AMIsurvey, used for calibrating and imaging data from the Arcminute Microkelvin Imager Large Array. AMIsurvey makes use of several component libraries which have been packaged separately for open-source release. The most scientifically significant of these is chimenea, which implements a telescope-agnostic algorithm for automated imaging of pre-calibrated multi-epoch radio-synthesis data, of the sort typically acquired for transient surveys or follow-up. The algorithm aims to improve upon standard imaging pipelines by utilizing iterative RMS-estimation and automated source-detection to avoid so called 'Clean-bias', and makes use of CASA subroutines for the underlying image-synthesis operations. At a lower level, AMIsurvey relies upon two libraries, drive-ami and drive-casa, built to allow use of mature radio-astronomy software packages from within Python scripts. While targeted at automated imaging, the drive-casa interface can also be used to automate interaction with any of the CASA subroutines from a generic Python process. Additionally, these packages may be of wider technical interest beyond radio-astronomy, since they demonstrate use of the Python library pexpect to emulate terminal interaction with an external process. This approach allows for rapid development of a Python interface to any legacy or externally-maintained pipeline which accepts command-line input, without requiring alterations to the original code.

  17. MULTI-EPOCH OBSERVATIONS OF HD 69830: HIGH-RESOLUTION SPECTROSCOPY AND LIMITS TO VARIABILITY

    Energy Technology Data Exchange (ETDEWEB)

    Beichman, C. A.; Tanner, A. M.; Bryden, G.; Akeson, R. L.; Ciardi, D. R. [NASA Exoplanet Science Institute, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, 91125 (United States); Lisse, C. M. [Johns Hopkins University, Applied Physics Laboratory, Laurel, MD 20723 (United States); Boden, A. F. [Caltech Optical Observatories, California Institute of Technology, Pasadena, CA 91125 (United States); Dodson-Robinson, S. E.; Salyk, C. [University of Texas, Astronomy Department, Austin, TX 78712 (United States); Wyatt, M. C., E-mail: chas@pop.jpl.nasa.gov [Institute of Astronomy, University of Cambridge, Cambridge, CB3 0HA (United Kingdom)

    2011-12-10

    The main-sequence solar-type star HD 69830 has an unusually large amount of dusty debris orbiting close to three planets found via the radial velocity technique. In order to explore the dynamical interaction between the dust and planets, we have performed multi-epoch photometry and spectroscopy of the system over several orbits of the outer dust. We find no evidence for changes in either the dust amount or its composition, with upper limits of 5%-7% (1{sigma} per spectral element) on the variability of the dust spectrum over 1 year, 3.3% (1{sigma}) on the broadband disk emission over 4 years, and 33% (1{sigma}) on the broadband disk emission over 24 years. Detailed modeling of the spectrum of the emitting dust indicates that the dust is located outside of the orbits of the three planets and has a composition similar to main-belt, C-type asteroids in our solar system. Additionally, we find no evidence for a wide variety of gas species associated with the dust. Our new higher signal-to-noise spectra do not confirm our previously claimed detection of H{sub 2}O ice leading to a firm conclusion that the debris can be associated with the break-up of one or more C-type asteroids formed in the dry, inner regions of the protoplanetary disk of the HD 69830 system. The modeling of the spectral energy distribution and high spatial resolution observations in the mid-infrared are consistent with a {approx}1 AU location for the emitting material.

  18. Multi-band, multi-epoch observations of the transiting warm Jupiter WASP-80b

    Energy Technology Data Exchange (ETDEWEB)

    Fukui, Akihiko; Kuroda, Daisuke [Okayama Astrophysical Observatory, National Astronomical Observatory of Japan, Asakuchi, Okayama 719-0232 (Japan); Kawashima, Yui; Ikoma, Masahiro; Kurosaki, Kenji [Department of Earth and Planetary Science, Graduate School of Science, The University of Tokyo, 7-3-1 Bunkyo-ku, Tokyo 113-0033 (Japan); Narita, Norio; Nishiyama, Shogo; Takahashi, Yasuhiro H.; Nagayama, Shogo [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Onitsuka, Masahiro; Baba, Haruka; Ryu, Tsuguru [The Graduate University for Advanced Studies, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Ita, Yoshifusa; Onozato, Hiroki [Astronomical Institute, Graduate School of Science, Tohoku University, 6-3 Aramaki Aoba, Aoba-ku, Sendai, Miyagi 980-8578 (Japan); Hirano, Teruyuki; Kawauchi, Kiyoe [Department of Earth and Planetary Sciences, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551 (Japan); Hori, Yasunori [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Nagayama, Takahiro [Department of Physics, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602 (Japan); Tamura, Motohide [Department of Astronomy, Graduate School of Science, The University of Tokyo, and National Astronomical Observatory of Japan (Japan); Kawai, Nobuyuki, E-mail: afukui@oao.nao.ac.jp [Department of Physics, Tokyo Institute of Technology, 2-12-1, Oookayama, Meguro, Tokyo 152-8551 (Japan); and others

    2014-08-01

    WASP-80b is a warm Jupiter transiting a bright late-K/early-M dwarf, providing a good opportunity to extend the atmospheric study of hot Jupiters toward the lower temperature regime. We report multi-band, multi-epoch transit observations of WASP-80b by using three ground-based telescopes covering from optical (g', R{sub c}, and I{sub c} bands) to near-infrared (NIR; J, H, and K{sub s} bands) wavelengths. We observe 5 primary transits, each in 3 or 4 different bands simultaneously, obtaining 17 independent transit light curves. Combining them with results from previous works, we find that the observed transmission spectrum is largely consistent with both a solar abundance and thick cloud atmospheric models at a 1.7σ discrepancy level. On the other hand, we find a marginal spectral rise in the optical region compared to the NIR region at the 2.9σ level, which possibly indicates the existence of haze in the atmosphere. We simulate theoretical transmission spectra for a solar abundance but hazy atmosphere, finding that a model with equilibrium temperature of 600 K can explain the observed data well, having a discrepancy level of 1.0σ. We also search for transit timing variations, but find no timing excess larger than 50 s from a linear ephemeris. In addition, we conduct 43 day long photometric monitoring of the host star in the optical bands, finding no significant variation in the stellar brightness. Combined with the fact that no spot-crossing event is observed in the five transits, our results confirm previous findings that the host star appears quiet for spot activities, despite the indications of strong chromospheric activities.

  19. Faint Object Detection in Multi-Epoch Observations via Catalog Data Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Budavári, Tamás; Szalay, Alexander S. [Department of Physics and Astronomy, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Loredo, Thomas J. [Cornell Center for Astrophysics and Planetary Science, Cornell University, Ithaca, NY 14853 (United States)

    2017-03-20

    Astronomy in the time-domain era faces several new challenges. One of them is the efficient use of observations obtained at multiple epochs. The work presented here addresses faint object detection and describes an incremental strategy for separating real objects from artifacts in ongoing surveys. The idea is to produce low-threshold single-epoch catalogs and to accumulate information across epochs. This is in contrast to more conventional strategies based on co-added or stacked images. We adopt a Bayesian approach, addressing object detection by calculating the marginal likelihoods for hypotheses asserting that there is no object or one object in a small image patch containing at most one cataloged source at each epoch. The object-present hypothesis interprets the sources in a patch at different epochs as arising from a genuine object; the no-object hypothesis interprets candidate sources as spurious, arising from noise peaks. We study the detection probability for constant-flux objects in a Gaussian noise setting, comparing results based on single and stacked exposures to results based on a series of single-epoch catalog summaries. Our procedure amounts to generalized cross-matching: it is the product of a factor accounting for the matching of the estimated fluxes of the candidate sources and a factor accounting for the matching of their estimated directions. We find that probabilistic fusion of multi-epoch catalogs can detect sources with similar sensitivity and selectivity compared to stacking. The probabilistic cross-matching framework underlying our approach plays an important role in maintaining detection sensitivity and points toward generalizations that could accommodate variability and complex object structure.

  20. THE OPTICAL VARIABILITY OF SDSS QUASARS FROM MULTI-EPOCH SPECTROSCOPY. II. COLOR VARIATION

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Hengxiao; Gu, Minfeng, E-mail: hxguo@shao.ac.cn, E-mail: gumf@shao.ac.cn [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, Shanghai 200030 (China)

    2016-05-01

    We investigated the optical/ultraviolet (UV) color variations for a sample of 2169 quasars based on multi-epoch spectroscopy in the Sloan Digital Sky Survey data releases seven (DR7) and nine (DR9). To correct the systematic difference between DR7 and DR9 due to the different instrumental setup, we produced a correction spectrum by using a sample of F-stars observed in both DR7 and DR9. The correction spectrum was then applied to quasars when comparing the spectra of DR7 with DR9. In each object, the color variation was explored by comparing the spectral index of the continuum power-law fit on the brightest spectrum with the faintest one, and also by the shape of their difference spectrum. In 1876 quasars with consistent color variations from two methods, we found that most sources (1755, ∼94%) show the bluer-when-brighter (BWB) trend, and the redder-when-brighter (RWB) trend is detected in only 121 objects (∼6%). The common BWB trend is supported by the composite spectrum constructed from bright spectra, which is bluer than that from faint spectra, and also by the blue composite difference spectrum. The correction spectrum is proven to be highly reliable by comparing the composite spectrum from corrected DR9 and original DR7 spectra. Assuming that the optical/UV variability is triggered by fluctuations, the RWB trend can likely be explained if the fluctuations occur first in the outer disk region, and the inner disk region has not yet fully responded when the fluctuations are being propagated inward. In contrast, the common BWB trend implies that the fluctuations likely more often happen first in the inner disk region.

  1. Faint Object Detection in Multi-Epoch Observations via Catalog Data Fusion

    International Nuclear Information System (INIS)

    Budavári, Tamás; Szalay, Alexander S.; Loredo, Thomas J.

    2017-01-01

    Astronomy in the time-domain era faces several new challenges. One of them is the efficient use of observations obtained at multiple epochs. The work presented here addresses faint object detection and describes an incremental strategy for separating real objects from artifacts in ongoing surveys. The idea is to produce low-threshold single-epoch catalogs and to accumulate information across epochs. This is in contrast to more conventional strategies based on co-added or stacked images. We adopt a Bayesian approach, addressing object detection by calculating the marginal likelihoods for hypotheses asserting that there is no object or one object in a small image patch containing at most one cataloged source at each epoch. The object-present hypothesis interprets the sources in a patch at different epochs as arising from a genuine object; the no-object hypothesis interprets candidate sources as spurious, arising from noise peaks. We study the detection probability for constant-flux objects in a Gaussian noise setting, comparing results based on single and stacked exposures to results based on a series of single-epoch catalog summaries. Our procedure amounts to generalized cross-matching: it is the product of a factor accounting for the matching of the estimated fluxes of the candidate sources and a factor accounting for the matching of their estimated directions. We find that probabilistic fusion of multi-epoch catalogs can detect sources with similar sensitivity and selectivity compared to stacking. The probabilistic cross-matching framework underlying our approach plays an important role in maintaining detection sensitivity and points toward generalizations that could accommodate variability and complex object structure.

  2. Multi-epoch VLBA Imaging of 20 New TeV Blazars: Apparent Jet Speeds

    Science.gov (United States)

    Piner, B. Glenn; Edwards, Philip G.

    2018-01-01

    We present 88 multi-epoch Very Long Baseline Array (VLBA) images (most at an observing frequency of 8 GHz) of 20 TeV blazars, all of the high-frequency-peaked BL Lac (HBL) class, that have not been previously studied at multiple epochs on the parsec scale. From these 20 sources, we analyze the apparent speeds of 43 jet components that are all detected at four or more epochs. As has been found for other TeV HBLs, the apparent speeds of these components are relatively slow. About two-thirds of the components have an apparent speed that is consistent (within 2σ) with no motion, and some of these components may be stationary patterns whose apparent speed does not relate to the underlying bulk flow speed. In addition, a superluminal tail to the apparent speed distribution of the TeV HBLs is detected for the first time, with eight components in seven sources having a 2σ lower limit on the apparent speed exceeding 1c. We combine the data from these 20 sources with an additional 18 sources from the literature to analyze the complete apparent speed distribution of all 38 TeV HBLs that have been studied with very long baseline interferometry at multiple epochs. The highest 2σ apparent speed lower limit considering all sources is 3.6c. This suggests that bulk Lorentz factors of up to about 4, but probably not much higher, exist in the parsec-scale radio-emitting regions of these sources, consistent with estimates obtained in the radio by other means such as brightness temperatures. This can be reconciled with the high Lorentz factors estimated from the high-energy data if the jet has velocity structures consisting of different emission regions with different Lorentz factors. In particular, we analyze the current apparent speed data for the TeV HBLs in the context of a model with a fast central spine and a slower outer layer.

  3. Astrometry VLBI in Space (AVS)

    Science.gov (United States)

    Cheng, Li-Jen; Reyes, George

    1995-01-01

    This paper describes a proposal for a new space radio astronomy mission for astrometry using Very Long Baseline Interferometry (VLBI) called Astrometry VLBI in Space (AVS). The ultimate goals of AVS are improving the accuracy of radio astrometry measurements to the microarcsecond level in one epoch of measurements and improving the accuracy of the transformation between the inertial radio and optical coordinate reference frames. This study will also assess the impact of this mission on astrophysics astrometry and geophysics.

  4. Astrometry VLBI in Space (AVS

    Science.gov (United States)

    Altunin, V.; Alekseev, V.; Akim, E.; Eubanks, M.; Kingham, K.; Treuhaft, R.; Sukhanov, K.

    1995-01-01

    A proposed new space radio astronomy mission for astrometry is described. The Astrometry VLBI (very long baseline) in Space (AVS) nominal mission includes two identical spacecraft, each with a 4-m antenna sending data to a 70-m ground station. The goals of AVS are improving astrometry accuracy to the microarcsecond level and improving the accuracy of the transformation between the inertial radio and optical coordinate reference frames.

  5. A HIGH-RESOLUTION, MULTI-EPOCH SPECTRAL ATLAS OF PECULIAR STARS INCLUDING RAVE, GAIA , AND HERMES WAVELENGTH RANGES

    International Nuclear Information System (INIS)

    Tomasella, Lina; Munari, Ulisse; Zwitter, Tomaz

    2010-01-01

    We present an Echelle+CCD, high signal-to-noise ratio, high-resolution (R = 20,000) spectroscopic atlas of 108 well-known objects representative of the most common types of peculiar and variable stars. The wavelength interval extends from 4600 to 9400 A and includes the RAVE, Gaia, and HERMES wavelength ranges. Multi-epoch spectra are provided for the majority of the observed stars. A total of 425 spectra of peculiar stars, which were collected during 56 observing nights between 1998 November and 2002 August, are presented. The spectra are given in FITS format and heliocentric wavelengths, with accurate subtraction of both the sky background and the scattered light. Auxiliary material useful for custom applications (telluric dividers, spectrophotometric stars, flat-field tracings) is also provided. The atlas aims to provide a homogeneous database of the spectral appearance of stellar peculiarities, a tool useful both for classification purposes and inter-comparison studies. It could also serve in the planning and development of automated classification algorithms designed for RAVE, Gaia, HERMES, and other large-scale spectral surveys. The spectrum of XX Oph is discussed in some detail as an example of the content of the present atlas.

  6. Multi-epoch analysis of the X-ray spectrum of the active galactic nucleus in NGC 5506

    Science.gov (United States)

    Sun, Shangyu; Guainazzi, Matteo; Ni, Qingling; Wang, Jingchun; Qian, Chenyang; Shi, Fangzheng; Wang, Yu; Bambi, Cosimo

    2018-05-01

    We present a multi-epoch X-ray spectroscopy analysis of the nearby narrow-line Seyfert I galaxy NGC 5506. For the first time, spectra taken by Chandra, XMM-Newton, Suzaku, and NuSTAR - covering the 2000-2014 time span - are analyzed simultaneously, using state-of-the-art models to describe reprocessing of the primary continuum by optical thick matter in the AGN environment. The main goal of our study is determining the spin of the supermassive black hole (SMBH). The nuclear X-ray spectrum is photoelectrically absorbed by matter with column density ≃ 3 × 1022 cm-2. A soft excess is present at energies lower than the photoelectric cut-off. Both photo-ionized and collisionally ionized components are required to fit it. This component is constant over the time-scales probed by our data. The spectrum at energies higher than 2 keV is variable. We propose that its evolution could be driven by flux-dependent changes in the geometry of the innermost regions of the accretion disk. The black hole spin in NGC ,5506 is constrained to be 0.93± _{ 0.04 }^{0.04} at 90% confidence level for one interesting parameter.

  7. WFIRST: Astrometry with the Wide-Field Imager

    Science.gov (United States)

    Bellini, Andrea; WFIRST Astrometry Working Group

    2018-01-01

    The wide field of view and stable, sharp images delivered by WFIRST's Wide-Field Imager make it an excellent instrument for astrometry, one of five major discovery areas identified in the 2010 Decadal Survey. Compared to the Hubble Space Telescope, WFIRST's wider field of view with similar image quality will provide hundreds more astrometric targets per image as well as background galaxies and stars with precise positions in the Gaia catalog. In addition, WFIRST will operate in the infrared, a wavelength regime where the most precise astrometry has so far been achieved with adaptive optics images from large ground-based telescopes. WFIRST will provide at least a factor of three improvement in astrometry over the current state of the art in this wavelength range, while spanning a field of view thousands of times larger. WFIRST is thus poised to make major contributions to multiple science topics in which astrometry plays an important role, without major alterations to the planned mission or instrument. We summarize a few of the most compelling science cases where WFIRST astrometry could prove transformational.

  8. Astrometry with A-Track Using Gaia DR1 Catalogue

    Science.gov (United States)

    Kılıç, Yücel; Erece, Orhan; Kaplan, Murat

    2018-04-01

    In this work, we built all sky index files from Gaia DR1 catalogue for the high-precision astrometric field solution and the precise WCS coordinates of the moving objects. For this, we used build-astrometry-index program as a part of astrometry.net code suit. Additionally, we added astrometry.net's WCS solution tool to our previously developed software which is a fast and robust pipeline for detecting moving objects such as asteroids and comets in sequential FITS images, called A-Track. Moreover, MPC module was added to A-Track. This module is linked to an asteroid database to name the found objects and prepare the MPC file to report the results. After these innovations, we tested a new version of the A-Track code on photometrical data taken by the SI-1100 CCD with 1-meter telescope at TÜBİTAK National Observatory, Antalya. The pipeline can be used to analyse large data archives or daily sequential data. The code is hosted on GitHub under the GNU GPL v3 license.

  9. Global astrometry with the space interferometry mission

    Science.gov (United States)

    Boden, A.; Unwin, S.; Shao, M.

    1997-01-01

    The prospects for global astrometric measurements with the space interferometry mission (SIM) are discussed. The SIM mission will perform four microarcsec astrometric measurements on objects as faint as 20 mag using the optical interferometry technique with a 10 m baseline. The SIM satellite will perform narrow angle astrometry and global astrometry by means of an astrometric grid. The sensitivities of the SIM global astrometric performance and the grid accuracy versus instrumental parameters and sky coverage schemes are reported on. The problems in finding suitable astrometric grid objects to support microarcsec astrometry, and related ground-based observation programs are discussed.

  10. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    Energy Technology Data Exchange (ETDEWEB)

    Dzib, Sergio A.; Rodriguez, Luis F.; Loinard, Laurent; Ortiz-Leon, Gisela N.; Araudo, Anabella T. [Centro de Radiostronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Morelia 58089 (Mexico); Mioduszewski, Amy J., E-mail: s.dzib@crya.unam.mx [National Radio Astronomy Observatory, 1003 Lopezville Road, Socorro, NM 87801 (United States)

    2013-02-15

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 {+-} 0.22 mas, corresponding to a distance of 1.65 {sup +0.96} {sub -0.44} kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  11. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    International Nuclear Information System (INIS)

    Dzib, Sergio A.; Rodríguez, Luis F.; Loinard, Laurent; Ortiz-León, Gisela N.; Araudo, Anabella T.; Mioduszewski, Amy J.

    2013-01-01

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 ± 0.22 mas, corresponding to a distance of 1.65 +0.96 –0.44 kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  12. Astrometry of 2014MU69 for New Horizons encounter

    Science.gov (United States)

    Buie, Marc

    2017-08-01

    We propose 12 orbits of time to make high-precision astrometric measurments of the New Horizons extendedmission target, (486958) 2014MU69. These observations are in direct support of the navigation of New Horizonsleading up to its encounter in Jan 2019. These visits represent an optimized plan for improved orbit estimates that willcomplete as the target becomes directly observable by New Horizons. This astrometry is a key element leadingup to a close investigation of a Cold-Classical Kuiper Belt Object, one of the most primitive members of our solarsystem.

  13. THE MULTI-EPOCH NEARBY CLUSTER SURVEY: TYPE Ia SUPERNOVA RATE MEASUREMENT IN z ∼ 0.1 CLUSTERS AND THE LATE-TIME DELAY TIME DISTRIBUTION

    International Nuclear Information System (INIS)

    Sand, David J.; Graham, Melissa L.; Bildfell, Chris; Pritchet, Chris; Zaritsky, Dennis; Just, Dennis W.; Herbert-Fort, Stéphane; Hoekstra, Henk; Sivanandam, Suresh; Foley, Ryan J.; Mahdavi, Andisheh

    2012-01-01

    We describe the Multi-Epoch Nearby Cluster Survey, designed to measure the cluster Type Ia supernova (SN Ia) rate in a sample of 57 X-ray selected galaxy clusters, with redshifts of 0.05 200 (1 Mpc) of 0.042 +0.012 –0.010 +0.010 –0.008 SNuM (0.049 +0.016 –0.014 +0.005 –0.004 SNuM) and an SN Ia rate within red-sequence galaxies of 0.041 +0.015 –0.015 +0.005 –0.010 SNuM (0.041 +0.019 –0.015 +0.005 –0.004 SNuM). The red-sequence SN Ia rate is consistent with published rates in early-type/elliptical galaxies in the 'field'. Using our red-sequence SN Ia rate, and other cluster SN measurements in early-type galaxies up to z ∼ 1, we derive the late-time (>2 Gyr) delay time distribution (DTD) of SN Ia assuming a cluster early-type galaxy star formation epoch of z f = 3. Assuming a power-law form for the DTD, Ψ(t)∝t s , we find s = –1.62 ± 0.54. This result is consistent with predictions for the double degenerate SN Ia progenitor scenario (s ∼ –1) and is also in line with recent calculations for the double detonation explosion mechanism (s ∼ –2). The most recent calculations of the single degenerate scenario DTD predicts an order-of-magnitude drop-off in SN Ia rate ∼6-7 Gyr after stellar formation, and the observed cluster rates cannot rule this out.

  14. Asteroid families, dynamics and astrometry

    International Nuclear Information System (INIS)

    Williams, J.G.; Gibson, J.

    1987-01-01

    The proper elements and family assignments for the 1227 Palomar-Leiden Survey asteroids of high quality were tabulated. In addition to the large table, there are also auxiliary tables of Mars crossers and commensurate objects, histograms of the proper element distributions, and a discussion. Probably the most important part of the discussion describes the Mars crossing boundary, how the closest distances of approach to Mars and Jupiter are calculated, and why the observed population of Mars crossers should bombard that planet episodically rather than uniformly. Analytical work was done to derive velocity distributions of family forming events from proper element distributions subject to assumptions which may be appropriate for cratering events. Software was developed for a microcomputer to permit plotting of the proper elements. Three orthogonal views are generated and stereo pairs can be printed when desired. This program was created for the study of asteroid families. The astrometry task is directed toward measuring and reducing positions on faint comets and the minor planets with less common orbits. The observational material is CCD frames taken with the Palomar 1.5 m telescope. Positions of 10 comets and 16 different asteroids were published on the Minor Planet Circulars

  15. The Future of Astrometry in Space

    Directory of Open Access Journals (Sweden)

    Antonella Vallenari

    2018-04-01

    Full Text Available This contribution focuses on the importance of astrometry and on its future developments. Over the centuries astrometry has greatly contributed to the advance of the knowledge of the Universe. Nowadays a major breakthrough is on the way due to astrometric sky surveys from space. ESA space missions Hipparcos first and then Gaia point out the outstanding contribution that space astrometry can provide to our knowledge in many fields of astrophysics, going from the Milky Way formation and evolution, to stellar astrophysics, extra-galactic astrophysics, and fundamental physics. We briefly outline the properties of Gaia first and second data release, and the accuracies expected end-of-mission. The next big advance in space astrometry would be either to improve the astrometric accuracy of one order of magnitude, or to move to a different wavelength domain. While both options have the potential to bring us in a new era of discovery, they have to face enormous issues. We summarize the future directions in space astrometry that are proposed or under investigation by the scientific community, their main challenges and the expected outcome.

  16. THE TYPE II SUPERNOVA RATE IN z {approx} 0.1 GALAXY CLUSTERS FROM THE MULTI-EPOCH NEARBY CLUSTER SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Graham, M. L.; Sand, D. J. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Bildfell, C. J.; Pritchet, C. J. [Department of Physics and Astronomy, University of Victoria, P.O. Box 3055, STN CSC, Victoria BC V8W 3P6 (Canada); Zaritsky, D.; Just, D. W.; Herbert-Fort, S. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Hoekstra, H. [Leiden Observatory, Leiden University, Niels Bohrweg 2, NL-2333 CA Leiden (Netherlands); Sivanandam, S. [Dunlap Institute for Astronomy and Astrophysics, 50 St. George St., Toronto, ON M5S 3H4 (Canada); Foley, R. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2012-07-01

    We present seven spectroscopically confirmed Type II cluster supernovae (SNe II) discovered in the Multi-Epoch Nearby Cluster Survey, a supernova survey targeting 57 low-redshift 0.05 < z < 0.15 galaxy clusters with the Canada-France-Hawaii Telescope. We find the rate of Type II supernovae within R{sub 200} of z {approx} 0.1 galaxy clusters to be 0.026{sup +0.085}{sub -0.018}(stat){sup +0.003}{sub -0.001}(sys) SNuM. Surprisingly, one SN II is in a red-sequence host galaxy that shows no clear evidence of recent star formation (SF). This is unambiguous evidence in support of ongoing, low-level SF in at least some cluster elliptical galaxies, and illustrates that galaxies that appear to be quiescent cannot be assumed to host only Type Ia SNe. Based on this single SN II we make the first measurement of the SN II rate in red-sequence galaxies, and find it to be 0.007{sup +0.014}{sub -0.007}(stat){sup +0.009}{sub -0.001}(sys) SNuM. We also make the first derivation of cluster specific star formation rates (sSFR) from cluster SN II rates. We find that for all galaxy types the sSFR is 5.1{sup +15.8}{sub -3.1}(stat) {+-} 0.9(sys) M{sub Sun} yr{sup -1} (10{sup 12} M{sub Sun }){sup -1}, and for red-sequence galaxies only it is 2.0{sup +4.2}{sub -0.9}(stat) {+-} 0.4(sys) M{sub Sun} yr{sup -1} (10{sup 12} M{sub Sun }){sup -1}. These values agree with SFRs measured from infrared and ultraviolet photometry, and H{alpha} emission from optical spectroscopy. Additionally, we use the SFR derived from our SNII rate to show that although a small fraction of cluster Type Ia SNe may originate in the young stellar population and experience a short delay time, these results do not preclude the use of cluster SN Ia rates to derive the late-time delay time distribution for SNe Ia.

  17. THE MULTI-EPOCH NEARBY CLUSTER SURVEY: TYPE Ia SUPERNOVA RATE MEASUREMENT IN z {approx} 0.1 CLUSTERS AND THE LATE-TIME DELAY TIME DISTRIBUTION

    Energy Technology Data Exchange (ETDEWEB)

    Sand, David J.; Graham, Melissa L. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Bildfell, Chris; Pritchet, Chris [Department of Physics and Astronomy, University of Victoria, P.O. Box 3055, STN CSC, Victoria BC V8W 3P6 (Canada); Zaritsky, Dennis; Just, Dennis W.; Herbert-Fort, Stephane [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Hoekstra, Henk [Leiden Observatory, Leiden University, Niels Bohrweg 2, NL-2333 CA Leiden (Netherlands); Sivanandam, Suresh [Dunlap Institute for Astronomy and Astrophysics, 50 St. George Street, Toronto, ON M5S 3H4 (Canada); Foley, Ryan J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Mahdavi, Andisheh, E-mail: dsand@lcogt.net [Department of Physics and Astronomy, San Francisco State University, San Francisco, CA 94132 (United States)

    2012-02-20

    We describe the Multi-Epoch Nearby Cluster Survey, designed to measure the cluster Type Ia supernova (SN Ia) rate in a sample of 57 X-ray selected galaxy clusters, with redshifts of 0.05 < z < 0.15. Utilizing our real-time analysis pipeline, we spectroscopically confirmed twenty-three cluster SNe Ia, four of which were intracluster events. Using our deep Canada-France-Hawaii Telescope/MegaCam imaging, we measured total stellar luminosities in each of our galaxy clusters, and we performed detailed supernova (SN) detection efficiency simulations. Bringing these ingredients together, we measure an overall cluster SN Ia rate within R{sub 200} (1 Mpc) of 0.042{sup +0.012}{sub -0.010}{sup +0.010}{sub -0.008} SNuM (0.049{sup +0.016}{sub -0.014}{sup +0.005}{sub -0.004} SNuM) and an SN Ia rate within red-sequence galaxies of 0.041{sup +0.015}{sub -0.015}{sup +0.005}{sub -0.010} SNuM (0.041{sup +0.019}{sub -0.015}{sup +0.005}{sub -0.004} SNuM). The red-sequence SN Ia rate is consistent with published rates in early-type/elliptical galaxies in the 'field'. Using our red-sequence SN Ia rate, and other cluster SN measurements in early-type galaxies up to z {approx} 1, we derive the late-time (>2 Gyr) delay time distribution (DTD) of SN Ia assuming a cluster early-type galaxy star formation epoch of z{sub f} = 3. Assuming a power-law form for the DTD, {Psi}(t){proportional_to}t{sup s} , we find s = -1.62 {+-} 0.54. This result is consistent with predictions for the double degenerate SN Ia progenitor scenario (s {approx} -1) and is also in line with recent calculations for the double detonation explosion mechanism (s {approx} -2). The most recent calculations of the single degenerate scenario DTD predicts an order-of-magnitude drop-off in SN Ia rate {approx}6-7 Gyr after stellar formation, and the observed cluster rates cannot rule this out.

  18. Ground-based Opportunities for Astrometry

    Science.gov (United States)

    2013-01-01

    science that is possible. The starting points for many of these projects are the surveys, such as 2MASS , DENIS, and the SDSS recently made with...Cutri, R. M. (2006). Extending the JCRF into the infrared: 2MASS -UCAC astrometry. In JDJ6: The International Celestial Reference Ssytem: Maintenance

  19. Microarcsecond relative astrometry from the ground with a diffractive pupil

    Energy Technology Data Exchange (ETDEWEB)

    Ammons, S M; Bendek, E; Guyon, O

    2011-09-08

    The practical use of astrometry to detect exoplanets via the reflex motion of the parent star depends critically on the elimination of systematic floors in imaging systems. In the diffractive pupil technique proposed for space-based detection of exo-earths, extended diffraction spikes generated by a dotted primary mirror are referenced against a wide-field grid of background stars to calibrate changing optical distortion and achieve microarcsecond astrometric precision on bright targets (Guyon et al. 2010). We describe applications of this concept to ground-based uncrowded astrometry using a diffractive, monopupil telescope and a wide-field camera to image as many as {approx}4000 background reference stars. Final relative astrometric precision is limited by differential tip/tilt jitter caused by high altitude layers of turbulence. A diffractive 3-meter telescope is capable of reaching {approx}35 {micro}as relative astrometric error per coordinate perpendicular to the zenith vector in three hours on a bright target star (I < 10) in fields of moderate stellar density ({approx}40 stars arcmin{sup -2} with I < 23). Smaller diffractive apertures (D < 1 m) can achieve 100-200 {micro}as performance with the same stellar density and exposure time and a large telescope (6.5-10 m) could achieve as low as 10 {micro}as, nearly an order of magnitude better than current space-based facilities. The diffractive pupil enables the use of larger fields of view through calibration of changing optical distortion as well as brighter target stars (V < 6) by preventing star saturation. Permitting the sky to naturally roll to average signals over many thousands of pixels can mitigate the effects of detector imperfections.

  20. Observational Model for Precision Astrometry with the Space Interferometry Mission

    National Research Council Canada - National Science Library

    Turyshev, Slava G; Milman, Mark H

    2000-01-01

    The Space Interferometry Mission (SIM) is a space-based 10-m baseline Michelson optical interferometer operating in the visible waveband that is designed to achieve astrometric accuracy in the single digits of the microarcsecond domain...

  1. High Accuracy Ground-based near-Earth-asteroid Astrometry using Synthetic Tracking

    Science.gov (United States)

    Zhai, Chengxing; Shao, Michael; Saini, Navtej; Sandhu, Jagmit; Werne, Thomas; Choi, Philip; Ely, Todd A.; Jacobs, Chirstopher S.; Lazio, Joseph; Martin-Mur, Tomas J.; Owen, William M.; Preston, Robert; Turyshev, Slava; Michell, Adam; Nazli, Kutay; Cui, Isaac; Monchama, Rachel

    2018-01-01

    Accurate astrometry is crucial for determining the orbits of near-Earth-asteroids (NEAs). Further, the future of deep space high data rate communications is likely to be optical communications, such as the Deep Space Optical Communications package that is part of the baseline payload for the planned Psyche Discovery mission to the Psyche asteroid. We have recently upgraded our instrument on the Pomona College 1 m telescope, at JPL's Table Mountain Facility, for conducting synthetic tracking by taking many short exposure images. These images can be then combined in post-processing to track both asteroid and reference stars to yield accurate astrometry. Utilizing the precision of the current and future Gaia data releases, the JPL-Pomona College effort is now demonstrating precision astrometry on NEAs, which is likely to be of considerable value for cataloging NEAs. Further, treating NEAs as proxies of future spacecraft that carry optical communication lasers, our results serve as a measure of the astrometric accuracy that could be achieved for future plane-of-sky optical navigation.

  2. THE BENEFITS OF VLBI ASTROMETRY TO PULSAR TIMING ARRAY SEARCHES FOR GRAVITATIONAL RADIATION

    Energy Technology Data Exchange (ETDEWEB)

    Madison, D. R.; Chatterjee, S.; Cordes, J. M. [Department of Astronomy and Center for Radiophysics and Space Research, Cornell University, Ithaca, NY 14850 (United States)

    2013-11-10

    Precision astrometry is an integral component of successful pulsar timing campaigns. Astrometric parameters are commonly derived by fitting them as parameters of a timing model to a series of pulse times of arrival (TOAs). TOAs measured to microsecond precision over spans of several years can yield position measurements with sub-milliarcsecond precision. However, timing-based astrometry can become biased if a pulsar displays any red spin noise or a red signal produced by the stochastic gravitational wave background. We investigate how noise of different spectral types is absorbed by timing models, leading to significant estimation biases in the astrometric parameters. We find that commonly used techniques for fitting timing models in the presence of red noise (Cholesky whitening) prevent the absorption of noise into the timing model remarkably well if the time baseline of observations exceeds several years, but are inadequate for dealing with shorter pulsar data sets. Independent of timing, pulsar-optimized very long baseline interferometry (VLBI) is capable of providing position estimates precise to the sub-milliarcsecond levels needed for high-precision timing. In order to make VLBI astrometric parameters useful in pulsar timing models, the transformation between the International Celestial Reference Frame (ICRF) and the dynamical solar system ephemeris used for pulsar timing must be constrained to within a few microarcseconds. We compute a transformation between the ICRF and pulsar timing frames and quantitatively discuss how the transformation will improve in coming years. We find that incorporating VLBI astrometry into the timing models of pulsars for which only a couple of years of timing data exist will lead to more realistic assessments of red spin noise and could enhance the amplitude of gravitational wave signatures in post-fit timing residuals by factors of 20 or more.

  3. International VLBI Service for Geodesy and Astrometry

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

    2001-01-01

    This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2000 Annual Report documents the work of these IVS components over the period March 1, 1999, through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000.

  4. Atmospheric scintillation at Dome C, Antarctica: implications for photometry and astrometry

    Science.gov (United States)

    Kenyon, S.; Lawrence, J.; Ashley, M. C. B.; Storey, J. W. V.; Tokovinin, A.; Fossat, E.

    2006-08-01

    Night-time turbulence profiles of the atmosphere above Dome C, Antarctica, were measured during 2004, using a MASS instrument. We compare this data with turbulence profiles above Cerro Tololo and Cerro Pachon, also measured with a MASS, and find, with the exception of the owest layer, that Dome C has significantly less turbulence. In addition, the integrated at turbulence 16 km above Dome C is always less than the median values at the two Chilean sites. Using average wind speed profiles, we assess the photometric noise produced by scintillation, and the atmospheric contribution to the error budget in narrow angle differential astrometry. In comparison with the two mid-latitude sites in Chile, Dome C offers a potential gain of about 3.6 in both photometric precision (for long integrations) and narrow-angle astrometry precision. Although the data from Dome C cover a fairly limited time frame, they lend strong support to expectations that Dome C will offer significant advantages for photometric and astrometric studies.

  5. VLBI: A Fascinating Technique for Geodesy and Astrometry

    Science.gov (United States)

    Schuh, H.; Behrend, Dirk

    2012-01-01

    Since the 1970s Very Long Baseline Interferometry (VLBI) has proven to be a primary space-geodetic technique by determining precise coordinates on the Earth, by monitoring the variable Earth rotation and orientation with highest precision, and by deriving many other parameters of the Earth system. VLBI provides an important linkage to astronomy through, for instance, the determination of very precise coordinates of extragalactic radio sources. Additionally, it contributes to determining parameters of relativistic and cosmological models. After a short review of the history of geodetic VLBI and a summary of recent results, this paper describes future perspectives of this fascinating technique. The International VLBI Service for Geodesy and Astrometry (IVS), as a service of the International Association of Geodesy (IAG) and the International Astronomical Union (IAU), is well on its way to fully defining a next generation VLBI system, called VLBI2010. The goals of the new system are to achieve on scales up to the size of the Earth an accuracy of 1 mm in position and of 0.1 mm/year in velocity. Continuous observations shall be carried out 24 h per day 7 days per week in the future with initial results to be delivered within 24 h after taking the data. Special sessions, e.g. for monitoring the Earth rotation parameters, will provide the results in near real-time. These goals require a completely new technical and conceptual design of VLBI measurements. Based on extensive simulation studies, strategies have been developed by the IVS to significantly improve its product accuracy through the use of a network of small (approx 12 m) fast-slewing antennas. A new method for generating high precision delay measurements as well as improved methods for handling biases related to radio source structure, system electronics, and deformations of the antenna structures has been developed. Furthermore, as of January 2012, the construction of ten new VLBI2010 sites has been funded, with

  6. THE PHASES DIFFERENTIAL ASTROMETRY DATA ARCHIVE. II. UPDATED BINARY STAR ORBITS AND A LONG PERIOD ECLIPSING BINARY

    International Nuclear Information System (INIS)

    Muterspaugh, Matthew W.; O'Connell, J.; Hartkopf, William I.; Lane, Benjamin F.; Williamson, M.; Kulkarni, S. R.; Konacki, Maciej; Burke, Bernard F.; Colavita, M. M.; Shao, M.; Wiktorowicz, Sloane J.

    2010-01-01

    Differential astrometry measurements from the Palomar High-precision Astrometric Search for Exoplanet Systems have been combined with lower precision single-aperture measurements covering a much longer timespan (from eyepiece measurements, speckle interferometry, and adaptive optics) to determine improved visual orbits for 20 binary stars. In some cases, radial velocity observations exist to constrain the full three-dimensional orbit and determine component masses. The visual orbit of one of these binaries-α Com (HD 114378)-shows that the system is likely to have eclipses, despite its very long period of 26 years. The next eclipse is predicted to be within a week of 2015 January 24.

  7. Introducing ADES: A New IAU Astrometry Data Exchange Standard

    Science.gov (United States)

    Chesley, Steven R.; Hockney, George M.; Holman, Matthew J.

    2017-10-01

    For several decades, small body astrometry has been exchanged, distributed and archived in the form of 80-column ASCII records. As a replacement for this obsolescent format, we have worked with a number of members of the community to develop the Astrometric Data Exchange Standard (ADES), which was formally adopted by IAU Commission 20 in August 2015 at the XXIX General Assembly in Honolulu, Hawaii.The purpose of ADES is to ensure that useful and available observational information is submitted, archived, and disseminated as needed. Availability of more complete information will allow orbit computers to process the data more correctly, leading to improved accuracy and reliability of orbital fits. In this way, it will be possible to fully exploit the improving accuracy and increasing number of both optical and radar observations. ADES overcomes several limitations of the previous format by allowing characterization of astrometric and photometric errors, adequate precision in time and angle fields, and flexibility and extensibility.To accommodate a diverse base of users, from automated surveys to hands-on follow-up observers, the ADES protocol allows for two file formats, eXtensible Markup Language (XML) and Pipe-Separated Values (PSV). Each format carries the same information and simple tools allow users to losslessly transform back and forth between XML and PSV.We have further developed and refined ADES since it was first announced in July 2015 [1]. The proposal at that time [2] has undergone several modest revisions to aid validation and avoid overloaded fields. We now have validation schema and file transformation utilities. Suitable example files, test suites, and input/output libraries in a number of modern programming languages are now available. Acknowledgements: Useful feedback during the development of ADES has been received from numerous colleagues in the community of observers and orbit specialists working on asteroids comets and planetary satellites

  8. Relative astrometry of compact flaring structures in Sgr A* with polarimetric very long baseline interferometry

    International Nuclear Information System (INIS)

    Johnson, Michael D.; Doeleman, Sheperd S.; Fish, Vincent L.; Broderick, Avery E.; Wardle, John F. C.; Marrone, Daniel P.

    2014-01-01

    We demonstrate that polarimetric interferometry can be used to extract precise spatial information about compact polarized flares of Sgr A*. We show that, for a faint dynamical component, a single interferometric baseline suffices to determine both its polarization and projected displacement from the quiescent intensity centroid. A second baseline enables two-dimensional reconstruction of the displacement, and additional baselines can self-calibrate using the flare, enhancing synthesis imaging of the quiescent emission. We apply this technique to simulated 1.3 mm wavelength observations of a 'hot spot' embedded in a radiatively inefficient accretion disk around Sgr A*. Our results indicate that, even with current sensitivities, polarimetric interferometry with the Event Horizon Telescope can achieve ∼5 μas relative astrometry of compact flaring structures near Sgr A* on timescales of minutes.

  9. Absolute Astrometry in the next 50 Years - II

    Science.gov (United States)

    Høg, E.

    2018-01-01

    With the Gaia astrometric satellite in orbit since December 2013 it is time to look at the future of fundamental astrometry and a time frame of 50 years is needed in this matter. A space mission with Gaia-like astrometric performance is required, but not necessarily a Gaia-like satellite. A dozen science issues for a Gaia successor mission in twenty years, with launch about 2035, are presented and in this context also other possibilities for absolute astrometry with milliarcsecond (mas) or sub-mas accuracies are discussed in my report at http://arxiv.org/abs/1408.2190. In brief, the two missions (2013 and 2035) would provide an astrometric foundation for all branches of astronomy from the solar system and stellar systems, including exo-planet systems with long periods, to compact galaxies, quasars and Dark Matter substructures by data which cannot be surpassed in the next 50 years.

  10. Deriving the true mass of an unresolved Brown Dwarf companion to an M-Dwarf with AO aided astrometry*

    Directory of Open Access Journals (Sweden)

    Kürster M.

    2011-07-01

    Full Text Available From radial velocity (RV detections alone one does not get all orbital parameters needed to derive the true mass of a non-transiting, unresolved substellar companion to a star. Additional astrometric measurements are needed to calculate the inclination and the longitude of the ascending node. Until today only few true substellar companion masses have been determined by this method with the HST fine guidance sensor [1, 2]. We aim to derive the true mass of a brown dwarf candidate companion to an early M 2.5V dwarf with groundbased high-resolution astrometry aided by adaptive optics. We found this unique brown dwarf desert object, whose distance to the host star is only 0.42 AU, in our UVES precision RV survey of M dwarfs, inferring a minimum companion mass of 27 Jupiter masses [3]. Combining the data with HIPPARCOS astrometry, we found a probability of only 2.9% that the companion is stellar. We therefore observed the host star together with a reference star within a monitoring program with VLT/NACO to derive the true mass of the companion and establish its nature (brown dwarf vs. star. Simultaneous observations of a reference field in a globular cluster are performed to determine the stability of the adaptive optics (AO plus detector system and check its suitability for such high-precision astrometric measurements over several epochs which are needed to find and analyse extrasolar planet systems.

  11. International VLBI Service for Geodesy and Astrometry 2007 Annual Report

    Science.gov (United States)

    Behrend, D. (Editor); Baver, K. D. (Editor)

    2008-01-01

    This volume of reports is the 2007 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2007 Annual Report documents the work of these IVS components over the period January 1, 2007 through December 31, 2007. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2007.

  12. International VLBI Service for Geodesy and Astrometry 2008 Annual Report

    Science.gov (United States)

    Behrend, Dirk; Baver, Karen D.

    2009-01-01

    This volume of reports is the 2008 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2008 Annual Report documents the work of these IVS components over the period January 1, 2008 through December 31, 2008. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2008.

  13. International VLBI Service for Geodesy and Astrometry 2011 Annual Report

    Science.gov (United States)

    Baver, Karen D. (Editor); Behrend, Dirk

    2012-01-01

    This volume of reports is the 2011 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2011 Annual Report documents the work of these IVS components over the period January 1, 2011 through December 31, 2011. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2011.

  14. International VLBI Service for Geodesy and Astrometry 2005 Annual Report

    Science.gov (United States)

    Behrend, Dirk (Editor); Baver, Karen D. (Editor)

    2006-01-01

    This volume of reports is the 2005 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the components of IVS. The 2005 Annual Report documents the work of these IVS components over the period January 1, 2005 through December 31, 2005. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2005.

  15. Modernizing Pickles - A Tool for Planning and Scheduling HST Astrometry

    Science.gov (United States)

    Juarez, Aaron; McArthur, B.; Benedict, G. F.

    2007-12-01

    Pickles is a Macintosh program written in C that was developed as a tool for determining pointings and rolls of the Hubble Space Telescope (HST) to place targets and astrometric reference stars in the Fine Guidance Sensor (FGS) field of regard ("pickles"). The program was developed in the late 1980s and runs under the "Classic” System. Ongoing HST astrometry projects require that this code be ported to the Intel-Mac OSX, because the Classic System is now unsupported. Pickles is a vital part of HST astrometry research. It graphically aids the investigator to determine where, when, and how the HST/FGS combination can observe an object and associated astrometric reference stars. Presently, Pickles can extract and display star positions from Guide Star Catalogs, such as the ACRS, SAO, and AGK3 catalogs via CD-ROMs. Future improvements will provide access to these catalogs and others through the internet. As an example of the past utility of Pickles, we highlight the recent determination of parallaxes for ten galactic Cepheids to determine an improved solar-metallicity Period-Luminosity relation. Support for this work was provided by NASA through grants GO-10989, -11210, and -11211 from the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.

  16. Modeling Multi-wavelength Stellar Astrometry. III. Determination of the Absolute Masses of Exoplanets and Their Host Stars

    Science.gov (United States)

    Coughlin, J. L.; López-Morales, Mercedes

    2012-05-01

    Astrometric measurements of stellar systems are becoming significantly more precise and common, with many ground- and space-based instruments and missions approaching 1 μas precision. We examine the multi-wavelength astrometric orbits of exoplanetary systems via both analytical formulae and numerical modeling. Exoplanets have a combination of reflected and thermally emitted light that causes the photocenter of the system to shift increasingly farther away from the host star with increasing wavelength. We find that, if observed at long enough wavelengths, the planet can dominate the astrometric motion of the system, and thus it is possible to directly measure the orbits of both the planet and star, and thus directly determine the physical masses of the star and planet, using multi-wavelength astrometry. In general, this technique works best for, though is certainly not limited to, systems that have large, high-mass stars and large, low-mass planets, which is a unique parameter space not covered by other exoplanet characterization techniques. Exoplanets that happen to transit their host star present unique cases where the physical radii of the planet and star can be directly determined via astrometry alone. Planetary albedos and day-night contrast ratios may also be probed via this technique due to the unique signature they impart on the observed astrometric orbits. We develop a tool to examine the prospects for near-term detection of this effect, and give examples of some exoplanets that appear to be good targets for detection in the K to N infrared observing bands, if the required precision can be achieved.

  17. MODELING MULTI-WAVELENGTH STELLAR ASTROMETRY. III. DETERMINATION OF THE ABSOLUTE MASSES OF EXOPLANETS AND THEIR HOST STARS

    International Nuclear Information System (INIS)

    Coughlin, J. L.; López-Morales, Mercedes

    2012-01-01

    Astrometric measurements of stellar systems are becoming significantly more precise and common, with many ground- and space-based instruments and missions approaching 1 μas precision. We examine the multi-wavelength astrometric orbits of exoplanetary systems via both analytical formulae and numerical modeling. Exoplanets have a combination of reflected and thermally emitted light that causes the photocenter of the system to shift increasingly farther away from the host star with increasing wavelength. We find that, if observed at long enough wavelengths, the planet can dominate the astrometric motion of the system, and thus it is possible to directly measure the orbits of both the planet and star, and thus directly determine the physical masses of the star and planet, using multi-wavelength astrometry. In general, this technique works best for, though is certainly not limited to, systems that have large, high-mass stars and large, low-mass planets, which is a unique parameter space not covered by other exoplanet characterization techniques. Exoplanets that happen to transit their host star present unique cases where the physical radii of the planet and star can be directly determined via astrometry alone. Planetary albedos and day-night contrast ratios may also be probed via this technique due to the unique signature they impart on the observed astrometric orbits. We develop a tool to examine the prospects for near-term detection of this effect, and give examples of some exoplanets that appear to be good targets for detection in the K to N infrared observing bands, if the required precision can be achieved.

  18. International VLBI Service for Geodesy and Astrometry: 1999 Annual Report

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor)

    1999-01-01

    This volume of reports is the 1999 Annual Report of the International VLBI Service for Geodesy and Astrometry -IVS. The individual reports were contributed by VLBI groups in the international geodetic community who constitute the components of IVS. The 1999 Annual Report documents the work of the IVS components for the year ending March 1, 1999, the official inauguration date of IVS. As the newest of the space technique services, IVS decided to publish this Annual Report as a reference to our organization and its components. The entire contents of this Annual Report also appear on the IVS website at: http://ivscc.gsfc.nasa.gov/pub/arl999. The IVS 1999 Annual Report will be a valuable reference for information about IVS and its components. This Annual Report will serve as a baseline from which we can measure the anticipated progress of IVS in coming years.

  19. International VLBI Service for Geodesy and Astrometry 2012 Annual Report

    Science.gov (United States)

    Baver, Karen D.; Behrend, Dirk; Armstrong, Kyla L.

    2013-01-01

    This volume of reports is the 2012 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2012 Annual Report documents the work of the IVS components for the calendar year 2012, our fourteenth year of existence. The reports describe changes, activities, and progress ofthe IVS. Many thanks to all IVS components who contributed to this Annual Report. With the exception of the first section and parts of the last section (described below), the contents of this Annual Report also appear on the IVS Web site athttp:ivscc.gsfc.nasa.gov/publications/ar2012

  20. International VLBI Service for Geodesy and Astrometry 2013 Annual Report

    Science.gov (United States)

    Baver, Karen D.; Behrend, Dirk; Armstrong, Kyla L.

    2014-01-01

    This volume of reports is the 2013 Annual Report of the International VLBI Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2013 Annual Report documents the work of the IVS components for the calendar year 2013, our fifteenth year of existence. The reports describe changes, activities, and progress of the IVS. Many thanks to all IVS components who contributed to this Annual Report. With the exception of the first section and the last section, the contents of this Annual Report also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/ar2013.

  1. Some new results on the central overlap problem in astrometry

    Science.gov (United States)

    Rapaport, M.

    1998-07-01

    The central overlap problem in astrometry has been revisited in the recent last years by Eichhorn (1988) who explicitly inverted the matrix of a constrained least squares problem. In this paper, the general explicit solution of the unconstrained central overlap problem is given. We also give the explicit solution for an other set of constraints; this result is a confirmation of a conjecture expressed by Eichhorn (1988). We also consider the use of iterative methods to solve the central overlap problem. A surprising result is obtained when the classical Gauss Seidel method is used; the iterations converge immediately to the general solution of the equations; we explain this property writing the central overlap problem in a new set of variables.

  2. Precise Absolute Astrometry from the VLBA Imaging and Polarimetry Survey at 5 GHz

    Science.gov (United States)

    Petrov, L.; Taylor, G. B.

    2011-01-01

    We present accurate positions for 857 sources derived from the astrometric analysis of 16 eleven-hour experiments from the Very Long Baseline Array imaging and polarimetry survey at 5 GHz (VIPS). Among the observed sources, positions of 430 objects were not previously determined at milliarcsecond-level accuracy. For 95% of the sources the uncertainty of their positions ranges from 0.3 to 0.9 mas, with a median value of 0.5 mas. This estimate of accuracy is substantiated by the comparison of positions of 386 sources that were previously observed in astrometric programs simultaneously at 2.3/8.6 GHz. Surprisingly, the ionosphere contribution to group delay was adequately modeled with the use of the total electron content maps derived from GPS observations and only marginally affected estimates of source coordinates.

  3. Taking the Measure of the Universe: Precision Astrometry with SIM Planetquest (Preprint)

    National Research Council Canada - National Science Library

    Unwin, Stephen C; Shao, Michael; Tanner, Angelle M; Allen, Ronald J; Beichman, Charles A; Boboltz, David; Catanzarite, Joseph H; Chaboyer, Brian C; Ciardi, David R; Edberg, Stephen J

    2006-01-01

    ... = 20, and differential accuracy of 0.6 microarchsecond on bright targets. The science topics are drawn primarily from the Team Key Projects, selected in 2000, for the Space Interferometry Mission PlanetQuest (SIM PlanetQuest...

  4. PRECISE ABSOLUTE ASTROMETRY FROM THE VLBA IMAGING AND POLARIMETRY SURVEY AT 5 GHz

    International Nuclear Information System (INIS)

    Petrov, L.; Taylor, G. B.

    2011-01-01

    We present accurate positions for 857 sources derived from the astrometric analysis of 16 eleven-hour experiments from the Very Long Baseline Array imaging and polarimetry survey at 5 GHz (VIPS). Among the observed sources, positions of 430 objects were not previously determined at milliarcsecond-level accuracy. For 95% of the sources the uncertainty of their positions ranges from 0.3 to 0.9 mas, with a median value of 0.5 mas. This estimate of accuracy is substantiated by the comparison of positions of 386 sources that were previously observed in astrometric programs simultaneously at 2.3/8.6 GHz. Surprisingly, the ionosphere contribution to group delay was adequately modeled with the use of the total electron content maps derived from GPS observations and only marginally affected estimates of source coordinates.

  5. Taking the Measure of the Universe: Precision Astrometry with SIM Planetquest (Preprint)

    Science.gov (United States)

    2006-10-09

    streams, and § 11 explains how astro- metric microlensing provides insight into the mass spec- trum of dark bodies in the Galaxy. § 12 and 13 cover...condensates, and quark matter) can reproduce this mass for a large range of radii (Lattimer & Prakash 2004). However, more recently, there are indications...diameter, repre- sented by the dark circle in the center, was measured with the VLTI while the circumstellar SiO masers were imaged concurrently with

  6. International VLBI Service for Geodesy and Astrometry: General Meeting Proceedings

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

    2002-01-01

    This volume contains the proceedings of the second General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Tsukuba, Japan, February 4-7, 2002. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2002. The key-note of the second GM was prospectives for the future, in keeping with the re-organization of the IAG around the motivation of geodesy as 'an old science with a dynamic future' and noting that providing reference frames for Earth system science that are consistent over decades on the highest accuracy level will provide a challenging role for IVS. The goal of the meeting was to provide an interesting and informative program for a wide cross section of IVS members, including station operators, program managers, and analysts. This volume contains 72 papers and five abstracts of papers presented at the GM. The volume also includes reports about three splinter meetings held in conjunction with the GM: a mini-TOW (Technical Operations Workshop), the third IVS Analysis Workshop and a meeting of the analysis working group on geophysical modeling.

  7. CosmoQuest Transient Tracker: Opensource Photometry & Astrometry software

    Science.gov (United States)

    Myers, Joseph L.; Lehan, Cory; Gay, Pamela; Richardson, Matthew; CosmoQuest Team

    2018-01-01

    CosmoQuest is moving from online citizen science, to observational astronomy with the creation of Transient Trackers. This open source software is designed to identify asteroids and other transient/variable objects in image sets. Transient Tracker’s features in final form will include: astrometric and photometric solutions, identification of moving/transient objects, identification of variable objects, and lightcurve analysis. In this poster we present our initial, v0.1 release and seek community input.This software builds on the existing NIH funded ImageJ libraries. Creation of this suite of opensource image manipulation routines is lead by Wayne Rasband and is released primarily under the MIT license. In this release, we are building on these libraries to add source identification for point / point-like sources, and to do astrometry. Our materials released under the Apache 2.0 license on github (http://github.com/CosmoQuestTeam) and documentation can be found at http://cosmoquest.org/TransientTracker.

  8. International VLBI Service for Geodesy and Astrometry 2000 Annual Report

    Science.gov (United States)

    Vandenberg, N. R. (Editor); Baver, K. D. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    This volume of reports is the 2000 Annual Report of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS). The individual reports were contributed by VLBI groups in the international geodetic and astrometric community who constitute the permanent components of IVS. The IVS 2000 Annual Report documents the work of the IVS components for the period March 1, 1999 (the official inauguration date of IVS) through December 31, 2000. The reports document changes, activities, and progress of the IVS. The entire contents of this Annual Report also appear on the IVS web site at http://ivscc.gsfc.nasa.gov/publications/ar2000. This book and the web site are organized as follows: (1) The first section contains general information about IVS, a map showing the location of the components, information about the Directing Board members, and the report of the IVS Chair; (2) The second section of Special Reports contains a status report of the IVS Working Group on GPS phase center mapping, a reproduction of the resolution making IVS a Service of the International Astronomical Union (IAU), and a reprint of the VLBI Standard Interface (VSI); (3) The next seven sections hold the component reports from the Coordinators, Network Stations, Operation Centers, Correlators, Data Centers, Analysis Centers, and Technology Development Centers; and (4) The last section includes reference information about IVS: the Terms of Reference, the lists of Member and Affiliated organizations, the IVS Associate Member list, a complete list of IVS components, the list of institutions contributing to this report, and a list of acronyms. The 2000 Annual Report demonstrates the vitality of the IVS and the outstanding progress we have made during our first 22 months.

  9. Recent Radar Astrometry of Asteroid 2004 MN4

    Science.gov (United States)

    Giorgini, J. D.; Benner, L. A. M.; Nolan, M. C.; Ostro, S. J.

    2005-05-01

    Arecibo (2380-MHz) delay-Doppler radar astrometry obtained in late January of 2005 significantly corrected 2004 MN4's orbit. Doppler-shifted echoes were acquired 4.8-sigma away from the predicted frequency on Jan 27, while range to the object on Jan 29 was found to be 747 km (2.8-sigma) closer to Earth than the pre-radar orbit solution predicted. Incorporation of these radar measurements into least-squares orbit solution #82 resulted in a new predicted Earth encounter on 2029-Apr-13 of 36000 +/- 9900 km (3-sigma formal uncertainties), or 5.6 +/- 1.6 Earth radii, from Earth's center. This is inside geosynchronous orbit and 27700 km (4.3 Earth radii) closer to Earth than predicted by the pre-radar ephemeris -- a 5-sigma change compared to the pre-radar orbit solution, illustrating the problematic nature of prediction and statistical analysis when only single-apparition optical data-sets are available. The current data-set does not permit reliable trajectory propagation to encounters later than 2029; this may not be possible until data from 2012-2013 are available. The corrected nominal approach distance in 2029 is approximately twice the classical Roche limit and closer than any known past or future approach by a natural object larger than 10 m, other than those detected after already impacting the Earth or it's atmosphere. Such close approaches by objects as large as 2004 MN4 (D ≳ 0.3 km) are currently thought to occur at ≳ 1000-year intervals on average. 2004 MN4 is expected to reach 3rd magnitude for observers in Europe, western Asia, and Africa, and thus be visible to the unaided eye. The asteroid's disk will be 2-4 arcseconds across and potentially resolvable with small ground-based telescopes.

  10. Precision manufacturing

    CERN Document Server

    Dornfeld, David

    2008-01-01

    Today there is a high demand for high-precision products. The manufacturing processes are now highly sophisticated and derive from a specialized genre called precision engineering. Precision Manufacturing provides an introduction to precision engineering and manufacturing with an emphasis on the design and performance of precision machines and machine tools, metrology, tooling elements, machine structures, sources of error, precision machining processes and precision process planning. As well as discussing the critical role precision machine design for manufacturing has had in technological developments over the last few hundred years. In addition, the influence of sustainable manufacturing requirements in precision processes is introduced. Drawing upon years of practical experience and using numerous examples and illustrative applications, David Dornfeld and Dae-Eun Lee cover precision manufacturing as it applies to: The importance of measurement and metrology in the context of Precision Manufacturing. Th...

  11. ASTROMETRY AND RADIAL VELOCITIES OF THE PLANET HOST M DWARF GJ 317: NEW TRIGONOMETRIC DISTANCE, METALLICITY, AND UPPER LIMIT TO THE MASS OF GJ 317b

    International Nuclear Information System (INIS)

    Anglada-Escudé, Guillem; Boss, Alan P.; Weinberger, Alycia J.; Butler, R. Paul; Thompson, Ian B.; Vogt, Steven S.; Rivera, Eugenio J.

    2012-01-01

    We have obtained precision astrometry of the planet host M dwarf GJ 317 in the framework of the Carnegie Astrometric Planet Search project. The new astrometric measurements give a distance determination of 15.3 pc, 65% further than previous estimates. The resulting absolute magnitudes suggest that it is metal-rich and more massive than previously assumed. This result strengthens the correlation between high metallicity and the presence of gas giants around low-mass stars. At 15.3 pc, the minimal astrometric amplitude for planet candidate GJ 317b is 0.3 mas (edge-on orbit), just below our astrometric sensitivity. However, given the relatively large number of observations and good astrometric precision, a Bayesian Monte Carlo Markov Chain analysis indicates that the mass of planet b has to be smaller than twice the minimum mass with a 99% confidence level, with a most likely value of 2.5 M Jup . Additional radial velocity (RV) measurements obtained with Keck by the Lick-Carnegie Planet search program confirm the presence of an additional very long period planet candidate, with a period of 20 years or more. Even though such an object will imprint a large astrometric wobble on the star, its curvature is yet not evident in the astrometry. Given high metallicity, and the trend indicating that multiple systems are rich in low-mass companions, this system is likely to host additional low-mass planets in its habitable zone that can be readily detected with state-of-the-art optical and near-infrared RV measurements.

  12. ASTROMETRY AND RADIAL VELOCITIES OF THE PLANET HOST M DWARF GJ 317: NEW TRIGONOMETRIC DISTANCE, METALLICITY, AND UPPER LIMIT TO THE MASS OF GJ 317b

    Energy Technology Data Exchange (ETDEWEB)

    Anglada-Escude, Guillem; Boss, Alan P.; Weinberger, Alycia J.; Butler, R. Paul [Department of Terrestrial Magnetism, Carnegie Institution for Science, 5241 Broad Branch Road NW, Washington, DC 20015 (United States); Thompson, Ian B. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Vogt, Steven S.; Rivera, Eugenio J., E-mail: anglada@dtm.ciw.edu [UCO/Lick Observatory, University of California, Santa Cruz, CA 95064 (United States)

    2012-02-10

    We have obtained precision astrometry of the planet host M dwarf GJ 317 in the framework of the Carnegie Astrometric Planet Search project. The new astrometric measurements give a distance determination of 15.3 pc, 65% further than previous estimates. The resulting absolute magnitudes suggest that it is metal-rich and more massive than previously assumed. This result strengthens the correlation between high metallicity and the presence of gas giants around low-mass stars. At 15.3 pc, the minimal astrometric amplitude for planet candidate GJ 317b is 0.3 mas (edge-on orbit), just below our astrometric sensitivity. However, given the relatively large number of observations and good astrometric precision, a Bayesian Monte Carlo Markov Chain analysis indicates that the mass of planet b has to be smaller than twice the minimum mass with a 99% confidence level, with a most likely value of 2.5 M{sub Jup}. Additional radial velocity (RV) measurements obtained with Keck by the Lick-Carnegie Planet search program confirm the presence of an additional very long period planet candidate, with a period of 20 years or more. Even though such an object will imprint a large astrometric wobble on the star, its curvature is yet not evident in the astrometry. Given high metallicity, and the trend indicating that multiple systems are rich in low-mass companions, this system is likely to host additional low-mass planets in its habitable zone that can be readily detected with state-of-the-art optical and near-infrared RV measurements.

  13. Gaia Data Release 1 Open cluster astrometry: performance, limitations, and future prospects

    Czech Academy of Sciences Publication Activity Database

    van Leeuwen, F.; Vallenari, A.; Jordi, C.; Lindegren, L.; Bastian, U.; Prusti, T.; de Bruijne, J.H.J.; Brown, A.G.A.; Babusiaux, C.; Bailer-Jones, C.A.L.; Fuchs, Jan; Koubský, Pavel; Votruba, Viktor

    2017-01-01

    Roč. 601, May (2017), A19/1-A19/65 E-ISSN 1432-0746 R&D Projects: GA MŠk(CZ) LG15010 Grant - others:ESA(XE) ESA-PECS project No. 98058 Institutional support: RVO:67985815 Keywords : astrometry * open clusters and associations * proper motion and parallax Subject RIV: BN - Astronomy , Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 5.014, year: 2016

  14. Gaia Data Release 1. Open cluster astrometry: performance, limitations, and future prospects

    OpenAIRE

    Gaia Collaboration; van Leeuwen, F.; Vallenari, A.; Jordi, C.; Lindegren, L.; Bastian, U.; Prusti, T.; de Bruijne, J. H. J.; Brown, A. G. A.; Babusiaux, C.; Bailer-Jones, C. A. L.; Biermann, M.; Evans, D. W.; Eyer, L.; Jansen, F.

    2017-01-01

    Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). \\ud Aims. In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, which involve astrometry collected by Gaia during the initial 14 months of science operation, we compared them wi...

  15. Results of the astrometry and direct imaging testbed for exoplanet detection

    Science.gov (United States)

    Bendek, Eduardo A.; Belikov, Ruslan; Pluzhnik, Eugene; Guyon, Olivier; Milster, Thomas; Johnson, Lee; Finan, Emily; Knight, Justin; Rodack, Alexander

    2017-09-01

    Measuring masses of long-period planets around F, G, and K stars is necessary to characterize exoplanets and assess their habitability. Imaging stellar astrometry offers a unique opportunity to solve radial velocity system inclination ambiguity and determine exoplanet masses. The main limiting factor in sparse-field astrometry, besides photon noise, is the non-systematic dynamic distortions that arise from perturbations in the optical train. Even space optics suffer from dynamic distortions in the optical system at the sub-μas level. To overcome this limitation we propose a diffractive pupil that uses an array of dots on the primary mirror creating polychromatic diffraction spikes in the focal plane, which are used to calibrate the distortions in the optical system. By combining this technology with a high-performance coronagraph, measurements of planetary systems orbits and masses can be obtained faster and more accurately than by applying traditional techniques separately. In this paper, we present the results of the combined astrometry and and highcontrast imaging experiments performed at NASA Ames Research Center as part of a Technology Development for Exoplanet Missions program. We demonstrated 2.38x10-5 λ/D astrometric accuracy per axis and 1.72x10-7 raw contrast from 1.6 to 4.5 λ/D. In addition, using a simple average subtraction post-processing we demonstrated no contamination of the coronagraph field down to 4.79x10-9 raw contrast.

  16. Using Astrometrica to Teach an Introduction to Asteroid and Comet Astrometry

    Science.gov (United States)

    Durig, Douglas T.

    2007-05-01

    We have organized a Consortium for Astronomy Research and Teaching (CART) with several small colleges and universities from the Appalachian Colleges Association (ACA). In 2006 we received a small grant from the ACA Teaching and Learning Conference to develop laboratory exercises using the on-line telescopes of the Cordell-Lorenz Observatory of The University of the South in Sewanee, TN. We have completed and tested the first two, Asteroid Astrometry and Comet Astronomy and Angular Size. We are continuing to develop several more on the HR Diagram, Cataclysmic Variables and Short Period Variable Stars. We had unknown new asteroids in the field of view the first four times we performed the Asteroid Astrometry exercise but, unfortunately, none of the students recognized the new objects. However, they were more motivated to perform the exercise because of the opportunity to discover the new objects and they performed better on the review questions than students doing a comparable virtual exercise. Both of the astrometry exercises use the Astrometrica program developed by Herbert Raab and provide an introduction to the use and applications of this very functional shareware program. The program is available for free to educators.

  17. Why precision?

    Energy Technology Data Exchange (ETDEWEB)

    Bluemlein, Johannes

    2012-05-15

    Precision measurements together with exact theoretical calculations have led to steady progress in fundamental physics. A brief survey is given on recent developments and current achievements in the field of perturbative precision calculations in the Standard Model of the Elementary Particles and their application in current high energy collider data analyses.

  18. Why precision?

    International Nuclear Information System (INIS)

    Bluemlein, Johannes

    2012-05-01

    Precision measurements together with exact theoretical calculations have led to steady progress in fundamental physics. A brief survey is given on recent developments and current achievements in the field of perturbative precision calculations in the Standard Model of the Elementary Particles and their application in current high energy collider data analyses.

  19. HUBBLE SPACE TELESCOPE ASTROMETRY OF THE PROCYON SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Bond, Howard E. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Gilliland, Ronald L.; Kozhurina-Platais, Vera; Nelan, Edmund P. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Schaefer, Gail H. [The CHARA Array of Georgia State University, Mount Wilson Observatory, Mount Wilson, CA 91023 (United States); Demarque, Pierre; Girard, Terrence M. [Department of Astronomy, Yale University, Box 208101, New Haven, CT 06520 (United States); Holberg, Jay B. [Lunar and Planetary Laboratory, University of Arizona, 1541 E. University Blvd., Tucson, AZ 85721 (United States); Gudehus, Donald [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30303 (United States); Mason, Brian D. [U.S. Naval Observatory, 3450 Massachusetts Ave., Washington, DC 20392 (United States); Burleigh, Matthew R.; Barstow, Martin A., E-mail: heb11@psu.edu [Department of Physics and Astronomy, University of Leicester, Leicester LE1 7RH (United Kingdom)

    2015-11-10

    The nearby star Procyon is a visual binary containing the F5 IV-V subgiant Procyon A, orbited in a 40.84-year period by the faint DQZ white dwarf (WD) Procyon B. Using images obtained over two decades with the Hubble Space Telescope, and historical measurements back to the 19th century, we have determined precise orbital elements. Combined with measurements of the parallax and the motion of the A component, these elements yield dynamical masses of 1.478 ± 0.012 M{sub ⊙} and 0.592 ± 0.006 M{sub ⊙} for A and B, respectively. The mass of Procyon A agrees well with theoretical predictions based on asteroseismology and its temperature and luminosity. Use of a standard core-overshoot model agrees best for a surprisingly high amount of core overshoot. Under these modeling assumptions, Procyon A’s age is ∼2.7 Gyr. Procyon B’s location in the H-R diagram is in excellent agreement with theoretical cooling tracks for WDs of its dynamical mass. Its position in the mass–radius plane is also consistent with theory, assuming a carbon–oxygen core and a helium-dominated atmosphere. Its progenitor’s mass was 1.9–2.2 M{sub ⊙}, depending on its amount of core overshoot. Several astrophysical puzzles remain. In the progenitor system, the stars at periastron were separated by only ∼5 AU, which might have led to tidal interactions and even mass transfer; yet there is no direct evidence that these have occurred. Moreover the orbital eccentricity has remained high (∼0.40). The mass of Procyon B is somewhat lower than anticipated from the initial-to-final-mass relation seen in open clusters. The presence of heavy elements in its atmosphere requires ongoing accretion, but the place of origin is uncertain.

  20. Hubble Space Telescope Astrometry of the Procyon System

    Science.gov (United States)

    Bond, Howard E.; Gilliland, Ronald L.; Schaefer, Gail H.; Demarque, Pierre; Girard, Terrence M.; Holberg, Jay B.; Gudehus, Donald; Mason, Brian D.; Kozhurina-Platais, Vera; Burleigh, Matthew R.

    2015-01-01

    The nearby star Procyon is a visual binary containing the F5 IV-V subgiant Procyon A, orbited in a 40.84-year period by the faint DQZ white dwarf (WD) Procyon B. Using images obtained over two decades with the Hubble Space Telescope, and historical measurements back to the 19th century, we have determined precise orbital elements. Combined with measurements of the parallax and the motion of the A component, these elements yield dynamical masses of 1.478 plus or minus 0.012M and 0.592 plus or minus 0.006M for A and B, respectively. The mass of Procyon A agrees well with theoretical predictions based on asteroseismology and its temperature and luminosity. Use of a standard core-overshoot model agrees best for a surprisingly high amount of core overshoot. Under these modeling assumptions, Procyon A's age is approximately 2.7 Gyr. Procyon B's location in the H-R diagram is in excellent agreement with theoretical cooling tracks for WDs of its dynamical mass. Its position in the mass-radius plane is also consistent with theory, assuming a carbon-oxygen core and a helium-dominated atmosphere. Its progenitor's mass was 1.9-2.2M, depending on its amount of core overshoot. Several astrophysical puzzles remain. In the progenitor system, the stars at periastron were separated by only approximately AU, which might have led to tidal interactions and even mass transfer; yet there is no direct evidence that these have occurred. Moreover the orbital eccentricity has remained high (approximately 0.40). The mass of Procyon B is somewhat lower than anticipated from the initial-to-final-mass relation seen in open clusters. The presence of heavy elements in its atmosphere requires ongoing accretion, but the place of origin is uncertain.

  1. Microlensing and Its Degeneracy Breakers: Parallax, Finite Source, High-Resolution Imaging, and Astrometry

    Directory of Open Access Journals (Sweden)

    Chien-Hsiu Lee

    2017-07-01

    Full Text Available First proposed by Paczynski in 1986, microlensing has been instrumental in the search for compact dark matter as well as discovery and characterization of exoplanets. In this article, we provide a brief history of microlensing, especially on the discoveries of compact objects and exoplanets. We then review the basics of microlensing and how astrometry can help break the degeneracy, providing a more robust determination of the nature of the microlensing events. We also outline prospects that will be made by on-going and forth-coming experiments/observatories.

  2. Dynamical analysis of nearby clusters. Automated astrometry from the ground: precision proper motions over a wide field

    Science.gov (United States)

    Bouy, H.; Bertin, E.; Moraux, E.; Cuillandre, J.-C.; Bouvier, J.; Barrado, D.; Solano, E.; Bayo, A.

    2013-06-01

    Context. The kinematic properties of the different classes of objects in a given association hold important clues about the history of its members, and offer a unique opportunity to test the predictions of the various models of stellar formation and evolution. Aims: DANCe (standing for dynamical analysis of nearby clusters) is a survey program aimed at deriving a comprehensive and homogeneous census of the stellar and substellar content of a number of nearby (history, and the presence of reference extragalactic sources for the anchoring onto the ICRS. Based on observations obtained with MegaPrime/MegaCam, a joint project of CFHT and CEA/DAPNIA, at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council (NRC) of Canada, the Institut National des Science de l'Univers of the Centre National de la Recherche Scientifique (CNRS) of France, and the University of Hawaii.

  3. Precision translator

    Science.gov (United States)

    Reedy, Robert P.; Crawford, Daniel W.

    1984-01-01

    A precision translator for focusing a beam of light on the end of a glass fiber which includes two turning fork-like members rigidly connected to each other. These members have two prongs each with its separation adjusted by a screw, thereby adjusting the orthogonal positioning of a glass fiber attached to one of the members. This translator is made of simple parts with capability to keep adjustment even in condition of rough handling.

  4. Precision Cosmology

    Science.gov (United States)

    Jones, Bernard J. T.

    2017-04-01

    Preface; Notation and conventions; Part I. 100 Years of Cosmology: 1. Emerging cosmology; 2. The cosmic expansion; 3. The cosmic microwave background; 4. Recent cosmology; Part II. Newtonian Cosmology: 5. Newtonian cosmology; 6. Dark energy cosmological models; 7. The early universe; 8. The inhomogeneous universe; 9. The inflationary universe; Part III. Relativistic Cosmology: 10. Minkowski space; 11. The energy momentum tensor; 12. General relativity; 13. Space-time geometry and calculus; 14. The Einstein field equations; 15. Solutions of the Einstein equations; 16. The Robertson-Walker solution; 17. Congruences, curvature and Raychaudhuri; 18. Observing and measuring the universe; Part IV. The Physics of Matter and Radiation: 19. Physics of the CMB radiation; 20. Recombination of the primeval plasma; 21. CMB polarisation; 22. CMB anisotropy; Part V. Precision Tools for Precision Cosmology: 23. Likelihood; 24. Frequentist hypothesis testing; 25. Statistical inference: Bayesian; 26. CMB data processing; 27. Parametrising the universe; 28. Precision cosmology; 29. Epilogue; Appendix A. SI, CGS and Planck units; Appendix B. Magnitudes and distances; Appendix C. Representing vectors and tensors; Appendix D. The electromagnetic field; Appendix E. Statistical distributions; Appendix F. Functions on a sphere; Appendix G. Acknowledgements; References; Index.

  5. The jet of the Low Luminosity AGN of M81

    Directory of Open Access Journals (Sweden)

    Alberdi A.

    2013-12-01

    Full Text Available In this contribution, we summarize our main results of a big campaign of global VLBI observations of the AGN in M81 (M81* phase-referenced to the radio supernova SN 1993J. Thanks to the precise multi-epoch and multi-frequency astrometry, we have determined the normalized core-shift of the relativistic jet of M81* and estimated both the magnetic field and the particle density at the jet base. We have also found evidence of jet precession in M81* coming from the systematic time evolution of the jet orientation correlated with changes in the overall flux density.

  6. REFERENCE-LESS DETECTION, ASTROMETRY, AND PHOTOMETRY OF FAINT COMPANIONS WITH ADAPTIVE OPTICS

    International Nuclear Information System (INIS)

    Gladysz, Szymon; Christou, Julian C.

    2009-01-01

    We propose a complete framework for the detection, astrometry, and photometry of faint companions from a sequence of adaptive optics (AO) corrected short exposures. The algorithms exploit the difference in statistics between the on-axis and off-axis intensity of the AO point-spread function (PSF) to differentiate real sources from speckles. We validate the new approach and illustrate its performance using moderate Strehl ratio data obtained with the natural guide star AO system on the Lick Observatory's 3 m Shane Telescope. We obtain almost a 2 mag gain in achievable contrast by using our detection method compared to 5σ detectability in long exposures. We also present a first guide to expected accuracy of differential photometry and astrometry with the new techniques. Our approach performs better than PSF-fitting in general and especially so for close companions, which are located within the uncompensated seeing (speckle) halo. All three proposed algorithms are self-calibrating, i.e., they do not require observation of a calibration star. One of the advantages of this approach is improved observing efficiency.

  7. THE ARECIBO METHANOL MASER GALACTIC PLANE SURVEY. IV. ACCURATE ASTROMETRY AND SOURCE MORPHOLOGIES

    International Nuclear Information System (INIS)

    Pandian, J. D.; Momjian, E.; Xu, Y.; Menten, K. M.; Goldsmith, P. F.

    2011-01-01

    We present accurate absolute astrometry of 6.7 GHz methanol masers detected in the Arecibo Methanol Maser Galactic Plane Survey using MERLIN and the Expanded Very Large Array (EVLA). We estimate the absolute astrometry to be accurate to better than 15 and 80 mas for the MERLIN and EVLA observations, respectively. We also derive the morphologies of the maser emission distributions for sources stronger than ∼1 Jy. The median spatial extent along the major axis of the regions showing maser emission is ∼775 AU. We find a majority of methanol maser morphologies to be complex with some sources previously determined to have regular morphologies in fact being embedded within larger structures. This suggests that some maser spots do not have a compact core, which leads to them being resolved in high angular resolution observations. This also casts doubt on interpretations of the origin of methanol maser emission solely based on source morphologies. We also investigate the association of methanol masers with mid-infrared emission and find very close correspondence between methanol masers and 24 μm point sources. This adds further credence to theoretical models that predict methanol masers to be pumped by warm dust emission and firmly reinforces the finding that Class II methanol masers are unambiguous tracers of embedded high-mass protostars.

  8. Precision Airdrop (Largage de precision)

    Science.gov (United States)

    2005-12-01

    NAVIGATION TO A PRECISION AIRDROP OVERVIEW RTO-AG-300-V24 2 - 9 the point from various compass headings. As the tests are conducted, the resultant...rate. This approach avoids including a magnetic compass for the heading reference, which has difficulties due to local changes in the magnetic field...Scientifica della Difesa ROYAUME-UNI Via XX Settembre 123 Dstl Knowledge Services ESPAGNE 00187 Roma Information Centre, Building 247 SDG TECEN / DGAM

  9. Internet Astrometry

    Science.gov (United States)

    Caballero, Rafael; Argyle, R. W.

    Amateur astronomers can carry out scientific research in many different ways. Some activities require expensive telescopes, cameras, and often access to dark skies. But those who live in highly polluted areas, or do not have access to very specialized equipment, still have many possibilities; amongst which is using the online resources available from the internet. In this chapter we explore Aladin, Simbad, and VizieR, three resources created and maintained by the Centre de Données astronomiques de Strasbourg (CDS). Although these applications are intended for professional astronomers, they are also freely available for amateurs. They allow us to find and measure old neglected difficult pairs, discover new double stars, and in general have a better understanding of those tiny pairs of points of light that we love to observe, photograph and measure.

  10. International VLBI Service for Geodesy and Astrometry: 2000 General Meeting Proceedings

    Science.gov (United States)

    Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

    2000-01-01

    This volume is the proceedings of the first General Meeting of the International Very Long Base Interferometry (VLBI) Service for Geodesy and Astrometry (IVS), held in Koetzting, Germany, February 21-24, 2000. The content of this volume also appears on the IVS web site at: http://ivscc.gsfc.nasa.gov/publications/gm2000. The goal of the program committee for the General Meeting was to provide an interesting and informative program for a wide cross section of IVS members, including station operators, program managers, and analysts. The program included reports, tutorials, invited and contributed papers, and poster presentations. The tutorial papers should be particularly useful references because each one provides an overview and introduction to a topic relevant to VLBI.

  11. Proceedings of the Sixth General Meeting of the International VLBI Service for Geodesy and Astrometry

    Science.gov (United States)

    Behrend, Dirk (Editor); Baver, Karen D. (Editor)

    2010-01-01

    This volume is the proceedings of the sixth General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Hobart, Tasmania, Australia, February 7-13, 2010. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2010. The keynote of the sixth GM was the new perspectives of the next generation VLBI system under the theme "VLBI2010: From Vision to Reality". The goal of the meeting was to provide an interesting and informative program for a wide cross-section of IVS members, including station operators, program managers, and analysts. This volume contains 88 papers. All papers were edited by the editors for usage of the English language, form, and minor content-related issues.

  12. BAM/DASS: Data Analysis Software for Sub-Microarcsecond Astrometry Device

    Science.gov (United States)

    Gardiol, D.; Bonino, D.; Lattanzi, M. G.; Riva, A.; Russo, F.

    2010-12-01

    The INAF - Osservatorio Astronomico di Torino is part of the Data Processing and Analysis Consortium (DPAC) for Gaia, a cornerstone mission of the European Space Agency. Gaia will perform global astrometry by means of two telescopes looking at the sky along two different lines of sight oriented at a fixed angle, also called basic angle. Knowledge of the basic angle fluctuations at the sub-microarcsecond level over periods of the order of the minute is crucial to reach the mission goals. A specific device, the Basic Angle Monitoring, will be dedicated to this purpose. We present here the software system we are developing to analyze the BAM data and recover the basic angle variations. This tool is integrated into the whole DPAC data analysis software.

  13. VizieR Online Data Catalog: Accurate astrometry & RVs of 4 multiple systems (Tokovinin+, 2017)

    Science.gov (United States)

    Tokovinin, A.; Latham, D. W.

    2017-10-01

    The outer subsystems are classical visual binaries. Historic micrometric measurements and modern speckle interferometric data have been obtained from the WDS database on our request. Additionally, we secured new speckle astrometry and relative photometry of two systems at the 4.1m SOAR telescope. Published radial velocities (RVs) are used here together with the new data. The RVs were measured with the CfA Digital Speedometers, initially using the 1.5m Wyeth Reflector at the Oak Ridge Observatory in the town of Harvard, Massachusetts, and subsequently with the 1.5m Tillinghast Reflector at the Whipple Observatory on Mount Hopkins, Arizona. Starting in 2009, the new fiber-fed Tillinghast Reflector Echelle Spectrograph (TRES) was used. The spectral resolution was 44000 for all three spectrographs. Two objects, HIP 101955 and 103987, were observed in 2015 with the CHIRON echelle spectrograph at the 1.5m telescope at CTIO with a spectral resolution of 80000. (4 data files).

  14. WCSTools 3.0: More Tools for Image Astrometry and Catalog Searching

    Science.gov (United States)

    Mink, Douglas J.

    For five years, WCSTools has provided image astrometry for astronomers who need accurate positions for objects they wish to observe. Other functions have been added and improved since the package was first released. Support has been added for new catalogs, such as the GSC-ACT, 2MASS Point Source Catalog, and GSC II, as they have been published. A simple command line interface can search any supported catalog, returning information in several standard formats, whether the catalog is on a local disk or searchable over the World Wide Web. The catalog searching routine can be located on either end (or both ends!) of such a web connection, and the output from one catalog search can be used as the input to another search.

  15. Radar Astrometry of Asteroid 99942 (2004 MN4): Predicting the 2029 Earth Encounter and Beyond

    Science.gov (United States)

    Giorgini, J. D.; Benner, L. A. M.; Nolan, M. C.; Ostro, S. J.

    2005-08-01

    Asteroid 2004 MN4 is expected to pass 4.6 (+/- 1.6) Earth-radii above the surface of the Earth on 2029-Apr-13. Such close approaches by objects as large as 2004 MN4 (D ≳ 0.3 km) are thought to occur at ≳ 1000-year intervals on average. 2004 MN4 is expected to reach 3rd magnitude and thus be visible to the unaided eye. With a disk 2-4 arcseconds across, it may be resolved by ground-based telescopes. Arecibo (2380-MHz) delay-Doppler radar astrometry, obtained in late January 2005, significantly corrected 2004 MN4's orbit by revealing a 1.4 arcsecond bias in pre-discovery optical measurements. Doppler-shifted echoes were acquired 4.8σ (176.4 mm/s) away from the predicted frequency on Jan 27. Range on Jan 29 was found to be 747 km (2.8σ ) closer to Earth than the pre-radar orbit predicted. Incorporation of these delay-Doppler measurements into a new weighted least-squares orbit solution moved the 2029-Apr-13 encounter prediction 5σ closer to the Earth, illustrating the problematic nature of prediction and statistical analysis with single-apparition optical data-sets. Without delay-Doppler data, the bias was not apparent, even when optical measurements spanned a full orbit period. The current combined data-set does not permit reliable trajectory propagation to encounters beyond 2029; Monte Carlo analysis shows that, by 2036, the 3σ confidence region wraps >300 degrees of heliocentric longitude around the Sun, with some sections of this statistical region experiencing low-probability encounters with the Earth in the 2030's, gravitationally scattering some possible trajectories inward to the orbit of Venus, or outward toward Mars. Future measurements from radar opportunities in August 2005 and May 2006 (SNR ≈5-10) have the potential to eliminate statistical encounters in the 2030's. Delay-Doppler astrometry from 2013 (SNR ≈30) should permit deterministic encounter prediction through 2070, shrinking the along-track uncertainty in 2036 by two orders of magnitude

  16. Vienna VLBI and Satellite Software (VieVS) for Geodesy and Astrometry

    Science.gov (United States)

    Böhm, Johannes; Böhm, Sigrid; Boisits, Janina; Girdiuk, Anastasiia; Gruber, Jakob; Hellerschmied, Andreas; Krásná, Hana; Landskron, Daniel; Madzak, Matthias; Mayer, David; McCallum, Jamie; McCallum, Lucia; Schartner, Matthias; Teke, Kamil

    2018-04-01

    The Vienna VLBI and Satellite Software (VieVS) is state-of-the-art Very Long Baseline Interferometry (VLBI) analysis software for geodesy and astrometry. VieVS has been developed at Technische Universität Wien (TU Wien) since 2008, where it is used for research purposes and for teaching space geodetic techniques. In the past decade, it has been successfully applied on Very Long Baseline Interferometry (VLBI) observations for the determination of celestial and terrestrial reference frames as well as for the estimation of celestial pole offsets, universal Time (UT1-UTC), and polar motion based on least-squares adjustment. Furthermore, VieVS is equipped with tools for scheduling and simulating VLBI observations to extragalactic radio sources as well as to satellites and spacecraft, features which proved to be very useful for a variety of applications. VieVS is now available as version 3.0 and we do provide the software to all interested persons and institutions. A wiki with more information about VieVS is available at http://vievswiki.geo.tuwien.ac.at/.

  17. Application of the Allan Variance to Time Series Analysis in Astrometry and Geodesy: A Review.

    Science.gov (United States)

    Malkin, Zinovy

    2016-04-01

    The Allan variance (AVAR) was introduced 50 years ago as a statistical tool for assessing the frequency standards deviations. For the past decades, AVAR has increasingly been used in geodesy and astrometry to assess the noise characteristics in geodetic and astrometric time series. A specific feature of astrometric and geodetic measurements, as compared with clock measurements, is that they are generally associated with uncertainties; thus, an appropriate weighting should be applied during data analysis. In addition, some physically connected scalar time series naturally form series of multidimensional vectors. For example, three station coordinates time series X, Y, and Z can be combined to analyze 3-D station position variations. The classical AVAR is not intended for processing unevenly weighted and/or multidimensional data. Therefore, AVAR modifications, namely weighted AVAR (WAVAR), multidimensional AVAR (MAVAR), and weighted multidimensional AVAR (WMAVAR), were introduced to overcome these deficiencies. In this paper, a brief review is given of the experience of using AVAR and its modifications in processing astrogeodetic time series.

  18. An Improved Technique for the Photometry and Astrometry of Faint Companions

    Science.gov (United States)

    Burke, Daniel; Gladysz, Szymon; Roberts, Lewis; Devaney, Nicholas; Dainty, Chris

    2009-07-01

    We propose a new approach to differential astrometry and photometry of faint companions in adaptive optics images. It is based on a prewhitening matched filter, also referred to in the literature as the Hotelling observer. We focus on cases where the signal of the companion is located within the bright halo of the parent star. Using real adaptive optics data from the 3 m Shane telescope at the Lick Observatory, we compare the performance of the Hotelling algorithm with other estimation algorithms currently used for the same problem. The real single-star data are used to generate artificial binary objects with a range of magnitude ratios. In most cases, the Hotelling observer gives significantly lower astrometric and photometric errors. In the case of high Strehl ratio (SR) data (SR ≈ 0.5), the differential photometry of a binary star with a Δm = 4.5 and a separation of 0.6″ is better than 0.1 mag a factor of 2 lower than the other algorithms considered.

  19. The solar neighborhood. XXXIV. A search for planets orbiting nearby M dwarfs using astrometry

    International Nuclear Information System (INIS)

    Lurie, John C.; Henry, Todd J.; Ianna, Philip A.; Jao, Wei-Chun; Quinn, Samuel N.; Winters, Jennifer G.; Koerner, David W.; Riedel, Adric R.; Subasavage, John P.

    2014-01-01

    Astrometric measurements are presented for seven nearby stars with previously detected planets: six M dwarfs (GJ 317, GJ 667C, GJ 581, GJ 849, GJ 876, and GJ 1214) and one K dwarf (BD-10 -3166). Measurements are also presented for six additional nearby M dwarfs without known planets, but which are more favorable to astrometric detections of low mass companions, as well as three binary systems for which we provide astrometric orbit solutions. Observations have baselines of 3 to 13 years, and were made as part of the RECONS long-term astrometry and photometry program at the CTIO/SMARTS 0.9 m telescope. We provide trigonometric parallaxes and proper motions for all 16 systems, and perform an extensive analysis of the astrometric residuals to determine the minimum detectable companion mass for the 12 M dwarfs not having close stellar secondaries. For the six M dwarfs with known planets, we are not sensitive to planets, but can rule out the presence of all but the least massive brown dwarfs at periods of 2–12 years. For the six more astrometrically favorable M dwarfs, we conclude that none have brown dwarf companions, and are sensitive to companions with masses as low as 1 M Jup for periods longer than two years. In particular, we conclude that Proxima Centauri has no Jovian companions at orbital periods of 2–12 years. These results complement previously published M dwarf planet occurrence rates by providing astrometrically determined upper mass limits on potential super-Jupiter companions at orbits of two years and longer. As part of a continuing survey, these results are consistent with the paucity of super-Jupiter and brown dwarf companions we find among the over 250 red dwarfs within 25 pc observed longer than five years in our astrometric program.

  20. The solar neighborhood. XXXIV. A search for planets orbiting nearby M dwarfs using astrometry

    Energy Technology Data Exchange (ETDEWEB)

    Lurie, John C. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Henry, Todd J.; Ianna, Philip A. [RECONS Institute, Chambersburg, PA 17201 (United States); Jao, Wei-Chun; Quinn, Samuel N.; Winters, Jennifer G. [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30302 (United States); Koerner, David W. [Department of Physics and Astronomy, Northern Arizona University, Flagstaff, AZ 86011 (United States); Riedel, Adric R. [Department of Astrophysics, American Museum of Natural History, New York, NY 10034 (United States); Subasavage, John P., E-mail: lurie@uw.edu [United States Naval Observatory, Flagstaff, AZ 86001 (United States)

    2014-11-01

    Astrometric measurements are presented for seven nearby stars with previously detected planets: six M dwarfs (GJ 317, GJ 667C, GJ 581, GJ 849, GJ 876, and GJ 1214) and one K dwarf (BD-10 -3166). Measurements are also presented for six additional nearby M dwarfs without known planets, but which are more favorable to astrometric detections of low mass companions, as well as three binary systems for which we provide astrometric orbit solutions. Observations have baselines of 3 to 13 years, and were made as part of the RECONS long-term astrometry and photometry program at the CTIO/SMARTS 0.9 m telescope. We provide trigonometric parallaxes and proper motions for all 16 systems, and perform an extensive analysis of the astrometric residuals to determine the minimum detectable companion mass for the 12 M dwarfs not having close stellar secondaries. For the six M dwarfs with known planets, we are not sensitive to planets, but can rule out the presence of all but the least massive brown dwarfs at periods of 2–12 years. For the six more astrometrically favorable M dwarfs, we conclude that none have brown dwarf companions, and are sensitive to companions with masses as low as 1 M{sub Jup} for periods longer than two years. In particular, we conclude that Proxima Centauri has no Jovian companions at orbital periods of 2–12 years. These results complement previously published M dwarf planet occurrence rates by providing astrometrically determined upper mass limits on potential super-Jupiter companions at orbits of two years and longer. As part of a continuing survey, these results are consistent with the paucity of super-Jupiter and brown dwarf companions we find among the over 250 red dwarfs within 25 pc observed longer than five years in our astrometric program.

  1. Near Infrared High Resolution Spectroscopy and Spectro-astrometry of Gas in Disks around Herbig Ae/Be Stars

    OpenAIRE

    Brittain, Sean D.; Najita, Joan R.; Carr, John S.

    2015-01-01

    In this review, we describe how high resolution near infrared spectroscopy and spectro-astrometry have been used to study the disks around Herbig~Ae/Be stars. We show how these tools can be used to identify signposts of planet formation and elucidate the mechanism by which Herbig Ae/Be stars accrete. We also highlight some of the artifacts that can complicate the interpretation of spectro-astrometric measurements and discuss best practices for mitigating these effects. We conclude with a brie...

  2. THE SYNERGY OF DIRECT IMAGING AND ASTROMETRY FOR ORBIT DETERMINATION OF EXO-EARTHS

    International Nuclear Information System (INIS)

    Shao, Michael; Catanzarite, Joseph; Pan Xiaopei

    2010-01-01

    The holy grail of exoplanet searches is an exo-Earth, an Earth mass planet in the habitable zone (HZ) around a nearby star. Mass is one of the most important characteristics of a planet and can only be measured by observing the motion of the star around the planet-star center of gravity. The planet's orbit can be measured either by imaging the planet at multiple epochs or by measuring the position of the star at multiple epochs by space-based astrometry. The measurement of an exoplanet's orbit by direct imaging is complicated by a number of factors. One is the inner working angle (IWA). A space coronagraph or interferometer imaging an exo-Earth can separate the light from the planet from the light from the star only when the star-planet separation is larger than the IWA. Second, the apparent brightness of a planet depends on the orbital phase. A single image of a planet cannot tell us whether the planet is in the HZ or distinguish whether it is an exo-Earth or a Neptune-mass planet. Third is the confusion that may arise from the presence of multiple planets. With two images of a multiple planet system, it is not possible to assign a dot to a planet based only on the photometry and color of the planet. Finally, the planet-star contrast must exceed a certain minimum value in order for the planet to be detected. The planet may be unobservable even when it is outside the IWA, such as when the bright side of the planet is facing away from us in a 'crescent' phase. In this paper we address the question: 'Can a prior astrometric mission that can identify which stars have Earth-like planets significantly improve the science yield of a mission to image exo-Earths?' In the case of the Occulting Ozone Observatory, a small external occulter mission that cannot measure spectra, we find that the occulter mission could confirm the orbits of ∼4 to ∼5 times as many exo-Earths if an astrometric mission preceded it to identify which stars had such planets. In the case of an

  3. Multi-epoch intranight optical monitoring of eight radio-quiet BL Lac candidates

    Science.gov (United States)

    Kumar, P.; Gopal-Krishna; Stalin, C. S.; Chand, H.; Srianand, R.; Petitjean, P.

    2017-10-01

    For a new sample of eight weak-line quasars (WLQs) we report a sensitive search in 20 intranight monitoring sessions, for blazar-like optical flux variations on hour-like and longer time-scale (day/month/year-like). The sample consists exclusively of the WLQs that are not radio-loud and either have been classified as 'radio-weak probable BL Lac candidates' and/or are known to have exhibited at least one episode of large, blazar-like optical variability. Whereas only a hint of intranight variability is seen for two of these WLQs, J104833.5+620305.0 (z = 0.219) and J133219.6+622715.9 (z = 3.15), statistically significant internight variability at a few per cent level is detected for three of the sources, including the radio-intermediate WLQ J133219.6+622715.9 (z = 3.15) and the well-known bona fide radio-quiet WLQs J121221.5+534128.0 (z = 3.10) and WLQ J153259.9-003944.1 (z = 4.62). In the rest frame, this variability is intraday and in the far-ultraviolet band. On the time-scale of a decade, we find for three of the WLQs large brightness changes, amounting to 1.655 ± 0.009, 0.163 ± 0.010 and 0.144 ± 0.018 mag, for J104833.5+620305.0, J123743.1+630144.9 and J232428.4+144324.4, respectively. Whereas the latter two are confirmed radio-quiet WLQs, the extragalactic nature of J104833.5+620305.0 remains to be well established, thanks to the absence of any feature(s) in its available optical spectra. This study forms a part of our ongoing campaign of intranight optical monitoring of radio-quiet WLQs, in order to improve the understanding of this enigmatic class of active galactic nuclei and to look among them for a possible tiny, elusive population of radio-quiet BL Lacs.

  4. Size and Shape of Chariklo from Multi-epoch Stellar Occultations

    Science.gov (United States)

    Leiva, R.; Sicardy, B.; Camargo, J. I. B.; Ortiz, J.-L.; Desmars, J.; Bérard, D.; Lellouch, E.; Meza, E.; Kervella, P.; Snodgrass, C.; Duffard, R.; Morales, N.; Gomes-Júnior, A. R.; Benedetti-Rossi, G.; Vieira-Martins, R.; Braga-Ribas, F.; Assafin, M.; Morgado, B. E.; Colas, F.; De Witt, C.; Sickafoose, A. A.; Breytenbach, H.; Dauvergne, J.-L.; Schoenau, P.; Maquet, L.; Bath, K.-L.; Bode, H.-J.; Cool, A.; Lade, B.; Kerr, S.; Herald, D.

    2017-10-01

    We use data from five stellar occultations observed between 2013 and 2016 to constrain Chariklo’s size and shape, and the ring reflectivity. We consider four possible models for Chariklo (sphere, Maclaurin spheroid, triaxial ellipsoid, and Jacobi ellipsoid), and we use a Bayesian approach to estimate the corresponding parameters. The spherical model has a radius R = 129 ± 3 km. The Maclaurin model has equatorial and polar radii a=b={143}-6+3 {km} and c={96}-4+14 {km}, respectively, with density {970}-180+300 {kg} {{{m}}}-3. The ellipsoidal model has semiaxes a={148}-4+6 {km}, b={132}-5+6 {km}, and c={102}-8+10 {km}. Finally, the Jacobi model has semiaxes a = 157 ± 4 km, b = 139 ± 4 km, and c = 86 ± 1 km, and density {796}-4+2 {kg} {{{m}}}-3. Depending on the model, we obtain topographic features of 6-11 km, typical of Saturn icy satellites with similar size and density. We constrain Chariklo’s geometric albedo between 3.1% (sphere) and 4.9% (ellipsoid), while the ring I/F reflectivity is less constrained between 0.6% (Jacobi) and 8.9% (sphere). The ellipsoid model explains both the optical light curve and the long-term photometry variation of the system, giving a plausible value for the geometric albedo of the ring particles of 10%-15%. The derived mass of Chariklo of 6-8 × 1018 kg places the rings close to 3:1 resonance between the ring mean motion and Chariklo’s rotation period. Based on observations obtained at the Southern Astrophysical Research (SOAR) telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the U.S. National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

  5. The newest precision measurement

    International Nuclear Information System (INIS)

    Lee, Jing Gu; Lee, Jong Dae

    1974-05-01

    This book introduces basic of precision measurement, measurement of length, limit gauge, measurement of angles, measurement of surface roughness, measurement of shapes and locations, measurement of outline, measurement of external and internal thread, gear testing, accuracy inspection of machine tools, three dimension coordinate measuring machine, digitalisation of precision measurement, automation of precision measurement, measurement of cutting tools, measurement using laser, and point of choosing length measuring instrument.

  6. Practical precision measurement

    International Nuclear Information System (INIS)

    Kwak, Ho Chan; Lee, Hui Jun

    1999-01-01

    This book introduces basic knowledge of precision measurement, measurement of length, precision measurement of minor diameter, measurement of angles, measurement of surface roughness, three dimensional measurement, measurement of locations and shapes, measurement of screw, gear testing, cutting tools testing, rolling bearing testing, and measurement of digitalisation. It covers height gauge, how to test surface roughness, measurement of plan and straightness, external and internal thread testing, gear tooth measurement, milling cutter, tab, rotation precision measurement, and optical transducer.

  7. [Precision and personalized medicine].

    Science.gov (United States)

    Sipka, Sándor

    2016-10-01

    The author describes the concept of "personalized medicine" and the newly introduced "precision medicine". "Precision medicine" applies the terms of "phenotype", "endotype" and "biomarker" in order to characterize more precisely the various diseases. Using "biomarkers" the homogeneous type of a disease (a "phenotype") can be divided into subgroups called "endotypes" requiring different forms of treatment and financing. The good results of "precision medicine" have become especially apparent in relation with allergic and autoimmune diseases. The application of this new way of thinking is going to be necessary in Hungary, too, in the near future for participants, controllers and financing boards of healthcare. Orv. Hetil., 2016, 157(44), 1739-1741.

  8. Precision Clock Evaluation Facility

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Tests and evaluates high-precision atomic clocks for spacecraft, ground, and mobile applications. Supports performance evaluation, environmental testing,...

  9. Precision machining commercialization

    International Nuclear Information System (INIS)

    1978-01-01

    To accelerate precision machining development so as to realize more of the potential savings within the next few years of known Department of Defense (DOD) part procurement, the Air Force Materials Laboratory (AFML) is sponsoring the Precision Machining Commercialization Project (PMC). PMC is part of the Tri-Service Precision Machine Tool Program of the DOD Manufacturing Technology Five-Year Plan. The technical resources supporting PMC are provided under sponsorship of the Department of Energy (DOE). The goal of PMC is to minimize precision machining development time and cost risk for interested vendors. PMC will do this by making available the high precision machining technology as developed in two DOE contractor facilities, the Lawrence Livermore Laboratory of the University of California and the Union Carbide Corporation, Nuclear Division, Y-12 Plant, at Oak Ridge, Tennessee

  10. Precision digital control systems

    Science.gov (United States)

    Vyskub, V. G.; Rozov, B. S.; Savelev, V. I.

    This book is concerned with the characteristics of digital control systems of great accuracy. A classification of such systems is considered along with aspects of stabilization, programmable control applications, digital tracking systems and servomechanisms, and precision systems for the control of a scanning laser beam. Other topics explored are related to systems of proportional control, linear devices and methods for increasing precision, approaches for further decreasing the response time in the case of high-speed operation, possibilities for the implementation of a logical control law, and methods for the study of precision digital control systems. A description is presented of precision automatic control systems which make use of electronic computers, taking into account the existing possibilities for an employment of computers in automatic control systems, approaches and studies required for including a computer in such control systems, and an analysis of the structure of automatic control systems with computers. Attention is also given to functional blocks in the considered systems.

  11. submitter LEP precision results

    CERN Document Server

    Kawamoto, T

    2001-01-01

    Precision measurements at LEP are reviewed, with main focus on the electroweak measurements and tests of the Standard Model. Constraints placed by the LEP measurements on possible new physics are also discussed.

  12. Description of precision colorimeter

    OpenAIRE

    Campos Acosta, Joaquín; Pons Aglio, Alicia; Corróns, Antonio

    1987-01-01

    Describes the use of a fully automatic, computer-controlled absolute spectroradiometer as a precision colorimeter. The chromaticity coordinates of several types of light sources have been obtained with this measurement system.

  13. NCI Precision Medicine

    Science.gov (United States)

    This illustration represents the National Cancer Institute’s support of research to improve precision medicine in cancer treatment, in which unique therapies treat an individual’s cancer based on specific genetic abnormalities of that person’s tumor.

  14. Laser precision microfabrication

    CERN Document Server

    Sugioka, Koji; Pique, Alberto

    2010-01-01

    Miniaturization and high precision are rapidly becoming a requirement for many industrial processes and products. As a result, there is greater interest in the use of laser microfabrication technology to achieve these goals. This book composed of 16 chapters covers all the topics of laser precision processing from fundamental aspects to industrial applications to both inorganic and biological materials. It reviews the sate of the art of research and technological development in the area of laser processing.

  15. The Bayesian Cramér-Rao lower bound in Astrometry

    Science.gov (United States)

    Mendez, R. A.; Echeverria, A.; Silva, J.; Orchard, M.

    2018-01-01

    A determination of the highest precision that can be achieved in the measurement of the location of a stellar-like object has been a topic of permanent interest by the astrometric community. The so-called (parametric, or non-Bayesian) Cramér-Rao (CR hereafter) bound provides a lower bound for the variance with which one could estimate the position of a point source. This has been studied recently by Mendez et al. (2013, 2014, 2015). In this work we present a different approach to the same problem (Echeverria et al. 2016), using a Bayesian CR setting which has a number of advantages over the parametric scenario.

  16. International VLBI Service for Geodesy and Astrometry. Delivering high-quality products and embarking on observations of the next generation

    Science.gov (United States)

    Nothnagel, A.; Artz, T.; Behrend, D.; Malkin, Z.

    2017-07-01

    The International VLBI Service for Geodesy and Astrometry (IVS) regularly produces high-quality Earth orientation parameters from observing sessions employing extensive networks or individual baselines. The master schedule is designed according to the telescope days committed by the stations and by the need for dense sampling of the Earth orientation parameters (EOP). In the pre-2011 era, the network constellations with their number of telescopes participating were limited by the playback and baseline capabilities of the hardware (Mark4) correlators. This limitation was overcome by the advent of software correlators, which can now accommodate many more playback units in a flexible configuration. In this paper, we describe the current operations of the IVS with special emphasis on the quality of the polar motion results since these are the only EOP components which can be validated against independent benchmarks. The polar motion results provided by the IVS have improved continuously over the years, now providing an agreement with IGS results at the level of 20-25 μas in a WRMS sense. At the end of the paper, an outlook is given for the realization of the VLBI Global Observing System.

  17. Precision Experiments at LEP

    CERN Document Server

    de Boer, Wim

    2015-01-01

    The Large Electron Positron Collider (LEP) established the Standard Model (SM) of particle physics with unprecedented precision, including all its radiative corrections. These led to predictions for the masses of the top quark and Higgs boson, which were beautifully confirmed later on. After these precision measurements the Nobel Prize in Physics was awarded in 1999 jointly to 't Hooft and Veltman "for elucidating the quantum structure of electroweak interactions in physics". Another hallmark of the LEP results were the precise measurements of the gauge coupling constants, which excluded unification of the forces within the SM, but allowed unification within the supersymmetric extension of the SM. This increased the interest in Supersymmetry (SUSY) and Grand Unified Theories, especially since the SM has no candidate for the elusive dark matter, while Supersymmetry provides an excellent candidate for dark matter. In addition, Supersymmetry removes the quadratic divergencies of the SM and {\\it predicts} the Hig...

  18. Precision muonium spectroscopy

    International Nuclear Information System (INIS)

    Jungmann, Klaus P.

    2016-01-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 µs. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In particular ground state hyperfine structure transitions can be measured by microwave spectroscopy to deliver the muon magnetic moment. The frequency of the 1s–2s transition in the hydrogen-like atom can be determined with laser spectroscopy to obtain the muon mass. With such measurements fundamental physical interactions, in particular quantum electrodynamics, can also be tested at highest precision. The results are important input parameters for experiments on the muon magnetic anomaly. The simplicity of the atom enables further precise experiments, such as a search for muonium–antimuonium conversion for testing charged lepton number conservation and searches for possible antigravity of muons and dark matter. (author)

  19. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    Precise and stable gene editing in mammalian cell lines has until recently been hampered by the lack of efficient targeting methods. While different gene silencing strategies have had tremendous impact on many biological fields, they have generally not been applied with wide success in the field...... of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...

  20. Precision electron polarimetry

    International Nuclear Information System (INIS)

    Chudakov, E.

    2013-01-01

    A new generation of precise Parity-Violating experiments will require a sub-percent accuracy of electron beam polarimetry. Compton polarimetry can provide such accuracy at high energies, but at a few hundred MeV the small analyzing power limits the sensitivity. Mo/ller polarimetry provides a high analyzing power independent on the beam energy, but is limited by the properties of the polarized targets commonly used. Options for precision polarimetry at 300 MeV will be discussed, in particular a proposal to use ultra-cold atomic hydrogen traps to provide a 100%-polarized electron target for Mo/ller polarimetry

  1. A passion for precision

    CERN Multimedia

    CERN. Geneva. Audiovisual Unit

    2006-01-01

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.

  2. Improving Precision of Types

    DEFF Research Database (Denmark)

    Winther, Johnni

    Types in programming languages provide a powerful tool for the programmer to document the code so that a large aspect of the intent can not only be presented to fellow programmers but also be checked automatically by compilers. The precision with which types model the behavior of programs...... is crucial to the quality of these automated checks, and in this thesis we present three different improvements to the precision of types in three different aspects of the Java programming language. First we show how to extend the type system in Java with a new type which enables the detection of unintended...

  3. IMPROVING GALACTIC CENTER ASTROMETRY BY REDUCING THE EFFECTS OF GEOMETRIC DISTORTION

    International Nuclear Information System (INIS)

    Yelda, S.; Ghez, A. M.; Clarkson, W.; Lu, J. R.; Matthews, K.; Anderson, J.; Do, T.

    2010-01-01

    We present significantly improved proper motion measurements of the Milky Way's central stellar cluster. These improvements are made possible by refining our astrometric reference frame with a new geometric optical distortion model for the W. M. Keck II 10 m telescope's adaptive optics camera (NIRC2) in its narrow field mode. For the first time, this distortion model is constructed from on-sky measurements and is made available to the public in the form of FITS files. When applied to widely dithered images, it produces residuals in the separations of stars that are a factor of ∼3 smaller compared with the outcome using previous models. By applying this new model, along with corrections for differential atmospheric refraction, to widely dithered images of SiO masers at the Galactic center (GC), we improve our ability to tie into the precisely measured radio Sgr A*-rest frame. The resulting infrared reference frame is ∼2-3 times more accurate and stable than earlier published efforts. In this reference frame, Sgr A* is localized to within a position of 0.6 mas and a velocity of 0.09 mas yr -1 , or ∼3.4 km s -1 at 8 kpc (1σ). Also, proper motions for members of the central stellar cluster are more accurate, although less precise, due to the limited number of these wide field measurements. These proper motion measurements show that, with respect to Sgr A*, the central stellar cluster has no rotation in the plane of the sky to within 0.3 mas yr -1 arcsec -1 , has no net translational motion with respect to Sgr A* to within 0.1 mas yr -1 , and has net rotation perpendicular to the plane of the sky along the Galactic plane, as has previously been observed. While earlier proper motion studies defined a reference frame by assuming no net motion of the stellar cluster, this approach is fundamentally limited by the cluster's intrinsic dispersion and therefore will not improve with time. We define a reference frame with SiO masers and this reference frame's stability

  4. Precision physics at LHC

    International Nuclear Information System (INIS)

    Hinchliffe, I.

    1997-05-01

    In this talk the author gives a brief survey of some physics topics that will be addressed by the Large Hadron Collider currently under construction at CERN. Instead of discussing the reach of this machine for new physics, the author gives examples of the types of precision measurements that might be made if new physics is discovered

  5. Precision Muonium Spectroscopy

    NARCIS (Netherlands)

    Jungmann, Klaus P.

    2016-01-01

    The muonium atom is the purely leptonic bound state of a positive muon and an electron. It has a lifetime of 2.2 mu s. The absence of any known internal structure provides for precision experiments to test fundamental physics theories and to determine accurate values of fundamental constants. In

  6. What is precision medicine?

    Science.gov (United States)

    König, Inke R; Fuchs, Oliver; Hansen, Gesine; von Mutius, Erika; Kopp, Matthias V

    2017-10-01

    The term "precision medicine" has become very popular over recent years, fuelled by scientific as well as political perspectives. Despite its popularity, its exact meaning, and how it is different from other popular terms such as "stratified medicine", "targeted therapy" or "deep phenotyping" remains unclear. Commonly applied definitions focus on the stratification of patients, sometimes referred to as a novel taxonomy, and this is derived using large-scale data including clinical, lifestyle, genetic and further biomarker information, thus going beyond the classical "signs-and-symptoms" approach.While these aspects are relevant, this description leaves open a number of questions. For example, when does precision medicine begin? In which way does the stratification of patients translate into better healthcare? And can precision medicine be viewed as the end-point of a novel stratification of patients, as implied, or is it rather a greater whole?To clarify this, the aim of this paper is to provide a more comprehensive definition that focuses on precision medicine as a process. It will be shown that this proposed framework incorporates the derivation of novel taxonomies and their role in healthcare as part of the cycle, but also covers related terms. Copyright ©ERS 2017.

  7. The Tropospheric Products of the International VLBI Service for Geodesy and Astrometry

    Science.gov (United States)

    Heinkelmann, Robert; Schwatke, Christian

    2010-01-01

    The IVS runs two tropospheric products: The IVS tropospheric parameter rapid combination monitors the zenith wet delay (ZWD) and zenith total delay (ZTD) of the rapid turnaround sessions R1 and R4. Goal of the combination is the identification and the exclusion of outliers by comparison and the assessment of the precision of current VLBI solutions in terms of tropospheric parameters. The rapid combination is done on a weekly basis four weeks after the observation files are released on IVS Data Centers. Since tropospheric and geodetic parameters, such as vertical station components, can significantly correlate, the consistency of the ZTD can be a measure of the consistency of the corresponding TRF as well. The ZWD mainly rely on accurate atmospheric pressure data. Thus, besides estimation techniques, modeling and analyst s noise, ZWD reflects differences in the atmospheric pressure data applied to the VLBI analysis. The second product, called tropospheric parameter long-term combination, aims for an accurate determination of climatological signals, such as trends of the atmospheric water vapor observed by VLBI. Therefore, the long-term homogeneity of atmospheric pressure data plays a crucial role for this product. The paper reviews the methods applied and results achieved so far and describes the new maintenance through DGFI.

  8. Comparison of pulsar positions from timing and very long baseline astrometry

    Science.gov (United States)

    Wang, J. B.; Coles, W. A.; Hobbs, G.; Shannon, R. M.; Manchester, R. N.; Kerr, M.; Yuan, J. P.; Wang, N.; Bailes, M.; Bhat, N. D. R.; Dai, S.; Dempsey, J.; Keith, M. J.; Lasky, P. D.; Levin, Y.; Osłowski, S.; Ravi, V.; Reardon, D. J.; Rosado, P. A.; Russell, C. J.; Spiewak, R.; van Straten, W.; Toomey, L.; Wen, L.; You, X.-P.; Zhu, X.-J.

    2017-07-01

    Pulsar positions can be measured with high precision using both pulsar timing methods and very long baseline interferometry (VLBI). Pulsar timing positions are referenced to a solar-system ephemeris, whereas VLBI positions are referenced to distant quasars. Here, we compare pulsar positions from published VLBI measurements with those obtained from pulsar timing data from the Nanshan and Parkes radio telescopes in order to relate the two reference frames. We find that the timing positions differ significantly from the VLBI positions (and also differ between different ephemerides). A statistically significant change in the obliquity of the ecliptic of 2.16 ± 0.33 mas is found for the JPL ephemeris DE405, but no significant rotation is found in subsequent JPL ephemerides. The accuracy with which we can relate the two frames is limited by the current uncertainties in the VLBI reference source positions and in matching the pulsars to their reference source. Not only do the timing positions depend on the ephemeris used in computing them, but also different segments of the timing data lead to varying position estimates. These variations are mostly common to all ephemerides, but slight changes are seen at the 10 μas level between ephemerides.

  9. Precision synchrotron radiation detectors

    International Nuclear Information System (INIS)

    Levi, M.; Rouse, F.; Butler, J.

    1989-03-01

    Precision detectors to measure synchrotron radiation beam positions have been designed and installed as part of beam energy spectrometers at the Stanford Linear Collider (SLC). The distance between pairs of synchrotron radiation beams is measured absolutely to better than 28 /mu/m on a pulse-to-pulse basis. This contributes less than 5 MeV to the error in the measurement of SLC beam energies (approximately 50 GeV). A system of high-resolution video cameras viewing precisely-aligned fiducial wire arrays overlaying phosphorescent screens has achieved this accuracy. Also, detectors of synchrotron radiation using the charge developed by the ejection of Compton-recoil electrons from an array of fine wires are being developed. 4 refs., 5 figs., 1 tab

  10. A passion for precision

    CERN Multimedia

    CERN. Geneva

    2006-01-01

    For more than three decades, the quest for ever higher precision in laser spectroscopy of the simple hydrogen atom has inspired many advances in laser, optical, and spectroscopic techniques, culminating in femtosecond laser optical frequency combs  as perhaps the most precise measuring tools known to man. Applications range from optical atomic clocks and tests of QED and relativity to searches for time variations of fundamental constants. Recent experiments are extending frequency comb techniques into the extreme ultraviolet. Laser frequency combs can also control the electric field of ultrashort light pulses, creating powerful new tools for the emerging field of attosecond science.Organiser(s): L. Alvarez-Gaume / PH-THNote: * Tea & coffee will be served at 16:00.

  11. Quad precision delay generator

    International Nuclear Information System (INIS)

    Krishnan, Shanti; Gopalakrishnan, K.R.; Marballi, K.R.

    1997-01-01

    A Quad Precision Delay Generator delays a digital edge by a programmed amount of time, varying from nanoseconds to microseconds. The output of this generator has an amplitude of the order of tens of volts and rise time of the order of nanoseconds. This was specifically designed and developed to meet the stringent requirements of the plasma focus experiments. Plasma focus is a laboratory device for producing and studying nuclear fusion reactions in hot deuterium plasma. 3 figs

  12. A PRECISION MULTI-BAND TWO-EPOCH PHOTOMETRIC CATALOG OF 44 MILLION SOURCES IN THE NORTHERN SKY FROM A COMBINATION OF THE USNO-B AND SLOAN DIGITAL SKY SURVEY CATALOGS

    International Nuclear Information System (INIS)

    Madsen, G. J.; Gaensler, B. M.

    2013-01-01

    A key science driver for the next generation of wide-field optical and radio surveys is the exploration of the time variable sky. These surveys will have unprecedented sensitivity and areal coverage, but will be limited in their ability to detect variability on time scales longer than the lifetime of the surveys. We present a new precision, multi-epoch photometric catalog that spans 60 yr by combining the US Naval Observatory-B (USNO-B) and Sloan Digital Sky Survey (SDSS) Data Release 9 (DR9) catalogs. We recalibrate the photometry of the original USNO-B catalog and create a catalog with two epochs of photometry in up to five different bands for 43,647,887 optical point sources that lie in the DR9 footprint of the northern sky. The recalibrated objects span a magnitude range 14 ≲ m ≲ 20 and are accurate to ≈0.1 mag. We minimize the presence of spurious objects and those with inaccurate magnitudes by identifying and removing several sources of systematic errors in the two originating catalogs, with a focus on spurious objects that exhibit large apparent magnitude variations. After accounting for these effects, we find ≈250,000 stars and quasars that show significant (≥4σ) changes in brightness between the USNO-B and SDSS DR9 epochs. We discuss the historical value of the catalog and its application to the study of long time scale, large amplitude variable stars and quasars

  13. Astrometry and early astrophysics at Kuffner Observatory in the late 19th century

    Science.gov (United States)

    Habison, Peter

    The astronomer and mathematician Norbert Herz encouraged Moriz von Kuffner, owner of the beer brewery in Ottakring, to finance a private scientific observatory in the western parts of Vienna. In the years 1884-87 the Kuffner Observatory was built at the Gallitzinberg in Wien-Ottakring. It was an example of enlighted patronage and noted at the time for its rapid acquisition of new instruments and by increasing international recognition. It contained the largest heliometer in the world and the largest meridian circle in the Austrian-Hungarian Empire. Of the many scientists who worked here we mention Leo de Ball, Gustav Eberhard, Johannes Hartmann and we should not forget Karl Schwarzschild. Here in Vienna he published papers on celestial mechanics, measuring techniques, optics and his fundamental papers concerning photographic photometry, in particular the quantitative determination of the departure of the reciprocity law. The telescope and the associated camera with which he carried out his measurements are still in existence at the observatory. The observatory houses important astronomical instruments from the 19th century. All telescopes were made by Repsold und Söhne in Hamburg, and Steinheil in Munich. These two German companies were best renowned for quality and precision in high standard astronomical instruments. The Great Refractor (270/3500 mm) is still the third largest refractor in Austria. It was installed at the observatory in 1886 and was used together with the Schwarzschild Refractor for early astrophysical work including photography. It is this double refractor, where Schwarzschild carried out his measurements on photographic photometry. The Meridian Circle (132/1500 mm) was the largest meridian passage instrument of the Austro-Hungarian Empire. Today it is the largest meridian circle in Austria and still one of the largest in Europe. The telescope is equipped with one of the first impersonal micrometers of that time. First observations were carried

  14. Precision electroweak measurements

    International Nuclear Information System (INIS)

    Demarteau, M.

    1996-11-01

    Recent electroweak precision measurements fro e + e - and p anti p colliders are presented. Some emphasis is placed on the recent developments in the heavy flavor sector. The measurements are compared to predictions from the Standard Model of electroweak interactions. All results are found to be consistent with the Standard Model. The indirect constraint on the top quark mass from all measurements is in excellent agreement with the direct m t measurements. Using the world's electroweak data in conjunction with the current measurement of the top quark mass, the constraints on the Higgs' mass are discussed

  15. Electroweak precision tests

    International Nuclear Information System (INIS)

    Monteil, St.

    2009-12-01

    This document aims at summarizing a dozen of years of the author's research in High Energy Physics, in particular dealing with precision tests of the electroweak theory. Parity violating asymmetries measurements at LEP with the ALEPH detector together with global consistency checks of the Kobayashi-Maskawa paradigm within the CKM-fitter group are gathered in the first part of the document. The second part deals with the unpublished instrumental work about the design, tests, productions and commissioning of the elements of the Pre-Shower detector of the LHCb spectrometer at LHC. Physics perspectives with LHCb are eventually discussed as a conclusion. (author)

  16. Ultra-precision bearings

    CERN Document Server

    Wardle, F

    2015-01-01

    Ultra-precision bearings can achieve extreme accuracy of rotation, making them ideal for use in numerous applications across a variety of fields, including hard disk drives, roundness measuring machines and optical scanners. Ultraprecision Bearings provides a detailed review of the different types of bearing and their properties, as well as an analysis of the factors that influence motion error, stiffness and damping. Following an introduction to basic principles of motion error, each chapter of the book is then devoted to the basic principles and properties of a specific type of bearin

  17. Precision lifetime measurements

    International Nuclear Information System (INIS)

    Tanner, C.E.

    1994-01-01

    Precision measurements of atomic lifetimes provide important information necessary for testing atomic theory. The authors employ resonant laser excitation of a fast atomic beam to measure excited state lifetimes by observing the decay-in-flight of the emitted fluorescence. A similar technique was used by Gaupp, et al., who reported measurements with precisions of less than 0.2%. Their program includes lifetime measurements of the low lying p states in alkali and alkali like systems. Motivation for this work comes from a need to test the atomic many-body-perturbation theory (MBPT) that is necessary for interpretation of parity nonconservation experiments in atomic cesium. The authors have measured the cesium 6p 2 P 1/2 and 6p 2 P 3/2 state lifetimes to be 34.934±0.094 ns and 30.499±0.070 ns respectively. With minor changes to the apparatus, they have extended their measurements to include the lithium 2p 2 P 1/2 and 2p 2 P 3/2 states

  18. Fundamentals of precision medicine

    Science.gov (United States)

    Divaris, Kimon

    2018-01-01

    Imagine a world where clinicians make accurate diagnoses and provide targeted therapies to their patients according to well-defined, biologically-informed disease subtypes, accounting for individual differences in genetic make-up, behaviors, cultures, lifestyles and the environment. This is not as utopic as it may seem. Relatively recent advances in science and technology have led to an explosion of new information on what underlies health and what constitutes disease. These novel insights emanate from studies of the human genome and microbiome, their associated transcriptomes, proteomes and metabolomes, as well as epigenomics and exposomics—such ‘omics data can now be generated at unprecedented depth and scale, and at rapidly decreasing cost. Making sense and integrating these fundamental information domains to transform health care and improve health remains a challenge—an ambitious, laudable and high-yield goal. Precision dentistry is no longer a distant vision; it is becoming part of the rapidly evolving present. Insights from studies of the human genome and microbiome, their associated transcriptomes, proteomes and metabolomes, and epigenomics and exposomics have reached an unprecedented depth and scale. Much more needs to be done, however, for the realization of precision medicine in the oral health domain. PMID:29227115

  19. Precision measurements in supersymmetry

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Johnathan Lee [Stanford Univ., CA (United States)

    1995-05-01

    Supersymmetry is a promising framework in which to explore extensions of the standard model. If candidates for supersymmetric particles are found, precision measurements of their properties will then be of paramount importance. The prospects for such measurements and their implications are the subject of this thesis. If charginos are produced at the LEP II collider, they are likely to be one of the few available supersymmetric signals for many years. The author considers the possibility of determining fundamental supersymmetry parameters in such a scenario. The study is complicated by the dependence of observables on a large number of these parameters. He proposes a straightforward procedure for disentangling these dependences and demonstrate its effectiveness by presenting a number of case studies at representative points in parameter space. In addition to determining the properties of supersymmetric particles, precision measurements may also be used to establish that newly-discovered particles are, in fact, supersymmetric. Supersymmetry predicts quantitative relations among the couplings and masses of superparticles. The author discusses tests of such relations at a future e{sup +}e{sup {minus}} linear collider, using measurements that exploit the availability of polarizable beams. Stringent tests of supersymmetry from chargino production are demonstrated in two representative cases, and fermion and neutralino processes are also discussed.

  20. Precision muon physics

    Science.gov (United States)

    Gorringe, T. P.; Hertzog, D. W.

    2015-09-01

    The muon is playing a unique role in sub-atomic physics. Studies of muon decay both determine the overall strength and establish the chiral structure of weak interactions, as well as setting extraordinary limits on charged-lepton-flavor-violating processes. Measurements of the muon's anomalous magnetic moment offer singular sensitivity to the completeness of the standard model and the predictions of many speculative theories. Spectroscopy of muonium and muonic atoms gives unmatched determinations of fundamental quantities including the magnetic moment ratio μμ /μp, lepton mass ratio mμ /me, and proton charge radius rp. Also, muon capture experiments are exploring elusive features of weak interactions involving nucleons and nuclei. We will review the experimental landscape of contemporary high-precision and high-sensitivity experiments with muons. One focus is the novel methods and ingenious techniques that achieve such precision and sensitivity in recent, present, and planned experiments. Another focus is the uncommonly broad and topical range of questions in atomic, nuclear and particle physics that such experiments explore.

  1. Precision Joining Center

    Science.gov (United States)

    Powell, J. W.; Westphal, D. A.

    1991-08-01

    A workshop to obtain input from industry on the establishment of the Precision Joining Center (PJC) was held on July 10-12, 1991. The PJC is a center for training Joining Technologists in advanced joining techniques and concepts in order to promote the competitiveness of U.S. industry. The center will be established as part of the DOE Defense Programs Technology Commercialization Initiative, and operated by EG&G Rocky Flats in cooperation with the American Welding Society and the Colorado School of Mines Center for Welding and Joining Research. The overall objectives of the workshop were to validate the need for a Joining Technologists to fill the gap between the welding operator and the welding engineer, and to assure that the PJC will train individuals to satisfy that need. The consensus of the workshop participants was that the Joining Technologist is a necessary position in industry, and is currently used, with some variation, by many companies. It was agreed that the PJC core curriculum, as presented, would produce a Joining Technologist of value to industries that use precision joining techniques. The advantage of the PJC would be to train the Joining Technologist much more quickly and more completely. The proposed emphasis of the PJC curriculum on equipment intensive and hands-on training was judged to be essential.

  2. VizieR Online Data Catalog: 2007.5 to 2010.4 HST astrometry of HD 202206 (Benedict+, 2017)

    Science.gov (United States)

    Benedict, G. F.; Harrison, T. E.

    2017-08-01

    For this study astrometric measurements came from Fine Guidance Sensor 1r (FGS 1r), an upgraded FGS installed in 1997 during the second Hubble Space Telescope (HST) servicing mission. It provided superior fringes from which to obtain target and reference star positions (McArthur et al. 2003hstc.conf..373M). We utilized only the fringe tracking mode (POS mode) in this investigation. POS mode observations of a star have a typical duration of 60s, during which over 2000 individual position measures are collected. The astrometric centroid is estimated by choosing the median measure, after filtering large outliers (caused by cosmic-ray hits and particles trapped by the Earth's magnetic field). The standard deviation of the measures provides a measurement error. We refer to the aggregate of astrometric centroids of each star secured during one visibility period as an "orbit". Because one of the pillars of the scientific method involves reproducibility, we present a complete ensemble of time-tagged HD202206 and reference star astrometric measurements, Optical Field Angle Distortion (OFAD; McArthur et al. 2006hstc.conf..396M) and intra-orbit-drift-corrected, in Table2, along with calculated parallax factors in R.A. and decl. These data, collected from 2007.5 to 2010.4, in addition to providing material for confirmation of our results, might ultimately be combined with Gaia measures, significantly extending the time baseline of astrometry, thereby improving proper motion and perturbation characterization. Our band passes for reference star photometry include: BVRI photometry of the reference stars from the NMSU 1m telescope located at Apache Point Observatory and JHK (from 2MASS; see Cutri et al. 2003, Cat. II/246). Table4 lists the visible and infrared photometry for the HD202206 reference stars. To establish spectral type and luminosity class, the reference frame stars were observed on 2009 December 9 using the RCSPEC on the Blanco 4m telescope at Cerro Tololo Inter

  3. Precision Medicine in Cancer Treatment

    Science.gov (United States)

    Precision medicine helps doctors select cancer treatments that are most likely to help patients based on a genetic understanding of their disease. Learn about the promise of precision medicine and the role it plays in cancer treatment.

  4. Precision Medicine in Cardiovascular Diseases

    Directory of Open Access Journals (Sweden)

    Yan Liu

    2017-02-01

    Full Text Available Since President Obama announced the Precision Medicine Initiative in the United States, more and more attention has been paid to precision medicine. However, clinicians have already used it to treat conditions such as cancer. Many cardiovascular diseases have a familial presentation, and genetic variants are associated with the prevention, diagnosis, and treatment of cardiovascular diseases, which are the basis for providing precise care to patients with cardiovascular diseases. Large-scale cohorts and multiomics are critical components of precision medicine. Here we summarize the application of precision medicine to cardiovascular diseases based on cohort and omic studies, and hope to elicit discussion about future health care.

  5. Precisely predictable Dirac observables

    CERN Document Server

    Cordes, Heinz Otto

    2006-01-01

    This work presents a "Clean Quantum Theory of the Electron", based on Dirac’s equation. "Clean" in the sense of a complete mathematical explanation of the well known paradoxes of Dirac’s theory, and a connection to classical theory, including the motion of a magnetic moment (spin) in the given field, all for a charged particle (of spin ½) moving in a given electromagnetic field. This theory is relativistically covariant, and it may be regarded as a mathematically consistent quantum-mechanical generalization of the classical motion of such a particle, à la Newton and Einstein. Normally, our fields are time-independent, but also discussed is the time-dependent case, where slightly different features prevail. A "Schroedinger particle", such as a light quantum, experiences a very different (time-dependent) "Precise Predictablity of Observables". An attempt is made to compare both cases. There is not the Heisenberg uncertainty of location and momentum; rather, location alone possesses a built-in uncertainty ...

  6. Prompt and Precise Prototyping

    Science.gov (United States)

    2003-01-01

    For Sanders Design International, Inc., of Wilton, New Hampshire, every passing second between the concept and realization of a product is essential to succeed in the rapid prototyping industry where amongst heavy competition, faster time-to-market means more business. To separate itself from its rivals, Sanders Design aligned with NASA's Marshall Space Flight Center to develop what it considers to be the most accurate rapid prototyping machine for fabrication of extremely precise tooling prototypes. The company's Rapid ToolMaker System has revolutionized production of high quality, small-to-medium sized prototype patterns and tooling molds with an exactness that surpasses that of computer numerically-controlled (CNC) machining devices. Created with funding and support from Marshall under a Small Business Innovation Research (SBIR) contract, the Rapid ToolMaker is a dual-use technology with applications in both commercial and military aerospace fields. The advanced technology provides cost savings in the design and manufacturing of automotive, electronic, and medical parts, as well as in other areas of consumer interest, such as jewelry and toys. For aerospace applications, the Rapid ToolMaker enables fabrication of high-quality turbine and compressor blades for jet engines on unmanned air vehicles, aircraft, and missiles.

  7. Precisely Tracking Childhood Death.

    Science.gov (United States)

    Farag, Tamer H; Koplan, Jeffrey P; Breiman, Robert F; Madhi, Shabir A; Heaton, Penny M; Mundel, Trevor; Ordi, Jaume; Bassat, Quique; Menendez, Clara; Dowell, Scott F

    2017-07-01

    Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death. The Bill & Melinda Gates Foundation is supporting a new surveillance system called the Child Health and Mortality Prevention Surveillance network, which will determine cause of death using MITS in combination with other information, and yield cause-specific population-based mortality rates, eventually in up to 12-15 sites in sub-Saharan Africa and south Asia. However, the Gates Foundation funding alone is not enough. We call on governments, other funders, and international stakeholders to expand the use of pathology-based cause of death determination to provide the information needed to end preventable childhood mortality.

  8. Precise Truss Assembly Using Commodity Parts and Low Precision Welding

    Science.gov (United States)

    Komendera, Erik; Reishus, Dustin; Dorsey, John T.; Doggett, W. R.; Correll, Nikolaus

    2014-01-01

    Hardware and software design and system integration for an intelligent precision jigging robot (IPJR), which allows high precision assembly using commodity parts and low-precision bonding, is described. Preliminary 2D experiments that are motivated by the problem of assembling space telescope optical benches and very large manipulators on orbit using inexpensive, stock hardware and low-precision welding are also described. An IPJR is a robot that acts as the precise "jigging", holding parts of a local structure assembly site in place, while an external low precision assembly agent cuts and welds members. The prototype presented in this paper allows an assembly agent (for this prototype, a human using only low precision tools), to assemble a 2D truss made of wooden dowels to a precision on the order of millimeters over a span on the order of meters. The analysis of the assembly error and the results of building a square structure and a ring structure are discussed. Options for future work, to extend the IPJR paradigm to building in 3D structures at micron precision are also summarized.

  9. [Precision nutrition in the era of precision medicine].

    Science.gov (United States)

    Chen, P Z; Wang, H

    2016-12-06

    Precision medicine has been increasingly incorporated into clinical practice and is enabling a new era for disease prevention and treatment. As an important constituent of precision medicine, precision nutrition has also been drawing more attention during physical examinations. The main aim of precision nutrition is to provide safe and efficient intervention methods for disease treatment and management, through fully considering the genetics, lifestyle (dietary, exercise and lifestyle choices), metabolic status, gut microbiota and physiological status (nutrient level and disease status) of individuals. Three major components should be considered in precision nutrition, including individual criteria for sufficient nutritional status, biomarker monitoring or techniques for nutrient detection and the applicable therapeutic or intervention methods. It was suggested that, in clinical practice, many inherited and chronic metabolic diseases might be prevented or managed through precision nutritional intervention. For generally healthy populations, because lifestyles, dietary factors, genetic factors and environmental exposures vary among individuals, precision nutrition is warranted to improve their physical activity and reduce disease risks. In summary, research and practice is leading toward precision nutrition becoming an integral constituent of clinical nutrition and disease prevention in the era of precision medicine.

  10. Precision medicine in myasthenia graves: begin from the data precision

    Science.gov (United States)

    Hong, Yu; Xie, Yanchen; Hao, Hong-Jun; Sun, Ren-Cheng

    2016-01-01

    Myasthenia gravis (MG) is a prototypic autoimmune disease with overt clinical and immunological heterogeneity. The data of MG is far from individually precise now, partially due to the rarity and heterogeneity of this disease. In this review, we provide the basic insights of MG data precision, including onset age, presenting symptoms, generalization, thymus status, pathogenic autoantibodies, muscle involvement, severity and response to treatment based on references and our previous studies. Subgroups and quantitative traits of MG are discussed in the sense of data precision. The role of disease registries and scientific bases of precise analysis are also discussed to ensure better collection and analysis of MG data. PMID:27127759

  11. MEASUREMENT AND PRECISION, EXPERIMENTAL VERSION.

    Science.gov (United States)

    Harvard Univ., Cambridge, MA. Harvard Project Physics.

    THIS DOCUMENT IS AN EXPERIMENTAL VERSION OF A PROGRAMED TEXT ON MEASUREMENT AND PRECISION. PART I CONTAINS 24 FRAMES DEALING WITH PRECISION AND SIGNIFICANT FIGURES ENCOUNTERED IN VARIOUS MATHEMATICAL COMPUTATIONS AND MEASUREMENTS. PART II BEGINS WITH A BRIEF SECTION ON EXPERIMENTAL DATA, COVERING SUCH POINTS AS (1) ESTABLISHING THE ZERO POINT, (2)…

  12. Multi-Epoch Hubble Space Telescope Observations of IZw18 : Characterization of Variable Stars at Ultra-Low Metallicities

    NARCIS (Netherlands)

    Fiorentino, G.; Ramos, R. Contreras; Clementini, G.; Marconi, M.; Musella, I.; Aloisi, A.; Annibali, F.; Saha, A.; Tosi, M.; van der Marel, R. P.

    2010-01-01

    Variable stars have been identified for the first time in the very metal-poor blue compact dwarf galaxy IZw18, using deep multi-band (F606W, F814W) time-series photometry obtained with the Advanced Camera for Surveys on board the Hubble Space Telescope. We detected 34 candidate variable stars in the

  13. Chemical Compositions of Stars in the Globular Cluster NGC 3201: Tracers of Multi-Epoch Star Formation

    Science.gov (United States)

    Simmerer, Jennifer A.; Ivans, I. I.; Filler, D.

    2012-01-01

    The retrograde halo globular cluster NGC 3201 contains stars of substantially different iron abundance ([Fe/H]), a property that puts it at odds with the vast majority of the Galactic cluster system. Though its unusual orbit prompted speculation that NGC 3201 was the remnant of a captured object, much like the multi-metallicity globular cluster Omega Centauri, NGC 3201 is much less massive than Omega Centauri and all of the other halo globular clusters that have internal metallicity variations. We present the abundances of 21 elements in 24 red giant branch stars in NGC 3201 based on high-resolution (R 40,000), high signal-to-noise (S/N 70) spectra. We find that the detailed abundance pattern of NGC 3201 is unique amongst multi-metallicity halo clusters. Unlike M22, Omega Centauri, and NGC 1851, neither metal-poor nor metal-rich stars show any evidence of s-process enrichment (a product of the advanced evolution of low- and intermediate-mass stars). We find that while Na, O, and Al vary from star to star as is typical in globular clusters, there is no systematic difference between the abundance pattern in the metal-poor cluster stars and that of the metal-rich cluster stars. Furthermore, we find that the metallicity variations in NGC 3201 are independent of the well-known Na-O anticorrelation, which separates it from every other multi-metallicity cluster. In the context of a multi-episode star formation model, this implies that NGC 3201 began life with the [Fe/H] variations we measure now.

  14. Precision medicine for nurses: 101.

    Science.gov (United States)

    Lemoine, Colleen

    2014-05-01

    To introduce the key concepts and terms associated with precision medicine and support understanding of future developments in the field by providing an overview and history of precision medicine, related ethical considerations, and nursing implications. Current nursing, medical and basic science literature. Rapid progress in understanding the oncogenic drivers associated with cancer is leading to a shift toward precision medicine, where treatment is based on targeting specific genetic and epigenetic alterations associated with a particular cancer. Nurses will need to embrace the paradigm shift to precision medicine, expend the effort necessary to learn the essential terminology, concepts and principles, and work collaboratively with physician colleagues to best position our patients to maximize the potential that precision medicine can offer. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. High precision predictions for near-Earth asteroids: the strange case of (3908) Nyx

    Science.gov (United States)

    Farnocchia, D.; Chesley, S. R.; Tholen, D. J.; Micheli, M.

    2014-08-01

    In November 2004 radar delay measurements of near-Earth asteroid (3908) Nyx obtained at the Arecibo radio telescope turned out to be away from the orbital prediction. We prove that this discrepancy was caused by a poor astrometric treatment and an incomplete dynamical model, which did not account for nongravitational perturbations. To improve the astrometric treatment, we remove known star catalog biases, apply suitable weights to the observations, and use an aggressive outlier rejection scheme. The main issue related to the dynamical model is having not accounted for the Yarkovsky effect. Including the Yarkovsky perturbation in the model makes the orbital prediction and the radar measurements statistically consistent by both reducing the offset and increasing the prediction uncertainty to a more realistic level. This analysis shows the sensitivity of high precision predictions to the astrometric treatment and the Yarkovsky effect. By using the full observational dataset we obtain a detection of the Yarkovsky effect acting on Nyx corresponding to an orbital drift m/year. In turn, we derive constraints on thermal inertia and bulk density. In particular, we find that the bulk density of Nyx is around 1 g/cm, possibly less. To make sure that our results are not corrupted by an asteroid impact or a close approach with a perturbing asteroid not included in our dynamical model, we show that the astrometry provides no convincing evidence of an impulsive variation of Nyx's velocity while crossing the main belt region.

  16. Advanced bioanalytics for precision medicine.

    Science.gov (United States)

    Roda, Aldo; Michelini, Elisa; Caliceti, Cristiana; Guardigli, Massimo; Mirasoli, Mara; Simoni, Patrizia

    2018-01-01

    Precision medicine is a new paradigm that combines diagnostic, imaging, and analytical tools to produce accurate diagnoses and therapeutic interventions tailored to the individual patient. This approach stands in contrast to the traditional "one size fits all" concept, according to which researchers develop disease treatments and preventions for an "average" patient without considering individual differences. The "one size fits all" concept has led to many ineffective or inappropriate treatments, especially for pathologies such as Alzheimer's disease and cancer. Now, precision medicine is receiving massive funding in many countries, thanks to its social and economic potential in terms of improved disease prevention, diagnosis, and therapy. Bioanalytical chemistry is critical to precision medicine. This is because identifying an appropriate tailored therapy requires researchers to collect and analyze information on each patient's specific molecular biomarkers (e.g., proteins, nucleic acids, and metabolites). In other words, precision diagnostics is not possible without precise bioanalytical chemistry. This Trend article highlights some of the most recent advances, including massive analysis of multilayer omics, and new imaging technique applications suitable for implementing precision medicine. Graphical abstract Precision medicine combines bioanalytical chemistry, molecular diagnostics, and imaging tools for performing accurate diagnoses and selecting optimal therapies for each patient.

  17. Precision Oncology: Between Vaguely Right and Precisely Wrong.

    Science.gov (United States)

    Brock, Amy; Huang, Sui

    2017-12-01

    Precision Oncology seeks to identify and target the mutation that drives a tumor. Despite its straightforward rationale, concerns about its effectiveness are mounting. What is the biological explanation for the "imprecision?" First, Precision Oncology relies on indiscriminate sequencing of genomes in biopsies that barely represent the heterogeneous mix of tumor cells. Second, findings that defy the orthodoxy of oncogenic "driver mutations" are now accumulating: the ubiquitous presence of oncogenic mutations in silent premalignancies or the dynamic switching without mutations between various cell phenotypes that promote progression. Most troublesome is the observation that cancer cells that survive treatment still will have suffered cytotoxic stress and thereby enter a stem cell-like state, the seeds for recurrence. The benefit of "precision targeting" of mutations is inherently limited by this counterproductive effect. These findings confirm that there is no precise linear causal relationship between tumor genotype and phenotype, a reminder of logician Carveth Read's caution that being vaguely right may be preferable to being precisely wrong. An open-minded embrace of the latest inconvenient findings indicating nongenetic and "imprecise" phenotype dynamics of tumors as summarized in this review will be paramount if Precision Oncology is ultimately to lead to clinical benefits. Cancer Res; 77(23); 6473-9. ©2017 AACR . ©2017 American Association for Cancer Research.

  18. Numerical precision control and GRACE

    International Nuclear Information System (INIS)

    Fujimoto, J.; Hamaguchi, N.; Ishikawa, T.; Kaneko, T.; Morita, H.; Perret-Gallix, D.; Tokura, A.; Shimizu, Y.

    2006-01-01

    The control of the numerical precision of large-scale computations like those generated by the GRACE system for automatic Feynman diagram calculations has become an intrinsic part of those packages. Recently, Hitachi Ltd. has developed in FORTRAN a new library HMLIB for quadruple and octuple precision arithmetic where the number of lost-bits is made available. This library has been tested with success on the 1-loop radiative correction to e + e - ->e + e - τ + τ - . It is shown that the approach followed by HMLIB provides an efficient way to track down the source of numerical significance losses and to deliver high-precision results yet minimizing computing time

  19. Lung Cancer Precision Medicine Trials

    Science.gov (United States)

    Patients with lung cancer are benefiting from the boom in targeted and immune-based therapies. With a series of precision medicine trials, NCI is keeping pace with the rapidly changing treatment landscape for lung cancer.

  20. Precision engineering: an evolutionary perspective.

    Science.gov (United States)

    Evans, Chris J

    2012-08-28

    Precision engineering is a relatively new name for a technology with roots going back over a thousand years; those roots span astronomy, metrology, fundamental standards, manufacturing and money-making (literally). Throughout that history, precision engineers have created links across disparate disciplines to generate innovative responses to society's needs and wants. This review combines historical and technological perspectives to illuminate precision engineering's current character and directions. It first provides us a working definition of precision engineering and then reviews the subject's roots. Examples will be given showing the contributions of the technology to society, while simultaneously showing the creative tension between the technological convergence that spurs new directions and the vertical disintegration that optimizes manufacturing economics.

  1. How GNSS Enables Precision Farming

    Science.gov (United States)

    2014-12-01

    Precision farming: Feeding a Growing Population Enables Those Who Feed the World. Immediate and Ongoing Needs - population growth (more to feed) - urbanization (decrease in arable land) Double food production by 2050 to meet world demand. To meet thi...

  2. FROM PERSONALIZED TO PRECISION MEDICINE

    Directory of Open Access Journals (Sweden)

    K. V. Raskina

    2017-01-01

    Full Text Available The need to maintain a high quality of life against a backdrop of its inevitably increasing duration is one of the main problems of modern health care. The concept of "right drug to the right patient at the right time", which at first was bearing the name "personalized", is currently unanimously approved by international scientific community as "precision medicine". Precision medicine takes all the individual characteristics into account: genes diversity, environment, lifestyles, and even bacterial microflora and also involves the use of the latest technological developments, which serves to ensure that each patient gets assistance fitting his state best. In the United States, Canada and France national precision medicine programs have already been submitted and implemented. The aim of this review is to describe the dynamic integration of precision medicine methods into routine medical practice and life of modern society. The new paradigm prospects description are complemented by figures, proving the already achieved success in the application of precise methods for example, the targeted therapy of cancer. All in all, the presence of real-life examples, proving the regularity of transition to a new paradigm, and a wide range  of technical and diagnostic capabilities available and constantly evolving make the all-round transition to precision medicine almost inevitable.

  3. On-sky Closed-loop Correction of Atmospheric Dispersion for High-contrast Coronagraphy and Astrometry

    Science.gov (United States)

    Pathak, P.; Guyon, O.; Jovanovic, N.; Lozi, J.; Martinache, F.; Minowa, Y.; Kudo, T.; Kotani, T.; Takami, H.

    2018-02-01

    Adaptive optic (AO) systems delivering high levels of wavefront correction are now common at observatories. One of the main limitations to image quality after wavefront correction comes from atmospheric refraction. An atmospheric dispersion compensator (ADC) is employed to correct for atmospheric refraction. The correction is applied based on a look-up table consisting of dispersion values as a function of telescope elevation angle. The look-up table-based correction of atmospheric dispersion results in imperfect compensation leading to the presence of residual dispersion in the point spread function (PSF) and is insufficient when sub-milliarcsecond precision is required. The presence of residual dispersion can limit the achievable contrast while employing high-performance coronagraphs or can compromise high-precision astrometric measurements. In this paper, we present the first on-sky closed-loop correction of atmospheric dispersion by directly using science path images. The concept behind the measurement of dispersion utilizes the chromatic scaling of focal plane speckles. An adaptive speckle grid generated with a deformable mirror (DM) that has a sufficiently large number of actuators is used to accurately measure the residual dispersion and subsequently correct it by driving the ADC. We have demonstrated with the Subaru Coronagraphic Extreme AO (SCExAO) system on-sky closed-loop correction of residual dispersion to instruments which require sub-milliarcsecond correction.

  4. Nanomaterials for Cancer Precision Medicine.

    Science.gov (United States)

    Wang, Yilong; Sun, Shuyang; Zhang, Zhiyuan; Shi, Donglu

    2018-04-01

    Medical science has recently advanced to the point where diagnosis and therapeutics can be carried out with high precision, even at the molecular level. A new field of "precision medicine" has consequently emerged with specific clinical implications and challenges that can be well-addressed by newly developed nanomaterials. Here, a nanoscience approach to precision medicine is provided, with a focus on cancer therapy, based on a new concept of "molecularly-defined cancers." "Next-generation sequencing" is introduced to identify the oncogene that is responsible for a class of cancers. This new approach is fundamentally different from all conventional cancer therapies that rely on diagnosis of the anatomic origins where the tumors are found. To treat cancers at molecular level, a recently developed "microRNA replacement therapy" is applied, utilizing nanocarriers, in order to regulate the driver oncogene, which is the core of cancer precision therapeutics. Furthermore, the outcome of the nanomediated oncogenic regulation has to be accurately assessed by the genetically characterized, patient-derived xenograft models. Cancer therapy in this fashion is a quintessential example of precision medicine, presenting many challenges to the materials communities with new issues in structural design, surface functionalization, gene/drug storage and delivery, cell targeting, and medical imaging. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Precision Medicine and Men's Health.

    Science.gov (United States)

    Mata, Douglas A; Katchi, Farhan M; Ramasamy, Ranjith

    2017-07-01

    Precision medicine can greatly benefit men's health by helping to prevent, diagnose, and treat prostate cancer, benign prostatic hyperplasia, infertility, hypogonadism, and erectile dysfunction. For example, precision medicine can facilitate the selection of men at high risk for prostate cancer for targeted prostate-specific antigen screening and chemoprevention administration, as well as assist in identifying men who are resistant to medical therapy for prostatic hyperplasia, who may instead require surgery. Precision medicine-trained clinicians can also let couples know whether their specific cause of infertility should be bypassed by sperm extraction and in vitro fertilization to prevent abnormalities in their offspring. Though precision medicine's role in the management of hypogonadism has yet to be defined, it could be used to identify biomarkers associated with individual patients' responses to treatment so that appropriate therapy can be prescribed. Last, precision medicine can improve erectile dysfunction treatment by identifying genetic polymorphisms that regulate response to medical therapies and by aiding in the selection of patients for further cardiovascular disease screening.

  6. Precision Medicine in Gastrointestinal Pathology.

    Science.gov (United States)

    Wang, David H; Park, Jason Y

    2016-05-01

    -Precision medicine is the promise of individualized therapy and management of patients based on their personal biology. There are now multiple global initiatives to perform whole-genome sequencing on millions of individuals. In the United States, an early program was the Million Veteran Program, and a more recent proposal in 2015 by the president of the United States is the Precision Medicine Initiative. To implement precision medicine in routine oncology care, genetic variants present in tumors need to be matched with effective clinical therapeutics. When we focus on the current state of precision medicine for gastrointestinal malignancies, it becomes apparent that there is a mixed history of success and failure. -To present the current state of precision medicine using gastrointestinal oncology as a model. We will present currently available targeted therapeutics, promising new findings in clinical genomic oncology, remaining quality issues in genomic testing, and emerging oncology clinical trial designs. -Review of the literature including clinical genomic studies on gastrointestinal malignancies, clinical oncology trials on therapeutics targeted to molecular alterations, and emerging clinical oncology study designs. -Translating our ability to sequence thousands of genes into meaningful improvements in patient survival will be the challenge for the next decade.

  7. The solar neighborhood. XXXI. Discovery of an unusual red+white dwarf binary at ∼25 pc via astrometry and UV imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jao, Wei-Chun; Henry, Todd J.; Winters, Jennifer G.; Gies, Douglas R. [Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30302 (United States); Subasavage, John P. [US Naval Observatory, Flagstaff Station, 10391 West Naval Observatory Road, Flagstaff, AZ 86001 (United States); Riedel, Adric R. [Department of Physics and Astronomy, Hunter College, 695 Park Avenue, New York, NY 10065 (United States); Ianna, Philip A., E-mail: jao@chara.gsu.edu, E-mail: thenry@chara.gsu.edu, E-mail: winters@chara.gsu.edu, E-mail: gies@chara.gsu.edu, E-mail: jsubasavage@nofs.navy.mil, E-mail: ar494@hunter.cuny.edu, E-mail: philianna3@gmail.com [Department of Astronomy, University of Virginia, Charlottesville, VA 22904-4325 (United States)

    2014-01-01

    We report the discovery of a nearby M5.0V dwarf at 24.6 pc, SCR 1848–6855, that is orbited by an unusual companion causing an astrometric perturbation of more than 200 mas. This is by far the largest perturbation found to date among more than 700 targets observed during our long-term astrometry/photometry program at the CTIO 0.9 m telescope. We present here a suite of astrometric, photometric, and spectroscopic observations of this high proper motion (∼1.''3 yr{sup –1}) system in an effort to reveal the nature of this unusual binary. The measured near-UV and optical U band fluxes exceed those expected for comparable M5.0V stars, and excess flux is also detected in the spectral range 4000-7000 Å. The elusive companion has been detected in HST-STIS+MAMA images at 1820 Å and 2700 Å, and our analysis shows that it is probably a rare, cool, white dwarf with T = 4600-5500 K. Given the long-term astrometric coverage, the prospects for an accurate mass determination are excellent, although as yet we can only provide limits on the unusual companion's mass.

  8. Sensing technologies for precision irrigation

    CERN Document Server

    Ćulibrk, Dubravko; Minic, Vladan; Alonso Fernandez, Marta; Alvarez Osuna, Javier; Crnojevic, Vladimir

    2014-01-01

    This brief provides an overview of state-of-the-art sensing technologies relevant to the problem of precision irrigation, an emerging field within the domain of precision agriculture. Applications of wireless sensor networks, satellite data and geographic information systems in the domain are covered. This brief presents the basic concepts of the technologies and emphasizes the practical aspects that enable the implementation of intelligent irrigation systems. The authors target a broad audience interested in this theme and organize the content in five chapters, each concerned with a specific technology needed to address the problem of optimal crop irrigation. Professionals and researchers will find the text a thorough survey with practical applications.

  9. Precision measurement with atom interferometry

    International Nuclear Information System (INIS)

    Wang Jin

    2015-01-01

    Development of atom interferometry and its application in precision measurement are reviewed in this paper. The principle, features and the implementation of atom interferometers are introduced, the recent progress of precision measurement with atom interferometry, including determination of gravitational constant and fine structure constant, measurement of gravity, gravity gradient and rotation, test of weak equivalence principle, proposal of gravitational wave detection, and measurement of quadratic Zeeman shift are reviewed in detail. Determination of gravitational redshift, new definition of kilogram, and measurement of weak force with atom interferometry are also briefly introduced. (topical review)

  10. ELECTROWEAK PHYSICS AND PRECISION STUDIES

    International Nuclear Information System (INIS)

    MARCIANO, W.

    2005-01-01

    The utility of precision electroweak measurements for predicting the Standard Model Higgs mass via quantum loop effects is discussed. Current values of m W , sin 2 θ W (m Z ) # ovr MS# and m t imply a relatively light Higgs which is below the direct experimental bound but possibly consistent with Supersymmetry expectations. The existence of Supersymmetry is further suggested by a 2σ discrepancy between experiment and theory for the muon anomalous magnetic moment. Constraints from precision studies on other types of ''New Physics'' are also briefly described

  11. Universal precision sine bar attachment

    Science.gov (United States)

    Mann, Franklin D. (Inventor)

    1989-01-01

    This invention relates to an attachment for a sine bar which can be used to perform measurements during lathe operations or other types of machining operations. The attachment can be used for setting precision angles on vises, dividing heads, rotary tables and angle plates. It can also be used in the inspection of machined parts, when close tolerances are required, and in the layout of precision hardware. The novelty of the invention is believed to reside in a specific versatile sine bar attachment for measuring a variety of angles on a number of different types of equipment.

  12. Introduction to precise numerical methods

    CERN Document Server

    Aberth, Oliver

    2007-01-01

    Precise numerical analysis may be defined as the study of computer methods for solving mathematical problems either exactly or to prescribed accuracy. This book explains how precise numerical analysis is constructed. The book also provides exercises which illustrate points from the text and references for the methods presented. All disc-based content for this title is now available on the Web. · Clearer, simpler descriptions and explanations ofthe various numerical methods· Two new types of numerical problems; accurately solving partial differential equations with the included software and computing line integrals in the complex plane.

  13. STANFORD (SLAC): Precision electroweak result

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    Precision testing of the electroweak sector of the Standard Model has intensified with the recent publication* of results from the SLD collaboration's 1993 run on the Stanford Linear Collider, SLC. Using a highly polarized electron beam colliding with an unpolarized positron beam, SLD physicists measured the left-right asymmetry at the Z boson resonance with dramatically improved accuracy over 1992

  14. Spin and precision electroweak physics

    Energy Technology Data Exchange (ETDEWEB)

    Marciano, W.J. [Brookhaven National Lab., Upton, NY (United States)

    1994-12-01

    A perspective on fundamental parameters and precision tests of the Standard Model is given. Weak neutral current reactions are discussed with emphasis on those processes involving (polarized) electrons. The role of electroweak radiative corrections in determining the top quark mass and probing for {open_quotes}new physics{close_quotes} is described.

  15. Spin and precision electroweak physics

    International Nuclear Information System (INIS)

    Marciano, W.J.

    1993-01-01

    A perspective on fundamental parameters and precision tests of the Standard Model is given. Weak neutral current reactions are discussed with emphasis on those processes involving (polarized) electrons. The role of electroweak radiative corrections in determining the top quark mass and probing for ''new physics'' is described

  16. Precision surveying system for PEP

    International Nuclear Information System (INIS)

    Gunn, J.; Lauritzen, T.; Sah, R.; Pellisier, P.F.

    1977-01-01

    A semi-automatic precision surveying system is being developed for PEP. Reference elevations for vertical alignment will be provided by a liquid level. The short range surveying will be accomplished using a Laser Surveying System featuring automatic data acquisition and analysis

  17. Precision medicine at the crossroads.

    Science.gov (United States)

    Olson, Maynard V

    2017-10-11

    There are bioethical, institutional, economic, legal, and cultural obstacles to creating the robust-precompetitive-data resource that will be required to advance the vision of "precision medicine," the ability to use molecular data to target therapies to patients for whom they offer the most benefit at the least risk. Creation of such an "information commons" was the central recommendation of the 2011 report Toward Precision Medicine issued by a committee of the National Research Council of the USA (Committee on a Framework for Development of a New Taxonomy of Disease; National Research Council. Toward precision medicine: building a knowledge network for biomedical research and a new taxonomy of disease. 2011). In this commentary, I review the rationale for creating an information commons and the obstacles to doing so; then, I endorse a path forward based on the dynamic consent of research subjects interacting with researchers through trusted mediators. I assert that the advantages of the proposed system overwhelm alternative ways of handling data on the phenotypes, genotypes, and environmental exposures of individual humans; hence, I argue that its creation should be the central policy objective of early efforts to make precision medicine a reality.

  18. Proton gyromagnetic precision measurement system

    International Nuclear Information System (INIS)

    Zhu Deming; Deming Zhu

    1991-01-01

    A computerized control and measurement system used in the proton gyromagnetic precision meausrement is descirbed. It adopts the CAMAC data acquisition equipment, using on-line control and analysis with the HP85 and PDP-11/60 computer systems. It also adopts the RSX11M computer operation system, and the control software is written in FORTRAN language

  19. The usability of the optical parametric amplification of light for high-angular-resolution imaging and fast astrometry

    Science.gov (United States)

    Kurek, A. R.; Stachowski, A.; Banaszek, K.; Pollo, A.

    2018-05-01

    High-angular-resolution imaging is crucial for many applications in modern astronomy and astrophysics. The fundamental diffraction limit constrains the resolving power of both ground-based and spaceborne telescopes. The recent idea of a quantum telescope based on the optical parametric amplification (OPA) of light aims to bypass this limit for the imaging of extended sources by an order of magnitude or more. We present an updated scheme of an OPA-based device and a more accurate model of the signal amplification by such a device. The semiclassical model that we present predicts that the noise in such a system will form so-called light speckles as a result of light interference in the optical path. Based on this model, we analysed the efficiency of OPA in increasing the angular resolution of the imaging of extended targets and the precise localization of a distant point source. According to our new model, OPA offers a gain in resolved imaging in comparison to classical optics. For a given time-span, we found that OPA can be more efficient in localizing a single distant point source than classical telescopes.

  20. Precision and accuracy in radiotherapy

    International Nuclear Information System (INIS)

    Brenner, J.D.

    1989-01-01

    The required precision due to random errors in the delivery of fractionated dose regime is considered. It is argued that suggestions that 1-3% precision is needed may be unnecessarily conservative. It is further suggested that random and systematic errors should not be combined with equal weight to yield an overall target uncertainty in dose delivery, systematic errors being of greater significance. The authors conclude that imprecise dose delivery and inaccurate dose delivery affect patient-cure results differently. Whereas, for example, a 10% inaccuracy in dose delivery would be quite catastrophic in the case considered here, a corresponding imprecision would have a much smaller effect on overall success rates. (author). 14 refs.; 2 figs

  1. Precision electroweak physics at LEP

    Energy Technology Data Exchange (ETDEWEB)

    Mannelli, M.

    1994-12-01

    Copious event statistics, a precise understanding of the LEP energy scale, and a favorable experimental situation at the Z{sup 0} resonance have allowed the LEP experiments to provide both dramatic confirmation of the Standard Model of strong and electroweak interactions and to place substantially improved constraints on the parameters of the model. The author concentrates on those measurements relevant to the electroweak sector. It will be seen that the precision of these measurements probes sensitively the structure of the Standard Model at the one-loop level, where the calculation of the observables measured at LEP is affected by the value chosen for the top quark mass. One finds that the LEP measurements are consistent with the Standard Model, but only if the mass of the top quark is measured to be within a restricted range of about 20 GeV.

  2. Environment-assisted precision measurement

    DEFF Research Database (Denmark)

    Goldstein, G.; Cappellaro, P.; Maze, J. R.

    2011-01-01

    We describe a method to enhance the sensitivity of precision measurements that takes advantage of the environment of a quantum sensor to amplify the response of the sensor to weak external perturbations. An individual qubit is used to sense the dynamics of surrounding ancillary qubits, which...... are in turn affected by the external field to be measured. The resulting sensitivity enhancement is determined by the number of ancillas that are coupled strongly to the sensor qubit; it does not depend on the exact values of the coupling strengths and is resilient to many forms of decoherence. The method...... achieves nearly Heisenberg-limited precision measurement, using a novel class of entangled states. We discuss specific applications to improve clock sensitivity using trapped ions and magnetic sensing based on electronic spins in diamond...

  3. Precise object tracking under deformation

    International Nuclear Information System (INIS)

    Saad, M.H

    2010-01-01

    The precise object tracking is an essential issue in several serious applications such as; robot vision, automated surveillance (civil and military), inspection, biomedical image analysis, video coding, motion segmentation, human-machine interface, visualization, medical imaging, traffic systems, satellite imaging etc. This frame-work focuses on the precise object tracking under deformation such as scaling , rotation, noise, blurring and change of illumination. This research is a trail to solve these serious problems in visual object tracking by which the quality of the overall system will be improved. Developing a three dimensional (3D) geometrical model to determine the current pose of an object and predict its future location based on FIR model learned by the OLS. This framework presents a robust ranging technique to track a visual target instead of the traditional expensive ranging sensors. The presented research work is applied to real video stream and achieved high precession results.

  4. Fit to Electroweak Precision Data

    International Nuclear Information System (INIS)

    Erler, Jens

    2006-01-01

    A brief review of electroweak precision data from LEP, SLC, the Tevatron, and low energies is presented. The global fit to all data including the most recent results on the masses of the top quark and the W boson reinforces the preference for a relatively light Higgs boson. I will also give an outlook on future developments at the Tevatron Run II, CEBAF, the LHC, and the ILC

  5. Precise Object Tracking under Deformation

    International Nuclear Information System (INIS)

    Saad, M.H.

    2010-01-01

    The precise object tracking is an essential issue in several serious applications such as; robot vision, automated surveillance (civil and military), inspection, biomedical image analysis, video coding, motion segmentation, human-machine interface, visualization, medical imaging, traffic systems, satellite imaging etc. This framework focuses on the precise object tracking under deformation such as scaling, rotation, noise, blurring and change of illumination. This research is a trail to solve these serious problems in visual object tracking by which the quality of the overall system will be improved. Developing a three dimensional (3D) geometrical model to determine the current pose of an object and predict its future location based on FIR model learned by the OLS. This framework presents a robust ranging technique to track a visual target instead of the traditional expensive ranging sensors. The presented research work is applied to real video stream and achieved high precession results. xiiiThe precise object tracking is an essential issue in several serious applications such as; robot vision, automated surveillance (civil and military), inspection, biomedical image analysis, video coding, motion segmentation, human-machine interface, visualization, medical imaging, traffic systems, satellite imaging etc. This framework focuses on the precise object tracking under deformation such as scaling, rotation, noise, blurring and change of illumination. This research is a trail to solve these serious problems in visual object tracking by which the quality of the overall system will be improved. Developing a three dimensional (3D) geometrical model to determine the current pose of an object and predict its future location based on FIR model learned by the OLS. This framework presents a robust ranging technique to track a visual target instead of the traditional expensive ranging sensors. The presented research work is applied to real video stream and achieved high

  6. Precision measurements of electroweak parameters

    CERN Document Server

    Savin, Alexander

    2017-01-01

    A set of selected precise measurements of the SM parameters from the LHC experiments is discussed. Results on W-mass measurement and forward-backward asymmetry in production of the Drell--Yan events in both dielectron and dimuon decay channels are presented together with results on the effective mixing angle measurements. Electroweak production of the vector bosons in association with two jets is discussed.

  7. Precision titration mini-calorimeter

    International Nuclear Information System (INIS)

    Ensor, D.; Kullberg, L.; Choppin, G.

    1977-01-01

    The design and test of a small volume calorimeter of high precision and simple design is described. The calorimeter operates with solution sample volumes in the range of 3 to 5 ml. The results of experiments on the entropy changes for two standard reactions: (1) reaction of tris(hydroxymethyl)aminomethane with hydrochloric acid and (2) reaction between mercury(II) and bromide ions are reported to confirm the accuracy and overall performance of the calorimeter

  8. Knowledge of Precision Farming Beneficiaries

    Directory of Open Access Journals (Sweden)

    A.V. Greena

    2016-05-01

    Full Text Available Precision Farming is one of the many advanced farming practices that make production more efficient by better resource management and reducing wastage. TN-IAMWARM is a world bank funded project aims to improve the farm productivity and income through better water management. The present study was carried out in Kambainallur sub basin of Dharmapuri district with 120 TN-IAMWARM beneficiaries as respondents. The result indicated that more than three fourth (76.67 % of the respondents had high level of knowledge on precision farming technologies which was made possible by the implementation of TN-IAMWARM project. The study further revealed that educational status, occupational status and exposure to agricultural messages had a positive and significant contribution to the knowledge level of the respondents at 0.01 level of probability whereas experience in precision farming and social participation had a positive and significant contribution at 0.05 level of probability.

  9. Constraining supersymmetry with precision data

    International Nuclear Information System (INIS)

    Pierce, D.M.; Erler, J.

    1997-01-01

    We discuss the results of a global fit to precision data in supersymmetric models. We consider both gravity- and gauge-mediated models. As the superpartner spectrum becomes light, the global fit to the data typically results in larger values of χ 2 . We indicate the regions of parameter space which are excluded by the data. We discuss the additional effect of the B(B→X s γ) measurement. Our analysis excludes chargino masses below M Z in the simplest gauge-mediated model with μ>0, with stronger constraints for larger values of tanβ. copyright 1997 American Institute of Physics

  10. High precision Standard Model Physics

    International Nuclear Information System (INIS)

    Magnin, J.

    2009-01-01

    The main goal of the LHCb experiment, one of the four large experiments of the Large Hadron Collider, is to try to give answers to the question of why Nature prefers matter over antimatter? This will be done by studying the decay of b quarks and their antimatter partners, b-bar, which will be produced by billions in 14 TeV p-p collisions by the LHC. In addition, as 'beauty' particles mainly decay in charm particles, an interesting program of charm physics will be carried on, allowing to measure quantities as for instance the D 0 -D-bar 0 mixing, with incredible precision.

  11. Electroweak precision measurements in CMS

    CERN Document Server

    Dordevic, Milos

    2017-01-01

    An overview of recent results on electroweak precision measurements from the CMS Collaboration is presented. Studies of the weak boson differential transverse momentum spectra, Z boson angular coefficients, forward-backward asymmetry of Drell-Yan lepton pairs and charge asymmetry of W boson production are made in comparison to the state-of-the-art Monte Carlo generators and theoretical predictions. The results show a good agreement with the Standard Model. As a proof of principle for future W mass measurements, a W-like analysis of the Z boson mass is performed.

  12. Precision proton spectrometers for CMS

    CERN Document Server

    Albrow, Michael

    2013-01-01

    We plan to add high precision tracking- and timing-detectors at z = +/- 240 m to CMS to study exclusive processes p + p -- p + X + p at high luminosity. This enables the LHC to be used as a tagged photon-photon collider, with X = l+l- and W+W-, and as a "tagged" gluon-gluon collider (with a spectator gluon) for QCD studies with jets. A second stage at z = 240 m would allow observations of exclusive Higgs boson production.

  13. Precise Analysis of String Expressions

    DEFF Research Database (Denmark)

    Christensen, Aske Simon; Møller, Anders; Schwartzbach, Michael Ignatieff

    2003-01-01

    We perform static analysis of Java programs to answer a simple question: which values may occur as results of string expressions? The answers are summarized for each expression by a regular language that is guaranteed to contain all possible values. We present several applications of this analysis...... are automatically produced. We present extensive benchmarks demonstrating that the analysis is efficient and produces results of useful precision......., including statically checking the syntax of dynamically generated expressions, such as SQL queries. Our analysis constructs flow graphs from class files and generates a context-free grammar with a nonterminal for each string expression. The language of this grammar is then widened into a regular language...

  14. The Many Faces of Precision

    Directory of Open Access Journals (Sweden)

    Andy eClark

    2013-05-01

    Full Text Available An appreciation of the many roles of ‘precision-weighting’ (upping the gain on select populations of prediction error units opens the door to better accounts of planning and ‘offline simulation’, makes suggestive contact with large bodies of work on embodied and situated cognition, and offers new perspectives on the ‘active brain’. Combined with the complex affordances of language and culture, and operating against the essential backdrop of a variety of more biologically basic ploys and stratagems, the result is a maximally context-sensitive, restless, constantly self-reconfiguring architecture.

  15. Thin films for precision optics

    International Nuclear Information System (INIS)

    Araujo, J.F.; Maurici, N.; Castro, J.C. de

    1983-01-01

    The technology of producing dielectric and/or metallic thin films for high precision optical components is discussed. Computer programs were developed in order to calculate and register, graphically, reflectance and transmittance spectra of multi-layer films. The technology of vacuum evaporation of several materials was implemented in our thin-films laboratory; various films for optics were then developed. The possibility of first calculate film characteristics and then produce the film is of great advantage since it reduces the time required to produce a new type of film and also reduces the cost of the project. (C.L.B.) [pt

  16. Precision luminosity measurements at LHCb

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belous, Konstantin; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Bjørnstad, Pål Marius; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brambach, Tobias; Bressieux, Joël; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Brown, Henry; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Ciba, Krzystof; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Di Canto, Angelo; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gauld, Rhorry; Gavardi, Laura; Geraci, Angelo; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hunt, Philip; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jaton, Pierre; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kozlinskiy, Alexandr; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leo, Sabato; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lopez-March, Neus; Lowdon, Peter; Lu, Haiting; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martens, Aurelien; Martín Sánchez, Alexandra; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Oggero, Serena; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Otalora Goicochea, Juan Martin; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Perrin-Terrin, Mathieu; Pescatore, Luca; Pesen, Erhan; Pessina, Gianluigi; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schubiger, Maxime; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Sparkes, Ailsa; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Subbiah, Vijay Kartik; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wicht, Jean; Wiedner, Dirk; Wilkinson, Guy; Williams, Matthew; Williams, Mike; Wilschut, Hans; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang; Zvyagin, Alexander

    2014-12-05

    Measuring cross-sections at the LHC requires the luminosity to be determined accurately at each centre-of-mass energy $\\sqrt{s}$. In this paper results are reported from the luminosity calibrations carried out at the LHC interaction point 8 with the LHCb detector for $\\sqrt{s}$ = 2.76, 7 and 8 TeV (proton-proton collisions) and for $\\sqrt{s_{NN}}$ = 5 TeV (proton-lead collisions). Both the "van der Meer scan" and "beam-gas imaging" luminosity calibration methods were employed. It is observed that the beam density profile cannot always be described by a function that is factorizable in the two transverse coordinates. The introduction of a two-dimensional description of the beams improves significantly the consistency of the results. For proton-proton interactions at $\\sqrt{s}$ = 8 TeV a relative precision of the luminosity calibration of 1.47% is obtained using van der Meer scans and 1.43% using beam-gas imaging, resulting in a combined precision of 1.12%. Applying the calibration to the full data set determin...

  17. Laser precision microfabrication in Japan

    Science.gov (United States)

    Miyamoto, Isamu; Ooie, Toshihiko; Takeno, Shozui

    2000-11-01

    Electronic devices such as handy phones and micro computers have been rapidly expanding their market recent years due to their enhanced performance, down sizing and cost down. This has been realized by the innovation in the precision micro- fabrication technology of semiconductors and printed wiring circuit boards (PWB) where laser technologies such as lithography, drilling, trimming, welding and soldering play an important role. In phot lithography, for instance, KrF excimer lasers having a resolution of 0.18 micrometers has been used in production instead of mercury lamp. Laser drilling of PWB has been increased up to over 1000 holes per second, and approximately 800 laser drilling systems of PWB are expected to be delivered in the world market this year, and most of these laser processing systems are manufactured in Japan. Trend of laser micro-fabrication in Japanese industry is described along with recent topics of R&D, government supported project and future tasks of industrial laser precision micro-fabrication on the basis of the survey conducted by Japan laser Processing Society.

  18. Precision experiments in electroweak interactions

    International Nuclear Information System (INIS)

    Swartz, M.L.

    1990-03-01

    The electroweak theory of Glashow, Weinberg, and Salam (GWS) has become one of the twin pillars upon which our understanding of all particle physics phenomena rests. It is a brilliant achievement that qualitatively and quantitatively describes all of the vast quantity of experimental data that have been accumulated over some forty years. Note that the word quantitatively must be qualified. The low energy limiting cases of the GWS theory, Quantum Electrodynamics and the V-A Theory of Weak Interactions, have withstood rigorous testing. The high energy synthesis of these ideas, the GWS theory, has not yet been subjected to comparably precise scrutiny. The recent operation of a new generation of proton-antiproton (p bar p) and electron-positron (e + e - ) colliders has made it possible to produce and study large samples of the electroweak gauge bosons W ± and Z 0 . We expect that these facilities will enable very precise tests of the GWS theory to be performed in the near future. In keeping with the theme of this Institute, Physics at the 100 GeV Mass Scale, these lectures will explore the current status and the near-future prospects of these experiments

  19. Antihydrogen production and precision experiments

    International Nuclear Information System (INIS)

    Nieto, M.M.; Goldman, T.; Holzscheiter, M.H.

    1996-01-01

    The study of CPT invariance with the highest achievable precision in all particle sectors is of fundamental importance for physics. Equally important is the question of the gravitational acceleration of antimatter. In recent years, impressive progress has been achieved in capturing antiprotons in specially designed Penning traps, in cooling them to energies of a few milli-electron volts, and in storing them for hours in a small volume of space. Positrons have been accumulated in large numbers in similar traps, and low energy positron or positronium beams have been generated. Finally, steady progress has been made in trapping and cooling neutral atoms. Thus the ingredients to form antihydrogen at rest are at hand. Once antihydrogen atoms have been captured at low energy, spectroscopic methods can be applied to interrogate their atomic structure with extremely high precision and compare it to its normal matter counterpart, the hydrogen atom. Especially the 1S-2S transition, with a lifetime of the excited state of 122 msec and thereby a natural linewidth of 5 parts in 10 16 , offers in principle the possibility to directly compare matter and antimatter properties at a level of 1 part in 10 16

  20. Laser fusion and precision engineering

    International Nuclear Information System (INIS)

    Nakai, Sadao

    1989-01-01

    The development of laser nuclear fusion energy for attaining the self supply of energy in Japan and establishing the future perspective as the nation is based in the wide fields of high level science and technology. Therefore to its promotion, large expectation is placed as the powerful traction for the development of creative science and technology which are particularly necessary in Japan. The research on laser nuclear fusion advances steadily in the elucidation of the physics of pellet implosion which is its basic concept and compressed plasma parameters. In September, 1986, the number of neutron generation 10 13 , and in October, 1988, the high density compression 600 times as high as solid density have been achieved. Based on these results, now the laser nuclear fusion is in the situation to begin the attainment of ignition condition for nuclear fusion and the realization of break even. The optical components, high power laser technology, fuel pellet production, high resolution measurement, the simulation of implosion using a supercomputer and so on are closely related to precision engineering. In this report, the mechanism of laser nuclear fusion, the present status of its research, and the basic technologies and precision engineering are described. (K.I.)

  1. The Precision Field Lysimeter Concept

    Science.gov (United States)

    Fank, J.

    2009-04-01

    The understanding and interpretation of leaching processes have improved significantly during the past decades. Unlike laboratory experiments, which are mostly performed under very controlled conditions (e.g. homogeneous, uniform packing of pre-treated test material, saturated steady-state flow conditions, and controlled uniform hydraulic conditions), lysimeter experiments generally simulate actual field conditions. Lysimeters may be classified according to different criteria such as type of soil block used (monolithic or reconstructed), drainage (drainage by gravity or vacuum or a water table may be maintained), or weighing or non-weighing lysimeters. In 2004 experimental investigations have been set up to assess the impact of different farming systems on groundwater quality of the shallow floodplain aquifer of the river Mur in Wagna (Styria, Austria). The sediment is characterized by a thin layer (30 - 100 cm) of sandy Dystric Cambisol and underlying gravel and sand. Three precisely weighing equilibrium tension block lysimeters have been installed in agricultural test fields to compare water flow and solute transport under (i) organic farming, (ii) conventional low input farming and (iii) extensification by mulching grass. Specific monitoring equipment is used to reduce the well known shortcomings of lysimeter investigations: The lysimeter core is excavated as an undisturbed monolithic block (circular, 1 m2 surface area, 2 m depth) to prevent destruction of the natural soil structure, and pore system. Tracing experiments have been achieved to investigate the occurrence of artificial preferential flow and transport along the walls of the lysimeters. The results show that such effects can be neglected. Precisely weighing load cells are used to constantly determine the weight loss of the lysimeter due to evaporation and transpiration and to measure different forms of precipitation. The accuracy of the weighing apparatus is 0.05 kg, or 0.05 mm water equivalent

  2. Precision pharmacology for Alzheimer's disease.

    Science.gov (United States)

    Hampel, Harald; Vergallo, Andrea; Aguilar, Lisi Flores; Benda, Norbert; Broich, Karl; Cuello, A Claudio; Cummings, Jeffrey; Dubois, Bruno; Federoff, Howard J; Fiandaca, Massimo; Genthon, Remy; Haberkamp, Marion; Karran, Eric; Mapstone, Mark; Perry, George; Schneider, Lon S; Welikovitch, Lindsay A; Woodcock, Janet; Baldacci, Filippo; Lista, Simone

    2018-04-01

    The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant challenges for drug development. AD pathophysiology is progressing in a non-linear dynamic fashion across multiple systems levels - from molecules to organ systems - and through adaptation, to compensation, and decompensation to systems failure. Adaptation and compensation maintain homeostasis: a dynamic equilibrium resulting from the dynamic non-linear interaction between genome, epigenome, and environment. An individual vulnerability to stressors exists on the basis of individual triggers, drivers, and thresholds accounting for the initiation and failure of adaptive and compensatory responses. Consequently, the distinct pattern of AD pathophysiology in space and time must be investigated on the basis of the individual biological makeup. This requires the implementation of systems biology and neurophysiology to facilitate Precision Medicine (PM) and Precision Pharmacology (PP). The regulation of several processes at multiple levels of complexity from gene expression to cellular cycle to tissue repair and system-wide network activation has different time delays (temporal scale) according to the affected systems (spatial scale). The initial failure might originate and occur at every level potentially affecting the whole dynamic interrelated systems within an organism. Unraveling the spatial and temporal dynamics of non-linear pathophysiological mechanisms across the continuum of hierarchical self-organized systems levels and from systems homeostasis to systems failure is key to understand AD. Measuring and, possibly, controlling space- and time-scaled adaptive and compensatory responses occurring during AD will represent a crucial step to achieve the capacity to substantially modify the disease course and progression at the best suitable timepoints, thus counteracting disrupting critical pathophysiological inputs. This approach will provide the conceptual basis for effective

  3. Precision cosmology and the landscape

    International Nuclear Information System (INIS)

    Bousso, Raphael; Bousso, Raphael

    2006-01-01

    After reviewing the cosmological constant problem--why is Lambda not huge?--I outline the two basic approaches that had emerged by the late 1980s, and note that each made a clear prediction. Precision cosmological experiments now indicate that the cosmological constant is nonzero. This result strongly favors the environmental approach, in which vacuum energy can vary discretely among widely separated regions in the universe. The need to explain this variation from first principles constitutes an observational constraint on fundamental theory. I review arguments that string theory satisfies this constraint, as it contains a dense discretuum of metastable vacua. The enormous landscape of vacua calls for novel, statistical methods of deriving predictions, and it prompts us to reexamine our description of spacetime on the largest scales. I discuss the effects of cosmological dynamics, and I speculate that weighting vacua by their entropy production may allow for prior-free predictions that do not resort to explicitly anthropic arguments

  4. GPS Precision Timing at CERN

    CERN Document Server

    Beetham, C G

    1999-01-01

    For the past decade, the Global Positioning System (GPS) has been used to provide precise time, frequency and position co-ordinates world-wide. Recently, equipment has become available specialising in providing extremely accurate timing information, referenced to Universal Time Co-ordinates (UTC). This feature has been used at CERN to provide time of day information for systems that have been installed in the Proton Synchrotron (PS), Super Proton Synchrotron (SPS) and the Large Electron Positron (LEP) machines. The different systems are described as well as the planned developments, particularly with respect to optical transmission and the Inter-Range Instrumentation Group IRIG-B standard, for future use in the Large Hadron Collider (LHC).

  5. Development of sensor guided precision sprayers

    NARCIS (Netherlands)

    Nieuwenhuizen, A.T.; Zande, van de J.C.

    2013-01-01

    Sensor guided precision sprayers were developed to automate the spray process with a focus on emission reduction and identical or increased efficacy, with the precision agriculture concept in mind. Within the project “Innovations2” sensor guided precision sprayers were introduced to leek,

  6. Precision production: enabling deterministic throughput for precision aspheres with MRF

    Science.gov (United States)

    Maloney, Chris; Entezarian, Navid; Dumas, Paul

    2017-10-01

    Aspherical lenses offer advantages over spherical optics by improving image quality or reducing the number of elements necessary in an optical system. Aspheres are no longer being used exclusively by high-end optical systems but are now replacing spherical optics in many applications. The need for a method of production-manufacturing of precision aspheres has emerged and is part of the reason that the optics industry is shifting away from artisan-based techniques towards more deterministic methods. Not only does Magnetorheological Finishing (MRF) empower deterministic figure correction for the most demanding aspheres but it also enables deterministic and efficient throughput for series production of aspheres. The Q-flex MRF platform is designed to support batch production in a simple and user friendly manner. Thorlabs routinely utilizes the advancements of this platform and has provided results from using MRF to finish a batch of aspheres as a case study. We have developed an analysis notebook to evaluate necessary specifications for implementing quality control metrics. MRF brings confidence to optical manufacturing by ensuring high throughput for batch processing of aspheres.

  7. Precision measurements with atom interferometry

    Science.gov (United States)

    Schubert, Christian; Abend, Sven; Schlippert, Dennis; Ertmer, Wolfgang; Rasel, Ernst M.

    2017-04-01

    Interferometry with matter waves enables precise measurements of rotations, accelerations, and differential accelerations [1-5]. This is exploited for determining fundamental constants [2], in fundamental science as e.g. testing the universality of free fall [3], and is applied for gravimetry [4], and gravity gradiometry [2,5]. At the Institut für Quantenoptik in Hannover, different approaches are pursued. A large scale device is designed and currently being set up to investigate the gain in precision for gravimetry, gradiometry, and fundamental tests on large baselines [6]. For field applications, a compact and transportable device is being developed. Its key feature is an atom chip source providing a collimated high flux of atoms which is expected to mitigate systematic uncertainties [7,8]. The atom chip technology and miniaturization benefits from microgravity experiments in the drop tower in Bremen and sounding rocket experiments [8,9] which act as pathfinders for space borne operation [10]. This contribution will report about our recent results. The presented work is supported by the CRC 1227 DQ-mat, the CRC 1128 geo-Q, the RTG 1729, the QUEST-LFS, and by the German Space Agency (DLR) with funds provided by the Federal Ministry of Economic Affairs and Energy (BMWi) due to an enactment of the German Bundestag under Grant No. DLR 50WM1552-1557. [1] P. Berg et al., Phys. Rev. Lett., 114, 063002, 2015; I. Dutta et al., Phys. Rev. Lett., 116, 183003, 2016. [2] J. B. Fixler et al., Science 315, 74 (2007); G. Rosi et al., Nature 510, 518, 2014. [3] D. Schlippert et al., Phys. Rev. Lett., 112, 203002, 2014. [4] A. Peters et al., Nature 400, 849, 1999; A. Louchet-Chauvet et al., New J. Phys. 13, 065026, 2011; C. Freier et al., J. of Phys.: Conf. Series 723, 012050, 2016. [5] J. M. McGuirk et al., Phys. Rev. A 65, 033608, 2002; P. Asenbaum et al., arXiv:1610.03832. [6] J. Hartwig et al., New J. Phys. 17, 035011, 2015. [7] H. Ahlers et al., Phys. Rev. Lett. 116, 173601

  8. Precision is in their nature

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    There are more than 100 of them in the LHC ring and they have a total of about 400 degrees of freedom. Each one has 4 motors and the newest ones have their own beam-monitoring pickups. Their jaws constrain the relativistic, high-energy particles to a very small transverse area and protect the machine aperture. We are speaking about the LHC collimators, those ultra-precise instruments that leave escaping unstable particles no chance.   The internal structure of a new LHC collimator featuring (see red arrow) one of the beam position monitor's pickups. Designed at CERN but mostly produced by very specialised manufacturers in Europe, the LHC collimators are among the most complex elements of the accelerator. Their job is to control and safely dispose of the halo particles that are produced by unavoidable beam losses from the circulating beam core. “The LHC collimation system has been designed to ensure that beam losses in superconducting magnets remain below quench limits in al...

  9. The Age of Precision Cosmology

    Science.gov (United States)

    Chuss, David T.

    2012-01-01

    In the past two decades, our understanding of the evolution and fate of the universe has increased dramatically. This "Age of Precision Cosmology" has been ushered in by measurements that have both elucidated the details of the Big Bang cosmology and set the direction for future lines of inquiry. Our universe appears to consist of 5% baryonic matter; 23% of the universe's energy content is dark matter which is responsible for the observed structure in the universe; and 72% of the energy density is so-called "dark energy" that is currently accelerating the expansion of the universe. In addition, our universe has been measured to be geometrically flat to 1 %. These observations and related details of the Big Bang paradigm have hinted that the universe underwent an epoch of accelerated expansion known as Uinflation" early in its history. In this talk, I will review the highlights of modern cosmology, focusing on the contributions made by measurements of the cosmic microwave background, the faint afterglow of the Big Bang. I will also describe new instruments designed to measure the polarization of the cosmic microwave background in order to search for evidence of cosmic inflation.

  10. High precision redundant robotic manipulator

    International Nuclear Information System (INIS)

    Young, K.K.D.

    1998-01-01

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space is disclosed. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degrees of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns. 3 figs

  11. Studying antimatter with laser precision

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    The next generation of antihydrogen trapping devices, ALPHA-2, is moving into CERN’s Antiproton Decelerator (AD) hall. This brand-new experiment will allow the ALPHA collaboration to conduct studies of antimatter with greater precision. ALPHA spokesperson Jeffrey Hangst was recently awarded a grant by the Carlsberg Foundation, which will be used to purchase equipment for the new experiment.   A 3-D view of the new magnet (in blue) and cryostat. The red lines show the paths of laser beams. LHC-type current leads for the superconducting magnets are visible on the top-right of the image. The ALPHA collaboration has been working to trap and study antihydrogen since 2006. Using antiprotons provided by CERN’s Antiproton Decelerator (AD), ALPHA was the first experiment to trap antihydrogen and to hold it long enough to study its properties. “The new ALPHA-2 experiment will use integrated lasers to probe the trapped antihydrogen,” explains Jeffrey Hangst, ALP...

  12. High precision anatomy for MEG.

    Science.gov (United States)

    Troebinger, Luzia; López, José David; Lutti, Antoine; Bradbury, David; Bestmann, Sven; Barnes, Gareth

    2014-02-01

    Precise MEG estimates of neuronal current flow are undermined by uncertain knowledge of the head location with respect to the MEG sensors. This is either due to head movements within the scanning session or systematic errors in co-registration to anatomy. Here we show how such errors can be minimized using subject-specific head-casts produced using 3D printing technology. The casts fit the scalp of the subject internally and the inside of the MEG dewar externally, reducing within session and between session head movements. Systematic errors in matching to MRI coordinate system are also reduced through the use of MRI-visible fiducial markers placed on the same cast. Bootstrap estimates of absolute co-registration error were of the order of 1mm. Estimates of relative co-registration error were <1.5mm between sessions. We corroborated these scalp based estimates by looking at the MEG data recorded over a 6month period. We found that the between session sensor variability of the subject's evoked response was of the order of the within session noise, showing no appreciable noise due to between-session movement. Simulations suggest that the between-session sensor level amplitude SNR improved by a factor of 5 over conventional strategies. We show that at this level of coregistration accuracy there is strong evidence for anatomical models based on the individual rather than canonical anatomy; but that this advantage disappears for errors of greater than 5mm. This work paves the way for source reconstruction methods which can exploit very high SNR signals and accurate anatomical models; and also significantly increases the sensitivity of longitudinal studies with MEG. © 2013. Published by Elsevier Inc. All rights reserved.

  13. High precision anatomy for MEG☆

    Science.gov (United States)

    Troebinger, Luzia; López, José David; Lutti, Antoine; Bradbury, David; Bestmann, Sven; Barnes, Gareth

    2014-01-01

    Precise MEG estimates of neuronal current flow are undermined by uncertain knowledge of the head location with respect to the MEG sensors. This is either due to head movements within the scanning session or systematic errors in co-registration to anatomy. Here we show how such errors can be minimized using subject-specific head-casts produced using 3D printing technology. The casts fit the scalp of the subject internally and the inside of the MEG dewar externally, reducing within session and between session head movements. Systematic errors in matching to MRI coordinate system are also reduced through the use of MRI-visible fiducial markers placed on the same cast. Bootstrap estimates of absolute co-registration error were of the order of 1 mm. Estimates of relative co-registration error were < 1.5 mm between sessions. We corroborated these scalp based estimates by looking at the MEG data recorded over a 6 month period. We found that the between session sensor variability of the subject's evoked response was of the order of the within session noise, showing no appreciable noise due to between-session movement. Simulations suggest that the between-session sensor level amplitude SNR improved by a factor of 5 over conventional strategies. We show that at this level of coregistration accuracy there is strong evidence for anatomical models based on the individual rather than canonical anatomy; but that this advantage disappears for errors of greater than 5 mm. This work paves the way for source reconstruction methods which can exploit very high SNR signals and accurate anatomical models; and also significantly increases the sensitivity of longitudinal studies with MEG. PMID:23911673

  14. [Progress in precision medicine: a scientific perspective].

    Science.gov (United States)

    Wang, B; Li, L M

    2017-01-10

    Precision medicine is a new strategy for disease prevention and treatment by taking into account differences in genetics, environment and lifestyles among individuals and making precise diseases classification and diagnosis, which can provide patients with personalized, targeted prevention and treatment. Large-scale population cohort studies are fundamental for precision medicine research, and could produce best evidence for precision medicine practices. Current criticisms on precision medicine mainly focus on the very small proportion of benefited patients, the neglect of social determinants for health, and the possible waste of limited medical resources. In spite of this, precision medicine is still a most hopeful research area, and would become a health care practice model in the future.

  15. Precision Medicine, Cardiovascular Disease and Hunting Elephants.

    Science.gov (United States)

    Joyner, Michael J

    2016-01-01

    Precision medicine postulates improved prediction, prevention, diagnosis and treatment of disease based on patient specific factors especially DNA sequence (i.e., gene) variants. Ideas related to precision medicine stem from the much anticipated "genetic revolution in medicine" arising seamlessly from the human genome project (HGP). In this essay I deconstruct the concept of precision medicine and raise questions about the validity of the paradigm in general and its application to cardiovascular disease. Thus far precision medicine has underperformed based on the vision promulgated by enthusiasts. While niche successes for precision medicine are likely, the promises of broad based transformation should be viewed with skepticism. Open discussion and debate related to precision medicine are urgently needed to avoid misapplication of resources, hype, iatrogenic interventions, and distraction from established approaches with ongoing utility. Failure to engage in such debate will lead to negative unintended consequences from a revolution that might never come. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. New methods for precision Moeller polarimetry*

    International Nuclear Information System (INIS)

    Gaskell, D.; Meekins, D.G.; Yan, C.

    2007-01-01

    Precision electron beam polarimetry is becoming increasingly important as parity violation experiments attempt to probe the frontiers of the standard model. In the few GeV regime, Moeller polarimetry is well suited to high-precision measurements, however is generally limited to use at relatively low beam currents (<10 μA). We present a novel technique that will enable precision Moeller polarimetry at very large currents, up to 100 μA. (orig.)

  17. The Development of Precise Engineering Surveying Technology

    Directory of Open Access Journals (Sweden)

    LI Guangyun

    2017-10-01

    Full Text Available With the construction of big science projects in China, the precise engineering surveying technology developed rapidly in the 21th century. Firstly, the paper summarized up the current development situation for the precise engineering surveying instrument and theory. Then the three typical cases of the precise engineering surveying practice such as accelerator alignment, industry measurement and high-speed railway surveying technology are focused.

  18. Modeling and control of precision actuators

    CERN Document Server

    Kiong, Tan Kok

    2013-01-01

    IntroductionGrowing Interest in Precise ActuatorsTypes of Precise ActuatorsApplications of Precise ActuatorsNonlinear Dynamics and ModelingHysteresisCreepFrictionForce RipplesIdentification and Compensation of Preisach Hysteresis in Piezoelectric ActuatorsSVD-Based Identification and Compensation of Preisach HysteresisHigh-Bandwidth Identification and Compensation of Hysteretic Dynamics in Piezoelectric ActuatorsConcluding RemarksIdentification and Compensation of Frict

  19. Precision measurements at a muon collider

    International Nuclear Information System (INIS)

    Dawson, S.

    1995-01-01

    We discuss the potential for making precision measurements of M W and M T at a muon collider and the motivations for each measurement. A comparison is made with the precision measurements expected at other facilities. The measurement of the top quark decay width is also discussed

  20. Visual thread quality for precision miniature mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1981-04-01

    Threaded features have eight visual appearance factors which can affect their function in precision miniature mechanisms. The Bendix practice in deburring, finishing, and accepting these conditions on miniature threads is described as is their impact in assemblies of precision miniature electromechanical assemblies.

  1. Analysis of Precision of Activation Analysis Method

    DEFF Research Database (Denmark)

    Heydorn, Kaj; Nørgaard, K.

    1973-01-01

    The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T...

  2. An aberrant precision account of autism.

    Directory of Open Access Journals (Sweden)

    Rebecca P Lawson

    2014-05-01

    Full Text Available Autism is a neurodevelopmental disorder characterised by problems with social-communication, restricted interests and repetitive behaviour. A recent and controversial article presented a compelling normative explanation for the perceptual symptoms of autism in terms of a failure of Bayesian inference (Pellicano and Burr, 2012. In response, we suggested that when Bayesian interference is grounded in its neural instantiation – namely, predictive coding – many features of autistic perception can be attributed to aberrant precision (or beliefs about precision within the context of hierarchical message passing in the brain (Friston et al., 2013. Here, we unpack the aberrant precision account of autism. Specifically, we consider how empirical findings – that speak directly or indirectly to neurobiological mechanisms – are consistent with the aberrant encoding of precision in autism; in particular, an imbalance of the precision ascribed to sensory evidence relative to prior beliefs.

  3. Precision medicine for psychopharmacology: a general introduction.

    Science.gov (United States)

    Shin, Cheolmin; Han, Changsu; Pae, Chi-Un; Patkar, Ashwin A

    2016-07-01

    Precision medicine is an emerging medical model that can provide accurate diagnoses and tailored therapeutic strategies for patients based on data pertaining to genes, microbiomes, environment, family history and lifestyle. Here, we provide basic information about precision medicine and newly introduced concepts, such as the precision medicine ecosystem and big data processing, and omics technologies including pharmacogenomics, pharamacometabolomics, pharmacoproteomics, pharmacoepigenomics, connectomics and exposomics. The authors review the current state of omics in psychiatry and the future direction of psychopharmacology as it moves towards precision medicine. Expert commentary: Advances in precision medicine have been facilitated by achievements in multiple fields, including large-scale biological databases, powerful methods for characterizing patients (such as genomics, proteomics, metabolomics, diverse cellular assays, and even social networks and mobile health technologies), and computer-based tools for analyzing large amounts of data.

  4. Precision surveying the principles and geomatics practice

    CERN Document Server

    Ogundare, John Olusegun

    2016-01-01

    A comprehensive overview of high precision surveying, including recent developments in geomatics and their applications This book covers advanced precision surveying techniques, their proper use in engineering and geoscience projects, and their importance in the detailed analysis and evaluation of surveying projects. The early chapters review the fundamentals of precision surveying: the types of surveys; survey observations; standards and specifications; and accuracy assessments for angle, distance and position difference measurement systems. The book also covers network design and 3-D coordinating systems before discussing specialized topics such as structural and ground deformation monitoring techniques and analysis, mining surveys, tunneling surveys, and alignment surveys. Precision Surveying: The Principles and Geomatics Practice: * Covers structural and ground deformation monitoring analysis, advanced techniques in mining and tunneling surveys, and high precision alignment of engineering structures *...

  5. Toward precision medicine in Alzheimer's disease.

    Science.gov (United States)

    Reitz, Christiane

    2016-03-01

    In Western societies, Alzheimer's disease (AD) is the most common form of dementia and the sixth leading cause of death. In recent years, the concept of precision medicine, an approach for disease prevention and treatment that is personalized to an individual's specific pattern of genetic variability, environment and lifestyle factors, has emerged. While for some diseases, in particular select cancers and a few monogenetic disorders such as cystic fibrosis, significant advances in precision medicine have been made over the past years, for most other diseases precision medicine is only in its beginning. To advance the application of precision medicine to a wider spectrum of disorders, governments around the world are starting to launch Precision Medicine Initiatives, major efforts to generate the extensive scientific knowledge needed to integrate the model of precision medicine into every day clinical practice. In this article we summarize the state of precision medicine in AD, review major obstacles in its development, and discuss its benefits in this highly prevalent, clinically and pathologically complex disease.

  6. [Precision Nursing: Individual-Based Knowledge Translation].

    Science.gov (United States)

    Chiang, Li-Chi; Yeh, Mei-Ling; Su, Sui-Lung

    2016-12-01

    U.S. President Obama announced a new era of precision medicine in the Precision Medicine Initiative (PMI). This initiative aims to accelerate the progress of personalized medicine in light of individual requirements for prevention and treatment in order to improve the state of individual and public health. The recent and dramatic development of large-scale biologic databases (such as the human genome sequence), powerful methods for characterizing patients (such as genomics, microbiome, diverse biomarkers, and even pharmacogenomics), and computational tools for analyzing big data are maximizing the potential benefits of precision medicine. Nursing science should follow and keep pace with this trend in order to develop empirical knowledge and expertise in the area of personalized nursing care. Nursing scientists must encourage, examine, and put into practice innovative research on precision nursing in order to provide evidence-based guidance to clinical practice. The applications in personalized precision nursing care include: explanations of personalized information such as the results of genetic testing; patient advocacy and support; anticipation of results and treatment; ongoing chronic monitoring; and support for shared decision-making throughout the disease trajectory. Further, attention must focus on the family and the ethical implications of taking a personalized approach to care. Nurses will need to embrace the paradigm shift to precision nursing and work collaboratively across disciplines to provide the optimal personalized care to patients. If realized, the full potential of precision nursing will provide the best chance for good health for all.

  7. Advances in Precision Medicine: Tailoring Individualized Therapies.

    Science.gov (United States)

    Matchett, Kyle B; Lynam-Lennon, Niamh; Watson, R William; Brown, James A L

    2017-10-25

    The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.

  8. Mixed-Precision Spectral Deferred Correction: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Grout, Ray W. S.

    2015-09-02

    Convergence of spectral deferred correction (SDC), where low-order time integration methods are used to construct higher-order methods through iterative refinement, can be accelerated in terms of computational effort by using mixed-precision methods. Using ideas from multi-level SDC (in turn based on FAS multigrid ideas), some of the SDC correction sweeps can use function values computed in reduced precision without adversely impacting the accuracy of the final solution. This is particularly beneficial for the performance of combustion solvers such as S3D [6] which require double precision accuracy but are performance limited by the cost of data motion.

  9. Accuracy and precision in thermoluminescence dosimetry

    International Nuclear Information System (INIS)

    Marshall, T.O.

    1984-01-01

    The question of accuracy and precision in thermoluminescent dosimetry, particularly in relation to lithium fluoride phosphor, is discussed. The more important sources of error, including those due to the detectors, the reader, annealing and dosemeter design, are identified and methods of reducing their effects on accuracy and precision to a minimum are given. Finally, the accuracy and precision achievable for three quite different applications are discussed, namely, for personal dosimetry, environmental monitoring and for the measurement of photon dose distributions in phantoms. (U.K.)

  10. High - speed steel for precise cased tools

    International Nuclear Information System (INIS)

    Karwiarz, J.; Mazur, A.

    2001-01-01

    The test results of high-vanadium high - speed steel (SWV9) for precise casted tools are presented. The face -milling cutters of NFCa80A type have been tested in industrial operating conditions. An average life - time of SWV9 steel tools was 3-10 times longer compare to the conventional high - speed milling cutters. Metallography of SWB9 precise casted steel revealed beneficial for tool properties distribution of primary vanadium carbides in the steel matrix. Presented results should be a good argument for wide application of high - vanadium high - speed steel for precise casted tools. (author)

  11. Precision mechatronics based on high-precision measuring and positioning systems and machines

    Science.gov (United States)

    Jäger, Gerd; Manske, Eberhard; Hausotte, Tino; Mastylo, Rostyslav; Dorozhovets, Natalja; Hofmann, Norbert

    2007-06-01

    Precision mechatronics is defined in the paper as the science and engineering of a new generation of high precision systems and machines. Nanomeasuring and nanopositioning engineering represents important fields of precision mechatronics. The nanometrology is described as the today's limit of the precision engineering. The problem, how to design nanopositioning machines with uncertainties as small as possible will be discussed. The integration of several optical and tactile nanoprobes makes the 3D-nanopositioning machine suitable for various tasks, such as long range scanning probe microscopy, mask and wafer inspection, nanotribology, nanoindentation, free form surface measurement as well as measurement of microoptics, precision molds, microgears, ring gauges and small holes.

  12. High precision spectrophotometric analysis of thorium

    International Nuclear Information System (INIS)

    Palmieri, H.E.L.

    1984-01-01

    An accurate and precise determination of thorium is proposed. Precision of about 0,1% is required for the determination of macroquantities of thorium when processed. After an extensive literature search concerning this subject, spectrophotometric titration has been chosen, using dissodium ethylenediaminetetraacetate (EDTA) solution and alizarin-S as indicator. In order to obtain such a precision, an amount of 0,025 M EDTA solution precisely measured has been added and the titration was completed with less than 5 ml of 0,0025 M EDTA solution. It is usual to locate the end-point graphically, by plotting added titrant versus absorbance. The non-linear minimum square fit, using the Fletcher e Powell's minimization process and a computer programme. Besides the equivalence point, other parameters of titration were determined: the indicator concentration, the absorbance of the metal-indicator complex, and the stability constants of the metal-indicator and the metal-EDTA complexes. (Author) [pt

  13. Thorium spectrophotometric analysis with high precision

    International Nuclear Information System (INIS)

    Palmieri, H.E.L.

    1983-06-01

    An accurate and precise determination of thorium is proposed. Precision of about 0,1% is required for the determination of macroquantities of thorium processed. After an extensive literature search concerning this subject, spectrophotometric titration has been chosen, using disodium ethylenediaminetetraacetate (EDTA) solution and alizarin S as indicator. In order to obtain such a precision, an amount of 0,025 M EDTA solution precisely measured has been added and the titration was completed with less than 5 ml of 0,0025 M EDTA solution. It is usual to locate the end-point graphically, by plotting added titrant versus absorbance. The non-linear minimum square fit, using the Fletcher e Powell's minimization process and a computer program. (author)

  14. Cardiovascular Precision Medicine in the Genomics Era

    Directory of Open Access Journals (Sweden)

    Alexandra M. Dainis, BS

    2018-04-01

    Full Text Available Summary: Precision medicine strives to delineate disease using multiple data sources—from genomics to digital health metrics—in order to be more precise and accurate in our diagnoses, definitions, and treatments of disease subtypes. By defining disease at a deeper level, we can treat patients based on an understanding of the molecular underpinnings of their presentations, rather than grouping patients into broad categories with one-size-fits-all treatments. In this review, the authors examine how precision medicine, specifically that surrounding genetic testing and genetic therapeutics, has begun to make strides in both common and rare cardiovascular diseases in the clinic and the laboratory, and how these advances are beginning to enable us to more effectively define risk, diagnose disease, and deliver therapeutics for each individual patient. Key Words: genome sequencing, genomics, precision medicine, targeted therapeutics

  15. Equity and Value in 'Precision Medicine'.

    Science.gov (United States)

    Gray, Muir; Lagerberg, Tyra; Dombrádi, Viktor

    2017-04-01

    Precision medicine carries huge potential in the treatment of many diseases, particularly those with high-penetrance monogenic underpinnings. However, precision medicine through genomic technologies also has ethical implications. We will define allocative, personal, and technical value ('triple value') in healthcare and how this relates to equity. Equity is here taken to be implicit in the concept of triple value in countries that have publicly funded healthcare systems. It will be argued that precision medicine risks concentrating resources to those that already experience greater access to healthcare and power in society, nationally as well as globally. Healthcare payers, clinicians, and patients must all be involved in optimising the potential of precision medicine, without reducing equity. Throughout, the discussion will refer to the NHS RightCare Programme, which is a national initiative aiming to improve value and equity in the context of NHS England.

  16. The forthcoming era of precision medicine.

    Science.gov (United States)

    Gamulin, Stjepan

    2016-11-01

    The aim of this essay is to present the definition and principles of personalized or precision medicine, the perspective and barriers to its development and clinical application. The implementation of precision medicine in health care requires the coordinated efforts of all health care stakeholders (the biomedical community, government, regulatory bodies, patients' groups). Particularly, translational research with the integration of genomic and comprehensive data from all levels of the organism ("big data"), development of bioinformatics platforms enabling network analysis of disease etiopathogenesis, development of a legislative framework for handling personal data, and new paradigms of medical education are necessary for successful application of the concept of precision medicine in health care. In the present and future era of precision medicine, the collaboration of all participants in health care is necessary for its realization, resulting in improvement of diagnosis, prevention and therapy, based on a holistic, individually tailored approach. Copyright © 2016 by Academy of Sciences and Arts of Bosnia and Herzegovina.

  17. Epistemology, Ethics, and Progress in Precision Medicine.

    Science.gov (United States)

    Hey, Spencer Phillips; Barsanti-Innes, Brianna

    2016-01-01

    The emerging paradigm of precision medicine strives to leverage the tools of molecular biology to prospectively tailor treatments to the individual patient. Fundamental to the success of this movement is the discovery and validation of "predictive biomarkers," which are properties of a patient's biological specimens that can be assayed in advance of therapy to inform the treatment decision. Unfortunately, research into biomarkers and diagnostics for precision medicine has fallen well short of expectations. In this essay, we examine the portfolio of research activities into the excision repair cross complement group 1 (ERCC1) gene as a predictive biomarker for precision lung cancer therapy as a case study in elucidating the epistemological and ethical obstacles to developing new precision medicines.

  18. A Note on "Accuracy" and "Precision"

    Science.gov (United States)

    Stallings, William M.; Gillmore, Gerald M.

    1971-01-01

    Advocates the use of precision" rather than accuracy" in defining reliability. These terms are consistently differentiated in certain sciences. Review of psychological and measurement literature reveals, however, interchangeable usage of the terms in defining reliability. (Author/GS)

  19. Precision axial translator with high stability.

    Science.gov (United States)

    Bösch, M A

    1979-08-01

    We describe a new type of translator which is inherently stable against torsion and twisting. This concentric translator is also ideally suited for precise axial motion with clearance of the center line.

  20. Mechanics and Physics of Precise Vacuum Mechanisms

    CERN Document Server

    Deulin, E. A; Panfilov, Yu V; Nevshupa, R. A

    2010-01-01

    In this book the Russian expertise in the field of the design of precise vacuum mechanics is summarized. A wide range of physical applications of mechanism design in electronic, optical-electronic, chemical, and aerospace industries is presented in a comprehensible way. Topics treated include the method of microparticles flow regulation and its determination in vacuum equipment and mechanisms of electronics; precise mechanisms of nanoscale precision based on magnetic and electric rheology; precise harmonic rotary and not-coaxial nut-screw linear motion vacuum feedthroughs with technical parameters considered the best in the world; elastically deformed vacuum motion feedthroughs without friction couples usage; the computer system of vacuum mechanisms failure predicting. This English edition incorporates a number of features which should improve its usefulness as a textbook without changing the basic organization or the general philosophy of presentation of the subject matter of the original Russian work. Exper...

  1. Precision Munition Electro-Sciences Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility allows the characterization of the electro-magnetic environment produced by a precision weapon in free flight. It can measure the radiofrequency (RF)...

  2. Precision electroweak physics at the Tevatron

    International Nuclear Information System (INIS)

    James, Eric B.

    2006-01-01

    An overview of Tevatron electroweak measurements performed by the CDF and Dφ experiments is presented. The current status and future prospects for high precision measurements of electroweak parameters and detailed studies of boson production are highlighted. (author)

  3. Precision Guidance with Impact Angle Requirements

    National Research Council Canada - National Science Library

    Ford, Jason

    2001-01-01

    This paper examines a weapon system precision guidance problem in which the objective is to guide a weapon onto a non-manoeuvring target so that a particular desired angle of impact is achieved using...

  4. Precise subtyping for synchronous multiparty sessions

    Directory of Open Access Journals (Sweden)

    Mariangiola Dezani-Ciancaglini

    2016-02-01

    Full Text Available The notion of subtyping has gained an important role both in theoretical and applicative domains: in lambda and concurrent calculi as well as in programming languages. The soundness and the completeness, together referred to as the preciseness of subtyping, can be considered from two different points of view: operational and denotational. The former preciseness has been recently developed with respect to type safety, i.e. the safe replacement of a term of a smaller type when a term of a bigger type is expected. The latter preciseness is based on the denotation of a type which is a mathematical object that describes the meaning of the type in accordance with the denotations of other expressions from the language. The result of this paper is the operational and denotational preciseness of the subtyping for a synchronous multiparty session calculus. The novelty of this paper is the introduction of characteristic global types to prove the operational completeness.

  5. Prospects for Precision Neutrino Cross Section Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Harris, Deborah A. [Fermilab

    2016-01-28

    The need for precision cross section measurements is more urgent now than ever before, given the central role neutrino oscillation measurements play in the field of particle physics. The definition of precision is something worth considering, however. In order to build the best model for an oscillation experiment, cross section measurements should span a broad range of energies, neutrino interaction channels, and target nuclei. Precision might better be defined not in the final uncertainty associated with any one measurement but rather with the breadth of measurements that are available to constrain models. Current experience shows that models are better constrained by 10 measurements across different processes and energies with 10% uncertainties than by one measurement of one process on one nucleus with a 1% uncertainty. This article describes the current status of and future prospects for the field of precision cross section measurements considering the metric of how many processes, energies, and nuclei have been studied.

  6. Precise Calculation of Complex Radioactive Decay Chains

    National Research Council Canada - National Science Library

    Harr, Logan J

    2007-01-01

    ...). An application of the exponential moments function is used with a transmutation matrix in the calculation of complex radioactive decay chains to achieve greater precision than can be attained through current methods...

  7. Collaborative Genomics Study Advances Precision Oncology

    Science.gov (United States)

    A collaborative study conducted by two Office of Cancer Genomics (OCG) initiatives highlights the importance of integrating structural and functional genomics programs to improve cancer therapies, and more specifically, contribute to precision oncology treatments for children.

  8. Nucleon measurements at the precision frontier

    Energy Technology Data Exchange (ETDEWEB)

    Carlson, Carl E. [Physics Department, College of William and Mary, Williamsburg, VA 23187 (United States)

    2013-11-07

    We comment on nucleon measurements at the precision frontier. As examples of what can be learned, we concentrate on three topics, which are parity violating scattering experiments, the proton radius puzzle, and the symbiosis between nuclear and atomic physics.

  9. The forthcoming era of precision medicine

    Directory of Open Access Journals (Sweden)

    Stjepan Gamulin

    2016-11-01

    Full Text Available Abstract. The aim of this essay is to present the definition and principles of personalized or precision medicine, the perspective and barriers to its development and clinical application. The implementation of precision medicine in health care requires the coordinated efforts of all health care stakeholders (the biomedical community, government, regulatory bodies, patients’ groups. Particularly, translational research with the integration of genomic and comprehensive data from all levels of the organism (“big data”, development of bioinformatics platforms enabling network analysis of disease etiopathogenesis, development of a legislative framework for handling personal data, and new paradigms of medical education are necessary for successful application of the concept of precision medicine in health care. Conclusion. In the present and future era of precision medicine, the collaboration of all participants in health care is necessary for its realization, resulting in improvement of diagnosis, prevention and therapy, based on a holistic, individually tailored approach.

  10. PRECISION ELECTROWEAK MEASUREMENTS AND THE HIGGS MASS

    International Nuclear Information System (INIS)

    MARCIANO, W.J.

    2004-01-01

    The utility of precision electroweak measurements for predicting the Standard Model Higgs mass via quantum loop effects is discussed. Current constraints from m w and sin 2 θ w (m z ) ovr MS imply a relatively light Higgs ∼< 154 GeV which is consistent with Supersymmetry expectations. The existence of Supersymmetry is further suggested by a discrepancy between experiment and theory for the muon anomalous magnetic moment. Constraints from precision studies on other types of ''New Physics'' are also briefly described

  11. Precision Medicine-Nobody Is Average.

    Science.gov (United States)

    Vinks, A A

    2017-03-01

    Medicine gets personal and tailor-made treatments are underway. Hospitals have started to advertise their advanced genomic testing capabilities and even their disruptive technologies to help foster a culture of innovation. The prediction in the lay press is that in decades from now we may look back and see 2017 as the year precision medicine blossomed. It is all part of the Precision Medicine Initiative that takes into account individual differences in people's genes, environments, and lifestyles. © 2017 ASCPT.

  12. The role of precise time in IFF

    Science.gov (United States)

    Bridge, W. M.

    1982-01-01

    The application of precise time to the identification of friend or foe (IFF) problem is discussed. The simple concept of knowing when to expect each signal is exploited in a variety of ways to achieve an IFF system which is hard to detect, minimally exploitable and difficult to jam. Precise clocks are the backbone of the concept and the various candidates for this role are discussed. The compact rubidium-controlled oscillator is the only practical candidate.

  13. Precision siting of a particle accelerator

    International Nuclear Information System (INIS)

    Cintra, Jorge Pimentel

    1996-01-01

    Precise location is a specific survey job that involves a high skilled work to avoid unrecoverable results at the project installation. As a function of the different process stages, different specifications can be applied, invoking different instruments: theodolite, measurement tape, distanciometer, invar wire. This paper, based on experience obtained at the installation of particle accelerator equipment, deals with general principles of precise location: tolerance definitions, increasing accuracy techniques, schedule of locations, sensitivity analysis, quality control methods. (author)

  14. Principles of precision medicine in stroke.

    Science.gov (United States)

    Hinman, Jason D; Rost, Natalia S; Leung, Thomas W; Montaner, Joan; Muir, Keith W; Brown, Scott; Arenillas, Juan F; Feldmann, Edward; Liebeskind, David S

    2017-01-01

    The era of precision medicine has arrived and conveys tremendous potential, particularly for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and path to recovery are populated by a series of highly individualised questions. Moreover, the phenotypic complexity of a clinical diagnosis of stroke makes a simple genetic risk assessment only partially informative on an individual basis. The guiding principles of precision medicine in stroke underscore the need to identify, value, organise and analyse the multitude of variables obtained from each individual to generate a precise approach to optimise cerebrovascular health. Existing data may be leveraged with novel technologies, informatics and practical clinical paradigms to apply these principles in stroke and realise the promise of precision medicine. Importantly, precision medicine in stroke will only be realised once efforts to collect, value and synthesise the wealth of data collected in clinical trials and routine care starts. Stroke theranostics, the ultimate vision of synchronising tailored therapeutic strategies based on specific diagnostic data, demand cerebrovascular expertise on big data approaches to clinically relevant paradigms. This review considers such challenges and delineates the principles on a roadmap for rational application of precision medicine to stroke and cerebrovascular health. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  15. Precision medicine needs pioneering clinical bioinformaticians.

    Science.gov (United States)

    Gómez-López, Gonzalo; Dopazo, Joaquín; Cigudosa, Juan C; Valencia, Alfonso; Al-Shahrour, Fátima

    2017-10-25

    Success in precision medicine depends on accessing high-quality genetic and molecular data from large, well-annotated patient cohorts that couple biological samples to comprehensive clinical data, which in conjunction can lead to effective therapies. From such a scenario emerges the need for a new professional profile, an expert bioinformatician with training in clinical areas who can make sense of multi-omics data to improve therapeutic interventions in patients, and the design of optimized basket trials. In this review, we first describe the main policies and international initiatives that focus on precision medicine. Secondly, we review the currently ongoing clinical trials in precision medicine, introducing the concept of 'precision bioinformatics', and we describe current pioneering bioinformatics efforts aimed at implementing tools and computational infrastructures for precision medicine in health institutions around the world. Thirdly, we discuss the challenges related to the clinical training of bioinformaticians, and the urgent need for computational specialists capable of assimilating medical terminologies and protocols to address real clinical questions. We also propose some skills required to carry out common tasks in clinical bioinformatics and some tips for emergent groups. Finally, we explore the future perspectives and the challenges faced by precision medicine bioinformatics. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  16. Towards precision medicine; a new biomedical cosmology.

    Science.gov (United States)

    Vegter, M W

    2018-02-10

    Precision Medicine has become a common label for data-intensive and patient-driven biomedical research. Its intended future is reflected in endeavours such as the Precision Medicine Initiative in the USA. This article addresses the question whether it is possible to discern a new 'medical cosmology' in Precision Medicine, a concept that was developed by Nicholas Jewson to describe comprehensive transformations involving various dimensions of biomedical knowledge and practice, such as vocabularies, the roles of patients and physicians and the conceptualisation of disease. Subsequently, I will elaborate my assessment of the features of Precision Medicine with the help of Michel Foucault, by exploring how precision medicine involves a transformation along three axes: the axis of biomedical knowledge, of biomedical power and of the patient as a self. Patients are encouraged to become the managers of their own health status, while the medical domain is reframed as a data-sharing community, characterised by changing power relationships between providers and patients, producers and consumers. While the emerging Precision Medicine cosmology may surpass existing knowledge frameworks; it obscures previous traditions and reduces research-subjects to mere data. This in turn, means that the individual is both subjected to the neoliberal demand to share personal information, and at the same time has acquired the positive 'right' to become a member of the data-sharing community. The subject has to constantly negotiate the meaning of his or her data, which can either enable self-expression, or function as a commanding Superego.

  17. Precision oncology: origins, optimism, and potential.

    Science.gov (United States)

    Prasad, Vinay; Fojo, Tito; Brada, Michael

    2016-02-01

    Imatinib, the first and arguably the best targeted therapy, became the springboard for developing drugs aimed at molecular targets deemed crucial to tumours. As this development unfolded, a revolution in the speed and cost of genetic sequencing occurred. The result--an armamentarium of drugs and an array of molecular targets--set the stage for precision oncology, a hypothesis that cancer treatment could be markedly improved if therapies were guided by a tumour's genomic alterations. Drawing lessons from the biological basis of cancer and recent empirical investigations, we take a more measured view of precision oncology's promise. Ultimately, the promise is not our concern, but the threshold at which we declare success. We review reports of precision oncology alongside those of precision diagnostics and novel radiotherapy approaches. Although confirmatory evidence is scarce, these interventions have been widely endorsed. We conclude that the current path will probably not be successful or, at a minimum, will have to undergo substantive adjustments before it can be successful. For the sake of patients with cancer, we hope one form of precision oncology will deliver on its promise. However, until confirmatory studies are completed, precision oncology remains unproven, and as such, a hypothesis in need of rigorous testing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Precision validation of MIPAS-Envisat products

    Directory of Open Access Journals (Sweden)

    C. Piccolo

    2007-01-01

    Full Text Available This paper discusses the variation and validation of the precision, or estimated random error, associated with the ESA Level 2 products from the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS. This quantity represents the propagation of the radiometric noise from the spectra through the retrieval process into the Level 2 profile values. The noise itself varies with time, steadily rising between ice decontamination events, but the Level 2 precision has a greater variation due to the atmospheric temperature which controls the total radiance received. Hence, for all species, the precision varies latitudinally/seasonally with temperature, with a small superimposed temporal structure determined by the degree of ice contamination on the detectors. The precision validation involves comparing two MIPAS retrievals at the intersections of ascending/descending orbits. For 5 days per month of full resolution MIPAS operation, the standard deviation of the matching profile pairs is computed and compared with the precision given in the MIPAS Level 2 data, except for NO2 since it has a large diurnal variation between ascending/descending intersections. Even taking into account the propagation of the pressure-temperature retrieval errors into the VMR retrieval, the standard deviation of the matching pairs is usually a factor 1–2 larger than the precision. This is thought to be due to effects such as horizontal inhomogeneity of the atmosphere and instability of the retrieval.

  19. The economic case for precision medicine.

    Science.gov (United States)

    Gavan, Sean P; Thompson, Alexander J; Payne, Katherine

    2018-01-01

    Introduction : The advancement of precision medicine into routine clinical practice has been highlighted as an agenda for national and international health care policy. A principle barrier to this advancement is in meeting requirements of the payer or reimbursement agency for health care. This special report aims to explain the economic case for precision medicine, by accounting for the explicit objectives defined by decision-makers responsible for the allocation of limited health care resources. Areas covered : The framework of cost-effectiveness analysis, a method of economic evaluation, is used to describe how precision medicine can, in theory, exploit identifiable patient-level heterogeneity to improve population health outcomes and the relative cost-effectiveness of health care. Four case studies are used to illustrate potential challenges when demonstrating the economic case for a precision medicine in practice. Expert commentary : The economic case for a precision medicine should be considered at an early stage during its research and development phase. Clinical and economic evidence can be generated iteratively and should be in alignment with the objectives and requirements of decision-makers. Programmes of further research, to demonstrate the economic case of a precision medicine, can be prioritized by the extent that they reduce the uncertainty expressed by decision-makers.

  20. MULTI-EPOCH IMAGING POLARIMETRY OF THE SiO MASERS IN THE EXTENDED ATMOSPHERE OF THE MIRA VARIABLE TX CAM

    International Nuclear Information System (INIS)

    Kemball, Athol J.; Diamond, Philip J.; Gonidakis, Ioannis; Mitra, Modhurita; Yim, Kijeong; Pan, K.-C.; Chiang, H.-F.

    2009-01-01

    We present a time series of synoptic images of the linearly polarized v = 1, J = 1-0 SiO maser emission toward the Mira variable, TX Cam. These data comprise 43 individual epochs at an approximate biweekly sampling over an optical pulsation phase range of φ = 0.68 to φ = 1.82. The images have an angular resolution of ∼500 μas and were obtained using the Very Long Baseline Array (VLBA), operating in the 43 GHz band in spectral-line, polarization mode. We have previously published the total intensity time series for this pulsation phase range; this paper serves to present the linearly polarized image sequence and an associated animation representing the evolution of the linear polarization morphology over time. We find a predominantly tangential polarization morphology, a high degree of persistence in linear polarization properties over individual component lifetimes, and stronger linear polarization in the inner projected shell than at larger projected shell radii. We present an initial polarization proper motion analysis examining the possible dynamical influence of magnetic fields in component motions in the extended atmospheres of late-type, evolved stars.

  1. The optical variability of SDSS quasars from multi-epoch spectroscopy. I. Results from 60 quasars with ≥ six-epoch spectra

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Hengxiao; Gu, Minfeng, E-mail: hxguo@shao.ac.cn, E-mail: gumf@shao.ac.cn [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, Shanghai 200030 (China)

    2014-09-01

    In a sample of 60 quasars selected from the Sloan Digital Sky Survey with at least six-epoch spectroscopy, we investigate the variability of emission lines and continuum luminosity at various aspects. A strong anti-correlation between the variability and continuum luminosity at 2500 Å is found for the sample, which is consistent with previous works. In individual sources, we find that half of the sample objects follow the trend of being bluer when brighter, while the remaining half follow the redder-when-brighter (RWB) trend. Although the mechanism for RWB is unclear, the effects of host galaxy contribution due to seeing variations cannot be completely ruled out. As expected from the photoionization model, the positive correlations between the broad emission line and continuum luminosity are found in most individual sources, as well as for the whole sample. We confirm the Baldwin effect in most individual objects and the whole sample, while a negative Baldwin effect is also found in several quasars, which can be at least partly (if not all) due to the host galaxy contamination. We find positive correlations between the broad emission line luminosity and line width in most individual quasars, as well as the whole sample, implying a line base that is more variable than the line core.

  2. Conducting Precision Medicine Research with African Americans.

    Science.gov (United States)

    Halbert, Chanita Hughes; McDonald, Jasmine; Vadaparampil, Susan; Rice, LaShanta; Jefferson, Melanie

    2016-01-01

    Precision medicine is an approach to detecting, treating, and managing disease that is based on individual variation in genetic, environmental, and lifestyle factors. Precision medicine is expected to reduce health disparities, but this will be possible only if studies have adequate representation of racial minorities. It is critical to anticipate the rates at which individuals from diverse populations are likely to participate in precision medicine studies as research initiatives are being developed. We evaluated the likelihood of participating in a clinical study for precision medicine. Observational study conducted between October 2010 and February 2011 in a national sample of African Americans. Intentions to participate in a government sponsored study that involves providing a biospecimen and generates data that could be shared with other researchers to conduct future studies. One third of respondents would participate in a clinical study for precision medicine. Only gender had a significant independent association with participation intentions. Men had a 1.86 (95% CI = 1.11, 3.12, p = 0.02) increased likelihood of participating in a precision medicine study compared to women in the model that included overall barriers and facilitators. In the model with specific participation barriers, distrust was associated with a reduced likelihood of participating in the research described in the vignette (OR = 0.57, 95% CI = 0.34, 0.96, p = 0.04). African Americans may have low enrollment in PMI research. As PMI research is implemented, extensive efforts will be needed to ensure adequate representation. Additional research is needed to identify optimal ways of ethically describing precision medicine studies to ensure sufficient recruitment of racial minorities.

  3. Precision forging technology for aluminum alloy

    Science.gov (United States)

    Deng, Lei; Wang, Xinyun; Jin, Junsong; Xia, Juchen

    2018-03-01

    Aluminum alloy is a preferred metal material for lightweight part manufacturing in aerospace, automobile, and weapon industries due to its good physical properties, such as low density, high specific strength, and good corrosion resistance. However, during forging processes, underfilling, folding, broken streamline, crack, coarse grain, and other macro- or microdefects are easily generated because of the deformation characteristics of aluminum alloys, including narrow forgeable temperature region, fast heat dissipation to dies, strong adhesion, high strain rate sensitivity, and large flow resistance. Thus, it is seriously restricted for the forged part to obtain precision shape and enhanced property. In this paper, progresses in precision forging technologies of aluminum alloy parts were reviewed. Several advanced precision forging technologies have been developed, including closed die forging, isothermal die forging, local loading forging, metal flow forging with relief cavity, auxiliary force or vibration loading, casting-forging hybrid forming, and stamping-forging hybrid forming. High-precision aluminum alloy parts can be realized by controlling the forging processes and parameters or combining precision forging technologies with other forming technologies. The development of these technologies is beneficial to promote the application of aluminum alloys in manufacturing of lightweight parts.

  4. Precision medicine for advanced prostate cancer.

    Science.gov (United States)

    Mullane, Stephanie A; Van Allen, Eliezer M

    2016-05-01

    Precision cancer medicine, the use of genomic profiling of patient tumors at the point-of-care to inform treatment decisions, is rapidly changing treatment strategies across cancer types. Precision medicine for advanced prostate cancer may identify new treatment strategies and change clinical practice. In this review, we discuss the potential and challenges of precision medicine in advanced prostate cancer. Although primary prostate cancers do not harbor highly recurrent targetable genomic alterations, recent reports on the genomics of metastatic castration-resistant prostate cancer has shown multiple targetable alterations in castration-resistant prostate cancer metastatic biopsies. Therapeutic implications include targeting prevalent DNA repair pathway alterations with PARP-1 inhibition in genomically defined subsets of patients, among other genomically stratified targets. In addition, multiple recent efforts have demonstrated the promise of liquid tumor profiling (e.g., profiling circulating tumor cells or cell-free tumor DNA) and highlighted the necessary steps to scale these approaches in prostate cancer. Although still in the initial phase of precision medicine for prostate cancer, there is extraordinary potential for clinical impact. Efforts to overcome current scientific and clinical barriers will enable widespread use of precision medicine approaches for advanced prostate cancer patients.

  5. The Challenges of Precision Medicine in COPD.

    Science.gov (United States)

    Cazzola, Mario; Calzetta, Luigino; Rogliani, Paola; Matera, Maria Gabriella

    2017-08-01

    Pheno-/endotyping chronic obstructive pulmonary disease (COPD) is really important because it provides patients with precise and personalized medicine. The central concept of precision medicine is to take individual variability into account when making management decisions. Precision medicine should ensure that patients get the right treatment at the right dose at the right time, with minimum harmful consequences and maximum efficacy. Ideally, we should search for genetic and molecular biomarker-based profiles. Given the clinical complexity of COPD, it seems likely that a panel of several biomarkers will be required to characterize pathogenetic factors and their course over time. The need for biomarkers to guide the clinical care of individuals with COPD and to enhance the possibilities of success in drug development is clear and urgent, but biomarker development is tremendously challenging and expensive, and translation of research efforts to date has been largely ineffective. Furthermore, the development of personalized treatments will require a much more detailed understanding of the clinical and biological heterogeneity of COPD. Therefore, we are still far from being able to apply precision medicine in COPD and the treatable traits and FEV 1 -free approaches are attempts to precision medicine in COPD that must be considered still quite unsophisticated.

  6. Apparatus for precision micromachining with lasers

    Science.gov (United States)

    Chang, J.J.; Dragon, E.P.; Warner, B.E.

    1998-04-28

    A new material processing apparatus using a short-pulsed, high-repetition-rate visible laser for precision micromachining utilizes a near diffraction limited laser, a high-speed precision two-axis tilt-mirror for steering the laser beam, an optical system for either focusing or imaging the laser beam on the part, and a part holder that may consist of a cover plate and a back plate. The system is generally useful for precision drilling, cutting, milling and polishing of metals and ceramics, and has broad application in manufacturing precision components. Precision machining has been demonstrated through percussion drilling and trepanning using this system. With a 30 W copper vapor laser running at multi-kHz pulse repetition frequency, straight parallel holes with size varying from 500 microns to less than 25 microns and with aspect ratios up to 1:40 have been consistently drilled with good surface finish on a variety of metals. Micromilling and microdrilling on ceramics using a 250 W copper vapor laser have also been demonstrated with good results. Materialographic sections of machined parts show little (submicron scale) recast layer and heat affected zone. 1 fig.

  7. The Future of Precision Medicine in Oncology.

    Science.gov (United States)

    Millner, Lori M; Strotman, Lindsay N

    2016-09-01

    Precision medicine in oncology focuses on identifying which therapies are most effective for each patient based on genetic characterization of the cancer. Traditional chemotherapy is cytotoxic and destroys all cells that are rapidly dividing. The foundation of precision medicine is targeted therapies and selecting patients who will benefit most from these therapies. One of the newest aspects of precision medicine is liquid biopsy. A liquid biopsy includes analysis of circulating tumor cells, cell-free nucleic acid, or exosomes obtained from a peripheral blood draw. These can be studied individually or in combination and collected serially, providing real-time information as a patient's cancer changes. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Toward precision medicine in primary biliary cholangitis.

    Science.gov (United States)

    Carbone, Marco; Ronca, Vincenzo; Bruno, Savino; Invernizzi, Pietro; Mells, George F

    2016-08-01

    Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a 'one size fits all' approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  9. High-Precision Computation and Mathematical Physics

    International Nuclear Information System (INIS)

    Bailey, David H.; Borwein, Jonathan M.

    2008-01-01

    At the present time, IEEE 64-bit floating-point arithmetic is sufficiently accurate for most scientific applications. However, for a rapidly growing body of important scientific computing applications, a higher level of numeric precision is required. Such calculations are facilitated by high-precision software packages that include high-level language translation modules to minimize the conversion effort. This paper presents a survey of recent applications of these techniques and provides some analysis of their numerical requirements. These applications include supernova simulations, climate modeling, planetary orbit calculations, Coulomb n-body atomic systems, scattering amplitudes of quarks, gluons and bosons, nonlinear oscillator theory, Ising theory, quantum field theory and experimental mathematics. We conclude that high-precision arithmetic facilities are now an indispensable component of a modern large-scale scientific computing environment.

  10. Subdomain Precise Integration Method for Periodic Structures

    Directory of Open Access Journals (Sweden)

    F. Wu

    2014-01-01

    Full Text Available A subdomain precise integration method is developed for the dynamical responses of periodic structures comprising many identical structural cells. The proposed method is based on the precise integration method, the subdomain scheme, and the repeatability of the periodic structures. In the proposed method, each structural cell is seen as a super element that is solved using the precise integration method, considering the repeatability of the structural cells. The computational efforts and the memory size of the proposed method are reduced, while high computational accuracy is achieved. Therefore, the proposed method is particularly suitable to solve the dynamical responses of periodic structures. Two numerical examples are presented to demonstrate the accuracy and efficiency of the proposed method through comparison with the Newmark and Runge-Kutta methods.

  11. Microhartree precision in density functional theory calculations

    Science.gov (United States)

    Gulans, Andris; Kozhevnikov, Anton; Draxl, Claudia

    2018-04-01

    To address ultimate precision in density functional theory calculations we employ the full-potential linearized augmented plane-wave + local-orbital (LAPW + lo) method and justify its usage as a benchmark method. LAPW + lo and two completely unrelated numerical approaches, the multiresolution analysis (MRA) and the linear combination of atomic orbitals, yield total energies of atoms with mean deviations of 0.9 and 0.2 μ Ha , respectively. Spectacular agreement with the MRA is reached also for total and atomization energies of the G2-1 set consisting of 55 molecules. With the example of α iron we demonstrate the capability of LAPW + lo to reach μ Ha /atom precision also for periodic systems, which allows also for the distinction between the numerical precision and the accuracy of a given functional.

  12. Nanotechnology: The new perspective in precision agriculture

    Directory of Open Access Journals (Sweden)

    Joginder Singh Duhan

    2017-09-01

    Full Text Available Nanotechnology is an interdisciplinary research field. In recent past efforts have been made to improve agricultural yield through exhaustive research in nanotechnology. The green revolution resulted in blind usage of pesticides and chemical fertilizers which caused loss of soil biodiversity and developed resistance against pathogens and pests as well. Nanoparticle-mediated material delivery to plants and advanced biosensors for precision farming are possible only by nanoparticles or nanochips. Nanoencapsulated conventional fertilizers, pesticides and herbicides helps in slow and sustained release of nutrients and agrochemicals resulting in precise dosage to the plants. Nanotechnology based plant viral disease detection kits are also becoming popular and are useful in speedy and early detection of viral diseases. In this article, the potential uses and benefits of nanotechnology in precision agriculture are discussed. The modern nanotechnology based tools and techniques have the potential to address the various problems of conventional agriculture and can revolutionize this sector.

  13. Pushing the precision frontier in Collider Physics

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    The interplay between precise theory predictions and experimental measurements has written a success story in particle physics. After a brief journey into history we will review recent developments which have led  to "revolutions" with regard to precision calculations and to new insights into the structure of quantum field theory. The second part of the talk will focus on phenomenology, especially on Higgs boson pair production as a window to physics beyond the Standard Model, manifesting itself in a modification of those Higgs couplings which are still to a large extent unconstrained, in particular the Higgs boson self-coupling.

  14. Non-precision approach in manual mode

    Directory of Open Access Journals (Sweden)

    М. В. Коршунов

    2013-07-01

    Full Text Available Considered is the method of non-precision approach of an aircraft in the manual mode with a constant angle of path. Advantage of this method consists in the fact that the construction of approach with a constant angle of path provides the stable path of flight. It is also considered a detailed analysis of the possibility of the approach by the above-mentioned method. Conclusions contain recommendations regarding the use of the described method of non-precision approach during training flights.

  15. A method for consistent precision radiation therapy

    International Nuclear Information System (INIS)

    Leong, J.

    1985-01-01

    Using a meticulous setup procedure in which repeated portal films were taken before each treatment until satisfactory portal verifications were obtained, a high degree of precision in patient positioning was achieved. A fluctuation from treatment to treatment, over 11 treatments, of less than +-0.10 cm (S.D.) for anatomical points inside the treatment field was obtained. This, however, only applies to specific anatomical points selected for this positioning procedure and does not apply to all points within the portal. We have generalized this procedure and have suggested a means by which any target volume can be consistently positioned which may approach this degree of precision. (orig.)

  16. Precision medicine: what's all the fuss about?

    Science.gov (United States)

    Barker, Richard

    2016-01-01

    Precision medicine is now recognized globally as a major new era in medicine. It is being driven by advances in genomics and other 'omics' but also by the desire on the part of both health systems and governments to offer more targeted and cost-effective care. However, it faces a number of challenges, from the economics of developing more expensive companion diagnostics to the need to educate patients and the public on the advantages for them. New models of both R&D and care delivery are needed to capture the scientific, clinical and economic benefits of precision medicine.

  17. High precision detector robot arm system

    Science.gov (United States)

    Shu, Deming; Chu, Yong

    2017-01-31

    A method and high precision robot arm system are provided, for example, for X-ray nanodiffraction with an X-ray nanoprobe. The robot arm system includes duo-vertical-stages and a kinematic linkage system. A two-dimensional (2D) vertical plane ultra-precision robot arm supporting an X-ray detector provides positioning and manipulating of the X-ray detector. A vertical support for the 2D vertical plane robot arm includes spaced apart rails respectively engaging a first bearing structure and a second bearing structure carried by the 2D vertical plane robot arm.

  18. Fundamental limits of scintillation detector timing precision

    International Nuclear Information System (INIS)

    Derenzo, Stephen E; Choong, Woon-Seng; Moses, William W

    2014-01-01

    In this paper we review the primary factors that affect the timing precision of a scintillation detector. Monte Carlo calculations were performed to explore the dependence of the timing precision on the number of photoelectrons, the scintillator decay and rise times, the depth of interaction uncertainty, the time dispersion of the optical photons (modeled as an exponential decay), the photodetector rise time and transit time jitter, the leading-edge trigger level, and electronic noise. The Monte Carlo code was used to estimate the practical limits on the timing precision for an energy deposition of 511 keV in 3 mm × 3 mm × 30 mm Lu 2 SiO 5 :Ce and LaBr 3 :Ce crystals. The calculated timing precisions are consistent with the best experimental literature values. We then calculated the timing precision for 820 cases that sampled scintillator rise times from 0 to 1.0 ns, photon dispersion times from 0 to 0.2 ns, photodetector time jitters from 0 to 0.5 ns fwhm, and A from 10 to 10 000 photoelectrons per ns decay time. Since the timing precision R was found to depend on A −1/2  more than any other factor, we tabulated the parameter B, where R = BA −1/2 . An empirical analytical formula was found that fit the tabulated values of B with an rms deviation of 2.2% of the value of B. The theoretical lower bound of the timing precision was calculated for the example of 0.5 ns rise time, 0.1 ns photon dispersion, and 0.2 ns fwhm photodetector time jitter. The lower bound was at most 15% lower than leading-edge timing discrimination for A from 10 to 10 000 photoelectrons ns −1 . A timing precision of 8 ps fwhm should be possible for an energy deposition of 511 keV using currently available photodetectors if a theoretically possible scintillator were developed that could produce 10 000 photoelectrons ns −1 . (paper)

  19. Automatic titrator for high precision plutonium assay

    International Nuclear Information System (INIS)

    Jackson, D.D.; Hollen, R.M.

    1986-01-01

    Highly precise assay of plutonium metal is required for accountability measurements. We have developed an automatic titrator for this determination which eliminates analyst bias and requires much less analyst time. The analyst is only required to enter sample data and start the titration. The automated instrument titrates the sample, locates the end point, and outputs the results as a paper tape printout. Precision of the titration is less than 0.03% relative standard deviation for a single determination at the 250-mg plutonium level. The titration time is less than 5 min

  20. High-speed precision motion control

    CERN Document Server

    Yamaguchi, Takashi; Pang, Chee Khiang

    2011-01-01

    Written for researchers and postgraduate students in Control Engineering, as well as professionals in the Hard Disk Drive industry, this book discusses high-precision and fast servo controls in Hard Disk Drives (HDDs). The editors present a number of control algorithms that enable fast seeking and high precision positioning, and propose problems from commercial products, making the book valuable to researchers in HDDs. Each chapter is self contained, and progresses from concept to technique, present application examples that can be used within automotive, aerospace, aeronautical, and manufactu

  1. Fundamentals of Pharmacogenetics in Personalized, Precision Medicine.

    Science.gov (United States)

    Valdes, Roland; Yin, DeLu Tyler

    2016-09-01

    This article introduces fundamental principles of pharmacogenetics as applied to personalized and precision medicine. Pharmacogenetics establishes relationships between pharmacology and genetics by connecting phenotypes and genotypes in predicting the response of therapeutics in individual patients. We describe differences between precision and personalized medicine and relate principles of pharmacokinetics and pharmacodynamics to applications in laboratory medicine. We also review basic principles of pharmacogenetics, including its evolution, how it enables the practice of personalized therapeutics, and the role of the clinical laboratory. These fundamentals are a segue for understanding specific clinical applications of pharmacogenetics described in subsequent articles in this issue. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Laser technology for high precision satellite tracking

    Science.gov (United States)

    Plotkin, H. H.

    1974-01-01

    Fixed and mobile laser ranging stations have been developed to track satellites equipped with retro-reflector arrays. These have operated consistently at data rates of once per second with range precision better than 50 cm, using Q-switched ruby lasers with pulse durations of 20 to 40 nanoseconds. Improvements are being incorporated to improve the precision to 10 cm, and to permit ranging to more distant satellites. These include improved reflector array designs, processing and analysis of the received reflection pulses, and use of sub-nanosecond pulse duration lasers.

  3. Precision measurements in nuclear beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Naviliat-Cuncic, Oscar, E-mail: naviliat@nscl.msu.edu [Michigan State University, National Superconducting Cyclotron Laboratory and Department of Physics and Astronomy (United States)

    2013-03-15

    Precision measurements in nuclear beta decay provide sensitive means to determine the fundamental coupling of charged fermions to weak bosons and to test discrete symmetries in the weak interaction. The main motivation of such measurements is to find deviations from Standard Model predictions as possible indications of new physics. I focus here on two topics related to precision measurements in beta decay, namely: (i) the determination of the V{sub ud} element of the Cabibbo-Kobayashi-Maskawa quark mixing matrix from nuclear mirror transitions and (ii) selected measurements of time reversal violating correlations in nuclear and neutron decays. These topics complement those presented in other contributions to this conference.

  4. Precision Medicine In Action | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... page please turn JavaScript on. Feature: NIH Precision Medicine Initiative Precision Medicine In Action Past Issues / Fall 2015 Table of ... Dishman "I am totally motivated to support precision medicine because I am one of the early prototype ...

  5. NCI and the Precision Medicine Initiative®

    Science.gov (United States)

    NCI's activities related to precision medicine focuses on new and expanded precision medicine clinical trials; mechanisms to overcome drug resistance to cancer treatments; and developing a shared digital repository of precision medicine trials data.

  6. Ionospheric Modeling for Precise GNSS Applications

    NARCIS (Netherlands)

    Memarzadeh, Y.

    2009-01-01

    The main objective of this thesis is to develop a procedure for modeling and predicting ionospheric Total Electron Content (TEC) for high precision differential GNSS applications. As the ionosphere is a highly dynamic medium, we believe that to have a reliable procedure it is necessary to transfer

  7. High precision, rapid laser hole drilling

    Science.gov (United States)

    Chang, Jim J.; Friedman, Herbert W.; Comaskey, Brian J.

    2013-04-02

    A laser system produces a first laser beam for rapidly removing the bulk of material in an area to form a ragged hole. The laser system produces a second laser beam for accurately cleaning up the ragged hole so that the final hole has dimensions of high precision.

  8. 40 CFR 75.41 - Precision criteria.

    Science.gov (United States)

    2010-07-01

    ... correlation analysis according to the following procedures. (i) Plot each of the paired emissions readings as... and analysis. To demonstrate precision equal to or better than the continuous emission monitoring system, the owner or operator shall conduct an F-test, a correlation analysis, and a t-test for bias as...

  9. Precise relative cross sections for np scattering

    International Nuclear Information System (INIS)

    Goetz, J.; Brogli-Gysin, C.; Hammans, M.; Haffter, P.; Henneck, R.; Jourdan, J.; Masson, G.; Qin, L.M.; Robinson, S.; Sick, I.; Tuccillo, M.

    1994-01-01

    We present data on the differential cross section for neutron-proton scattering for an incident neutron energy of 67 MeV. These data allow a precise determination of the 1 P 1 phase which, in phase-shift analyses, is strongly correlated with the S-D amplitude which we are measuring via different observables. ((orig.))

  10. Surfaces in Precision Engineering, Microengineering and Nanotechnology

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo; Kunzmann, H.; Peggs, G. N.

    2003-01-01

    with precision engineering, microengineering and nanotechnology are presented, encompassing surfaces in computers, MEMS, biomedical systems, light and X-ray optics, as well as in chemical systems. Surface properties at micro and nanoscale are considered, including geometry as well as physical and chemical...

  11. Precision tests of the Standard Model

    International Nuclear Information System (INIS)

    Ol'shevskij, A.G.

    1996-01-01

    The present status of the precision measurements of electroweak observables is discussed with the special emphasis on the results obtained recently. All together these measurements provide the basis for the stringent test of the Standard Model and determination of the SM parameters. 22 refs., 23 figs., 11 tabs

  12. Lane Determination with GPS Precise Point Positioning

    NARCIS (Netherlands)

    Knoop, V.L.; de Bakker, P.F.; Tiberius, C.C.J.M.; van Arem, B.

    2017-01-01

    Modern intelligent transport solutions can achieve an improvement of traffic flow on motorways. With lane-specific measurements and lane-specific control, more measures are possible. Single frequency precise point positioning (PPP) is a newly developed and affordable technique to achieve an

  13. Bringing Precision Medicine to Community Oncologists.

    Science.gov (United States)

    2017-01-01

    Quest Diagnostics has teamed up with Memorial Sloan Kettering Cancer Center and IBM Watson Health to offer IBM Watson Genomics to its network of community cancer centers and hospitals. This new service aims to advance precision medicine by combining genomic tumor sequencing with the power of cognitive computing. ©2017 American Association for Cancer Research.

  14. High-precision positioning of radar scatterers

    NARCIS (Netherlands)

    Dheenathayalan, P.; Small, D.; Schubert, A.; Hanssen, R.F.

    2016-01-01

    Remote sensing radar satellites cover wide areas and provide spatially dense measurements, with millions of scatterers. Knowledge of the precise position of each radar scatterer is essential to identify the corresponding object and interpret the estimated deformation. The absolute position accuracy

  15. Precision of quantum tomographic detection of radiation

    Energy Technology Data Exchange (ETDEWEB)

    D' Ariano, G.M. (Dipartimento di Fisica ' ' Alessandro Volta' ' , Via A. Bassi 6, I-27100, Pavia (Italy) Istituto Nazionale di Fisica Nucleare, Sezione di Pavia, Via A. Bassi 6, I-27100, Pavia (Italy)); Macchiavello, Chiara (Dipartimento di Fisica ' ' Alessandro Volta' ' , Via A. Bassi 6, I-27100, Pavia (Italy)); Paris, M.G.A. (Dipartimento di Fisica ' ' Alessandro Volta' ' , Via A. Bassi 6, I-27100, Pavia (Italy))

    1994-11-21

    Homodyne tomography provides an experimental technique for reconstructing the density matrix of the radiation field. Here we analyze the tomographic precision in recovering observables like the photon number, the quadrature, and the phase. We show that tomographic reconstruction, despite providing a complete characterization of the state of the field, is generally much less efficient than conventional detection techniques. ((orig.))

  16. Precision of quantum tomographic detection of radiation

    International Nuclear Information System (INIS)

    D'Ariano, G.M.; Macchiavello, Chiara; Paris, M.G.A.

    1994-01-01

    Homodyne tomography provides an experimental technique for reconstructing the density matrix of the radiation field. Here we analyze the tomographic precision in recovering observables like the photon number, the quadrature, and the phase. We show that tomographic reconstruction, despite providing a complete characterization of the state of the field, is generally much less efficient than conventional detection techniques. ((orig.))

  17. Precision about the automatic emotional brain.

    Science.gov (United States)

    Vuilleumier, Patrik

    2015-01-01

    The question of automaticity in emotion processing has been debated under different perspectives in recent years. Satisfying answers to this issue will require a better definition of automaticity in terms of relevant behavioral phenomena, ecological conditions of occurrence, and a more precise mechanistic account of the underlying neural circuits.

  18. Technology on precision measurement of mass

    International Nuclear Information System (INIS)

    2005-10-01

    This book mentions mass and scales about technology for precision measurement, which deal with how to measure mass with scale. So it describes the basic things of mass and scales. It includes translated book of international standard OIML with demand of measurement and technology and form for test report and international original standard OIML with metrological and technical requirements and test report format.

  19. Artificial intelligence, physiological genomics, and precision medicine.

    Science.gov (United States)

    Williams, Anna Marie; Liu, Yong; Regner, Kevin R; Jotterand, Fabrice; Liu, Pengyuan; Liang, Mingyu

    2018-04-01

    Big data are a major driver in the development of precision medicine. Efficient analysis methods are needed to transform big data into clinically-actionable knowledge. To accomplish this, many researchers are turning toward machine learning (ML), an approach of artificial intelligence (AI) that utilizes modern algorithms to give computers the ability to learn. Much of the effort to advance ML for precision medicine has been focused on the development and implementation of algorithms and the generation of ever larger quantities of genomic sequence data and electronic health records. However, relevance and accuracy of the data are as important as quantity of data in the advancement of ML for precision medicine. For common diseases, physiological genomic readouts in disease-applicable tissues may be an effective surrogate to measure the effect of genetic and environmental factors and their interactions that underlie disease development and progression. Disease-applicable tissue may be difficult to obtain, but there are important exceptions such as kidney needle biopsy specimens. As AI continues to advance, new analytical approaches, including those that go beyond data correlation, need to be developed and ethical issues of AI need to be addressed. Physiological genomic readouts in disease-relevant tissues, combined with advanced AI, can be a powerful approach for precision medicine for common diseases.

  20. Big Data's Role in Precision Public Health.

    Science.gov (United States)

    Dolley, Shawn

    2018-01-01

    Precision public health is an emerging practice to more granularly predict and understand public health risks and customize treatments for more specific and homogeneous subpopulations, often using new data, technologies, and methods. Big data is one element that has consistently helped to achieve these goals, through its ability to deliver to practitioners a volume and variety of structured or unstructured data not previously possible. Big data has enabled more widespread and specific research and trials of stratifying and segmenting populations at risk for a variety of health problems. Examples of success using big data are surveyed in surveillance and signal detection, predicting future risk, targeted interventions, and understanding disease. Using novel big data or big data approaches has risks that remain to be resolved. The continued growth in volume and variety of available data, decreased costs of data capture, and emerging computational methods mean big data success will likely be a required pillar of precision public health into the future. This review article aims to identify the precision public health use cases where big data has added value, identify classes of value that big data may bring, and outline the risks inherent in using big data in precision public health efforts.

  1. Explicit Covariance Matrix for Particle Measurement Precision

    CERN Document Server

    Karimäki, Veikko

    1997-01-01

    We derive explicit and precise formulae for 3 by 3 error matrix of the particle transverse momentum, direction and impact parameter. The error matrix elements are expressed as functions of up to fourth order statistical moments of the measured coordinates. The formulae are valid for any curvature and track length in case of negligible multiple scattering.

  2. Precision cryogenic temperature data acquisition system

    International Nuclear Information System (INIS)

    Farah, Y.; Sondericker, J.H.

    1985-01-01

    A Multiplexed Temperature Data Acquisition System with an overall precision of +-25 ppM has been designed using state-of-the-art electronics to accurately read temperature between 2.4 K and 600 K from pre-calibrated transducers such as germanium, silicon diode, thermistor or platinum temperature sensors

  3. A fluence device for precise radiation dosimetry

    International Nuclear Information System (INIS)

    Arnott, R.G.T.; Peak, M.J.

    1979-01-01

    An instrument is described which has been designed to ensure precise positioning of samples and sensing devices in three dimensions at all times during irradiation procedures. The system, which is both robust and sensitive, overcomes difficulties experienced when slight variations in the positioning of a sample under irradiation results in large changes in fluence. (UK)

  4. Fiber Scrambling for High Precision Spectrographs

    Science.gov (United States)

    Kaplan, Zachary; Spronck, J. F. P.; Fischer, D.

    2011-05-01

    The detection of Earth-like exoplanets with the radial velocity method requires extreme Doppler precision and long-term stability in order to measure tiny reflex velocities in the host star. Recent planet searches have led to the detection of so called "super-Earths” (up to a few Earth masses) that induce radial velocity changes of about 1 m/s. However, the detection of true Earth analogs requires a precision of 10 cm/s. One of the largest factors limiting Doppler precision is variation in the Point Spread Function (PSF) from observation to observation due to changes in the illumination of the slit and spectrograph optics. Thus, this stability has become a focus of current instrumentation work. Fiber optics have been used since the 1980's to couple telescopes to high-precision spectrographs, initially for simpler mechanical design and control. However, fiber optics are also naturally efficient scramblers. Scrambling refers to a fiber's ability to produce an output beam independent of input. Our research is focused on characterizing the scrambling properties of several types of fibers, including circular, square and octagonal fibers. By measuring the intensity distribution after the fiber as a function of input beam position, we can simulate guiding errors that occur at an observatory. Through this, we can determine which fibers produce the most uniform outputs for the severest guiding errors, improving the PSF and allowing sub-m/s precision. However, extensive testing of fibers of supposedly identical core diameter, length and shape from the same manufacturer has revealed the "personality” of individual fibers. Personality describes differing intensity patterns for supposedly duplicate fibers illuminated identically. Here, we present our results on scrambling characterization as a function of fiber type, while studying individual fiber personality.

  5. Proposal for a CLEO precision vertex detector

    International Nuclear Information System (INIS)

    1991-01-01

    Fermilab experiment E691 and CERN experiment NA32 have demonstrated the enormous power of precision vertexing for studying heavy quark physics. Nearly all collider experiments now have or are installing precision vertex detectors. This is a proposal for a precision vertex detector for CLEO, which will be the pre-eminent heavy quark experiment for at least the next 5 years. The purpose of a precision vertex detector for CLEO is to enhance the capabilities for isolating B, charm, and tau decays and to make it possible to measure the decay time. The precision vertex detector will also significantly improve strange particle identification and help with the tracking. The installation and use of this detector at CLEO is an important step in developing a vertex detector for an asymmetric B factory and therefore in observing CP violation in B decays. The CLEO environment imposes a number of unique conditions and challenges. The machine will be operating near the γ (4S) in energy. This means that B's are produced with a very small velocity and travel a distance about 1/2 that of the expected vertex position resolution. As a consequence B decay time information will not be useful for most physics. On the other hand, the charm products of B decays have a higher velocity. For the long lived D + in particular, vertex information can be used to isolate the charm particle on an event-by-event basis. This helps significantly in reconstructing B's. The vertex resolution for D's from B's is limited by multiple Coulomb scattering of the necessarily rather low momentum tracks. As a consequence it is essential to minimize the material, as measured in radiation lengths, in the beam pip and the vertex detector itself. It is also essential to build the beam pipe and detector with the smallest possible radius

  6. Spike timing precision of neuronal circuits.

    Science.gov (United States)

    Kilinc, Deniz; Demir, Alper

    2018-04-17

    Spike timing is believed to be a key factor in sensory information encoding and computations performed by the neurons and neuronal circuits. However, the considerable noise and variability, arising from the inherently stochastic mechanisms that exist in the neurons and the synapses, degrade spike timing precision. Computational modeling can help decipher the mechanisms utilized by the neuronal circuits in order to regulate timing precision. In this paper, we utilize semi-analytical techniques, which were adapted from previously developed methods for electronic circuits, for the stochastic characterization of neuronal circuits. These techniques, which are orders of magnitude faster than traditional Monte Carlo type simulations, can be used to directly compute the spike timing jitter variance, power spectral densities, correlation functions, and other stochastic characterizations of neuronal circuit operation. We consider three distinct neuronal circuit motifs: Feedback inhibition, synaptic integration, and synaptic coupling. First, we show that both the spike timing precision and the energy efficiency of a spiking neuron are improved with feedback inhibition. We unveil the underlying mechanism through which this is achieved. Then, we demonstrate that a neuron can improve on the timing precision of its synaptic inputs, coming from multiple sources, via synaptic integration: The phase of the output spikes of the integrator neuron has the same variance as that of the sample average of the phases of its inputs. Finally, we reveal that weak synaptic coupling among neurons, in a fully connected network, enables them to behave like a single neuron with a larger membrane area, resulting in an improvement in the timing precision through cooperation.

  7. Full-wave current conveyor precision rectifier

    Directory of Open Access Journals (Sweden)

    Đukić Slobodan R.

    2008-01-01

    Full Text Available A circuit that provides precision rectification of small signal with low temperature sensitivity for frequencies up to 100 kHz without waveform distortion is presented. It utilizes an improved second type current conveyor based on current-steering output stage and biased silicon diodes. The use of a DC current source to bias the rectifying diodes provides higher temperature stability and lower DC offset level at the output. Proposed design of the precision rectifier ensures good current transfer linearity in the range that satisfy class A of the amplifier and good voltage transfer characteristic for low level signals. Distortion during the zero crossing of the input signal is practically eliminated. Design of the proposed rectifier is realized with standard components.

  8. A precision pulser for main ring extraction

    International Nuclear Information System (INIS)

    Dinkel, J.; Biggs, J.

    1985-01-01

    A pulser has been designed to produce a 14 Hz sinusoid current pulse at a 2 s rate with peak amplitudes from 400 amps to 3750 amps, and a long term stability of + or -400 mA. Short term stability is achieved by the use of a precision voltage regulator for the capacitor bank. This voltage regulator uses gate turnoff thyristors to control the charging current to the 13 mF capacitor bank. Load current is monitored with a precision dc current transductor. The peak value is read into a single chip microcomputer programmed to act as a digital regulator. The microcomputer calculates reference values for the capacitor bank charging supply and the capacitor bank voltage regulator

  9. A precision pulser for main ring extraction

    Energy Technology Data Exchange (ETDEWEB)

    Dinkel, J.; Biggs, J.

    1985-10-01

    A pulser has been designed to produce a 14 Hz sinusoid current pulse at a 2 s rate with peak amplitudes from 400 amps to 3750 amps, and a long term stability of + or -400 mA. Short term stability is achieved by the use of a precision voltage regulator for the capacitor bank. This voltage regulator uses gate turnoff thyristors to control the charging current to the 13 mF capacitor bank. Load current is monitored with a precision dc current transductor. The peak value is read into a single chip microcomputer programmed to act as a digital regulator. The microcomputer calculates reference values for the capacitor bank charging supply and the capacitor bank voltage regulator.

  10. Precision pulser for main ring extraction

    International Nuclear Information System (INIS)

    Dinkel, J.; Biggs, J.

    1985-01-01

    A pulser has been designed to produce a 14 Hz sinusoid current pulse at a 2 s rate with peak amplitudes from 400 amps to 3750 amps, and a long term stability of +/-400 mA. Short term stability is achieved by the use of a precision voltage regulator for the capacitor bank. This voltage regulator uses gate turnoff thyristors to control the charging current to the 13 mF capacitor bank. Load current is monitored with a precision dc current transductor. The peak value is read into a single chip microcomputer programmed to act as a digital regulator. The microcomputer calculates reference values for the capacitor bank charging supply and the capacitor bank voltage regulator

  11. Precision experiments with antihydrogen: an outlook

    International Nuclear Information System (INIS)

    Doser, Michael

    2011-01-01

    After a first generation of experiments has demonstrated the feasibility of forming - in a controlled manner - low-energy antihydrogen atoms via several different techniques, a second generation of experiments is now attempting to trap sufficiently cold atoms, or to form an atomic beam of antihydrogen atoms. The goal of these experiments is to carry out comparative precision spectroscopy between hydrogen and antihydrogen, in view of testing the CPT theorem, either through 1S-2S spectroscopy or via a measurement of the hyperfine splitting of the ground state of antihydrogen. A related class of experiments combines techniques from these experiments with recent developments in the formation of positronium to test the gravitational interaction between matter and antimatter. A significant number of challenges and limitations will still need to be overcome before precision measurements with antihydrogen become feasible, with the next significant milestones being either trapping of antihydrogen or the formation of a beam of antihydrogen.

  12. Mobile Robotic Teams Applied to Precision Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Matthew Oley; Kinoshita, Robert Arthur; Mckay, Mark D; Willis, Walter David; Gunderson, R.W.; Flann, N.S.

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University’s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in realtime. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  13. Mobile Robotic Teams Applied to Precision Agriculture

    Energy Technology Data Exchange (ETDEWEB)

    M.D. McKay; M.O. Anderson; N.S. Flann (Utah State University); R.A. Kinoshita; R.W. Gunderson; W.D. Willis (INEEL)

    1999-04-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) and Utah State University�s Center for Self-Organizing and Intelligent Systems (CSOIS) have developed a team of autonomous robotic vehicles applicable to precision agriculture. A unique technique has been developed to plan, coordinate, and optimize missions in large structured environments for these autonomous vehicles in real-time. Two generic tasks are supported: 1) Driving to a precise location, and 2) Sweeping an area while activating on-board equipment. Sensor data and task achievement data is shared among the vehicles enabling them to cooperatively adapt to changing environmental, vehicle, and task conditions. This paper discusses the development of the autonomous robotic team, details of the mission-planning algorithm, and successful field demonstrations at the INEEL.

  14. Improving the precision of noisy oscillators

    Science.gov (United States)

    Moehlis, Jeff

    2014-04-01

    We consider how the period of an oscillator is affected by white noise, with special attention given to the cases of additive noise and parameter fluctuations. Our treatment is based upon the concepts of isochrons, which extend the notion of the phase of a stable periodic orbit to the basin of attraction of the periodic orbit, and phase response curves, which can be used to understand the geometry of isochrons near the periodic orbit. This includes a derivation of the leading-order effect of noise on the statistics of an oscillator’s period. Several examples are considered in detail, which illustrate the use and validity of the theory, and demonstrate how to improve a noisy oscillator’s precision by appropriately tuning system parameters or operating away from a bifurcation point. It is also shown that appropriately timed impulsive kicks can give further improvements to oscillator precision.

  15. Precision measurements of the CKM angle gamma

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The level of CP-violation permitted within the Standard Model cannot account for the matter dominated universe in which we live. Within the Standard Model the CKM matrix, which describes the quark couplings, is expected to be unitary. By making precise measurements of the CKM matrix parameters new physics models can be constrained, or with sufficient precision the effects of physics beyond the standard model might become apparent. The CKM angle gamma is the least well known angle of the unitarity triangle. It is the only angle easily accessible at tree-level, and furthermore has almost no theoretical uncertainties. Therefore it provides an invaluable Standard Model benchmark against which other new physics sensitive tests of the CP-violation can be made. I will discuss recent measurements of gamma using the the Run 1 LHCb dataset, which improve our knowledge of this key parameter.

  16. Precision measurements with LPCTrap at GANIL

    Energy Technology Data Exchange (ETDEWEB)

    Liénard, E., E-mail: lienard@lpccaen.in2p3.fr; Ban, G. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Couratin, C. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Delahaye, P. [GANIL, CEA/DSM-CNRS/IN2P3 (France); Durand, D.; Fabian, X. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Fabre, B. [CELIA, Université Bordeaux, CNRS, CEA (France); Fléchard, X. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Finlay, P. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Mauger, F. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Méry, A. [CIMAP, CEA/CNRS/ENSICAEN, Université de Caen (France); Naviliat-Cuncic, O. [NSCL and Department of Physics and Astronomy, MSU (United States); Pons, B. [CELIA, Université Bordeaux, CNRS, CEA (France); Porobic, T. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Quéméner, G. [LPC CAEN, ENSICAEN, Université de Caen, CNRS/IN2P3 (France); Severijns, N. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium); Thomas, J. C. [GANIL, CEA/DSM-CNRS/IN2P3 (France); Velten, Ph. [Instituut voor Kern- en Stralingsfysica, KU Leuven (Belgium)

    2015-11-15

    The experimental achievements and the results obtained so far with the LPCTrap device installed at GANIL are presented. The apparatus is dedicated to the study of the weak interaction at low energy by means of precise measurements of the β − ν angular correlation parameter in nuclear β decays. So far, the data collected with three isotopes have enabled to determine, for the first time, the charge state distributions of the recoiling ions, induced by shakeoff process. The analysis is presently refined to deduce the correlation parameters, with the potential of improving both the constraint deduced at low energy on exotic tensor currents ({sup 6}He{sup 1+}) and the precision on the V{sub ud} element of the quark-mixing matrix ({sup 35}Ar{sup 1+} and {sup 19}Ne{sup 1+}) deduced from the mirror transitions dataset.

  17. A primer on precision medicine informatics.

    Science.gov (United States)

    Sboner, Andrea; Elemento, Olivier

    2016-01-01

    In this review, we describe key components of a computational infrastructure for a precision medicine program that is based on clinical-grade genomic sequencing. Specific aspects covered in this review include software components and hardware infrastructure, reporting, integration into Electronic Health Records for routine clinical use and regulatory aspects. We emphasize informatics components related to reproducibility and reliability in genomic testing, regulatory compliance, traceability and documentation of processes, integration into clinical workflows, privacy requirements, prioritization and interpretation of results to report based on clinical needs, rapidly evolving knowledge base of genomic alterations and clinical treatments and return of results in a timely and predictable fashion. We also seek to differentiate between the use of precision medicine in germline and cancer. © The Author 2015. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  18. Precision beam splitters for CO2 lasers

    International Nuclear Information System (INIS)

    Franzen, D.L.

    1975-01-01

    Beam splitters for 10-μm lasers are discussed and then applied to the precision measurement of high average powers. In particular, beam splitter stability has been investigated in various materials over the 20--600-W power range with power densities up to 1 kW/cm 2 . The absolute beam splitter ratios are given along with the achieved measurement precisions. The semiconductors investigated were GaAs, CdTe, and ZnSe in addition to one alkali-halide KC1. Standard deviations for the beam splitter ratios of 1% over the power range were typical. Absolute ratios agree with the predictions from Fresnel's equations to 1% or better. The best measurement was made on ZnSe when a standard deviation of 0.4% was obtained for the measurement of a ratio that agreed with a calculation from Fresnel's equations to better than 0.5%

  19. Cyclotrons as Drivers for Precision Neutrino Measurements

    International Nuclear Information System (INIS)

    Alonso, J.; Barletta, W. A.; Winslow, L. A.; Shaevitz, M. H.; Spitz, J.; Conrad, J. M.; Toups, M.; Adelmann, A.

    2014-01-01

    As we enter the age of precision measurement in neutrino physics, improved flux sources are required. These must have a well defined flavor content with energies in ranges where backgrounds are low and cross-section knowledge is high. Very few sources of neutrinos can meet these requirements. However, pion/muon and isotope decay-at-rest sources qualify. The ideal drivers for decay-at-rest sources are cyclotron accelerators, which are compact and relatively inexpensive. This paper describes a scheme to produce decay-at-rest sources driven by such cyclotrons, developed within the DAEδALUS program. Examples of the value of the high precision beams for pursuing Beyond Standard Model interactions are reviewed. New results on a combined DAEδALUS—Hyper-K search for CP violation that achieve errors on the mixing matrix parameter of 4° to 12° are presented

  20. Seismic Motion Stability, Measurement and Precision Control.

    Science.gov (United States)

    1979-12-01

    azimuth reference used for precision alignment of test fixtures and components is a porro prism mounted within the inner labora- tory. The orientation of...14 6.2 Low Frequency Tilt Loop. .................... 15 6.3 Mechanical Resonances . ..................... 17 6.4 Seismometer Matching...this prism is ascertained, using autocollimating theodolites, either by directly "swinging" Polaris into the laboratory from outside through optical

  1. Hidden SUSY from precision gauge unification

    Energy Technology Data Exchange (ETDEWEB)

    Krippendorf, Sven; Nilles, Hans Peter [Bonn Univ. (Germany). Bethe Center for Theoretical Physics; Bonn Univ. (Germany). Physikalisches Inst.; Ratz, Michael [Technische Univ. Muenchen, Garching (Germany). Physik-Department; Winkler, Martin Wolfgang [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-06-15

    We revisit the implications of naturalness and gauge unification in the MSSM. We find that precision unification of the couplings in connection with a small {mu} parameter requires a highly compressed gaugino pattern as it is realized in mirage mediation. Due to the small mass difference between gluino and LSP, collider limits on the gluino mass are drastically relaxed. Without further assumptions, the relic density of the LSP is very close to the observed dark matter density due to coannihilation effects.

  2. Static quarks with improved statistical precision

    International Nuclear Information System (INIS)

    Della Morte, M.; Duerr, S.; Molke, H.; Heitger, J.

    2003-09-01

    We present a numerical study for different discretisations of the static action, concerning cut-off effects and the growth of statistical errors with Euclidean time. An error reduction by an order of magnitude can be obtained with respect to the Eichten-Hill action, for time separations up to 2 fm, keeping discretization errors small. The best actions lead to a big improvement on the precision of the quark mass M b and F B s in the static approximation. (orig.)

  3. Precision Index in the Multivariate Context

    Czech Academy of Sciences Publication Activity Database

    Šiman, Miroslav

    2014-01-01

    Roč. 43, č. 2 (2014), s. 377-387 ISSN 0361-0926 R&D Projects: GA MŠk(CZ) 1M06047 Institutional support: RVO:67985556 Keywords : data depth * multivariate quantile * process capability index * precision index * regression quantile Subject RIV: BA - General Mathematics Impact factor: 0.274, year: 2014 http://library.utia.cas.cz/separaty/2014/SI/siman-0425059.pdf

  4. Proliferation of Precision Strike: Issues for Congress

    Science.gov (United States)

    2012-05-14

    industrial base. Finally, should Congress legislate requirements for DOD to develop precision strike countermeasures and then provide funding for that...Defense, Part 187 – Environmental Effects Abroad of Major Department of Defense Actions, Section 187.3: Definitions. 32 Bryan Clark and Dan Whiteneck...so many missiles ... referring to reports of Venezuelan arms flowing to Colombian guerrillas.... The Chavez regime also has close ties with

  5. Electroweak Precision Measurements with the ATLAS Detector

    CERN Document Server

    Linck, Rebecca Anne; The ATLAS collaboration

    2018-01-01

    As part of its ongoing exploration into the nature of the particles produced in high energy proton-proton collisions, the ATLAS detector has been used to perform a number of new precision electroweak measurements. In this talk the recent measurements of the W-boson mass, the Drell-Yan triple-differential cross-section and the polarisation of tau leptons in Z/γ* → ττ decays will be discussed.

  6. Electroweak precision data and gravitino dark matter

    Indian Academy of Sciences (India)

    We analyze the precision observables in the context of the GDM, focusing on parameter combina- tions that fulfill 0.094 < ΩCDMh2 < 0.129 [7]. In order to simplify the analysis in a motivated manner, we .... m1/2 discussed above maps into an analogous preference for moderate tan β (see ref. [2]). It can be shown that, at the ...

  7. Precision Jet production for the LHC

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Jet production is one of the basic processes at the LHC with numerous uses for standard model and BSM phenomenology. Understanding this process with suitable precision has been a long-standing goal for the particle physics community. I will report on our recent calculation of the NNLO contribution to jet production using antenna subtraction and discuss what these results might mean for jet phenomenology in the near future.

  8. Precision Landing and Hazard Avoidance Doman

    Science.gov (United States)

    Robertson, Edward A.; Carson, John M., III

    2016-01-01

    The Precision Landing and Hazard Avoidance (PL&HA) domain addresses the development, integration, testing, and spaceflight infusion of sensing, processing, and GN&C functions critical to the success and safety of future human and robotic exploration missions. PL&HA sensors also have applications to other mission events, such as rendezvous and docking. Autonomous PL&HA builds upon the core GN&C capabilities developed to enable soft, controlled landings on the Moon, Mars, and other solar system bodies. Through the addition of a Terrain Relative Navigation (TRN) function, precision landing within tens of meters of a map-based target is possible. The addition of a 3-D terrain mapping lidar sensor improves the probability of a safe landing via autonomous, real-time Hazard Detection and Avoidance (HDA). PL&HA significantly improves the probability of mission success and enhances access to sites of scientific interest located in challenging terrain. PL&HA can also utilize external navigation aids, such as navigation satellites and surface beacons. Advanced Lidar Sensors High precision ranging, velocimetry, and 3-D terrain mapping Terrain Relative Navigation (TRN) TRN compares onboard reconnaissance data with real-time terrain imaging data to update the S/C position estimate Hazard Detection and Avoidance (HDA) Generates a high-resolution, 3-D terrain map in real-time during the approach trajectory to identify safe landing targets Inertial Navigation During Terminal Descent High precision surface relative sensors enable accurate inertial navigation during terminal descent and a tightly controlled touchdown within meters of the selected safe landing target.

  9. Accuracy and precision in activation analysis: counting

    International Nuclear Information System (INIS)

    Becker, D.A.

    1974-01-01

    Accuracy and precision in activation analysis was investigated with regard to counting of induced radioactivity. The various parameters discussed include configuration, positioning, density, homogeneity, intensity, radioisotopic purity, peak integration, and nuclear constants. Experimental results are presented for many of these parameters. The results obtained indicate that counting errors often contribute significantly to the inaccuracy and imprecision of analyses. The magnitude of these errors range from less than 1 percent to 10 percent or more in many cases

  10. Hidden SUSY from precision gauge unification

    International Nuclear Information System (INIS)

    Krippendorf, Sven; Nilles, Hans Peter

    2013-06-01

    We revisit the implications of naturalness and gauge unification in the MSSM. We find that precision unification of the couplings in connection with a small μ parameter requires a highly compressed gaugino pattern as it is realized in mirage mediation. Due to the small mass difference between gluino and LSP, collider limits on the gluino mass are drastically relaxed. Without further assumptions, the relic density of the LSP is very close to the observed dark matter density due to coannihilation effects.

  11. Precision Rescue Behavior in North American Ants

    Directory of Open Access Journals (Sweden)

    Katherine Taylor

    2013-07-01

    Full Text Available Altruistic behavior, in which one individual provides aid to another at some cost to itself, is well documented. However, some species engage in a form of altruism, called rescue, that places the altruist in immediate danger. Here we investigate one such example, namely rescuing victims captured by predators. In a field experiment with two North American ant species, Tetramorium sp. E and Prenolepis imparis, individuals were held in artificial snares simulating capture. T. sp. E, but not P. imparis, exhibited digging, pulling, and snare biting, the latter precisely targeted to the object binding the victim. These results are the first to document precision rescue in a North American ant species; moreover, unlike rescue in other ants, T. sp. E rescues conspecifics from different colonies, mirroring their atypical social behavior, namely the lack of aggression between non-nestmate (heterocolonial conspecifics. In a second, observational study designed to demonstrate rescue from an actual predator, T. sp. E victims were dropped into an antlion's pit and the behavior of a single rescuer was observed. Results showed that T. sp. E not only attempted to release the victim, but also risked attacking the predator, suggesting that precision rescue may play an important role in this species' antipredator behavior.

  12. Automation of Precise Time Reference Stations (PTRS)

    Science.gov (United States)

    Wheeler, P. J.

    1985-04-01

    The U.S. Naval Observatory is presently engaged in a program of automating precise time stations (PTS) and precise time reference stations (PTBS) by using a versatile mini-computer controlled data acquisition system (DAS). The data acquisition system is configured to monitor locally available PTTI signals such as LORAN-C, OMEGA, and/or the Global Positioning System. In addition, the DAS performs local standard intercomparison. Computer telephone communications provide automatic data transfer to the Naval Observatory. Subsequently, after analysis of the data, results and information can be sent back to the precise time reference station to provide automatic control of remote station timing. The DAS configuration is designed around state of the art standard industrial high reliability modules. The system integration and software are standardized but allow considerable flexibility to satisfy special local requirements such as stability measurements, performance evaluation and printing of messages and certificates. The DAS operates completely independently and may be queried or controlled at any time with a computer or terminal device (control is protected for use by authorized personnel only). Such DAS equipped PTS are operational in Hawaii, California, Texas and Florida.

  13. Precision of different quantitative ultrasound densitometers

    International Nuclear Information System (INIS)

    Pocock, N.A.; Harris, N.D.; Griffiths, M.R.

    1998-01-01

    Full text: Quantitative ultrasound (QUS) of the calcaneus, which measures Speed of Sound (SOS) and Broadband ultrasound attenuation (BUA), is predictive of the risk of osteoporotic fracture. However, the utility of QUS for predicting fracture risk or for monitoring treatment efficacy depends on its precision and reliability. Published results and manufacturers data vary significantly due to differences in statistical methodology. We have assessed the precision of the current model of the Lunar Achilles and the McCue Cuba QUS densitometers; the most commonly used QUS machines in Australia. Twenty seven subjects had duplicate QUS measurements performed on the same day on both machines. These data were used to calculate the within pair standard deviation (SD) the co-efficient of variation, CV and the standardised co efficient of variation (sCV) which is corrected for the dynamic range. In addition, the co-efficient of reliability (R) was calculated as an index of reliability which is independent of the population mean value, or the dynamic range of the measurements. R ranges between 0 (for no reliability) to 1(for a perfect reliability). The results indicate that the precision of QUS is dependent on the dynamic range and the instrument. Furthermore, they suggest that while QUS is a useful predictor of fracture risk, at present it has limited clinical value in monitoring short term age-related bone loss of 1-2% per year

  14. Precision medicine driven by cancer systems biology.

    Science.gov (United States)

    Filipp, Fabian V

    2017-03-01

    Molecular insights from genome and systems biology are influencing how cancer is diagnosed and treated. We critically evaluate big data challenges in precision medicine. The melanoma research community has identified distinct subtypes involving chronic sun-induced damage and the mitogen-activated protein kinase driver pathway. In addition, despite low mutation burden, non-genomic mitogen-activated protein kinase melanoma drivers are found in membrane receptors, metabolism, or epigenetic signaling with the ability to bypass central mitogen-activated protein kinase molecules and activating a similar program of mitogenic effectors. Mutation hotspots, structural modeling, UV signature, and genomic as well as non-genomic mechanisms of disease initiation and progression are taken into consideration to identify resistance mutations and novel drug targets. A comprehensive precision medicine profile of a malignant melanoma patient illustrates future rational drug targeting strategies. Network analysis emphasizes an important role of epigenetic and metabolic master regulators in oncogenesis. Co-occurrence of driver mutations in signaling, metabolic, and epigenetic factors highlights how cumulative alterations of our genomes and epigenomes progressively lead to uncontrolled cell proliferation. Precision insights have the ability to identify independent molecular pathways suitable for drug targeting. Synergistic treatment combinations of orthogonal modalities including immunotherapy, mitogen-activated protein kinase inhibitors, epigenetic inhibitors, and metabolic inhibitors have the potential to overcome immune evasion, side effects, and drug resistance.

  15. Precision lens assembly with alignment turning system

    Science.gov (United States)

    Ho, Cheng-Fang; Huang, Chien-Yao; Lin, Yi-Hao; Kuo, Hui-Jean; Kuo, Ching-Hsiang; Hsu, Wei-Yao; Chen, Fong-Zhi

    2017-10-01

    The poker chip assembly with high precision lens barrels is widely applied to ultra-high performance optical system. ITRC applies the poker chip assembly technology to the high numerical aperture objective lenses and lithography projection lenses because of its high efficiency assembly process. In order to achieve high precision lens cell for poker chip assembly, an alignment turning system (ATS) is developed. The ATS includes measurement, alignment and turning modules. The measurement module is equipped with a non-contact displacement sensor (NCDS) and an autocollimator (ACM). The NCDS and ACM are used to measure centration errors of the top and the bottom surface of a lens respectively; then the amount of adjustment of displacement and tilt with respect to the rotational axis of the turning machine for the alignment module can be determined. After measurement, alignment and turning processes on the ATS, the centration error of a lens cell with 200 mm in diameter can be controlled within 10 arcsec. Furthermore, a poker chip assembly lens cell with three sub-cells is demonstrated, each sub-cells are measured and accomplished with alignment and turning processes. The lens assembly test for five times by each three technicians; the average transmission centration error of assembly lens is 12.45 arcsec. The results show that ATS can achieve high assembly efficiency for precision optical systems.

  16. Surface characterization protocol for precision aspheric optics

    Science.gov (United States)

    Sarepaka, RamaGopal V.; Sakthibalan, Siva; Doodala, Somaiah; Panwar, Rakesh S.; Kotaria, Rajendra

    2017-10-01

    In Advanced Optical Instrumentation, Aspherics provide an effective performance alternative. The aspheric fabrication and surface metrology, followed by aspheric design are complementary iterative processes for Precision Aspheric development. As in fabrication, a holistic approach of aspheric surface characterization is adopted to evaluate actual surface error and to aim at the deliverance of aspheric optics with desired surface quality. Precision optical surfaces are characterized by profilometry or by interferometry. Aspheric profiles are characterized by contact profilometers, through linear surface scans to analyze their Form, Figure and Finish errors. One must ensure that, the surface characterization procedure does not add to the resident profile errors (generated during the aspheric surface fabrication). This presentation examines the errors introduced post-surface generation and during profilometry of aspheric profiles. This effort is to identify sources of errors and is to optimize the metrology process. The sources of error during profilometry may be due to: profilometer settings, work-piece placement on the profilometer stage, selection of zenith/nadir points of aspheric profiles, metrology protocols, clear aperture - diameter analysis, computational limitations of the profiler and the software issues etc. At OPTICA, a PGI 1200 FTS contact profilometer (Taylor-Hobson make) is used for this study. Precision Optics of various profiles are studied, with due attention to possible sources of errors during characterization, with multi-directional scan approach for uniformity and repeatability of error estimation. This study provides an insight of aspheric surface characterization and helps in optimal aspheric surface production methodology.

  17. Precise Documentation: The Key to Better Software

    Science.gov (United States)

    Parnas, David Lorge

    The prime cause of the sorry “state of the art” in software development is our failure to produce good design documentation. Poor documentation is the cause of many errors and reduces efficiency in every phase of a software product's development and use. Most software developers believe that “documentation” refers to a collection of wordy, unstructured, introductory descriptions, thousands of pages that nobody wanted to write and nobody trusts. In contrast, Engineers in more traditional disciplines think of precise blueprints, circuit diagrams, and mathematical specifications of component properties. Software developers do not know how to produce precise documents for software. Software developments also think that documentation is something written after the software has been developed. In other fields of Engineering much of the documentation is written before and during the development. It represents forethought not afterthought. Among the benefits of better documentation would be: easier reuse of old designs, better communication about requirements, more useful design reviews, easier integration of separately written modules, more effective code inspection, more effective testing, and more efficient corrections and improvements. This paper explains how to produce and use precise software documentation and illustrate the methods with several examples.

  18. Low Cost Precision Lander for Lunar Exploration

    Science.gov (United States)

    Head, J. N.; Gardner, T. G.; Hoppa, G. V.; Seybold, K. G.

    2004-12-01

    For 60 years the US Defense Department has invested heavily in producing small, low mass, precision guided vehicles. The technologies matured under these programs include terrain-aided navigation, closed loop terminal guidance algorithms, robust autopilots, high thrust-to-weight propulsion, autonomous mission management software, sensors, and data fusion. These technologies will aid NASA in addressing New Millennium Science and Technology goals as well as the requirements flowing from the Vision articulated in January 2004. Establishing and resupplying a long term lunar presence will require automated landing precision not yet demonstrated. Precision landing will increase safety and assure mission success. In the DOD world, such technologies are used routinely and reliably. Hence, it is timely to generate a point design for a precise planetary lander useful for lunar exploration. In this design science instruments amount to 10 kg, 16% of the lander vehicle mass. This compares favorably with 7% for Mars Pathfinder and less than 15% for Surveyor. The mission design flies the lander in an inert configuration to the moon, relying on a cruise stage for navigation and TCMs. The lander activates about a minute before impact. A solid booster reduces the vehicle speed to 300-450 m/s. The lander is now about 2 minutes from touchdown and has 600 to 700 m/s delta-v capability, allowing for about 10 km of vehicle divert during terminal descent. This concept of operations is chosen because it closely mimics missile operational timelines used for decades: the vehicle remains inert in a challenging environment, then must execute its mission flawlessly on a moment's notice. The vehicle design consists of a re-plumbed propulsion system, using propellant tanks and thrusters from exoatmospheric programs. A redesigned truss provides hard points for landing gear, electronics, power supply, and science instruments. A radar altimeter and a Digital Scene Matching Area Correlator (DSMAC

  19. Studies in precise neutron optics at JAERI

    International Nuclear Information System (INIS)

    Tomimitsu, Hiroshi

    1994-01-01

    Studies in the field of so-called 'Precise Neutron Optics' at JAERI were reported, since the beginning of 1970. It started with the photographic detection of the 'Pendellusung Fringes' in a wedge-shaped Si crystal, promoted by Prof.K.Kohra. Neutron diffraction topography was also tried and used for the 'direct' observation of the substructure in a Cu-5%Ge single crystal, carried out by the present author. So-called 'VSANS' (Very Small Angle Neutron Scattering) was also tried, with the angular resolution better than 0.1 sec. of arc, for the structural observation of several kinds of 'amorphous' materials, such as neutron-irradiated silica glasses, Pb-containing glasses and several ribbon-shaped amorphous alloys, carried out by Dr.K.Doi. Recently with the co-operation with Prof.S.Kikuta's group, some interferometric experiments were tried, such as the detection of the double-refraction phenomenon of the neutron in the magnetic materials, carried out by Dr.S.Nakatani. The apparatus for precise neutron optics and topography (PNO) was constructed at the JRR-3M in JAERI in 1992, which was just properly made for the studies in the present thema. With the PNO, the characterization of Ni-Ti multilayer mirror for the interferometer with the cold/ ultra-cold neutrons was carried out, the results being reported in the other article of this symposium by Dr.H.Funahashi. Through the test use of the PNO with the neutron interferometry, carried out by Dr.Y.Hasegawa, it was revealed that the PNO is the best facility in the world for the neutron interferometry; with the datas of the count ratio upto 20 cps and the contrast more than 40%. Dr.K.Aizawa is now refining the VSANS-technique on the PNO, for the precise observation of the precipitation behaviour of high density small particles such as metatic alloy-system. (author)

  20. SPOTTED STAR LIGHT CURVES WITH ENHANCED PRECISION

    International Nuclear Information System (INIS)

    Wilson, R. E.

    2012-01-01

    The nearly continuous timewise coverage of recent photometric surveys is free of the large gaps that compromise attempts to follow starspot growth and decay as well as motions, thereby giving incentive to improve computational precision for modeled spots. Due to the wide variety of star systems in the surveys, such improvement should apply to light/velocity curve models that accurately include all the main phenomena of close binaries and rotating single stars. The vector fractional area (VFA) algorithm that is introduced here represents surface elements by small sets of position vectors so as to allow accurate computation of circle-triangle overlap by spherical geometry. When computed by VFA, spots introduce essentially no noticeable scatter in light curves at the level of one part in 10,000. VFA has been put into the Wilson-Devinney light/velocity curve program and all logic and mathematics are given so as to facilitate entry into other such programs. Advantages of precise spot computation include improved statistics of spot motions and aging, reduced computation time (intrinsic precision relaxes needs for grid fineness), noise-free illustration of spot effects in figures, and help in guarding against false positives in exoplanet searches, where spots could approximately mimic transiting planets in unusual circumstances. A simple spot growth and decay template quantifies time profiles, and specifics of its utilization in differential corrections solutions are given. Computational strategies are discussed, the overall process is tested in simulations via solutions of synthetic light curve data, and essential simulation results are described. An efficient time smearing facility by Gaussian quadrature can deal with Kepler mission data that are in 30 minute time bins.

  1. Rapid whole genome sequencing and precision neonatology.

    Science.gov (United States)

    Petrikin, Joshua E; Willig, Laurel K; Smith, Laurie D; Kingsmore, Stephen F

    2015-12-01

    Traditionally, genetic testing has been too slow or perceived to be impractical to initial management of the critically ill neonate. Technological advances have led to the ability to sequence and interpret the entire genome of a neonate in as little as 26 h. As the cost and speed of testing decreases, the utility of whole genome sequencing (WGS) of neonates for acute and latent genetic illness increases. Analyzing the entire genome allows for concomitant evaluation of the currently identified 5588 single gene diseases. When applied to a select population of ill infants in a level IV neonatal intensive care unit, WGS yielded a diagnosis of a causative genetic disease in 57% of patients. These diagnoses may lead to clinical management changes ranging from transition to palliative care for uniformly lethal conditions for alteration or initiation of medical or surgical therapy to improve outcomes in others. Thus, institution of 2-day WGS at time of acute presentation opens the possibility of early implementation of precision medicine. This implementation may create opportunities for early interventional, frequently novel or off-label therapies that may alter disease trajectory in infants with what would otherwise be fatal disease. Widespread deployment of rapid WGS and precision medicine will raise ethical issues pertaining to interpretation of variants of unknown significance, discovery of incidental findings related to adult onset conditions and carrier status, and implementation of medical therapies for which little is known in terms of risks and benefits. Despite these challenges, precision neonatology has significant potential both to decrease infant mortality related to genetic diseases with onset in newborns and to facilitate parental decision making regarding transition to palliative care. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Precision of working memory for speech sounds.

    Science.gov (United States)

    Joseph, Sabine; Iverson, Paul; Manohar, Sanjay; Fox, Zoe; Scott, Sophie K; Husain, Masud

    2015-01-01

    Memory for speech sounds is a key component of models of verbal working memory (WM). But how good is verbal WM? Most investigations assess this using binary report measures to derive a fixed number of items that can be stored. However, recent findings in visual WM have challenged such "quantized" views by employing measures of recall precision with an analogue response scale. WM for speech sounds might rely on both continuous and categorical storage mechanisms. Using a novel speech matching paradigm, we measured WM recall precision for phonemes. Vowel qualities were sampled from a formant space continuum. A probe vowel had to be adjusted to match the vowel quality of a target on a continuous, analogue response scale. Crucially, this provided an index of the variability of a memory representation around its true value and thus allowed us to estimate how memories were distorted from the original sounds. Memory load affected the quality of speech sound recall in two ways. First, there was a gradual decline in recall precision with increasing number of items, consistent with the view that WM representations of speech sounds become noisier with an increase in the number of items held in memory, just as for vision. Based on multidimensional scaling (MDS), the level of noise appeared to be reflected in distortions of the formant space. Second, as memory load increased, there was evidence of greater clustering of participants' responses around particular vowels. A mixture model captured both continuous and categorical responses, demonstrating a shift from continuous to categorical memory with increasing WM load. This suggests that direct acoustic storage can be used for single items, but when more items must be stored, categorical representations must be used.

  3. Precision and reproducibility in AMS radiocarbon measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkis, M A; Fink, D; Hua, Q; Jacobsen, G E; Lawson, E M; Smith, A M; Tuniz, C [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1997-12-31

    Accelerator Mass Spectrometry (AMS) is a technique by which rare radioisotopes such as {sup 14}C can be measured at environmental levels with high efficiency. Instead of detecting radioactivity, which is very weak for long-lived environmental radioisotopes, atoms are counted directly. The sample is placed in an ion source, from which a negative ion beam of the atoms of interest is extracted, mass analysed, and injected into a tandem accelerator. After stripping to positive charge states in the accelerator HV terminal, the ions are further accelerated, analysed with magnetic and electrostatic devices and counted in a detector. An isotopic ratio is derived from the number of radioisotope atoms counted in a given time and the beam current of a stable isotope of the same element, measured after the accelerator. For radiocarbon, {sup 14}C/{sup 13}C ratios are usually measured, and the ratio of an unknown sample is compared to that of a standard. The achievable precision for such ratio measurements is limited primarily by {sup 14}C counting statistics and also by a variety of factors related to accelerator and ion source stability. At the ANTARES AMS facility at Lucas Heights Research Laboratories we are currently able to measure {sup 14}C with 0.5% precision. In the two years since becoming operational, more than 1000 {sup 14}C samples have been measured. Recent improvements in precision for {sup 14}C have been achieved with the commissioning of a 59 sample ion source. The measurement system, from sample changing to data acquisition, is under common computer control. These developments have allowed a new regime of automated multi-sample processing which has impacted both on the system throughput and the measurement precision. We have developed data evaluation methods at ANTARES which cross-check the self-consistency of the statistical analysis of our data. Rigorous data evaluation is invaluable in assessing the true reproducibility of the measurement system and aids in

  4. Precision and reproducibility in AMS radiocarbon measurements.

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkis, M.A.; Fink, D.; Hua, Q.; Jacobsen, G.E.; Lawson, E. M.; Smith, A.M.; Tuniz, C. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia)

    1996-12-31

    Accelerator Mass Spectrometry (AMS) is a technique by which rare radioisotopes such as {sup 14}C can be measured at environmental levels with high efficiency. Instead of detecting radioactivity, which is very weak for long-lived environmental radioisotopes, atoms are counted directly. The sample is placed in an ion source, from which a negative ion beam of the atoms of interest is extracted, mass analysed, and injected into a tandem accelerator. After stripping to positive charge states in the accelerator HV terminal, the ions are further accelerated, analysed with magnetic and electrostatic devices and counted in a detector. An isotopic ratio is derived from the number of radioisotope atoms counted in a given time and the beam current of a stable isotope of the same element, measured after the accelerator. For radiocarbon, {sup 14}C/{sup 13}C ratios are usually measured, and the ratio of an unknown sample is compared to that of a standard. The achievable precision for such ratio measurements is limited primarily by {sup 14}C counting statistics and also by a variety of factors related to accelerator and ion source stability. At the ANTARES AMS facility at Lucas Heights Research Laboratories we are currently able to measure {sup 14}C with 0.5% precision. In the two years since becoming operational, more than 1000 {sup 14}C samples have been measured. Recent improvements in precision for {sup 14}C have been achieved with the commissioning of a 59 sample ion source. The measurement system, from sample changing to data acquisition, is under common computer control. These developments have allowed a new regime of automated multi-sample processing which has impacted both on the system throughput and the measurement precision. We have developed data evaluation methods at ANTARES which cross-check the self-consistency of the statistical analysis of our data. Rigorous data evaluation is invaluable in assessing the true reproducibility of the measurement system and aids in

  5. Millisecond Pulsar Timing Precision with NICER

    Science.gov (United States)

    Deneva, Julia; Ray, Paul S.; Ransom, Scott; Wood, Kent S.; Kerr, Matthew T.; Lommen, Andrea; Arzoumanian, Zaven; Black, Kevin; Gendreau, Keith C.; Lewandowska, Natalia; Markwardt, Craig B.; Price, Samuel; Winternitz, Luke

    2018-01-01

    The Neutron Star Interior Composition Explorer (NICER) is an array of 56 X-ray detectors mounted on the outside of the International Space Station. It allows high-precision timing of millisecond pulsars (MSPs) without the pulse broadening effects due to dispersion and scattering by the interstellar medium that plague radio timing. We present initial timing results from four months of NICER data on the MSPs B1937+21, B1821-24, and J0218+4232, and compare them to simulations and theoretical models for X-ray times-of-arrival, and radio observations.

  6. Lasers the power and precision of light

    CERN Document Server

    Diels, Jean-Claude

    2011-01-01

    ""Lasers"" are active ingredients of our modern life, but they are inconspicuous as they often go unnoticed. This intuitive introductory guide will tell you all you want to know about laser technologies in very diverse fields from nuclear and particle physics to medicine, astronomy and ultra-precise metrology. The book is coherently focused on fundamentals, and is aimed to stimulate intuition about present and future applications, while unveiling the halo of myths around lasers. Written by reputable laser experts who think that science should be entertaining, this useful reference relies on si

  7. Autocalibration of high precision drift tubes

    International Nuclear Information System (INIS)

    Bacci, C.; Bini, C.; Ciapetti, G.; De Zorzi, G.; Gauzzi, P.; Lacava, F.; Nisati, A.; Pontecorvo, L.; Rosati, S.; Veneziano, S.; Cambiaghi, M.; Casellotti, G.; Conta, C.; Fraternali, M.; Lanza, A.; Livan, M.; Polesello, G.; Rimoldi, A.; Vercesi, V.

    1997-01-01

    We present the results on MDT (monitored drift tubes) autocalibration studies obtained from the analysis of the data collected in Summer 1995 on the H8B Muon Test Beam. In particular we studied the possibility of autocalibration of the MDT using four or three layers of tubes, and we compared the calibration obtained using a precise external tracker with the output of the autocalibration procedure. Results show the feasibility of autocalibration with four and three tubes and the good accuracy of the autocalibration procedure. (orig.)

  8. Precision Mass Measurement of Argon Isotopes

    CERN Multimedia

    Lunney, D

    2002-01-01

    % IS388\\\\ \\\\ A precision mass measurement of the neutron-deficient isotopes $^{32,33,34}$Ar is proposed. Mass values of these isotopes are of importance for: a) a stringent test of the Isobaric-Multiplet- Mass-Equation, b) a verification of the correctness of calculated charge-dependent corrections as used in super-allowed $\\beta$- decay studies aiming at a test of the CVC hypothesis, and c) the determination of the kinematics in electron-neutrino correlation experiments searching for scalar currents in weak interaction. The measurements will be carried out with the ISOLTRAP Penning trap mass spectrometer.

  9. The precision of locomotor odometry in humans.

    Science.gov (United States)

    Durgin, Frank H; Akagi, Mikio; Gallistel, Charles R; Haiken, Woody

    2009-03-01

    Two experiments measured the human ability to reproduce locomotor distances of 4.6-100 m without visual feedback and compared distance production with time production. Subjects were not permitted to count steps. It was found that the precision of human odometry follows Weber's law that variability is proportional to distance. The coefficients of variation for distance production were much lower than those measured for time production for similar durations. Gait parameters recorded during the task (average step length and step frequency) were found to be even less variable suggesting that step integration could be the basis for non-visual human odometry.

  10. Precision medicine in patients with allergic diseases

    DEFF Research Database (Denmark)

    Muraro, Antonella; Lemanske, Robert F; Hellings, Peter W

    2016-01-01

    In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy...... of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction...

  11. A precise technique for manufacturing correction coil

    International Nuclear Information System (INIS)

    Schieber, L.

    1992-01-01

    An automated method of manufacturing correction coils has been developed which provides a precise embodiment of the coil design. Numerically controlled machines have been developed to accurately position coil windings on the beam tube. Two types of machines have been built. One machine bonds the wire to a substrate which is wrapped around the beam tube after it is completed while the second machine bonds the wire directly to the beam tube. Both machines use the Multiwire reg-sign technique of bonding the wire to the substrate utilizing an ultrasonic stylus. These machines are being used to manufacture coils for both the SSC and RHIC

  12. Recent high precision surveys at PEP

    International Nuclear Information System (INIS)

    Sah, R.C.

    1980-12-01

    The task of surveying and aligning the components of PEP has provided an opportunity to develop new instruments and techniques for the purpose of high precision surveys. The new instruments are quick and easy to use, and they automatically encode survey data and read them into the memory of an on-line computer. When measurements of several beam elements have been taken, the on-line computer analyzes the measured data, compares them with desired parameters, and calculates the required adjustments to beam element support stands

  13. Environmental Testing for Precision Parts and Instruments

    International Nuclear Information System (INIS)

    Choi, Man Yong; Park, Jeong Hak; Yun, Kyu Tek

    2001-01-01

    Precision parts and instruments are tested to evaluate performance in development-process and product-step to prement a potential defect due to a failure design. In this paper, Environmental test technology, which is the basis of reliability analysis, is introduced with examples of test criterion, test method for products, encoder and traffic signal controller, and measuring instruments. Recently, as the importance of the environmental test technology is recognised. It is proposed that training of test technician and technology of jig design and failure analysis are very essential

  14. ASTROMETRY WITH THE HUBBLE SPACE TELESCOPE: TRIGONOMETRIC PARALLAXES OF PLANETARY NEBULA NUCLEI NGC 6853, NGC 7293, ABELL 31, AND DeHt 5

    International Nuclear Information System (INIS)

    Benedict, G. Fritz; McArthur, Barbara E.; Napiwotzki, Ralf; Harrison, Thomas E.; Harris, Hugh C.; Nelan, Edmund; Bond, Howard E.; Patterson, Richard J.; Ciardullo, Robin

    2009-01-01

    We present absolute parallaxes and relative proper motions for the central stars of the planetary nebulae NGC 6853 (The Dumbbell), NGC 7293 (The Helix), Abell 31, and DeHt 5. This paper details our reduction and analysis using DeHt 5 as an example. We obtain these planetary nebula nuclei (PNNi) parallaxes with astrometric data from Fine Guidance Sensors FGS 1r and FGS 3, white-light interferometers on the Hubble Space Telescope. Proper motions, spectral classifications and VJHKT 2 M and DDO51 photometry of the stars comprising the astrometric reference frames provide spectrophotometric estimates of reference star absolute parallaxes. Introducing these into our model as observations with error, we determine absolute parallaxes for each PNN. Weighted averaging with previous independent parallax measurements yields an average parallax precision, σ π /π = 5%. Derived distances are: d NGC6853 = 405 +28 -25 pc, d NGC7293 = 216 +14 -12 pc, d Abell31 = 621 +91 -70 pc, and d DeHt5 = 345 +19 -17 pc. These PNNi distances are all smaller than previously derived from spectroscopic analyses of the central stars. To obtain absolute magnitudes from these distances requires estimates of interstellar extinction. We average extinction measurements culled from the literature, from reddening based on PNNi intrinsic colors derived from model SEDs, and an assumption that each PNN experiences the same rate of extinction as a function of distance as do the reference stars nearest (in angular separation) to each central star. We also apply Lutz-Kelker bias corrections. The absolute magnitudes and effective temperatures permit estimates of PNNi radii through both the Stefan-Boltzmann relation and Eddington fluxes. Comparing absolute magnitudes with post-AGB models provides mass estimates. Masses cluster around 0.57 M odot , close to the peak of the white dwarf mass distribution. Adding a few more PNNi with well-determined distances and masses, we compare all the PNNi with cooler white

  15. Precise positioning of patients for radiation therapy

    International Nuclear Information System (INIS)

    Verhey, L.J.; Goitein, M.; McNulty, P.; Munzenrider, J.E.; Suit, H.D.

    1982-01-01

    A number of immobilization schemes which permit precise daily positioning of patients for radiation therapy are discussed. Pretreatment and post-treatment radiographs have been taken with the patient in the treatment position and analyzed to determine the amount of intratreatment movement. Studies of patients in the supine, seated and decubitus positions indicate mean movements of less than 1 mm with a standard deviation of less than 1 mm. Patients immobilized in the seated position with a bite block and a mask have a mean movement of about 0.5 mm +/- 0.3 mm (s.d.), and patients immobilized in the supine position with their necks hyperextended for submental therapy evidence a mean movement of about 1.4 mm +/- 0.9 mm (s.d.). With the exception of those used for the decubitus position, the immobilization devices are simply fabricated out of thermoplastic casting materials readily available from orthopedic supply houses. A study of day-to-day reproducibility of patient position using laser alignment and pretreatment radiographs for final verification of position indicates that the initial laser alignment can be used to position a patient within 2.2 mm +/- 1.4 mm (s.d.) of the intended position. These results indicate that rigid immobilization devices can improve the precision of radiotherapy, which would be advantageous with respect to both tumor and normal tissue coverage in certain situations

  16. Glass ceramic ZERODUR enabling nanometer precision

    Science.gov (United States)

    Jedamzik, Ralf; Kunisch, Clemens; Nieder, Johannes; Westerhoff, Thomas

    2014-03-01

    The IC Lithography roadmap foresees manufacturing of devices with critical dimension of digit nanometer asking for nanometer positioning accuracy requiring sub nanometer position measurement accuracy. The glass ceramic ZERODUR® is a well-established material in critical components of microlithography wafer stepper and offered with an extremely low coefficient of thermal expansion (CTE), the tightest tolerance available on market. SCHOTT is continuously improving manufacturing processes and it's method to measure and characterize the CTE behavior of ZERODUR® to full fill the ever tighter CTE specification for wafer stepper components. In this paper we present the ZERODUR® Lithography Roadmap on the CTE metrology and tolerance. Additionally, simulation calculations based on a physical model are presented predicting the long term CTE behavior of ZERODUR® components to optimize dimensional stability of precision positioning devices. CTE data of several low thermal expansion materials are compared regarding their temperature dependence between - 50°C and + 100°C. ZERODUR® TAILORED 22°C is full filling the tight CTE tolerance of +/- 10 ppb / K within the broadest temperature interval compared to all other materials of this investigation. The data presented in this paper explicitly demonstrates the capability of ZERODUR® to enable the nanometer precision required for future generation of lithography equipment and processes.

  17. High precision innovative micropump for artificial pancreas

    Science.gov (United States)

    Chappel, E.; Mefti, S.; Lettieri, G.-L.; Proennecke, S.; Conan, C.

    2014-03-01

    The concept of artificial pancreas, which comprises an insulin pump, a continuous glucose meter and a control algorithm, is a major step forward in managing patient with type 1 diabetes mellitus. The stability of the control algorithm is based on short-term precision micropump to deliver rapid-acting insulin and to specific integrated sensors able to monitor any failure leading to a loss of accuracy. Debiotech's MEMS micropump, based on the membrane pump principle, is made of a stack of 3 silicon wafers. The pumping chamber comprises a pillar check-valve at the inlet, a pumping membrane which is actuated against stop limiters by a piezo cantilever, an anti-free-flow outlet valve and a pressure sensor. The micropump inlet is tightly connected to the insulin reservoir while the outlet is in direct communication with the patient skin via a cannula. To meet the requirement of a pump dedicated to closed-loop application for diabetes care, in addition to the well-controlled displacement of the pumping membrane, the high precision of the micropump is based on specific actuation profiles that balance effect of pump elasticity in low-consumption push-pull mode.

  18. Precise Point Positioning with Partial Ambiguity Fixing.

    Science.gov (United States)

    Li, Pan; Zhang, Xiaohong

    2015-06-10

    Reliable and rapid ambiguity resolution (AR) is the key to fast precise point positioning (PPP). We propose a modified partial ambiguity resolution (PAR) method, in which an elevation and standard deviation criterion are first used to remove the low-precision ambiguity estimates for AR. Subsequently the success rate and ratio-test are simultaneously used in an iterative process to increase the possibility of finding a subset of decorrelated ambiguities which can be fixed with high confidence. One can apply the proposed PAR method to try to achieve an ambiguity-fixed solution when full ambiguity resolution (FAR) fails. We validate this method using data from 450 stations during DOY 021 to 027, 2012. Results demonstrate the proposed PAR method can significantly shorten the time to first fix (TTFF) and increase the fixing rate. Compared with FAR, the average TTFF for PAR is reduced by 14.9% for static PPP and 15.1% for kinematic PPP. Besides, using the PAR method, the average fixing rate can be increased from 83.5% to 98.2% for static PPP, from 80.1% to 95.2% for kinematic PPP respectively. Kinematic PPP accuracy with PAR can also be significantly improved, compared to that with FAR, due to a higher fixing rate.

  19. Ultra-wideband ranging precision and accuracy

    International Nuclear Information System (INIS)

    MacGougan, Glenn; O'Keefe, Kyle; Klukas, Richard

    2009-01-01

    This paper provides an overview of ultra-wideband (UWB) in the context of ranging applications and assesses the precision and accuracy of UWB ranging from both a theoretical perspective and a practical perspective using real data. The paper begins with a brief history of UWB technology and the most current definition of what constitutes an UWB signal. The potential precision of UWB ranging is assessed using Cramer–Rao lower bound analysis. UWB ranging methods are described and potential error sources are discussed. Two types of commercially available UWB ranging radios are introduced which are used in testing. Actual ranging accuracy is assessed from line-of-sight testing under benign signal conditions by comparison to high-accuracy electronic distance measurements and to ranges derived from GPS real-time kinematic positioning. Range measurements obtained in outdoor testing with line-of-sight obstructions and strong reflection sources are compared to ranges derived from classically surveyed positions. The paper concludes with a discussion of the potential applications for UWB ranging

  20. Software for precise tracking of cell proliferation

    International Nuclear Information System (INIS)

    Kurokawa, Hiroshi; Noda, Hisayori; Sugiyama, Mayu; Sakaue-Sawano, Asako; Fukami, Kiyoko; Miyawaki, Atsushi

    2012-01-01

    Highlights: ► We developed software for analyzing cultured cells that divide as well as migrate. ► The active contour model (Snakes) was used as the core algorithm. ► The time backward analysis was also used for efficient detection of cell division. ► With user-interactive correction functions, the software enables precise tracking. ► The software was successfully applied to cells with fluorescently-labeled nuclei. -- Abstract: We have developed a multi-target cell tracking program TADOR, which we applied to a series of fluorescence images. TADOR is based on an active contour model that is modified in order to be free of the problem of locally optimal solutions, and thus is resistant to signal fluctuation and morphological changes. Due to adoption of backward tracing and addition of user-interactive correction functions, TADOR is used in an off-line and semi-automated mode, but enables precise tracking of cell division. By applying TADOR to the analysis of cultured cells whose nuclei had been fluorescently labeled, we tracked cell division and cell-cycle progression on coverslips over an extended period of time.

  1. Usefulness of Models in Precision Nutrient Management

    DEFF Research Database (Denmark)

    Plauborg, Finn; Manevski, Kiril; Zhenjiang, Zhou

    Modern agriculture increasingly applies new methods and technologies to increase production and nutrient use efficiencies and at the same time reduce leaching of nutrients and greenhouse gas emissions. GPS based ECa-measurement equipment, ER or EM instrumentations, are used to spatially character......Modern agriculture increasingly applies new methods and technologies to increase production and nutrient use efficiencies and at the same time reduce leaching of nutrients and greenhouse gas emissions. GPS based ECa-measurement equipment, ER or EM instrumentations, are used to spatially...... and mineral composition. Mapping of crop status and the spatial-temporal variability within fields with red-infrared reflection are used to support decision on split fertilisation and more precise dosing. The interpretation and use of these various data in precise nutrient management is not straightforward...... of mineralisation. However, whether the crop would benefit from this depended to a large extent on soil hydraulic conductivity within the range of natural variation when testing the model. In addition the initialisation of the distribution of soil total carbon and nitrogen into conceptual model compartments...

  2. Golden Jubilee photos: Precision is their motto

    CERN Multimedia

    2004-01-01

    At the beginning of the 1980s, CERN embarked on the enormous Large Electron-Positron Collider construction project. The excavation of the 27-kilometre LEP tunnel was a huge technical challenge. The tunnel-boring machines excavated the tunnel in 3.3 km octants and had to be operated with extraordinary precision to ensure that they reached their destination - the bottom of the next vertical shaft - precisely on target. The tunnel was excavated before high-performance instruments were developed for the construction of the Channel Tunnel. As no firms were willing to perform the surveying work, CERN's own surveyors, with experience from the SPS behind them, took up the challenge. At the surface, the surveyors established the world's most accurate geodetic network, performing measurements to an accuracy of 10-7, or 1mm per 10 km, using the Terrameter (see photo). The excavation of the tunnel was completed in 1988 and the finished tunnel's trajectory was found to diverge from the theoretical value specified by the...

  3. Structurally uniform and atomically precise carbon nanostructures

    Science.gov (United States)

    Segawa, Yasutomo; Ito, Hideto; Itami, Kenichiro

    2016-01-01

    Nanometre-sized carbon materials consisting of benzene units oriented in unique geometric patterns, hereafter named nanocarbons, conduct electricity, absorb and emit light, and exhibit interesting magnetic properties. Spherical fullerene C60, cylindrical carbon nanotubes and sheet-like graphene are representative forms of nanocarbons, and theoretical simulations have predicted several exotic 3D nanocarbon structures. At present, synthetic routes to nanocarbons mainly lead to mixtures of molecules with a range of different structures and properties, which cannot be easily separated or refined into pure forms. Some researchers believe that it is impossible to synthesize these materials in a precise manner. Obtaining ‘pure’ nanocarbons is a great challenge in the field of nanocarbon science, and the construction of structurally uniform nanocarbons, ideally as single molecules, is crucial for the development of functional materials in nanotechnology, electronics, optics and biomedical applications. This Review highlights the organic chemistry approach — more specifically, bottom-up construction with atomic precision — that is currently the most promising strategy towards this end.

  4. Soviet precision timekeeping research and technology

    Energy Technology Data Exchange (ETDEWEB)

    Vessot, R.F.C.; Allan, D.W.; Crampton, S.J.B.; Cutler, L.S.; Kern, R.H.; McCoubrey, A.O.; White, J.D.

    1991-08-01

    This report is the result of a study of Soviet progress in precision timekeeping research and timekeeping capability during the last two decades. The study was conducted by a panel of seven US scientists who have expertise in timekeeping, frequency control, time dissemination, and the direct applications of these disciplines to scientific investigation. The following topics are addressed in this report: generation of time by atomic clocks at the present level of their technology, new and emerging technologies related to atomic clocks, time and frequency transfer technology, statistical processes involving metrological applications of time and frequency, applications of precise time and frequency to scientific investigations, supporting timekeeping technology, and a comparison of Soviet research efforts with those of the United States and the West. The number of Soviet professionals working in this field is roughly 10 times that in the United States. The Soviet Union has facilities for large-scale production of frequency standards and has concentrated its efforts on developing and producing rubidium gas cell devices (relatively compact, low-cost frequency standards of modest accuracy and stability) and atomic hydrogen masers (relatively large, high-cost standards of modest accuracy and high stability). 203 refs., 45 figs., 9 tabs.

  5. Soviet precision timekeeping research and technology

    International Nuclear Information System (INIS)

    Vessot, R.F.C.; Allan, D.W.; Crampton, S.J.B.; Cutler, L.S.; Kern, R.H.; McCoubrey, A.O.; White, J.D.

    1991-08-01

    This report is the result of a study of Soviet progress in precision timekeeping research and timekeeping capability during the last two decades. The study was conducted by a panel of seven US scientists who have expertise in timekeeping, frequency control, time dissemination, and the direct applications of these disciplines to scientific investigation. The following topics are addressed in this report: generation of time by atomic clocks at the present level of their technology, new and emerging technologies related to atomic clocks, time and frequency transfer technology, statistical processes involving metrological applications of time and frequency, applications of precise time and frequency to scientific investigations, supporting timekeeping technology, and a comparison of Soviet research efforts with those of the United States and the West. The number of Soviet professionals working in this field is roughly 10 times that in the United States. The Soviet Union has facilities for large-scale production of frequency standards and has concentrated its efforts on developing and producing rubidium gas cell devices (relatively compact, low-cost frequency standards of modest accuracy and stability) and atomic hydrogen masers (relatively large, high-cost standards of modest accuracy and high stability). 203 refs., 45 figs., 9 tabs

  6. High precision timing in a FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Hoek, Matthias; Cardinali, Matteo; Dickescheid, Michael; Schlimme, Soeren; Sfienti, Concettina; Spruck, Bjoern; Thiel, Michaela [Institut fuer Kernphysik, Johannes Gutenberg-Universitaet Mainz (Germany)

    2016-07-01

    A segmented highly precise start counter (FLASH) was designed and constructed at the Institute for Nuclear Physics in Mainz. Besides determining a precise reference time, a Time-of-Flight measurement can be performed with two identical FLASH units. Thus, particle identification can be provided for mixed hadron beam environments. The detector design is based on the detection of Cherenkov light produced in fused silica radiator bars with fast multi-anode MCP-PMTs. The segmentation of the radiator improves the timing resolution while allowing a coarse position resolution along one direction. Both, the arrival time and the Time-over-Threshold are determined by the readout electronics, which enables walk correction of the arrival time. The performance of two FLASH units was investigated in test experiments at the Mainz Microton (MAMI) using an electron beam with an energy of 855 MeV and at CERN's PS T9 beam line with a mixed hadron beam with momenta between 3-8 GeV/c. Effective Time-walk correction methods based on Time-over-Threshold were developed for the data analysis. The achieved Time-Of-Flight resolution after applying all corrections was found to be 70 ps. Furthermore, the PID and position resolution capabilities are discussed in this contribution.

  7. Towards High Productivity in Precision Grinding

    Directory of Open Access Journals (Sweden)

    W. Brian Rowe

    2018-04-01

    Full Text Available Over the last century, substantial advances have been made, based on improved understanding of the requirements of grinding processes, machines, control systems, materials, abrasives, wheel preparation, coolants, lubricants, and coolant delivery. This paper reviews a selection of areas in which the application of scientific principles and engineering ingenuity has led to the development of new grinding processes, abrasives, tools, machines, and systems. Topics feature a selection of areas where relationships between scientific principles and new techniques are yielding improved productivity and better quality. These examples point towards further advances that can fruitfully be pursued. Applications in modern grinding technology range from high-precision kinematics for grinding very large lenses and reflectors through to medium size grinding machine processes and further down to grinding very small components used in micro electro-mechanical systems (MEMS devices. The importance of material issues is emphasized for the range of conventional engineering steels, through to aerospace materials, ceramics, and composites. It is suggested that future advances in productivity will include the wider application of artificial intelligence and robotics to improve precision, process efficiency, and features required to integrate grinding processes into wider manufacturing systems.

  8. Human genomics projects and precision medicine.

    Science.gov (United States)

    Carrasco-Ramiro, F; Peiró-Pastor, R; Aguado, B

    2017-09-01

    The completion of the Human Genome Project (HGP) in 2001 opened the floodgates to a deeper understanding of medicine. There are dozens of HGP-like projects which involve from a few tens to several million genomes currently in progress, which vary from having specialized goals or a more general approach. However, data generation, storage, management and analysis in public and private cloud computing platforms have raised concerns about privacy and security. The knowledge gained from further research has changed the field of genomics and is now slowly permeating into clinical medicine. The new precision (personalized) medicine, where genome sequencing and data analysis are essential components, allows tailored diagnosis and treatment according to the information from the patient's own genome and specific environmental factors. P4 (predictive, preventive, personalized and participatory) medicine is introducing new concepts, challenges and opportunities. This review summarizes current sequencing technologies, concentrates on ongoing human genomics projects, and provides some examples in which precision medicine has already demonstrated clinical impact in diagnosis and/or treatment.

  9. The precise temporal calibration of dinosaur origins.

    Science.gov (United States)

    Marsicano, Claudia A; Irmis, Randall B; Mancuso, Adriana C; Mundil, Roland; Chemale, Farid

    2016-01-19

    Dinosaurs have been major components of ecosystems for over 200 million years. Although different macroevolutionary scenarios exist to explain the Triassic origin and subsequent rise to dominance of dinosaurs and their closest relatives (dinosauromorphs), all lack critical support from a precise biostratigraphically independent temporal framework. The absence of robust geochronologic age control for comparing alternative scenarios makes it impossible to determine if observed faunal differences vary across time, space, or a combination of both. To better constrain the origin of dinosaurs, we produced radioisotopic ages for the Argentinian Chañares Formation, which preserves a quintessential assemblage of dinosaurian precursors (early dinosauromorphs) just before the first dinosaurs. Our new high-precision chemical abrasion thermal ionization mass spectrometry (CA-TIMS) U-Pb zircon ages reveal that the assemblage is early Carnian (early Late Triassic), 5- to 10-Ma younger than previously thought. Combined with other geochronologic data from the same basin, we constrain the rate of dinosaur origins, demonstrating their relatively rapid origin in a less than 5-Ma interval, thus halving the temporal gap between assemblages containing only dinosaur precursors and those with early dinosaurs. After their origin, dinosaurs only gradually dominated mid- to high-latitude terrestrial ecosystems millions of years later, closer to the Triassic-Jurassic boundary.

  10. Multineuronal Spike Sequences Repeat with Millisecond Precision

    Directory of Open Access Journals (Sweden)

    Koki eMatsumoto

    2013-06-01

    Full Text Available Cortical microcircuits are nonrandomly wired by neurons. As a natural consequence, spikes emitted by microcircuits are also nonrandomly patterned in time and space. One of the prominent spike organizations is a repetition of fixed patterns of spike series across multiple neurons. However, several questions remain unsolved, including how precisely spike sequences repeat, how the sequences are spatially organized, how many neurons participate in sequences, and how different sequences are functionally linked. To address these questions, we monitored spontaneous spikes of hippocampal CA3 neurons ex vivo using a high-speed functional multineuron calcium imaging technique that allowed us to monitor spikes with millisecond resolution and to record the location of spiking and nonspiking neurons. Multineuronal spike sequences were overrepresented in spontaneous activity compared to the statistical chance level. Approximately 75% of neurons participated in at least one sequence during our observation period. The participants were sparsely dispersed and did not show specific spatial organization. The number of sequences relative to the chance level decreased when larger time frames were used to detect sequences. Thus, sequences were precise at the millisecond level. Sequences often shared common spikes with other sequences; parts of sequences were subsequently relayed by following sequences, generating complex chains of multiple sequences.

  11. Precision of hyaline cartilage thickness measurements

    Energy Technology Data Exchange (ETDEWEB)

    Jonsson, K.; Buckwalter, K.; Helvie, M.; Niklason, L.; Martel, W. (Univ. of Michigan Hospitals, Ann Arbor, MI (United States). Dept. of Radiology)

    1992-05-01

    Measurement of cartilage thickness in vivo is an important indicator of the status of a joint as the various degenerative and inflammatory arthritides directly affect the condition of the cartilage. In order to assess the precision of thickness measurements of hyaline articular cartilage, we undertook a pilot study using MR imaging, plain radiography, and ultrasonography (US). We measured the cartilage of the hip and knee joints in 10 persons (4 healthy volunteers and 6 patients). The joints in each patient were examined on two separate occasions using each modality. In the hips a swell as the knee joints, the most precise measuring method was plain film radiography. For radiographs of the knees obtained in the standing position, the coefficient of variation was 6.5%; in the hips this figure was 6.34%. US of the knees and MR imaging of the hips were the second best modalities in the measurement of cartilage thickness. In addition, MR imaging enabled the most complete visualization of the joint cartilage. (orig.).

  12. Astrometria diferencial de precision con VLBI el triangulo de Draco (y estudios de SN1993J)

    Science.gov (United States)

    Ros, E.

    1997-11-01

    The Very Long Baseline Interferometry (VLBI) technique provides unprecedented resolutions in astronomy. In this PhD we show progress in the study of high precision phase-delay differential astrometry through observations of the radio source triangle formed by the BL-Lac objects 1803+784 and 2007+777, and the QSO 1928+738, in the Northern constellation of Draco (the Dragon), from observations carried out on 20/21 November 1991 with an intercontinental interferometric array simultaneously at the frequencies of 2.3 and 8.4 GHz. We have determined the angular separations among the three radio sources with submilliarcsecond accuracy from a weighted least squares analysis of the differential phase delay from the three celestial bodies. Our present work introduces important advances with respect to previous astrometric studies, carried out over radio source pairs separated by smaller angular distances. We have consistently modeled the parameters involved in an astrometric VLBI observation, in order to reproduce the differential phase observed for radio sources separated by almost 7o on the sky. We have demonstrated the possibility of phase-connection over these angular distances at 8.4 GHz, even at an epoch of a maximum in the solar activity. After the phase-connection we have corrected the effects of the extended structure of the radio source and of the ionosphere. This last correction is one of the main technical achievements of this thesis: it is possible to remove the ionospheric contribution with independent measurements of the ionosphere total electron content obtained at Global Positioning Systems (GPS) sites the VLBI observing stations. The triangular geometry introduces constraints in parameter space that allow a better estimation of the angular separations among the radio sources. It is possible to test the consistency of the astrometric results through the Sky-Closure, defined as the circular sum of the angular separations of the three radio sources, determined

  13. Precision wildlife medicine: applications of the human-centred precision medicine revolution to species conservation.

    Science.gov (United States)

    Whilde, Jenny; Martindale, Mark Q; Duffy, David J

    2017-05-01

    The current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human-induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting in reduced genetic variation are accelerating disease emergence. Novel, efficient and effective approaches are required to combat these epizootic events. Here, we present the case for the application of human precision medicine approaches to wildlife medicine in order to enhance species conservation efforts. We consider how the precision medicine revolution, coupled with the advances made in genomics, may provide a powerful and feasible approach to identifying and treating wildlife diseases in a targeted, effective and streamlined manner. A number of case studies of threatened species are presented which demonstrate the applicability of precision medicine to wildlife conservation, including sea turtles, amphibians and Tasmanian devils. These examples show how species conservation could be improved by using precision medicine techniques to determine novel treatments and management strategies for the specific medical conditions hampering efforts to restore population levels. Additionally, a precision medicine approach to wildlife health has in turn the potential to provide deeper insights into human health and the possibility of stemming and alleviating the impacts of zoonotic diseases. The integration of the currently emerging Precision Medicine Initiative with the concepts of EcoHealth (aiming for sustainable health of people, animals and ecosystems through transdisciplinary action research) and One Health (recognizing the intimate connection of humans, animal and ecosystem health and addressing a wide range of risks at the animal-human-ecosystem interface through a coordinated, collaborative, interdisciplinary approach) has great potential to deliver a deeper and broader interdisciplinary-based understanding of both wildlife and human

  14. Sensing Characteristics of A Precision Aligner Using Moire Gratings for Precision Alignment System

    Institute of Scientific and Technical Information of China (English)

    ZHOU Lizhong; Hideo Furuhashi; Yoshiyuki Uchida

    2001-01-01

    Sensing characteristics of a precision aligner using moire gratings for precision alignment sysem has been investigated. A differential moire alignment system and a modified alignment system were used. The influence of the setting accuracy of the gap length and inclination of gratings on the alignment accuracy has been studied experimentally and theoretically. Setting accuracy of the gap length less than 2.5μm is required in modified moire alignment. There is no influence of the gap length on the alignment accuracy in the differential alignment system. The inclination affects alignment accuracies in both differential and modified moire alignment systems.

  15. Finishing of precision generated metal optical components

    International Nuclear Information System (INIS)

    Baker, P.C.; Sonderman, J.B.

    1975-08-01

    Diamond turning and precision generation of aspheric metal surfaces has promoted a change in lapping techniques due to the extremely close figure tolerances and surface finishes that have been achieved. Special tooling, diamond abrasive, silicon oil and special techniques used to polish the unusual aspheric figures are described. The studies include small flat diamond turned samples of copper, electroplated copper, electroplated silver, electroplated nickel and silver as well as large aspheres such as an f/0.75, 35 cm dia copper ellipse. Results from cleaning studies on flat samples using ultrasonics and vapor degreasers are also summarized. Interferograms of wavefront distortion and analysis of focal volume are included as well as 10.6 μm reflectivity and a summary of laser damage experiments. (TFD)

  16. Precision cosmology the first half million years

    CERN Document Server

    Jones, Bernard J T

    2017-01-01

    Cosmology seeks to characterise our Universe in terms of models based on well-understood and tested physics. Today we know our Universe with a precision that once would have been unthinkable. This book develops the entire mathematical, physical and statistical framework within which this has been achieved. It tells the story of how we arrive at our profound conclusions, starting from the early twentieth century and following developments up to the latest data analysis of big astronomical datasets. It provides an enlightening description of the mathematical, physical and statistical basis for understanding and interpreting the results of key space- and ground-based data. Subjects covered include general relativity, cosmological models, the inhomogeneous Universe, physics of the cosmic background radiation, and methods and results of data analysis. Extensive online supplementary notes, exercises, teaching materials, and exercises in Python make this the perfect companion for researchers, teachers and students i...

  17. Sfermion Precision Measurements at a Linear Collider

    CERN Document Server

    Freitas, A.; Ananthanarayan, B.; Bartl, A.; Blair, G.A.; Blochinger, C.; Boos, E.; Brandenburg, A.; Datta, A.; Djouadi, A.; Fraas, H.; Guasch, J.; Hesselbach, S.; Hidaka, K.; Hollik, W.; Kernreiter, T.; Maniatis, M.; von Manteuffel, A.; Martyn, H.U.; Miller, D.J.; Moortgat-Pick, Gudrid A.; Muhlleitner, M.; Nauenberg, U.; Kluge, Hannelies; Porod, W.; Sola, J.; Sopczak, A.; Stahl, A.; Weber, M.M.; Zerwas, P.M.

    2002-01-01

    At future e+- e- linear colliders, the event rates and clean signals of scalar fermion production - in particular for the scalar leptons - allow very precise measurements of their masses and couplings and the determination of their quantum numbers. Various methods are proposed for extracting these parameters from the data at the sfermion thresholds and in the continuum. At the same time, NLO radiative corrections and non-zero width effects have been calculated in order to match the experimental accuracy. The substantial mixing expected for the third generation sfermions opens up additional opportunities. Techniques are presented for determining potential CP-violating phases and for extracting tan(beta) from the stau sector, in particular at high values. The consequences of possible large mass differences in the stop and sbottom system are explored in dedicated analyses.

  18. Electroweak Precision Measurements with the ATLAS Detector

    CERN Document Server

    Zhang, Zhiqing; The ATLAS collaboration

    2018-01-01

    With the high integrated luminosities recorded at the LHC and the very good understanding of the ATLAS detector, it is possible to measure electroweak observables to the highest precision. In this talk, we present the tau polarisation, measured in $Z\\to \\tau\\tau$ using 20.3 fb$^{-1}$ of proton proton collision data collected at a centre of mass energy of 8 TeV. The talk also reviews the measurement of forward-background asymmetry based on the triple differential Drell-Yan cross-section obtained with the same data sample, which can be used to extract the weak mixing angle. We conclude with a presentation of the measurement of the $W$-boson mass using 4.6 fb$^{-1}$ data, collected at 7 TeV.

  19. Electroweak effective couplings for future precision experiments

    International Nuclear Information System (INIS)

    Jegerlehner, F.

    2011-01-01

    The leading hadronic effects in electroweak theory derive from vacuum polarization which are non-perturbative hadronic contributions to the running of the gauge couplings, the electromagnetic α em (s)and the SU(2) L coupling α 2 (s). I will report on my recent package alphaQED, which besides the effective fine structure constant α em (s) also allows for a fairly precise calculation of the SU(2) L gauge coupling α 2 (s). I will briefly review the role, future requirements and possibilities. Applied together with the R had package by Harlander and Steinhauser, the package allows to calculate all SM running couplings as well as running sin 2 Θ versions with state-of-the-art accuracy.

  20. Electroweak effective couplings for future precision experiments

    International Nuclear Information System (INIS)

    Jegerlehner, F.; Humboldt-Universitaet, Berlin

    2011-07-01

    The leading hadronic effects in electroweak theory derive from vacuum polarization which are non-perturbative hadronic contributions to the running of the gauge couplings, the electromagnetic α em (s) and the SU(2) L coupling α 2 (s). I report on my recent package alphaQED [1], which besides the effective fine structure constant α em (s) also allows for a fairly precise calculation of the SU(2) L gauge coupling α 2 (s). I will briefly review the role, future requirements and possibilities. Applied together with the Rhad package by Harlander and Steinhauser [2], the package allows to calculate all SM running couplings as well as running sin 2 Θ versions with state-of-the-art accuracy. (orig.)

  1. Wet drift chambers for precise luminosity

    International Nuclear Information System (INIS)

    Anderson, B.E.; Kennedy, B.W.; Ahmet, K.; Attree, D.J.; Barraclough, G.A.; Cresswell, M.J.; Hayes, D.A.; Miller, D.J.; Selby, C.; Sherwood, P.

    1994-01-01

    A set of high-precision compact drift chambers has been a vital component of the OPAL luminosity monitor since the start of data-taking at LEP. They were augmented in 1992 by the addition of Small Angle Reference Chambers with a very similar design to the original chamber. The performance of the chambers is reviewed, highlighting both the importance of using polyalkylene glycol (Breox) to maintain a uniform and parallel electric field and the construction techniques used to sustain the required field strength. We describe some of the operating problems, with their solutions, and show how the chambers have been used in achieving a systematic error of 0.41% on the luminosity measurement. ((orig.))

  2. Precise delay measurement through combinatorial logic

    Science.gov (United States)

    Burke, Gary R. (Inventor); Chen, Yuan (Inventor); Sheldon, Douglas J. (Inventor)

    2010-01-01

    A high resolution circuit and method for facilitating precise measurement of on-chip delays for FPGAs for reliability studies. The circuit embeds a pulse generator on an FPGA chip having one or more groups of LUTS (the "LUT delay chain"), also on-chip. The circuit also embeds a pulse width measurement circuit on-chip, and measures the duration of the generated pulse through the delay chain. The pulse width of the output pulse represents the delay through the delay chain without any I/O delay. The pulse width measurement circuit uses an additional asynchronous clock autonomous from the main clock and the FPGA propagation delay can be displayed on a hex display continuously for testing purposes.

  3. PRECISE COSMIC RAYS MEASUREMENTS WITH PAMELA

    Directory of Open Access Journals (Sweden)

    A. Bruno

    2013-12-01

    Full Text Available The PAMELA experiment was launched on board the Resurs-DK1 satellite on June 15th 2006. The apparatus was designed to conduct precision studies of charged cosmic radiation over a wide energy range, from tens of MeV up to several hundred GeV, with unprecedented statistics. In five years of continuous data taking in space, PAMELA accurately measured the energy spectra of cosmic ray antiprotons and positrons, as well as protons, electrons and light nuclei, sometimes providing data in unexplored energetic regions. These important results have shed new light in several astrophysical fields like: an indirect search for Dark Matter, a search for cosmological antimatter (anti-Helium, and the validation of acceleration, transport and secondary production models of cosmic rays in the Galaxy. Some of the most important items of Solar and Magnetospheric physics were also investigated. Here we present the most recent results obtained by the PAMELA experiment.

  4. Digitalization of highly precise fluxgate magnetometers

    DEFF Research Database (Denmark)

    Cerman, Ales; Kuna, A.; Ripka, P.

    2005-01-01

    This paper describes the theory behind all three known ways of digitalizing the fluxgate magnetometers: analogue magnetometers with digitalized output using high resolution ADC, application of the delta-sigma modulation to the sensor feedback loop and fully digital signal detection. At present time...... the Delta-Sigma ADCs are mostly used for the digitalization of the highly precise fluxgate magnetorneters. The relevant part of the paper demonstrates some pitfalls of their application studied during the design of the magnetometer for the new Czech scientific satellite MIMOSA. The part discussing...... the application of the A-E modulation to the sensor feedback loop theoretically derives the main advantage of this method-increasing of the modulation order and shows its real potential compared to the analog magnetometer with consequential digitalization. The comparison is realized on the modular magnetometer...

  5. Precision diamond grinding of ceramics and glass

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S.; Paul, H.; Scattergood, R.O.

    1988-12-01

    A new research initiative will be undertaken to investigate the effect of machine parameters and material properties on precision diamond grinding of ceramics and glass. The critical grinding depth to initiate the plastic flow-to-brittle fracture regime will be directly measured using plunge-grind tests. This information will be correlated with machine parameters such as wheel bonding and diamond grain size. Multiaxis grinding tests will then be made to provide data more closely coupled with production technology. One important aspect of the material property studies involves measuring fracture toughness at the very short crack sizes commensurate with grinding damage. Short crack toughness value`s can be much less than the long-crack toughness values measured in conventional fracture tests.

  6. The Precision Problem in Conservation and Restoration.

    Science.gov (United States)

    Hiers, J Kevin; Jackson, Stephen T; Hobbs, Richard J; Bernhardt, Emily S; Valentine, Leonie E

    2016-11-01

    Within the varied contexts of environmental policy, conservation of imperilled species populations, and restoration of damaged habitats, an emphasis on idealized optimal conditions has led to increasingly specific targets for management. Overly-precise conservation targets can reduce habitat variability at multiple scales, with unintended consequences for future ecological resilience. We describe this dilemma in the context of endangered species management, stream restoration, and climate-change adaptation. Inappropriate application of conservation targets can be expensive, with marginal conservation benefit. Reduced habitat variability can limit options for managers trying to balance competing objectives with limited resources. Conservation policies should embrace habitat variability, expand decision-space appropriately, and support adaptation to local circumstances to increase ecological resilience in a rapidly changing world. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Atomic physics precise measurements and ultracold matter

    CERN Document Server

    Inguscio, Massimo

    2013-01-01

    Atomic Physics provides an expert guide to two spectacular new landscapes in physics: precision measurements, which have been revolutionized by the advent of the optical frequency comb, and atomic physics, which has been revolutionized by laser cooling. These advances are not incremental but transformative: they have generated a consilience between atomic and many-body physics, precipitated an explosion of scientific and technological applications, opened new areas of research, and attracted a brilliant generation of younger scientists. The research is advancing so rapidly, the barrage of applications is so dazzling, that students can be bewildered. For both students and experienced scientists, this book provides an invaluable description of basic principles, experimental methods, and scientific applications.

  8. Electroweak Precision Measurements with the ATLAS Detector

    CERN Document Server

    Zhang, Zhiqing; The ATLAS collaboration

    2018-01-01

    With the high integrated luminosities recorded at the LHC and the very good understanding of the ATLAS detector, it is possible to measure electroweak observables to the highest precision. In this talk, we review the measurement of the W boson mass using data, collected at 7 TeV. Special focus is drawn on a discussion of the modeling uncertainties and the physics potential of the latest low-mu runs, recorded at a center of mass energy of 5 and 13 TeV at the end of 2017. The talk will also review the measurement of the triple differential Drell-Yan cross-section at 8 TeV, which can be used to extract the weak mixing angle. We conclude with a presentation of the tau polarization, measured in Z->tautau using 20.3/fb of proton proton collision data collected at a center of mass energy of 8 TeV.

  9. Micropropulsion Systems for Precision Controlled Space Flight

    DEFF Research Database (Denmark)

    Larsen, Jack

    . This project is thus concentrating on developing a method by which an entire, ecient, control system compensating for the disturbances from the space environment and thereby enabling precision formation flight can be realized. The space environment is initially studied and the knowledge gained is used......Space science is subject to a constantly increasing demand for larger coherence lengths or apertures of the space observation systems, which in turn translates into a demand for increased dimensions and subsequently cost and complexity of the systems. When this increasing demand reaches...... the pratical limitations of increasing the physical dimensions of the spacecrafts, the observation platforms will have to be distributed on more spacecrafts flying in very accurate formations. Consequently, the observation platform becomes much more sensitive to disturbances from the space environment...

  10. Precise mass detector based on carbon nanooscillator

    Energy Technology Data Exchange (ETDEWEB)

    Lukashenko, S., E-mail: lukashenko13@mail.ru; Golubok, A. [Department of Nanotechnology and Material Science, ITMO University, Kronverskiy av. 49, 192000, St. Petersburg (Russian Federation); Institute for Analytical Instrumentation of RAS, Rizhsky pr 26, St. Petersburg, 190103 (Russian Federation); Komissarenko, F. [Department of Nanotechnology and Material Science, ITMO University, Kronverskiy av. 49, 192000, St. Petersburg (Russian Federation); Academic University, Russian Academy of Sciences, ul. Khlopina 8/3, 194021, St. Petersburg (Russian Federation); Mukhin, I. [Academic University, Russian Academy of Sciences, ul. Khlopina 8/3, 194021, St. Petersburg (Russian Federation); Sapozhnikov, I. [Institute for Analytical Instrumentation of RAS, Rizhsky pr 26, St. Petersburg, 190103 (Russian Federation); Veniaminov, A. [Centre for Information Optical Technologies, ITMO University, Birzhevaya ln. 14-16, 199034, St. Petersburg (Russian Federation); Lysak, V. [Department of Nanotechnology and Material Science, ITMO University, Kronverskiy av. 49, 192000, St. Petersburg (Russian Federation)

    2016-06-17

    Precise mass detectors based on an amorphous carbon nanowires, which localized on the top of a tungsten tip were fabricated and investigated. The nanowires were grown in the scanning electron microscope (SEM) chamber using focused electron beam technique. The movement trajectories and amplitude-frequency characteristics of the carbon nanowire oscillators were visualized at low and ambient pressure using SEM and confocal laser scanning microscope (CLSM), respectevely. The SiO{sub 2} and TiO{sub 2} nanospheres were clamped on the top of the carbon nanowires. The manipulations of nanospheres were provided by means of dielectrophoretic force in SEM. The sensitivity of the mass detector based on the carbon nanowire oscillator was estimated.

  11. Atomic precision tests and light scalar couplings

    Energy Technology Data Exchange (ETDEWEB)

    Brax, Philippe [CEA, IPhT, CNRS, URA 2306, Gif-sur-Yvette (France). Inst. de Physique Theorique; Burrage, Clare [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Geneve Univ. (Switzerland). Dept. de Physique Theorique

    2010-10-15

    We calculate the shift in the atomic energy levels induced by the presence of a scalar field which couples to matter and photons. We find that a combination of atomic measurements can be used to probe both these couplings independently. A new and stringent bound on the matter coupling springs from the precise measurement of the 1s to 2s energy level difference in the hydrogen atom, while the coupling to photons is essentially constrained by the Lamb shift. Combining these constraints with current particle physics bounds we find that the contribution of a scalar field to the recently claimed discrepancy in the proton radius measured using electronic and muonic atoms is negligible. (orig.)

  12. Precision Cosmology: The First Half Million Years

    Science.gov (United States)

    Jones, Bernard J. T.

    2017-06-01

    Cosmology seeks to characterise our Universe in terms of models based on well-understood and tested physics. Today we know our Universe with a precision that once would have been unthinkable. This book develops the entire mathematical, physical and statistical framework within which this has been achieved. It tells the story of how we arrive at our profound conclusions, starting from the early twentieth century and following developments up to the latest data analysis of big astronomical datasets. It provides an enlightening description of the mathematical, physical and statistical basis for understanding and interpreting the results of key space- and ground-based data. Subjects covered include general relativity, cosmological models, the inhomogeneous Universe, physics of the cosmic background radiation, and methods and results of data analysis. Extensive online supplementary notes, exercises, teaching materials, and exercises in Python make this the perfect companion for researchers, teachers and students in physics, mathematics, and astrophysics.

  13. Precise linear gating circuit on integrated microcircuits

    Energy Technology Data Exchange (ETDEWEB)

    Butskii, V.V.; Vetokhin, S.S.; Reznikov, I.V.

    Precise linear gating circuit on four microcircuits is described. A basic flowsheet of the gating circuit is given. The gating circuit consists of two input differential cascades total load of which is two current followers possessing low input and high output resistances. Follower outlets are connected to high ohmic dynamic load formed with a current source which permits to get high amplification (>1000) at one cascade. Nonlinearity amounts to <0.1% in the range of input signal amplitudes of -10-+10 V. Front duration for an output signal with 10 V amplitude amounts to 100 ns. Attenuation of input signal with a closed gating circuit is 60 db. The gating circuits described is used in the device intended for processing of scintillation sensor signals.

  14. Precision Continuum Receivers for Astrophysical Applications

    Science.gov (United States)

    Wollack, Edward J.

    2011-01-01

    Cryogenically cooled HEMT (High Electron Mobility Transistor) amplifiers find widespread use in radioastronomy receivers. In recent years, these devices have also been commonly employed in broadband receivers for precision measurements of the Cosmic Microwave Background (CMB) radiation. In this setting, the combination of ultra-low-noise and low-spectral-resolution observations reinforce the importance achieving suitable control over the device environment to achieve fundamentally limited receiver performance. The influence of the intrinsic amplifier stability at low frequencies on data quality (e.g., achievable noise and residual temporal correlations), observational and calibration strategies, as well as architectural mitigation approaches in this setting will be discussed. The implications of device level 1/f fluctuations reported in the literature on system performance will be reviewed.

  15. Sfermion precision measurements at a linear collider

    International Nuclear Information System (INIS)

    Freitas, A.; Ananthanarayan, B.; Bartl, A.; Blair, G.; Bloechinger, C.; Boos, E.; Brandenburg, A.; Datta, A.; Djouadi, A.; Fraas, H.; Guasch, J.; Hesselbach, S.; Hidaka, K.; Hollik, W.; Kernreiter, T.; Maniatis, M.; Manteuffel, A. von; Martyn, H.-U.; Miller, D.J.; Moortgat-Pick, G.; Muehlleitner, M.; Nauenberg, U.; Nowak, H.; Porod, W.; Sola, J.; Sopczak, A.; Stahl, A.; Weber, M.M.; Zerwas, P.M.

    2003-01-01

    At prospective e ± e - linear colliders, the large cross-sections and clean signals of scalar fermion production--in particular for the scalar leptons - allow very precise measurements of their masses and couplings and the determination of their quantum numbers. Various methods are proposed for extracting these parameters from the data at the sfermion thresholds and in the continuum. At the same time, NLO radiative corrections and non-zero width effects have been calculated in order to match the experimental accuracy. The substantial mixing expected in the third generation opens up additional opportunities. Techniques are presented for determining potential CP-violating phases and for extracting tan β from the stau sector, in particular at high values. The consequences of possible large mass differences in the stop and sbottom system are explored in dedicated analyses

  16. Sfermion precision measurements at a linear collider

    International Nuclear Information System (INIS)

    Freitas, A.

    2003-01-01

    At future e + e - linear colliders, the event rates and clean signals of scalar fermion production--in particular for the scalar leptons--allow very precise measurements of their masses and couplings and the determination of their quantum numbers. Various methods are proposed for extracting these parameters from the data at the sfermion thresholds and in the continuum. At the same time, NLO radiative corrections and non-zero width effects have been calculated in order to match the experimental accuracy. The substantial mixing expected for the third generation sfermions opens up additional opportunities. Techniques are presented for determining potential CP-violating phases and for extracting tan β from the stau sector, in particular at high values. The consequences of possible large mass differences in the stop and sbottom system are explored in dedicated analyses

  17. Precise documentation of well-structured programs

    Energy Technology Data Exchange (ETDEWEB)

    Parnas, D.L.; Madey, J.; Iglewski, M. [McMaster Univ., Hamilton, Ontario (Canada)

    1997-11-01

    This paper describes a new form of program documentation that is precise, systematic and readable. This documentation comprises a set of displays supplemented by a lexicon and an index. Each display presents a program fragment in such a way that its correctness can be examined without looking at any other display. Each display has three parts: (1) the specification of the program presented in the display, (2) the program itself, and (3) the specifications of programs invoked by this program. The displays are intended to be used by Software Engineers as a reference document during inspection and maintenance. This paper also introduces a specification technique that is a refinement of Mills functional approach to program documentation and verification; programs are specified and described in tabular form.

  18. Standardized precision radiotherapy in choroidal metastases

    International Nuclear Information System (INIS)

    Nylen, U.; Kock, E.; Lax, I.; Lundell, G.; Trampe, E. af; Wilking, N.

    1994-01-01

    Metastases in the choroid of the eye are frequent in patients with disseminated malignancy. We here report the results using the precision radiotherapy technique described by Schipper et al. to treat 14 of 17 consecutive patients (21 eyes) with symptoms from such metastases. A beam defining collimator was used and a lateral field was given with the treated eye individually fixed. Varying fractionations and doses were used. The biologically effective dose for early effects (BED 3 ) was 47 to 90 Gy and for late effects (BED 10 ) 28 to 59 Gy. In 14 eyes (82%) the metastases regressed completely. The visual acuity was stabilized or improved in all patients and none needed local surgery. Three patients developed signs of radiation retinopathy, but only in one case the visual function was compromized. With this standardized technique no individualized dose planning was needed, the risk of radiation cataract was minimized and a dry eye avoided. (orig.)

  19. A precise extragalactic test of General Relativity.

    Science.gov (United States)

    Collett, Thomas E; Oldham, Lindsay J; Smith, Russell J; Auger, Matthew W; Westfall, Kyle B; Bacon, David; Nichol, Robert C; Masters, Karen L; Koyama, Kazuya; van den Bosch, Remco

    2018-06-22

    Einstein's theory of gravity, General Relativity, has been precisely tested on Solar System scales, but the long-range nature of gravity is still poorly constrained. The nearby strong gravitational lens ESO 325-G004 provides a laboratory to probe the weak-field regime of gravity and measure the spatial curvature generated per unit mass, γ. By reconstructing the observed light profile of the lensed arcs and the observed spatially resolved stellar kinematics with a single self-consistent model, we conclude that γ = 0.97 ± 0.09 at 68% confidence. Our result is consistent with the prediction of 1 from General Relativity and provides a strong extragalactic constraint on the weak-field metric of gravity. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  20. The precision problem in conservation and restoration

    Science.gov (United States)

    Hiers, J. Kevin; Jackson, Stephen T.; Hobbs, Richard J.; Bernhardt, Emily S.; Valentine, Leonie E.

    2016-01-01

    Within the varied contexts of environmental policy, conservation of imperilled species populations, and restoration of damaged habitats, an emphasis on idealized optimal conditions has led to increasingly specific targets for management. Overly-precise conservation targets can reduce habitat variability at multiple scales, with unintended consequences for future ecological resilience. We describe this dilemma in the context of endangered species management, stream restoration, and climate-change adaptation. Inappropriate application of conservation targets can be expensive, with marginal conservation benefit. Reduced habitat variability can limit options for managers trying to balance competing objectives with limited resources. Conservation policies should embrace habitat variability, expand decision-space appropriately, and support adaptation to local circumstances to increase ecological resilience in a rapidly changing world.

  1. Analysis of Hall Probe Precise Positioning with Cylindrical Permanent Magnet

    International Nuclear Information System (INIS)

    Belicev, P.; Vorozhtsov, A.S.; Vorozhtsov, S.B.

    2007-01-01

    Precise positioning of a Hall probe for cyclotron magnetic field mapping, using cylindrical permanent magnets, was analyzed. The necessary permanent magnet parameters in order to achieve ±20 μm position precision, were determined. (author)

  2. High precision relative position sensing system for formation flying spacecraft

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop and test an optical sensing system that provides high precision relative position sensing for formation flying spacecraft.  A high precision...

  3. CubeSat Handling of Multisystem Precision Time Transfer (CHOMPTT)

    Data.gov (United States)

    National Aeronautics and Space Administration — The CubeSat Handling of Multisystem Precision Time Transfer (CHOMPTT) mission is a precision timing satellite equipped with atomic clocks synchronized with a ground...

  4. Surviving With Smog and Smoke: Precision Interventions?

    Science.gov (United States)

    Cai, Hua; Wang, Chen

    2017-11-01

    Despite continuous efforts of regional governmental agencies, air pollution remains a major threat to public health worldwide. In January 2017, a severe episode of smog similar to the Great Smog of 1952 occurred in London. The longest episode of Chinese haze also developed in Beijing, during which levels of particulate matter smog and Chinese haze are associated with large numbers of premature deaths each year, at 400,000 and 1.2 million, respectively, primarily from respiratory diseases, cerebrovascular diseases, and ischemic heart diseases. In addition to air pollution, some are exposed to other harmful environmental factors, such as secondhand smoke. For countries with large populations of smokers, such as China, India, the United States, and Russia, surviving both smog and smoke is a serious problem. With novel genomic and epigenomic studies revealing air pollution- and smoking-induced mutational signatures and epigenetic editing in diseases such as lung cancer, it has become feasible to develop precision strategies for early intervention in the disease-causing pathways driven by the specific mutations or epigenetic regulations, or both. New therapies guided by gene-drug interactions and genomic biomarkers may also be developed. We discuss both perspectives regarding the urgent need to manage the toxic effects of smog and smoke for the benefit of global health and the novel concept of precision intervention to protect the exposed individuals when exposure to smog and secondhand smoke cannot be voluntarily avoided or easily modified. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  5. Precise Masses in the WASP-47 System

    Science.gov (United States)

    Vanderburg, Andrew; Becker, Juliette C.; Buchhave, Lars A.; Mortier, Annelies; Lopez, Eric; Malavolta, Luca; Haywood, Raphaëlle D.; Latham, David W.; Charbonneau, David; López-Morales, Mercedes; Adams, Fred C.; Bonomo, Aldo Stefano; Bouchy, François; Collier Cameron, Andrew; Cosentino, Rosario; Di Fabrizio, Luca; Dumusque, Xavier; Fiorenzano, Aldo; Harutyunyan, Avet; Johnson, John Asher; Lorenzi, Vania; Lovis, Christophe; Mayor, Michel; Micela, Giusi; Molinari, Emilio; Pedani, Marco; Pepe, Francesco; Piotto, Giampaolo; Phillips, David; Rice, Ken; Sasselov, Dimitar; Ségransan, Damien; Sozzetti, Alessandro; Udry, Stéphane; Watson, Chris

    2017-12-01

    We present precise radial velocity observations of WASP-47, a star known to host a hot Jupiter, a distant Jovian companion, and, uniquely, two additional transiting planets in short-period orbits: a super-Earth in a ≈19 hr orbit, and a Neptune in a ≈9 day orbit. We analyze our observations from the HARPS-N spectrograph along with previously published data to measure the most precise planet masses yet for this system. When combined with new stellar parameters and reanalyzed transit photometry, our mass measurements place strong constraints on the compositions of the two small planets. We find that, unlike most other ultra-short-period planets, the inner planet, WASP-47 e, has a mass (6.83 ± 0.66 {M}\\oplus ) and a radius (1.810 ± 0.027 {R}\\oplus ) that are inconsistent with an Earth-like composition. Instead, WASP-47 e likely has a volatile-rich envelope surrounding an Earth-like core and mantle. We also perform a dynamical analysis to constrain the orbital inclination of WASP-47 c, the outer Jovian planet. This planet likely orbits close to the plane of the inner three planets, suggesting a quiet dynamical history for the system. Our dynamical constraints also imply that WASP-47 c is much more likely to transit than a geometric calculation would suggest. We calculate a transit probability for WASP-47 c of about 10%, more than an order of magnitude larger than the geometric transit probability of 0.6%.

  6. High precision neutron polarization for PERC

    International Nuclear Information System (INIS)

    Klauser, C.

    2013-01-01

    The decay of the free neutron into a proton, an electron and an anti-electron neutrino offers a simple system to study the semi-leptonic weak decay. High precision measurements of angular correlation coefficients of this decay provide the opportunity to test the standard model on the low energy frontier. The Proton Electron Radiation Channel PERC is part of a new generation of expriments pushing the accuracy of such an angular correlation coefficient measurement towards 10 -4 . Past experiments have been limited to an accuracy of 10 -3 with uncertainties on the neutron polarization as one of the leading systematic errors. This thesis focuses on the development of a stable, highly precise neutron polarization for a large, divergent cold neutron beam. A diagnostic tool that provides polarization higher than 99.99 % and analyzes with an accuracy of 10 -4 , the Opaque Test Bench, is presented and validated. It consists of two highly opaque polarized helium cells. The Opaque Test Bench reveals depolarizing effects in polarizing supermirrors commonly used for polarization in neutron decay experiments. These effects are investigated in detail. They are due to imperfect lateral magnetization in supermirror layers and can be minimized by significantly increased magnetizing fields and low incidence angle and supermirror factor m. A subsequent test in the crossed (X-SM) geometry demonstrated polarizations up to 99.97% from supermirrors only, improving neutron polarization with supermirrors by an order of magnitude. The thesis also discusses other neutron optical components of the PERC beamline: Monte-Carlo simulations of the beamline under consideration of the primary guide are carried out. In addition, calculation shows that PERC would statistically profit from an installation at the European Spallation source. Furthermore, beamline components were tested. A radio-frequency spin flipper was confirmed to work with an efficiency higher than 0.9999. (author) [de

  7. The QCD coupling and parton distributions at high precision

    International Nuclear Information System (INIS)

    Bluemlein, Johannes

    2010-07-01

    A survey is given on the present status of the nucleon parton distributions and related precision calculations and precision measurements of the strong coupling constant α s (M 2 Z ). We also discuss the impact of these quantities on precision observables at hadron colliders. (orig.)

  8. The QCD coupling and parton distributions at high precision

    Energy Technology Data Exchange (ETDEWEB)

    Bluemlein, Johannes

    2010-07-15

    A survey is given on the present status of the nucleon parton distributions and related precision calculations and precision measurements of the strong coupling constant {alpha}{sub s}(M{sup 2}{sub Z}). We also discuss the impact of these quantities on precision observables at hadron colliders. (orig.)

  9. Combining within and between instrument information to estimate precision

    International Nuclear Information System (INIS)

    Jost, J.W.; Devary, J.L.; Ward, J.E.

    1980-01-01

    When two instruments, both having replicated measurements, are used to measure the same set of items, between instrument information may be used to augment the within instrument precision estimate. A method is presented which combines the within and between instrument information to obtain an unbiased and minimum variance estimate of instrument precision. The method does not assume the instruments have equal precision

  10. Factors affecting the precision of bone mineral measurements

    International Nuclear Information System (INIS)

    Cormack, J.; Evil, C.A.

    1990-01-01

    This paper discusses some statistical aspects of absorptiometric bone mineral measurements. In particular, the contribution of photon counting statistics to overall precision is estimated, and methods available for carrying out statistical comparisons of bone loss and determining their precision are reviewed. The use of replicate measurements as a means of improving measurement precision is also discussed. 11 refs

  11. Maser observation in VY CMa with VERA

    Science.gov (United States)

    Choi, Yoon Kyung

    We present the results of multi-epoch VERA (VLBI Exploration of Radio Astrometry) observations of H2O masers at 22 GHz and ^28SiO masers at 43 GHz in the supergiant VY Canis Majoris (hereafter, VY CMa). We estimate the inner motion of H2O masers over 6 months and that of SiO masers over 1 month. Using the inner motion, we calculated the statistical parallax of VY CMa. The size of the emitting region for ^28SiO masers is R_SiO ~1.81-2.89 R_* and it is consistent with the previous study.

  12. Precise nuclear physics for the sun

    International Nuclear Information System (INIS)

    Bemmerer, Daniel

    2012-01-01

    For many centuries, the study of the Sun has been an important testbed for understanding stars that are further away. One of the first astronomical observations Galileo Galilei made in 1612 with the newly invented telescope concerned the sunspots, and in 1814, Joseph von Fraunhofer employed his new spectroscope to discover the absorption lines in the solar spectrum that are now named after him. Even though more refined and new modes of observation are now available than in the days of Galileo and Fraunhofer, the study of the Sun is still high on the agenda of contemporary science, due to three guiding interests. The first is connected to the ages-old human striving to understand the structure of the larger world surrounding us. Modern telescopes, some of them even based outside the Earth's atmosphere in space, have succeeded in observing astronomical objects that are billions of light-years away. However, for practical reasons precision data that are important for understanding stars can still only be gained from the Sun. In a sense, the observations of far-away astronomical objects thus call for a more precise study of the closeby, of the Sun, for their interpretation. The second interest stems from the human desire to understand the essence of the world, in particular the elementary particles of which it consists. Large accelerators have been constructed to produce and collide these particles. However, man-made machines can never be as luminous as the Sun when it comes to producing particles. Solar neutrinos have thus served not only as an astronomical tool to understand the Sun's inner workings, but their behavior on the way from the Sun to the Earth is also being studied with the aim to understand their nature and interactions. The third interest is strictly connected to life on Earth. A multitude of research has shown that even relatively slight changes in the Earth's climate may strongly affect the living conditions in a number of densely populated areas

  13. Precise nuclear physics for the sun

    Energy Technology Data Exchange (ETDEWEB)

    Bemmerer, Daniel

    2012-07-01

    For many centuries, the study of the Sun has been an important testbed for understanding stars that are further away. One of the first astronomical observations Galileo Galilei made in 1612 with the newly invented telescope concerned the sunspots, and in 1814, Joseph von Fraunhofer employed his new spectroscope to discover the absorption lines in the solar spectrum that are now named after him. Even though more refined and new modes of observation are now available than in the days of Galileo and Fraunhofer, the study of the Sun is still high on the agenda of contemporary science, due to three guiding interests. The first is connected to the ages-old human striving to understand the structure of the larger world surrounding us. Modern telescopes, some of them even based outside the Earth's atmosphere in space, have succeeded in observing astronomical objects that are billions of light-years away. However, for practical reasons precision data that are important for understanding stars can still only be gained from the Sun. In a sense, the observations of far-away astronomical objects thus call for a more precise study of the closeby, of the Sun, for their interpretation. The second interest stems from the human desire to understand the essence of the world, in particular the elementary particles of which it consists. Large accelerators have been constructed to produce and collide these particles. However, man-made machines can never be as luminous as the Sun when it comes to producing particles. Solar neutrinos have thus served not only as an astronomical tool to understand the Sun's inner workings, but their behavior on the way from the Sun to the Earth is also being studied with the aim to understand their nature and interactions. The third interest is strictly connected to life on Earth. A multitude of research has shown that even relatively slight changes in the Earth's climate may strongly affect the living conditions in a number of densely

  14. Precision Light Flavor Physics from Lattice QCD

    Science.gov (United States)

    Murphy, David

    In this thesis we present three distinct contributions to the study of light flavor physics using the techniques of lattice QCD. These results are arranged into four self-contained papers. The first two papers concern global fits of the quark mass, lattice spacing, and finite volume dependence of the pseudoscalar meson masses and decay constants, computed in a series of lattice QCD simulations, to partially quenched SU(2) and SU(3) chiral perturbation theory (chiPT). These fits determine a subset of the low energy constants of chiral perturbation theory -- in some cases with increased precision, and in other cases for the first time -- which, once determined, can be used to compute other observables and amplitudes in chiPT. We also use our formalism to self-consistently probe the behavior of the (asymptotic) chiral expansion as a function of the quark masses by repeating the fits with different subsets of the data. The third paper concerns the first lattice QCD calculation of the semileptonic K0 → pi-l +nul ( Kl3) form factor at vanishing momentum transfer, f+Kpi(0), with physical mass domain wall quarks. The value of this form factor can be combined with a Standard Model analysis of the experimentally measured K0 → pi -l+nu l decay rate to extract a precise value of the Cabibbo-Kobayashi-Maskawa (CKM) matrix element Vus, and to test unitarity of the CKM matrix. We also discuss lattice calculations of the pion and kaon decay constants, which can be used to extract Vud through an analogous Standard Model analysis of experimental constraints on leptonic pion and kaon decays. The final paper explores the recently proposed exact one flavor algorithm (EOFA). This algorithm has been shown to drastically reduce the memory footprint required to simulate single quark flavors on the lattice relative to the widely used rational hybrid Monte Carlo (RHMC) algorithm, while also offering modest O(20%) speed-ups. We independently derive the exact one flavor action, explore its

  15. Precision and Accuracy in PDV and VISAR

    Energy Technology Data Exchange (ETDEWEB)

    Ambrose, W. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-08-22

    This is a technical report discussing our current level of understanding of a wide and varying distribution of uncertainties in velocity results from Photonic Doppler Velocimetry in its application to gas gun experiments. Using propagation of errors methods with statistical averaging of photon number fluctuation in the detected photocurrent and subsequent addition of electronic recording noise, we learn that the velocity uncertainty in VISAR can be written in closed form. For PDV, the non-linear frequency transform and peak fitting methods employed make propagation of errors estimates notoriously more difficult to write down in closed form expect in the limit of constant velocity and low time resolution (large analysis-window width). An alternative method of error propagation in PDV is to use Monte Carlo methods with a simulation of the time domain signal based on results from the spectral domain. A key problem for Monte Carlo estimation for an experiment is a correct estimate of that portion of the time-domain noise associated with the peak-fitting region-of-interesting in the spectral domain. Using short-time Fourier transformation spectral analysis and working with the phase dependent real and imaginary parts allows removal of amplitude-noise cross terms that invariably show up when working with correlation-based methods or FFT power spectra. Estimation of the noise associated with a given spectral region of interest is then possible. At this level of progress, we learn that Monte Carlo trials with random recording noise and initial (uncontrolled) phase yields velocity uncertainties that are not as large as those observed. In a search for additional noise sources, a speckleinterference modulation contribution with off axis rays was investigated, and was found to add a velocity variation beyond that from the recording noise (due to random interference between off axis rays), but in our experiments the speckle modulation precision was not as important as the

  16. Programming supramolecular biohybrids as precision therapeutics.

    Science.gov (United States)

    Ng, David Yuen Wah; Wu, Yuzhou; Kuan, Seah Ling; Weil, Tanja

    2014-12-16

    CONSPECTUS: Chemical programming of macromolecular structures to instill a set of defined chemical properties designed to behave in a sequential and precise manner is a characteristic vision for creating next generation nanomaterials. In this context, biopolymers such as proteins and nucleic acids provide an attractive platform for the integration of complex chemical design due to their sequence specificity and geometric definition, which allows accurate translation of chemical functionalities to biological activity. Coupled with the advent of amino acid specific modification techniques, "programmable" areas of a protein chain become exclusively available for any synthetic customization. We envision that chemically reprogrammed hybrid proteins will bridge the vital link to overcome the limitations of synthetic and biological materials, providing a unique strategy for tailoring precision therapeutics. In this Account, we present our work toward the chemical design of protein- derived hybrid polymers and their supramolecular responsiveness, while summarizing their impact and the advancement in biomedicine. Proteins, in their native form, represent the central framework of all biological processes and are an unrivaled class of macromolecular drugs with immense specificity. Nonetheless, the route of administration of protein therapeutics is often vastly different from Nature's biosynthesis. Therefore, it is imperative to chemically reprogram these biopolymers to direct their entry and activity toward the designated target. As a consequence of the innate structural regularity of proteins, we show that supramolecular interactions facilitated by stimulus responsive chemistry can be intricately designed as a powerful tool to customize their functions, stability, activity profiles, and transportation capabilities. From another perspective, a protein in its denatured, unfolded form serves as a monodispersed, biodegradable polymer scaffold decorated with functional side

  17. Precise Orbit Determination of QZS-1

    Science.gov (United States)

    Hugentobler, U.; Steigenberger, P.; Rodriguez-Solano, C.; Hauschild, A.

    2011-12-01

    QZS-1, the first satellite of the Japanese Quasi Zenith Satellite System (QZSS) was launched in September 2010. Transmission of the standard codes started in December 2010 and the satellite was declared healthy in June 2011. Five stations of the COoperative Network for GIOVE Observation (CONGO) were upgraded to provide QZSS tracking capability. These five stations provide the basis for the precise orbit determination (POD) of the QZS-1 spacecraft. The stability and consistency of different orbital arc lengths is analyzed based on orbit fit residuals, day boundary discontinuities, and Satellite Laser Ranging residuals. As QZS-1 simultaneously transmits navigation signals on three frequencies in the L1, L2, and L5 band, different ionosphere-free linear combinations can be formed. The differences of the orbits computed from these different observables (ionosphere-free linear combination of L1/L2 and L1/L5) as well as the stability of the differential code biases estimated within the POD are studied. Finally, results of the attitude determination based on the navigation signal transmission from two different antennas onboard QZS-1 are presented.

  18. Design of precision position adjustable scoop

    International Nuclear Information System (INIS)

    Li Zhili; Zhang Kai; Dong Jinping

    2014-01-01

    In isotopes separation technologies, the centrifuge method has been the most popular technology now. Separation performance of centrifugal machines is greatly influenced by the flow field in the centrifugal machines. And the position of scoops in the centrifuges has a significant influence on the flow field. To obtain a better flow field characteristic and find the best position of scoops in the centrifuges, a position adjustable scoop system was studied. A micro stage and a linear encoder were used in the system to improve the position accuracy of the scoop. Eddy current sensors had been used in a position calibration measurement. The measurement result showed the sensitivity and stability of the position system could meet the performance expectation. But as the driving mean, the steel wire and pulley limit the control precision. On the basis of this scheme, an ultrasonic motor was used as driving mean. Experimental results showed the control accuracy was improved. This scheme laid a foundation to obtain internal flow field parameters of centrifuge and get the optimal feeding tube position. (authors)

  19. Toward precision holography with supersymmetric Wilson loops

    Energy Technology Data Exchange (ETDEWEB)

    Faraggi, Alberto [Instituto de Física, Pontificia Universidad Católica de Chile,Casilla 306, Santiago (Chile); Zayas, Leopoldo A. Pando [The Abdus Salam International Centre for Theoretical Physics,Strada Costiera 11, 34014 Trieste (Italy); Michigan Center for Theoretical Physics, Department of Physics,University of Michigan, Ann Arbor, MI 48109 (United States); Silva, Guillermo A. [Instituto de Física de La Plata - CONICET & Departamento de Física - UNLP,C.C. 67, 1900 La Plata (Argentina); Trancanelli, Diego [Institute of Physics, University of São Paulo,05314-970 São Paulo (Brazil)

    2016-04-11

    We consider certain 1/4 BPS Wilson loop operators in SU(N)N=4 supersymmetric Yang-Mills theory, whose expectation value can be computed exactly via supersymmetric localization. Holographically, these operators are mapped to fundamental strings in AdS{sub 5}×S{sup 5}. The string on-shell action reproduces the large N and large coupling limit of the gauge theory expectation value and, according to the AdS/CFT correspondence, there should also be a precise match between subleading corrections to these limits. We perform a test of such match at next-to-leading order in string theory, by deriving the spectrum of quantum fluctuations around the classical string solution and by computing the corresponding 1-loop effective action. We discuss in detail the supermultiplet structure of the fluctuations. To remove a possible source of ambiguity in the ghost zero mode measure, we compare the 1/4 BPS configuration with the 1/2 BPS one, dual to a circular Wilson loop. We find a discrepancy between the string theory result and the gauge theory prediction, confirming a previous result in the literature. We are able to track the modes from which this discrepancy originates, as well as the modes that by themselves would give the expected result.

  20. Precise GNSS Positioning Using Smart Devices

    Directory of Open Access Journals (Sweden)

    Eugenio Realini

    2017-10-01

    Full Text Available The recent access to GNSS (Global Navigation Satellite System phase observations on smart devices, enabled by Google through its Android operating system, opens the possibility to apply precise positioning techniques using off-the-shelf, mass-market devices. The target of this work is to evaluate whether this is feasible, and which positioning accuracy can be achieved by relative positioning of the smart device with respect to a base station. Positioning of a Google/HTC Nexus 9 tablet was performed by means of batch least-squares adjustment of L1 phase double-differenced observations, using the open source goGPS software, over baselines ranging from approximately 10 m to 8 km, with respect to both physical (geodetic or low-cost and virtual base stations. The same positioning procedure was applied also to a co-located u-blox low-cost receiver, to compare the performance between the receiver and antenna embedded in the Nexus 9 and a standard low-cost single-frequency receiver with external patch antenna. The results demonstrate that with a smart device providing raw GNSS phase observations, like the Nexus 9, it is possible to reach decimeter-level accuracy through rapid-static surveys, without phase ambiguity resolution. It is expected that sub-centimeter accuracy could be achieved, as demonstrated for the u-blox case, if integer phase ambiguities were correctly resolved.

  1. Precision electroweak measurements on the $Z$ resonance

    CERN Document Server

    Schael, S; Brunelière, R; Buskulic, Damir; De Bonis, I; Décamp, D; Ghez, P; Goy, C; Jézéquel, S; Lees, J P; Lucotte, A; Martin, F; Merle, E; Minard, M N; Nief, J Y; Odier, P; Pietrzyk, B; Trocmé, B; Bravo, S; Casado, M P; Chmeissani, M; Comas, P; Crespo, J M; Fernández, E; Fernández-Bosman, M; Garrido, L; Graugès-Pous, E; Juste, A; Martínez, M; Merino, G; Miquel, R; Mir, L M; Orteu, S; Pacheco, A; Park, I C; Perlas, J; Riu, I; Ruiz, H; Sánchez, F; Colaleo, A; Creanza, D; De Filippis, N; De Palma, M; Iaselli, G; Maggi, G; Maggi, M; Nuzzo, S; Ranieri, A; Raso, G; Ruggieri, F; Selvaggi, G; Silvestris, L; Tempesta, P; Tricomi, A; Zito, G; Huang, X; Lin, J; Ouyang, Q; Wang, T; Xie, Y; Xu, R; Xue, S; Zhang, J; Zhang, L; Zhao, W; Abbaneo, D; Bazarko, A; Becker, U; Boix, G; Bird, F; Blucher, E; Bonvicini, B; Bright-Thomas, P; Barklow, T; Cattaneo, M; Cerutti, F; Clerbaux, B; Drevermann, H; Forty, R W; Frank, M; Greening, T C; Hagelberg, R; Halley, A W; Gianotti, F; Girone, M; Hansen, J B; Harvey, J; Jacobsen, R; Hutchcroft, D E; Janot, P; Jost, B; Knobloch, J; Kado, M; Lehraus, Ivan; Lazeyras, Pierre; Maley, P; Mato, P; May, J; Moutoussi, A; Pepé-Altarelli, M; Ranjard, F; Rolandi, Luigi; Schlatter, W D; Schmitt, B; Schneider, O; Tejessy, W; Teubert, F; Tomalin, I R; Tournefier, E; Veenhof, R; Valassi, A; Wiedenmann, W; Wright, A E; Ajaltouni, Ziad J; Badaud, F; Chazelle, G; Deschamps, O; Dessagne, S; Falvard, A; Ferdi, C; Fayolle, D; Gay, P; Guicheney, C; Henrard, P; Jousset, J; Michel, B; Monteil, S; Montret, J C; Pallin, D; Pascolo, J M; Perret, P; Podlyski, F; Bertelsen, H; Fernley, T; Hansen, J D; Hansen, J R; Hansen, P H; Kraan, A C; Lindahl, A; Møllerud, R; Nilsson, B S; Rensch, B; Wäänänen, A; Daskalakis, G; Kyriakis, A; Markou, C; Simopoulou, E; Siotis, I; Vayaki, A; Blondel, A; Bonneaud, G; Brient, J C; Machefert, F; Rougé, A; Rumpf, M; Swynghedauw, M; Tanaka, R; Verderi, M; Videau, H L; Ciulli, V; Focardi, E; Parrini, G; Zachariadou, K; Corden, M; Georgiopoulos, C H; Antonelli, A; Antonelli, M; Bencivenni, G; Bologna, G; Bossi, F; Campana, P; Capon, G; Chiarella, V; Felici, G; Laurelli, P; Mannocchi, G; Murtas, G P; Passalacqua, L; Picchi, P; Colrain, P; ten Have, I; Hughes, I S; Kennedy, J; Knowles, I G; Lynch, J G; Morton, W T; Negus, P; O'Shea, V; Raine, C; Reeves, P; Scarr, J M; Smith, K; Thompson, A S; Turnbull, R M; Wasserbaech, S R; Buchmüller, O L; Cavanaugh, R J; Dhamotharan, S; Geweniger, C; Hanke, P; Hansper, G; Hepp, V; Kluge, E E; Putzer, A; Sommer, J; Tittel, K; Werner, W; Wunsch, M; Beuselinck, R; Binnie, D M; Cameron, W; Davies, G; Dornan, P J; Goodsir, S M; Marinelli, N; Martin, E; Nash, J; Nowell, J; Rutherford, S A; Sedgbeer, J K; Thompson, J C; White, R; Williams, M D; Ghete, V M; Girtler, P; Kneringer, E; Kuhn, D; Rudolph, G; Bouhova-Thacker, E; Bowdery, C K; Buck, P G; Clarke, D P; Ellis, G; Finch, A J; Foster, F; Hughes, G; Jones, R W L; Keemer, N R; Pearson, M R; Robertson, N A; Sloan, T; Smizanska, M; Snow, S W; Williams, M I; van der Aa, O; Delaere, C; Leibenguth, G; Lemaître, V; Bauerdick, L A T; Blumenschein, U; Van Gemmeren, P; Giehl, I; Hölldorfer, F; Jakobs, K; Kasemann, M; Kayser, F; Kleinknecht, K; Müller, A S; Quast, G; Renk, B; Rohne, E; Sander, H G; Schmeling, S; Wachsmuth, H W; Wanke, R; Zeitnitz, C; Ziegler, T; Aubert, Jean-Jacques; Benchouk, C; Bonissent, A; Carr, J; Coyle, P; Curtil, C; Ealet, A; Etienne, F; Fouchez, D; Motsch, F; Payre, P; Rousseau, D; Talby, M; Thulasidas, M; Aleppo, M; Ragusa, F; Büscher, V; David, A; Dietl, H; Ganis, G; Hüttmann, K; Lütjens, G; Mannert, C; Männer, W; Moser, H G; Settles, R; Seywerd, H; Stenzel, H; Villegas, M; Wolf, G; Boucrot, J; Callot, O; Chen, S; Cordier, A; Davier, M; Duflot, L; Grivaz, J F; Heusse, P; Jacholkowska, A; Le Diberder, F R; Lefrançois, J; Mutz, A M; Schune, M H; Serin, L; Veillet, J J; Videau, I; Zerwas, D; Azzurri, P; Bagliesi, G; Bettarini, S; Boccali, T; Bozzi, C; Calderini, G; Dell'Orso, R; Fantechi, R; Ferrante, I; Fidecaro, F; Foà, L; Giammanco, A; Giassi, A; Gregorio, A; Ligabue, F; Lusiani, A; Marrocchesi, P S; Messineo, A; Palla, F; Rizzo, G; Sanguinetti, G; Sciabà, A; Sguazzoni, G; Spagnolo, P; Steinberger, J; Tenchini, R; Vannini, C; Venturi, A; Verdini, P G; Awunor, O; Blair, G A; Cowan, G; García-Bellido, A; Green, M G; Medcalf, T; Strong, J A; Teixeira-Dias, P; Botterill, David R; Clifft, R W; Edgecock, T R; Edwards, M; Haywood, S J; Norton, P R; Ward, J J; Bloch-Devaux, B; Boumediene, D E; Colas, P; Emery, S; Fabbro, B; Kozanecki, Witold; Lançon, E; Lemaire, M C; Locci, E; Pérez, P; Rander, J; Renardy, J F; Roussarie, A; Schuller, J P; Schwindling, J; Tuchming, B; Vallage, B; Black, S N; Dann, J H; Kim, H Y; Konstantinidis, N P; Litke, A M; McNeil, M A; Taylor, G; Booth, C N; Cartwright, S; Combley, F; Hodgson, P N; Lehto, M H; Thompson, L F; Affholderbach, K; Barberio, E; Böhrer, A; Brandt, S; Burkhardt, H; Feigl, E; Grupen, C; Hess, J; Lutters, G; Meinhard, H; Minguet-Rodríguez, J A; Mirabito, L; Misiejuk, A; Neugebauer, E; Ngac, A; Prange, G; Rivera, F; Saraiva, P; Schäfer, U; Sieler, U; Smolik, L; Stephan, F; Trier, H; Apollonio, M; Borean, C; Bosisio, L; Della Marina, R; Giannini, G; Gobbo, B; Musolino, G; Pitis, L; He, H; Kim, H; Pütz, J; Rothberg, J E; Armstrong, S R; Bellantoni, L; Berkelman, K; Cinabro, D; Conway, J S; Cranmer, K; Elmer, P; Feng, Z; Ferguson, D P S; Gao, Y; González, S; Grahl, J; Harton, J L; Hayes, O J; Hu, H; Jin, S; Johnson, R P; Kile, J; McNamara, P A; Nielsen, J; Orejudos, W; Pan, Y B; Saadi, Y; Scott, I J; Sharma, V; Walsh, A M; Walsh, J; Wear, J; Von Wimmersperg-Töller, J H; Wu, J; Wu, S L; Wu, X; Yamartino, J M; Zobernig, G; Dissertori, G; Abdallah, J; Abreu, P; Adam, W; Adye, T; Adzic, P; Ajinenko, I; Albrecht, T; Alderweireld, T; Alekseev, G D; Alemany-Fernandez, R; Allmendinger, T; Allport, P P; Almehed, S; Amaldi, Ugo; Amapane, N; Amato, S; Anashkin, E; Anassontzis, E G; Andersson, P; Andreazza, A; Andringa, S; Anjos, N; Antilogus, P; Apel, W D; Arnoud, Y; Ask, S; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Ballestrero, A; Bambade, P; Barão, F; Barbiellini, G; Barbier, R; Bardin, D; Barker, G; Baroncelli, A; Battaglia, M; Baubillier, M; Becks, K H; Begalli, M; Behrmann, A; Beillière, P; Belokopytov, Yu A; Belous, K S; Ben-Haim, E; Benekos, N; Benvenuti, A C; Bérat, C; Berggren, M; Berntzon, L; Bertini, D; Bertrand, D; Besançon, M; Besson, N; Bianchi, F; Bigi, M; Bilenky, S M; Bizouard, M A; Bloch, D; Blom, M; Bluj, M; Bonesini, M; Bonivento, W; Boonekamp, M; Booth, P S L; Borgland, A W; Borisov, G; Bosio, C; Botner, O; Boudinov, E; Bouquet, B; Bourdarios, C; Bowcock, T J V; Boyko, I; Bozovic, I; Bozzo, M; Bracko, M; Branchini, P; Brenke, T; Brenner, R; Brodet, E; Brückman, P; Brunet, J M; Bugge, L; Buran, T; Burgsmüller, T; Buschbeck, Brigitte; Buschmann, P; Cabrera, S; Caccia, M; Calvi, M; Camacho-Rozas, A J; Camporesi, T; Canale, V; Canepa, M; Carena, F; Carroll, L; Caso, C; Castillo-Gimenez, M V; Castro, N; Cattai, A; Cavallo, F; Chabaud, V; Chapkin, M; Charpentier, P; Chaussard, L; Checchia, P; Chelkov, G A; Chen, M; Chierici, R; Shlyapnikov, P; Chochula, P; Chorowicz, V; Chudoba, J; Chung, S U; Cieslik, K; Collins, P; Colomer, M; Contri, R; Cortina, E; Cosme, G; Cossutti, F; Costa, M J; Cowell, J H; Crawley, H B; Crennell, D J; Crépé, S; Crosetti, G; Cuevas-Maestro, J; Czellar, S; D'Hondt, J; D'Almagne, B; Dalmau, J; Damgaard, G; Davenport, M; Da Silva, T; Da Silva, W; Deghorain, A; Della Ricca, G; Delpierre, P A; Demaria, N; De Angelis, A; de Boer, Wim; De Brabandere, S; De Clercq, C; De Lotto, B; De Maria, N; De Min, A; De Paula, L; Dijkstra, H; Di Ciaccio, L; Di Diodato, A; Di Simone, A; Djannati, A; Dolbeau, J; Doroba, K; Dracos, M; Drees, J; Drees, K A; Dris, M; Duperrin, A; Durand, J D; Ehret, R; Eigen, G; Ekelöf, T J C; Ekspong, G; Ellert, M; Elsing, M; Engel, J P; Erzen, B; Espirito-Santo, M C; Falk, E; Fanourakis, G K; Fassouliotis, D; Fayot, J; Feindt, M; Fenyuk, A; Fernández, J; Ferrari, P; Ferrer, A; 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Rooke, A M; Ros, E; Rosati, S; Roscoe, K; Rossberg, S; Rossi, A M; Rosvick, M; Routenburg, P; Rozen, Y; Runge, K; Runólfsson, O; Ruppel, U; Rust, D R; Rylko, R; Sachs, K; Saeki, T; Sahr, O; Sanghera, S; Sarkisyan-Grinbaum, E; Sasaki, M; Sbarra, C; Schaile, A D; Schaile, O; Schappert, W; Scharf, F; Scharff-Hansen, P; Schenk, P; Schieck, J; von der Schmitt, H; Schmitt, S; Schörner-Sadenius, T; Schreiber, S; Schröder, M; Schütz, P; Schultz-Coulon, H C; Schulz, M; Schumacher, M; Schwarz, J; Schwick, C; Scott, W G; Settles, M; Seuster, R; Shears, T G; Shen, B C; Shepherd-Themistocleous, C H; Sherwood, P; Shypit, R; Simon, A; Singh, P; Siroli, G P; Sittler, A; Skillman, A; Skuja, A; Smith, A M; Smith, T J; Snow, G A; Sobie, R J; Söldner-Rembold, S; Spagnolo, S; Spanó, F; Springer, R W; Sproston, M; Starks, M; Steiert, M; Stephens, K; Steuerer, J; Stier, H E; Stockhausen, B; Stoll, K; Ströhmer, R; Strom, D; Strumia, F; Stumpf, L; Surrow, B; Szymanski, P; Tafirout, R; Takeda, H; Takeshita, T; Talbot, S D; Tanaka, S; Taras, P; Tarem, S; Tasevsky, M; Taylor, R J; Tecchio, M; Tesch, N; Teuscher, R; Thackray, N J; Thiergen, M; Thomson, M A; Von Törne, E; Towers, S; Toya, D; Trócsányi, Z L; Tran, P; Trefzger, T; Tresilian, N J; Trigger, I; Tscheulin, M; Tsukamoto, T; Tsur, E; Turcot, A S; Turner-Watson, M F; Tysarczyk-Niemeyer, G; Ueda, I; Ujvári, B; Utzat, P; Vachon, B; Van den Plas, D; Van Kooten, R; VanDalen, G J; Vannerem, P; Vasseur, G; Vertesi, R; Verzocchi, M; Vikas, P; Vincter, M G; Virtue, C J; Vokurka, E H; Vollmer, C F; Voss, H; Vossebeld, Joost Herman; Wäckerle, F; Wagner, A; Wagner, D L; Wahl, C; Walker, J P; Waller, D; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Weber, P; Weisz, S; Wells, P S; Wengler, T; Wermes, N; Wetterling, D; Weymann, M; Whalley, M A; White, J S; Wilkens, B; Wilson, J A; Wilson, G W; Wingerter, Isabelle; Winterer, V H; Wood, N C; Wotton, S; Wyatt, T R; Yaari, R; Yamashita, S; Yang, Y; Yeaman, A; Yekutieli, G; Yurko, M; Zacek, V; Zacharov, I E; Zer-Zion, D; Zeuner, W; Zivkovic, L; Zorn, G T; Abe, Kenji; Abe, Koya; Abe, T; Abt, I; Acton, P D; Adam, I; Agnew, G; Akagi, T; Akimoto, H; Allen, N J; Ash, W W; Aston, D; Bacchetta, N; Baird, K G; Baltay, C; Band, H R; Barakat, M B; Baranko, G J; Bardon, O; Barklow, T L; Bashindzhagian, G L; Bauer, J M; Bazarko, A O; Bean, A; Bellodi, G; Ben-David, R; Berger, R; Bienz, T; Bilei, G M; Bisello, D; Blaylock, G; Bogart, J R; Bolen, B; Bolton, T; Bower, G R; Brau, J E; Breidenbach, M; Bugg, W M; Burke, D; Burnett, T H; Burrows, P N; Busza, W; Calcaterra, A; Caldwell, D O; Camanzi, B; Carpinelli, M; Cassell, R; Castaldi, R; Castro, A; Cavalli-Sforza, M; Chadwick, George B; Chou, A; Church, E; Claus, R; Cohn, H O; Coller, J A; Convery, M R; Cook, V; Cotton, R; Cowan, R F; Coyne, D G; Crawford, G; de Oliveira, A; Damerell, C J S; Daoudi, M; Dasu, S; De Groot, N; De Sangro, R; De Simone, P; De Simone, S; Dervan, P J; Dima, M; Dong, D N; Doser, Michael; Du, P Y C; Dubois, R; Duboscq, J E; Eisenstein, B I; Elia, R; Erdos, E; Erofeeva, I; Eschenburg, V; Etzion, E; Fahey, S; Falciai, D; Fan, C; Fernández, J P; Fero, M J; Flood, K; Frey, R; Friedman, Jerome Isaac; Furuno, K; Garwin, E L; Gillman, T; Gladding, G; Hallewell, G D; Hart, E L; Hasegawa, Y; Hasuko, K; Hedges, S; Hertzbach, S S; Hildreth, M D; Hitlin, D G; Honma, A; Huber, J S; Huffer, M E; Hughes, E W; Huynh, X; Hwang, H; Iwasaki, M; Iwasaki, Y; Izen, J M; Jackson, D J; Jacques, P; Jaros, J A; Jiang, Z Y; Johnson, A S; Johnson, J R; Johnson, R A; Junk, T R; Kajikawa, R; Kalelkar, M; Kamyshkov, Yu A; Kang, H J; Karliner, I; Kawahara, H; Kelsey, M H; Kendall, H W; Kim, Y D; King, M; King, R; Kofler, R R; Krishna, N M; Kwon, Y; Labs, J F; Kroeger, R S; Langston, M; Lath, A; Lauber, J A; Leith, D W G S; Lia, V; Lin, C; Liu, M X; Loreti, M; Lu, A; Lynch, H L; Ma, J; Mancinelli, G; Manly, S; Mantovani, G C; Markiewicz, T W; Maruyama, T; Masuda, H; Mazzucato, E; McGowan, J F; McKemey, A K; Meadows, B T; Messner, R; Mockett, P M; Moffeit, K C; Moore, T B; Morii, M; Mours, B; Müller, D; Müller, G; Murzin, V; Nagamine, T; Narita, S; Nauenberg, U; Neal, H; Nesom, G; Nussbaum, M; Ohnishi, Y; Oishi, N; Onoprienko, D; Osborne, L S; Panvini, R S; Park, C H; Park, H; Pavel, T J; Peruzzi, I; Pescara, L; Piccolo, M; Piemontese, L; Pieroni, E; Pitts, K T; Plano, R J; Prepost, R; Prescott, C Y; Punkar, G; Quigley, J; Ratcliff, B N; Reeves, K; Reeves, T W; Reidy, J; Reinertsen, P L; Rensing, P E; Rochester, L S; Rowson, P C; Russell, J J; Saxton, O H; Schalk, T; Schindler, R H; Schneekloth, U; Schumm, B A; Schwiening, J; Seiden, A; Sen, S; Serbo, V V; Shaevitz, M H; Shank, J T; Shapiro, G; Sherden, D J; Shmakov, K D; Simopoulos, C; Sinev, N B; Smith, S R; Smy, M B; Snyder, J A; Sokoloff, M D; Stängle, H; Stahl, A; Stamer, P; Steiner, H; Steiner, R; Strauss, M G; Su, D; Suekane, F; Sugiyama, A; Suzuki, A; Suzuki, S; Swartz, M; Szumilo, A; Takahashi, T; Taylor, F E; Thaler, J J; Thom, J; Torrence, E; Trandafir, A I; Turk, J D; Usher, T; Vavra, J; Vella, E; Venuti, J P; Verdier, R; Wagner, S R; Waite, A P; Walston, S; Wang, J; Watts, S J; Weidemann, A W; Weiss, E R; Whitaker, J S; White, S L; Wickens, F J; Williams, D A; Williams, D C; Williams, S H; Willocq, S; Wilson, R J; Wisniewski, W J; Wittlin, J L; Woods, M; Word, G B; Wright, T R; Wyss, J; Yamamoto, R K; Yang, X Q; Yashima, J; Yellin, S J; Young, C C; Yuta, H; Zapalac, G; Zdarko, R W; Zeitlin, C; Zhou, J

    2006-01-01

    We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $MZ$ and $GZ$, and its couplings to fermions, for example the $ ho$ parameter and the effective electroweak mixing angle for leptons, are precisely measured: egin{eqnarray*} MZ & = & 91.1875 pm 0.0021~GeV \\ GZ & = & 2.4952 pm 0.0023~GeV \\ ho_ell & = & 1.0050 pm 0.0010 \\ swsqeffl & =& 0.23153 pm 0.00016 ,. end{eqnarray*} The number of light neutrino species is determined to be $2.9840pm0.0082$, in agreement with the three observed generations of fundamental fermions. The results are compared to the pr...

  2. Precision kaon and hadron physics with KLOE

    International Nuclear Information System (INIS)

    Bossi, F.; De Lucia, E.; Lee-Franzini, J.; Miscetti, S.; Palutan, M.

    2008-01-01

    We describe the KLOE detector at DAΦNE, the Frascati φ, and its physics program. We begin with a brief description of the detector design and operation. Kaon physics is a major topic of investigation with KLOE thanks in part to the unique availability of pure K S , K L , K ± beams at a φ. We have measured all significant branching ratios of all kaon species, the K L and K ± lifetimes and the K → π form factor's t dependence. From the measurements we verify the validity of Cabibbo unitarity and lepton universality. We have studied properties of light scalar and pseudoscalar mesons with unprecedented accuracy. We have measured the e + e - → π + π - cross-section necessary for computing the major part of the hadronic contribution to the muon anomaly. The methods employed in all the above measurements as well as the φ leptonic width, precision mass measurements and searches for forbidden or extremely rare decays of kaons and η-mesons arc described. The impact of our results on flavor and hadron physics to date, as well as an outlook for further improvement in the near future, are discussed

  3. Precise and versatile formula for birefringent filters

    Science.gov (United States)

    Shao, Zhongxing

    1996-07-01

    In an investigation of extraordinary-(E-) ray behavior and the index of refraction for E waves in a uniaxial crystal, a precise and versatile formula for birefringent filters, based on the exact construction of the optical path difference, is set up with neither the approximation Delta n = no - ne less than or equals no (or n e), nor the ambiguity sin( theta )/sin(rw) = ne. The exact construction gives the correct variation of the position and the dimension in each path, yielding the path difference while the filter is tuning. The formula is applicable not only to a filter with its optical axis parallel to the entrance surface (FAPS) but also to a filter with its axis inclined to the surface (FAIS). Also, the formula indicates that a FAIS allows laser wavelengths to be tuned over a wider range than does a FAPS. The origin of the wider range is interpreted to be the greater variation in the index for the FAIS while the filter is tuning. With the help of the formula we design a FAIS for tuning a cw 42.25.Lc.

  4. Cold Antihydrogen for Precise Laser Spectroscopy

    CERN Multimedia

    Gabrielse, G S; Walz, J; Hessels, E A; Tan, J; Oelert, W; George, M C; Grzonka, D J; Kossick, M; Storry, C H; Sefzick, T

    2002-01-01

    %AD-2 %title\\\\ \\\\The Antihydrogen TRAP Collaboration (ATRAP) seeks to do precise laser spectroscopy of antihydrogen. Comparisons of antihydrogen and hydrogen atoms should provide the most stringent test of CPT invariance involving baryons and leptons. ATRAP is an expansion of the TRAP collaboration that developed the techniques to take CERN antiprotons from an energy of 6 MeV (momentum 100 MeV/c) all the way down to thermal equilibrium at 4 K for storage. This storage energy is lower than realized previously by more than ten orders of magnitude. The TRAP techniques include slowing, capturing, electron cooling and stacking of antiprotons. ATRAP and other collaborations will use antiprotons from the Antiproton Decelerator (AD). This new facility makes sense for such experiments because we showed that antiprotons can be accumulated in a trap at much lower expense than was required in the earlier CERN AC-AA-LEAR complex. In the closest approach yet to the production of cold antihydrogen, collaboration members wer...

  5. Precision Electrophile Tagging in Caenorhabditis elegans.

    Science.gov (United States)

    Long, Marcus J C; Urul, Daniel A; Chawla, Shivansh; Lin, Hong-Yu; Zhao, Yi; Haegele, Joseph A; Wang, Yiran; Aye, Yimon

    2018-01-16

    Adduction of an electrophile to privileged sensor proteins and the resulting phenotypically dominant responses are increasingly appreciated as being essential for metazoan health. Functional similarities between the biological electrophiles and electrophilic pharmacophores commonly found in covalent drugs further fortify the translational relevance of these small-molecule signals. Genetically encodable or small-molecule-based fluorescent reporters and redox proteomics have revolutionized the observation and profiling of cellular redox states and electrophile-sensor proteins, respectively. However, precision mapping between specific redox-modified targets and specific responses has only recently begun to be addressed, and systems tractable to both genetic manipulation and on-target redox signaling in vivo remain largely limited. Here we engineer transgenic Caenorhabditis elegans expressing functional HaloTagged fusion proteins and use this system to develop a generalizable light-controlled approach to tagging a prototypical electrophile-sensor protein with native electrophiles in vivo. The method circumvents issues associated with low uptake/distribution and toxicity/promiscuity. Given the validated success of C. elegans in aging studies, this optimized platform offers a new lens with which to scrutinize how on-target electrophile signaling influences redox-dependent life span regulation.

  6. Precision neutrino experiments vs the Littlest Seesaw

    Energy Technology Data Exchange (ETDEWEB)

    Ballett, Peter [Institute for Particle Physics Phenomenology,Department of Physics, Durham University,South Road, Durham DH1 3LE (United Kingdom); King, Stephen F. [School of Physics and Astronomy, University of Southampton,SO17 1BJ Southampton (United Kingdom); Pascoli, Silvia [Institute for Particle Physics Phenomenology,Department of Physics, Durham University,South Road, Durham DH1 3LE (United Kingdom); Prouse, Nick W. [School of Physics and Astronomy, University of Southampton,SO17 1BJ Southampton (United Kingdom); Particle Physics Research Centre, School of Physics and Astronomy,Queen Mary University of London,Mile End Road, London E1 4NS (United Kingdom); Wang, TseChun [Institute for Particle Physics Phenomenology,Department of Physics, Durham University,South Road, Durham DH1 3LE (United Kingdom)

    2017-03-21

    We study to what extent upcoming precision neutrino oscillation experiments will be able to exclude one of the most predictive models of neutrino mass and mixing: the Littlest Seesaw. We show that this model provides a good fit to current data, predicting eight observables from two input parameters, and provide new assessments of its predictions and their correlations. We then assess the ability to exclude this model using simulations of upcoming neutrino oscillation experiments including the medium-distance reactor experiments JUNO and RENO-50 and the long-baseline accelerator experiments DUNE and T2HK. We find that an accurate determination of the currently least well measured parameters, namely the atmospheric and solar angles and the CP phase δ, provide crucial independent tests of the model. For θ{sub 13} and the two mass-squared differences, however, the model’s exclusion requires a combination of measurements coming from a varied experimental programme. Our results show that the synergy and complementarity of future experiments will play a vital role in efficiently discriminating between predictive models of neutrino flavour, and hence, towards advancing our understanding of neutrino oscillations in the context of the flavour puzzle of the Standard Model.

  7. Precision laser spectroscopy of highly charged ions

    International Nuclear Information System (INIS)

    Kuehl, T.; Borneis, S.; Becker, S.; Dax, A.; Engel, T.; Grieser, R.; Huber, G.; Klaft, I.; Klepper, O.; Kohl, A.; Marx, D.; Meier, K.; Neumann, R.; Schmitt, F.; Seelig, P.; Voelker, L.

    1996-01-01

    Recently, intense beams of highly charged ions have become available at heavy ion cooler rings. The obstacle for producing these highly interesting candidates is the large binding energy of K-shell electrons in heavy systems in excess of 100 keV. One way to remove these electrons is to strip them off by passing the ion through material. In the cooler ring, the ions are cooled to a well defined velocity. At the SIS/ESR complex it is possible to produce, store, and cool highly charged ions up to bare uranium with intensities exceeding 10 8 atoms in the ring. This opens the door for precision laser spectroscopy of hydrogenlike-heavy ions, e.g. 209 Bi 82+ , and allows to examine the interaction of the single electron with the large fields of the heavy nucleus, exceeding any artificially produced electric and magnetic fields by orders of magnitude. In the electron cooler the interaction of electrons and highly charged ions otherwise only present in the hottest plasmas can be studied. (orig.)

  8. Precision measurement of $D$ meson mass differences

    CERN Document Server

    INSPIRE-00258707; Abellan Beteta, C; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amerio, S; Amhis, Y; Anderlini, L; Anderson, J; Andreassen, R; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Baesso, C; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bauer, Th; Bay, A; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Burducea, I; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carranza-Mejia, H; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chen, P; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Couturier, B; Cowan, G A; Craik, D C; Cunliffe, S; Currie, R; D'Ambrosio, C; David, P; David, P N Y; Davis, A; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Dogaru, M; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Elsby, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Furfaro, E; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garofoli, J; Garosi, P; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hampson, T; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Hill, D; Hoballah, M; Hombach, C; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Hussain, N; Hutchcroft, D; Hynds, D; Iakovenko, V; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jans, E; Jaton, P; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kochebina, O; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Li Gioi, L; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; Lohn, S; Longstaff, I; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Lucchesi, D; Luisier, J; Luo, H; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Manca, G; Mancinelli, G; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Martins Tostes, D; Massafferri, A; Matev, R; Mathe, Z; Matteuzzi, C; Maurice, E; Mazurov, A; McCarthy, J; McNab, A; McNulty, R; Meadows, B; Meier, F; Meissner, M; Merk, M; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Morello, M J; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen, T D; Nguyen-Mau, C; Nicol, M; Niess, V; Niet, R; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Oyanguren, A; Pal, B K; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petridis, K; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pietrzyk, B; Pilař, T; Pinci, D; Playfer, S; Plo Casasus, M; Polci, F; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Punzi, G; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Rauschmayr, N; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Rives Molina, V; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodriguez Perez, P; Roiser, S; Romanovsky, V; Romero Vidal, A; Rouvinet, J; Ruf, T; Ruffini, F; Ruiz, H; Ruiz Valls, P; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sanmartin Sedes, B; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Smith, M; Sokoloff, M D; Soler, F J P; Soomro, F; Souza, D; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Syropoulos, V; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teklishyn, M; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Tonelli, D; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tresch, M; Tsaregorodtsev, A; Tsopelas, P; Tuning, N; Ubeda Garcia, M; Ukleja, A; Urner, D; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Veneziano, G; Vesterinen, M; Viaud, B; Vieira, D; Vilasis-Cardona, X; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voß, C; Voss, H; Waldi, R; Wallace, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wicht, J; Wiechczynski, J; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Wotton, S A; Wright, S; Wu, S; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yuan, X; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhokhov, A; Zhong, L; Zvyagin, A

    2013-01-01

    Using three- and four-body decays of $D$ mesons produced in semileptonic $b$-hadron decays, precision measurements of $D$ meson mass differences are made together with a measurement of the $D^{0}$ mass. The measurements are based on a dataset corresponding to an integrated luminosity of 1.0 fb$^{-1}$ collected in $pp$ collisions at 7~TeV. Using the decay $D^0 \\rightarrow K^{+} K^{-} K^{-} \\pi^{+}$, the $D^0$ mass is measured to be \\begin{alignat*}{3} M(D^0) \\phantom{ghd} &=&~1864.75 \\pm 0.15 \\,({\\rm stat}) \\pm 0.11 \\,({\\rm syst}) \\, \\textrm{MeV}/c^2. \\end{alignat*} The mass differences \\begin{alignat*}{3} M(D^{+}) - M(D^{0}) &=& 4.76 \\pm 0.12 \\,({\\rm stat}) \\pm 0.07 \\,({\\rm syst}) \\, \\textrm{MeV}/c^2, \\\\ M(D^{+}_s) - M(D^{+}) &=& \\phantom{00}98.68 \\pm 0.03 \\,({\\rm stat}) \\pm 0.04 \\,({\\rm syst}) \\, \\textrm{MeV}/c^2 \\end{alignat*} are measured using the $D^0 \\rightarrow K^{+} K^{-} \\pi^{+} \\pi^{-}$ and $D^{+}_{(s)} \\rightarrow K^{+}K^{-} \\pi^{+}$ modes.

  9. Precision segmented reflectors for space applications

    Science.gov (United States)

    Lehman, David H.; Pawlik, Eugene V.; Meinel, Aden B.; Fichter, W. B.

    1990-08-01

    A project to develop precision segmented reflectors (PSRs) which operate at submillimeter wavelengths is described. The development of a light efficient means for the construction of large-aperture segmented reflecting space-based telescopes is the primary aim of the project. The 20-m Large Deployable Reflector (LDR) telescope is being developed for a survey mission, and it will make use of the reflector panels and materials, structures, and figure control being elaborated for the PSR. The surface accuracy of a 0.9-m PSR panel is shown to be 1.74-micron RMS, the goal of 100-micron RMS positioning accuracy has been achieved for a 4-m erectable structure. A voice-coil actuator for the figure control system architecture demonstrated 1-micron panel control accuracy in a 3-axis evaluation. The PSR technology is demonstrated to be of value for several NASA projects involving optical communications and interferometers as well as missions which make use of large-diameter segmented reflectors.

  10. Light pionic atoms perspectives for precision experiments

    International Nuclear Information System (INIS)

    Gotta, D.

    2005-01-01

    During the last decades high-precision spectroscopy of exotic-atom x-rays profited in particular in the case of pions from the increasing number of stopped particles provided by the cyclotron trap at the accelerator facility of the Paul-Scherrer-Institut (PSI) together with modern detector concepts like charge-coupled devices (CCDs) and crystal spectrometers. Presently, priority is given to the study of the strong-interaction effects in the most elementary system - pionic hydrogen. However, the systems with two or more nucleons are as fundamental for the development of a theoretical description of hadronic matter. Furthermore, the de-excitation of exotic atoms involves a variety of atomic processes, which become accessible in detail due to the high resolution achievable with crystal spectrometers, e. g., parallel transitions, line splittings, broadenings and intensity distributions. In addition, first successful attempts for a microscopic description of the atomic cascade are available now, which should be subject to stringent tests both for atoms and molecules. (author)

  11. LHC Power Converters: A Precision Game

    CERN Multimedia

    2001-01-01

    The LHC test-bed, String 2, is close to commissioning and one important element to get a first chance to prove what it can do is the power converter system. In String 2 there are 16 converters, in the full LHC there will be almost 1800. This article takes a look at what is so special about the power converters for the LHC. The 13 000 Amps power converters with the watercooled cables going to the String 2 feedboxes. The LHC's superconducting magnets will be the pinnacle of high technology. But to work, they'll need the help of high-precision power converters to supply them with extremely stable DC current. Perfection will be the name of the game, with an accuracy of just 1-2 parts per million (ppm) required. LEP, for the sake of comparison, could live with 10-20 ppm. The LHC's power converters will be very different from those of LEP or the SPS since the new accelerator's magnets are mostly superconducting. That means that they require much higher currents at a lower voltage since superconductors have no re...

  12. RPCs: the choreography of precise timing

    CERN Document Server

    Boyko, I; Dydak, F; Elagin, A; Gostkin, M; Koreshev, V; Nefedov, Y; Nikolaev, K; Wotschack, J; Zhemchugov, A

    2005-01-01

    We present a comprehensive overview of all steps to be taken in order to achieve precise timing of the HARP RPCs. After briefly recalling the salient features of the RPC mechanics and electronics, we discuss the results from the dedicated calibration scan in a -12 GeV/c beam which gave valuable first information on efficiency and uniformity of response, charge attenuation, the global time slewing correction, effective strip transit time, relative delays between strips of a pad, and intrinsic time resolution. The latter was determined to be ~140 ps which sets the scale for the control of systematic effects, so as not to deteriorate significantly the overall time-of-flight resolution of the RPCs. From physics data, primarily from `neutral' and `charged' hits in RPC overlap regions, further refinements are derived, in particular padring-specific modifications of the global time slewing correction, and manifestations of the `knock-on' and noise' effects. With a view to a bias-free determination of pad-specific t0...

  13. Pharmacometabolomics informs viromics towards precision medicine

    Directory of Open Access Journals (Sweden)

    Aggeliki Balasopoulou

    2016-10-01

    Full Text Available Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio- informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeutics can be only envisaged when interindividual variability in response to/ toxicity of xenobiotics can be interpreted and thus, predicted. We know that such variability is the net outcome of genetics (host and microbiota and environmental factors (diet, lifestyle, polypharmacy, microbiota and for this, tremendous efforts have been made to clarify key-molecules from correlation to causality to clinical significance. Herein, we focus on the host-microbiome interplay and its direct and indirect impact on efficacy and toxicity of xenobiotics and we inevitably wonder about the role of viruses, as the least acknowledged ones. We present the emerging discipline of pharmacometabolomics-informed viromics, in which pre-dose metabotypes can assist modeling and prediction of interindividual response to/ toxicity of xenobiotics. Such features, either alone or in combination with host genetics, can power biomarker discovery so long as the features are variable among patients, stable enough to be of predictive value, and better than pre-existing tools for predicting therapeutic efficacy/ toxicity.

  14. Pharmacogenetics of asthma: toward precision medicine.

    Science.gov (United States)

    Kersten, Elin T G; Koppelman, Gerard H

    2017-01-01

    Although currently available drugs to treat asthma are effective in most patients, a proportion of patients do not respond or experience side-effects; which is partly genetically determined. Pharmacogenetics is the study of how genetic variations influence drug response. In this review, we summarize prior results and recent studies in pharmacogenetics to determine if we can use genetic profiles for personalized treatment of asthma. The field of pharmacogenetics has moved from candidate gene studies in single populations toward genome-wide association studies and meta-analysis of multiple studies. New technologies have been used to enrich results, and an expanding number of genetic loci have been associated with therapeutic responses to asthma drugs. Prospective, genotype-stratified treatment studies have been conducted for β2-agonists, showing attenuated response in children carrying the Arg16 variant in the β2-adrenoreceptor gene. Although there has been much progress, many findings have not been replicated and currently known genetic loci only account for a fraction of variability in drug response. More research is necessary to translate into clinical practice. A polygenic predictive approach integrated in complex networks with other 'omics' technologies could aid to achieve this goal. Finally, to change clinical practice, studies that compare precision medicine with traditional medicine are needed.

  15. Design of Janus Nanoparticles with Atomic Precision

    Science.gov (United States)

    Sun, Qiang; Wang, Qian; Jena, Puru; Kawazoe, Yoshi

    2008-03-01

    Janus nanoparticles, characterized by their anisotropic structure and interactions have added a new dimension to nanoscience because of their potential applications in biomedicine, sensors, catalysis and assembled materials. The technological applications of these nanoparticles, however, have been limited as the current chemical, physical, and biosynthetic methods lack sufficient size and shape selectivity. We report a technique where gold clusters doped with tungsten can serve as a seed that facilitates the natural growth of anisotropic nanostructures whose size and shape can be controlled with atomic precision. Using ab initio simulated annealing and molecular dynamics calculations on AunW (n>12) clusters, we discovered that the W@Au12 cage cluster forms a very stable core with the remaining Au atoms forming patchy structures on its surface. The anisotropic geometry gives rise to anisotropies in vibrational spectra, charge distributions, electronic structures, and reactivity, thus making it useful to have dual functionalities. In particular, the core-patch structure is shown to possess a hydrophilic head and a hydrophobic tail. The W@Au12 clusters can also be used as building blocks of a nano-ring with novel properties.

  16. Precise GNSS Positioning Using Smart Devices.

    Science.gov (United States)

    Realini, Eugenio; Caldera, Stefano; Pertusini, Lisa; Sampietro, Daniele

    2017-10-24

    The recent access to GNSS (Global Navigation Satellite System) phase observations on smart devices, enabled by Google through its Android operating system, opens the possibility to apply precise positioning techniques using off-the-shelf, mass-market devices. The target of this work is to evaluate whether this is feasible, and which positioning accuracy can be achieved by relative positioning of the smart device with respect to a base station. Positioning of a Google/HTC Nexus 9 tablet was performed by means of batch least-squares adjustment of L1 phase double-differenced observations, using the open source goGPS software, over baselines ranging from approximately 10 m to 8 km, with respect to both physical (geodetic or low-cost) and virtual base stations. The same positioning procedure was applied also to a co-located u-blox low-cost receiver, to compare the performance between the receiver and antenna embedded in the Nexus 9 and a standard low-cost single-frequency receiver with external patch antenna. The results demonstrate that with a smart device providing raw GNSS phase observations, like the Nexus 9, it is possible to reach decimeter-level accuracy through rapid-static surveys, without phase ambiguity resolution. It is expected that sub-centimeter accuracy could be achieved, as demonstrated for the u-blox case, if integer phase ambiguities were correctly resolved.

  17. Precision for B-meson matrix elements

    International Nuclear Information System (INIS)

    Guazzini, D.; Sommer, R.; Tantalo, N.

    2007-10-01

    We demonstrate how HQET and the Step Scaling Method for B-physics, pioneered by the Tor Vergata group, can be combined to reach a further improved precision. The observables considered are the mass of the b-quark and the B s -meson decay constant. The demonstration is carried out in quenched lattice QCD. We start from a small volume, where one can use a standard O(a)-improved relativistic action for the b-quark, and compute two step scaling functions which relate the observables to the large volume ones. In all steps we extrapolate to the continuum limit, separately in HQET and in QCD for masses below m b . The physical point m b is then reached by an interpolation of the continuum results in 1/m. The essential, expected and verified, feature is that the step scaling functions have a weak mass-dependence resulting in an easy interpolation to the physical point. With r 0 =0.5 fm and the experimental B s and K masses as input, we find F B s =191(6) MeV and the renormalization group invariant mass M b =6.88(10) GeV, translating into anti m b (anti m b )=4.42(6) GeV in the MS scheme. This approach seems very promising for full QCD. (orig.)

  18. (No) Eternal inflation and precision Higgs physics

    International Nuclear Information System (INIS)

    Arkani-Hamed, Nima; Dubovsky, Sergei; Senatore, Leonardo; Villadoro, Giovanni

    2008-01-01

    Even if nothing but a light Higgs is observed at the LHC, suggesting that the Standard Model is unmodified up to scales far above the weak scale, Higgs physics can yield surprises of fundamental significance for cosmology. As has long been known, the Standard Model vacuum may be metastable for low enough Higgs mass, but a specific value of the decay rate holds special significance: for a very narrow window of parameters, our Universe has not yet decayed but the current inflationary period can not be future eternal. Determining whether we are in this window requires exquisite but achievable experimental precision, with a measurement of the Higgs mass to 0.1 GeV at the LHC, the top mass to 60 MeV at a linear collider, as well as an improved determination of α s by an order of magnitude on the lattice. If the parameters are observed to lie in this special range, particle physics will establish that the future of our Universe is a global big crunch, without harboring pockets of eternal inflation, strongly suggesting that eternal inflation is censored by the fundamental theory. This conclusion could be drawn even more sharply if metastability with the appropriate decay rate is found in the MSSM, where the physics governing the instability can be directly probed at the TeV scale

  19. Are torque values of preadjusted brackets precise?

    Directory of Open Access Journals (Sweden)

    Alessandra Motta Streva

    Full Text Available OBJECTIVE: The aim of the present study was to verify the torque precision of metallic brackets with MBT prescription using the canine brackets as the representative sample of six commercial brands. MATERIAL AND METHODS: Twenty maxillary and 20 mandibular canine brackets of one of the following commercial brands were selected: 3M Unitek, Abzil, American Orthodontics, TP Orthodontics, Morelli and Ortho Organizers. The torque angle, established by reference points and lines, was measured by an operator using an optical microscope coupled to a computer. The values were compared to those established by the MBT prescription. RESULTS: The results showed that for the maxillary canine brackets, only the Morelli torque (-3.33º presented statistically significant difference from the proposed values (-7º. For the mandibular canines, American Orthodontics (-6.34º and Ortho Organizers (-6.25º presented statistically significant differences from the standards (-6º. Comparing the brands, Morelli presented statistically significant differences in comparison with all the other brands for maxillary canine brackets. For the mandibular canine brackets, there was no statistically significant difference between the brands. CONCLUSIONS: There are significant variations in torque values of some of the brackets assessed, which would clinically compromise the buccolingual positioning of the tooth at the end of orthodontic treatment.

  20. Precision half-life measurement of 11C: The most precise mirror transition F t value

    Science.gov (United States)

    Valverde, A. A.; Brodeur, M.; Ahn, T.; Allen, J.; Bardayan, D. W.; Becchetti, F. D.; Blankstein, D.; Brown, G.; Burdette, D. P.; Frentz, B.; Gilardy, G.; Hall, M. R.; King, S.; Kolata, J. J.; Long, J.; Macon, K. T.; Nelson, A.; O'Malley, P. D.; Skulski, M.; Strauss, S. Y.; Vande Kolk, B.

    2018-03-01

    Background: The precise determination of the F t value in T =1 /2 mixed mirror decays is an important avenue for testing the standard model of the electroweak interaction through the determination of Vu d in nuclear β decays. 11C is an interesting case, as its low mass and small QE C value make it particularly sensitive to violations of the conserved vector current hypothesis. The present dominant source of uncertainty in the 11CF t value is the half-life. Purpose: A high-precision measurement of the 11C half-life was performed, and a new world average half-life was calculated. Method: 11C was created by transfer reactions and separated using the TwinSol facility at the Nuclear Science Laboratory at the University of Notre Dame. It was then implanted into a tantalum foil, and β counting was used to determine the half-life. Results: The new half-life, t1 /2=1220.27 (26 ) s, is consistent with the previous values but significantly more precise. A new world average was calculated, t1/2 world=1220.41 (32 ) s, and a new estimate for the Gamow-Teller to Fermi mixing ratio ρ is presented along with standard model correlation parameters. Conclusions: The new 11C world average half-life allows the calculation of a F tmirror value that is now the most precise value for all superallowed mixed mirror transitions. This gives a strong impetus for an experimental determination of ρ , to allow for the determination of Vu d from this decay.

  1. Defining precision: The precision medicine initiative trials NCI-MPACT and NCI-MATCH.

    Science.gov (United States)

    Coyne, Geraldine O'Sullivan; Takebe, Naoko; Chen, Alice P

    "Precision" trials, using rationally incorporated biomarker targets and molecularly selective anticancer agents, have become of great interest to both patients and their physicians. In the endeavor to test the cornerstone premise of precision oncotherapy, that is, determining if modulating a specific molecular aberration in a patient's tumor with a correspondingly specific therapeutic agent improves clinical outcomes, the design of clinical trials with embedded genomic characterization platforms which guide therapy are an increasing challenge. The National Cancer Institute Precision Medicine Initiative is an unprecedented large interdisciplinary collaborative effort to conceptualize and test the feasibility of trials incorporating sequencing platforms and large-scale bioinformatics processing that are not currently uniformly available to patients. National Cancer Institute-Molecular Profiling-based Assignment of Cancer Therapy and National Cancer Institute-Molecular Analysis for Therapy Choice are 2 genomic to phenotypic trials under this National Cancer Institute initiative, where treatment is selected according to predetermined genetic alterations detected using next-generation sequencing technology across a broad range of tumor types. In this article, we discuss the objectives and trial designs that have enabled the public-private partnerships required to complete the scale of both trials, as well as interim trial updates and strategic considerations that have driven data analysis and targeted therapy assignment, with the intent of elucidating further the benefits of this treatment approach for patients. Copyright © 2017. Published by Elsevier Inc.

  2. Implementing and Characterizing Precise Multiqubit Measurements

    Directory of Open Access Journals (Sweden)

    J. Z. Blumoff

    2016-09-01

    Full Text Available There are two general requirements to harness the computational power of quantum mechanics: the ability to manipulate the evolution of an isolated system and the ability to faithfully extract information from it. Quantum error correction and simulation often make a more exacting demand: the ability to perform nondestructive measurements of specific correlations within that system. We realize such measurements by employing a protocol adapted from Nigg and Girvin [Phys. Rev. Lett. 110, 243604 (2013], enabling real-time selection of arbitrary register-wide Pauli operators. Our implementation consists of a simple circuit quantum electrodynamics module of four highly coherent 3D transmon qubits, collectively coupled to a high-Q superconducting microwave cavity. As a demonstration, we enact all seven nontrivial subset-parity measurements on our three-qubit register. For each, we fully characterize the realized measurement by analyzing the detector (observable operators via quantum detector tomography and by analyzing the quantum backaction via conditioned process tomography. No single quantity completely encapsulates the performance of a measurement, and standard figures of merit have not yet emerged. Accordingly, we consider several new fidelity measures for both the detector and the complete measurement process. We measure all of these quantities and report high fidelities, indicating that we are measuring the desired quantities precisely and that the measurements are highly nondemolition. We further show that both results are improved significantly by an additional error-heralding measurement. The analyses we present here form a useful basis for the future characterization and validation of quantum measurements, anticipating the demands of emerging quantum technologies.

  3. Cancer Prevention in the Precision Medicine Era

    Science.gov (United States)

    Dr. Rebbeck’s research focuses on the etiology and prevention of cancer, with an emphasis on cancers with a genetic etiology and those that are associated with disparities in incidence or mortality by race. He has directed multiple large molecular epidemiologic studies and international consortia that have been used to identify and characterize genes involved in cancer etiology, understand the relationship of allelic variation with biochemical or physiological traits, explore interactions of inherited and somatic genomic variation with epidemiological risk factors. His research also focuses on the roles of biological and social factors on prostate cancer disparities and prostate cancer in Africa through the Men of African Descent and Carcinoma of the Prostate (MADCaP) consortium. He has also led a number of consortia that study carriers of BRCA1 or BRCA2 mutations to understand breast, ovarian, and prostate cancer risk and precision prevention interventions that may reduce that risk. In addition to his research activities, Dr. Rebbeck leads a number of initiatives on the Harvard Campus. He serves as Associate Director for Equity and Engagement in the Dana-Farber / Harvard Cancer Center and Co-Director for the Collective Impact Program of Harvard Catalyst. In this role, he prioritizes the cancer research agenda to maximize disease prevention and risk reduction in Massachusetts. He also oversees a team charged with ensuring that this research engages with and positively impacts communities with the greatest disease burden.  As Director of Global Oncology at the Dana Farber Cancer Institute, Dr. Rebbeck oversees formal and informal training and research partnerships between Dana Farber investigators and trainees with international partners.

  4. Interacting dark sector and precision cosmology

    Science.gov (United States)

    Buen-Abad, Manuel A.; Schmaltz, Martin; Lesgourgues, Julien; Brinckmann, Thejs

    2018-01-01

    We consider a recently proposed model in which dark matter interacts with a thermal background of dark radiation. Dark radiation consists of relativistic degrees of freedom which allow larger values of the expansion rate of the universe today to be consistent with CMB data (H0-problem). Scattering between dark matter and radiation suppresses the matter power spectrum at small scales and can explain the apparent discrepancies between ΛCDM predictions of the matter power spectrum and direct measurements of Large Scale Structure LSS (σ8-problem). We go beyond previous work in two ways: 1. we enlarge the parameter space of our previous model and allow for an arbitrary fraction of the dark matter to be interacting and 2. we update the data sets used in our fits, most importantly we include LSS data with full k-dependence to explore the sensitivity of current data to the shape of the matter power spectrum. We find that LSS data prefer models with overall suppressed matter clustering due to dark matter - dark radiation interactions over ΛCDM at 3–4 σ. However recent weak lensing measurements of the power spectrum are not yet precise enough to clearly distinguish two limits of the model with different predicted shapes for the linear matter power spectrum. In two appendices we give a derivation of the coupled dark matter and dark radiation perturbation equations from the Boltzmann equation in order to clarify a confusion in the recent literature, and we derive analytic approximations to the solutions of the perturbation equations in the two physically interesting limits of all dark matter weakly interacting or a small fraction of dark matter strongly interacting.

  5. PRECISION POINTING OF IBEX-Lo OBSERVATIONS

    International Nuclear Information System (INIS)

    Hłond, M.; Bzowski, M.; Möbius, E.; Kucharek, H.; Heirtzler, D.; Schwadron, N. A.; Neill, M. E. O'; Clark, G.; Crew, G. B.; Fuselier, S.; McComas, D. J.

    2012-01-01

    Post-launch boresight of the IBEX-Lo instrument on board the Interstellar Boundary Explorer (IBEX) is determined based on IBEX-Lo Star Sensor observations. Accurate information on the boresight of the neutral gas camera is essential for precise determination of interstellar gas flow parameters. Utilizing spin-phase information from the spacecraft attitude control system (ACS), positions of stars observed by the Star Sensor during two years of IBEX measurements were analyzed and compared with positions obtained from a star catalog. No statistically significant differences were observed beyond those expected from the pre-launch uncertainty in the Star Sensor mounting. Based on the star observations and their positions in the spacecraft reference system, pointing of the IBEX satellite spin axis was determined and compared with the pointing obtained from the ACS. Again, no statistically significant deviations were observed. We conclude that no systematic correction for boresight geometry is needed in the analysis of IBEX-Lo observations to determine neutral interstellar gas flow properties. A stack-up of uncertainties in attitude knowledge shows that the instantaneous IBEX-Lo pointing is determined to within ∼0. 0 1 in both spin angle and elevation using either the Star Sensor or the ACS. Further, the Star Sensor can be used to independently determine the spacecraft spin axis. Thus, Star Sensor data can be used reliably to correct the spin phase when the Star Tracker (used by the ACS) is disabled by bright objects in its field of view. The Star Sensor can also determine the spin axis during most orbits and thus provides redundancy for the Star Tracker.

  6. LIGASURE (PRECISION HAEMORROIDECTOMY AT GOVT. GENERAL HOSPITAL

    Directory of Open Access Journals (Sweden)

    Anand

    2015-09-01

    Full Text Available BACKGROUND : Haemorrhoids is a common problem throughout the world. Many procedures are available for management of grade II and grade III hemorrhoids. The main postoperative complications associated with any of these procedures are pain and bleeding per rectum and pro longed healing time. Liga Surel TM haemorroidectomy was evaluated in this study for post - operative complications and symptomatic relief. METHODS: We analyzed 50 patients of hemorrhoids of grade II, III and IV who underwent Ligasure Precise haemorroidectomy by a classical Milligan - Morgan technique. The outcome factors analyzed were total operative time, blood loss, post - operative pain on visual analogue scale, any other complication and days of hospital stay. RESULTS: Of all the 50 patients, the operative ti me was less than 10 minutes in 27 patients (54% and the blood loss, as was measured by number of soaked gauze pieces only one gauze piece was soaked in 31 patients (62%. The Average Post - operative pain score measured on Visual Analogue Scale (VAS at 12, 24 & 48 hours were 6.54, 4.52 and 3.12 respectively. In all patients postoperative period and follow up was uneventful except for one patient who developed transient flatus incontinence. With physiotherapy and dietary management this problem resolved ther eafter. CONCLUSIONS: Liga Sure Hemarrhoidectomy is a safe, Technically easy and fast modality of treatment for 2 nd , 3 rd & 4 th degree of hemorrhoids whether single or multiple, requiring very less operating ti me, with no major post - operative complications an d early return to day to day activities

  7. Precision medicine for managing chronic diseases.

    Science.gov (United States)

    Śliwczynski, Andrzej; Orlewska, Ewa

    2016-08-18

    Precision medicine (PM) is an important modern paradigm for combining new types of metrics with big medical datasets to create prediction models for prevention, diagnosis, and specific therapy of chronic diseases. The aim of this paper was to differentiate PM from personalized medicine, to show potential benefits of PM for managing chronic diseases, and to define problems with implementation of PM into clinical practice. PM strategies in chronic airway diseases, diabetes, and cardiovascular diseases show that the key to developing PM is the addition of big datasets to the course of individually profiling diseases and patients. Integration of PM into clinical practice requires the reengineering of the health care infrastructure by incorporating necessary tools for clinicians and patients to enable data collection and analysis, interpretation of the results, as well as to facilitate treatment choices based on new understanding of biological pathways. The size of datasets and their large variability pose a considerable technical and statistical challenge. The potential benefits of using PM are as follows: 1) broader possibilities for physicians to use the achievements of genomics, proteomics, metabolomics, and other "omics" disciplines in routine clinical practice; 2) better understanding of the pathogenesis and epidemiology of diseases; 3) a revised approach to prevention, diagnosis, and treatment of chronic diseases; 4) better integration of electronic medical records as well as data from sensors and software applications in an interactive network of knowledge aimed at improving the modelling and testing of therapeutic and preventative strategies, stimulating further research, and spreading information to the general public.

  8. Reliable low precision simulations in land surface models

    Science.gov (United States)

    Dawson, Andrew; Düben, Peter D.; MacLeod, David A.; Palmer, Tim N.

    2017-12-01

    Weather and climate models must continue to increase in both resolution and complexity in order that forecasts become more accurate and reliable. Moving to lower numerical precision may be an essential tool for coping with the demand for ever increasing model complexity in addition to increasing computing resources. However, there have been some concerns in the weather and climate modelling community over the suitability of lower precision for climate models, particularly for representing processes that change very slowly over long time-scales. These processes are difficult to represent using low precision due to time increments being systematically rounded to zero. Idealised simulations are used to demonstrate that a model of deep soil heat diffusion that fails when run in single precision can be modified to work correctly using low precision, by splitting up the model into a small higher precision part and a low precision part. This strategy retains the computational benefits of reduced precision whilst preserving accuracy. This same technique is also applied to a full complexity land surface model, resulting in rounding errors that are significantly smaller than initial condition and parameter uncertainties. Although lower precision will present some problems for the weather and climate modelling community, many of the problems can likely be overcome using a straightforward and physically motivated application of reduced precision.

  9. Five critical elements to ensure the precision medicine.

    Science.gov (United States)

    Chen, Chengshui; He, Mingyan; Zhu, Yichun; Shi, Lin; Wang, Xiangdong

    2015-06-01

    The precision medicine as a new emerging area and therapeutic strategy has occurred and was practiced in the individual and brought unexpected successes, and gained high attentions from professional and social aspects as a new path to improve the treatment and prognosis of patients. There will be a number of new components to appear or be discovered, of which clinical bioinformatics integrates clinical phenotypes and informatics with bioinformatics, computational science, mathematics, and systems biology. In addition to those tools, precision medicine calls more accurate and repeatable methodologies for the identification and validation of gene discovery. Precision medicine will bring more new therapeutic strategies, drug discovery and development, and gene-oriented treatment. There is an urgent need to identify and validate disease-specific, mechanism-based, or epigenetics-dependent biomarkers to monitor precision medicine, and develop "precision" regulations to guard the application of precision medicine.

  10. Role of Imaging in the Era of Precision Medicine.

    Science.gov (United States)

    Giardino, Angela; Gupta, Supriya; Olson, Emmi; Sepulveda, Karla; Lenchik, Leon; Ivanidze, Jana; Rakow-Penner, Rebecca; Patel, Midhir J; Subramaniam, Rathan M; Ganeshan, Dhakshinamoorthy

    2017-05-01

    Precision medicine is an emerging approach for treating medical disorders, which takes into account individual variability in genetic and environmental factors. Preventive or therapeutic interventions can then be directed to those who will benefit most from targeted interventions, thereby maximizing benefits and minimizing costs and complications. Precision medicine is gaining increasing recognition by clinicians, healthcare systems, pharmaceutical companies, patients, and the government. Imaging plays a critical role in precision medicine including screening, early diagnosis, guiding treatment, evaluating response to therapy, and assessing likelihood of disease recurrence. The Association of University Radiologists Radiology Research Alliance Precision Imaging Task Force convened to explore the current and future role of imaging in the era of precision medicine and summarized its finding in this article. We review the increasingly important role of imaging in various oncological and non-oncological disorders. We also highlight the challenges for radiology in the era of precision medicine. Published by Elsevier Inc.

  11. Fluxgate magnetometry for precise mapping of the Earth's field

    DEFF Research Database (Denmark)

    Primdahl, Fritz; Merayo, José M.G.; Brauer, Peter

    2007-01-01

    The requirements for precise global mapping of the Earth's vector magnetic field from a high inclination LEO satellite needs a stable and precise vector magnetometer. Equally important are the measurement of the stellar attitude of the vector sensor and establishment of the calibration by onboard...... comparison to an absolute scalar magnetometer. In addition, the position in orbit and the precise timing relative to the UTC is needed. Finally, the end-to-end system precision also depends on a known and controlled local satellite magnetic field.......The requirements for precise global mapping of the Earth's vector magnetic field from a high inclination LEO satellite needs a stable and precise vector magnetometer. Equally important are the measurement of the stellar attitude of the vector sensor and establishment of the calibration by onboard...

  12. Autonomous execution of the Precision Immobilization Technique

    Science.gov (United States)

    Mascareñas, David D. L.; Stull, Christopher J.; Farrar, Charles R.

    2017-03-01

    Over the course of the last decade great advances have been made in autonomously driving cars. The technology has advanced to the point that driverless car technology is currently being tested on publicly accessed roadways. The introduction of these technologies onto publicly accessed roadways not only raises questions of safety, but also security. Autonomously driving cars are inherently cyber-physical systems and as such will have novel security vulnerabilities that couple both the cyber aspects of the vehicle including the on-board computing and any network data it makes use of, with the physical nature of the vehicle including its sensors, actuators, and the vehicle chassis. Widespread implementation of driverless car technology will require that both the cyber, as well as physical security concerns surrounding these vehicles are addressed. In this work, we specifically developed a control policy to autonomously execute the Precision Immobilization Technique, a.k.a. the PIT maneuver. The PIT maneuver was originally developed by law enforcement to end high-speed vehicular pursuits in a quasi-safe manner. However, there is still a risk of damage/roll-over to both the vehicle executing the PIT maneuver as well as to the vehicle subject to the PIT maneuver. In law enforcement applications, it would be preferable to execute the PIT maneuver using an autonomous vehicle, thus removing the danger to law-enforcement officers. Furthermore, it is entirely possible that unscrupulous individuals could inject code into an autonomously-driving car to use the PIT maneuver to immobilize other vehicles while maintaining anonymity. For these reasons it is useful to know how the PIT maneuver can be implemented on an autonomous car. In this work a simple control policy based on velocity pursuit was developed to autonomously execute the PIT maneuver using only a vision and range measurements that are both commonly collected by contemporary driverless cars. The ability of this

  13. Atomically Precise Metal Nanoclusters for Catalytic Application

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Rongchao [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2016-11-18

    The central goal of this project is to explore the catalytic application of atomically precise gold nanoclusters. By solving the total structures of ligand-protected nanoclusters, we aim to correlate the catalytic properties of metal nanoclusters with their atomic/electronic structures. Such correlation unravel some fundamental aspects of nanocatalysis, such as the nature of particle size effect, origin of catalytic selectivity, particle-support interactions, the identification of catalytically active centers, etc. The well-defined nanocluster catalysts mediate the knowledge gap between single crystal model catalysts and real-world conventional nanocatalysts. These nanoclusters also hold great promise in catalyzing certain types of reactions with extraordinarily high selectivity. These aims are in line with the overall goals of the catalytic science and technology of DOE and advance the BES mission “to support fundamental research to understand, predict, and ultimately control matter and energy at the level of electrons, atoms, and molecules”. Our group has successfully prepared different sized, robust gold nanoclusters protected by thiolates, such as Au25(SR)18, Au28(SR)20, Au38(SR)24, Au99(SR)42, Au144(SR)60, etc. Some of these nanoclusters have been crystallographically characterized through X-ray crystallography. These ultrasmall nanoclusters (< 2 nm diameter) exhibit discrete electronic structures due to quantum size effect, as opposed to quasicontinuous band structure of conventional metal nanoparticles or bulk metals. The available atomic structures (metal core plus surface ligands) of nanoclusters serve as the basis for structure-property correlations. We have investigated the unique catalytic properties of nanoclusters (i.e. not observed in conventional nanogold catalysts) and revealed the structure-selectivity relationships. Highlights of our

  14. precision deburring using NC and robot equipment. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gillespie, L.K.

    1980-05-01

    Deburring precision miniature components is often time consuming and inconsistent. Although robots are available for deburring parts, they are not precise enough for precision miniature parts. Numerical control (NC) machining can provide edge break consistencies to meet requirements such as 76.2-..mu..m maximum edge break (chamfer). Although NC machining has a number of technical limitations which prohibits its use on many geometries, it can be an effective approach to features that are particularly difficult to deburr.

  15. Astrometry and Geostationary Satellites in Venezuela

    Science.gov (United States)

    Lacruz, E.; Abad, C.

    2015-10-01

    We present the current status and the first results of the astrometric project CIDA - ABAE for tracking geo-stationary satellites. This project aims to determine a preliminary orbit for the Venezuelan satellite VENESAT-1, using astrometric positions obtained from an optical telescope. The results presented here are based on observations from the Luepa space tracking ground station in Venezuela, which were processed using astrometric procedures.

  16. Gaia DR2 documentation Chapter 3: Astrometry

    Science.gov (United States)

    Hobbs, D.; Lindegren, L.; Bastian, U.; Klioner, S.; Butkevich, A.; Stephenson, C.; Hernandez, J.; Lammers, U.; Bombrun, A.; Mignard, F.; Altmann, M.; Davidson, M.; de Bruijne, J. H. J.; Fernández-Hernández, J.; Siddiqui, H.; Utrilla Molina, E.

    2018-04-01

    This chapter of the Gaia DR2 documentation describes the models and processing steps used for the astrometric core solution, namely, the Astrometric Global Iterative Solution (AGIS). The inputs to this solution rely heavily on the basic observables (or astrometric elementaries) which have been pre-processed and discussed in Chapter 2, the results of which were published in Fabricius et al. (2016). The models consist of reference systems and time scales; assumed linear stellar motion and relativistic light deflection; in addition to fundamental constants and the transformation of coordinate systems. Higher level inputs such as: planetary and solar system ephemeris; Gaia tracking and orbit information; initial quasar catalogues and BAM data are all needed for the processing described here. The astrometric calibration models are outlined followed by the details processing steps which give AGIS its name. We also present a basic quality assessment and validation of the scientific results (for details, see Lindegren et al. 2018).

  17. Ground-Based Astrometry 2010-2020

    Science.gov (United States)

    2010-01-01

    target lists come from classic work such as Luyten’s (1979), to more recent all-sky surveys such as 2MASS , DENIS, and SDSS. Follow-up narrow angle...revolutionized the way astronomers work by providing huge datasets of astrometric and photometric data. More recently, SDSS, 5 2MASS , and DENIS have

  18. Real-time Astrometry Using Phase Congruency

    Science.gov (United States)

    Lambert, A.; Polo, M.; Tang, Y.

    Phase congruency is a computer vision technique that proves to perform well for determining the tracks of optical objects (Flewelling, AMOS 2014). We report on a real-time implementation of this using an FPGA and CMOS Image Sensor, with on-sky data. The lightweight instrument can provide tracking update signals to the mount of the telescope, as well as determine abnormal objects in the scene.

  19. MITP Workshop on Low-Energy Precision Physics

    CERN Document Server

    2013-01-01

    The scientific program will be focussed on the theory of low-energy precision physics relevant to the MESA and TRIGA initiatives. Topics include searches for TeV-scale physics beyond the Standard Model via ultra-precise measurements of parity-violating electron scattering asymmetries, determinations of neutron decay parameters via precision measurements of its lifetime and decay asymmetries, and searches for EDMs of nucleons, nuclei and atoms. The necessary high-precision theoretical tools to analyse these experiments, which include advanced calculations of radiative corrections, will be explored and developed.

  20. Attaining the Photometric Precision Required by Future Dark Energy Projects

    Energy Technology Data Exchange (ETDEWEB)

    Stubbs, Christopher [Harvard Univ., Cambridge, MA (United States)

    2013-01-21

    This report outlines our progress towards achieving the high-precision astronomical measurements needed to derive improved constraints on the nature of the Dark Energy. Our approach to obtaining higher precision flux measurements has two basic components: 1) determination of the optical transmission of the atmosphere, and 2) mapping out the instrumental photon sensitivity function vs. wavelength, calibrated by referencing the measurements to the known sensitivity curve of a high precision silicon photodiode, and 3) using the self-consistency of the spectrum of stars to achieve precise color calibrations.

  1. Precision Medicine and PET/Computed Tomography: Challenges and Implementation.

    Science.gov (United States)

    Subramaniam, Rathan M

    2017-01-01

    Precision Medicine is about selecting the right therapy for the right patient, at the right time, specific to the molecular targets expressed by disease or tumors, in the context of patient's environment and lifestyle. Some of the challenges for delivery of precision medicine in oncology include biomarkers for patient selection for enrichment-precision diagnostics, mapping out tumor heterogeneity that contributes to therapy failures, and early therapy assessment to identify resistance to therapies. PET/computed tomography offers solutions in these important areas of challenges and facilitates implementation of precision medicine. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. High precision measurements of the luminosity at LEP

    International Nuclear Information System (INIS)

    Pietrzyk, B.

    1994-01-01

    The art of the luminosity measurements at LEP is presented. First generation LEP detectors have measured the absolute luminosity with the precision of 0.3-0.5%. The most precise present detectors have reached the 0.07% precision and the 0.05% is not excluded in future. Center-of-mass energy dependent relative precision of the luminosity detectors and the use of the theoretical cross-section in the LEP experiments are also discussed. (author). 18 refs., 6 figs., 6 tabs

  3. Introduction to precision machine design and error assessment

    CERN Document Server

    Mekid, Samir

    2008-01-01

    While ultra-precision machines are now achieving sub-nanometer accuracy, unique challenges continue to arise due to their tight specifications. Written to meet the growing needs of mechanical engineers and other professionals to understand these specialized design process issues, Introduction to Precision Machine Design and Error Assessment places a particular focus on the errors associated with precision design, machine diagnostics, error modeling, and error compensation. Error Assessment and ControlThe book begins with a brief overview of precision engineering and applications before introdu

  4. High precision target center determination from a point cloud

    Directory of Open Access Journals (Sweden)

    K. Kregar

    2013-10-01

    Full Text Available Many applications of terrestrial laser scanners (TLS require the determination of a specific point from a point cloud. In this paper procedure of high precision planar target center acquisition from point cloud is presented. The process is based on an image matching algorithm but before we can deal with raster image to fit a target on it, we need to properly determine the best fitting plane and project points on it. The main emphasis of this paper is in the precision estimation and propagation through the whole procedure which allows us to obtain precision assessment of final results (target center coordinates. Theoretic precision estimations – obtained through the procedure were rather high so we compared them with the empiric precision estimations obtained as standard deviations of results of 60 independently scanned targets. An χ2-test confirmed that theoretic precisions are overestimated. The problem most probably lies in the overestimated precisions of the plane parameters due to vast redundancy of points. However, empirical precisions also confirmed that the proposed procedure can ensure a submillimeter precision level. The algorithm can automatically detect grossly erroneous results to some extent. It can operate when the incidence angles of a laser beam are as high as 80°, which is desirable property if one is going to use planar targets as tie points in scan registration. The proposed algorithm will also contribute to improve TLS calibration procedures.

  5. Sampling plans in attribute mode with multiple levels of precision

    International Nuclear Information System (INIS)

    Franklin, M.

    1986-01-01

    This paper describes a method for deriving sampling plans for nuclear material inventory verification. The method presented is different from the classical approach which envisages two levels of measurement precision corresponding to NDA and DA. In the classical approach the precisions of the two measurement methods are taken as fixed parameters. The new approach is based on multiple levels of measurement precision. The design of the sampling plan consists of choosing the number of measurement levels, the measurement precision to be used at each level and the sample size to be used at each level

  6. Precise Plan in the analysis of volume precision in SynergyTM conebeam CT image

    International Nuclear Information System (INIS)

    Bai Sen; Xu Qingfeng; Zhong Renming; Jiang Xiaoqin; Jiang Qingfeng; Xu Feng

    2007-01-01

    Objective: A method of checking the volume precision in Synergy TM conebeam CT image. Methods: To scan known phantoms (big, middle, small spheres, cubes and cuniform cavum) at different positions (CBCT centre and departure centre from 5, 8, 10 cm along the accelerator G-T way)with conebeam CT, the phantom volume of reconstructed images were measure. Then to compared measured volume of Synergy TM conebeam CT with fanbeam CT results and nominal values. Results: The middle spheres had 1.5% discrepancy in nominal values and metrical average values at CBCT centre and departure from centre 5, 8 cm along accelerator G-T way. The small spheres showed 8.1%, with 0.8 % of the big cube and 2.9% of small cube, in nominal values and metrical average values at CBCT centre and departure from centre 5, 8, 10 cm along the accelerator G-T way. Conclusion: In valid scan range of Synergy TM conebeam CT, reconstructed precision is independent of the distance deviation from the center. (authors)

  7. Data Collection Satellite Application in Precision Agriculture

    Science.gov (United States)

    Durào, O.

    2002-01-01

    's over Brazilian territory. There were 25 platforms when SCD-1 was launched. However this number is growing rapidly to 400 platforms, at first for measurements of water reservoir levels as well as other hydrology applications (The Brazilian Electricity Regulatory Agency - ANEEL is the customer), and for many other different applications such as meteorology, oceanography, environmental monitoring sciences, and people and animal tracking. The clear feeling is that users are discovering a satellite system whose benefits were not previously well understood when launched and being able to propose and come up with different and useful applications. A new field in the country that has a great potential to benefit from this system is agriculture. Per se, this is a very important sector of the Brazilian economy and its international trade. Combining it with space technology may justify the investment of new and low cost dedicated satellites. This paper describes a new proposal for use of the SCD-1,2,CBERS-1 satellite system for precision agriculture. New PCD's would be developed for measurements of chemical content of the soil, such as, for example, Nitrogen and others, beyond humidity and solar incidence. This can lead to a more efficient fertilization, harvesting and even the spray of chemical defensives, with the consequence of environment protection. The PCD's ground network so established, along with the information network already available, combined with the space segment of such a system may, as previously said, be able to justify the investment in low cost satellites with this sole purpose.

  8. Vermeer's The Little Street: a precise location

    Directory of Open Access Journals (Sweden)

    Frans Grijzenhout

    2018-03-01

    Full Text Available In the autumn of 2015, Frans Grijzenhout published his sensational findings regarding the likely location of Johannes Vermeer’s ‘little street’ (The Little Street. After consulting a variety of sources, including the ‘The Ledger of Dredging of the Canals in the Town of Delft’ from 1666–1667, he had reached the conclusion that the famous painting by Vermeer must have been based on the houses and two intervening passageways that in Vermeer’s day stood on Vlamingstraat, an unassuming canal in the eastern part of Delft, where numbers 40 and 42 stand today. He had also ascertained that one of Vermeer’s aunts, Ariaentgen Claes van der Minne, was the occupant of 42 Vlamingstraat at that time. Several authors have since produced material indicating that Vermeer painted the right-hand house in Little Street ‘from life’: the house was, it now appears, observed and reproduced in meticulous detail. The same can now be confirmed for other aspects, such as the colour used for the painted shutters and the recesses for wind hooks in the sill of the window of the righthand house. Philip Steadman has rightly pointed to an apparent discrepancy of four feet (c. 1.25 m. between the details in the aforementioned ‘Ledger of the Dredging of the Canals in the Town of Delft’ and the actual spatial situation at 40 Vlamingstraat. This difference can be traced back to the fact that the gateway provided access to both front and back houses. Accordingly, the owners of both front and back houses would have been taxed on the width (four feet of the passageway. Given what we know about the meticulous precision with which the Ledger was compiled in the case of 42 Vlamingstraat, it is inconceivable that the authors of the register for number 40 should have made a mistake. A spatial rendering based on an earlier perspective study of The Little Street, corresponds surprisingly well, and in some respects in detail, with the cadastral and other information we

  9. Precision Health Economics and Outcomes Research to Support Precision Medicine: Big Data Meets Patient Heterogeneity on the Road to Value

    Directory of Open Access Journals (Sweden)

    Yixi Chen

    2016-11-01

    Full Text Available The “big data” era represents an exciting opportunity to utilize powerful new sources of information to reduce clinical and health economic uncertainty on an individual patient level. In turn, health economic outcomes research (HEOR practices will need to evolve to accommodate individual patient–level HEOR analyses. We propose the concept of “precision HEOR”, which utilizes a combination of costs and outcomes derived from big data to inform healthcare decision-making that is tailored to highly specific patient clusters or individuals. To explore this concept, we discuss the current and future roles of HEOR in health sector decision-making, big data and predictive analytics, and several key HEOR contexts in which big data and predictive analytics might transform traditional HEOR into precision HEOR. The guidance document addresses issues related to the transition from traditional to precision HEOR practices, the evaluation of patient similarity analysis and its appropriateness for precision HEOR analysis, and future challenges to precision HEOR adoption. Precision HEOR should make precision medicine more realizable by aiding and adapting healthcare resource allocation. The combined hopes for precision medicine and precision HEOR are that individual patients receive the best possible medical care while overall healthcare costs remain manageable or become more cost-efficient.

  10. Predicting Document Retrieval System Performance: An Expected Precision Measure.

    Science.gov (United States)

    Losee, Robert M., Jr.

    1987-01-01

    Describes an expected precision (EP) measure designed to predict document retrieval performance. Highlights include decision theoretic models; precision and recall as measures of system performance; EP graphs; relevance feedback; and computing the retrieval status value of a document for two models, the Binary Independent Model and the Two Poisson…

  11. Precision Learning Assessment: An Alternative to Traditional Assessment Techniques.

    Science.gov (United States)

    Caltagirone, Paul J.; Glover, Christopher E.

    1985-01-01

    A continuous and curriculum-based assessment method, Precision Learning Assessment (PLA), which integrates precision teaching and norm-referenced techniques, was applied to a math computation curriculum for 214 third graders. The resulting districtwide learning curves defining average annual progress through the computation curriculum provided…

  12. Precision medicine: In need of guidance and surveillance.

    Science.gov (United States)

    Lin, Jian-Zhen; Long, Jun-Yu; Wang, An-Qiang; Zheng, Ying; Zhao, Hai-Tao

    2017-07-28

    Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval. Thus, this medical approach is currently in its infancy; it has promising prospects, but it needs to overcome numbers of problems and deficiencies. It is expected that in addition to conventional symptoms and signs, precision medicine will define disease in terms of the underlying molecular characteristics and other environmental susceptibility factors. Those expectations should be realized by constructing a novel data network, integrating clinical data from individual patients and personal genomic background with existing research on the molecular makeup of diseases. In addition, multi-omics analysis and multi-discipline collaboration will become crucial elements in precision medicine. Precision medicine deserves strong support, and its development demands directed momentum. We propose three kinds of impetus (research, application and collaboration impetus) for such directed momentum toward promoting precision medicine and accelerating its clinical translation and application.

  13. Prognostic and predictive biomarkers in colorectal cancer. Towards precision medicine

    NARCIS (Netherlands)

    Reimers, Marlies Suzanne

    2015-01-01

    The aim of this thesis was to define prognostic and predictive biomarkers in colorectal cancer for improved risk stratification and treatment benefit in the individual patient, with the introduction of precision medicine in the near future as the ultimate goal. By definition, precision medicine is

  14. Problems, challenges and promises: perspectives on precision medicine.

    Science.gov (United States)

    Duffy, David J

    2016-05-01

    The 'precision medicine (systems medicine)' concept promises to achieve a shift to future healthcare systems with a more proactive and predictive approach to medicine, where the emphasis is on disease prevention rather than the treatment of symptoms. The individualization of treatment for each patient will be at the centre of this approach, with all of a patient's medical data being computationally integrated and accessible. Precision medicine is being rapidly embraced by biomedical researchers, pioneering clinicians and scientific funding programmes in both the European Union (EU) and USA. Precision medicine is a key component of both Horizon 2020 (the EU Framework Programme for Research and Innovation) and the White House's Precision Medicine Initiative. Precision medicine promises to revolutionize patient care and treatment decisions. However, the participants in precision medicine are faced with a considerable central challenge. Greater volumes of data from a wider variety of sources are being generated and analysed than ever before; yet, this heterogeneous information must be integrated and incorporated into personalized predictive models, the output of which must be intelligible to non-computationally trained clinicians. Drawing primarily from the field of 'oncology', this article will introduce key concepts and challenges of precision medicine and some of the approaches currently being implemented to overcome these challenges. Finally, this article also covers the criticisms of precision medicine overpromising on its potential to transform patient care. © The Author 2015. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  15. Precision two-photon spectroscopy of alkali elements

    Indian Academy of Sciences (India)

    2014-07-18

    Jul 18, 2014 ... A review of various techniques adopted for measuring absolute frequencies of the atomic transitions and precision measurements of isotope shifts and hyperfine structures (HFS) is presented. Some of the recent works on precision measurements of HFS constants of 6 2 S 1 / 2 level of 39 K and 41 K, 9 2 ...

  16. Design of a kinematic coupling for precision applications

    NARCIS (Netherlands)

    Schouten, C.H.; Rosielle, P.C.J.N.; Schellekens, P.H.J.

    1997-01-01

    To machine a complex precision product, several tools are needed. These tools are placed on a tool turret. A tool must return several times to its original position. To attain a very high repeatability between the upper part and the base of the tool turret mounted on a precision lathe, it is

  17. The study of high precision neutron moisture gauge

    International Nuclear Information System (INIS)

    Liu Shengkang; Bao Guanxiong; Sang Hai; Zhu Yuzhen

    1993-01-01

    The principle, structure and calibration experiment of the high precision neutron moisture gauge (insertion type) are described. The gauge has been appraised. The precision of the measuring moisture of coke is lower than 0.5%, and the range of the measuring moisture is 2%-12%. The economic benefit of the gauge application is good

  18. Estimating maneuvers for precise relative orbit determination using GPS

    Science.gov (United States)

    Allende-Alba, Gerardo; Montenbruck, Oliver; Ardaens, Jean-Sébastien; Wermuth, Martin; Hugentobler, Urs

    2017-01-01

    Precise relative orbit determination is an essential element for the generation of science products from distributed instrumentation of formation flying satellites in low Earth orbit. According to the mission profile, the required formation is typically maintained and/or controlled by executing maneuvers. In order to generate consistent and precise orbit products, a strategy for maneuver handling is mandatory in order to avoid discontinuities or precision degradation before, after and during maneuver execution. Precise orbit determination offers the possibility of maneuver estimation in an adjustment of single-satellite trajectories using GPS measurements. However, a consistent formulation of a precise relative orbit determination scheme requires the implementation of a maneuver estimation strategy which can be used, in addition, to improve the precision of maneuver estimates by drawing upon the use of differential GPS measurements. The present study introduces a method for precise relative orbit determination based on a reduced-dynamic batch processing of differential GPS pseudorange and carrier phase measurements, which includes maneuver estimation as part of the relative orbit adjustment. The proposed method has been validated using flight data from space missions with different rates of maneuvering activity, including the GRACE, TanDEM-X and PRISMA missions. The results show the feasibility of obtaining precise relative orbits without degradation in the vicinity of maneuvers as well as improved maneuver estimates that can be used for better maneuver planning in flight dynamics operations.

  19. Covariate Imbalance and Precision in Measuring Treatment Effects

    Science.gov (United States)

    Liu, Xiaofeng Steven

    2011-01-01

    Covariate adjustment can increase the precision of estimates by removing unexplained variance from the error in randomized experiments, although chance covariate imbalance tends to counteract the improvement in precision. The author develops an easy measure to examine chance covariate imbalance in randomization by standardizing the average…

  20. UAV low-altitude remote sensing for precision weed management

    Science.gov (United States)

    Precision weed management, an application of precision agriculture, accounts for within-field variability of weed infestation and herbicide damage. Unmanned aerial vehicles (UAVs) provide a unique platform for remote sensing of field crops. They are more efficient and flexible than manned agricultur...

  1. PRECISE - pregabalin in addition to usual care: Statistical analysis plan

    NARCIS (Netherlands)

    S. Mathieson (Stephanie); L. Billot (Laurent); C. Maher (Chris); A.J. McLachlan (Andrew J.); J. Latimer (Jane); B.W. Koes (Bart); M.J. Hancock (Mark J.); I. Harris (Ian); R.O. Day (Richard O.); J. Pik (Justin); S. Jan (Stephen); C.-W.C. Lin (Chung-Wei Christine)

    2016-01-01

    textabstractBackground: Sciatica is a severe, disabling condition that lacks high quality evidence for effective treatment strategies. This a priori statistical analysis plan describes the methodology of analysis for the PRECISE study. Methods/design: PRECISE is a prospectively registered, double

  2. Precision templates for gluing wire holding pieces to chamber frames

    International Nuclear Information System (INIS)

    Berdugo, J.; Burgos, C; Cerrada, M.

    1995-01-01

    In the present report we describe the procedure which has been used in order to optimize the precision obtained when positioning forward backward muon chamber sensor wire planes of the L3 experiment at CERN. With templates produced at CIEMAT a precision of about 10 microns. In sizes of the order of 3 meters. has been achieved. (Author) 2 refs

  3. Precision templates for glueing wire holding pieces to chamber frames

    International Nuclear Information System (INIS)

    Berdugo, J.; Burgos, C.; Cerrada, M.

    1995-09-01

    In the present report we describe the procedure which has been used in order to optimize the precision obtained when positioning forward backward muon chamber sensor wire planes of the L3 experiment at CERN. With templates produced at CIEMAT a precision of about 10 microns, in sizes of the order of 3 meters has been achieved

  4. Joint Estimation of Multiple Precision Matrices with Common Structures.

    Science.gov (United States)

    Lee, Wonyul; Liu, Yufeng

    Estimation of inverse covariance matrices, known as precision matrices, is important in various areas of statistical analysis. In this article, we consider estimation of multiple precision matrices sharing some common structures. In this setting, estimating each precision matrix separately can be suboptimal as it ignores potential common structures. This article proposes a new approach to parameterize each precision matrix as a sum of common and unique components and estimate multiple precision matrices in a constrained l 1 minimization framework. We establish both estimation and selection consistency of the proposed estimator in the high dimensional setting. The proposed estimator achieves a faster convergence rate for the common structure in certain cases. Our numerical examples demonstrate that our new estimator can perform better than several existing methods in terms of the entropy loss and Frobenius loss. An application to a glioblastoma cancer data set reveals some interesting gene networks across multiple cancer subtypes.

  5. Potentials and prospects of precision agriculture in pakistan - a review

    International Nuclear Information System (INIS)

    Mahmood, H.S.; Ahmad, T.; Saeed, M.A.; Iqbal, M.

    2013-01-01

    Precision agriculture is to fine-tune the agricultural production system by emergence and convergence of several information-based technologies for enhancing profit and reducing environmental risks. These technologies have demonstrated to provide benefits to farmers as well as reduced environmental stresses in the developed world. Present paper provides an overview of precision agriculture and examines the potentials, prospects, implications, issues and relevance of precision agricultural applications in Pakistani agricultural system. There is a scope of many precision technologies to be implemented in the country. In this perspective, farmers and government authorities should look forward to adopt new and sustainable technologies to increase the efficiency of available resources and reduce the input costs. Before this, the effectiveness of precision technologies needs to be realised in Pakistan through field experiments and land management practices. (author)

  6. Modeling and Positioning of a PZT Precision Drive System

    Directory of Open Access Journals (Sweden)

    Che Liu

    2017-11-01

    Full Text Available The fact that piezoelectric ceramic transducer (PZT precision drive systems in 3D printing are faced with nonlinear problems with respect to positioning, such as hysteresis and creep, has had an extremely negative impact on the precision of laser focusing systems. To eliminate the impact of PZT nonlinearity during precision drive movement, mathematical modeling and theoretical analyses of each module comprising the system were carried out in this study, a micro-displacement measurement circuit based on Position Sensitive Detector (PSD is constructed, followed by the establishment of system closed-loop control and creep control models. An XL-80 laser interferometer (Renishaw, Wotton-under-Edge, UK was used to measure the performance of the precision drive system, showing that system modeling and control algorithms were correct, with the requirements for precision positioning of the drive system satisfied.

  7. Application of precise training to surgical endoscopic nurses training

    Directory of Open Access Journals (Sweden)

    Zhao Feng

    2017-01-01

    Full Text Available Minimally invasive surgery is an inevitable trend of the development of surgery, the scope of endoscopy surgery application has been covering the whole departments of surgery, which also put forward higher requirements on the nursing coordination during surgery, training high-quality endoscopy nurses is a focus of the researchers. In the paper, the precise training mode was applied to the professional training process of endoscopy nurses, the systematic training of endoscopy nurse was conducted from the following three aspects, including the precision of teaching, the precision of operative cooperation, and the precision of assessment, which had gained good effects. The research indicated that the precise training mode can contribute to upgrading various capacities of endoscopy nurses in the operating room, and improving the teaching quality and effect of specialized training, suggesting a good application effect.

  8. Clinical evaluation of the FreeStyle Precision Pro system.

    Science.gov (United States)

    Brazg, Ronald; Hughes, Kristen; Martin, Pamela; Coard, Julie; Toffaletti, John; McDonnell, Elizabeth; Taylor, Elizabeth; Farrell, Lausanne; Patel, Mona; Ward, Jeanne; Chen, Ting; Alva, Shridhara; Ng, Ronald

    2013-06-05

    A new version of international standard (ISO 15197) and CLSI Guideline (POCT12) with more stringent accuracy criteria are near publication. We evaluated the glucose test performance of the FreeStyle Precision Pro system, a new blood glucose monitoring system (BGMS) designed to enhance accuracy for point-of-care testing (POCT). Precision, interference and system accuracy with 503 blood samples from capillary, venous and arterial sources were evaluated in a multicenter study. Study results were analyzed and presented in accordance with the specifications and recommendations of the final draft ISO 15197 and the new POCT12. The FreeStyle Precision Pro system demonstrated acceptable precision (CV FreeStyle Precision Pro system met the tighter accuracy requirements, providing a means for enhancing accuracy for point-of-care blood glucose monitoring. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Modeling and Positioning of a PZT Precision Drive System.

    Science.gov (United States)

    Liu, Che; Guo, Yanling

    2017-11-08

    The fact that piezoelectric ceramic transducer (PZT) precision drive systems in 3D printing are faced with nonlinear problems with respect to positioning, such as hysteresis and creep, has had an extremely negative impact on the precision of laser focusing systems. To eliminate the impact of PZT nonlinearity during precision drive movement, mathematical modeling and theoretical analyses of each module comprising the system were carried out in this study, a micro-displacement measurement circuit based on Position Sensitive Detector (PSD) is constructed, followed by the establishment of system closed-loop control and creep control models. An XL-80 laser interferometer (Renishaw, Wotton-under-Edge, UK) was used to measure the performance of the precision drive system, showing that system modeling and control algorithms were correct, with the requirements for precision positioning of the drive system satisfied.

  10. Precision Measurements of Tau Lepton Decays

    Energy Technology Data Exchange (ETDEWEB)

    Nugent, Ian M. [Univ. of Victoria, BC (Canada)

    2008-01-01

    Using data collected with the BABAR detector at the SLAC PEP-II electron-positron storage ring operating at a centre-of-mass energy near 10.58 GeV, the branching fractions B(τ- → π-π-π+ντ) =(8.83±0.01±0.13)%, B(τ- → K-π-π+ντ) =(0.273± 0.002 ± 0.009)%, B(τ- → K-π-K+ντ) =(0.1346 ± 0.0010 ± 0.0036)%, and B(τ- → K-K-K+ντ) =(1.58 ± 0.13 ± 0.12) × 10-5 are measured where the uncertainties are statistical and systematic, respectively. The invariant mass distribution for the τ- → π-π-π+ντ , τ- → K-π-π+ντ , τ- → K-π-K+ντ and τ- → K-K-K+ντ decays are unfolded to correct for detector effects. A measurement of B(τ- → φπ-ντ ) =(3.42±0.55±0.25)×10-5, a measurement of B(τ- → φK-ντ) =(3.39±0.20±0.28)× 10-5 and an upper limit on B(τ- → K-K-K+ντ [ex.φ]) ≤ 2.5 × 10-6@90%CL are determined from a binned maximum likelihood fit of the τ- → K-π-K+ντ and τ- → K-K-K+ντ K+K- invariant mass distributions. The branching ratio B(τ-→K-ντ )/ B(τ-→π-ντ ) is measured to be (6.531±0.056±0.093)×10-2 from which |Vus| is determined to be 0.2255 ± 0.0023. The branching ratio B(τ-→μ-ντ $\\bar{v}$μ)/ B(τ-→e-ντ $\\bar{v}$e) =(9.796 ± 0.016 ± 0.035) × 10-1 is measured enabling a precision test of the Standard Model assumption of

  11. Precision templates for gluing wire holding pieces to chamber frames; Plantillas de precision para la construccion de detectores de muones

    Energy Technology Data Exchange (ETDEWEB)

    Berdugo, J.; Burgos, C; Cerrada, M.

    1995-07-01

    In the present report we describe the procedure which has been used in order to optimize the precision obtained when positioning forward backward muon chamber sensor wire planes of the L3 experiment at CERN. With templates produced at CIEMAT a precision of about 10 microns. In sizes of the order of 3 meters. has been achieved. (Author) 2 refs.

  12. Gene mutation-based and specific therapies in precision medicine.

    Science.gov (United States)

    Wang, Xiangdong

    2016-04-01

    Precision medicine has been initiated and gains more and more attention from preclinical and clinical scientists. A number of key elements or critical parts in precision medicine have been described and emphasized to establish a systems understanding of precision medicine. The principle of precision medicine is to treat patients on the basis of genetic alterations after gene mutations are identified, although questions and challenges still remain before clinical application. Therapeutic strategies of precision medicine should be considered according to gene mutation, after biological and functional mechanisms of mutated gene expression or epigenetics, or the correspondent protein, are clearly validated. It is time to explore and develop a strategy to target and correct mutated genes by direct elimination, restoration, correction or repair of mutated sequences/genes. Nevertheless, there are still numerous challenges to integrating widespread genomic testing into individual cancer therapies and into decision making for one or another treatment. There are wide-ranging and complex issues to be solved before precision medicine becomes clinical reality. Thus, the precision medicine can be considered as an extension and part of clinical and translational medicine, a new alternative of clinical therapies and strategies, and have an important impact on disease cures and patient prognoses. © 2015 The Author. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  13. Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.

    Science.gov (United States)

    Shah, Svati H; Arnett, Donna; Houser, Steven R; Ginsburg, Geoffrey S; MacRae, Calum; Mital, Seema; Loscalzo, Joseph; Hall, Jennifer L

    2016-01-12

    The Precision Medicine Initiative recently announced by President Barack Obama seeks to move the field of precision medicine more rapidly into clinical care. Precision medicine revolves around the concept of integrating individual-level data including genomics, biomarkers, lifestyle and other environmental factors, wearable device physiological data, and information from electronic health records to ultimately provide better clinical care to individual patients. The Precision Medicine Initiative as currently structured will primarily fund efforts in cancer genomics with longer-term goals of advancing precision medicine to all areas of health, and will be supported through creation of a 1 million person cohort study across the United States. This focused effort on precision medicine provides scientists, clinicians, and patients within the cardiovascular community an opportunity to work together boldly to advance clinical care; the community needs to be aware and engaged in the process as it progresses. This article provides a framework for potential involvement of the cardiovascular community in the Precision Medicine Initiative, while highlighting significant challenges for its successful implementation. © 2016 American Heart Association, Inc.

  14. Neuronal oscillations enhance stimulus discrimination by ensuring action potential precision

    DEFF Research Database (Denmark)

    Schaefer, Andreas T; Angelo, Kamilla; Spors, Hartwig

    2006-01-01

    generated membrane potential oscillations dramatically improve action potential (AP) precision by removing the membrane potential variance associated with jitter-accumulating trains of APs. This increased AP precision occurred irrespective of cell type and--at oscillation frequencies ranging from 3 to 65 Hz......Although oscillations in membrane potential are a prominent feature of sensory, motor, and cognitive function, their precise role in signal processing remains elusive. Here we show, using a combination of in vivo, in vitro, and theoretical approaches, that both synaptically and intrinsically......, membrane potential oscillations dramatically enhance the discriminatory capabilities of individual neurons and networks of cells and provide one attractive explanation for their abundance in neurophysiological systems....

  15. High Precision Current Control for the LHC Main Power Converters

    CERN Document Server

    Thiesen, H; Hudson, G; King, Q; Montabonnet, V; Nisbet, D; Page, S

    2010-01-01

    Since restarting at the end of 2009, the LHC has reached a new energy record in March 2010 with the two 3.5 TeV beams. To achieve the performance required for the good functioning of the accelerator, the currents in the main circuits (Main Bends and Main Quadrupoles) must be controlled with a higher precision than ever previously requested for a particle accelerator at CERN: a few parts per million (ppm) of nominal current. This paper describes the different challenges that were overcome to achieve the required precision for the current control of the main circuits. Precision tests performed during the hardware commissioning of the LHC illustrate this paper.

  16. Truss Assembly and Welding by Intelligent Precision Jigging Robots

    Science.gov (United States)

    Komendera, Erik; Dorsey, John T.; Doggett, William R.; Correll, Nikolaus

    2014-01-01

    This paper describes an Intelligent Precision Jigging Robot (IPJR) prototype that enables the precise alignment and welding of titanium space telescope optical benches. The IPJR, equipped with micron accuracy sensors and actuators, worked in tandem with a lower precision remote controlled manipulator. The combined system assembled and welded a 2 m truss from stock titanium components. The calibration of the IPJR, and the difference between the predicted and the truss dimensions as-built, identified additional sources of error that should be addressed in the next generation of IPJRs in 2D and 3D.

  17. Precision Medicine and the Changing Landscape of Research Ethics.

    Science.gov (United States)

    Hammer, Marilyn J

    2016-03-01

    President Barack Obama announced the launch of the National Institutes of Health Precision Medicine Initiative® (PMI) in January 2015. Precision medicine includes the concept of individualized or personalized medicine at a more exact level through advances in science and technology, such as genetics and genomics sequencing. Although many disease processes will be investigated through the precision medicine lens for greater understanding and improved treatment responses, oncology research and translation to practice is leading the initiative's debut, referred to as the near-term focus.

  18. [Precision medicine : a required approach for the general internist].

    Science.gov (United States)

    Waeber, Gérard; Cornuz, Jacques; Gaspoz, Jean-Michel; Guessous, Idris; Mooser, Vincent; Perrier, Arnaud; Simonet, Martine Louis

    2017-01-18

    The general internist cannot be a passive bystander of the anticipated medical revolution induced by precision medicine. This latter aims to improve the predictive and/or clinical course of an individual by integrating all biological, genetic, environmental, phenotypic and psychosocial knowledge of a person. In this article, national and international initiatives in the field of precision medicine are discussed as well as the potential financial, ethical and limitations of personalized medicine. The question is not to know if precision medicine will be part of everyday life but rather to integrate early the general internist in multidisciplinary teams to ensure optimal information and shared-decision process with patients and individuals.

  19. Product Surfaces in Precision Engineering, Micorengineering and Nanotechnology

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo; Kunzmann, H.; Peggs, G. N.

    2005-01-01

    This paper is and excerpt from a recently published CIRP Key-Note paper on surfaces in Precision Engineering, Micorengineering and Nanotechnology [1]. It is focussed on the relevance of surface metrology at the micrometric and nanometric length scales. The applied measurement technologies...... are strongly dependent from the functional requirements on those surfaces. Examples of surfaces obtained with precision engineering, microengineering and nanotechnology are mentioned, encompassing surfaces in computers, MEMS, biomedical systems, ligth and X-ray optics, as well as in chemical systems. Surface...... in surface metrology at micro and nanoscale are strongly required for future progress of Precision Engineering, Microengineering, and Nanotechnology; and their fundamental importance can not be overestimated....

  20. Workshop on Precision Measurements of $\\alpha_s$

    Energy Technology Data Exchange (ETDEWEB)

    Bethke, Siegfried; /Munich, Max Planck Inst.; Hoang, Andre H.; /Vienna U.; Kluth, Stefan; /Munich, Max Planck Inst.; Schieck, Jochen; /Munich U.; Stewart, Iain W.; Aoki, S.; Beneke, M.; Bethke, S.; Blumlein, J.; Brambilla, N.; Brodsky, S.; /MIT, LNS

    2011-10-01

    These are the proceedings of the Workshop on Precision Measurements of {alpha}{sub s} held at the Max-Planck-Institute for Physics, Munich, February 9-11, 2011. The workshop explored in depth the determination of {alpha}{sub s}(m{sub Z}) in the {ovr MS} scheme from the key categories where high precision measurements are currently being made, including DIS and global PDF fits, {tau}-decays, electro-weak precision observables and Z-decays, event-shapes, and lattice QCD. These proceedings contain a short summary contribution from the speakers, as well as the lists of authors, conveners, participants, and talks.